Guide to the Human Genome
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Search of human proteins with 19923597

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19923597 Sin3A-associated protein, 130kDa isoform b [Homo
sapiens]
         (1048 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19923597 Sin3A-associated protein, 130kDa isoform b [Homo sap...  2063   0.0  
gi|225579127 Sin3A-associated protein, 130kDa isoform a [Homo sa...  2046   0.0  
gi|91982772 mucin 17 [Homo sapiens]                                   125   2e-28
gi|116284392 mucin 2 precursor [Homo sapiens]                         120   5e-27
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                  116   1e-25
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                  116   1e-25
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                  116   1e-25
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                   116   1e-25
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   100   1e-20
gi|167736355 mucin 4 isoform a [Homo sapiens]                          97   1e-19
gi|239749951 PREDICTED: similar to mucin 2 [Homo sapiens]              96   1e-19
gi|151301154 mucin 6, gastric [Homo sapiens]                           96   2e-19
gi|163965366 nascent polypeptide-associated complex alpha subuni...    96   2e-19
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         92   2e-18
gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]       85   3e-16
gi|83367077 mucin 16 [Homo sapiens]                                    84   7e-16
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]        82   3e-15
gi|161019170 mucin 5AC [Homo sapiens]                                  80   1e-14
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    77   8e-14
gi|149773456 hypothetical protein LOC643314 [Homo sapiens]             74   6e-13
gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens]      74   6e-13
gi|148612879 polyhomeotic like 3 [Homo sapiens]                        74   6e-13
gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapi...    74   9e-13
gi|150378545 POM121 membrane glycoprotein (rat)-like [Homo sapiens]    74   9e-13
gi|171460948 TSC22 domain family, member 1 isoform 1 [Homo sapiens]    71   5e-12
gi|169205253 PREDICTED: hypothetical protein [Homo sapiens]            70   8e-12
gi|239752529 PREDICTED: similar to mucin [Homo sapiens]                69   2e-11
gi|56549668 AT rich interactive domain 2 (ARID, RFX-like) [Homo ...    69   2e-11
gi|239743291 PREDICTED: mucin 3A, intestinal [Homo sapiens]            69   2e-11
gi|222352122 hypothetical protein LOC284297 [Homo sapiens]             68   4e-11

>gi|19923597 Sin3A-associated protein, 130kDa isoform b [Homo sapiens]
          Length = 1048

 Score = 2063 bits (5346), Expect = 0.0
 Identities = 1048/1048 (100%), Positives = 1048/1048 (100%)

Query: 1    MGPPRHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINP 60
            MGPPRHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINP
Sbjct: 1    MGPPRHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINP 60

Query: 61   AATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVA 120
            AATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVA
Sbjct: 61   AATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVA 120

Query: 121  VTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSI 180
            VTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSI
Sbjct: 121  VTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSI 180

Query: 181  PQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVM 240
            PQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVM
Sbjct: 181  PQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVM 240

Query: 241  SSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQS 300
            SSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQS
Sbjct: 241  SSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQS 300

Query: 301  PVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQL 360
            PVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQL
Sbjct: 301  PVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQL 360

Query: 361  HTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHA 420
            HTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHA
Sbjct: 361  HTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHA 420

Query: 421  TAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPS 480
            TAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPS
Sbjct: 421  TAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPS 480

Query: 481  VPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTV 540
            VPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTV
Sbjct: 481  VPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTV 540

Query: 541  HLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQ 600
            HLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQ
Sbjct: 541  HLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQ 600

Query: 601  GLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAP 660
            GLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAP
Sbjct: 601  GLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAP 660

Query: 661  AQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQP 720
            AQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQP
Sbjct: 661  AQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQP 720

Query: 721  PPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVP 780
            PPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVP
Sbjct: 721  PPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVP 780

Query: 781  EIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQ 840
            EIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQ
Sbjct: 781  EIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQ 840

Query: 841  HVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLL 900
            HVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLL
Sbjct: 841  HVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLL 900

Query: 901  RHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTN 960
            RHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTN
Sbjct: 901  RHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTN 960

Query: 961  LEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVL 1020
            LEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVL
Sbjct: 961  LEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVL 1020

Query: 1021 DHKDRVLKLLNKNGTVKKVSKLKRKEKV 1048
            DHKDRVLKLLNKNGTVKKVSKLKRKEKV
Sbjct: 1021 DHKDRVLKLLNKNGTVKKVSKLKRKEKV 1048


>gi|225579127 Sin3A-associated protein, 130kDa isoform a [Homo
            sapiens]
          Length = 1083

 Score = 2046 bits (5300), Expect = 0.0
 Identities = 1048/1083 (96%), Positives = 1048/1083 (96%), Gaps = 35/1083 (3%)

Query: 1    MGPPRHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINP 60
            MGPPRHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINP
Sbjct: 1    MGPPRHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINP 60

Query: 61   AATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVA 120
            AATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVA
Sbjct: 61   AATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVA 120

Query: 121  VTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSI 180
            VTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSI
Sbjct: 121  VTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSI 180

Query: 181  PQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVM 240
            PQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVM
Sbjct: 181  PQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVM 240

Query: 241  SSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQS 300
            SSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQS
Sbjct: 241  SSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQS 300

Query: 301  PVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQL 360
            PVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQL
Sbjct: 301  PVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQL 360

Query: 361  HTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHA 420
            HTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHA
Sbjct: 361  HTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHA 420

Query: 421  TAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPS 480
            TAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPS
Sbjct: 421  TAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPS 480

Query: 481  VPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTV 540
            VPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTV
Sbjct: 481  VPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTV 540

Query: 541  HLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQ 600
            HLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQ
Sbjct: 541  HLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQ 600

Query: 601  GLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAP 660
            GLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAP
Sbjct: 601  GLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAP 660

Query: 661  AQGSSPRPSILRKKPATD-----------------------------------GAKPKSE 685
            AQGSSPRPSILRKKPATD                                   GAKPKSE
Sbjct: 661  AQGSSPRPSILRKKPATDGMAVRKTLIPPQPPDVASPRVESSMRSTSGSPRPAGAKPKSE 720

Query: 686  IHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIP 745
            IHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIP
Sbjct: 721  IHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIP 780

Query: 746  GAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLAT 805
            GAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLAT
Sbjct: 781  GAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLAT 840

Query: 806  NTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKS 865
            NTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKS
Sbjct: 841  NTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKS 900

Query: 866  LLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEE 925
            LLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEE
Sbjct: 901  LLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEE 960

Query: 926  KKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATD 985
            KKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATD
Sbjct: 961  KKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATD 1020

Query: 986  DDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRK 1045
            DDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRK
Sbjct: 1021 DDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRK 1080

Query: 1046 EKV 1048
            EKV
Sbjct: 1081 EKV 1083


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score =  125 bits (314), Expect = 2e-28
 Identities = 201/915 (21%), Positives = 346/915 (37%), Gaps = 107/915 (11%)

Query: 38   PSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQ--SREEKQEP 95
            P T +  + + +ANS ++ L       +      +E S+    +  +S++  +  +   P
Sbjct: 2693 PLTNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDGSTP 2752

Query: 96   VVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPL-SFSEGLMKPPPKPTMPSRPI 154
            +       + + S+  +  S T V  + P    T A    + +E    P   P+  S P+
Sbjct: 2753 LTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETSTPL 2812

Query: 155  APAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSII 214
               P +   +     G ++ T     P  ++ PV T +     P+    I+        I
Sbjct: 2813 TSMPVNHTPVASSEAGTLSTT-----PVDTSTPVTTSTKASSSPTTAEGIVVP------I 2861

Query: 215  RSNAPGPPL--HIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAA--TAQPAVQHIIH 270
             + + G  L   I  S  P  ++ A+ +S++ V T +  T+    ++  T        I 
Sbjct: 2862 STASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPIS 2921

Query: 271  QPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAI 330
             P +   P+T+       V  + ++T + +PV T T    +  A S PT +       ++
Sbjct: 2922 TPSEVSTPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTA----EGTSM 2977

Query: 331  SIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVA---PILATN 387
             I  P + R   T +++ + P   +    L     +T   T TPV  +T A   P  A  
Sbjct: 2978 PISTPGERRTPLTSMSVSTMPVASSEASTL----SRTPADTSTPVTTSTEASSSPTTAEG 3033

Query: 388  T-IPSATTA-GSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRI 445
            T IP +T + GS   T  P ST   + +P  S+ +T    SN PV       +T T    
Sbjct: 3034 TGIPISTPSEGSTPLTSIPVST-TPVAIPEASTLSTTPVDSNSPV-------VTSTEVSS 3085

Query: 446  QPDYPAERSSLIPISGHRASPNP---VAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAH 502
             P  PAE +S+ PIS +     P   V + T      ++       + T  P      AH
Sbjct: 3086 SPT-PAEGTSM-PISTYSEGSTPLTGVPVSTTPVTSSAISTLSTTPVDTSTPVTTSTEAH 3143

Query: 503  TYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVAS---TVHLNPMQLMT-----VDASH 554
            +    +   S     P     P + +   T + V+S   T+   P+   T      +A+ 
Sbjct: 3144 SSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATS 3203

Query: 555  ARHIQGIQ-PAPISTQGIQP---APIGTPGI---QPAPLGTQGIHSATPINTQ----GLQ 603
            +   +G   P    ++G+ P    P+    +   + + L T  + S TP+ T        
Sbjct: 3204 STTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSP 3263

Query: 604  PAPMGTQQPQP---EGKTSAVVLADGATIVANPISNPFSAAPAAT-TVVQTHSQSASTNA 659
            P   GT  P     EG T    +    T VA+  ++  S  PA T T V T+SQ++S+  
Sbjct: 3264 PTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPP 3323

Query: 660  PAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPT-AQ 718
             A G+S   S       ++G+ P + +  S    V+    T+S    D  T     T A 
Sbjct: 3324 IADGTSMPTSTY-----SEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEAS 3378

Query: 719  QPPPTIPTMIAAASPPSQPAVALSTIPGAVP--ITPPITTIAAAPPPSVTV-------GG 769
              P T        S PS+    L+++P +    ++  + T++  P  S T+         
Sbjct: 3379 LSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEASS 3438

Query: 770  SLSSVLGPPVPEIKVKEEVEPMDIM-----------------RPVSAVPPLATNTVSPSL 812
            S +   G  +P     E   P+ IM                  PV    P+ T++ + S 
Sbjct: 3439 SPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTNSS 3498

Query: 813  ALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTD--------DEKSTAK 864
               A   SMPTS    G++P          +++ E   + T   D         + S++ 
Sbjct: 3499 PTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSP 3558

Query: 865  SLLVKAEKRKSPPKE 879
            + L     R S P E
Sbjct: 3559 ATLQVTTMRMSTPSE 3573



 Score =  114 bits (286), Expect = 4e-25
 Identities = 196/916 (21%), Positives = 333/916 (36%), Gaps = 80/916 (8%)

Query: 38   PSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEK--QEP 95
            P T +  +  ++A+S +  L+     ++      ++ S+    +   SL +        P
Sbjct: 217  PLTSMPASTMKVASSEAITLLTTPVEISTPVTISAQASSSPTTAEGPSLSNSAPSGGSTP 276

Query: 96   VVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPL-SFSEGLMKPPPKPTMPSRPI 154
            +   P   + ++S+  +  S TP A   P    T A    + +EG   P    T  S P+
Sbjct: 277  LTRMPLSVMLVVSSEASTLSTTPAATNIPVITSTEASSSPTTAEGTSIPTSTYTEGSTPL 336

Query: 155  APAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSII 214
               P ST+ +          T E S    + +  +T+      PS+L         ++  
Sbjct: 337  TSTPASTMPV---------ATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTST 387

Query: 215  RSNAPGPPLHIGASHLPRGAAAAAVMSSSKVT--TVLRPTSQLPNAATAQPAVQHIIHQP 272
             S    P  ++  S +   ++ A+  S+  V   T +   S+  ++ T           P
Sbjct: 388  LSEGSTPLTNMPVSTILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTP 447

Query: 273  IQSRPPVTTSNAIPPAVVATVSATRAQSPVITTT-AAHATDSALSRPTLSIQHPPSAAIS 331
             +   P+T+       V ++ ++  + +PV + T    +T+++ S PT  +   P++  S
Sbjct: 448  SEGSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPS 507

Query: 332  -----------IQRPAQSRDVTTRITLP---SHPALGTPK-QQLHTMAQKTIFSTGTPVA 376
                          P  S + +T  T P   S P   + +     T  + T   T TP  
Sbjct: 508  EGSTPLTSMSVSTMPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSE 567

Query: 377  AATVAPILATNT-IPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVP 435
             +T    +  +T +  ++ A + S T A ++T VT +  + SS  TA  TS +P +    
Sbjct: 568  GSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTS-MPTSTYSE 626

Query: 436  QQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPS 495
            +  T TS  +     A   +    +    S  PV   T + +  +          TY   
Sbjct: 627  RGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEG 686

Query: 496  AYPLAA---HTYTPITSSVSTIRQYPVSAQAP----NSAITAQTGVGVASTVHLNPMQLM 548
            + PL +   +T    +S  ST+   PV    P      A ++ T    AS     P +  
Sbjct: 687  STPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGS 746

Query: 549  TVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMG 608
            T   S       +  +  ST    P    T       + T    S +P  T+G    P+ 
Sbjct: 747  TPLTSMPVSKTLLTSSEASTLSTTPLDTSTH------ITTSTEASCSPTTTEGTS-MPIS 799

Query: 609  TQQPQPEGKTSAVVLADGATIVANPISNPFSAAPA-ATTVVQTHSQSASTNAPAQGSSPR 667
            T     EG      +    T V +P ++  S  P  + + V T ++ +S+  PA+G+S  
Sbjct: 800  TPS---EGSPLLTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMP 856

Query: 668  PSI-------LRKKP------ATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVP 714
             S        L   P      AT      S   V  +TPVT S E  S+    + T ++P
Sbjct: 857  TSTYSEGRTPLTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGT-SMP 915

Query: 715  ---------PTAQQPPPTIPTMIAAASPPSQPAVALST-IPGAVPITPPITTIAAAPPPS 764
                     P    P  T P + + A   S   V  ST +  +   T   TT      P+
Sbjct: 916  TSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPT 975

Query: 765  VTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTS 824
             T     + +   PV    V           PV +  PL T+T + S    A   SMPTS
Sbjct: 976  STPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTS 1035

Query: 825  DLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEK-----STAKSLLVKAEKRKSPPKE 879
                G++P  +      ++++ E   + T   D        S A S    A+    P   
Sbjct: 1036 TPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGTSMPTST 1095

Query: 880  YID-EEGVRYVPVRPR 894
            Y +    +  VPV  R
Sbjct: 1096 YSEGSTPLTSVPVSTR 1111



 Score =  113 bits (283), Expect = 8e-25
 Identities = 200/860 (23%), Positives = 331/860 (38%), Gaps = 134/860 (15%)

Query: 95   PVVVRPY--PQVQMLST-----HHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKP 147
            PV   P   P+   LST     +  V ++T ++ +A  A  T     ++SEG     P  
Sbjct: 2521 PVSTTPVASPEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEG---STPLR 2577

Query: 148  TMP--SRPIAPAPPSTLSLPP-----------KVPGQVTVTMESSIPQASAIPVAT---- 190
            +MP  ++P+A +  STLS  P           +     T   ++S+P ++   V+T    
Sbjct: 2578 SMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTS 2637

Query: 191  --ISGQQGHPSNLHHIMTTNVQMSIIRSNAPGP---PLHIGASHLPRGAAAAAVMSSSKV 245
              +S      S    + TT V    + + + G    P     S +P          S+ +
Sbjct: 2638 ILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGER---STPL 2694

Query: 246  TTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQ--SPVI 303
            T +L  T+ L N+  +  +       P+ +  PVTTS        A+ S T A+  S  I
Sbjct: 2695 TNILVSTTLLANSEASTLSTT-----PVDTSTPVTTS------AEASSSPTTAEGTSMRI 2743

Query: 304  TTTAAHATD-SALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHT 362
            +T +  +T  +++   TL +    ++ +S      S  VTT     S P          T
Sbjct: 2744 STPSDGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSSP----------T 2793

Query: 363  MAQKTIFSTGTPVAAATVAPILATNTIPSATT-AGSVSHTQAPTSTIVTMTVPSHSSHAT 421
             A+ T   T TP   +T    +  N  P A++ AG++S T   TST VT +  + SS  T
Sbjct: 2794 TAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKASSSPTT 2853

Query: 422  AVTTSNIPVAKVVPQQITHTSPRIQ--PDYPAERSSL--IPISGHRASPNPVAMETRSDN 477
            A     +P++         TS  +   P   +E S+L   P+     +  PV   T   +
Sbjct: 2854 AEGIV-VPISTASEGSTLLTSIPVSTTPVASSEASTLSTTPVD----TSIPVTTSTEGSS 2908

Query: 478  RPSVPVQFQYFLPTYPPSAYPLAAHTYTPIT---SSVSTIRQYPVSAQAPNSAITAQTGV 534
             P+        + T    + PL +   + +    S  ST+   PV  + P    T+    
Sbjct: 2909 SPTTAEGTSMPISTPSEVSTPLTSILVSTVPVAGSEASTLSTTPVDTRTP--VTTSAEAS 2966

Query: 535  GVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIG---------TPGIQPAP 585
               +T     M + T          G +  P+++  +   P+          TP     P
Sbjct: 2967 SSPTTAEGTSMPIST---------PGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTP 3017

Query: 586  LGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPA-A 644
            + T    S++P   +G    P+ T     EG T    +    T VA P ++  S  P  +
Sbjct: 3018 VTTSTEASSSPTTAEGTG-IPISTPS---EGSTPLTSIPVSTTPVAIPEASTLSTTPVDS 3073

Query: 645  TTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVS-METVSN 703
             + V T ++ +S+  PA+G+S   S       ++G+ P + + VS  TPVT S + T+S 
Sbjct: 3074 NSPVVTSTEVSSSPTPAEGTSMPISTY-----SEGSTPLTGVPVS-TTPVTSSAISTLST 3127

Query: 704  QNNDQPTIAVPPT-AQQPPPTIPTMIAAASPPSQPAVALSTIP--------------GAV 748
               D  T     T A   P T        S PS+ +  L+ +P               A 
Sbjct: 3128 TPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSAT 3187

Query: 749  PI--TPPITTIAAAPP---------PSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPV 797
            P+  + P+TT   A           P+ T    ++ +   PV    V      +    PV
Sbjct: 3188 PVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPV 3247

Query: 798  SAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTD 857
             +  PL T+T + S    A   SMPTS    G++P          +++ E   + T   D
Sbjct: 3248 DSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPAD 3307

Query: 858  DEKSTAKSLLVKAEKRKSPP 877
                T+  +   ++   SPP
Sbjct: 3308 ----TSTPVTTYSQASSSPP 3323



 Score =  113 bits (282), Expect = 1e-24
 Identities = 210/922 (22%), Positives = 343/922 (37%), Gaps = 85/922 (9%)

Query: 39   STGLSQAP---SQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSR--EEKQ 93
            ST L+  P   + +A+S    L    A  +      S+ S+    +  +S+Q+    E  
Sbjct: 1513 STALTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTSMQTSTYSEGS 1572

Query: 94   EPVVVRPYPQVQMLSTHHAVASATPV--------------AVTAPPAHLTPAVPLSFSEG 139
             P+   P   + ++S+     S TP+              + TA  + +T + P   S  
Sbjct: 1573 TPLTSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSEGSPL 1632

Query: 140  LMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQ--VTVTMESSIP---QASAIPVATISGQ 194
            L   P   T    P+A    STLS  P       +T T  SS P   + +++P +T + +
Sbjct: 1633 LTSIPVSTT----PVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYT-E 1687

Query: 195  QGHPSNLHHIMTTNVQMSIIRSNAPGP---PLHIGASHLPRGAAAAAVMSSSKVTTVLRP 251
               P     + TT V  S I + +  P      +  S   R +   +  +S   +T    
Sbjct: 1688 GRTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSEG 1747

Query: 252  TSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHAT 311
            T+ L +   +   V       + S  P+ TS  +  +  AT S T A+   I T      
Sbjct: 1748 TTPLTSIPVSTTPVLSSEASTL-SATPIDTSTPVTTSTEATSSPTTAEGTSIPT------ 1800

Query: 312  DSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFST 371
             S LS     +   P +   +     S   TT +   S     T      T A+ T  +T
Sbjct: 1801 -STLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIAT 1859

Query: 372  GTPVAAATVAPIL--ATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIP 429
             TP   +T    +  +T T+ S+ T  ++S T A TST VT T    SS  T    S++P
Sbjct: 1860 STPSEGSTALTSIPVSTTTVASSET-NTLSTTPAVTSTPVT-TYAQVSSSPTTADGSSMP 1917

Query: 430  VAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPN-PVAMETRSDNRPSVPVQFQYF 488
             +     +   TS  +     A  S +  +S   A    PV   +++ + P+        
Sbjct: 1918 TSTPREGRPPLTSIPVSTTTVAS-SEINTLSTTLADTRTPVTTYSQASSSPTTADGTSMP 1976

Query: 489  LPTYPPSAYPLAA---HTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPM 545
             P Y   + PL +    T   ++S  ST+   PV    P  A T+  G    +T     +
Sbjct: 1977 TPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTP--ATTSTEGSSSPTTAGGTSI 2034

Query: 546  QLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPA 605
            Q  T  +     + G+   P+ST  +  +   T    P    TQ  +S    ++   + +
Sbjct: 2035 QTST-PSERTTPLAGM---PVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSATAEGS 2090

Query: 606  PMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPA-ATTVVQTHSQSASTNAPAQGS 664
             M    P  EG      +    T VA+P ++  S  P  + + V T ++ +S+  P +G+
Sbjct: 2091 SMTISAPS-EGSPLLTSIPLSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEGT 2149

Query: 665  SPRPSIL--RKKP-----------ATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQ--- 708
            S + S    R+ P           A+      S   V  +TPVT S E  S+    +   
Sbjct: 2150 SMQTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTS 2209

Query: 709  -----PTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALST-IPGAVPITPPITTIAAAPP 762
                 P+    P    P  T+P + + AS  S   V  ST +  +   T   TT      
Sbjct: 2210 MPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAEGTSI 2269

Query: 763  PSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMP 822
            P+ T+    + +   PV    V           PV +  P  T+T + S    A   SMP
Sbjct: 2270 PTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSMP 2329

Query: 823  TSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEK-----STAKSLLVKAEKRKSPP 877
            TS    G +P  +      ++++ E   + T   D        S A S    A+    P 
Sbjct: 2330 TSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTSTPVTTYSQAGSSPTTADDTSMPT 2389

Query: 878  KEYID-EEGVRYVPVRPRPPIT 898
              Y +    +  VPV   P ++
Sbjct: 2390 STYSEGSTPLTSVPVSTMPVVS 2411



 Score =  113 bits (282), Expect = 1e-24
 Identities = 192/859 (22%), Positives = 331/859 (38%), Gaps = 115/859 (13%)

Query: 38   PSTGLSQAPSQIANSGSAGL----INPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQ 93
            P TG+  + + + +S  + L    ++ +  V   +   S  +  E  S  +S  S  E  
Sbjct: 3106 PLTGVPVSTTPVTSSAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPS--EGS 3163

Query: 94   EPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPT----- 148
             P+   P   + ++S+  +  SATPV  + P    T A   + +EG   P   P+     
Sbjct: 3164 TPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTP 3223

Query: 149  -----MPSRPIAPAPPSTLSLPP---KVPGQVTVTMESSIPQASAIPVATISGQQGH-PS 199
                 + + P+A +  S LS  P     P   +    SS P A    + T +  +G  P 
Sbjct: 3224 LTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPL 3283

Query: 200  NLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNA- 258
                + TT V  S   + +  P                   +S+ VTT  + +S  P A 
Sbjct: 3284 TSMPVSTTTVASSETSTLSTTP-----------------ADTSTPVTTYSQASSSPPIAD 3326

Query: 259  ATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTT-AAHATDSALSR 317
             T+ P   +      +   P+T  +     VV++ ++T + +PV T+T    +T+++LS 
Sbjct: 3327 GTSMPTSTY-----SEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEASLSP 3381

Query: 318  PTLSIQHPPSAAIS-----------IQRPAQSRDVTTRITLP----SHPALGTPKQQLHT 362
             T      P+++ S              P  S +V T  T P    +     T      T
Sbjct: 3382 TTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEASSSPT 3441

Query: 363  MAQKTIFSTGTPVAAATVAPILATNTIPSATT-AGSVSHTQAPTSTIVTMTVPSHSSHAT 421
            +A+ T   T T    +T   I+  +T P A++ A ++S T   TST VT + P++SS  T
Sbjct: 3442 IAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTNSSPTT 3501

Query: 422  A-VTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSL--IPI-------SGHRASPNPVAM 471
            A VT+     A      +T+      P   +E S+L   P+       S  +AS +P  +
Sbjct: 3502 AEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSPATL 3561

Query: 472  ETRSDNRPSVPVQFQYFLPT-YPPSAYPLAAHTYTPITSSVSTIRQYPVSAQA-----PN 525
            +  +  R S P +    L T    S Y  ++   TP T SV        S Q+     P 
Sbjct: 3562 QV-TTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPP 3620

Query: 526  SAIT--AQTGVGVASTVHLNPMQLMTVDASHARHIQ--------------GIQPAPISTQ 569
              IT    T   V++ + + P+   +V  S A                   +  +P++ +
Sbjct: 3621 EVITLPMSTPSEVSTPLTIMPVSTTSVTISEAGTASTLPVDTSTPVITSTQVSSSPVTPE 3680

Query: 570  GIQPAPIGTPGIQPAPLGTQGIHSATPINTQG--LQPAPMGTQQPQPEGKTSAVVLADGA 627
            G    PI TP     PL T  + +    +++G  L    + T  P     TS   ++  A
Sbjct: 3681 G-TTMPIWTPSEGSTPLTTMPVSTTRVTSSEGSTLSTPSVVTSTPV---TTSTEAISSSA 3736

Query: 628  TI--VANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSE 685
            T+      +S P   +   TT++   S +  T  P   +   PS+      T  ++  S 
Sbjct: 3737 TLDSTTMSVSMPMEISTLGTTILV--STTPVTRFPESSTPSIPSVYTSMSMTTASEGSSS 3794

Query: 686  IHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIP 745
               ++    T+ M T S ++    T+ + P +   P    T+       S P +  ST  
Sbjct: 3795 -PTTLEGTTTMPMSTTSERSTLLTTVLISPISVMSPSEASTLSTPPGDTSTPLLT-STKA 3852

Query: 746  GAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLAT 805
            G+  I   +TTI            S++S    P+  + V   +        +++ PPL T
Sbjct: 3853 GSFSIPAEVTTIRI----------SITSERSTPLTTLLVSTTLPTSFPGASIASTPPLDT 3902

Query: 806  NTVSPSLALLANNLSMPTS 824
            +T        A+  ++P +
Sbjct: 3903 STTFTPSTDTASTPTIPVA 3921



 Score =  112 bits (279), Expect = 2e-24
 Identities = 187/881 (21%), Positives = 314/881 (35%), Gaps = 65/881 (7%)

Query: 38   PSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSR--EEKQEP 95
            P T    + + +ANS ++ L       N      +E S+    +  +S+ +    E   P
Sbjct: 984  PLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTP 1043

Query: 96   VVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFS-EGLMKPPPKPTMPSRPI 154
            +   P     + S+  +  S TP   + P    + A   S + +G   P    +  S P+
Sbjct: 1044 LTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGTSMPTSTYSEGSTPL 1103

Query: 155  APAP----------PSTLSLPP---KVPGQVTVTMESSIPQASAIPVATISGQQGHPSNL 201
               P           STLS  P    +P   +    SS   A    + T    +G     
Sbjct: 1104 TSVPVSTRLVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLA 1163

Query: 202  HHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATA 261
               ++T + +S   +     P+    + +     A++   +++VT++  PTS  P   + 
Sbjct: 1164 SMPVSTTLVVSSEANTLSTTPVD-SKTQVATSTEASSPPPTAEVTSM--PTST-PGERST 1219

Query: 262  QPAVQHIIHQPIQSRPPVTTSNA-IPPAVVATVSATRAQSPVITTTAAHATDSALSRPTL 320
                  + H P+ S    T S + +  +   T SA  + SP      +  T +     TL
Sbjct: 1220 PLTSMPVRHTPVASSEASTLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTL 1279

Query: 321  SIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATV 380
                P S  + +  P  S  +TT +                T A+ T   T T     T 
Sbjct: 1280 LTSIPVSTTL-VTSPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTP 1338

Query: 381  APILATNTIPSATTAGSV-SHTQAPTSTIVTMTVPSHSSHATAVTTS---NIPVAKVVPQ 436
               +  NT   A++A S+ S T    ST VT +  + SS  T+  TS   + P     P 
Sbjct: 1339 LTSIPVNTTLVASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTP- 1397

Query: 437  QITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSA 496
             +T       P   +E S+L       ++P   + E  S    +  +      P+   + 
Sbjct: 1398 -LTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTP 1456

Query: 497  YPLAAHTYTPITSS-VSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHA 555
                  + TP+ +S  ST+   PV +   NS +   T V  + T        ++  +  +
Sbjct: 1457 LKSIPVSNTPVANSEASTLSTTPVDS---NSPVVTSTAVSSSPTPAEGTSIAISTPSEGS 1513

Query: 556  RHIQGIQPAPISTQGIQPAPIG----TPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQ 611
              +  I   P+ST  +  + I     TP +   P+ T    S++P    G     M T  
Sbjct: 1514 TALTSI---PVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTS---MQTST 1567

Query: 612  PQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPS-- 669
               EG T    L     +V +  +N  S  P  +    T S  AS++  A+GSS   S  
Sbjct: 1568 -YSEGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTP 1626

Query: 670  -----ILRKKP------ATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQ 718
                 +L   P      A+  A   S   V   +PV  S E  S+    + T     T  
Sbjct: 1627 SEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYT 1686

Query: 719  QPPPTIPTMIAAASPPSQPAVA-LSTIP--GAVPITPPI------TTIAAAPPPSVTVGG 769
            +    + ++    +P +  A++ LST P   + P+T         TT      P+ T   
Sbjct: 1687 EGRTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSE 1746

Query: 770  SLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPG 829
              + +   PV    V           P+    P+ T+T + S    A   S+PTS L  G
Sbjct: 1747 GTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEG 1806

Query: 830  ASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKA 870
             +P         +++  E   + T   D       S  V +
Sbjct: 1807 MTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVSS 1847



 Score =  107 bits (266), Expect = 8e-23
 Identities = 224/943 (23%), Positives = 350/943 (37%), Gaps = 141/943 (14%)

Query: 28   SSQQFPRLGAPSTGLSQAP-------SQIANSGSAGLINPAATVNDESGRDSEVSAREHM 80
            +S Q       ST L+  P       S  AN+ S   I+    V   +   S  +A    
Sbjct: 1561 TSMQTSTYSEGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAE--- 1617

Query: 81   SSSSSLQSREEKQE-----PVVVRPY--PQVQMLST-----HHAVASATPVAVTAPPAHL 128
             SS ++ +  E        PV   P   P+   LST     +  V ++T V+ +  PA  
Sbjct: 1618 GSSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEG 1677

Query: 129  TPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPP---KVPGQVTVTMESSIPQASA 185
            T     +++EG   P    T+ + P+A +  STLS  P     P   +    SS   +  
Sbjct: 1678 TSMPTSTYTEG-RTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEG 1736

Query: 186  IPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIG--------ASHLPRGAAAA 237
              +   +  +G        ++T   +S   S     P+           A+  P  A   
Sbjct: 1737 TSMPNSTPSEGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGT 1796

Query: 238  AVMSSSKVTTVLRPTSQLPNAAT--AQPAVQHIIHQPIQSRPPVTTSNAI---PPAVVAT 292
            ++ +S+ ++  + P +  P + T  A      +   P+ S  PV TS A+   P     T
Sbjct: 1797 SIPTST-LSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGT 1855

Query: 293  VSATRAQS---------PVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTT 343
              AT   S         PV TTT A +  + LS        P +    +     + D ++
Sbjct: 1856 SIATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPTTADGSS 1915

Query: 344  RITLPSHPALGTP-------------KQQLHTMAQKTIFSTGTPVAA---ATVAPILATN 387
              T  S P  G P               +++T++  T+  T TPV     A+ +P  A  
Sbjct: 1916 MPT--STPREGRPPLTSIPVSTTTVASSEINTLST-TLADTRTPVTTYSQASSSPTTADG 1972

Query: 388  T-IPS-ATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTS--P 443
            T +P+ A + GS   T  P ST + ++  + +   T V TS              T+   
Sbjct: 1973 TSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSSPTTAGGT 2032

Query: 444  RIQPDYPAERSSLI---PIS--------GHRASPNPVAMETRSDNRP----SVPVQFQYF 488
             IQ   P+ER++ +   P+S        G+  S  PV  +T+  N      S   +    
Sbjct: 2033 SIQTSTPSERTTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSATAEGSSM 2092

Query: 489  LPTYPPSAYPLAAH---TYTPITS-SVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNP 544
              + P    PL      + TP+ S   ST+   PV +   NS +   T V  +S +    
Sbjct: 2093 TISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVDS---NSPVITSTEVS-SSPIPTEG 2148

Query: 545  MQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHS----ATPINTQ 600
              + T   S  R    +   P+ST  +  + I T    P    T   +S    ++P  ++
Sbjct: 2149 TSMQTSTYSDRR--TPLTSMPVSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSE 2206

Query: 601  GLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAAT-TVVQTHSQSASTNA 659
            G     M T  P  EG T    +      V    ++  SA P  T T V T +++ S+  
Sbjct: 2207 GTS---MPTSTPS-EGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSPT 2262

Query: 660  PAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPT-AQ 718
             A+G+S   S L     ++G  P + I VS        + T+S    D  T     T A 
Sbjct: 2263 TAEGTSIPTSTL-----SEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTPFTTSTEAS 2317

Query: 719  QPPPT-----IPTMIAAAS-------PPSQPAVA------LSTIPG--AVPITP------ 752
             PPPT     +PT  ++         P S   VA      LST P   + P+T       
Sbjct: 2318 SPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTSTPVTTYSQAGS 2377

Query: 753  -PITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPS 811
             P T    + P S    GS + +   PV  + V           PV    P+ T+T + S
Sbjct: 2378 SPTTADDTSMPTSTYSEGS-TPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASS 2436

Query: 812  LALLANNLSMPTSDLPPGASP-RKKPRKQQHVISTEEGDMMET 853
                A   S+PTS    G +P    P     V+S+E G +  T
Sbjct: 2437 SPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLSTT 2479



 Score =  102 bits (255), Expect = 1e-21
 Identities = 174/804 (21%), Positives = 286/804 (35%), Gaps = 96/804 (11%)

Query: 103 QVQMLSTHHAVASATPVAVTAPPAHLT-PAVPLSFSEGLMKPPPKPTMPSRPIAPAPPST 161
           Q Q LS H    SA   A      ++  P + LS S       P+ T     +    P  
Sbjct: 51  QCQQLSQHVRTGSAANTATGTTSTNVVEPRMYLSCSTN-----PEMTSIESSVTSDTPG- 104

Query: 162 LSLPPKVPGQVTVTMESSIPQASAIPVATI-SGQQGHPSNLHHIMTTNVQMSIIRSNAPG 220
           +S     P +   T ES+    +  P +T  +     P      M+T  + SI  + A  
Sbjct: 105 VSSTRMTPTESRTTSESTSDSTTLFPSSTEDTSSPTTPEGTDVPMSTPSEESISSTMA-- 162

Query: 221 PPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQL------PNAATAQPAVQHIIHQPIQ 274
               +  + LP   A  ++     ++T L  ++Q       P + T   +       P+ 
Sbjct: 163 ---FVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQASSSPTTPESTTIPKSTNSEGSTPLT 219

Query: 275 SRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQR 334
           S P  T   A   A+    +     +PV  +  A ++ +    P+LS   P   +  +  
Sbjct: 220 SMPASTMKVASSEAITLLTTPVEISTPVTISAQASSSPTTAEGPSLSNSAPSGGSTPL-- 277

Query: 335 PAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVA---PILATNT-IP 390
                   TR+ L     + +    L T    T  +T  PV  +T A   P  A  T IP
Sbjct: 278 --------TRMPLSVMLVVSSEASTLST----TPAATNIPVITSTEASSSPTTAEGTSIP 325

Query: 391 SAT-TAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDY 449
           ++T T GS   T  P ST+   T    +   T V TS +      P  +  T+       
Sbjct: 326 TSTYTEGSTPLTSTPASTMPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLT 385

Query: 450 PAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITS 509
                   P++    S   VA  + +    ++PV  + F+             T +  +S
Sbjct: 386 STLSEGSTPLTNMPVSTILVA-SSEASTTSTIPVDSKTFVT------------TASEASS 432

Query: 510 SVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQ 569
           S +T     ++   P+   T  T + V++T    P+            +        ST+
Sbjct: 433 SPTTAEDTSIATSTPSEGSTPLTSMPVSTT----PVASSEASNLSTTPVDSKTQVTTSTE 488

Query: 570 GIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATI 629
                P       P    ++G   +TP+ +  +   P+ +     E  T +    D +T 
Sbjct: 489 ASSSPPTAEVNSMPTSTPSEG---STPLTSMSVSTMPVASS----EASTLSTTPVDTST- 540

Query: 630 VANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVS 689
              P++    A+ ++TT   T   S  T+ P++GS+P    L   P +      SE   +
Sbjct: 541 ---PVTTSSEASSSSTTPEGT---SIPTSTPSEGSTP----LTNMPVSTRLVVSSEASTT 590

Query: 690 MATP------VTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTM-IAAASPPSQPAVALS 742
             TP      VT S E  S+    + T     T  +   TI +M ++     S  A  LS
Sbjct: 591 STTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLS 650

Query: 743 TIPGAVPITPPITTIAAAPPPSVTVGGS----------LSSVLGPPVPEIKVKEEVEPMD 792
           T P  V    P+TT   A   S T  G+           + +   PV    V        
Sbjct: 651 TTP--VDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTL 708

Query: 793 IMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMME 852
              PV    P+ T+T + S    A+  SMPTS    G++P       + ++++ E   + 
Sbjct: 709 STTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLS 768

Query: 853 TNSTDDEKSTAKSLLVKAEKRKSP 876
           T   D    T+  +    E   SP
Sbjct: 769 TTPLD----TSTHITTSTEASCSP 788



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 183/848 (21%), Positives = 310/848 (36%), Gaps = 77/848 (9%)

Query: 50   ANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLST 109
            A++ SA  ++ +  V   +   S  +  E  S  +S  S  E   P+   P     + ++
Sbjct: 2237 ASTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLS--EGTTPLTSIPVSHTLVANS 2294

Query: 110  HHAVASATPVAVTAPPAHLTPAV-PLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKV 168
              +  S TPV    P    T A  P   +EG   P    +  + P+   P ST      V
Sbjct: 2295 EVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTM----V 2350

Query: 169  PGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGAS 228
                T T+ S+ P  ++ PV T S     P+       T++  S   S    P   +  S
Sbjct: 2351 ASFETSTL-STTPADTSTPVTTYSQAGSSPTTADD---TSMPTSTY-SEGSTPLTSVPVS 2405

Query: 229  HLPRGAAAAAVMSSSKV--TTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIP 286
             +P  ++ A+  S++ V  +T +  +++  ++ T           P +   P+ +     
Sbjct: 2406 TMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVST 2465

Query: 287  PAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRIT 346
              VV++ + T + +PV T+T    +  A S PT +        + I   ++   + T I 
Sbjct: 2466 TPVVSSEAGTLSTTPVDTSTPMTTSTEASSSPTTA----EDIVVPISTASEGSTLLTSIP 2521

Query: 347  LPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTS 406
            + + P        L T    T   + +PV  +T     AT+   ++    + S    P  
Sbjct: 2522 VSTTPVASPEASTLST----TPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLR 2577

Query: 407  TIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASP 466
            ++   T P  SS A+ ++T+  PV   +P     TS          + + +PIS    +P
Sbjct: 2578 SMPVSTKPLASSEASTLSTT--PVDTSIP---VTTSTETSSSPTTAKDTSMPIS----TP 2628

Query: 467  NPVAMETRSDNRPSVPVQFQ--YFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAP 524
            + V+    S    ++PV       L T P     L   T T  +SS +T     +    P
Sbjct: 2629 SEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVT-TSTGTSSSPTTAEGSSMPTSTP 2687

Query: 525  NSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPG-IQP 583
                T  T + V++T+  N                 +   P+ T      P+ T      
Sbjct: 2688 GERSTPLTNILVSTTLLAN------------SEASTLSTTPVDTS----TPVTTSAEASS 2731

Query: 584  APLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPA 643
            +P   +G        + G  P         P   + A  ++  A   + P++    A+ +
Sbjct: 2732 SPTTAEGTSMRISTPSDGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSS 2791

Query: 644  ATTVVQTHSQSASTNAPAQGSSPRPS--ILRKKPATDGAKPKSEIHVSMATPVTVSMETV 701
             TT   T   S  T+ P++ S+P  S  +     A+  A   S   V  +TPVT S +  
Sbjct: 2792 PTTAEVT---SMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKAS 2848

Query: 702  SNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPP--SQPAVALSTIPGAVPITPPITTIAA 759
            S+    +  I VP +      T+ T I  ++ P  S  A  LST P  V  + P+TT   
Sbjct: 2849 SSPTTAE-GIVVPISTASEGSTLLTSIPVSTTPVASSEASTLSTTP--VDTSIPVTTSTE 2905

Query: 760  APPPSVTVGG-----SLSSVLGPPVPEIKVK------EEVEPMDIMRPVSAVPPLATNTV 808
                  T  G     S  S +  P+  I V        E   +    PV    P+ T+  
Sbjct: 2906 GSSSPTTAEGTSMPISTPSEVSTPLTSILVSTVPVAGSEASTLS-TTPVDTRTPVTTSAE 2964

Query: 809  SPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLV 868
            + S    A   SMP S      +P          +++ E   +     D    T+  +  
Sbjct: 2965 ASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSRTPAD----TSTPVTT 3020

Query: 869  KAEKRKSP 876
              E   SP
Sbjct: 3021 STEASSSP 3028



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 150/739 (20%), Positives = 262/739 (35%), Gaps = 92/739 (12%)

Query: 72   SEVSAREHMSSSSSL--QSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAP----- 124
            +E S+   ++  +SL   +  E   P+ + P     + S+  +  S TPV  + P     
Sbjct: 3434 TEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSS 3493

Query: 125  PAHLTP------AVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMES 178
            P + +P      ++P S +     P     + + P+A +  STLS  P V     VT  S
Sbjct: 3494 PTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTP-VDSNTFVTSSS 3552

Query: 179  ---SIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAA 235
               S P    +    +S      S+L  ++ ++  ++   ++ P  P             
Sbjct: 3553 QASSSPATLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTP------------- 3599

Query: 236  AAAVMSSSKVTTVLRPTSQL--PNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATV 293
              +V  S+ VTT  +  S    P   T   +    +  P+   P  TTS  I  A  A+ 
Sbjct: 3600 --SVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIMPVSTTSVTISEAGTAST 3657

Query: 294  SATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPAL 353
                  +PVIT+T   ++       T+ I  P   +  +     S   TTR+T      L
Sbjct: 3658 LPVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPLTTMPVS---TTRVTSSEGSTL 3714

Query: 354  GTPKQQLHTMA-------------QKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSH 400
             TP     T                 T  S   P+  +T+   +  +T P      S + 
Sbjct: 3715 STPSVVTSTPVTTSTEAISSSATLDSTTMSVSMPMEISTLGTTILVSTTPVTRFPESSTP 3774

Query: 401  TQAPTSTIVTMTVPSH--SSHATAVTTSNIPVAKVVPQQITHTSPRIQPDY---PAERSS 455
            +     T ++MT  S   SS  T   T+ +P++    +    T+  I P     P+E S+
Sbjct: 3775 SIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTLLTTVLISPISVMSPSEAST 3834

Query: 456  LIPISGHRASPNPVAMETRSDNRPSVPVQFQY-------------FLPTYPPSAYPLAAH 502
            L    G  ++P   + +  S + P+     +               + T  P+++P A+ 
Sbjct: 3835 LSTPPGDTSTPLLTSTKAGSFSIPAEVTTIRISITSERSTPLTTLLVSTTLPTSFPGASI 3894

Query: 503  TYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQ 562
              TP   + +T      +A  P   +     V V  T    P   + + ++         
Sbjct: 3895 ASTPPLDTSTTFTPSTDTASTPTIPVATTISVSVI-TEGSTPGTTIFIPST--------- 3944

Query: 563  PAPISTQGIQPAPIG---TPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTS 619
            P   ST  + PA  G   TP I    L T    S++   +         T++      T+
Sbjct: 3945 PVTSSTADVFPATTGAVSTPVITSTELNTPSTSSSSTTTSFST------TKEFTTPAMTT 3998

Query: 620  AVVLA--DGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPAT 677
            A  L     +T  + P +       +A+T+  T +   ST+   +  +P     R    T
Sbjct: 3999 AAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATSTPHTSTSVTTRPVTPSSESSRPSTIT 4058

Query: 678  DGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQP 737
                P +      +TP T S  + +       T+           + PT+   A P +  
Sbjct: 4059 SHTIPPTFPPAHSSTPPTTSASSTTVNPEAVTTMTTRTKPSTRTTSFPTVTTTAVPTN-- 4116

Query: 738  AVALSTIPGAVPITPPITT 756
               + + P + P  P  TT
Sbjct: 4117 -TTIKSNPTSTPTVPRTTT 4134



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 105/474 (22%), Positives = 180/474 (37%), Gaps = 67/474 (14%)

Query: 38   PSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVV 97
            P T +  + +++ +S  + L  P+   +         ++ E +SSS++L S       + 
Sbjct: 3695 PLTTMPVSTTRVTSSEGSTLSTPSVVTSTPV-----TTSTEAISSSATLDSTT-----MS 3744

Query: 98   VRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSF--------SEGLMKPPPKPTM 149
            V    ++  L T   V S TPV  T  P   TP++P  +        SEG   P      
Sbjct: 3745 VSMPMEISTLGTTILV-STTPV--TRFPESSTPSIPSVYTSMSMTTASEGSSSPTTLEGT 3801

Query: 150  PSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIP--------VATISGQQGHPSNL 201
             + P++     +  L   +   ++V   S     S  P         +T +G    P+ +
Sbjct: 3802 TTMPMSTTSERSTLLTTVLISPISVMSPSEASTLSTPPGDTSTPLLTSTKAGSFSIPAEV 3861

Query: 202  HHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATA 261
                 T +++SI    +      + ++ LP     A++ S+  + T    T     A+T 
Sbjct: 3862 -----TTIRISITSERSTPLTTLLVSTTLPTSFPGASIASTPPLDTSTTFTPSTDTASTP 3916

Query: 262  QPAVQHIIHQPIQSR------------PPVTTSNA-IPPAVVATVSATRAQSPVITTTAA 308
               V   I   + +              PVT+S A + PA    VS     +PVIT+T  
Sbjct: 3917 TIPVATTISVSVITEGSTPGTTIFIPSTPVTSSTADVFPATTGAVS-----TPVITSTEL 3971

Query: 309  HATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTI 368
            +   ++ S  T S              A      T  T PS P   T  +   T A  T+
Sbjct: 3972 NTPSTSSSSTTTSFSTTKEFTTPAMTTAAPLTYVTMSTAPSTPR--TTSRGCTTSAS-TL 4028

Query: 369  FSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNI 428
             +T TP  + +V     T +  S+  +   SHT  PT        P+HSS     + S+ 
Sbjct: 4029 SATSTPHTSTSVTTRPVTPSSESSRPSTITSHTIPPTFP------PAHSSTPPTTSASS- 4081

Query: 429  PVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVP 482
                V P+ +T  + R +   P+ R++  P     A P    +++   + P+VP
Sbjct: 4082 --TTVNPEAVTTMTTRTK---PSTRTTSFPTVTTTAVPTNTTIKSNPTSTPTVP 4130


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score =  120 bits (302), Expect = 5e-27
 Identities = 178/792 (22%), Positives = 261/792 (32%), Gaps = 81/792 (10%)

Query: 95   PVVVRPYPQVQMLSTHHAVASATP--VAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSR 152
            P    P P     +T     + +P     T PP   TP+ P++ +      PP  T PS 
Sbjct: 1401 PPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTT----TPPPTTTPSP 1456

Query: 153  PIA----PAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTN 208
            PI+    P P +T S P   P   T T        +  P  T       P     I    
Sbjct: 1457 PISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPS----PPTTTPITPPA 1512

Query: 209  VQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRP---TSQLPNAATAQPAV 265
               ++  +  P PP     +  P          S   TT + P   T+ LP   T  P  
Sbjct: 1513 STTTLPPTTTPSPPTTTTTTPPP------TTTPSPPTTTPITPPTSTTTLPPTTTPSPPP 1566

Query: 266  QHIIHQPIQSRP-PVTTSNAIPPAVVATV-SATRAQSPVITTTAAHATDSALSRPTLSIQ 323
                  P  + P P TT+   PP +  T    T   SP  TTT      +  S PT +  
Sbjct: 1567 TTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPI 1626

Query: 324  HPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPI 383
             PP++  ++          T  T P  P   TP     T     I +T TP    T +  
Sbjct: 1627 TPPTSTTTLPPTTTPSPPPTTTTTP--PPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSP 1684

Query: 384  LATNTIPSATTAGSVSHTQAPTSTIVTMTVPSH-SSHATAVTTSNIPVAKVVPQQITHTS 442
            + T   P  TT  + S T  P+S I T T PS  ++ +   TT   P     P   T T 
Sbjct: 1685 ITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTM 1744

Query: 443  PRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPV-QFQYFLPTYPPSAYPLAA 501
              + P   +   +  P+      P      T +   P VP+  +  +L +  P+ +    
Sbjct: 1745 TTLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTPTTPCVPLCNWTGWLDSGKPNFHKPGG 1804

Query: 502  HT-----------YTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQL--M 548
             T              I+   +     P+             G+ +       P  +  M
Sbjct: 1805 DTELIGDVCGPGWAANISCRATMYPDVPIGQLGQTVVCDVSVGL-ICKNEDQKPGGVIPM 1863

Query: 549  TVDASHARHIQ----GIQPAPISTQGIQ-PAPIGTPGI--------QPAPLGTQGIHSAT 595
                ++  ++Q      QP  ++T   + P P  T  I         P P GTQ   + T
Sbjct: 1864 AFCLNYEINVQCCECVTQPTTMTTTTTENPTPPTTTPITTTTTVTPTPTPTGTQ-TPTTT 1922

Query: 596  PINTQGL---QPAPMGTQQP--QPEGKTSAVVLADGATIVANPISNPFSAAPAAT-TVVQ 649
            PI T       P P GTQ P   P   T+ V      T    P + P +     T T   
Sbjct: 1923 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 1982

Query: 650  THSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQP 709
            T +Q+ +T      ++  P+       T    P +       TP     +T +       
Sbjct: 1983 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2042

Query: 710  TIAVP---PTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPP---- 762
            T   P   PT  Q P T P        P+       T     P T PITT     P    
Sbjct: 2043 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----PTTTPITTTTTVTPTPTP 2097

Query: 763  -----PSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLAN 817
                 P+ T   + ++V   P P         P+     V+   P  T T +P+   +  
Sbjct: 2098 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITT 2156

Query: 818  NLSMPTSDLPPG 829
              ++  +  P G
Sbjct: 2157 TTTVTPTPTPTG 2168



 Score =  112 bits (280), Expect = 2e-24
 Identities = 167/757 (22%), Positives = 239/757 (31%), Gaps = 57/757 (7%)

Query: 115  SATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAP-PSTLSLPPKVPGQVT 173
            + T    T P    T   P     G   P   P   +  + P P P+    P   P   T
Sbjct: 3547 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3606

Query: 174  VTME-------SSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIG 226
             T+        +  P  + I   T       P+      TT +  +   +  P P     
Sbjct: 3607 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3666

Query: 227  ASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIP 286
             +  P         + +   T    T+ +    T  P       Q   +  P+TT+  + 
Sbjct: 3667 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-PTTTPITTTTTVT 3725

Query: 287  PAVVATVSATRAQSPVITTTAAHATDSALSRPT--------LSIQHPPSAAISIQRPAQS 338
            P    T + T   +P+ TTT    T +     T         +   P       Q P  +
Sbjct: 3726 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3785

Query: 339  RDVTTRITLPSHPALGTPKQQ---LHTMAQKTIFSTGTPVAAATVAPILATNTI-PSATT 394
               TT    P+    GT       + T    T   T T     T  PI  T T+ P+ T 
Sbjct: 3786 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3845

Query: 395  AGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERS 454
             G+ + T  P +T  T+T     +     TT+ I     V    T T  +     P   +
Sbjct: 3846 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3905

Query: 455  SLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHT--YTPITSSVS 512
            + +       +P P    T++     +         T  P+  P    T   TPIT++ +
Sbjct: 3906 TTV-------TPTPTPTGTQTPTTTPITTT-----TTVTPTPTPTGTQTPTTTPITTTTT 3953

Query: 513  -TIRQYPVSAQAPNSA-ITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQG 570
             T    P   Q P +  IT  T V    T      Q  T             P P  TQ 
Sbjct: 3954 VTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPITTTTTVTPTPTPTGTQT 4011

Query: 571  IQPAPIGTPGI---QPAPLGTQGIHSATPINTQGL---QPAPMGTQQPQ--PEGKTSAVV 622
                PI T       P P GTQ   + TPI T       P P GTQ P   P   T+ V 
Sbjct: 4012 PTTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 4070

Query: 623  LADGATIVANPISNPFSAAPAAT-TVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAK 681
                 T    P + P +     T T   T +Q+ +T      ++  P+       T    
Sbjct: 4071 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 4130

Query: 682  PKSEIHVSMATPVTVSMETVSNQNNDQPTIAVP---PTAQQPPPTIPTMIAAASPPSQPA 738
            P +       TP     +T +       T   P   PT  Q P T P        P+   
Sbjct: 4131 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 4190

Query: 739  VALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVS 798
                T P     T PI  +  + PP  +     S     P+ E        P  I    +
Sbjct: 4191 TGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTST 4250

Query: 799  AVPPLATNTVSPSLALLANNLSMP--TSDLPPGASPR 833
            A P   T   +P+     + LS P  T+  PPG   R
Sbjct: 4251 APPSTPT---APTTTSGGHTLSPPPSTTTSPPGTPTR 4284



 Score =  111 bits (278), Expect = 3e-24
 Identities = 158/700 (22%), Positives = 232/700 (33%), Gaps = 59/700 (8%)

Query: 115  SATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAP-PSTLSLPPKVPGQVT 173
            + T    T P    T   P     G   P   P   +  + P P P+    P   P   T
Sbjct: 3639 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3698

Query: 174  VTME-------SSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIG 226
             T+        +  P  + I   T       P+      TT +  +   +  P P     
Sbjct: 3699 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3758

Query: 227  ASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIP 286
             +  P         + +   T    T+ +    T  P       Q   +  P+TT+  + 
Sbjct: 3759 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-PTTTPITTTTTVT 3817

Query: 287  PAVVATVSATRAQSPVITTTAAHATDSALSRPT--------LSIQHPPSAAISIQRPAQS 338
            P    T + T   +P+ TTT    T +     T         +   P       Q P  +
Sbjct: 3818 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3877

Query: 339  RDVTTRITLPSHPALGTPKQQ---LHTMAQKTIFSTGTPVAAATVAPILATNTI-PSATT 394
               TT    P+    GT       + T    T   T T     T  PI  T T+ P+ T 
Sbjct: 3878 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3937

Query: 395  AGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERS 454
             G+ + T  P +T  T+T     +     TT+ I     V    T T  +     P   +
Sbjct: 3938 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3997

Query: 455  SLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHT--YTPITSSVS 512
            + +       +P P    T++     +         T  P+  P    T   TPIT++ +
Sbjct: 3998 TTV-------TPTPTPTGTQTPTTTPITTT-----TTVTPTPTPTGTQTPTTTPITTTTT 4045

Query: 513  -TIRQYPVSAQAPNSA-ITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQG 570
             T    P   Q P +  IT  T V    T      Q  T             P P  TQ 
Sbjct: 4046 VTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPITTTTTVTPTPTPTGTQT 4103

Query: 571  IQPAPIGTPGI---QPAPLGTQGIHSATPINTQGL---QPAPMGTQQPQ--PEGKTSAVV 622
                PI T       P P GTQ   + TPI T       P P GTQ P   P   T+ V 
Sbjct: 4104 PTTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 4162

Query: 623  LADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRP--SILRKKPATDGA 680
                 T    P + P +     TTV  T + + +   P   +S  P   +    P  + +
Sbjct: 4163 PTPTPTGTQTPTTTPITTT---TTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESS 4219

Query: 681  KPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVA 740
             P++    S ++P+T S   +S      P I +  TA    PT PT  +     S P   
Sbjct: 4220 TPQTSR--STSSPLTESTTLLSTL---PPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPST 4274

Query: 741  LSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVP 780
             ++ PG  P     T  ++AP PS     + S+    P P
Sbjct: 4275 TTSPPGT-PTRGTTTGSSSAPTPSTVQTTTTSAWTPTPTP 4313



 Score =  110 bits (276), Expect = 5e-24
 Identities = 175/784 (22%), Positives = 248/784 (31%), Gaps = 66/784 (8%)

Query: 115  SATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAP-PSTLSLPPKVPGQVT 173
            + T    T P    T   P     G   P   P   +  + P P P+    P   P   T
Sbjct: 3478 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3537

Query: 174  VTME-------SSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIG 226
             T+        +  P  + I   T       P+      TT +  +   +  P P     
Sbjct: 3538 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3597

Query: 227  ASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIP 286
             +  P         + +   T    T+ +    T  P       Q   +  P+TT+  + 
Sbjct: 3598 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-PTTTPITTTTTVT 3656

Query: 287  PAVVATVSATRAQSPVITTTAAHATDSALSRPT--------LSIQHPPSAAISIQRPAQS 338
            P    T + T   +P+ TTT    T +     T         +   P       Q P  +
Sbjct: 3657 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3716

Query: 339  RDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSV 398
               TT    P+    GT   Q  T    T  +T TP    T      T  I + TT   V
Sbjct: 3717 PITTTTTVTPTPTPTGT---QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT---V 3770

Query: 399  SHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIP 458
            + T  PT T    T P  ++  T VT +  P     P     T+       P    +  P
Sbjct: 3771 TPTPTPTGTQTPTTTPITTT--TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 3828

Query: 459  IS---GHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAH--TYTPITSSVS- 512
             +       +  P    T +    + P+       T  P+  P      T TPIT++ + 
Sbjct: 3829 TTTPITTTTTVTPTPTPTGTQTPTTTPIT---TTTTVTPTPTPTGTQTPTTTPITTTTTV 3885

Query: 513  TIRQYPVSAQAPNSA-ITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGI 571
            T    P   Q P +  IT  T V    T      Q  T             P P  TQ  
Sbjct: 3886 TPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPITTTTTVTPTPTPTGTQTP 3943

Query: 572  QPAPIGTPGI---QPAPLGTQGIHSATPINTQGL---QPAPMGTQQP--QPEGKTSAVVL 623
               PI T       P P GTQ   + TPI T       P P GTQ P   P   T+ V  
Sbjct: 3944 TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 4002

Query: 624  ADGATIVANPISNPFSAAPAAT-TVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKP 682
                T    P + P +     T T   T +Q+ +T      ++  P+       T    P
Sbjct: 4003 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 4062

Query: 683  KSEIHVSMATPVTVSMETVSNQNNDQPTIAVP---PTAQQPPPTIPTMIAAASPPSQPAV 739
             +       TP     +T +       T   P   PT  Q P T P        P+    
Sbjct: 4063 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 4122

Query: 740  ALSTIPGAVPITPPITTIAAAPP---------PSVTVGGSLSSVLGPPVPEIKVKEEVEP 790
               T     P T PITT     P         P+ T   + ++V   P P         P
Sbjct: 4123 GTQT-----PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 4177

Query: 791  MDIMRPVSAVP-PLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGD 849
            +     V+  P P  T T  P+    A    + TS+ PP +S  +  R     + TE   
Sbjct: 4178 ITTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPL-TESTT 4236

Query: 850  MMET 853
            ++ T
Sbjct: 4237 LLST 4240



 Score =  110 bits (275), Expect = 7e-24
 Identities = 146/677 (21%), Positives = 220/677 (32%), Gaps = 57/677 (8%)

Query: 115  SATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAP-PSTLSLPPKVPGQVT 173
            + T    T P    T   P     G   P   P   +  + P P P+    P   P   T
Sbjct: 3662 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3721

Query: 174  VTME-------SSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIG 226
             T+        +  P  + I   T       P+      TT +  +   +  P P     
Sbjct: 3722 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3781

Query: 227  ASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIP 286
             +  P         + +   T    T+ +    T  P       Q   +  P+TT+  + 
Sbjct: 3782 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-PTTTPITTTTTVT 3840

Query: 287  PAVVATVSATRAQSPVITTTAAHATDSALSRPT--------LSIQHPPSAAISIQRPAQS 338
            P    T + T   +P+ TTT    T +     T         +   P       Q P  +
Sbjct: 3841 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3900

Query: 339  RDVTTRITLPSHPALGTPKQQ---LHTMAQKTIFSTGTPVAAATVAPILATNTI-PSATT 394
               TT    P+    GT       + T    T   T T     T  PI  T T+ P+ T 
Sbjct: 3901 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3960

Query: 395  AGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERS 454
             G+ + T  P +T  T+T     +     TT+ I     V    T T  +     P   +
Sbjct: 3961 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 4020

Query: 455  SLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHT--YTPITSSVS 512
            + +       +P P    T++     +         T  P+  P    T   TPIT++ +
Sbjct: 4021 TTV-------TPTPTPTGTQTPTTTPITTT-----TTVTPTPTPTGTQTPTTTPITTTTT 4068

Query: 513  -TIRQYPVSAQAPNSA-ITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQG 570
             T    P   Q P +  IT  T V    T      Q  T             P P  TQ 
Sbjct: 4069 VTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPITTTTTVTPTPTPTGTQT 4126

Query: 571  IQPAPIGTPGI---QPAPLGTQGIHSATPINTQGL---QPAPMGTQQPQPEGKTSAVVLA 624
                PI T       P P GTQ   + TPI T       P P GTQ P      +   + 
Sbjct: 4127 PTTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTP------TTTPIT 4179

Query: 625  DGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKS 684
               T+   P        P   T     ++  ++N P + S+P+ S     P T+     S
Sbjct: 4180 TTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLS 4239

Query: 685  EI--HVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIP---TMIAAASPPSQPAV 739
             +   + M +    S  T     +   T++ PP+    PP  P   T   ++S P+   V
Sbjct: 4240 TLPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTV 4299

Query: 740  ALSTIPGAVPITPPITT 756
              +T     P   P++T
Sbjct: 4300 QTTTTSAWTPTPTPLST 4316



 Score =  108 bits (271), Expect = 2e-23
 Identities = 164/760 (21%), Positives = 239/760 (31%), Gaps = 67/760 (8%)

Query: 115  SATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAP-PSTLSLPPKVPGQVT 173
            + T    T P    T   P     G   P   P   +  + P P P+    P   P   T
Sbjct: 1914 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 1973

Query: 174  VTME-------SSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIG 226
             T+        +  P  + I   T       P+      TT +  +   +  P P     
Sbjct: 1974 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2033

Query: 227  ASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIP 286
             +  P         + +   T    T+ +    T  P       Q   +  P+TT+  + 
Sbjct: 2034 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVT 2092

Query: 287  PAVVATVSATRAQSPVITTTAAHATDSALSR--------PTLSIQHPPSAAISIQRPAQS 338
            P    T + T   +P+ TTT    T +             T +   P       Q P  +
Sbjct: 2093 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2152

Query: 339  RDVTTRITLPSHPALGT---PKQQLHTMAQKTIFSTGTPVAAATVAPILATNTI-PSATT 394
               TT    P+    GT       + T    T   T T     T  PI  T T+ P+ T 
Sbjct: 2153 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2212

Query: 395  AGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERS 454
             G+ + T  P +T  T+T     +     TT+ I     V    T T  +     P   +
Sbjct: 2213 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2272

Query: 455  SLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAH--TYTPITSSVS 512
            + +       +P P    T++     +         T  P+  P      T TPIT++ +
Sbjct: 2273 TTV-------TPTPTPTGTQTPTTTPITT-----TTTVTPTPTPTGTQTPTTTPITTTTT 2320

Query: 513  -TIRQYPVSAQAPNSA-ITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQG 570
             T    P   Q P +  IT  T V    T      Q  T             P P  TQ 
Sbjct: 2321 VTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPITTTTTVTPTPTPTGTQT 2378

Query: 571  IQPAPIGTPGI---QPAPLGTQGIHSATPINTQGL---QPAPMGTQQP--QPEGKTSAVV 622
                PI T       P P GTQ   + TPI T       P P GTQ P   P   T+ V 
Sbjct: 2379 PTTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2437

Query: 623  LADGATIVANPISNPFSAAPAAT-TVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAK 681
                 T    P + P +     T T   T +Q+ +T      ++  P+       T    
Sbjct: 2438 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2497

Query: 682  PKSEIHVSMATPVTVSMETVSNQNNDQPTIAVP---PTAQQPPPTIPTMIAAASPPSQPA 738
            P +       TP     +T +       T   P   PT  Q P T P        P+   
Sbjct: 2498 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2557

Query: 739  VALSTIPGAVPITPPITTIAAAPP---------PSVTVGGSLSSVLGPPVPEIKVKEEVE 789
                T     P T PITT     P         P+ T   + ++V   P P         
Sbjct: 2558 TGTQT-----PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2612

Query: 790  PMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPG 829
            P+     V+   P  T T +P+   +    ++  +  P G
Sbjct: 2613 PITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTG 2651



 Score =  107 bits (267), Expect = 6e-23
 Identities = 163/753 (21%), Positives = 237/753 (31%), Gaps = 67/753 (8%)

Query: 122  TAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAP-PSTLSLPPKVPGQVTVTME--- 177
            T P    T   P     G   P   P   +  + P P P+    P   P   T T+    
Sbjct: 1898 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 1957

Query: 178  ----SSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRG 233
                +  P  + I   T       P+      TT +  +   +  P P      +  P  
Sbjct: 1958 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2017

Query: 234  AAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATV 293
                   + +   T    T+ +    T  P       Q   +  P+TT+  + P    T 
Sbjct: 2018 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTG 2076

Query: 294  SATRAQSPVITTTAAHATDSALSR--------PTLSIQHPPSAAISIQRPAQSRDVTTRI 345
            + T   +P+ TTT    T +             T +   P       Q P  +   TT  
Sbjct: 2077 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2136

Query: 346  TLPSHPALGT---PKQQLHTMAQKTIFSTGTPVAAATVAPILATNTI-PSATTAGSVSHT 401
              P+    GT       + T    T   T T     T  PI  T T+ P+ T  G+ + T
Sbjct: 2137 VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2196

Query: 402  QAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISG 461
              P +T  T+T     +     TT+ I     V    T T  +     P   ++ +    
Sbjct: 2197 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV---- 2252

Query: 462  HRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAH--TYTPITSSVS-TIRQYP 518
               +P P    T++     +         T  P+  P      T TPIT++ + T    P
Sbjct: 2253 ---TPTPTPTGTQTPTTTPITT-----TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2304

Query: 519  VSAQAPNSA-ITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIG 577
               Q P +  IT  T V    T      Q  T             P P  TQ     PI 
Sbjct: 2305 TGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2362

Query: 578  TPGI---QPAPLGTQGIHSATPINTQGL---QPAPMGTQQP--QPEGKTSAVVLADGATI 629
            T       P P GTQ   + TPI T       P P GTQ P   P   T+ V      T 
Sbjct: 2363 TTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2421

Query: 630  VANPISNPFSAAPAAT-TVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHV 688
               P + P +     T T   T +Q+ +T      ++  P+       T    P +    
Sbjct: 2422 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2481

Query: 689  SMATPVTVSMETVSNQNNDQPTIAVP---PTAQQPPPTIPTMIAAASPPSQPAVALSTIP 745
               TP     +T +       T   P   PT  Q P T P        P+       T  
Sbjct: 2482 VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-- 2539

Query: 746  GAVPITPPITTIAAAPP---------PSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRP 796
               P T PITT     P         P+ T   + ++V   P P         P+     
Sbjct: 2540 ---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2596

Query: 797  VSAVPPLATNTVSPSLALLANNLSMPTSDLPPG 829
            V+   P  T T +P+   +    ++  +  P G
Sbjct: 2597 VTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTG 2628



 Score =  104 bits (259), Expect = 5e-22
 Identities = 166/759 (21%), Positives = 237/759 (31%), Gaps = 65/759 (8%)

Query: 115  SATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAP-PSTLSLPPKVPGQVT 173
            + T    T P    T   P     G   P   P   +  + P P P+    P   P   T
Sbjct: 2167 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2226

Query: 174  VTME-------SSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIG 226
             T+        +  P  + I   T       P+      TT +  +   +  P P     
Sbjct: 2227 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2286

Query: 227  ASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIP 286
             +  P         + +   T    T+ +    T  P       Q   +  P+TT+  + 
Sbjct: 2287 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-PTTTPITTTTTVT 2345

Query: 287  PAVVATVSATRAQSPVITTTAAHATDSALSRPT--------LSIQHPPSAAISIQRPAQS 338
            P    T + T   +P+ TTT    T +     T         +   P       Q P  +
Sbjct: 2346 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2405

Query: 339  RDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSV 398
               TT    P+    GT   Q  T    T  +T TP    T      T  I + TT   V
Sbjct: 2406 PITTTTTVTPTPTPTGT---QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT---V 2459

Query: 399  SHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIP 458
            + T  PT T    T P  ++  T VT +  P     P     T+       P    +  P
Sbjct: 2460 TPTPTPTGTQTPTTTPITTT--TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2517

Query: 459  IS---GHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAH--TYTPITSSVS- 512
             +       +  P    T +    + P+       T  P+  P      T TPIT++ + 
Sbjct: 2518 TTTPITTTTTVTPTPTPTGTQTPTTTPIT---TTTTVTPTPTPTGTQTPTTTPITTTTTV 2574

Query: 513  TIRQYPVSAQAPNSA-ITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGI 571
            T    P   Q P +  IT  T V    T      Q  T             P P  TQ  
Sbjct: 2575 TPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPITTTTTVTPTPTPTGTQTP 2632

Query: 572  QPAPIGTPGI---QPAPLGTQGIHSATPINTQGL---QPAPMGTQQP--QPEGKTSAVVL 623
               PI T       P P GTQ   + TPI T       P P GTQ P   P   T+ V  
Sbjct: 2633 TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 2691

Query: 624  ADGATIVANPISNPFSAAPAAT-TVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKP 682
                T    P + P +     T T   T +Q+ +T      ++  P+       T    P
Sbjct: 2692 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2751

Query: 683  KSEIHVSMATPVTVSMETVSNQNNDQPTIAVP---PTAQQPPPTIPTMIAAASPPSQPAV 739
             +       TP     +T +       T   P   PT  Q P T P        P+    
Sbjct: 2752 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2811

Query: 740  ALSTIPGAVPITPPITTIAAAPP---------PSVTVGGSLSSVLGPPVPEIKVKEEVEP 790
               T     P T PITT     P         P+ T   + ++V   P P         P
Sbjct: 2812 GTQT-----PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2866

Query: 791  MDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPG 829
            +     V+   P  T T +P+   +    ++  +  P G
Sbjct: 2867 ITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTG 2904



 Score =  104 bits (259), Expect = 5e-22
 Identities = 166/759 (21%), Positives = 237/759 (31%), Gaps = 65/759 (8%)

Query: 115  SATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAP-PSTLSLPPKVPGQVT 173
            + T    T P    T   P     G   P   P   +  + P P P+    P   P   T
Sbjct: 2604 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2663

Query: 174  VTME-------SSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIG 226
             T+        +  P  + I   T       P+      TT +  +   +  P P     
Sbjct: 2664 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2723

Query: 227  ASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIP 286
             +  P         + +   T    T+ +    T  P       Q   +  P+TT+  + 
Sbjct: 2724 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-PTTTPITTTTTVT 2782

Query: 287  PAVVATVSATRAQSPVITTTAAHATDSALSRPT--------LSIQHPPSAAISIQRPAQS 338
            P    T + T   +P+ TTT    T +     T         +   P       Q P  +
Sbjct: 2783 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2842

Query: 339  RDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSV 398
               TT    P+    GT   Q  T    T  +T TP    T      T  I + TT   V
Sbjct: 2843 PITTTTTVTPTPTPTGT---QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT---V 2896

Query: 399  SHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIP 458
            + T  PT T    T P  ++  T VT +  P     P     T+       P    +  P
Sbjct: 2897 TPTPTPTGTQTPTTTPITTT--TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2954

Query: 459  IS---GHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAH--TYTPITSSVS- 512
             +       +  P    T +    + P+       T  P+  P      T TPIT++ + 
Sbjct: 2955 TTTPITTTTTVTPTPTPTGTQTPTTTPIT---TTTTVTPTPTPTGTQTPTTTPITTTTTV 3011

Query: 513  TIRQYPVSAQAPNSA-ITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGI 571
            T    P   Q P +  IT  T V    T      Q  T             P P  TQ  
Sbjct: 3012 TPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPITTTTTVTPTPTPTGTQTP 3069

Query: 572  QPAPIGTPGI---QPAPLGTQGIHSATPINTQGL---QPAPMGTQQP--QPEGKTSAVVL 623
               PI T       P P GTQ   + TPI T       P P GTQ P   P   T+ V  
Sbjct: 3070 TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 3128

Query: 624  ADGATIVANPISNPFSAAPAAT-TVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKP 682
                T    P + P +     T T   T +Q+ +T      ++  P+       T    P
Sbjct: 3129 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3188

Query: 683  KSEIHVSMATPVTVSMETVSNQNNDQPTIAVP---PTAQQPPPTIPTMIAAASPPSQPAV 739
             +       TP     +T +       T   P   PT  Q P T P        P+    
Sbjct: 3189 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3248

Query: 740  ALSTIPGAVPITPPITTIAAAPP---------PSVTVGGSLSSVLGPPVPEIKVKEEVEP 790
               T     P T PITT     P         P+ T   + ++V   P P         P
Sbjct: 3249 GTQT-----PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3303

Query: 791  MDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPG 829
            +     V+   P  T T +P+   +    ++  +  P G
Sbjct: 3304 ITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTG 3341



 Score =  104 bits (259), Expect = 5e-22
 Identities = 166/759 (21%), Positives = 237/759 (31%), Gaps = 65/759 (8%)

Query: 115  SATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAP-PSTLSLPPKVPGQVT 173
            + T    T P    T   P     G   P   P   +  + P P P+    P   P   T
Sbjct: 3041 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3100

Query: 174  VTME-------SSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIG 226
             T+        +  P  + I   T       P+      TT +  +   +  P P     
Sbjct: 3101 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3160

Query: 227  ASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIP 286
             +  P         + +   T    T+ +    T  P       Q   +  P+TT+  + 
Sbjct: 3161 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-PTTTPITTTTTVT 3219

Query: 287  PAVVATVSATRAQSPVITTTAAHATDSALSRPT--------LSIQHPPSAAISIQRPAQS 338
            P    T + T   +P+ TTT    T +     T         +   P       Q P  +
Sbjct: 3220 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3279

Query: 339  RDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSV 398
               TT    P+    GT   Q  T    T  +T TP    T      T  I + TT   V
Sbjct: 3280 PITTTTTVTPTPTPTGT---QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT---V 3333

Query: 399  SHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIP 458
            + T  PT T    T P  ++  T VT +  P     P     T+       P    +  P
Sbjct: 3334 TPTPTPTGTQTPTTTPITTT--TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 3391

Query: 459  IS---GHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAH--TYTPITSSVS- 512
             +       +  P    T +    + P+       T  P+  P      T TPIT++ + 
Sbjct: 3392 TTTPITTTTTVTPTPTPTGTQTPTTTPIT---TTTTVTPTPTPTGTQTPTTTPITTTTTV 3448

Query: 513  TIRQYPVSAQAPNSA-ITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGI 571
            T    P   Q P +  IT  T V    T      Q  T             P P  TQ  
Sbjct: 3449 TPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPITTTTTVTPTPTPTGTQTP 3506

Query: 572  QPAPIGTPGI---QPAPLGTQGIHSATPINTQGL---QPAPMGTQQP--QPEGKTSAVVL 623
               PI T       P P GTQ   + TPI T       P P GTQ P   P   T+ V  
Sbjct: 3507 TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 3565

Query: 624  ADGATIVANPISNPFSAAPAAT-TVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKP 682
                T    P + P +     T T   T +Q+ +T      ++  P+       T    P
Sbjct: 3566 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3625

Query: 683  KSEIHVSMATPVTVSMETVSNQNNDQPTIAVP---PTAQQPPPTIPTMIAAASPPSQPAV 739
             +       TP     +T +       T   P   PT  Q P T P        P+    
Sbjct: 3626 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3685

Query: 740  ALSTIPGAVPITPPITTIAAAPP---------PSVTVGGSLSSVLGPPVPEIKVKEEVEP 790
               T     P T PITT     P         P+ T   + ++V   P P         P
Sbjct: 3686 GTQT-----PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3740

Query: 791  MDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPG 829
            +     V+   P  T T +P+   +    ++  +  P G
Sbjct: 3741 ITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTG 3778



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 173/787 (21%), Positives = 251/787 (31%), Gaps = 101/787 (12%)

Query: 95   PVVVRPYPQVQMLSTHHAVAS-ATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRP 153
            P+   P P    ++T     + ++P+  T  P+  T   P   +     P   P+ P+  
Sbjct: 1684 PITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTT 1743

Query: 154  IAPAPPSTLS-------LPPKVPGQVTVTMESSIPQASAIPVATISG--QQGHPSNLHHI 204
            +   PP+T S       LPP +         ++ P    +P+   +G    G P N H  
Sbjct: 1744 MTTLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTPTTPCVPLCNWTGWLDSGKP-NFHKP 1802

Query: 205  MTTNVQMSIIRSNAPGPPLHIGAS-----HLPRGAAAAAVMSSSKVTTVLRPTSQLPNAA 259
                  +  +    PG   +I         +P G     V+    V  + +   Q P   
Sbjct: 1803 GGDTELIGDVCG--PGWAANISCRATMYPDVPIGQLGQTVVCDVSVGLICKNEDQKPGGV 1860

Query: 260  TAQPAVQHI---------IHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHA 310
                   +          + QP  +    TT N  PP            +P+ TTT    
Sbjct: 1861 IPMAFCLNYEINVQCCECVTQPT-TMTTTTTENPTPPTT----------TPITTTTTVTP 1909

Query: 311  TDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFS 370
            T +    PT             Q P  +   TT    P+    GT   Q  T    T  +
Sbjct: 1910 TPT----PT-----------GTQTPTTTPITTTTTVTPTPTPTGT---QTPTTTPITTTT 1951

Query: 371  TGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPV 430
            T TP    T      T  I + TT   V+ T  PT T    T P  ++  T VT +  P 
Sbjct: 1952 TVTPTPTPTGTQTPTTTPITTTTT---VTPTPTPTGTQTPTTTPITTT--TTVTPTPTPT 2006

Query: 431  AKVVPQQITHTSPRIQPDYPAERSSLIPIS---GHRASPNPVAMETRSDNRPSVPVQFQY 487
                P     T+       P    +  P +       +  P    T +    + P+    
Sbjct: 2007 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT--- 2063

Query: 488  FLPTYPPSAYPLAAH--TYTPITSSVS-TIRQYPVSAQAPNSA-ITAQTGVGVASTVHLN 543
               T  P+  P      T TPIT++ + T    P   Q P +  IT  T V    T    
Sbjct: 2064 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--T 2121

Query: 544  PMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGI---QPAPLGTQGIHSATPINTQ 600
              Q  T             P P  TQ     PI T       P P GTQ   + TPI T 
Sbjct: 2122 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ-TPTTTPITTT 2180

Query: 601  GL---QPAPMGTQQP--QPEGKTSAVVLADGATIVANPISNPFSAAPAAT-TVVQTHSQS 654
                  P P GTQ P   P   T+ V      T    P + P +     T T   T +Q+
Sbjct: 2181 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2240

Query: 655  ASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVP 714
             +T      ++  P+       T    P +       TP     +T +       T   P
Sbjct: 2241 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 2300

Query: 715  ---PTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPP--------- 762
               PT  Q P T P        P+       T     P T PITT     P         
Sbjct: 2301 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----PTTTPITTTTTVTPTPTPTGTQT 2355

Query: 763  PSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMP 822
            P+ T   + ++V   P P         P+     V+   P  T T +P+   +    ++ 
Sbjct: 2356 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVT 2414

Query: 823  TSDLPPG 829
             +  P G
Sbjct: 2415 PTPTPTG 2421



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 142/642 (22%), Positives = 206/642 (32%), Gaps = 64/642 (9%)

Query: 231  PRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQP------IQSRPPVTTSNA 284
            P       + +++ VT    PT       T       +   P        +  P+TT+  
Sbjct: 1893 PTPPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 1952

Query: 285  IPPAVVATVSATRAQSPVITTTAAHATDSALSR--------PTLSIQHPPSAAISIQRPA 336
            + P    T + T   +P+ TTT    T +             T +   P       Q P 
Sbjct: 1953 VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2012

Query: 337  QSRDVTTRITLPSHPALGT---PKQQLHTMAQKTIFSTGTPVAAATVAPILATNTI-PSA 392
             +   TT    P+    GT       + T    T   T T     T  PI  T T+ P+ 
Sbjct: 2013 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2072

Query: 393  TTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAE 452
            T  G+ + T  P +T  T+T     +     TT+ I     V    T T  +     P  
Sbjct: 2073 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2132

Query: 453  RSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAH--TYTPITSS 510
             ++ +       +P P    T++     +         T  P+  P      T TPIT++
Sbjct: 2133 TTTTV-------TPTPTPTGTQTPTTTPITT-----TTTVTPTPTPTGTQTPTTTPITTT 2180

Query: 511  VS-TIRQYPVSAQAPNSA-ITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPIST 568
             + T    P   Q P +  IT  T V    T      Q  T             P P  T
Sbjct: 2181 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPITTTTTVTPTPTPTGT 2238

Query: 569  QGIQPAPIGTPGI---QPAPLGTQGIHSATPINTQGL---QPAPMGTQQP--QPEGKTSA 620
            Q     PI T       P P GTQ   + TPI T       P P GTQ P   P   T+ 
Sbjct: 2239 QTPTTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2297

Query: 621  VVLADGATIVANPISNPFSAAPAAT-TVVQTHSQSASTNAPAQGSSPRPSILRKKPATDG 679
            V      T    P + P +     T T   T +Q+ +T      ++  P+       T  
Sbjct: 2298 VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2357

Query: 680  AKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVP---PTAQQPPPTIPTMIAAASPPSQ 736
              P +       TP     +T +       T   P   PT  Q P T P        P+ 
Sbjct: 2358 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2417

Query: 737  PAVALSTIPGAVPITPPITTIAAAPP---------PSVTVGGSLSSVLGPPVPEIKVKEE 787
                  T     P T PITT     P         P+ T   + ++V   P P       
Sbjct: 2418 TPTGTQT-----PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2472

Query: 788  VEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPG 829
              P+     V+   P  T T +P+   +    ++  +  P G
Sbjct: 2473 TTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTG 2513



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 108/413 (26%), Positives = 148/413 (35%), Gaps = 35/413 (8%)

Query: 121  VTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSI 180
            +T P    T   P   S   + P   P+ P+      PP+T   PP     +T T     
Sbjct: 1396 ITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPP-----ITTTTTPPP 1450

Query: 181  PQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVM 240
                + P++T +     P+      TT        +  P PP     +  P         
Sbjct: 1451 TTTPSPPISTTTTPP--PTTTPSPPTTTPSPP---TTTPSPPTTTTTTPPP------TTT 1499

Query: 241  SSSKVTTVLRP---TSQLPNAATAQPAVQHIIHQPIQSRP-PVTTSNAIPPAVVATVSAT 296
             S   TT + P   T+ LP   T  P        P  + P P TT+   PP    T+  T
Sbjct: 1500 PSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPT 1559

Query: 297  RAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQS-RDVTTRITLPSHPALGT 355
               SP  TTT      +  S PT +   PP+   +   P  +    TT  T P  P   T
Sbjct: 1560 TTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTP--PPTTT 1617

Query: 356  PKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTV-P 414
            P     T       +T  P    T +P   T T P  TT  S   T  P+  I T T  P
Sbjct: 1618 PSPPTTTPITPPTSTTTLP-PTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPP 1676

Query: 415  SHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETR 474
              ++ ++ +TT+  P        +T  SP   P  P   ++  P S    SP P  M T 
Sbjct: 1677 PTTTPSSPITTTPSPPTTT----MTTPSPTTTPSSPI-TTTTTPSSTTTPSPPPTTMTTP 1731

Query: 475  S-DNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNS 526
            S    PS P      LP    S+ PL   T TP+  S++     P S   P +
Sbjct: 1732 SPTTTPSPPTTTMTTLPPTTTSS-PL---TTTPLPPSITPPTFSPFSTTTPTT 1780



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 109/444 (24%), Positives = 153/444 (34%), Gaps = 81/444 (18%)

Query: 316  SRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPV 375
            S PT +   PP++  ++         TT  T P  P   TP   + T        T TP 
Sbjct: 1400 SPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTP--PPTTTPSPPITT--------TTTPP 1449

Query: 376  AAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVP 435
               T +P ++T T P  TT  S   T  P+    T + P      T  TT+  P     P
Sbjct: 1450 PTTTPSPPISTTTTPPPTTTPSPP-TTTPSPPTTTPSPP------TTTTTTPPPTTTPSP 1502

Query: 436  QQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPS 495
               T  +P      PA  ++L P +    +P+P    T                 T PP+
Sbjct: 1503 PTTTPITP------PASTTTLPPTT----TPSPPTTTTT----------------TPPPT 1536

Query: 496  AYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQ----TGVGVASTVHLNPMQLMTVD 551
              P +  T TPIT   ST    P +  +P    T      T     +T   +P  + T  
Sbjct: 1537 TTP-SPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTT 1595

Query: 552  ASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPIN--TQGLQPAPMGT 609
                       P P +T    P+P  T    P P  T    + TPI   T      P  T
Sbjct: 1596 -----------PPPTTT----PSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTT 1640

Query: 610  QQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPS 669
              P P   T+        T   +P +    + P  TT     + + S+      S P  +
Sbjct: 1641 PSPPPTTTTTPP-----PTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTT 1695

Query: 670  ILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIA 729
            +    P T  + P       + T  T S  T  +      T   P T   PP T  T + 
Sbjct: 1696 MTTPSPTTTPSSP-------ITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTL- 1747

Query: 730  AASPPSQPAVALSTIPGAVPITPP 753
               PP+  +  L+T P    ITPP
Sbjct: 1748 ---PPTTTSSPLTTTPLPPSITPP 1768



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 111/489 (22%), Positives = 159/489 (32%), Gaps = 69/489 (14%)

Query: 115  SATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAP-PSTLSLPPKVPGQVT 173
            + T    T P    T   P     G   P   P   +  + P P P+    P   P   T
Sbjct: 3892 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3951

Query: 174  VTME-------SSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIG 226
             T+        +  P  + I   T       P+      TT +  +   +  P P     
Sbjct: 3952 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 4011

Query: 227  ASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIP 286
             +  P         + +   T    T+ +    T  P       Q   +  P+TT+  + 
Sbjct: 4012 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-PTTTPITTTTTVT 4070

Query: 287  PAVVATVSATRAQSPVITTTAAHATDSALSRPT--------LSIQHPPSAAISIQRPAQS 338
            P    T + T   +P+ TTT    T +     T         +   P       Q P  +
Sbjct: 4071 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 4130

Query: 339  RDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSV 398
               TT    P+    GT   Q  T    T  +T TP    T      T  I + TT   V
Sbjct: 4131 PITTTTTVTPTPTPTGT---QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT---V 4184

Query: 399  SHTQAPTSTIVTMTVPSHSSHA--TAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSL 456
            + T  PT T      P+H+S A    +TTSN P     PQ    TS  +      E ++L
Sbjct: 4185 TPTPTPTGT--QTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPL-----TESTTL 4237

Query: 457  IPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQ 516
            +       S  P A+E  S   PS P                    T    TS   T+  
Sbjct: 4238 L-------STLPPAIEMTSTAPPSTP--------------------TAPTTTSGGHTLSP 4270

Query: 517  YPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPI 576
             P +  +P    T  T  G +S    + +Q  T  A          P P+ST    P+ I
Sbjct: 4271 PPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAWTP------TPTPLST----PSII 4320

Query: 577  GTPGIQPAP 585
             T G++P P
Sbjct: 4321 RTTGLRPYP 4329



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 89/382 (23%), Positives = 122/382 (31%), Gaps = 55/382 (14%)

Query: 490  PTYPPSAYPLAAHTYTPIT--SSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQL 547
            PT  PS  P +  T  P T  S  +T    P     P+  IT  T     +T        
Sbjct: 1402 PTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTT 1461

Query: 548  MTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPM 607
             T   +         P+P +T    P+P  T    P P  T    + TPI          
Sbjct: 1462 TTPPPTTTPSPPTTTPSPPTTT---PSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLP 1518

Query: 608  GTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPR 667
             T  P P   T         T    P + P   +P  TT + T   S +T  P    SP 
Sbjct: 1519 PTTTPSPPTTT---------TTTPPPTTTP---SPPTTTPI-TPPTSTTTLPPTTTPSPP 1565

Query: 668  PSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQP------- 720
            P+     P T    P +    S  T  T +    +  +    T   PP    P       
Sbjct: 1566 PTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTP 1625

Query: 721  --PPTIPTMIAAASPPSQPAVALSTIPGAVPITPPIT-------TIAAAPPPSVTVGGSL 771
              PPT  T +   + PS P    +T P     +PP T       T    PPP+ T    +
Sbjct: 1626 ITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPI 1685

Query: 772  SSVLGPP-----------VPEIKVKEEVEPMDIMR----PVSAVPPLATNTVSP------ 810
            ++   PP            P   +     P         P +   P  T T SP      
Sbjct: 1686 TTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMT 1745

Query: 811  SLALLANNLSMPTSDLPPGASP 832
            +L     +  + T+ LPP  +P
Sbjct: 1746 TLPPTTTSSPLTTTPLPPSITP 1767



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 48/211 (22%), Positives = 73/211 (34%), Gaps = 11/211 (5%)

Query: 628  TIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIH 687
            T  + P + P     + TT+  T + S  T      ++P P+     P T    P     
Sbjct: 1397 TTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTT---TTPPPTTTPSPPITTTTTPPPTTT 1453

Query: 688  VSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGA 747
             S     T +    +  +    T + P T   PP T  T     + PS P     T P +
Sbjct: 1454 PSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPAS 1513

Query: 748  VPITPPI------TTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVP 801
                PP       TT    PPP+ T     ++ + PP     +     P     P +   
Sbjct: 1514 TTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSP--PPTTTTT 1571

Query: 802  PLATNTVSPSLALLANNLSMPTSDLPPGASP 832
            P  T T SP      +  ++ T+  PP  +P
Sbjct: 1572 PPPTTTPSPPTTTTPSPPTITTTTPPPTTTP 1602



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 36/147 (24%), Positives = 51/147 (34%), Gaps = 7/147 (4%)

Query: 724  IPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGP-----P 778
            I T     + PS P  + +T+P     +PP TT    PPP+ T    +++   P     P
Sbjct: 1396 ITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTT-TTPPPTTTPSPPITTTTTPPPTTTP 1454

Query: 779  VPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRK 838
             P I       P     P +  P   T T SP            T+  PP  +P   P  
Sbjct: 1455 SPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPP-TTTTTTPPPTTTPSPPTTTPITPPAS 1513

Query: 839  QQHVISTEEGDMMETNSTDDEKSTAKS 865
               +  T       T +T    +T  S
Sbjct: 1514 TTTLPPTTTPSPPTTTTTTPPPTTTPS 1540


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score =  116 bits (291), Expect = 1e-25
 Identities = 182/872 (20%), Positives = 290/872 (33%), Gaps = 100/872 (11%)

Query: 38  PSTGLSQAPSQIANSGSAGLINPAATVNDES---GRDSEVSAREHMSSSSSLQSREEKQE 94
           P++  S+  S   N  +        T N ++   G++   SA+E  S   +         
Sbjct: 132 PNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTS 191

Query: 95  PVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPI 154
            V+ +P P+ +  +T    A  TP      P   TP  P S +     P    + P+ P 
Sbjct: 192 KVLAKPTPKAE--TTTKGPALTTP----KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPK 245

Query: 155 APAPPSTLSLP--PKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMS 212
            PAP +T S P  PK P   T    +        P  T   ++  P+      TT  + +
Sbjct: 246 EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT---KEPAPTTTKSAPTTPKEPA 302

Query: 213 IIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQP 272
                 P P         P+  A     ++ K  T   P    P      P         
Sbjct: 303 PTTPKKPAPT-------TPKEPAP----TTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT 351

Query: 273 IQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISI 332
              +P  TT     P      + T  + P  TT    A  +  S PT + +  P+   S 
Sbjct: 352 APKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSA 411

Query: 333 QRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSA 392
               +    TT       PA  TPK+   T  +K       P      AP       P+ 
Sbjct: 412 PTTPKEPSPTT----TKEPAPTTPKEPAPTTPKKP-----APTTPKEPAPTTPKEPAPTT 462

Query: 393 TTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSP-RIQPDYPA 451
           T   + +  + P  T    T P+     T  T   +  A   P++   T+P  + P  P 
Sbjct: 463 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKL--APTTPEKPAPTTPEELAPTTPE 520

Query: 452 ERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSV 511
           E +   P      +P   A  T  +  P+ P +     P  P    P      TP  ++ 
Sbjct: 521 EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAP 580

Query: 512 STIRQ-YPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQG 570
           +T+++  P + + P                   P +L              +PAP + +G
Sbjct: 581 TTLKEPAPTTPKKP------------------APKELAPTTTKEPTSTTCDKPAPTTPKG 622

Query: 571 IQPA----PIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADG 626
             P     P  T   +PAP   +G    T       +PAP   ++P P  K  A     G
Sbjct: 623 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTL-----KEPAPTTPKKPAP--KELAPTTTKG 675

Query: 627 ATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEI 686
            T       +  S  PA TT  +T   +    AP     P P+     P T         
Sbjct: 676 PT-------STTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS------- 721

Query: 687 HVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPG 746
              ++TP T    T  +++ D+ T   P  + +P P      A  + P +P V  +  P 
Sbjct: 722 --EVSTPTTTKEPTTIHKSPDEST---PELSAEPTPK-----ALENSPKEPGVPTTKTPA 771

Query: 747 AVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATN 806
           A    P +TT A        +  +  +    P    +     E     +  +    + + 
Sbjct: 772 AT--KPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 829

Query: 807 TVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSL 866
           T   +       L   T+ L P  +  KK      +++  E    ET    D  + +K+ 
Sbjct: 830 TTQDTTPFKITTLK--TTTLAPKVTTTKKTITTTEIMNKPE----ETAKPKDRATNSKAT 883

Query: 867 LVKAEKRKSPPKEYIDEEGVRYVPVRPRPPIT 898
             K +K    PK+    +  + +P R R P T
Sbjct: 884 TPKPQKPTKAPKKPTSTKKPKTMP-RVRKPKT 914



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 112/489 (22%), Positives = 166/489 (33%), Gaps = 44/489 (8%)

Query: 369 FSTGTPVAAATVAPILATNTIPSATTAGSVSHT-----QAPTSTIVTMTVPSHSSHATAV 423
           F   TP  + T    ++T+  P  TTA  ++        + TS   ++TV   ++  T  
Sbjct: 97  FKVTTPDTSTTQHNKVSTS--PKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKE 154

Query: 424 TTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPV 483
           TT+         ++ T ++   Q         L P S   A P P A  T      + P 
Sbjct: 155 TTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPK 214

Query: 484 QFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLN 543
           +     P  P S         TP   + +TI+  P + + P     A T    A T    
Sbjct: 215 EPTPTTPKEPAST--------TPKEPTPTTIKSAPTTPKEP-----APTTTKSAPTTPKE 261

Query: 544 PMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGI-----QPAPLGTQGIHSATPIN 598
           P    T + +     +   PAP +T+  +PAP  T        +PAP   +     TP  
Sbjct: 262 PAPTTTKEPAPTTPKE---PAPTTTK--EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE 316

Query: 599 ---TQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAA-PAATTVVQTHSQS 654
              T   +P P   ++P P  K  A          A     P +   PA TT  +    +
Sbjct: 317 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 376

Query: 655 ASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVP 714
               +P     P P+  +  P T      +    +  TP   S  T        P    P
Sbjct: 377 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 436

Query: 715 PTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITP----PITTIAAAPPPSVTVGGS 770
            T ++P PT P    A + P +PA   +  P   P TP    P T    AP     +  +
Sbjct: 437 TTPKKPAPTTPKE-PAPTTPKEPAPTTTKKP--APTTPKEPAPTTPKETAPTTPKKLTPT 493

Query: 771 LSSVLGPPVPE---IKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLP 827
               L P  PE       EE+ P     P    P     T   + A        PT+   
Sbjct: 494 TPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 553

Query: 828 PGASPRKKP 836
           P  +  K+P
Sbjct: 554 PAPTTPKEP 562



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 128/598 (21%), Positives = 185/598 (30%), Gaps = 91/598 (15%)

Query: 33   PRLGAPSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEK 92
            P   AP+T    AP+            P  T  +E    +  +A  +     +  + +E 
Sbjct: 495  PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP 554

Query: 93   QEPVVVRPYPQVQMLSTHHAVASATPVAVTAP-----PAHLTPA--VPLSFSEGLMKPP- 144
                   P P     +T    A  TP   TAP     PA  TP    P   +    K P 
Sbjct: 555  APTTPKEPAP-----TTPKETAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 608

Query: 145  -----------PKPTMPSRPIAPAPPSTLSLPPKVP-GQVTVTMESSIPQASAIPVATIS 192
                       PK T P+ P  PAP +     P  P G    T++   P     P     
Sbjct: 609  STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA---- 664

Query: 193  GQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRP- 251
                 P  L    T     +     AP  P    A   P+  A       +  T    P 
Sbjct: 665  -----PKELAPTTTKGPTSTTSDKPAPTTPKET-APTTPKEPAPTTPKKPAPTTPETPPP 718

Query: 252  -TSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAV--------VATVSATRAQSPV 302
             TS++    T +      IH+      P  ++   P A+        V T     A  P 
Sbjct: 719  TTSEVSTPTTTKEPTT--IHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPE 776

Query: 303  ITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHT 362
            +TTTA   T     R T      P    +  +  +    TT  T  S     T  Q   T
Sbjct: 777  MTTTAKDKTTERDLRTT------PETTTAAPKMTKETATTTEKTTESK-ITATTTQVTST 829

Query: 363  MAQKTIFSTGTPVAAATVAPILATN--TIPSATTAGSVSHTQAP----TSTIVTMTVPSH 416
              Q T     T +   T+AP + T   TI +         T  P    T++  T   P  
Sbjct: 830  TTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQK 889

Query: 417  SSHATAVTTSNI----------PVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASP 466
             + A    TS            P     P+++T T P + P      + L   +    +P
Sbjct: 890  PTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTP 949

Query: 467  NPVAMETRSDNR---------PSVPVQFQYFLPTYPPS-----AYPLAAHTYTPITSSVS 512
            N   +E    +          P + ++   F+P   P        P       P+ S  +
Sbjct: 950  NSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDET 1009

Query: 513  TIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQ--PAPIST 568
             I     + +  +   T + G  VA   H   M       S AR I  +   P+PI T
Sbjct: 1010 NI----CNGKPVDGLTTLRNGTLVAFRGHYFWMLSPFSPPSPARRITEVWGIPSPIDT 1063


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score =  116 bits (291), Expect = 1e-25
 Identities = 182/872 (20%), Positives = 290/872 (33%), Gaps = 100/872 (11%)

Query: 38  PSTGLSQAPSQIANSGSAGLINPAATVNDES---GRDSEVSAREHMSSSSSLQSREEKQE 94
           P++  S+  S   N  +        T N ++   G++   SA+E  S   +         
Sbjct: 173 PNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTS 232

Query: 95  PVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPI 154
            V+ +P P+ +  +T    A  TP      P   TP  P S +     P    + P+ P 
Sbjct: 233 KVLAKPTPKAE--TTTKGPALTTP----KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPK 286

Query: 155 APAPPSTLSLP--PKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMS 212
            PAP +T S P  PK P   T    +        P  T   ++  P+      TT  + +
Sbjct: 287 EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT---KEPAPTTTKSAPTTPKEPA 343

Query: 213 IIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQP 272
                 P P         P+  A     ++ K  T   P    P      P         
Sbjct: 344 PTTPKKPAPT-------TPKEPAP----TTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT 392

Query: 273 IQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISI 332
              +P  TT     P      + T  + P  TT    A  +  S PT + +  P+   S 
Sbjct: 393 APKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSA 452

Query: 333 QRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSA 392
               +    TT       PA  TPK+   T  +K       P      AP       P+ 
Sbjct: 453 PTTPKEPSPTT----TKEPAPTTPKEPAPTTPKKP-----APTTPKEPAPTTPKEPAPTT 503

Query: 393 TTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSP-RIQPDYPA 451
           T   + +  + P  T    T P+     T  T   +  A   P++   T+P  + P  P 
Sbjct: 504 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKL--APTTPEKPAPTTPEELAPTTPE 561

Query: 452 ERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSV 511
           E +   P      +P   A  T  +  P+ P +     P  P    P      TP  ++ 
Sbjct: 562 EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAP 621

Query: 512 STIRQ-YPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQG 570
           +T+++  P + + P                   P +L              +PAP + +G
Sbjct: 622 TTLKEPAPTTPKKP------------------APKELAPTTTKEPTSTTCDKPAPTTPKG 663

Query: 571 IQPA----PIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADG 626
             P     P  T   +PAP   +G    T       +PAP   ++P P  K  A     G
Sbjct: 664 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTL-----KEPAPTTPKKPAP--KELAPTTTKG 716

Query: 627 ATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEI 686
            T       +  S  PA TT  +T   +    AP     P P+     P T         
Sbjct: 717 PT-------STTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS------- 762

Query: 687 HVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPG 746
              ++TP T    T  +++ D+ T   P  + +P P      A  + P +P V  +  P 
Sbjct: 763 --EVSTPTTTKEPTTIHKSPDEST---PELSAEPTPK-----ALENSPKEPGVPTTKTPA 812

Query: 747 AVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATN 806
           A    P +TT A        +  +  +    P    +     E     +  +    + + 
Sbjct: 813 AT--KPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 870

Query: 807 TVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSL 866
           T   +       L   T+ L P  +  KK      +++  E    ET    D  + +K+ 
Sbjct: 871 TTQDTTPFKITTLK--TTTLAPKVTTTKKTITTTEIMNKPE----ETAKPKDRATNSKAT 924

Query: 867 LVKAEKRKSPPKEYIDEEGVRYVPVRPRPPIT 898
             K +K    PK+    +  + +P R R P T
Sbjct: 925 TPKPQKPTKAPKKPTSTKKPKTMP-RVRKPKT 955



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 112/489 (22%), Positives = 166/489 (33%), Gaps = 44/489 (8%)

Query: 369 FSTGTPVAAATVAPILATNTIPSATTAGSVSHT-----QAPTSTIVTMTVPSHSSHATAV 423
           F   TP  + T    ++T+  P  TTA  ++        + TS   ++TV   ++  T  
Sbjct: 138 FKVTTPDTSTTQHNKVSTS--PKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKE 195

Query: 424 TTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPV 483
           TT+         ++ T ++   Q         L P S   A P P A  T      + P 
Sbjct: 196 TTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPK 255

Query: 484 QFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLN 543
           +     P  P S         TP   + +TI+  P + + P     A T    A T    
Sbjct: 256 EPTPTTPKEPAST--------TPKEPTPTTIKSAPTTPKEP-----APTTTKSAPTTPKE 302

Query: 544 PMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGI-----QPAPLGTQGIHSATPIN 598
           P    T + +     +   PAP +T+  +PAP  T        +PAP   +     TP  
Sbjct: 303 PAPTTTKEPAPTTPKE---PAPTTTK--EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE 357

Query: 599 ---TQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAA-PAATTVVQTHSQS 654
              T   +P P   ++P P  K  A          A     P +   PA TT  +    +
Sbjct: 358 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 417

Query: 655 ASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVP 714
               +P     P P+  +  P T      +    +  TP   S  T        P    P
Sbjct: 418 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 477

Query: 715 PTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITP----PITTIAAAPPPSVTVGGS 770
            T ++P PT P    A + P +PA   +  P   P TP    P T    AP     +  +
Sbjct: 478 TTPKKPAPTTPKE-PAPTTPKEPAPTTTKKP--APTTPKEPAPTTPKETAPTTPKKLTPT 534

Query: 771 LSSVLGPPVPE---IKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLP 827
               L P  PE       EE+ P     P    P     T   + A        PT+   
Sbjct: 535 TPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 594

Query: 828 PGASPRKKP 836
           P  +  K+P
Sbjct: 595 PAPTTPKEP 603



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 128/598 (21%), Positives = 185/598 (30%), Gaps = 91/598 (15%)

Query: 33   PRLGAPSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEK 92
            P   AP+T    AP+            P  T  +E    +  +A  +     +  + +E 
Sbjct: 536  PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP 595

Query: 93   QEPVVVRPYPQVQMLSTHHAVASATPVAVTAP-----PAHLTPA--VPLSFSEGLMKPP- 144
                   P P     +T    A  TP   TAP     PA  TP    P   +    K P 
Sbjct: 596  APTTPKEPAP-----TTPKETAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 649

Query: 145  -----------PKPTMPSRPIAPAPPSTLSLPPKVP-GQVTVTMESSIPQASAIPVATIS 192
                       PK T P+ P  PAP +     P  P G    T++   P     P     
Sbjct: 650  STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA---- 705

Query: 193  GQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRP- 251
                 P  L    T     +     AP  P    A   P+  A       +  T    P 
Sbjct: 706  -----PKELAPTTTKGPTSTTSDKPAPTTPKET-APTTPKEPAPTTPKKPAPTTPETPPP 759

Query: 252  -TSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAV--------VATVSATRAQSPV 302
             TS++    T +      IH+      P  ++   P A+        V T     A  P 
Sbjct: 760  TTSEVSTPTTTKEPTT--IHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPE 817

Query: 303  ITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHT 362
            +TTTA   T     R T      P    +  +  +    TT  T  S     T  Q   T
Sbjct: 818  MTTTAKDKTTERDLRTT------PETTTAAPKMTKETATTTEKTTESK-ITATTTQVTST 870

Query: 363  MAQKTIFSTGTPVAAATVAPILATN--TIPSATTAGSVSHTQAP----TSTIVTMTVPSH 416
              Q T     T +   T+AP + T   TI +         T  P    T++  T   P  
Sbjct: 871  TTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQK 930

Query: 417  SSHATAVTTSNI----------PVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASP 466
             + A    TS            P     P+++T T P + P      + L   +    +P
Sbjct: 931  PTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTP 990

Query: 467  NPVAMETRSDNR---------PSVPVQFQYFLPTYPPS-----AYPLAAHTYTPITSSVS 512
            N   +E    +          P + ++   F+P   P        P       P+ S  +
Sbjct: 991  NSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDET 1050

Query: 513  TIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQ--PAPIST 568
             I     + +  +   T + G  VA   H   M       S AR I  +   P+PI T
Sbjct: 1051 NI----CNGKPVDGLTTLRNGTLVAFRGHYFWMLSPFSPPSPARRITEVWGIPSPIDT 1104


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score =  116 bits (291), Expect = 1e-25
 Identities = 182/872 (20%), Positives = 290/872 (33%), Gaps = 100/872 (11%)

Query: 38   PSTGLSQAPSQIANSGSAGLINPAATVNDES---GRDSEVSAREHMSSSSSLQSREEKQE 94
            P++  S+  S   N  +        T N ++   G++   SA+E  S   +         
Sbjct: 225  PNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTS 284

Query: 95   PVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPI 154
             V+ +P P+ +  +T    A  TP      P   TP  P S +     P    + P+ P 
Sbjct: 285  KVLAKPTPKAE--TTTKGPALTTP----KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPK 338

Query: 155  APAPPSTLSLP--PKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMS 212
             PAP +T S P  PK P   T    +        P  T   ++  P+      TT  + +
Sbjct: 339  EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT---KEPAPTTTKSAPTTPKEPA 395

Query: 213  IIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQP 272
                  P P         P+  A     ++ K  T   P    P      P         
Sbjct: 396  PTTPKKPAPT-------TPKEPAP----TTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT 444

Query: 273  IQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISI 332
               +P  TT     P      + T  + P  TT    A  +  S PT + +  P+   S 
Sbjct: 445  APKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSA 504

Query: 333  QRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSA 392
                +    TT       PA  TPK+   T  +K       P      AP       P+ 
Sbjct: 505  PTTPKEPSPTT----TKEPAPTTPKEPAPTTPKKP-----APTTPKEPAPTTPKEPAPTT 555

Query: 393  TTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSP-RIQPDYPA 451
            T   + +  + P  T    T P+     T  T   +  A   P++   T+P  + P  P 
Sbjct: 556  TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKL--APTTPEKPAPTTPEELAPTTPE 613

Query: 452  ERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSV 511
            E +   P      +P   A  T  +  P+ P +     P  P    P      TP  ++ 
Sbjct: 614  EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAP 673

Query: 512  STIRQ-YPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQG 570
            +T+++  P + + P                   P +L              +PAP + +G
Sbjct: 674  TTLKEPAPTTPKKP------------------APKELAPTTTKEPTSTTCDKPAPTTPKG 715

Query: 571  IQPA----PIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADG 626
              P     P  T   +PAP   +G    T       +PAP   ++P P  K  A     G
Sbjct: 716  TAPTTPKEPAPTTPKEPAPTTPKGTAPTTL-----KEPAPTTPKKPAP--KELAPTTTKG 768

Query: 627  ATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEI 686
             T       +  S  PA TT  +T   +    AP     P P+     P T         
Sbjct: 769  PT-------STTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS------- 814

Query: 687  HVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPG 746
               ++TP T    T  +++ D+ T   P  + +P P      A  + P +P V  +  P 
Sbjct: 815  --EVSTPTTTKEPTTIHKSPDEST---PELSAEPTPK-----ALENSPKEPGVPTTKTPA 864

Query: 747  AVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATN 806
            A    P +TT A        +  +  +    P    +     E     +  +    + + 
Sbjct: 865  AT--KPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 922

Query: 807  TVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSL 866
            T   +       L   T+ L P  +  KK      +++  E    ET    D  + +K+ 
Sbjct: 923  TTQDTTPFKITTLK--TTTLAPKVTTTKKTITTTEIMNKPE----ETAKPKDRATNSKAT 976

Query: 867  LVKAEKRKSPPKEYIDEEGVRYVPVRPRPPIT 898
              K +K    PK+    +  + +P R R P T
Sbjct: 977  TPKPQKPTKAPKKPTSTKKPKTMP-RVRKPKT 1007



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 112/489 (22%), Positives = 166/489 (33%), Gaps = 44/489 (8%)

Query: 369 FSTGTPVAAATVAPILATNTIPSATTAGSVSHT-----QAPTSTIVTMTVPSHSSHATAV 423
           F   TP  + T    ++T+  P  TTA  ++        + TS   ++TV   ++  T  
Sbjct: 190 FKVTTPDTSTTQHNKVSTS--PKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKE 247

Query: 424 TTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPV 483
           TT+         ++ T ++   Q         L P S   A P P A  T      + P 
Sbjct: 248 TTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPK 307

Query: 484 QFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLN 543
           +     P  P S         TP   + +TI+  P + + P     A T    A T    
Sbjct: 308 EPTPTTPKEPAST--------TPKEPTPTTIKSAPTTPKEP-----APTTTKSAPTTPKE 354

Query: 544 PMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGI-----QPAPLGTQGIHSATPIN 598
           P    T + +     +   PAP +T+  +PAP  T        +PAP   +     TP  
Sbjct: 355 PAPTTTKEPAPTTPKE---PAPTTTK--EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE 409

Query: 599 ---TQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAA-PAATTVVQTHSQS 654
              T   +P P   ++P P  K  A          A     P +   PA TT  +    +
Sbjct: 410 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 469

Query: 655 ASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVP 714
               +P     P P+  +  P T      +    +  TP   S  T        P    P
Sbjct: 470 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 529

Query: 715 PTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITP----PITTIAAAPPPSVTVGGS 770
            T ++P PT P    A + P +PA   +  P   P TP    P T    AP     +  +
Sbjct: 530 TTPKKPAPTTPKE-PAPTTPKEPAPTTTKKP--APTTPKEPAPTTPKETAPTTPKKLTPT 586

Query: 771 LSSVLGPPVPE---IKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLP 827
               L P  PE       EE+ P     P    P     T   + A        PT+   
Sbjct: 587 TPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 646

Query: 828 PGASPRKKP 836
           P  +  K+P
Sbjct: 647 PAPTTPKEP 655



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 128/598 (21%), Positives = 185/598 (30%), Gaps = 91/598 (15%)

Query: 33   PRLGAPSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEK 92
            P   AP+T    AP+            P  T  +E    +  +A  +     +  + +E 
Sbjct: 588  PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP 647

Query: 93   QEPVVVRPYPQVQMLSTHHAVASATPVAVTAP-----PAHLTPA--VPLSFSEGLMKPP- 144
                   P P     +T    A  TP   TAP     PA  TP    P   +    K P 
Sbjct: 648  APTTPKEPAP-----TTPKETAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 701

Query: 145  -----------PKPTMPSRPIAPAPPSTLSLPPKVP-GQVTVTMESSIPQASAIPVATIS 192
                       PK T P+ P  PAP +     P  P G    T++   P     P     
Sbjct: 702  STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA---- 757

Query: 193  GQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRP- 251
                 P  L    T     +     AP  P    A   P+  A       +  T    P 
Sbjct: 758  -----PKELAPTTTKGPTSTTSDKPAPTTPKET-APTTPKEPAPTTPKKPAPTTPETPPP 811

Query: 252  -TSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAV--------VATVSATRAQSPV 302
             TS++    T +      IH+      P  ++   P A+        V T     A  P 
Sbjct: 812  TTSEVSTPTTTKEPTT--IHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPE 869

Query: 303  ITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHT 362
            +TTTA   T     R T      P    +  +  +    TT  T  S     T  Q   T
Sbjct: 870  MTTTAKDKTTERDLRTT------PETTTAAPKMTKETATTTEKTTESK-ITATTTQVTST 922

Query: 363  MAQKTIFSTGTPVAAATVAPILATN--TIPSATTAGSVSHTQAP----TSTIVTMTVPSH 416
              Q T     T +   T+AP + T   TI +         T  P    T++  T   P  
Sbjct: 923  TTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQK 982

Query: 417  SSHATAVTTSNI----------PVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASP 466
             + A    TS            P     P+++T T P + P      + L   +    +P
Sbjct: 983  PTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTP 1042

Query: 467  NPVAMETRSDNR---------PSVPVQFQYFLPTYPPS-----AYPLAAHTYTPITSSVS 512
            N   +E    +          P + ++   F+P   P        P       P+ S  +
Sbjct: 1043 NSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDET 1102

Query: 513  TIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQ--PAPIST 568
             I     + +  +   T + G  VA   H   M       S AR I  +   P+PI T
Sbjct: 1103 NI----CNGKPVDGLTTLRNGTLVAFRGHYFWMLSPFSPPSPARRITEVWGIPSPIDT 1156


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score =  116 bits (291), Expect = 1e-25
 Identities = 182/872 (20%), Positives = 290/872 (33%), Gaps = 100/872 (11%)

Query: 38   PSTGLSQAPSQIANSGSAGLINPAATVNDES---GRDSEVSAREHMSSSSSLQSREEKQE 94
            P++  S+  S   N  +        T N ++   G++   SA+E  S   +         
Sbjct: 266  PNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTS 325

Query: 95   PVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPI 154
             V+ +P P+ +  +T    A  TP      P   TP  P S +     P    + P+ P 
Sbjct: 326  KVLAKPTPKAE--TTTKGPALTTP----KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPK 379

Query: 155  APAPPSTLSLP--PKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMS 212
             PAP +T S P  PK P   T    +        P  T   ++  P+      TT  + +
Sbjct: 380  EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT---KEPAPTTTKSAPTTPKEPA 436

Query: 213  IIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQP 272
                  P P         P+  A     ++ K  T   P    P      P         
Sbjct: 437  PTTPKKPAPT-------TPKEPAP----TTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT 485

Query: 273  IQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISI 332
               +P  TT     P      + T  + P  TT    A  +  S PT + +  P+   S 
Sbjct: 486  APKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSA 545

Query: 333  QRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSA 392
                +    TT       PA  TPK+   T  +K       P      AP       P+ 
Sbjct: 546  PTTPKEPSPTT----TKEPAPTTPKEPAPTTPKKP-----APTTPKEPAPTTPKEPAPTT 596

Query: 393  TTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSP-RIQPDYPA 451
            T   + +  + P  T    T P+     T  T   +  A   P++   T+P  + P  P 
Sbjct: 597  TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKL--APTTPEKPAPTTPEELAPTTPE 654

Query: 452  ERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSV 511
            E +   P      +P   A  T  +  P+ P +     P  P    P      TP  ++ 
Sbjct: 655  EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAP 714

Query: 512  STIRQ-YPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQG 570
            +T+++  P + + P                   P +L              +PAP + +G
Sbjct: 715  TTLKEPAPTTPKKP------------------APKELAPTTTKEPTSTTCDKPAPTTPKG 756

Query: 571  IQPA----PIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADG 626
              P     P  T   +PAP   +G    T       +PAP   ++P P  K  A     G
Sbjct: 757  TAPTTPKEPAPTTPKEPAPTTPKGTAPTTL-----KEPAPTTPKKPAP--KELAPTTTKG 809

Query: 627  ATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEI 686
             T       +  S  PA TT  +T   +    AP     P P+     P T         
Sbjct: 810  PT-------STTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS------- 855

Query: 687  HVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPG 746
               ++TP T    T  +++ D+ T   P  + +P P      A  + P +P V  +  P 
Sbjct: 856  --EVSTPTTTKEPTTIHKSPDEST---PELSAEPTPK-----ALENSPKEPGVPTTKTPA 905

Query: 747  AVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATN 806
            A    P +TT A        +  +  +    P    +     E     +  +    + + 
Sbjct: 906  AT--KPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 963

Query: 807  TVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSL 866
            T   +       L   T+ L P  +  KK      +++  E    ET    D  + +K+ 
Sbjct: 964  TTQDTTPFKITTLK--TTTLAPKVTTTKKTITTTEIMNKPE----ETAKPKDRATNSKAT 1017

Query: 867  LVKAEKRKSPPKEYIDEEGVRYVPVRPRPPIT 898
              K +K    PK+    +  + +P R R P T
Sbjct: 1018 TPKPQKPTKAPKKPTSTKKPKTMP-RVRKPKT 1048



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 112/489 (22%), Positives = 166/489 (33%), Gaps = 44/489 (8%)

Query: 369 FSTGTPVAAATVAPILATNTIPSATTAGSVSHT-----QAPTSTIVTMTVPSHSSHATAV 423
           F   TP  + T    ++T+  P  TTA  ++        + TS   ++TV   ++  T  
Sbjct: 231 FKVTTPDTSTTQHNKVSTS--PKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKE 288

Query: 424 TTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPV 483
           TT+         ++ T ++   Q         L P S   A P P A  T      + P 
Sbjct: 289 TTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPK 348

Query: 484 QFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLN 543
           +     P  P S         TP   + +TI+  P + + P     A T    A T    
Sbjct: 349 EPTPTTPKEPAST--------TPKEPTPTTIKSAPTTPKEP-----APTTTKSAPTTPKE 395

Query: 544 PMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGI-----QPAPLGTQGIHSATPIN 598
           P    T + +     +   PAP +T+  +PAP  T        +PAP   +     TP  
Sbjct: 396 PAPTTTKEPAPTTPKE---PAPTTTK--EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE 450

Query: 599 ---TQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAA-PAATTVVQTHSQS 654
              T   +P P   ++P P  K  A          A     P +   PA TT  +    +
Sbjct: 451 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 510

Query: 655 ASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVP 714
               +P     P P+  +  P T      +    +  TP   S  T        P    P
Sbjct: 511 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 570

Query: 715 PTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITP----PITTIAAAPPPSVTVGGS 770
            T ++P PT P    A + P +PA   +  P   P TP    P T    AP     +  +
Sbjct: 571 TTPKKPAPTTPKE-PAPTTPKEPAPTTTKKP--APTTPKEPAPTTPKETAPTTPKKLTPT 627

Query: 771 LSSVLGPPVPE---IKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLP 827
               L P  PE       EE+ P     P    P     T   + A        PT+   
Sbjct: 628 TPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 687

Query: 828 PGASPRKKP 836
           P  +  K+P
Sbjct: 688 PAPTTPKEP 696



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 128/598 (21%), Positives = 185/598 (30%), Gaps = 91/598 (15%)

Query: 33   PRLGAPSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEK 92
            P   AP+T    AP+            P  T  +E    +  +A  +     +  + +E 
Sbjct: 629  PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP 688

Query: 93   QEPVVVRPYPQVQMLSTHHAVASATPVAVTAP-----PAHLTPA--VPLSFSEGLMKPP- 144
                   P P     +T    A  TP   TAP     PA  TP    P   +    K P 
Sbjct: 689  APTTPKEPAP-----TTPKETAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 742

Query: 145  -----------PKPTMPSRPIAPAPPSTLSLPPKVP-GQVTVTMESSIPQASAIPVATIS 192
                       PK T P+ P  PAP +     P  P G    T++   P     P     
Sbjct: 743  STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA---- 798

Query: 193  GQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRP- 251
                 P  L    T     +     AP  P    A   P+  A       +  T    P 
Sbjct: 799  -----PKELAPTTTKGPTSTTSDKPAPTTPKET-APTTPKEPAPTTPKKPAPTTPETPPP 852

Query: 252  -TSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAV--------VATVSATRAQSPV 302
             TS++    T +      IH+      P  ++   P A+        V T     A  P 
Sbjct: 853  TTSEVSTPTTTKEPTT--IHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPE 910

Query: 303  ITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHT 362
            +TTTA   T     R T      P    +  +  +    TT  T  S     T  Q   T
Sbjct: 911  MTTTAKDKTTERDLRTT------PETTTAAPKMTKETATTTEKTTESK-ITATTTQVTST 963

Query: 363  MAQKTIFSTGTPVAAATVAPILATN--TIPSATTAGSVSHTQAP----TSTIVTMTVPSH 416
              Q T     T +   T+AP + T   TI +         T  P    T++  T   P  
Sbjct: 964  TTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQK 1023

Query: 417  SSHATAVTTSNI----------PVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASP 466
             + A    TS            P     P+++T T P + P      + L   +    +P
Sbjct: 1024 PTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTP 1083

Query: 467  NPVAMETRSDNR---------PSVPVQFQYFLPTYPPS-----AYPLAAHTYTPITSSVS 512
            N   +E    +          P + ++   F+P   P        P       P+ S  +
Sbjct: 1084 NSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDET 1143

Query: 513  TIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQ--PAPIST 568
             I     + +  +   T + G  VA   H   M       S AR I  +   P+PI T
Sbjct: 1144 NI----CNGKPVDGLTTLRNGTLVAFRGHYFWMLSPFSPPSPARRITEVWGIPSPIDT 1197


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 202/860 (23%), Positives = 313/860 (36%), Gaps = 127/860 (14%)

Query: 3   PPRHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINPAA 62
           P   P+AG   + G           +S + P    P++G  +      N+    + +P  
Sbjct: 71  PESAPRAGPTRSAG-----------TSSRNPASRPPASGRGERAPPAKNTSPGPVSSP-- 117

Query: 63  TVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVT 122
                 GR S  +    +       S EE          P+   LS      ++ P   T
Sbjct: 118 ------GRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGT 171

Query: 123 APPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQ 182
             PA    +       GL  P P P+   RP    P  ++S   +       T E S P 
Sbjct: 172 PSPAMARRSRAAGTEVGL--PRPAPSARPRPPTEGPRKSVSSASEHS-----TTEPS-PA 223

Query: 183 ASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSS 242
           A   P A   G    P++     +     S  RS   GP     A   PR A A      
Sbjct: 224 ARRRPSA--GGGLQRPASRSLSSSATPLSSPARS---GP----SARGTPR-APAHPSQPK 273

Query: 243 SKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPV-TTSNAIPPA--VVATVSATRAQ 299
            K    LRP    P    A PA+  +   P+ +  P  T +  +PP       + AT   
Sbjct: 274 PKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPP 333

Query: 300 SPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGT--PK 357
           SP + T    A  S  + P+L     P A      P+Q+    T   + + P+L T  P 
Sbjct: 334 SPPLATPLPLAPPSPSAPPSLQTLPSPPAT----PPSQAPPSMTTPPMQAPPSLQTIPPI 389

Query: 358 QQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSH-TQAPTSTIVTMTVPSH 416
           Q  H++   ++ +  +P+A +++    AT ++ S T   + S  T +P  T  ++T PS 
Sbjct: 390 QVPHSLTSPSLQAPPSPLALSSLQ---ATTSLGSPTLQATHSFLTMSPRQTQASLTSPSR 446

Query: 417 SSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSD 476
                         A   P      +P   P  P  ++SL P     +SP  +       
Sbjct: 447 P-------------ASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIH------ 487

Query: 477 NRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGV 536
                P+Q    L ++ P A PL++    P+ +  S     P S Q P +++T      +
Sbjct: 488 -----PLQALSSLASHSPQA-PLSSLIMPPLETQSSLA---PPSLQTPPASLTTPPLENL 538

Query: 537 ASTVHLNPMQLMTVDASHAR-HIQGIQ-PAPISTQGIQPAPIGTPGIQ-PAPLGTQGIHS 593
            S   L P  L T  A     H++    PAP   Q   P+P+ TP  + P+ + T    +
Sbjct: 539 PS---LAPPPLQTASAPLTTPHLETPPCPAPCPLQA-PPSPLTTPPPETPSSIATPPPQA 594

Query: 594 ATPINTQGLQP------APMGTQQPQPEGKTSAVVLADGATIVANPISNPFSA-APAATT 646
              + +  LQ       +P+ T  PQ     +   L    +  A+P  +P +  +P A  
Sbjct: 595 PPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPN 654

Query: 647 VVQTHSQSASTNAPAQGSSPRP-SILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQN 705
            +  H   A  + P       P S     P +  A P S+   S+A P            
Sbjct: 655 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP------------ 702

Query: 706 NDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALST----IPGAVPITPPITTIAAAP 761
                + VPP+    PP  P M  +A+PP Q    L+     +P + P +PP++  A  P
Sbjct: 703 ----PLQVPPS----PPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPP 754

Query: 762 P--PSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPL----ATNTVSPSLALL 815
           P  P +     L     PP   + +    +P     P  A PPL    +     P  A  
Sbjct: 755 PRVPPLLAAPPLQVPPSPPA-SLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPF 813

Query: 816 ANNLSMPTSDL---PPGASP 832
           + + S+P S L   PP A P
Sbjct: 814 SPSASLPMSPLATPPPQAPP 833



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 170/750 (22%), Positives = 266/750 (35%), Gaps = 106/750 (14%)

Query: 52  SGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPV-----VVRPYPQVQM 106
           S   GL  PA+     S       AR   S+  + ++     +P       +RP PQV  
Sbjct: 229 SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRP-PQVTP 287

Query: 107 LSTHHAVA----SATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTL 162
                A A    S++P+A  +P    T A P+   +    P P    PS P+A   P   
Sbjct: 288 PRKDAAPALGPLSSSPLATPSPSG--TKARPVPPPDNAATPLPATLPPSPPLATPLPLAP 345

Query: 163 SLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSN--APG 220
             P   P   T+    + P + A P  T    Q  PS L  I    V  S+   +  AP 
Sbjct: 346 PSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPS-LQTIPPIQVPHSLTSPSLQAPP 404

Query: 221 PPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVT 280
            PL + +        +  + ++    T+    +Q    + ++PA       P  S PP+ 
Sbjct: 405 SPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPA-----STPPDS-PPLQ 458

Query: 281 TSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRD 340
              ++P +     S + A SP+ +    H   +  S  + S Q P S+ I      QS  
Sbjct: 459 APLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSL 518

Query: 341 VTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSH 400
               +  P       P + L ++A   + +   P+      P L T   P+         
Sbjct: 519 APPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTT----PHLETPPCPAPCPL----- 569

Query: 401 TQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQP--DYPAERSSLIP 458
            QAP S + T    + SS AT    +  P A   P      SP + P    P +    + 
Sbjct: 570 -QAPPSPLTTPPPETPSSIATPPPQA--PPALASPPLQGLPSPPLSPLATPPPQAPPXLA 626

Query: 459 ISGHRASPNPVA------METRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVS 512
           +   +A P+P A      + T S   P+         P  PP + P+ A    P +  VS
Sbjct: 627 LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 686

Query: 513 TIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQ 572
                P  A    +A   Q      ++  ++P       A          P P++   +Q
Sbjct: 687 PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQA----------PPPLAAPPLQ 736

Query: 573 --PAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIV 630
             P+P  +P + P+        +  P     L  AP     P P            A++ 
Sbjct: 737 VPPSPPASPPMSPS--------ATPPPRVPPLLAAPPLQVPPSPP-----------ASLP 777

Query: 631 ANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVS- 689
            +P++ P   AP A   + T    A  + PA      P             P + + +S 
Sbjct: 778 MSPLAKPPPQAPPA---LATPPLQALPSPPASFPGQAPF-----------SPSASLPMSP 823

Query: 690 MATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGA-V 748
           +ATP   +   ++      P + VPP+    PP  PT+ A   PP+         PG   
Sbjct: 824 LATPPPQAPPVLA-----APLLQVPPS----PPASPTLQAPRRPPT---------PGPDT 865

Query: 749 PITPPITTIAAAPPPSVTVGGSLSSVLGPP 778
            ++ P  T+A AP P      S SS L  P
Sbjct: 866 SVSGPRLTLALAPGPPPPPSRSPSSTLSGP 895



 Score = 33.9 bits (76), Expect = 0.82
 Identities = 42/158 (26%), Positives = 56/158 (35%), Gaps = 21/158 (13%)

Query: 97  VVRPYPQVQ-MLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIA 155
           + +P PQ    L+T    A  +P A     A  +P+  L  S     PP  P + + P+ 
Sbjct: 781 LAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLL 840

Query: 156 PAPPS-----TLSLP--PKVPGQVTVTMESSI---------PQASAIPVATISGQQGHPS 199
             PPS     TL  P  P  PG  T      +         P  S  P +T+SG    P 
Sbjct: 841 QVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSG----PD 896

Query: 200 NLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAA 237
              H  +       +R    GP     AS  P    AA
Sbjct: 897 LAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAA 934


>gi|167736355 mucin 4 isoform a [Homo sapiens]
          Length = 5284

 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 179/793 (22%), Positives = 284/793 (35%), Gaps = 102/793 (12%)

Query: 113  VASATPVAVT---------APPAHLTPAVPLSFSEGLMKPPPKPTMPSR----PIAPAPP 159
            +++ATP+ VT           P H+T A  +S       P   P+  S     P+     
Sbjct: 971  ISNATPLPVTYASSASTGHTTPLHVTDASSVSTGHATPLPVTSPSSVSTGHTTPLPVTDT 1030

Query: 160  STLSLPPKVPGQVTVTMESSIPQASAIPVA-TISGQQGHPSNLHHIMTTNVQMSIIRSNA 218
            S+ S     P  VT    +S   ++ +PV  T S   GH + L     T++  +      
Sbjct: 1031 SSESTGHVTPLPVTSFSSASTGDSTPLPVTDTSSASTGHVTPLP---VTSLSSASTGDTT 1087

Query: 219  PGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPP 278
            P P     ++     A +  V  +S V+T    T+ LP   T+  +  H    P+     
Sbjct: 1088 PLPVTDTSSASTGH-ATSLPVTDTSSVST--GHTTPLPVTDTSSASTGHATSLPVTDTSS 1144

Query: 279  VTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQS 338
            V+T +  P  V    SA+  Q+  +  T+  +  +  + P L +  P SA+     P   
Sbjct: 1145 VSTGHTTPLHVTDASSASTGQATPLPVTSLSSVSTGDTTP-LPVTSPSSASTGHATPLLV 1203

Query: 339  RDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSV 398
             D ++  T        TP       +  T  +T  PV   + A    T  +P  T   S 
Sbjct: 1204 TDTSSAST-----GHATPLPVTDASSVSTDHATSLPVTIPSAASTGHTTPLP-VTDTSSA 1257

Query: 399  SHTQAPTSTIVTMTVPSHSSHATAV---TTSNIPVAKVVPQQITH-TSPRIQPDYPAERS 454
            S  QA TS +VT T    +   T +   +TS+     V P  +T  +S       P   +
Sbjct: 1258 STGQA-TSLLVTDTSSVSTGDTTPLPVTSTSSASTGHVTPLHVTSPSSASTGHATPLPVT 1316

Query: 455  SLIPISGHRASPNPVAMETRSDNRPSVP--------VQFQYFLPTYPPSAYPLAAHTYTP 506
            SL   S     P PV   + +    + P        V   +  P +   A   +    TP
Sbjct: 1317 SLSSASTGDTMPLPVTSPSSASTGDTTPLPVTDASSVSTGHTTPLHVTDASSASTGQATP 1376

Query: 507  IT----SSVSTIRQYPVSAQAPNSAITAQ------TGVGVASTVHLNPMQLM---TVDAS 553
            +     SSVST    P+   +P+SA T        T    AST H  P+ +    +V   
Sbjct: 1377 LPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDTSSASTGHATPLPVTDASSVSTD 1436

Query: 554  HARHIQGIQPAPISTQGIQPAPI----------------------GTPGIQPAPLGTQGI 591
            HA  +    P+  ST    P P+                       T    P P+ +   
Sbjct: 1437 HATSLPVTIPSAASTGHTTPLPVTDTSSASTGQATSLLVTDTSSVSTGDTTPLPVTSTSS 1496

Query: 592  HSA---TPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVV 648
             S    TP++      A  G   P P    S+    D   +   P+++P SA+   TT +
Sbjct: 1497 ASTGHVTPLHVTSPSSASTGHATPLPVTSLSSASTGDTMPL---PVTSPSSASTGDTTPL 1553

Query: 649  Q-THSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMA-----TPVTVSMETVS 702
              T + S ST      ++P P       +T    P      S A     TP+ V+  + +
Sbjct: 1554 PVTDASSVSTGH----TTPLPVTSPSSASTGHTTPLPVTDTSSASKGDTTPLPVTSPSSA 1609

Query: 703  NQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPI---TPPITTIAA 759
            +  +  P      ++     T P  +  AS       +LST   A P+   +P   +   
Sbjct: 1610 STGHTTPLPVTDTSSASTGDTTPLPVTNAS-------SLST-GHATPLHVTSPSSASTGH 1661

Query: 760  APPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNL 819
            A P  VT   S S+    P+P   +           PV+ V   +T   +P      +++
Sbjct: 1662 ATPLPVTSTSSASTGHATPLPVTGLSSATTDDTTRLPVTDVSSASTGQATPLPVTSLSSV 1721

Query: 820  SMPTSDLPPGASP 832
            S   +   P  SP
Sbjct: 1722 STGDTTPLPVTSP 1734



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 190/878 (21%), Positives = 307/878 (34%), Gaps = 124/878 (14%)

Query: 51   NSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTH 110
            +S S G   P   V D S   +  +   H++S SS  + +    PV          +ST 
Sbjct: 3175 SSVSTGHATPLL-VTDASSASTGHATPLHVTSPSSASTGDTTPVPVT-----DTSSVSTG 3228

Query: 111  HAVASATPVAVTAPPAHLT------PAVPLSF-SEGLMKPPPKPTMPS------RPIAPA 157
            HA    TP+ VT   +  T      P   +S  S G   P P     S       P+   
Sbjct: 3229 HA----TPLPVTGLSSASTGDTTRLPVTDISSASTGQATPLPVTNTSSVSTGDTMPLPVT 3284

Query: 158  PPSTLSLPPKVPGQVTVTMESSIPQASAIPV-ATISGQQGHPSNLHHIMTTN-------- 208
             PS+ S     P  VT T  +S   A+ +PV +T S   GH + L    T++        
Sbjct: 3285 SPSSASTGHATPLPVTSTSSASTGHATPVPVTSTSSASTGHTTPLPVTDTSSASTGDTTP 3344

Query: 209  --VQMSIIRSNAPGPPLH--IGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPA 264
              V      S     PLH  I +S      +   V  +S  +T     + LP   T+  +
Sbjct: 3345 LPVTSPSSASTGHTTPLHVTIPSSASTGDTSTLPVTGASSAST--GHATPLPVTDTSSVS 3402

Query: 265  VQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTL---- 320
              H    P+ S   V+T +  P  V    SA+  Q+  +  T+  +  +  + P L    
Sbjct: 3403 TGHATPLPVTSLSSVSTGDTTPLPVTDASSASTGQATPLPVTSLSSVSTGDTTPLLVTDA 3462

Query: 321  ---SIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTG--TPV 375
               S  H     ++    A + D TTR+ +    +  T +     +   +  STG  TP+
Sbjct: 3463 SSVSTGHATPLPVTDTSSASTGD-TTRLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPL 3521

Query: 376  AAATVAPILATNTIPSATTAGSVSHTQAPTSTIVT--------------MTVPSHSS--H 419
                 + +   +  P   T  S + T   T   VT              +T+PS SS  H
Sbjct: 3522 LVTDASSVSTGHATPLPVTDTSSASTGDTTRLPVTDTSSASTGQATPLPVTIPSSSSSGH 3581

Query: 420  ATAV---TTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSD 476
             T +   +TS++    V P  +T  S            + +P++   ++    A      
Sbjct: 3582 TTPLPVTSTSSVSTGHVTPLHVTSPSSA-----STGHVTPLPVTSTSSASTGHATPLLVT 3636

Query: 477  NRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGV 536
            +  SV       LP    S+      T  P+T + S       + QA    +T+ + V  
Sbjct: 3637 DASSVSTGHATPLPVTDASSASTGDTTPLPVTDTSSAS-----TGQATPLPVTSLSSVST 3691

Query: 537  ASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATP 596
              T  L      +    HA  +    P+ +ST    P P+ +P        +     ATP
Sbjct: 3692 GDTTPLPVTDASSASTGHATPLPVTIPSSVSTGDTMPLPVTSP-------SSASTGHATP 3744

Query: 597  INTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATT-VVQTHSQSA 655
            +   GL  A  G   P P   TS+        +   P+++  SA+   TT +  T   SA
Sbjct: 3745 LPVTGLSSASTGDTTPLPVTDTSSASTRHATPL---PVTDTSSASTDDTTRLPVTDVSSA 3801

Query: 656  STNAPAQGSSPRPSILRKKPATDGAKP-----KSEIHVSMATPVTVSMETVSNQNNDQPT 710
            ST      ++P P       +T    P      S +    AT + V+  + ++  +  P 
Sbjct: 3802 STG----HATPLPVTSTSSASTGDTTPLPVTDTSSVSTGHATSLPVTSRSSASTGHATPL 3857

Query: 711  IAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGS 770
                      P T  + ++       P  + S++           +   A P  VT   S
Sbjct: 3858 ----------PVTDTSSVSTGHATPLPVTSTSSV-----------STGHATPLPVTSPSS 3896

Query: 771  LSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLAT------NTVSPSLALLANNLSMPTS 824
             S+    PVP               PV+    L+T      +  SPS A   +  ++P +
Sbjct: 3897 ASTGHATPVPVTSTSSASTGDTTPLPVTNASSLSTGHATPLHVTSPSSASRGDTSTLPVT 3956

Query: 825  DLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKST 862
            D    ++    P     + S   GD      TD   ++
Sbjct: 3957 DASSASTGHATPLPLTSLSSVSTGDTTPLPVTDTSSAS 3994



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 189/817 (23%), Positives = 291/817 (35%), Gaps = 83/817 (10%)

Query: 39   STG-LSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVV 97
            STG  +  P    +S S G   P   V D S   +  +    ++S SS+ + +    PV 
Sbjct: 2762 STGHATPLPLTSLSSVSTGDTTPLP-VTDTSSASTGQATPLPVTSLSSVSTGDTTPLPVT 2820

Query: 98   VRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPL---SFSEGLMKPPPKPTMPSRPI 154
                      ST HA +       +A   H TP       S S G     P     S  I
Sbjct: 2821 -----DTSSASTGHATSLPVTDTSSASTGHATPLPDTDTSSASTGHATLLPVTDTSSASI 2875

Query: 155  APAPP------STLSLPPKVPGQVTVTMESSIPQASAIPVA-TISGQQGHPSNLHHIMTT 207
              A        S++S     P  VT    +S   A+ +PV  T S   GH + LH     
Sbjct: 2876 GHATSLPVTDTSSISTGHATPLHVTSPSSASTGHATPLPVTDTSSASTGHANPLH----V 2931

Query: 208  NVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQH 267
                S    +A   P+   +S     A    V S S V+T    T+ LP  + +  +  H
Sbjct: 2932 TSPSSASTGHATPLPVTDTSSASTGHATPLPVTSLSSVST--GDTTPLPVTSPSSASTGH 2989

Query: 268  IIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPV--ITTTAAHATDSALSRPTLSIQHP 325
                P+      +T  A    V +T SA+   +    +T T++ +T  A   P  S+   
Sbjct: 2990 TTPLPVTDTSSASTGQATALPVTSTSSASTGDTTPLPVTDTSSASTGQATPLPVTSLSS- 3048

Query: 326  PSAAISIQRPAQSRDVTTR-ITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPIL 384
                        + D T   +T PS  + G     L T A        TP+   +++ + 
Sbjct: 3049 ----------VSTGDTTPLPVTSPSSASTGHATPLLVTDASSASTGQATPLPVTSLSSVS 3098

Query: 385  ATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAV---TTSNIPVAKVVPQQITHT 441
              +T P   T+ S + T   TS  VT T  + +   T++    TS+          +T T
Sbjct: 3099 TGDTTPLPVTSPSSASTGHATSLPVTDTSSASTGDTTSLPVTDTSSAYTGDTTSLPVTDT 3158

Query: 442  SPRIQPD-YPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLA 500
            S     D  P   +    +S   A+P  V   + +    + P      L    PS+    
Sbjct: 3159 SSSSTGDTTPLLVTETSSVSTGHATPLLVTDASSASTGHATP------LHVTSPSSASTG 3212

Query: 501  AHTYTPI--TSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHI 558
              T  P+  TSSVST    P+     +SA T         T  L    + +     A  +
Sbjct: 3213 DTTPVPVTDTSSVSTGHATPLPVTGLSSAST-------GDTTRLPVTDISSASTGQATPL 3265

Query: 559  QGIQPAPISTQGIQPAPIGTPG------IQPAPLGTQGIHS---ATPINTQGLQPAPMGT 609
                 + +ST    P P+ +P         P P+ +    S   ATP+       A  G 
Sbjct: 3266 PVTNTSSVSTGDTMPLPVTSPSSASTGHATPLPVTSTSSASTGHATPVPVTSTSSASTGH 3325

Query: 610  QQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQ-THSQSAST----NAPAQG- 663
              P P   TS+    D   +   P+++P SA+   TT +  T   SAST      P  G 
Sbjct: 3326 TTPLPVTDTSSASTGDTTPL---PVTSPSSASTGHTTPLHVTIPSSASTGDTSTLPVTGA 3382

Query: 664  SSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPT 723
            SS         P TD     S +    ATP+ V+  +  +  +  P      ++      
Sbjct: 3383 SSASTGHATPLPVTD----TSSVSTGHATPLPVTSLSSVSTGDTTPLPVTDASSASTGQA 3438

Query: 724  IPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIK 783
             P  + + S  S       T P  V     ++T  A P P VT   S S+     +P   
Sbjct: 3439 TPLPVTSLSSVSTG----DTTPLLVTDASSVSTGHATPLP-VTDTSSASTGDTTRLPVTD 3493

Query: 784  VKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLS 820
                        PV+++  ++T   +P L   A+++S
Sbjct: 3494 TSSASTGQATPLPVTSLSSVSTGDTTPLLVTDASSVS 3530



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 175/797 (21%), Positives = 278/797 (34%), Gaps = 113/797 (14%)

Query: 143  PPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVA-TISGQQGHPSNL 201
            PP  P++ S  +      T +L P   G+   T  + I  A+ +PV    S   GH + L
Sbjct: 936  PPTPPSITSTGLTSPQTETHTLSPSGSGKTFTT--ALISNATPLPVTYASSASTGHTTPL 993

Query: 202  HHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTS-------- 253
            H    ++V            P  +   H            S+   T L  TS        
Sbjct: 994  HVTDASSVSTGHATPLPVTSPSSVSTGHTTPLPVTDTSSESTGHVTPLPVTSFSSASTGD 1053

Query: 254  --QLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSAT--RAQSPVITTTAAH 309
               LP   T+  +  H+   P+ S    +T +  P  V  T SA+   A S  +T T++ 
Sbjct: 1054 STPLPVTDTSSASTGHVTPLPVTSLSSASTGDTTPLPVTDTSSASTGHATSLPVTDTSSV 1113

Query: 310  ATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIF 369
            +T      P        +   +      +  V+T  T P H           T A     
Sbjct: 1114 STGHTTPLPVTDTSSASTGHATSLPVTDTSSVSTGHTTPLHV----------TDASSAST 1163

Query: 370  STGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHAT-------- 421
               TP+   +++ +   +T P   T+ S + T   T  +VT T  + + HAT        
Sbjct: 1164 GQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDTSSASTGHATPLPVTDAS 1223

Query: 422  AVTT---SNIPVAKVVPQQITHTSPRIQPDYPA----ERSSLI-----PISGHRASPNPV 469
            +V+T   +++PV         HT+P    D  +    + +SL+      +S    +P PV
Sbjct: 1224 SVSTDHATSLPVTIPSAASTGHTTPLPVTDTSSASTGQATSLLVTDTSSVSTGDTTPLPV 1283

Query: 470  AMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPIT--SSVSTIRQYPVSAQAPNSA 527
               + +      P      L    PS+      T  P+T  SS ST    P+   +P+SA
Sbjct: 1284 TSTSSASTGHVTP------LHVTSPSSASTGHATPLPVTSLSSASTGDTMPLPVTSPSSA 1337

Query: 528  ITAQ------TGVGVASTVHLNPMQLMTVDASHARHIQGIQPAP------ISTQGIQPAP 575
             T        T     ST H  P+ +   DAS A   Q   P P      +ST    P P
Sbjct: 1338 STGDTTPLPVTDASSVSTGHTTPLHV--TDASSASTGQA-TPLPVTSLSSVSTGDTTPLP 1394

Query: 576  IGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPIS 635
            + +P        +     ATP+       A  G   P P    S+ V  D AT +  P++
Sbjct: 1395 VTSP-------SSASTGHATPLLVTDTSSASTGHATPLPVTDASS-VSTDHATSL--PVT 1444

Query: 636  NPFSAAPAATTVVQ-THSQSAST------------NAPAQGSSPRPSILRKKPATDGAKP 682
             P +A+   TT +  T + SAST            +     ++P P       +T    P
Sbjct: 1445 IPSAASTGHTTPLPVTDTSSASTGQATSLLVTDTSSVSTGDTTPLPVTSTSSASTGHVTP 1504

Query: 683  -----KSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAAS----- 732
                  S      ATP+ V+  + ++  +  P     P++     T P  +  AS     
Sbjct: 1505 LHVTSPSSASTGHATPLPVTSLSSASTGDTMPLPVTSPSSASTGDTTPLPVTDASSVSTG 1564

Query: 733  -----PPSQPAVALSTIPGAVPITPPITTIAA-APPPSVTVGGSLSSVLGPPVPEIKVKE 786
                 P + P+ A +     +P+T   +       P  VT   S S+    P+P      
Sbjct: 1565 HTTPLPVTSPSSASTGHTTPLPVTDTSSASKGDTTPLPVTSPSSASTGHTTPLPVTDTSS 1624

Query: 787  EVEPMDIMRPVSAVPPLAT------NTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQ 840
                     PV+    L+T      +  SPS A   +   +P +     ++    P    
Sbjct: 1625 ASTGDTTPLPVTNASSLSTGHATPLHVTSPSSASTGHATPLPVTSTSSASTGHATPLPVT 1684

Query: 841  HVISTEEGDMMETNSTD 857
             + S    D      TD
Sbjct: 1685 GLSSATTDDTTRLPVTD 1701



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 195/870 (22%), Positives = 307/870 (35%), Gaps = 157/870 (18%)

Query: 39   STG-LSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVV 97
            STG ++  P    +S S G   P   V D S   +  +    ++ +SS+ +      PV 
Sbjct: 1066 STGHVTPLPVTSLSSASTGDTTPLP-VTDTSSASTGHATSLPVTDTSSVSTGHTTPLPVT 1124

Query: 98   VRPYPQVQMLSTHHAVASATPVAVTAP-------PAHLTPAVPLSFSEGLMKPPPKPTMP 150
                      ST HA  ++ PV  T+        P H+T A   S S G   P P  ++ 
Sbjct: 1125 -----DTSSASTGHA--TSLPVTDTSSVSTGHTTPLHVTDAS--SASTGQATPLPVTSLS 1175

Query: 151  S------RPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHI 204
            S       P+    PS+ S     P  VT T  +S   A+ +PV   S       +  H 
Sbjct: 1176 SVSTGDTTPLPVTSPSSASTGHATPLLVTDTSSASTGHATPLPVTDASSV-----STDHA 1230

Query: 205  MTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPA 264
             +  V +    S     PL +  +       A +++ +   +     T+ LP  +T+  +
Sbjct: 1231 TSLPVTIPSAASTGHTTPLPVTDTSSASTGQATSLLVTDTSSVSTGDTTPLPVTSTSSAS 1290

Query: 265  VQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQS---PVIT----------------- 304
              H+    + S    +T +A P  V +  SA+   +   PV +                 
Sbjct: 1291 TGHVTPLHVTSPSSASTGHATPLPVTSLSSASTGDTMPLPVTSPSSASTGDTTPLPVTDA 1350

Query: 305  -------TTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALG--T 355
                   TT  H TD++ +      Q  P    S+   +        +T PS  + G  T
Sbjct: 1351 SSVSTGHTTPLHVTDASSASTG---QATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHAT 1407

Query: 356  PKQQLHTMAQKTIFSTGTPVA-AATVAPILATN---TIPSATTAGSVSHTQAPTSTIVTM 411
            P     T +  T  +T  PV  A++V+   AT+   TIPSA + G   HT   T   VT 
Sbjct: 1408 PLLVTDTSSASTGHATPLPVTDASSVSTDHATSLPVTIPSAASTG---HT---TPLPVTD 1461

Query: 412  TVPSHSSHATAVT---TSNIPVAKVVPQQITHTSP----RIQPDYPAERSSLIPISGHRA 464
            T  + +  AT++    TS++      P  +T TS      + P +    SS    +GH A
Sbjct: 1462 TSSASTGQATSLLVTDTSSVSTGDTTPLPVTSTSSASTGHVTPLHVTSPSSAS--TGH-A 1518

Query: 465  SPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPIT--SSVSTIRQYPVSAQ 522
            +P PV   + +    ++P      LP   PS+      T  P+T  SSVST    P+   
Sbjct: 1519 TPLPVTSLSSASTGDTMP------LPVTSPSSASTGDTTPLPVTDASSVSTGHTTPLPVT 1572

Query: 523  APNSAITAQT------GVGVASTVHLNPMQLMTVDASHARHIQGIQPAPI------STQG 570
            +P+SA T  T          AS     P+ + +  ++   H     P P+      ST  
Sbjct: 1573 SPSSASTGHTTPLPVTDTSSASKGDTTPLPVTSPSSASTGHTT---PLPVTDTSSASTGD 1629

Query: 571  IQPAPI----------GTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSA 620
              P P+           TP    +P      H ATP+       A  G   P P    S+
Sbjct: 1630 TTPLPVTNASSLSTGHATPLHVTSPSSASTGH-ATPLPVTSTSSASTGHATPLPVTGLSS 1688

Query: 621  VVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGA 680
                D   +    +S+  +       V    S S     P   +SP              
Sbjct: 1689 ATTDDTTRLPVTDVSSASTGQATPLPVTSLSSVSTGDTTPLPVTSP-------------- 1734

Query: 681  KPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVA 740
               S      A+P+ V+  + ++     P           P T  + ++ A     P   
Sbjct: 1735 ---SSASTGHASPLLVTDASSASTGQATPL----------PVTDTSSVSTAHATPLPVTG 1781

Query: 741  LSTIPGAVPITPPITTIAAAP-----PPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMR 795
            LS+         P+T +++A      P  VT   S S+    P+P               
Sbjct: 1782 LSSASTDDTTRLPVTDVSSASTGQAIPLPVTSPSSASTGDTTPLPVTDASSASTGDTTSL 1841

Query: 796  PVSAVPPLATNTVSPSLALLANNLSMPTSD 825
            PV+           PS A   +  S+P +D
Sbjct: 1842 PVTI----------PSSASSGHTTSLPVTD 1861



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 186/830 (22%), Positives = 296/830 (35%), Gaps = 120/830 (14%)

Query: 100  PYPQVQMLSTHHAVASATPVAVTAPPAHLT-PAVPL------SFSEGLMKPPPKPTMPS- 151
            P      +ST HA    TP+ VT+  +  T    PL      S S G   P P  ++ S 
Sbjct: 3394 PVTDTSSVSTGHA----TPLPVTSLSSVSTGDTTPLPVTDASSASTGQATPLPVTSLSSV 3449

Query: 152  -----RPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVA-TISGQQGHPSNLHHIM 205
                  P+     S++S     P  VT T  +S    + +PV  T S   G  + L    
Sbjct: 3450 STGDTTPLLVTDASSVSTGHATPLPVTDTSSASTGDTTRLPVTDTSSASTGQATPL---- 3505

Query: 206  TTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVM----SSSKVTTVLRPTSQLPNAATA 261
                 +S + +    P L   AS +  G A    +    S+S   T   P +   +A+T 
Sbjct: 3506 -PVTSLSSVSTGDTTPLLVTDASSVSTGHATPLPVTDTSSASTGDTTRLPVTDTSSASTG 3564

Query: 262  QP-----------AVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHA 310
            Q            +  H    P+ S   V+T +  P  V +  SA+      +  T+  +
Sbjct: 3565 QATPLPVTIPSSSSSGHTTPLPVTSTSSVSTGHVTPLHVTSPSSASTGHVTPLPVTSTSS 3624

Query: 311  TDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFS 370
              +  + P L +    S +     P    D ++  T  + P   T      T        
Sbjct: 3625 ASTGHATPLL-VTDASSVSTGHATPLPVTDASSASTGDTTPLPVTDTSSAST-------G 3676

Query: 371  TGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTM--TVPSHSSHATAVTT-SN 427
              TP+   +++ +   +T P   T  S + T   T   VT+  +V +  +    VT+ S+
Sbjct: 3677 QATPLPVTSLSSVSTGDTTPLPVTDASSASTGHATPLPVTIPSSVSTGDTMPLPVTSPSS 3736

Query: 428  IPVAKVVPQQITHTSPRIQPDY-PAERSSLIPISGHRASPNPVA--METRSDNRPSVPVQ 484
                   P  +T  S     D  P   +     S   A+P PV       +D+   +PV 
Sbjct: 3737 ASTGHATPLPVTGLSSASTGDTTPLPVTDTSSASTRHATPLPVTDTSSASTDDTTRLPVT 3796

Query: 485  FQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQ------TGVGVAS 538
                  T   +  P+ +      TSS ST    P+     +S  T        T    AS
Sbjct: 3797 DVSSASTGHATPLPVTS------TSSASTGDTTPLPVTDTSSVSTGHATSLPVTSRSSAS 3850

Query: 539  TVHLNPMQLM---TVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSAT 595
            T H  P+ +    +V   HA  +     + +ST    P P+ +P        +     AT
Sbjct: 3851 TGHATPLPVTDTSSVSTGHATPLPVTSTSSVSTGHATPLPVTSPS-------SASTGHAT 3903

Query: 596  PINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAAT-TVVQTHSQS 654
            P+       A  G   P P   T+A  L+ G     + +++P SA+   T T+  T + S
Sbjct: 3904 PVPVTSTSSASTGDTTPLPV--TNASSLSTGHATPLH-VTSPSSASRGDTSTLPVTDASS 3960

Query: 655  ASTNAPAQGSSPRPSILRKKPATDGAKP-----KSEIHVSMATPVTVSMETVSNQNNDQP 709
            AST      ++P P       +T    P      S      ATP+ V+  +  +  +  P
Sbjct: 3961 ASTGH----ATPLPLTSLSSVSTGDTTPLPVTDTSSASTGQATPLPVTSLSSVSTGDTTP 4016

Query: 710  TIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAA-----PPPS 764
                       P TIP+  ++    S P    S++        P+T+ ++A      P  
Sbjct: 4017 L----------PVTIPSSASSGHTTSLPVTDASSVSTGHGTPLPVTSTSSASTGDTTPLP 4066

Query: 765  VTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTS 824
            VT   S S+    P+P               PV+++  ++T   +P     A + S  +S
Sbjct: 4067 VTDTSSASTGHATPLPVTDTSSASTGHATPLPVTSLSSVSTGHATPLAVSSATSASTVSS 4126

Query: 825  DLP-----PG-ASPRKK------------PRKQQHVISTEEGDMMETNST 856
            D P     PG  +P  K            P   Q +IST     M T ST
Sbjct: 4127 DSPLKMETPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPSTAMHTRST 4176



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 172/843 (20%), Positives = 293/843 (34%), Gaps = 111/843 (13%)

Query: 64   VNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVR-----------PYPQVQMLSTHHA 112
            V D S   +  +   H++ +SSL + +    PV              P      +ST HA
Sbjct: 2099 VTDASSVSTGHATALHVTDASSLSTGDTTPLPVTSPSSASTGDTTPLPVTDTSSVSTGHA 2158

Query: 113  VASATPVAVTAPPAHLTPAVPL----SFSEGLMKPPP------KPTMPSRPIAPAPPSTL 162
             +       +A   H T ++P+    S S G   P P        T  + P+    PS+ 
Sbjct: 2159 TSLPVTDTSSASTGHAT-SLPVTDTSSASTGHATPLPVTDTSSASTGQATPLPVTSPSSA 2217

Query: 163  SLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPP 222
            S    +P  VT T  +S  QA+ +PV ++S      +    +   +   S+   +A   P
Sbjct: 2218 STGHAIPLLVTDTSSASTGQATPLPVTSLSSASTGDTTPLPVTDAS---SVSTGHATSLP 2274

Query: 223  LHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTS 282
            +   +S          V S S  +T       + +A++A  +  H    P+ S    +T 
Sbjct: 2275 VTSLSSVSTGDTTPLPVTSPSSASTGHATPLHVTDASSA--STGHATPLPVTSLSSASTG 2332

Query: 283  NAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVT 342
            +  P  V +  SA+   +  +  T A +  +  + P L +    SA+     P    D +
Sbjct: 2333 DTTPLPVTSPSSASTGHATPLHVTDASSVSTGDTTP-LPVTSSSSASSGHTTPLPVTDAS 2391

Query: 343  TRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQ 402
            +  T  +     TP     T +  T  +T  PV   + A    T  +P          + 
Sbjct: 2392 SASTGDT-----TPLPVTDTSSASTGHATHLPVTGLSSASTGDTTRLPVTNV------SS 2440

Query: 403  APTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGH 462
            A T     + V S SS +T  TT  +P          HT+P +  D  +       +S  
Sbjct: 2441 ASTGHATPLPVTSTSSASTGDTTP-LPGTDTSSVSTGHTTPLLVTDASS-------VSTG 2492

Query: 463  RASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPIT--SSVSTIRQYPVS 520
              +  PV   + +    + P      LP     +      T  P+T  SS+ST     + 
Sbjct: 2493 DTTRLPVTSPSSASTGHTTP------LPVTDTPSASTGDTTPLPVTNASSLSTRHATSLH 2546

Query: 521  AQAPNSAITAQ------TGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPI----STQG 570
              +P+SA T        T    AST H  P   + V ++ +       P P+    S   
Sbjct: 2547 VTSPSSASTGHATSLPVTDTSAASTGHATP---LPVTSTSSASTGDTTPLPVTDTYSAST 2603

Query: 571  IQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIV 630
             Q  P+       A  G       TP+       A  G   P P   TS+V       + 
Sbjct: 2604 GQATPLPVTDTSSASTG-----DTTPLPVTDTSSASTGHATPLPVTNTSSVSTGHATPL- 2657

Query: 631  ANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSM 690
               +++P SA+   TT +     S+ +   A             P TD     S +    
Sbjct: 2658 --HVTSPSSASTGHTTPLPVTDASSVSTGHA----------TSLPVTDA----SSVFTGH 2701

Query: 691  ATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPI 750
            AT + V++ + ++  +  P           P T  + ++     S P    S++      
Sbjct: 2702 ATSLPVTIPSSASSGHTTPL----------PVTDASSVSTGHATSLPVTDASSVSTGHAT 2751

Query: 751  TPPITTIAA-----APPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLAT 805
              P+T  ++     A P  +T   S+S+    P+P               PV+++  ++T
Sbjct: 2752 PLPVTDASSVSTGHATPLPLTSLSSVSTGDTTPLPVTDTSSASTGQATPLPVTSLSSVST 2811

Query: 806  NTVSP------SLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDE 859
               +P      S A   +  S+P +D    ++    P       S   G       TD  
Sbjct: 2812 GDTTPLPVTDTSSASTGHATSLPVTDTSSASTGHATPLPDTDTSSASTGHATLLPVTDTS 2871

Query: 860  KST 862
             ++
Sbjct: 2872 SAS 2874



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 185/849 (21%), Positives = 289/849 (34%), Gaps = 132/849 (15%)

Query: 50   ANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLST 109
            A+S S G   P   V D S   +  +    ++  SS  + +  + PV       V   ST
Sbjct: 1750 ASSASTGQATPLP-VTDTSSVSTAHATPLPVTGLSSASTDDTTRLPVT-----DVSSAST 1803

Query: 110  HHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVP 169
              A+    P+ VT+P          S S G   P P     S         T SLP  +P
Sbjct: 1804 GQAI----PLPVTSPS---------SASTGDTTPLPVTDASSASTG----DTTSLPVTIP 1846

Query: 170  GQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGP-------- 221
               +    +S+P   A  V+T     GH ++L   + T+          P P        
Sbjct: 1847 SSASSGHTTSLPVTDASSVST-----GHATSL---LVTDASSVSTGDTTPLPVTDTNSAS 1898

Query: 222  -----PLHI-GASHLPRG-AAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQ 274
                 PLH+  AS +  G A +  V S S  +T    T+ LP  + +  +  H    P+ 
Sbjct: 1899 TGDTTPLHVTDASSVSTGHATSLPVTSLSSAST--GDTTPLPVTSPSSASSGHTTPLPVT 1956

Query: 275  SRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQR 334
                V T +A    V    S +   +  +  T A +  +  + P L +    S +     
Sbjct: 1957 DASSVPTGHATSLPVTDASSVSTGHATPLPVTDASSVSTGHATP-LPVTDTSSVSTGQAT 2015

Query: 335  PAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATT 394
            P     +++  T  + P   T      T          TP+   +++ +   +T P   T
Sbjct: 2016 PLPVTSLSSASTGDTTPLPVTDTSSAST-------GQDTPLPVTSLSSVSTGDTTPLPVT 2068

Query: 395  AGSVSHTQAPTSTIVTMTVPSHSSHATAV---TTSNIPVAKVVPQQITHTSPRIQPD-YP 450
            + S + T   T  +VT      + HAT++     S++         +T  S     D  P
Sbjct: 2069 SPSSASTGHATPLLVTDASSVSTGHATSLLVTDASSVSTGHATALHVTDASSLSTGDTTP 2128

Query: 451  AERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPI--T 508
               +S    S    +P PV       +  SV       LP    S+      T  P+  T
Sbjct: 2129 LPVTSPSSASTGDTTPLPVT------DTSSVSTGHATSLPVTDTSSASTGHATSLPVTDT 2182

Query: 509  SSVSTIRQYPVSAQAPNSAITAQ------TGVGVASTVHLNPMQLMTVDASHARHIQGIQ 562
            SS ST    P+     +SA T Q      T    AST H  P  L+  D S A       
Sbjct: 2183 SSASTGHATPLPVTDTSSASTGQATPLPVTSPSSASTGHAIP--LLVTDTSSA------- 2233

Query: 563  PAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVV 622
                ST    P P+         L +      TP+          G     P    S+V 
Sbjct: 2234 ----STGQATPLPV-------TSLSSASTGDTTPLPVTDASSVSTGHATSLPVTSLSSVS 2282

Query: 623  LADGATIVANPISNPFSAAPA-ATTVVQTHSQSAST------------NAPAQGSSPRPS 669
              D   +   P+++P SA+   AT +  T + SAST            +A    ++P P 
Sbjct: 2283 TGDTTPL---PVTSPSSASTGHATPLHVTDASSASTGHATPLPVTSLSSASTGDTTPLPV 2339

Query: 670  ILRKKPATDGAKP-----KSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTI 724
                  +T  A P      S +     TP+ V+  + ++  +  P      ++     T 
Sbjct: 2340 TSPSSASTGHATPLHVTDASSVSTGDTTPLPVTSSSSASSGHTTPLPVTDASSASTGDTT 2399

Query: 725  PTMIAAASPPSQ------PAVALSTIPGAVPITPPITTIAA-----APPPSVTVGGSLSS 773
            P  +   S  S       P   LS+         P+T +++     A P  VT   S S+
Sbjct: 2400 PLPVTDTSSASTGHATHLPVTGLSSASTGDTTRLPVTNVSSASTGHATPLPVTSTSSAST 2459

Query: 774  VLGPPVPEIKVKE----EVEPMDI--MRPVSAVPPLATNTVSPSLALLANNLSMPTSDLP 827
                P+P             P+ +     VS          SPS A   +   +P +D P
Sbjct: 2460 GDTTPLPGTDTSSVSTGHTTPLLVTDASSVSTGDTTRLPVTSPSSASTGHTTPLPVTDTP 2519

Query: 828  PGASPRKKP 836
              ++    P
Sbjct: 2520 SASTGDTTP 2528



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 194/881 (22%), Positives = 317/881 (35%), Gaps = 128/881 (14%)

Query: 47   SQIANSGSAGLINPAATVN-DESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQ 105
            S +  +GS   +  AA V  D  G+     +R     +++     + Q     R    V 
Sbjct: 281  SSVPVTGSLMPVTSAALVTFDPEGQSPATFSRTSTQDTTAFSKNHQTQSVETTR----VS 336

Query: 106  MLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLP 165
             ++T + +   T   V + P+   P+  +S          + T PS     + PS++S  
Sbjct: 337  QINTLNTLTPVTTSTVLSSPSGFNPSGTVS----------QETFPSGETTTSSPSSVSNT 386

Query: 166  PKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHI 225
              V  +V   M +S          T     G  S +   ++T +  S   S A  P    
Sbjct: 387  FLVTSKV-FRMPTSRDSTLGNTEETSLSVSGTISAITSKVST-IWWSDTLSTALSP---- 440

Query: 226  GASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAI 285
             +S  P+ + A     S    T  RP  +    ++  P V     Q I +    TT    
Sbjct: 441  -SSLPPKISTAFHTQQSEGAETTGRPHER----SSFSPGVS----QEIFTLHETTTW--- 488

Query: 286  PPAVVATVSATRAQSPVITTTAAHATDSALSRPTL----SIQHPPSAAISIQRPAQSRDV 341
            P +  +    T +Q+ + +T+   AT      P+     +I   PS   +I  P +    
Sbjct: 489  PSSFSSKGHTTWSQTELPSTSTGAATRLVTGNPSTGTAGTIPRVPSKVSAIGEPGEPTTY 548

Query: 342  TTR-ITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILA-TNTIPSATTAGSVS 399
            ++   TLP     G   Q            TGT   A   +P  + T  I +AT+  S  
Sbjct: 549  SSHSTTLPKTTGAGAQTQWTQ--------ETGTTGEALLSSPSYSVTQMIKTATSPSSSP 600

Query: 400  HTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPI 459
                 TS  +T T PS ++H+T  +TS  P       Q  HT             S+ P+
Sbjct: 601  MLDRHTSQQIT-TAPS-TNHSTIHSTSTSPQESPAVSQRGHTQAPQTTQESQTTRSVSPM 658

Query: 460  SGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPV 519
            +  +    P +  T S + PS        +P   P+    AA T+ P  +      Q P 
Sbjct: 659  TDTKTVTTPGSSFTASGHSPS------EIVPQDAPTI--SAATTFAPAPTGDGHTTQAPT 710

Query: 520  SA--QAPNS----------AITAQTGV-----GVASTVHLNPMQLMTVDAS--------- 553
            +A   AP+S             ++TG       V ST      Q  +  AS         
Sbjct: 711  TALQAAPSSHDATLGPSGGTSLSKTGALTLANSVVSTPGGPEGQWTSASASTSPDTAAAM 770

Query: 554  -HARHIQGIQPAPISTQGIQPAPIG--TPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQ 610
             H    +  + A   TQ  +PA  G  T     A   + G    TP  ++G+  +   T+
Sbjct: 771  THTHQAESTE-ASGQTQTSEPASSGSRTTSAGTATPSSSGASGTTPSGSEGISTSGETTR 829

Query: 611  ---QPQPEGKT---SAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGS 664
                P  +  T   +  +L+  A+  A P+S   +++    T   T S++++   P   S
Sbjct: 830  FSSNPSRDSHTTQSTTELLSASASHGAIPVSTGMASSIVPGTFHPTLSEASTAGRPTGQS 889

Query: 665  SP-RPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIA-VPPTAQQPPP 722
            SP  PS   ++ A       S +  +  T  +   +T+S  +    T + VPPT    PP
Sbjct: 890  SPTSPSASPQETAA-----ISRMAQTQRTRTSRGSDTISLASQATDTFSTVPPT----PP 940

Query: 723  TIPTMIAAASP--------PSQPAVALST--IPGAVPITPPITTIAAA-----PPPSVTV 767
            +I T     SP        PS      +T  I  A P+  P+T  ++A      P  VT 
Sbjct: 941  SI-TSTGLTSPQTETHTLSPSGSGKTFTTALISNATPL--PVTYASSASTGHTTPLHVTD 997

Query: 768  GGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSP------SLALLANNLSM 821
              S+S+    P+P               PV+     +T  V+P      S A   ++  +
Sbjct: 998  ASSVSTGHATPLPVTSPSSVSTGHTTPLPVTDTSSESTGHVTPLPVTSFSSASTGDSTPL 1057

Query: 822  PTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKST 862
            P +D    ++    P     + S   GD      TD   ++
Sbjct: 1058 PVTDTSSASTGHVTPLPVTSLSSASTGDTTPLPVTDTSSAS 1098



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 115/497 (23%), Positives = 174/497 (35%), Gaps = 73/497 (14%)

Query: 38   PSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVV 97
            P TGLS A        S G   P   V D S   +  +    ++ +SS  + +  + PV 
Sbjct: 3746 PVTGLSSA--------STGDTTPLP-VTDTSSASTRHATPLPVTDTSSASTDDTTRLPVT 3796

Query: 98   VRPYPQVQMLSTHHAV---ASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPI 154
                  V   ST HA     ++T  A T     L      S S G     P  +  S   
Sbjct: 3797 -----DVSSASTGHATPLPVTSTSSASTGDTTPLPVTDTSSVSTGHATSLPVTSRSSAST 3851

Query: 155  APAPP------STLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTN 208
              A P      S++S     P  VT T   S   A+ +PV + S      ++  H     
Sbjct: 3852 GHATPLPVTDTSSVSTGHATPLPVTSTSSVSTGHATPLPVTSPSS-----ASTGHATPVP 3906

Query: 209  VQMSIIRSNAPGPPLHI-GASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQH 267
            V  +   S     PL +  AS L  G A    ++S    +    TS LP    +  +  H
Sbjct: 3907 VTSTSSASTGDTTPLPVTNASSLSTGHATPLHVTSPSSAS-RGDTSTLPVTDASSASTGH 3965

Query: 268  IIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPS 327
                P+ S   V+T +  P  V  T SA+  Q+  +  T+  +  +  + P         
Sbjct: 3966 ATPLPLTSLSSVSTGDTTPLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPL-------- 4017

Query: 328  AAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATN 387
                             +T+PS  + G       T A       GTP+   + +     +
Sbjct: 4018 ----------------PVTIPSSASSGHTTSLPVTDASSVSTGHGTPLPVTSTSSASTGD 4061

Query: 388  TIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQP 447
            T P   T  S + T   T   VT T  + + HAT      +PV  +      H +P    
Sbjct: 4062 TTPLPVTDTSSASTGHATPLPVTDTSSASTGHATP-----LPVTSLSSVSTGHATPLAVS 4116

Query: 448  DYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPI 507
               A  +S +      +S +P+ MET     PS+         T PP   P  + T   I
Sbjct: 4117 S--ATSASTV------SSDSPLKMETPGMTTPSLKTDGGRRTATSPP---PTTSQT---I 4162

Query: 508  TSSVSTIRQYPVSAQAP 524
             S++ +   +  S  AP
Sbjct: 4163 ISTIPSTAMHTRSTAAP 4179



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 53/212 (25%), Positives = 86/212 (40%), Gaps = 27/212 (12%)

Query: 241 SSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQS 300
           + S  TT    T  L    T+       +H  +++ PP   + + P +V  T+  T   S
Sbjct: 79  TKSTETTSKAQTDTLTQMMTSTLFSSPSVHNVMETAPPDEMTTSFPSSVTNTLMMT---S 135

Query: 301 PVITTTAAHATDSAL------SRPTLSIQHPPSAAISIQ--RPAQSRDVTTRITLPSHPA 352
             IT T +  TDS L      S        P ++A+SI   +  QSR  + R ++    A
Sbjct: 136 KTITMTTS--TDSTLGNTEETSTAGTESSTPVTSAVSITAGQEGQSRTTSWRTSIQDTSA 193

Query: 353 LG----------TPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGS----V 398
                       T + Q  T+  +T  +     +   V   ++  T PS  TA S    V
Sbjct: 194 SSQNHWTRSTQTTRESQTSTLTHRTTSTPSFSPSVHNVTGTVSQKTSPSGETATSSLCSV 253

Query: 399 SHTQAPTSTIVTMTVPSHSSHATAVTTSNIPV 430
           ++T   TS  +T+T  + S+      TS++PV
Sbjct: 254 TNTSMMTSEKITVTTSTGSTLGNPGETSSVPV 285



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 73/295 (24%), Positives = 109/295 (36%), Gaps = 42/295 (14%)

Query: 39   STG-LSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVV 97
            STG  +  P    +S S G   P    N  S      +   H++S SS    +    PV 
Sbjct: 3898 STGHATPVPVTSTSSASTGDTTPLPVTNASSLSTGHATPL-HVTSPSSASRGDTSTLPVT 3956

Query: 98   ---------VRPYPQVQMLSTHHAVASATPVAVTAPPAHLT-PAVPL------SFSEGLM 141
                       P P   + S   +    TP+ VT   +  T  A PL      S S G  
Sbjct: 3957 DASSASTGHATPLPLTSLSSV--STGDTTPLPVTDTSSASTGQATPLPVTSLSSVSTGDT 4014

Query: 142  KPPPKPTMPSR---------PIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVA-TI 191
             P P  T+PS          P+  A  S++S     P  VT T  +S    + +PV  T 
Sbjct: 4015 TPLPV-TIPSSASSGHTTSLPVTDA--SSVSTGHGTPLPVTSTSSASTGDTTPLPVTDTS 4071

Query: 192  SGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGA-SHLPRGAAAAAVMSSSKVTTVLR 250
            S   GH + L    T++       S     PL + + S +  G A    +SS+   + + 
Sbjct: 4072 SASTGHATPLPVTDTSSA------STGHATPLPVTSLSSVSTGHATPLAVSSATSASTVS 4125

Query: 251  PTSQLP--NAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVI 303
              S L         P+++    +   + PP TTS  I   + +T   TR+ +  I
Sbjct: 4126 SDSPLKMETPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPSTAMHTRSTAAPI 4180


>gi|239749951 PREDICTED: similar to mucin 2 [Homo sapiens]
          Length = 2639

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 112/497 (22%), Positives = 173/497 (34%), Gaps = 53/497 (10%)

Query: 278  PVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQ 337
            P+TT+  + P    T + +   +P+ TTT    T +    PT             Q P  
Sbjct: 1315 PITTTTTVTPTPTPTSTQSTTPTPITTTTTVTPTPT----PT-----------GTQTPTT 1359

Query: 338  SRDVTTRITLPSHPALGTPKQQ---LHTMAQKTIFSTGTPVAAATVAPILATNTI-PSAT 393
            +   TT    P+    GT       + T    T   T T     T  PI  T T+ P+ T
Sbjct: 1360 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTSTPITTTTTVTPTPT 1419

Query: 394  TAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAER 453
              G+ + T  P +T  T+T     +   A T + I     V    T T  +     P   
Sbjct: 1420 PTGTQTPTTTPITTTTTVTPTPTPTGTQAPTPTAITTTSTVTPTPTPTGTQTPTTTPITT 1479

Query: 454  SSLI---PISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSS 510
            ++ +   P      +P P A+ T +   P+ P       PT  P        T TP  + 
Sbjct: 1480 TTTVTPTPTPTGTQTPTPTAITTTTTVTPT-PTPTGTQTPTSTPITTTTTV-TPTPTPTG 1537

Query: 511  VSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQG 570
              T    P+S     +     TG    +T  +     +T             P P  TQ 
Sbjct: 1538 TQTPTPTPISTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-----------PTPTGTQT 1586

Query: 571  IQPAPIGTPGIQ---PAPLGTQGIHSATPINTQGL---QPAPMGTQQPQPEGKTSAVVLA 624
                 I T       P P  T+   + TPI T       P P GTQ P      + + ++
Sbjct: 1587 PTTVLITTTTTMTPTPTPTSTKST-TVTPITTTTTVTATPTPTGTQTP------TMIPIS 1639

Query: 625  DGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKS 684
               T+   P     S  P   T     ++  ++N P + S+P+ S     P T+     S
Sbjct: 1640 TTTTVTPTPTPTTGSTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLS 1699

Query: 685  EIH--VSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIP---TMIAAASPPSQPAV 739
             +   + M +    S  T     +   T++ PP+    PP  P   T   ++S P+   V
Sbjct: 1700 TLPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTV 1759

Query: 740  ALSTIPGAVPITPPITT 756
              +T     P   P++T
Sbjct: 1760 QTTTTSAWTPTPTPLST 1776



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 115/478 (24%), Positives = 162/478 (33%), Gaps = 52/478 (10%)

Query: 371  TGTPVAAATVAPILATNTI-PSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIP 429
            T T     T  PI  T T+ P+ T   + S T  P +T  T+T     +     TT+ I 
Sbjct: 1304 TTTTTENPTPTPITTTTTVTPTPTPTSTQSTTPTPITTTTTVTPTPTPTGTQTPTTTPIT 1363

Query: 430  VAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFL 489
                V    T T  +     P   ++ +       +P P   +T +    S P+      
Sbjct: 1364 TTTTVTPTPTPTGTQTPTTTPITTTTTV-----TPTPTPTGTQTPT----STPIT---TT 1411

Query: 490  PTYPPSAYPLAAH--TYTPITSSVS-TIRQYPVSAQAPN-SAITAQTGVGVASTVHLNPM 545
             T  P+  P      T TPIT++ + T    P   QAP  +AIT  + V    T    P 
Sbjct: 1412 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQAPTPTAITTTSTVTPTPT----PT 1467

Query: 546  QLMTVDASHARHIQGIQPAPISTQGIQPAPIG-----TPGIQPAPLGTQGIHSATPINTQ 600
               T   +       + P P  T    P P       T    P P GTQ   ++TPI T 
Sbjct: 1468 GTQTPTTTPITTTTTVTPTPTPTGTQTPTPTAITTTTTVTPTPTPTGTQ-TPTSTPITTT 1526

Query: 601  GL---QPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSAST 657
                  P P GTQ P P   ++        T    P   P       TT + T +    T
Sbjct: 1527 TTVTPTPTPTGTQTPTPTPIST--------TTTVTPTPTPTGTQTPTTTPITTTTTVTPT 1578

Query: 658  NAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTA 717
              P    +P   ++            +    +  TP+T +    +      PT    PT 
Sbjct: 1579 PTPTGTQTPTTVLITTTTTMTPTPTPTSTKSTTVTPITTTTTVTAT-----PT----PTG 1629

Query: 718  QQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGP 777
             Q P  IP        P+      ST P     T PI  +  + PP  +     S     
Sbjct: 1630 TQTPTMIPISTTTTVTPTPTPTTGSTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSS 1689

Query: 778  PVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMP--TSDLPPGASPR 833
            P+ E        P  I    +A P   T   +P+     + LS P  T+  PPG   R
Sbjct: 1690 PLTESTTLLSTLPPAIEMTSTAPPSTPT---APTTTSGGHTLSPPPSTTTSPPGTPTR 1744



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 122/535 (22%), Positives = 177/535 (33%), Gaps = 94/535 (17%)

Query: 91   EKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMP 150
            E   P  +     V    T  +  S TP  +T      T   P     G   P   P   
Sbjct: 1309 ENPTPTPITTTTTVTPTPTPTSTQSTTPTPITTT----TTVTPTPTPTGTQTPTTTPITT 1364

Query: 151  SRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQAS------AIPVATISGQQGHPSNLHHI 204
            +  + P P  T +  P      T T  +  P  +      + P+ T +     P+     
Sbjct: 1365 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTSTPITTTTTVTPTPTPTGTQ 1424

Query: 205  MTTNVQMSIIRSNAPGPPLHIGASHLPRGAAA---AAVMSSSKVTTVLRPTSQLPNAATA 261
              T   ++   +  P P         P G  A    A+ ++S VT    PT       T 
Sbjct: 1425 TPTTTPITTTTTVTPTPT--------PTGTQAPTPTAITTTSTVTPTPTPTGTQTPTTTP 1476

Query: 262  QPAVQHIIHQPI----QSRPP--VTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSAL 315
                  +   P     Q+  P  +TT+  + P    T + T   +P+ TTT    T +  
Sbjct: 1477 ITTTTTVTPTPTPTGTQTPTPTAITTTTTVTPTPTPTGTQTPTSTPITTTTTVTPTPTPT 1536

Query: 316  SRPT--------LSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQ---LHTMA 364
               T         +   P       Q P  +   TT    P+    GT       + T  
Sbjct: 1537 GTQTPTPTPISTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTVLITTTT 1596

Query: 365  QKTIFSTGTPVAAATVAPILATNTIPSATT-AGSVSHTQAPTSTIVTMTV---------- 413
              T   T T   + TV PI  T T+ +  T  G+ + T  P ST  T+T           
Sbjct: 1597 TMTPTPTPTSTKSTTVTPITTTTTVTATPTPTGTQTPTMIPISTTTTVTPTPTPTTGSTG 1656

Query: 414  -PSHSSHA--TAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVA 470
             P+H+S A    +TTSN P     PQ    TS  +      E ++L+       S  P A
Sbjct: 1657 PPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPL-----TESTTLL-------STLPPA 1704

Query: 471  METRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITA 530
            +E  S   PS P                    T    TS   T+   P +  +P    T 
Sbjct: 1705 IEMTSTAPPSTP--------------------TAPTTTSGGHTLSPPPSTTTSPPGTPTR 1744

Query: 531  QTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAP 585
             T  G +S    + +Q  T  A          P P+ST    P+ I T G++P P
Sbjct: 1745 GTTTGSSSAPTPSTVQTTTTSAWTP------TPTPLST----PSIIRTTGLRPYP 1789



 Score = 38.9 bits (89), Expect = 0.026
 Identities = 34/125 (27%), Positives = 44/125 (35%), Gaps = 16/125 (12%)

Query: 708  QPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTV 767
            QPT     T + P PT  T     +P   P    ST P     TP  TT    P P+ T 
Sbjct: 1299 QPTTMTTTTTENPTPTPITTTTTVTPTPTPTSTQSTTP-----TPITTTTTVTPTPTPT- 1352

Query: 768  GGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLP 827
             G+ +    P      V     P     P +  P   T TV+P+          PT    
Sbjct: 1353 -GTQTPTTTPITTTTTVTPTPTPTGTQTP-TTTPITTTTTVTPT--------PTPTGTQT 1402

Query: 828  PGASP 832
            P ++P
Sbjct: 1403 PTSTP 1407


>gi|151301154 mucin 6, gastric [Homo sapiens]
          Length = 2439

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 200/862 (23%), Positives = 313/862 (36%), Gaps = 168/862 (19%)

Query: 40   TGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVR 99
            TG    P+ +  +GS     P       SG     S+     + +SL S           
Sbjct: 1481 TGTIPPPTTLKATGSTHTAPPITPTT--SGTSQAHSSFSTNKTPTSLHSHTSSTH----- 1533

Query: 100  PYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPP 159
             +P+V   ST     + T      P AH   A          +PPP  T  S P   +P 
Sbjct: 1534 -HPEVTPTSTTTITPNPTSTRTRTPVAHTNSATS-------SRPPPPFTTHSPPTGSSPF 1585

Query: 160  STLSLPPKVPGQVTVTMESSIPQASAIP--VATISGQQGHPSNLHHIMTTNVQMSI---I 214
            S+         + T T  +     + +P  V   S     PS    I  T+ QM+    I
Sbjct: 1586 SSTGPMTATSFKTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASI 1645

Query: 215  RSNAPG---PPLHIGASHLPRGAA-----------AAAVMSSSKVTTVLRP-TSQLPNAA 259
             S   G   PP  + A+     A            A + ++++K +T L   TS   +A 
Sbjct: 1646 HSMPTGTIPPPTTLKATGSTHTAPTMTLTTSGTSQALSSLNTAKTSTSLHSHTSSTHHAE 1705

Query: 260  TAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPT 319
                +  +I   P        TS   PP  V T   ++++S   T      T ++L   T
Sbjct: 1706 ATSTSTTNITPNP--------TSTGTPPMTVTTSGTSQSRSSFSTAK----TSTSLHSHT 1753

Query: 320  LSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQK-----TIFSTGTP 374
             S  HP   + S          TT IT P+H + GT     HT +       T F+T +P
Sbjct: 1754 SSTHHPEVTSTS----------TTSIT-PNHTSTGTRTPVAHTTSATSSRLPTPFTTHSP 1802

Query: 375  VAAAT----VAPILATNTIPSATTAGSVSH-------------TQAPTSTIVTMTVPSHS 417
                T      P+ AT+   + TT  + SH             T   T +  T+ +P+H+
Sbjct: 1803 PTGTTPISSTGPVTATS-FQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPTHT 1861

Query: 418  SHATAVTTSNIPVAKVVPQQI------THTSPRIQPDYPAERSSLIPISGHRASPNPVAM 471
              AT+ +  ++P   + P         THT+P + P       S    S  + S + +  
Sbjct: 1862 QMATSASIHSMPTGTIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTS-LPY 1920

Query: 472  ETRSDNRPSV-PVQFQYFLP------TYPPSAYPLAAHTY---TPITSSVSTIRQYPVSA 521
             T S + P V P       P      T  P A+  +A +    TP T+        P S+
Sbjct: 1921 HTSSTHHPEVTPTSTTNITPKHTSTGTRTPVAHTTSASSSRLPTPFTTHSPPTGSSPFSS 1980

Query: 522  QAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAP---IGT 578
              P +A + QT     +T +  P    T   +H          P ST  + P+    I T
Sbjct: 1981 TGPMTATSFQT-----TTTYPTPSHPQTTLPTHV--------PPFSTSLVTPSTHTVIIT 2027

Query: 579  PGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPF 638
               Q A   +  IHS            P GT  P    K      A G+T          
Sbjct: 2028 THTQMAT--SASIHST-----------PTGTVPPPTTLK------ATGST---------- 2058

Query: 639  SAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSM 698
              AP  T      SQ+ S+ + A  SS   S     P    ++P S       +P+T  +
Sbjct: 2059 HTAPPMTVTTSGTSQTHSSFSTATASSSFISSSSWLPQNSSSRPPS-------SPITTQL 2111

Query: 699  ETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASP-------PSQPAVALSTIPGAVPIT 751
              +S+      T     ++  P P+ P+ +++  P        S P+V  S+   + P+ 
Sbjct: 2112 PHLSSATTPVSTTNQLSSSFSPSPSAPSTVSSYVPSSHSSPQTSSPSVGTSSSFVSAPVH 2171

Query: 752  PPITTIAAAPPPSVTVGGSLSSV----LGPPVPEIKVK-EEVEPMDIMRP--VSAVPPLA 804
               TT+++    S++   + +SV    L P  P          P  I  P  +SA+ P++
Sbjct: 2172 S--TTLSSGSHSSLSTHPTTASVSASPLFPSSPAASTTIRATLPHTISSPFTLSALLPIS 2229

Query: 805  TNTVS--PSLALLANNLSMPTS 824
            T TVS  PS  L ++ ++ P++
Sbjct: 2230 TVTVSPTPSSHLASSTIAFPST 2251



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 184/841 (21%), Positives = 281/841 (33%), Gaps = 166/841 (19%)

Query: 138  EGLMKPPPKPTMPSRPIAPAPPSTLSLPPKV-------------------------PGQV 172
            EG+  P   PT P  P  P  P+T S P +V                         P   
Sbjct: 1190 EGVCVPCMPPTTPQPPTTPQLPTTGSRPTQVWPMTGTSTTIGLLSSTGPSPSSNHTPASP 1249

Query: 173  TVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTN--VQMSIIRSNAPGPPLHIGASHL 230
            T T        S+ P A+ SG+   P+       T+     + +RS A  P +    +  
Sbjct: 1250 TQTPLLPATLTSSKPTAS-SGEPPRPTTAVTPQATSGLPPTATLRSTATKPTVTQATTRA 1308

Query: 231  PRGAAAAAVMSSSKVTTVLRPTSQLPNAATA--QPAVQHIIHQPIQSRPPVTTSNAIPPA 288
                A+ A  S+++ TT  R T  LP  AT+   P +    +Q +       T+   P  
Sbjct: 1309 TASTASPATTSTAQSTT--RTTMTLPTPATSGTSPTLPKSTNQELPGTTATQTTGPRPTP 1366

Query: 289  VVATVSAT----RAQSPVITTTAAHATDSALSRPTL--SIQHPPSAAISIQR----PAQS 338
               T   T    +   P  T T    T +  + P    +   PP+A   +       A S
Sbjct: 1367 ASTTGPTTPQPGQPTRPTATETTQTRTTTEYTTPQTPHTTHSPPTAGSPVPSTGPVTATS 1426

Query: 339  RDVTTRITLPSHPALGTP------KQQLHTMAQKTIFS-TGTPVAAATVAPILATNTIPS 391
               TT    PSHP    P         L T +  T+ + T   +A +       T TIP 
Sbjct: 1427 FHATTTYPTPSHPETTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASNHSAPTGTIPP 1486

Query: 392  ATT--AGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDY 449
             TT  A   +HT  P +   + T  +HSS +T  T +++          +HTS    P+ 
Sbjct: 1487 PTTLKATGSTHTAPPITPTTSGTSQAHSSFSTNKTPTSLH---------SHTSSTHHPE- 1536

Query: 450  PAERSSLIPISGHRASPNPVAMETR---------SDNRP-------SVPVQFQYFLPTYP 493
                  + P S    +PNP +  TR         + +RP       S P     F  T P
Sbjct: 1537 ------VTPTSTTTITPNPTSTRTRTPVAHTNSATSSRPPPPFTTHSPPTGSSPFSSTGP 1590

Query: 494  PSA--------YPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPM 545
             +A        YP  +H  T + + V       V+             +  ++++H  P 
Sbjct: 1591 MTATSFKTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASIHSMPT 1650

Query: 546  QLM----TVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHS-------- 593
              +    T+ A+ + H      AP  T            +  A   T  +HS        
Sbjct: 1651 GTIPPPTTLKATGSTH-----TAPTMTLTTSGTSQALSSLNTAKTST-SLHSHTSSTHHA 1704

Query: 594  -ATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHS 652
             AT  +T  + P P  T  P               T+  +  S   S+   A T    HS
Sbjct: 1705 EATSTSTTNITPNPTSTGTPP-------------MTVTTSGTSQSRSSFSTAKTSTSLHS 1751

Query: 653  QSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQP--- 709
             ++ST+ P   S+   SI     +T    P +    + ++ +     T S      P   
Sbjct: 1752 HTSSTHHPEVTSTSTTSITPNHTSTGTRTPVAHTTSATSSRLPTPFTTHSPPTGTTPISS 1811

Query: 710  ----------TIAVPPTAQQPPPTIPTMIAAASP------------PSQPAVALSTIPGA 747
                      T    PT   P  T+PT + + S             P+   +A S    +
Sbjct: 1812 TGPVTATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPTHTQMATSASIHS 1871

Query: 748  VP--ITPPITTIAA------APPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSA 799
            +P    PP TTI A      APP + T  G+  S       +              P   
Sbjct: 1872 MPTGTIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTSLPYHTSSTHHP--E 1929

Query: 800  VPPLATNTVSP------SLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMET 853
            V P +T  ++P      +   +A+  S  +S LP   +    P       ST  G M  T
Sbjct: 1930 VTPTSTTNITPKHTSTGTRTPVAHTTSASSSRLPTPFTTHSPPTGSSPFSST--GPMTAT 1987

Query: 854  N 854
            +
Sbjct: 1988 S 1988



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 104/486 (21%), Positives = 182/486 (37%), Gaps = 56/486 (11%)

Query: 40   TGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVR 99
            TG    P+ I  +GS     P       SG     S+     +S+SL           V 
Sbjct: 1874 TGTIPPPTTIKATGSTHTAPPMTPTT--SGTSQSPSSFSTAKTSTSLPYHTSSTHHPEVT 1931

Query: 100  PYPQVQMLSTHHAVASATPVAVTAPPA----------HLTPAVPLSFSE-GLMKPPPKPT 148
            P     +   H +  + TPVA T   +          H  P     FS  G M      T
Sbjct: 1932 PTSTTNITPKHTSTGTRTPVAHTTSASSSRLPTPFTTHSPPTGSSPFSSTGPMTATSFQT 1991

Query: 149  MPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTN 208
              + P  P+ P T +LP  VP   T    S +  ++   + T   Q    +++H   T  
Sbjct: 1992 TTTYP-TPSHPQT-TLPTHVPPFST----SLVTPSTHTVIITTHTQMATSASIHSTPTGT 2045

Query: 209  VQ----MSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPA 264
            V     +    S    PP+ +  S   +  ++ +  ++S  ++ +  +S LP  ++++P 
Sbjct: 2046 VPPPTTLKATGSTHTAPPMTVTTSGTSQTHSSFSTATAS--SSFISSSSWLPQNSSSRPP 2103

Query: 265  VQHIIHQ---------PIQSRPPVTTSNAIPPAVVATVSA---TRAQSPVITTTAAHATD 312
               I  Q         P+ +   +++S +  P+  +TVS+   +   SP  ++ +   + 
Sbjct: 2104 SSPITTQLPHLSSATTPVSTTNQLSSSFSPSPSAPSTVSSYVPSSHSSPQTSSPSVGTSS 2163

Query: 313  SALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQL--HTMAQKTIFS 370
            S +S P  S      +  S+     +  V+     PS PA  T  +    HT++     S
Sbjct: 2164 SFVSAPVHSTTLSSGSHSSLSTHPTTASVSASPLFPSSPAASTTIRATLPHTISSPFTLS 2223

Query: 371  TGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTT----- 425
               P++  TV+P  +++   S     S   T A T T    +  S +S +T++TT     
Sbjct: 2224 ALLPISTVTVSPTPSSHLASSTIAFPSTPRTTASTHTAPAFSSQSTTSRSTSLTTRVPTS 2283

Query: 426  ---------SNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSD 476
                     + IP + V      H  P + P      SSL   + H ++P    + +   
Sbjct: 2284 GFVSLTSGVTGIPTSPVTNLTTRHPGPTLSPTTRFLTSSL---TAHGSTPASAPVSSLGT 2340

Query: 477  NRPSVP 482
              P+ P
Sbjct: 2341 PTPTSP 2346


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 187/842 (22%), Positives = 286/842 (33%), Gaps = 110/842 (13%)

Query: 117  TPVAVTAPPAHLTPAVPLSFSEGLMKPP------PKPTMPSRPIAPAPPST--LSLPPKV 168
            TP AVT P    +PA    F +G   PP      PK +  + P+    P+T   +LP   
Sbjct: 1010 TPPAVTPPSPKGSPAAT-PFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPK 1068

Query: 169  PGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGAS 228
             G  T +++     A   P AT    +G P+                  AP PP     S
Sbjct: 1069 GGPATPSLKG----APTPPAATPPSPKGGPATPSP------------KGAPMPPAATPPS 1112

Query: 229  HLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPA 288
              P+G  A      +  T    P S  P    A P  +     P  + P      A PP 
Sbjct: 1113 --PKGGLATPPHKGAPTTPAATPPS--PKGGLATPPPKGAPTTPAATPPSPKGGLATPPP 1168

Query: 289  VVA-TVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITL 347
              A T  A    SP        AT S    PT     PPS    +  P+     TT    
Sbjct: 1169 KGAPTTPAATPPSP----KGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAAT 1224

Query: 348  PSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAG------SVSHT 401
            P  P  G               +  +P       P     T P+AT         +  H 
Sbjct: 1225 PPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHK 1284

Query: 402  QAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPIS- 460
             AP   +VT   P           ++ P     P   T  SP+  P  P  + +  P + 
Sbjct: 1285 GAPNPAVVTPPSPKGGP------ATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAV 1338

Query: 461  ---GHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQY 517
                 + +P   A    S   P+ P   +   PT PP+A P  +H   P  +  S  R  
Sbjct: 1339 TPPSPKGTPTLPATTPSSKGGPTTPSSKEG--PT-PPAATP--SHKGGPAMTPPSPKRGP 1393

Query: 518  PVSA----------------QAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGI 561
             + +                +AP + +T + G    S   L P  +  V    A      
Sbjct: 1394 AIPSPKGDPTSPAVIPLSPKKAPATPVTRE-GAATPSKGDLTPPAVTPVSLKKAPATSAP 1452

Query: 562  Q--PAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTS 619
            +  PA  S++G    P  TP     P   + + +++        PAPMG           
Sbjct: 1453 KGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPT------LP 1506

Query: 620  AVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSIL---RKKPA 676
            AV+ +    + A P S     AP AT + +   ++ +T AP +   P    +   +K PA
Sbjct: 1507 AVIPSSPKEVPATPSSRRDPIAPTATLLSK---KTPATLAPKEALIPPAMTVPSPKKTPA 1563

Query: 677  TDGAK--PKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPP 734
                K  P +      ++P  V+  T     + +  + +PP    P P       A +PP
Sbjct: 1564 IPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELL-IPPAVTSPSPKEAPTPPAVTPP 1622

Query: 735  SQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIK--VKEEVEPMD 792
            S      +  P   P +PP+T  +    P  T   S++  +G  VP+    +  +  P  
Sbjct: 1623 SPEKGPATPAPKGTPTSPPVTPSSLKDSP--TSPASVTCKMGATVPQASKGLPAKKGPTA 1680

Query: 793  IMRPVSAVPPLATNTV-SPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVIST------ 845
            +   + A  P +T  + +P+        S  TS  PP           +  +ST      
Sbjct: 1681 LKEVLVAPAPESTPIITAPTRKGPQTKKSSATS--PPICPDPSAKNGSKGPLSTVAPAPL 1738

Query: 846  --EEGDMMETNSTDDEKSTAKSLLVKAEKRKSPP------KEYIDEEGVRYVPVRPRPPI 897
               + D  +T    D   + K  L   E + S P      ++ + +     V   P PP+
Sbjct: 1739 LPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPV 1798

Query: 898  TL 899
            +L
Sbjct: 1799 SL 1800



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 155/741 (20%), Positives = 261/741 (35%), Gaps = 75/741 (10%)

Query: 92   KQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPS 151
            K  P     YP V  +    +    TP+ VT P   +  A   +F       PP  + P 
Sbjct: 416  KSSPNATYHYPLVAQMPV--SSVGTTPLVVTNP-CTIAAAPTTTFEVATCVSPPMSSGPI 472

Query: 152  RPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQM 211
              I P  P+ L + P  P + +  + +++    + P+      +  PS++     T   +
Sbjct: 473  SNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDL 532

Query: 212  SIIRSN---APGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAV--Q 266
              + ++   AP  P   G +          V ++ K +   + TS  P    +  A   +
Sbjct: 533  QTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAK 592

Query: 267  HIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPP 326
              + +P+    P ++  + P  V ++ S  +  S     +A     S+L  PT++     
Sbjct: 593  KSLGEPLPIGKPASSMTS-PLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLE 651

Query: 327  SAAISIQRPAQSRDVTTRITLPSHPALGT----PKQQLHTMAQKTIFSTGTPVAAATVAP 382
            SA  +   P  ++  +T  T  S    GT    PK   H + + T+          T  P
Sbjct: 652  SADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKN--HPVKEGTL----------TTLP 699

Query: 383  ILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTS 442
            ++ T +  +   A S  +T AP +T+V       S  + ++  +  P        I+HTS
Sbjct: 700  LVPTAS-ENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTS 758

Query: 443  PRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAH 502
              + P   + +      SG  A+ +     T   + PS P+       T  P     +A 
Sbjct: 759  A-LAPVASSPKECPTEDSGASATASSKGTLTYLADSPS-PLGVSVSPQTKRPPTKKGSAG 816

Query: 503  TYTPITSSVSTIRQYPVSAQ-APNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGI 561
              TPI +  S +   PV A   P ++++ Q      +T H +P       A     +  +
Sbjct: 817  PDTPIGNLSSPVS--PVEASFLPENSLSFQGSKDSPATTH-SPTPPSPKGAPTPSAVTPL 873

Query: 562  QPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQ------------PAPMGT 609
             P  ++   + P    TP +   P   +G  +  P     L             PAP G 
Sbjct: 874  SPKGVT---LPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGI 930

Query: 610  Q-QPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRP 668
               P P+G  +       A    +P   P + +P         +  +    PA   +P P
Sbjct: 931  PASPSPKGAPTPP-----AATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPA---TPSP 982

Query: 669  SILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMI 728
                  PA     PK       ATP        S +    P    PP+ +  P   P   
Sbjct: 983  KGAPTPPAATPPSPKG----GPATP--------SPKGAPTPPAVTPPSPKGSPAATPFPK 1030

Query: 729  AAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEV 788
             A++PP+    +    P A P+     T  AA  PS   G +  S+ G P P        
Sbjct: 1031 GASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSP 1090

Query: 789  E-------PMDIMRPVSAVPP 802
            +       P     P +A PP
Sbjct: 1091 KGGPATPSPKGAPMPPAATPP 1111



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 219/932 (23%), Positives = 312/932 (33%), Gaps = 140/932 (15%)

Query: 36   GAPSTGLSQAPSQIANSGSAGLIN----PAATVNDESGRDSEVSAREHMSSSSSLQSREE 91
            GAP+T  +  PS      +  L      PAAT     G  +  S +              
Sbjct: 1055 GAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKG------------A 1102

Query: 92   KQEPVVVRPYPQVQMLSTHHAVASATPVAV---------TAPP--AHLTPAV-PLSFSEG 139
               P    P P+  + +  H  A  TP A          T PP  A  TPA  P S   G
Sbjct: 1103 PMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGG 1162

Query: 140  LMKPPPK--PTMPSR-PIAP-----------APPSTLSLPPKVPGQVTVTMESSIPQASA 185
            L  PPPK  PT P+  P +P           AP +  + PP   G +        P   A
Sbjct: 1163 LATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPA 1222

Query: 186  IPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLP-------RGAAAAA 238
                +  G    PS      TT           P  P   GA   P       +G  A  
Sbjct: 1223 ATPPSPKGGLATPSP-KGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATP 1281

Query: 239  VMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRP-PVTTSNAIPPAVVATVSATR 297
                +    V+ P S     AT+ P  +     P  + P P  +    PP    T  A  
Sbjct: 1282 PHKGAPNPAVVTPPSPKGGPATSPP--KGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVT 1339

Query: 298  AQSPVITTTAAHATDSALSRPTLSIQH----PPSAAISIQR-PAQSRDVTTRITLPSHPA 352
              SP  T T    T S+   PT         PP+A  S +  PA +     R      PA
Sbjct: 1340 PPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKR-----GPA 1394

Query: 353  LGTPKQQLHTMAQKTIF---STGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIV 409
            + +PK    + A   +    +  TPV     A     +  P A T  S+    A ++   
Sbjct: 1395 IPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKG 1454

Query: 410  TMTVPSHSSHATA-VTTSNIPVAKVVPQQI-THTSPRIQPDYPAERSSLIPISGHRASPN 467
                PS     T    T   P     P+Q+ T +SP+  P  PA   +    +   +SP 
Sbjct: 1455 GPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPK 1514

Query: 468  PVAMETRSDNRPSVPVQFQYFLPTYP---------PSAYPLAAHTYTPITSSVSTIRQYP 518
             V     S   P  P        T           P A  + +   TP   +       P
Sbjct: 1515 EVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATP 1574

Query: 519  VSAQAPNS-AITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIG 577
             S +A +  A+T  T  G  S     P +L+   A  +      + AP       P+P  
Sbjct: 1575 SSKEASSPPAVTPSTYKGAPS-----PKELLIPPAVTS---PSPKEAPTPPAVTPPSPEK 1626

Query: 578  TPGIQPAPLGTQGIHSATPINTQGLQPAP------MGTQQPQPE----GKTSAVVLADGA 627
             P   PAP GT      TP + +    +P      MG   PQ       K     L +  
Sbjct: 1627 GPAT-PAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKE-V 1684

Query: 628  TIVANPISNPFSAAPAATTVVQTHSQSAST-------------NAPAQGSSPRPSILRKK 674
             +   P S P   AP      QT   SA++               P    +P P +  +K
Sbjct: 1685 LVAPAPESTPIITAPTRKGP-QTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQK 1743

Query: 675  PATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPP 734
             ++  AK K   H S   P+       S      P  A       P P   ++ AA SPP
Sbjct: 1744 DSSKTAKGKDASH-SPKGPLAPPESKAST-----PLTAAAFEKVLPKPESASVSAAPSPP 1797

Query: 735  SQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIM 794
                V+L   P  VP  PP      + P  V     L S   P  P  +  +E+ P+   
Sbjct: 1798 ----VSLPLAPSPVPTLPPKQQFLPSSPGLV-----LESPSKPLAPADE--DELLPL--- 1843

Query: 795  RPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETN 854
                 +PP   +   P  ++L N  +  ++ +P      K+P  + +  S  E D  E+ 
Sbjct: 1844 -----IPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESV 1898

Query: 855  STDDEKSTAKSLLVKAEKRKSPPKEYIDEEGV 886
               +E+ + ++   +A+   +     IDEE V
Sbjct: 1899 PELEEQDSTQATTQQAQLAAAAE---IDEEPV 1927



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 183/797 (22%), Positives = 296/797 (37%), Gaps = 121/797 (15%)

Query: 95  PVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPI 154
           P   +  PQ Q  +    ++SA  ++VTA      P +P   S    + P      + P 
Sbjct: 10  PATEQELPQPQAETAVLPMSSA--LSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPF 67

Query: 155 APAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSII 214
            P+P +  S P +VP           PQ+S+     +      P+ L +++   +  + +
Sbjct: 68  -PSPSTIASTPLEVP----------FPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAAL 116

Query: 215 RSNAP--GPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPT--SQLPNAATAQPAVQHIIH 270
              +P   P L    S     A  A    S + ++   P   +  P+ A A+      + 
Sbjct: 117 ALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLS 176

Query: 271 QPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATD--SALSRPTLSI-QHPPS 327
            PI    P T  N +P  VV     T +   +++T   H     +++     S+ Q  P+
Sbjct: 177 APIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPT 236

Query: 328 AAISIQRPAQSRDVTTRITL--PSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILA 385
             ++I  P Q +D T    L  P +P   + K  +   A  ++ +   PV  +       
Sbjct: 237 TTLAIASP-QVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTS------- 288

Query: 386 TNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSH--------ATAVTTSNIPVAKVVPQQ 437
                S  TAG  +    P S + +   P H S          T  +  + P  K +   
Sbjct: 289 -----SQKTAGPNTPPDFPIS-LGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTI--S 340

Query: 438 ITHTSPRIQPDYPAERSSLIPI-SGHRASPNPVA----METRSDNRPSVPVQFQYFLPTY 492
           + H+S      YP++RS + P+ S +   P  VA    +    D  PS          T 
Sbjct: 341 VDHSSTGAS--YPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSI-----TC 393

Query: 493 PPS-------AYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPM 545
            PS       ++ L+  T   + SS +    YP+ AQ P S+      VG    V  NP 
Sbjct: 394 SPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSS------VGTTPLVVTNPC 447

Query: 546 QLMTVDASHARHIQGIQP----APIST-QGIQPAPIGTPGIQPAPLGTQGIHSATPINTQ 600
            +     +       + P     PIS  +   PA +    + P    TQ    AT +   
Sbjct: 448 TIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQ---VATTLRI- 503

Query: 601 GLQPAPMGTQQPQPE---GKTSAVVLA-----DGATIVANPISNPFSAAPAATTVVQTHS 652
                P+    P PE      S+V++      D  T+ A+    PFS A A  T  +  +
Sbjct: 504 -----PVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPT 558

Query: 653 -----QSASTNAPA-QGSSPRPSILRKKPATDGAK------PKSEIHVSMATPVTV--SM 698
                Q+A  N+P+ Q +S  P I     AT   K      P  +   SM +P+ V  S 
Sbjct: 559 VLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSA 618

Query: 699 ETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPA-VALSTIPGAVPITPPIT-- 755
             +   +   P  A P    +     PT+ A     + PA VA +T  G    T   +  
Sbjct: 619 SVIKTDSYAGPDSAGP--LLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPF 676

Query: 756 ---TIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSL 812
              T++ AP       G+L+++  P VP       V P     P +   PLAT  ++P +
Sbjct: 677 LEGTVSLAPKNHPVKEGTLTTL--PLVPTASENCPVAPS----PQNTCAPLATLVLAPEI 730

Query: 813 ALLANNLSMPTSDLPPG 829
                + S+P +  PPG
Sbjct: 731 PKSVPSPSLPPAGTPPG 747



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 95/428 (22%), Positives = 150/428 (35%), Gaps = 58/428 (13%)

Query: 37   APSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPV 96
            AP+  L    +    +    LI PA TV       +  + +E  ++ SS    +E   P 
Sbjct: 1528 APTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSS----KEASSPP 1583

Query: 97   VVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAP 156
             V P       ST+    S  P  +  PPA  +P      S      PP  T PS    P
Sbjct: 1584 AVTP-------STYKGAPS--PKELLIPPAVTSP------SPKEAPTPPAVTPPSPEKGP 1628

Query: 157  A-------------PPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHH 203
            A              PS+L   P  P  VT  M +++PQAS      +  ++G P+ L  
Sbjct: 1629 ATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQAS----KGLPAKKG-PTALKE 1683

Query: 204  IMTTNVQMS--II-----------RSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLR 250
            ++      S  II           +S+A  PP+    S         + ++ + +  V +
Sbjct: 1684 VLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQK 1743

Query: 251  PTSQLPNAATAQPAVQHIIHQP-IQSRPPVTTS---NAIPPAVVATVSATRAQSPVITTT 306
             +S+      A  + +  +  P  ++  P+T +     +P    A+VSA  A SP ++  
Sbjct: 1744 DSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSA--APSPPVSLP 1801

Query: 307  AAHATDSALSRPTLSIQHPPSAAI-SIQRPAQSRDVTTRITL-PSHPALGTPKQQLHTMA 364
             A +    L      +   P   + S  +P    D    + L P  P  G    Q   + 
Sbjct: 1802 LAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVN 1861

Query: 365  QKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVT 424
              T  S G PV   +    +  N   S T + S            T      +  A A  
Sbjct: 1862 MPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAE 1921

Query: 425  TSNIPVAK 432
                PV+K
Sbjct: 1922 IDEEPVSK 1929


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 161/788 (20%), Positives = 264/788 (33%), Gaps = 161/788 (20%)

Query: 100  PYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPP 159
            P P + +  T  A    +P     PP   +   PL+   G   PP   T  S   A A  
Sbjct: 1100 PTPTLSLKPTPPAPVRLSPAP---PPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATT 1156

Query: 160  STLSLPPKVPGQVTVT--MESSIPQASAI-----------PVA----------------- 189
            + +  P   P ++ ++  M++ +P    +           PVA                 
Sbjct: 1157 TAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKL 1216

Query: 190  TISGQQ------GHPSNL-------------HHIMTTNVQMSIIRSNAPGP---PLHIGA 227
            T++G Q      G P  L             HH+++    +++I++ AP P   P+ +  
Sbjct: 1217 TLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLP 1276

Query: 228  SHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIP- 286
            S  P    A   +S       + PT  + N    +  V+      +   PP+  +   P 
Sbjct: 1277 SSTPSTTPAPTGLSLPLAANQVPPT-MVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPPS 1335

Query: 287  ---PAVV---ATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRD 340
               PAV+    T++  R  +P + T  A      L RP L + H PS  +S   P  +  
Sbjct: 1336 SGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAA-- 1393

Query: 341  VTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSH 400
                I+ P H     P      M         +PV++    P+ ++  I   TT  + + 
Sbjct: 1394 -PLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPA- 1451

Query: 401  TQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPIS 460
              AP +  ++  +   +S    +T+   P+A VVP       P + P   +  +S + + 
Sbjct: 1452 -SAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPA--APGPPSLAPSGASPSASALTLG 1508

Query: 461  -------------GHRASPNPVAMETRSDNRPSVPVQFQYFLPT------YP--PSAYPL 499
                         GH     P +      N    P      +P       +P  P+  P 
Sbjct: 1509 LATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPA 1568

Query: 500  AAHTYTPITSSVSTIRQYPVSAQAPNSAITAQT---------------GVGVASTVHLNP 544
             A    P +S+   +        AP +AI A +               G          P
Sbjct: 1569 QASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTP 1628

Query: 545  MQLMTVDASHARHIQGIQP--------APISTQGIQPAPIGTPGIQPAPLGTQGIHSATP 596
            + +M   ++    +    P        AP STQ + PAP+ +P   PA   T  +  A  
Sbjct: 1629 VPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALA 1688

Query: 597  INTQGLQPAP---MGTQQPQPEGKTSAVVLADGATIVANPI------------------- 634
                G  P+    +GT  PQ    T  + L   +++V  P                    
Sbjct: 1689 PTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSL 1748

Query: 635  --------SNPFSAAPAATTVVQTHSQSASTNAPAQ------GSSPRPSILRKKPATDGA 680
                    ++P   APA T  +   S SAS  APA         +P P++      T   
Sbjct: 1749 APAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLAL 1808

Query: 681  KPKSE-----------IHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIA 729
             P S            +  S A P+ V+M +    + D+P      +    PP+  T   
Sbjct: 1809 APASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTATSFG 1868

Query: 730  AASPPSQP 737
               P  QP
Sbjct: 1869 GPRPRRQP 1876



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 209/883 (23%), Positives = 298/883 (33%), Gaps = 154/883 (17%)

Query: 100  PYPQVQMLSTHHAVASATPVAVTAP----PAHLTPAVPLSFSEGLMKP-----------P 144
            P PQV   S   + + A P  + A     P  L P  P S S   + P           P
Sbjct: 1040 PVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRP 1099

Query: 145  PKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVA-------------TI 191
            P PT+  +P  PAP      PP  PG  ++    ++P     P A             T 
Sbjct: 1100 PTPTLSLKPTPPAPVRLSPAPP--PGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTT 1157

Query: 192  SGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIG--ASHLPRGAAAAA-------VMSS 242
            +     P+    I++ ++Q  +      G  + IG  AS   R  A A         +  
Sbjct: 1158 AVPAPTPAPQRLILSPDMQARL----PSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQG 1213

Query: 243  SKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPV 302
            +K+T       QL      +P  ++++H           S     A++  V+ T   +PV
Sbjct: 1214 NKLTLTGAQVRQLA-VGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPV 1272

Query: 303  I----TTTAAHATDSALSRPTLSIQHPPS-----AAISIQRPAQSRDVTTRITLPSHPAL 353
                 +T +     + LS P  + Q PP+       + I      RD  T +  P  PA 
Sbjct: 1273 SVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVP-PLAPAP 1331

Query: 354  GTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTV 413
              P             S+G P A     P L    +P+ T     +    PT T+V   +
Sbjct: 1332 RPP-------------SSGLP-AVLNPRPTLTPGRLPTPTLG--TARAPMPTPTLVRPLL 1375

Query: 414  PSHSSHATAVTTSNIPVAKVVPQQITHTSP-RIQPDYPAERSSLIPISGHRASPNPVAME 472
                S +  V+ S    A      +T +SP  +    P   SS +PI       +PV+  
Sbjct: 1376 KLVHSPSPEVSASAPGAAP-----LTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSST 1430

Query: 473  TRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVS--------TIRQYPVSAQAP 524
                   S+P+     LP   P++ PL      P+T S S        T    PV   AP
Sbjct: 1431 VSVPLSSSLPISVPTTLPA--PASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAP 1488

Query: 525  NSAITAQTGVGV-ASTVHLNPMQLMTVDASHAR-HIQGIQPAPISTQGIQP--APIGTPG 580
                 A +G    AS + L      ++ +S    H   + P      G+    AP  +P 
Sbjct: 1489 GPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPV 1548

Query: 581  IQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVA--NPISNPF 638
            + PA        SA         PAP       P    S  +    A + A    I  P 
Sbjct: 1549 LVPASALASPFPSAP-------NPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPS 1601

Query: 639  SAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSM 698
             A P A   V   S  A   AP   SS  P  +    +T G    S   V   TPV    
Sbjct: 1602 PAPPLAPLPVLAPSPGA---APVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPS 1658

Query: 699  ETVSNQNNDQPTIAVPPTAQQP----PPTIPTMIAAASPPSQ-------------PAVAL 741
             T +      P+    P + Q     P   PT+    S PSQ             P   L
Sbjct: 1659 STQTMLPAPVPSPLPSPASTQTLALAPALAPTL--GGSSPSQTLSLGTGNPQGPFPTQTL 1716

Query: 742  STIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVP 801
            S  P +  +  P  T++ AP P +    +LS    PP               + P S V 
Sbjct: 1717 SLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPP---------------LAPASPVG 1761

Query: 802  PLATNTV-----SPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNST 856
            P   +T+     S S +LLA   S+ T  L P   P   P   Q +        +   ST
Sbjct: 1762 PAPAHTLTLAPASSSASLLA-PASVQTLTLSPAPVPTLGPAAAQTL-------ALAPAST 1813

Query: 857  DDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITL 899
                S A SL+V A      P   +       +PV    P TL
Sbjct: 1814 QSPASQASSLVVSASGAAPLPVTMVSR-----LPVSKDEPDTL 1851



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 189/798 (23%), Positives = 284/798 (35%), Gaps = 108/798 (13%)

Query: 97   VVRPYPQVQ---MLSTHHAVASATPVAVTAPP-----AHLTPA-VPLSFSEGLM---KPP 144
            +++P P+ +   ++  ++  A   PV V  PP     A  TP  VP      LM    P 
Sbjct: 997  MLQPVPKQEGRTVVVVNNPRAPLGPVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPA 1056

Query: 145  PKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPS-NLHH 203
              P +P    A  PP  + LPP  P         S+PQ    P+  +SG    P+  L  
Sbjct: 1057 GPPLIP----ASRPPGPVLLPPLQPNS------GSLPQVLPSPLGVLSGTSRPPTPTLSL 1106

Query: 204  IMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQP 263
              T    + +  +  PG    +    +P G       +++  TT    T+    A T  P
Sbjct: 1107 KPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPT--P 1164

Query: 264  AVQHIIHQP-IQSRPPVTTSNAIPPAVVATVS--ATRAQSPVITTTAAHATDSAL--SRP 318
            A Q +I  P +Q+R        +P   V ++   A+ AQ PV     +      +  ++ 
Sbjct: 1165 APQRLILSPDMQAR--------LPSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKL 1216

Query: 319  TLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAA 378
            TL+       A+   RP Q   V        H  +  P       A   +     P    
Sbjct: 1217 TLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQP-------AHVALIQAVAPTPGP 1269

Query: 379  TVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQI 438
            T   +L     PS+T     S T APT     +++P  ++       +N  V K+V +Q 
Sbjct: 1270 TPVSVL-----PSSTP----STTPAPTG----LSLPLAANQVPPTMVNNTGVVKIVVRQA 1316

Query: 439  THTS-PRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAY 497
                   + P  PA R    P SG  A  NP    T +  R   P       P   P+  
Sbjct: 1317 PRDGLTPVPPLAPAPRP---PSSGLPAVLNP--RPTLTPGRLPTPTLGTARAPMPTPTLV 1371

Query: 498  -PLAAHTYTPITSSVSTIRQYPVSAQAPNSA-ITAQTGVGVASTVH---LNPMQL----- 547
             PL    ++P            VSA AP +A +T  + + V S++     +PM +     
Sbjct: 1372 RPLLKLVHSPSPE---------VSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSP 1422

Query: 548  MTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQP--APL-----GTQGIHSATPINTQ 600
            +    S    +      PIS     PAP   P   P  APL     G   + S TP    
Sbjct: 1423 LASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTP-PLA 1481

Query: 601  GLQPAPMGTQQPQPEGKT-SAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSA-STN 658
             + PA  G     P G + SA  L  G     +  S+     P       +H     ST 
Sbjct: 1482 PVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTV 1541

Query: 659  APAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQ 718
            APA      P+     P      P +    S+  P + + + ++            P A 
Sbjct: 1542 APACSPVLVPASALASPFPSAPNP-APAQASLLAPASSASQALAT-----------PLAP 1589

Query: 719  QPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPP 778
               P    +  + +PP  P   L+  PGA P+     T      PS T G SL+S    P
Sbjct: 1590 MAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVP 1649

Query: 779  VPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLA-LLANNL--SMPTSDLPPGASPRKK 835
             P   +        +  PV +  P   +T + +LA  LA  L  S P+  L  G    + 
Sbjct: 1650 APTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQG 1709

Query: 836  PRKQQHVISTEEGDMMET 853
            P   Q +  T    ++ T
Sbjct: 1710 PFPTQTLSLTPASSLVPT 1727



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 73/348 (20%), Positives = 128/348 (36%), Gaps = 56/348 (16%)

Query: 396  GSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQP---DYPAE 452
            G+ + TQ    T      P  S+H T  TT+  P      +++   +PR +P     PA 
Sbjct: 2401 GARAETQGANHT------PVISAHQTRSTTTP-PRCSPARERVPRPAPRPRPTPASAPAA 2453

Query: 453  RSSLIPISGHR----ASPNPVAMETRSDNRPSVPVQFQYFLP-------TYPPSAYPLAA 501
              +L+P+        ++PNP+ +       PS P   Q  +P       T PP+  P  A
Sbjct: 2454 IPALVPVPVSAPVPISAPNPITI-LPVHILPSPPPPSQ--IPPCSSPACTPPPACTPPPA 2510

Query: 502  HTYTPITSSVSTIRQ--------YPVSAQAPNSAITAQTGVGVASTVHLNP--MQLMTVD 551
            HT  P  + + T            P+SA   N  +  +    + +    +P  ++L +V 
Sbjct: 2511 HTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELASVA 2570

Query: 552  ASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQ 611
            +S    +  + P  +    ++  P+    +   P        + P  T      P G +Q
Sbjct: 2571 SSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTP--------SAPSLTLEAGSIPNGQEQ 2622

Query: 612  PQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNA---PAQGSSPRP 668
              P+        A+G T+   P         + +  ++    +AS      P +      
Sbjct: 2623 EAPDS-------AEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEADRTSE 2675

Query: 669  SILRKK-PATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPP 715
             +   K P +   KP+  +   +A P T S  T S +    P+ A PP
Sbjct: 2676 ELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEG---PSPARPP 2720



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 182/942 (19%), Positives = 305/942 (32%), Gaps = 148/942 (15%)

Query: 7    PQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINPAATVND 66
            P AG+  + G GGG   +    S++      P T +S+             +  A     
Sbjct: 2364 PGAGDESSCGTGGGTHRR----SKKAKAPERPGTRVSER------------LRGARAETQ 2407

Query: 67   ESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAP-- 124
             +     +SA +  S+++  +    ++      P P+    S   A+ +  PV V+AP  
Sbjct: 2408 GANHTPVISAHQTRSTTTPPRCSPARERVPRPAPRPRPTPASAPAAIPALVPVPVSAPVP 2467

Query: 125  ----------PAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPP--KVPGQV 172
                      P H+ P+           PPP    P    A  PP   + PP    P   
Sbjct: 2468 ISAPNPITILPVHILPS----------PPPPSQIPPCSSPACTPPPACTPPPAHTPPPAQ 2517

Query: 173  TVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPR 232
            T  +  S P     P   IS              TN+ + +     P   L   A   P 
Sbjct: 2518 TCLVTPSSPLLLGPPSVPISAS-----------VTNLPLGL----RPEAELCAQALASPE 2562

Query: 233  GAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVAT 292
                A+V SS   +  L P   L   A     V         S P +T      P     
Sbjct: 2563 SLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQ 2622

Query: 293  VSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAIS--IQRPAQSRDVTTRITLPSH 350
             +   A+   +T              +  ++ PPSAA    +Q P ++   +  +T    
Sbjct: 2623 EAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEAKT 2682

Query: 351  PALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVT 410
            P     K Q    A+    ST +   ++   P  A    P   T+  V      T     
Sbjct: 2683 PTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARP--PRRRTSADVEIRGQGTGR--- 2737

Query: 411  MTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIP-ISGHRASPNPV 469
               P        +      +  VV ++      R Q       S+L+P +S   ASP   
Sbjct: 2738 ---PGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQ---RGAASTLVPGVSETSASPGSP 2791

Query: 470  AMETRSDNRPSVPV------QFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQA 523
            ++ + S    S P+           LPT P   +    H    +T           S + 
Sbjct: 2792 SVRSMSGPESSPPIGGPCEAAPSSSLPTPPQQPFIARRHIELGVTGG--------GSPEN 2843

Query: 524  PNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPIS-----TQGIQPAP--- 575
             + A+ A T   V       P +    + S A   +G+  AP S     T G  P P   
Sbjct: 2844 GDGALLAITPPAVKRRRGRPPKK----NRSPADAGRGVDEAPSSTLKGKTNGADPVPGPE 2899

Query: 576  ---IGTPGIQ------PAPLGTQGIHS----ATPINTQGLQPAPMGTQQPQPEGKTSAVV 622
               +  P ++      P PLG Q +H      +P+  +     P     P P   +SA  
Sbjct: 2900 TLIVADPVLEPQLIPGPQPLGPQPVHRPNPLLSPVEKRRRGRPPKARDLPIPGTISSA-- 2957

Query: 623  LADG-ATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAK 681
              DG +     P  +P    P    +V   +  A+T      S+  P   R +P  +   
Sbjct: 2958 -GDGNSESRTQPPPHPSPLTPLPPLLVCPTATVANTVTTVTISTSPPKRKRGRPPKNPPS 3016

Query: 682  PKSEIHVSMATPVTVSMETVSNQNNDQPT-------IAVPPTAQQPPPTIPTMIAAA--- 731
            P+      +    T  +E+       QP         +      +P   +  +   A   
Sbjct: 3017 PRPSQLPVLDRDSTSVLESCGLGRRRQPQGQGESEGSSSDEDGSRPLTRLARLRLEAEGM 3076

Query: 732  -SPPSQPAVALSTI----------PGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVP 780
                S  ++ ++ I          PG + +TPP+ ++      +    GSL       VP
Sbjct: 3077 RGRKSGGSMVVAVIQDDLDLADSGPGGLELTPPVVSLTPKLRSTRLRPGSL-------VP 3129

Query: 781  EIKVKEEVEPMDIMRPVSAVPPLA-------TNTVSPSLALLANNLSMPTSDLPPGASPR 833
             ++  E++       PV   P LA        + + P  ++  +       +     +PR
Sbjct: 3130 PLET-EKLPRKRAGAPVGGSPGLAKRGRLQPPSPLGPEGSVEESEAEASGEEEEGDGTPR 3188

Query: 834  KKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKS 875
            ++P  ++ V +T +GD     S+        ++  +  K K+
Sbjct: 3189 RRPGPRRLVGTTNQGDQRILRSSAPPSLAGPAVSHRGRKAKT 3230


>gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]
          Length = 5765

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 167/737 (22%), Positives = 253/737 (34%), Gaps = 94/737 (12%)

Query: 115  SATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTV 174
            +++P    APPA  T AVP + SEGL  P    T+ +           S  P VPG  T 
Sbjct: 1637 TSSPGLTRAPPASTT-AVP-TLSEGLTSPRYTSTLGTATTGGPTTPAGSTEPTVPGVAT- 1693

Query: 175  TMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGA 234
               S++P  SA+P  T S     PS    +  T +  S  R           AS  P   
Sbjct: 1694 ---STLPTRSALPGTTGSLGTWRPSQPPTLAPTTMATSRARPTGTAST----ASKEPLTT 1746

Query: 235  AAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVT----------TSNA 284
            + A  + +S+++T    TS      T  P       Q      P             ++ 
Sbjct: 1747 SLAPTL-TSELSTSQAETSTPRTETTMSPLTNTTTSQGTTRCQPKCEWTEWFDVDFPTSG 1805

Query: 285  IPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPP---SAAISIQRPAQSRDV 341
            +    + T    RA    +          A + P +SI       + ++      ++ D 
Sbjct: 1806 VAGGDMETFENIRAAGGKMCWAPKSIECRAENYPEVSIDQVGQVLTCSLETGLTCKNEDQ 1865

Query: 342  TTRITL--PSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVS 399
            T R  +    +  +       H  +     ST TP +      IL T    +ATT  S  
Sbjct: 1866 TGRFNMCFNYNVRVLCCDDYSHCPSTPATSSTATPSSTPGTTWIL-TKPTTTATTTASTG 1924

Query: 400  HTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPI 459
             T  PTST+   T P      T  TT  +  +K  P     +SP      PA RS+    
Sbjct: 1925 STATPTSTL--RTAPPPKVLTTTATTPTVTSSKATPS----SSPGTATALPALRSTATTP 1978

Query: 460  SGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPV 519
            +    +P P +    +  R S        + T  PS+ P  AHT T +T++ +T      
Sbjct: 1979 TATSVTPIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETAHTSTVLTATATT------ 2032

Query: 520  SAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTP 579
               A  S  T  +  G A T  +                        +T G    P  +P
Sbjct: 2033 -TGATGSVATPSSTPGTAHTTKV---------------------PTTTTTGFTATPSSSP 2070

Query: 580  GIQPAPLGTQGIHSATPINTQGLQPAPM---GTQQPQPEGKTSAVVLADGATIVANPISN 636
            G    P     I + T   T+G    P    GT        T+   +A G+    +  + 
Sbjct: 2071 GTALTP--PVWISTTTTPTTRGSTVTPSSIPGTTHTATVLTTTTTTVATGSMATPSSSTQ 2128

Query: 637  PFSAAPAATTVVQTHSQSASTNAPAQ--GSSPRPSILRKKPATDGA-----KPKSEIHVS 689
                 P+ TT   T + + ST  P+   G++P P +L     T  A      P S +  +
Sbjct: 2129 TSGTPPSLTTTATTITATGSTTNPSSTPGTTPIPPVLTTTATTPAATSNTVTPSSALGTT 2188

Query: 690  MATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVP 749
               PV  +M T   +       ++PP++   P T+ T   +A+         S I G   
Sbjct: 2189 HTPPVPNTMATTHGR-------SLPPSS---PHTVRTAWTSAT---------SGILGTTH 2229

Query: 750  ITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRP-VSAVPPLATNTV 808
            IT P T  +     +       +  L  P P  +  E         P  +      T T 
Sbjct: 2230 ITEPSTVTSHTLAATTGTTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATA 2289

Query: 809  SPSLALLANNL-SMPTS 824
            +PS    +  L S PTS
Sbjct: 2290 TPSKTRTSTLLPSSPTS 2306



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 178/819 (21%), Positives = 282/819 (34%), Gaps = 139/819 (16%)

Query: 95   PVVVRPYPQVQMLSTHHAVASATPVAVTAPPA-HLTPAVPLSFSEGLMKPPPKPTM---- 149
            P V+        +++  A  S++P   TA PA   T   P + S   + P P  ++    
Sbjct: 1939 PKVLTTTATTPTVTSSKATPSSSPGTATALPALRSTATTPTATS---VTPIPSSSLGTTW 1995

Query: 150  -----PSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHI 204
                  + P A    +T S  P+     TV   ++    +   VAT S   G        
Sbjct: 1996 TRLSQTTTPTATMSTATPSSTPETAHTSTVLTATATTTGATGSVATPSSTPGTAHTTKVP 2055

Query: 205  MTTNVQMSIIRSNAPG----PPLHIGASHLP--RGAAA--AAVMSSSKVTTVLRPTSQLP 256
             TT    +   S++PG    PP+ I  +  P  RG+    +++  ++   TVL  T+   
Sbjct: 2056 TTTTTGFTATPSSSPGTALTPPVWISTTTTPTTRGSTVTPSSIPGTTHTATVLTTTTT-- 2113

Query: 257  NAATAQPAVQHIIHQPIQSRPPVTTS-------------------NAIPPAVVATVSATR 297
              AT   A      Q   + P +TT+                     IPP +  T +   
Sbjct: 2114 TVATGSMATPSSSTQTSGTPPSLTTTATTITATGSTTNPSSTPGTTPIPPVLTTTATTPA 2173

Query: 298  AQSPVITTTAAHATDSALSRP-TLSIQH----PPSAAISIQRPAQSRDV----TTRITLP 348
            A S  +T ++A  T      P T++  H    PPS+  +++    S       TT IT P
Sbjct: 2174 ATSNTVTPSSALGTTHTPPVPNTMATTHGRSLPPSSPHTVRTAWTSATSGILGTTHITEP 2233

Query: 349  SHPALGTPKQQLHTMAQKT-IFSTGTPVAAATVAPILATNTIPSATTAGS-VSHTQAPTS 406
            S     T      T    T   S+  P +  T +P     T P  TTA S  + T  P+ 
Sbjct: 2234 STVTSHTLAATTGTTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATATPSK 2293

Query: 407  TIVTMTVPSHSSHA--TAVTTSNIPVAKVVPQQITHTSPRIQPD-YPAERSSLIPISGHR 463
            T  +  +PS  + A  T V T          + + ++ P   P     +  S I  +G  
Sbjct: 2294 TRTSTLLPSSPTSAPITTVVTMGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSNIRAAGGA 2353

Query: 464  ASPNPVAMETRSDNRPSVPVQ----------------------------FQYFL------ 489
                P+ +E R+  +P VP++                            F Y +      
Sbjct: 2354 VCEQPLGLECRAQAQPGVPLRELGQVVECSLDFGLVCRNREQVGKFKMCFNYEIRVFCCN 2413

Query: 490  ----PTYP-------PSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITA--QTGVGV 536
                P+ P       PS+ P      T +T++ +T      +A   ++  T    T    
Sbjct: 2414 YGHCPSTPATSSTAMPSSTPGTTWILTELTTTATTTESTGSTATPSSTPGTTWILTEPST 2473

Query: 537  ASTVHLNPMQLMTVDASHAR----HIQGIQPAPISTQGIQPAPIGTPGIQPA-PLGTQGI 591
             +TV +      T  ++ A     H+      P  T   +  P  +PG   A P      
Sbjct: 2474 TATVTVPTGSTATASSTQATAGTPHVSTTATTPTVTSS-KATPFSSPGTATALPALRSTA 2532

Query: 592  HSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTH 651
             + T  +   +  + +GT   +    T+       AT  + P +   S     T      
Sbjct: 2533 TTPTATSFTAIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETVHTSTVLTTTATTTGA 2592

Query: 652  SQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPT- 710
            + S +T +   G++    +L        A P S    +   PV +S  T         T 
Sbjct: 2593 TGSVATPSSTPGTAHTTKVLTTTTTGFTATPSSSPGTARTLPVWISTTTTPTTRGSTVTP 2652

Query: 711  IAVPPTAQQPP--PTIPTMIAAAS-------------PPSQPAVAL-----------STI 744
             ++P T   P    T  T +A  S             PPS    A            S+ 
Sbjct: 2653 SSIPGTTHTPTVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITATGSTTNPSST 2712

Query: 745  PGAVPITPPITTIA---AAPPPSVTVGGSLSSVLGPPVP 780
            PG  PI P +TT A   AA   +VT   +L +   PPVP
Sbjct: 2713 PGTTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPVP 2751



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 138/600 (23%), Positives = 207/600 (34%), Gaps = 98/600 (16%)

Query: 231  PRGAAAAAVMSSSKVTTVL--RPTSQLPNAATAQPAVQHIIHQPIQSRPP-VTTSNAIPP 287
            P  ++ A   S+   T +L  + T+    A T   A+      P  + PP V TS A  P
Sbjct: 2978 PATSSTATPSSTPGTTWILTEQTTAATTTATTGSTAIPS--STPGTAPPPKVLTSTATTP 3035

Query: 288  AVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITL 347
               ++  AT + SP   TT    T +A      S    PS  +        +  T   T+
Sbjct: 3036 TATSS-KATSSSSPRTATTLPVLTSTATKSTATSFTPIPSFTLGTTGTLPEQTTTPMATM 3094

Query: 348  PSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPI-------LATNTIPSATTAGSVSH 400
             +     TP +  HT    T  +T T   ++   P        + T    +ATT  +   
Sbjct: 3095 STIHPSSTP-ETTHTSTVLTTKATTTRATSSMSTPSSTPGTTWILTELTTAATTTAATGP 3153

Query: 401  TQAPT------------STIVTMTVP------SHSSHATA----VTTSNIPVAKVVPQQI 438
            T  P+            ST  T+TVP      + S+ ATA    V TS      V+  + 
Sbjct: 3154 TATPSSTPGTTWILTEPSTTATVTVPTGSTATASSTRATAGTLKVLTSTATTPTVISSRA 3213

Query: 439  T-HTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAY 497
            T  +SP      PA RS+    +    +  P +    +  R S        + T  PS+ 
Sbjct: 3214 TPSSSPGTATALPALRSTATTPTATSVTAIPSSSLGTAWTRLSQTTTPTATMSTATPSST 3273

Query: 498  PLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARH 557
            P   HT T +T++ +T R       A  S  T  +  G A T  +               
Sbjct: 3274 PETVHTSTVLTTTTTTTR-------ATGSVATPSSTPGTAHTTKV--------------- 3311

Query: 558  IQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPM---GTQQPQP 614
                     +T G    P  +PG    P     I + T   T+G    P    GT     
Sbjct: 3312 ------PTTTTTGFTATPSSSPGTALTP--PVWISTTTTPTTRGSTVTPSSIPGTTHTAT 3363

Query: 615  EGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKK 674
               T+   +A G+    +  +      P+ TT   T + + ST  P+             
Sbjct: 3364 VLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITATGSTTNPS------------- 3410

Query: 675  PATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQP-PPTIPTMIAAASP 733
             +T G  P   +  + AT    +  TV+      P+ A+  T   P P T  T    + P
Sbjct: 3411 -STPGTTPIPPVLTTTATTPAATSSTVT------PSSALGTTHTPPVPNTTATTHGRSLP 3463

Query: 734  PSQP-------AVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKE 786
            PS P         A S I G   IT P T  +  P  + +     +  L  P P  +  E
Sbjct: 3464 PSSPHTVRTAWTSATSGILGTTHITEPSTVTSHTPAATTSTTQHSTPALSSPHPSSRTTE 3523



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 164/742 (22%), Positives = 260/742 (35%), Gaps = 105/742 (14%)

Query: 114  ASATPV---AVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPG 170
            A+A P      T P A    A+P S          + T P+  ++ A PS  S P  V  
Sbjct: 2522 ATALPALRSTATTPTATSFTAIPSSSLGTTWTRLSQTTTPTATMSTATPS--STPETVHT 2579

Query: 171  QVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGP----PLHIG 226
               +T  ++   A+   VAT S   G       + TT    +   S++PG     P+ I 
Sbjct: 2580 STVLTTTATTTGATG-SVATPSSTPGTAHTTKVLTTTTTGFTATPSSSPGTARTLPVWIS 2638

Query: 227  ASHLP--RGAAA--AAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTT- 281
             +  P  RG+    +++  ++   TVL  T+     AT   A      Q   + P +TT 
Sbjct: 2639 TTTTPTTRGSTVTPSSIPGTTHTPTVL--TTTTTTVATGSMATPSSSTQTSGTPPSLTTT 2696

Query: 282  ------------------SNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRP----- 318
                              +  IPP +  T +   A S  +T ++A  T      P     
Sbjct: 2697 ATTITATGSTTNPSSTPGTTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPVPNTTAT 2756

Query: 319  ----TLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKT-IFSTGT 373
                +LS   P +   +          TT IT PS     TP     T    T   S+  
Sbjct: 2757 THGRSLSPSSPHTVRTAWTSATSGTLGTTHITEPSTGTSHTPAATTGTTQHSTPALSSPH 2816

Query: 374  PVAAATVAPILATNTIPSATTAGS-VSHTQAPTSTIVTMTVPSHSSHA--TAVTTSNIPV 430
            P +  T +P     T P  T A S  + T  P+ T  +  +PS  + A  T V T     
Sbjct: 2817 PSSRTTESPPSPGTTTPGHTRATSRTTATATPSKTRTSTLLPSSPTSAPITTVVTMGCEP 2876

Query: 431  AKVVPQQITHTSPRIQPD-YPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQ----- 484
                 + + ++ P   P     +  S I  +G      P+ +E R+  +P VP++     
Sbjct: 2877 QCAWSEWLDYSYPMPGPSGGDFDTYSNIRAAGGAVCEQPLGLECRAQAQPGVPLRELGQV 2936

Query: 485  -----------------------FQYFLPTY------PPSAYPLAAHTYTPITSSVSTIR 515
                                   F Y +  +       PS  P  + T TP ++  +T  
Sbjct: 2937 VECSLDFGLVCRNREQVGKFKMCFNYEIRVFCCNYGHCPST-PATSSTATPSSTPGTTWI 2995

Query: 516  QYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAP 575
                +  A  +A T  T +  ++     P +++T  A+          +  S +     P
Sbjct: 2996 LTEQTTAATTTATTGSTAIPSSTPGTAPPPKVLTSTATTPTATSSKATSSSSPRTATTLP 3055

Query: 576  IGT--------PGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQ--PEGKTSAVVLAD 625
            + T            P P  T G     P  T     A M T  P   PE   ++ VL  
Sbjct: 3056 VLTSTATKSTATSFTPIPSFTLGTTGTLPEQTT-TPMATMSTIHPSSTPETTHTSTVLTT 3114

Query: 626  GATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSE 685
             AT      S    ++   TT + T   +A+T   A G +  PS     P T     +  
Sbjct: 3115 KATTTRATSSMSTPSSTPGTTWILTELTTAATTTAATGPTATPS---STPGTTWILTEPS 3171

Query: 686  IHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIP 745
               ++  P T S  T S+      T+ V  +      T PT+I++ + PS      + +P
Sbjct: 3172 TTATVTVP-TGSTATASSTRATAGTLKVLTST----ATTPTVISSRATPSSSPGTATALP 3226

Query: 746  G--AVPITPPITTIAAAPPPSV 765
               +   TP  T++ A P  S+
Sbjct: 3227 ALRSTATTPTATSVTAIPSSSL 3248



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 180/834 (21%), Positives = 278/834 (33%), Gaps = 129/834 (15%)

Query: 114  ASATPV---AVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPG 170
            A+A P      T P A    A+P S          + T P+  ++ A PS+    P+   
Sbjct: 3779 ATALPALRSTATTPTATSFTAIPSSSLGTTWTRLSQTTTPTATMSTATPSST---PETAH 3835

Query: 171  QVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPG----PPLHIG 226
              TV   ++    +   VAT S   G         TT    ++  S++PG    PP+ I 
Sbjct: 3836 TSTVLTTTATTTRATGSVATPSSTPGTAHTTKVPTTTTTGFTVTPSSSPGTARTPPVWIS 3895

Query: 227  ASHLPRGAAAAAVMSSSKVTTVLRP--TSQLPNAATAQPAVQHIIHQPIQSRPPVTTS-- 282
             +  P  + +    SS   TT      T+     AT   A      Q   + P + T+  
Sbjct: 3896 TTTTPTTSGSTVTPSSVPGTTHTPTVLTTTTTTVATGSMATPSSSTQTSGTPPSLITTAT 3955

Query: 283  -----------------NAIPPAVVATVSATRAQSPVITTTAAHATDSALSRP------- 318
                               IPP +  T +   A S  +T ++A  T      P       
Sbjct: 3956 TITATGSTTNPSSTPGTTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPVPNTTATTH 4015

Query: 319  --TLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKT-IFSTGTPV 375
              +LS   P +   +          TT IT PS     TP     T    T   S+  P 
Sbjct: 4016 GRSLSPSSPHTVRTAWTSATSGTLGTTHITEPSTGTSHTPAATTGTTQHSTPALSSPHPS 4075

Query: 376  AAATVAPILATNTIPSATTAGS-VSHTQAPTSTIVTMTVPSHSSHA--TAVTTSNIPVAK 432
            +  T +P     T P  TTA S  + T  P+ T  +  +PS  + A  T V T+      
Sbjct: 4076 SRTTESPPSPGTTTPGHTTATSRTTATATPSKTRTSTLLPSSPTSAPITTVVTTGCEPQC 4135

Query: 433  VVPQQITHTSPRIQPD-YPAERSSLIPISGHRASPNPVAMETRSDNRPSVPV-------- 483
               + + ++ P   P     +  S I  +G      P+ +E R+  +P VP+        
Sbjct: 4136 AWSEWLDYSYPMPGPSGGDFDTYSNIRAAGGAVCEQPLGLECRAQAQPGVPLGELGQVVE 4195

Query: 484  ------------------------QFQYFLPTYP--PSAYPLAAHTYTPITSSVSTIRQY 517
                                    + + F   Y   PS  P  + T  P ++  +T    
Sbjct: 4196 CSLDFGLVCRNREQVGKFKMCFNYEIRVFCCNYGHCPST-PATSSTAMPSSTPGTTWILT 4254

Query: 518  PVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIG 577
             ++  A  +A T  T    ++     P +++T  A+          +  S +     P+ 
Sbjct: 4255 ELTTTATTTASTGSTATPSSTPGTAPPPKVLTSPATTPTATSSKATSSSSPRTATTLPVL 4314

Query: 578  T--------PGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQ--PEGKTSAVVLADGA 627
            T          + P P  T G     P  T     A M T  P   PE   ++ VL   A
Sbjct: 4315 TSTATKSTATSVTPIPSSTLGTTGTLPEQTT-TPVATMSTIHPSSTPETTHTSTVLTTKA 4373

Query: 628  TIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPS-------ILRKKPAT--- 677
            T      S    ++   TT + T   +A+T   A G +  PS       IL +   T   
Sbjct: 4374 TTTRATSSTSTPSSTPGTTWILTELTTAATTTAATGPTATPSSTPGTTWILTELTTTATT 4433

Query: 678  -----DGAKPKSE-------IHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIP 725
                   A P S           S    VTV   + +  ++ Q T   P  +     T P
Sbjct: 4434 TASTGSTATPSSTPGTTWILTEPSTTATVTVPTGSTATASSTQATAGTPHVS--TTATTP 4491

Query: 726  TMIAAASPPSQPAVALSTIPG--AVPITPPITTIAAAPPPSV-TVGGSLSSVLGPPVPEI 782
            T+ ++ + PS      + +P   +   TP  T+  A P  S+ T    LS    P     
Sbjct: 4492 TVTSSKATPSSSPGTATALPALRSTATTPTATSFTAIPSSSLGTTWTRLSQTTTP----- 4546

Query: 783  KVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNL-SMPTSDLPPGASPRKK 835
                    M    P S    + T+TV  + A       S+ T    PG +   K
Sbjct: 4547 -----TATMSTATPSSTPETVHTSTVLTATATTTGATGSVATPSSTPGTAHTTK 4595



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 115/511 (22%), Positives = 179/511 (35%), Gaps = 59/511 (11%)

Query: 277  PPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPA 336
            P V TS A  P   ++  AT + SP   TT    T +A      S+   PS+ +      
Sbjct: 4282 PKVLTSPATTPTATSS-KATSSSSPRTATTLPVLTSTATKSTATSVTPIPSSTLGTTGTL 4340

Query: 337  QSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPI-------LATNTI 389
              +  T   T+ +     TP +  HT    T  +T T   ++T  P        + T   
Sbjct: 4341 PEQTTTPVATMSTIHPSSTP-ETTHTSTVLTTKATTTRATSSTSTPSSTPGTTWILTELT 4399

Query: 390  PSATTAGSVSHTQAPTST---------IVTMTVPSHSSHATAVTTSNIPVAKVVPQQITH 440
             +ATT  +   T  P+ST         + T    + S+ +TA  +S      ++ +  T 
Sbjct: 4400 TAATTTAATGPTATPSSTPGTTWILTELTTTATTTASTGSTATPSSTPGTTWILTEPSTT 4459

Query: 441  TSPRIQPDYPAERSSLIPISG--HRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYP 498
             +  +     A  SS    +G  H ++       T S   PS        LP    +A  
Sbjct: 4460 ATVTVPTGSTATASSTQATAGTPHVSTTATTPTVTSSKATPSSSPGTATALPALRSTATT 4519

Query: 499  LAAHTYTPI-TSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARH 557
              A ++T I +SS+ T          P + ++  T      TVH + +   T   + A  
Sbjct: 4520 PTATSFTAIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETVHTSTVLTATATTTGA-- 4577

Query: 558  IQGIQPAPIS--------------TQGIQPAPIGTPGIQPAP---LGTQGIHSATPINTQ 600
              G    P S              T G    P  +PG    P   + T    + T   T 
Sbjct: 4578 -TGSVATPSSTPGTAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTTTPTTS 4636

Query: 601  GLQPAPM---GTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSAST 657
            G    P    GT        T+   +A G+    +  +      P+ TT   T + + ST
Sbjct: 4637 GSTVTPSSIPGTTHTARVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITATGST 4696

Query: 658  NAPAQ--GSSPRPSILRK---KPATDGAKPKSEIHVSMAT--PVTVSMETVSNQNNDQP- 709
              P+   G++P   +L      PA   +K  S      AT  PV  S  T S   +  P 
Sbjct: 4697 TNPSSTPGTTPITPVLTSTATTPAATSSKATSSSSPRTATTLPVLTSTATKSTATSFTPI 4756

Query: 710  -------TIAVPPTAQQPPPTIPTMIAAASP 733
                   T  VP     P  T+ T+  +++P
Sbjct: 4757 PSSTLWTTWTVPAQTTTPMSTMSTIHTSSTP 4787



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 174/782 (22%), Positives = 275/782 (35%), Gaps = 81/782 (10%)

Query: 108  STHHAVASATPV---AVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSL 164
            S+    A+A P      T P A    A+P S          + T P+  ++ A PS  S 
Sbjct: 3216 SSSPGTATALPALRSTATTPTATSVTAIPSSSLGTAWTRLSQTTTPTATMSTATPS--ST 3273

Query: 165  PPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPG---- 220
            P  V     +T  ++  +A+   VAT S   G         TT    +   S++PG    
Sbjct: 3274 PETVHTSTVLTTTTTTTRATG-SVATPSSTPGTAHTTKVPTTTTTGFTATPSSSPGTALT 3332

Query: 221  PPLHIGASHLP--RGAAA--AAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSR 276
            PP+ I  +  P  RG+    +++  ++   TVL  T+     AT   A      Q   + 
Sbjct: 3333 PPVWISTTTTPTTRGSTVTPSSIPGTTHTATVLTTTTT--TVATGSMATPSSSTQTSGTP 3390

Query: 277  PPVTTS-------------------NAIPPAVVATVSATRAQSPVITTTAAHATDSALSR 317
            P +TT+                     IPP +  T +   A S  +T ++A  T      
Sbjct: 3391 PSLTTTATTITATGSTTNPSSTPGTTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPV 3450

Query: 318  P-TLSIQH----PPSAAISIQRPAQSRDV----TTRITLPSHPALGTPKQQLHTMAQKT- 367
            P T +  H    PPS+  +++    S       TT IT PS     TP     T    T 
Sbjct: 3451 PNTTATTHGRSLPPSSPHTVRTAWTSATSGILGTTHITEPSTVTSHTPAATTSTTQHSTP 3510

Query: 368  IFSTGTPVAAATVAPILATNTIPSATTAGS-VSHTQAPTSTIVTMTVPSHSSHA--TAVT 424
              S+  P +  T +P     T P  T   S  + T  P+ T  +  +PS  + A  T V 
Sbjct: 3511 ALSSPHPSSRTTESPPSPGTTTPGHTRGTSRTTATATPSKTRTSTLLPSSPTSAPITTVV 3570

Query: 425  TSNIPVAKVVPQQITHTSPRIQPDY-PAERSSLIPISGHRASPNPVAMETRSDNRPSVPV 483
            T+         + + ++ P   P     +  S I  +G      P+ +E R+  +P VP+
Sbjct: 3571 TTGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSNIRAAGGAVCEQPLGLECRAQAQPGVPL 3630

Query: 484  QFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSA------QAPNSAITAQTGVGVA 537
            + +          + L       +         Y +          P++  T+ T    +
Sbjct: 3631 R-ELGQVVECSLDFGLVCRNREQV-GKFKMCFNYEIRVFCCNYGHCPSTPATSSTATPSS 3688

Query: 538  STVHLNPMQLMTVDASHARHIQGIQPAPISTQGI-----QPAPIGTPGIQPAPLGTQGIH 592
            +      +  +T  A+      G    P ST G      +P+   T  +   P G+    
Sbjct: 3689 TPGTTWILTKLTTTATTTEST-GSTATPSSTPGTTWILTEPSTTATVTV---PTGS---- 3740

Query: 593  SATPINTQGLQPAP-MGTQQPQPEGKTS-AVVLADGATIVANPISNPFSAAPAATTVVQT 650
            +AT  +TQ     P + T    P   +S A   +   T  A P     +  P AT+    
Sbjct: 3741 TATASSTQATAGTPHVSTTATTPTVTSSKATPFSSPGTATALPALRSTATTPTATSFTAI 3800

Query: 651  HSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPT 710
             S S  T       +  P+      AT  + P++  H S  T +T +  T     +    
Sbjct: 3801 PSSSLGTTWTRLSQTTTPTATMST-ATPSSTPETA-HTS--TVLTTTATTTRATGSVATP 3856

Query: 711  IAVPPTAQQPP-PTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGG 769
             + P TA     PT  T     +P S P  A +        T P T+ +   P SV    
Sbjct: 3857 SSTPGTAHTTKVPTTTTTGFTVTPSSSPGTARTPPVWISTTTTPTTSGSTVTPSSVPGTT 3916

Query: 770  SLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPP--LATNTVSPSLALLANNLSMP-TSDL 826
               +VL      +       P    +  S  PP  + T T   +     N  S P T+ +
Sbjct: 3917 HTPTVLTTTTTTVATGSMATPSSSTQ-TSGTPPSLITTATTITATGSTTNPSSTPGTTPI 3975

Query: 827  PP 828
            PP
Sbjct: 3976 PP 3977



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 110/458 (24%), Positives = 175/458 (38%), Gaps = 72/458 (15%)

Query: 243  SKVTTVLRPTSQLPNAAT--AQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQS 300
            +++TT    T    + AT  + P    I+     + P  T +  +P    AT S+T+A +
Sbjct: 2440 TELTTTATTTESTGSTATPSSTPGTTWIL-----TEPSTTATVTVPTGSTATASSTQATA 2494

Query: 301  --PVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQ 358
              P ++TTA   T ++      S     +A  +++  A +   T+   +PS  +LGT   
Sbjct: 2495 GTPHVSTTATTPTVTSSKATPFSSPGTATALPALRSTATTPTATSFTAIPS-SSLGTTWT 2553

Query: 359  QLH-------TMAQKTIFSTGTPVAAATVAPILATNT------IPSATTAGSVSHTQAPT 405
            +L        TM+  T  ST   V  +TV    AT T         ++T G+   T+  T
Sbjct: 2554 RLSQTTTPTATMSTATPSSTPETVHTSTVLTTTATTTGATGSVATPSSTPGTAHTTKVLT 2613

Query: 406  STIVTMTVPSHSSHATA-------------------VTTSNIPVAKVVPQQITHTSPRIQ 446
            +T    T    SS  TA                   VT S+IP     P  +T T+  + 
Sbjct: 2614 TTTTGFTATPSSSPGTARTLPVWISTTTTPTTRGSTVTPSSIPGTTHTPTVLTTTTTTV- 2672

Query: 447  PDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTP 506
                A  S   P S  + S  P ++ T +    +          T  PS+ P      TP
Sbjct: 2673 ----ATGSMATPSSSTQTSGTPPSLTTTATTITATG-------STTNPSSTP----GTTP 2717

Query: 507  ITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPI 566
            I   ++T    P    A +S +T  + +G   T H  P+   T   +H R +    P  +
Sbjct: 2718 IPPVLTTTATTPA---ATSSTVTPSSALG---TTHTPPVP-NTTATTHGRSLSPSSPHTV 2770

Query: 567  ST--QGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLA 624
             T         +GT  I     GT    +AT   TQ   PA      P P  +T+    +
Sbjct: 2771 RTAWTSATSGTLGTTHITEPSTGTSHTPAATTGTTQHSTPA---LSSPHPSSRTTESPPS 2827

Query: 625  DGATIVANPISNPFSAAPAATTVVQTHS--QSASTNAP 660
             G T   +  +   + A A  +  +T +   S+ T+AP
Sbjct: 2828 PGTTTPGHTRATSRTTATATPSKTRTSTLLPSSPTSAP 2865



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 175/758 (23%), Positives = 259/758 (34%), Gaps = 122/758 (16%)

Query: 108  STHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPK--------PTMPSRPIAPAPP 159
            +T  A  S    + T   AH T  VP + + G    P          P   S    P   
Sbjct: 3288 TTTRATGSVATPSSTPGTAHTTK-VPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTR 3346

Query: 160  STLSLPPKVPGQ-----VTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSII 214
             +   P  +PG      V  T  +++   S    ++ +   G P +L    TT       
Sbjct: 3347 GSTVTPSSIPGTTHTATVLTTTTTTVATGSMATPSSSTQTSGTPPSL----TTTATTITA 3402

Query: 215  RSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQ 274
              +   P    G + +P      A   ++  +TV  P+S L    T           P+ 
Sbjct: 3403 TGSTTNPSSTPGTTPIPPVLTTTATTPAATSSTVT-PSSALGTTHTP----------PVP 3451

Query: 275  SRPPVTTSNAIPPAVVATVSA--TRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISI 332
            +    T   ++PP+   TV    T A S ++ TT  H T+     P+    H P+A  S 
Sbjct: 3452 NTTATTHGRSLPPSSPHTVRTAWTSATSGILGTT--HITE-----PSTVTSHTPAATTST 3504

Query: 333  QR---PAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTP--VAAATVAPILATN 387
             +   PA S    +  T  S P+ GT     HT       +T TP     +T+ P   T+
Sbjct: 3505 TQHSTPALSSPHPSSRTTESPPSPGTTTPG-HTRGTSRTTATATPSKTRTSTLLPSSPTS 3563

Query: 388  TIPSATTAGSVSHTQAPTSTIVTMTVPSHS-SHATAVTTSNIPVA--KVVPQQI-THTSP 443
              P  T   +    Q   S  +  + P    S     T SNI  A   V  Q +      
Sbjct: 3564 A-PITTVVTTGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSNIRAAGGAVCEQPLGLECRA 3622

Query: 444  RIQPDYPAERSSLIP--------ISGHRASPNPVAMETRSDNR---------PSVPVQFQ 486
            + QP  P      +         +  +R       M    + R         PS P    
Sbjct: 3623 QAQPGVPLRELGQVVECSLDFGLVCRNREQVGKFKMCFNYEIRVFCCNYGHCPSTPATSS 3682

Query: 487  YFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQ--TGVGVASTVHLNP 544
                T  PS+ P      T +T++ +T      +A   ++  T    T     +TV +  
Sbjct: 3683 ----TATPSSTPGTTWILTKLTTTATTTESTGSTATPSSTPGTTWILTEPSTTATVTVPT 3738

Query: 545  MQLMTVDASHAR----HIQGIQPAPISTQGIQPAPIGTPGIQ---PAPLGTQGIHSATPI 597
                T  ++ A     H+      P  T   +  P  +PG     PA   T    +AT  
Sbjct: 3739 GSTATASSTQATAGTPHVSTTATTPTVTSS-KATPFSSPGTATALPALRSTATTPTATSF 3797

Query: 598  N--------------TQGLQP-APMGTQQPQ--PEGKTSAVVLADGATI------VANPI 634
                           +Q   P A M T  P   PE   ++ VL   AT       VA P 
Sbjct: 3798 TAIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETAHTSTVLTTTATTTRATGSVATPS 3857

Query: 635  SNPFSAAPAATTVVQTHSQSASTNAPAQ--GSSPRPSI---LRKKPATDGAK-PKSEIHV 688
            S P     A TT V T + +  T  P+   G++  P +       P T G+    S +  
Sbjct: 3858 STP---GTAHTTKVPTTTTTGFTVTPSSSPGTARTPPVWISTTTTPTTSGSTVTPSSVPG 3914

Query: 689  SMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPP---TIPTMIAAASPPSQPAVALSTIP 745
            +  TP  ++  T +       T +        PP   T  T I A    + P    S+ P
Sbjct: 3915 TTHTPTVLTTTTTTVATGSMATPSSSTQTSGTPPSLITTATTITATGSTTNP----SSTP 3970

Query: 746  GAVPITPPITTIA---AAPPPSVTVGGSLSSVLGPPVP 780
            G  PI P +TT A   AA   +VT   +L +   PPVP
Sbjct: 3971 GTTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPVP 4008



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 167/715 (23%), Positives = 240/715 (33%), Gaps = 91/715 (12%)

Query: 115  SATPVAVTAPPAHLTPAVPLSF-SEGLMKPPPKP--------TMPSRPIAPAPPS---TL 162
            S TP A T    H TPA+     S    + PP P        T  SR  A A PS   T 
Sbjct: 4052 SHTPAATTGTTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATATPSKTRTS 4111

Query: 163  SLPPKVPGQV---TVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMS--IIRSN 217
            +L P  P      TV      PQ +       S     PS       +N++ +   +   
Sbjct: 4112 TLLPSSPTSAPITTVVTTGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSNIRAAGGAVCEQ 4171

Query: 218  APGPPLHIGASH-LPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHII-----HQ 271
              G      A   +P G     V  S     V R   Q+            +      H 
Sbjct: 4172 PLGLECRAQAQPGVPLGELGQVVECSLDFGLVCRNREQVGKFKMCFNYEIRVFCCNYGHC 4231

Query: 272  PIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAIS 331
            P     P T+S A+P +   T       +   TTTA+  + +A    T     PP    S
Sbjct: 4232 P---STPATSSTAMPSSTPGTTWILTELTTTATTTASTGS-TATPSSTPGTAPPPKVLTS 4287

Query: 332  IQRPAQSRDVTT-RITLPSHPALGTPKQQLHTMAQK------------TIFSTGTPVAAA 378
               PA +   T+ + T  S P   T    L + A K            T+ +TGT +   
Sbjct: 4288 ---PATTPTATSSKATSSSSPRTATTLPVLTSTATKSTATSVTPIPSSTLGTTGT-LPEQ 4343

Query: 379  TVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQI 438
            T  P+   +TI  ++T  +       TST++T    +  + ++  T S+ P    +  ++
Sbjct: 4344 TTTPVATMSTIHPSSTPETTH-----TSTVLTTKATTTRATSSTSTPSSTPGTTWILTEL 4398

Query: 439  THTSPRIQPDYPAERSSLIP----ISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPP 494
            T  +       P    S  P    I     +       T S   PS      + L     
Sbjct: 4399 TTAATTTAATGPTATPSSTPGTTWILTELTTTATTTASTGSTATPSSTPGTTWIL----- 4453

Query: 495  SAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASH 554
               P    T T  T S +T      +A  P+ + TA T   V S+         T  A  
Sbjct: 4454 -TEPSTTATVTVPTGSTATASSTQATAGTPHVSTTATTPT-VTSSKATPSSSPGTATALP 4511

Query: 555  ARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQP 614
            A       P   S   I  + +GT         T+   + TP  T          +    
Sbjct: 4512 ALRSTATTPTATSFTAIPSSSLGT-------TWTRLSQTTTPTATMSTATPSSTPETVHT 4564

Query: 615  EGKTSAVVLADGAT-IVANPISNPFSA----APAATTVVQTHSQSASTN---APAQGSSP 666
                +A     GAT  VA P S P +A     P  TT   T + S+S      P    S 
Sbjct: 4565 STVLTATATTTGATGSVATPSSTPGTAHTTKVPTTTTTGFTATPSSSPGTALTPPVWIST 4624

Query: 667  RPSILRKKPATDGA--KPKS------EIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQ 718
              +     P T G+   P S         V   T  TV+  +++  ++   T   PP+  
Sbjct: 4625 TTTPTTTTPTTSGSTVTPSSIPGTTHTARVLTTTTTTVATGSMATPSSSTQTSGTPPSL- 4683

Query: 719  QPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSS 773
                T  T I A    + P    S+ PG  PITP +T+ A  P  + +   S SS
Sbjct: 4684 ---TTTATTITATGSTTNP----SSTPGTTPITPVLTSTATTPAATSSKATSSSS 4731



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 102/421 (24%), Positives = 156/421 (37%), Gaps = 54/421 (12%)

Query: 273  IQSRPPVTTSNAIPPAVVATVSAT--RAQSPVITTTAAHATDSALSRPTLSIQHPPSAAI 330
            I ++P  T +        AT ++T   A  P + TT A       S+ T S     + A+
Sbjct: 1909 ILTKPTTTATTTASTGSTATPTSTLRTAPPPKVLTTTATTPTVTSSKATPSSSPGTATAL 1968

Query: 331  SIQRPAQSRDVTTRITLPSHPALGTPKQQLH-----TMAQKTIFSTGTPVAAATVAPILA 385
               R   +    T +T     +LGT   +L      T    T   + TP  A T   + A
Sbjct: 1969 PALRSTATTPTATSVTPIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETAHTSTVLTA 2028

Query: 386  TNTIPSAT--------TAGSVSHTQAPTSTIVTMTVPSHSSHATAVT------TSNIPVA 431
            T T   AT        T G+   T+ PT+T    T    SS  TA+T      T+  P  
Sbjct: 2029 TATTTGATGSVATPSSTPGTAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTT 2088

Query: 432  K---VVPQQI---THTSPRIQPDYP--AERSSLIPISGHRASPNPVAMETRSDNRPSVPV 483
            +   V P  I   THT+  +       A  S   P S  + S  P ++ T +    +   
Sbjct: 2089 RGSTVTPSSIPGTTHTATVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITATG- 2147

Query: 484  QFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLN 543
                   T  PS+ P      TPI   ++T    P    A ++ +T  + +G   T H  
Sbjct: 2148 ------STTNPSSTP----GTTPIPPVLTTTATTPA---ATSNTVTPSSALG---TTHTP 2191

Query: 544  PMQLMTVDASHARHIQGIQPAPISTQGIQPAP--IGTPGIQPAPLGTQGIHSATPINTQG 601
            P+   T+  +H R +    P  + T         +GT  I      T    +AT   TQ 
Sbjct: 2192 PVP-NTMATTHGRSLPPSSPHTVRTAWTSATSGILGTTHITEPSTVTSHTLAATTGTTQH 2250

Query: 602  LQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHS--QSASTNA 659
              PA      P P  +T+    + G T   +  +   + A A  +  +T +   S+ T+A
Sbjct: 2251 STPA---LSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATATPSKTRTSTLLPSSPTSA 2307

Query: 660  P 660
            P
Sbjct: 2308 P 2308



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 115/521 (22%), Positives = 187/521 (35%), Gaps = 95/521 (18%)

Query: 243  SKVTTVLRPTSQLPNAAT--AQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQS 300
            +K+TT    T    + AT  + P    I+     + P  T +  +P    AT S+T+A +
Sbjct: 3697 TKLTTTATTTESTGSTATPSSTPGTTWIL-----TEPSTTATVTVPTGSTATASSTQATA 3751

Query: 301  --PVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQ 358
              P ++TTA   T ++      S     +A  +++  A +   T+   +PS  +LGT   
Sbjct: 3752 GTPHVSTTATTPTVTSSKATPFSSPGTATALPALRSTATTPTATSFTAIPSS-SLGTTWT 3810

Query: 359  QLHTMAQKTIFSTGTPVAA-ATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHS 417
            +L          T TP A  +T  P     T  ++T   + + T   T ++ T +    +
Sbjct: 3811 RLS--------QTTTPTATMSTATPSSTPETAHTSTVLTTTATTTRATGSVATPSSTPGT 3862

Query: 418  SHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDN 477
            +H T V T+      V P     T+                    R  P  ++  T    
Sbjct: 3863 AHTTKVPTTTTTGFTVTPSSSPGTA--------------------RTPPVWISTTTTPTT 3902

Query: 478  RPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVA 537
              S          T  PS+ P   HT T +T++ +T+      + A  S+ T  +G    
Sbjct: 3903 SGS----------TVTPSSVPGTTHTPTVLTTTTTTVA---TGSMATPSSSTQTSGT--- 3946

Query: 538  STVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAP--LGTQGIHSAT 595
                  P  L+T   +            I+  G    P  TPG  P P  L T     A 
Sbjct: 3947 ------PPSLITTATT------------ITATGSTTNPSSTPGTTPIPPVLTTTATTPAA 3988

Query: 596  PINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSA 655
              +T     A +GT    P   T+A     G ++     S+P +   A T+       + 
Sbjct: 3989 TSSTVTPSSA-LGTTHTPPVPNTTATT--HGRSLSP---SSPHTVRTAWTSATSGTLGTT 4042

Query: 656  STNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPP 715
                P+ G+S  P+      AT G    S   +S   P        S++  + P      
Sbjct: 4043 HITEPSTGTSHTPA------ATTGTTQHSTPALSSPHP--------SSRTTESPPSPGTT 4088

Query: 716  TAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITT 756
            T      T  T   A    ++ +  L + P + PIT  +TT
Sbjct: 4089 TPGHTTATSRTTATATPSKTRTSTLLPSSPTSAPITTVVTT 4129



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 109/477 (22%), Positives = 163/477 (34%), Gaps = 38/477 (7%)

Query: 361  HTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHA 420
            H  +     ST TP +      IL   T  +ATT  +   T  P+ST  T   P      
Sbjct: 2973 HCPSTPATSSTATPSSTPGTTWILTEQTT-AATTTATTGSTAIPSSTPGTAPPPK----- 3026

Query: 421  TAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPS 480
               +T+  P A    +  + +SPR     P   S+    +    +P P      +   P 
Sbjct: 3027 VLTSTATTPTA-TSSKATSSSSPRTATTLPVLTSTATKSTATSFTPIPSFTLGTTGTLPE 3085

Query: 481  VPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTV 540
                    + T  PS+ P   HT T +T+  +T R    S+ +  S+    T +    T 
Sbjct: 3086 QTTTPMATMSTIHPSSTPETTHTSTVLTTKATTTRA--TSSMSTPSSTPGTTWILTELTT 3143

Query: 541  HLNPMQLMTVDASHARHIQGIQPAPISTQGI-----QPAPIGTPGIQPAPLGTQGIHSAT 595
                       A+      G    P ST G      +P+   T  +   P G+    S+T
Sbjct: 3144 -----------AATTTAATGPTATPSSTPGTTWILTEPSTTATVTV---PTGSTATASST 3189

Query: 596  PINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSA 655
               T G       T        + A   +   T  A P     +  P AT+V    S S 
Sbjct: 3190 RA-TAGTLKVLTSTATTPTVISSRATPSSSPGTATALPALRSTATTPTATSVTAIPSSSL 3248

Query: 656  STNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPP 715
             T       +  P+      AT  + P++ +H S  T +T +  T     +     + P 
Sbjct: 3249 GTAWTRLSQTTTPTATMST-ATPSSTPET-VHTS--TVLTTTTTTTRATGSVATPSSTPG 3304

Query: 716  TAQQPP-PTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSV 774
            TA     PT  T    A+P S P  AL+        T P T  +   P S+      ++V
Sbjct: 3305 TAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTRGSTVTPSSIPGTTHTATV 3364

Query: 775  LGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLAL--LANNLSMP-TSDLPP 828
            L      +       P    +  S  PP  T T +   A     N  S P T+ +PP
Sbjct: 3365 LTTTTTTVATGSMATPSSSTQ-TSGTPPSLTTTATTITATGSTTNPSSTPGTTPIPP 3420



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 158/689 (22%), Positives = 228/689 (33%), Gaps = 135/689 (19%)

Query: 251  PTSQLPNAATAQPAVQHIIHQPIQS----RPPVTTSNAIPPAVVATVSATRAQSPVITTT 306
            PT++L  A T          QP  S    R P  ++ A+P       S     +    TT
Sbjct: 1615 PTTELETATTTTTQALFSTPQPTSSPGLTRAPPASTTAVPTLSEGLTSPRYTSTLGTATT 1674

Query: 307  AAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHP-ALGTPK-QQLHTMA 364
                T +  + PT+     P  A S         + TR  LP    +LGT +  Q  T+A
Sbjct: 1675 GGPTTPAGSTEPTV-----PGVATST--------LPTRSALPGTTGSLGTWRPSQPPTLA 1721

Query: 365  QKTIF-STGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAV 423
              T+  S   P   A+ A      T  + T    +S +QA TST  T T     S  T  
Sbjct: 1722 PTTMATSRARPTGTASTASKEPLTTSLAPTLTSELSTSQAETSTPRTETT---MSPLTNT 1778

Query: 424  TTSNIPVAKVVPQQITHTSPRIQ------PDYPA--------ERSSLIPISGHRASPNPV 469
            TTS         Q  T   P+ +       D+P         E    I  +G +    P 
Sbjct: 1779 TTS---------QGTTRCQPKCEWTEWFDVDFPTSGVAGGDMETFENIRAAGGKMCWAPK 1829

Query: 470  AMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAIT 529
            ++E R++N P V +                       +T S+ T           N   T
Sbjct: 1830 SIECRAENYPEVSID-----------------QVGQVLTCSLET------GLTCKNEDQT 1866

Query: 530  AQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQ 589
             +  +      + N   L   D SH        PA  ST      P GT  I   P  T 
Sbjct: 1867 GRFNM----CFNYNVRVLCCDDYSHCPST----PATSSTATPSSTP-GTTWILTKPTTTA 1917

Query: 590  GI-----HSATPINTQGLQPAP--MGTQQPQPEGKTS-AVVLADGATIVANPISNPFSAA 641
                    +ATP +T    P P  + T    P   +S A   +   T  A P     +  
Sbjct: 1918 TTTASTGSTATPTSTLRTAPPPKVLTTTATTPTVTSSKATPSSSPGTATALPALRSTATT 1977

Query: 642  PAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETV 701
            P AT+V    S S  T       +  P+      AT  + P++  H S  T +T +  T 
Sbjct: 1978 PTATSVTPIPSSSLGTTWTRLSQTTTPTATMST-ATPSSTPETA-HTS--TVLTATATTT 2033

Query: 702  SNQNNDQPTIAVPPTAQQPP-PTIPTMIAAASPPSQPAVAL------------------- 741
                +     + P TA     PT  T    A+P S P  AL                   
Sbjct: 2034 GATGSVATPSSTPGTAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTRGSTV 2093

Query: 742  --STIPG----AVPITPPITTIA-------------AAPPPSVTVGGSLSSVLGPPVPEI 782
              S+IPG    A  +T   TT+A             +  PPS+T   +  +  G      
Sbjct: 2094 TPSSIPGTTHTATVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITATGSTTNPS 2153

Query: 783  KVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHV 842
                      ++   +  P   +NTV+PS A L    + P  +       R  P    H 
Sbjct: 2154 STPGTTPIPPVLTTTATTPAATSNTVTPSSA-LGTTHTPPVPNTMATTHGRSLPPSSPHT 2212

Query: 843  I-----STEEGDMMETNSTDDEKSTAKSL 866
            +     S   G +  T+ T+    T+ +L
Sbjct: 2213 VRTAWTSATSGILGTTHITEPSTVTSHTL 2241



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 120/532 (22%), Positives = 187/532 (35%), Gaps = 86/532 (16%)

Query: 39   STGLSQAPSQIANSGSAGLI---NPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEP 95
            STG +  PS  +  G+  ++   +  ATV   +G  +  S+ +  + +  + +       
Sbjct: 4436 STGSTATPS--STPGTTWILTEPSTTATVTVPTGSTATASSTQATAGTPHVSTTATTPTV 4493

Query: 96   VVVRPYPQVQMLSTHHAVASATPV---AVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSR 152
               +  P     S+    A+A P      T P A    A+P S          + T P+ 
Sbjct: 4494 TSSKATP-----SSSPGTATALPALRSTATTPTATSFTAIPSSSLGTTWTRLSQTTTPTA 4548

Query: 153  PIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMS 212
             ++ A PS  S P  V     +T  ++   A+   VAT S   G         TT    +
Sbjct: 4549 TMSTATPS--STPETVHTSTVLTATATTTGATG-SVATPSSTPGTAHTTKVPTTTTTGFT 4605

Query: 213  IIRSNAPG----PPLHIGASHLPR-----------------GAAAAAVMSSSKVTTVLRP 251
               S++PG    PP+ I  +  P                  G    A + ++  TTV   
Sbjct: 4606 ATPSSSPGTALTPPVWISTTTTPTTTTPTTSGSTVTPSSIPGTTHTARVLTTTTTTVATG 4665

Query: 252  TSQLPNAATAQPAVQHIIHQPI------------QSRP------PVTTSNAIPPAVVATV 293
            +   P+++T        +                 S P      PV TS A  PA  ++ 
Sbjct: 4666 SMATPSSSTQTSGTPPSLTTTATTITATGSTTNPSSTPGTTPITPVLTSTATTPAATSS- 4724

Query: 294  SATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPAL 353
             AT + SP   TT    T +A      S    PS+ +       ++  T   T+ +    
Sbjct: 4725 KATSSSSPRTATTLPVLTSTATKSTATSFTPIPSSTLWTTWTVPAQTTTPMSTMSTIHTS 4784

Query: 354  GTPKQQLHTMAQKTIFSTGTPVAAATVAP--------ILATNTIPSATTAGS-----VSH 400
             TP +  HT    T  +T T    +T  P        IL   T  + TTA +     +S 
Sbjct: 4785 STP-ETTHTSTVLTTTATMTRATNSTATPSSTLGTTRILTELTTTATTTAATGSTATLSS 4843

Query: 401  TQAPT------STIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERS 454
            T   T      STI T+ VP+ S+   + T       KVV    T          P   +
Sbjct: 4844 TPGTTWILTEPSTIATVMVPTGSTATASSTLGTAHTPKVVTTMAT---------MPTATA 4894

Query: 455  SLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTP 506
            S +P S    +    A+   S    SV       L T  P+ +P ++H  TP
Sbjct: 4895 STVPSSSTVGTTRTPAVLPSSLPTFSVSTVSSSVLTTLRPTGFP-SSHFSTP 4945



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 168/757 (22%), Positives = 245/757 (32%), Gaps = 94/757 (12%)

Query: 130  PAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSL-----PPKVPGQVTVTMESSIPQAS 184
            P+ P + S  +    P  T     +     +T S      P   PG   +  E S     
Sbjct: 2418 PSTPATSSTAMPSSTPGTTWILTELTTTATTTESTGSTATPSSTPGTTWILTEPSTTATV 2477

Query: 185  AIPV---ATISGQQGHPSNLHHIMTTNVQMSIIRSNA-----PGPPLHIGA----SHLPR 232
             +P    AT S  Q   +   H+ TT    ++  S A     PG    + A    +  P 
Sbjct: 2478 TVPTGSTATASSTQA-TAGTPHVSTTATTPTVTSSKATPFSSPGTATALPALRSTATTPT 2536

Query: 233  GAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVAT 292
              +  A+ SSS  TT  R +      AT   A       P  +   V TS  +      T
Sbjct: 2537 ATSFTAIPSSSLGTTWTRLSQTTTPTATMSTAT------PSSTPETVHTSTVLTTTATTT 2590

Query: 293  VSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPA 352
             +     +P  T   AH T   L+  T      PS++    R      ++T  T  +  +
Sbjct: 2591 GATGSVATPSSTPGTAHTT-KVLTTTTTGFTATPSSSPGTARTLPVW-ISTTTTPTTRGS 2648

Query: 353  LGTPKQQLHTMAQKTIFSTGTPVAA----ATVAPILATNTIP-----SATTAGSVSHTQA 403
              TP     T    T+ +T T   A    AT +    T+  P     +ATT  +   T  
Sbjct: 2649 TVTPSSIPGTTHTPTVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITATGSTTN 2708

Query: 404  PTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQI---THTSPRIQPDYPAERSSLIPIS 460
            P+ST  T  +P   +  T  TT     + V P      THT P           SL P S
Sbjct: 2709 PSSTPGTTPIPPVLT--TTATTPAATSSTVTPSSALGTTHTPPVPNTTATTHGRSLSPSS 2766

Query: 461  GHRA-----SPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIR 515
             H       S     + T     PS          ++ P+A        TP  SS     
Sbjct: 2767 PHTVRTAWTSATSGTLGTTHITEPSTGT-------SHTPAATTGTTQHSTPALSSPHPSS 2819

Query: 516  QYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPIST---QGIQ 572
            +   S  +P +     T     +T    P +  T     +        API+T    G +
Sbjct: 2820 RTTESPPSPGTTTPGHTRATSRTTATATPSKTRTSTLLPSSPTS----APITTVVTMGCE 2875

Query: 573  PAPIGTPGIQ---PAPLGTQGIHSATPINTQGLQPA----PMGTQ---QPQPE------G 616
            P    +  +    P P G  G    T  N +    A    P+G +   Q QP       G
Sbjct: 2876 PQCAWSEWLDYSYPMP-GPSGGDFDTYSNIRAAGGAVCEQPLGLECRAQAQPGVPLRELG 2934

Query: 617  KTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPA 676
            +     L  G           F         V   +     + PA  S+  PS      +
Sbjct: 2935 QVVECSLDFGLVCRNREQVGKFKMCFNYEIRVFCCNYGHCPSTPATSSTATPS------S 2988

Query: 677  TDGAKPKSEIHVSMATPVTVSMETVSNQ-NNDQPTIAVPPTAQQPPPTIPTMIAAASPPS 735
            T G    + I     T  T +  T S    +  P  A PP       T PT  ++ +  S
Sbjct: 2989 TPGT---TWILTEQTTAATTTATTGSTAIPSSTPGTAPPPKVLTSTATTPTATSSKATSS 3045

Query: 736  QPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMR 795
                  +T+P         T  +  P PS T+G +        +PE +    +  M  + 
Sbjct: 3046 SSPRTATTLPVLTSTATKSTATSFTPIPSFTLGTT------GTLPE-QTTTPMATMSTIH 3098

Query: 796  PVSAVPPLATNTVSPSLALLAN-NLSMPTSDLPPGAS 831
            P S      T+TV  + A       SM T    PG +
Sbjct: 3099 PSSTPETTHTSTVLTTKATTTRATSSMSTPSSTPGTT 3135



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 114/508 (22%), Positives = 171/508 (33%), Gaps = 74/508 (14%)

Query: 130  PAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSL-----PPKVPGQVTVTMESSIPQAS 184
            P+ P + S       P  T     +     +T S      P   PG   +  E S     
Sbjct: 3675 PSTPATSSTATPSSTPGTTWILTKLTTTATTTESTGSTATPSSTPGTTWILTEPSTTATV 3734

Query: 185  AIPV---ATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMS 241
             +P    AT S  Q   +   H+ TT    ++  S A        A+ LP   + A   +
Sbjct: 3735 TVPTGSTATASSTQA-TAGTPHVSTTATTPTVTSSKATPFSSPGTATALPALRSTATTPT 3793

Query: 242  SSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSP 301
            ++  T +  P+S L    T              + P  T S A P +   T       S 
Sbjct: 3794 ATSFTAI--PSSSLGTTWTRLSQT---------TTPTATMSTATPSSTPETAHT----ST 3838

Query: 302  VITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLH 361
            V+TTTA        +R T S+  P S   +          TT  T+    + GT +    
Sbjct: 3839 VLTTTAT------TTRATGSVATPSSTPGTAHTTKVPTTTTTGFTVTPSSSPGTARTP-- 3890

Query: 362  TMAQKTIFSTGTPVAA-ATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHA 420
                  I +T TP  + +TV P    +++P  T   +V  T   T    +M  PS S+  
Sbjct: 3891 ---PVWISTTTTPTTSGSTVTP----SSVPGTTHTPTVLTTTTTTVATGSMATPSSSTQT 3943

Query: 421  TAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPS 480
            +    S I  A  +    + T+P   P                 +P P  + T +    +
Sbjct: 3944 SGTPPSLITTATTITATGSTTNPSSTPG---------------TTPIPPVLTTTATTPAA 3988

Query: 481  VPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGV--GVAS 538
                      T  PS+     HT  P+ ++ +T     +S  +P++  TA T    G   
Sbjct: 3989 TS-------STVTPSSALGTTHT-PPVPNTTATTHGRSLSPSSPHTVRTAWTSATSGTLG 4040

Query: 539  TVHLNPMQLMT--VDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLG--TQGIHSA 594
            T H+      T    A+     Q   PA  S     P P       P   G  T G  +A
Sbjct: 4041 TTHITEPSTGTSHTPAATTGTTQHSTPALSS-----PHPSSRTTESPPSPGTTTPGHTTA 4095

Query: 595  TPINTQGLQPAPMGTQQPQPEGKTSAVV 622
            T   T    P+   T    P   TSA +
Sbjct: 4096 TSRTTATATPSKTRTSTLLPSSPTSAPI 4123



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 108/478 (22%), Positives = 157/478 (32%), Gaps = 53/478 (11%)

Query: 107  LSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKP----------TMPSRPIAP 156
            +ST H   S+TP          T A     +  +  P   P          T  +   A 
Sbjct: 3094 MSTIHP--SSTPETTHTSTVLTTKATTTRATSSMSTPSSTPGTTWILTELTTAATTTAAT 3151

Query: 157  APPSTLSLPPKVPGQVTVTMESSIPQASAIPV---ATISGQQGHPSNLHHIMTTNVQMSI 213
             P +T   P   PG   +  E S      +P    AT S  +     L  + +T    ++
Sbjct: 3152 GPTAT---PSSTPGTTWILTEPSTTATVTVPTGSTATASSTRATAGTLKVLTSTATTPTV 3208

Query: 214  IRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNA-----ATAQPAVQHI 268
            I S A        A+ LP   + A   +++ VT +  P+S L  A      T  P     
Sbjct: 3209 ISSRATPSSSPGTATALPALRSTATTPTATSVTAI--PSSSLGTAWTRLSQTTTPTATMS 3266

Query: 269  IHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSA 328
               P  +   V TS  +      T +     +P  T   AH T    +  T     P S+
Sbjct: 3267 TATPSSTPETVHTSTVLTTTTTTTRATGSVATPSSTPGTAHTTKVPTTTTTGFTATPSSS 3326

Query: 329  -AISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVA-PILAT 386
               ++  P      TT  T  S     +     HT    T  +T T VA  ++A P  +T
Sbjct: 3327 PGTALTPPVWISTTTTPTTRGSTVTPSSIPGTTHTATVLT--TTTTTVATGSMATPSSST 3384

Query: 387  NT-------IPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQ-- 437
             T         +ATT  +   T  P+ST  T  +P   +  T  TT     + V P    
Sbjct: 3385 QTSGTPPSLTTTATTITATGSTTNPSSTPGTTPIPPVLT--TTATTPAATSSTVTPSSAL 3442

Query: 438  -ITHTSPRIQPDYPAERSSLIPISGHR-----ASPNPVAMETRSDNRPSVPVQFQYFLPT 491
              THT P           SL P S H       S     + T     PS        + +
Sbjct: 3443 GTTHTPPVPNTTATTHGRSLPPSSPHTVRTAWTSATSGILGTTHITEPST-------VTS 3495

Query: 492  YPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMT 549
            + P+A        TP  SS     +   S  +P +     T     +T    P +  T
Sbjct: 3496 HTPAATTSTTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTRGTSRTTATATPSKTRT 3553



 Score = 32.0 bits (71), Expect = 3.1
 Identities = 46/202 (22%), Positives = 78/202 (38%), Gaps = 24/202 (11%)

Query: 639  SAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSM 698
            +  P  TT ++T   + +T   A  S+P+P+     P    A P S          T ++
Sbjct: 1610 ATTPPPTTELET---ATTTTTQALFSTPQPT---SSPGLTRAPPAS----------TTAV 1653

Query: 699  ETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIP--GAVP-ITPPIT 755
             T+S         +   TA    PT P   A ++ P+ P VA ST+P   A+P  T  + 
Sbjct: 1654 PTLSEGLTSPRYTSTLGTATTGGPTTP---AGSTEPTVPGVATSTLPTRSALPGTTGSLG 1710

Query: 756  TIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALL 815
            T   + PP++      +S   P        +  EP+      +    L+T+    S    
Sbjct: 1711 TWRPSQPPTLAPTTMATSRARPTGTASTASK--EPLTTSLAPTLTSELSTSQAETSTPRT 1768

Query: 816  ANNLSMPTSDLPPGASPRKKPR 837
               +S  T+      + R +P+
Sbjct: 1769 ETTMSPLTNTTTSQGTTRCQPK 1790


>gi|83367077 mucin 16 [Homo sapiens]
          Length = 14507

 Score = 84.0 bits (206), Expect = 7e-16
 Identities = 189/839 (22%), Positives = 291/839 (34%), Gaps = 128/839 (15%)

Query: 36    GAPSTGLSQAPSQIANSGSA-------------GLINPAATVNDESGRDSEVSAREHMSS 82
             G P T  S A S  A + S               L+  ++ VN  S     +S  E  ++
Sbjct: 11011 GEPETTPSMATSHGAEASSTVPTVSPEVPGVVTSLVTSSSGVNSTSIPTLILSPGELETT 11070

Query: 83    SSSLQSREEKQEPVVVRPY--PQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGL 140
              S   S   +    V  P   P V  + T    +S    + T P       + LS SE  
Sbjct: 11071 PSMATSHGAEASSAVPTPTVSPGVSGVVTPLVTSSRAVTSTTIP------ILTLSSSE-- 11122

Query: 141   MKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESS-IPQASAIPVATISGQQGHPS 199
               P   P+M +     A  + L++ P+VPG VT  + SS    ++ IP  TIS  +   +
Sbjct: 11123 --PETTPSMATSHGVEASSAVLTVSPEVPGMVTSLVTSSRAVTSTTIPTLTISSDEPETT 11180

Query: 200   NLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAA 259
                   +    +S I + A  P +        +G   + V SS   T+     S L  A+
Sbjct: 11181 TSLVTHSEAKMISAIPTLAVSPTV--------QGLVTSLVTSSGSETSAF---SNLTVAS 11229

Query: 260   TAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPT 319
             +    +   +     + P    S+ +P     TVS     + +   T    + S L R T
Sbjct: 11230 SQPETIDSWV-----AHPGTEASSVVP---TLTVSTGEPFTNISLVTHPAESSSTLPRTT 11281

Query: 320   LSIQHP-----PSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTP 374
                 H      PS   S +  A+S    +    P  P + T            + S+G  
Sbjct: 11282 SRFSHSELDTMPSTVTSPE--AESSSAISTTISPGIPGVLT----------SLVTSSGRD 11329

Query: 375   VAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVV 434
             ++A    P +  +   S  TA  V+H  A TST V  T P++ SH+   TT +I  +   
Sbjct: 11330 ISA--TFPTVPESPHESEATASWVTH-PAVTSTTVPRTTPNY-SHSEPDTTPSIATSPGA 11385

Query: 435   PQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPP 494
                    +  + PD P   +S +  SG   S   +   T S   P     F  +  T+  
Sbjct: 11386 EATSDFPTITVSPDVPDMVTSQVTSSGTDTSIT-IPTLTLSSGEPETTTSFITYSETHTS 11444

Query: 495   SAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASH 554
             SA P                   PVS  A     +     G  ST    P    T     
Sbjct: 11445 SAIP-----------------TLPVSPGASKMLTSLVISSGTDSTTTF-PTLTETPYEPE 11486

Query: 555   ARHIQGIQPAPISTQGIQPAPIGTPGIQ--------PAPLGTQGIHSATPINTQGLQPAP 606
                IQ I PA  +T      P  TP           P  + + G  +++ ++T  + P  
Sbjct: 11487 TTAIQLIHPAETNTM----VPRTTPKFSHSKSDTTLPVAITSPGPEASSAVSTTTISP-- 11540

Query: 607   MGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSAST-------NA 659
                     +  TS V  +   T    P  +     P  T    TH    ST       N 
Sbjct: 11541 -----DMSDLVTSLVPSSGTDTSTTFPTLSETPYEPETTATWLTHPAETSTTVSGTIPNF 11595

Query: 660   PAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQ 719
               +GS   PS++   P  D         +  + P  V+ +  S+  +   + A+P     
Sbjct: 11596 SHRGSDTAPSMV-TSPGVDTRSGVPTTTIPPSIPGVVTSQVTSSATD--TSTAIPTLTPS 11652

Query: 720   PPPTIPTMIAAASPPSQP--AVALSTIPGAVPIT-------PPITTIAAAPPPSVTVGGS 770
             P     T  +A  P +Q    V + T+P + P T       PP T   + P    T   S
Sbjct: 11653 PGEPETTASSATHPGTQTGFTVPIRTVPSSEPDTMASWVTHPPQT---STPVSRTTSSFS 11709

Query: 771   LSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPG 829
              SS    PV     + E     +       P + T+ ++ S A  A + ++PT    PG
Sbjct: 11710 HSSPDATPVMATSPRTEASSAVLTTISPGAPEMVTSQITSSGA--ATSTTVPTLTHSPG 11766



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 180/834 (21%), Positives = 305/834 (36%), Gaps = 112/834 (13%)

Query: 42    LSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPY 101
             +S  P+   +    GL+    T    SG  SE SA  +++ +SS   + E  +  V  P 
Sbjct: 11192 ISAIPTLAVSPTVQGLVTSLVT---SSG--SETSAFSNLTVASS---QPETIDSWVAHPG 11243

Query: 102   PQVQMLSTHHAVASATP---VAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAP 158
              +   +     V++  P   +++   PA  +  +P + S          TMPS   +P  
Sbjct: 11244 TEASSVVPTLTVSTGEPFTNISLVTHPAESSSTLPRTTSR--FSHSELDTMPSTVTSPEA 11301

Query: 159   PST----LSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSII 214
              S+     ++ P +PG +T  + SS    SA             +    +    V  + +
Sbjct: 11302 ESSSAISTTISPGIPGVLTSLVTSSGRDISATFPTVPESPHESEATASWVTHPAVTSTTV 11361

Query: 215   RSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQ------------ 262
                 P    H      P  A +    ++S   T+   +  +P+  T+Q            
Sbjct: 11362 PRTTPNYS-HSEPDTTPSIATSPGAEATSDFPTIT-VSPDVPDMVTSQVTSSGTDTSITI 11419

Query: 263   PAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTA-AHATDSALSRPTLS 321
             P +     +P  +   +T S     + + T+  +   S ++T+   +  TDS  + PTL+
Sbjct: 11420 PTLTLSSGEPETTTSFITYSETHTSSAIPTLPVSPGASKMLTSLVISSGTDSTTTFPTLT 11479

Query: 322   IQ--HPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAAT 379
                  P + AI +  PA++  +  R T         PK   H+ +  T+           
Sbjct: 11480 ETPYEPETTAIQLIHPAETNTMVPRTT---------PKFS-HSKSDTTL----------- 11518

Query: 380   VAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQIT 439
               P+  T+  P A++A S +      S +VT  VPS  +     T++  P     P +  
Sbjct: 11519 --PVAITSPGPEASSAVSTTTISPDMSDLVTSLVPSSGTD----TSTTFPTLSETPYEPE 11572

Query: 440   HTSPRIQPDYPAERSSL----IPISGHRASPNPVAMETRS--DNRPSVPVQFQYFLPTYP 493
              T+  +   +PAE S+     IP   HR S    +M T    D R  VP        T P
Sbjct: 11573 TTATWLT--HPAETSTTVSGTIPNFSHRGSDTAPSMVTSPGVDTRSGVPTT------TIP 11624

Query: 494   PSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDAS 553
             PS   +     T  +S+  T    P    +P    T       +S  H       TV   
Sbjct: 11625 PSIPGVVTSQVT--SSATDTSTAIPTLTPSPGEPETT-----ASSATHPGTQTGFTVPI- 11676

Query: 554   HARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQG----LQPAPMGT 609
               R +   +P  +++    P    TP  +     +     ATP+           A + T
Sbjct: 11677 --RTVPSSEPDTMASWVTHPPQTSTPVSRTTSSFSHSSPDATPVMATSPRTEASSAVLTT 11734

Query: 610   QQP-QPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQS-ASTNAPAQGSSPR 667
               P  PE  TS +  +  AT    P        P  T ++ TH ++  S   PA    P+
Sbjct: 11735 ISPGAPEMVTSQITSSGAATSTTVPTLTHSPGMPETTALLSTHPRTETSKTFPASTVFPQ 11794

Query: 668   PSILRKKPATDGAKPKSEIHVSMATPVTVSMETV----SNQNNDQPTIAVPPTAQQPP-P 722
              S   +  A+   +P +E   ++ T  T S+ T+    +++ +  PT +   +A+  P  
Sbjct: 11795 VS---ETTASLTIRPGAETSTALPTQTTSSLFTLLVTGTSRVDLSPTASPGVSAKTAPLS 11851

Query: 723   TIP-TMIAAASPPSQPAVALSTIPGAVPIT----PPITTIAAAPPPSVTVGGSLSSVLGP 777
             T P T  +   P S  ++ L    G +  +       +T+     P+V+   S S     
Sbjct: 11852 THPGTETSTMIPTSTLSLGLLETTGLLATSSSAETSTSTLTLTVSPAVSGLSSASITTDK 11911

Query: 778   PVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGAS 831
             P        E  P       S  PP  + TV+ +   L  +  MPT   PP  S
Sbjct: 11912 PQTVTSWNTETSP----SVTSVGPPEFSRTVTGTTMTLIPS-EMPT---PPKTS 11957



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 169/799 (21%), Positives = 289/799 (36%), Gaps = 121/799 (15%)

Query: 60    PAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPV 119
             P+   + E+   S +S          L S        +   +P V   S H + A+A+ V
Sbjct: 11293 PSTVTSPEAESSSAISTTISPGIPGVLTSLVTSSGRDISATFPTVPE-SPHESEATASWV 11351

Query: 120   AVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPS--TLSLPPKVPGQVTVTME 177
                A  +   P    ++S    +P   P++ + P A A     T+++ P VP  VT  + 
Sbjct: 11352 THPAVTSTTVPRTTPNYSHS--EPDTTPSIATSPGAEATSDFPTITVSPDVPDMVTSQVT 11409

Query: 178   SSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAA 237
             SS    S I + T++   G P      +T +   +   S  P  P+  GAS +      +
Sbjct: 11410 SSGTDTS-ITIPTLTLSSGEPETTTSFITYSETHT--SSAIPTLPVSPGASKMLTSLVIS 11466

Query: 238   AVMSSSKVTTVLRPTSQLPNAATAQ---PAVQHII---------HQPIQSRPPVTTSNAI 285
             +   S+     L  T   P     Q   PA  + +         H    +  PV  ++  
Sbjct: 11467 SGTDSTTTFPTLTETPYEPETTAIQLIHPAETNTMVPRTTPKFSHSKSDTTLPVAITSPG 11526

Query: 286   PPA--VVATVSATRAQSPVITTTA-AHATDSALSRPTLSIQ--HPPSAAISIQRPAQSRD 340
             P A   V+T + +   S ++T+   +  TD++ + PTLS     P + A  +  PA++  
Sbjct: 11527 PEASSAVSTTTISPDMSDLVTSLVPSSGTDTSTTFPTLSETPYEPETTATWLTHPAET-S 11585

Query: 341   VTTRITLP--SH------PAL----------GTPKQQLHTMAQKTIFS--TGTPVAAATV 380
              T   T+P  SH      P++          G P   +       + S  T +    +T 
Sbjct: 11586 TTVSGTIPNFSHRGSDTAPSMVTSPGVDTRSGVPTTTIPPSIPGVVTSQVTSSATDTSTA 11645

Query: 381   APILATNTIPSATTAGSVSHTQAPTS-TIVTMTVPSH-----SSHATAVTTSNIPVAKVV 434
              P L  +     TTA S +H    T  T+   TVPS      +S  T    ++ PV++  
Sbjct: 11646 IPTLTPSPGEPETTASSATHPGTQTGFTVPIRTVPSSEPDTMASWVTHPPQTSTPVSRTT 11705

Query: 435   PQQITHTSPRIQPDYPA----ERSSLIPISGHRASPNPVAME-TRSDNRPSVPVQFQYFL 489
                 +H+SP   P        E SS +  +    +P  V  + T S    S  V      
Sbjct: 11706 -SSFSHSSPDATPVMATSPRTEASSAVLTTISPGAPEMVTSQITSSGAATSTTVPTLTHS 11764

Query: 490   PTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAIT---AQTGVGVASTVHLNPMQ 546
             P  P +   L+ H  T  + +      +P  ++   S      A+T   + +    +   
Sbjct: 11765 PGMPETTALLSTHPRTETSKTFPASTVFPQVSETTASLTIRPGAETSTALPTQTTSSLFT 11824

Query: 547   LMTVDASHARHIQGIQPAPISTQGI--QPAPIGT-PGIQPAPLGTQGIHSATPINTQGLQ 603
             L+    S       +  +P ++ G+  + AP+ T PG + + +      S   + T GL 
Sbjct: 11825 LLVTGTSR------VDLSPTASPGVSAKTAPLSTHPGTETSTMIPTSTLSLGLLETTGLL 11878

Query: 604   PAPMG----------TQQPQPEGKTSAVVLADGATIVA--NPISNP---------FSAAP 642
                            T  P   G +SA +  D    V   N  ++P         FS   
Sbjct: 11879 ATSSSAETSTSTLTLTVSPAVSGLSSASITTDKPQTVTSWNTETSPSVTSVGPPEFSRTV 11938

Query: 643   AATTVVQTHSQSASTNAPAQGSSPRPSILRKKP-------ATDGAKPK--------SEIH 687
               TT+    S+  +    + G    P+ + +         AT G+ P         + + 
Sbjct: 11939 TGTTMTLIPSEMPTPPKTSHGEGVSPTTILRTTMVEATNLATTGSSPTVAKTTTTFNTLA 11998

Query: 688   VSMATPVTV-SMETVSNQN-------NDQPTIAVPP-------TAQQPPPTIPTMIAAAS 732
              S+ TP+T   M T+++++       N +  I+          T     P   T     S
Sbjct: 11999 GSLFTPLTTPGMSTLASESVTSRTSYNHRSWISTTSSYNRRYWTPATSTPVTSTFSPGIS 12058

Query: 733   PPSQPAVALSTIPGAVPIT 751
               S P+   +T+P  VP T
Sbjct: 12059 TSSIPSSTAATVPFMVPFT 12077



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 191/918 (20%), Positives = 332/918 (36%), Gaps = 126/918 (13%)

Query: 6    HPQAGEIEAGGAGGGRR---LQVEMSSQQFPRLG-------APSTGLSQAPSQIANSGSA 55
            H +   + + GAG   R   L VE +S    +L        +P +    A S  +++   
Sbjct: 7364 HSEITTLVSRGAGDVPRPSSLPVEETSPPSSQLSLSAMISPSPVSSTLPASSHSSSASVT 7423

Query: 56   GLINPAATVNDE---SGRDSEVSAREHMSSSSS--LQSREEKQEPVVVRPYPQVQMLSTH 110
             L+ P      E   +  + E S+   +SS+S   L + E   +   + P+    +    
Sbjct: 7424 SLLTPGQVKTTEVLDASAEPETSSPPSLSSTSVEILATSEVTTDTEKIHPFSNTAVTKVG 7483

Query: 111  HAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMP-----SRPIAPAPPSTLSLP 165
             + +     +   P +  T A     +  +M      T+      +R I   P S+L+  
Sbjct: 7484 TSSSGHESPSSVLPDSETTKATSAMGTISIMGDTSVSTLTPALSNTRKIQSEPASSLTTR 7543

Query: 166  PKVPGQVTVTMESSIP-QASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLH 224
             +   + + + E+S+  +A+ +     +G     S    I  +   MS    +     + 
Sbjct: 7544 LR---ETSTSEETSLATEANTVLSKVSTGATTEVSRTEAISFSRTSMSGPEQSTMSQDIS 7600

Query: 225  IGASHLPRGAAAAAVMSSSKVT---------TVLRPTSQLPNAATAQPAVQHIIHQPIQS 275
            IG   +PR +A++ +  S+K+T         + L  T  L  A T      H I      
Sbjct: 7601 IGT--IPRISASSVLTESAKMTITTQTGPSESTLESTLNLNTATTPSWVETHSIVIQGFP 7658

Query: 276  RPPVTTS-----------------NAIPPAVVATVSATRAQSPVITTTAAHATDSALSRP 318
             P +TTS                    PP+   ++ A  +  PV TT  AH   S L   
Sbjct: 7659 HPEMTTSMGRGPGGVSWPSPPFVKETSPPSSPLSLPAVTSPHPVSTTFLAHIPPSPLPVT 7718

Query: 319  TLSIQHPPSAAISIQRPAQ-SRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAA 377
            +L    P +    +    +     ++ ++  SH  L T K   HT A     +TG     
Sbjct: 7719 SLLTSGPATTTDILGTSTEPGTSSSSSLSTTSHERLTTYKDTAHTEAVHPSTNTG----- 7773

Query: 378  ATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQ 437
                    TN   +++   S S   A +S + T +    +S  T+ T + +   ++  + 
Sbjct: 7774 -------GTNVATTSSGYKSQSSVLADSSPMCTTSTMGDTSVLTS-TPAFLETRRIQTEL 7825

Query: 438  ITHTSPRIQPDYPAERSSLIPISGHRAS------PNPVAMETRSDNRPSVPVQFQYFLPT 491
             +  +P ++    +E +S    SG + S      P     E   ++  S+P         
Sbjct: 7826 ASSLTPGLRESSGSEGTS----SGTKMSTVLSKVPTGATTEISKEDVTSIP--------- 7872

Query: 492  YPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVD 551
              P+   ++    T   S  ST      SA+   +  T+  G     T  L+     ++ 
Sbjct: 7873 -GPAQSTISPDISTRTVSWFSTSPVMTESAEITMNTHTSPLGATTQGTSTLDTSSTTSLT 7931

Query: 552  ASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQ 611
             +H+   QG   + +ST  ++  P     + P PL    +    P  +    PA   T  
Sbjct: 7932 MTHSTISQGFSHSQMSTL-MRRGPEDVSWMSP-PL----LEKTRPSFSLMSSPA---TTS 7982

Query: 612  PQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSIL 671
            P P   T    L +  +    P+++  ++  A TT +   S    TN+PA  SS    IL
Sbjct: 7983 PSPVSST----LPESISSSPLPVTSLLTSGLAKTTDMLHKSSEPVTNSPANLSSTSVEIL 8038

Query: 672  RKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAA 731
                 T   +   + H S    VT   +  ++ +  + T  V   +Q    T P +I   
Sbjct: 8039 ATSEVTTDTE---KTHPSSNRTVT---DVGTSSSGHESTSFVLADSQTSKVTSPMVI--T 8090

Query: 732  SPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVG-GSLSSVLGPPVPEIKVKEEVEP 790
            S     +V+ ST PG        + I   P  S+T+G    SS  G  +           
Sbjct: 8091 STMEDTSVSTST-PGFF----ETSRIQTEPTSSLTLGLRKTSSSEGTSL----------A 8135

Query: 791  MDIMRPVSAVPPLATNTVSPSLALLANNLSM---PTSDLPPGASPRKKPRKQQHVISTEE 847
             ++   +S VP  AT  VS +    ++  S+       + P  S     R     I TE 
Sbjct: 8136 TEMSTVLSGVPTGATAEVSRTEVTSSSRTSISGFAQLTVSPETSTETITRLPTSSIMTES 8195

Query: 848  GDMMETNSTDDEKSTAKS 865
             +MM    TD   ST +S
Sbjct: 8196 AEMMIKTQTDPPGSTPES 8213



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 155/810 (19%), Positives = 302/810 (37%), Gaps = 129/810 (15%)

Query: 135  SFSEGLMKPPPKPTMPSRPIAPAPPSTL-SLPPKVPGQVTVTMESSIPQASAIPVATISG 193
            SFS  LM   P P M S P++   P T+ + P  +   +T ++  +       P  T S 
Sbjct: 6800 SFSSSLM---PSPAMTSPPVSSTLPKTIHTTPSPMTSLLTPSLVMTTDTLGTSPEPTTSS 6856

Query: 194  QQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTS 253
                 S  H I+TT+   + I +  P                     S+S   T +  TS
Sbjct: 6857 PPNLSSTSHEILTTDEDTTAIEAMHP---------------------STSTAATNVETTS 6895

Query: 254  QLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDS 313
                + ++  A      +  ++  P+ T++ +    V+T  +  +++  I   + ++   
Sbjct: 6896 SGHGSQSSVLADS----EKTKATAPMDTTSTMGHTTVSTSMSVSSETTKIKRESTYSLTP 6951

Query: 314  ALSRPTLSIQHPPSAAISI---------QRPAQSRDVTT--RITLPSHPALGTPKQQLHT 362
             L   ++S     S   SI                +VT+  R ++P  P+  T   ++ T
Sbjct: 6952 GLRETSISQNASFSTDTSIVLSEVPTGTTAEVSRTEVTSSGRTSIPG-PSQSTVLPEIST 7010

Query: 363  MAQKTIFSTGTPVAAATVAPILATNTIPSATTA-------GSVSHTQAPTSTIVTMTVPS 415
                 +F++ T   +A +   + T T PS +T+        S + +QA T + +T   P 
Sbjct: 7011 RTMTRLFASPTMTESAEMT--IPTQTGPSGSTSQDTLTLDTSTTKSQAKTHSTLTQRFP- 7067

Query: 416  HSSHATAVTTSNIPVAKVVPQQITHTS--PRI----QPDYPAERSSLIPISGHRASPNPV 469
            HS   T ++     ++      + + S  P +        P   SS +P++    S +P+
Sbjct: 7068 HSEMTTLMSRGPGDMSWQSSPSLENPSSLPSLLSLPATTSPPPISSTLPVT---ISSSPL 7124

Query: 470  AMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHT----------------YTPITSSVST 513
             + +   + P       +  P    S+ P  +HT                  P T++ ++
Sbjct: 7125 PVTSLLTSSPVTTTDMLHTSPELVTSSPPKLSHTSDERLTTGKDTTNTEAVHPSTNTAAS 7184

Query: 514  IRQYPVSA-QAPNSAITAQTGVGVASTVHLNPMQ---LMTVDASHARHIQGIQPAPISTQ 569
              + P S  ++P+SA+         S + +   Q    + +   H      IQ   IS+ 
Sbjct: 7185 NVEIPSSGHESPSSALADSETSKATSPMFITSTQEDTTVAISTPHFLETSRIQKESISSL 7244

Query: 570  GIQPAPIGTPGIQPAPLGTQGIHSATPIN----------TQGLQPAPMGTQQPQ--PEGK 617
              +    G+     + + T  + S   I           T   + +  G+ +    PE  
Sbjct: 7245 SPKLRETGSSVETSSAIETSAVLSEVSIGATTEISRTEVTSSSRTSISGSAESTMLPEIS 7304

Query: 618  T--------SAVVLADGATIVANPISNPFSAAPAATTVVQT------------------H 651
            T        ++ +LA+ + +     ++P  +   +T  + T                  H
Sbjct: 7305 TTRKIIKFPTSPILAESSEMTIKTQTSPPGSTSESTFTLDTSTTPSLVITHSTMTQRLPH 7364

Query: 652  SQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVS-MATPVTVSMETVSNQNNDQPT 710
            S+  +  +   G  PRPS L   P  + + P S++ +S M +P  VS    ++ ++   +
Sbjct: 7365 SEITTLVSRGAGDVPRPSSL---PVEETSPPSSQLSLSAMISPSPVSSTLPASSHSSSAS 7421

Query: 711  IAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPP----SVT 766
            +    T  Q   T   + A+A P +    +LS+    +  T  +TT      P    +VT
Sbjct: 7422 VTSLLTPGQ-VKTTEVLDASAEPETSSPPSLSSTSVEILATSEVTTDTEKIHPFSNTAVT 7480

Query: 767  VGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDL 826
              G+ SS    P   +   E  +    M  +S +   + +T++P+L+      S P S L
Sbjct: 7481 KVGTSSSGHESPSSVLPDSETTKATSAMGTISIMGDTSVSTLTPALSNTRKIQSEPASSL 7540

Query: 827  PPGASPRKKPRKQQHVISTEEGDMMETNST 856
                  R+    ++  ++TE   ++   ST
Sbjct: 7541 T--TRLRETSTSEETSLATEANTVLSKVST 7568



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 199/895 (22%), Positives = 334/895 (37%), Gaps = 110/895 (12%)

Query: 38   PSTGLSQAPSQIANSGSAGLINPAATVNDE--SGRDSEVSAREHMSSSSSLQSREEKQEP 95
            P++ L+    + ++S         +TV  E  SG  +EVS  E +SS  +  S  ++   
Sbjct: 8410 PTSSLTSGLRETSSSERISSATEGSTVLSEVPSGATTEVSRTEVISSRGTSMSGPDQFTI 8469

Query: 96   VVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEG-LMKPPPKPTMPSRPI 154
                    +  LST   +  +   A+T     +    P + SEG L       T  S   
Sbjct: 8470 SPDISTEAITRLSTSPIMTESAESAIT-----IETGSPGATSEGTLTLDTSTTTFWSGTH 8524

Query: 155  APAPPS-----TLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNV 209
            + A P        +L  + PG V      S+ +AS++     S     P+     MT+  
Sbjct: 8525 STASPGFSHSEMTTLMSRTPGDVPWPSLPSVEEASSV-----SSSLSSPA-----MTSTS 8574

Query: 210  QMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRP-----TSQLPNAATAQPA 264
              S +       P  I +S  P    A   +   K T +LR      TS  PN ++    
Sbjct: 8575 FFSTL-------PESISSS--PHPVTALLTLGPVKTTDMLRTSSEPETSSPPNLSSTSAE 8625

Query: 265  V---------QHIIHQPIQSRPPVTTSNAI-----PPAVVATVSATRAQSPVITTTAAHA 310
            +         +  IH P  + P V     I     P +V+A +  T+  SP+ TT+    
Sbjct: 8626 ILATSEVTKDREKIH-PSSNTPVVNVGTVIYKHLSPSSVLADLVTTKPTSPMATTSTLGN 8684

Query: 311  TDSALSRPTL---SIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKT 367
            T  + S P      +  P S+  S  R   +   T+  T  S    G P      +++  
Sbjct: 8685 TSVSTSTPAFPETMMTQPTSSLTSGLREISTSQETSSATERSASLSGMPTGATTKVSRTE 8744

Query: 368  IFS---TGTP-VAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAV 423
              S   T TP  A +T++P ++T TI   +T  + + +   T T  T    + S     +
Sbjct: 8745 ALSLGRTSTPGPAQSTISPEISTETITRISTPLTTTGSAEMTITPKTGHSGASSQGTFTL 8804

Query: 424  TTSNIPVAKVVPQQITHTSPRIQPDYPAER-----SSLIPISGHRASPNPVAMETRSDNR 478
             TS+           TH SP      P  R     S     S  + SP    +   +   
Sbjct: 8805 DTSSRASWPGTHSAATHRSPHSGMTTPMSRGPEDVSWPSRPSVEKTSPPSSLVSLSAVTS 8864

Query: 479  PSVPVQFQYFLPTYPPSAYPL-AAHTYTPI---TSSVSTIRQYPVSAQAPNSAITAQTGV 534
            PS P+   Y  P+    + PL     +TP+   T+ +      PV+   P+  IT+   +
Sbjct: 8865 PS-PL---YSTPSESSHSSPLRVTSLFTPVMMKTTDMLDTSLEPVTTSPPSMNITSDESL 8920

Query: 535  GVA-STVHLNPMQLMTVDA-SHARHIQGIQPAPISTQGI-QPAPIGTPGIQPAPLGTQGI 591
              + +T+    +QL    A +    I   Q    S  G+ +P+ + +P +  + +    +
Sbjct: 8921 ATSKATMETEAIQLSENTAVTQMGTISARQEFYSSYPGLPEPSKVTSPVVTSSTI-KDIV 8979

Query: 592  HSATPINTQ--GLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQ 649
             +  P +++   ++     T  P P  +TS       AT    P + P+ A  +A T+  
Sbjct: 8980 STTIPASSEITRIEMESTSTLTPTPR-ETSTSQEIHSAT---KPSTVPYKALTSA-TIED 9034

Query: 650  THSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHV-SMATPVTVSMETVSNQNNDQ 708
            + +Q  S+   ++G SP  S + +  +T+     S   + + +T +T++ +T S     +
Sbjct: 9035 SMTQVMSS---SRGPSPDQSTMSQDISTEVITRLSTSPIKTESTEMTITTQTGSPGATSR 9091

Query: 709  PTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVG 768
             T+ +  +      T  T     S  SQ    +S  PG VP             PSV   
Sbjct: 9092 GTLTLDTSTTFMSGTHSTASQGFS-HSQMTALMSRTPGDVP---------WLSHPSVEEA 9141

Query: 769  GSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVS-PSLALLANNLSMPTSDLP 827
             S S  L  PV           M    PVS+  P + ++ S P  +LL + L   T  L 
Sbjct: 9142 SSASFSLSSPV-----------MTSSSPVSSTLPDSIHSSSLPVTSLLTSGLVKTTELLG 9190

Query: 828  PGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYID 882
              + P           S E   + E  +TD EK    +++      +SP     D
Sbjct: 9191 TSSEPETSSPPNLSSTSAEILAITEV-TTDTEKLEMTNVVTSGYTHESPSSVLAD 9244



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 178/881 (20%), Positives = 312/881 (35%), Gaps = 171/881 (19%)

Query: 95   PVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLS--FSEGLMKPPPKPTMPSR 152
            P++ +  P   ++S+  A  S +PV+ T P +  +  +P++   + GL K        S 
Sbjct: 7963 PLLEKTRPSFSLMSSP-ATTSPSPVSSTLPESISSSPLPVTSLLTSGLAKTTDMLHKSSE 8021

Query: 153  PI--APAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLH-------- 202
            P+  +PA  S+ S+      +VT   E + P ++       +   GH S           
Sbjct: 8022 PVTNSPANLSSTSVEILATSEVTTDTEKTHPSSNRTVTDVGTSSSGHESTSFVLADSQTS 8081

Query: 203  -----HIMTTNVQMSIIRSNAPG---------PPLHIGASHLPRGAAAAAVMSSSKVTTV 248
                  ++T+ ++ + + ++ PG          P       L + +++     +++++TV
Sbjct: 8082 KVTSPMVITSTMEDTSVSTSTPGFFETSRIQTEPTSSLTLGLRKTSSSEGTSLATEMSTV 8141

Query: 249  LRPTSQLPNAATAQ-----------PAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSA-- 295
            L   S +P  ATA+            ++       +       T   +P + + T SA  
Sbjct: 8142 L---SGVPTGATAEVSRTEVTSSSRTSISGFAQLTVSPETSTETITRLPTSSIMTESAEM 8198

Query: 296  ---TRAQSPVITTTAAHATDSAL--------SRPTLSIQHPPSAAISIQRPAQS------ 338
               T+   P  T  + H  D +         S  T    H     +  + P         
Sbjct: 8199 MIKTQTDPPGSTPESTHTVDISTTPNWVETHSTVTQRFSHSEMTTLVSRSPGDMLWPSQS 8258

Query: 339  --RDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNT-------- 388
               + ++  +L S PA  +P     T+ +   F + +    + + P L   T        
Sbjct: 8259 SVEETSSASSLLSLPATTSPSPVSSTLVED--FPSASLPVTSLLNPGLVITTDRMGISRE 8316

Query: 389  --IPSATTAGSVSHT--------------QAPTSTIVT---MTVPSHSSHATAVTTSNIP 429
                S +   S SH               Q  T T VT    ++  H S ++ ++ S  P
Sbjct: 8317 PGTSSTSNLSSTSHERLTTLEDTVDTEDMQPSTHTAVTNVRTSISGHESQSSVLSDSETP 8376

Query: 430  VAKVVPQQITHT------SPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPV 483
             A   P   T+T      S      +   R  + P S   +       ET S  R S   
Sbjct: 8377 KA-TSPMGTTYTMGETSVSISTSDFFETSRIQIEPTSSLTSG----LRETSSSERISSAT 8431

Query: 484  QFQYFLPTYPPSAYPLAAHT-----------------YTP--ITSSVSTIRQYPVSAQAP 524
            +    L   P  A    + T                  +P   T +++ +   P+  ++ 
Sbjct: 8432 EGSTVLSEVPSGATTEVSRTEVISSRGTSMSGPDQFTISPDISTEAITRLSTSPIMTESA 8491

Query: 525  NSAITAQTGVGVAS---TVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGI 581
             SAIT +TG   A+   T+ L+         +H+    G   + ++T   +     TPG 
Sbjct: 8492 ESAITIETGSPGATSEGTLTLDTSTTTFWSGTHSTASPGFSHSEMTTLMSR-----TPGD 8546

Query: 582  QPAPLGTQGIHSATPINTQGLQPAPMGTQ--QPQPEGKTSAVVLADGATIVANPISNPFS 639
             P P     +  A+ +++    PA   T      PE  +S+           +P++   +
Sbjct: 8547 VPWP-SLPSVEEASSVSSSLSSPAMTSTSFFSTLPESISSS----------PHPVTALLT 8595

Query: 640  AAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSME 699
              P  TT +   S    T++P   SS    IL     T   K + +IH S  TPV V++ 
Sbjct: 8596 LGPVKTTDMLRTSSEPETSSPPNLSSTSAEILATSEVT---KDREKIHPSSNTPV-VNVG 8651

Query: 700  TVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAA 759
            TV  ++    ++       +  PT P  +A  S     +V+ ST     P  P   T+  
Sbjct: 8652 TVIYKHLSPSSVLADLVTTK--PTSP--MATTSTLGNTSVSTST-----PAFP--ETMMT 8700

Query: 760  APPPSVTVGGSLSSVLGPPVPEIKVKEEV-EPMDIMRPVSAVPPLATNTVSPSLALLANN 818
             P  S+T G          + EI   +E     +    +S +P  AT  VS + AL    
Sbjct: 8701 QPTSSLTSG----------LREISTSQETSSATERSASLSGMPTGATTKVSRTEALSLGR 8750

Query: 819  LSMP---TSDLPPGASPRKKPRKQQHVISTEEGDMMETNST 856
             S P    S + P  S     R    + +T   +M  T  T
Sbjct: 8751 TSTPGPAQSTISPEISTETITRISTPLTTTGSAEMTITPKT 8791



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 182/866 (21%), Positives = 306/866 (35%), Gaps = 173/866 (19%)

Query: 52   SGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQ------SREEKQEPVVVRPYPQVQ 105
            S S  L++ A+ + D+    S  S   H  ++SS+       S + K    V+       
Sbjct: 721  STSIPLLSSASVLEDKVSATSTFS---HHKATSSITTGTPEISTKTKPSSAVLSSMTLSN 777

Query: 106  MLSTHHAVASAT-PVAVTAPPAHLTPAVPLSFS---EGLMKPPPKPTMPSRPIAPAPPST 161
              ++   V +AT P+   +P    T    L+ S   E    P   PT      +   PST
Sbjct: 778  AATSPERVRNATSPLTHPSPSGEETAGSVLTLSTSAETTDSPNIHPTGTLTSESSESPST 837

Query: 162  LSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPS-NLHHIMTTNVQMSIIRSNAPG 220
            LSLP  V G V  T  SS P          + +  +PS +      + V+ ++  ++ P 
Sbjct: 838  LSLP-SVSG-VKTTFSSSTPSTHLFTSGEETEETSNPSVSQPETSVSRVRTTLASTSVPT 895

Query: 221  PPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLP---NAATAQPAVQHIIHQPIQSRP 277
            P        +      +A  SSS + + LR TS      +  +A P + H+      S+ 
Sbjct: 896  PVFPT----MDTWPTRSAQFSSSHLVSELRATSSTSVTNSTGSALPKISHLTGTATMSQT 951

Query: 278  PVTTSN--AIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRP 335
               T N  A P +     ++ R ++ + + T   +T +     T+ +    S       P
Sbjct: 952  NRDTFNDSAAPQSTTWPETSPRFKTGLPSATTTVSTSATSLSATVMVSKFTS-------P 1004

Query: 336  AQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAP-ILATNTIPSATT 394
            A S    T I  PS   L T  +  +      + ST  P+    +    L T+ +P  TT
Sbjct: 1005 ATSSMEATSIREPSTTILTT--ETTNGPGSMAVASTNIPIGKGYITEGRLDTSHLPIGTT 1062

Query: 395  AGS---VSHTQAPTSTIVTMTVPSHSSHATAVTTSN----------------------IP 429
            A S   +  T A  S  ++++ PS S  A   +T                        IP
Sbjct: 1063 ASSETSMDFTMAKESVSMSVS-PSQSMDAAGSSTPGRTSQFVDTFSDDVYHLTSREITIP 1121

Query: 430  ---VAKVVPQQITHTSPRIQPDYPAERSSLIPI-SGHRASPNPVA--------------- 470
                +  +  Q+T T P   PD  + RS+ + I S   +SP P                 
Sbjct: 1122 RDGTSSALTPQMTATHPP-SPDPGSARSTWLGILSSSPSSPTPKVTMSSTFSTQRVTTSM 1180

Query: 471  ----METRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITS------------SVSTI 514
                +ET   N P++P       P+  P++  +   T  P+ +             + T+
Sbjct: 1181 IMDTVETSRWNMPNLPSTTS-LTPSNIPTSGAIGKSTLVPLDTPSPATSLEASEGGLPTL 1239

Query: 515  RQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPA 574
              YP S   P+  + A       ST+ L    +             ++P   +       
Sbjct: 1240 STYPESTNTPSIHLGAHASSESPSTIKLTMASV-------------VKPGSYT------- 1279

Query: 575  PIGTPGIQPAPLGTQGIHSATP--INTQGLQP---APMGTQQPQPEGKTSAVVLADGATI 629
            P+  P I+        IH +T     + G  P   AP  T        T+ +   D    
Sbjct: 1280 PLTFPSIE------THIHVSTARMAYSSGSSPEMTAPGETNTGSTWDPTTYITTTDPKDT 1333

Query: 630  VANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPS--------ILRKKPATDGAK 681
             +  +S P S     TT  + H ++ S    A   SP+ S          +    TD  +
Sbjct: 1334 SSAQVSTPHSVRTLRTT--ENHPKTESATPAAYSGSPKISSSPNLTSPATKAWTITDTTE 1391

Query: 682  PKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTI--PTMIAAASPPSQPAV 739
              +++H +     +   ET   Q+   P   V PT+    PTI   T+   +  P +P V
Sbjct: 1392 HSTQLHYTKLAEKSSGFET---QSAPGPVSVVIPTS----PTIGSSTLELTSDVPGEPLV 1444

Query: 740  ALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSA 799
                                AP    T+   +++ L   + E     +   +DI  P S 
Sbjct: 1445 -------------------LAPSEQTTITLPMATWLSTSLTEEMASTD---LDISSPSS- 1481

Query: 800  VPPLATNTVSPSLALLANNLSMPTSD 825
              P++T  + P ++  ++ LS   +D
Sbjct: 1482 --PMSTFAIFPPMSTPSHELSKSEAD 1505



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 186/873 (21%), Positives = 306/873 (35%), Gaps = 182/873 (20%)

Query: 33   PRLGAPSTGLS-QAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREE 91
            P    PST  S   P+       A +  P +   D  G  +  S       +S+LQ    
Sbjct: 4556 PVSSEPSTATSPMVPASSMGDALASISIPGSETTDIEGEPTS-SLTAGRKENSTLQEMNS 4614

Query: 92   KQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPS 151
              E  ++     V       A+  AT + V +  A   P    S      K P   ++ S
Sbjct: 4615 TTESNIILSNVSVG------AITEATKMEVPSFDATFIPTPAQS-----TKFPDIFSVAS 4663

Query: 152  RPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVA----TISGQQGHPSNL-----H 202
              ++ +PP T+S        +T T   S    S IP+A    T+    G PS +     H
Sbjct: 4664 SRLSNSPPMTIST------HMTTTQTGSSGATSKIPLALDTSTLETSAGTPSVVTEGFAH 4717

Query: 203  HIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQ 262
              +TT +   +   +   PP    AS                      P+SQ P   T  
Sbjct: 4718 SKITTAMNNDVKDVSQTNPPFQDEASS---------------------PSSQAPVLVTTL 4756

Query: 263  PAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSI 322
            P+      Q   +  PV+ S+ +  ++V T               A   D++L   T S 
Sbjct: 4757 PSSVAFTPQWHSTSSPVSMSSVLTSSLVKT---------------AGKVDTSLETVTSS- 4800

Query: 323  QHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAP 382
              P S + ++   + +   TT I   +HP++ T            + + GT  +A     
Sbjct: 4801 --PQSMSNTLDDISVTSAATTDIE-TTHPSINT-----------VVTNVGTTGSAFESHS 4846

Query: 383  ILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHA---TAVTTSNIPVAK--VVPQQ 437
             ++    PS  T+ +V+ T     T ++ ++P  S      T  T+S  P  +   + Q+
Sbjct: 4847 TVSAYPEPSKVTSPNVT-TSTMEDTTISRSIPKSSKTTRTETETTSSLTPKLRETSISQE 4905

Query: 438  ITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAY 497
            IT ++           +S +P      +   V   +R+D   S    F    P     + 
Sbjct: 4906 ITSST----------ETSTVPYKELTGATTEV---SRTDVTSSSSTSFPG--PDQSTVSL 4950

Query: 498  PLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARH 557
             ++  T T +++S       P+  ++    IT QTG   A++         T+D S+   
Sbjct: 4951 DISTETNTRLSTS-------PIMTESAEITITTQTGPHGATS-----QDTFTMDPSNT-- 4996

Query: 558  IQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGK 617
                                TP          GIHSA       L    + ++ PQ    
Sbjct: 4997 --------------------TP--------QAGIHSAMTHGFSQLDVTTLMSRIPQDVSW 5028

Query: 618  TSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPAT 677
            TS        ++      + F ++PA T    T S  +ST    + SSP  S+L     T
Sbjct: 5029 TSP------PSVDKTSSPSSFLSSPAMT----TPSLISSTLPEDKLSSPMTSLL-----T 5073

Query: 678  DGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIA-------- 729
             G    ++I  +   PVT S+   S+ ++    +A    ++      P++          
Sbjct: 5074 SGLVKITDILRTRLEPVTSSLPNFSSTSD--KILATSKDSKDTKEIFPSINTEETNVKAN 5131

Query: 730  -AASPPSQPAVALSTIPGAVPITPPITTIA-AAPPPSVTVGGSLSSV---------LGPP 778
             +      PA+A S  P A       TT+   AP  S+ V GS  +          L P 
Sbjct: 5132 NSGHESHSPALADSETPKATTQMVITTTVGDPAPSTSMPVHGSSETTNIKREPTYFLTPR 5191

Query: 779  VPEIKVKEEVE-PMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSD---LPPGASPRK 834
            + E    +E   P D    +S VP      VS +    ++ +S P  D   +PP     +
Sbjct: 5192 LRETSTSQESSFPTDTSFLLSKVPTGTITEVSSTGVNSSSKISTPDHDKSTVPPDTFTGE 5251

Query: 835  KPRKQQHVISTEEGDMMETNSTDDEKSTAKSLL 867
             PR     I T+  +M  T      +S + S L
Sbjct: 5252 IPRVFTSSIKTKSAEMTITTQASPPESASHSTL 5284



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 146/747 (19%), Positives = 255/747 (34%), Gaps = 104/747 (13%)

Query: 128   LTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIP 187
             L  + P+ FS          T+P+     +  +T        G  + T E  +   S + 
Sbjct: 10324 LPSSTPVPFSSSTFTTTDSSTIPALHEITSSSATPYRVDTSLGTESSTTEGRLVMVSTLD 10383

Query: 188   VATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTT 247
              ++  G+      L   MT +V++  + S    P L   ++ L R               
Sbjct: 10384 TSSQPGRTSSSPILDTRMTESVELGTVTSAYQVPSL---STRLTR------------TDG 10428

Query: 248   VLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTA 307
             ++   +++PN A  +  ++ +       + P T+++   P  + T    R ++   TTTA
Sbjct: 10429 IMEHITKIPNEAAHRGTIRPV-------KGPQTSTSPASPKGLHTGGTKRMET---TTTA 10478

Query: 308   AHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSH---PALGTPKQQLHTMA 364
                T +AL                          T+R TL +    P LGT      +M 
Sbjct: 10479 LKTTTTALK------------------------TTSRATLTTSVYTPTLGTLTPLNASMQ 10514

Query: 365   QKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVT 424
               +   T   +    V P +   T   AT+ G+ + T  P +T       S ++ A+ V+
Sbjct: 10515 MASTIPTEMMITTPYVFPDVPETTSSLATSLGAETSTALPRTTPSVFNRESETT-ASLVS 10573

Query: 425   TSNIPVAKVVPQ-QITHTSPRIQPDYPAERSSLIPISGHRASPN--PVAMETRSDNRPSV 481
              S    + V+    ++ + P     +    +  IP    + +PN     ++T S    S 
Sbjct: 10574 RSGAERSPVIQTLDVSSSEPDTTASWVIHPAETIPTVS-KTTPNFFHSELDTVSSTATSH 10632

Query: 482   PVQFQYFLPTYPPSAYPLAAHTYTPIT--SSVSTIRQYPVSAQAPNSAITAQTGVG-VAS 538
                    +PT   +  P      TP+   S   T   +P   ++P+   T  T +   A 
Sbjct: 10633 GADVSSAIPT---NISPSELDALTPLVTISGTDTSTTFPTLTKSPHETETRTTWLTHPAE 10689

Query: 539   TVHLNPMQLMTVDASHARHIQGIQPAP-ISTQGIQPAPIGTPGI------QPAPLGTQGI 591
             T    P  +       +     I  +P   T    P    +PG       Q    GT   
Sbjct: 10690 TSSTIPRTIPNFSHHESDATPSIATSPGAETSSAIPIMTVSPGAEDLVTSQVTSSGTDRN 10749

Query: 592   HSATPINTQGLQPAPMGTQQPQPEGKTSAVVLAD------------------GATIVANP 633
              +   +     +P  + +    PE +TS+ +                       T   N 
Sbjct: 10750 MTIPTLTLSPGEPKTIASLVTHPEAQTSSAIPTSTISPAVSRLVTSMVTSLAAKTSTTNR 10809

Query: 634   ISNPFSAAPAATTVVQTHSQSASTNAPAQGS---SPRPSILRKKPATDGAKPKSEIH--- 687
                     PA T  + TH    S   P   S     +         + GA+  S +    
Sbjct: 10810 ALTNSPGEPATTVSLVTHPAQTSPTVPWTTSIFFHSKSDTTPSMTTSHGAESSSAVPTPT 10869

Query: 688   VSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGA 747
             VS   P  V+    S++     TI +   +   P T P+M  +    +  A+   T+   
Sbjct: 10870 VSTEVPGVVTPLVTSSRAVISTTIPILTLSPGEPETTPSMATSHGEEASSAIPTPTVSPG 10929

Query: 748   VP--ITPPITTIAAAPPPSVTVGGSLSSVLGPP--VPEIKVKEEVEPMDIMRPV-SAVPP 802
             VP  +T  +T+  A    ++ +   L+  LG P   P +      E    +  V   VP 
Sbjct: 10930 VPGVVTSLVTSSRAVTSTTIPI---LTFSLGEPETTPSMATSHGTEAGSAVPTVLPEVPG 10986

Query: 803   LATNTVSPSLALLANNLSMPTSDLPPG 829
             + T+ V+ S A+ +  L  PT  L PG
Sbjct: 10987 MVTSLVASSRAVTSTTL--PTLTLSPG 11011



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 187/864 (21%), Positives = 301/864 (34%), Gaps = 121/864 (14%)

Query: 27    MSSQQFPRLGAPSTG-----LSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMS 81
             +S+   P     STG     LS+A +  A +G    I         SG  S  S  E   
Sbjct: 10262 LSTDLLPSAETISTGTVMPSLSEAMTSFATTGVPRAI---------SGSGSPFSRTESGP 10312

Query: 82    SSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTP-AVPLSFSEGL 140
               ++L +  E        P+      +T    +S  P       +  TP  V  S     
Sbjct: 10313 GDATLSTIAESLPSSTPVPFSSSTFTTTD---SSTIPALHEITSSSATPYRVDTSLGTES 10369

Query: 141   MKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTME-SSIPQASAIP-----VATISGQ 194
                  +  M S     + P   S  P +  ++T ++E  ++  A  +P     +    G 
Sbjct: 10370 STTEGRLVMVSTLDTSSQPGRTSSSPILDTRMTESVELGTVTSAYQVPSLSTRLTRTDGI 10429

Query: 195   QGH----PSNLHHIMTTNVQMSIIRSNAPGPP--LHIGASHLPRGAAAAAVMSSSKVTTV 248
               H    P+   H  T         S +P  P  LH G +        A   +++ + T 
Sbjct: 10430 MEHITKIPNEAAHRGTIRPVKGPQTSTSPASPKGLHTGGTKRMETTTTALKTTTTALKTT 10489

Query: 249   LRPTSQL----PNAATAQPAVQHI-IHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVI 303
              R T       P   T  P    + +   I +   +TT    P     T S   +     
Sbjct: 10490 SRATLTTSVYTPTLGTLTPLNASMQMASTIPTEMMITTPYVFPDVPETTSSLATSLGAET 10549

Query: 304   TTTAAHATDSALSRPTLSIQHPPSAAISIQRPA-QSRDVT-----TRITLPSHPALGTPK 357
             +T     T S  +R + +     S + + + P  Q+ DV+     T  +   HPA   P 
Sbjct: 10550 STALPRTTPSVFNRESETTASLVSRSGAERSPVIQTLDVSSSEPDTTASWVIHPAETIPT 10609

Query: 358   QQLHT-----MAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMT 412
                 T         T+ ST T    A V+  + TN  PS   A +   T + T T  T  
Sbjct: 10610 VSKTTPNFFHSELDTVSSTATS-HGADVSSAIPTNISPSELDALTPLVTISGTDTSTTFP 10668

Query: 413   VPSHSSHAT----------AVTTSNIPVAKVVPQQITHTS---PRIQPDYPAERSSLIPI 459
               + S H T          A T+S IP  + +P    H S   P I     AE SS IPI
Sbjct: 10669 TLTKSPHETETRTTWLTHPAETSSTIP--RTIPNFSHHESDATPSIATSPGAETSSAIPI 10726

Query: 460   SGHRASPNP----VAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIR 515
                  SP       +  T S    ++ +      P  P +   L  H     +S++ T  
Sbjct: 10727 M--TVSPGAEDLVTSQVTSSGTDRNMTIPTLTLSPGEPKTIASLVTHPEAQTSSAIPTST 10784

Query: 516   QYPVSAQAPNSAITAQTGVGVASTVHL--NPMQLMTVDASHARHIQGIQPAPISTQGIQP 573
               P  ++   S +T+       +   L  +P +  T  +      Q     P +T     
Sbjct: 10785 ISPAVSRLVTSMVTSLAAKTSTTNRALTNSPGEPATTVSLVTHPAQTSPTVPWTTSIFFH 10844

Query: 574   APIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVAN- 632
             +   T    P+   + G  S++ +        P  T   +  G  + +V +  A I    
Sbjct: 10845 SKSDTT---PSMTTSHGAESSSAV--------PTPTVSTEVPGVVTPLVTSSRAVISTTI 10893

Query: 633   PISNPFSAAPAATTVVQT-HSQSASTNAPAQGSSPR-PSILRKKPATDGAKPKSEIHV-- 688
             PI       P  T  + T H + AS+  P    SP  P ++     +  A   + I +  
Sbjct: 10894 PILTLSPGEPETTPSMATSHGEEASSAIPTPTVSPGVPGVVTSLVTSSRAVTSTTIPILT 10953

Query: 689   -SMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGA 747
              S+  P T    +++  +  +   AVP    + P  + +++A     S  AV  +T+P  
Sbjct: 10954 FSLGEPETTP--SMATSHGTEAGSAVPTVLPEVPGMVTSLVA-----SSRAVTSTTLP-T 11005

Query: 748   VPITP--PITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLAT 805
             + ++P  P TT    P  + + G   SS +    PE                  VP + T
Sbjct: 11006 LTLSPGEPETT----PSMATSHGAEASSTVPTVSPE------------------VPGVVT 11043

Query: 806   NTVSPSLALLANNLSMPTSDLPPG 829
             + V+ S  +  N+ S+PT  L PG
Sbjct: 11044 SLVTSSSGV--NSTSIPTLILSPG 11065



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 161/738 (21%), Positives = 255/738 (34%), Gaps = 142/738 (19%)

Query: 78   EHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFS 137
            E  SSSSSL        P        + + S  H+ +S  PV           +V LS +
Sbjct: 4154 EETSSSSSLVPIHATTSP------SNILLTSQGHSPSSTPPVT----------SVFLSET 4197

Query: 138  EGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGH 197
             GL K      +   P    PP+  S      G+   T E+S    +             
Sbjct: 4198 SGLGKTTDMSRISLEPGTSLPPNLSS----TAGEALSTYEASRDTKA------------- 4240

Query: 198  PSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPN 257
               +HH   T V      S+   P       H     A + +++S  +  +   TS   +
Sbjct: 4241 ---IHHSADTAVTNMEATSSEYSPI----PGHTKPSKATSPLVTSHIMGDITSSTSVFGS 4293

Query: 258  AATAQPAVQHIIHQPIQSRPP--VTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSAL 315
            + T +      ++Q +Q R    V +S      V+  VS+  A + V  T A  ++ +++
Sbjct: 4294 SETTEIETVSSVNQGLQERSTSQVASSATETSTVITHVSSGDATTHVTKTQATFSSGTSI 4353

Query: 316  SRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPV 375
            S P   I               +   T   T PS   + T    +      TI +   P 
Sbjct: 4354 SSPHQFI-------------TSTNTFTDVSTNPSTSLIMTESSGV------TITTQTGPT 4394

Query: 376  AAATVAP-ILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVV 434
             AAT  P +L T+T+P  T             T + +T     S  T + +         
Sbjct: 4395 GAATQGPYLLDTSTMPYLT------------ETPLAVTPDFMQSEKTTLISKG------- 4435

Query: 435  PQQITHTSPR--IQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTY 492
            P+ ++ TSP    +  YP   SSL P      +  P A  T      S PV     L + 
Sbjct: 4436 PKDVSWTSPPSVAETSYP---SSLTPFL---VTTIPPATSTLQGQHTSSPVSATSVLTSG 4489

Query: 493  PPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAIT-----------AQTGVGVASTVH 541
                  +   +  P+T+S   +        A  +A T           A T +G AS+ H
Sbjct: 4490 LVKTTDMLNTSMEPVTNSPQNLNNPSNEILATLAATTDIETIHPSINKAVTNMGTASSAH 4549

Query: 542  LNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQG 601
            +      T+  S           P S+ G   A I  PG +   +  +   S T    + 
Sbjct: 4550 VLHS---TLPVSSEPSTATSPMVPASSMGDALASISIPGSETTDIEGEPTSSLTAGRKEN 4606

Query: 602  LQPAPMGTQQPQPEGKTSAVVLAD---GATIVANPISNP-----FSAAPAATTV---VQT 650
                   T Q       S ++L++   GA   A  +  P     F   PA +T    + +
Sbjct: 4607 ------STLQEMNSTTESNIILSNVSVGAITEATKMEVPSFDATFIPTPAQSTKFPDIFS 4660

Query: 651  HSQSASTNAPAQGSSPRPSILRKKPATDGAKPK-------SEIHVSMATPVTVS-----M 698
             + S  +N+P    S    +   +  + GA  K       S +  S  TP  V+      
Sbjct: 4661 VASSRLSNSPPMTISTH--MTTTQTGSSGATSKIPLALDTSTLETSAGTPSVVTEGFAHS 4718

Query: 699  ETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIA 758
            +  +  NND     V   +Q  PP       A+SP SQ  V ++T+P +V  TP   + +
Sbjct: 4719 KITTAMNND-----VKDVSQTNPPF---QDEASSPSSQAPVLVTTLPSSVAFTPQWHSTS 4770

Query: 759  AAPPPSVTVGGSLSSVLG 776
            +    S  +  SL    G
Sbjct: 4771 SPVSMSSVLTSSLVKTAG 4788



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 176/782 (22%), Positives = 295/782 (37%), Gaps = 168/782 (21%)

Query: 38   PSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVV 97
            PST LS+A S    SG +G+ NP++T              E    S++  S  +++ P  
Sbjct: 2065 PSTSLSEALS----SGHSGVSNPSSTTT------------EFPLFSAASTSAAKQRNPET 2108

Query: 98   VRPYPQVQMLSTHHAVASA-TPVAVTAPPAHLTPAVPLSFS-------EGL-MKPPPKPT 148
                PQ    ST +  AS+ T ++ T   A ++  VPL  +        GL  +    P+
Sbjct: 2109 ETHGPQNTAASTLNTDASSVTGLSETPVGASISSEVPLPMAITSRSDVSGLTSESTANPS 2168

Query: 149  MPSRPIAPAP-PSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTT 207
            + +   A      T+SLP      V+  M    P   +IP+ +      HP       TT
Sbjct: 2169 LGTASSAGTKLTRTISLPTS-ESLVSFRMNKD-PWTVSIPLGS------HP-------TT 2213

Query: 208  NVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQH 267
            N + S I  N+ GPP                      ++TV       P+          
Sbjct: 2214 NTETS-IPVNSAGPP---------------------GLSTVASDVIDTPSDGA------- 2244

Query: 268  IIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPS 327
                  +S P V+ S + P   V T+S    ++     T +  T    SR T       S
Sbjct: 2245 ------ESIPTVSFSPS-PDTEVTTISHFPEKTTHSFRTISSLTHELTSRVTPIPGDWMS 2297

Query: 328  AAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATN 387
            +A+S +    S  +T          LG          ++TI S     AA T +PI+ T 
Sbjct: 2298 SAMSTKPTGASPSIT----------LG---------ERRTITS-----AAPTTSPIVLTA 2333

Query: 388  TIPSATTAGSVSHTQAPTSTIV----TMTVPSHSSHA-----TAVTTSNIPVAK---VVP 435
            +    +T    + T   TS I+    T  +PS SS +     T++ +S + V K   + P
Sbjct: 2334 SFTETSTVSLDNETTVKTSDILDARKTNELPSDSSSSSDLINTSIASSTMDVTKTASISP 2393

Query: 436  QQIT----HTSPRI----QPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQY 487
              I+     +SP +    +P  P   +     +    S N  +++  S N    P     
Sbjct: 2394 TSISGMTASSSPSLFSSDRPQVPTSTTETNTATSPSVSSNTYSLDGGS-NVGGTPSTLPP 2452

Query: 488  FLPTYPPS------AYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQ-TGVGVASTV 540
            F  T+P        A+     T++ + S+ +   + P S+ +  +++ A  T   V ST 
Sbjct: 2453 FTITHPVETSSALLAWSRPVRTFSTMVSTDTASGENPTSSNSVVTSVPAPGTWTSVGSTT 2512

Query: 541  HLNPMQLMTVD---ASHARHIQGIQPAPISTQGIQPAPI-GTPGIQPAPLGT----QGIH 592
             L  M  +       +H+     I+PA   T  +  A + G+     A L T    + IH
Sbjct: 2513 DLPAMGFLKTSPAGEAHSLLASTIEPATAFTPHLSAAVVTGSSATSEASLLTTSESKAIH 2572

Query: 593  SA-----TPIN-----TQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAP 642
            S+     TP +     T     + +   +      TS +++ D  TI+ + +S P S  P
Sbjct: 2573 SSPQTPTTPTSGANWETSATPESLLVVTETSDTTLTSKILVTD--TILFSTVSTPPSKFP 2630

Query: 643  AATTVVQTHSQSASTNAPA---QGSSPRPSILRKKPATD---------GAKPKSEIHVS- 689
            +  T+      +   + PA     + P  S+     +T          G  P++ + +S 
Sbjct: 2631 STGTLSGASFPTLLPDTPAIPLTATEPTSSLATSFDSTPLVTIASDSLGTVPETTLTMSE 2690

Query: 690  MATPVTVSMETVSNQNNDQPTIAVPPTAQ---QPPPTIPTMIAA---ASPPSQPAVALST 743
             +    + ++TVSN +   P I +    +    P  T P+ I A    +      VALST
Sbjct: 2691 TSNGDALVLKTVSNPDRSIPGITIQGVTESPLHPSSTSPSKIVAPRNTTYEGSITVALST 2750

Query: 744  IP 745
            +P
Sbjct: 2751 LP 2752



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 176/834 (21%), Positives = 282/834 (33%), Gaps = 152/834 (18%)

Query: 78    EHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLS-- 135
             E  SSSSSL S      P V    PQ    S+    +  TP  V        P   LS  
Sbjct: 10016 EKTSSSSSLLSLPVTTSPSVSSTLPQSIPSSSFSVTSLLTPGMVKTTDTSTEPGTSLSPN 10075

Query: 136   --------FSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESS---IPQAS 184
                      +   +    +   PS  +A     T S   ++   V++  E S    P  +
Sbjct: 10076 LSGTSVEILAASEVTTDTEKIHPSSSMAVTNVGTTSSGHELYSSVSIHSEPSKATYPVGT 10135

Query: 185   AIPVATISGQQGHPSNLH----------HIMT----TNVQM---SIIRSNAPGPPLHIGA 227
                +A  S     P+N            H+ +    TN+ +   S+  +N P  P   G+
Sbjct: 10136 PSSMAETSISTSMPANFETTGFEAEPFSHLTSGFRKTNMSLDTSSVTPTNTPSSP---GS 10192

Query: 228   SHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIP- 286
             +HL + +      S+   +    P SQ          +   I  P  + P +T S  I  
Sbjct: 10193 THLLQSSKTDFTSSAKTSSPDWPPASQYTE-------IPVDIITPFNASPSITESTGITS 10245

Query: 287   -PAVVATVSATRAQSPVIT--TTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTT 343
              P    T+S T +   + T    +A    +    P+LS      A  S       R ++ 
Sbjct: 10246 FPESRFTMSVTESTHHLSTDLLPSAETISTGTVMPSLS-----EAMTSFATTGVPRAISG 10300

Query: 344   RITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAAT-------VAPILATNTIPSA---- 392
               +  S    G     L T+A+    ST  P +++T         P L   T  SA    
Sbjct: 10301 SGSPFSRTESGPGDATLSTIAESLPSSTPVPFSSSTFTTTDSSTIPALHEITSSSATPYR 10360

Query: 393   --TTAGSVSHTQ----APTSTIVTMTVPSHSSHATAVTT--------SNIPVAKVVPQ-- 436
               T+ G+ S T        ST+ T + P  +S +  + T          +  A  VP   
Sbjct: 10361 VDTSLGTESSTTEGRLVMVSTLDTSSQPGRTSSSPILDTRMTESVELGTVTSAYQVPSLS 10420

Query: 437   -QITHTSPRIQ-----PDYPAERSSLIPISGHRASPNPVA-----------METRSDNRP 479
              ++T T   ++     P+  A R ++ P+ G + S +P +           MET +    
Sbjct: 10421 TRLTRTDGIMEHITKIPNEAAHRGTIRPVKGPQTSTSPASPKGLHTGGTKRMETTTTALK 10480

Query: 480   SVPVQFQ-YFLPTYPPSAYPLAAHTYTPITSSVSTIRQYP---------VSAQAPNSAIT 529
             +     +     T   S Y     T TP+ +S+      P         V    P +  +
Sbjct: 10481 TTTTALKTTSRATLTTSVYTPTLGTLTPLNASMQMASTIPTEMMITTPYVFPDVPETTSS 10540

Query: 530   AQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPI----GTPGIQPAP 585
               T +G  ++  L P    +V    +     +    +S  G + +P+         +P  
Sbjct: 10541 LATSLGAETSTAL-PRTTPSVFNRESETTASL----VSRSGAERSPVIQTLDVSSSEPDT 10595

Query: 586   LGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAAT 645
               +  IH A  I T           +      T+    AD ++ +   IS   S   A T
Sbjct: 10596 TASWVIHPAETIPTVSKTTPNFFHSELDTVSSTATSHGADVSSAIPTNISP--SELDALT 10653

Query: 646   TVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEI---------HVSMATP--- 693
              +V       ST  P    SP  +  R    T  A+  S I         H S ATP   
Sbjct: 10654 PLVTISGTDTSTTFPTLTKSPHETETRTTWLTHPAETSSTIPRTIPNFSHHESDATPSIA 10713

Query: 694   --------VTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPP----------- 734
                       + + TVS    D  T  V  +      TIPT+  +   P           
Sbjct: 10714 TSPGAETSSAIPIMTVSPGAEDLVTSQVTSSGTDRNMTIPTLTLSPGEPKTIASLVTHPE 10773

Query: 735   --SQPAVALSTIPGAVP--ITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKV 784
               +  A+  STI  AV   +T  +T++AA    + T   +L++  G P   + +
Sbjct: 10774 AQTSSAIPTSTISPAVSRLVTSMVTSLAA---KTSTTNRALTNSPGEPATTVSL 10824



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 182/877 (20%), Positives = 309/877 (35%), Gaps = 161/877 (18%)

Query: 25   VEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLI--------NPAATVNDESGRDSEVSA 76
            VE S    P L  PST  S  PS I  SG+ G          +PA ++    G    +S 
Sbjct: 1185 VETSRWNMPNL--PST-TSLTPSNIPTSGAIGKSTLVPLDTPSPATSLEASEGGLPTLST 1241

Query: 77   REHMSSSSSLQ--SREEKQEPV--------VVRP-------YPQVQ----MLSTHHAVAS 115
                +++ S+   +    + P         VV+P       +P ++    + +   A +S
Sbjct: 1242 YPESTNTPSIHLGAHASSESPSTIKLTMASVVKPGSYTPLTFPSIETHIHVSTARMAYSS 1301

Query: 116  ATPVAVTAPPAHLTPAV--PLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVT 173
             +   +TAP    T +   P ++   +    PK T  ++   P    TL      P   +
Sbjct: 1302 GSSPEMTAPGETNTGSTWDPTTY---ITTTDPKDTSSAQVSTPHSVRTLRTTENHPKTES 1358

Query: 174  VTME--SSIPQASAIP--------VATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGP-- 221
             T    S  P+ S+ P          TI+    H + LH+             +APGP  
Sbjct: 1359 ATPAAYSGSPKISSSPNLTSPATKAWTITDTTEHSTQLHYTKLAEKSSGFETQSAPGPVS 1418

Query: 222  -----PLHIGASHLPRGA---AAAAVMSSSKVTTVLRP--------------TSQLPNAA 259
                    IG+S L   +       V++ S+ TT+  P              ++ L  ++
Sbjct: 1419 VVIPTSPTIGSSTLELTSDVPGEPLVLAPSEQTTITLPMATWLSTSLTEEMASTDLDISS 1478

Query: 260  TAQPAVQHIIHQPIQS-RPPVTTSNAIPPAVVATVSATRAQ------------------S 300
             + P     I  P+ +    ++ S A   A+  T S T  Q                  +
Sbjct: 1479 PSSPMSTFAIFPPMSTPSHELSKSEADTSAIRNTDSTTLDQHLGIRSLGRTGDLTTVPIT 1538

Query: 301  PVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSH-----PALGT 355
            P+ TT  +    S  ++ TLS    P+    + +  + +        PSH     P LGT
Sbjct: 1539 PLTTTWTSVIEHSTQAQDTLSATMSPT---HVTQSLKDQTSIPASASPSHLTEVYPELGT 1595

Query: 356  PKQQLHTMAQKTIF---STGTPVAAATVAPILATNTIP-SATTAGSVSH----------- 400
               Q  + ++ T F   ST T        P    +T P   TT GS S            
Sbjct: 1596 ---QGRSSSEATTFWKPSTDTLSREIETGPTNIQSTPPMDNTTTGSSSSGVTLGIAHLPI 1652

Query: 401  -TQAPTSTIVTMTVPSHSSHATA--VTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLI 457
             T +P  T   M +   SS AT     T  + V     + I+ +  R+        +  +
Sbjct: 1653 GTSSPAETSTNMALERRSSTATVSMAGTMGLLVTSAPGRSISQSLGRVSSVLSESTTEGV 1712

Query: 458  PISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTP----------I 507
              S   +SP    + T+ +   S  ++  Y   +   ++ PL +   TP           
Sbjct: 1713 TDSSKGSSPR---LNTQGNTALSSSLEPSYAEGSQMSTSIPLTSSPTTPDVEFIGGSTFW 1769

Query: 508  TSSVSTIRQYPVSAQAPNSAITAQT--GVGVASTVHLNPMQLMTVDASHARHIQGIQPAP 565
            T  V+T+    +S  +  +  ++ T     + ST +    +L T           ++  P
Sbjct: 1770 TKEVTTVMTSDISKSSARTESSSATLMSTALGSTENTGKEKLRTASMDLPSPTPSMEVTP 1829

Query: 566  ISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLAD 625
              +  +  AP  T  +      + G+H+++           + T +    G T A  L +
Sbjct: 1830 WISLTLSNAPNTTDSLDL----SHGVHTSS--------AGTLATDRSLNTGVTRASRLEN 1877

Query: 626  GATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSE 685
            G+   +  +S   S     T++  T     S++   +  +  P       +T G +  S 
Sbjct: 1878 GSDTSSKSLSMGNS---THTSMTYTEKSEVSSSIHPRPETSAPGAETTLTSTPGNRAISL 1934

Query: 686  IHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQP--PPTIP-TMIAAASPPSQPAVALS 742
                 + PV    E +S      P I   P    P  PPTI  T        +QP  A+S
Sbjct: 1935 TLPFSSIPVE---EVISTGITSGPDINSAPMTHSPITPPTIVWTSTGTIEQSTQPLHAVS 1991

Query: 743  TIPGAVPI--TPPITTIAAAPPP----SVTVGGSLSS 773
            +   +V    TP + ++A +  P    SV+ G S SS
Sbjct: 1992 SEKVSVQTQSTPYVNSVAVSASPTHENSVSSGSSTSS 2028



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 175/819 (21%), Positives = 305/819 (37%), Gaps = 154/819 (18%)

Query: 78   EHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFS 137
            E  SSSSSL S      P +  P P          V +  P +  + P HLT ++P S  
Sbjct: 6506 EKTSSSSSLLSL-----PAITSPSP----------VPTTLPESRPSSPVHLT-SLPTS-- 6547

Query: 138  EGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPG-----QVTVTMESSIPQASAIPVATIS 192
             GL+K     T     +A  PP+  S   K+P      + T  M  S   A      T S
Sbjct: 6548 -GLVKT----TDMLASVASLPPNLGSTSHKIPTTSEDIKDTEKMYPSTNIAVTNVGTTTS 6602

Query: 193  GQQGH--------PSNLHHIMTT--NVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSS 242
             ++ +        P  +   M T  N++ +I+ ++ PG      +S + R      + S+
Sbjct: 6603 EKESYSSVPAYSEPPKVTSPMVTSFNIRDTIVSTSMPG------SSEITR----IEMEST 6652

Query: 243  SKVTTVLR--PTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQS 300
              +   L+   TSQ P  +T + AV H +           T+ A   +     S+ R   
Sbjct: 6653 FSLAHGLKGTSTSQDPIVSTEKSAVLHKL-----------TTGATETSRTEVASSRRTSI 6701

Query: 301  PVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQL 360
            P       H+T+S    P +S +  PS  IS+    +S ++T  I   + P LG+  Q  
Sbjct: 6702 P----GPDHSTES----PDISTEVIPSLPISLGI-TESSNMT--IITRTGPPLGSTSQGT 6750

Query: 361  HTMAQKTIFSTGTPVAAATVA-------------PILATNTIPSATTAGSVSHTQAP--- 404
             T+   T  S     + AT               P + + TIP +    S S +  P   
Sbjct: 6751 FTLDTPTTSSRAGTHSMATQEFPHSEMTTVMNKDPEILSWTIPPSIEKTSFSSSLMPSPA 6810

Query: 405  -TSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHR 463
             TS  V+ T+P       +  TS +  + V+      TSP      P   SS    + H 
Sbjct: 6811 MTSPPVSSTLPKTIHTTPSPMTSLLTPSLVMTTDTLGTSPEPTTSSPPNLSS----TSHE 6866

Query: 464  ---ASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVS 520
                  +  A+E    +  +     +     +   +  LA    T  T+ + T      +
Sbjct: 6867 ILTTDEDTTAIEAMHPSTSTAATNVETTSSGHGSQSSVLADSEKTKATAPMDTTSTMGHT 6926

Query: 521  AQAPNSAITAQ-TGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTP 579
              + + +++++ T +   ST  L P               G++   IS    Q A   T 
Sbjct: 6927 TVSTSMSVSSETTKIKRESTYSLTP---------------GLRETSIS----QNASFSTD 6967

Query: 580  G---IQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISN 636
                +   P GT    S T + + G    P         G + + VL + +T        
Sbjct: 6968 TSIVLSEVPTGTTAEVSRTEVTSSGRTSIP---------GPSQSTVLPEIST-------R 7011

Query: 637  PFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTV 696
              +   A+ T+ ++   +  T     GS+ + + L    +T  ++ K+   ++   P + 
Sbjct: 7012 TMTRLFASPTMTESAEMTIPTQTGPSGSTSQDT-LTLDTSTTKSQAKTHSTLTQRFPHSE 7070

Query: 697  SMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITP-PIT 755
                +S    D    + P  + + P ++P++++  +  S P ++ ST+P  +  +P P+T
Sbjct: 7071 MTTLMSRGPGDMSWQSSP--SLENPSSLPSLLSLPATTSPPPIS-STLPVTISSSPLPVT 7127

Query: 756  TIAAAPPPSVT--VGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLA 813
            ++  + P + T  +  S   V   P       +E       R  +      T  V PS  
Sbjct: 7128 SLLTSSPVTTTDMLHTSPELVTSSPPKLSHTSDE-------RLTTGKDTTNTEAVHPSTN 7180

Query: 814  LLANNLSMPTS--DLPPGA---SPRKKPRKQQHVISTEE 847
              A+N+ +P+S  + P  A   S   K      + ST+E
Sbjct: 7181 TAASNVEIPSSGHESPSSALADSETSKATSPMFITSTQE 7219



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 157/810 (19%), Positives = 286/810 (35%), Gaps = 125/810 (15%)

Query: 109   THHAVASATPVAVTAPPAHLTP---AVPLSFSEGLMKPPPKPTMPSRPIAPAP----PST 161
             TH A     P +V   P    P   + P   S     PP      S   +P+P    PS 
Sbjct: 9395  THSATTQRFPQSVVTTPMSRGPEDVSWPSPLSVEKNSPPSSLVSSSSVTSPSPLYSTPSG 9454

Query: 162   LSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGP 221
              S    VP  VT    S + +A+ +  A++  +     N++  +T++  ++  ++     
Sbjct: 9455  SSHSSPVP--VTSLFTSIMMKATDMLDASLEPETTSAPNMN--ITSDESLAASKATTETE 9510

Query: 222   PLHI----GASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRP 277
              +H+     ASH+   +A   + SSS   +   PT  +    T+     +++   +    
Sbjct: 9511  AIHVFENTAASHVETTSATEELYSSSPGFS--EPTKVISPVVTSSSIRDNMVSTTMPGSS 9568

Query: 278   PVT-----TSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISI 332
              +T     + +++ P +  T ++    S   T+T  +   S  +      +  PS+  SI
Sbjct: 9569  GITRIEIESMSSLTPGLRETRTSQDITSSTETSTVLYKMPSGATPEVSRTEVMPSSRTSI 9628

Query: 333   QRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSA 392
               PAQS   T  + +            + T + +   +T T  + AT             
Sbjct: 9629  PGPAQS---TMSLDISDEVVTRLSTSPIMTESAEITITTQTGYSLAT------------- 9672

Query: 393   TTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIP-VAKVVPQQITHTSPR-IQPDYP 450
                   S    P  T +T    +HS+ +  ++ S +  +    P+ ++ TSPR ++    
Sbjct: 9673  ------SQVTLPLGTSMTFLSGTHSTMSQGLSHSEMTNLMSRGPESLSWTSPRFVETTRS 9726

Query: 451   AERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSS 510
             +   + +P++    S +PV+  T  D+ PS P+     +         +   +  P TSS
Sbjct: 9727  SSSLTSLPLT---TSLSPVS-STLLDSSPSSPLPVTSLILPGLVKTTEVLDTSSEPKTSS 9782

Query: 511   VSTIRQYPVSAQAPN-----------SAITAQTGVGVASTVHLNPMQLMT---------- 549
                +    V   A +           S+ TA   V  +S+VH +   ++           
Sbjct: 9783  SPNLSSTSVEIPATSEIMTDTEKIHPSSNTAVAKVRTSSSVHESHSSVLADSETTITIPS 9842

Query: 550   ---VDASHARHIQGIQPAPISTQGIQPAPIG--TPGIQPAPLG--------TQGIHSATP 596
                  A     +    PA   T+ I   P    TPG +             T  +    P
Sbjct: 9843  MGITSAVDDTTVFTSNPAFSETRRIPTEPTFSLTPGFRETSTSEETTSITETSAVLYGVP 9902

Query: 597   IN--TQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQS 654
              +  T+      M + +        + +  D  T V   +S+  S+  + +T +   +Q 
Sbjct: 9903  TSATTEVSMTEIMSSNRIHIPDSDQSTMSPDIITEVITRLSS--SSMMSESTQMTITTQK 9960

Query: 655   ASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMET--------VSNQNN 706
             +S  A AQ +    +       T    P   +H  M T ++ S E         V   ++
Sbjct: 9961  SSPGATAQSTLTLATTTAPLARTHSTVPPRFLHSEMTTLMSRSPENPSWKSSLFVEKTSS 10020

Query: 707   DQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVT 766
                 +++P T     P++ + +  + P S  +V     PG V  T            S  
Sbjct: 10021 SSSLLSLPVTTS---PSVSSTLPQSIPSSSFSVTSLLTPGMVKTT----------DTSTE 10067

Query: 767   VGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTS-- 824
              G SLS  L     EI    EV                T  + PS ++   N+   +S  
Sbjct: 10068 PGTSLSPNLSGTSVEILAASEV-------------TTDTEKIHPSSSMAVTNVGTTSSGH 10114

Query: 825   DLPPGASPRKKPRKQQHVISTEEGDMMETN 854
             +L    S   +P K  + + T    M ET+
Sbjct: 10115 ELYSSVSIHSEPSKATYPVGT-PSSMAETS 10143



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 167/852 (19%), Positives = 304/852 (35%), Gaps = 125/852 (14%)

Query: 106  MLSTH--HAVASATPVAVTAPPAHLTPAVP------LSFSEGLMKPPPKPTMPSRPIAPA 157
            M  TH   ++   T +  +A P+HLT   P       S SE      P     SR I   
Sbjct: 1562 MSPTHVTQSLKDQTSIPASASPSHLTEVYPELGTQGRSSSEATTFWKPSTDTLSREIETG 1621

Query: 158  PPSTLSLPPKVPGQVTVTMESS---------IPQASAIPVATISGQQGHPSNLHHIMTTN 208
            P +  S PP      T T  SS         +P  ++ P  T +       +    ++  
Sbjct: 1622 PTNIQSTPPM---DNTTTGSSSSGVTLGIAHLPIGTSSPAETSTNMALERRSSTATVSMA 1678

Query: 209  VQMSIIRSNAPGPPLHIG---ASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAV 265
              M ++ ++APG  +       S +   +    V  SSK ++  R  +Q   A ++    
Sbjct: 1679 GTMGLLVTSAPGRSISQSLGRVSSVLSESTTEGVTDSSKGSSP-RLNTQGNTALSSSLEP 1737

Query: 266  QHIIHQPIQSRPPVTTSNAIPPAV-----------VATV---------SATRAQSPVITT 305
             +     + +  P+T+S   P              V TV         + T + S  + +
Sbjct: 1738 SYAEGSQMSTSIPLTSSPTTPDVEFIGGSTFWTKEVTTVMTSDISKSSARTESSSATLMS 1797

Query: 306  TAAHATDSA-----------LSRPTLSIQHPPSAAISIQRP---AQSRDVTTRITLPSHP 351
            TA  +T++            L  PT S++  P  ++++        S D++  +   S  
Sbjct: 1798 TALGSTENTGKEKLRTASMDLPSPTPSMEVTPWISLTLSNAPNTTDSLDLSHGVHTSSAG 1857

Query: 352  ALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVS-------HTQAP 404
             L T +     + + +    G+  ++ +++   +T+T  + T    VS        T AP
Sbjct: 1858 TLATDRSLNTGVTRASRLENGSDTSSKSLSMGNSTHTSMTYTEKSEVSSSIHPRPETSAP 1917

Query: 405  TSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRA 464
             +     + P + + +  +  S+IPV +V+   IT + P I    P   S + P +    
Sbjct: 1918 GAETTLTSTPGNRAISLTLPFSSIPVEEVISTGIT-SGPDIN-SAPMTHSPITPPTIVWT 1975

Query: 465  SPNPVAMETR-----SDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQY-P 518
            S   +   T+     S  + SV  Q   ++ +   SA P   ++   ++S  ST   Y  
Sbjct: 1976 STGTIEQSTQPLHAVSSEKVSVQTQSTPYVNSVAVSASPTHENS---VSSGSSTSSPYSS 2032

Query: 519  VSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGT 578
             S ++ +S I+ +    + S +      L T                 ST   +    G 
Sbjct: 2033 ASLESLDSTISRRN--AITSWLWDLTTSLPTTTWP-------------STSLSEALSSGH 2077

Query: 579  PGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVA---NPIS 635
             G+      T      +  +T   +     T+   P+   ++ +  D +++      P+ 
Sbjct: 2078 SGVSNPSSTTTEFPLFSAASTSAAKQRNPETETHGPQNTAASTLNTDASSVTGLSETPVG 2137

Query: 636  NPFSAAPAATTVVQTHSQ-----SASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSM 690
               S+       + + S      S ST  P+ G++   S    K     + P SE  VS 
Sbjct: 2138 ASISSEVPLPMAITSRSDVSGLTSESTANPSLGTA---SSAGTKLTRTISLPTSESLVSF 2194

Query: 691  ---ATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGA 747
                 P TVS+   S+   +  T ++P  +  PP            PS  A ++ T+  +
Sbjct: 2195 RMNKDPWTVSIPLGSHPTTNTET-SIPVNSAGPPGLSTVASDVIDTPSDGAESIPTVSFS 2253

Query: 748  VPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNT 807
                  +TTI+  P  +     ++SS+      E+  +    P D M    +  P     
Sbjct: 2254 PSPDTEVTTISHFPEKTTHSFRTISSL----THELTSRVTPIPGDWMSSAMSTKPTG--- 2306

Query: 808  VSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLL 867
             SPS+ L         +   P  SP         ++ T       T S D+E +   S +
Sbjct: 2307 ASPSITL---GERRTITSAAPTTSP---------IVLTASFTETSTVSLDNETTVKTSDI 2354

Query: 868  VKAEKRKSPPKE 879
            + A K    P +
Sbjct: 2355 LDARKTNELPSD 2366



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 152/790 (19%), Positives = 292/790 (36%), Gaps = 89/790 (11%)

Query: 102  PQVQMLSTHHAVASATPVAVTAPPAHLTPAVP------LSFSEGLMKPPPKPTMPSRPIA 155
            P+++  S    + S+T  + T P   LT A        ++ S     P P  +  S  I+
Sbjct: 4895 PKLRETSISQEITSSTETS-TVPYKELTGATTEVSRTDVTSSSSTSFPGPDQSTVSLDIS 4953

Query: 156  PAPPSTLSLPPKVP--GQVTVTMESSIPQASAIPVATISGQQGHP-SNLHHIMT---TNV 209
                + LS  P +    ++T+T ++    A++    T+      P + +H  MT   + +
Sbjct: 4954 TETNTRLSTSPIMTESAEITITTQTGPHGATSQDTFTMDPSNTTPQAGIHSAMTHGFSQL 5013

Query: 210  QMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHI- 268
             ++ + S  P          + + ++ ++ +SS  +TT    +S LP    + P    + 
Sbjct: 5014 DVTTLMSRIPQDVSWTSPPSVDKTSSPSSFLSSPAMTTPSLISSTLPEDKLSSPMTSLLT 5073

Query: 269  -----IHQPIQSR-PPVTTS----NAIPPAVVATVSATRAQSPVITTTAAHATDSALSRP 318
                 I   +++R  PVT+S    ++    ++AT   ++    +  +     T+   +  
Sbjct: 5074 SGLVKITDILRTRLEPVTSSLPNFSSTSDKILATSKDSKDTKEIFPSINTEETNVKANNS 5133

Query: 319  TLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAA 378
                  P  A     +      +TT +  P+ P+   P   +H  ++ T           
Sbjct: 5134 GHESHSPALADSETPKATTQMVITTTVGDPA-PSTSMP---VHGSSETTNIKREPTYFLT 5189

Query: 379  TVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQI 438
                  +T+   S  T  S   ++ PT TI  ++    +S ++ ++T +   + V P   
Sbjct: 5190 PRLRETSTSQESSFPTDTSFLLSKVPTGTITEVSSTGVNS-SSKISTPDHDKSTVPPDTF 5248

Query: 439  THTSPRIQPDYPAERSSLIPISGHRASPNPVAMET----------RSDNRPSVPVQFQYF 488
            T   PR+       +S+ + I+   + P   +  T          +     +V   F Y 
Sbjct: 5249 TGEIPRVFTSSIKTKSAEMTITTQASPPESASHSTLPLDTSTTLSQGGTHSTVTQGFPYS 5308

Query: 489  LPTYPPSAYP--LAAHTYTPI--TSSVSTIRQYP-VSAQAPNSAITAQTGVGVASTVHLN 543
              T      P  ++  T  P+  TSSVS++   P +++ +P S+ + Q+       V   
Sbjct: 5309 EVTTLMGMGPGNVSWMTTPPVEETSSVSSLMSSPAMTSPSPVSSTSPQSIPSSPLPVTAL 5368

Query: 544  PMQLM--TVDASHARHIQGIQPAPISTQGI---QPAPIGTPGIQPAPLGTQGIHSATPIN 598
            P  ++  T D       + +  +P +   I   +PA         A +      + T + 
Sbjct: 5369 PTSVLVTTTDVLGTTSPESVTSSPPNLSSITHERPATYKDTAHTEAAMHHSTNTAVTNVG 5428

Query: 599  TQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTN 658
            T G               K+ + VLAD  T  A P+ +  S     +    T + S +  
Sbjct: 5429 TSG------------SGHKSQSSVLADSETSKATPLMSTTSTLGDTSVSTSTPNISQTNQ 5476

Query: 659  APAQGSSPRPSILRKKPATDGAKPKSEIH----------VSMATPVTVSMETVSNQNNDQ 708
               + ++     LR+   ++     +E +          ++ A+   +S    S  + D+
Sbjct: 5477 IQTEPTASLSPRLRESSTSEKTSSTTETNTAFSYVPTGAITQASRTEISSSRTSISDLDR 5536

Query: 709  PTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVP--ITPPITTIAAAPPPSVT 766
            PTIA P  +      + T               +T PGA    I P  T+       ++ 
Sbjct: 5537 PTIA-PDISTGMITRLFTSPIMTKSAEMTVTTQTTTPGATSQGILPWDTS------TTLF 5589

Query: 767  VGGSLSSV-LGPPVPEIKVKEEVEPMDI----MRPV----SAVPPLATNTVSPSLALLAN 817
             GG+ S+V  G P  EI       P D+      PV    S    ++ +  SPS     +
Sbjct: 5590 QGGTHSTVSQGFPHSEITTLRSRTPGDVSWMTTPPVEETSSGFSLMSPSMTSPSPVSSTS 5649

Query: 818  NLSMPTSDLP 827
              S+P+S LP
Sbjct: 5650 PESIPSSPLP 5659



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 162/742 (21%), Positives = 249/742 (33%), Gaps = 106/742 (14%)

Query: 38   PSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVV 97
            PST  S A S   +S +   +     V    G  S +     ++SS+ L S       + 
Sbjct: 3580 PSTWSSTAAS---DSWTVTDMTSNLKVARSPGTISTMHTTSFLASSTELDSMSTPHGRIT 3636

Query: 98   VRPYPQVQMLSTHHAVASATPVAV-TAPPAHLTPAVPLS-FSEGLMKPPPKPTMPSRPIA 155
            V     V   S   AV + T  +  T  P+  T + P+S FS         P + S    
Sbjct: 3637 VIGTSLVTPSSDASAVKTETSTSERTLSPSDTTASTPISTFSRVQRMSISVPDILSTSWT 3696

Query: 156  PAPPSTLSLP--------------PKVPGQVTV-----TMESSIPQASAIPVATISGQQG 196
            P+      +P              P  P    +     T++    ++ +   AT S  QG
Sbjct: 3697 PSSTEAEDVPVSMVSTDHASTKTDPNTPLSTFLFDSLSTLDWDTGRSLSSATATTSAPQG 3756

Query: 197  HPSNLHHIMTTNVQMSIIRSNAPGP---PLHIGASHLPRGAAAAAVMSSSKVT-TVLRPT 252
                     TT  ++++    +P     P  IG  H+      AA+  SS VT +   PT
Sbjct: 3757 --------ATTPQELTLETMISPATSQLPFSIG--HITSAVTPAAMARSSGVTFSRPDPT 3806

Query: 253  SQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATD 312
            S+     + Q       H     R   TT + IP       +  + Q     TT A AT 
Sbjct: 3807 SKKAEQTSTQLPTTTSAHPGQVPRSAATTLDVIPHTAKTPDATFQRQGQTALTTEARATS 3866

Query: 313  SALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSH--PALGTPKQQLHTMA------ 364
             + +    S   P +  I+    + S D    +T  S     L T    L +        
Sbjct: 3867 DSWNEKEKST--PSAPWITEMMNSVSEDTIKEVTSSSSVLRTLNTLDINLESGTTSSPSW 3924

Query: 365  QKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVT 424
            + + +    P  + T    +  +T    TT    S   A  STI     P+HS  A++  
Sbjct: 3925 KSSPYERIAPSESTTDKEAIHPSTNTVETTGWVTSSEHASHSTI-----PAHS--ASSKL 3977

Query: 425  TSNIPVAKVVPQQITHTSPRIQPDYP---AERSSLIPISGHRASPNPVAMETRSDNRPSV 481
            TS +       Q I   S    P+      E +S + I     SP    M+T S  + S+
Sbjct: 3978 TSPVVTTSTREQAIVSMSTTTWPESTRARTEPNSFLTIELRDVSP---YMDTSSTTQTSI 4034

Query: 482  PVQFQYFLPTYPPSAYPLAAHTYTPITS----SVSTIRQYPVSAQAPNSAITAQTGVGVA 537
                        P +  +     T ITS    S S + Q   S+ +P+ AIT        
Sbjct: 4035 ---------ISSPGSTAITKGPRTEITSSKRISSSFLAQSMRSSDSPSEAIT-------- 4077

Query: 538  STVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPI 597
                L+    MT        +Q   P   S          T      PL T    + +  
Sbjct: 4078 ---RLSNFPAMTESGGMILAMQTSPPGATSLSAPTLDTSATASWTGTPLATTQRFTYSE- 4133

Query: 598  NTQGLQPAPMGTQQPQP-----EGKTSAVVLADGATIVANPISNPFSAAPAATTVV---- 648
             T      P  T QP P        +S++V     T  +N +      +P++T  V    
Sbjct: 4134 KTTLFSKGPEDTSQPSPPSVEETSSSSSLVPIHATTSPSNILLTSQGHSPSSTPPVTSVF 4193

Query: 649  --QTHSQSASTNAPAQGSSPRPSILRKKPATDG--------AKPKSEIHVSMATPVTVSM 698
              +T     +T+       P  S+     +T G        ++    IH S  T VT +M
Sbjct: 4194 LSETSGLGKTTDMSRISLEPGTSLPPNLSSTAGEALSTYEASRDTKAIHHSADTAVT-NM 4252

Query: 699  ETVSNQNNDQPTIAVPPTAQQP 720
            E  S++ +  P    P  A  P
Sbjct: 4253 EATSSEYSPIPGHTKPSKATSP 4274



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 182/907 (20%), Positives = 315/907 (34%), Gaps = 171/907 (18%)

Query: 38   PSTGLSQAPSQIANSGSAGLINPAATVNDE--SGRDSEVSAREHMSSSSSLQSREEKQ-- 93
            P++ L+    + + S    L   A TV  +  +G  +EVS  E +S S +  S  E+   
Sbjct: 7536 PASSLTTRLRETSTSEETSLATEANTVLSKVSTGATTEVSRTEAISFSRTSMSGPEQSTM 7595

Query: 94   -EPVVVRPYPQVQMLSTHHAVASATPVAVTAPPA-------HLTPAVPLSFSEG---LMK 142
             + + +   P++   S     A  T    T P         +L  A   S+ E    +++
Sbjct: 7596 SQDISIGTIPRISASSVLTESAKMTITTQTGPSESTLESTLNLNTATTPSWVETHSIVIQ 7655

Query: 143  PPPKPTM-------------PSRPIAP--APPST-LSLPPKV-PGQVTVTMESSIPQASA 185
              P P M             PS P     +PPS+ LSLP    P  V+ T  + IP  S 
Sbjct: 7656 GFPHPEMTTSMGRGPGGVSWPSPPFVKETSPPSSPLSLPAVTSPHPVSTTFLAHIPP-SP 7714

Query: 186  IPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKV 245
            +PV ++      P+    I+ T+ +     S++     H   +     A   AV  S+  
Sbjct: 7715 LPVTSLL--TSGPATTTDILGTSTEPGTSSSSSLSTTSHERLTTYKDTAHTEAVHPSTNT 7772

Query: 246  TTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSA----TRAQSP 301
                       N AT     +        S P  TTS     +V+ +  A     R Q+ 
Sbjct: 7773 GGT--------NVATTSSGYKSQSSVLADSSPMCTTSTMGDTSVLTSTPAFLETRRIQTE 7824

Query: 302  VITT--------TAAHATDSALSRPTLSIQHPPSAAISIQR--------PAQSR---DVT 342
            + ++        + +  T S     T+  + P  A   I +        PAQS    D++
Sbjct: 7825 LASSLTPGLRESSGSEGTSSGTKMSTVLSKVPTGATTEISKEDVTSIPGPAQSTISPDIS 7884

Query: 343  TR-ITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATN-TIPSATTAGSVSH 400
            TR ++  S   + T   ++ TM   T     T    +T+     T+ T+  +T +   SH
Sbjct: 7885 TRTVSWFSTSPVMTESAEI-TMNTHTSPLGATTQGTSTLDTSSTTSLTMTHSTISQGFSH 7943

Query: 401  TQAPT-------------STIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQP 447
            +Q  T               ++  T PS S  ++  TTS  PV+  +P+ I+        
Sbjct: 7944 SQMSTLMRRGPEDVSWMSPPLLEKTRPSFSLMSSPATTSPSPVSSTLPESIS-------- 7995

Query: 448  DYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPI 507
                  SS +P++    S   +A  T   ++ S PV         P +    +       
Sbjct: 7996 ------SSPLPVTSLLTS--GLAKTTDMLHKSSEPV------TNSPANLSSTSVEILATS 8041

Query: 508  TSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPIS 567
              +  T + +P       S+    T VG +S+ H      +  D+  ++    +    + 
Sbjct: 8042 EVTTDTEKTHP-------SSNRTVTDVGTSSSGH-ESTSFVLADSQTSK----VTSPMVI 8089

Query: 568  TQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGA 627
            T  ++   + T         T G    + I T+      +G +      KTS    +   
Sbjct: 8090 TSTMEDTSVST--------STPGFFETSRIQTEPTSSLTLGLR------KTS----SSEG 8131

Query: 628  TIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIH 687
            T +A  +S   S  P   T   + ++  S+                          S   
Sbjct: 8132 TSLATEMSTVLSGVPTGATAEVSRTEVTSS--------------------------SRTS 8165

Query: 688  VSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGA 747
            +S    +TVS ET +      PT ++   + +      T    ++P S   V +ST P  
Sbjct: 8166 ISGFAQLTVSPETSTETITRLPTSSIMTESAEMMIKTQTDPPGSTPESTHTVDISTTPNW 8225

Query: 748  VPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNT 807
            V     +T   +    +  V  S   +L P    ++       +  +   ++  P+++  
Sbjct: 8226 VETHSTVTQRFSHSEMTTLVSRSPGDMLWPSQSSVEETSSASSLLSLPATTSPSPVSSTL 8285

Query: 808  VS--PSLALLANNLSMP----TSD-----LPPGASPRKKPRKQQHVISTEEGDMMETNST 856
            V   PS +L   +L  P    T+D       PG S         H   T   D ++T   
Sbjct: 8286 VEDFPSASLPVTSLLNPGLVITTDRMGISREPGTSSTSNLSSTSHERLTTLEDTVDTEDM 8345

Query: 857  DDEKSTA 863
                 TA
Sbjct: 8346 QPSTHTA 8352



 Score = 38.5 bits (88), Expect = 0.033
 Identities = 159/748 (21%), Positives = 267/748 (35%), Gaps = 119/748 (15%)

Query: 147  PTMPSRPIAPAPPSTLSLP-PKVPGQVTVTMESSIPQASAIPVATISGQQ--GHPSNLHH 203
            PT  S   A + PS  S   P+VP   T T  ++ P  S+   +   G    G PS L  
Sbjct: 2393 PTSISGMTASSSPSLFSSDRPQVPTSTTETNTATSPSVSSNTYSLDGGSNVGGTPSTLPP 2452

Query: 204  IMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAA--VMSSSKVTTVLRP--------TS 253
               T+   +     A   P+   ++ +    A+      S+S VT+V  P        T+
Sbjct: 2453 FTITHPVETSSALLAWSRPVRTFSTMVSTDTASGENPTSSNSVVTSVPAPGTWTSVGSTT 2512

Query: 254  QLPNAATAQPAVQHIIHQPIQSR-PPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATD 312
             LP     + +     H  + S   P T       A V T S+  +++ ++TT+ + A  
Sbjct: 2513 DLPAMGFLKTSPAGEAHSLLASTIEPATAFTPHLSAAVVTGSSATSEASLLTTSESKAIH 2572

Query: 313  SALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTG 372
            S+   PT     P S A                   +     TP+  L  +  +T  +T 
Sbjct: 2573 SSPQTPTT----PTSGA-------------------NWETSATPESLL--VVTETSDTTL 2607

Query: 373  TPVAAATVAPILATNTIPSA--TTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPV 430
            T     T   + +T + P +   + G++S    PT    T  +P  ++  T+   ++   
Sbjct: 2608 TSKILVTDTILFSTVSTPPSKFPSTGTLSGASFPTLLPDTPAIPLTATEPTSSLATSFDS 2667

Query: 431  AKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVP---VQFQY 487
              +V   I   S    P+     S         ++ + + ++T S+   S+P   +Q   
Sbjct: 2668 TPLV--TIASDSLGTVPETTLTMS-------ETSNGDALVLKTVSNPDRSIPGITIQGVT 2718

Query: 488  FLPTYPPSAYP--LAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPM 545
              P +P S  P  + A   T    S+ T+    + A    S + +Q+     +T      
Sbjct: 2719 ESPLHPSSTSPSKIVAPRNTTYEGSI-TVALSTLPAGTTGSLVFSQSSENSETTA----- 2772

Query: 546  QLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPA 605
                VD+S       + P    +QG+      + GI+     + G        T+     
Sbjct: 2773 ---LVDSSAGLERASVMPLTTGSQGM----ASSGGIRSGSTHSTG--------TKTFSSL 2817

Query: 606  PMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSS 665
            P+ T  P   G+ +A+     + I  N ++   S AP    V  T ++S      +  SS
Sbjct: 2818 PL-TMNP---GEVTAM-----SEITTNRLTATQSTAPKGIPVKPTSAESGLLTPVSASSS 2868

Query: 666  PRPSI--LRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPT 723
            P  +   L   P T G  P+S +    +     S++T S         A  PT  Q   T
Sbjct: 2869 PSKAFASLTTAPPTWGI-PQSTLTFEFSE--VPSLDTKS---------ASLPTPGQSLNT 2916

Query: 724  IPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSV-------TVGGSLSSVLG 776
            IP      S  S  + +LS  P   P    +T+  A    S        T  GS S  + 
Sbjct: 2917 IPD-----SDASTASSSLSKSPEKNPRARMMTSTKAISASSFQSTGFTETPEGSASPSMA 2971

Query: 777  PPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKP 836
               P +      +P      +S   P   ++   S +L     S  T+    G + R   
Sbjct: 2972 GHEPRVPTSGTGDPRYASESMSYPDPSKASSAMTSTSL----ASKLTTLFSTGQAARSGS 3027

Query: 837  RKQQHVISTEEGDMMETNSTDDEKSTAK 864
                  +STE+    ET+      ST++
Sbjct: 3028 SSSPISLSTEK----ETSFLSPTASTSR 3051



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 143/753 (18%), Positives = 266/753 (35%), Gaps = 108/753 (14%)

Query: 38   PSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSR---EEKQE 94
            P   +SQA   +  S +A      + V        E +     +   S QS    EE   
Sbjct: 5867 PIGTISQATLTLDTSSTASWEGTHSPVTQRFPHSEETTTMSRSTKGVSWQSPPSVEETSS 5926

Query: 95   PVVVRPYPQVQMLST-HHAVASATPVAVTAPPAHLTPAVPLS--FSEGLMKPPPKPTMPS 151
            P    P P +   S+ + AV+ ++P          T A+P++   + G  K        S
Sbjct: 5927 PSSPVPLPAITSHSSLYSAVSGSSP----------TSALPVTSLLTSGRRKTIDMLDTHS 5976

Query: 152  RPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQM 211
              +  + PS  S   ++      T   +I   S     T  G       LH  ++ + Q 
Sbjct: 5977 ELVTSSLPSASSFSGEILTSEASTNTETI-HFSENTAETNMGTTNSMHKLHSSVSIHSQP 6035

Query: 212  S---------------IIRSNAPGPPLHIGASH---------LPRGAAAAAVMSSSKVTT 247
            S               I+ ++ PG P                L   + A  + S+++  T
Sbjct: 6036 SGHTPPKVTGSMMEDAIVSTSTPGSPETKNVDRDSTSPLTPELKEDSTALVMNSTTESNT 6095

Query: 248  VLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTA 307
            V    S   +AAT     +   + P  +  P +  +   P +    S++ + SP +T + 
Sbjct: 6096 VFSSVSL--DAATEVSRAEVTYYDP--TFMPASAQSTKSPDISPEASSSHSNSPPLTIS- 6150

Query: 308  AHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTP----------- 356
                    +  T++ Q  PS   S+ +   + D +T  T    P+  T            
Sbjct: 6151 --------THKTIATQTGPSGVTSLGQ--LTLDTSTIATSAGTPSARTQDFVDSETTSVM 6200

Query: 357  KQQLHTMAQKTIFSTGTPVAAATVAPILAT-------NTIPSATTAGSVSHTQAPTSTIV 409
               L+ + + + FS     + ++ AP+L T       +T+   +T+  VS T  PT T+ 
Sbjct: 6201 NNDLNDVLKTSPFSAEEANSLSSQAPLLVTTSPSPVTSTLQEHSTSSLVSVTSVPTPTLA 6260

Query: 410  TMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPV 469
             +T    +      +  N+       +  T T       +P+  +++  + G  +SPN  
Sbjct: 6261 KITDMDTNLEPVTRSPQNLRNTLATSEATTDTHTM----HPSINTAVANV-GTTSSPNEF 6315

Query: 470  AMETRSDNRP--------SVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSA 521
                  D+ P                 + T  P +  +         S +  +R+   S 
Sbjct: 6316 YFTVSPDSDPYKATSAVVITSTSGDSIVSTSMPRSSAMKKIESETTFSLIFRLRETSTSQ 6375

Query: 522  QAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPI----STQGIQPAP-- 575
            +  +S+ T+ T    A T     +    + +S    IQG +   +    ST+ +      
Sbjct: 6376 KIGSSSDTS-TVFDKAFTAATTEVSRTELTSSSRTSIQGTEKPTMSPDTSTRSVTMLSTF 6434

Query: 576  IGTPGIQPAPLGTQ-GIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPI 634
             G    +   + TQ G H AT   T     +   +Q       T      D +T+ +   
Sbjct: 6435 AGLTKSEERTIATQTGPHRATSQGTLTWDTSITTSQAGTHSAMTHGFSQLDLSTLTSR-- 6492

Query: 635  SNPFSAAPAATTVVQTHSQSASTNAPAQGS-SPRPSILRKKPATDGAKPKSEIHVSMATP 693
               + +  +  +V +T S S+  + PA  S SP P+ L +      ++P S +H++ + P
Sbjct: 6493 VPEYISGTSPPSVEKTSSSSSLLSLPAITSPSPVPTTLPE------SRPSSPVHLT-SLP 6545

Query: 694  VTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPT 726
             +  ++T     +     ++PP        IPT
Sbjct: 6546 TSGLVKTTDMLAS---VASLPPNLGSTSHKIPT 6575



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 160/862 (18%), Positives = 297/862 (34%), Gaps = 146/862 (16%)

Query: 39   STGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVV 98
            S GL +A      +GS G+   A++    SG            S+ S  ++     P+ +
Sbjct: 2777 SAGLERASVMPLTTGSQGM---ASSGGIRSG------------STHSTGTKTFSSLPLTM 2821

Query: 99   RPYPQVQM--LSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIA- 155
             P     M  ++T+   A+ +    TAP     P  P S   GL+ P    + PS+  A 
Sbjct: 2822 NPGEVTAMSEITTNRLTATQS----TAPKG--IPVKPTSAESGLLTPVSASSSPSKAFAS 2875

Query: 156  --PAPP------STLSLP-PKVPGQVTVTME--------SSIPQASAIPVATISGQQGHP 198
               APP      STL+    +VP   T +          ++IP + A   ++   +    
Sbjct: 2876 LTTAPPTWGIPQSTLTFEFSEVPSLDTKSASLPTPGQSLNTIPDSDASTASSSLSKSPEK 2935

Query: 199  SNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNA 258
            +    +MT+   +S     +       G +  P G+A+ ++              ++P +
Sbjct: 2936 NPRARMMTSTKAISASSFQS------TGFTETPEGSASPSMAGHE---------PRVPTS 2980

Query: 259  ATAQP--AVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRA------QSPVITTTAAHA 310
             T  P  A + + +          TS ++   +    S  +A       SP+  +T    
Sbjct: 2981 GTGDPRYASESMSYPDPSKASSAMTSTSLASKLTTLFSTGQAARSGSSSSPISLSTEKET 3040

Query: 311  T----DSALSRPTL-----SIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLH 361
            +     ++ SR T      S+   P+  + +Q  A +   T+ + +           Q  
Sbjct: 3041 SFLSPTASTSRKTSLFLGPSMARQPNILVHLQTSALTLSPTSTLNMSQEEPPELTSSQTI 3100

Query: 362  TMAQKTIFSTGTPVAAATVAPILATNTIP-SATTAGSVSHTQAPTSTIVTMTVPSHSSHA 420
               + T   T T     +  P   T+ +P S+ T  +     +P +   +++VP+ +S  
Sbjct: 3101 AEEEGTTAETQTLTFTPSETP---TSLLPVSSPTEPTARRKSSPETWASSISVPAKTSLV 3157

Query: 421  TAVTTSNIPVAKVVPQ--QITHTSPRIQPDYPAERSSLIPISGHRASPN-PVAMETRSDN 477
                 + +   K+  Q  Q   T P      PAE +   P      SP     ++  S  
Sbjct: 3158 ETTDGTLVTTIKMSSQAAQGNSTWPA-----PAEETGSSPAGTSPGSPEMSTTLKIMSSK 3212

Query: 478  RPSVPVQFQYFLPTYP---PSAYPLAAHTYTPIT-------SSVSTIRQYPVSAQAPNSA 527
             PS+  + +  +   P   P        T  P+T       S  ++I   P    +P  +
Sbjct: 3213 EPSISPEIRSTVRNSPWKTPETTVPMETTVEPVTLQSTALGSGSTSISHLPTGTTSPTKS 3272

Query: 528  ITAQ---------------------TGVGVASTVHLNPMQLMTVDASHARHIQGI--QPA 564
             T                       +G    +   L  M  +++++  AR I G   Q +
Sbjct: 3273 PTENMLATERVSLSPSPPEAWTNLYSGTPGGTRQSLATMSSVSLESPTARSITGTGQQSS 3332

Query: 565  P---ISTQGIQ-----PAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEG 616
            P     T G++      +  GT G     L T       P+ +    P  + +   + + 
Sbjct: 3333 PELVSKTTGMEFSMWHGSTGGTTGDTHVSLSTSSNILEDPVTS----PNSVSSLTDKSKH 3388

Query: 617  KTSAVVLADGATIVANPISNPFSAAPAAT--TVVQTHSQSASTNAPAQGS----SPRPSI 670
            KT   V      I +  ++N   AA   T  +V + +S ++S +    GS       P +
Sbjct: 3389 KTETWV--STTAIPSTVLNNKIMAAEQQTSRSVDEAYSSTSSWSDQTSGSDITLGASPDV 3446

Query: 671  LRKKPATDGAKPKSEIHVSMATPVTVSMETVS-NQNNDQPTIAVPPTAQQPPPTIPTMIA 729
                  T  A+  S + +        S+   S  + +   ++  P    +      + + 
Sbjct: 3447 TNTLYITSTAQTTSLVSLPSGDQGITSLTNPSGGKTSSASSVTSPSIGLETLRANVSAVK 3506

Query: 730  AASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVE 789
            +   P+   ++ ++ P  V I    T        ++T  G+ S     P PE+       
Sbjct: 3507 SDIAPTAGHLSQTSSPAEVSILDVTTAPTPGISTTITTMGTNSISTTTPNPEV------- 3559

Query: 790  PMDIMRPVSAVPPLATNTVSPS 811
             M  M    A     T+T  PS
Sbjct: 3560 GMSTMDSTPATERRTTSTEHPS 3581


>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
          Length = 2089

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 212/987 (21%), Positives = 330/987 (33%), Gaps = 171/987 (17%)

Query: 5    RHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINPAATV 64
            R  Q GE E     GG + Q   +S   P  G  +  L    S    SGS          
Sbjct: 944  RDTQRGEPE-----GGSQDQKGQASSPTPEPGVGAGDLPGPTSAPVPSGS---------- 988

Query: 65   NDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAP 124
                GR S VS R H     + +     ++   +R   +V         A   P   T P
Sbjct: 989  -QSGGRGSPVSPRRHQKGLLNCKM-PPAEKASRIRAAEKVSRGDQESPDACLPP---TVP 1043

Query: 125  PAHLTPAVPL-SFSEGLMKPPP--KPTMPS-RPI-----------APAPPSTLSLPPKVP 169
             A   P  PL S S+  + PPP   P +PS +P            AP  P +  L P  P
Sbjct: 1044 EAPAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHP 1103

Query: 170  GQVTVTMESS----IPQASAIPV---ATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPP 222
                 T +SS     P  SA P    +T + Q   P        +    S +++  P  P
Sbjct: 1104 KPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVP 1163

Query: 223  LHIGASHLPRGAAAAAVMSSSKVTTVLR----------PTSQLPNAATAQPAVQHIIHQP 272
                A  L    +    ++S   + V R          P + +P A   QP+      +P
Sbjct: 1164 T---APELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTALELQPSTS--TDRP 1218

Query: 273  IQSRPP------------VTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTL 320
            + S P             V T   + P       +T    PV +     AT    +R ++
Sbjct: 1219 VTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNRSSV 1278

Query: 321  SIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKT-IFSTGTPVAAAT 379
                P        RP+ S D              TPK    T   +T + S  TP     
Sbjct: 1279 KTPEPVVPTAPELRPSTSTDRPV-----------TPKPTSRTTRSRTNMSSVKTPETVVP 1327

Query: 380  VAPILATNTI--------PSATTAGS---VSHTQAPTSTI-VTMTVPSHSSHATAVTTSN 427
             AP L  +T         P++ T  S   +S  + P ST+ +   +P  +S    VT   
Sbjct: 1328 TAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPE- 1386

Query: 428  IPVAKV-----------VPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRS- 475
             P ++             P+ +  T+P+++P    ++           +P P +  TR  
Sbjct: 1387 -PTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQP---------VTPEPTSQATRGR 1436

Query: 476  DNRPSVPVQFQYFLPTYP---PSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITA-- 530
             NR SV    +  +PT P   PS       T  P TS  +  R    S + P + +    
Sbjct: 1437 TNRSSVKTP-ETVVPTAPELQPSTSTDQPVTPEP-TSQATRGRTDRSSVKTPETVVPTAP 1494

Query: 531  --QTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPL-- 586
              Q        V   P    T    +   ++  +    +   +QP+      + P P   
Sbjct: 1495 ELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSR 1554

Query: 587  GTQGIHSATPINT--------QGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPIS-NP 637
             T+G  + + + T          LQP+    Q   PE  + A       + V  P    P
Sbjct: 1555 ATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVVP 1614

Query: 638  FSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVS 697
             +  P  TT          T+   +  + R S+   KP    A   S++     T  +V+
Sbjct: 1615 TAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAA---SDLEPFTPTDQSVT 1671

Query: 698  METVSNQNNDQ---------------PTIAVPPTAQQP----PPTIPTMI---AAASPPS 735
             E ++     +               P    P T  QP    P T P+ I    AA  P 
Sbjct: 1672 PEAIAQGGQSKTLRSSTVRAMPVPTTPEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPG 1731

Query: 736  QPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMR 795
              A  +   P + P+ P           +V    SL+++  P  P++     +E      
Sbjct: 1732 SLAAPIDHKPCSAPLEPKSQASRNQRWGAVRAAESLTAIPEPASPQL-----LETPIHAS 1786

Query: 796  PVSAVPPLATNTVSPSL---ALLANNLSMPTSDLPPGASPRKKPRKQQH--VISTEEGDM 850
             +  V P   +  +P L   A  +   S+ T D PP     ++    Q   +I  EE D 
Sbjct: 1787 QIQKVEPAGRSRFTPELQPKASQSRKRSLATMDSPPHQKQPQRGEVSQKTVIIKEEEEDT 1846

Query: 851  METNSTDDEKSTAKSLLVKAEKRKSPP 877
             E    +++  T K    K ++ +  P
Sbjct: 1847 AEKPGKEEDVVTPKPGKRKRDQAEEEP 1873


>gi|161019170 mucin 5AC [Homo sapiens]
          Length = 6207

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 156/721 (21%), Positives = 249/721 (34%), Gaps = 118/721 (16%)

Query: 114  ASATPV---AVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPG 170
            A+A P      T P A    A+P S          + T P+  ++ A PS  S P  V  
Sbjct: 3157 ATALPALRSTATTPTATSFTAIPSSSLGTTWTRLSQTTTPTATMSTATPS--STPETVHT 3214

Query: 171  QVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGP----PLHIG 226
               +T  ++   A+   VAT S   G       + TT    +   S++PG     P+ I 
Sbjct: 3215 STVLTTTATTTGATG-SVATPSSTPGTAHTTKVLTTTTTGFTATPSSSPGTARTLPVWIS 3273

Query: 227  ASHLPRGAAAAAVMSS------------SKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQ 274
             +  P    +    SS            +  TTV   +   P+++T      H    P+ 
Sbjct: 3274 TTTTPTTRGSTVTPSSIPGTTHTPTVLTTTTTTVATGSMATPSSSTQTSGTTHT--PPVP 3331

Query: 275  SRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQR 334
            +    T   ++ P+   TV      +   T    H T+     P+    H P+A      
Sbjct: 3332 NTTATTHGRSLSPSSPHTVRTAWTSATSGTLGTTHITE-----PSTGTSHTPAA------ 3380

Query: 335  PAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATT 394
                   TT  T  S PAL +P     T        T TP      +   AT T PS T 
Sbjct: 3381 -------TTGTTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTRATSRTTATAT-PSKTR 3432

Query: 395  AGSV---SHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPD-YP 450
              ++   S T AP +T+VTM      + +               + + ++ P   P    
Sbjct: 3433 TSTLLPSSPTSAPITTVVTMGCEPQCAWS---------------EWLDYSYPMPGPSGGD 3477

Query: 451  AERSSLIPISGHRASPNPVAMETRSDNRPSVPVQ-------------------------- 484
             +  S I  +G      P+ +E R+  +P VP++                          
Sbjct: 3478 FDTYSNIRAAGGAVCEQPLGLECRAQAQPGVPLRELGQVVECSLDFGLVCRNREQVGKFK 3537

Query: 485  --FQYFLPTY------PPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGV 536
              F Y +  +       PS  P  + T TP ++  +T      +  A  +A T  T +  
Sbjct: 3538 MCFNYEIRVFCCNYGHCPST-PATSSTATPSSTPGTTWILTEQTTAATTTATTGSTAIPS 3596

Query: 537  ASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGT--------PGIQPAPLGT 588
            ++     P +++T  A+          +  S +     P+ T            P P  T
Sbjct: 3597 STPGTAPPPKVLTSTATTPTATSSKATSSSSPRTATTLPVLTSTATKSTATSFTPIPSFT 3656

Query: 589  QGIHSATPINTQGLQPAPMGTQQPQ--PEGKTSAVVLADGATIVANPISNPFSAAPAATT 646
             G     P  T     A M T  P   PE   ++ VL   AT      S    ++   TT
Sbjct: 3657 LGTTGTLPEQTT-TPMATMSTIHPSSTPETTHTSTVLTTKATTTRATSSMSTPSSTPGTT 3715

Query: 647  VVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNN 706
             + T   +A+T   A G +  PS     P T     +     ++  P T S  T S+   
Sbjct: 3716 WILTELTTAATTTAATGPTATPS---STPGTTWILTEPSTTATVTVP-TGSTATASSTRA 3771

Query: 707  DQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPG--AVPITPPITTIAAAPPPS 764
               T+ V  +      T PT+I++ + PS      + +P   +   TP  T++ A P  S
Sbjct: 3772 TAGTLKVLTST----ATTPTVISSRATPSSSPGTATALPALRSTATTPTATSVTAIPSSS 3827

Query: 765  V 765
            +
Sbjct: 3828 L 3828



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 154/673 (22%), Positives = 236/673 (35%), Gaps = 82/673 (12%)

Query: 115  SATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTV 174
            +++P    APPA  T AVP + SEGL  P    T+ +           S  P VPG  T 
Sbjct: 2327 TSSPGLTRAPPASTT-AVP-TLSEGLTSPRYTSTLGTATTGGPTTPAGSTEPTVPGVAT- 2383

Query: 175  TMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGA 234
               S++P  SA+P  T S     PS    +  T +  S  R           AS  P   
Sbjct: 2384 ---STLPTRSALPGTTGSLGTWRPSQPPTLAPTTMATSRARPTGTAST----ASKEPLTT 2436

Query: 235  AAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVT----------TSNA 284
            + A  + +S+++T    TS      T  P       Q      P             ++ 
Sbjct: 2437 SLAPTL-TSELSTSQAETSTPRTETTMSPLTNTTTSQGTTRCQPKCEWTEWFDVDFPTSG 2495

Query: 285  IPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPP---SAAISIQRPAQSRDV 341
            +    + T    RA    +          A + P +SI       + ++      ++ D 
Sbjct: 2496 VAGGDMETFENIRAAGGKMCWAPKSIECRAENYPEVSIDQVGQVLTCSLETGLTCKNEDQ 2555

Query: 342  TTRITL--PSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVS 399
            T R  +    +  +       H  +     ST TP +      IL T    +ATT  S  
Sbjct: 2556 TGRFNMCFNYNVRVLCCDDYSHCPSTPATSSTATPSSTPGTTWIL-TKPTTTATTTASTG 2614

Query: 400  HTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPI 459
             T  PTST+   T P      T  TT  +  +K  P     +SP      PA RS+    
Sbjct: 2615 STATPTSTL--RTAPPPKVLTTTATTPTVTSSKATPS----SSPGTATALPALRSTATTP 2668

Query: 460  SGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPV 519
            +    +P P +    +  R S        + T  PS+ P  AHT T +T++ +T      
Sbjct: 2669 TATSVTPIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETAHTSTVLTATATT------ 2722

Query: 520  SAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTP 579
               A  S  T  +  G A T  +                        +T G    P  +P
Sbjct: 2723 -TGATGSVATPSSTPGTAHTTKV---------------------PTTTTTGFTATPSSSP 2760

Query: 580  GIQPAPLGTQGIHSATPINTQGLQPAPM---GTQQPQPEGKTSAVVLADGATIVANPISN 636
            G    P     I + T   T+G    P    GT        T+   +A G+  +A P S+
Sbjct: 2761 GTALTP--PVWISTTTTPTTRGSTVTPSSIPGTTHTATVLTTTTTTVATGS--MATPSSS 2816

Query: 637  PFSAA-----PAATTVVQTHSQSASTNAP----AQGSSPRPSILRKKPATDGAKPKSEIH 687
              ++      P   T+  TH +S   ++P       +S    IL     T+ +   S  H
Sbjct: 2817 TQTSGTTHTPPVPNTMATTHGRSLPPSSPHTVRTAWTSATSGILGTTHITEPSTVTS--H 2874

Query: 688  VSMATPVTVSMET--VSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPA-VALSTI 744
               AT  T    T  +S+ +    T   PP+     P   T  +  +  + P+    ST+
Sbjct: 2875 TLAATTGTTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATATPSKTRTSTL 2934

Query: 745  PGAVPITPPITTI 757
              + P + PITT+
Sbjct: 2935 LPSSPTSAPITTV 2947



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 173/815 (21%), Positives = 273/815 (33%), Gaps = 146/815 (17%)

Query: 114  ASATPV---AVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPG 170
            A+A P      T P A    A+P S          + T P+  ++ A PS+    P+   
Sbjct: 4304 ATALPALRSTATTPTATSFTAIPSSSLGTTWTRLSQTTTPTATMSTATPSST---PETAH 4360

Query: 171  QVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPG----PPLHIG 226
              TV   ++    +   VAT S   G         TT    ++  S++PG    PP+ I 
Sbjct: 4361 TSTVLTTTATTTRATGSVATPSSTPGTAHTTKVPTTTTTGFTVTPSSSPGTARTPPVWIS 4420

Query: 227  ASHLPRGAAAAAVMSS------------SKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQ 274
             +  P  + +    SS            +  TTV   +   P+++T      H    P+ 
Sbjct: 4421 TTTTPTTSGSTVTPSSVPGTTHTPTVLTTTTTTVATGSMATPSSSTQTSGTTHT--PPVP 4478

Query: 275  SRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQR 334
            +    T   ++ P+   TV      +   T    H T+     P+    H P+A      
Sbjct: 4479 NTTATTHGRSLSPSSPHTVRTAWTSATSGTLGTTHITE-----PSTGTSHTPAA------ 4527

Query: 335  PAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATT 394
                   TT  T  S PAL +P                 P +  T +P     T P  TT
Sbjct: 4528 -------TTGTTQHSTPALSSPH----------------PSSRTTESPPSPGTTTPGHTT 4564

Query: 395  AGS-VSHTQAPTSTIVTMTVPSHSSHA--TAVTTSNIPVAKVVPQQITHTSPRIQPD-YP 450
            A S  + T  P+ T  +  +PS  + A  T V T+         + + ++ P   P    
Sbjct: 4565 ATSRTTATATPSKTRTSTLLPSSPTSAPITTVVTTGCEPQCAWSEWLDYSYPMPGPSGGD 4624

Query: 451  AERSSLIPISGHRASPNPVAMETRSDNRPSVPV--------------------------- 483
             +  S I  +G      P+ +E R+  +P VP+                           
Sbjct: 4625 FDTYSNIRAAGGAVCEQPLGLECRAQAQPGVPLGELGQVVECSLDFGLVCRNREQVGKFK 4684

Query: 484  -----QFQYFLPTYP--PSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGV 536
                 + + F   Y   PS  P  + T  P ++  +T     ++  A  +A T  T    
Sbjct: 4685 MCFNYEIRVFCCNYGHCPST-PATSSTAMPSSTPGTTWILTELTTTATTTASTGSTATPS 4743

Query: 537  ASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGT--------PGIQPAPLGT 588
            ++     P +++T  A+          +  S +     P+ T          + P P  T
Sbjct: 4744 STPGTAPPPKVLTSPATTPTATSSKATSSSSPRTATTLPVLTSTATKSTATSVTPIPSST 4803

Query: 589  QGIHSATPINTQGLQPAPMGTQQPQ--PEGKTSAVVLADGATIVANPISNPFSAAPAATT 646
             G     P  T     A M T  P   PE   ++ VL   AT      S    ++   TT
Sbjct: 4804 LGTTGTLPEQTT-TPVATMSTIHPSSTPETTHTSTVLTTKATTTRATSSTSTPSSTPGTT 4862

Query: 647  VVQTHSQSASTNAPAQGSSPRPS-------ILRKKPAT--------DGAKPKSE------ 685
             + T   +A+T   A G +  PS       IL +   T          A P S       
Sbjct: 4863 WILTELTTAATTTAATGPTATPSSTPGTTWILTELTTTATTTASTGSTATPSSTPGTTWI 4922

Query: 686  -IHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTI 744
                S    VTV   + +  ++ Q T   P  +     T PT+ ++ + PS      + +
Sbjct: 4923 LTEPSTTATVTVPTGSTATASSTQATAGTPHVS--TTATTPTVTSSKATPSSSPGTATAL 4980

Query: 745  PG--AVPITPPITTIAAAPPPSV-TVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVP 801
            P   +   TP  T+  A P  S+ T    LS    P             M    P S   
Sbjct: 4981 PALRSTATTPTATSFTAIPSSSLGTTWTRLSQTTTP----------TATMSTATPSSTPE 5030

Query: 802  PLATNTVSPSLALLANNL-SMPTSDLPPGASPRKK 835
             + T+TV  + A       S+ T    PG +   K
Sbjct: 5031 TVHTSTVLTATATTTGATGSVATPSSTPGTAHTTK 5065



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 157/762 (20%), Positives = 254/762 (33%), Gaps = 131/762 (17%)

Query: 95   PVVVRPYPQVQMLSTHHAVASATPVAVTAPPA-HLTPAVPLSFSEGLMKPPPKPTM---- 149
            P V+        +++  A  S++P   TA PA   T   P + S   + P P  ++    
Sbjct: 2629 PKVLTTTATTPTVTSSKATPSSSPGTATALPALRSTATTPTATS---VTPIPSSSLGTTW 2685

Query: 150  -----PSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHI 204
                  + P A    +T S  P+     TV   ++    +   VAT S   G        
Sbjct: 2686 TRLSQTTTPTATMSTATPSSTPETAHTSTVLTATATTTGATGSVATPSSTPGTAHTTKVP 2745

Query: 205  MTTNVQMSIIRSNAPG----PPLHIGASHLPR------------GAAAAAVMSSSKVTTV 248
             TT    +   S++PG    PP+ I  +  P             G    A + ++  TTV
Sbjct: 2746 TTTTTGFTATPSSSPGTALTPPVWISTTTTPTTRGSTVTPSSIPGTTHTATVLTTTTTTV 2805

Query: 249  LRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSA--TRAQSPVITTT 306
               +   P+++T      H    P+ +    T   ++PP+   TV    T A S ++ TT
Sbjct: 2806 ATGSMATPSSSTQTSGTTHT--PPVPNTMATTHGRSLPPSSPHTVRTAWTSATSGILGTT 2863

Query: 307  AAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQK 366
              H T+     P+    H  +A             TT  T  S PAL +P          
Sbjct: 2864 --HITE-----PSTVTSHTLAA-------------TTGTTQHSTPALSSPH--------- 2894

Query: 367  TIFSTGTPVAAATVAPILATNTIPSATTAGS-VSHTQAPTSTIVTMTVPSHSSHA--TAV 423
                   P +  T +P     T P  TTA S  + T  P+ T  +  +PS  + A  T V
Sbjct: 2895 -------PSSRTTESPPSPGTTTPGHTTATSRTTATATPSKTRTSTLLPSSPTSAPITTV 2947

Query: 424  TTSNIPVAKVVPQQITHTSPRIQPD-YPAERSSLIPISGHRASPNPVAMETRSDNRPSVP 482
             T          + + ++ P   P     +  S I  +G      P+ +E R+  +P VP
Sbjct: 2948 VTMGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSNIRAAGGAVCEQPLGLECRAQAQPGVP 3007

Query: 483  VQ----------------------------FQYFL----------PTYP-------PSAY 497
            ++                            F Y +          P+ P       PS+ 
Sbjct: 3008 LRELGQVVECSLDFGLVCRNREQVGKFKMCFNYEIRVFCCNYGHCPSTPATSSTAMPSST 3067

Query: 498  PLAAHTYTPITSSVSTIRQYPVSAQAPNSAITA--QTGVGVASTVHLNPMQLMTVDASHA 555
            P      T +T++ +T      +A   ++  T    T     +TV +      T  ++ A
Sbjct: 3068 PGTTWILTELTTTATTTESTGSTATPSSTPGTTWILTEPSTTATVTVPTGSTATASSTQA 3127

Query: 556  R----HIQGIQPAPISTQGIQPAPIGTPGIQPA-PLGTQGIHSATPINTQGLQPAPMGTQ 610
                 H+      P  T   +  P  +PG   A P       + T  +   +  + +GT 
Sbjct: 3128 TAGTPHVSTTATTPTVTSS-KATPFSSPGTATALPALRSTATTPTATSFTAIPSSSLGTT 3186

Query: 611  QPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSI 670
              +    T+       AT  + P +   S     T      + S +T +   G++    +
Sbjct: 3187 WTRLSQTTTPTATMSTATPSSTPETVHTSTVLTTTATTTGATGSVATPSSTPGTAHTTKV 3246

Query: 671  LRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAA 730
            L        A P S    +   PV +S  T         T +  P     P  + T    
Sbjct: 3247 LTTTTTGFTATPSSSPGTARTLPVWISTTTTPTTRGSTVTPSSIPGTTHTPTVLTTTTTT 3306

Query: 731  ASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLS 772
             +  S    + ST       TPP+    A      T G SLS
Sbjct: 3307 VATGSMATPSSSTQTSGTTHTPPVPNTTA-----TTHGRSLS 3343



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 115/527 (21%), Positives = 186/527 (35%), Gaps = 54/527 (10%)

Query: 278  PVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQ 337
            P T+S A P +   T      Q+   TTTA   + +A+   T     PP    S      
Sbjct: 3558 PATSSTATPSSTPGTTWILTEQTTAATTTATTGS-TAIPSSTPGTAPPPKVLTSTATTPT 3616

Query: 338  SRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTA-- 395
            +   +++ T  S P   T    L + A K+  ++ TP+ + T+     T T+P  TT   
Sbjct: 3617 A--TSSKATSSSSPRTATTLPVLTSTATKSTATSFTPIPSFTLG---TTGTLPEQTTTPM 3671

Query: 396  ---GSVSHTQAP----TSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPD 448
                ++  +  P    TST++T    +  + ++  T S+ P    +  ++T  +      
Sbjct: 3672 ATMSTIHPSSTPETTHTSTVLTTKATTTRATSSMSTPSSTPGTTWILTELTTAATTTAAT 3731

Query: 449  YPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPIT 508
             P    S  P          +  E  +    +VP        +   +A  L   T T  T
Sbjct: 3732 GPTATPSSTP------GTTWILTEPSTTATVTVPTGSTATASSTRATAGTLKVLTSTATT 3785

Query: 509  SSVSTIRQYPVSAQAPNSAITAQTGVGVAST-VHLNPMQLMTVDASHARHIQGIQP-API 566
             +V + R  P S+    +A+ A        T   +  +   ++  +  R  Q   P A +
Sbjct: 3786 PTVISSRATPSSSPGTATALPALRSTATTPTATSVTAIPSSSLGTAWTRLSQTTTPTATM 3845

Query: 567  STQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADG 626
            ST         TP   P  + T  + + T   T+        +  P     T+ V     
Sbjct: 3846 ST--------ATPSSTPETVHTSTVLTTTTTTTRATGSVATPSSTP-GTAHTTKVPTTTT 3896

Query: 627  ATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEI 686
                A P S+P +A      +      S +T    +GS+  PS +   P T      + +
Sbjct: 3897 TGFTATPSSSPGTALTPPVWI------STTTTPTTRGSTVTPSSI---PGT--THTATVL 3945

Query: 687  HVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQP-------AV 739
              +  T  T SM T S+      T   PP     P T  T    + PPS P         
Sbjct: 3946 TTTTTTVATGSMATPSSSTQTSGTTHTPPV----PNTTATTHGRSLPPSSPHTVRTAWTS 4001

Query: 740  ALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKE 786
            A S I G   IT P T  +  P  + +     +  L  P P  +  E
Sbjct: 4002 ATSGILGTTHITEPSTVTSHTPAATTSTTQHSTPALSSPHPSSRTTE 4048



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 95/427 (22%), Positives = 160/427 (37%), Gaps = 65/427 (15%)

Query: 243  SKVTTVLRPTSQLPNAAT--AQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQS 300
            +++TT    T    + AT  + P    I+     + P  T +  +P    AT S+T+A +
Sbjct: 3075 TELTTTATTTESTGSTATPSSTPGTTWIL-----TEPSTTATVTVPTGSTATASSTQATA 3129

Query: 301  --PVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQ 358
              P ++TTA   T ++      S     +A  +++  A +   T+   +PS  +LGT   
Sbjct: 3130 GTPHVSTTATTPTVTSSKATPFSSPGTATALPALRSTATTPTATSFTAIPS-SSLGTTWT 3188

Query: 359  QLHTMAQKTIFSTGTPVAA-ATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHS 417
            +L          T TP A  +T  P     T+ ++T   + + T   T ++ T +    +
Sbjct: 3189 RLS--------QTTTPTATMSTATPSSTPETVHTSTVLTTTATTTGATGSVATPSSTPGT 3240

Query: 418  SHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDN 477
            +H T V T+        P     T+                    R  P  ++  T    
Sbjct: 3241 AHTTKVLTTTTTGFTATPSSSPGTA--------------------RTLPVWISTTTTPTT 3280

Query: 478  RPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVA 537
            R S          T  PS+ P   HT T +T++ +T+        A  S  T  +    +
Sbjct: 3281 RGS----------TVTPSSIPGTTHTPTVLTTTTTTV--------ATGSMATPSSSTQTS 3322

Query: 538  STVHLNPMQLMTVDASHARHIQGIQPAPIST--QGIQPAPIGTPGIQPAPLGTQGIHSAT 595
             T H  P+   T   +H R +    P  + T         +GT  I     GT    +AT
Sbjct: 3323 GTTHTPPVP-NTTATTHGRSLSPSSPHTVRTAWTSATSGTLGTTHITEPSTGTSHTPAAT 3381

Query: 596  PINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHS--Q 653
               TQ   PA      P P  +T+    + G T   +  +   + A A  +  +T +   
Sbjct: 3382 TGTTQHSTPA---LSSPHPSSRTTESPPSPGTTTPGHTRATSRTTATATPSKTRTSTLLP 3438

Query: 654  SASTNAP 660
            S+ T+AP
Sbjct: 3439 SSPTSAP 3445



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 156/696 (22%), Positives = 246/696 (35%), Gaps = 92/696 (13%)

Query: 108  STHHAVASATPV---AVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSL 164
            S+    A+A P      T P A    A+P S          + T P+  ++ A PS  S 
Sbjct: 3796 SSSPGTATALPALRSTATTPTATSVTAIPSSSLGTAWTRLSQTTTPTATMSTATPS--ST 3853

Query: 165  PPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPG---- 220
            P  V     +T  ++  +A+   VAT S   G         TT    +   S++PG    
Sbjct: 3854 PETVHTSTVLTTTTTTTRATG-SVATPSSTPGTAHTTKVPTTTTTGFTATPSSSPGTALT 3912

Query: 221  PPLHIGASHLPR------------GAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHI 268
            PP+ I  +  P             G    A + ++  TTV   +   P+++T      H 
Sbjct: 3913 PPVWISTTTTPTTRGSTVTPSSIPGTTHTATVLTTTTTTVATGSMATPSSSTQTSGTTHT 3972

Query: 269  IHQPIQSRPPVTTSNAIPPAVVATVSA--TRAQSPVITTTAAHATDSALSRPTLSIQHPP 326
               P+ +    T   ++PP+   TV    T A S ++ TT  H T+     P+    H P
Sbjct: 3973 --PPVPNTTATTHGRSLPPSSPHTVRTAWTSATSGILGTT--HITE-----PSTVTSHTP 4023

Query: 327  SAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILAT 386
            +A             TT  T  S PAL +P     T        T +P +  T  P    
Sbjct: 4024 AA-------------TTSTTQHSTPALSSPHPSSRT--------TESPPSPGTTTPGHTR 4062

Query: 387  NTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHA--TAVTTSNIPVAKVVPQQITHTSPR 444
             T  S TTA     T  P+ T  +  +PS  + A  T V T+         + + ++ P 
Sbjct: 4063 GT--SRTTA-----TATPSKTRTSTLLPSSPTSAPITTVVTTGCEPQCAWSEWLDYSYPM 4115

Query: 445  IQPDY-PAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHT 503
              P     +  S I  +G      P+ +E R+  +P VP++ +          + L    
Sbjct: 4116 PGPSGGDFDTYSNIRAAGGAVCEQPLGLECRAQAQPGVPLR-ELGQVVECSLDFGLVCRN 4174

Query: 504  YTPITSSVSTIRQYPVSA------QAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARH 557
               +         Y +          P++  T+ T    ++      +  +T  A+    
Sbjct: 4175 REQV-GKFKMCFNYEIRVFCCNYGHCPSTPATSSTATPSSTPGTTWILTKLTTTATTTES 4233

Query: 558  IQGIQPAPISTQGI-----QPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAP-MGTQQ 611
              G    P ST G      +P+   T  +   P G+    +AT  +TQ     P + T  
Sbjct: 4234 T-GSTATPSSTPGTTWILTEPSTTATVTV---PTGS----TATASSTQATAGTPHVSTTA 4285

Query: 612  PQPEGKTS-AVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSI 670
              P   +S A   +   T  A P     +  P AT+     S S  T       +  P+ 
Sbjct: 4286 TTPTVTSSKATPFSSPGTATALPALRSTATTPTATSFTAIPSSSLGTTWTRLSQTTTPTA 4345

Query: 671  LRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPP-PTIPTMIA 729
                 AT  + P++  H S  T +T +  T     +     + P TA     PT  T   
Sbjct: 4346 TMST-ATPSSTPETA-HTS--TVLTTTATTTRATGSVATPSSTPGTAHTTKVPTTTTTGF 4401

Query: 730  AASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSV 765
              +P S P  A +        T P T+ +   P SV
Sbjct: 4402 TVTPSSSPGTARTPPVWISTTTTPTTSGSTVTPSSV 4437



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 118/536 (22%), Positives = 188/536 (35%), Gaps = 70/536 (13%)

Query: 274  QSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQ 333
            Q+    TT+     A+ ++   T     V+T+TA   T ++ S+ T S     +  + + 
Sbjct: 3579 QTTAATTTATTGSTAIPSSTPGTAPPPKVLTSTATTPTATS-SKATSSSSPRTATTLPVL 3637

Query: 334  RPAQSRDVTTRITLPSHPALGT----PKQQLHTMA-QKTIFSTGTPVAAATVAPILATNT 388
                ++   T  T      LGT    P+Q    MA   TI  + TP    T + +L T  
Sbjct: 3638 TSTATKSTATSFTPIPSFTLGTTGTLPEQTTTPMATMSTIHPSSTPETTHT-STVLTT-- 3694

Query: 389  IPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITH---TSPRI 445
               ATT  + S    P+ST  T  + +  + A   T +  P A       T    T P  
Sbjct: 3695 --KATTTRATSSMSTPSSTPGTTWILTELTTAATTTAATGPTATPSSTPGTTWILTEPST 3752

Query: 446  QPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYT 505
                     S    S  RA+   + + T +   P+V +  +    + P +A  L A   T
Sbjct: 3753 TATVTVPTGSTATASSTRATAGTLKVLTSTATTPTV-ISSRATPSSSPGTATALPALRST 3811

Query: 506  PITSSVSTIRQYPVSA-----------QAPNSAITAQTGVGVASTVHLNPMQLMTVDASH 554
              T + +++   P S+             P + ++  T      TVH + +   T   + 
Sbjct: 3812 ATTPTATSVTAIPSSSLGTAWTRLSQTTTPTATMSTATPSSTPETVHTSTVLTTTTTTTR 3871

Query: 555  ARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAP----MGTQ 610
            A    G    P ST        GT      P  T    +ATP ++ G    P      T 
Sbjct: 3872 A---TGSVATPSSTP-------GTAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTT 3921

Query: 611  QPQPEGKT-----------SAVVLADGATIVA-NPISNPFSAA---------PAATTVVQ 649
             P   G T           +A VL    T VA   ++ P S+          P   T   
Sbjct: 3922 TPTTRGSTVTPSSIPGTTHTATVLTTTTTTVATGSMATPSSSTQTSGTTHTPPVPNTTAT 3981

Query: 650  THSQSASTNAP----AQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQN 705
            TH +S   ++P       +S    IL     T+ +   S    +  +    S   +S+ +
Sbjct: 3982 THGRSLPPSSPHTVRTAWTSATSGILGTTHITEPSTVTSHTPAATTSTTQHSTPALSSPH 4041

Query: 706  NDQPTIAVPPTAQQPPP-----TIPTMIAAASPPSQPAVALSTIPGAVPITPPITT 756
                T   PP+     P     T  T   A    ++ +  L + P + PIT  +TT
Sbjct: 4042 PSSRTTESPPSPGTTTPGHTRGTSRTTATATPSKTRTSTLLPSSPTSAPITTVVTT 4097



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 175/754 (23%), Positives = 251/754 (33%), Gaps = 89/754 (11%)

Query: 115  SATPVAVTAPPAHLTPAVPLSF-SEGLMKPPPKP--------TMPSRPIAPAPPS---TL 162
            S TP A T    H TPA+     S    + PP P        T  SR  A A PS   T 
Sbjct: 4522 SHTPAATTGTTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATATPSKTRTS 4581

Query: 163  SLPPKVPGQV---TVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMS--IIRSN 217
            +L P  P      TV      PQ +       S     PS       +N++ +   +   
Sbjct: 4582 TLLPSSPTSAPITTVVTTGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSNIRAAGGAVCEQ 4641

Query: 218  APGPPLHIGASH-LPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHII-----HQ 271
              G      A   +P G     V  S     V R   Q+            +      H 
Sbjct: 4642 PLGLECRAQAQPGVPLGELGQVVECSLDFGLVCRNREQVGKFKMCFNYEIRVFCCNYGHC 4701

Query: 272  PIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAIS 331
            P     P T+S A+P +   T       +   TTTA+  + +A    T     PP    S
Sbjct: 4702 P---STPATSSTAMPSSTPGTTWILTELTTTATTTASTGS-TATPSSTPGTAPPPKVLTS 4757

Query: 332  IQRPAQSRDVTT-RITLPSHPALGTPKQQLHTMAQK------------TIFSTGTPVAAA 378
               PA +   T+ + T  S P   T    L + A K            T+ +TGT +   
Sbjct: 4758 ---PATTPTATSSKATSSSSPRTATTLPVLTSTATKSTATSVTPIPSSTLGTTGT-LPEQ 4813

Query: 379  TVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQI 438
            T  P+   +TI  ++T  +       TST++T    +  + ++  T S+ P    +  ++
Sbjct: 4814 TTTPVATMSTIHPSSTPETTH-----TSTVLTTKATTTRATSSTSTPSSTPGTTWILTEL 4868

Query: 439  THTSPRIQPDYPAERSSLIP----ISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPP 494
            T  +       P    S  P    I     +       T S   PS      + L     
Sbjct: 4869 TTAATTTAATGPTATPSSTPGTTWILTELTTTATTTASTGSTATPSSTPGTTWIL----- 4923

Query: 495  SAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASH 554
               P    T T  T S +T      +A  P+ + TA T   V S+         T  A  
Sbjct: 4924 -TEPSTTATVTVPTGSTATASSTQATAGTPHVSTTATTPT-VTSSKATPSSSPGTATALP 4981

Query: 555  ARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQP 614
            A       P   S   I  + +GT         T+   + TP  T          +    
Sbjct: 4982 ALRSTATTPTATSFTAIPSSSLGT-------TWTRLSQTTTPTATMSTATPSSTPETVHT 5034

Query: 615  EGKTSAVVLADGAT-IVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRK 673
                +A     GAT  VA P S P     A TT V T + +  T  P    S  P     
Sbjct: 5035 STVLTATATTTGATGSVATPSSTP---GTAHTTKVPTTTTTGFTATP----SSSPGTALT 5087

Query: 674  KPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIP-------- 725
             P T      S IH S +TP T    TV        T A   TA  P  T+         
Sbjct: 5088 PPTTTPMSTMSTIHTS-STPETTHTSTVLTTTATM-TRATNSTA-TPSSTLGTTRILTEL 5144

Query: 726  TMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVK 785
            T  A  +  +     LS+ PG   I    +TIA    P+ +   + S++     P++   
Sbjct: 5145 TTTATTTAATGSTATLSSTPGTTWILTEPSTIATVMVPTGSTATASSTLGTAHTPKVVTT 5204

Query: 786  EEVEPMDIMRPVSAVPPLATNTVSPSLALLANNL 819
                P       S VP  +T   + + A+L ++L
Sbjct: 5205 MATMP---TATASTVPSSSTVGTTRTPAVLPSSL 5235



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 126/546 (23%), Positives = 180/546 (32%), Gaps = 94/546 (17%)

Query: 39   STGLSQAPSQIANSGSAG--LINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPV 96
            STG +  PS    +      L +PA T    S + +  S+    ++   L S   K    
Sbjct: 4735 STGSTATPSSTPGTAPPPKVLTSPATTPTATSSKATSSSSPRTATTLPVLTSTATKSTAT 4794

Query: 97   VVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAP 156
             V P P   + +T        P   T P A ++   P S  E         T  +   A 
Sbjct: 4795 SVTPIPSSTLGTT-----GTLPEQTTTPVATMSTIHPSSTPETTHTSTVLTTKATTTRAT 4849

Query: 157  APPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRS 216
            +  ST S  P     +T    ++   A+  P AT S   G    L  + TT    +   S
Sbjct: 4850 SSTSTPSSTPGTTWILTELTTAATTTAATGPTATPSSTPGTTWILTELTTTATTTASTGS 4909

Query: 217  NA-----PGP------PLHIGASHLPRGAAAAAVMSSSKV------TTVLRPT------- 252
             A     PG       P       +P G+ A A  + +        TT   PT       
Sbjct: 4910 TATPSSTPGTTWILTEPSTTATVTVPTGSTATASSTQATAGTPHVSTTATTPTVTSSKAT 4969

Query: 253  -SQLPNAATAQPAVQHIIHQPIQSR---------------------PPVTTSNAIPPAVV 290
             S  P  ATA PA++     P  +                      P  T S A P +  
Sbjct: 4970 PSSSPGTATALPALRSTATTPTATSFTAIPSSSLGTTWTRLSQTTTPTATMSTATPSSTP 5029

Query: 291  ATVSATRAQSPVITTTAA--------------HATDSALSRPTLSIQHPPSAAISIQRPA 336
             TV  +   +   TTT A              H T    +  T     P S+  +   P 
Sbjct: 5030 ETVHTSTVLTATATTTGATGSVATPSSTPGTAHTTKVPTTTTTGFTATPSSSPGTALTPP 5089

Query: 337  QSRDVTTRITL-----PSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPS 391
             +  ++T  T+     P      T      TM + T  ST TP +      IL   T  +
Sbjct: 5090 TTTPMSTMSTIHTSSTPETTHTSTVLTTTATMTRATN-STATPSSTLGTTRILTELTTTA 5148

Query: 392  ATTAGS-----VSHTQAPT------STIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITH 440
             TTA +     +S T   T      STI T+ VP+ S+   + T       KVV    T 
Sbjct: 5149 TTTAATGSTATLSSTPGTTWILTEPSTIATVMVPTGSTATASSTLGTAHTPKVVTTMAT- 5207

Query: 441  TSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLA 500
                     P   +S +P S    +    A+   S    SV       L T  P+ +P +
Sbjct: 5208 --------MPTATASTVPSSSTVGTTRTPAVLPSSLPTFSVSTVSSSVLTTLRPTGFP-S 5258

Query: 501  AHTYTP 506
            +H  TP
Sbjct: 5259 SHFSTP 5264



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 145/639 (22%), Positives = 212/639 (33%), Gaps = 82/639 (12%)

Query: 243  SKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIP---PAVVATVSATRAQ 299
            S   TV  PT     A++ Q            + P VT+S A P   P     + A R+ 
Sbjct: 4254 STTATVTVPTGSTATASSTQATAGTPHVSTTATTPTVTSSKATPFSSPGTATALPALRST 4313

Query: 300  SPVITTTAAHATDSALSRPT---LSIQHPPSAAISIQRPAQSRDV--------TTRITLP 348
            +   T T+  A  S+    T   LS    P+A +S   P+ + +         TT  T  
Sbjct: 4314 ATTPTATSFTAIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETAHTSTVLTTTATTTR 4373

Query: 349  SHPALGTPKQQ---LHTMAQKTIFSTG-------TPVAAATVAPILATNTIPSATTAGSV 398
            +  ++ TP       HT    T  +TG       +P  A T    ++T T P  TT+GS 
Sbjct: 4374 ATGSVATPSSTPGTAHTTKVPTTTTTGFTVTPSSSPGTARTPPVWISTTTTP--TTSGST 4431

Query: 399  SHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIP 458
                +   T  T TV + ++   A  +   P +       THT P           SL P
Sbjct: 4432 VTPSSVPGTTHTPTVLTTTTTTVATGSMATPSSSTQTSGTTHTPPVPNTTATTHGRSLSP 4491

Query: 459  ISGHR-----ASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVST 513
             S H       S     + T     PS          ++ P+A        TP  SS   
Sbjct: 4492 SSPHTVRTAWTSATSGTLGTTHITEPSTGT-------SHTPAATTGTTQHSTPALSSPHP 4544

Query: 514  IRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPIS---TQG 570
              +   S  +P +     T     +T    P +  T     +        API+   T G
Sbjct: 4545 SSRTTESPPSPGTTTPGHTTATSRTTATATPSKTRTSTLLPSSPTS----APITTVVTTG 4600

Query: 571  IQPAPIGTPGIQ---PAPLGTQGIHSATPINTQGLQPA----PMG------TQQPQPEGK 617
             +P    +  +    P P G  G    T  N +    A    P+G       Q   P G+
Sbjct: 4601 CEPQCAWSEWLDYSYPMP-GPSGGDFDTYSNIRAAGGAVCEQPLGLECRAQAQPGVPLGE 4659

Query: 618  TSAVV---LADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKK 674
               VV   L  G           F         V   +     + PA  S+  PS     
Sbjct: 4660 LGQVVECSLDFGLVCRNREQVGKFKMCFNYEIRVFCCNYGHCPSTPATSSTAMPS---ST 4716

Query: 675  PATDGAKPKSEIHVSMATPVTVSMETVSNQN-NDQPTIAVPPTAQQPPPTIPTMIAAASP 733
            P T      + I   + T  T +  T S    +  P  A PP     P T PT  ++ + 
Sbjct: 4717 PGT------TWILTELTTTATTTASTGSTATPSSTPGTAPPPKVLTSPATTPTATSSKAT 4770

Query: 734  PSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDI 793
             S      +T+P         T  +  P PS T+G +        +PE +    V  M  
Sbjct: 4771 SSSSPRTATTLPVLTSTATKSTATSVTPIPSSTLGTT------GTLPE-QTTTPVATMST 4823

Query: 794  MRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASP 832
            + P S      T+TV   L   A      +S   P ++P
Sbjct: 4824 IHPSSTPETTHTSTV---LTTKATTTRATSSTSTPSSTP 4859



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 106/455 (23%), Positives = 155/455 (34%), Gaps = 66/455 (14%)

Query: 361  HTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHA 420
            H  +     ST TP +      IL   T  +ATT  +   T  P+ST  T   P      
Sbjct: 3553 HCPSTPATSSTATPSSTPGTTWILTEQTT-AATTTATTGSTAIPSSTPGTAPPPK----- 3606

Query: 421  TAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPS 480
               +T+  P A    +  + +SPR     P   S+    +    +P P      +   P 
Sbjct: 3607 VLTSTATTPTA-TSSKATSSSSPRTATTLPVLTSTATKSTATSFTPIPSFTLGTTGTLPE 3665

Query: 481  VPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTV 540
                    + T  PS+ P   HT T +T+  +T R    S+ +  S+    T +    T 
Sbjct: 3666 QTTTPMATMSTIHPSSTPETTHTSTVLTTKATTTRA--TSSMSTPSSTPGTTWILTELTT 3723

Query: 541  HLNPMQLMTVDASHARHIQGIQPAPISTQGI-----QPAPIGTPGIQPAPLGTQGIHSAT 595
                       A+      G    P ST G      +P+   T  +   P G+    S+T
Sbjct: 3724 -----------AATTTAATGPTATPSSTPGTTWILTEPSTTATVTV---PTGSTATASST 3769

Query: 596  PINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSA 655
               T G       T        + A   +   T  A P     +  P AT+V    S S 
Sbjct: 3770 RA-TAGTLKVLTSTATTPTVISSRATPSSSPGTATALPALRSTATTPTATSVTAIPSSSL 3828

Query: 656  STNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPP 715
             T       +  P+      AT  + P++ +H S  T +T +  T     +     + P 
Sbjct: 3829 GTAWTRLSQTTTPTATMST-ATPSSTPET-VHTS--TVLTTTTTTTRATGSVATPSSTPG 3884

Query: 716  TAQQPP-PTIPTMIAAASPPSQPAVAL---------------------STIPG----AVP 749
            TA     PT  T    A+P S P  AL                     S+IPG    A  
Sbjct: 3885 TAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTRGSTVTPSSIPGTTHTATV 3944

Query: 750  ITPPITTIA----AAPPPSVTVGGSLSSVLGPPVP 780
            +T   TT+A    A P  S    G+  +   PPVP
Sbjct: 3945 LTTTTTTVATGSMATPSSSTQTSGTTHT---PPVP 3976



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 101/438 (23%), Positives = 153/438 (34%), Gaps = 80/438 (18%)

Query: 361  HTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPT------------STI 408
            H  +     ST TP +      IL T    +ATT  S   T  P+            ST 
Sbjct: 4198 HCPSTPATSSTATPSSTPGTTWIL-TKLTTTATTTESTGSTATPSSTPGTTWILTEPSTT 4256

Query: 409  VTMTVPSHSSH--------------ATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERS 454
             T+TVP+ S+               +T  TT  +  +K  P     +SP      PA RS
Sbjct: 4257 ATVTVPTGSTATASSTQATAGTPHVSTTATTPTVTSSKATP----FSSPGTATALPALRS 4312

Query: 455  SLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTI 514
            +    +    +  P +    +  R S        + T  PS+ P  AHT T +T++ +T 
Sbjct: 4313 TATTPTATSFTAIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETAHTSTVLTTTATTT 4372

Query: 515  RQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPA 574
            R       A  S  T  +  G A T  +                        +T G    
Sbjct: 4373 R-------ATGSVATPSSTPGTAHTTKV---------------------PTTTTTGFTVT 4404

Query: 575  PIGTPGIQPAPLGTQGIHSATPINTQGLQPAPM---GTQQPQPEGKTSAVVLADGATIVA 631
            P  +PG    P     I + T   T G    P    GT        T+   +A G+  +A
Sbjct: 4405 PSSSPGTARTP--PVWISTTTTPTTSGSTVTPSSVPGTTHTPTVLTTTTTTVATGS--MA 4460

Query: 632  NPISNPFSAA-----PAATTVVQTHSQSASTNAP----AQGSSPRPSILRKKPATDGAKP 682
             P S+  ++      P   T   TH +S S ++P       +S     L     T+ +  
Sbjct: 4461 TPSSSTQTSGTTHTPPVPNTTATTHGRSLSPSSPHTVRTAWTSATSGTLGTTHITEPSTG 4520

Query: 683  KSEIHVSMATPVTVSMET--VSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPA-V 739
             S  H   AT  T    T  +S+ +    T   PP+     P   T  +  +  + P+  
Sbjct: 4521 TS--HTPAATTGTTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATATPSKT 4578

Query: 740  ALSTIPGAVPITPPITTI 757
              ST+  + P + PITT+
Sbjct: 4579 RTSTLLPSSPTSAPITTV 4596



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 116/530 (21%), Positives = 172/530 (32%), Gaps = 58/530 (10%)

Query: 39   STGLSQAPSQIANSGSAG--LINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPV 96
            +TG +  PS    +      L + A T    S + +  S+    ++   L S   K    
Sbjct: 3588 TTGSTAIPSSTPGTAPPPKVLTSTATTPTATSSKATSSSSPRTATTLPVLTSTATKSTAT 3647

Query: 97   VVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAP 156
               P P   + +T        P   T P A ++   P S  E          + ++    
Sbjct: 3648 SFTPIPSFTLGTT-----GTLPEQTTTPMATMSTIHPSSTPE---TTHTSTVLTTKATTT 3699

Query: 157  APPSTLSLPPKVPGQVTVTME---SSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSI 213
               S++S P   PG   +  E   ++   A+  P AT S   G    L    TT      
Sbjct: 3700 RATSSMSTPSSTPGTTWILTELTTAATTTAATGPTATPSSTPGTTWILTEPSTTATVTVP 3759

Query: 214  IRSNAPGPPLHIGASHLP--RGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQ 271
              S A        A  L      A    + SS+ T      S  P  ATA PA++     
Sbjct: 3760 TGSTATASSTRATAGTLKVLTSTATTPTVISSRATP-----SSSPGTATALPALRSTA-- 3812

Query: 272  PIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAIS 331
               + P  T+  AIP + + T     +Q+   T T + AT S+               + 
Sbjct: 3813 ---TTPTATSVTAIPSSSLGTAWTRLSQTTTPTATMSTATPSSTPE-----------TVH 3858

Query: 332  IQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTG-------TPVAAATVAPIL 384
                  +   TTR T        TP    HT    T  +TG       +P  A T    +
Sbjct: 3859 TSTVLTTTTTTTRATGSVATPSSTPGTA-HTTKVPTTTTTGFTATPSSSPGTALTPPVWI 3917

Query: 385  ATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPR 444
            +T T P  TT GS     +   T  T TV + ++   A  +   P +       THT P 
Sbjct: 3918 STTTTP--TTRGSTVTPSSIPGTTHTATVLTTTTTTVATGSMATPSSSTQTSGTTHTPPV 3975

Query: 445  IQPDYPAERSSLIPISGHR-----ASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPL 499
                      SL P S H       S     + T     PS        + ++ P+A   
Sbjct: 3976 PNTTATTHGRSLPPSSPHTVRTAWTSATSGILGTTHITEPST-------VTSHTPAATTS 4028

Query: 500  AAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMT 549
                 TP  SS     +   S  +P +     T     +T    P +  T
Sbjct: 4029 TTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTRGTSRTTATATPSKTRT 4078



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 143/589 (24%), Positives = 198/589 (33%), Gaps = 123/589 (20%)

Query: 251  PTSQLPNAATAQPAVQHIIHQPIQS----RPPVTTSNAIPPAVVATVSATRAQSPVITTT 306
            PT++L  A T          QP  S    R P  ++ A+P       S     +    TT
Sbjct: 2305 PTTELETATTTTTQALFSTPQPTSSPGLTRAPPASTTAVPTLSEGLTSPRYTSTLGTATT 2364

Query: 307  AAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHP-ALGTPK-QQLHTMA 364
                T +  + PT+     P  A S         + TR  LP    +LGT +  Q  T+A
Sbjct: 2365 GGPTTPAGSTEPTV-----PGVATST--------LPTRSALPGTTGSLGTWRPSQPPTLA 2411

Query: 365  QKTIF-STGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAV 423
              T+  S   P   A+ A      T  + T    +S +QA TST  T T     S  T  
Sbjct: 2412 PTTMATSRARPTGTASTASKEPLTTSLAPTLTSELSTSQAETSTPRTETT---MSPLTNT 2468

Query: 424  TTSNIPVAKVVPQQITHTSPRIQ------PDYPA--------ERSSLIPISGHRASPNPV 469
            TTS         Q  T   P+ +       D+P         E    I  +G +    P 
Sbjct: 2469 TTS---------QGTTRCQPKCEWTEWFDVDFPTSGVAGGDMETFENIRAAGGKMCWAPK 2519

Query: 470  AMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAIT 529
            ++E R++N P V +                       +T S+ T           N   T
Sbjct: 2520 SIECRAENYPEVSID-----------------QVGQVLTCSLET------GLTCKNEDQT 2556

Query: 530  AQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQ 589
             +  +      + N   L   D SH        PA  ST      P GT  I   P  T 
Sbjct: 2557 GRFNM----CFNYNVRVLCCDDYSHCPST----PATSSTATPSSTP-GTTWILTKPTTTA 2607

Query: 590  GI-----HSATPINTQGLQPAP--MGTQQPQPEGKTS-AVVLADGATIVANPISNPFSAA 641
                    +ATP +T    P P  + T    P   +S A   +   T  A P     +  
Sbjct: 2608 TTTASTGSTATPTSTLRTAPPPKVLTTTATTPTVTSSKATPSSSPGTATALPALRSTATT 2667

Query: 642  PAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETV 701
            P AT+V    S S  T       +  P+      AT  + P++  H S  T +T +  T 
Sbjct: 2668 PTATSVTPIPSSSLGTTWTRLSQTTTPTATMST-ATPSSTPETA-HTS--TVLTATATTT 2723

Query: 702  SNQNNDQPTIAVPPTAQQPP-PTIPTMIAAASPPSQPAVAL------------------- 741
                +     + P TA     PT  T    A+P S P  AL                   
Sbjct: 2724 GATGSVATPSSTPGTAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTRGSTV 2783

Query: 742  --STIPG----AVPITPPITTIA----AAPPPSVTVGGSLSSVLGPPVP 780
              S+IPG    A  +T   TT+A    A P  S    G+  +   PPVP
Sbjct: 2784 TPSSIPGTTHTATVLTTTTTTVATGSMATPSSSTQTSGTTHT---PPVP 2829



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 100/436 (22%), Positives = 153/436 (35%), Gaps = 92/436 (21%)

Query: 373  TPVAAATVAPI-------LATNTIPSATTAGSVSHTQAPT------------STIVTMTV 413
            TP  ++T  P        + T    +ATT  S   T  P+            ST  T+TV
Sbjct: 3055 TPATSSTAMPSSTPGTTWILTELTTTATTTESTGSTATPSSTPGTTWILTEPSTTATVTV 3114

Query: 414  PSHSSH--------------ATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPI 459
            P+ S+               +T  TT  +  +K  P     +SP      PA RS+    
Sbjct: 3115 PTGSTATASSTQATAGTPHVSTTATTPTVTSSKATP----FSSPGTATALPALRSTATTP 3170

Query: 460  SGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPV 519
            +    +  P +    +  R S        + T  PS+ P   HT T +T++ +T      
Sbjct: 3171 TATSFTAIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETVHTSTVLTTTATT------ 3224

Query: 520  SAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTP 579
               A  S  T  +  G A T      +++T                 +T G    P  +P
Sbjct: 3225 -TGATGSVATPSSTPGTAHTT-----KVLTT----------------TTTGFTATPSSSP 3262

Query: 580  GIQPAPLGTQGIHSATPINTQGLQPAPM---GTQQPQPEGKTSAVVLADGATIVANPISN 636
            G   A      I + T   T+G    P    GT        T+   +A G+  +A P S+
Sbjct: 3263 G--TARTLPVWISTTTTPTTRGSTVTPSSIPGTTHTPTVLTTTTTTVATGS--MATPSSS 3318

Query: 637  PFSAA-----PAATTVVQTHSQSASTNAP----AQGSSPRPSILRKKPATDGAKPKSEIH 687
              ++      P   T   TH +S S ++P       +S     L     T+ +   S  H
Sbjct: 3319 TQTSGTTHTPPVPNTTATTHGRSLSPSSPHTVRTAWTSATSGTLGTTHITEPSTGTS--H 3376

Query: 688  VSMATPVTVSMET--VSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPA----VAL 741
               AT  T    T  +S+ +    T   PP+   P  T P    A S  +  A       
Sbjct: 3377 TPAATTGTTQHSTPALSSPHPSSRTTESPPS---PGTTTPGHTRATSRTTATATPSKTRT 3433

Query: 742  STIPGAVPITPPITTI 757
            ST+  + P + PITT+
Sbjct: 3434 STLLPSSPTSAPITTV 3449



 Score = 32.0 bits (71), Expect = 3.1
 Identities = 46/202 (22%), Positives = 78/202 (38%), Gaps = 24/202 (11%)

Query: 639  SAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSM 698
            +  P  TT ++T   + +T   A  S+P+P+     P    A P S          T ++
Sbjct: 2300 ATTPPPTTELET---ATTTTTQALFSTPQPT---SSPGLTRAPPAS----------TTAV 2343

Query: 699  ETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIP--GAVP-ITPPIT 755
             T+S         +   TA    PT P   A ++ P+ P VA ST+P   A+P  T  + 
Sbjct: 2344 PTLSEGLTSPRYTSTLGTATTGGPTTP---AGSTEPTVPGVATSTLPTRSALPGTTGSLG 2400

Query: 756  TIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALL 815
            T   + PP++      +S   P        +  EP+      +    L+T+    S    
Sbjct: 2401 TWRPSQPPTLAPTTMATSRARPTGTASTASK--EPLTTSLAPTLTSELSTSQAETSTPRT 2458

Query: 816  ANNLSMPTSDLPPGASPRKKPR 837
               +S  T+      + R +P+
Sbjct: 2459 ETTMSPLTNTTTSQGTTRCQPK 2480



 Score = 32.0 bits (71), Expect = 3.1
 Identities = 33/151 (21%), Positives = 52/151 (34%), Gaps = 12/151 (7%)

Query: 690  MATPVTVSMETVSNQNNDQPT----IAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIP 745
            +  P T +  T S  +   PT     A PP       T PT+ ++ + PS      + +P
Sbjct: 2600 LTKPTTTATTTASTGSTATPTSTLRTAPPPKVLTTTATTPTVTSSKATPSSSPGTATALP 2659

Query: 746  GAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLAT 805
                     T  +  P PS ++G + + +     P          M    P S      T
Sbjct: 2660 ALRSTATTPTATSVTPIPSSSLGTTWTRLSQTTTP-------TATMSTATPSSTPETAHT 2712

Query: 806  NTVSPSLALLANNL-SMPTSDLPPGASPRKK 835
            +TV  + A       S+ T    PG +   K
Sbjct: 2713 STVLTATATTTGATGSVATPSSTPGTAHTTK 2743


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
           sapiens]
          Length = 1560

 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 168/757 (22%), Positives = 252/757 (33%), Gaps = 192/757 (25%)

Query: 115 SATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPK--VPGQV 172
           S  P+AV AP    +P VP      ++   P P  P +P    PP    L PK   P   
Sbjct: 321 SGQPLAV-APGLGSSPLVPAP--NVILHRTPTPIQP-KPAGVLPPKLYQLTPKPFAPAGA 376

Query: 173 TVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPR 232
           T+T++    +  A+P      Q   P NL  +       +++ S  P P L         
Sbjct: 377 TLTIQG---EPGALPQ-----QPKAPQNLTFMAAGKAGQNVVLSGFPAPALQAN------ 422

Query: 233 GAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVAT 292
                                                   +  +PP TT+ A PP     
Sbjct: 423 ----------------------------------------VFKQPPATTTGAAPP----- 437

Query: 293 VSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSR-DVTTRITLPSHP 351
                 Q P            ALS+P +S+ H  +   SI  PAQ       +  LP  P
Sbjct: 438 ------QPP-----------GALSKP-MSV-HLLNQGSSIVIPAQHMLPGQNQFLLPGAP 478

Query: 352 ALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTM 411
           A+  P QQL  +            A  T   ++A   + +   AG +S        ++  
Sbjct: 479 AVQLP-QQLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAGPLS-----LGPVLAP 532

Query: 412 TVPSHSSHATAVTTSNI--PVAKVVPQQITHTS-PRIQPDYPAERSSLIPISGHRASPNP 468
              +HS+H  +     +  P    +P  +   S P      PA  ++   + G    P+ 
Sbjct: 533 HSGAHSAHILSAAPIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPSA 592

Query: 469 VAMETRSDN--RPSVPV----QFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVS-- 520
           VAM    D   +P+ P     +    L   P    P A  T  P+       +Q P +  
Sbjct: 593 VAMLNTPDGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPT 652

Query: 521 --AQAPNSAITAQTGVGVASTVH---------LNPMQLMTVDASHARHIQGIQPAPISTQ 569
             A AP  A T Q   G+AS+             P  ++T D+     +Q   P   S Q
Sbjct: 653 PQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDS-----LQMFLPQERSQQ 707

Query: 570 GIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATI 629
                          PL  +G H + P +   +  AP   Q P P     A  +A GA +
Sbjct: 708 ---------------PLSAEGPHLSVPASV--IVSAPPPAQDPAP-----ATPVAKGAGL 745

Query: 630 VANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVS 689
                 +  S APA           A+      G S  PS+  + P              
Sbjct: 746 GPQAPDSQASPAPAPQI-------PAAAPLKGPGPSSSPSLPHQAPL------------- 785

Query: 690 MATPVTVSMETVSNQNNDQPTIAVPPTAQQP--PPTIPTMIAAASPPSQPAVALSTIPGA 747
                            D P +  P   + P  PP+ P  ++   PPS+P +     P A
Sbjct: 786 ----------------GDSPHLPSPHPTRPPSRPPSRPQSVSR--PPSEPPLHPCPPPQA 827

Query: 748 VPITPPITTI---AAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLA 804
            P  P I  I      PPP+        +  GPP P ++ + +  P   + P   +PP +
Sbjct: 828 PPTLPGIFVIQNQLGVPPPA---SNPAPTAPGPPQPPLRPQSQ-PPEGPLPPAPHLPPSS 883

Query: 805 TNTVSPSLALLANNLSMPTS-----DLPPGASPRKKP 836
           T++   S +  ++ L  PT        PP   P K P
Sbjct: 884 TSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKSP 920



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 170/825 (20%), Positives = 289/825 (35%), Gaps = 144/825 (17%)

Query: 104  VQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKP-PPKPTMPSRPIAPAPPSTL 162
            VQ  +   A   A PV    P     PAV      GL +P   +P     P A APP   
Sbjct: 603  VQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQA- 661

Query: 163  SLPPKVPGQVTVTMESSIPQ-ASAIPVATIS------------GQQGHPSNLHHIMTTNV 209
            + P   PG  +   +  + Q  SA P A ++             QQ   +   H+   +V
Sbjct: 662  TTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHL---SV 718

Query: 210  QMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAA-------TAQ 262
              S+I S  P       A+ + +GA        S+ +    P  Q+P AA       ++ 
Sbjct: 719  PASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPA--PAPQIPAAAPLKGPGPSSS 776

Query: 263  PAVQH---IIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPT 319
            P++ H   +   P    P  T   + PP+   +VS   ++ P+      H      + PT
Sbjct: 777  PSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPL------HPCPPPQAPPT 830

Query: 320  LSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAAT 379
            L         + +  PA +         P+  A G P+  L   +Q        P     
Sbjct: 831  LPGIFVIQNQLGVPPPASN---------PAPTAPGPPQPPLRPQSQ-------PPEGPLP 874

Query: 380  VAPILATNTIPSATTAGS--VSHTQAPTSTIVTMTVP----SHSSHATAVTTSNIPVAKV 433
             AP L  ++  SA  + S   S   APT +   +  P     H S     T   +P    
Sbjct: 875  PAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKSPTPPPTLHLVPEPAA 934

Query: 434  VP-------QQITHTSPRI-QPDYPAERSSLIP---ISGHRASPNPVAMETRSDNRP--- 479
             P       Q +T   P + QP    ER   +P   I  ++A   P A +T +   P   
Sbjct: 935  PPPPPPRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTS 994

Query: 480  ---SVPVQFQY-----FLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQ 531
               SV V  Q        P++ P+  P+AA    P+  + +  + +  +    N A  A 
Sbjct: 995  PAASVLVSGQAPSGTPTAPSHAPAPAPMAATGLPPLLPAEN--KAFASNLPTLNVAKAAS 1052

Query: 532  TGVGVASTVHLN---------PMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQ 582
            +G G  S +            P    + +A    H+   Q + +            P  +
Sbjct: 1053 SGPGKPSGLQYESKLSGLKKPPTLQPSKEACFLEHLHKHQGSVLH-----------PDYK 1101

Query: 583  PA-PLGTQGIHSATPINT-QGLQPAPMGTQQPQPEGKTSAVVLADGATIVANP-----IS 635
             A P     +H   P +  QG  P+P    +   E +T +  L      + N      + 
Sbjct: 1102 TAFPSFEDALHRLLPYHVYQGALPSPSDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLE 1161

Query: 636  NPFSAAPAATTVV--QTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATP 693
                 +P+A  V+  +   Q   T            + ++KP    +  +     S+  P
Sbjct: 1162 ESRRVSPSAEMVMIDRMFIQEEKTTLALD-----KQLAKEKPDEYVSSSR-----SLGLP 1211

Query: 694  VTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPP 753
            +  S E      +   + + P  + QPPP +PT +      +  + +++    +  ++  
Sbjct: 1212 IAASSEGHRLPGHGPLSSSAPGASTQPPPHLPTKLVIRHGGAGGSPSVTWARASSSLSSS 1271

Query: 754  ITTIAAAPPPSVTVGGSLSSVLGPPVP----------EIKVKEEVEPMDIMRPVSAVPPL 803
             ++ +AA        G + S   PP+           ++K+K+E     ++   +A+ P+
Sbjct: 1272 SSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLSKVVHN-TALDPV 1330

Query: 804  ATNTVSPSLALLANNLSMP------------TSDLPPGASPRKKP 836
                  P+   +A     P            T D PP A+P +KP
Sbjct: 1331 HQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPERKP 1375



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 138/622 (22%), Positives = 205/622 (32%), Gaps = 116/622 (18%)

Query: 140  LMKPPPKPTMPSRPIAPAPPSTLSLPPKV-----------------PGQVTVTMESS--- 179
            + K PP  T  + P  P PP  LS P  V                 PGQ    +  +   
Sbjct: 423  VFKQPPATTTGAAP--PQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGAPAV 480

Query: 180  -IPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPR-GAAAA 237
             +PQ  +   A + GQ    +  H          +   N  GP L +G    P  GA +A
Sbjct: 481  QLPQQLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAGP-LSLGPVLAPHSGAHSA 539

Query: 238  AVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTT---SNAIPPAVVATVS 294
             ++S++ +        Q+P +  A         QP  + P  TT      +PP+ VA ++
Sbjct: 540  HILSAAPIQVGQPALFQMPVSLAAGSLPTQ--SQPAPAGPAATTVLQGVTLPPSAVAMLN 597

Query: 295  -------------ATRAQSPVITTTAAHATDSALSRPT-LSIQHPPSAAISIQRPAQSRD 340
                         AT   +PV+T   A     A+S P  L +Q P +     Q+P Q+  
Sbjct: 598  TPDGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQA-----QQPPQAP- 651

Query: 341  VTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNT---IPSATTAGS 397
             T +   P       P   L +  +K +   G P +A   A +   +    +P   +   
Sbjct: 652  -TPQAAAPPQATTPQPSPGLASSPEKIVL--GQPPSATPTAILTQDSLQMFLPQERSQQP 708

Query: 398  VS----HTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPA-- 451
            +S    H   P S IV+   P+              +    P   +  SP   P  PA  
Sbjct: 709  LSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPD--SQASPAPAPQIPAAA 766

Query: 452  -------ERSSLIPI------SGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYP 498
                     S  +P       S H  SP+P    +R  +RP    +     P   P  +P
Sbjct: 767  PLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSR-----PPSEPPLHP 821

Query: 499  LAAHTYTPITSSVSTIR-QYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARH 557
                   P    +  I+ Q  V   A N A TA             P +     A H   
Sbjct: 822  CPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPP 881

Query: 558  IQGIQPAPISTQGIQPAPIGTPG---IQPAPLGTQGIH-SATPINTQGLQPAPMGTQQPQ 613
                     S++     P  TP    +Q  P  +QG H S TP  T  L P P     P 
Sbjct: 882  SSTSSAVASSSETSSRLPAPTPSDFQLQFPP--SQGPHKSPTPPPTLHLVPEPAAPPPPP 939

Query: 614  PEG-----------------------KTSAVVLAD--GATIVANPISNPFS--AAPAATT 646
            P                           S ++L +  G    A   S       +PAA+ 
Sbjct: 940  PRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPAASV 999

Query: 647  VVQTHSQSASTNAPAQGSSPRP 668
            +V   + S +  AP+   +P P
Sbjct: 1000 LVSGQAPSGTPTAPSHAPAPAP 1021


>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
          Length = 1427

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 123/537 (22%), Positives = 195/537 (36%), Gaps = 92/537 (17%)

Query: 237  AAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVAT-VSA 295
            AA +S+ +  TV   T  +P    A  AV            P  T+ A+  A+    +SA
Sbjct: 898  AAAVSAPERATVPAVTVSVPEGTAAVAAVSS----------PEETAPAVAAAITQEGMSA 947

Query: 296  TRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGT 355
                SP     AA A    ++    + + P + A ++  P +      R++ P  PA  +
Sbjct: 948  VAGFSP---EWAALAITVPITEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPA--S 1002

Query: 356  PKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATT-AGSVSHTQAPTSTIVTMTVP 414
            P   + T  + T  +   P      +P  A       T+ A +V   + PTS    +  P
Sbjct: 1003 PAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTP 1062

Query: 415  SH-SSHATAVTTSNIPV--AKVVPQQITHTSPRIQ---PDYPAERSSLIPISGHRASPNP 468
               +S A AV T   P   A  VP     TSP      P+ P   ++ +P     ASP  
Sbjct: 1063 EEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASP-A 1121

Query: 469  VAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAI 528
             A+ T     P  P      +PT    A+P  A      ++S +     P  + +P +A+
Sbjct: 1122 AAVPT-----PEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAV 1176

Query: 529  TAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGT 588
                           P +  +  A  A   +   PA         A + TP    A L  
Sbjct: 1177 PT-------------PAESASFAAVVATLEEPTSPA---------ASVPTPAAMVATLEE 1214

Query: 589  QGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVV 648
                +A+   ++  +PA +      PE  TS              +  P S+A A  T  
Sbjct: 1215 FTSPAASVPTSE--EPASLAAAVSNPEEPTSPAAAVP-------TLEEPTSSAAAVLTPE 1265

Query: 649  QTHSQSASTNAPAQGSSPRPSILR-KKPATDGAKPKSEIHVSMATPVTVSMETVSNQNND 707
            +  S +AS   P + +SP  ++   ++PA+  A          A P              
Sbjct: 1266 ELSSPAASVPTPEEPASPAAAVSNLEEPASPAA----------AVPT------------- 1302

Query: 708  QPTIAVPPTAQQPPPTIPTMIAAASPPSQ-------PAVALSTIPGAVPITPPITTI 757
             P +A  P A  P P +P + AAA PP +       P + +S    +VPI+   T +
Sbjct: 1303 -PEVAAIPAASVPTPEVPAIPAAAVPPMEEVSPIGVPFLGVSAHTDSVPISEEGTPV 1358



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 144/633 (22%), Positives = 215/633 (33%), Gaps = 119/633 (18%)

Query: 251  PTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSP--------V 302
            P  Q P+   A P V+  +   + S    T+  A+P      V A     P        +
Sbjct: 829  PVLQRPSRTAAVPTVKDALDAALPSPEEGTSIAAVPAPEGTAVVAALVPFPHEDILVASI 888

Query: 303  ITTTAAHATDSALSRP--------TLSIQHPPSAAISIQRPAQSRD-VTTRITLPSHPAL 353
            ++      T +A+S P        T+S+    +A  ++  P ++   V   IT     A+
Sbjct: 889  VSLEEEDVTAAAVSAPERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAAITQEGMSAV 948

Query: 354  G--TPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTM 411
               +P+     +        GTP    T A  +     P  T A  VS  + P S    +
Sbjct: 949  AGFSPEWAALAITVPITEEDGTPEGPVTPATTVHAPEEPD-TAAVRVSTPEEPASPAAAV 1007

Query: 412  TVPSH-SSHATAVTTSNIPV--AKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNP 468
              P   +S A AV T   P   A  VP     TSP      P E     P S   A P P
Sbjct: 1008 PTPEEPTSPAAAVPTPEEPTSPAAAVPPPEEPTSPAAAVPTPEE-----PTSPAAAVPTP 1062

Query: 469  VAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAI 528
               E  +    +VP   +   PT P +A P      +P  ++V T    P    +P +A+
Sbjct: 1063 ---EEPTSPAAAVPTPEE---PTSPAAAVPTPEEPTSP-AAAVPT----PEEPTSPAAAV 1111

Query: 529  TAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGT 588
                                              P P         P       P P   
Sbjct: 1112 ----------------------------------PTP-------EEPASPAAAVPTPEEP 1130

Query: 589  QGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAAT--T 646
                +A P   +   PAP     P PE   SA V        A+P +   + A +A+   
Sbjct: 1131 ASPAAAVPTPEEPAFPAPA---VPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAA 1187

Query: 647  VVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVT---------VS 697
            VV T  +  S  A     +   + L +  +   + P SE   S+A  V+          +
Sbjct: 1188 VVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPAAA 1247

Query: 698  METVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASP---------PSQPAVALST----- 743
            + T+    +    +  P     P  ++PT    ASP         P+ PA A+ T     
Sbjct: 1248 VPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPEVAA 1307

Query: 744  IPGAVPITPPITTI-AAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPP 802
            IP A   TP +  I AAA PP   V     S +G  VP + V    + + I    + V  
Sbjct: 1308 IPAASVPTPEVPAIPAAAVPPMEEV-----SPIG--VPFLGVSAHTDSVPISEEGTPVLE 1360

Query: 803  LATNT---VSPSLALLANNLSMPTSDLPPGASP 832
             A++T   +   L  L   +   TS +  G  P
Sbjct: 1361 EASSTGMWIKEDLDSLVFGIKEVTSTVLHGKVP 1393



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 83/358 (23%), Positives = 126/358 (35%), Gaps = 50/358 (13%)

Query: 59   NPAATVNDESGRDSEVSA----REHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVA 114
            +PAA V       S  +A     E  S ++++ + EE   P    P P+     T  A A
Sbjct: 1028 SPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEP---TSPAAA 1084

Query: 115  SATPVAVTAPPAHL-TPAVPLSFSEGLMKP--PPKPTM----PSRPIAPAPPSTLSLPPK 167
              TP   T+P A + TP  P S +  +  P  P  P      P  P +PA        P 
Sbjct: 1085 VPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPA 1144

Query: 168  VPGQVTVTMESSIPQASAIPV--ATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHI 225
             P     T E S   A A+P    + S     P+         V  ++    +P      
Sbjct: 1145 FPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPTSP------ 1198

Query: 226  GASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAI 285
             A+ +P  AA  A +          PTS+ P +  A             S P   TS   
Sbjct: 1199 -AASVPTPAAMVATLEEFTSPAASVPTSEEPASLAA-----------AVSNPEEPTS--- 1243

Query: 286  PPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRI 345
            P A V T+     + P  ++ AA  T   LS P  S+  P       + PA      + +
Sbjct: 1244 PAAAVPTL-----EEPT-SSAAAVLTPEELSSPAASVPTP-------EEPASPAAAVSNL 1290

Query: 346  TLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQA 403
              P+ PA   P  ++  +   ++ +   P   A   P +   +       G  +HT +
Sbjct: 1291 EEPASPAAAVPTPEVAAIPAASVPTPEVPAIPAAAVPPMEEVSPIGVPFLGVSAHTDS 1348



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 111/525 (21%), Positives = 176/525 (33%), Gaps = 89/525 (16%)

Query: 61   AATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVAS---AT 117
            AA    +   D+ + + E  +S +++ + E       + P+P   +L            T
Sbjct: 838  AAVPTVKDALDAALPSPEEGTSIAAVPAPEGTAVVAALVPFPHEDILVASIVSLEEEDVT 897

Query: 118  PVAVTAPPAHLTPAVPLSFSEGLMK----PPPKPTMPS----------RPIAPAPPSTLS 163
              AV+AP     PAV +S  EG         P+ T P+            +A   P   +
Sbjct: 898  AAAVSAPERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAAITQEGMSAVAGFSPEWAA 957

Query: 164  LPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRS-----NA 218
            L   VP    +T E   P+    P  T+   +   +    + T     S   +       
Sbjct: 958  LAITVP----ITEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEP 1013

Query: 219  PGPPLHIGASHLPRGAAAAA------VMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQP 272
              P   +     P   AAA          ++ V T   PTS  P AA   P         
Sbjct: 1014 TSPAAAVPTPEEPTSPAAAVPPPEEPTSPAAAVPTPEEPTS--PAAAVPTP--------- 1062

Query: 273  IQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHA-------TDSALSRPTLSIQHP 325
                 P + + A+P     T  A    +P   T+ A A       T  A + PT   + P
Sbjct: 1063 ---EEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPT--PEEP 1117

Query: 326  PSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILA 385
             S A ++  P +       +  P  PA   P       +     +  TP  +A+ A  + 
Sbjct: 1118 ASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVP 1177

Query: 386  TNTIPSATTAGSVSHTQAPTSTIVTMTVPS--------HSSHATAVTTSNIP--VAKVVP 435
            T    SA+ A  V+  + PTS   ++  P+         +S A +V TS  P  +A  V 
Sbjct: 1178 T-PAESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVS 1236

Query: 436  QQITHTSPR----------------IQPDYPAERSSLIPISGHRASPNPVAMETRSDNRP 479
                 TSP                 + P+  +  ++ +P     ASP            P
Sbjct: 1237 NPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASP 1296

Query: 480  SVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAP 524
            +  V      PT   +A P AA   TP   ++      P+   +P
Sbjct: 1297 AAAV------PTPEVAAIP-AASVPTPEVPAIPAAAVPPMEEVSP 1334



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 82/330 (24%), Positives = 119/330 (36%), Gaps = 47/330 (14%)

Query: 573  PAPIGTPGIQP-APLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVA 631
            PAP GT  +    P   + I  A+ ++ +           P+     +  V     T   
Sbjct: 864  PAPEGTAVVAALVPFPHEDILVASIVSLEEEDVTAAAVSAPERATVPAVTVSVPEGTAAV 923

Query: 632  NPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILR-KKPAT--DGAK-----PK 683
              +S+P   APA    +     SA       G SP  + L    P T  DG       P 
Sbjct: 924  AAVSSPEETAPAVAAAITQEGMSA-----VAGFSPEWAALAITVPITEEDGTPEGPVTPA 978

Query: 684  SEIHVSMATPVTVSMETVSNQNNDQPTIAVP-------PTAQQPPPTIPTMIAAASPPSQ 736
            + +H     P T ++   + +    P  AVP       P A  P P  PT  AAA PP +
Sbjct: 979  TTVHAP-EEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPPPE 1037

Query: 737  PAVALSTIPGAVPITP--PITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIM 794
                  T P A   TP  P +  AA P P      + ++V  P  P         P +  
Sbjct: 1038 EP----TSPAAAVPTPEEPTSPAAAVPTPEEPTSPA-AAVPTPEEPTSPAAAVPTPEEPT 1092

Query: 795  RPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPR------KKPRKQQHVISTEEG 848
             P +AVP     T SP+ A       +PT + P  ASP       ++P      + T E 
Sbjct: 1093 SPAAAVPTPEEPT-SPAAA-------VPTPEEP--ASPAAAVPTPEEPASPAAAVPTPEE 1142

Query: 849  DMMETNS--TDDEKSTAKSLLVKAEKRKSP 876
                  +  T +E ++A   +   E+  SP
Sbjct: 1143 PAFPAPAVPTPEESASAAVAVPTPEESASP 1172


>gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens]
          Length = 2382

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 162/676 (23%), Positives = 254/676 (37%), Gaps = 115/676 (17%)

Query: 239  VMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPI-QSRPPVTTSNAIPPAVVATVSATR 297
            + +SS    +  PTS L     +  A +  I  P+ +SR  +  S   P  +  TV+A+ 
Sbjct: 1231 IPASSMPQQIGIPTSSLTQVVHS--AGRRFIVSPVPESR--LRESKVFPSEITDTVAAST 1286

Query: 298  AQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSH--PALGT 355
            AQSP +  +  H+  S      LS+Q    A   ++R   +    T     SH  P    
Sbjct: 1287 AQSPGMNLS--HSASS------LSLQQ---AFSELRRAQMTEGPNTAPPNFSHTGPTFPV 1335

Query: 356  PKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSV-SHTQAPTST----IVT 410
                L ++A       G P  AA  AP+ AT++ P+  +   + S    PT      + T
Sbjct: 1336 VPPFLSSIA-------GVPTTAAATAPVPATSSPPNDISTSVIQSEVTVPTEEGIAGVAT 1388

Query: 411  MT----------VPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPIS 460
             T           P   S   +   S+I +  VV   I+ TSP +Q   P   S ++ +S
Sbjct: 1389 STGVVTSGGLPIPPVSESPVLSSVVSSITIPAVV--SISTTSPSLQ--VPTSTSEIV-VS 1443

Query: 461  GHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVS 520
                 P+     T +    S         P    S     + T     +SVST   +P +
Sbjct: 1444 STALYPSVTVSATSASAGGSTATPGPK--PPAVVSQQAAGSTTVGATLTSVSTTTSFPST 1501

Query: 521  AQAPNSAITAQTGVG-VASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTP 579
            A   +  +++ T    +A TV ++   L     S    +     AP S+     A + + 
Sbjct: 1502 ASQLSIQLSSSTSTPTLAETVVVSAHSLDKTSHSSTTGLAFSLSAPSSSSS-PGAGVSSY 1560

Query: 580  GIQPA---PLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISN 636
              QP    PL    + ++TPI              PQ  G TS  +L    +I   P+  
Sbjct: 1561 ISQPGGLHPLVIPSVIASTPI-------------LPQAAGPTSTPLLPQVPSIP--PLVQ 1605

Query: 637  PFSAAPAAT-TVVQTHSQSA------STNAPAQGSSPRPSILRKKPATDGAKPK------ 683
            P +  PA   T++ +  Q A       T+ P   S  +P    K P  D  K        
Sbjct: 1606 PVANVPAVQQTLIHSQPQPALLPNQPHTHCPEVDSDTQP----KAPGIDDIKTLEEKLRS 1661

Query: 684  --SEIHVSMATPVTVSMETV----SNQNNDQPTIAVPPTAQQ--------PPPTIP--TM 727
              SE   S A   +VS+ET     S      PT AV P+           PP  +P  T+
Sbjct: 1662 LFSEHSSSGAQHASVSLETSLVIESTVTPGIPTTAVAPSKLLTSTTSTCLPPTNLPLGTV 1721

Query: 728  IAAASP---PSQPAVALSTI-----PGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPV 779
                +P   P Q +  +ST      PG  P  PP+T     P  +    G+L S   PP 
Sbjct: 1722 ALPVTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVGTELPAGTLPSEQLPPF 1781

Query: 780  PEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQ 839
            P   + +  +P++       +      T+SP +  + + +  P S   P A      + Q
Sbjct: 1782 PGPSLTQSQQPLE------DLDAQLRRTLSPEMITVTSAVG-PVSMAAPTAITEAGTQPQ 1834

Query: 840  QHVISTEEGDMMETNS 855
            + V   +EG ++ T+S
Sbjct: 1835 KGVSQVKEGPVLATSS 1850



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 185/914 (20%), Positives = 315/914 (34%), Gaps = 107/914 (11%)

Query: 16   GAGGGRRLQVEMSSQQFPRLG-----APSTGL--SQAPSQI-ANSGSAGLINPAATVNDE 67
            G G     +  +SSQQ    G     A STG      PS + A S   G+  P++    +
Sbjct: 658  GQGSSVFTESRVSSQQTVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVAQGQ 717

Query: 68   SGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAH 127
            S      S+   +SSS  +Q  +++Q   + +  P  Q +    +  S +  A TA P  
Sbjct: 718  SQGQPSSSSLTGVSSSQPIQHPQQQQG--IQQTAPPQQTVQYSLSQTSTSSEATTAQPVS 775

Query: 128  L--TPAVPLSFSEGLMKP--PPKPTMPSRPIAPAPPSTLSLPPKVPGQ-VTVTMESSIPQ 182
                P V    S G   P   P PT+   P  P       +P       + V      P 
Sbjct: 776  QPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQPSVVPVHSGAHFLPVGQPLPTPL 835

Query: 183  ASAIPVATISGQQGHPSNLHHIMTTNVQMSII----RSNAPGPPLHIGASHLPRGAAAAA 238
                PV+ I      P +  H+ T     S +     +    P L + +S         +
Sbjct: 836  LPQYPVSQI------PISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPGVS 889

Query: 239  VMSSSKVTTVLRPTSQLPNAA---TAQPAVQHI---IHQPIQSRPPVTTSNAI----PPA 288
             +  S++ T+L+P +QLP+       QPAVQ +    +    +  P+++ + +    PP 
Sbjct: 890  TVVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAAEVPLSSGDVLYQGFPPR 949

Query: 289  VVATV--SATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRIT 346
            +       +  A S  + +   H+T  +   PT  +  P      +Q   +S  +     
Sbjct: 950  LPPQYPGDSNIAPSSNVASVCIHSTVLSPPMPTEVLATPGYFPTVVQPYVESNLLVPMGG 1009

Query: 347  LPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTS 406
            +     +  P   L   AQ    S+   V  +T      +   P+   A  V+ TQA   
Sbjct: 1010 VGGQVQVSQPGGSL---AQAPTTSSQQAVLESTQG---VSQVAPAEPVA--VAQTQATQP 1061

Query: 407  TIVTMTVPS-HSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRAS 465
            T +  +V S HS  A+ ++  N  V     +    T+ R        R S+   S H  +
Sbjct: 1062 TTLASSVDSAHSDVASGMSDGNENVPSSSGRHEGRTTKRHY------RKSVRSRSRHEKT 1115

Query: 466  PNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPN 525
              P        N+    V+ Q            L  H    +T       ++ +    P 
Sbjct: 1116 SRPKLRILNVSNKGDRVVECQ------------LETHNRKMVTF------KFDLDGDNPE 1157

Query: 526  SAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGI--QPAPISTQGIQPAPIGTPGIQP 583
               T             N   L     S    ++ I  +   + ++ +   P G  G++ 
Sbjct: 1158 EIATIMVN---------NDFILAIERESFVDQVREIIEKADEMLSEDVSVEPEGDQGLES 1208

Query: 584  AP-LGTQGIHSATPINTQGLQPAPMGTQQPQ---PEGKTSAVVLADGATIVANPI----- 634
                   G   +  +  +  QP P  +   Q   P    + VV + G   + +P+     
Sbjct: 1209 LQGKDDYGFSGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQVVHSAGRRFIVSPVPESRL 1268

Query: 635  -SNPFSAAPAATTVVQTHSQSASTNAPAQGSS----PRPSILRKKPATDGAK--PKSEIH 687
              +    +    TV  + +QS   N     SS       S LR+   T+G    P +  H
Sbjct: 1269 RESKVFPSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQMTEGPNTAPPNFSH 1328

Query: 688  VSMATPVTVS-METVSNQNNDQPTIAVPPTAQQPPPTIPTMI--AAASPPSQPAVALSTI 744
                 PV    + +++         A  P    PP  I T +  +  + P++  +A    
Sbjct: 1329 TGPTFPVVPPFLSSIAGVPTTAAATAPVPATSSPPNDISTSVIQSEVTVPTEEGIA---- 1384

Query: 745  PGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLA 804
               V  +  + T    P P V+    LSSV+        V        +  P S    + 
Sbjct: 1385 --GVATSTGVVTSGGLPIPPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPTSTSEIVV 1442

Query: 805  TNT-VSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTA 863
            ++T + PS+ + A + S   S   PG  P     +Q    +T    +   ++T    STA
Sbjct: 1443 SSTALYPSVTVSATSASAGGSTATPGPKPPAVVSQQAAGSTTVGATLTSVSTTTSFPSTA 1502

Query: 864  KSLLVKAEKRKSPP 877
              L ++     S P
Sbjct: 1503 SQLSIQLSSSTSTP 1516



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 173/778 (22%), Positives = 275/778 (35%), Gaps = 165/778 (21%)

Query: 16   GAGGGRRLQVEM-----SSQQFPRLGAPSTGLSQAPSQIANSGSAGLINPAATVNDESGR 70
            G  G ++L+ E      +S    ++G P++ L+Q    + ++G   +++P   V +   R
Sbjct: 1216 GFSGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQV---VHSAGRRFIVSP---VPESRLR 1269

Query: 71   DSEVSARE------------------HMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHH- 111
            +S+V   E                  H +SS SLQ    +     +   P     +  H 
Sbjct: 1270 ESKVFPSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQMTEGPNTAPPNFSHT 1329

Query: 112  ------------AVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRP-IAPAP 158
                        ++A     A    P   T + P   S  +++   + T+P+   IA   
Sbjct: 1330 GPTFPVVPPFLSSIAGVPTTAAATAPVPATSSPPNDISTSVIQS--EVTVPTEEGIAGVA 1387

Query: 159  PST-------LSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQM 211
             ST       L +PP     V  ++ SSI   + + ++T S     P++   I       
Sbjct: 1388 TSTGVVTSGGLPIPPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPTSTSEI------- 1440

Query: 212  SIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQ 271
             ++ S A  P + + A                        TS     +TA P        
Sbjct: 1441 -VVSSTALYPSVTVSA------------------------TSASAGGSTATPG------- 1468

Query: 272  PIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAIS 331
                +PP   S     A   TV AT   + V TTT+  +T S LS    S    P+ A +
Sbjct: 1469 ---PKPPAVVSQ--QAAGSTTVGAT--LTSVSTTTSFPSTASQLSIQLSSSTSTPTLAET 1521

Query: 332  IQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAP-ILATNTIP 390
            +   A S D T      SH +  T        A  +  S G  V++    P  L    IP
Sbjct: 1522 VVVSAHSLDKT------SHSS--TTGLAFSLSAPSSSSSPGAGVSSYISQPGGLHPLVIP 1573

Query: 391  SATTAGSV-SHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDY 449
            S   +  +      PTST +   VPS       V  +N+P    V Q + H+ P  QP  
Sbjct: 1574 SVIASTPILPQAAGPTSTPLLPQVPSIPPLVQPV--ANVP---AVQQTLIHSQP--QP-- 1624

Query: 450  PAERSSLIPISGHRASPNPVAMETRSDNRPSVP------VQFQYFLPTYPPSAYPLAAHT 503
                 +L+P   H   P     E  SD +P  P         +     +   +   A H 
Sbjct: 1625 -----ALLPNQPHTHCP-----EVDSDTQPKAPGIDDIKTLEEKLRSLFSEHSSSGAQHA 1674

Query: 504  YTPITSSV---STIRQ-YPVSAQAPNSAITAQTGVGVAST-VHLNPMQLMTVDASHARHI 558
               + +S+   ST+    P +A AP+  +T+ T   +  T + L  + L          +
Sbjct: 1675 SVSLETSLVIESTVTPGIPTTAVAPSKLLTSTTSTCLPPTNLPLGTVALPVTPVVTPGQV 1734

Query: 559  QGIQPAPISTQGIQPAPIGTPGIQP-------APLGTQGIHSATPINTQGLQPAPMGTQQ 611
                P   +T G++P   GT   +P        P+GT+      P       P P  TQ 
Sbjct: 1735 S--TPVSTTTSGVKP---GTAPSKPPLTKAPVLPVGTELPAGTLPSEQLPPFPGPSLTQS 1789

Query: 612  PQPEGKTSAVV---LADGATIVANPISNPFSAAPAATTVVQTHSQ---SASTNAPAQGSS 665
             QP     A +   L+     V + +     AAP A T   T  Q   S     P   +S
Sbjct: 1790 QQPLEDLDAQLRRTLSPEMITVTSAVGPVSMAAPTAITEAGTQPQKGVSQVKEGPVLATS 1849

Query: 666  PRPSILRK-----KPATDGA----KPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVP 714
                + +        A DGA    K KSE   S+    + S  +V + ++ + T+  P
Sbjct: 1850 SGAGVFKMGRFQVSVAADGAQKEGKNKSEDAKSVHFESSTSESSVLSSSSPESTLVKP 1907



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 99/449 (22%), Positives = 161/449 (35%), Gaps = 71/449 (15%)

Query: 322 IQHPPSAAISIQRPA-QSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATV 380
           I+  PSA+  I   +  S  V+T++  P  P     +Q  +     ++ S GT  +    
Sbjct: 603 IKQLPSASTGIPTASTTSASVSTQVE-PEEPEADQHQQLQYQQPSISVLSDGTVDSGQGS 661

Query: 381 APILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITH 440
           +    +      T +    H QA +    T TVP H    + V   + P     P  +  
Sbjct: 662 SVFTESRVSSQQTVSYGSQHEQAHS----TGTVPGHI--PSTVQAQSQPHGVYPPSSVAQ 715

Query: 441 TSPRIQPDYPAERSSLIPISGHRASPNPVAME-TRSDNRPSVPVQF---QYFLPTYPPSA 496
              + QP      SSL  +S  +   +P   +  +    P   VQ+   Q    +   +A
Sbjct: 716 GQSQGQP----SSSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTA 771

Query: 497 YPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHAR 556
            P++      +   VS  +Q PVS   P   I  +  + VA+   + P+       +H  
Sbjct: 772 QPVSQPQAPQVLPQVSAGKQLPVSQPVP--TIQGEPQIPVATQPSVVPVH----SGAHFL 825

Query: 557 HIQGIQPAPISTQ-GIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPE 615
            +    P P+  Q  +   PI TP +  A  G     S+ PI          G  QP   
Sbjct: 826 PVGQPLPTPLLPQYPVSQIPISTPHVSTAQTG----FSSLPITMAA------GITQP--- 872

Query: 616 GKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKP 675
                + LA  AT          +A P  +TVV                S  P++L  +P
Sbjct: 873 ----LLTLASSATT---------AAIPGVSTVV---------------PSQLPTLL--QP 902

Query: 676 ATDGAKPKSEIHVSMATPVTVSMETVSN--QNNDQPTIAVPPTAQQPPPTIPTMIAAASP 733
            T   +  S++H  +  P   SM   +N  Q  + P  +     Q  PP +P      S 
Sbjct: 903 VT---QLPSQVHPQLLQPAVQSMGIPANLGQAAEVPLSSGDVLYQGFPPRLPPQYPGDSN 959

Query: 734 PSQPAVALSTIPGAVPITPPITTIAAAPP 762
            +  +   S    +  ++PP+ T   A P
Sbjct: 960 IAPSSNVASVCIHSTVLSPPMPTEVLATP 988



 Score = 32.0 bits (71), Expect = 3.1
 Identities = 44/166 (26%), Positives = 63/166 (37%), Gaps = 34/166 (20%)

Query: 639 SAAPAATTVVQTH-----SQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATP 693
           S   AATT    H     S    +NA A      P  L  +P+   A P+S      A P
Sbjct: 65  SRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSL-PQPSIPAAVPQS------APP 117

Query: 694 VTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAV---ALSTIPGAV-- 748
                ETV+         A    AQQPP        AA+ P + AV   A ST+P +   
Sbjct: 118 EPHREETVT-------ATATSQVAQQPP--------AAAAPGEQAVAGPAPSTVPSSTSK 162

Query: 749 --PITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMD 792
             P++ P    +   PP    G    S   P     + ++++E ++
Sbjct: 163 DRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELE 208


>gi|148612879 polyhomeotic like 3 [Homo sapiens]
          Length = 995

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 150/685 (21%), Positives = 249/685 (36%), Gaps = 112/685 (16%)

Query: 288 AVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITL 347
           AV A++S+ R   P  + T +    S++S+ ++++   P+ A  I R   S   +  IT 
Sbjct: 110 AVQASLSSGR---PSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQ 166

Query: 348 PS------HPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHT 401
            +       P L   + Q++  AQ  IF+  T VAA   + I   ++  S++   + +  
Sbjct: 167 QTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQ-SDIPVVSSSSSSSCQSAATQV 225

Query: 402 QAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISG 461
           Q  T     + V S S +    +TS      +   + T TS +I    P+  S+    S 
Sbjct: 226 QNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESP 285

Query: 462 HRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSA 521
              S +     T S ++   P  +       P   + L  H   P+ S  S +  + +  
Sbjct: 286 SLESRSTAVTRTSSIHQLIAPASYS------PIQPHSLIKHQQIPLHSPPSKVSHHQLIL 339

Query: 522 QAPN---SAITAQTGV-GVASTVHLNPMQ-------LMTVDASHARHIQGIQPAPISTQG 570
           Q        IT Q        + H  P+Q            + H   IQ   P+P++   
Sbjct: 340 QQQQQQIQPITLQNSTQDPPPSQHCIPLQNHGLPPAPSNAQSQHCSPIQS-HPSPLTVSP 398

Query: 571 -----------IQPAPIGTPGIQPA-PLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKT 618
                      + P P  +P   P   +  Q +    P+ +  LQP P   Q    + + 
Sbjct: 399 NQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGPNLQQSTANQVQA 458

Query: 619 SA-------VVLADGATIVANPISNPFSAAPAATTVVQTHSQ-SASTNAPAQGSSPRPSI 670
           +A       + L     +   P+      +P    V  +H Q S+  ++P   +SP P +
Sbjct: 459 TAQLNLPSHLPLPASPVVHIGPVQQSALVSPGQQIVSPSHQQYSSLQSSPIPIASP-PQM 517

Query: 671 LRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQN---NDQPTIAVPPTAQQPPPTIPTM 727
               PA     P   +      P  +S   V  QN   +++   A     Q P  T+P  
Sbjct: 518 STSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLP-- 575

Query: 728 IAAASPPSQPAVALSTIPGAVPITPPI-------------------TTIAAAPPP----- 763
                PP   AV L   P A P+ PP+                     +   PPP     
Sbjct: 576 -----PPQTVAVNLQVQPPA-PVDPPVVYQVEDVCEEEMPEESDECVRMDRTPPPPTLSP 629

Query: 764 -SVTVGGS---------LSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLA 813
            ++TVG           L  V  P V  +       P D        PPL    + P+  
Sbjct: 630 AAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPL----LLPAAT 685

Query: 814 LLANNLSMPTS-----DLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLV 868
             +N+ SM +S     + PP A    KP+   HVI   EG +++    +    +  SLL+
Sbjct: 686 TRSNSTSMHSSIPSIENKPPQAI--VKPQILTHVI---EGFVIQ-EGLEPFPVSRSSLLI 739

Query: 869 KAEKRKSPPKEYIDEEGVRYVPVRP 893
           +   +K P    +D + +  V V+P
Sbjct: 740 EQPVKKRP---LLDNQVINSVCVQP 761



 Score = 38.5 bits (88), Expect = 0.033
 Identities = 95/490 (19%), Positives = 180/490 (36%), Gaps = 101/490 (20%)

Query: 33  PRLGAPSTGLSQAPS--QIANSGSAGLINPAATVNDES----GRDSEVSAREHMSSSSSL 86
           P L + ST +++  S  Q+    S   I P + +  +        S+VS  + +     L
Sbjct: 285 PSLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPSKVSHHQLI-----L 339

Query: 87  QSREEKQEPVVVRPYPQVQMLSTH------HAVASA---------TPVAVTAPPAHLTPA 131
           Q ++++ +P+ ++   Q    S H      H +  A         +P+     P  ++P 
Sbjct: 340 QQQQQQIQPITLQNSTQDPPPSQHCIPLQNHGLPPAPSNAQSQHCSPIQSHPSPLTVSPN 399

Query: 132 VPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATI 191
              S  + ++  PP P  PS+                    T+ +    PQA   P   +
Sbjct: 400 QSQSAQQSVVVSPPPPHSPSQ------------------SPTIIIH---PQALIQPHPLV 438

Query: 192 SGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRP 251
           S       NL    T N   +  + N P        SHLP  A+    +   + + ++ P
Sbjct: 439 SSALQPGPNLQQ-STANQVQATAQLNLP--------SHLPLPASPVVHIGPVQQSALVSP 489

Query: 252 TSQLPNAATAQPAVQHIIHQPIQSRPPVTTS--NAIPPAVVATVSATR------------ 297
             Q+ + +  Q +       PI S P ++TS    IPP  + ++ + +            
Sbjct: 490 GQQIVSPSHQQYSSLQSSPIPIASPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVL 549

Query: 298 AQSPVITTTAAHATDSALSRPTLSIQHPPSAAIS--IQRPA--------QSRDVTTR--- 344
            Q+ +++     A ++ +  P  ++  P + A++  +Q PA        Q  DV      
Sbjct: 550 VQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEEMP 609

Query: 345 ------ITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSV 398
                 + +   P   T      T+ +    ++  P+      P +A+ +     +    
Sbjct: 610 EESDECVRMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDP 669

Query: 399 SHTQAPTSTIV----TMTVPSHSSHATAVTTSNIPVAKVV-PQQITHT------SPRIQP 447
           SH   P   ++    T    S S H++  +  N P   +V PQ +TH          ++P
Sbjct: 670 SHVSVPPPPLLLPAATTRSNSTSMHSSIPSIENKPPQAIVKPQILTHVIEGFVIQEGLEP 729

Query: 448 DYPAERSSLI 457
            +P  RSSL+
Sbjct: 730 -FPVSRSSLL 738


>gi|239752594 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 673

 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 162/713 (22%), Positives = 256/713 (35%), Gaps = 103/713 (14%)

Query: 165 PPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLH 224
           P + P + + T   S    +  P  + +   G PS      T ++  +  R++  G P  
Sbjct: 4   PTRTPSRASPTRTPSTASLTGTP--SRASLTGTPS------TASLMGTPSRASLTGTPPR 55

Query: 225 IGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNA 284
             AS     + A+ ++S S+ +     +S L    T  P++  +   P ++    T   A
Sbjct: 56  --ASLKGTTSMASLMVSPSRASLTRMQSSSL---LTRTPSMASLKRMPPRASRTRTLPRA 110

Query: 285 IPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTR 344
                 +T S TR+ S    TT         SR +LS+    +AA+              
Sbjct: 111 SLMRRPSTASLTRSPSRASLTTTP-------SRASLSMTPSTAAAL-------------- 149

Query: 345 ITLPSHPALG-TPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQA 403
            T+PS  +L  TP +   TM   T   T TP  A+       T+     +TA   S T+ 
Sbjct: 150 -TMPSRASLTRTPPRASLTMTPSTASLTRTPPRASPTGMPSRTSPTGMPSTA---SLTKM 205

Query: 404 PTSTIVTMTVPSHSSHAT---AVTTSNIPVAKVVPQQIT----HTSPRIQPDYPAERSSL 456
            ++  +T T+   S   T   A  T + P A +     T     T PR  P     R+SL
Sbjct: 206 DSTASITRTLSRASPTGTPPRASPTGSPPRASLSMMPSTALLIRTPPRASPTGMLSRTSL 265

Query: 457 I-----------PISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYT 505
                       P     ASP            PS        LP   P+   L+  + T
Sbjct: 266 TKMDSTASITRTPSRPSTASPTGTPSRASLSMTPST-ASLMRMLPRASPTGM-LSRTSLT 323

Query: 506 PITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAP 565
            + S+ S  R  P ++     +  + TG    ++    P +     +     + G+  + 
Sbjct: 324 KMDSTASISRTPPRASITRTPSRASPTGKPSTASPTGTPSRASPTGSPSTASLTGLS-ST 382

Query: 566 ISTQGIQP--APIGTPGI-----QPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKT 618
            S  G  P  +P GTP       +P      G+ S T I       +P  T+ P     T
Sbjct: 383 ASPTGTPPRASPTGTPSTASLTRKPPRASPTGMLSRTSITKMDSTASP--TRTPPRASPT 440

Query: 619 SAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPA--------QGSSPRPSI 670
                  G    A+P   P  A+P  T    + + S ST +P          GS  R S+
Sbjct: 441 -------GTPPRASPTGTPSRASPTGTQSTASPTGSPSTASPTGSPSTASPTGSPSRASL 493

Query: 671 LRKKPATDGAKPKSEIHV----SMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPT 726
            R        K +S   +    S A+P T +  T S   +    +A+   ++      P+
Sbjct: 494 TRTPSRASLTKMESTASITRTPSRASP-TWTPSTASPTGSPSTALAMGSPSRAALTRTPS 552

Query: 727 MIAAASPPSQPAVALSTIPGAVPIT-PPITTIAAAPPPSVTVGG--SLSSVLGPPVPEIK 783
             +    PS+ ++   T P    +T  P T +    PPS +  G  S +S  G P   + 
Sbjct: 553 RASLTRTPSRASL---TTPSRASLTRTPSTVLLTRMPPSASPTGMPSRTSPTGMPSSALL 609

Query: 784 VKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKP 836
            K     MD    ++  PP A+ T +P     A+    P    P G  PR  P
Sbjct: 610 TK-----MDSTASITRTPPRASPTETPP---RASPTGTPPRASPTGTPPRASP 654



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 126/533 (23%), Positives = 189/533 (35%), Gaps = 101/533 (18%)

Query: 122 TAPPAHLTPAVPLSFSEGLMKPPPKPT-MPSRPIAPAPPSTLSL---------------- 164
           T P A LT   P + S     P   PT MPSR      PST SL                
Sbjct: 160 TPPRASLT-MTPSTASLTRTPPRASPTGMPSRTSPTGMPSTASLTKMDSTASITRTLSRA 218

Query: 165 -----PPKVP--GQVTVTMESSIPQASAI----PVATISGQQGHPSNLHHIMTTNVQMSI 213
                PP+    G       S +P  + +    P A+ +G     S      T ++  + 
Sbjct: 219 SPTGTPPRASPTGSPPRASLSMMPSTALLIRTPPRASPTGMLSRTSLTKMDSTASITRTP 278

Query: 214 IRSNAPGP---PLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQ----PAVQ 266
            R +   P   P     S  P  A+   ++  +  T +L  TS     +TA     P   
Sbjct: 279 SRPSTASPTGTPSRASLSMTPSTASLMRMLPRASPTGMLSRTSLTKMDSTASISRTPPRA 338

Query: 267 HIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPP 326
            I   P ++ P    S A P    +  S T + S    T  +       + P  S    P
Sbjct: 339 SITRTPSRASPTGKPSTASPTGTPSRASPTGSPSTASLTGLSSTASPTGTPPRASPTGTP 398

Query: 327 SAAISIQRPAQ-------SRDVTTRI-----------------TLPSHPALGTPKQQLHT 362
           S A   ++P +       SR   T++                 T P     GTP +   T
Sbjct: 399 STASLTRKPPRASPTGMLSRTSITKMDSTASPTRTPPRASPTGTPPRASPTGTPSRASPT 458

Query: 363 MAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATA 422
             Q T   TG+P   +T +P  + +T          S T +P+   +T T PS +S    
Sbjct: 459 GTQSTASPTGSP---STASPTGSPST---------ASPTGSPSRASLTRT-PSRASLTKM 505

Query: 423 VTTSNIPVAKVVPQQITHTSPRIQPDY-PAERSSLIPISGHRASPNPV-AMETRSDNRPS 480
            +T++          IT T  R  P + P+  S     S   A  +P  A  TR+ +R S
Sbjct: 506 ESTAS----------ITRTPSRASPTWTPSTASPTGSPSTALAMGSPSRAALTRTPSRAS 555

Query: 481 VPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTI--RQYPVSAQAPNSAITAQTGVGVAS 538
           +         T  PS   L   +   +T + ST+   + P SA +P    +  +  G+ S
Sbjct: 556 L---------TRTPSRASLTTPSRASLTRTPSTVLLTRMPPSA-SPTGMPSRTSPTGMPS 605

Query: 539 TVHLNPM-QLMTVDASHARHIQGIQPAPISTQGIQP--APIGTPGIQPAPLGT 588
           +  L  M    ++  +  R      P   S  G  P  +P GTP  + +P GT
Sbjct: 606 SALLTKMDSTASITRTPPRASPTETPPRASPTGTPPRASPTGTPP-RASPTGT 657


>gi|150378545 POM121 membrane glycoprotein (rat)-like [Homo sapiens]
          Length = 987

 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 166/712 (23%), Positives = 255/712 (35%), Gaps = 122/712 (17%)

Query: 81  SSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGL 140
           S++  L+S ++ Q P  + P P+          A A      +PP   +   PL  S+  
Sbjct: 328 STNPLLESLKKMQTPPSLPPCPES---------AGAATTEALSPPKTPSLLPPLGLSQS- 377

Query: 141 MKPP---PKPTMPSRP------IAPAP---PST-LSLPPKVPGQVTVTMESSIPQASAIP 187
             PP   P P+  S+P      + PAP   P+T    PP +  +     +++   + A  
Sbjct: 378 -GPPGLLPSPSFDSKPPTTLLGLIPAPSMVPATDTKAPPTLQAETATKPQATSAPSPAPK 436

Query: 188 VATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSK--- 244
            + + G Q    +       +    + +     PP        P G +  A   SS    
Sbjct: 437 QSFLFGTQNTSPSSPAAPAASSASPMFKPIFTAPPKSEKEGPTPPGPSVTATAPSSSSLP 496

Query: 245 -VTTVLRPTSQLPNAATAQPAVQHIIHQPI--QSRPPVTTSNAIPPAVVATVSATRAQSP 301
             T+   PT Q P  ++  P     +  P   Q+  P T      P      SAT A +P
Sbjct: 497 TTTSTTAPTFQ-PVFSSMGPPASVPLPAPFFKQTTTPATAPTTTAPLFTGLASATSAVAP 555

Query: 302 VITTTAAHATDSALSRPTLS--IQHPPSAAISIQRPAQSRDVTTRITLPSHPAL-GTPKQ 358
           +  T+A+ +TDSA S+P     I    S+++S          T+  T  S P L G P+ 
Sbjct: 556 I--TSASPSTDSA-SKPAFGFGINSVSSSSVST--------TTSTATAASQPFLFGAPQA 604

Query: 359 QL--HTMAQKTIFSTGTPVAAATVAPILATN-----TIPSATTAGSVSHT----QAPTST 407
                T A  +IF  G P A  T   +   +      +P+AT++ +   +       TS 
Sbjct: 605 SAASFTPAMGSIFQFGKPPALPTTTTVTTFSQSLPTAVPTATSSSAADFSGFGSTLATSA 664

Query: 408 IVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPN 467
             T + P+ +   T+  T NIP        +        P YP       P  G      
Sbjct: 665 PATSSQPTLTFSNTSTPTFNIPFGSSAKSPL--------PSYPGANPQ--PAFGAAEGQP 714

Query: 468 PVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSA 527
           P A +      PS    F     T+  SA P  A   TP  +S   I    V A  P   
Sbjct: 715 PGAAKPALT--PSFGSSF-----TFGNSAAPAPATAPTPAPASTIKI----VPAHVPT-- 761

Query: 528 ITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLG 587
                           P+Q     A+H+    G++    +T     AP  +   QPA  G
Sbjct: 762 ----------------PIQPTFGGATHSAF--GLK----ATASAFGAPASS---QPAFGG 796

Query: 588 TQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTV 647
           +  + S     + G       T Q    G +S+V    G+T   +P +   SAAPA +  
Sbjct: 797 STAVFSFGAATSSGFG----ATTQTASSGSSSSVF---GST-TPSPFTFGGSAAPAGSGS 848

Query: 648 ----VQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSN 703
               V T   SA+T A + G+    S     P T G    +      +TP   ++ + + 
Sbjct: 849 FGINVATPGSSATTGAFSFGAGQSGSTATSTPFTGGLGQNALGTTGQSTPFAFNVGSTTE 908

Query: 704 QNNDQPTIAVPPTAQQ-PPPTIPT-----MIAAASPPSQPAVALSTIPGAVP 749
                   A P   Q  P P + T        A+S P+Q  V +     A P
Sbjct: 909 SKPVFGGTATPTFGQNTPAPGVGTSGSSLSFGASSAPAQGFVGVGPFGSAAP 960



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 134/609 (22%), Positives = 205/609 (33%), Gaps = 100/609 (16%)

Query: 241 SSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQS 300
           SSS  ++     SQ P     +   + + H    S P            +A    ++ + 
Sbjct: 168 SSSPFSSPASSRSQTPERPAKKIREEELCHHSSSSTP------------LAADKESQGEK 215

Query: 301 PVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALG------ 354
              TT       ++ S P  S Q      +   R  +      ++TLP  P LG      
Sbjct: 216 AADTTPRKKQNSNSQSTPGSSGQRKRKVQLLPSRRGE------QLTLPPPPQLGYSITAE 269

Query: 355 ----TPKQQLHTMAQKTIFSTGTPVAAATVAPILA----TNTIPSATTAGSVSHTQAPTS 406
                 K  L    Q     +     + T  P       T T+P+A TA        PTS
Sbjct: 270 DLDLEKKASLQWFNQALEDKSDAASNSVTETPPTTQPSFTFTLPAAATASP------PTS 323

Query: 407 TIVTMTVPSHSSHATAVTTSNIPVAKVVPQQI-THTSPRIQPDYPAERSSLIPISGHRAS 465
            +   T P   S     T  ++P     P+     T+  + P  P   S L P+   ++ 
Sbjct: 324 LLAPSTNPLLESLKKMQTPPSLPPC---PESAGAATTEALSP--PKTPSLLPPLGLSQSG 378

Query: 466 PNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPN 525
           P  +      D++P  P      +P   PS  P A  T  P T    T  + P +  AP+
Sbjct: 379 PPGLLPSPSFDSKP--PTTLLGLIPA--PSMVP-ATDTKAPPTLQAETATK-PQATSAPS 432

Query: 526 SAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAP 585
            A       G  +T   +P       AS     + I  AP  ++   P P G     P+ 
Sbjct: 433 PAPKQSFLFGTQNTSPSSPAAPAASSASPM--FKPIFTAPPKSEKEGPTPPG-----PSV 485

Query: 586 LGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAAT 645
             T    S+ P  T    P    T QP         V +      + P+  PF       
Sbjct: 486 TATAPSSSSLPTTTSTTAP----TFQP---------VFSSMGPPASVPLPAPFFKQTTTP 532

Query: 646 TVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGA-KPKSEIHVSMATPVTVSMETVSNQ 704
               T +    T   +  S+  P I    P+TD A KP     ++  +  +VS  T +  
Sbjct: 533 ATAPTTTAPLFTGLASATSAVAP-ITSASPSTDSASKPAFGFGINSVSSSSVSTTTSTAT 591

Query: 705 NNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPS 764
              QP +   P A           AA+  P+  ++     P A+P T  +TT + + P +
Sbjct: 592 AASQPFLFGAPQAS----------AASFTPAMGSIFQFGKPPALPTTTTVTTFSQSLPTA 641

Query: 765 VTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTS 824
           V    S S+                  D     S +   A  T S    L  +N S PT 
Sbjct: 642 VPTATSSSAA-----------------DFSGFGSTLATSAPAT-SSQPTLTFSNTSTPTF 683

Query: 825 DLPPGASPR 833
           ++P G+S +
Sbjct: 684 NIPFGSSAK 692



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 83/389 (21%), Positives = 136/389 (34%), Gaps = 94/389 (24%)

Query: 470 AMETRSDNRPSVPVQFQYFLPTYPPSAYP--LAAHTYTPITSSVSTIRQYPVSAQAPNSA 527
           A  + ++  P+    F + LP    ++ P  L A +  P+  S+  ++  P     P SA
Sbjct: 293 ASNSVTETPPTTQPSFTFTLPAAATASPPTSLLAPSTNPLLESLKKMQTPPSLPPCPESA 352

Query: 528 ITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLG 587
                  G A+T  L+P +                P+ +   G+  +  G PG+ P+P  
Sbjct: 353 -------GAATTEALSPPKT---------------PSLLPPLGLSQS--GPPGLLPSP-- 386

Query: 588 TQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTV 647
                S  P    GL PAP  +  P  + K    + A+ AT                   
Sbjct: 387 --SFDSKPPTTLLGLIPAP--SMVPATDTKAPPTLQAETAT------------------- 423

Query: 648 VQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNND 707
                +  +T+AP+   +P+ S L     T  + P +    S A+P+             
Sbjct: 424 -----KPQATSAPSP--APKQSFLFGTQNTSPSSPAAPA-ASSASPMF------------ 463

Query: 708 QPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTV 767
           +P    PP +++  PT P     A+ PS  ++  +T   A    P  +++   PP SV  
Sbjct: 464 KPIFTAPPKSEKEGPTPPGPSVTATAPSSSSLPTTTSTTAPTFQPVFSSM--GPPASV-- 519

Query: 768 GGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLP 827
                     P+P    K+   P        A  P  T  +   LA  A +   P +   
Sbjct: 520 ----------PLPAPFFKQTTTP--------ATAPTTTAPLFTGLA-SATSAVAPITSAS 560

Query: 828 PGASPRKKPRKQQHVISTEEGDMMETNST 856
           P      KP     + S     +  T ST
Sbjct: 561 PSTDSASKPAFGFGINSVSSSSVSTTTST 589


>gi|171460948 TSC22 domain family, member 1 isoform 1 [Homo sapiens]
          Length = 1073

 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 183/899 (20%), Positives = 318/899 (35%), Gaps = 115/899 (12%)

Query: 9   AGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINPAATVNDES 68
           A  + A G G G       SS+ FP    PS  L Q P   A+S S     P  ++N  S
Sbjct: 38  ASALNAAGTGVGSNAT---SSEDFP---PPS--LLQPPPPAASSTSGPQPPPPQSLNLLS 89

Query: 69  GRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHL 128
               +    + ++   +   ++   +   V P      +S+++++A  T        +H 
Sbjct: 90  QAQLQA---QPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHT 146

Query: 129 TPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLS--LPPKVPGQVTVTMES-------S 179
                LS SE L     + T    P   +   TL+     + PG V+             
Sbjct: 147 ED---LSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPH 203

Query: 180 IPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAV 239
           +PQ + +    I+G   HP +LHH    +    +   +     + + ++ +  G  ++ V
Sbjct: 204 LPQQNVV----INGN-AHPHHLHHHHQIHHGHHLQHGHHHPSHVAVASASITGGPPSSPV 258

Query: 240 M------SSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATV 293
                   SS   T + PTS + ++ +    + ++       R P TT      +V  T 
Sbjct: 259 SRKLSTTGSSDSITPVAPTSAVSSSGSPASVMTNM-------RAPSTTGGIGINSVTGTS 311

Query: 294 SATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPAL 353
           +        + +   + T S L    +S  + PSAA     P  +  V   I        
Sbjct: 312 TVNNVNITAVGSFNPNVTSSMLGNVNISTSNIPSAAGVSVGPGVTSGVNVNILSGMGNGT 371

Query: 354 GTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTV 413
            +    + ++       TG  V++    P + T+         S    +    T      
Sbjct: 372 ISSSAAVSSVPNAAAGMTGGSVSSQQQQPTVNTSRFRVVKLDSSSEPFKKGRWTCTEFYE 431

Query: 414 PSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMET 473
             ++  AT     N  V  V    I  TS R      +  SS+  +S +  S     M  
Sbjct: 432 KENAVPATEGVLINKVVETVKQNPIEVTSERESTSGSSVSSSVSTLSHYTESVGSGEM-- 489

Query: 474 RSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTG 533
                P+V VQ Q                   P    V T++Q    +  P S       
Sbjct: 490 ---GAPTVVVQQQQ---------QQQQQQQQQPALQGV-TLQQMDFGSTGPQSIPAVSIP 536

Query: 534 VGVASTVHLNPMQLMTVDASHARHIQGIQPAPI-----STQGIQPAPIGTPGIQPAPLGT 588
             ++ +  ++ +QL + + S+ +  QG+QP P+     +  GIQP+P+   G+  A LG 
Sbjct: 537 QSISQS-QISQVQLQSQELSYQQK-QGLQPVPLQATMSAATGIQPSPVNVVGVTSA-LGQ 593

Query: 589 QGIHS------------ATPINT-----------QGLQPAPMGTQQPQPEGKTSAVVLAD 625
           Q   S            A P+ T           Q  Q  PM + Q  P    S      
Sbjct: 594 QPSISSLAQPQLPYSQAAPPVQTPLPGAPPPQQLQYGQQQPMVSTQMAPGHVKSVTQNPA 653

Query: 626 GATIVANPI-------SNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATD 678
              +   PI         P SA   A T V   +Q      P Q     P+ +  +PA  
Sbjct: 654 SEYVQQQPILQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPVQ-----PTAVPAQPAGA 708

Query: 679 GAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPA 738
             +P  +   +++   T S      Q  + PT    P+ Q P    P++I   +PPS   
Sbjct: 709 SVQPVGQAPAAVSAVPTGSQIANIGQQANIPTAVQQPSTQVP----PSVIQQGAPPSS-- 762

Query: 739 VALSTIPGAVP--ITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRP 796
                +P A    I   + T A + P  + +    S +  PP P     + VEP+     
Sbjct: 763 ---QVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSLLTVPPQP-----QGVEPVAQGIV 814

Query: 797 VSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNS 855
              +P +++   + S+++ +   S   S +P   +    P+      +T+ G+++++ S
Sbjct: 815 SQQLPAVSSLPSASSISVTSQVSSTGPSGMPSAPTNLVPPQNIAQTPATQNGNLVQSVS 873



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 68/315 (21%), Positives = 109/315 (34%), Gaps = 48/315 (15%)

Query: 29  SQQFPRLGAPSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVS---AREHMSSSSS 85
           SQ  P +  P  G +  P Q+      G   P  +     G    V+   A E++     
Sbjct: 608 SQAAPPVQTPLPG-APPPQQL----QYGQQQPMVSTQMAPGHVKSVTQNPASEYVQQQPI 662

Query: 86  LQSREEKQEP----------VVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLS 135
           LQ+     +P          V+    PQ   L        A P   +  P    PA   +
Sbjct: 663 LQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPVQPTAVPAQPAGASVQPVGQAPAAVSA 722

Query: 136 FSEGLM--------KPPPKPTMPSRPIAP------APPSTLSLPPKVPGQVTVTMESSIP 181
              G            P     PS  + P      APPS+  +PP   G +   +++S P
Sbjct: 723 VPTGSQIANIGQQANIPTAVQQPSTQVPPSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAP 782

Query: 182 QASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMS 241
              ++P   +   Q        ++T   Q   +   A G    I +  LP  ++  +  S
Sbjct: 783 ---SLPQQLVIASQSS------LLTVPPQPQGVEPVAQG----IVSQQLPAVSSLPSA-S 828

Query: 242 SSKVTTVLRPT--SQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQ 299
           S  VT+ +  T  S +P+A T     Q+I   P      +  S + PP +    +   AQ
Sbjct: 829 SISVTSQVSSTGPSGMPSAPTNLVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQ 888

Query: 300 SPVITTTAAHATDSA 314
              +++T   A   A
Sbjct: 889 QIPLSSTQFSAQSLA 903


>gi|169205253 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 3859

 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 180/821 (21%), Positives = 278/821 (33%), Gaps = 127/821 (15%)

Query: 95   PVVVRPYPQVQMLSTHHAVASATPV---AVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPS 151
            PV     P V +      V S T     AV   PA  +P VP++ ++G + P      P 
Sbjct: 589  PVTPADSPVVPVTPADSPVLSVTLADSPAVPVTPAD-SPVVPVTPADGPVVPVASADSPF 647

Query: 152  RPIAPAPPSTLSLPPKVPGQVTVTMESS--IPQASA----IPVATISGQ------QGHPS 199
             P+ PA    +S+ P     + VT   S  +P  SA    IPV T  G+       G P 
Sbjct: 648  VPVTPADDPIVSVTPAESPAIPVTQADSPVVPVTSADRPVIPVTTADGRIVPVTAAGDPI 707

Query: 200  NLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAA 259
                       + +  ++ PG P+         G       + S    V  P   +    
Sbjct: 708  -----------VPVTPADTPGSPVTSA-----DGPVVPVTSADSPFVPVTPPDGPVVPVT 751

Query: 260  TAQPAVQHIIHQPIQSR--PPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSR 317
            +A   V      P+ S   P V  ++A  P  VA VS+  A  PV+  T A     A+  
Sbjct: 752  SADGPV-----APVSSADGPVVPVTSADGP--VAPVSS--ADGPVVPVTPADTNGPAV-- 800

Query: 318  PTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPA---------LGTPKQQLHTMAQKTI 368
            P  S   P    I    P           +P  PA           +P   +       +
Sbjct: 801  PVTSADSPFVPVIPADSPVVPVTPADDPIVPVTPADSSFVPVISADSPFVPVIPADGPVV 860

Query: 369  FSTGTPVAAATVAPI-------LATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHAT 421
              + T V    V P+        A  T+     A S      P   +V    P+    A 
Sbjct: 861  VDSSTDVLVVPVFPVNCILVPAFADETVVPLNPADSPVIPVTPPDDLVVPVTPTDCPVA- 919

Query: 422  AVTTSNIPVAKVVP-----QQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSD 476
             VT+++ PV  V P       +T     + P  PA+   ++P++    + +PV   T +D
Sbjct: 920  PVTSADCPVVPVTPADSPADPVTAADGPVVPFTPAD-DPIVPVT---PADSPVVSVTPAD 975

Query: 477  NRPSVPVQF--QYFLPTYPPS----AYPLAAHTYTPITSSVSTIRQYPV-SAQAPNSAIT 529
              P VPV      F+P  P      +   A     P+T + S +   PV SA  P S +T
Sbjct: 976  G-PVVPVASADSPFVPVTPADDPIVSVTPAESPAIPVTQADSPV--VPVTSADRPVSPVT 1032

Query: 530  AQTGVGVASTVHLNPMQLMT-VDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGT 588
               G  V  T   +P+  +T  D   +       P    T    P    TP   P    T
Sbjct: 1033 TADGRIVPVTAAGDPIVPVTPADTPGSPVTSADGPVVPVTSADSPFVPVTPPDGPVVPVT 1092

Query: 589  QGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVV 648
                   P+++      P+       +G  + V  ADG  +   P  +PF     A   +
Sbjct: 1093 SADGPVAPVSSADGPVVPV----TSADGPVAPVSSADGPVVPVTPADSPFIPVTTADDPI 1148

Query: 649  QTHSQSAS-------TNAPAQGSSPRPS-ILRKKPATDGAKPKSEIHVSMATPVTVSMET 700
               + + S        ++P    +P  S ++   PA     P S         +      
Sbjct: 1149 VPVTPADSPVLSVTLADSPVVPVTPADSPVIPVPPANGPVVPVSSADSPFVPVIPADGLV 1208

Query: 701  VSNQNND------QPT--IAVPPTAQQPPPTI---PTMIAAASPPSQPAVALSTIPG-AV 748
            V + + D       PT  I VP  A  P  ++    + +   +P   P V +++     V
Sbjct: 1209 VLDSSTDVLVVPVSPTDGILVPDLADDPVVSVTIADSPVIPVTPADSPVVPVTSADSPVV 1268

Query: 749  PITP------------PITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPM----- 791
            P+TP            P+ ++  A  P V V    S+   P +P       V P+     
Sbjct: 1269 PVTPADSPVILVTPVGPVVSVTTADGPVVLV----STADSPVIPVTSADSPVVPVTPADG 1324

Query: 792  DIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASP 832
             ++   SA  P    T +    +       P   + P  SP
Sbjct: 1325 PVVPVTSADSPFVPVTPADDPIVPVTPADSPIVSVTPAESP 1365



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 151/723 (20%), Positives = 247/723 (34%), Gaps = 111/723 (15%)

Query: 123  APPAHLTPA----VPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTME- 177
            +P   +TPA    VP++ ++G + P     +P  P+ PA      + P     V+V    
Sbjct: 1593 SPVIPVTPADSTVVPVTLADGPVVPVTSVDIPVVPVTPANGPVAPVTPVDDPVVSVNPAD 1652

Query: 178  -SSIPQASA-IPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAA 235
             S +P  SA  PV  ++   G              + +  + A  P + +  +  P    
Sbjct: 1653 GSVVPVTSADCPVVPVTPADG--------------LVVPVTPADSPIVPVTPADSPVVLV 1698

Query: 236  AAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRP----PVTTSNAIPPAVVA 291
             +A      VT    P   + +A T  P        P+ S      PVT+++++P     
Sbjct: 1699 TSADSPVIPVTPADSPVVPVTSADTDSPG------SPVTSADGPVVPVTSADSLP----- 1747

Query: 292  TVSATRAQSPVITTTAAH---ATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLP 348
             V  T A  PV+  T+A    A  S+   P + +    S  + +     + D T  +T  
Sbjct: 1748 -VPVTPADGPVVPVTSADGPVAPVSSADGPVVPVTPADSPVVPV---TTADDPTVPVTPA 1803

Query: 349  SHPALGTPKQQLHTMAQKTIFSTGTPVAAAT----------------------VAPILAT 386
              P +  P      +   +  S   PV  A                       + P LA 
Sbjct: 1804 DSPVVPVPPANGPIVPVTSADSPFVPVIPADGLVVLDSSTDVLVVPVSPTDGILVPDLAD 1863

Query: 387  NTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQ-----ITHT 441
            + + S T A S      P  + V +  P+       VT+ + PV  V P       +T  
Sbjct: 1864 DPVVSVTIADSPVIPVTPADSPVVLVTPADGP-VVPVTSVDNPVVPVTPADNPVIPVTPV 1922

Query: 442  SPRIQPDYPAE------RSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPS 495
               + P  PA+       S+  PI     + +PV   T +D+ P +PV      P  P +
Sbjct: 1923 DDPVVPVTPADDPIVPVTSADSPIVSVTPADSPVFPVTPADS-PVIPVA-SADSPLVPVT 1980

Query: 496  AYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHA 555
               +      P    V  +      A++P   +T      V  T   +P+  +T D+   
Sbjct: 1981 PADMVVVPVIPADGPVIPV----TPAESPAIPVTPTDSPVVPVTSADSPVIPVTADSPFV 2036

Query: 556  RHIQGIQPA----PISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQ 611
                   P     P     +   PI  P + P  L    + S TP N+      P+    
Sbjct: 2037 PVTPADSPVIPVTPPDDLVVPVTPIDCP-VVPVTLVDCPVVSVTPANS------PVDPVT 2089

Query: 612  PQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQ-GSSPRPSI 670
            P  +G    V  AD   I   P  +       A +++ + + + S   P     SP  S+
Sbjct: 2090 PA-DGPVVPVTPADSPVIPVTPADDLIVPVTPADSLIVSVTPADSPVVPVTPADSPVISV 2148

Query: 671  LRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIP--TMI 728
                       P   + V    PVT +         D P I V P      P  P  + +
Sbjct: 2149 ASADSPVVPVTPADTVVV----PVTPA---------DGPVIPVTPAESPAIPVTPADSPV 2195

Query: 729  AAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEV 788
               +P   P V ++     +   PP +       P+ T G  ++S  GP VP       +
Sbjct: 2196 VPVTPADDPVVPVTPADSPIVPVPPASDPVVPVTPADTPGSPVASADGPVVPVTSADSPL 2255

Query: 789  EPM 791
             P+
Sbjct: 2256 VPV 2258



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 171/788 (21%), Positives = 274/788 (34%), Gaps = 120/788 (15%)

Query: 113  VASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQV 172
            V SA    V   PA   P VP++ ++    P      P  P+ PA    +S+ P     +
Sbjct: 1309 VTSADSPVVPVTPAD-GPVVPVTSADSPFVPVTPADDPIVPVTPADSPIVSVTPAESPAI 1367

Query: 173  TVTMESS--IPQASA----IPVATISGQ------------QGHPSNLHHIMTTNVQMSII 214
             VT   S  +P  SA    IP+ T   +               P++      T+    ++
Sbjct: 1368 PVTPADSPVVPVTSADSPLIPLTTAGSRVVPVTPTGDPIVPVTPADTPGSPVTSADGPVV 1427

Query: 215  RSNAPGPPL-HIGASHLPRGAAAAAVMSSSKVTT--------------VLRPTSQLPNAA 259
                 G P+  +  +  P     +A      VTT              V+  TS      
Sbjct: 1428 PVTPAGDPIVPVTPADTPGSPVTSADGPVVPVTTPDGPLVPVSPPDGPVVPVTSADGPVV 1487

Query: 260  TAQPAVQHIIHQPIQSRP--PVTTSNA----IPPAVVATVSATRAQSPVITTTAAHA--- 310
               PA    I       P  PVT +++    + PA +  V  T A  PVI  T+A     
Sbjct: 1488 PVTPADSPFIPVTTADDPIVPVTPADSPVVPVTPADIPVVPVTPANGPVIHVTSADCPFV 1547

Query: 311  ----TDS--ALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMA 364
                 D   AL   T  +  P S    +  P  + D    +T+   P +        T A
Sbjct: 1548 PVIPADGLVALDSSTDVLVVPVSPTDGVLVPDLADDPVVSVTIADSPVIPV------TPA 1601

Query: 365  QKTIFSTGTPVAAATVAPILATN--TIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATA 422
              T+      +A   V P+ + +   +P     G V+    P    V    P+  S    
Sbjct: 1602 DSTV--VPVTLADGPVVPVTSVDIPVVPVTPANGPVAPV-TPVDDPVVSVNPADGS-VVP 1657

Query: 423  VTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVP 482
            VT+++ PV  V P         + P  PA+ S ++P++    + +PV + T +D+ P +P
Sbjct: 1658 VTSADCPVVPVTP-----ADGLVVPVTPAD-SPIVPVT---PADSPVVLVTSADS-PVIP 1707

Query: 483  VQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPV-SAQAPNSAITAQTGVGVASTVH 541
            V          P+  P+      P+TS+ +     PV SA  P   +T+   + V  T  
Sbjct: 1708 V---------TPADSPV-----VPVTSADTDSPGSPVTSADGPVVPVTSADSLPVPVTPA 1753

Query: 542  LNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQG 601
              P+  +T              AP+S+      P+ TP   P    T       P+    
Sbjct: 1754 DGPVVPVTSADGPV--------APVSSADGPVVPV-TPADSPVVPVTTADDPTVPVTPAD 1804

Query: 602  LQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPA 661
                P+    P   G    V  AD   +   P         +   +V   S +     P 
Sbjct: 1805 SPVVPV----PPANGPIVPVTSADSPFVPVIPADGLVVLDSSTDVLVVPVSPTDGILVPD 1860

Query: 662  QGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNN--------DQPTIAV 713
                P  S+           P ++  V + TP    +  V++ +N        D P I V
Sbjct: 1861 LADDPVVSVTIADSPVIPVTP-ADSPVVLVTPADGPVVPVTSVDNPVVPVTPADNPVIPV 1919

Query: 714  PPTAQQPPPTIPT--MIAAASPPSQPAVALSTIPGAV-PITP---PITTIAAAPPPSVTV 767
             P      P  P    I   +    P V+++     V P+TP   P+  +A+A  P V V
Sbjct: 1920 TPVDDPVVPVTPADDPIVPVTSADSPIVSVTPADSPVFPVTPADSPVIPVASADSPLVPV 1979

Query: 768  GGS---LSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTS 824
              +   +  V+    P I V     P   + P  +     T+  SP + + A++  +P +
Sbjct: 1980 TPADMVVVPVIPADGPVIPVTPAESPAIPVTPTDSPVVPVTSADSPVIPVTADSPFVPVT 2039

Query: 825  DLPPGASP 832
               P  SP
Sbjct: 2040 ---PADSP 2044



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 186/874 (21%), Positives = 299/874 (34%), Gaps = 131/874 (14%)

Query: 37   APSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPV 96
            +P   ++ A S +    SA   +P + V    G    V++ + +              PV
Sbjct: 1703 SPVIPVTPADSPVVPVTSADTDSPGSPVTSADGPVVPVTSADSL--------------PV 1748

Query: 97   VVRPY--PQVQMLSTHHAVA---SATPVAVTAPPAHLTPAVPLSFSEGLMKP------PP 145
             V P   P V + S    VA   SA    V   PA  +P VP++ ++    P      P 
Sbjct: 1749 PVTPADGPVVPVTSADGPVAPVSSADGPVVPVTPAD-SPVVPVTTADDPTVPVTPADSPV 1807

Query: 146  KPTMPSR-PIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHI 204
             P  P+  PI P   +     P +P    V ++SS      +PV+   G       L   
Sbjct: 1808 VPVPPANGPIVPVTSADSPFVPVIPADGLVVLDSST-DVLVVPVSPTDGI------LVPD 1860

Query: 205  MTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPA 264
            +  +  +S+  +++P  P+          A +  V+ +     V+  TS         PA
Sbjct: 1861 LADDPVVSVTIADSPVIPV--------TPADSPVVLVTPADGPVVPVTSVDNPVVPVTPA 1912

Query: 265  VQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQH 324
               +I       P V  + A  P V      T A SP+++ T A +    ++ P  S   
Sbjct: 1913 DNPVIPVTPVDDPVVPVTPADDPIV----PVTSADSPIVSVTPADSPVFPVT-PADSPVI 1967

Query: 325  PPSAAISIQRPAQSRDVTTRITLPSH-PALGTPKQQLHTMAQKTIFSTGTPVAAAT--VA 381
            P ++A S   P    D+     +P+  P +     +   +      S   PV +A   V 
Sbjct: 1968 PVASADSPLVPVTPADMVVVPVIPADGPVIPVTPAESPAIPVTPTDSPVVPVTSADSPVI 2027

Query: 382  PILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHT 441
            P+ A +     T A S      P   +V    P        VT  + PV  V P      
Sbjct: 2028 PVTADSPFVPVTPADSPVIPVTPPDDLVVPVTPIDCP-VVPVTLVDCPVVSVTPAN---- 2082

Query: 442  SPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAA 501
            SP + P  PA+   ++P++    + +PV   T +D+           + +  P+  P+  
Sbjct: 2083 SP-VDPVTPAD-GPVVPVT---PADSPVIPVTPADDLIVPVTPADSLIVSVTPADSPVVP 2137

Query: 502  HTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHI--- 558
               TP  S V ++     SA +P   +T    V V  T    P+  +T   S A  +   
Sbjct: 2138 --VTPADSPVISV----ASADSPVVPVTPADTVVVPVTPADGPVIPVTPAESPAIPVTPA 2191

Query: 559  -QGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQG---------------- 601
               + P   +   + P       I P P  +  +   TP +T G                
Sbjct: 2192 DSPVVPVTPADDPVVPVTPADSPIVPVPPASDPVVPVTPADTPGSPVASADGPVVPVTSA 2251

Query: 602  ---LQPAPMGTQQPQP--------------EGKTSAVVLADGATIVANPISNP-FSAAPA 643
               L P   G     P              +G    V LAD       P  +P F  +PA
Sbjct: 2252 DSPLVPVTPGDSPVVPVTPADSPVFPVTSADGPVFPVTLADDPVFPVTPADDPIFPVSPA 2311

Query: 644  ATTVVQ-THSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMET-- 700
             + VV  T +       P    S  P      P          + +  +T V V + +  
Sbjct: 2312 DSPVVPVTPANIPVVPVPPANGSVVPVTSAGSPFVPIIPADGLVVLDSSTDVLVVLVSPT 2371

Query: 701  -------------VSNQNNDQPTIAVPPTAQQPPPTIPT--MIAAASPPSQPAVALSTIP 745
                         VS   +D P I V PT     P  P    +   +    P V ++   
Sbjct: 2372 DGIPVPDLADDPVVSVTTSDSPVIPVTPTDSPVVPVAPADGPVVPVTSVDSPVVPVTPAD 2431

Query: 746  G-AVPITPPITTIAAAPP---PSVTV---GGSLSSVLGPPVPEIKVKEEVEPMDIMRPVS 798
               +P+TP  + +  A P   P V+V    G +  V    +P I V     P+  + P  
Sbjct: 2432 SPVIPVTPADSLVVPATPADDPVVSVTPADGPVVPVTTADIPVISVTSADSPVVPVTPAD 2491

Query: 799  AVPPLATNTVSPSLALLANNLSMPTSDLPPGASP 832
             +  +   T + S+ + A     P   + P  SP
Sbjct: 2492 GL--VVPVTSADSVVVPATPADCPLVPVDPADSP 2523



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 163/738 (22%), Positives = 252/738 (34%), Gaps = 119/738 (16%)

Query: 112  AVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQ 171
            A+ +  PV    P    +P VP++ ++G +        P  P+ PA    +S+ P     
Sbjct: 360  AIPADGPVVPVTPAD--SPVVPVTPADGPVVSVASADSPFVPVTPADDPIVSVTPADSPV 417

Query: 172  VTVTMESSIPQASAIPVATISGQ------QGHPSNLHHIMTTNVQMSIIRSNAPGPPLHI 225
            V VT   S      IPV T  G+       G P  +  +   +   S + S A GP + +
Sbjct: 418  VPVTSADS----PLIPVTTADGRVVPVTAAGDP--IVPVTPADTPGSPVTS-ADGPVVPV 470

Query: 226  GASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNA----ATAQPAVQHIIHQPIQSRPPVTT 281
             ++ +P             VT+   P + + +A        PA    I        PVTT
Sbjct: 471  TSADIPLVPVTPPDGPVVPVTSADGPVAPVSSADGPVVPVTPADSPFI--------PVTT 522

Query: 282  SN----AIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQ 337
            ++     + PA    +S T A+SP I  T A   DS +  P      P     S   P  
Sbjct: 523  ADDLIVPVTPADSPVLSVTPAESPAIPVTPA---DSPIV-PVTPANGPVVPVTSADSPFV 578

Query: 338  SRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGS 397
                     +P  PA               +    +PV + T+A   A    P+ +    
Sbjct: 579  PVIPADGPVVPVTPA---------DSPVVPVTPADSPVLSVTLADSPAVPVTPADSPVVP 629

Query: 398  VSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLI 457
            V+    P      + V S  S    VT ++ P+  V P +                S  I
Sbjct: 630  VTPADGP-----VVPVASADSPFVPVTPADDPIVSVTPAE----------------SPAI 668

Query: 458  PISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQY 517
            P++    + +PV   T +D RP +PV                A     P+T++   I   
Sbjct: 669  PVT---QADSPVVPVTSAD-RPVIPV--------------TTADGRIVPVTAAGDPI--V 708

Query: 518  PVS-AQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQ--PAPISTQGIQPA 574
            PV+ A  P S +T+  G  V  T   +P   +T        +       AP+S+      
Sbjct: 709  PVTPADTPGSPVTSADGPVVPVTSADSPFVPVTPPDGPVVPVTSADGPVAPVSSADGPVV 768

Query: 575  PIGTPGIQPAPLGTQG--IHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVAN 632
            P+ +     AP+ +    +   TP +T G  PA   T    P      V+ AD   +   
Sbjct: 769  PVTSADGPVAPVSSADGPVVPVTPADTNG--PAVPVTSADSP---FVPVIPADSPVVPVT 823

Query: 633  PISNPF-SAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMA 691
            P  +P     PA ++ V       S ++P     P    +    +TD           + 
Sbjct: 824  PADDPIVPVTPADSSFVPV----ISADSPFVPVIPADGPVVVDSSTDVLVVPVFPVNCIL 879

Query: 692  TPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPT------------MIAAASPPSQPAV 739
             P       V     D P I V P      P  PT             +   +P   PA 
Sbjct: 880  VPAFADETVVPLNPADSPVIPVTPPDDLVVPVTPTDCPVAPVTSADCPVVPVTPADSPAD 939

Query: 740  ALSTIPG-AVPITP---PITTIAAAPPPSVTV---GGSLSSVLGPPVPEIKVKEEVEPMD 792
             ++   G  VP TP   PI  +  A  P V+V    G +  V     P + V    +P+ 
Sbjct: 940  PVTAADGPVVPFTPADDPIVPVTPADSPVVSVTPADGPVVPVASADSPFVPVTPADDPIV 999

Query: 793  IMRPVSAVPPLATNTVSP 810
             + P  +     T   SP
Sbjct: 1000 SVTPAESPAIPVTQADSP 1017



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 159/696 (22%), Positives = 249/696 (35%), Gaps = 105/696 (15%)

Query: 113 VASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQV 172
           V SA    V   PA   P VP++ + G + P      P  P+A A    + + P      
Sbjct: 111 VTSADDPVVPITPAD-NPVVPVTSANGPVIPVTPADSPVFPVASADGPVVPVTPADSPVF 169

Query: 173 TVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPR 232
            VT     P  S +   T +     P      +T     +I  + A GP +H+  ++   
Sbjct: 170 PVT-----PADSPLFPVTPADSPLFP------VTPADSAAIPVTPADGPVVHVTPAN--- 215

Query: 233 GAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVAT 292
           G       + S V TV    S +       PA   I+        PVT +++   + V  
Sbjct: 216 GTVVPVTPADSPVVTVASTDSPV---VPVTPADDPIV--------PVTPADS---SFVPV 261

Query: 293 VSATRAQSPVITTTAAHATDSALS------RPTLSIQHPPSAAISIQRPAQSRDVTTRIT 346
           +SA     PVI        DS+         P   I  P  A  +I        +   +T
Sbjct: 262 ISADSPFVPVIPADGPVVVDSSTDVLVVPVFPVNCILVPAFADETIXXXXXXXSLVVSVT 321

Query: 347 LPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNT--IPSATTAGSVSHTQAP 404
               P +        T A   + S    +A + V P+   ++  +P+    G V      
Sbjct: 322 TADDPIVPV------TPADSPVLS--VTLADSPVVPVTPADSPFVPAIPADGPVVPVTPA 373

Query: 405 TSTIVTMT--------VPSHSSHATAVTTSNIPVAKVVPQQ-----ITHTSPRIQPDYPA 451
            S +V +T        V S  S    VT ++ P+  V P       +T     + P   A
Sbjct: 374 DSPVVPVTPADGPVVSVASADSPFVPVTPADDPIVSVTPADSPVVPVTSADSPLIPVTTA 433

Query: 452 ERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSV 511
           +   ++P++   A+ +P+   T +D  P  PV      P  P ++  +     TP    V
Sbjct: 434 D-GRVVPVT---AAGDPIVPVTPADT-PGSPVT-SADGPVVPVTSADIPLVPVTPPDGPV 487

Query: 512 STIRQYPVSAQAPNSAITAQTGVGVASTVHLNP-MQLMTVDASHARHIQGIQPAPISTQG 570
             +     SA  P + +++  G  V  T   +P + + T D      I  + PA      
Sbjct: 488 VPV----TSADGPVAPVSSADGPVVPVTPADSPFIPVTTADDL----IVPVTPADSPVLS 539

Query: 571 IQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIV 630
           + PA   +P I   P  +  I   TP N     P    T    P      V+ ADG  + 
Sbjct: 540 VTPAE--SPAIPVTPADSP-IVPVTPAN----GPVVPVTSADSP---FVPVIPADGPVVP 589

Query: 631 ANPISNP-FSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVS 689
             P  +P     PA + V+         ++PA   +P  S +      DG         S
Sbjct: 590 VTPADSPVVPVTPADSPVLSV----TLADSPAVPVTPADSPVVPVTPADGPVVPVASADS 645

Query: 690 MATPVTVSME-TVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPG-A 747
              PVT + +  VS    + P I   P  Q   P +P   A      +P + ++T  G  
Sbjct: 646 PFVPVTPADDPIVSVTPAESPAI---PVTQADSPVVPVTSA-----DRPVIPVTTADGRI 697

Query: 748 VPIT---PPITTIAAAPPPSVTVGGSLSSVLGPPVP 780
           VP+T    PI  +     P+ T G  ++S  GP VP
Sbjct: 698 VPVTAAGDPIVPVT----PADTPGSPVTSADGPVVP 729



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 164/712 (23%), Positives = 252/712 (35%), Gaps = 110/712 (15%)

Query: 112  AVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQ 171
            +VASA    V   PA  T  VP++ ++G + P      P+ P+ PA    + + P     
Sbjct: 2147 SVASADSPVVPVTPAD-TVVVPVTPADGPVIPVTPAESPAIPVTPADSPVVPVTPADDPV 2205

Query: 172  VTVTMESS----IPQAS--AIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHI 225
            V VT   S    +P AS   +PV T +   G P                 ++A GP + +
Sbjct: 2206 VPVTPADSPIVPVPPASDPVVPV-TPADTPGSPV----------------ASADGPVVPV 2248

Query: 226  GASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSN-- 283
             ++  P           S V  V    S +    +A   V            PVT ++  
Sbjct: 2249 TSADSP---LVPVTPGDSPVVPVTPADSPVFPVTSADGPVF-----------PVTLADDP 2294

Query: 284  --AIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDV 341
               + PA       + A SPV+  T A+        P + +  PP+    +   +     
Sbjct: 2295 VFPVTPADDPIFPVSPADSPVVPVTPANI-------PVVPV--PPANGSVVPVTSAGSPF 2345

Query: 342  TTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHT 401
               I       L +    L  +   T    G PV      P LA + + S TT+ S    
Sbjct: 2346 VPIIPADGLVVLDSSTDVLVVLVSPT---DGIPV------PDLADDPVVSVTTSDSPVIP 2396

Query: 402  QAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISG 461
              PT + V    P+       VT+ + PV  V P      SP I P  PA+ S ++P + 
Sbjct: 2397 VTPTDSPVVPVAPADGP-VVPVTSVDSPVVPVTPAD----SPVI-PVTPAD-SLVVPAT- 2448

Query: 462  HRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSA-YPLAAHT-----YTPITSSVSTIR 515
               + +PV   T +D  P VPV           SA  P+   T       P+TS+ S + 
Sbjct: 2449 --PADDPVVSVTPADG-PVVPVTTADIPVISVTSADSPVVPVTPADGLVVPVTSADSVVV 2505

Query: 516  QYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPA--PISTQGIQP 573
                 A  P   +       V  T + NP+  +T D S    +     +  P++  G+  
Sbjct: 2506 P-ATPADCPLVPVDPADSPIVLFTPYDNPVVSVTSDDSPVFPVTPADSSVVPVTPAGVPV 2564

Query: 574  APIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANP 633
             P+ TPG  P    T       P+ +      P+ T    P    S    AD   +   P
Sbjct: 2565 VPV-TPGDGPVVPVTPADSLVVPVTSADSPVFPV-TPADSPVFPVSP---ADDLVVPVTP 2619

Query: 634  ISNPF-SAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMAT 692
              +P    +PA + VV           PA G      ++   PA     P +        
Sbjct: 2620 GDSPVVPVSPADSPVVLV--------TPADGP-----VVPVTPANGPVVPVTSADSPFVP 2666

Query: 693  PVTVSMETVSNQNNDQPTIAVPPT-AQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPIT 751
             +      V + + D   + V PT     P      +   +P   P V ++  PG  P+ 
Sbjct: 2667 VIPADGLVVLDSSTDVLVVPVFPTDGILVPDLADDPVVPVTPGDDPVVPVT--PGDDPVI 2724

Query: 752  PPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIM-RPVSAVPP 802
            P +T     P   VT        +GP VP++   + V P  +   PV +V P
Sbjct: 2725 P-VTPADDGPFVPVT------PAVGPVVPDLTADDSVVPDSLTDDPVISVCP 2769



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 173/799 (21%), Positives = 276/799 (34%), Gaps = 168/799 (21%)

Query: 95   PVVVRPYPQVQMLSTHHAVASATP---VAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPS 151
            P  +R +P V   ST   V ++TP   + V   PA     VP++   G + P      P 
Sbjct: 2868 PDPIRAFPVVPKPSTFSPVVTSTPADWIDVIVTPADCAD-VPVNPVNGPVVPDLSGDCPV 2926

Query: 152  RPIAPAPPSTLSLPPKVPGQVTVTMESSIPQAS-------AIPVATISGQQGHP--SNLH 202
             P+ P     +  PP V   V  T  +  P  +        +PV   +G       S   
Sbjct: 2927 VPVPPTDDIVVLNPPDVVFAVVSTPVTDGPVVTDPATDGLMVPVTPANGSVAPVTLSEYP 2986

Query: 203  HIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQ 262
             +  T    +++     GP +       P  +A ++V+S+     ++     +PN   A 
Sbjct: 2987 DVTVTPADGTVVSPTIGGPVV-------PDPSADSSVVSNPTTDGLI-----VPNPLLAG 3034

Query: 263  PAVQHIIHQPIQSRPPVTTSNAIPPAVVAT---VSATRAQSPVIT--TTAAH------AT 311
            P V           P   T   + P ++A    V+ T A  PV+   TT         A 
Sbjct: 3035 PVV-----------PVTPTDGPLAPVILADCPDVTVTPADGPVVCAFTTGGPVFPDPTAE 3083

Query: 312  DSALSRPTLS---IQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTM----- 363
               +S PT+    + +P +  +    PA   DV      P  PA   P   ++ +     
Sbjct: 3084 GLVVSNPTVDDPVVTNPSTKGLVSATPADCADV------PVIPA-DCPDVLVNLVNDSVV 3136

Query: 364  ----AQKTIFSTGTP----------VAAATVAPILATNTIPSATTAG---SVSHTQAPTS 406
                A  T+ S   P               + PI     +P  TT G   SV+   AP  
Sbjct: 3137 PDFTADWTVVSVSPPDDLVAPDPPDEVPVVLVPITDGPVVPDLTTDGLVVSVTPAGAPVV 3196

Query: 407  TI-------VTMT------VPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAER 453
             +       VT+T      VP  SS    V  S +    +VP  +T     + PD PA  
Sbjct: 3197 PVFLTDCPDVTVTPADSPVVPDPSSDGPVVADS-LDDDGLVP--VTPADDSVVPDSPAN- 3252

Query: 454  SSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVST 513
              ++P      +  PVA +   D  P VPV          P+  P  + T          
Sbjct: 3253 GLVVP---DPTTDGPVAPDPSVDG-PVVPVT---------PADAPTVSVTL--------- 3290

Query: 514  IRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQP 573
                   A  P+  +T   G+ V+ +    P+       S    +    PA  S   + P
Sbjct: 3291 -------ADCPDVTVTPPDGLVVSDSKRGGPV---VTGLSTNDPVITATPADFSDVTVTP 3340

Query: 574  APIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLA--DGATIVA 631
            A      + PA      ++  +P+ +       +    P  +     VVL   D   +V 
Sbjct: 3341 ADFEDVPVTPANCPDVPVNPESPVVSDLAVDFLVVPVVPSDD----LVVLEPPDKVPVVP 3396

Query: 632  NPISNPFSAAPAATTVVQTHSQSASTN----APAQGSSPRPSI-----LRKKPATDGAKP 682
            +PISN    +   T        S   +    +PA G     ++     +   PA D    
Sbjct: 3397 DPISNGLVVSDPITNNTAATDPSVDGSVVPVSPADGPVAPVTLADCPDVTITPADDSVVS 3456

Query: 683  KSEIHVSMA-TPVTV-----------SMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAA 730
             S+I       PVT+           S   VS+   D P + +PP         P  + A
Sbjct: 3457 DSKIRAEFEDVPVTIADCPNVPVNPKSGPVVSDLAVDCPVVPIPP---------PDDLVA 3507

Query: 731  ASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEP 790
              PP +  V    I  ++ ++ P+T    A  PS  + G +  V+ P    + V + V  
Sbjct: 3508 PEPPDEVPVVPDPITDSLVVSDPMTDGPVASDPS--IDGIVVPVVSP--SGLLVLDSVAD 3563

Query: 791  MDIMRPVSAVPPLATNTVS 809
            + I+   SA  P+   T++
Sbjct: 3564 VSILPDTSADVPVTPVTLA 3582



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 171/800 (21%), Positives = 274/800 (34%), Gaps = 129/800 (16%)

Query: 100  PYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPP 159
            P P +          S +PV    P    +P VP++ ++G + P    T    P+ P  P
Sbjct: 2375 PVPDLADDPVVSVTTSDSPVIPVTPTD--SPVVPVAPADGPVVP---VTSVDSPVVPVTP 2429

Query: 160  STLSLPPKVPGQVTVTMESSIPQASA-IPVATISGQQGHPSNLHHIMTTNVQ-MSIIRSN 217
            +   + P  P    V     +P   A  PV +++   G    +  + T ++  +S+  ++
Sbjct: 2430 ADSPVIPVTPADSLV-----VPATPADDPVVSVTPADG---PVVPVTTADIPVISVTSAD 2481

Query: 218  APGPPL-HIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATA-QPAVQHIIHQPIQS 275
            +P  P+       +P  +A + V+ ++     L P     +      P    ++      
Sbjct: 2482 SPVVPVTPADGLVVPVTSADSVVVPATPADCPLVPVDPADSPIVLFTPYDNPVVSVTSDD 2541

Query: 276  RP--PVTTSNA----IPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAA 329
             P  PVT +++    + PA V  V  T    PV+  T A     +L  P  S   P    
Sbjct: 2542 SPVFPVTPADSSVVPVTPAGVPVVPVTPGDGPVVPVTPA----DSLVVPVTSADSPVFPV 2597

Query: 330  ISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTI 389
                 P         + +P  P   +P   +       +  T        V P  A   +
Sbjct: 2598 TPADSPVFPVSPADDLVVPVTPG-DSPVVPVSPADSPVVLVTPADGPVVPVTP--ANGPV 2654

Query: 390  PSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDY 449
               T+A S      P   +V +   +         T  I V  +    +   +P   P  
Sbjct: 2655 VPVTSADSPFVPVIPADGLVVLDSSTDVLVVPVFPTDGILVPDLADDPVVPVTPGDDP-- 2712

Query: 450  PAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAH------- 502
                  ++P++      +PV   T +D+ P VPV      P   P    L A        
Sbjct: 2713 ------VVPVT---PGDDPVIPVTPADDGPFVPV-----TPAVGPVVPDLTADDSVVPDS 2758

Query: 503  -TYTPITSSV--------STIRQ--------YPVSAQAPNSAITAQTGVGVAST---VHL 542
             T  P+ S           T+R         YPV+      +      V V  T   V L
Sbjct: 2759 LTDDPVISVCPDDGLVVPDTVRDSDGPEVSVYPVTGPVVTDSAADCPVVSVPLTDGLVVL 2818

Query: 543  NPMQLMTVDASHARHIQG-IQPAPISTQGIQPAP-IGTPGIQPAPLGTQGIHS---ATPI 597
             P     V A H     G + P P+    +   P +  P +  A     G+     A P+
Sbjct: 2819 CPPD--EVPAVHDSVTNGLVVPDPVIDGPVFSNPSVDGPIVPVASADNPGVPDPIRAFPV 2876

Query: 598  NTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPF---SAAPAATTVVQTHSQS 654
              +    +P+ T  P  +     V  AD A +  NP++ P     +       V      
Sbjct: 2877 VPKPSTFSPVVTSTP-ADWIDVIVTPADCADVPVNPVNGPVVPDLSGDCPVVPVPPTDDI 2935

Query: 655  ASTNAP----AQGSSP-RPSILRKKPATDGAK-PKSEIHVSMATPVTVSMETVSNQNNDQ 708
               N P    A  S+P     +   PATDG   P +  + S+A PVT+S         + 
Sbjct: 2936 VVLNPPDVVFAVVSTPVTDGPVVTDPATDGLMVPVTPANGSVA-PVTLS---------EY 2985

Query: 709  PTIAVPP---TAQQPP---PTIPTMIAAASPPSQPAVALSTIPG------AVPITP---P 753
            P + V P   T   P    P +P   A +S  S P      +P        VP+TP   P
Sbjct: 2986 PDVTVTPADGTVVSPTIGGPVVPDPSADSSVVSNPTTDGLIVPNPLLAGPVVPVTPTDGP 3045

Query: 754  ITTIAAAPPPSVTVGGSLSSVL------GPPVPEIKVKEEVEPMDIMRPVSAVPPLATNT 807
            +  +  A  P VTV  +   V+      GP  P+       E + +  P +   P+ TN 
Sbjct: 3046 LAPVILADCPDVTVTPADGPVVCAFTTGGPVFPD----PTAEGLVVSNP-TVDDPVVTN- 3099

Query: 808  VSPSLALLANNLSMPTSDLP 827
              PS   L +      +D+P
Sbjct: 3100 --PSTKGLVSATPADCADVP 3117


>gi|239752529 PREDICTED: similar to mucin [Homo sapiens]
          Length = 594

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 111/489 (22%), Positives = 172/489 (35%), Gaps = 77/489 (15%)

Query: 71  DSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTP 130
           DS   +   ++S+ +         P+       ++  +T H+  S T +  T     L+P
Sbjct: 28  DSTSHSNPSLTSAITTTETRSHSPPIFTSSITTIE--TTSHSTPSFTSLMTTTETTSLSP 85

Query: 131 -AVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVA 189
            A   S S         P+  S       PS    PP     +T T  +S    S   V 
Sbjct: 86  PAFTFSISTTETNSHSPPSFTSSIATTETPS--HSPPSFTSLITTTESTSHSPLSFTSVI 143

Query: 190 TISGQQGH--PSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTT 247
           T +    H  PS    I TT                    SH P          +S +TT
Sbjct: 144 TTTESTSHSTPSFTSSIATTET-----------------TSHTPPSF-------TSLITT 179

Query: 248 VLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTT------SNAIPPAVVATVSATRAQSP 301
              P+   P+  +   A +   H P      + T      S  I  +++AT  +T   +P
Sbjct: 180 TETPSHSNPSFTSLITATESTSHSPPSFTSAIATTGITSHSTPIFTSLIATTDSTSHSTP 239

Query: 302 VITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLH 361
             T++       + S P+ S     +   S   P+ +  +TT  T  S P+L +      
Sbjct: 240 SFTSSITSTETISHSTPSFSSLITATKTTSHSTPSLTSLITTTNTSHSTPSLTSLVTSTE 299

Query: 362 TMAQKTIFSTGTPVAAATVAPILAT-----NTIPSATTAGSVSHTQAPTSTIVTMTVPSH 416
           T       S  TP   + +  I AT     +   S TT G+ SH+  P+ T +T T+   
Sbjct: 300 TA------SHSTPSFTSLITTIEATSHSTPSLTSSITTTGTTSHS-TPSFTYLT-TITES 351

Query: 417 SSHATAVTTSNIPVAKVVPQQITHTSPR-IQPDYPAERSSLIPISGHRASPNPVAMETRS 475
           +SH+T   TS I   + +   I   +P  I P  P+  S +               ET S
Sbjct: 352 TSHSTPSLTSAITTTETMSHSILGFTPSIISPSTPSYISLI------------ATTETPS 399

Query: 476 DNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVG 535
            + PS P            +    A+H+   +TS++ST      S     S IT      
Sbjct: 400 HSTPSFPSSI---------TTTQSASHSTPSLTSAISTTEAMSHSIPVFTSLITT----- 445

Query: 536 VASTVHLNP 544
             +T HL P
Sbjct: 446 TETTSHLPP 454



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 76/328 (23%), Positives = 120/328 (36%), Gaps = 39/328 (11%)

Query: 108 STHHAVASATPVAVTAPPAHLTPAVP--LSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLP 165
           +T H+  S T +  T   +H TP++   ++ +E      P  T     I     ST SL 
Sbjct: 267 TTSHSTPSLTSLITTTNTSHSTPSLTSLVTSTETASHSTPSFTSLITTIEATSHSTPSLT 326

Query: 166 PKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQM--------SIIRSN 217
             +    T T   S P  + +   T S     PS    I TT            SII  +
Sbjct: 327 SSIT--TTGTTSHSTPSFTYLTTITESTSHSTPSLTSAITTTETMSHSILGFTPSIISPS 384

Query: 218 APGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRP 277
            P     I  +  P  +  +   S +   +    T  L +A +   A+ H I        
Sbjct: 385 TPSYISLIATTETPSHSTPSFPSSITTTQSASHSTPSLTSAISTTEAMSHSIPVFTSLIT 444

Query: 278 PVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHP-PSAAISIQRPA 336
              T++ +PP   + ++ T+      TT+ +  + +AL   T +  H  PS   SI    
Sbjct: 445 TTETTSHLPPRFTSLITTTK------TTSHSPPSFTALITSTKTTSHSTPSFTSSI---- 494

Query: 337 QSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPS----- 391
                TT  T  S P+  +      T       S  TP  ++++A    T+T P      
Sbjct: 495 ----ATTETTSHSPPSFTSSSTTTET------HSHSTPGFSSSIATSKTTSTSPPRFTFA 544

Query: 392 -ATTAGSVSHTQAPTSTIVTMTVPSHSS 418
            ATT  ++  T   T  I +    SHS+
Sbjct: 545 IATTKTTLHSTPRFTLAIASTKTTSHST 572



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 30/136 (22%), Positives = 52/136 (38%), Gaps = 3/136 (2%)

Query: 628 TIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIH 687
           T     +S P      +TT   +HS  + T++ A   +P  S           +  S   
Sbjct: 77  TTETTSLSPPAFTFSISTTETNSHSPPSFTSSIATTETPSHSPPSFTSLITTTESTSHSP 136

Query: 688 VSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGA 747
           +S  + +T +  T  +  +   +IA   T    PP+  ++I     PS    + +++  A
Sbjct: 137 LSFTSVITTTESTSHSTPSFTSSIATTETTSHTPPSFTSLITTTETPSHSNPSFTSLITA 196

Query: 748 VPIT---PPITTIAAA 760
              T   PP  T A A
Sbjct: 197 TESTSHSPPSFTSAIA 212


>gi|56549668 AT rich interactive domain 2 (ARID, RFX-like) [Homo
            sapiens]
          Length = 1835

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 137/633 (21%), Positives = 216/633 (34%), Gaps = 107/633 (16%)

Query: 272  PIQ---SRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSA 328
            PIQ    + PV+TS      V +    + A SP      +    +   R  ++ Q     
Sbjct: 607  PIQMYYQQQPVSTSVV---RVDSVPDVSPAPSPAGIPHGSQTIGNHFQRTPVANQSSNLT 663

Query: 329  AISIQRPAQSRDVTTRIT--LPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILAT 386
            A  +  P Q      +    +P +P+  T +QQ    A  T+  +  P+    V   +  
Sbjct: 664  ATQMSFPVQGVHTVAQTVSRIPQNPSPHTHQQQ---NAPVTVIQSKAPIPCEVVKATVIQ 720

Query: 387  NTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQ 446
            N+IP      S++    P  + V   V +HS+    VT  N       P  I   SP + 
Sbjct: 721  NSIPQTGVPVSIAVGGGPPQSSV---VQNHSTGPQPVTVVNSQTLLHHPSVIPQQSP-LH 776

Query: 447  PDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTP 506
               P +  S  P++  + +     M  R  N P+                          
Sbjct: 777  TVVPGQIPSGTPVTVIQQAVPQSHMFGRVQNIPAC------------------------- 811

Query: 507  ITSSVSTIRQYPVSAQAPNSAITAQTGVGVAS--TVHLNPMQLMTVDASHARHIQGIQPA 564
             TS+VS  +Q   ++  P    + QT  G  S  TV + P Q +T  AS+      +Q  
Sbjct: 812  -TSTVSQGQQLITTSPQPVQTSSQQTSAGSQSQDTVIIAPPQYVTTSASNIVSATSVQNF 870

Query: 565  PISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLA 624
             ++T G      G P  Q + +G Q I            P P+ +QQ             
Sbjct: 871  QVAT-GQMVTIAGVPSPQASRVGFQNI-----------APKPLPSQQVS----------- 907

Query: 625  DGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKS 684
              +T+V  PI  P      +  +V   +Q   T APA        I+   PA   A    
Sbjct: 908  --STVVQQPIQQPQQPTQQSVVIVSQPAQQGQTYAPA-----IHQIVLANPAALPAGQTV 960

Query: 685  EIHVSMATPVTVSMETVSNQNNDQPTI---AVPPTAQQPPPTIPTMIAAASPPSQPAVAL 741
            ++        + S   V   NN  PT    +  P +Q PPPT+  M++      Q     
Sbjct: 961  QLTGQPNITPSSSPSPVPATNNQVPTAMSSSSTPQSQGPPPTVSQMLSVKRQQQQ----- 1015

Query: 742  STIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVP 801
                             A PP  V V      V  P   +++V+ +     + +P S   
Sbjct: 1016 -------------QHSPAPPPQQVQV-----QVQQPQQVQMQVQPQQSNAGVGQPASGES 1057

Query: 802  PLATNTVSPSL--ALLANNLSMPTSDLPPGASPR-KKPRKQQHVISTEEGDMMETNSTDD 858
             L    + P    +     L +P   +PP  + R   P+    V S +         T  
Sbjct: 1058 SLIKQLLLPKRGPSTPGGKLILPAPQIPPPNNARAPSPQVVYQVASNQAAGFGVQGQT-- 1115

Query: 859  EKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPV 891
                A+ LLV  +  +  P       GV+ VP+
Sbjct: 1116 ---PAQQLLVGQQNVQLVPSAMPPSGGVQTVPI 1145



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 120/588 (20%), Positives = 207/588 (35%), Gaps = 101/588 (17%)

Query: 144  PPKPTMPSRPIAPAPPSTLSLPPKVPGQVT--VTMESSIPQASAIPVATISGQ------- 194
            P  P+  +     AP + +     +P +V     +++SIPQ + +PV+   G        
Sbjct: 685  PQNPSPHTHQQQNAPVTVIQSKAPIPCEVVKATVIQNSIPQ-TGVPVSIAVGGGPPQSSV 743

Query: 195  -QGHPSNLHHIMTTNVQMSIIRSNA--PGPPLH-IGASHLPRGAAAAAVMSSSKVTTVLR 250
             Q H +    +   N Q  +   +      PLH +    +P G     +  +   + +  
Sbjct: 744  VQNHSTGPQPVTVVNSQTLLHHPSVIPQQSPLHTVVPGQIPSGTPVTVIQQAVPQSHMFG 803

Query: 251  PTSQLPNAATAQPAVQHIIH---QPIQSRPPVTTSNA--------IPPAVVAT-----VS 294
                +P   +     Q +I    QP+Q+    T++ +         PP  V T     VS
Sbjct: 804  RVQNIPACTSTVSQGQQLITTSPQPVQTSSQQTSAGSQSQDTVIIAPPQYVTTSASNIVS 863

Query: 295  ATRAQSPVITT----TAAHATDSALSRPTLSIQHP---PSAAIS---IQRPAQSRDVTTR 344
            AT  Q+  + T    T A       SR       P   PS  +S   +Q+P Q     T+
Sbjct: 864  ATSVQNFQVATGQMVTIAGVPSPQASRVGFQNIAPKPLPSQQVSSTVVQQPIQQPQQPTQ 923

Query: 345  --ITLPSHPALG--TPKQQLHTM---------AQKTIFSTGTP--VAAATVAPILATNT- 388
              + + S PA    T    +H +         A +T+  TG P    +++ +P+ ATN  
Sbjct: 924  QSVVIVSQPAQQGQTYAPAIHQIVLANPAALPAGQTVQLTGQPNITPSSSPSPVPATNNQ 983

Query: 389  IPSATTAGSVSHTQAPTSTIVTMTV---PSHSSHATAVTTSNIPVAKVVPQQITHTSPRI 445
            +P+A ++ S   +Q P  T+  M          H+ A     + V    PQQ+     ++
Sbjct: 984  VPTAMSSSSTPQSQGPPPTVSQMLSVKRQQQQQHSPAPPPQQVQVQVQQPQQV---QMQV 1040

Query: 446  QPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYT 505
            QP   +      P SG  +    + +  R  + P   +      P  PP           
Sbjct: 1041 QPQQ-SNAGVGQPASGESSLIKQLLLPKRGPSTPGGKLILP--APQIPP----------- 1086

Query: 506  PITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLN---PMQLMTVDASHARHIQGIQ 562
                        P +A+AP+  +  Q     A+   +    P Q + V   + + +    
Sbjct: 1087 ------------PNNARAPSPQVVYQVASNQAAGFGVQGQTPAQQLLVGQQNVQLVPSAM 1134

Query: 563  PAPISTQGIQPAPIGTPGIQPAPLGTQG---IHSATPINTQGLQPAPMGTQQPQ--PEGK 617
            P    + G+Q  PI    I P PL +     I   T  N   +   P  +  P    +G 
Sbjct: 1135 PP---SGGVQTVPISNLQILPGPLISNSPATIFQGTSGNQVTITVVPNTSFAPATVSQGN 1191

Query: 618  TSAVVLADGATI--VANPISNPFSAAPAATTVVQTHSQSASTNAPAQG 663
             + ++   G T+      +  P    PA        S   +   P +G
Sbjct: 1192 ATQLIAPAGITMSGTQTGVGLPVQTLPATQASPAGQSSCTTATPPFKG 1239


>gi|239743291 PREDICTED: mucin 3A, intestinal [Homo sapiens]
          Length = 1486

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 167/800 (20%), Positives = 279/800 (34%), Gaps = 107/800 (13%)

Query: 59   NPAATVNDESGRDS-EVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASAT 117
            +P +TV D + + +   S    +S+ +SL               P   +++T   ++S  
Sbjct: 339  SPTSTVTDSTTKIAYSTSMTGTLSTETSLPPTSSSLPTTETATTPMTNLVTTTTEISS-- 396

Query: 118  PVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTME 177
                     H TP+   S     +     P   S       PS  +  P+     T T  
Sbjct: 397  ---------HSTPSFSSSTIYSTVTSHSTPRFTSSITTTETPSHST--PRFTSSFTNTKT 445

Query: 178  SSIPQASAIPVATISGQQGH--PSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAA 235
            +S    S   + T +    H  PS    I TT       RS           SH  R   
Sbjct: 446  TSHRSPSFTSLITTTETTSHSTPSFTSSITTTETTSHSARSFTSSITTTETTSHNTRSFT 505

Query: 236  AAAVMSSSKVTTVLRPTSQLPNAATAQ---PAVQHII---HQPIQSRPPVT-------TS 282
            ++   + +   +    TS +    T     P+    I     P+ S P +T       T+
Sbjct: 506  SSITTTETNSHSTTSFTSSITTTETTSHSTPSFSSSITTTETPLHSTPGLTSWVTTTKTT 565

Query: 283  NAIPPAVVATVSATRAQSP---------VITTTAAHATDSALSRPTLSIQHPPSAAISIQ 333
            + I P + ++++ T   S            T T + +T S  S    S     + AI+  
Sbjct: 566  SHITPGLTSSITTTETTSHSTPGFTSSITTTETTSESTPSLSSSTIYSTVSTSTTAITSH 625

Query: 334  RPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATN--TIPS 391
                   VT     PS  +   P   L T+   ++  T T +   T  P + T+  T+P+
Sbjct: 626  FTTSETAVTPTPVTPSSLSTDIPTTSLRTLTPSSV-GTSTSLTTTTDFPSIPTDISTLPT 684

Query: 392  AT--TAGSVSHTQAPTSTIVTMTVPSHSS-HATAVTTSNIPVAK------VVPQQITHTS 442
             T   + S S     TS++V  T P+ S+   T   T N P++       V+P+  T T 
Sbjct: 685  RTHIISSSPSIQSTETSSLVGTTSPTMSTVRMTLRITENTPISSFSTSIVVIPETPTQTP 744

Query: 443  PRIQPDYPAERS---SLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAY-- 497
            P +      + S   + +      +S + +   T S    ++    Q  +P+   S    
Sbjct: 745  PVLTSATGTQTSPAPTTVTFGSTDSSTSTLHTLTPSTALSTIVSTSQVPIPSTHSSTLQT 804

Query: 498  -PLAAHTYTPITS-SVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHA 555
             P      T +TS S  T   +   + + N+ +T+ + +  +ST    P  +M+   S A
Sbjct: 805  TPSTPSLQTSLTSTSEFTTESFTRGSTSTNAILTSFSTIIWSST----PTIIMSSSPSSA 860

Query: 556  R---------HIQGIQPAPISTQGIQPAPI-GTPGIQPAPLG---------TQGIHSATP 596
                      H     P   ST+ +  A I G P +  +            T  +   TP
Sbjct: 861  SITPVFSTTIHSVPSSPYIFSTENVGSASITGFPSLSSSATTSTSSTSSSLTTALTEITP 920

Query: 597  ---INTQGLQPAPMG-TQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQ--- 649
               I+     P P   T    P   T   V  D +T   +P + P +  P  T +V    
Sbjct: 921  FSYISLPSTTPCPGTITITIVPASPTDPCVEMDPSTEATSPPTTPLTVFPFTTEMVTCPT 980

Query: 650  --------THSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETV 701
                    T     S+  P   SS  P+         G  P + +  S   P + +   +
Sbjct: 981  SISIQTTLTTYMDTSSMMPESESSISPNA--SSSTGTGTVPTNTVFTSTRLPTSETW--L 1036

Query: 702  SNQNN---DQPTIAVPPTAQQPPPTIPTMIAAASP---PSQPAVALSTIPGAVPITPPIT 755
            SN +      P ++  P   +P  ++PT++  +S    PS P    S  P A   TP  T
Sbjct: 1037 SNSSVIPLPLPGVSTIPLTMKPSSSLPTILRTSSKSTHPSPPTTRTSETPVATTQTP--T 1094

Query: 756  TIAAAPPPSVTVGGSLSSVL 775
            T+ +     +T   +  S L
Sbjct: 1095 TLTSRRTTRITSQMTTQSTL 1114



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 169/836 (20%), Positives = 301/836 (36%), Gaps = 126/836 (15%)

Query: 74   VSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVT----------A 123
            V++   ++SS +  +          +P     + S    + S+TPV  T           
Sbjct: 253  VTSTSPITSSITSTNTVTSMTTTASQPTATNTLSSPTRTILSSTPVLSTETITSGITNTT 312

Query: 124  PPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQA 183
            P + L   +P + S     P  + T P+ P +    ST  +        T++ E+S+P  
Sbjct: 313  PLSTLVTTLPTTISRST--PTSETTYPTSPTSTVTDSTTKIAYSTSMTGTLSTETSLPPT 370

Query: 184  SAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSS 243
            S    +++   +   + + +++TT  ++S     +   P    ++      + +    +S
Sbjct: 371  S----SSLPTTETATTPMTNLVTTTTEIS-----SHSTPSFSSSTIYSTVTSHSTPRFTS 421

Query: 244  KVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAI---PPAVVATVSATR--- 297
             +TT   P+   P   ++    +   H+       +TT+       P+  ++++ T    
Sbjct: 422  SITTTETPSHSTPRFTSSFTNTKTTSHRSPSFTSLITTTETTSHSTPSFTSSITTTETTS 481

Query: 298  ------AQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHP 351
                    S   T T +H T S  S  T +  +  S   S      + + T+  T     
Sbjct: 482  HSARSFTSSITTTETTSHNTRSFTSSITTTETNSHSTT-SFTSSITTTETTSHSTPSFSS 540

Query: 352  ALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTM 411
            ++ T +  LH+    T + T T   +     + ++ T    T+  +   T + T+T  T 
Sbjct: 541  SITTTETPLHSTPGLTSWVTTTKTTSHITPGLTSSITTTETTSHSTPGFTSSITTTETTS 600

Query: 412  -TVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRA-SPNPV 469
             + PS SS     T S    A       + T+    P  P+  S+ IP +  R  +P+ V
Sbjct: 601  ESTPSLSSSTIYSTVSTSTTAITSHFTTSETAVTPTPVTPSSLSTDIPTTSLRTLTPSSV 660

Query: 470  AME---TRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNS 526
                  T + + PS+P      + T P         T T I SS  +I+    S+    +
Sbjct: 661  GTSTSLTTTTDFPSIPTD----ISTLP---------TRTHIISSSPSIQSTETSSLVGTT 707

Query: 527  AITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPL 586
            + T  T   V  T+ +      T  +S +  I  I   P  T  +  +  GT    PAP 
Sbjct: 708  SPTMST---VRMTLRITE---NTPISSFSTSIVVIPETPTQTPPVLTSATGTQ-TSPAPT 760

Query: 587  ---------GTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNP 637
                      T  +H+ TP  +  L      +Q P P   +S        T+   P +  
Sbjct: 761  TVTFGSTDSSTSTLHTLTP--STALSTIVSTSQVPIPSTHSS--------TLQTTPSTPS 810

Query: 638  FSAAPAATTVVQTHS---QSASTNAPAQG------SSPRPSILRKKPATDGAKP--KSEI 686
               +  +T+   T S    S STNA          SS    I+   P++    P   + I
Sbjct: 811  LQTSLTSTSEFTTESFTRGSTSTNAILTSFSTIIWSSTPTIIMSSSPSSASITPVFSTTI 870

Query: 687  HVSMATPVTVSMETV------------------SNQNNDQPTIAVP----------PTAQ 718
            H   ++P   S E V                  ++  +   T A+           P+  
Sbjct: 871  HSVPSSPYIFSTENVGSASITGFPSLSSSATTSTSSTSSSLTTALTEITPFSYISLPSTT 930

Query: 719  QPPPTIPTMIAAASPPSQPAVAL-----STIPGAVPITP-PITTIAAAPPPSVTVGGSLS 772
              P TI   I  AS P+ P V +     +T P   P+T  P TT     P S+++  +L+
Sbjct: 931  PCPGTITITIVPAS-PTDPCVEMDPSTEATSPPTTPLTVFPFTTEMVTCPTSISIQTTLT 989

Query: 773  SVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPP 828
            + +       + +  + P       +   P  TNTV  S  L  +   +  S + P
Sbjct: 990  TYMDTSSMMPESESSISPNASSSTGTGTVP--TNTVFTSTRLPTSETWLSNSSVIP 1043



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 148/741 (19%), Positives = 254/741 (34%), Gaps = 102/741 (13%)

Query: 196 GHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRG-----------------AAAAA 238
           GH  N    +TT+   ++I       P+    S  P                   A    
Sbjct: 69  GHRENAPMTLTTSPHDTLISETLLNSPVSSNTSTTPTSKFAFKVETTPPTVLVYSATTEC 128

Query: 239 VMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRA 298
           V  +S + T+  PTS      T Q A          ++ PVTT       V +T S T  
Sbjct: 129 VYPTSFIITISHPTSIC--VTTTQVAFTSSYTSTPVTQKPVTT-------VTSTYSMTTT 179

Query: 299 QSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQ 358
           +      T++ +T +A   P +++   PS+  +      +   +T  T    P    P  
Sbjct: 180 EKGTSAMTSSPSTTTARETPIVTVT--PSSVSATDTTFHTTISSTTRTTERTPL---PTG 234

Query: 359 QLHTMAQKTIFSTGTPVAAATVAPILA----TNTIPSATTAGS----VSHTQAPTSTIVT 410
            +HT    T   T    A  + +PI +    TNT+ S TT  S     +   +PT TI++
Sbjct: 235 SIHTTTSPTPVFTTLKTAVTSTSPITSSITSTNTVTSMTTTASQPTATNTLSSPTRTILS 294

Query: 411 MTVPSHSSHATAVTTSNIPVAKVV---PQQITHTSPRIQPDYPAERSSLIPISGHRASPN 467
            T    +   T+  T+  P++ +V   P  I+ ++P  +  YP   +S +  S  + + +
Sbjct: 295 STPVLSTETITSGITNTTPLSTLVTTLPTTISRSTPTSETTYPTSPTSTVTDSTTKIAYS 354

Query: 468 PVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSA 527
             +M        S+P       PT   S+ P      TP+T+ V+T  +    +    S+
Sbjct: 355 -TSMTGTLSTETSLP-------PT--SSSLPTTETATTPMTNLVTTTTEISSHSTPSFSS 404

Query: 528 ITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLG 587
            T  + V   ST         T   SH+           S    +     +P        
Sbjct: 405 STIYSTVTSHSTPRFTSSITTTETPSHS-----TPRFTSSFTNTKTTSHRSPSFTSLITT 459

Query: 588 TQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADG--------ATIVANPISNPFS 639
           T+    +TP  T  +      T        TS++   +          + +    +N  S
Sbjct: 460 TETTSHSTPSFTSSITTTE--TTSHSARSFTSSITTTETTSHNTRSFTSSITTTETNSHS 517

Query: 640 AAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDG----AKPKSEIHVSMATPVT 695
                +++  T + S ST + +   +   + L   P         K  S I   + + +T
Sbjct: 518 TTSFTSSITTTETTSHSTPSFSSSITTTETPLHSTPGLTSWVTTTKTTSHITPGLTSSIT 577

Query: 696 VSMETVSNQNNDQPTIAVPPTAQQPPP------------TIPTMIAAASPPSQPAVALST 743
            +  T  +      +I    T  +  P            T  T I +    S+ AV  + 
Sbjct: 578 TTETTSHSTPGFTSSITTTETTSESTPSLSSSTIYSTVSTSTTAITSHFTTSETAVTPTP 637

Query: 744 I-PGAVPITPPITTIAAAPPPSVTVGGSLSSVLG-PPVPE-----------IKVKEEVEP 790
           + P ++    P T++    P SV    SL++    P +P            I     ++ 
Sbjct: 638 VTPSSLSTDIPTTSLRTLTPSSVGTSTSLTTTTDFPSIPTDISTLPTRTHIISSSPSIQS 697

Query: 791 MDIMRPVSAVPPLATNTVSPSLALLANN--LSMPTSDLPPGASPRKKPRKQQHVISTEEG 848
            +    V    P   +TV  +L +  N    S  TS +    +P + P        T+  
Sbjct: 698 TETSSLVGTTSP-TMSTVRMTLRITENTPISSFSTSIVVIPETPTQTPPVLTSATGTQTS 756

Query: 849 DMMET---NSTDDEKSTAKSL 866
               T    STD   ST  +L
Sbjct: 757 PAPTTVTFGSTDSSTSTLHTL 777


>gi|222352122 hypothetical protein LOC284297 [Homo sapiens]
          Length = 1573

 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 132/599 (22%), Positives = 198/599 (33%), Gaps = 97/599 (16%)

Query: 220  GPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPV 279
            GP L  G +  P       V   +       P  + P  A  + A       P  S  P 
Sbjct: 959  GPTLGAGTTRSPGSPPTLRVHGDTGSPRKPWPERRPPRPAATRTA------PPTPSPGPS 1012

Query: 280  TTSNAIPPAVVATVSATRAQSPVITTTAAHATDSA-LSRPTLSIQHPPSAAISIQRPAQS 338
             +    PP    T  ++R  +P    T+   +D+   S PT       +  + +  P  +
Sbjct: 1013 ASPG--PPGPALTSDSSRELTPHSALTSEATSDAPDTSPPTPDPASRTNPDLILTSPDFA 1070

Query: 339  RDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSV 398
                    +P+     +P   L T+ ++      TP    +++P   +  +P + T   +
Sbjct: 1071 LSTPDSSVVPALTPEPSPTP-LPTLPKELTSDPSTPSEVTSLSP--TSEQVPESDTTPDL 1127

Query: 399  SHTQAPTSTIVT----MTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAE-- 452
              T  P S+ V+       PS S H T       P   + P  IT  +P + P +P    
Sbjct: 1128 DTT--PYSSTVSEYSRSPDPSPSPHPTTT-----PDPTMAPDPITTLNPTVTPHFPTTPH 1180

Query: 453  -----------RSSLIPISGHRASPNPVAMETRSDNRP---SVPVQFQYFLPTYPP-SAY 497
                        S++IP      +P P    T S   P   + P  F    PT  P S  
Sbjct: 1181 PTTTPHPTTITHSTMIP--DPTTTPQPFTTITHSTMIPDPTTTPQPFTTMQPTTTPHSTT 1238

Query: 498  PLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVH--LNPMQLMTVDASHA 555
            P    T  P T + ST+   P +   P + +   T     +T H    P    T   +  
Sbjct: 1239 PHPTTTPHPTTITHSTMIPDPTTTPQPFTTMQPTTMPHPTTTPHPTTTPHPTTTPHPTTT 1298

Query: 556  RHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPE 615
             H   + P P +T    P P  TP     P  T    S+TP+ T    P  +GT+   P 
Sbjct: 1299 PH-PTMTPDPTTT----PYPTTTPDPTTTPHPTTPDPSSTPVITTVSLPTSLGTELSSP- 1352

Query: 616  GKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKP 675
                                       A T     H Q   T      S+ +   L   P
Sbjct: 1353 -------------------------TLAPTVKPSLHPQLTFTAPAPHTSTSQIPTLEPSP 1387

Query: 676  ATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPT---------AQQPPPTI-P 725
            A + +  +S    SM     +S E      +  P +  PPT            P P + P
Sbjct: 1388 ALESSPSRSSTATSMDP---LSTEDFKPPRSQSPNLTPPPTHTPHSASDLTVSPDPLLSP 1444

Query: 726  TMIAAASPPSQPAVALSTIPGAVP--------ITPPITTIAAAPPPSVTVGGSLSSVLG 776
            T      PP  P + L   PG  P         TPP+  +A  PP  V +  ++  V G
Sbjct: 1445 TAHPLDHPPLDP-LTLGPTPGQSPGPHGPCVAPTPPVRVMACEPPALVELVAAVRDVGG 1502



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 133/565 (23%), Positives = 194/565 (34%), Gaps = 95/565 (16%)

Query: 144  PPKPTMPSRPIAPAPPSTLSLPPKV-PGQVTVTMESSIPQASAIPVA-TISGQQGHPSNL 201
            P KP    RP  P P +T + PP   PG          P AS  P    ++         
Sbjct: 985  PRKPWPERRP--PRPAATRTAPPTPSPG----------PSASPGPPGPALTSDSSRELTP 1032

Query: 202  HHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATA 261
            H  +T+        ++ P P         P       ++ +S    +  P S +  A T 
Sbjct: 1033 HSALTSEATSDAPDTSPPTPD--------PASRTNPDLILTSPDFALSTPDSSVVPALTP 1084

Query: 262  QPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHAT---DSALSRP 318
            +P+       P+ + P   TS+   P+ V ++S T  Q P   TT    T    S +S  
Sbjct: 1085 EPSPT-----PLPTLPKELTSDPSTPSEVTSLSPTSEQVPESDTTPDLDTTPYSSTVSEY 1139

Query: 319  TLSIQHPPSA-AISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTI-FSTGTPVA 376
            + S    PS    +   P  + D  T +     P   T      T    TI  ST  P  
Sbjct: 1140 SRSPDPSPSPHPTTTPDPTMAPDPITTLNPTVTPHFPTTPHPTTTPHPTTITHSTMIPDP 1199

Query: 377  AATVAP---ILATNTIPSATTAGSVSHTQAPTSTIVTMTV-PSHSSHATAVTTSN-IPVA 431
              T  P   I  +  IP  TT      T  PT+T  + T  P+ + H T +T S  IP  
Sbjct: 1200 TTTPQPFTTITHSTMIPDPTTTPQPFTTMQPTTTPHSTTPHPTTTPHPTTITHSTMIPDP 1259

Query: 432  KVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPT 491
               PQ  T   P   P +P              +P+P    T        P    Y   T
Sbjct: 1260 TTTPQPFTTMQPTTMP-HPTTTPHPTTTPHPTTTPHPTT--TPHPTMTPDPTTTPYPTTT 1316

Query: 492  YPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVH--LNPMQLMT 549
              P+  P   H  TP  SS   I     +   P S  T  +   +A TV   L+P    T
Sbjct: 1317 PDPTTTP---HPTTPDPSSTPVI----TTVSLPTSLGTELSSPTLAPTVKPSLHPQLTFT 1369

Query: 550  VDASHAR--HIQGIQPAP-----------------ISTQGIQPAPIGTPGIQPAPLGTQG 590
              A H     I  ++P+P                 +ST+  +P    +P + P P  T  
Sbjct: 1370 APAPHTSTSQIPTLEPSPALESSPSRSSTATSMDPLSTEDFKPPRSQSPNLTPPPTHTP- 1428

Query: 591  IHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQT 650
             HSA+ +           T  P P       +L+  A  + +P  +P +  P       T
Sbjct: 1429 -HSASDL-----------TVSPDP-------LLSPTAHPLDHPPLDPLTLGP-------T 1462

Query: 651  HSQSASTNAPAQGSSPRPSILRKKP 675
              QS   + P    +P   ++  +P
Sbjct: 1463 PGQSPGPHGPCVAPTPPVRVMACEP 1487



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 111/484 (22%), Positives = 162/484 (33%), Gaps = 95/484 (19%)

Query: 385  ATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHA--TAVTTSNIP-VAKVVPQQITHT 441
            AT T P   + G  +    P   + + +    + H+  T+  TS+ P  +   P   + T
Sbjct: 999  ATRTAPPTPSPGPSASPGPPGPALTSDSSRELTPHSALTSEATSDAPDTSPPTPDPASRT 1058

Query: 442  SPRI---QPDYPAER--SSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSA 496
            +P +    PD+      SS++P      SP P+         P++P +      T  PS 
Sbjct: 1059 NPDLILTSPDFALSTPDSSVVPALTPEPSPTPL---------PTLPKEL-----TSDPS- 1103

Query: 497  YPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHAR 556
                  T + +TS   T  Q P S   P+   T  +     STV              + 
Sbjct: 1104 ------TPSEVTSLSPTSEQVPESDTTPDLDTTPYS-----STV--------------SE 1138

Query: 557  HIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEG 616
            + +   P+P       P P  TP    AP     I +  P  T      P  T  P P  
Sbjct: 1139 YSRSPDPSP------SPHPTTTPDPTMAP---DPITTLNPTVTPHFPTTPHPTTTPHPTT 1189

Query: 617  KTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPA 676
             T + ++ D  T        PF      TT+  THS    T  P   ++P+P    +   
Sbjct: 1190 ITHSTMIPDPTTT-----PQPF------TTI--THS----TMIPDPTTTPQPFTTMQPTT 1232

Query: 677  TDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQ 736
            T  +           T +T S          QP   + PT    P T P       P + 
Sbjct: 1233 TPHSTTPHPTTTPHPTTITHSTMIPDPTTTPQPFTTMQPTTMPHPTTTPHPTTTPHPTTT 1292

Query: 737  PAVALSTIPGAVP---------ITPPITTI--AAAPPPS-------VTVGGSLSSVLGPP 778
            P    +  P   P          TP  TT      P PS       V++  SL + L  P
Sbjct: 1293 PHPTTTPHPTMTPDPTTTPYPTTTPDPTTTPHPTTPDPSSTPVITTVSLPTSLGTELSSP 1352

Query: 779  VPEIKVKEEVEP---MDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKK 835
                 VK  + P        P ++   + T   SP+L    +  S  TS  P      K 
Sbjct: 1353 TLAPTVKPSLHPQLTFTAPAPHTSTSQIPTLEPSPALESSPSRSSTATSMDPLSTEDFKP 1412

Query: 836  PRKQ 839
            PR Q
Sbjct: 1413 PRSQ 1416



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 110/497 (22%), Positives = 160/497 (32%), Gaps = 63/497 (12%)

Query: 4    PRHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINPAAT 63
            P  P  G   + G  G   L  + S +  P     S   S AP       S    +PA+ 
Sbjct: 1004 PPTPSPGPSASPGPPGPA-LTSDSSRELTPHSALTSEATSDAPDT-----SPPTPDPASR 1057

Query: 64   VNDE---SGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVA 120
             N +   +  D  +S  +  SS     + E    P+   P       ST   V S +P +
Sbjct: 1058 TNPDLILTSPDFALSTPD--SSVVPALTPEPSPTPLPTLPKELTSDPSTPSEVTSLSPTS 1115

Query: 121  VTAPPAHLTP---AVPLS--FSEGLMKPPPKP----------TMPSRPIAPAPPS----- 160
               P +  TP     P S   SE    P P P          TM   PI    P+     
Sbjct: 1116 EQVPESDTTPDLDTTPYSSTVSEYSRSPDPSPSPHPTTTPDPTMAPDPITTLNPTVTPHF 1175

Query: 161  -TLSLPPKVPGQVTVTMESSIPQASAIP----VATISGQQGHPSNLHHIMTTNVQMSIIR 215
             T   P   P   T+T  + IP  +  P      T S     P+      TT    +   
Sbjct: 1176 PTTPHPTTTPHPTTITHSTMIPDPTTTPQPFTTITHSTMIPDPTTTPQPFTTMQPTTTPH 1235

Query: 216  SNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQS 275
            S  P P      + +          ++ +  T ++PT+      T  P      H     
Sbjct: 1236 STTPHPTTTPHPTTITHSTMIPDPTTTPQPFTTMQPTTMPHPTTTPHPTTTP--HPTTTP 1293

Query: 276  RPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTL-SIQHPPSAAISIQR 334
             P  T    + P    T   T    P  TTT    T    S P + ++  P S    +  
Sbjct: 1294 HPTTTPHPTMTPDPTTTPYPTTTPDP--TTTPHPTTPDPSSTPVITTVSLPTSLGTELSS 1351

Query: 335  PAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAP---ILATNTIPS 391
            P  +  V   +    HP L       HT   +    T  P  A   +P     AT+  P 
Sbjct: 1352 PTLAPTVKPSL----HPQLTFTAPAPHTSTSQ--IPTLEPSPALESSPSRSSTATSMDPL 1405

Query: 392  ATTAGSVSHTQAPTSTIVTMTVPSHSSH-ATAVTTSNIPVAKVVPQQITHTSPRIQPDYP 450
            +T       +Q+P  T      P+H+ H A+ +T S  P+       + H         P
Sbjct: 1406 STEDFKPPRSQSPNLT----PPPTHTPHSASDLTVSPDPLLSPTAHPLDHP--------P 1453

Query: 451  AERSSLIPISGHRASPN 467
             +  +L P  G    P+
Sbjct: 1454 LDPLTLGPTPGQSPGPH 1470



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 56/237 (23%), Positives = 72/237 (30%), Gaps = 40/237 (16%)

Query: 100  PYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPK----------PTM 149
            P P   M  T     + TP   T P    TP  P +     M P P           PT 
Sbjct: 1263 PQPFTTMQPTTMPHPTTTPHPTTTPHPTTTPH-PTTTPHPTMTPDPTTTPYPTTTPDPTT 1321

Query: 150  PSRPIAPAPPST-----LSLP-----------------PKVPGQVTVTMESSIPQASAIP 187
               P  P P ST     +SLP                 P +  Q+T T  +     S IP
Sbjct: 1322 TPHPTTPDPSSTPVITTVSLPTSLGTELSSPTLAPTVKPSLHPQLTFTAPAPHTSTSQIP 1381

Query: 188  VATISGQQGHPSNLHHIMTTNVQMSIIRSNAP---GPPLHIGASHLPRGAAAAAVMSSSK 244
                S       +     T+   +S      P    P L    +H P  A+   V     
Sbjct: 1382 TLEPSPALESSPSRSSTATSMDPLSTEDFKPPRSQSPNLTPPPTHTPHSASDLTVSPDPL 1441

Query: 245  VTTVLRPTSQLPNAATA---QPAVQHIIHQP-IQSRPPVTTSNAIPPAVVATVSATR 297
            ++    P    P         P      H P +   PPV      PPA+V  V+A R
Sbjct: 1442 LSPTAHPLDHPPLDPLTLGPTPGQSPGPHGPCVAPTPPVRVMACEPPALVELVAAVR 1498


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.124    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,727,311
Number of Sequences: 37866
Number of extensions: 2651103
Number of successful extensions: 26506
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 205
Number of HSP's successfully gapped in prelim test: 1186
Number of HSP's that attempted gapping in prelim test: 13320
Number of HSP's gapped (non-prelim): 7320
length of query: 1048
length of database: 18,247,518
effective HSP length: 113
effective length of query: 935
effective length of database: 13,968,660
effective search space: 13060697100
effective search space used: 13060697100
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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