Guide to the Human Genome
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Search of human proteins with 199559438

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|199559438 Abelson helper integration site 1 isoform a [Homo
sapiens]
         (1196 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|199559490 Abelson helper integration site 1 isoform a [Homo s...  2440   0.0  
gi|199559438 Abelson helper integration site 1 isoform a [Homo s...  2440   0.0  
gi|31542701 Abelson helper integration site 1 isoform a [Homo sa...  2440   0.0  
gi|199559532 Abelson helper integration site 1 isoform b [Homo s...  2114   0.0  
gi|16554629 WD repeat domain 5 [Homo sapiens]                         111   4e-24
gi|16554627 WD repeat domain 5 [Homo sapiens]                         111   4e-24
gi|23199987 WD repeat domain 5B [Homo sapiens]                        111   5e-24
gi|45238858 WD repeat domain 44 protein [Homo sapiens]                 92   3e-18
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    80   1e-14
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]          74   1e-12
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]          74   1e-12
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ...    73   2e-12
gi|147904340 WD repeat domain 82 [Homo sapiens]                        69   2e-11
gi|8923881 WD SOCS-box protein 2 [Homo sapiens]                        68   5e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     67   1e-10
gi|26665869 WD repeat domain 51B [Homo sapiens]                        67   1e-10
gi|32189425 WD repeat domain 69 [Homo sapiens]                         65   3e-10
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H...    63   1e-09
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             63   1e-09
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             63   1e-09
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             63   1e-09
gi|53759148 retinoblastoma binding protein 5 [Homo sapiens]            63   1e-09
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ...    61   7e-09
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s...    61   7e-09
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...    60   9e-09
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    60   9e-09
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    60   9e-09
gi|194294525 intersectin 2 isoform 2 [Homo sapiens]                    60   9e-09
gi|5174447 guanine nucleotide binding protein (G protein), beta ...    60   2e-08
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                59   2e-08

>gi|199559490 Abelson helper integration site 1 isoform a [Homo
            sapiens]
          Length = 1196

 Score = 2440 bits (6324), Expect = 0.0
 Identities = 1196/1196 (100%), Positives = 1196/1196 (100%)

Query: 1    MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETT 60
            MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETT
Sbjct: 1    MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETT 60

Query: 61   SDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEED 120
            SDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEED
Sbjct: 61   SDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEED 120

Query: 121  KQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREET 180
            KQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREET
Sbjct: 121  KQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREET 180

Query: 181  DLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKE 240
            DLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKE
Sbjct: 181  DLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKE 240

Query: 241  VPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPK 300
            VPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPK
Sbjct: 241  VPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPK 300

Query: 301  PKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFM 360
            PKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFM
Sbjct: 301  PKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFM 360

Query: 361  ISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEW 420
            ISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEW
Sbjct: 361  ISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEW 420

Query: 421  EEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLK 480
            EEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLK
Sbjct: 421  EEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLK 480

Query: 481  LLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVP 540
            LLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVP
Sbjct: 481  LLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVP 540

Query: 541  DCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNK 600
            DCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNK
Sbjct: 541  DCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNK 600

Query: 601  HLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDL 660
            HLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDL
Sbjct: 601  HLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDL 660

Query: 661  SWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDS 720
            SWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDS
Sbjct: 661  SWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDS 720

Query: 721  MIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDL 780
            MIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDL
Sbjct: 721  MIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDL 780

Query: 781  EHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGA 840
            EHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGA
Sbjct: 781  EHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGA 840

Query: 841  ANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFEN 900
            ANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFEN
Sbjct: 841  ANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFEN 900

Query: 901  MVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGS 960
            MVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGS
Sbjct: 901  MVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGS 960

Query: 961  FQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSN 1020
            FQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSN
Sbjct: 961  FQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSN 1020

Query: 1021 MLTAQEILHQFGFTQTGIISIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRV 1080
            MLTAQEILHQFGFTQTGIISIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRV
Sbjct: 1021 MLTAQEILHQFGFTQTGIISIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRV 1080

Query: 1081 FFKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERSPPLSPEEKTKIEKSPAP 1140
            FFKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERSPPLSPEEKTKIEKSPAP
Sbjct: 1081 FFKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERSPPLSPEEKTKIEKSPAP 1140

Query: 1141 QKQSINKNKSQDFRLGSESMTHSEMRKEQSHEDQGHIMDTRMRKNKQAGRKVTLIE 1196
            QKQSINKNKSQDFRLGSESMTHSEMRKEQSHEDQGHIMDTRMRKNKQAGRKVTLIE
Sbjct: 1141 QKQSINKNKSQDFRLGSESMTHSEMRKEQSHEDQGHIMDTRMRKNKQAGRKVTLIE 1196


>gi|199559438 Abelson helper integration site 1 isoform a [Homo
            sapiens]
          Length = 1196

 Score = 2440 bits (6324), Expect = 0.0
 Identities = 1196/1196 (100%), Positives = 1196/1196 (100%)

Query: 1    MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETT 60
            MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETT
Sbjct: 1    MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETT 60

Query: 61   SDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEED 120
            SDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEED
Sbjct: 61   SDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEED 120

Query: 121  KQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREET 180
            KQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREET
Sbjct: 121  KQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREET 180

Query: 181  DLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKE 240
            DLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKE
Sbjct: 181  DLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKE 240

Query: 241  VPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPK 300
            VPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPK
Sbjct: 241  VPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPK 300

Query: 301  PKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFM 360
            PKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFM
Sbjct: 301  PKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFM 360

Query: 361  ISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEW 420
            ISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEW
Sbjct: 361  ISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEW 420

Query: 421  EEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLK 480
            EEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLK
Sbjct: 421  EEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLK 480

Query: 481  LLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVP 540
            LLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVP
Sbjct: 481  LLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVP 540

Query: 541  DCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNK 600
            DCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNK
Sbjct: 541  DCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNK 600

Query: 601  HLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDL 660
            HLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDL
Sbjct: 601  HLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDL 660

Query: 661  SWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDS 720
            SWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDS
Sbjct: 661  SWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDS 720

Query: 721  MIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDL 780
            MIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDL
Sbjct: 721  MIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDL 780

Query: 781  EHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGA 840
            EHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGA
Sbjct: 781  EHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGA 840

Query: 841  ANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFEN 900
            ANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFEN
Sbjct: 841  ANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFEN 900

Query: 901  MVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGS 960
            MVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGS
Sbjct: 901  MVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGS 960

Query: 961  FQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSN 1020
            FQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSN
Sbjct: 961  FQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSN 1020

Query: 1021 MLTAQEILHQFGFTQTGIISIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRV 1080
            MLTAQEILHQFGFTQTGIISIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRV
Sbjct: 1021 MLTAQEILHQFGFTQTGIISIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRV 1080

Query: 1081 FFKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERSPPLSPEEKTKIEKSPAP 1140
            FFKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERSPPLSPEEKTKIEKSPAP
Sbjct: 1081 FFKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERSPPLSPEEKTKIEKSPAP 1140

Query: 1141 QKQSINKNKSQDFRLGSESMTHSEMRKEQSHEDQGHIMDTRMRKNKQAGRKVTLIE 1196
            QKQSINKNKSQDFRLGSESMTHSEMRKEQSHEDQGHIMDTRMRKNKQAGRKVTLIE
Sbjct: 1141 QKQSINKNKSQDFRLGSESMTHSEMRKEQSHEDQGHIMDTRMRKNKQAGRKVTLIE 1196


>gi|31542701 Abelson helper integration site 1 isoform a [Homo
            sapiens]
          Length = 1196

 Score = 2440 bits (6324), Expect = 0.0
 Identities = 1196/1196 (100%), Positives = 1196/1196 (100%)

Query: 1    MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETT 60
            MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETT
Sbjct: 1    MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETT 60

Query: 61   SDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEED 120
            SDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEED
Sbjct: 61   SDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEED 120

Query: 121  KQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREET 180
            KQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREET
Sbjct: 121  KQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREET 180

Query: 181  DLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKE 240
            DLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKE
Sbjct: 181  DLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKE 240

Query: 241  VPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPK 300
            VPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPK
Sbjct: 241  VPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPK 300

Query: 301  PKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFM 360
            PKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFM
Sbjct: 301  PKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFM 360

Query: 361  ISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEW 420
            ISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEW
Sbjct: 361  ISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEW 420

Query: 421  EEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLK 480
            EEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLK
Sbjct: 421  EEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLK 480

Query: 481  LLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVP 540
            LLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVP
Sbjct: 481  LLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVP 540

Query: 541  DCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNK 600
            DCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNK
Sbjct: 541  DCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNK 600

Query: 601  HLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDL 660
            HLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDL
Sbjct: 601  HLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDL 660

Query: 661  SWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDS 720
            SWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDS
Sbjct: 661  SWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDS 720

Query: 721  MIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDL 780
            MIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDL
Sbjct: 721  MIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDL 780

Query: 781  EHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGA 840
            EHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGA
Sbjct: 781  EHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGA 840

Query: 841  ANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFEN 900
            ANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFEN
Sbjct: 841  ANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFEN 900

Query: 901  MVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGS 960
            MVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGS
Sbjct: 901  MVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGS 960

Query: 961  FQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSN 1020
            FQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSN
Sbjct: 961  FQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSN 1020

Query: 1021 MLTAQEILHQFGFTQTGIISIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRV 1080
            MLTAQEILHQFGFTQTGIISIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRV
Sbjct: 1021 MLTAQEILHQFGFTQTGIISIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRV 1080

Query: 1081 FFKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERSPPLSPEEKTKIEKSPAP 1140
            FFKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERSPPLSPEEKTKIEKSPAP
Sbjct: 1081 FFKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERSPPLSPEEKTKIEKSPAP 1140

Query: 1141 QKQSINKNKSQDFRLGSESMTHSEMRKEQSHEDQGHIMDTRMRKNKQAGRKVTLIE 1196
            QKQSINKNKSQDFRLGSESMTHSEMRKEQSHEDQGHIMDTRMRKNKQAGRKVTLIE
Sbjct: 1141 QKQSINKNKSQDFRLGSESMTHSEMRKEQSHEDQGHIMDTRMRKNKQAGRKVTLIE 1196


>gi|199559532 Abelson helper integration site 1 isoform b [Homo
            sapiens]
          Length = 1053

 Score = 2114 bits (5477), Expect = 0.0
 Identities = 1038/1046 (99%), Positives = 1038/1046 (99%)

Query: 1    MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETT 60
            MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETT
Sbjct: 1    MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETT 60

Query: 61   SDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEED 120
            SDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEED
Sbjct: 61   SDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEED 120

Query: 121  KQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREET 180
            KQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREET
Sbjct: 121  KQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREET 180

Query: 181  DLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKE 240
            DLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKE
Sbjct: 181  DLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKE 240

Query: 241  VPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPK 300
            VPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPK
Sbjct: 241  VPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPK 300

Query: 301  PKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFM 360
            PKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFM
Sbjct: 301  PKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFM 360

Query: 361  ISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEW 420
            ISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEW
Sbjct: 361  ISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEW 420

Query: 421  EEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLK 480
            EEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLK
Sbjct: 421  EEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLK 480

Query: 481  LLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVP 540
            LLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVP
Sbjct: 481  LLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVP 540

Query: 541  DCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNK 600
            DCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNK
Sbjct: 541  DCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNK 600

Query: 601  HLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDL 660
            HLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDL
Sbjct: 601  HLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDL 660

Query: 661  SWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDS 720
            SWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDS
Sbjct: 661  SWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDS 720

Query: 721  MIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDL 780
            MIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDL
Sbjct: 721  MIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDL 780

Query: 781  EHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGA 840
            EHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGA
Sbjct: 781  EHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGA 840

Query: 841  ANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFEN 900
            ANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFEN
Sbjct: 841  ANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFEN 900

Query: 901  MVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGS 960
            MVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGS
Sbjct: 901  MVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGS 960

Query: 961  FQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSN 1020
            FQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSN
Sbjct: 961  FQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSN 1020

Query: 1021 MLTAQEILHQFGFTQTGIISIERKPC 1046
            MLTAQEILHQFGFTQT     E   C
Sbjct: 1021 MLTAQEILHQFGFTQTDSHFAEFNTC 1046


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  111 bits (278), Expect = 4e-24
 Identities = 84/328 (25%), Positives = 161/328 (49%), Gaps = 33/328 (10%)

Query: 598 PNKHL-FSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNI 656
           PN  L F+L    +    + FS NG  LA++ A +    I ++    G+F + + GH   
Sbjct: 33  PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADK---LIKIWGAYDGKFEKTISGHKLG 89

Query: 657 IYDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLP-HPSFVYTAKFHPAVRELVVT 715
           I D++WS D + ++++S D T +IW  ++++    + L  H ++V+   F+P    L+V+
Sbjct: 90  ISDVAWSSDSNLLVSASDDKTLKIW--DVSSGKCLKTLKGHSNYVFCCNFNPQ-SNLIVS 146

Query: 716 GCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYV 775
           G +D  +RIW V+  +     ++    H   ++++ F+ +G  + S    G+  +W+T  
Sbjct: 147 GSFDESVRIWDVKTGK----CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT-- 200

Query: 776 KINDLEHSVHHWTINKEIKET--EFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDL-RIL 832
                         + +  +T  +    P+S+++  PNGK +L  T D+TL++ D  +  
Sbjct: 201 -------------ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 247

Query: 833 VARKFVGAANYREKIHSTLTPC-GTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIR 891
             + + G  N +  I +  +   G ++ +GSED +VY+WN +T E V           + 
Sbjct: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG--HTDVVI 305

Query: 892 DISYHPFENMVAFCAFGQNEPILLYIYD 919
             + HP EN++A  A   ++ I L+  D
Sbjct: 306 STACHPTENIIASAALENDKTIKLWKSD 333


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  111 bits (278), Expect = 4e-24
 Identities = 84/328 (25%), Positives = 161/328 (49%), Gaps = 33/328 (10%)

Query: 598 PNKHL-FSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNI 656
           PN  L F+L    +    + FS NG  LA++ A +    I ++    G+F + + GH   
Sbjct: 33  PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADK---LIKIWGAYDGKFEKTISGHKLG 89

Query: 657 IYDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLP-HPSFVYTAKFHPAVRELVVT 715
           I D++WS D + ++++S D T +IW  ++++    + L  H ++V+   F+P    L+V+
Sbjct: 90  ISDVAWSSDSNLLVSASDDKTLKIW--DVSSGKCLKTLKGHSNYVFCCNFNPQ-SNLIVS 146

Query: 716 GCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYV 775
           G +D  +RIW V+  +     ++    H   ++++ F+ +G  + S    G+  +W+T  
Sbjct: 147 GSFDESVRIWDVKTGK----CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT-- 200

Query: 776 KINDLEHSVHHWTINKEIKET--EFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDL-RIL 832
                         + +  +T  +    P+S+++  PNGK +L  T D+TL++ D  +  
Sbjct: 201 -------------ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 247

Query: 833 VARKFVGAANYREKIHSTLTPC-GTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIR 891
             + + G  N +  I +  +   G ++ +GSED +VY+WN +T E V           + 
Sbjct: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG--HTDVVI 305

Query: 892 DISYHPFENMVAFCAFGQNEPILLYIYD 919
             + HP EN++A  A   ++ I L+  D
Sbjct: 306 STACHPTENIIASAALENDKTIKLWKSD 333


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  111 bits (277), Expect = 5e-24
 Identities = 78/304 (25%), Positives = 151/304 (49%), Gaps = 28/304 (9%)

Query: 617 FSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDG 676
           FS NG  LA++ A R    II++    G++ + L GH   I D++WS D   ++++S D 
Sbjct: 49  FSPNGEWLASSSADR---LIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDK 105

Query: 677 TARIWKNEINNTNTFRVLP-HPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAI 735
           T ++W  ++ +    + L  H ++V+   F+P    L+++G +D  ++IW+V+  +    
Sbjct: 106 TLKLW--DVRSGKCLKTLKGHSNYVFCCNFNPP-SNLIISGSFDETVKIWEVKTGK---- 158

Query: 736 LVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKEIKE 795
            ++    H   ++++ F+  G  + SG   G+  +W+                  K + +
Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA-----------SGQCLKTLVD 207

Query: 796 TEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDL-RILVARKFVGAANYREKIHSTLTPC 854
            +    P+S+++  PNGK +L  T D+TL++ D  R    + + G  N +  I +  +  
Sbjct: 208 DD--NPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVT 265

Query: 855 -GTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFENMVAFCAFGQNEPI 913
            G ++ +GSED +VY+WN +T E V           +   + HP EN++A  A   ++ I
Sbjct: 266 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQG--HTDVVISAACHPTENLIASAALENDKTI 323

Query: 914 LLYI 917
            L++
Sbjct: 324 KLWM 327


>gi|45238858 WD repeat domain 44 protein [Homo sapiens]
          Length = 913

 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 64/222 (28%), Positives = 105/222 (47%), Gaps = 14/222 (6%)

Query: 652 GHLNIIYDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRE 711
           GH   + DLSWSK+ +++L+SS D T R+W   I+         H  FV    FHP    
Sbjct: 605 GHTADLLDLSWSKN-YFLLSSSMDKTVRLW--HISRRECLCCFQHIDFVTAIAFHPRDDR 661

Query: 712 LVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVW 771
             ++G  D  +R+W +   +    L  + D     I +  F   G +   G   G  + +
Sbjct: 662 YFLSGSLDGKLRLWNIP--DKKVALWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFY 719

Query: 772 NTYVKINDLEHSVHHWTINKEIKETEFK-GIPISYLEIHPNGKRLLIHTKDSTLRIMDLR 830
           +T       EH  +H  I+        K G  I+ +E  P   ++L+ + DS +R+ DLR
Sbjct: 720 DT-------EHLKYHTQIHVRSTRGRNKVGRKITGIEPLPGENKILVTSNDSRIRLYDLR 772

Query: 831 IL-VARKFVGAANYREKIHSTLTPCGTFLFAGSEDGIVYVWN 871
            L ++ K+ G  N   +I ++ +   T+L +GSED  VY+W+
Sbjct: 773 DLSLSMKYKGYVNSSSQIKASFSHDFTYLVSGSEDKYVYIWS 814


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 90/369 (24%), Positives = 158/369 (42%), Gaps = 43/369 (11%)

Query: 550 MMALQEEKGK-----PVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQA-CRIPNKHLF 603
           M+  Q+ KG      PV  +RH       + PG  + +         G   C      + 
Sbjct: 1   MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM 60

Query: 604 SLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSG-RFMRELCGHLNIIYDLSW 662
            L+  E   +C  F  NG  LA+A   R    I+L+ +         L GH   + +L +
Sbjct: 61  LLSGHEGEVYCCKFHPNGSTLASAGFDR---LILLWNVYGDCDNYATLKGHSGAVMELHY 117

Query: 663 SKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVR--ELVVTGCYDS 720
           + D   + ++S+D T  +W +E       R+  H SFV +   +PA R  +LV TG  D 
Sbjct: 118 NTDGSMLFSASTDKTVAVWDSE-TGERVKRLKGHTSFVNSC--YPARRGPQLVCTGSDDG 174

Query: 721 MIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDL 780
            +++W  ++R+ +AI   Q   +   + ++ F+     + SG     I VW       DL
Sbjct: 175 TVKLW--DIRKKAAIQTFQ---NTYQVLAVTFNDTSDQIISGGIDNDIKVW-------DL 222

Query: 781 EHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARK---- 836
             +   +T+             ++ L +   G  LL +  D+T+R+ D+R    ++    
Sbjct: 223 RQNKLTYTMRGHADS-------VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVK 275

Query: 837 -FVGAANYREK--IHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDI 893
            F G  +  EK  +  + +P G+ + AGS D  VYVW  +T  +  +Y        I ++
Sbjct: 276 IFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW--DTTSRRILYKLPGHAGSINEV 333

Query: 894 SYHPFENMV 902
           ++HP E ++
Sbjct: 334 AFHPDEPII 342



 Score = 32.0 bits (71), Expect = 3.6
 Identities = 22/77 (28%), Positives = 41/77 (53%), Gaps = 5/77 (6%)

Query: 609 ERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHY 668
           E+      +S +G  +AA  A R  Y   +++  S R + +L GH   I ++++  D+  
Sbjct: 285 EKNLLRCSWSPDGSKIAAGSADRFVY---VWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341

Query: 669 ILTSSSDGTARIWKNEI 685
           I+++SSD   R++  EI
Sbjct: 342 IISASSD--KRLYMGEI 356


>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
          Length = 607

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 81/337 (24%), Positives = 145/337 (43%), Gaps = 56/337 (16%)

Query: 571 SVDTEPGLEESKEVIKWKRLPGQACRIPNKHLFSLNAGERGCFCLDFSHNGRILAAACAS 630
           +VDT PG    KEV    R+P  A  + + H   +NA       + FS   R+LA     
Sbjct: 297 NVDTHPG--SGKEV----RVPATALCVFDAHDGEVNA-------VQFSPGSRLLATGGMD 343

Query: 631 RDGYPIILYEIPSGR--FMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKNE---I 685
           R    + L+E+   +  F   L G    I  + +     Y+L +S+D  +RIW  +   +
Sbjct: 344 RR---VKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRL 400

Query: 686 NNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKS 745
            +T T     H   V +AKF       +V+G +D  +++W +  +               
Sbjct: 401 RHTLT----GHSGKVLSAKFL-LDNARIVSGSHDRTLKLWDLRSK--------------- 440

Query: 746 FINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKE--IKETEFKGIPI 803
               +C  T    +++G     IV     V     +  +  W I  E  ++E E  G  I
Sbjct: 441 ----VCIKT----VFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLG-KI 491

Query: 804 SYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGAANYR---EKIHSTLTPCGTFLFA 860
           + L+++P    LL  ++D  L+++DLR    ++   A  ++   +      +P G+++ A
Sbjct: 492 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 551

Query: 861 GSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHP 897
           GS +G +Y+W+  TG+   + S     S I  +++ P
Sbjct: 552 GSAEGSLYIWSVLTGKVEKVLSK-QHSSSINAVAWSP 587


>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
          Length = 588

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 81/337 (24%), Positives = 145/337 (43%), Gaps = 56/337 (16%)

Query: 571 SVDTEPGLEESKEVIKWKRLPGQACRIPNKHLFSLNAGERGCFCLDFSHNGRILAAACAS 630
           +VDT PG    KEV    R+P  A  + + H   +NA       + FS   R+LA     
Sbjct: 278 NVDTHPG--SGKEV----RVPATALCVFDAHDGEVNA-------VQFSPGSRLLATGGMD 324

Query: 631 RDGYPIILYEIPSGR--FMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKNE---I 685
           R    + L+E+   +  F   L G    I  + +     Y+L +S+D  +RIW  +   +
Sbjct: 325 RR---VKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRL 381

Query: 686 NNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKS 745
            +T T     H   V +AKF       +V+G +D  +++W +  +               
Sbjct: 382 RHTLT----GHSGKVLSAKFL-LDNARIVSGSHDRTLKLWDLRSK--------------- 421

Query: 746 FINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKE--IKETEFKGIPI 803
               +C  T    +++G     IV     V     +  +  W I  E  ++E E  G  I
Sbjct: 422 ----VCIKT----VFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLG-KI 472

Query: 804 SYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGAANYR---EKIHSTLTPCGTFLFA 860
           + L+++P    LL  ++D  L+++DLR    ++   A  ++   +      +P G+++ A
Sbjct: 473 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 532

Query: 861 GSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHP 897
           GS +G +Y+W+  TG+   + S     S I  +++ P
Sbjct: 533 GSAEGSLYIWSVLTGKVEKVLSK-QHSSSINAVAWSP 568


>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
           sapiens]
          Length = 513

 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 63/300 (21%), Positives = 136/300 (45%), Gaps = 28/300 (9%)

Query: 614 CLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHL--------NIIYDLSWSKD 665
           C  FS +G+ L     S DG+ I ++   +G+  ++L            + +  + +S+D
Sbjct: 219 CARFSPDGQYLVTG--SVDGF-IEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRD 275

Query: 666 DHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIW 725
              + T + DG  ++WK +           H   V    F     + +++  +D  IRI 
Sbjct: 276 TEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ-ILSASFDQTIRIH 334

Query: 726 KVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVH 785
            ++    S   +++F  H SF+N   F  +GH++ S    G + +WN  +K  +  ++  
Sbjct: 335 GLK----SGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN--MKTTECSNTF- 387

Query: 786 HWTINKEIKETEFKGIPISYLEIHP-NGKRLLIHTKDSTLRIMDLRILVARKF-VGAANY 843
                K +  T    I ++ + + P N +  ++  + +T+ IM+++  + R F  G    
Sbjct: 388 -----KSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREG 442

Query: 844 REKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFENMVA 903
            + +   L+P G +++   ED ++Y ++  TG+     +    +  +  I++HP +N++A
Sbjct: 443 GDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLT--VHEKDVIGIAHHPHQNLIA 500



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 39/128 (30%), Positives = 68/128 (53%), Gaps = 14/128 (10%)

Query: 571 SVDTE---PGLEESKEVIKWKRLPGQACRIPNKHLFSLNAGERGCFCLDFSHNGRILAAA 627
           S DTE    G ++ K  + WK   GQ  R   +      A  +G  CL FS +   + +A
Sbjct: 273 SRDTEMLATGAQDGKIKV-WKIQSGQCLRRFER------AHSKGVTCLSFSKDSSQILSA 325

Query: 628 CASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKNEINN 687
              +    I ++ + SG+ ++E  GH + + + ++++D HYI+++SSDGT +IW  +   
Sbjct: 326 SFDQT---IRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTE 382

Query: 688 -TNTFRVL 694
            +NTF+ L
Sbjct: 383 CSNTFKSL 390


>gi|147904340 WD repeat domain 82 [Homo sapiens]
          Length = 313

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 77/299 (25%), Positives = 128/299 (42%), Gaps = 28/299 (9%)

Query: 614 CLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSS 673
           C DFS NG  + +   S D   I+LY+   G+  R L      +  + ++   + ++ SS
Sbjct: 26  CFDFSPNGETVIS---SSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSS 82

Query: 674 SDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDS 733
           +     I    +++    R  P  S    A     V +  ++G  D  IR+W +      
Sbjct: 83  NKIDDTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQ 142

Query: 734 AILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEH--SVHHWTINK 791
            ++      H        FD EG    +G       V +  VK+ DL         T   
Sbjct: 143 GLM------HLQGKPVCSFDPEGLIFAAG-------VNSEMVKLYDLRSFDKGPFATFKM 189

Query: 792 EIKET-EFKGIPISYLEIHPNGKRLLIHTKDSTLRIMD-LRILVARKFVGAANYRE-KIH 848
           +   T E+ G+  S      +GK +LI T  S +R++D  + +V   F G AN +   + 
Sbjct: 190 QYDRTCEWTGLKFSN-----DGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSKAVTLE 244

Query: 849 STLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHP-FENMVAFCA 906
           ++ TP   F+  GSEDG ++VWN E+G +VA+  D     PI  + ++P F    + C+
Sbjct: 245 ASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVL-DGKHTGPITCLQFNPKFMTFASACS 302


>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
          Length = 404

 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 57/248 (22%), Positives = 104/248 (41%), Gaps = 12/248 (4%)

Query: 624 LAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSS-DGTARIWK 682
           L  A    DG  I ++E+ +G  +  L GH +++ DLS++     IL S+S D T RIW 
Sbjct: 124 LVLATGLNDGQ-IKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWD 182

Query: 683 NEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDV 742
              +      +  H  +VY     P    ++ +   +  + +W +     S  L+R+ + 
Sbjct: 183 LNKHGKQIQVLSGHLQWVYCCSISPDC-SMLCSAAGEKSVFLWSMR----SYTLIRKLEG 237

Query: 743 HKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKEIKETEFKGIP 802
           H+S + S  F  +   + +      +++W+ Y    +   S+HH  ++  + +++     
Sbjct: 238 HQSSVVSCDFSPDSALLVTASYDTNVIMWDPYT--GERLRSLHHTQVDPAMDDSDVHISS 295

Query: 803 ISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGAANYREKIHSTLTPCGTFLFAGS 862
           +  +   P G  L     D  LRI  L +     F    N    +  T  P G  +  G+
Sbjct: 296 LRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTN---GLCCTFFPHGGVIATGT 352

Query: 863 EDGIVYVW 870
            DG V  W
Sbjct: 353 RDGHVQFW 360



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 42/190 (22%), Positives = 79/190 (41%), Gaps = 29/190 (15%)

Query: 697 PSFVYTAKFHPAVREL----VVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCF 752
           PS    A+ HP V ++    + TG  D  I+IW+V+    + +L+     H+  +  L F
Sbjct: 106 PSRKLWARHHPQVPDVSCLVLATGLNDGQIKIWEVQ----TGLLLLNLSGHQDVVRDLSF 161

Query: 753 DTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKEIKETEFKGIPISYL---EIH 809
              G          +I+V  +  K      ++  W +NK  K+ +     + ++    I 
Sbjct: 162 TPSG---------SLILVSASRDK------TLRIWDLNKHGKQIQVLSGHLQWVYCCSIS 206

Query: 810 PNGKRLLIHTKDSTLRIMDLR-ILVARKFVGAANYREKIHSTLTPCGTFLFAGSEDGIVY 868
           P+   L     + ++ +  +R   + RK  G  +    +    +P    L   S D  V 
Sbjct: 207 PDCSMLCSAAGEKSVFLWSMRSYTLIRKLEG--HQSSVVSCDFSPDSALLVTASYDTNVI 264

Query: 869 VWNPETGEQV 878
           +W+P TGE++
Sbjct: 265 MWDPYTGERL 274


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 64/260 (24%), Positives = 108/260 (41%), Gaps = 35/260 (13%)

Query: 620 NGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTAR 679
           +GR+LA      D   + L+ I     +  L GH + +  +  +  +  I+  S  G+ R
Sbjct: 32  SGRLLATG---GDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIR 88

Query: 680 IWKNEINNTNTFRVLP-HPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVR 738
           +W  ++      R L  H + + +  FHP   E V +G  D+ I++W +  +      V 
Sbjct: 89  VW--DLEAAKILRTLMGHKANICSLDFHP-YGEFVASGSQDTNIKLWDIRRKG----CVF 141

Query: 739 QFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKEIKETEF 798
           ++  H   +  L F  +G  + S                   +H+V  W +      +EF
Sbjct: 142 RYRGHSQAVRCLRFSPDGKWLASAAD----------------DHTVKLWDLTAGKMMSEF 185

Query: 799 KGI--PISYLEIHPNGKRLLIHTKDSTLRIMDL-RILVARKFVGAANYREKIHSTL-TPC 854
            G   P++ +E HPN   L   + D T+R  DL +  V     G       + S L  P 
Sbjct: 186 PGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPG---PVRSVLFNPD 242

Query: 855 GTFLFAGSEDGI-VYVWNPE 873
           G  L++G +D + VY W PE
Sbjct: 243 GCCLYSGCQDSLRVYGWEPE 262



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 32/112 (28%), Positives = 57/112 (50%), Gaps = 13/112 (11%)

Query: 614 CLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSS 673
           CL FS +G+ LA+A    D + + L+++ +G+ M E  GH   +  + +  +++ + + S
Sbjct: 152 CLRFSPDGKWLASAA---DDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGS 208

Query: 674 SDGTARIWKNEINNTNTFRVLP----HPSFVYTAKFHPAVRELVVTGCYDSM 721
           SD T R W  E      F+V+      P  V +  F+P     + +GC DS+
Sbjct: 209 SDRTIRFWDLE-----KFQVVSCIEGEPGPVRSVLFNPD-GCCLYSGCQDSL 254


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 66/263 (25%), Positives = 113/263 (42%), Gaps = 26/263 (9%)

Query: 615 LDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSS 674
           + FS +G +LA+A  SRD    +      G+F  E   H   +  + +S D  ++ T+S 
Sbjct: 66  VQFSPHGNLLASA--SRDRTVRLWIPDKRGKFS-EFKAHTAPVRSVDFSADGQFLATASE 122

Query: 675 DGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSA 734
           D + ++W +       + +  H  +V  AKF P  R L+V+   D  I+IW    ++   
Sbjct: 123 DKSIKVW-SMYRQRFLYSLYRHTHWVRCAKFSPDGR-LIVSCSEDKTIKIWDTTNKQ--- 177

Query: 735 ILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKEIK 794
             V  F     F N + F+  G  + S      + VW+  V++N L   + H+ ++    
Sbjct: 178 -CVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD--VRVNKL---LQHYQVHSG-- 229

Query: 795 ETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGAANYREKIHSTLTPC 854
                   ++ +  HP+G  L+  + D TL+I+DL  L  R       +   + +     
Sbjct: 230 -------GVNCISFHPSGNYLITASSDGTLKILDL--LEGRLIYTLQGHTGPVFTVSFSK 280

Query: 855 GTFLFA-GSEDGIVYVWNPETGE 876
           G  LFA G  D  V +W     E
Sbjct: 281 GGELFASGGADTQVLLWRTNFDE 303



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 38/184 (20%), Positives = 76/184 (41%), Gaps = 37/184 (20%)

Query: 732 DSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWN--------TYVKINDL--- 780
           +  +L R F  HK+ I SL     G  + +      +++WN         YV   D+   
Sbjct: 6   EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTS 65

Query: 781 ---------------EHSVHHWTINKEIKETEFKG--IPISYLEIHPNGKRLLIHTKDST 823
                          + +V  W  +K  K +EFK    P+  ++   +G+ L   ++D +
Sbjct: 66  VQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKS 125

Query: 824 LRIMDLRILVARKFVGAANYREKIH----STLTPCGTFLFAGSEDGIVYVWNPETGEQVA 879
           +++     +  ++F+ +  YR   H    +  +P G  + + SED  + +W+    + V 
Sbjct: 126 IKVWS---MYRQRFLYSL-YRH-THWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180

Query: 880 MYSD 883
            +SD
Sbjct: 181 NFSD 184


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 68/271 (25%), Positives = 116/271 (42%), Gaps = 42/271 (15%)

Query: 638 LYEIPSGRFMRELCGHLNIIYDLSWSKD-DHYILTSSSDGTARIWKNEINNT-NTFRVLP 695
           L++  SG  +  L GH N++Y ++++      I T S D T ++W  E     +TFR   
Sbjct: 118 LWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFR--G 175

Query: 696 HPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTE 755
           H + +    F+P    LV TG  D+  ++W ++  E+    V     H + I SL F+T 
Sbjct: 176 HTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQNGEE----VYTLRGHSAEIISLSFNTS 230

Query: 756 GHHMYSGDCTGVIVVW--NTYVKIN-------DLEHSVHHW--------TINKEIKETE- 797
           G  + +G     +VVW  +T  K+N       ++  +  +W        +++K  K  + 
Sbjct: 231 GDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDA 290

Query: 798 FKGIPISYLEIHPN----------GKRLLIHTKDSTLRIMDLRILVARKFVGAANYREKI 847
             G  ++ L  H +          GK +   + D T RI        RK +      E  
Sbjct: 291 TNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS---AATRKCIAKLEGHEGE 347

Query: 848 HSTLT--PCGTFLFAGSEDGIVYVWNPETGE 876
            S ++  P G  L  GS D    +W+ +TG+
Sbjct: 348 ISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 61/266 (22%), Positives = 100/266 (37%), Gaps = 42/266 (15%)

Query: 614 CLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSS 673
           CL F+    ++A            L++I +G  +  L GH   I  LS++     I+T S
Sbjct: 182 CLSFNPQSTLVATGSMDTTAK---LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGS 238

Query: 674 SDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDS 733
            D T  +W  +        ++ H + + +A F+     L++TG  D   ++W     +  
Sbjct: 239 FDHTVVVWDADTGRKVNI-LIGHCAEISSASFNWDC-SLILTGSMDKTCKLWDATNGKCV 296

Query: 734 AILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKEI 793
           A L      H   I   CFD  G  + +    G   +++   +              K I
Sbjct: 297 ATLTG----HDDEILDSCFDYTGKLIATASADGTARIFSAATR--------------KCI 338

Query: 794 KETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMD------LRILVARK---FVGAANYR 844
            + E     IS +  +P G  LL  + D T RI D      L++L       F  A NY+
Sbjct: 339 AKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYK 398

Query: 845 EKIHSTLTPCGTFLFAGSEDGIVYVW 870
                     G  +  GS+D    +W
Sbjct: 399 ----------GNIVITGSKDNTCRIW 414



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 37/174 (21%), Positives = 78/174 (44%), Gaps = 11/174 (6%)

Query: 600 KHLFSLNAGERGCFCLDFSHNG-RILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIY 658
           + +++L         L F+ +G RI+  +      + +++++  +GR +  L GH   I 
Sbjct: 210 EEVYTLRGHSAEIISLSFNTSGDRIITGSF----DHTVVVWDADTGRKVNILIGHCAEIS 265

Query: 659 DLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCY 718
             S++ D   ILT S D T ++W +  N      +  H   +  + F     +L+ T   
Sbjct: 266 SASFNWDCSLILTGSMDKTCKLW-DATNGKCVATLTGHDDEILDSCF-DYTGKLIATASA 323

Query: 719 DSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWN 772
           D   RI+    R+     + + + H+  I+ + F+ +G+H+ +G       +W+
Sbjct: 324 DGTARIFSAATRK----CIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 34/111 (30%), Positives = 59/111 (53%), Gaps = 7/111 (6%)

Query: 617 FSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDG 676
           F + G+++A A A  DG   I +   + + + +L GH   I  +S++   +++LT SSD 
Sbjct: 311 FDYTGKLIATASA--DGTARI-FSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDK 367

Query: 677 TARIWKNEINNTNTFRVLP-HPSFVYTAKFHPAVRELVVTGCYDSMIRIWK 726
           TARIW  +       +VL  H   +++  F+     +V+TG  D+  RIW+
Sbjct: 368 TARIW--DAQTGQCLQVLEGHTDEIFSCAFNYK-GNIVITGSKDNTCRIWR 415


>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
           sapiens]
          Length = 340

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 63/272 (23%), Positives = 115/272 (42%), Gaps = 42/272 (15%)

Query: 645 RFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLP-HPSFVYTA 703
           R  R L GHL  IY + W+ D   ++++S DG   +W  +   TN    +P   S+V T 
Sbjct: 46  RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVW--DSYTTNKVHAIPLRSSWVMTC 103

Query: 704 KFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHM---- 759
            + P+    V  G  D+M  I+ ++ RE +  + R+   H  +++   F  + + +    
Sbjct: 104 AYAPS-GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSG 162

Query: 760 --------------------YSGDCTGVIVV--WNTYVKINDLEHSVHHWTINKEIKETE 797
                               ++GDC  + V   +N ++     + S   W + +      
Sbjct: 163 DTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFIS-GACDASAKLWDVREGTCRQT 221

Query: 798 FKG--IPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGAANYREKIHSTLTP-- 853
           F G    I+ +   PNG+ +   + D++ R+ DLR    ++ +  ++  E I   +T   
Sbjct: 222 FTGHESDINAICFFPNGEAICTGSDDASCRLFDLR--ADQELICFSH--ESIICGITSVA 277

Query: 854 ---CGTFLFAGSEDGIVYVWNPETGEQVAMYS 882
               G  LFAG +D    VW+    E+V + S
Sbjct: 278 FSLSGRLLFAGYDDFNCNVWDSMKSERVGILS 309



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 30/126 (23%), Positives = 56/126 (44%), Gaps = 6/126 (4%)

Query: 638 LYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWK-NEINNTNTFRVLPH 696
           L++I +G+      GH      L+ S D +  ++ + D +A++W   E     TF    H
Sbjct: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTF--TGH 225

Query: 697 PSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEG 756
            S +    F P   E + TG  D+  R++  ++R D  ++    +     I S+ F   G
Sbjct: 226 ESDINAICFFPN-GEAICTGSDDASCRLF--DLRADQELICFSHESIICGITSVAFSLSG 282

Query: 757 HHMYSG 762
             +++G
Sbjct: 283 RLLFAG 288


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 54/232 (23%), Positives = 91/232 (39%), Gaps = 23/232 (9%)

Query: 598 PNKHLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNII 657
           P    +     +    C++FS +G +LA+   SRD    I      G        H   +
Sbjct: 12  PQSRAYRFTGHKDAVTCVNFSPSGHLLASG--SRDKTVRIWVPNVKGE-STVFRAHTATV 68

Query: 658 YDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGC 717
             + +  D    +T+S D T ++W         F +  H ++V  AKF P  R L+V+  
Sbjct: 69  RSVHFCSDGQSFVTASDDKTVKVWATH-RQKFLFSLSQHINWVRCAKFSPDGR-LIVSAS 126

Query: 718 YDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKI 777
            D  +++W    RE     V  +  H  F+  + F   G  + +      + VW+     
Sbjct: 127 DDKTVKLWDKSSRE----CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR 182

Query: 778 NDLEHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDL 829
               + +H   +N               L  HP+G  L+  + DSTL+I+DL
Sbjct: 183 LLQHYQLHSAAVNG--------------LSFHPSGNYLITASSDSTLKILDL 220



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 56/285 (19%), Positives = 114/285 (40%), Gaps = 34/285 (11%)

Query: 642 PSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKNEINNTNT-FRVLPHPSFV 700
           P  R  R   GH + +  +++S   H + + S D T RIW   +   +T FR   H + V
Sbjct: 12  PQSRAYR-FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRA--HTATV 68

Query: 701 YTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMY 760
            +  F    +  V T   D  +++W    ++     +     H +++    F  +G  + 
Sbjct: 69  RSVHFCSDGQSFV-TASDDKTVKVWATHRQK----FLFSLSQHINWVRCAKFSPDGRLIV 123

Query: 761 SGDCTGVIVVWNTYVKINDLEHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTK 820
           S      + +W+           VH +         E  G  ++Y++ HP+G  +     
Sbjct: 124 SASDDKTVKLWD-----KSSRECVHSYC--------EHGGF-VTYVDFHPSGTCIAAAGM 169

Query: 821 DSTLRIMDL---RILVARKFVGAANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQ 877
           D+T+++ D+   R+L   +   AA      H    P G +L   S D  + + +   G  
Sbjct: 170 DNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH----PSGNYLITASSDSTLKILDLMEGR- 224

Query: 878 VAMYSDLPFKSPIRDISYHPFENMVAFCAFGQNEPILLYIYDFHV 922
             +Y+    + P   +++        F + G +E ++++  +F +
Sbjct: 225 -LLYTLHGHQGPATTVAFS--RTGEYFASGGSDEQVMVWKSNFDI 266


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 54/232 (23%), Positives = 91/232 (39%), Gaps = 23/232 (9%)

Query: 598 PNKHLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNII 657
           P    +     +    C++FS +G +LA+   SRD    I      G        H   +
Sbjct: 50  PQSRAYRFTGHKDAVTCVNFSPSGHLLASG--SRDKTVRIWVPNVKGE-STVFRAHTATV 106

Query: 658 YDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGC 717
             + +  D    +T+S D T ++W         F +  H ++V  AKF P  R L+V+  
Sbjct: 107 RSVHFCSDGQSFVTASDDKTVKVWATH-RQKFLFSLSQHINWVRCAKFSPDGR-LIVSAS 164

Query: 718 YDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKI 777
            D  +++W    RE     V  +  H  F+  + F   G  + +      + VW+     
Sbjct: 165 DDKTVKLWDKSSRE----CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR 220

Query: 778 NDLEHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDL 829
               + +H   +N               L  HP+G  L+  + DSTL+I+DL
Sbjct: 221 LLQHYQLHSAAVNG--------------LSFHPSGNYLITASSDSTLKILDL 258



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 65/313 (20%), Positives = 129/313 (41%), Gaps = 36/313 (11%)

Query: 614 CLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSS 673
           C+DFS N + LA+   S D   ++ +  P  R  R   GH + +  +++S   H + + S
Sbjct: 24  CVDFSINTKQLASG--SMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHLLASGS 80

Query: 674 SDGTARIWKNEINNTNT-FRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMRED 732
            D T RIW   +   +T FR   H + V +  F    +  V T   D  +++W    ++ 
Sbjct: 81  RDKTVRIWVPNVKGESTVFRA--HTATVRSVHFCSDGQSFV-TASDDKTVKVWATHRQK- 136

Query: 733 SAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKE 792
               +     H +++    F  +G  + S      + +W+           VH +     
Sbjct: 137 ---FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD-----KSSRECVHSYC---- 184

Query: 793 IKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDL---RILVARKFVGAANYREKIHS 849
               E  G  ++Y++ HP+G  +     D+T+++ D+   R+L   +   AA      H 
Sbjct: 185 ----EHGGF-VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH- 238

Query: 850 TLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFENMVAFCAFGQ 909
              P G +L   S D  + + +   G    +Y+    + P   +++        F + G 
Sbjct: 239 ---PSGNYLITASSDSTLKILDLMEGR--LLYTLHGHQGPATTVAFS--RTGEYFASGGS 291

Query: 910 NEPILLYIYDFHV 922
           +E ++++  +F +
Sbjct: 292 DEQVMVWKSNFDI 304


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 54/232 (23%), Positives = 91/232 (39%), Gaps = 23/232 (9%)

Query: 598 PNKHLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNII 657
           P    +     +    C++FS +G +LA+   SRD    I      G        H   +
Sbjct: 50  PQSRAYRFTGHKDAVTCVNFSPSGHLLASG--SRDKTVRIWVPNVKGE-STVFRAHTATV 106

Query: 658 YDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGC 717
             + +  D    +T+S D T ++W         F +  H ++V  AKF P  R L+V+  
Sbjct: 107 RSVHFCSDGQSFVTASDDKTVKVWATH-RQKFLFSLSQHINWVRCAKFSPDGR-LIVSAS 164

Query: 718 YDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKI 777
            D  +++W    RE     V  +  H  F+  + F   G  + +      + VW+     
Sbjct: 165 DDKTVKLWDKSSRE----CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR 220

Query: 778 NDLEHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDL 829
               + +H   +N               L  HP+G  L+  + DSTL+I+DL
Sbjct: 221 LLQHYQLHSAAVNG--------------LSFHPSGNYLITASSDSTLKILDL 258



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 65/313 (20%), Positives = 129/313 (41%), Gaps = 36/313 (11%)

Query: 614 CLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSS 673
           C+DFS N + LA+   S D   ++ +  P  R  R   GH + +  +++S   H + + S
Sbjct: 24  CVDFSINTKQLASG--SMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHLLASGS 80

Query: 674 SDGTARIWKNEINNTNT-FRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMRED 732
            D T RIW   +   +T FR   H + V +  F    +  V T   D  +++W    ++ 
Sbjct: 81  RDKTVRIWVPNVKGESTVFRA--HTATVRSVHFCSDGQSFV-TASDDKTVKVWATHRQK- 136

Query: 733 SAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKE 792
               +     H +++    F  +G  + S      + +W+           VH +     
Sbjct: 137 ---FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD-----KSSRECVHSYC---- 184

Query: 793 IKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDL---RILVARKFVGAANYREKIHS 849
               E  G  ++Y++ HP+G  +     D+T+++ D+   R+L   +   AA      H 
Sbjct: 185 ----EHGGF-VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH- 238

Query: 850 TLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFENMVAFCAFGQ 909
              P G +L   S D  + + +   G    +Y+    + P   +++        F + G 
Sbjct: 239 ---PSGNYLITASSDSTLKILDLMEGR--LLYTLHGHQGPATTVAFS--RTGEYFASGGS 291

Query: 910 NEPILLYIYDFHV 922
           +E ++++  +F +
Sbjct: 292 DEQVMVWKSNFDI 304


>gi|53759148 retinoblastoma binding protein 5 [Homo sapiens]
          Length = 538

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 66/303 (21%), Positives = 126/303 (41%), Gaps = 29/303 (9%)

Query: 617 FSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDG 676
           F+  G +LA  C   DG  I++++  +    + +  H++ +  L WS+D H ++++S+D 
Sbjct: 32  FNRWGTLLAVGC--NDGR-IVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDN 88

Query: 677 TARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAIL 736
               W  ++ + +  +    PS +   ++HP  +  V+     S   +  +    DS  +
Sbjct: 89  IVSQW--DVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTL---SDSKHV 143

Query: 737 VRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKEIKET 796
           V   D          FD  G ++Y+G+  G I+V  T     D +  V  + +      T
Sbjct: 144 VLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKT-----DSQDLVASFRVTTGTSNT 198

Query: 797 EFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGAANYREKIHSTL--TPC 854
                 I  +E    G   LI+T D  +R+ D R ++     G     +K+   +  TP 
Sbjct: 199 ----TAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPW 254

Query: 855 GTFLFAGSEDGIV---------YVWNPETGEQVAMYSDLPFKSPIRDISYHPFENMVAFC 905
               F+G  + IV         Y+W    G  V +      +  + D+++HP   ++A  
Sbjct: 255 KKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGEL-LLDVAWHPVRPIIASI 313

Query: 906 AFG 908
           + G
Sbjct: 314 SSG 316



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 31/113 (27%), Positives = 47/113 (41%), Gaps = 14/113 (12%)

Query: 812 GKRLLIHTKDSTLRIMDLRILVARKFVGAANYREKIHSTLTPC----GTFLFAGSEDGIV 867
           G  L +   D  + I D       K + A      IH   + C    G  L + S D IV
Sbjct: 36  GTLLAVGCNDGRIVIWDFLTRGIAKIISA-----HIHPVCSLCWSRDGHKLVSASTDNIV 90

Query: 868 YVWNPETGEQVAMYSDLPFKSPIRDISYHP-FENMVAFCAFGQNEPILLYIYD 919
             W+  +G+    +    F SPI  + YHP  +N V  C   ++ P++L + D
Sbjct: 91  SQWDVLSGDCDQRFR---FPSPILKVQYHPRDQNKVLVCPM-KSAPVMLTLSD 139


>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
           sapiens]
          Length = 315

 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 69/290 (23%), Positives = 123/290 (42%), Gaps = 42/290 (14%)

Query: 640 EIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSF 699
           E+P  R     CG    +  + ++ D +Y LT  SD T ++W N +  T       H   
Sbjct: 12  ELPQKRLKTLDCGQ-GAVRAVRFNVDGNYCLTCGSDKTLKLW-NPLRGTLLRTYSGHGYE 69

Query: 700 VYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHM 759
           V  A         + +G  D  + +W V     S  +VR+F  H   +N++ F+ E   +
Sbjct: 70  VLDAA-GSFDNSSLCSGGGDKAVVLWDVA----SGQVVRKFRGHAGKVNTVQFNEEATVI 124

Query: 760 YSGDCTGVIVVWN-------------------TYVKINDLEHSVHHWTINKEIKE----- 795
            SG     I  W+                   + VK++D  H +   +++  ++      
Sbjct: 125 LSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSD--HEILAGSVDGRVRRYDLRM 182

Query: 796 ----TEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRI-LVARKFVGAANYREKIHST 850
               +++ G PI+      +G+  L+ + DSTLR++D     +  ++ G  N   K+   
Sbjct: 183 GQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCC 242

Query: 851 LTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKS-PIRDISYHPFE 899
           L+   T + + SEDG V+ W+   G   A+   LP  S  ++ ++YHP E
Sbjct: 243 LSERDTHVVSCSEDGKVFFWDLVEG---ALALALPVGSGVVQSLAYHPTE 289



 Score = 34.3 bits (77), Expect = 0.73
 Identities = 13/57 (22%), Positives = 32/57 (56%)

Query: 625 AAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIW 681
           ++ C+      ++L+++ SG+ +R+  GH   +  + ++++   IL+ S D + R W
Sbjct: 80  SSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCW 136


>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
           sapiens]
          Length = 315

 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 69/290 (23%), Positives = 123/290 (42%), Gaps = 42/290 (14%)

Query: 640 EIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSF 699
           E+P  R     CG    +  + ++ D +Y LT  SD T ++W N +  T       H   
Sbjct: 12  ELPQKRLKTLDCGQ-GAVRAVRFNVDGNYCLTCGSDKTLKLW-NPLRGTLLRTYSGHGYE 69

Query: 700 VYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHM 759
           V  A         + +G  D  + +W V     S  +VR+F  H   +N++ F+ E   +
Sbjct: 70  VLDAA-GSFDNSSLCSGGGDKAVVLWDVA----SGQVVRKFRGHAGKVNTVQFNEEATVI 124

Query: 760 YSGDCTGVIVVWN-------------------TYVKINDLEHSVHHWTINKEIKE----- 795
            SG     I  W+                   + VK++D  H +   +++  ++      
Sbjct: 125 LSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSD--HEILAGSVDGRVRRYDLRM 182

Query: 796 ----TEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRI-LVARKFVGAANYREKIHST 850
               +++ G PI+      +G+  L+ + DSTLR++D     +  ++ G  N   K+   
Sbjct: 183 GQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCC 242

Query: 851 LTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKS-PIRDISYHPFE 899
           L+   T + + SEDG V+ W+   G   A+   LP  S  ++ ++YHP E
Sbjct: 243 LSERDTHVVSCSEDGKVFFWDLVEG---ALALALPVGSGVVQSLAYHPTE 289



 Score = 34.3 bits (77), Expect = 0.73
 Identities = 13/57 (22%), Positives = 32/57 (56%)

Query: 625 AAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIW 681
           ++ C+      ++L+++ SG+ +R+  GH   +  + ++++   IL+ S D + R W
Sbjct: 80  SSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCW 136


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 57/243 (23%), Positives = 103/243 (42%), Gaps = 28/243 (11%)

Query: 645 RFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLP-HPSFVYTA 703
           R  R L GHL  IY + W  D   ++++S DG   IW  +   TN    +P   S+V T 
Sbjct: 46  RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW--DSYTTNKVHAIPLRSSWVMTC 103

Query: 704 KFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCF-DTEGHHMYSG 762
            + P+    V  G  D++  I+ ++ RE +  + R+   H  +++   F D       SG
Sbjct: 104 AYAPS-GNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSG 162

Query: 763 DCTGVIVVWNTYVKINDLEHSVHHWTINKEIKETEFKGI--PISYLEIHPNGKRLLIHTK 820
           D T  +                  W I    +   F G    +  L + P+G+  +    
Sbjct: 163 DTTCAL------------------WDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGAC 204

Query: 821 DSTLRIMDLRILVARK-FVGAANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVA 879
           D+++++ D+R  + R+ F+G  +    +     P G     GS+D    +++    +++ 
Sbjct: 205 DASIKLWDVRDSMCRQTFIGHESDINAV--AFFPNGYAFTTGSDDATCRLFDLRADQELL 262

Query: 880 MYS 882
           MYS
Sbjct: 263 MYS 265



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 29/126 (23%), Positives = 54/126 (42%), Gaps = 6/126 (4%)

Query: 638 LYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWK-NEINNTNTFRVLPH 696
           L++I +G+      GH   +  LS + D    ++ + D + ++W   +     TF  + H
Sbjct: 168 LWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTF--IGH 225

Query: 697 PSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEG 756
            S +    F P       TG  D+  R++  ++R D  +L+   D     I S+ F   G
Sbjct: 226 ESDINAVAFFPN-GYAFTTGSDDATCRLF--DLRADQELLMYSHDNIICGITSVAFSRSG 282

Query: 757 HHMYSG 762
             + +G
Sbjct: 283 RLLLAG 288


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 27/55 (49%), Positives = 35/55 (63%), Gaps = 1/55 (1%)

Query: 1056 VVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPANHVASET 1110
            V+A+YDY AN  DEL+  +G +I V  KD+ DWW G I  G  G FP+N+V   T
Sbjct: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEI-NGVTGLFPSNYVKMTT 1158



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 34/121 (28%), Positives = 54/121 (44%), Gaps = 12/121 (9%)

Query: 1040 SIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEG 1099
            ++ +KP +         +ALY Y++    +LT   G+ I V  KD E WW GSIG  + G
Sbjct: 943  AVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIG-DRSG 1000

Query: 1100 YFPANHV----------ASETLYQELPPEIKERSPPLSPEEKTKIEKSPAPQKQSINKNK 1149
             FP+N+V          AS++      PEI + +         ++  +P      + KN 
Sbjct: 1001 IFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNT 1060

Query: 1150 S 1150
            S
Sbjct: 1061 S 1061



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 20/130 (15%)

Query: 1051 DTAPTVV---ALYDYTANRSDELTIHRGDIIRVFFK--DNEDWWYGSIGKGQEGYFPANH 1105
            +TA  +V   ALY + A   DE++ + GDII+V  K      W YGS  +G  G+FP N+
Sbjct: 727  ETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF-QGNFGWFPCNY 785

Query: 1106 VASETLYQELPPEIKERS--------PPLSPEEKTKIEKSPAPQKQSINKNKSQDFRLGS 1157
            V      +++P    E++        PP      T     P    Q  +    Q+    +
Sbjct: 786  V------EKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSN 839

Query: 1158 ESMTHSEMRK 1167
             ++  S  +K
Sbjct: 840  LTVNTSWQKK 849



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 22/71 (30%), Positives = 37/71 (52%), Gaps = 10/71 (14%)

Query: 1062 YTANRSDELTIHRGDIIRVFFKDNEDWWYGSI----GKGQEGYFPANHVASETLYQELPP 1117
            Y A+ S++L++  G +I +  K+   WW G +     K Q+G+FPA+HV      + L P
Sbjct: 1037 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV------KLLGP 1090

Query: 1118 EIKERSPPLSP 1128
              +  +P   P
Sbjct: 1091 SSERATPAFHP 1101



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 38/159 (23%), Positives = 66/159 (41%), Gaps = 17/159 (10%)

Query: 959  GSFQID------EFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQ 1012
            GSFQ +       +V    SS   + V  +   +   +   A   +     ++ PA  + 
Sbjct: 772  GSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTD 831

Query: 1013 QSKLKQSNMLTAQEILHQFGFTQT---GIISIERKPCNHQVDTAPTVVA--LYDYTANRS 1067
               +  SN+        +  FT+T   G +S    P + Q      + A  L  +TA + 
Sbjct: 832  YQNVSFSNLTVNTSWQKKSAFTRTVSPGSVS----PIHGQGQVVENLKAQALCSWTAKKD 887

Query: 1068 DELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPANHV 1106
            + L   + DII V  +  E+WW+G +  G  G+FP ++V
Sbjct: 888  NHLNFSKHDIITV-LEQQENWWFGEV-HGGRGWFPKSYV 924



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 40/205 (19%), Positives = 90/205 (43%), Gaps = 12/205 (5%)

Query: 26  LMREKKKLKKKLVRSEENISPDTIRSNLHYMKETTSDDPDTIRSNLPHIKETTSDDVSAA 85
           L+ EK+ L +++   + + +PD+  S LH       +    ++  L  +++ T+  +S  
Sbjct: 554 LVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEM 613

Query: 86  NT-NNLKKSTRVTKNKLRNTQLATENPNGDASVEEDKQGKPNKKVIKTVPQLTTQDLKPE 144
           ++ NN  K  R T N     QLA E       ++ DK  +  +K ++ + +   +D    
Sbjct: 614 DSFNNQLKELRETYN---TQQLALEQL---YKIKRDKLKEIERKRLELMQKKKLEDEAAR 667

Query: 145 TPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREETDLEEDEELMQAYQCHVTEEM-AKE 203
             +   ++  ++   K     + +K ++  E + +  ++E+E   +  Q    + + A+E
Sbjct: 668 KAKQGKENLWKENLRKE----EEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEE 723

Query: 204 IKRKIRKKLKEQLTYFPSDTLFHDD 228
            KR+    L      +P +   HD+
Sbjct: 724 KKRETASVLVNYRALYPFEARNHDE 748


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 27/55 (49%), Positives = 35/55 (63%), Gaps = 1/55 (1%)

Query: 1056 VVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPANHVASET 1110
            V+A+YDY AN  DEL+  +G +I V  KD+ DWW G I  G  G FP+N+V   T
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEI-NGVTGLFPSNYVKMTT 1185



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 34/121 (28%), Positives = 54/121 (44%), Gaps = 12/121 (9%)

Query: 1040 SIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEG 1099
            ++ +KP +         +ALY Y++    +LT   G+ I V  KD E WW GSIG  + G
Sbjct: 970  AVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIG-DRSG 1027

Query: 1100 YFPANHV----------ASETLYQELPPEIKERSPPLSPEEKTKIEKSPAPQKQSINKNK 1149
             FP+N+V          AS++      PEI + +         ++  +P      + KN 
Sbjct: 1028 IFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNT 1087

Query: 1150 S 1150
            S
Sbjct: 1088 S 1088



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 20/130 (15%)

Query: 1051 DTAPTVV---ALYDYTANRSDELTIHRGDIIRVFFK--DNEDWWYGSIGKGQEGYFPANH 1105
            +TA  +V   ALY + A   DE++ + GDII+V  K      W YGS  +G  G+FP N+
Sbjct: 754  ETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF-QGNFGWFPCNY 812

Query: 1106 VASETLYQELPPEIKERS--------PPLSPEEKTKIEKSPAPQKQSINKNKSQDFRLGS 1157
            V      +++P    E++        PP      T     P    Q  +    Q+    +
Sbjct: 813  V------EKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSN 866

Query: 1158 ESMTHSEMRK 1167
             ++  S  +K
Sbjct: 867  LTVNTSWQKK 876



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 22/71 (30%), Positives = 37/71 (52%), Gaps = 10/71 (14%)

Query: 1062 YTANRSDELTIHRGDIIRVFFKDNEDWWYGSI----GKGQEGYFPANHVASETLYQELPP 1117
            Y A+ S++L++  G +I +  K+   WW G +     K Q+G+FPA+HV      + L P
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV------KLLGP 1117

Query: 1118 EIKERSPPLSP 1128
              +  +P   P
Sbjct: 1118 SSERATPAFHP 1128



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 38/159 (23%), Positives = 66/159 (41%), Gaps = 17/159 (10%)

Query: 959  GSFQID------EFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQ 1012
            GSFQ +       +V    SS   + V  +   +   +   A   +     ++ PA  + 
Sbjct: 799  GSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTD 858

Query: 1013 QSKLKQSNMLTAQEILHQFGFTQT---GIISIERKPCNHQVDTAPTVVA--LYDYTANRS 1067
               +  SN+        +  FT+T   G +S    P + Q      + A  L  +TA + 
Sbjct: 859  YQNVSFSNLTVNTSWQKKSAFTRTVSPGSVS----PIHGQGQVVENLKAQALCSWTAKKD 914

Query: 1068 DELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPANHV 1106
            + L   + DII V  +  E+WW+G +  G  G+FP ++V
Sbjct: 915  NHLNFSKHDIITV-LEQQENWWFGEV-HGGRGWFPKSYV 951


>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
          Length = 1249

 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 27/55 (49%), Positives = 35/55 (63%), Gaps = 1/55 (1%)

Query: 1056 VVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPANHVASET 1110
            V+A+YDY AN  DEL+  +G +I V  KD+ DWW G I  G  G FP+N+V   T
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEI-NGVTGLFPSNYVKMTT 1185



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 34/121 (28%), Positives = 54/121 (44%), Gaps = 12/121 (9%)

Query: 1040 SIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEG 1099
            ++ +KP +         +ALY Y++    +LT   G+ I V  KD E WW GSIG  + G
Sbjct: 970  AVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIG-DRSG 1027

Query: 1100 YFPANHV----------ASETLYQELPPEIKERSPPLSPEEKTKIEKSPAPQKQSINKNK 1149
             FP+N+V          AS++      PEI + +         ++  +P      + KN 
Sbjct: 1028 IFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNT 1087

Query: 1150 S 1150
            S
Sbjct: 1088 S 1088



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 20/130 (15%)

Query: 1051 DTAPTVV---ALYDYTANRSDELTIHRGDIIRVFFK--DNEDWWYGSIGKGQEGYFPANH 1105
            +TA  +V   ALY + A   DE++ + GDII+V  K      W YGS  +G  G+FP N+
Sbjct: 754  ETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF-QGNFGWFPCNY 812

Query: 1106 VASETLYQELPPEIKERS--------PPLSPEEKTKIEKSPAPQKQSINKNKSQDFRLGS 1157
            V      +++P    E++        PP      T     P    Q  +    Q+    +
Sbjct: 813  V------EKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSN 866

Query: 1158 ESMTHSEMRK 1167
             ++  S  +K
Sbjct: 867  LTVNTSWQKK 876



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 22/71 (30%), Positives = 37/71 (52%), Gaps = 10/71 (14%)

Query: 1062 YTANRSDELTIHRGDIIRVFFKDNEDWWYGSI----GKGQEGYFPANHVASETLYQELPP 1117
            Y A+ S++L++  G +I +  K+   WW G +     K Q+G+FPA+HV      + L P
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV------KLLGP 1117

Query: 1118 EIKERSPPLSP 1128
              +  +P   P
Sbjct: 1118 SSERATPAFHP 1128



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 38/159 (23%), Positives = 66/159 (41%), Gaps = 17/159 (10%)

Query: 959  GSFQID------EFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQ 1012
            GSFQ +       +V    SS   + V  +   +   +   A   +     ++ PA  + 
Sbjct: 799  GSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTD 858

Query: 1013 QSKLKQSNMLTAQEILHQFGFTQT---GIISIERKPCNHQVDTAPTVVA--LYDYTANRS 1067
               +  SN+        +  FT+T   G +S    P + Q      + A  L  +TA + 
Sbjct: 859  YQNVSFSNLTVNTSWQKKSAFTRTVSPGSVS----PIHGQGQVVENLKAQALCSWTAKKD 914

Query: 1068 DELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPANHV 1106
            + L   + DII V  +  E+WW+G +  G  G+FP ++V
Sbjct: 915  NHLNFSKHDIITV-LEQQENWWFGEV-HGGRGWFPKSYV 951


>gi|5174447 guanine nucleotide binding protein (G protein), beta
           polypeptide 2-like 1 [Homo sapiens]
          Length = 317

 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 69/311 (22%), Positives = 124/311 (39%), Gaps = 50/311 (16%)

Query: 582 KEVIKWKR--------LPGQACRIPNKHLFSLNAGERGCFCLDFSHNGRILAAACASRDG 633
           K +I WK         +P +A R  +  +  +     G F L  S +G +          
Sbjct: 38  KTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR--------- 88

Query: 634 YPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRV 693
               L+++ +G   R   GH   +  +++S D+  I++ S D T ++W        T + 
Sbjct: 89  ----LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQD 144

Query: 694 LPHPSFVYTAKFHPAVRELVVTGC-YDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCF 752
             H  +V   +F P     ++  C +D ++++W +     +  L      H  ++N++  
Sbjct: 145 ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA----NCKLKTNHIGHTGYLNTVTV 200

Query: 753 DTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKEIKETEFKGIPISYLEIHPNG 812
             +G    SG   G  ++W       DL    H +T++         G  I+ L   PN 
Sbjct: 201 SPDGSLCASGGKDGQAMLW-------DLNEGKHLYTLD--------GGDIINALCFSPNR 245

Query: 813 KRLLIHTKDSTLRIMDL--RILV---ARKFVGAANYREKIHST---LTPCGTFLFAGSED 864
             L   T  S ++I DL  +I+V    ++ +  ++  E    T    +  G  LFAG  D
Sbjct: 246 YWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTD 304

Query: 865 GIVYVWNPETG 875
            +V VW    G
Sbjct: 305 NLVRVWQVTIG 315



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 47/216 (21%), Positives = 92/216 (42%), Gaps = 25/216 (11%)

Query: 669 ILTSSSDGTARIWKNEINNTN---TFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIW 725
           IL++S D T  +WK   + TN     R L   S   +     +  +  ++G +D  +R+W
Sbjct: 31  ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90

Query: 726 KVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVH 785
            +     +    R+F  H   + S+ F ++   + SG     I +WNT          V 
Sbjct: 91  DLT----TGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL--------GVC 138

Query: 786 HWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTK--DSTLRIMDL-RILVARKFVGAAN 842
            +T+  E   +E+    +S +   PN    +I +   D  +++ +L    +    +G   
Sbjct: 139 KYTVQDE-SHSEW----VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTG 193

Query: 843 YREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQV 878
           Y   +  T++P G+   +G +DG   +W+   G+ +
Sbjct: 194 YLNTV--TVSPDGSLCASGGKDGQAMLWDLNEGKHL 227


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 26/55 (47%), Positives = 35/55 (63%), Gaps = 1/55 (1%)

Query: 1056 VVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPANHVASET 1110
            V+ +YDYTA   DEL  ++G II V  K++ DWW G +  GQ G FP+N+V   T
Sbjct: 1160 VIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV-NGQVGLFPSNYVKLTT 1213



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 8/90 (8%)

Query: 1058 ALYDYTANRSDELTIHRGDIIRV------FFKDNEDWWYGSIGKGQEGYFPANHVASETL 1111
            ALY + +   DE+TI  GDI+ V        +  E  W G   KG+ G+FPAN+ A +  
Sbjct: 747  ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANY-AEKIP 805

Query: 1112 YQELPPEIKERSPPLS-PEEKTKIEKSPAP 1140
              E+P  +K  +   S P  K  + ++PAP
Sbjct: 806  ENEVPAPVKPVTDSTSAPAPKLALRETPAP 835



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 23/62 (37%), Positives = 36/62 (58%), Gaps = 2/62 (3%)

Query: 1045 PCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPAN 1104
            P    V +    +A+Y Y ++   +LT  +GD+I V  KD  DWW G++G  + G FP+N
Sbjct: 996  PAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDG-DWWTGTVG-DKAGVFPSN 1053

Query: 1105 HV 1106
            +V
Sbjct: 1054 YV 1055



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 17/49 (34%), Positives = 32/49 (65%), Gaps = 2/49 (4%)

Query: 1058 ALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPANHV 1106
            ALY + A + + L  ++ D+I V  +  + WW+G + +GQ+G+FP ++V
Sbjct: 920  ALYPWRAKKDNHLNFNKNDVITVL-EQQDMWWFGEV-QGQKGWFPKSYV 966



 Score = 37.4 bits (85), Expect = 0.086
 Identities = 19/49 (38%), Positives = 28/49 (57%), Gaps = 4/49 (8%)

Query: 1062 YTANRSDELTIHRGDIIRVFFKDNEDWWYGSI----GKGQEGYFPANHV 1106
            YTA   ++LT+  G +I +  K+   WW G +     K Q G+FPAN+V
Sbjct: 1085 YTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYV 1133


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,011,668
Number of Sequences: 37866
Number of extensions: 2348493
Number of successful extensions: 11393
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 293
Number of HSP's successfully gapped in prelim test: 657
Number of HSP's that attempted gapping in prelim test: 8490
Number of HSP's gapped (non-prelim): 2940
length of query: 1196
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1082
effective length of database: 13,930,794
effective search space: 15073119108
effective search space used: 15073119108
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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