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Search of human proteins with 20070188
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20070188 solute carrier family 22 member 6 isoform a [Homo
sapiens]
(563 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa... 1130 0.0
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa... 1092 0.0
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa... 1026 0.0
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa... 988 0.0
gi|24497499 solute carrier family 22 member 8 [Homo sapiens] 538 e-153
gi|238814326 solute carrier family 22, member 20 [Homo sapiens] 501 e-142
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens] 473 e-133
gi|8923870 solute carrier family 22 member 11 [Homo sapiens] 435 e-122
gi|148664184 solute carrier family 22, member 10 [Homo sapiens] 417 e-116
gi|211059435 solute carrier family 22, member 24 [Homo sapiens] 408 e-114
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa... 382 e-106
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa... 377 e-104
gi|153791484 putative UST1-like organic anion transporter [Homo ... 369 e-102
gi|42542386 solute carrier family 22 (organic anion/cation trans... 358 6e-99
gi|166064021 solute carrier family 22 (organic anion transporter... 337 1e-92
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens] 283 3e-76
gi|11415038 solute carrier family 22 member 3 [Homo sapiens] 277 2e-74
gi|4507001 solute carrier family 22 member 2 [Homo sapiens] 261 2e-69
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap... 255 9e-68
gi|4507005 solute carrier family 22 member 5 [Homo sapiens] 238 1e-62
gi|31542327 solute carrier family 22, member 16 [Homo sapiens] 223 4e-58
gi|157426885 organic cation transporter like 4 [Homo sapiens] 221 1e-57
gi|24497490 solute carrier family 22 member 4 [Homo sapiens] 219 4e-57
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa... 209 4e-54
gi|166197673 solute carrier family 22, member 15 [Homo sapiens] 208 1e-53
gi|170650643 solute carrier family 22, member 23 isoform a [Homo... 130 3e-30
gi|24308167 SV2 related protein [Homo sapiens] 129 7e-30
gi|213021148 SVOP-like isoform 1 [Homo sapiens] 128 2e-29
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ... 123 5e-28
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1... 122 7e-28
>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
sapiens]
Length = 563
Score = 1130 bits (2924), Expect = 0.0
Identities = 563/563 (100%), Positives = 563/563 (100%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
Sbjct: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60
Query: 61 GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI 120
GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI
Sbjct: 61 GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI 120
Query: 121 VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA 180
VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA
Sbjct: 121 VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA 180
Query: 181 FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV 240
FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
Sbjct: 181 FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV 240
Query: 241 AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE 300
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE
Sbjct: 241 AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE 300
Query: 301 GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL 360
GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL
Sbjct: 301 GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL 360
Query: 361 QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS 420
QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS
Sbjct: 361 QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS 420
Query: 421 IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE 480
IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
Sbjct: 421 IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE 480
Query: 481 LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT 540
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT
Sbjct: 481 LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT 540
Query: 541 RQQQEHQKYMVPLQASAQEKNGL 563
RQQQEHQKYMVPLQASAQEKNGL
Sbjct: 541 RQQQEHQKYMVPLQASAQEKNGL 563
>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
sapiens]
Length = 550
Score = 1092 bits (2825), Expect = 0.0
Identities = 550/563 (97%), Positives = 550/563 (97%), Gaps = 13/563 (2%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
Sbjct: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60
Query: 61 GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI 120
GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI
Sbjct: 61 GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI 120
Query: 121 VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA 180
VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA
Sbjct: 121 VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA 180
Query: 181 FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV 240
FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
Sbjct: 181 FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV 240
Query: 241 AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE 300
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE
Sbjct: 241 AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE 300
Query: 301 GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL 360
GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL
Sbjct: 301 GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL 360
Query: 361 QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS 420
QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS
Sbjct: 361 QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS 420
Query: 421 IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE 480
IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
Sbjct: 421 IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE 480
Query: 481 LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT 540
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES RKGKQT
Sbjct: 481 LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES-------------RKGKQT 527
Query: 541 RQQQEHQKYMVPLQASAQEKNGL 563
RQQQEHQKYMVPLQASAQEKNGL
Sbjct: 528 RQQQEHQKYMVPLQASAQEKNGL 550
>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
sapiens]
Length = 519
Score = 1026 bits (2652), Expect = 0.0
Identities = 519/563 (92%), Positives = 519/563 (92%), Gaps = 44/563 (7%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
Sbjct: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60
Query: 61 GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI 120
GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI
Sbjct: 61 GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI 120
Query: 121 VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA 180
VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA
Sbjct: 121 VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA 180
Query: 181 FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV 240
FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
Sbjct: 181 FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV 240
Query: 241 AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE 300
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE
Sbjct: 241 AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE 300
Query: 301 GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL 360
GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL
Sbjct: 301 GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL 360
Query: 361 QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS 420
QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS
Sbjct: 361 QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS 420
Query: 421 IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE 480
IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR
Sbjct: 421 IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR-------------------------- 454
Query: 481 LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT 540
AVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT
Sbjct: 455 ------------------AVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT 496
Query: 541 RQQQEHQKYMVPLQASAQEKNGL 563
RQQQEHQKYMVPLQASAQEKNGL
Sbjct: 497 RQQQEHQKYMVPLQASAQEKNGL 519
>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
sapiens]
Length = 506
Score = 988 bits (2553), Expect = 0.0
Identities = 506/563 (89%), Positives = 506/563 (89%), Gaps = 57/563 (10%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
Sbjct: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60
Query: 61 GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI 120
GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI
Sbjct: 61 GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI 120
Query: 121 VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA 180
VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA
Sbjct: 121 VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA 180
Query: 181 FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV 240
FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
Sbjct: 181 FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV 240
Query: 241 AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE 300
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE
Sbjct: 241 AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE 300
Query: 301 GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL 360
GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL
Sbjct: 301 GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL 360
Query: 361 QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS 420
QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS
Sbjct: 361 QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS 420
Query: 421 IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE 480
IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR
Sbjct: 421 IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR-------------------------- 454
Query: 481 LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT 540
AVTVLLPETLGQPLPDTVQDLES RKGKQT
Sbjct: 455 ------------------AVTVLLPETLGQPLPDTVQDLES-------------RKGKQT 483
Query: 541 RQQQEHQKYMVPLQASAQEKNGL 563
RQQQEHQKYMVPLQASAQEKNGL
Sbjct: 484 RQQQEHQKYMVPLQASAQEKNGL 506
>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
Length = 542
Score = 538 bits (1387), Expect = e-153
Identities = 277/558 (49%), Positives = 373/558 (66%), Gaps = 29/558 (5%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60
M F+++L +VG +G FQ + V ++ LP+L MA+HN LQ FTAA P HHCRPP +A+
Sbjct: 1 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP- 59
Query: 61 GGLEVW-LPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTG-ATEPCTDGWIYDNSTFPS 118
W LP G+PE CLRF P N + N T A EPC DGW+Y NST S
Sbjct: 60 -----WVLPMGPNGKPERCLRFVHPP------NASLPNDTQRAMEPCLDGWVY-NSTKDS 107
Query: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178
IVTEWDLVC+ L+++AQS++M G+L+G +V G L+DR GRR +L +YL A SG+
Sbjct: 108 -IVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSG 166
Query: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238
AAF+P FPIY FR L G ++GI+L+ + LNVEW+P RA + T +GY Y+ GQF+L
Sbjct: 167 AAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILP 226
Query: 239 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR 298
G+AYA+P WR LQL VS PFF FF+ SW+ ES RW SG+ L+ L+RVA NGK+
Sbjct: 227 GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK 286
Query: 299 EEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM 358
EEG +LS+E L+ +LQKE+++ K + +A +L R P LR + CLS+ WFAT FAYY L M
Sbjct: 287 EEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAM 346
Query: 359 DLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQD 418
++ FGV++Y++Q+IFG VD+PAK + L ++ LGR Q AALLLAG IL +P D
Sbjct: 347 GVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLD 406
Query: 419 QSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMT 478
VRT LAV GKGCL++SF+C+FLYT ELYPT+IRQTGMG+ + RVGS+VSPLV +T
Sbjct: 407 LQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKIT 466
Query: 479 AELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGK 538
E+ P +P IYG + + + LPETL QPLP+T++DLE+ + + K
Sbjct: 467 GEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLEN-----------WSLRAK 515
Query: 539 QTRQQQEHQK--YMVPLQ 554
+ +Q+ E +K +PLQ
Sbjct: 516 KPKQEPEVEKASQRIPLQ 533
>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
Length = 555
Score = 501 bits (1290), Expect = e-142
Identities = 252/526 (47%), Positives = 335/526 (63%), Gaps = 6/526 (1%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60
MAF DLL +G +GRFQ L++LP L+A HN LQNFTAA+P HHCR PA+ +
Sbjct: 1 MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST 60
Query: 61 GGLEVWL----PRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTF 116
WL P D+ G PE C RFT PQW L L+ + ATE C DGW+Y+ S F
Sbjct: 61 NDSGAWLRATIPLDQLGAPEPCRRFTKPQWAL--LSPNSSIPGAATEGCKDGWVYNRSVF 118
Query: 117 PSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSG 176
PSTIV EWDLVC R LR LAQS+YM GVL+GA VFG LADRLG + L+ +YLQ A SG
Sbjct: 119 PSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASG 178
Query: 177 TCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFL 236
A+ +F YC FR L GM +GI LN ++L VEWMP R G L+GY ++LGQ +
Sbjct: 179 AATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLI 238
Query: 237 LAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARING 296
LAGVAY + WR LQ +SAPF FF+YSW+ ES+RW G+ L ++ LQ+VA +NG
Sbjct: 239 LAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNG 298
Query: 297 KREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGL 356
++EEG +L+ EV+ + +Q E S ++L R P +R + CL ++WF+ S AYYGL
Sbjct: 299 RKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGL 358
Query: 357 VMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIP 416
MDLQ FG+S+YL+Q +FG ++ PA LV + +GRR + L+LAG+ ++ N +P
Sbjct: 359 AMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVP 418
Query: 417 QDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVS 476
+ I+ T+ A LGKGCLA+SF C++L+TGELYPT IRQ GMG S AR+G + +PLV+
Sbjct: 419 EGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLVT 478
Query: 477 MTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESR 522
E +P +GA + A +L ET PL +T+ +E R
Sbjct: 479 TLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERR 524
>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
Length = 553
Score = 473 bits (1218), Expect = e-133
Identities = 244/533 (45%), Positives = 339/533 (63%), Gaps = 11/533 (2%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56
MAF++LL VGG+GRFQ +Q +++ ++ + + + L+NF+AA+P+H C P N
Sbjct: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
Query: 57 ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109
LS L + +P +P C RF PQW L N T + + A TEPC DGW
Sbjct: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
Query: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
+YD S F STIV +W+LVC AL+ +AQS+Y+ G+L+GA G +DR GRR VL +Y
Sbjct: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
Query: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
LQ AV GT AAFAP FP+YC FR L A+AG+ +N TL +EW R V TL
Sbjct: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
Query: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289
+S G L A VAY V W LQL+VS PFF F+YSW+ ESARW ++GRLD L+ L
Sbjct: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
Query: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349
RVA INGK L+ EVL +++++EL+MG+ AS LLR P LR ++ WFA
Sbjct: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
Query: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409
F ++GL +DLQ G +I+L+Q+ G VD+PAK+ L+++ LGRRP A+LLLAG+CI
Sbjct: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420
Query: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469
L N ++P + +R++LAVLG G + A+F CI +Y+ EL+PT++R T +G+G AR G+
Sbjct: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480
Query: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESR 522
I+ PLV + P +PL +YG VPV + +LLPET PLPDT+QD++++
Sbjct: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQ 533
>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
Length = 550
Score = 435 bits (1118), Expect = e-122
Identities = 228/531 (42%), Positives = 324/531 (61%), Gaps = 10/531 (1%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHC-------RPPA 53
MAF+ LL+Q GGVG FQ +QV +LP L++ S L+NF+AAIP H C
Sbjct: 1 MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAV 60
Query: 54 DANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGWIYD 112
N++ L + +P P C RF PQW L N T + + A TEPC DGW+YD
Sbjct: 61 STNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYD 120
Query: 113 NSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQT 172
S F STIV +WDLVCS + L+ L+QS++M G+L+G+ ++G L+ R GR+ +L LQ
Sbjct: 121 RSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQL 180
Query: 173 AVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSL 232
AV+GT FAP F IYC R ++ +AGI L+ +TL VEW RA T++G +S
Sbjct: 181 AVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSA 240
Query: 233 GQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVA 292
GQ L G+A+A+ WR LQL S PFFA + SW+ ESARW G+ D L+ L++VA
Sbjct: 241 GQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVA 300
Query: 293 RINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFA 352
RING +E L++EVL +S+++E+ K S ++L P LR + ++ F+ +
Sbjct: 301 RING-HKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLIS 359
Query: 353 YYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLN 412
YYGLV DLQ G I+L+Q +FGAVD + L+++ LGRR Q + +AG+ IL N
Sbjct: 360 YYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILAN 419
Query: 413 GVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVS 472
++PQD +R AVLGKGC S C+ +Y EL+PT +R T G+ T+ R+G+++
Sbjct: 420 MLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMG 479
Query: 473 PLVSMTAELYPSMPLFIYGAVPVAASAVTV-LLPETLGQPLPDTVQDLESR 522
PL+ M+ + P +P +YG + +A+S V + LPET G PLPDT+QDLES+
Sbjct: 480 PLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQ 530
>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
Length = 541
Score = 417 bits (1071), Expect = e-116
Identities = 212/533 (39%), Positives = 327/533 (61%), Gaps = 11/533 (2%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56
MAF +LL QVGG+GRFQ + + ++ L+L+ H L+NF AAIP H C N
Sbjct: 1 MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
Query: 57 ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGT-EANGTGATEPCTDGW 109
LS++ L + +P D +PE C RF PQW L LNGT + TEPC DGW
Sbjct: 61 GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
Query: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
+YD S FPSTIVT+WDLVC +++L+ + Q L + G+L+G ++ G+++DR GRR +L
Sbjct: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180
Query: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
LQ A++ TCAAFAP FP+YC R L+G + I N EW+ +++A V L
Sbjct: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240
Query: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289
S+GQ +L G+AY W+ L ++ S PFF FF+ S + +ESARW + +LD L+AL+
Sbjct: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300
Query: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349
+VAR NG + L++EV+R+++Q+EL + + + +L R P++R L L FA
Sbjct: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360
Query: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409
+ +YG +++LQ G +I+L+QV++GAV L + + L +N +GRR +Q+ + L G+ I
Sbjct: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420
Query: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469
L N +P++ +R +LA LG GC AA+F+ + ++ EL PT++R G+ T +R+G+
Sbjct: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480
Query: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESR 522
++PL+ + ++P IYG P+ + LLPET PLPDT++D+E++
Sbjct: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQ 533
>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
Length = 551
Score = 408 bits (1049), Expect = e-114
Identities = 217/532 (40%), Positives = 317/532 (59%), Gaps = 11/532 (2%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56
M F+ LL QVGG+GRFQ + + +L+ + L+NFTA P+H C P N
Sbjct: 1 MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
Query: 57 ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109
LSK+ L + +P D +P+ C RF PQW L LNGT N TEPC DGW
Sbjct: 61 DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
Query: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
+YD S+F STIVTEWDLVC ++L+ + QSL+M G LLG +++G+L+DR+GR+ + L +
Sbjct: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
Query: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
LQ A+S TCAAFAP F +YC R L+G + I N L++EW +R+ ++
Sbjct: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
Query: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289
YS+GQ LL G+A+A+ W LQL VS P F+ SW +ESARW + +LD L+ L+
Sbjct: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
Query: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349
RVA INGK+ L+ E++R++++KEL + + S L R P LR L + FA
Sbjct: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360
Query: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409
+ +YGL+++LQ G ++ L Q++ GAV A+ V L +N +GRR +Q+ G+ I
Sbjct: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420
Query: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469
L+N +PQ+ I+R LA LG G ++A+ N ++ EL PT++R T G+ + R G+
Sbjct: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480
Query: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES 521
++PL+ P +P YG P+ A V +LLPET PLP+T+QD+E+
Sbjct: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVEN 532
>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
sapiens]
Length = 546
Score = 382 bits (982), Expect = e-106
Identities = 215/548 (39%), Positives = 311/548 (56%), Gaps = 12/548 (2%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR-PPADANLS- 58
M F +LL+QVGG G FQ V L+ LP +L+ H L F AA+P H C P A AN S
Sbjct: 1 MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
Query: 59 KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLN-GTEANGTG------ATEPCTDGWIY 111
++ LE LPR+ G SCLRF PQ LP G E G AT PC+ GW Y
Sbjct: 61 QDVWLEAHLPREPDGTLSSCLRFAYPQ-ALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119
Query: 112 DNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQ 171
D+S F STI TEWDLVC + L + A + + GVL+GA+ FGYL+DR GRR++L++ Y+
Sbjct: 120 DHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVS 179
Query: 172 TAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYS 231
T V G +A + ++ ++ R L+G ALAG ++ M L +EW+ + R G L ++
Sbjct: 180 TLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWT 239
Query: 232 LGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRV 291
G LLA V Y + WR L L V+ P + W+ ESARW + G + R L
Sbjct: 240 GGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHC 299
Query: 292 ARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSF 351
AR+NG+ S E + E + + S ++L R P LRH+ LC ++WF +F
Sbjct: 300 ARLNGRPVCEDSFSQEAVSKVAAGERVVRR--PSYLDLFRTPRLRHISLCCVVVWFGVNF 357
Query: 352 AYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL 411
+YYGL +D+ G G+++Y Q++FGAV+LP+KL+ +L + GRR Q LL +
Sbjct: 358 SYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGT 417
Query: 412 NGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIV 471
++ D T LAV+GK A+F +L+T ELYPT++RQTGMG+ + + R+G +
Sbjct: 418 RLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSL 477
Query: 472 SPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAG 531
+PL ++ ++ S+P YG + + A+ +LLPET LP+T+QD+E + APT +
Sbjct: 478 APLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEE 537
Query: 532 IYPRKGKQ 539
P K Q
Sbjct: 538 EMPMKQVQ 545
>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
sapiens]
Length = 548
Score = 377 bits (969), Expect = e-104
Identities = 215/550 (39%), Positives = 311/550 (56%), Gaps = 14/550 (2%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR-PPADANLS- 58
M F +LL+QVGG G FQ V L+ LP +L+ H L F AA+P H C P A AN S
Sbjct: 1 MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
Query: 59 KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLN-GTEANGTG------ATEPCTDGWIY 111
++ LE LPR+ G SCLRF PQ LP G E G AT PC+ GW Y
Sbjct: 61 QDVWLEAHLPREPDGTLSSCLRFAYPQ-ALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119
Query: 112 DNSTFPSTIVTE--WDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
D+S F STI TE WDLVC + L + A + + GVL+GA+ FGYL+DR GRR++L++ Y
Sbjct: 120 DHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAY 179
Query: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
+ T V G +A + ++ ++ R L+G ALAG ++ M L +EW+ + R G L
Sbjct: 180 VSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTF 239
Query: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289
++ G LLA V Y + WR L L V+ P + W+ ESARW + G + R L
Sbjct: 240 WTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLL 299
Query: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349
AR+NG+ S E + E + + S ++L R P LRH+ LC ++WF
Sbjct: 300 HCARLNGRPVCEDSFSQEAVSKVAAGERVVRR--PSYLDLFRTPRLRHISLCCVVVWFGV 357
Query: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409
+F+YYGL +D+ G G+++Y Q++FGAV+LP+KL+ +L + GRR Q LL +
Sbjct: 358 NFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAF 417
Query: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469
++ D T LAV+GK A+F +L+T ELYPT++RQTGMG+ + + R+G
Sbjct: 418 GTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGG 477
Query: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKE 529
++PL ++ ++ S+P YG + + A+ +LLPET LP+T+QD+E + APT +
Sbjct: 478 SLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQ 537
Query: 530 AGIYPRKGKQ 539
P K Q
Sbjct: 538 EEEMPMKQVQ 547
>gi|153791484 putative UST1-like organic anion transporter [Homo
sapiens]
Length = 547
Score = 369 bits (947), Expect = e-102
Identities = 204/532 (38%), Positives = 306/532 (57%), Gaps = 11/532 (2%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR---------P 51
MAF DLL QVGG+GRFQ +Q+ +++ +++ L+NF A I H C P
Sbjct: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
Query: 52 PAD-ANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109
D LS++ L + +P D +PE C RF PQW L LNGT N + TEPC DGW
Sbjct: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
Query: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
+YD S+FPSTIVT+WDLVC + L +A+ L+M G+++G ++G+L+DR GR+ VL +Y
Sbjct: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
Query: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
LQ A+ GTCAAFAP +YC+ R L+G A I +N + L VEW+ A TL
Sbjct: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
Query: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289
S+G L +A+ + LQL++SAP F FF++S + ESARW + + + L+ L+
Sbjct: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
Query: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349
+ A NG + L+MEVL++++++EL + + S ELLR P + LS + FA+
Sbjct: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
Query: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409
+ ++GL + LQ G +++L+Q +FGAV L A V +N + RR +QM + L C+
Sbjct: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
Query: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469
L +PQ+ +R LA LG G + C EL P++IR G+ A +G
Sbjct: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
Query: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES 521
++ L+ + + +P IYG + + V +LLPET QPL D++QD+E+
Sbjct: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVEN 532
>gi|42542386 solute carrier family 22 (organic anion/cation
transporter), member 9 [Homo sapiens]
Length = 553
Score = 358 bits (920), Expect = 6e-99
Identities = 205/531 (38%), Positives = 300/531 (56%), Gaps = 14/531 (2%)
Query: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56
MAF DLL G + RFQ +Q + + + H L+NFTA IP H C N
Sbjct: 1 MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
Query: 57 ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGAT-EPCTDGW 109
LS++ L + +P D +PE C RF PQW L LNGT N + A EPC DGW
Sbjct: 61 DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
Query: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
+YD +F STIVTEWDLVC ++L +A+ ++M G+++G ++ G+L+DR GRR VL Y
Sbjct: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
Query: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
LQ A+ GTCAA AP F IYC+ R LSG+A + N + L EW H +G +G
Sbjct: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEW-ATHRFQAMGITLGMC 239
Query: 230 YSLGQFL-LAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRAL 288
S F+ LAG+A+A+ W LQL+VS P+F F+ S + +ESARW + + + L+ L
Sbjct: 240 PSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299
Query: 289 QRVARINGKREEGAKLSMEVLRASLQKELTMG-KGQASAMELLRCPTLRHLFLCLSMLWF 347
++ A +G + L++E+L+++++KEL K + S E+L P + LS F
Sbjct: 300 RKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRF 359
Query: 348 ATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGI 407
A AY+GL + +Q G +++L+Q +FGAV L A V + + RR +QM + L I
Sbjct: 360 ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAI 419
Query: 408 CILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARV 467
C+L +PQ+ +R LA LG G A + F + E+ PT+IR MG+ +T A +
Sbjct: 420 CLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANI 479
Query: 468 GSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQD 518
++PL+ + + P +P IYG P + +LLPET +PL DT+QD
Sbjct: 480 AGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQD 530
>gi|166064021 solute carrier family 22 (organic anion transporter),
member 13 [Homo sapiens]
Length = 551
Score = 337 bits (865), Expect = 1e-92
Identities = 200/548 (36%), Positives = 301/548 (54%), Gaps = 25/548 (4%)
Query: 3 FNDLLQQVGGVGRFQ-QIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPP----ADANL 57
F +L ++G GRFQ Q+ + L VL L + F HHC NL
Sbjct: 4 FVQVLAEIGDFGRFQIQLLILLCVLNFL-SPFYFFAHVFMVLDEPHHCAVAWVKNHTFNL 62
Query: 58 SKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFP 117
S L + +P D G PE CL F P L ++ T+PC GW Y + P
Sbjct: 63 SAAEQLVLSVPLDTAGHPEPCLMFRPPPANAS-LQDILSHRFNETQPCDMGWEYPENRLP 121
Query: 118 STIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGT 177
S + E++LVC + L+ QS++M G+L+G ++FG L DR+GR+ ++ L + G
Sbjct: 122 S-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGL 180
Query: 178 CAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLL 237
AF P+F +Y A R A+AG+S + +TL EW+ R L +SLGQ +L
Sbjct: 181 ATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVL 240
Query: 238 AGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGK 297
AG+AY +WR LQ+ +AP F Y W ESARW + GR+D ++ +Q+ A +N +
Sbjct: 241 AGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRR 300
Query: 298 REEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLV 357
KLS E++ L E T G +A++L R P LR + L + +WF S YYGL
Sbjct: 301 -----KLSPELMN-QLVPEKTGPSG--NALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLS 352
Query: 358 MDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQ 417
+ + FG+ +YL Q+IFGAV++PA+ ++ GR+ +Q+ L+L G+ ++ IP
Sbjct: 353 LQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPA 412
Query: 418 DQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSM 477
D +V T LAV+GK AA+F ++Y+ EL+PT++RQTGMG+ +R+G I++PLV +
Sbjct: 413 DLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVIL 472
Query: 478 TAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKG 537
E + ++P+ IYG++P+ A + LLPET GQ L DT+QDL E G +PR
Sbjct: 473 LGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDL---------ELGPHPRSP 523
Query: 538 KQTRQQQE 545
K ++E
Sbjct: 524 KSVPSEKE 531
>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
Length = 332
Score = 283 bits (724), Expect = 3e-76
Identities = 144/312 (46%), Positives = 203/312 (65%)
Query: 211 VEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIE 270
+EW R V TL +S G L A VAY V W LQL+VS PFF F+YSW+ E
Sbjct: 1 MEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAE 60
Query: 271 SARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELL 330
SARW ++GRLD L+ L RVA INGK L+ EVL +++++EL+MG+ AS LL
Sbjct: 61 SARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLL 120
Query: 331 RCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVIN 390
R P LR ++ WFA F ++GL +DLQ G +I+L+Q+ G VD+PAK+ L+++
Sbjct: 121 RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLS 180
Query: 391 SLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYP 450
LGRRP A+LLLAG+CIL N ++P + +R++LAVLG G + A+F CI +Y+ EL+P
Sbjct: 181 HLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFP 240
Query: 451 TMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQ 510
T++R T +G+G AR G+I+ PLV + P +PL +YG VPV + +LLPET
Sbjct: 241 TVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSL 300
Query: 511 PLPDTVQDLESR 522
PLPDT+QD++++
Sbjct: 301 PLPDTIQDVQNQ 312
>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
Length = 556
Score = 277 bits (709), Expect = 2e-74
Identities = 186/567 (32%), Positives = 287/567 (50%), Gaps = 36/567 (6%)
Query: 2 AFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHH-CRPPADANLSKN 60
+F++ LQ+VG GRFQ+ L+ L + A F P H+ CR P+ A L++
Sbjct: 3 SFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAER 62
Query: 61 GGL---EVW---LPRDRQGQPES----CLRF--------TSPQWGLPFLNGTEA--NGTG 100
G E W P R +P C R+ S L + A N +
Sbjct: 63 CGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSA 122
Query: 101 ATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLG 160
PC GW Y + STIV+E+DLVC + + L Q++ +G L GA GY ADR G
Sbjct: 123 PLVPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYG 180
Query: 161 RRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRA 220
R + +L+ L V+G AFAPNFP++ FR L G+ G + C + E + R
Sbjct: 181 RIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRR 240
Query: 221 CVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGR 280
VG +I ++LG +L G+AY +P+W+ +QL ++ P F F +Y W ES RW + +
Sbjct: 241 IVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKK 300
Query: 281 LDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFL 340
D L+ L+R+A+ NGK LS ++ E S ++L+R P +R L
Sbjct: 301 GDKALQILRRIAKCNGK-----YLSSNYSEITVTDEEV---SNPSFLDLVRTPQMRKCTL 352
Query: 341 CLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMA 400
L WF ++ Y GLVM L G ++Y+ I G V+LP L+ L I LGRR A
Sbjct: 353 ILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAA 412
Query: 401 ALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGM 460
+ ++AG+ L+ +P+ + +RT++A LG+ + +F ++L ELYPT +R G+ +
Sbjct: 413 SNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSL 472
Query: 461 GSTMARVGSIVSP-LVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDL 519
S + G I++P L+ A ++ +PL I+G + + +LLPET G LP+TV D+
Sbjct: 473 CSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDV 532
Query: 520 ESRWAPTQKEAGIYPRKGKQTRQQQEH 546
E +P + G + K+T + H
Sbjct: 533 EKLGSPHSCKCG----RNKKTPVSRSH 555
>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
Length = 555
Score = 261 bits (666), Expect = 2e-69
Identities = 179/570 (31%), Positives = 275/570 (48%), Gaps = 41/570 (7%)
Query: 4 NDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGL 63
+D+L+ G FQ+ L+ L A F P H CR P A LS G
Sbjct: 6 DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCG- 64
Query: 64 EVWLPRDR------------QGQPESCLRFTSPQWGLPFLNGTEANGTGATE-------P 104
W P + + P C R+ W + + + T P
Sbjct: 65 --WSPAEELNYTVPGPGPAGEASPRQCRRY-EVDWNQSTFDCVDPLASLDTNRSRLPLGP 121
Query: 105 CTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKV 164
C DGW+Y+ T S+IVTE++LVC++ + L QS VG +G+M GY+ADR GR+
Sbjct: 122 CRDGWVYE--TPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLC 179
Query: 165 LILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGT 224
L+ L A +G A +P + FRL+ G+ L L E++ R VG
Sbjct: 180 LLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGI 239
Query: 225 LIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLT 284
Y++G +LAGVAYA+PHWR LQ V+ P F F +Y W ES RW S +
Sbjct: 240 FYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEA 299
Query: 285 LRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSM 344
+R ++ +A+ NGK L + R L++E T K S ++L+R P +R + L
Sbjct: 300 MRIIKHIAKKNGK-----SLPASLQRLRLEEE-TGKKLNPSFLDLVRTPQIRKHTMILMY 353
Query: 345 LWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLL 404
WF +S Y GL+M + G +IYL V+ PA + L I+ +GRR A+ ++
Sbjct: 354 NWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMV 413
Query: 405 AGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTM 464
AG L + IP D ++ ++ LG+ + ++ + L ELYPT IR G+ + S+M
Sbjct: 414 AGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSM 473
Query: 465 ARVGSIVSP-LVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRW 523
+G I++P LV ++ +PL ++G + + A + +LLPET G+ LP+T+++ E+
Sbjct: 474 CDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQ 533
Query: 524 APTQKEAGIYPRKGKQTRQQQEHQKYMVPL 553
PRK K+ + QK +PL
Sbjct: 534 R---------PRKNKEKMIYLQVQKLDIPL 554
>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
sapiens]
Length = 554
Score = 255 bits (651), Expect = 9e-68
Identities = 175/538 (32%), Positives = 264/538 (49%), Gaps = 32/538 (5%)
Query: 4 NDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGL 63
+D+L+QVG G FQ+ ++ L A F P HHC+ P A LS+ G
Sbjct: 5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCG- 63
Query: 64 EVWLPRDRQGQPE------------SCLRFTSPQWGLPFLNGTEANGTGATE-------P 104
W P + C R+ W L+ + + AT P
Sbjct: 64 --WSPAEELNYTVPGLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASLATNRSHLPLGP 120
Query: 105 CTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKV 164
C DGW+YD T S+IVTE++LVC+ L QS G L G++ GY ADR GR+
Sbjct: 121 CQDGWVYD--TPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLC 178
Query: 165 LILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGT 224
L+ L AVSG AF+PN+ FRLL G+ G + TL E++ +R V
Sbjct: 179 LLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAI 238
Query: 225 LIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLT 284
+ +++G L G+AYA+PHWR LQL VS P F F +Y W ES RW S R
Sbjct: 239 MYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEA 298
Query: 285 LRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSM 344
++ + +A+ NGK A L M SL++++T K S +L R P LR L
Sbjct: 299 IKIMDHIAQKNGKLPP-ADLKM----LSLEEDVT-EKLSPSFADLFRTPRLRKRTFILMY 352
Query: 345 LWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLL 404
LWF S Y GL++ + ++YL + V++P + + I+ +GR + LL
Sbjct: 353 LWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLL 412
Query: 405 AGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTM 464
AG L+ I D + + +G+ + + I L ELYPT +R G+ + S++
Sbjct: 413 AGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSL 472
Query: 465 ARVGSIVSP-LVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES 521
+G I++P +V E++ ++PL ++ + + A+ VT+LLPET G LP+T++D E+
Sbjct: 473 CDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAEN 530
>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
Length = 557
Score = 238 bits (606), Expect = 1e-62
Identities = 161/528 (30%), Positives = 259/528 (49%), Gaps = 18/528 (3%)
Query: 3 FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLS---K 59
++++ +G G FQ++ L+ ++ F A P H CR P ANLS +
Sbjct: 4 YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWR 63
Query: 60 NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEAN-----GTGATEPCTDGWIYDNS 114
N + + L RD + P SC R+ G E G E C DGW +
Sbjct: 64 NHTVPLRL-RDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122
Query: 115 TFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY-LQTA 173
+ STIVTEW+LVC L SL+ VGVLLG+ + G L+DR GR+ VL + +QT
Sbjct: 123 VYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTG 182
Query: 174 VSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSL 232
S F+ NF ++ +L GM + L E + R TL + Y+
Sbjct: 183 FS-FLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAF 241
Query: 233 GQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVA 292
G +L AY + WR L + ++ P WF ES RW S GR + +++ A
Sbjct: 242 GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAA 301
Query: 293 RINGKREEGAKLSMEVLRASLQKELTMGKGQA-SAMELLRCPTLRHLFLCLSMLWFATSF 351
+ NG + + S ++L+ K Q+ + ++LLR +R + + MLW S
Sbjct: 302 KANG-----IVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISV 356
Query: 352 AYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL 411
Y+GL +D I++ + V++PA ++ +L++ L RR + AL L G +L
Sbjct: 357 GYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLF 416
Query: 412 NGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIV 471
++P D + T L ++GK + A+F+ +++YT ELYPT++R G+G+ ST +R+GSI+
Sbjct: 417 MQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL 476
Query: 472 SPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDL 519
SP +P + G++ + + +T+ LPE+ G PLPDT+ +
Sbjct: 477 SPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQM 524
>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
Length = 577
Score = 223 bits (568), Expect = 4e-58
Identities = 155/542 (28%), Positives = 253/542 (46%), Gaps = 35/542 (6%)
Query: 3 FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN------ 56
F + VG GRFQ++ + + H F P H CRPP + +
Sbjct: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65
Query: 57 -----------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPC 105
L +G + + + G+ R + + G E G+ PC
Sbjct: 66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPC 125
Query: 106 TDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVL 165
DG+IYD +T+ ST VT+W+LVC + L L Q L+M GVLLG++ FGY +DRLGRR VL
Sbjct: 126 VDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVL 185
Query: 166 ILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL 225
+ G AAFA ++ + A R M +G + +E++ + +R
Sbjct: 186 WATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVH 245
Query: 226 IGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTL 285
+ +++G L+A Y V W Q+++S F + W E+ W S GR +
Sbjct: 246 LHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQ 305
Query: 286 RALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLF------ 339
+ + +A+ N R KLS E+L LQ G S E+ + L +LF
Sbjct: 306 KIVDIMAKWN--RASSCKLS-ELLSLDLQ-----GPVSNSPTEVQK-HNLSYLFYNWSIT 356
Query: 340 ---LCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRP 396
L + ++WF S +Y ++ G + YL + G V++PA + ++ +GRR
Sbjct: 357 KRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRT 416
Query: 397 AQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQT 456
+L + + + VIPQ I+ A++GK + A+F I+LYT ELYPT++R
Sbjct: 417 VLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSL 476
Query: 457 GMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTV 516
+G GS + R+ SI++P + ++ +P G + + + +T+ LPETLG+ L T
Sbjct: 477 AVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTW 536
Query: 517 QD 518
++
Sbjct: 537 EE 538
>gi|157426885 organic cation transporter like 4 [Homo sapiens]
Length = 594
Score = 221 bits (564), Expect = 1e-57
Identities = 150/537 (27%), Positives = 263/537 (48%), Gaps = 40/537 (7%)
Query: 3 FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPP----ADANLS 58
F +LL VG G FQQ V L +P ++ A +F +C +LS
Sbjct: 52 FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLS 111
Query: 59 KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118
K L + +P+ G +C + W L + G T+ C DGWIY ++ S
Sbjct: 112 KAEQLNLTIPQAPNGSFLTCFMYLPVPWNL---DSIIQFGLNDTDTCQDGWIYPDAKKRS 168
Query: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178
++ E+DLVC + AQ ++M G+ +G+++F + D++GR ++L+ L + G
Sbjct: 169 -LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFG 227
Query: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238
AF +F +Y FR ++ G +++ ++L EW+ RA L +++G LL
Sbjct: 228 TAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLT 287
Query: 239 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR 298
G+AY++PHW+ L L+ F Y W ES RW G++ + L A +N K
Sbjct: 288 GIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKK- 346
Query: 299 EEGAKLSMEVLRASLQKELTMGK---GQASAMELLRCPTLRHLFLCLSMLWFATSFAYYG 355
+ ++L EL + + +AS ++ + L + L +S +WF S+ Y+
Sbjct: 347 ---------TIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFT 397
Query: 356 LVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVI 415
L + ++ GVS++ V+ +++PA+L ++ +GR+ + LL A I LL +
Sbjct: 398 LSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFL 457
Query: 416 PQDQSIVRTS---------------LAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGM 460
P+ + +R + +L + LAA+ FLYT EL PT++R TG+G+
Sbjct: 458 PEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGL 517
Query: 461 GSTMARVGSIVS-PLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTV 516
S + G+I+S ++S T L +P+F+ + + A +++ LLPET QPL +++
Sbjct: 518 VSLASVAGAILSLTIISQTPSL---LPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571
>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
Length = 551
Score = 219 bits (559), Expect = 4e-57
Identities = 153/556 (27%), Positives = 258/556 (46%), Gaps = 27/556 (4%)
Query: 3 FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLS---K 59
+++++ +G G FQ++ L+ ++ + F A P H CR P ANLS +
Sbjct: 4 YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWR 63
Query: 60 NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEAN-----GTGATEPCTDGWIYDNS 114
N + + L RD + P SC R+ G E G E C DGW +
Sbjct: 64 NNSVPLRL-RDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122
Query: 115 TFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAV 174
+ ST+VTEW+LVC L SL+ VGVLLG+ V G L+DR GR+ VL
Sbjct: 123 VYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTG 182
Query: 175 SGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSLG 233
F+ ++ ++ ++ GM + L E + R TL + +++G
Sbjct: 183 FSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVG 242
Query: 234 QFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVAR 293
LL AY + WR L L ++ P WF ES RW S R +Q+ A+
Sbjct: 243 YMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAK 302
Query: 294 INGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAY 353
+N V+ S+++ + + +A ++L R + + + +LW TS Y
Sbjct: 303 MNNIAVPA------VIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGY 356
Query: 354 YGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNG 413
+ L +D YL + +++PA + +L++ +L RR A L G +L
Sbjct: 357 FALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQ 416
Query: 414 VIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSP 473
++P D + L +LGK + ++F+ ++++T ELYPT++R +G+ ST +RVGSI++P
Sbjct: 417 LVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAP 476
Query: 474 LVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES-RWAPTQKEAGI 532
+P + G++ V +T+ PE+LG LP+T++ ++ +W
Sbjct: 477 YFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWF-------- 528
Query: 533 YPRKGKQTRQQQEHQK 548
R GK+TR E ++
Sbjct: 529 --RSGKKTRDSMETEE 542
>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
sapiens]
Length = 506
Score = 209 bits (533), Expect = 4e-54
Identities = 152/473 (32%), Positives = 219/473 (46%), Gaps = 31/473 (6%)
Query: 4 NDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGL 63
+D+L+QVG G FQ+ ++ L A F P HHC+ P A LS+ G
Sbjct: 5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCG- 63
Query: 64 EVWLPRDRQGQPE------------SCLRFTSPQWGLPFLNGTEANGTGATE-------P 104
W P + C R+ W L+ + + AT P
Sbjct: 64 --WSPAEELNYTVPGLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASLATNRSHLPLGP 120
Query: 105 CTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKV 164
C DGW+YD T S+IVTE++LVC+ L QS G L G++ GY ADR GR+
Sbjct: 121 CQDGWVYD--TPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLC 178
Query: 165 LILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGT 224
L+ L AVSG AF+PN+ FRLL G+ G + TL E++ +R V
Sbjct: 179 LLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAI 238
Query: 225 LIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLT 284
+ +++G L G+AYA+PHWR LQL VS P F F +Y W ES RW S R
Sbjct: 239 MYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEA 298
Query: 285 LRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSM 344
++ + +A+ NGK A L M SL++++T K S +L R P LR L
Sbjct: 299 IKIMDHIAQKNGKLPP-ADLKM----LSLEEDVT-EKLSPSFADLFRTPRLRKRTFILMY 352
Query: 345 LWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLL 404
LWF S Y GL++ + ++YL + V++P + + I+ +GR + LL
Sbjct: 353 LWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLL 412
Query: 405 AGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTG 457
AG L+ I D + + +G+ + + I L ELYPT + G
Sbjct: 413 AGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVG 465
>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
Length = 547
Score = 208 bits (529), Expect = 1e-53
Identities = 155/529 (29%), Positives = 248/529 (46%), Gaps = 41/529 (7%)
Query: 1 MAFNDLLQQVGGVGRFQQ-IQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSK 59
M + Q VG +G +Q + L VL L +A+ L A P++H
Sbjct: 1 MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHW---------- 50
Query: 60 NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPST 119
L LP G + W L NG+E + ++ +S+F S
Sbjct: 51 --DLAELLPNQSHGNQSAGEDQAFGDWLLT-ANGSEIHKH----------VHFSSSFTS- 96
Query: 120 IVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCA 179
I +EW L+ + A S + GV +G + FG L+DR GR+KV + + +
Sbjct: 97 IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIAN 156
Query: 180 AFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAG 239
F+P++ + R L GM G+SL L E + A G++ G +++G A
Sbjct: 157 GFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYAL 216
Query: 240 VAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKRE 299
+ Y + WR L +LV+ F+ S F ES RW S GRL AL +A+ N K +
Sbjct: 217 LGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLK 276
Query: 300 EGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMD 359
L+ R+ + S ++L R L L L +WF S YYGL +
Sbjct: 277 CTFSLTHPANRSC--------RETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLS 328
Query: 360 LQGFGVSIYLIQVIFGAVDLPAKLVGFLVINS--LGRRPAQMAALLLAGICILLNGVIPQ 417
G SIY + G +++P+ + +IN GR+ A L L G+ L+ +P+
Sbjct: 329 AGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPE 388
Query: 418 DQ-----SIVRT-SLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIV 471
+ ++V + SL++LGK ++A+FN +++YT ELYPT+IR G+G S +RVG I+
Sbjct: 389 KKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGII 448
Query: 472 SPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLE 520
+P + + S+P ++GA + + +++LLPETL PL +T DL+
Sbjct: 449 APFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497
>gi|170650643 solute carrier family 22, member 23 isoform a [Homo
sapiens]
Length = 686
Score = 130 bits (327), Expect = 3e-30
Identities = 105/458 (22%), Positives = 199/458 (43%), Gaps = 32/458 (6%)
Query: 89 PFLNGTEANGTGATEPCTDGWIYD-NSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLL 147
P L G A+ W Y + +V++WDLVC + +A+ +VG++
Sbjct: 183 PPLPSPPDKGDNASNCDCRAWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIF 242
Query: 148 GAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCM 207
G ++ G +AD +GRR VL+ + + + G A + N ++ R G LAGI L
Sbjct: 243 GYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLY 302
Query: 208 TLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWF 267
L +E P R + + +V GQFL+ G+A W+ LQ L+ PF +Y
Sbjct: 303 ALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSI 362
Query: 268 FIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAM 327
F ES RW ++ + + R + + N EG ++ + L+KEL+ + +
Sbjct: 363 FPESLRWLMATQQFESAKRLILHFTQKNRMNPEG---DIKGVIPELEKELSRRPKKVCIV 419
Query: 328 ELLRCPTL--RHLFLCLSMLWFATSFA-YYGLVMDLQGFGVSIYLIQVIF------GAVD 378
+++ L + LC++ L T + ++ + G V + L++ + ++
Sbjct: 420 KVVGTRNLWKNIVVLCVNSL---TGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIA 476
Query: 379 LPAKLVGFLVINSLGRRPAQMAALLLAGICILL----------------NGVIPQDQSIV 422
L + L +V+ LGRR + ++L + LL +G+ +
Sbjct: 477 LVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKF 536
Query: 423 RTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELY 482
+ +++G A + + E+ PT+IR G+G+ A G + +P++ + +
Sbjct: 537 SIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKG 596
Query: 483 PSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLE 520
+ I+ + +LLPE+ Q LP+ + + E
Sbjct: 597 YFLHHIIFACCTLICIICILLLPESRDQNLPENISNGE 634
>gi|24308167 SV2 related protein [Homo sapiens]
Length = 548
Score = 129 bits (324), Expect = 7e-30
Identities = 111/412 (26%), Positives = 189/412 (45%), Gaps = 47/412 (11%)
Query: 136 LAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLS 195
L S+ VG++ + ++G ++D+ GR+ L ++ L T G +AFAP + R L
Sbjct: 124 LLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLV 183
Query: 196 GMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQ-FLLAGVAYAVPH--WRHLQL 252
G + G+ +TL E++P+ RA LI +++G F + + +P WR L +
Sbjct: 184 GFGIGGVP-QSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLI 242
Query: 253 LVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRAS 312
L + P F + ++ ESAR+ SG + + L+R+A E GA + + L S
Sbjct: 243 LSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIA-----TENGAPMPLGKLIIS 297
Query: 313 LQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM---------DLQG- 362
Q++ GK M L P R L L +WF+ +F+YYGLV+ D+ G
Sbjct: 298 RQED--RGK-----MRDLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGI 350
Query: 363 -----------------FGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLA 405
Y+ + + P LV +I+ LGR+ ++
Sbjct: 351 SSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIF 410
Query: 406 GICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMA 465
C LL + V T L + + ++ F ++YT E+YPT R G+G S MA
Sbjct: 411 SFCSLLLFICVGRN--VLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMA 468
Query: 466 RVGSIVSPLVS-MTAELYPSMPLFIYGAVPVAASAVTVLLP-ETLGQPLPDT 515
RVG++++P ++ + E + L +Y + A+ + LP ET G+ L ++
Sbjct: 469 RVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520
>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
Length = 492
Score = 128 bits (321), Expect = 2e-29
Identities = 110/417 (26%), Positives = 188/417 (45%), Gaps = 56/417 (13%)
Query: 136 LAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLS 195
L ++ G ++ +++FG LADR GR K+L++++L A +FAP++ + R +
Sbjct: 88 LVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMV 147
Query: 196 GMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAV---PHWRHLQL 252
G ++G S + + E++P R + L + G L+ G+A + WR L
Sbjct: 148 GCGVSGHSQG-LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIR 206
Query: 253 LVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRAS 312
+ S P + F ESAR++ S+G L L+RVA++N KL VL
Sbjct: 207 VASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL--- 263
Query: 313 LQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM--------DL---- 360
+ + +LL LR L + ++W SFAYYG+++ DL
Sbjct: 264 --------EKRGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGS 314
Query: 361 ----------------------QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQ 398
F S Y +I ++ + L IN LGRR +
Sbjct: 315 KSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSL 374
Query: 399 MAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGM 458
+ + LL + ++ + + +AA+FN +++YT E+YPT +R GM
Sbjct: 375 SITMGCTALFFLLLNICTSSAGLI--GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGM 432
Query: 459 GMGSTMARVGSIVSPLVS---MTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPL 512
G ++ R+G++V+P +S M+A + ++ LF V A SA T+ + ET G+ L
Sbjct: 433 GTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPI-ETKGRAL 488
>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
sapiens]
Length = 520
Score = 123 bits (308), Expect = 5e-28
Identities = 117/432 (27%), Positives = 182/432 (42%), Gaps = 26/432 (6%)
Query: 105 CTDGWIYDNSTFPST-IVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRK 163
C W Y+ +T + +WDLVC L Q L+++G G + GY ADR GRR
Sbjct: 70 CLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRG 129
Query: 164 VLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTR---A 220
+++L G A A + A R L G LAG+ L + +E R A
Sbjct: 130 IVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVA 189
Query: 221 CVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSW--FFIESARWHSSS 278
G L+G G FL G+A WR LQ +++AP F Y W F+ESARW
Sbjct: 190 LAGELVGVG---GHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVK 246
Query: 279 GRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHL 338
+++ L+ +A N R G L E A E T S+ R++
Sbjct: 247 RQIEEAQSVLRILAERN--RPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNI 304
Query: 339 FLCLSMLWFATSFAYYGLVMDLQGFG-----VSIYLIQVIFGAVDLPAKLVGFLVINSLG 393
+ L +L F T+F + + Q G YL ++ A + + ++ G
Sbjct: 305 WKNLLILGF-TNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFG 363
Query: 394 RRPAQMAALLLAGIC-ILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTM 452
RR + ++ L GI ++L G+ T+ +VLG A+ L E+ PT
Sbjct: 364 RRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTT 423
Query: 453 IRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTV----LLPETL 508
+R G+G+ + +G + P L+ F+ V A + + + LLPET
Sbjct: 424 VRGRGLGLIMALGALGGLSGP----AQRLHMGHGAFLQHVVLAACALLCILSIMLLPETK 479
Query: 509 GQPLPDTVQDLE 520
+ LP+ ++D E
Sbjct: 480 RKLLPEVLRDGE 491
>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
[Homo sapiens]
Length = 558
Score = 122 bits (307), Expect = 7e-28
Identities = 130/535 (24%), Positives = 212/535 (39%), Gaps = 38/535 (7%)
Query: 6 LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRP------PADANLSK 59
+L+ GG GR +++ + +P +++ + + A P HCRP PA L
Sbjct: 7 VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
Query: 60 NGGLEVWLPR-DRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118
L+ +PR P L SP + P + + G
Sbjct: 67 PALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAG---------- 116
Query: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178
W+LVC L Q +++G LLG ++ G DR GRR V + + + T G
Sbjct: 117 ---PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGAS 173
Query: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238
A A +FP RLL G LAG L +E R G +G LL
Sbjct: 174 EALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLP 233
Query: 239 GVAYAVPHWRHLQ---LLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARIN 295
G+A V WR LQ L+S F+ + F ES W ++G++ + L R A +
Sbjct: 234 GLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS 293
Query: 296 GKREEGAKLSMEVLRASLQKELTMGKGQA------SAMELLRCPTLRHLFLCLSMLWFAT 349
G + L L + ELTM ++ S + LLR L L
Sbjct: 294 GVGPGDSSLEENSLATA--TELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVG 351
Query: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGIC- 408
L + YL + ++ A + L + GRRP + ++ G+
Sbjct: 352 GGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLAS 411
Query: 409 -ILLNGV--IPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMA 465
+LL G +P + + L +L ++A + L+ E++PT+IR G+G+
Sbjct: 412 LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSS---LFAAEVFPTVIRGAGLGLVLGAG 468
Query: 466 RVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLE 520
+G PL ++ + ++ ++ V A +LLPE+ + LP ++QD +
Sbjct: 469 FLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDAD 523
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.138 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,093,721
Number of Sequences: 37866
Number of extensions: 895338
Number of successful extensions: 2905
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 2704
Number of HSP's gapped (non-prelim): 100
length of query: 563
length of database: 18,247,518
effective HSP length: 107
effective length of query: 456
effective length of database: 14,195,856
effective search space: 6473310336
effective search space used: 6473310336
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.