Guide to the Human Genome
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Search of human proteins with 201023341

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|201023341 FIP1 like 1 isoform 3 [Homo sapiens]
         (520 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|201023341 FIP1 like 1 isoform 3 [Homo sapiens]                    1077   0.0  
gi|201023339 FIP1 like 1 isoform 2 [Homo sapiens]                    1038   0.0  
gi|40254978 FIP1 like 1 isoform 1 [Homo sapiens]                     1036   0.0  
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                93   5e-19
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        92   1e-18
gi|155030236 ribonuclease III, nuclear isoform 2 [Homo sapiens]        87   5e-17
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    84   2e-16
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]            84   3e-16
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ...    83   7e-16
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]            82   1e-15
gi|155030234 ribonuclease III, nuclear isoform 1 [Homo sapiens]        78   2e-14
gi|197333879 genetic suppressor element 1 isoform 2 [Homo sapiens]     77   4e-14
gi|44955926 genetic suppressor element 1 isoform 1 [Homo sapiens]      77   4e-14
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]         77   5e-14
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti...    76   8e-14
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...    75   1e-13
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...    75   1e-13
gi|169167715 PREDICTED: hypothetical protein [Homo sapiens]            72   1e-12
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            71   2e-12
gi|71044479 death inducer-obliterator 1 isoform c [Homo sapiens]       71   2e-12
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap...    71   3e-12
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            70   4e-12
gi|7662018 PHD finger protein 3 [Homo sapiens]                         70   4e-12
gi|146134388 YLP motif containing 1 [Homo sapiens]                     68   2e-11
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]          67   5e-11
gi|52426743 cisplatin resistance-associated overexpressed protei...    67   5e-11
gi|19923485 cisplatin resistance-associated overexpressed protei...    67   5e-11
gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo sapi...    66   7e-11
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap...    66   9e-11
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             66   9e-11

>gi|201023341 FIP1 like 1 isoform 3 [Homo sapiens]
          Length = 520

 Score = 1077 bits (2785), Expect = 0.0
 Identities = 520/520 (100%), Positives = 520/520 (100%)

Query: 1   MSAGEVERLVSELSGGTGGDEEEEWLYGDENEVERPEEENASANPPSGIEDETAENGVPK 60
           MSAGEVERLVSELSGGTGGDEEEEWLYGDENEVERPEEENASANPPSGIEDETAENGVPK
Sbjct: 1   MSAGEVERLVSELSGGTGGDEEEEWLYGDENEVERPEEENASANPPSGIEDETAENGVPK 60

Query: 61  PKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTTGTK 120
           PKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTTGTK
Sbjct: 61  PKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTTGTK 120

Query: 121 VKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRI 180
           VKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRI
Sbjct: 121 VKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRI 180

Query: 181 RMGLEVIPVTSTTNKITVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRRLPGAI 240
           RMGLEVIPVTSTTNKITVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRRLPGAI
Sbjct: 181 RMGLEVIPVTSTTNKITVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRRLPGAI 240

Query: 241 DVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPF 300
           DVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPF
Sbjct: 241 DVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPF 300

Query: 301 LPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHL 360
           LPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHL
Sbjct: 301 LPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHL 360

Query: 361 PGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPT 420
           PGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPT
Sbjct: 361 PGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPT 420

Query: 421 PSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHES 480
           PSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHES
Sbjct: 421 PSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHES 480

Query: 481 EEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE 520
           EEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE
Sbjct: 481 EEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE 520


>gi|201023339 FIP1 like 1 isoform 2 [Homo sapiens]
          Length = 588

 Score = 1038 bits (2684), Expect = 0.0
 Identities = 520/588 (88%), Positives = 520/588 (88%), Gaps = 68/588 (11%)

Query: 1   MSAGEVERLVSELSGGTGGDEEEEWLYGDENEVERPEEENASANPPSGIEDETAENGVPK 60
           MSAGEVERLVSELSGGTGGDEEEEWLYGDENEVERPEEENASANPPSGIEDETAENGVPK
Sbjct: 1   MSAGEVERLVSELSGGTGGDEEEEWLYGDENEVERPEEENASANPPSGIEDETAENGVPK 60

Query: 61  PKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTTGTK 120
           PKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTTGTK
Sbjct: 61  PKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTTGTK 120

Query: 121 VKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRI 180
           VKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRI
Sbjct: 121 VKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRI 180

Query: 181 RMGLEVIPVTSTTNKIT-----------------------VQQGRTGNSEKETALPSTKA 217
           RMGLEVIPVTSTTNKIT                       VQQGRTGNSEKETALPSTKA
Sbjct: 181 RMGLEVIPVTSTTNKITAEDCTMEVTPGAEIQDGRFNLFKVQQGRTGNSEKETALPSTKA 240

Query: 218 EFTSPPSLFKTGLPPSR------------------------------------RLPGAID 241
           EFTSPPSLFKTGLPPSR                                    RLPGAID
Sbjct: 241 EFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLRRLPGAID 300

Query: 242 VIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL 301
           VIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL
Sbjct: 301 VIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL 360

Query: 302 PPPPTVSTAPPLIPPPG---------FPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPY 352
           PPPPTVSTAPPLIPPPG         FPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPY
Sbjct: 361 PPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPY 420

Query: 353 GNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERE 412
           GNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERE
Sbjct: 421 GNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERE 480

Query: 413 RERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRS 472
           RERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRS
Sbjct: 481 RERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRS 540

Query: 473 NSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE 520
           NSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE
Sbjct: 541 NSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE 588


>gi|40254978 FIP1 like 1 isoform 1 [Homo sapiens]
          Length = 594

 Score = 1036 bits (2678), Expect = 0.0
 Identities = 520/594 (87%), Positives = 520/594 (87%), Gaps = 74/594 (12%)

Query: 1   MSAGEVERLVSELSGGTGGDEEEEWLYG---------------DENEVERPEEENASANP 45
           MSAGEVERLVSELSGGTGGDEEEEWLYG               DENEVERPEEENASANP
Sbjct: 1   MSAGEVERLVSELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDENEVERPEEENASANP 60

Query: 46  PSGIEDETAENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNL 105
           PSGIEDETAENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNL
Sbjct: 61  PSGIEDETAENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNL 120

Query: 106 NIKTGGRVYGTTGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGF 165
           NIKTGGRVYGTTGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGF
Sbjct: 121 NIKTGGRVYGTTGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGF 180

Query: 166 NEDTWKAYCEKQKRIRMGLEVIPVTSTTNKIT-----------------------VQQGR 202
           NEDTWKAYCEKQKRIRMGLEVIPVTSTTNKIT                       VQQGR
Sbjct: 181 NEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTMEVTPGAEIQDGRFNLFKVQQGR 240

Query: 203 TGNSEKETALPSTKAEFTSPPSLFKTGLPPSR---------------------------- 234
           TGNSEKETALPSTKAEFTSPPSLFKTGLPPSR                            
Sbjct: 241 TGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYG 300

Query: 235 --------RLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFF 286
                   RLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFF
Sbjct: 301 RAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFF 360

Query: 287 PPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRS 346
           PPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRS
Sbjct: 361 PPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRS 420

Query: 347 ARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERE 406
           ARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERE
Sbjct: 421 ARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERE 480

Query: 407 RTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETR 466
           RTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETR
Sbjct: 481 RTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETR 540

Query: 467 HKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE 520
           HKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE
Sbjct: 541 HKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE 594


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 52/119 (43%), Positives = 69/119 (57%), Gaps = 9/119 (7%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREY-AERGY 441
           RE++RDR+RDR +ERDRDRDRER+R R+RER  D        N D  R R +    ER  
Sbjct: 343 RERERDRDRDRTKERDRDRDRERDRDRDRERSSDR-------NKDRSRSREKSRDRERER 395

Query: 442 ERHRASREKEERHRER-RHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKE 499
           ER R    + ER RER R RE+E  R +    + +R  E +E D++ R K ++  R KE
Sbjct: 396 EREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKE 454



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 52/124 (41%), Positives = 72/124 (58%), Gaps = 25/124 (20%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           RE++R+RER+R+RER+R+R+RERER RERERER+          D++R R  E  E  YE
Sbjct: 393 RERERERERERERERERERERERERERERERERE---------KDKKRDR-EEDEEDAYE 442

Query: 443 R---HRASREKEERHRER----RHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSK 495
           R    R  REKE  ++ER      RE+++TR            E+E  +  RR   K++K
Sbjct: 443 RRKLERKLREKEAAYQERLKNWEIRERKKTREYEK--------EAEREEERRREMAKEAK 494

Query: 496 RSKE 499
           R KE
Sbjct: 495 RLKE 498



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 51/146 (34%), Positives = 76/146 (52%), Gaps = 20/146 (13%)

Query: 382 RREKDRDRERDRDRERDRDRD-RERERTRERERERDHSPTPSVFNSDEERYRYREYAERG 440
           R+E +++R R+R+RER+R+R+ RERER RERERER+          ++ER R R   ER 
Sbjct: 302 RQEIEKER-RERERERERERERRERERERERERERE---------KEKERERER---ERD 348

Query: 441 YERHRASREKEERHRER---RHREKEETRHKS---SRSNSRRRHESEEGDSHRRHKHKKS 494
            +R R      +R RER   R RE+   R+K    SR  SR R    E +  R  + ++ 
Sbjct: 349 RDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERE 408

Query: 495 KRSKEGKEAGSEPAPEQESTEATPAE 520
           +  +  +E   E   E+E  +    E
Sbjct: 409 REREREREREREREREREKDKKRDRE 434



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 43/142 (30%), Positives = 73/142 (51%), Gaps = 6/142 (4%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
           + SK  D + + E+++ ++    +E +++R   RER RERERER+          + ER 
Sbjct: 280 EISKFRDTHKKLEEEKGKKEKERQEIEKER---RERERERERERERRERERERERERERE 336

Query: 432 RYREYAERGYERHRASREKEERHRER-RHREKEETRHKSSRSNSRRRHESEEGDSHRRHK 490
           + +E  ER  ER R     +ER R+R R R+++  R +SS  N  R    E+     R +
Sbjct: 337 KEKE-RERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER 395

Query: 491 HKKSKRSKEGKEAGSEPAPEQE 512
            ++ +R +E +E   E   E+E
Sbjct: 396 ERERERERE-RERERERERERE 416



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 37/158 (23%), Positives = 66/158 (41%), Gaps = 22/158 (13%)

Query: 375 KQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYR 434
           K W+      ++R + R+ ++E +R+ +R RE  +E +R ++          D + YR  
Sbjct: 462 KNWEI-----RERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGS 516

Query: 435 EYAERGYERHRASREKEERHRERRHREKEETRHK--------------SSRSNSRRRHES 480
              +R  +R +   E +ER R+R   E EE R +                   + RR + 
Sbjct: 517 ALQKRLRDREK-EMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQP 575

Query: 481 EEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATP 518
           +        + ++ K+ KE K    EP  E+E  E  P
Sbjct: 576 QIKQEPESEEEEEEKQEKEEKR--EEPMEEEEEPEQKP 611



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 29/122 (23%), Positives = 50/122 (40%), Gaps = 6/122 (4%)

Query: 398 DRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRER 457
           + + D+    +RE  + RD           +E+ R     ER        RE+E R RER
Sbjct: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERER 327

Query: 458 -----RHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQE 512
                R REKE+ R +  R   R R  ++E D  R  +  + +  +   +   + +  +E
Sbjct: 328 EREREREREKEKERER-ERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSRE 386

Query: 513 ST 514
            +
Sbjct: 387 KS 388



 Score = 37.0 bits (84), Expect = 0.044
 Identities = 18/38 (47%), Positives = 20/38 (52%), Gaps = 2/38 (5%)

Query: 297 PPPFLPPPPTVSTAPPLIPPPGFP--PPPGAPPPSLIP 332
           PP    PP  +   PP IPPP FP  PPP  P   +IP
Sbjct: 4   PPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIP 41



 Score = 35.8 bits (81), Expect = 0.097
 Identities = 21/52 (40%), Positives = 25/52 (48%), Gaps = 3/52 (5%)

Query: 283 PPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTI 334
           PP   P  PP  +PPP F   PP V    P+IP P     P   P  L+PT+
Sbjct: 10  PPMGIPALPPG-IPPPQFPGFPPPVPPGTPMIPVPMSIMAPA--PTVLVPTV 58



 Score = 29.6 bits (65), Expect = 7.0
 Identities = 14/36 (38%), Positives = 18/36 (50%), Gaps = 1/36 (2%)

Query: 282 PPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPP 317
           PPP FP G PP   P  P +P P ++    P +  P
Sbjct: 22  PPPQFP-GFPPPVPPGTPMIPVPMSIMAPAPTVLVP 56


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 56/147 (38%), Positives = 80/147 (54%), Gaps = 15/147 (10%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
           D  ++ +    RE+ R+RER+R++ERDR+RDR+R+  RERERER+        + ++ER 
Sbjct: 698 DREREKERELERERAREREREREKERDRERDRDRDHDRERERERER-------DREKERE 750

Query: 432 RYREYAERGYERHRASREKEERHRER-RHREKEETRHK------SSRSNSRRRHESEEGD 484
           R RE  ER  ER R    + ER RER R R+KE  R +        R + R + E    D
Sbjct: 751 REREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIRED 810

Query: 485 SHRRHKHKKSKRSKEGKEAGSEPAPEQ 511
            + R  H + K  K  +  GS P+P Q
Sbjct: 811 RNPRDGHDERKSKKRYRNEGS-PSPRQ 836



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 49/141 (34%), Positives = 78/141 (55%), Gaps = 12/141 (8%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
           + +++ D    R+++R+RER+R+R+R+R+++RE ER R RERER+          D ER 
Sbjct: 674 ERARERDRERERDRERERERERERDREREKERELERERAREREREREK-----ERDRERD 728

Query: 432 RYREY-AERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHK 490
           R R++  ER  ER R   ++ ER RE R RE+E  R +       R  E E   +  R K
Sbjct: 729 RDRDHDRERERERERDREKEREREREERERERERERER------ERERERERERARERDK 782

Query: 491 HKKSKRSKEGKEAGSEPAPEQ 511
            ++ +R  E K+ G +   E+
Sbjct: 783 ERERQRDWEDKDKGRDDRREK 803



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 51/131 (38%), Positives = 69/131 (52%), Gaps = 17/131 (12%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           R  +R RERDR+RERDR+R+RERER R+RERE++          + ER R RE      E
Sbjct: 671 RRDERARERDRERERDRERERERERERDREREKER---------ELERERARER-----E 716

Query: 443 RHRASREKEERHRERRH-REKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGK 501
           R R      ER R+R H RE+E  R +  R   R R   E      R + ++ +R +E +
Sbjct: 717 REREKERDRERDRDRDHDRERERERER-DREKEREREREERERERERERERERERERE-R 774

Query: 502 EAGSEPAPEQE 512
           E   E   E+E
Sbjct: 775 ERARERDKERE 785



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 48/154 (31%), Positives = 76/154 (49%), Gaps = 18/154 (11%)

Query: 378 DYYARREKDRDRERDRDRERDR-DRDRERERTRERERERDHSPTPSVFNSDEERYRYREY 436
           D+   RE++R+R+R+++RER+R +R+RERER RERERER+          D+ER R R++
Sbjct: 732 DHDRERERERERDREKEREREREERERERERERERERERERE-RERARERDKERERQRDW 790

Query: 437 AERGYERHRASREKEERHRERRHREKEETRHKSSR-----------SNSRRRHESEEGDS 485
            ++   R     ++EE   +R  R+  + R    R           S  RRR  S + D+
Sbjct: 791 EDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDA 850

Query: 486 HRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPA 519
           +     K  K         S+    QES   +P+
Sbjct: 851 YNSGDDKNEKH-----RLLSQVVRPQESRSLSPS 879



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 54/132 (40%), Positives = 68/132 (51%), Gaps = 21/132 (15%)

Query: 382 RREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGY 441
           R E+  DR  DR  ER R+RDRERER RERERER+            ER R RE  ER  
Sbjct: 660 REERRVDRVDDRRDERARERDRERERDRERERERER-----------ERDRERE-KEREL 707

Query: 442 ERHRASREKEERHRERRHREKEETRHKS-SRSNSRRRHESEEGDSHRRHKHKKSKRSKEG 500
           ER RA RE+E      R REKE  R +   R + R R    E D  +  + ++ +R +E 
Sbjct: 708 ERERA-RERE------REREKERDRERDRDRDHDRERERERERDREKEREREREERERE- 759

Query: 501 KEAGSEPAPEQE 512
           +E   E   E+E
Sbjct: 760 RERERERERERE 771



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 43/132 (32%), Positives = 69/132 (52%), Gaps = 8/132 (6%)

Query: 375  KQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYR 434
            ++WD  A  +KD  R RDRDR R+R+R+RER++ R+ +RER+   + SV   D +R R R
Sbjct: 1321 REWDRDA--DKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSV-ERDRDRDRDR 1377

Query: 435  EYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKS 494
             +     E    S ++ E   E  H    E+  + S +  + R + + G      +  KS
Sbjct: 1378 TFESSQIE----SVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKS 1433

Query: 495  KRSKEGKEAGSE 506
            +R+ E  EAG +
Sbjct: 1434 ERT-ESLEAGDD 1444



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 41/147 (27%), Positives = 66/147 (44%), Gaps = 15/147 (10%)

Query: 380 YARREKDRDRERDRDRERDRD---RDRERERTRERERERDHSPTPSVFNSDEERYRYREY 436
           + RR  +RDR  +R+R++      R + R    ER+  R+      V +  +ER R R+ 
Sbjct: 622 FERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERD- 680

Query: 437 AERGYERHRASREKEERHRER-----------RHREKEETRHKSSRSNSRRRHESEEGDS 485
            ER  +R R    + ER RER           R RE+E  + +    +  R H+ E    
Sbjct: 681 RERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERE 740

Query: 486 HRRHKHKKSKRSKEGKEAGSEPAPEQE 512
             R + K+ +R +E +E   E   E+E
Sbjct: 741 RERDREKEREREREERERERERERERE 767



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 42/149 (28%), Positives = 63/149 (42%), Gaps = 50/149 (33%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERE------------------------------ 412
           RE++R+RER+R+RER R+RD+ERER R+ E                              
Sbjct: 762 RERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERK 821

Query: 413 ------------------RERDHSPTPSVFNS-DEERYRYREYAERGYERHRASREKEER 453
                             R R+HSP    +NS D++  ++R  ++    +   S      
Sbjct: 822 SKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHL 881

Query: 454 HRERRHREKEETRHKSSRSNSRRRHESEE 482
             +R+ R KEE R K  R  S RR+E +E
Sbjct: 882 TEDRQGRWKEEDR-KPERKESSRRYEEQE 909



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 40/149 (26%), Positives = 62/149 (41%), Gaps = 7/149 (4%)

Query: 367  WPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNS 426
            WP   D  +  +    RE+D+ R+ DR+RER      ER+R R+R+R  + S   SV   
Sbjct: 1331 WPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESV--- 1387

Query: 427  DEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSH 486
              +R   +   E   +    SR+     +ER  ++    +     + S R    E GD  
Sbjct: 1388 --KRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDE 1445

Query: 487  RRHKHKKSKRSKEGKEAGSEPAPEQESTE 515
             +     S  S  G+  G EP  + E  E
Sbjct: 1446 SKLDDAHSLGSGAGE--GYEPISDDELDE 1472



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 42/158 (26%), Positives = 69/158 (43%), Gaps = 12/158 (7%)

Query: 345 RSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRE 404
           RSA  +P  +++ P    S P   S +    + D+  R  +  DR  +R  +    RDRE
Sbjct: 369 RSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDH-ERTSQSHDRRHERREDTRGKRDRE 427

Query: 405 RERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEE 464
           ++   ERE E+D S +    +  E R         G +R R +R+  +R   R  R+  +
Sbjct: 428 KDSREEREYEQDQSSSRDHRDDREPR--------DGRDR-RDARDTRDRRELRDSRDMRD 478

Query: 465 TRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKE 502
           +R    R  SR   ES +    R  +     R +EG++
Sbjct: 479 SR--EMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRD 514



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 45/184 (24%), Positives = 74/184 (40%), Gaps = 26/184 (14%)

Query: 358 PHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRD-RERDRDRDRERERTRERERE-- 414
           P  P   P  P  +   K++     + KDR  E+ RD ++R RD +R+RE+ R++ R   
Sbjct: 261 PRTPSPPPPIPEDIALGKKYKE-KYKVKDRIEEKTRDGKDRGRDFERQREK-RDKPRSTS 318

Query: 415 ---RDHSPTPSVFNSDEERY-----------RYREYAERGYER------HRASREKEERH 454
              + HSP  S  +S   +            R +      Y+R       R++       
Sbjct: 319 PAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHS 378

Query: 455 RERRHREKEETRHKSS-RSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQES 513
                R++   RH+S  R   R  HE       RRH+ ++  R K  +E  S    E E 
Sbjct: 379 LSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQ 438

Query: 514 TEAT 517
            +++
Sbjct: 439 DQSS 442



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 42/140 (30%), Positives = 60/140 (42%), Gaps = 17/140 (12%)

Query: 378  DYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSD--EERYRYRE 435
            D   R E  R    DR   R       R  + E +R+  HS + S  + D  +ER RY  
Sbjct: 1252 DQLKRGEPSRSTSSDRQDSRSHS---SRRSSPESDRQV-HSRSGSFDSRDRLQERDRYEH 1307

Query: 436  YAERGYERHRASREKE---------ERHRER-RHREKEETRHKSSRSNSRRRHESEEGDS 485
              ER  ER R +R++E          R+R+R R RE+E  R +  R +  R  E    DS
Sbjct: 1308 DRERERER-RDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDS 1366

Query: 486  HRRHKHKKSKRSKEGKEAGS 505
              R + +   R+ E  +  S
Sbjct: 1367 VERDRDRDRDRTFESSQIES 1386



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 38/121 (31%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 387 RDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRA 446
           RDR   RD    RD    R+ +R+ +  RD  P  S    D   YR RE    G + HR 
Sbjct: 465 RDRRELRDSRDMRDSREMRDYSRDTKESRD--PRDSRSTRDAHDYRDRE----GRDTHR- 517

Query: 447 SREKEERH-RERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSK-RSKEGKEAG 504
              KE+ +  E R   +   R +SSR+  R    +E     R  +  +S+ R  E  E G
Sbjct: 518 ---KEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKG 574

Query: 505 S 505
           S
Sbjct: 575 S 575



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 27/141 (19%), Positives = 56/141 (39%), Gaps = 15/141 (10%)

Query: 390  ERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASRE 449
            E  + R ++ DR  ER+ +  R  E++     S  +   E+    E +    +      +
Sbjct: 883  EDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQ 942

Query: 450  KEERHRERRHREKEETRHKSSRSNSRRRHE-------------SEEGD--SHRRHKHKKS 494
             E+R    R  ++ + + K  +   +++ E             SE+G   S ++ + KKS
Sbjct: 943  SEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKS 1002

Query: 495  KRSKEGKEAGSEPAPEQESTE 515
               K  K  G     ++E+ +
Sbjct: 1003 IEKKRKKSKGDSDISDEEAAQ 1023



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 39/145 (26%), Positives = 57/145 (39%), Gaps = 19/145 (13%)

Query: 387 RDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRA 446
           ++  R R RE++ D    +ERT E E E     T +  +SD     Y    E   E  R 
Sbjct: 114 KESSRGRHREKE-DIKITKERTPESEEENVEWET-NRDDSDNGDINYDYVHELSLEMKRQ 171

Query: 447 SREKEERHRERRHREKEE------------TRHKSSRSNSRRRHESEEGDSHRRHKHKKS 494
             ++E    E+ + EK E             R K S S S R+         R+   K S
Sbjct: 172 KIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSK---SPKRKSSPKSS 228

Query: 495 KRSKEGKE--AGSEPAPEQESTEAT 517
             SK+ ++  A S P  +Q+    T
Sbjct: 229 SASKKDRKTSAVSSPLLDQQRNSKT 253



 Score = 30.0 bits (66), Expect = 5.3
 Identities = 47/205 (22%), Positives = 77/205 (37%), Gaps = 37/205 (18%)

Query: 303  PPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPG 362
            P  T S    L+PPP  PP   A   ++  T+ +  ++   S S  A      A P    
Sbjct: 1090 PGSTPSPLSSLLPPP--PPVATATATTVPATLAATTAAAATSFSTSAITISTSATP---- 1143

Query: 363  SAPSWPSLVDTSKQWDYYARREKDRDRERDR------------DRERDRDRDRERERTRE 410
                      T+   + +A  +  R   R R            D +  +  D++R  +  
Sbjct: 1144 ----------TNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLG 1193

Query: 411  RERE-RDHSPTPSVFNSDEERYRYREYAERGYER--HRASREKEERHR-----ERRHREK 462
              R  R H+       S++  +R  +  + G +R  H  SR++E+        ER+ R  
Sbjct: 1194 SNRSNRSHTSGRLRSPSNDSAHRSGD-DQSGRKRVLHSGSRDREKTKSLEITGERKSRID 1252

Query: 463  EETRHKSSRSNSRRRHESEEGDSHR 487
            +  R + SRS S  R +S    S R
Sbjct: 1253 QLKRGEPSRSTSSDRQDSRSHSSRR 1277



 Score = 29.3 bits (64), Expect = 9.1
 Identities = 32/115 (27%), Positives = 44/115 (38%), Gaps = 14/115 (12%)

Query: 374 SKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRY 433
           S++   Y+R  K+    RD    RD    R+RE  R+  R+ D  P  S           
Sbjct: 479 SREMRDYSRDTKESRDPRDSRSTRDAHDYRDRE-GRDTHRKEDTYPEES----------- 526

Query: 434 REYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRR 488
           R Y  R + R  +SR  E R+  R     E    +  RS  R     E+G    R
Sbjct: 527 RSYG-RNHLREESSR-TEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSR 579


>gi|155030236 ribonuclease III, nuclear isoform 2 [Homo sapiens]
          Length = 1337

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 79/253 (31%), Positives = 99/253 (39%), Gaps = 23/253 (9%)

Query: 283 PPFFPPGAPPTHLPPPPFLP-PPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSG 341
           PP FPP  PP   P  P +P  PP   T P ++PPP  P PP  PPP +   +   +  G
Sbjct: 114 PPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPP--PPPVMPQQVNYQYPPG 171

Query: 342 YDSRSARAFP------YGNVAFPHLP----GSAPSWPSLVDTSKQWDYYARREKDRDRER 391
           Y   S   FP      + N     LP     S+P +  L           RR  +R +  
Sbjct: 172 Y---SHHNFPPPSFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHY 228

Query: 392 DRDRERDRDRDR-ERERT---RERERERDHSPTPSVFNSDEERYRYREYAERGYERHRAS 447
           D  R RD    R ER R+   RER R  D     S + SD +R R      R YER R  
Sbjct: 229 DDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYDRGR-TPSRHRSYERSRER 287

Query: 448 REKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHR--RHKHKKSKRSKEGKEAGS 505
             +  RHR+ R     E  +K     S  R  S E    R    K + S     GK+   
Sbjct: 288 ERERHRHRDNRRSPSLERSYKKEYKRSGSRSPSREKKRARWEEEKDRWSDNQSSGKDKNY 347

Query: 506 EPAPEQESTEATP 518
               E+E  E  P
Sbjct: 348 TSIKEKEPEETMP 360


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 44/151 (29%), Positives = 73/151 (48%), Gaps = 3/151 (1%)

Query: 373 TSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYR 432
           T ++ D    R +++DR R RDR R+R RDRE+ER R+ +RERD           E    
Sbjct: 71  TERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERE 130

Query: 433 YREYAERGYERHRASREKEERHRE---RRHREKEETRHKSSRSNSRRRHESEEGDSHRRH 489
                ERG +R    + + ER R+    R R+ +  R + +  N ++  E E+    RR 
Sbjct: 131 TEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRE 190

Query: 490 KHKKSKRSKEGKEAGSEPAPEQESTEATPAE 520
           + ++ ++  + ++  SE   E+E    T  E
Sbjct: 191 RERQREKENKTEDRHSERGRERERERETETE 221



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 50/141 (35%), Positives = 75/141 (53%), Gaps = 17/141 (12%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHS-PTPSVFNSDEERYRYREY---AE 438
           RE +R RER R+RER+R+R+R+RER RERERER+    T      + ER R R+     E
Sbjct: 295 RETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRE 354

Query: 439 RGYERHRASREKEERHRER-RHREKEETRHKSSRSNSRRRHESEE------------GDS 485
           R  +  R  R + ER RER R R+++  R +  R   R R   +E             ++
Sbjct: 355 RNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRET 414

Query: 486 HRRHKHKKSKRSKEGKEAGSE 506
            ++ + +K + S+ G+E G E
Sbjct: 415 EKQREREKDRESERGRERGRE 435



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 52/155 (33%), Positives = 83/155 (53%), Gaps = 19/155 (12%)

Query: 375 KQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRY- 433
           +Q +    RE++R RER+R+RER+R+R RE ER RE+ERER       +   D ER R  
Sbjct: 303 RQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEM---DRERNRQT 359

Query: 434 ----REYAERGYERHR-----ASREKEERHRER---RHREKEETRHK---SSRSNSRRRH 478
               R  AER  ER R     ++RE+EER R+R   R +E+E    K     R   ++R 
Sbjct: 360 GREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQRE 419

Query: 479 ESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQES 513
             ++ +S R  +  + +  ++G+E   E   ++++
Sbjct: 420 REKDRESERGRERGREREKQKGRERDRERQTDRQA 454



 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 49/139 (35%), Positives = 79/139 (56%), Gaps = 7/139 (5%)

Query: 382 RREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGY 441
           +RE++R+RER+R+R+R+ +RDRE+ER R+R+R+ +     +     E R +     ER  
Sbjct: 316 KRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERER 375

Query: 442 ERHRAS-REKEERHRER-RHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKE 499
           ER R S RE+EER R+R R R+KE  R      + +R  E +      R K ++S+R +E
Sbjct: 376 ERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQ----REREKDRESERGRE 431

Query: 500 -GKEAGSEPAPEQESTEAT 517
            G+E   +   E++    T
Sbjct: 432 RGREREKQKGRERDRERQT 450



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 57/163 (34%), Positives = 82/163 (50%), Gaps = 27/163 (16%)

Query: 375 KQWDYYARREKDRDRERDRDRERDRDRDRERERT----------------RERERERDHS 418
           +Q D    RE+  DRERDR RE++R+R +ERER                 RERER+RD +
Sbjct: 97  RQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRD-A 155

Query: 419 PTPSVFNSDEERYRYRE-YAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRR 477
                  +D ER R  E   ++  ER +  +E+ ER R+R    K E RH S R   R R
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRH-SERGRERER 214

Query: 478 HESEEGDSHR-------RHKHKKSKRSKEGKEAGSEPAPEQES 513
               E ++ R       R + +K++R +E K+A  E A E+E+
Sbjct: 215 ERETETETERKRQTDRERDRQRKTERERE-KQAERERASERET 256



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 48/137 (35%), Positives = 73/137 (53%), Gaps = 7/137 (5%)

Query: 382 RREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGY 441
           RR+K+R+R+ DR R+R  +RDRE ER RER+RER+        N   ER R R   ER  
Sbjct: 274 RRQKERERQTDRKRQRRTERDRETERKRERQRERERERER---NRKRERERER---ERER 327

Query: 442 ERHRASREKEERHRER-RHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEG 500
           ER R +    E+ RER R R+ E  R ++ ++    R ++E      R + ++S R +E 
Sbjct: 328 ERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREE 387

Query: 501 KEAGSEPAPEQESTEAT 517
           +E   +   ++E    T
Sbjct: 388 RERDRDRDRQKERERQT 404



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 50/151 (33%), Positives = 77/151 (50%), Gaps = 12/151 (7%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHS---PTPSVFNSDE 428
           +  KQ +     E++ +R+++R+RERDRDRDR+R R +ERER+ D      T     ++ 
Sbjct: 241 EREKQAERERASERETERDKERERERDRDRDRDR-RQKERERQTDRKRQRRTERDRETER 299

Query: 429 ERYRYREYAERGYERHRASREKEERHRER-------RHREKEETRHKSSRSNSRRRHESE 481
           +R R RE  ER  ER+R    + ER RER       R REKE  R +  ++   R    +
Sbjct: 300 KRERQRE-RERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQ 358

Query: 482 EGDSHRRHKHKKSKRSKEGKEAGSEPAPEQE 512
            G   RR   ++ +R +E     +    E+E
Sbjct: 359 TGREGRRQAERERERERERDRQSAREREERE 389



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 38/133 (28%), Positives = 67/133 (50%), Gaps = 5/133 (3%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
           D  K+ +    RE+ R  ER+R +ER+R+++R+  R RER+RE+++           ER 
Sbjct: 154 DAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE 213

Query: 432 RYREYAERGYERHRASREKEERHRERRHREKEETRHKSS-----RSNSRRRHESEEGDSH 486
           R RE       + +  RE++ + +  R REK+  R ++S     R   R R    + D  
Sbjct: 214 RERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRD 273

Query: 487 RRHKHKKSKRSKE 499
           RR K ++ +  ++
Sbjct: 274 RRQKERERQTDRK 286



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 45/141 (31%), Positives = 70/141 (49%), Gaps = 3/141 (2%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
           +  +Q D    R++  +RER++  ER+R  +RE ER +ERERERD          + ER 
Sbjct: 223 ERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQ 282

Query: 432 RYREYAERGYERHRASREKEERHRER-RHREKEETRHKS-SRSNSRRRHESEEGDSHRRH 489
             R+  +R  ER R +  K ER RER R RE+   R +   R   R R    E D  +  
Sbjct: 283 TDRK-RQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKER 341

Query: 490 KHKKSKRSKEGKEAGSEPAPE 510
           + K+ ++++  +E   +   E
Sbjct: 342 ERKRKRQTEMDRERNRQTGRE 362



 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 45/136 (33%), Positives = 68/136 (50%), Gaps = 6/136 (4%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           REK  +RER  +RE +RD++RERER R+R+R+R          +D +R R R   +R  E
Sbjct: 242 REKQAERERASERETERDKERERERDRDRDRDRRQKERER--QTDRKRQR-RTERDRETE 298

Query: 443 RHRASREKEERHRER---RHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKE 499
           R R  + + ER RER   R RE+E  R +  +  + R  E E     +R      +R+++
Sbjct: 299 RKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQ 358

Query: 500 GKEAGSEPAPEQESTE 515
               G   A  +   E
Sbjct: 359 TGREGRRQAERERERE 374



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 48/165 (29%), Positives = 80/165 (48%), Gaps = 24/165 (14%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRE-------------RERERD-- 416
           +  +Q D   +R+ +R+R+++R+RE++R   RERER RE             RERER+  
Sbjct: 158 ERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERE 217

Query: 417 -HSPTPSVFNSDEERYRYRE---YAERGYERHRASREKEERHRER-----RHREKEETRH 467
             + T     +D ER R R+     E+  ER RAS  + ER +ER     R R+++  + 
Sbjct: 218 TETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQK 277

Query: 468 KSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQE 512
           +  R   R+R    E D     K ++ +  +  +E   +   E+E
Sbjct: 278 ERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERE 322



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 41/143 (28%), Positives = 77/143 (53%), Gaps = 5/143 (3%)

Query: 374 SKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDE---ER 430
           +K  D ++ R ++R+RER+ + E +R R  +RER R+R+ ER+         + E   ER
Sbjct: 199 NKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETER 258

Query: 431 YRYREYAERGYERHRASREKE-ERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRH 489
            + RE  ER  +R R  R+KE ER  +R+ + + E   ++ R   R+R    E + +R+ 
Sbjct: 259 DKERE-RERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKR 317

Query: 490 KHKKSKRSKEGKEAGSEPAPEQE 512
           + ++ +  +  ++  +E   E+E
Sbjct: 318 ERERERERERERQRETERDREKE 340



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 38/127 (29%), Positives = 62/127 (48%), Gaps = 9/127 (7%)

Query: 382 RREKDRDRERDRDRERDRDRDRER--ERTRERERERDHSPTPSVFNSDEERYRYREYAER 439
           +RE++R R+ +++RER  DR+R+R  ER R++ERER+        N  E R R R+  + 
Sbjct: 146 QRERERQRDAEKERERQTDRERQRQTERNRQKEREREK-------NRQERRERERQREKE 198

Query: 440 GYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKE 499
                R S    ER RER    + E + ++ R   R+R    E +     +    + ++ 
Sbjct: 199 NKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETER 258

Query: 500 GKEAGSE 506
            KE   E
Sbjct: 259 DKERERE 265



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 41/127 (32%), Positives = 63/127 (49%), Gaps = 2/127 (1%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
           D  K+ +   +R+ + DRER+R   R+  R  ERER RERER+R  +        D +R 
Sbjct: 336 DREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRD 395

Query: 432 RYREYAERGYERHRASREKEERHRER-RHREKEETRHKSSRSNSRRRHESEEGDSHRRHK 490
           R +E  ER  E+ R  + + E+ RER + RE E  R +      ++  E +      R  
Sbjct: 396 RQKE-RERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQA 454

Query: 491 HKKSKRS 497
            ++ KRS
Sbjct: 455 GRQRKRS 461



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 44/133 (33%), Positives = 63/133 (47%), Gaps = 16/133 (12%)

Query: 383 REKDRDRERDR----DRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAE 438
           REK+R+R+R R    DRER+R   RE  R  ERERER+          + +R   RE  E
Sbjct: 337 REKERERKRKRQTEMDRERNRQTGREGRRQAERERERER---------ERDRQSAREREE 387

Query: 439 RGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSK 498
           R  +R R  +++ ER  E+    + ET  +  R   R   ESE G    R + K+  R +
Sbjct: 388 RERDRDRDRQKERERQTEKDRDGQRETEKQREREKDR---ESERGRERGREREKQKGRER 444

Query: 499 EGKEAGSEPAPEQ 511
           + +      A  Q
Sbjct: 445 DRERQTDRQAGRQ 457



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 46/154 (29%), Positives = 74/154 (48%), Gaps = 18/154 (11%)

Query: 372 DTSKQWDYYARREKDRDRERDRDR---------ERDRDRDRERERTRERERERDHSPTPS 422
           + ++Q     RR+ +R+RER+R+R         ER+RDRDR+R++ RER+ E+D      
Sbjct: 354 ERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRE 413

Query: 423 VFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSN-------SR 475
                 ER + RE +ERG ER R   +++ R R+R  +   +   +  RS          
Sbjct: 414 T-EKQREREKDRE-SERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRT 471

Query: 476 RRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAP 509
            R    + D +R  +  + K S E  +A S   P
Sbjct: 472 ARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFP 505



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 49/163 (30%), Positives = 73/163 (44%), Gaps = 19/163 (11%)

Query: 360 LPGSAPSWPSL-VDTSKQWDYYARREKDRDRERDRD-----RERDRDRDRERERTRERER 413
           +P +A    +L V+ +   D+  RR   ++  R R      ++ D D DRER R +ERER
Sbjct: 6   VPATADQLGTLWVEVTIPLDFSRRRPGSQESPRRRGLGQAHKDADGD-DRERNRQKERER 64

Query: 414 ERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRER-RHREKEETRHKSSRS 472
            R+   T     +D +R R RE      +RHR    K +RHRER R REKE  R      
Sbjct: 65  RREKRQTER--ETDRKRERRRE-----KDRHR----KRDRHRERQRDREKERERQTDRER 113

Query: 473 NSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTE 515
           + +R  E        R   ++ +R ++ +  G      Q   E
Sbjct: 114 DRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAE 156


>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 202

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 52/152 (34%), Positives = 82/152 (53%), Gaps = 10/152 (6%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHS---PTPSVFNSDE 428
           D  ++ D    REK+R+R+++RDR+R R+R+ ERE  R+RER+R       T    + D 
Sbjct: 41  DRHRERDRQTDREKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDR 100

Query: 429 ERYRYREYAERGYERHR-ASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHR 487
           +R R RE  +R  ER+R   RE++++    R RE+E  R +  R   R+R    E D  R
Sbjct: 101 DRERKRE-TDRNRERNRKGGRERDKQTERERDRERERQRQRE-RERQRQRERKRETDRER 158

Query: 488 RH----KHKKSKRSKEGKEAGSEPAPEQESTE 515
           +     + +K +R KE K+   E   E++  E
Sbjct: 159 QRWAEREERKKERKKERKKERKEKKKEEKRRE 190



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 48/138 (34%), Positives = 72/138 (52%), Gaps = 5/138 (3%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDR--DRDRERERTRERERERDHSPTPSVFNSDEE 429
           D  +Q +    RE +R RER R RER R  DR+R+++R RER+RE D +   +      E
Sbjct: 63  DRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERN-RKGGRE 121

Query: 430 RYRYREYAERGYERHRASREKEERHRER-RHREKEETRHKSSRSNSRRRHESEEGDSHRR 488
           R +  E  ER  ER R  + + ER R+R R RE +  R + +    R++   +E    R+
Sbjct: 122 RDKQTE-RERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERK 180

Query: 489 HKHKKSKRSKEGKEAGSE 506
            K K+ KR ++ K    E
Sbjct: 181 EKKKEEKRREDKKRKWGE 198



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 54/172 (31%), Positives = 80/172 (46%), Gaps = 29/172 (16%)

Query: 372 DTSKQWDYYARRE-----KDRDRERDRDRERDRDRDRERERTRERERERDHS---PTPSV 423
           +T ++ D    RE     ++R R+RDR RERDR  DRE+ER R++ER+R       T   
Sbjct: 16  ETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQRQRERETERE 75

Query: 424 FNSDEERYRYREY-----AERGYERHRASREKEERHRER---------------RHREKE 463
                ER R RE       ER  +R R  + + +R+RER               R RE+E
Sbjct: 76  TERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTERERDRERE 135

Query: 464 ETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTE 515
             R +  R   R+R    E D  R+   ++ +R KE K+   +   E++  E
Sbjct: 136 RQRQR-ERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKEKKKEE 186



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 43/134 (32%), Positives = 65/134 (48%), Gaps = 8/134 (5%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           R+++R RE DR +E +R+RDR+RER  + ERE  H         D  R R R+  +R  E
Sbjct: 3   RQRERKRETDRGKETERERDRQRERENQTERENRHR------QRDRHRERDRQ-TDREKE 55

Query: 443 RHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHR-RHKHKKSKRSKEGK 501
           R R      +R RER    + E + +  R   R+R    E D  R R + +++ R++E  
Sbjct: 56  RERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERN 115

Query: 502 EAGSEPAPEQESTE 515
             G     +Q   E
Sbjct: 116 RKGGRERDKQTERE 129



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 45/136 (33%), Positives = 72/136 (52%), Gaps = 13/136 (9%)

Query: 382 RREKDRDRE--RDRDRERDRDRDRERE---RTRERERERDHSPTPSVFNSDEERYRYREY 436
           +RE DR +E  R+RDR+R+R+   ERE   R R+R RERD        + ++ER R +E 
Sbjct: 8   KRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQT-----DREKERERQKE- 61

Query: 437 AERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKR 496
            +R  +R R +  + ER RER+ + + + +    R   R R    E D   R +++K  R
Sbjct: 62  RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETD-RNRERNRKGGR 120

Query: 497 SKEGKEAGSEPAPEQE 512
            ++ K+   E   E+E
Sbjct: 121 ERD-KQTERERDRERE 135



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 36/107 (33%), Positives = 51/107 (47%), Gaps = 20/107 (18%)

Query: 396 ERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHR 455
           ER R+R RE +R +E ERERD               R RE  E   ER    R++ +RHR
Sbjct: 2   ERQRERKRETDRGKETERERD---------------RQRE-RENQTERENRHRQR-DRHR 44

Query: 456 ER---RHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKE 499
           ER     REKE  R K      +R  E+E     +R + ++ +R ++
Sbjct: 45  ERDRQTDREKERERQKERDRQRQRERETERETERQRERQRQRERKRQ 91



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 17/76 (22%), Positives = 34/76 (44%), Gaps = 1/76 (1%)

Query: 442 ERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGK 501
           ER R  + + +R +E   RE++  R + +++    RH   +    R  +  + K  +  K
Sbjct: 2   ERQRERKRETDRGKETE-RERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQK 60

Query: 502 EAGSEPAPEQESTEAT 517
           E   +   E+E+   T
Sbjct: 61  ERDRQRQRERETERET 76


>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
           containing B [Homo sapiens]
          Length = 546

 Score = 82.8 bits (203), Expect = 7e-16
 Identities = 48/148 (32%), Positives = 81/148 (54%), Gaps = 11/148 (7%)

Query: 382 RREKDRDRERD--RDRERDRDRDRER--ERTRERERERDHSPTPSVFNSDEERYRYREYA 437
           RR++DR+RE++  R R RDRD D+ER  ER +ERER R+ S         EE+    +  
Sbjct: 349 RRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKD 408

Query: 438 ERGYERHRASREKEERH-----RERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHK 492
           +R +   +   +KE++H     RER+HR +  +R+   RS SR + +S +       K K
Sbjct: 409 DRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSK--HKNESKEK 466

Query: 493 KSKRSKEGKEAGSEPAPEQESTEATPAE 520
            +KRS+ G +  ++   + +  E +P++
Sbjct: 467 SNKRSRSGSQGRTDSVEKSKKREHSPSK 494



 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 50/143 (34%), Positives = 71/143 (49%), Gaps = 15/143 (10%)

Query: 371 VDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEER 430
           ++  K+     R  K+R++ER R R  DR  +R R R+RER R R  S        D +R
Sbjct: 295 LEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDR 354

Query: 431 YRYREY-----------AERGYERHRASREKEERHRERRHR-EKEETRHKSSRSNSRRRH 478
            R +E             ERG ER +      ER +E+R R E EE +HK  + +  RRH
Sbjct: 355 EREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDD--RRH 412

Query: 479 ESEEGDSHRRHKHKKSKRSKEGK 501
             ++ DS +  KH +S RS+E K
Sbjct: 413 RDDKRDSKKEKKHSRS-RSRERK 434



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 46/144 (31%), Positives = 66/144 (45%), Gaps = 29/144 (20%)

Query: 378 DYYARREKDRDRERDRDRER-----------------DRDRDRERERTRERERERDHSPT 420
           DY   R  +R++ER+R RER                 D+D  R R+  R+ ++E+ HS +
Sbjct: 369 DYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRS 428

Query: 421 PSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHES 480
            S       R R R   +R   R   S+EK  +H+     E +E  +K SRS S+ R +S
Sbjct: 429 RSRERKHRSRSRSRNAGKRSRSR---SKEKSSKHK----NESKEKSNKRSRSGSQGRTDS 481

Query: 481 EEGDSHRRH-----KHKKSKRSKE 499
            E    R H     K +K  RSKE
Sbjct: 482 VEKSKKREHSPSKEKSRKRSRSKE 505



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 34/129 (26%), Positives = 60/129 (46%), Gaps = 12/129 (9%)

Query: 382 RREKDRDRERDR------DRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYRE 435
           RR + R   R+       DRE +R+++R+R     +ERE++   + S+    E R     
Sbjct: 274 RRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERR----- 328

Query: 436 YAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSK 495
              R  ERHR+     +R  +RR R++E  +         R ++ E G+   + + +  +
Sbjct: 329 -RSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRE 387

Query: 496 RSKEGKEAG 504
           RSKE +  G
Sbjct: 388 RSKEQRSRG 396



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 49/159 (30%), Positives = 66/159 (41%), Gaps = 24/159 (15%)

Query: 385 KDRDRERDRD-RERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYRE-------- 435
           K R R+  +D +E   + DR  ER R R   R  SP  S   S   R  +RE        
Sbjct: 234 KTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRS-RSRSHHREGHGSSSFD 292

Query: 436 -YAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHR------- 487
              ER  ER R  RE +ER +ERR     +   +  RS SR RH S      R       
Sbjct: 293 RELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDR 352

Query: 488 -RHKHKKSKRSKE-----GKEAGSEPAPEQESTEATPAE 520
            R + K+++R +       KE G+E   E+E +     E
Sbjct: 353 DREREKENERGRRRDRDYDKERGNEREKERERSRERSKE 391



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 32/118 (27%), Positives = 54/118 (45%), Gaps = 7/118 (5%)

Query: 385 KDRDRERDRDRERDRDRDRERERT-RERERERDHSPTPSVFNSDEERYRYREYAERGYER 443
           + RD +RD  +E+   R R RER  R R R R+        + ++      E  E+  +R
Sbjct: 411 RHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKR 470

Query: 444 HRAS----REKEERHRERRHREKEETRHKSSRSNSR--RRHESEEGDSHRRHKHKKSK 495
            R+      +  E+ ++R H   +E   K SRS  R  +R  S+  D   +H  ++S+
Sbjct: 471 SRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQ 528



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 27/122 (22%), Positives = 56/122 (45%), Gaps = 2/122 (1%)

Query: 382 RREKDRDRERDRDRERDRDRDRERERTRER-ERERDHSPTPSVFNSDEERYRYREYAERG 440
           +R+  ++++  R R R+R + R R R+R   +R R  S   S  + +E + +  + +  G
Sbjct: 416 KRDSKKEKKHSRSRSRER-KHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSG 474

Query: 441 YERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEG 500
            +    S EK ++      +EK   R +S   + +R H   +  S +  + +     +E 
Sbjct: 475 SQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQES 534

Query: 501 KE 502
           +E
Sbjct: 535 QE 536



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 33/141 (23%), Positives = 64/141 (45%), Gaps = 30/141 (21%)

Query: 382 RREKDRDRERDRDRERDRDRDRERERTRERERE--------------RDHSPTPSVFNSD 427
           + ++D+D  R RD +RD  ++++  R+R RER+              R  S   S  + +
Sbjct: 402 KHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKN 461

Query: 428 EERYRYREYAERGYE------------RHRASREKEE---RHRERRH-REKEETRHKSSR 471
           E + +  + +  G +             H  S+EK     R +ER H R+  +++ +S +
Sbjct: 462 ESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDK 521

Query: 472 SNSRRRHESEEGDSHRRHKHK 492
            + RR    E+    ++HK+K
Sbjct: 522 HDRRRSQSIEQESQEKQHKNK 542



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 21/78 (26%), Positives = 43/78 (55%), Gaps = 15/78 (19%)

Query: 388 DRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRAS 447
           ++ + R+    +++ R+R R++ER  +RDHS +     SD+            ++R R S
Sbjct: 483 EKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKD--QSDK------------HDRRR-S 527

Query: 448 REKEERHRERRHREKEET 465
           +  E+  +E++H+ K+ET
Sbjct: 528 QSIEQESQEKQHKNKDET 545



 Score = 33.9 bits (76), Expect = 0.37
 Identities = 14/48 (29%), Positives = 27/48 (56%)

Query: 371 VDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHS 418
           V+ SK+ ++   +EK R R R ++R   RD    ++++ + +R R  S
Sbjct: 482 VEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQS 529


>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 290

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 53/156 (33%), Positives = 83/156 (53%), Gaps = 13/156 (8%)

Query: 373 TSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERD-HSPTPSVFNSDEERY 431
           T  + D    ++K R+RERDR RER+RDRDRE+ER R+ E++RD    T +    D ER 
Sbjct: 119 TEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDRERE 178

Query: 432 RYRE-YAERGYERHRASREKEERHRER-RHREKE-------ETRHKSSRSNSRRR---HE 479
           + +E   ER  +R R + ++ ER  +R R R+++       ET  +  R   RRR    +
Sbjct: 179 KQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRD 238

Query: 480 SEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTE 515
            + G    R + +K +R KE K+   +   E++  E
Sbjct: 239 RDRGKERDRERDRKEERKKERKKERKKERKEKKKEE 274



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 48/139 (34%), Positives = 71/139 (51%), Gaps = 16/139 (11%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
           D   Q +    RE+DR+RE+ ++RE +RDRDR+R+  +ERER+           +D ER 
Sbjct: 160 DRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQ-----------TDRERD 208

Query: 432 RYRE-YAERGYERHRASREKEERHRER---RHREKEETRHKSSRSNSRRRHESEEGDSHR 487
           R R+   ER  E  R    + +R RER   R R KE  R +  R   R++   +E    R
Sbjct: 209 RQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRER-DRKEERKKERKKERKKER 267

Query: 488 RHKHKKSKRSKEGKEAGSE 506
           + K K+ KR ++ K    E
Sbjct: 268 KEKKKEEKRREDKKRKWGE 286



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 43/134 (32%), Positives = 76/134 (56%), Gaps = 10/134 (7%)

Query: 382 RREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYRE-YAERG 440
           R+EK+ +R RDR+++ + +RDRERE+ + RERERD          + ER R RE   ER 
Sbjct: 104 RKEKETNRNRDREKQTEIERDREREKQKGRERERDR-------GRERERDRDREKERERQ 156

Query: 441 YERHRASREKEERHRER-RHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKE 499
            E+ R  + + E  RER R REK++ R ++ R   R+R   +E +     +  + ++++ 
Sbjct: 157 TEKDRDGQRETETERERDREREKQKER-ETERDRDRQRDTEKERERQTDRERDRQRKTQT 215

Query: 500 GKEAGSEPAPEQES 513
            ++  ++   E+E+
Sbjct: 216 ERQRETDREGERET 229



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 40/131 (30%), Positives = 66/131 (50%), Gaps = 11/131 (8%)

Query: 375 KQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYR 434
           K+ +    R++++  E +RDRER++ + RERER R RERERD          D E+ R R
Sbjct: 105 KEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDR---------DREKERER 155

Query: 435 EYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHR-RHKHKK 493
           +  E+  +  R +  + ER RER  +++ ET     R     +    + D  R R +  +
Sbjct: 156 Q-TEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQ 214

Query: 494 SKRSKEGKEAG 504
           ++R +E    G
Sbjct: 215 TERQRETDREG 225



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 45/150 (30%), Positives = 75/150 (50%), Gaps = 14/150 (9%)

Query: 382 RREKDR-----DRERDRDRERDRDRDR-ERERTRERERERDHSPTPSVFNSDEERYRYRE 435
           +RE+DR     ++ERDRDR+RDR+R R E+E  R R+RE+    T    + + E+ + RE
Sbjct: 78  QRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQ---TEIERDREREKQKGRE 134

Query: 436 -YAERGYERHRASREKEERHR----ERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHK 490
              +RG ER R    ++ER R    +R  + + ET  +  R   +++    E D  R+  
Sbjct: 135 RERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRD 194

Query: 491 HKKSKRSKEGKEAGSEPAPEQESTEATPAE 520
            +K +  +  +E   +   + E    T  E
Sbjct: 195 TEKERERQTDRERDRQRKTQTERQRETDRE 224



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 43/121 (35%), Positives = 63/121 (52%), Gaps = 13/121 (10%)

Query: 383 REKDRDRERDR-DRERDRDRDRERERTR---ERERERDHSPTPSVFNSDEERYRYREYAE 438
           R+++RDR R++ ++ERDRDR R+RER R   E  R RD      +     ER R RE  +
Sbjct: 77  RQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEI-----ERDRERE-KQ 130

Query: 439 RGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSK 498
           +G ER R    + ER R+   REKE  R      + +R  E+E      R K K+ +  +
Sbjct: 131 KGRERERDRGRERERDRD---REKERERQTEKDRDGQRETETERERDREREKQKERETER 187

Query: 499 E 499
           +
Sbjct: 188 D 188



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 35/124 (28%), Positives = 56/124 (45%), Gaps = 7/124 (5%)

Query: 397 RDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRE 456
           +D D D +R+R R+R RE+    T    + D +R R R   E+   R+R  REK+     
Sbjct: 70  KDADGD-DRQRERDRVREK----TEKERDRDRKRDRERRRKEKETNRNR-DREKQTEIER 123

Query: 457 RRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEA 516
            R REK++ R +  R   R R    + +  R  + +K +  +   E   E   E+E  + 
Sbjct: 124 DREREKQKGRER-ERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKE 182

Query: 517 TPAE 520
              E
Sbjct: 183 RETE 186


>gi|155030234 ribonuclease III, nuclear isoform 1 [Homo sapiens]
          Length = 1374

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 68/211 (32%), Positives = 86/211 (40%), Gaps = 21/211 (9%)

Query: 283 PPFFPPGAPPTHLPPPPFLP-PPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSG 341
           PP FPP  PP   P  P +P  PP   T P ++PPP  P PP  PPP +   +   +  G
Sbjct: 114 PPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPP--PPPVMPQQVNYQYPPG 171

Query: 342 YDSRSARAFP------YGNVAFPHLP----GSAPSWPSLVDTSKQWDYYARREKDRDRER 391
           Y   S   FP      + N     LP     S+P +  L           RR  +R +  
Sbjct: 172 Y---SHHNFPPPSFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHY 228

Query: 392 DRDRERDRDRDR-ERERT---RERERERDHSPTPSVFNSDEERYRYREYAERGYERHRAS 447
           D  R RD    R ER R+   RER R  D     S + SD +R R      R YER R  
Sbjct: 229 DDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYDRGR-TPSRHRSYERSRER 287

Query: 448 REKEERHRERRHREKEETRHKSSRSNSRRRH 478
             +  RHR+ R     E  +K     S R +
Sbjct: 288 ERERHRHRDNRRSPSLERSYKKEYKRSGRSY 318


>gi|197333879 genetic suppressor element 1 isoform 2 [Homo sapiens]
          Length = 1113

 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 76/240 (31%), Positives = 114/240 (47%), Gaps = 45/240 (18%)

Query: 292 PTHLPPPPFLPPPPTVSTAPPL--IPPPGFP-PPPGAPPPSLIPTIESGHSSGYDSRSAR 348
           P++L P PF  P   +  +  L  +  P +P P PG+ PP L P+    H SG   R   
Sbjct: 148 PSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPP-LHPSAMHLHLSGV--RYPP 204

Query: 349 AFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERT 408
              + ++A  H    +     L     Q D   RRE++R+RER+R+RE DR+R++ERER 
Sbjct: 205 ELSHSSLAALH----SERMSGLSAERLQMDEELRREREREREREREREADREREKERERE 260

Query: 409 RERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKE-ERHRERRHREKEETRH 467
           RE+ERE+           ++ER R +E            RE+E ER RE+R REKE    
Sbjct: 261 REKEREQ-----------EKEREREKE------------RERELERQREQRAREKELLAA 297

Query: 468 KS--------SRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSE-PAPEQESTEATP 518
           K+        +  +  R H +EE    +  +     R+++ K+AG + P P Q      P
Sbjct: 298 KALEPSFLPVAELHGLRGHATEE--RGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVP 355


>gi|44955926 genetic suppressor element 1 isoform 1 [Homo sapiens]
          Length = 1217

 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 76/240 (31%), Positives = 114/240 (47%), Gaps = 45/240 (18%)

Query: 292 PTHLPPPPFLPPPPTVSTAPPL--IPPPGFP-PPPGAPPPSLIPTIESGHSSGYDSRSAR 348
           P++L P PF  P   +  +  L  +  P +P P PG+ PP L P+    H SG   R   
Sbjct: 252 PSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPP-LHPSAMHLHLSGV--RYPP 308

Query: 349 AFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERT 408
              + ++A  H    +     L     Q D   RRE++R+RER+R+RE DR+R++ERER 
Sbjct: 309 ELSHSSLAALH----SERMSGLSAERLQMDEELRREREREREREREREADREREKERERE 364

Query: 409 RERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKE-ERHRERRHREKEETRH 467
           RE+ERE+           ++ER R +E            RE+E ER RE+R REKE    
Sbjct: 365 REKEREQ-----------EKEREREKE------------RERELERQREQRAREKELLAA 401

Query: 468 KS--------SRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSE-PAPEQESTEATP 518
           K+        +  +  R H +EE    +  +     R+++ K+AG + P P Q      P
Sbjct: 402 KALEPSFLPVAELHGLRGHATEE--RGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVP 459


>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
          Length = 953

 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 51/128 (39%), Positives = 71/128 (55%), Gaps = 16/128 (12%)

Query: 380 YARREKDRDRE-RDRDRERDRDRDRERERT-RERERERDHSPTPSVFNSDEERYRYREYA 437
           Y  RE++R+RE R R+RER+R+RDRERER  RERERER+H         D+ER R +E  
Sbjct: 401 YRERERERERENRQRERERERERDRERERRQREREREREH-------ERDKERQRRKE-- 451

Query: 438 ERGYERHRASREKEERHRERRHREKEETRHKSS---RSNSRRRHESEEGDSHRRHKHKKS 494
              +ER RA R++++R    R REKE  + K     RS      ++E           + 
Sbjct: 452 --EWERERAKRDEKDRQHRDRDREKEREKEKGKPKPRSPQPPSRQAEPPKKEAATTGPQV 509

Query: 495 KRSKEGKE 502
           KR+ E K+
Sbjct: 510 KRADEWKD 517



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 79/280 (28%), Positives = 111/280 (39%), Gaps = 68/280 (24%)

Query: 280 SKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIP------- 332
           +K  PF P GAPP  L P P +P  P        I PP   PPP  P  S          
Sbjct: 255 TKADPFPPNGAPP--LGPHPLMPANPWGGPVVDEILPP---PPPEPPTESAWERGLRHAK 309

Query: 333 ------TIESGHSSGYDSR--------SARAFPYGNVAFPHLPGSAPSWPSLVDTSKQ-- 376
                 TI       ++ +          R F   N  F       P    + DT  +  
Sbjct: 310 EVLKKATIRKEQEPDFEEKRFTVTIGEDEREFDKENEVFRDWNSRIPR--DVRDTVLEPY 367

Query: 377 ----WDYYARR-------EKDRDRERDRD-----RERDRDRDRE-RERTRERERERDHSP 419
               +DY   R       E  R +  + +     RER+R+R+RE R+R RERERERD   
Sbjct: 368 ADPYYDYEIERFWRGGQYENFRVQYTETEPYHNYRERERERERENRQRERERERERD--- 424

Query: 420 TPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHE 479
                       R RE  +R  ER R    + ER +ER+ R++E  R ++ R    R+H 
Sbjct: 425 ------------RERERRQRERERER----EHERDKERQRRKEEWERERAKRDEKDRQHR 468

Query: 480 SEEGDSHR-RHKHKKSKRSKEGKEAGSEPAPEQESTEATP 518
             + +  R + K K   RS +     +EP P++E+    P
Sbjct: 469 DRDREKEREKEKGKPKPRSPQPPSRQAEP-PKKEAATTGP 507



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 41/141 (29%), Positives = 73/141 (51%), Gaps = 8/141 (5%)

Query: 382 RREKDRDRERDRDRER---DRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAE 438
           +RE++R+RERDR+RER   +R+R+RE ER +ER+R ++          DE+  ++R+  +
Sbjct: 414 QRERERERERDRERERRQREREREREHERDKERQRRKEEWERERA-KRDEKDRQHRD-RD 471

Query: 439 RGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSK 498
           R  ER +   + + R  +   R+ E  + +++ +  + +   E  D  RR    KS + K
Sbjct: 472 REKEREKEKGKPKPRSPQPPSRQAEPPKKEAATTGPQVKRADEWKDPWRR---SKSPKKK 528

Query: 499 EGKEAGSEPAPEQESTEATPA 519
            G       A  +  T A+ A
Sbjct: 529 LGVSVSPSRARRRRKTSASSA 549



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 39/153 (25%), Positives = 69/153 (45%), Gaps = 25/153 (16%)

Query: 382 RREKDRDRERDRDRERDRDRDR-ERERTRERERERDH-------------------SPTP 421
           +RE++R+RE +RD+ER R ++  ERER +  E++R H                   SP P
Sbjct: 431 QREREREREHERDKERQRRKEEWERERAKRDEKDRQHRDRDREKEREKEKGKPKPRSPQP 490

Query: 422 SVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESE 481
               ++  +   +E A  G +  RA   K+   R +  ++K       S S +RRR ++ 
Sbjct: 491 PSRQAEPPK---KEAATTGPQVKRADEWKDPWRRSKSPKKKLGV--SVSPSRARRRRKTS 545

Query: 482 EGDSHRRHKHKKSKRSKEGKEAGSEPAPEQEST 514
              +   +  + S RS     +GS  +  + S+
Sbjct: 546 ASSASASNSSRSSSRSSSYSGSGSSRSRSRSSS 578



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 59/259 (22%), Positives = 99/259 (38%), Gaps = 26/259 (10%)

Query: 283 PPFFPPGAPPTHLPPPPFLPPPPTVSTAP-PLIPPPGFP------PPPGAPPPSLIPTIE 335
           PP    G      P PP  PP  T +TAP P    PG P        P   PP       
Sbjct: 627 PPPGKAGEKSVKKPAPPPAPPQATKTTAPVPEPTKPGDPREARRKERPARTPPRRRTLSG 686

Query: 336 SGHSSG--YDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDR 393
           SG  SG  Y   S+R+    +V+      SA S  S   +    D YA           R
Sbjct: 687 SGSGSGSSYSGSSSRSRSL-SVSSVSSVSSATSSSSSAHSVDSEDMYADLASPVSSASSR 745

Query: 394 -----DRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASR 448
                   +++ + ++ +  +E +R+RD S  P       +     + +++     +A  
Sbjct: 746 SPAPAQTRKEKGKSKKEDGVKEEKRKRDSSTQPP---KSAKPPAGGKSSQQPSTPQQAPP 802

Query: 449 EKEERHRERRHRE-KEETRHKSSRSNSRRRHESEEGDSH-----RRHKHKKSKRSKEGKE 502
            + ++     H+E K    +K++   SR+R+E  + D       +R      + S++ K 
Sbjct: 803 GQPQQGTFVAHKEIKLTLLNKAADKGSRKRYEPSDKDRQSPPPAKRPNTSPDRGSRDRKS 862

Query: 503 AG--SEPAPEQESTEATPA 519
            G    P PE++  + + A
Sbjct: 863 GGRLGSPKPERQRGQNSKA 881


>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
           [Homo sapiens]
          Length = 213

 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 51/155 (32%), Positives = 76/155 (49%), Gaps = 21/155 (13%)

Query: 372 DTSKQWDYYARREKDRDRERD----------RDRERDRDRDRERERTRERERERD-HSPT 420
           +  +Q D    RE+DRDRER+          R+RERDRDR RE ER R++ERE D H+ T
Sbjct: 45  ERDRQRDRERNRERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTET 104

Query: 421 PSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHES 480
                 D ER + +   ER  ER R    ++++   R  +   ET  +  R   R R   
Sbjct: 105 ------DRERQKQK---EREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETG 155

Query: 481 EEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTE 515
            E  +  RH+ ++ +R +E +E   E    +  T+
Sbjct: 156 RERKTEDRHRERERERKRE-RERKRETKERERHTD 189



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 49/152 (32%), Positives = 76/152 (50%), Gaps = 12/152 (7%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
           + +++ D    REK  DRE +R RER+RDRDR+RE  RER++ER+   T     +D ER 
Sbjct: 53  ERNRERDRDREREKQTDREGERQRERERDRDRQRETERERDKERE---TDRHTETDRERQ 109

Query: 432 RYREYA-ERGYERHRASREKEERHRER-----RHREKEETRHKSSRSNSRRRHESEEGDS 485
           + +E   ER  +R R  +++  R R+      R RE++  R    R   R R   +    
Sbjct: 110 KQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAER---ERETGRERKTEDRHRE 166

Query: 486 HRRHKHKKSKRSKEGKEAGSEPAPEQESTEAT 517
             R + ++ +R +E KE       E+E    T
Sbjct: 167 RERERKRERERKRETKERERHTDMERERQRET 198



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 47/145 (32%), Positives = 71/145 (48%), Gaps = 13/145 (8%)

Query: 382 RREKDRDRER-------DRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYR 434
           RRE DR+R+R       DR  ERDR RDRER R R+R+RER+   T        ER R R
Sbjct: 24  RRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDRERE-KQTDREGERQRERERDR 82

Query: 435 EYAERGYERHRASREKEERH----RERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHK 490
           +  +R  ER R    + +RH    RER+ +++ E      R   +++    E  + R   
Sbjct: 83  D-RQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETD 141

Query: 491 HKKSKRSKEGKEAGSEPAPEQESTE 515
            ++ ++++  +E G E   E    E
Sbjct: 142 RERERQAERERETGRERKTEDRHRE 166



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 48/156 (30%), Positives = 73/156 (46%), Gaps = 32/156 (20%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERE------------------------R 407
           +  KQ D    R+++R+R+RDR RE +R+RD+ERE                        R
Sbjct: 63  EREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDR 122

Query: 408 TRERERERDHSPTPSVFNSDEERYRYRE-YAERGYERHRASREKEERHRERRHREKEETR 466
            RE+++E           +D E  R RE  AER  E  R  R+ E+RHRE R RE++  R
Sbjct: 123 EREKQKEMGRER-----QTDRETDRERERQAERERETGR-ERKTEDRHRE-RERERKRER 175

Query: 467 HKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKE 502
            +   +  R RH   E +  R    K+ ++ +  +E
Sbjct: 176 ERKRETKERERHTDMERERQRETDRKRDRQRESERE 211



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 38/113 (33%), Positives = 57/113 (50%), Gaps = 4/113 (3%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
           D  +Q       E+ RDRER++ +E  R+R  +RE  RERER+ +           E+R+
Sbjct: 105 DRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRH 164

Query: 432 RYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGD 484
           R RE  ER  ER    R++E + RER    + E + ++ R   R+R    E D
Sbjct: 165 RERE-RERKRER---ERKRETKERERHTDMERERQRETDRKRDRQRESERERD 213



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 43/134 (32%), Positives = 68/134 (50%), Gaps = 17/134 (12%)

Query: 388 DRERDRDRERDRDRDRERE-----RTRERERERDHSPTPSVFNSDEERYRYRE-YAERGY 441
           DR+R+R RE DR+RDR +E     R  ER+R+RD        N + +R R RE   +R  
Sbjct: 18  DRQRERRRETDRERDRAKESKTEDRHSERDRQRDRER-----NRERDRDREREKQTDREG 72

Query: 442 ERHRASREKEERHRE---RRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSK 498
           ER R      +R RE    R +E+E  RH  +    R R + +E +  R    ++ K+ +
Sbjct: 73  ERQRERERDRDRQRETERERDKERETDRHTET---DRERQKQKEREMERVRDREREKQKE 129

Query: 499 EGKEAGSEPAPEQE 512
            G+E  ++   ++E
Sbjct: 130 MGRERQTDRETDRE 143



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 16/64 (25%), Positives = 29/64 (45%), Gaps = 1/64 (1%)

Query: 449 EKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPA 508
           E  +R RERR RE +  R ++  S +  RH   +    R    ++ +  +  K+   E  
Sbjct: 15  ETMDRQRERR-RETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGE 73

Query: 509 PEQE 512
            ++E
Sbjct: 74  RQRE 77


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 49/153 (32%), Positives = 75/153 (49%), Gaps = 27/153 (17%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
           D  ++ D    +EKDR+RER+++ E+DRD+++E+E+ +E+ERE+D S        DE+R 
Sbjct: 418 DKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK-----EIDEKRK 472

Query: 432 RYRE--YAERGYERHRASREKEERHRERRHREKEET-------RHKSSRSNS-------- 474
           + ++     R Y   R SR      R RR R    +       + KSSRS S        
Sbjct: 473 KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD 532

Query: 475 -----RRRHESEEGDSHRRHKHKKSKRSKEGKE 502
                 R H SE  +  R    +KS   ++GKE
Sbjct: 533 KKREKERDHISERRERERSTSMRKSSNDRDGKE 565



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 39/143 (27%), Positives = 77/143 (53%), Gaps = 14/143 (9%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           R K++DRE++R+RE++R++++ER + ++R++ER+          D ER R +E+ E+  +
Sbjct: 389 RVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDK-EKDREREREKEH-EKDRD 446

Query: 443 RHRASREKEERHRER-RHREKEETRHKSSRS-------NSRRRHESEEGDSHRRHKHKKS 494
           + +   + +E+ RE+ R +E +E R K  +S       N+ RR  S   +  RR     S
Sbjct: 447 KEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS 506

Query: 495 KRSKEGK----EAGSEPAPEQES 513
           +  +  K    ++   P+P   +
Sbjct: 507 RSPRTSKTIKRKSSRSPSPRSRN 529



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 46/145 (31%), Positives = 74/145 (51%), Gaps = 18/145 (12%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           + KDRD+ER++DRE+D+++DRERER  E+E E+D          D+E+ R ++ ++   E
Sbjct: 413 KNKDRDKEREKDREKDKEKDRERER--EKEHEKDRDKEKEK-EQDKEKEREKDRSKEIDE 469

Query: 443 R-------------HRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRH 489
           +             + ASR      RERR R +  +  +S R++   + +S    S R  
Sbjct: 470 KRKKDKKSRTPPRSYNASRRSRSSSRERR-RRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 528

Query: 490 KHKKSKRSKEGKEAGSEPAPEQEST 514
             K  KR KE ++  SE    + ST
Sbjct: 529 NKKDKKREKE-RDHISERRERERST 552



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 38/146 (26%), Positives = 74/146 (50%), Gaps = 21/146 (14%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           +EKDR++ER+R++ER+++++R + + R++ERE+D        + +++R R RE      +
Sbjct: 391 KEKDREKEREREKEREKEKERGKNKDRDKEREKDREK-----DKEKDRERERE------K 439

Query: 443 RHRASREKEERHRERRHREKEETR----------HKSSRSNSRRRHESEEGDSHRRHKHK 492
            H   R+KE+   + + +E+E+ R           K SR+  R  + S    S  R + +
Sbjct: 440 EHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRR 499

Query: 493 KSKRSKEGKEAGSEPAPEQESTEATP 518
           +  RS       S+    + S   +P
Sbjct: 500 RRSRSSSRSPRTSKTIKRKSSRSPSP 525



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 36/114 (31%), Positives = 68/114 (59%), Gaps = 11/114 (9%)

Query: 382 RREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGY 441
           +R+  R++ ++++R +++DR++ERER +ERE+E++        N D ++ R ++  E+  
Sbjct: 376 KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGK-----NKDRDKEREKD-REKDK 429

Query: 442 ERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSK 495
           E+ R  RE+E+ H + R +EKE+ + K       R  E +E    +R K KKS+
Sbjct: 430 EKDR-EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE----KRKKDKKSR 478



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 34/136 (25%), Positives = 65/136 (47%), Gaps = 3/136 (2%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           + K R R  +R R R +DR R +   ++R + R+   + S  +S ++R   RE  +    
Sbjct: 330 QSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKER 389

Query: 443 RHRASREKEERHRERRHREKEETRHK---SSRSNSRRRHESEEGDSHRRHKHKKSKRSKE 499
                REKE    + R +EKE  ++K     R   R + + ++ +  R  +H+K +  ++
Sbjct: 390 VKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEK 449

Query: 500 GKEAGSEPAPEQESTE 515
            KE   E   E++ ++
Sbjct: 450 EKEQDKEKEREKDRSK 465



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 43/162 (26%), Positives = 69/162 (42%), Gaps = 30/162 (18%)

Query: 384 EKDRDRERDR--DRERDRDRDRERERTRERERERDHSPTPSVFN-------SDEERYRYR 434
           EKDRD+E+++  D+E++R++DR +E   +R++++     P  +N       S  ER R R
Sbjct: 442 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501

Query: 435 EYAE--------------------RGYERHRASREKEERH-RERRHREKEETRHKSSRSN 473
             +                     R   +    REKE  H  ERR RE+  +  KSS   
Sbjct: 502 SRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDR 561

Query: 474 SRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTE 515
             +    +   S +  +H K   S   KE   + AP  E  +
Sbjct: 562 DGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 31/133 (23%), Positives = 58/133 (43%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           R + +DR R +   + R + RER ++R R   RD          ++ER + ++  +    
Sbjct: 342 RSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERER 401

Query: 443 RHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKE 502
                +EKE    + R +E+E+ R K    +  R  E E      + K K+  + KE ++
Sbjct: 402 EKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK 461

Query: 503 AGSEPAPEQESTE 515
             S+   E+   +
Sbjct: 462 DRSKEIDEKRKKD 474



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 35/121 (28%), Positives = 61/121 (50%), Gaps = 10/121 (8%)

Query: 380 YARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAER 439
           + +R K R+R + R R   RD+   R+ TRE+ +E++      V   D E+ R RE  ER
Sbjct: 355 HKKRSKSRERRKSRSRSHSRDK---RKDTREKIKEKER-----VKEKDREKERERE-KER 405

Query: 440 GYERHRASREKEERHRER-RHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSK 498
             E+ R   +  ++ RE+ R ++KE+ R +       +  + E+     + K ++  RSK
Sbjct: 406 EKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK 465

Query: 499 E 499
           E
Sbjct: 466 E 466


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
           [Homo sapiens]
          Length = 508

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 49/153 (32%), Positives = 75/153 (49%), Gaps = 27/153 (17%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
           D  ++ D    +EKDR+RER+++ E+DRD+++E+E+ +E+ERE+D S        DE+R 
Sbjct: 302 DKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK-----EIDEKRK 356

Query: 432 RYRE--YAERGYERHRASREKEERHRERRHREKEET-------RHKSSRSNS-------- 474
           + ++     R Y   R SR      R RR R    +       + KSSRS S        
Sbjct: 357 KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD 416

Query: 475 -----RRRHESEEGDSHRRHKHKKSKRSKEGKE 502
                 R H SE  +  R    +KS   ++GKE
Sbjct: 417 KKREKERDHISERRERERSTSMRKSSNDRDGKE 449



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 39/143 (27%), Positives = 77/143 (53%), Gaps = 14/143 (9%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           R K++DRE++R+RE++R++++ER + ++R++ER+          D ER R +E+ E+  +
Sbjct: 273 RVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDK-EKDREREREKEH-EKDRD 330

Query: 443 RHRASREKEERHRER-RHREKEETRHKSSRS-------NSRRRHESEEGDSHRRHKHKKS 494
           + +   + +E+ RE+ R +E +E R K  +S       N+ RR  S   +  RR     S
Sbjct: 331 KEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS 390

Query: 495 KRSKEGK----EAGSEPAPEQES 513
           +  +  K    ++   P+P   +
Sbjct: 391 RSPRTSKTIKRKSSRSPSPRSRN 413



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 46/145 (31%), Positives = 74/145 (51%), Gaps = 18/145 (12%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           + KDRD+ER++DRE+D+++DRERER  E+E E+D          D+E+ R ++ ++   E
Sbjct: 297 KNKDRDKEREKDREKDKEKDRERER--EKEHEKDRDKEKEK-EQDKEKEREKDRSKEIDE 353

Query: 443 R-------------HRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRH 489
           +             + ASR      RERR R +  +  +S R++   + +S    S R  
Sbjct: 354 KRKKDKKSRTPPRSYNASRRSRSSSRERR-RRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 412

Query: 490 KHKKSKRSKEGKEAGSEPAPEQEST 514
             K  KR KE ++  SE    + ST
Sbjct: 413 NKKDKKREKE-RDHISERRERERST 436



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 38/146 (26%), Positives = 74/146 (50%), Gaps = 21/146 (14%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           +EKDR++ER+R++ER+++++R + + R++ERE+D        + +++R R RE      +
Sbjct: 275 KEKDREKEREREKEREKEKERGKNKDRDKEREKDREK-----DKEKDRERERE------K 323

Query: 443 RHRASREKEERHRERRHREKEETR----------HKSSRSNSRRRHESEEGDSHRRHKHK 492
            H   R+KE+   + + +E+E+ R           K SR+  R  + S    S  R + +
Sbjct: 324 EHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRR 383

Query: 493 KSKRSKEGKEAGSEPAPEQESTEATP 518
           +  RS       S+    + S   +P
Sbjct: 384 RRSRSSSRSPRTSKTIKRKSSRSPSP 409



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 36/114 (31%), Positives = 68/114 (59%), Gaps = 11/114 (9%)

Query: 382 RREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGY 441
           +R+  R++ ++++R +++DR++ERER +ERE+E++        N D ++ R ++  E+  
Sbjct: 260 KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGK-----NKDRDKEREKD-REKDK 313

Query: 442 ERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSK 495
           E+ R  RE+E+ H + R +EKE+ + K       R  E +E    +R K KKS+
Sbjct: 314 EKDR-EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE----KRKKDKKSR 362



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 34/136 (25%), Positives = 65/136 (47%), Gaps = 3/136 (2%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           + K R R  +R R R +DR R +   ++R + R+   + S  +S ++R   RE  +    
Sbjct: 214 QSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKER 273

Query: 443 RHRASREKEERHRERRHREKEETRHK---SSRSNSRRRHESEEGDSHRRHKHKKSKRSKE 499
                REKE    + R +EKE  ++K     R   R + + ++ +  R  +H+K +  ++
Sbjct: 274 VKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEK 333

Query: 500 GKEAGSEPAPEQESTE 515
            KE   E   E++ ++
Sbjct: 334 EKEQDKEKEREKDRSK 349



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 43/162 (26%), Positives = 69/162 (42%), Gaps = 30/162 (18%)

Query: 384 EKDRDRERDR--DRERDRDRDRERERTRERERERDHSPTPSVFN-------SDEERYRYR 434
           EKDRD+E+++  D+E++R++DR +E   +R++++     P  +N       S  ER R R
Sbjct: 326 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 385

Query: 435 EYAE--------------------RGYERHRASREKEERH-RERRHREKEETRHKSSRSN 473
             +                     R   +    REKE  H  ERR RE+  +  KSS   
Sbjct: 386 SRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDR 445

Query: 474 SRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTE 515
             +    +   S +  +H K   S   KE   + AP  E  +
Sbjct: 446 DGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 487



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 31/133 (23%), Positives = 58/133 (43%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           R + +DR R +   + R + RER ++R R   RD          ++ER + ++  +    
Sbjct: 226 RSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERER 285

Query: 443 RHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKE 502
                +EKE    + R +E+E+ R K    +  R  E E      + K K+  + KE ++
Sbjct: 286 EKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK 345

Query: 503 AGSEPAPEQESTE 515
             S+   E+   +
Sbjct: 346 DRSKEIDEKRKKD 358



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 35/121 (28%), Positives = 61/121 (50%), Gaps = 10/121 (8%)

Query: 380 YARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAER 439
           + +R K R+R + R R   RD+   R+ TRE+ +E++      V   D E+ R RE  ER
Sbjct: 239 HKKRSKSRERRKSRSRSHSRDK---RKDTREKIKEKER-----VKEKDREKERERE-KER 289

Query: 440 GYERHRASREKEERHRER-RHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSK 498
             E+ R   +  ++ RE+ R ++KE+ R +       +  + E+     + K ++  RSK
Sbjct: 290 EKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK 349

Query: 499 E 499
           E
Sbjct: 350 E 350


>gi|169167715 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 285

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 45/131 (34%), Positives = 71/131 (54%), Gaps = 10/131 (7%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDR------DRDRERERTRERERERDHSPTPSVFN 425
           D   + +    RE+ RDR+R++DRER R      D+DRE E  ++R+RER+   T    +
Sbjct: 115 DRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRD 174

Query: 426 SDEERYRYREYAERGYERHRASREKEERHRER-RHREKEETRHKSSRSNSRRRHESEEGD 484
            + ER + RE   R  +R R  REKE+R R+R R +E+E+ R++  R   R R +  + +
Sbjct: 175 RERERQKQRE-TRRDRDRER-QREKEDRERDRDRQKEREKDRYR-ERETGRDRDKERDRE 231

Query: 485 SHRRHKHKKSK 495
             R     + K
Sbjct: 232 RQREKDRDRQK 242



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 44/149 (29%), Positives = 76/149 (51%), Gaps = 16/149 (10%)

Query: 372 DTSKQWDYYARREKDRDR------ERDRDRERDRDRDRERERTRERERERDHSPTPSV-- 423
           D  ++ D   +R +DRDR      +RDR+ E +R  +RER+R R+RE++R+      +  
Sbjct: 89  DRQRKRDRERQRWRDRDRKRERWGDRDRETETERQEERERQRDRKREKDRERQRQREIGI 148

Query: 424 -----FNSDEERYRYREYAERGYERHR-ASREKEERHRERRHREKEETRHKSSRSNSRRR 477
                  ++++R R RE  E   ER+R   RE++++   RR R++E  R K  R   R R
Sbjct: 149 DKDREIETEKDRDREREMGET--ERYRDRERERQKQRETRRDRDRERQREKEDRERDRDR 206

Query: 478 HESEEGDSHRRHKHKKSKRSKEGKEAGSE 506
            +  E D +R  +  + +  +  +E   E
Sbjct: 207 QKEREKDRYRERETGRDRDKERDRERQRE 235



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 43/166 (25%), Positives = 81/166 (48%), Gaps = 14/166 (8%)

Query: 360 LPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSP 419
           L GS  +   + +  +Q +   +R++ ++R R++DRE ++DRDR+R+R RER+R RD   
Sbjct: 47  LRGSRVAPAIIRERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDR 106

Query: 420 TPSVFNSDEERYRYREYAERGYERHRASREKEERHRER-------------RHREKEETR 466
               +   +         ER  +R R   +  ER R+R             + R++E   
Sbjct: 107 KRERWGDRDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREM 166

Query: 467 HKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQE 512
            ++ R   R R   ++ ++ RR + ++ +R KE +E   +   E+E
Sbjct: 167 GETERYRDRERERQKQRET-RRDRDRERQREKEDRERDRDRQKERE 211



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 49/149 (32%), Positives = 69/149 (46%), Gaps = 24/149 (16%)

Query: 383 REKDRDRERDRDRER--------DRDRDRERERTRERERERDHSPTPSVFNSDEERYRYR 434
           R++ RDRER R R+R        DRDR+ E ER  ERER+RD          D ER R R
Sbjct: 90  RQRKRDRERQRWRDRDRKRERWGDRDRETETERQEERERQRDRKR-----EKDRERQRQR 144

Query: 435 EY---------AERGYERHRASREKEE-RHRERRHREKEETRHKSSRSNSRRRHESEEGD 484
           E           E+  +R R   E E  R RER  +++ ETR    R   R + + E   
Sbjct: 145 EIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRETRRDRDRERQREKEDRERDR 204

Query: 485 SHRRHKHKKSKRSKE-GKEAGSEPAPEQE 512
             ++ + K   R +E G++   E   E++
Sbjct: 205 DRQKEREKDRYRERETGRDRDKERDRERQ 233



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 32/87 (36%), Positives = 49/87 (56%), Gaps = 1/87 (1%)

Query: 384 EKDRDRERDR-DRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           EKDRDRER+  + ER RDR+RER++ RE  R+RD        + + +R R +E  +  Y 
Sbjct: 157 EKDRDREREMGETERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYR 216

Query: 443 RHRASREKEERHRERRHREKEETRHKS 469
                R++++     R REK+  R K+
Sbjct: 217 ERETGRDRDKERDRERQREKDRDRQKA 243



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 41/151 (27%), Positives = 72/151 (47%), Gaps = 25/151 (16%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYRE------- 435
           RE++R RER+R R+R ++R RE++R  E++R+R           D ER R+R+       
Sbjct: 58  RERERQRERERQRKRAKERHREKDREIEKDRDRQRK-------RDRERQRWRDRDRKRER 110

Query: 436 --------YAERGYERHRASREKEERHRERRHREK---EETRHKSSRSNSRRRHESEEGD 484
                     ER  ER R    K E+ RER+ + +   ++ R   +  +  R  E  E +
Sbjct: 111 WGDRDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETE 170

Query: 485 SHRRHKHKKSKRSKEGKEAGSEPAPEQESTE 515
            +R  + ++ K+ +  ++   E   E+E  E
Sbjct: 171 RYRDRERERQKQRETRRDRDRERQREKEDRE 201



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 23/50 (46%), Positives = 34/50 (68%), Gaps = 2/50 (4%)

Query: 372 DTSKQWDYYARREKDRDRERD--RDRERDRDRDRERERTRERERERDHSP 419
           D  +  D    REKDR RER+  RDR+++RDR+R+RE+ R+R++  D  P
Sbjct: 199 DRERDRDRQKEREKDRYRERETGRDRDKERDRERQREKDRDRQKAIDCVP 248


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 3/154 (1%)

Query: 361 PGSAPSWPSLVDTSKQWDYYARRE--KDRDRERDRDRERDRDRDRERERTRERERERDHS 418
           P + P W S +   ++ +   R+E  K+R+ ER ++R     R RERE+ R+RER +   
Sbjct: 28  PCTQPGWQSEI-REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEK 86

Query: 419 PTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRH 478
                    E + R RE   +  E     ++KE++ R R  +E +E   K  R    R+ 
Sbjct: 87  KGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKE 146

Query: 479 ESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQE 512
              + +   + + +K ++ +E K+ G +    +E
Sbjct: 147 RERKKEEREKERERKERKKRERKQVGEKEEERKE 180



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 37/130 (28%), Positives = 65/130 (50%), Gaps = 9/130 (6%)

Query: 374 SKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRY 433
           +K+ +   +R+K   +ER R  +  ++R+R+ ER RE  +ER+           EER + 
Sbjct: 106 NKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERE--------RKKEEREKE 157

Query: 434 REYAERGYERHRASREKEERHRERRHRE-KEETRHKSSRSNSRRRHESEEGDSHRRHKHK 492
           RE  ER     +   EKEE  +E+  +E K+  R++  R   R R E  E    R+ K +
Sbjct: 158 RERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEE 217

Query: 493 KSKRSKEGKE 502
           + K  ++ ++
Sbjct: 218 RKKERQKDRQ 227



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 39/120 (32%), Positives = 63/120 (52%), Gaps = 3/120 (2%)

Query: 381 ARREKDRDRERDRDRERDRDRDRER-ERTRERER-ERDHSPTPSVFNSDEERYRYREYAE 438
           ++  K+R+R+ +R RE  ++R+R++ ER +ERER ER       V   +EER        
Sbjct: 127 SKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKER 186

Query: 439 RGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSK 498
           +  ER+R  R+KE   +ERR R+KE  + K  R   R++          R K ++ +R K
Sbjct: 187 KKRERNRKERKKERERKERRERKKER-KKKEERKKERQKDRQTNWREKERGKRERKERKK 245



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 38/126 (30%), Positives = 60/126 (47%), Gaps = 4/126 (3%)

Query: 382 RREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGY 441
           ++E+ R  +  ++RER  +R RE  + RER++E              ER +  E  E   
Sbjct: 120 KKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERK 179

Query: 442 ERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKE-G 500
           E+ R  R+K ER+R+ R +E+E    K  R   + R + EE    R+   + + R KE G
Sbjct: 180 EKERKERKKRERNRKERKKERE---RKERRERKKERKKKEERKKERQKDRQTNWREKERG 236

Query: 501 KEAGSE 506
           K    E
Sbjct: 237 KRERKE 242



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 25/105 (23%), Positives = 51/105 (48%), Gaps = 12/105 (11%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
           +  K+ +   R++++R +  +++ ER     +ER++     +ER            +ER 
Sbjct: 153 EREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKER-----------KKERE 201

Query: 432 RYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRR 476
           R +E  ER  ER +    K+ER ++R+   +E+ R K  R   ++
Sbjct: 202 R-KERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245


>gi|71044479 death inducer-obliterator 1 isoform c [Homo sapiens]
          Length = 2240

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 73/255 (28%), Positives = 100/255 (39%), Gaps = 37/255 (14%)

Query: 271  SATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPP------PG 324
            SA   + N   P  F   G  P  + P P            PL+  P  PP         
Sbjct: 1995 SAPFSEKNEQTPSRFHFQGQAPQVMKPGP-----------RPLLELPSHPPQHRKDRWEE 2043

Query: 325  APPPSLIPTIESGHS-------SGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQW 377
            A PPS + +   G         +  D R  +   Y N  F                 ++ 
Sbjct: 2044 AGPPSALSSSAPGQGPEADGQWASADFREGKGHEYRNQTFEGRQRERFDVGPKEKPLEEP 2103

Query: 378  DYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYA 437
            D   R  +DR RER+R R   R+RD +R R  +R R++D S        D +R R R  A
Sbjct: 2104 DAQGRASEDRRRERERGRNWSRERDWDRPREWDRHRDKDSS-------RDWDRNRERS-A 2155

Query: 438  ERGYERHRASREKEERHRER-RHREKEETRHKS-SRSNSRRRHESEEGDSHRRHKHKKSK 495
             R  ER     ++ +R RER R+RE+E  R +   RS SR R   +  D  R    K   
Sbjct: 2156 NRDREREADRGKEWDRSRERSRNRERERDRRRDRDRSRSRERDRDKARDRERGRDRKDRS 2215

Query: 496  RSKEGKEAGSEPAPE 510
            +S   KE+  +P PE
Sbjct: 2216 KS---KESARDPKPE 2227



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 38/109 (34%), Positives = 54/109 (49%), Gaps = 16/109 (14%)

Query: 372  DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
            D+S+ WD    R  +RDRER+ DR ++ DR RER R RERER+R           D +R 
Sbjct: 2142 DSSRDWDRNRERSANRDREREADRGKEWDRSRERSRNRERERDR---------RRDRDRS 2192

Query: 432  RYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHES 480
            R R       ER R      ER R+R+ R K +   +  +  + R  ++
Sbjct: 2193 RSR-------ERDRDKARDRERGRDRKDRSKSKESARDPKPEASRASDA 2234



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 33/113 (29%), Positives = 56/113 (49%), Gaps = 9/113 (7%)

Query: 375  KQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYR 434
            + WD     ++ RD++  RD +R+R+R   R+R RE +R ++       ++   ER R R
Sbjct: 2127 RDWDRPREWDRHRDKDSSRDWDRNRERSANRDREREADRGKE-------WDRSRERSRNR 2179

Query: 435  EYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHR 487
            E  ER   R R      ER R++  R++E  R +  RS S+      + ++ R
Sbjct: 2180 E-RERDRRRDRDRSRSRERDRDKA-RDRERGRDRKDRSKSKESARDPKPEASR 2230



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 45/177 (25%), Positives = 65/177 (36%), Gaps = 39/177 (22%)

Query: 287  PPGAPPTHLPPPPFLPPPP---TVSTAPPLIPPPGFPPPPGAPPPSLIPTIES------- 336
            PPG+PP    PPP LP PP    +S+  P  P P       A   +   +  S       
Sbjct: 1257 PPGSPP----PPPPLPEPPVLKVLSSLKPAAPSPATAATTAAAASTAASSTASSASKTAS 1312

Query: 337  ----------GHSSGYDSRSARAFPYGNVAFPHLP-----GSAPSWPSLVDTSKQWDYYA 381
                      G    +D  SAR  P      P  P        P+ P L    +Q+  ++
Sbjct: 1313 PLEHILQTLFGKKKSFDP-SAREPPGSTAGLPQEPKTTAEDGVPAPPLLDPIVQQFGQFS 1371

Query: 382  RREKDRDRERDRDRERDRDRDRER-------ERTRERERERDHSPTPSVFNSDEERY 431
            + +   + E DR  + + + D ER       ER R  E ER  +P  +    +E  Y
Sbjct: 1372 KDKALEEEEDDRPYDPEEEYDPERAFDTQLVERGRRHEVER--APEAAAAEREEVAY 1426


>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo
           sapiens]
          Length = 1792

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 70/273 (25%), Positives = 103/273 (37%), Gaps = 47/273 (17%)

Query: 268 SERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPP--PPGA 325
           SERS      +    P F P       +PPPP  PPPP     PP +PPP F P  PPG 
Sbjct: 539 SERSQRTQGPSLPATPVFVP-------VPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQ 591

Query: 326 PPPSLIPTIESGHSSGYDSRSARAFP--YGNVAFPHLPGSAPSWPSLVDTSKQWDYYARR 383
           PPP           +GY S     FP    N++ P +     +  S    + Q    +R 
Sbjct: 592 PPP-----------AGY-SVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSRE 639

Query: 384 EKDRDRERDRDRERDRDRDRE------------RERTRERERERDHSPTP---SVFNSDE 428
           E  R++ R ++ E+ + +  E            ++  +ER R    S +P   S ++   
Sbjct: 640 EFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSS 699

Query: 429 ERY--------RYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHES 480
             Y        R R Y+ R + R  +          RR R K       SRS+   R  S
Sbjct: 700 YTYSKSRSGSTRSRSYS-RSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRS 758

Query: 481 EEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQES 513
                 R H   +S ++  G+       P+ E+
Sbjct: 759 RSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGET 791



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 25/105 (23%), Positives = 53/105 (50%), Gaps = 5/105 (4%)

Query: 413  RERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEE-TRHKSSR 471
            R + HS +PSV  S    +       R +    +S E ++  ++++ +EK++  +HK  +
Sbjct: 1689 RNQSHS-SPSV--SPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHK 1745

Query: 472  SNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEA 516
             + +      E +  ++HKHKK K+SK+ K+   E   + +  ++
Sbjct: 1746 KHKKHAGTEVELEKSQKHKHKK-KKSKKNKDKEKEKEKDDQKVKS 1789



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 42/161 (26%), Positives = 65/161 (40%), Gaps = 28/161 (17%)

Query: 379 YYARREKDRDR-ERDRDRERDRDRDRERER----------TRERERERDHSPTP----SV 423
           YY R    RD  E++R RE +R      E+           R      + SP      ++
Sbjct: 811 YYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNI 870

Query: 424 FNSDEERYRYREYAERGYERHRA----SREKEERHRERRHREKEETRHKSSRSNSRRRHE 479
            NS   R R  +Y   G + HR+    S   E+      H +K+ T+ K   S      E
Sbjct: 871 RNSPFTRGRREDYV--GGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKES------E 922

Query: 480 SEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE 520
           +  GD  + +KHKK ++ ++G+E+     PE   T     E
Sbjct: 923 NAPGDG-KGNKHKKHRKRRKGEESEGFLNPELLETSRKSRE 962



 Score = 33.5 bits (75), Expect = 0.48
 Identities = 22/95 (23%), Positives = 44/95 (46%), Gaps = 21/95 (22%)

Query: 405  RERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEE 464
            R  +    + R HS + S   S +                  S++K+++  +++H  K+ 
Sbjct: 1702 RSHSPSGSQTRSHSSSASSAESQD------------------SKKKKKKKEKKKH--KKH 1741

Query: 465  TRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKE 499
             +HK  + ++    E E+   H +HK KKSK++K+
Sbjct: 1742 KKHKKHKKHAGTEVELEKSQKH-KHKKKKSKKNKD 1775



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 29/154 (18%), Positives = 64/154 (41%), Gaps = 7/154 (4%)

Query: 373  TSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYR 432
            T ++ D  A  +K+   +  +  +   D +RER    E   ++    TP   N+      
Sbjct: 1019 TKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSS 1078

Query: 433  YREYAERGYERHRASREKEERHRERRHREKEETRH------KSSRSNSRRRHESEEGDSH 486
             ++    G  R   S+  +E H+E +  ++E+ +       KS +  ++     +  + +
Sbjct: 1079 QKDEKITGTPRKAHSKSAKE-HQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKN 1137

Query: 487  RRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE 520
            +   +K  KR ++ +E G +   E  S + +  E
Sbjct: 1138 KPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLE 1171


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 46/149 (30%), Positives = 75/149 (50%), Gaps = 16/149 (10%)

Query: 382 RREKDRDRERDRDRERDRDRD-------RERERTRERERERDHSPTPSVFNSDEER---- 430
           RRE+++ R+R+R++ER R+R        ++RER +ERER+R           ++ER    
Sbjct: 40  RREREK-RKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRK 98

Query: 431 --YRYREYAERGYERHRASREKEERHRERRHR--EKEETRHKSSRSNSRRRHESEEGDSH 486
              + RE  +RG    +  +E++ER RE + R   K + R K  R   R+R +       
Sbjct: 99  KEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRER 158

Query: 487 RRHKHKKSKRSKEGKEAGSEPAPEQESTE 515
           +R K KK +R K+ +    E   E+E  E
Sbjct: 159 KRKKRKKEEREKKRERNRKERKKERERKE 187



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 35/122 (28%), Positives = 65/122 (53%), Gaps = 1/122 (0%)

Query: 382 RREKDRDRERDRDRERDRDRDRERERTRERER-ERDHSPTPSVFNSDEERYRYREYAERG 440
           RREK+R + +   ++R+R +   RER +++ER ER+           ++R + +   ER 
Sbjct: 89  RREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERK 148

Query: 441 YERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEG 500
            E+ R  RE++ + R++  REK+  R++  R   R R E  E    R+ + +K K  K+ 
Sbjct: 149 REKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKD 208

Query: 501 KE 502
           ++
Sbjct: 209 RK 210



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 43/122 (35%), Positives = 66/122 (54%), Gaps = 6/122 (4%)

Query: 382 RREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAER-- 439
           +RE +R +ER R+RE+ R R+RE+ER RER ++            + ER R     +R  
Sbjct: 31  QRESERKKER-REREK-RKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKE 88

Query: 440 GYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKE 499
             E+ R  R+KE++ RER+ R + E + K  R    R  E+++    +R K +K KR KE
Sbjct: 89  RREKERRKRKKEKKKRERKQRGRRERKKKKER--KERERENKQRRERKRKKRRKKKRRKE 146

Query: 500 GK 501
            K
Sbjct: 147 RK 148



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 36/137 (26%), Positives = 66/137 (48%), Gaps = 4/137 (2%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           REK R   R+++R + +   ++RER +   RER           + ++ R R+  +R  +
Sbjct: 82  REKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKK 141

Query: 443 RHRASREKEE----RHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSK 498
           + R  R++E+    R R+R+ R+KEE   K  R+   R+ E E  +   R K +K +R K
Sbjct: 142 KRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRK 201

Query: 499 EGKEAGSEPAPEQESTE 515
           + +         Q  ++
Sbjct: 202 KKERKKDRKTDRQTDSQ 218



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 41/125 (32%), Positives = 65/125 (52%), Gaps = 17/125 (13%)

Query: 382 RREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGY 441
           RRE+ + +ER ++RER+  + RER+R + R+++R            +ER R +E  +R  
Sbjct: 111 RRERKKKKER-KERERENKQRRERKRKKRRKKKRR-----------KERKREKERGKR-- 156

Query: 442 ERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGK 501
           ER R  R+KEER ++R    KE    K  R    RR   +E    RR K ++ K  K  +
Sbjct: 157 ERKRKKRKKEEREKKRERNRKE---RKKERERKERRERKKERKKERRKKKERKKDRKTDR 213

Query: 502 EAGSE 506
           +  S+
Sbjct: 214 QTDSQ 218



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 32/114 (28%), Positives = 57/114 (50%), Gaps = 4/114 (3%)

Query: 393 RDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEE 452
           R+ ER ++R    +R RERE+ER            ++R R +E   +  ER +  +E+ E
Sbjct: 32  RESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERRE 91

Query: 453 RHRERRHREKEETRHKS----SRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKE 502
           + R +R +EK++   K      R   + R E E  +  RR + +K +R K+ ++
Sbjct: 92  KERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRK 145



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 32/120 (26%), Positives = 57/120 (47%), Gaps = 9/120 (7%)

Query: 396 ERDRDRDRE------RERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASRE 449
           +R+ +R +E      R+R RE+ER+R+            ER + RE   +  E+ R  R 
Sbjct: 31  QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90

Query: 450 KEERHRERRHREKEETRHKSSRSNSRRRHESE---EGDSHRRHKHKKSKRSKEGKEAGSE 506
           ++ER + ++ ++K E + +  R   +++   E   E    R  K KK ++ K  KE   E
Sbjct: 91  EKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKRE 150



 Score = 37.0 bits (84), Expect = 0.044
 Identities = 16/56 (28%), Positives = 29/56 (51%)

Query: 447 SREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKE 502
           ++ + ER +ERR REK +   +  R   R + E ++     R K ++ KR +  K+
Sbjct: 30  TQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQ 85



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 14/66 (21%), Positives = 30/66 (45%)

Query: 447 SREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSE 506
           S+   +R  ER+   +E  + K  R   R+R   ++    R+ + +  +R ++ KE   +
Sbjct: 26  SKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQ 85

Query: 507 PAPEQE 512
               +E
Sbjct: 86  RKERRE 91



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 10/41 (24%), Positives = 28/41 (68%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERE 412
           +  K+ +   RRE+ ++R+++R ++++R +DR+ +R  + +
Sbjct: 178 ERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218


>gi|7662018 PHD finger protein 3 [Homo sapiens]
          Length = 2039

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 63/222 (28%), Positives = 100/222 (45%), Gaps = 35/222 (15%)

Query: 283  PPFFPP----GAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIES-- 336
            PP FPP    G PP HLPPP  LPPP       P++P P     PG P   + P  ++  
Sbjct: 1820 PPNFPPQSMFGFPP-HLPPP-LLPPPGFGFAQNPMVPWPPVVHLPGQPQRMMGPLSQASR 1877

Query: 337  --GHSSGYDSRSAR------AFPYG-----NVAFPHLPGSAPSWPSLVDT--------SK 375
              G  + Y  +  R      + P+G      +  P   G         D+         K
Sbjct: 1878 YIGPQNFYQVKDIRRPERRHSDPWGRQDQQQLDRPFNRGKGDRQRFYSDSHHLKRERHEK 1937

Query: 376  QWDYYARREKDRDRERDRDRER----DRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
            +W+  + R + RDR +D+DR+R    +  +D+ER R    +R  D   +    N D++  
Sbjct: 1938 EWEQESERHRRRDRSQDKDRDRKSREEGHKDKERARLSHGDRGTDGKASRDSRNVDKKPD 1997

Query: 432  RYR-EYAERGYERHRASREKEERHRERRHREKEET-RHKSSR 471
            + + E  E+  ER ++   + E+ R+R H++++ T R KS R
Sbjct: 1998 KPKSEDYEKDKEREKSKHREGEKDRDRYHKDRDHTDRTKSKR 2039


>gi|146134388 YLP motif containing 1 [Homo sapiens]
          Length = 2146

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 54/170 (31%), Positives = 81/170 (47%), Gaps = 19/170 (11%)

Query: 295  LPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGN 354
            +P  P LPPPP  S+ PP  P P   PP   PPP +  T++ GH     +      PYG 
Sbjct: 1602 IPSAPVLPPPPVHSSIPPPGPVPMGMPPMSKPPP-VQQTVDYGHGRDISTNKVEQIPYGE 1660

Query: 355  VAFPHLPGSAPSWPSL-VDTSKQWDYYARREKDRDRERDRDRERD-----RDRDRERERT 408
                  P   P   +   + + Q D Y   +++RDRE   DR+ +     RD  R+RE  
Sbjct: 1661 -RITLRPDPLPERSTFETEHAGQRDRY---DRERDREPYFDRQSNVIADHRDFKRDRETH 1716

Query: 409  RERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERR 458
            R+R+R+R       V + D +R+  RE   R  +R ++ R+K++    RR
Sbjct: 1717 RDRDRDR------GVIDYDRDRFD-RERRPRD-DRAQSYRDKKDHSSSRR 1758



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 32/72 (44%), Positives = 37/72 (51%), Gaps = 13/72 (18%)

Query: 278 NFSKPPPFFPPGAPPTHLP--PPPFLPP---PPTVSTA-PPLIPPPGFPP-------PPG 324
           N S PPPF P    P  LP  PPP LPP   PP +  A P  +PPPG PP       P  
Sbjct: 513 NMSMPPPFVPYSQMPPPLPTMPPPVLPPSLPPPVMPPALPATVPPPGMPPPVMPPSLPTS 572

Query: 325 APPPSLIPTIES 336
            PPP + P++ S
Sbjct: 573 VPPPGMPPSLSS 584



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 28/63 (44%), Positives = 32/63 (50%), Gaps = 14/63 (22%)

Query: 282 PPPFFPPGAPPTHLPP-------PPFLPPPPTVSTAPPLIPPPGFP-------PPPGAPP 327
           PPP  PP  PP  +PP       PP +PPP    + P  +PPPG P       PPP  PP
Sbjct: 534 PPPVLPPSLPPPVMPPALPATVPPPGMPPPVMPPSLPTSVPPPGMPPSLSSAGPPPVLPP 593

Query: 328 PSL 330
           PSL
Sbjct: 594 PSL 596



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 44/114 (38%), Positives = 48/114 (42%), Gaps = 32/114 (28%)

Query: 280 SKPPPFFPPG----APPTHLPPP--------PFLPPPPTVSTAPPLI----------PPP 317
           S PPP  PP      PP  LPPP        P LPPP   STAPP +          PPP
Sbjct: 572 SVPPPGMPPSLSSAGPPPVLPPPSLSSAGPPPVLPPPSLSSTAPPPVMPLPPLSSATPPP 631

Query: 318 GFPPP--PGAPPPSL----IPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAP 365
           G PPP  P   PP L    +P   S  SS    +   A     V+F    GSAP
Sbjct: 632 GIPPPGVPQGIPPQLTAAPVPPASSSQSSQVPEKPRPALLPTPVSF----GSAP 681



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 76/273 (27%), Positives = 103/273 (37%), Gaps = 92/273 (33%)

Query: 278  NFSKPPPFFPPGAPPTHLPPPPFLPPPPTVS-------------TAPPL-IPPPGFPPPP 323
            N S  P  +PP  P ++ PPPP   PP ++              T PP+ IPPP  PPP 
Sbjct: 1498 NTSSRPGMYPP--PGSYRPPPPMGKPPGSIVRPSAPPARSSVPVTRPPVPIPPPPPPPPL 1555

Query: 324  GAPPPSLIPTI---------------------ESGHSSGYDSRSARAFPYGNVAFP---- 358
              PPP + P                       E G +S + S +A A P   V  P    
Sbjct: 1556 PPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNSEFKSETA-AIPSAPVLPPPPVH 1614

Query: 359  ---HLPGSAP------SWPSLVDTSKQWDY-------------YARR------------- 383
                 PG  P      S P  V  +  + +             Y  R             
Sbjct: 1615 SSIPPPGPVPMGMPPMSKPPPVQQTVDYGHGRDISTNKVEQIPYGERITLRPDPLPERST 1674

Query: 384  -EKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERG-- 440
             E +   +RDR    DR+RDRE    R+     DH      F  D E +R R+  +RG  
Sbjct: 1675 FETEHAGQRDR---YDRERDREPYFDRQSNVIADHRD----FKRDRETHRDRD-RDRGVI 1726

Query: 441  -YERHRASREKEER-HRERRHREKEETRHKSSR 471
             Y+R R  RE+  R  R + +R+K++  H SSR
Sbjct: 1727 DYDRDRFDRERRPRDDRAQSYRDKKD--HSSSR 1757



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 36/102 (35%), Positives = 46/102 (45%), Gaps = 19/102 (18%)

Query: 287 PPGAPPTHLPPPPFLPP-------PPTVSTAPPLIPPPGFPP--------PPGAPPPSLI 331
           PPG  P  L  PP  PP       PP+ S  PP  PPP + P        PP  P PS  
Sbjct: 135 PPGLVPMELESPPESPPVPPGSYMPPSQSYMPPPQPPPSYYPPTSSQPYLPPAQPSPSQS 194

Query: 332 PTIES--GHSSGYDSRSARAFPYGNVAFPHLPGS--APSWPS 369
           P  +S    +  Y S S+ +  Y + +  +LP S  +PS PS
Sbjct: 195 PPSQSYLAPTPSYSSSSSSSQSYLSHSQSYLPSSQASPSRPS 236



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 34/129 (26%), Positives = 56/129 (43%), Gaps = 21/129 (16%)

Query: 377  WDYYARREKDRDRERDRDRERDRDRDRE----------RERTRERERERDHSPTPSVFNS 426
            WD +   E+D+D + D +RE +RD DR+           +R+ + E +RD+       + 
Sbjct: 1265 WDDW---ERDQDMDEDYNREMERDMDRDVDRISRPMDMYDRSLDNEWDRDYG---RPLDE 1318

Query: 427  DEERYRYREYAERG-----YERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESE 481
             E ++R R+                 R +++R RE R+RE    R    R   R R   E
Sbjct: 1319 QESQFRERDIPSLPPLPPLPPLPPLDRYRDDRWREERNREHGYDRDFRDRGELRIREYPE 1378

Query: 482  EGDSHRRHK 490
             GD+ R  +
Sbjct: 1379 RGDTWREKR 1387



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 21/41 (51%), Positives = 24/41 (58%), Gaps = 12/41 (29%)

Query: 292 PTHLPPPPFLPPPPTVSTAPPLIPPPGF----PPPPGAPPP 328
           P HLPPPP LPPPP       ++P  G+    PPPP  PPP
Sbjct: 78  PHHLPPPP-LPPPP-------VMPGGGYGDWQPPPPPMPPP 110



 Score = 38.1 bits (87), Expect = 0.020
 Identities = 28/93 (30%), Positives = 32/93 (34%), Gaps = 38/93 (40%)

Query: 282 PPPFFPPGAPPTHLPPPPFLPPPPTVSTA-------------------PPLIP-----PP 317
           PPP  P G      PPPP +PPPP  + +                   P L+P     PP
Sbjct: 88  PPPVMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMLHHQRDGPPGLVPMELESPP 147

Query: 318 GFPP--------------PPGAPPPSLIPTIES 336
             PP              PP  PPPS  P   S
Sbjct: 148 ESPPVPPGSYMPPSQSYMPPPQPPPSYYPPTSS 180



 Score = 37.4 bits (85), Expect = 0.033
 Identities = 18/38 (47%), Positives = 19/38 (50%), Gaps = 3/38 (7%)

Query: 287 PPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPG 324
           P   PP  LPPPP +P        P   PPP  PPPPG
Sbjct: 78  PHHLPPPPLPPPPVMPGGGYGDWQP---PPPPMPPPPG 112



 Score = 33.5 bits (75), Expect = 0.48
 Identities = 18/48 (37%), Positives = 21/48 (43%), Gaps = 4/48 (8%)

Query: 293 THLPPPPFLPPPPTVSTAPPLIPPPGF--PPPPGAPPPSLIPTIESGH 338
           +H PPPP  PPPP     P   P PG+     P AP  S   +    H
Sbjct: 12  SHYPPPPVPPPPPV--ALPEASPGPGYSSSTTPAAPSSSGFMSFREQH 57



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 20/51 (39%), Positives = 25/51 (49%), Gaps = 6/51 (11%)

Query: 294  HLPPPPFLPPPPTVSTAPPLIPPPGF---PPPPGAPPPSLI-PTIESGHSS 340
            HLPP          S+ P + PPPG    PPP G PP S++ P+     SS
Sbjct: 1488 HLPPQE--SRLQNTSSRPGMYPPPGSYRPPPPMGKPPGSIVRPSAPPARSS 1536



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 27/103 (26%), Positives = 38/103 (36%), Gaps = 38/103 (36%)

Query: 282 PPPFFPPGAPPTHLPP--------PP---FLPPPPTVST--------------------A 310
           PP ++PP +   +LPP        PP   +L P P+ S+                    A
Sbjct: 171 PPSYYPPTSSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYLSHSQSYLPSSQA 230

Query: 311 PPLIPPPGF-------PPPPGAPPPSLIPTIESGHSSGYDSRS 346
            P  P  G        PPPP APP +     +    SG  ++S
Sbjct: 231 SPSRPSQGHSKSQLLAPPPPSAPPGNKTTVQQEPLESGAKNKS 273



 Score = 29.3 bits (64), Expect = 9.1
 Identities = 31/106 (29%), Positives = 41/106 (38%), Gaps = 29/106 (27%)

Query: 282 PPPFFPPGAPP--THLPPPP----------------FLPPPPTVSTAPPLIPPPGFPPPP 323
           PPP  P G PP  T  P PP                 LP P +  +APP      + PP 
Sbjct: 634 PPPGVPQGIPPQLTAAPVPPASSSQSSQVPEKPRPALLPTPVSFGSAPPTT----YHPPL 689

Query: 324 GAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPS 369
            +  PS     E  +S    S+S  A PY + +     G + + PS
Sbjct: 690 QSAGPS-----EQVNSKAPLSKS--ALPYSSFSSDQGLGESSAAPS 728


>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
          Length = 715

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 43/150 (28%), Positives = 66/150 (44%), Gaps = 6/150 (4%)

Query: 372 DTSKQWDYYARREKDRDRE----RDRDRERDRDRDRERERTRERERERDHSPTPSVFNSD 427
           D S+    Y  R++ R R     RD  R R  ++ R+R R+R   +ERDHS   S  + +
Sbjct: 436 DCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSP-SKE 494

Query: 428 EERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRR-RHESEEGDSH 486
            +  R R  ++    R   S  KE  HR  R   KE  R +S   N  R R +S      
Sbjct: 495 RDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEE 554

Query: 487 RRHKHKKSKRSKEGKEAGSEPAPEQESTEA 516
           R H+  +S   +  +     P+ E+E  ++
Sbjct: 555 REHRQSRSPSKERDRRRWRSPSKERERRQS 584



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 43/172 (25%), Positives = 71/172 (41%), Gaps = 14/172 (8%)

Query: 361 PGSAPSWPSLVDTSKQWDYYARREKDRDRE--------RDRDRERDRDRDRERERTRERE 412
           P        L   SK+ D+   R   ++R+        ++RD  R R   +ER+R + R 
Sbjct: 479 PSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRS 538

Query: 413 RERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRS 472
             ++   + S   S+E  +R      +  +R R     +ER R +     EE  H  SRS
Sbjct: 539 PNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRS 598

Query: 473 NSRRRHESEEGDSHRRHKHKKSKR-SKEGKEAGS-----EPAPEQESTEATP 518
            +++   S    S +   H +S+  SKEG  + S     E  P Q +   +P
Sbjct: 599 PNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSP 650



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 35/140 (25%), Positives = 63/140 (45%), Gaps = 6/140 (4%)

Query: 385 KDRDRERDRDRERDRDRDRERERTRERERERDHSPTP------SVFNSDEERYRYREYAE 438
           K RDR R R   ++RD  +    ++ER+  R  SP+       S  +S E  +R      
Sbjct: 469 KARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPS 528

Query: 439 RGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSK 498
           +  +R ++    +ER R +     EE  H+ SRS S+ R         +  + ++S+ S 
Sbjct: 529 KERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSS 588

Query: 499 EGKEAGSEPAPEQESTEATP 518
           E ++     +P ++S  + P
Sbjct: 589 EERDHSRSRSPNKQSGYSRP 608



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 42/150 (28%), Positives = 65/150 (43%), Gaps = 6/150 (4%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRD----RERERTRERERERDHSPTPSVFNSD 427
           D S+    Y  R++ R R  ++ R+  R R     R+R R+R   + RDHS + S  N  
Sbjct: 412 DRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSP-NKA 470

Query: 428 EERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHR 487
            +R R R  ++        S  KE  HR  R   KE    +S  S+  R H      S  
Sbjct: 471 RDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKE 530

Query: 488 RHKHKKSKRSKEGKEAGS-EPAPEQESTEA 516
           R + +    +KE   + S  P+ E+E  ++
Sbjct: 531 RQRRQSRSPNKERDRSQSRSPSEEREHRQS 560



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 40/160 (25%), Positives = 73/160 (45%), Gaps = 15/160 (9%)

Query: 374 SKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRY 433
           +KQ D+   R +  ++ RDR R R   + R+R R+R   + RD S + S + + +     
Sbjct: 396 NKQRDH--SRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSR 453

Query: 434 REYAERGYERHRASREKEERHR------ERRHRE----KEETRHKSSRSNSRRRHESEEG 483
                R + R R+  +  +R R      ER H +     +E  H+ SRS S+ R   +  
Sbjct: 454 SPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSR 513

Query: 484 DSHRRHKHKKSKRSKEGKEAGSEPAPEQE---STEATPAE 520
            S +   H++S+   + ++     +P +E   S   +P+E
Sbjct: 514 SSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSE 553



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 29/137 (21%), Positives = 57/137 (41%), Gaps = 14/137 (10%)

Query: 382 RREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGY 441
           R+ +  ++ERDR + R    +RE  ++R   +ERD             R R+R    +  
Sbjct: 534 RQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERD-------------RRRWRS-PSKER 579

Query: 442 ERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGK 501
           ER ++    EER   R     +++ +   R++S+ +  S      +   H +S+ S +  
Sbjct: 580 ERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKES 639

Query: 502 EAGSEPAPEQESTEATP 518
           +      P     + +P
Sbjct: 640 DPSQSTVPRSPDWKRSP 656



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 34/169 (20%), Positives = 66/169 (39%), Gaps = 18/169 (10%)

Query: 362 GSAPSWPSLVDTSKQWDYYARREKDRD--------RERDRDRERDRDRDRERERTRERER 413
           G + +W       +   +     K+RD        +E  R +    ++ R+  R+R   +
Sbjct: 350 GRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNK 409

Query: 414 ERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRER---------RHREKEE 464
            RD S + S + + +          R   R R+  +  +R R R         R R   +
Sbjct: 410 ARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNK 469

Query: 465 TRHKS-SRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQE 512
            R +S SRS S+ R  S+ G   +   H++S+   + ++     +  +E
Sbjct: 470 ARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKE 518



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 39/159 (24%), Positives = 66/159 (41%), Gaps = 26/159 (16%)

Query: 366 SWPSLVDTSKQWDY----YARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTP 421
           S+  ++  S++  Y     + R K  ++   R R +   + R   R+R   ++R HS   
Sbjct: 244 SYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHS--- 300

Query: 422 SVFNSDEERYRYREYA-ERGYERHRASREKE-----ERHRERRHREKEETRHKSSRSNSR 475
                     R R ++ +R + R R+   K       RH + R   K +++++S      
Sbjct: 301 ----------RVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRG 350

Query: 476 RRHE-SEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQES 513
           R H  S      R H H +S  SKE    GS  +P +ES
Sbjct: 351 RSHNWSRNPSKERSHSHSRSS-SKERDHRGSS-SPRKES 387



 Score = 36.6 bits (83), Expect = 0.057
 Identities = 25/127 (19%), Positives = 46/127 (36%), Gaps = 8/127 (6%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           R +    +R+  R R R R     +     + R HS   S   S   R        RG  
Sbjct: 301 RVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPR--------RGRS 352

Query: 443 RHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKE 502
            + +    +ER         +E  H+ S S  +    S+ G  +++  H +S+   + ++
Sbjct: 353 HNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARD 412

Query: 503 AGSEPAP 509
                +P
Sbjct: 413 RSRSRSP 419



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 28/152 (18%), Positives = 59/152 (38%), Gaps = 22/152 (14%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERG-- 440
           + +   + + +++ R   R R    +R   +ER HS + S     + R       E G  
Sbjct: 331 QSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRS 390

Query: 441 ----------YERHRASREKEERHRERR-HREKEETRHKS---------SRSNSRRRHES 480
                     + R R+  +  +R R R  ++ ++ +R +S         SRS  + R  S
Sbjct: 391 QSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRS 450

Query: 481 EEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQE 512
                ++   H +S+   + ++     +P +E
Sbjct: 451 RSRSPNKARDHSRSRSPNKARDRSRSRSPSKE 482



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 21/112 (18%), Positives = 43/112 (38%)

Query: 407 RTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETR 466
           R   R R R  + TPS  ++D    +  + ++    + R +  +      R  R  + + 
Sbjct: 77  RPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSP 136

Query: 467 HKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATP 518
            ++S     R H +  G + R       ++   GK  G      +E +++ P
Sbjct: 137 SRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQP 188


>gi|52426743 cisplatin resistance-associated overexpressed protein
           [Homo sapiens]
          Length = 432

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 50/156 (32%), Positives = 73/156 (46%), Gaps = 24/156 (15%)

Query: 383 REKDRDRERDR----------DRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYR 432
           REK+R+RER+           +RE++R RDRER R R R R R  S T     SD    R
Sbjct: 257 REKEREREREERERKRRREEEEREKERARDRER-RKRSRSRSRHSSRT-----SDRRCSR 310

Query: 433 YREYAERGYERHRASREKEER------HRERRHREKEETRHKS-SRSNSRRRHESEEGDS 485
            R++        R SR ++ R        ER+HR +   R +S SR     +H S+  D 
Sbjct: 311 SRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDR 370

Query: 486 HRRHKHK-KSKRSKEGKEAGSEPAPEQESTEATPAE 520
            +  K K K KR  + K++  +    ++ +E T  E
Sbjct: 371 EQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTE 406



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 47/132 (35%), Positives = 63/132 (47%), Gaps = 22/132 (16%)

Query: 385 KDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERH 444
           + R  E DRD    +++    ER +ERERER+          + ER R RE  ER  ER 
Sbjct: 235 RKRTEEPDRDERLKKEKQEREEREKERERERE----------ERERKRRREEEEREKERA 284

Query: 445 RASREKEERHRER-RHREKEETR-------HKSSRSNSRRRHESEE---GDSHRRHKHKK 493
           R  RE+ +R R R RH  +   R       HK SRS  RRR  S +     SH R + K 
Sbjct: 285 R-DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKH 343

Query: 494 SKRSKEGKEAGS 505
             RS++ + + S
Sbjct: 344 RSRSRDRRRSKS 355



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 39/130 (30%), Positives = 59/130 (45%), Gaps = 15/130 (11%)

Query: 378 DYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYA 437
           D   ++EK    ER+++RER+R+   ERER R RE E            ++ER R RE  
Sbjct: 244 DERLKKEKQEREEREKERERERE---ERERKRRREEEE----------REKERARDRERR 290

Query: 438 ERGYERHRASREKEERH--RERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSK 495
           +R   R R S    +R   R R H+       + SRS  RRR  S +    +     + +
Sbjct: 291 KRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDR 350

Query: 496 RSKEGKEAGS 505
           R  + ++  S
Sbjct: 351 RRSKSRDRKS 360



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 34/134 (25%), Positives = 64/134 (47%), Gaps = 1/134 (0%)

Query: 374 SKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNS-DEERYR 432
           S+    ++ R  DR   R RD +R R R+R R R+R+R R R H  +     S   +R R
Sbjct: 293 SRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRR 352

Query: 433 YREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHK 492
            +    + Y+    SR++E+  + +   ++     KSS  +  R  +SE+ ++  +    
Sbjct: 353 SKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDT 412

Query: 493 KSKRSKEGKEAGSE 506
           K++ +   ++  SE
Sbjct: 413 KNEVNGTSEDIKSE 426



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 43/132 (32%), Positives = 56/132 (42%), Gaps = 27/132 (20%)

Query: 384 EKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYER 443
           E+ +++ R R  E DRD   ++E+    ERE+             ER R RE  ER   R
Sbjct: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREK-------------EREREREERERKRRR 274

Query: 444 HRASREKEE-RHRERRHREKEETRHKS-------------SRSNSRRRHESEEGDSHRRH 489
               REKE  R RERR R +  +RH S              RS SR R  S   D  R  
Sbjct: 275 EEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSR 334

Query: 490 KHKKSKRSKEGK 501
            H +S+R    +
Sbjct: 335 SHDRSERKHRSR 346



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 45/151 (29%), Positives = 67/151 (44%), Gaps = 26/151 (17%)

Query: 382 RREKDRDRERDRDRER---------------DRDRDRERERTRERERERDHSPTPSVFNS 426
           R E++R++ER RDRER               DR   R R+  R R RER  S      + 
Sbjct: 274 REEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSR-----SR 328

Query: 427 DEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKS-SRSNSRRRHESEE-GD 484
           D  R R  + +ER   +HR SR ++ R  + R R+  + R KS  R   R+  E E+ G 
Sbjct: 329 DRRRSRSHDRSER---KHR-SRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGS 384

Query: 485 SHRRHKHKKSKRSKEGKEAGSEPAPEQESTE 515
             ++   K   R K+ ++  +E        E
Sbjct: 385 DDKKSSVKSGSREKQSEDTNTESKESDTKNE 415



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 18/62 (29%), Positives = 33/62 (53%), Gaps = 3/62 (4%)

Query: 372 DTSKQWDYYARREKDRDRERDRD--RERDRDRDRERER-TRERERERDHSPTPSVFNSDE 428
           D S++      R++ R + RDR   + R + RDRE++R ++E+E+        SV +   
Sbjct: 337 DRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSR 396

Query: 429 ER 430
           E+
Sbjct: 397 EK 398


>gi|19923485 cisplatin resistance-associated overexpressed protein
           [Homo sapiens]
          Length = 432

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 50/156 (32%), Positives = 73/156 (46%), Gaps = 24/156 (15%)

Query: 383 REKDRDRERDR----------DRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYR 432
           REK+R+RER+           +RE++R RDRER R R R R R  S T     SD    R
Sbjct: 257 REKEREREREERERKRRREEEEREKERARDRER-RKRSRSRSRHSSRT-----SDRRCSR 310

Query: 433 YREYAERGYERHRASREKEER------HRERRHREKEETRHKS-SRSNSRRRHESEEGDS 485
            R++        R SR ++ R        ER+HR +   R +S SR     +H S+  D 
Sbjct: 311 SRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDR 370

Query: 486 HRRHKHK-KSKRSKEGKEAGSEPAPEQESTEATPAE 520
            +  K K K KR  + K++  +    ++ +E T  E
Sbjct: 371 EQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTE 406



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 47/132 (35%), Positives = 63/132 (47%), Gaps = 22/132 (16%)

Query: 385 KDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERH 444
           + R  E DRD    +++    ER +ERERER+          + ER R RE  ER  ER 
Sbjct: 235 RKRTEEPDRDERLKKEKQEREEREKERERERE----------ERERKRRREEEEREKERA 284

Query: 445 RASREKEERHRER-RHREKEETR-------HKSSRSNSRRRHESEE---GDSHRRHKHKK 493
           R  RE+ +R R R RH  +   R       HK SRS  RRR  S +     SH R + K 
Sbjct: 285 R-DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKH 343

Query: 494 SKRSKEGKEAGS 505
             RS++ + + S
Sbjct: 344 RSRSRDRRRSKS 355



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 39/130 (30%), Positives = 59/130 (45%), Gaps = 15/130 (11%)

Query: 378 DYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYA 437
           D   ++EK    ER+++RER+R+   ERER R RE E            ++ER R RE  
Sbjct: 244 DERLKKEKQEREEREKERERERE---ERERKRRREEEE----------REKERARDRERR 290

Query: 438 ERGYERHRASREKEERH--RERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSK 495
           +R   R R S    +R   R R H+       + SRS  RRR  S +    +     + +
Sbjct: 291 KRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDR 350

Query: 496 RSKEGKEAGS 505
           R  + ++  S
Sbjct: 351 RRSKSRDRKS 360



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 34/134 (25%), Positives = 64/134 (47%), Gaps = 1/134 (0%)

Query: 374 SKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNS-DEERYR 432
           S+    ++ R  DR   R RD +R R R+R R R+R+R R R H  +     S   +R R
Sbjct: 293 SRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRR 352

Query: 433 YREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHK 492
            +    + Y+    SR++E+  + +   ++     KSS  +  R  +SE+ ++  +    
Sbjct: 353 SKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDT 412

Query: 493 KSKRSKEGKEAGSE 506
           K++ +   ++  SE
Sbjct: 413 KNEVNGTSEDIKSE 426



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 43/132 (32%), Positives = 56/132 (42%), Gaps = 27/132 (20%)

Query: 384 EKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYER 443
           E+ +++ R R  E DRD   ++E+    ERE+             ER R RE  ER   R
Sbjct: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREK-------------EREREREERERKRRR 274

Query: 444 HRASREKEE-RHRERRHREKEETRHKS-------------SRSNSRRRHESEEGDSHRRH 489
               REKE  R RERR R +  +RH S              RS SR R  S   D  R  
Sbjct: 275 EEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSR 334

Query: 490 KHKKSKRSKEGK 501
            H +S+R    +
Sbjct: 335 SHDRSERKHRSR 346



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 45/151 (29%), Positives = 67/151 (44%), Gaps = 26/151 (17%)

Query: 382 RREKDRDRERDRDRER---------------DRDRDRERERTRERERERDHSPTPSVFNS 426
           R E++R++ER RDRER               DR   R R+  R R RER  S      + 
Sbjct: 274 REEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSR-----SR 328

Query: 427 DEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKS-SRSNSRRRHESEE-GD 484
           D  R R  + +ER   +HR SR ++ R  + R R+  + R KS  R   R+  E E+ G 
Sbjct: 329 DRRRSRSHDRSER---KHR-SRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGS 384

Query: 485 SHRRHKHKKSKRSKEGKEAGSEPAPEQESTE 515
             ++   K   R K+ ++  +E        E
Sbjct: 385 DDKKSSVKSGSREKQSEDTNTESKESDTKNE 415



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 18/62 (29%), Positives = 33/62 (53%), Gaps = 3/62 (4%)

Query: 372 DTSKQWDYYARREKDRDRERDRD--RERDRDRDRERER-TRERERERDHSPTPSVFNSDE 428
           D S++      R++ R + RDR   + R + RDRE++R ++E+E+        SV +   
Sbjct: 337 DRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSR 396

Query: 429 ER 430
           E+
Sbjct: 397 EK 398


>gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo
           sapiens]
          Length = 820

 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 43/133 (32%), Positives = 68/133 (51%), Gaps = 11/133 (8%)

Query: 383 REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYE 442
           R  DR+R+RDRDR+    +DR+R R+R+R R    S + S   S E   R++E  ER  E
Sbjct: 24  RTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERERRHKE-RERDKE 82

Query: 443 RHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKE 502
           R    R K++R R++    +++ R +SS S  R       G   +  K + SK+ +E + 
Sbjct: 83  R---DRNKKDRDRDKDGHRRDKDRKRSSLSPGR-------GKDFKSRKDRDSKKDEEDEH 132

Query: 503 AGSEPAPEQESTE 515
              +P  +  S E
Sbjct: 133 GDKKPKAQPLSLE 145



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 45/143 (31%), Positives = 66/143 (46%), Gaps = 21/143 (14%)

Query: 384 EKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYER 443
           +KDRD    ++     +R R R   RER+R+RD   +PS    D +R+R R+   RG  R
Sbjct: 8   KKDRDASPSKE-----ERKRSRTPDRERDRDRDRKSSPS---KDRKRHRSRD-RRRGGSR 58

Query: 444 HRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKK--------SK 495
            R+    +   RERRH+E+E  + +      R R    + D HRR K +K         K
Sbjct: 59  SRSRSRSKSAERERRHKERERDKERDRNKKDRDR----DKDGHRRDKDRKRSSLSPGRGK 114

Query: 496 RSKEGKEAGSEPAPEQESTEATP 518
             K  K+  S+   E E  +  P
Sbjct: 115 DFKSRKDRDSKKDEEDEHGDKKP 137



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 41/144 (28%), Positives = 61/144 (42%), Gaps = 13/144 (9%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDR--DRDRERERTRERERERDHSPTPSVFNSDEE 429
           D  +  D   +    +DR+R R R+R R   R R R R++  ERER H         D+E
Sbjct: 27  DRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERERRHKER----ERDKE 82

Query: 430 RYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRH 489
           R R ++  +R  + HR       R ++R+       R K  +S   R  + +E D H   
Sbjct: 83  RDRNKKDRDRDKDGHR-------RDKDRKRSSLSPGRGKDFKSRKDRDSKKDEEDEHGDK 135

Query: 490 KHKKSKRSKEGKEAGSEPAPEQES 513
           K K    S E   A  +   E E+
Sbjct: 136 KPKAQPLSLEELLAKKKAEEEAEA 159



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 39/155 (25%), Positives = 66/155 (42%), Gaps = 35/155 (22%)

Query: 383 REKDRDRERDR---DRERDRD---RDRERERT-------------RERERERDHSPT--- 420
           +E++RD+ERDR   DR+RD+D   RD++R+R+             ++R+ ++D       
Sbjct: 75  KERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSKKDEEDEHGD 134

Query: 421 --PSVFNSDEERYRYREYAERGYERHRASREKEERHRE---RRHREKEETRHKSSRSNSR 475
             P       E    ++ AE   E       K ER  E   RR +E EE +        +
Sbjct: 135 KKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKK 194

Query: 476 RRHESEEG--------DSHRRHKHKKSKRSKEGKE 502
           R+   + G        +  RR + ++ +R   G E
Sbjct: 195 RKQFQDLGRKMLEDPQERERRERRERMERETNGNE 229



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 28/101 (27%), Positives = 45/101 (44%), Gaps = 16/101 (15%)

Query: 402 DRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHRE 461
           +RE E  + R++E +          +EER + +++ + G +     +E+E R  ERR R 
Sbjct: 168 EREAEALKRRQQEVEERQRML----EEERKKRKQFQDLGRKMLEDPQERERR--ERRERM 221

Query: 462 KEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKE 502
           + ET            +E EEG    R +  KSK     KE
Sbjct: 222 ERET----------NGNEDEEGRQKIREEKDKSKELHAIKE 252


>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo
           sapiens]
          Length = 1758

 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 68/251 (27%), Positives = 93/251 (37%), Gaps = 37/251 (14%)

Query: 268 SERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPP--PPGA 325
           SERS      +    P F P       +PPPP  PPPP     PP +PPP F P  PPG 
Sbjct: 539 SERSQRTQGPSLPATPVFVP-------VPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQ 591

Query: 326 PPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPG--SAPSWPSLVDTSKQWDYYARR 383
           PPP           +GY        P G   FP  P   S P   S V T+        +
Sbjct: 592 PPP-----------AGYS-----VPPPG---FPPAPANLSTPWVSSGVQTAHSNTIPTTQ 632

Query: 384 EKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFN-SDEERYRYREYAERGYE 442
                RE     E  R++ R +E ++       +S +   ++ S     R R Y+ R + 
Sbjct: 633 APPLSRE-----EFYREQRRLKEESKSPYSGSSYSRSSYTYSKSRSGSTRSRSYS-RSFS 686

Query: 443 RHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKE 502
           R  +          RR R K       SRS+   R  S      R H   +S ++  G+ 
Sbjct: 687 RSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQS 746

Query: 503 AGSEPAPEQES 513
                 P+ E+
Sbjct: 747 PNKRNVPQGET 757



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 25/105 (23%), Positives = 53/105 (50%), Gaps = 5/105 (4%)

Query: 413  RERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEE-TRHKSSR 471
            R + HS +PSV  S    +       R +    +S E ++  ++++ +EK++  +HK  +
Sbjct: 1655 RNQSHS-SPSV--SPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHK 1711

Query: 472  SNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEA 516
             + +      E +  ++HKHKK K+SK+ K+   E   + +  ++
Sbjct: 1712 KHKKHAGTEVELEKSQKHKHKK-KKSKKNKDKEKEKEKDDQKVKS 1755



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 42/161 (26%), Positives = 65/161 (40%), Gaps = 28/161 (17%)

Query: 379 YYARREKDRDR-ERDRDRERDRDRDRERER----------TRERERERDHSPTP----SV 423
           YY R    RD  E++R RE +R      E+           R      + SP      ++
Sbjct: 777 YYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNI 836

Query: 424 FNSDEERYRYREYAERGYERHRA----SREKEERHRERRHREKEETRHKSSRSNSRRRHE 479
            NS   R R  +Y   G + HR+    S   E+      H +K+ T+ K   S      E
Sbjct: 837 RNSPFTRGRREDYV--GGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKES------E 888

Query: 480 SEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE 520
           +  GD  + +KHKK ++ ++G+E+     PE   T     E
Sbjct: 889 NAPGDG-KGNKHKKHRKRRKGEESEGFLNPELLETSRKSRE 928



 Score = 33.5 bits (75), Expect = 0.48
 Identities = 22/95 (23%), Positives = 44/95 (46%), Gaps = 21/95 (22%)

Query: 405  RERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEE 464
            R  +    + R HS + S   S +                  S++K+++  +++H  K+ 
Sbjct: 1668 RSHSPSGSQTRSHSSSASSAESQD------------------SKKKKKKKEKKKH--KKH 1707

Query: 465  TRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKE 499
             +HK  + ++    E E+   H +HK KKSK++K+
Sbjct: 1708 KKHKKHKKHAGTEVELEKSQKH-KHKKKKSKKNKD 1741



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 29/154 (18%), Positives = 64/154 (41%), Gaps = 7/154 (4%)

Query: 373  TSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYR 432
            T ++ D  A  +K+   +  +  +   D +RER    E   ++    TP   N+      
Sbjct: 985  TKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSS 1044

Query: 433  YREYAERGYERHRASREKEERHRERRHREKEETRH------KSSRSNSRRRHESEEGDSH 486
             ++    G  R   S+  +E H+E +  ++E+ +       KS +  ++     +  + +
Sbjct: 1045 QKDEKITGTPRKAHSKSAKE-HQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKN 1103

Query: 487  RRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE 520
            +   +K  KR ++ +E G +   E  S + +  E
Sbjct: 1104 KPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLE 1137


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 60/267 (22%), Positives = 110/267 (41%), Gaps = 29/267 (10%)

Query: 258 ANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL----PPPPTVSTAPPL 313
           +N  S+ Q+ ++ S  +V   + K P F       +HLPPPP L     PPP     P  
Sbjct: 371 SNTKSSSQIPAQPSVAKVP--YGKGPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGR 428

Query: 314 IPPPGFPPPPGAPPPSLIPTIESGHSSGYDS-----RSARAFPYGNVAFPHLPGSAPSWP 368
             P  FP          I        S   +     R  R      +        A    
Sbjct: 429 --PGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLK 486

Query: 369 SLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDE 428
            L +     +     E+ R+RER+++RER+++ ++E+E+ RE+ERE+           D 
Sbjct: 487 RLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREK-----------DR 535

Query: 429 ERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRR 488
           ER +     E+  E  +   ++ E  +ER+  +++E   +  +    ++ + +E +    
Sbjct: 536 ERQQ-----EKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELE 590

Query: 489 HKHKKSKRSKEGKEAGSEPAPEQESTE 515
            + +K +   E +E   EP  E++ +E
Sbjct: 591 KEREKLEEKIEPREPNLEPMVEKQESE 617



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 35/141 (24%), Positives = 67/141 (47%), Gaps = 4/141 (2%)

Query: 372 DTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERY 431
           +  K+ +    +E+++DRER +++E++ ++++E++R  E+ER+++           E+  
Sbjct: 518 ELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKEL 577

Query: 432 RYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHES---EEGDSHRR 488
           +  +  E+  E  +  REK E   E R    E    K    NS  + E       DS+R 
Sbjct: 578 QKMKEQEKECELEK-EREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRS 636

Query: 489 HKHKKSKRSKEGKEAGSEPAP 509
            K       +   E+GS+P P
Sbjct: 637 EKEATPVVHETEPESGSQPRP 657



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 61/248 (24%), Positives = 84/248 (33%), Gaps = 45/248 (18%)

Query: 301  LPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHL 360
            LPPPP     P  I P   PPP   P     P+ E+   +   S+            P  
Sbjct: 1058 LPPPPPPPQPPAPIQPQSVPPPI-QPEAEKFPSTETATLAQKPSQDTEK--------PLE 1108

Query: 361  PGSAPSWPSLVDTSKQWDYYA---RREKDRDRERDRDRERDRDRDRERERTRERE----- 412
            P S       V T  Q    A   + EK  ++   +D   +R R   R   ++       
Sbjct: 1109 PVSTVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISKDLVIERPRPDSRPAVKKESTLPPR 1168

Query: 413  ------RERDHSPTPSVFNSDEERYRYREYAERG---------------YERHRASREKE 451
                  RERD  P           Y  R  + RG               Y ++R ++ + 
Sbjct: 1169 TYWKEARERDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGRGGRGHTRDYPQYRDNKPRA 1228

Query: 452  ER--HRERRHREKEETRHKSSRSN---SRRRHESEEGDSHRR-HKHKKSKRS-KEGKEAG 504
            E       R RE+ ETR +SS       RRR    E D+    H+    K S  +GK   
Sbjct: 1229 EHIPSGPLRQREESETRSESSDFEVVPKRRRQRGSETDTDSEIHESASDKDSLSKGKLPK 1288

Query: 505  SEPAPEQE 512
             E  PE +
Sbjct: 1289 REERPENK 1296


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.130    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,253,362
Number of Sequences: 37866
Number of extensions: 1949502
Number of successful extensions: 57999
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1104
Number of HSP's successfully gapped in prelim test: 1283
Number of HSP's that attempted gapping in prelim test: 16329
Number of HSP's gapped (non-prelim): 19160
length of query: 520
length of database: 18,247,518
effective HSP length: 107
effective length of query: 413
effective length of database: 14,195,856
effective search space: 5862888528
effective search space used: 5862888528
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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