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Search of human proteins with 197313748
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197313748 SET domain containing 2 [Homo sapiens]
(2564 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197313748 SET domain containing 2 [Homo sapiens] 5192 0.0
gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 203 2e-51
gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 203 2e-51
gi|19913348 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 203 2e-51
gi|109633019 Wolf-Hirschhorn syndrome candidate 1 protein isofor... 203 2e-51
gi|13699811 WHSC1L1 protein isoform long [Homo sapiens] 194 7e-49
gi|27477095 nuclear receptor binding SET domain protein 1 isofor... 185 4e-46
gi|19923586 nuclear receptor binding SET domain protein 1 isofor... 185 4e-46
gi|110349788 absent, small, or homeotic 1-like [Homo sapiens] 175 5e-43
gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens] 104 1e-21
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 100 3e-20
gi|194306650 SET domain and mariner transposase fusion [Homo sap... 100 3e-20
gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens] 99 5e-20
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 99 5e-20
gi|23510384 enhancer of zeste 2 isoform b [Homo sapiens] 98 1e-19
gi|21361095 enhancer of zeste 2 isoform a [Homo sapiens] 98 1e-19
gi|19923202 enhancer of zeste homolog 1 [Homo sapiens] 96 3e-19
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [... 93 4e-18
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 90 3e-17
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 90 3e-17
gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo s... 89 4e-17
gi|210032580 SET domain containing 1B [Homo sapiens] 88 9e-17
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 87 2e-16
gi|55741677 SET domain containing 1A [Homo sapiens] 86 5e-16
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 86 6e-16
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap... 72 7e-12
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap... 72 7e-12
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 71 2e-11
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 69 6e-11
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 68 1e-10
>gi|197313748 SET domain containing 2 [Homo sapiens]
Length = 2564
Score = 5192 bits (13468), Expect = 0.0
Identities = 2564/2564 (100%), Positives = 2564/2564 (100%)
Query: 1 MKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTK 60
MKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTK
Sbjct: 1 MKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTK 60
Query: 61 TKVNLEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEI 120
TKVNLEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEI
Sbjct: 61 TKVNLEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEI 120
Query: 121 GDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPAVIAES 180
GDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPAVIAES
Sbjct: 121 GDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPAVIAES 180
Query: 181 TTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKE 240
TTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKE
Sbjct: 181 TTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKE 240
Query: 241 PPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISL 300
PPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISL
Sbjct: 241 PPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISL 300
Query: 301 SCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKS 360
SCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKS
Sbjct: 301 SCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKS 360
Query: 361 EDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYS 420
EDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYS
Sbjct: 361 EDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYS 420
Query: 421 RSERSHYYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSY 480
RSERSHYYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSY
Sbjct: 421 RSERSHYYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSY 480
Query: 481 RDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFR 540
RDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFR
Sbjct: 481 RDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFR 540
Query: 541 RGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSEL 600
RGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSEL
Sbjct: 541 RGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSEL 600
Query: 601 RMINKNPEREKAGSPAPSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKN 660
RMINKNPEREKAGSPAPSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKN
Sbjct: 601 RMINKNPEREKAGSPAPSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKN 660
Query: 661 DQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSELSPLVKACMLSSNG 720
DQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSELSPLVKACMLSSNG
Sbjct: 661 DQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSELSPLVKACMLSSNG 720
Query: 721 FQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVD 780
FQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVD
Sbjct: 721 FQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVD 780
Query: 781 TRVSCCKTKDSDIYCTLNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRN 840
TRVSCCKTKDSDIYCTLNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRN
Sbjct: 781 TRVSCCKTKDSDIYCTLNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRN 840
Query: 841 LTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKC 900
LTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKC
Sbjct: 841 LTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKC 900
Query: 901 GENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQ 960
GENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQ
Sbjct: 901 GENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQ 960
Query: 961 EAQEEGNSILPERRGRPEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALK 1020
EAQEEGNSILPERRGRPEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALK
Sbjct: 961 EAQEEGNSILPERRGRPEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALK 1020
Query: 1021 CDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPM 1080
CDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPM
Sbjct: 1021 CDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPM 1080
Query: 1081 EETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKN 1140
EETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKN
Sbjct: 1081 EETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKN 1140
Query: 1141 PEISFTQSSRKQIDNRLPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQE 1200
PEISFTQSSRKQIDNRLPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQE
Sbjct: 1141 PEISFTQSSRKQIDNRLPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQE 1200
Query: 1201 ELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGW 1260
ELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGW
Sbjct: 1201 ELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGW 1260
Query: 1261 DFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVY 1320
DFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVY
Sbjct: 1261 DFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVY 1320
Query: 1321 DRTQGQVPDSLTDDREEEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDT 1380
DRTQGQVPDSLTDDREEEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDT
Sbjct: 1321 DRTQGQVPDSLTDDREEEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDT 1380
Query: 1381 LAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPP 1440
LAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPP
Sbjct: 1381 LAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPP 1440
Query: 1441 GSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCE 1500
GSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCE
Sbjct: 1441 GSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCE 1500
Query: 1501 CTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKK 1560
CTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKK
Sbjct: 1501 CTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKK 1560
Query: 1561 GWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQK 1620
GWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQK
Sbjct: 1561 GWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQK 1620
Query: 1621 GNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFC 1680
GNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFC
Sbjct: 1621 GNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFC 1680
Query: 1681 GSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSR 1740
GSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSR
Sbjct: 1681 GSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSR 1740
Query: 1741 LMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEEI 1800
LMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEEI
Sbjct: 1741 LMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEEI 1800
Query: 1801 IKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDP 1860
IKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDP
Sbjct: 1801 IKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDP 1860
Query: 1861 STKLSTEADTDTPKKLMFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEE 1920
STKLSTEADTDTPKKLMFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEE
Sbjct: 1861 STKLSTEADTDTPKKLMFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEE 1920
Query: 1921 EELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEPKESNGTKLEEPINEETPS 1980
EELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEPKESNGTKLEEPINEETPS
Sbjct: 1921 EELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEPKESNGTKLEEPINEETPS 1980
Query: 1981 QDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKENTTTER 2040
QDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKENTTTER
Sbjct: 1981 QDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKENTTTER 2040
Query: 2041 GRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYD 2100
GRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYD
Sbjct: 2041 GRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYD 2100
Query: 2101 TPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAP 2160
TPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAP
Sbjct: 2101 TPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAP 2160
Query: 2161 HHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTEPLSAP 2220
HHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTEPLSAP
Sbjct: 2161 HHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTEPLSAP 2220
Query: 2221 PPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDSNQQSV 2280
PPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDSNQQSV
Sbjct: 2221 PPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDSNQQSV 2280
Query: 2281 SVQQQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAH 2340
SVQQQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAH
Sbjct: 2281 SVQQQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAH 2340
Query: 2341 PQGVVVQPAAAVTTIVAPGQPQPLQPSEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARD 2400
PQGVVVQPAAAVTTIVAPGQPQPLQPSEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARD
Sbjct: 2341 PQGVVVQPAAAVTTIVAPGQPQPLQPSEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARD 2400
Query: 2401 PEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKASKKPKTAEA 2460
PEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKASKKPKTAEA
Sbjct: 2401 PEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKASKKPKTAEA 2460
Query: 2461 DTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKE 2520
DTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKE
Sbjct: 2461 DTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKE 2520
Query: 2521 LKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPKEDTELE 2564
LKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPKEDTELE
Sbjct: 2521 LKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPKEDTELE 2564
>gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 203 bits (516), Expect = 2e-51
Identities = 99/231 (42%), Positives = 140/231 (60%), Gaps = 14/231 (6%)
Query: 1498 QCECTPLSKDERAQGEIACGED--CLNRLLMIECSSR-CPNGDYCSNRRFQRKQHADVEV 1554
+C C P ++ CG D CLNR+LM EC + CP G++C N+ F ++Q+ + ++
Sbjct: 1015 KCNCKPTDENP-------CGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKI 1067
Query: 1555 ILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEI 1614
I T+ KGWGL A +D+ FV EY GE++D +E AR+K N H+Y + + D I
Sbjct: 1068 IKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRI 1127
Query: 1615 IDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKE 1674
IDA KGN SRFMNHSC+PNCET KWTVNG RVG F +P+G+ELTF+Y G E
Sbjct: 1128 IDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNE 1187
Query: 1675 AQKCFCGSANCRGYLGGENRVSIRAA----GGKMKKERSRKKDSVDGELEA 1721
C CG++NC G+LG + S + G K KK+ R++ +G+ ++
Sbjct: 1188 KTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQS 1238
>gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 203 bits (516), Expect = 2e-51
Identities = 99/231 (42%), Positives = 140/231 (60%), Gaps = 14/231 (6%)
Query: 1498 QCECTPLSKDERAQGEIACGED--CLNRLLMIECSSR-CPNGDYCSNRRFQRKQHADVEV 1554
+C C P ++ CG D CLNR+LM EC + CP G++C N+ F ++Q+ + ++
Sbjct: 1015 KCNCKPTDENP-------CGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKI 1067
Query: 1555 ILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEI 1614
I T+ KGWGL A +D+ FV EY GE++D +E AR+K N H+Y + + D I
Sbjct: 1068 IKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRI 1127
Query: 1615 IDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKE 1674
IDA KGN SRFMNHSC+PNCET KWTVNG RVG F +P+G+ELTF+Y G E
Sbjct: 1128 IDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNE 1187
Query: 1675 AQKCFCGSANCRGYLGGENRVSIRAA----GGKMKKERSRKKDSVDGELEA 1721
C CG++NC G+LG + S + G K KK+ R++ +G+ ++
Sbjct: 1188 KTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQS 1238
>gi|19913348 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 203 bits (516), Expect = 2e-51
Identities = 99/231 (42%), Positives = 140/231 (60%), Gaps = 14/231 (6%)
Query: 1498 QCECTPLSKDERAQGEIACGED--CLNRLLMIECSSR-CPNGDYCSNRRFQRKQHADVEV 1554
+C C P ++ CG D CLNR+LM EC + CP G++C N+ F ++Q+ + ++
Sbjct: 1015 KCNCKPTDENP-------CGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKI 1067
Query: 1555 ILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEI 1614
I T+ KGWGL A +D+ FV EY GE++D +E AR+K N H+Y + + D I
Sbjct: 1068 IKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRI 1127
Query: 1615 IDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKE 1674
IDA KGN SRFMNHSC+PNCET KWTVNG RVG F +P+G+ELTF+Y G E
Sbjct: 1128 IDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNE 1187
Query: 1675 AQKCFCGSANCRGYLGGENRVSIRAA----GGKMKKERSRKKDSVDGELEA 1721
C CG++NC G+LG + S + G K KK+ R++ +G+ ++
Sbjct: 1188 KTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQS 1238
>gi|109633019 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 203 bits (516), Expect = 2e-51
Identities = 99/231 (42%), Positives = 140/231 (60%), Gaps = 14/231 (6%)
Query: 1498 QCECTPLSKDERAQGEIACGED--CLNRLLMIECSSR-CPNGDYCSNRRFQRKQHADVEV 1554
+C C P ++ CG D CLNR+LM EC + CP G++C N+ F ++Q+ + ++
Sbjct: 1015 KCNCKPTDENP-------CGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKI 1067
Query: 1555 ILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEI 1614
I T+ KGWGL A +D+ FV EY GE++D +E AR+K N H+Y + + D I
Sbjct: 1068 IKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRI 1127
Query: 1615 IDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKE 1674
IDA KGN SRFMNHSC+PNCET KWTVNG RVG F +P+G+ELTF+Y G E
Sbjct: 1128 IDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNE 1187
Query: 1675 AQKCFCGSANCRGYLGGENRVSIRAA----GGKMKKERSRKKDSVDGELEA 1721
C CG++NC G+LG + S + G K KK+ R++ +G+ ++
Sbjct: 1188 KTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQS 1238
>gi|13699811 WHSC1L1 protein isoform long [Homo sapiens]
Length = 1437
Score = 194 bits (494), Expect = 7e-49
Identities = 99/240 (41%), Positives = 141/240 (58%), Gaps = 13/240 (5%)
Query: 1486 KKNKSHRDIKRMQCECTPLSKDERAQ----GEIACG--EDCLNRLLMIECSSR-CPNGDY 1538
K K+++ I ++Q + LS+ R E CG +CLNR+L EC + CP GD
Sbjct: 1074 KHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDR 1133
Query: 1539 CSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYAR 1598
C N+ F ++ + D E+I TE++GWGLR + + FV EY GE++D +E + R+K
Sbjct: 1134 CQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHE 1193
Query: 1599 NKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPS 1658
N ++Y + + D IIDA KGN SRFMNHSC PNCETQKWTVNG +RVG F +P+
Sbjct: 1194 NSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPA 1253
Query: 1659 GSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSI------RAAGGKMKKERSRKK 1712
G ELTF+Y G +C CG+ NC G+LG + + +A K+K++R + K
Sbjct: 1254 GMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIK 1313
>gi|27477095 nuclear receptor binding SET domain protein 1 isoform a
[Homo sapiens]
Length = 2427
Score = 185 bits (470), Expect = 4e-46
Identities = 101/244 (41%), Positives = 143/244 (58%), Gaps = 11/244 (4%)
Query: 1486 KKNKSHRDIKRMQCECTPLSKDER----AQGEIACGED--CLNRLLMIECSSR-CPNGDY 1538
K K +R I R+Q LS+ R A E CG D C+NR+L+ EC CP G
Sbjct: 1602 KHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGR 1661
Query: 1539 CSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYAR 1598
C N+ F ++Q+ +VE+ T ++GWGLR D+ FV EY GE++D +E +AR++ YA+
Sbjct: 1662 CQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIR-YAQ 1720
Query: 1599 NKNI-HYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVP 1657
+I ++Y + L D IIDA KGN +RFMNH C+PNCETQKW+VNG RVG F +
Sbjct: 1721 EHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIK 1780
Query: 1658 SGSELTFDYQFQRYGKEAQKCFCGSANCRGYLG--GENRVSIRAAGGKMKKERSRKKDSV 1715
+G+ELTF+Y + G C CG+ NC G+LG +N+ K K++ + K
Sbjct: 1781 AGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT 1840
Query: 1716 DGEL 1719
GE+
Sbjct: 1841 QGEI 1844
>gi|19923586 nuclear receptor binding SET domain protein 1 isoform b
[Homo sapiens]
Length = 2696
Score = 185 bits (470), Expect = 4e-46
Identities = 101/244 (41%), Positives = 143/244 (58%), Gaps = 11/244 (4%)
Query: 1486 KKNKSHRDIKRMQCECTPLSKDER----AQGEIACGED--CLNRLLMIECSSR-CPNGDY 1538
K K +R I R+Q LS+ R A E CG D C+NR+L+ EC CP G
Sbjct: 1871 KHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGR 1930
Query: 1539 CSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYAR 1598
C N+ F ++Q+ +VE+ T ++GWGLR D+ FV EY GE++D +E +AR++ YA+
Sbjct: 1931 CQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIR-YAQ 1989
Query: 1599 NKNI-HYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVP 1657
+I ++Y + L D IIDA KGN +RFMNH C+PNCETQKW+VNG RVG F +
Sbjct: 1990 EHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIK 2049
Query: 1658 SGSELTFDYQFQRYGKEAQKCFCGSANCRGYLG--GENRVSIRAAGGKMKKERSRKKDSV 1715
+G+ELTF+Y + G C CG+ NC G+LG +N+ K K++ + K
Sbjct: 2050 AGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT 2109
Query: 1716 DGEL 1719
GE+
Sbjct: 2110 QGEI 2113
>gi|110349788 absent, small, or homeotic 1-like [Homo sapiens]
Length = 2964
Score = 175 bits (444), Expect = 5e-43
Identities = 109/311 (35%), Positives = 165/311 (53%), Gaps = 29/311 (9%)
Query: 1403 PLKKRRQ------EIESDSESDGELQDRKKVRVEVEQGETSVP--PGSALVGPSCVMD-- 1452
P KK+ Q ++ ++ L KK ++E GE P VG
Sbjct: 1984 PPKKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVGKYLRQKRI 2043
Query: 1453 DFRDPQ----RWK--ECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSK 1506
DF+ P +WK + K+ +P Y I NVY+ + + + C C
Sbjct: 2044 DFQLPYDILWQWKHNQLYKKPDVPLY-KKIRSNVYVDVKPLS----GYEATTCNCKKPDD 2098
Query: 1507 DERAQGEIACGEDCLNRLLMIECS-SRCPNGDYCSNRRFQRKQHAD-VEVILTEKKGWGL 1564
D R C +DCLNR++ ECS + CP G+ C N+R QR + +E E+KGWG+
Sbjct: 2099 DTRK----GCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGI 2154
Query: 1565 RAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCS 1624
R + L + F++EY GEV+ +EF+ R+ E N + HY + L + +ID+ + GN +
Sbjct: 2155 RTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYC-LNLDSGMVIDSYRMGNEA 2213
Query: 1625 RFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQK-CFCGSA 1683
RF+NHSC+PNCE QKW+VNG R+G + K +P+G+ELT+DY F + E Q+ C CG
Sbjct: 2214 RFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFE 2273
Query: 1684 NCRGYLGGENR 1694
CRG +GG+++
Sbjct: 2274 KCRGIIGGKSQ 2284
Score = 33.5 bits (75), Expect = 2.8
Identities = 58/262 (22%), Positives = 99/262 (37%), Gaps = 36/262 (13%)
Query: 887 PPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASR 946
P + V ++T C + S +L L S S +K + E + + + K A++
Sbjct: 1762 PDSLLVPAVTSDSCNNSIS-LLSEKLTSSCSPHHIKRSVVEAMQRQARKMCNYDKILATK 1820
Query: 947 EN--RRNNGLSGKCLQEAQEEGNSILPERRGR----------------------PEISLD 982
+N N L K LQ GN+ + R GR PE++ D
Sbjct: 1821 KNLDHVNKILKAKKLQRQARTGNNFVKRRPGRPRKCPLQAVVSMQAFQAAQFVNPELNRD 1880
Query: 983 ERGEGGHVHTSDDSEVVFSSC-DLNLTMEDSDGVT---YALKCDSSGHAPEIVSTVHEDY 1038
E G H+ ++V+ + +NL E G+ + L+ + + ++
Sbjct: 1881 EEGAALHLSPDTVTDVIEAVVQSVNLNPEHKKGLKRKGWLLEEQTRKKQKPLPEEEEQEN 1940
Query: 1039 SGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSS-QSYRHY 1097
+ S + E S S P + LQ V+ S +P E+ P + Q Y
Sbjct: 1941 NKSFNEAPVEIPSPSETPAKPSEPESTLQPVL-----SLIPREKKPPRPPKKKYQKAGLY 1995
Query: 1098 SDHWEDERLESRR-HLYEEKFE 1118
SD ++ +SR L +EK E
Sbjct: 1996 SDVYKTTDPKSRLIQLKKEKLE 2017
Score = 33.1 bits (74), Expect = 3.6
Identities = 32/108 (29%), Positives = 45/108 (41%), Gaps = 15/108 (13%)
Query: 101 PNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATT 160
P+ P PL P +K + G PPK R + ++ F +H S PL +T
Sbjct: 1331 PSFPLDPLHYIRKPDLKKKRG---------RPPKMREAMAEMPF----MHSLSFPLSSTG 1377
Query: 161 TAVA-SPPTHAAPLPAV-IAESTTVDSPPSSPPPPPPPAQATTLSSPA 206
+ P +PL A I PP+ PPPP P+ T L P+
Sbjct: 1378 FYPSYGMPYSPSPLTAAPIGLGYYGRYPPTLYPPPPSPSFTTPLPPPS 1425
>gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens]
Length = 350
Score = 104 bits (259), Expect = 1e-21
Identities = 65/183 (35%), Positives = 97/183 (53%), Gaps = 22/183 (12%)
Query: 1528 ECSSRCPNGDYCSNRRFQRKQHADVEVILTEK-KGWGLRAAKDLPSNTFVLEYCGEVLDH 1586
EC+SRC G C NR Q+ + + T +GWG++ + +FV+EY GEV+
Sbjct: 168 ECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITS 227
Query: 1587 KEFKARVKEYARNKNIHYYF-MALKNDEI-IDATQKGNCSRFMNHSCEPNCETQKWTVNG 1644
+E + R + Y NK I Y F + ++DE +DA + GN S F+NHSC+PN + ++
Sbjct: 228 EEAERRGQFY-DNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDN 286
Query: 1645 ----QLRVGFFTTKLVPSGSELTFDYQFQRYG---------KEAQK-----CFCGSANCR 1686
R+ F+T+ + +G ELTFDYQ + G A+K C CG+ CR
Sbjct: 287 LDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCR 346
Query: 1687 GYL 1689
GYL
Sbjct: 347 GYL 349
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1 isoform
1 [Homo sapiens]
Length = 1298
Score = 99.8 bits (247), Expect = 3e-20
Identities = 69/208 (33%), Positives = 98/208 (47%), Gaps = 24/208 (11%)
Query: 1493 DIKRMQCECTPLS------KDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQR 1546
D C C LS KD R E E L + EC+ C C NR Q
Sbjct: 1067 DCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPL----IFECNHACSCWRNCRNRVVQN 1122
Query: 1547 KQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYF 1606
A +++ T GWG+R+ +D+P TFV EY GE++ E R ++ + +
Sbjct: 1123 GLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEAD------VREEDSYLFD 1176
Query: 1607 MALKNDEI--IDATQKGNCSRFMNHSCEPNCETQKWTVNGQ----LRVGFFTTKLVPSGS 1660
+ K+ E+ IDA GN SRF+NH CEPN + + Q R+ FF+T+L+ +G
Sbjct: 1177 LDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGE 1236
Query: 1661 ELTFDY--QFQRYGKEAQKCFCGSANCR 1686
+L FDY +F + C CGS CR
Sbjct: 1237 QLGFDYGERFWDIKGKLFSCRCGSPKCR 1264
Score = 32.0 bits (71), Expect = 8.1
Identities = 77/378 (20%), Positives = 134/378 (35%), Gaps = 55/378 (14%)
Query: 153 SRPLLATTTAVASPPTHAA-PLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEP 211
++PL T+T +S P HAA LP + T + P +P PP TL + TE
Sbjct: 134 AQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPP-----ATLGEGSADTED 188
Query: 212 VALPHTPITVLMAAPVPLPVDVAV-RSLKEPPIIIVPESLEADTKQDTISNSLEEHVTQI 270
LP AP DV V R+ K P +V L A +K +H
Sbjct: 189 RKLP---------AP---GADVKVHRARKTMPKSVV--GLHAASKDPREVREARDH---- 230
Query: 271 LNEQADISSKKEDSHIGKDEEIPDSSKISLS-----CKKTGSKKKSSQSEGIFLGSESDE 325
++ K S G+ + +P + S C +K +++ + + S +
Sbjct: 231 --KEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRK 288
Query: 326 DSVRTSS-----SQRSHDLKFSASIEKERDFKKSSAPLKSE-DLGKPS--------RSKT 371
R + +++ LK IE + S+ K E DLG S +
Sbjct: 289 KKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDS 348
Query: 372 DRDDKYFSYSKLERDTRYVSSRCR---SERERRRSRSHSRSERGSRTNLSYSRSERSHYY 428
D DD +LE D + + + +E R S S ++R + + + S
Sbjct: 349 DEDDS----EELEEDDGHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDT 404
Query: 429 DSDRRYHRSSPYRERTRYSRPYTDNRARESSD--SEEEYKKTYSRRTSSHSSSYRDLRTS 486
+ S + + + + + S ++ SR+ S + ++S
Sbjct: 405 GEEEEGGDESDLSSESSIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSS 464
Query: 487 SYSKSDRDCKTETSYLEM 504
+ S T Y+E+
Sbjct: 465 AGSAEQTAPGDSTGYMEV 482
>gi|194306650 SET domain and mariner transposase fusion [Homo sapiens]
Length = 684
Score = 99.8 bits (247), Expect = 3e-20
Identities = 57/186 (30%), Positives = 90/186 (48%), Gaps = 24/186 (12%)
Query: 1526 MIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLD 1585
+ EC+ C D+C NR Q+ +V T KKGWGLR + +P FV EY GEVL
Sbjct: 115 VFECNVLCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLG 174
Query: 1586 HKEFKARVKEYARNKNIHYYFMALKN--------DEIIDATQKGNCSRFMNHSCEPNCET 1637
E + R+ + + K+ Y +A++ + +D T GN RF+NHSCEPN
Sbjct: 175 FSEVQRRI--HLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLM 232
Query: 1638 QKWTVNGQL-RVGFFTTKLVPSGSELTFDYQFQ-------------RYGKEAQKCFCGSA 1683
++ + ++ F K + EL++DY + +GK + C+CG+
Sbjct: 233 IPVRIDSMVPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAK 292
Query: 1684 NCRGYL 1689
+C +L
Sbjct: 293 SCTAFL 298
>gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens]
Length = 412
Score = 99.0 bits (245), Expect = 5e-20
Identities = 61/195 (31%), Positives = 96/195 (49%), Gaps = 29/195 (14%)
Query: 1524 LLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEK-KGWGLRAAKDLPSNTFVLEYCGE 1582
L + EC+SRC G C NR Q+ D+ + T+ +GWG+R + + N+FV+EY GE
Sbjct: 217 LPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGE 276
Query: 1583 VLDHKEFKARVKEYARNKNIHYYFMALKND-EIIDATQKGNCSRFMNHSCEPNCETQKWT 1641
++ +E + R + Y R + + + D +DA GN S F+NHSC+PN +
Sbjct: 277 IITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVF 336
Query: 1642 VNG----QLRVGFFTTKLVPSGSELTFDYQFQ-------------RYG----------KE 1674
++ R+ FF T+ + +G ELTFDY Q +G +
Sbjct: 337 IDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRV 396
Query: 1675 AQKCFCGSANCRGYL 1689
+C CG+ +CR YL
Sbjct: 397 RIECKCGTESCRKYL 411
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 99.0 bits (245), Expect = 5e-20
Identities = 51/149 (34%), Positives = 85/149 (57%), Gaps = 2/149 (1%)
Query: 1542 RRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKN 1601
RR + + +V + + +G GL AAKDL +T V+EY G ++ ++ R K Y +N
Sbjct: 5389 RRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIY-EEQN 5447
Query: 1602 IHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSE 1661
Y + N+ +IDAT G +R++NHSC PNC + T + + ++ +++ +P G E
Sbjct: 5448 RGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEE 5507
Query: 1662 LTFDYQFQRYGKEAQ-KCFCGSANCRGYL 1689
LT+DYQF + + C CG+ NCR ++
Sbjct: 5508 LTYDYQFDFEDDQHKIPCHCGAWNCRKWM 5536
Score = 42.7 bits (99), Expect = 0.005
Identities = 44/163 (26%), Positives = 64/163 (39%), Gaps = 24/163 (14%)
Query: 165 SPPTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMA 224
SPP +PL ES T P +S PPP T SP P P + P P LM+
Sbjct: 663 SPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPT---SPPPEDSPASPP--PEDSLMS 717
Query: 225 APVPLPVDVAVRSLKEPPIIIVPESLEADTKQD--TISNSLEEHVTQILNEQADISSKKE 282
P L+E P++ +PE + + + +S EE E+ +S + E
Sbjct: 718 LP-----------LEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAE 766
Query: 283 DSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDE 325
+ H+ E P C S Q+EG L + +E
Sbjct: 767 EPHLSPQPEEP------CLCAVPEEPHLSPQAEGPHLSPQPEE 803
Score = 37.4 bits (85), Expect = 0.19
Identities = 34/133 (25%), Positives = 55/133 (41%), Gaps = 12/133 (9%)
Query: 165 SPPTH---AAPLPAVIAESTTVDSPPSSPPP------PPPPAQATTLSSPAPVTEPVALP 215
SPP A+PLP + S ++ P SPPP PPP + + +P++ P P
Sbjct: 468 SPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESP 527
Query: 216 HTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQDT--ISNSLEEHVTQILNE 273
+P +P P ++ +E P+ PE L + +S EE E
Sbjct: 528 PSPALETPLSPPPEASPLS-PPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPE 586
Query: 274 QADISSKKEDSHI 286
++ +S E S +
Sbjct: 587 ESPMSPPPEASRL 599
Score = 36.6 bits (83), Expect = 0.33
Identities = 31/98 (31%), Positives = 42/98 (42%), Gaps = 5/98 (5%)
Query: 156 LLATTTAVASPPT-HAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEP-VA 213
LL + PPT H+ + + +PP P PPP A + +SP TEP V
Sbjct: 4878 LLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPP--TEPLVE 4935
Query: 214 LPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLE 251
LP P+ P PLP+ + S + P PE E
Sbjct: 4936 LPTEPLAE-PPVPSPLPLASSPESARPKPRARPPEEGE 4972
Score = 35.8 bits (81), Expect = 0.56
Identities = 35/165 (21%), Positives = 65/165 (39%), Gaps = 20/165 (12%)
Query: 2133 EAQKQQQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKV----- 2187
E Q+Q+Q+++ L + + ++L A G P +PS+P ++
Sbjct: 2678 EKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQT 2737
Query: 2188 -LLPTPSMDPVCSPAPYDHAQPLVGHSTEP----LSAPPPVPVVPHVAAPVEVSSSQYVA 2242
T + P + P++G + P LS PPP P + ++V+S Q V
Sbjct: 2738 PFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPP----PATPSSMDVNSRQLVG 2793
Query: 2243 QSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDSNQQSVSVQQQYS 2287
S + P P P+Q Q +W Q + + +++
Sbjct: 2794 GSQAFYQR------APYPGSLPLQQQQQQLWQQQQATAATSMRFA 2832
Score = 35.0 bits (79), Expect = 0.95
Identities = 36/125 (28%), Positives = 46/125 (36%), Gaps = 14/125 (11%)
Query: 94 NEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTS 153
NE+ P P PL +P + A SPP + + HL S
Sbjct: 435 NEEMPLLPPPEESPL----SPPPEESPTSPPPEASRLSPPPEELPASPLPEALHL----S 486
Query: 154 RPLLATTTAVASPPTHAAPL---PAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTE 210
RPL + SPP +PL P S +SP S P PP T SP P
Sbjct: 487 RPL---EESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEAS 543
Query: 211 PVALP 215
P++ P
Sbjct: 544 PLSPP 548
Score = 35.0 bits (79), Expect = 0.95
Identities = 53/251 (21%), Positives = 95/251 (37%), Gaps = 33/251 (13%)
Query: 2188 LLPTPSMDPVCSPAPYDHAQPLVGHSTEPLSAPP------PVPVVPHVAAPVEVSSSQYV 2241
LLP P P+ P P S LS PP P+P H++ P+E S
Sbjct: 440 LLPPPEESPLSPPPEESPTSPPPEASR--LSPPPEELPASPLPEALHLSRPLEESPLSPP 497
Query: 2242 AQSDGVVHQDSSVAVLPVPAP-GPVQGQNYSVWDSNQQSVSVQQQYSPAQSQATIYYQGQ 2300
+ +S ++ P +P P++ S + + S +++ SP + + +
Sbjct: 498 PE-------ESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFE 550
Query: 2301 TCPTVYGVTSPYSQ--TTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTTIVAP 2358
P ++ P + T+PP S P + + + P+ + P + + P
Sbjct: 551 ESP----LSPPPEELPTSPPPEASRLSPPPE----ESPMSPPPEESPMSPPPEASRLFPP 602
Query: 2359 GQPQPLQPSEMVVTNNLLDLPPP----SPPKPKTIVLPPNWKTARDPEGKIYYYHVITRQ 2414
+ PL P + L PP SPP + + PP ++ P ++ +
Sbjct: 603 FEESPLSPPP---EESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVV 659
Query: 2415 TQWDPPTWESP 2425
++ PP ESP
Sbjct: 660 SRLSPPPEESP 670
Score = 34.3 bits (77), Expect = 1.6
Identities = 56/223 (25%), Positives = 79/223 (35%), Gaps = 20/223 (8%)
Query: 2199 SPAPYDHAQPLVGHSTEPLSAPPPV--PVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAV 2256
S P+ AQP V +P S + P P + P++ ++ + V+ +
Sbjct: 4128 SSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPG 4187
Query: 2257 LPV-PAPGPVQGQNYSVWDSNQQ----SVSVQQQYSPAQSQATIYYQGQTCPTVYGVTSP 2311
+ + P G ++ Q V N Q S QQQ Q + Q Q P
Sbjct: 4188 VGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQ-QSQAVRQTPPYQEP 4246
Query: 2312 YSQTTPPIVQSYAQPSLQYIQGQQIFTAH-------PQGVVVQPA--AAVTT--IVAPGQ 2360
+QT+P QP L G Q PQG PA A++T ++ P
Sbjct: 4247 GTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVH 4306
Query: 2361 PQPLQPSEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARDPEG 2403
P P PS LP PS P LPP P+G
Sbjct: 4307 PTP-PPSSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQG 4348
Score = 33.9 bits (76), Expect = 2.1
Identities = 39/126 (30%), Positives = 48/126 (38%), Gaps = 26/126 (20%)
Query: 165 SPPTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMA 224
SPP A+ L ES P SP PPP A SP P P++ P P M+
Sbjct: 591 SPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRL---SPPPEDSPMSPP--PEESPMS 645
Query: 225 AP------VPLPVDVAVRSLKEPPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADIS 278
P PLPV V L PP ++ +S EE T E + +S
Sbjct: 646 PPPEVSRLSPLPV---VSRLSPPP------------EESPLSPPPEESPTSPPPEASRLS 690
Query: 279 SKKEDS 284
EDS
Sbjct: 691 PPPEDS 696
Score = 32.3 bits (72), Expect = 6.2
Identities = 34/125 (27%), Positives = 50/125 (40%), Gaps = 12/125 (9%)
Query: 131 SPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVA--SPPTHA---APLPAVIAESTTVDS 185
SP + L + HL V P L+ + SP + +P P S ++
Sbjct: 798 SPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEK 857
Query: 186 PPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIII 245
PP SP P PP + PAP P+ P ++ PL + A+ EPP+
Sbjct: 858 PPLSPRPEKPPEEPG--QCPAPEELPLFPPPGEPSL-----SPLLGEPALSEPGEPPLSP 910
Query: 246 VPESL 250
+PE L
Sbjct: 911 LPEEL 915
>gi|23510384 enhancer of zeste 2 isoform b [Homo sapiens]
Length = 707
Score = 97.8 bits (242), Expect = 1e-19
Identities = 48/132 (36%), Positives = 71/132 (53%), Gaps = 2/132 (1%)
Query: 1539 CSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYAR 1598
C N QR + + ++ GWG+ + N F+ EYCGE++ E R K Y
Sbjct: 562 CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVY-- 619
Query: 1599 NKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPS 1658
+K + + L ND ++DAT+KGN RF NHS PNC + VNG R+G F + + +
Sbjct: 620 DKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT 679
Query: 1659 GSELTFDYQFQR 1670
G EL FDY++ +
Sbjct: 680 GEELFFDYRYSQ 691
>gi|21361095 enhancer of zeste 2 isoform a [Homo sapiens]
Length = 751
Score = 97.8 bits (242), Expect = 1e-19
Identities = 48/132 (36%), Positives = 71/132 (53%), Gaps = 2/132 (1%)
Query: 1539 CSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYAR 1598
C N QR + + ++ GWG+ + N F+ EYCGE++ E R K Y
Sbjct: 606 CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVY-- 663
Query: 1599 NKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPS 1658
+K + + L ND ++DAT+KGN RF NHS PNC + VNG R+G F + + +
Sbjct: 664 DKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT 723
Query: 1659 GSELTFDYQFQR 1670
G EL FDY++ +
Sbjct: 724 GEELFFDYRYSQ 735
>gi|19923202 enhancer of zeste homolog 1 [Homo sapiens]
Length = 747
Score = 96.3 bits (238), Expect = 3e-19
Identities = 48/132 (36%), Positives = 71/132 (53%), Gaps = 2/132 (1%)
Query: 1539 CSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYAR 1598
C N QR + + ++ GWG + + N F+ EYCGE++ E R K Y
Sbjct: 602 CKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVY-- 659
Query: 1599 NKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPS 1658
+K + + L ND ++DAT+KGN RF NHS PNC + VNG R+G F + + +
Sbjct: 660 DKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQA 719
Query: 1659 GSELTFDYQFQR 1670
G EL FDY++ +
Sbjct: 720 GEELFFDYRYSQ 731
>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
sapiens]
Length = 3969
Score = 92.8 bits (229), Expect = 4e-18
Identities = 49/149 (32%), Positives = 77/149 (51%), Gaps = 2/149 (1%)
Query: 1542 RRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKN 1601
R ++ V V + G GL +++ + V+EY G V+ + R K Y +K
Sbjct: 3821 RHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYD-SKG 3879
Query: 1602 IHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSE 1661
I Y + + E++DAT GN +RF+NHSCEPNC ++ ++GQ + F + + G E
Sbjct: 3880 IGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEE 3939
Query: 1662 LTFDYQFQ-RYGKEAQKCFCGSANCRGYL 1689
LT+DY+F C CG+ CR +L
Sbjct: 3940 LTYDYKFPIEDASNKLPCNCGAKKCRKFL 3968
Score = 32.3 bits (72), Expect = 6.2
Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 6/98 (6%)
Query: 2029 SQTEKENTTTERGRDAVGFRDQTPA---PKTPNRSRERDPD-KQTQNKEKRKRRSSLSPP 2084
SQTE+ + + RD + K+ R RER+ + K+ KEKRK+ S +
Sbjct: 843 SQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQSS 902
Query: 2085 SSAYERG--TKRPDDRYDTPTSKKKVRIKDRNKLSTEE 2120
S+ Y G +K D TS + R K S+ +
Sbjct: 903 SALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHD 940
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2 isoform
b [Homo sapiens]
Length = 1176
Score = 89.7 bits (221), Expect = 3e-17
Identities = 55/170 (32%), Positives = 87/170 (51%), Gaps = 14/170 (8%)
Query: 1525 LMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVL 1584
L+ EC+ C C NR Q +++ T K GWG+RA + +P TF+ EY GE++
Sbjct: 979 LIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELI 1038
Query: 1585 DHKEFKARVKEYARNKNIHYYFMALKNDEI--IDATQKGNCSRFMNHSCEPN-CETQKWT 1641
E R + + + + K+ E+ IDA GN SRF+NH C+PN + +
Sbjct: 1039 SDAEAD------VREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFM 1092
Query: 1642 VNGQL---RVGFFTTKLVPSGSELTFDY--QFQRYGKEAQKCFCGSANCR 1686
++ L R+ FF+++ + +G EL FDY +F + C CGS C+
Sbjct: 1093 LHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCK 1142
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2 isoform
a [Homo sapiens]
Length = 1210
Score = 89.7 bits (221), Expect = 3e-17
Identities = 55/170 (32%), Positives = 87/170 (51%), Gaps = 14/170 (8%)
Query: 1525 LMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVL 1584
L+ EC+ C C NR Q +++ T K GWG+RA + +P TF+ EY GE++
Sbjct: 1013 LIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELI 1072
Query: 1585 DHKEFKARVKEYARNKNIHYYFMALKNDEI--IDATQKGNCSRFMNHSCEPN-CETQKWT 1641
E R + + + + K+ E+ IDA GN SRF+NH C+PN + +
Sbjct: 1073 SDAEAD------VREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFM 1126
Query: 1642 VNGQL---RVGFFTTKLVPSGSELTFDY--QFQRYGKEAQKCFCGSANCR 1686
++ L R+ FF+++ + +G EL FDY +F + C CGS C+
Sbjct: 1127 LHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCK 1176
>gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo
sapiens]
Length = 4911
Score = 89.4 bits (220), Expect = 4e-17
Identities = 45/149 (30%), Positives = 83/149 (55%), Gaps = 2/149 (1%)
Query: 1542 RRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKN 1601
R+ + + ++V + + +G GL AA+D+ +T V+EY G ++ ++ + K Y ++N
Sbjct: 4763 RKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLY-ESQN 4821
Query: 1602 IHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSE 1661
Y + ND +IDAT G +R++NHSC PNC + T ++ +++ + G E
Sbjct: 4822 RGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKGEE 4881
Query: 1662 LTFDYQFQRYGKEAQ-KCFCGSANCRGYL 1689
L +DY+F + + C CG+ NCR ++
Sbjct: 4882 LCYDYKFDFEDDQHKIPCHCGAVNCRKWM 4910
Score = 45.4 bits (106), Expect = 7e-04
Identities = 62/281 (22%), Positives = 116/281 (41%), Gaps = 26/281 (9%)
Query: 1834 VPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKLMFRRLKIISENSMDSAI 1893
VPP + G+S ++S LN P T P + L+I ++ S +
Sbjct: 2628 VPPSQQEQGHSVHSSSMVMRTLNHPLGGEFSEAPLSTSVPSETTSDNLQITTQPS--DGL 2685
Query: 1894 SDATSELEGKDGKEDLDQLENVPVE--EEEELQSQQLLPQQLPECKVDSETNIEASK--- 1948
+ + + D+ LE V V+ ++E+L++ L + ++D+ N+E +
Sbjct: 2686 EEKLDSDDPSVKELDVKDLEGVEVKDLDDEDLENLNLDTEDGKVVELDTLDNLETNDPNL 2745
Query: 1949 ---LPTSEPEADAEIEPKESNGTKLEEPINEE--TPSQDEEEGVSDVESERSQEQPDKTV 2003
L + E + A +P+ G K + NEE P D+ + + +EQ +KT+
Sbjct: 2746 DDLLRSGEFDIIAYTDPELDMGDK-KSMFNEELDLPIDDKLDNQCVSVEPKKKEQENKTL 2804
Query: 2004 DISDLAT--KLLDSWKDLK-EVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRS 2060
+SD + K ++K EV K +++ E + +D V TP + S
Sbjct: 2805 VLSDKHSPQKKSTVTNEVKTEVLSPNSKVESKCETEKNDENKDNV----DTPCSQASAHS 2860
Query: 2061 RERDPDKQTQNK------EKRKRRSSLSPPSSAYERGTKRP 2095
D +K + + EKR R + P ++ + T+ P
Sbjct: 2861 DLNDGEKTSLHPCDPDLFEKRTNRETAGPSANVIQASTQLP 2901
Score = 38.5 bits (88), Expect = 0.086
Identities = 59/277 (21%), Positives = 114/277 (41%), Gaps = 27/277 (9%)
Query: 1972 EPINEETPSQDEEEGVSDVES--ERSQEQPDKTVDISDLATKLLD-----SWKDLKEVY- 2023
+P N T S EG +D S +RS + +K + ++AT ++ +LKE +
Sbjct: 1610 DPNNSWTSSAPTVEGENDTMSNAQRSTLKWEKEEALGEMATVAPVLYTNINFPNLKEEFP 1669
Query: 2024 ----RIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRS 2079
R+ + ++ ++ ++ ER RD A + D K+ Q ++ S
Sbjct: 1670 DWTTRVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQMSNDSMKRQQQQDSIDPSS 1729
Query: 2080 SLSPPSSAYERGTKRPDDRYDTPTS-KKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQ 2138
+ S ++ K+ + ++ ++++R K + + E +KL + + Q++ Q+QQ
Sbjct: 1730 RID--SELFKDPLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQQQQQQ 1787
Query: 2139 QQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAY-------VDPSNP--NAGKVLL 2189
Q+L + S S G +P P G P Q++ PS P + +
Sbjct: 1788 FGSQHLLVQSGSDTPSSGIQSPLTPQPGNGNMSPAQSFHKELFTKQPPSTPTSTSSDDVF 1847
Query: 2190 PTPSMDPVCSPAPYDHAQPLVGHSTEPLSAPPPVPVV 2226
P P P P P+ ++ ++ PP P V
Sbjct: 1848 VKPQAPP---PPPAPSRIPIQDSLSQAQTSQPPSPQV 1881
Score = 36.6 bits (83), Expect = 0.33
Identities = 31/126 (24%), Positives = 52/126 (41%), Gaps = 12/126 (9%)
Query: 185 SPPSSPPPPPPPAQATTLSSPAPVTEPVA------LPHTPITVLMAAPVPLPV----DVA 234
+PP+S PP PPP +++ TE +A + H L P LP D+
Sbjct: 3899 TPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRPQDDLL 3958
Query: 235 VRSLKE-PPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKD-EEI 292
R+L + P + VP SL + +++H + + S +S +G +
Sbjct: 3959 ARALAQGPKTVDVPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRY 4018
Query: 293 PDSSKI 298
PD S +
Sbjct: 4019 PDLSLV 4024
Score = 34.3 bits (77), Expect = 1.6
Identities = 30/126 (23%), Positives = 49/126 (38%), Gaps = 11/126 (8%)
Query: 2276 NQQSVSVQQQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQ 2335
N+Q QQQ+ SQ + G P+ G+ SP TP P+ + ++
Sbjct: 1778 NEQQQQQQQQFG---SQHLLVQSGSDTPSS-GIQSPL---TPQPGNGNMSPAQSF--HKE 1828
Query: 2336 IFTAHPQGVVVQPAAAVTTIVAPGQPQPLQPSEMVVTNNLLDLPPPSPPKPKTIVLPPNW 2395
+FT P ++ + P P PS + + ++L PP P+ V P
Sbjct: 1829 LFTKQPPSTPTSTSSDDVFVKPQAPPPPPAPSRIPIQDSLSQAQTSQPPSPQ--VFSPGS 1886
Query: 2396 KTARDP 2401
+R P
Sbjct: 1887 SNSRPP 1892
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 88.2 bits (217), Expect = 9e-17
Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 1/128 (0%)
Query: 1562 WGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKG 1621
WGL A + + ++ V+EY G+ + R K Y Y + +D IIDAT+ G
Sbjct: 1796 WGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCG 1855
Query: 1622 NCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCG 1681
N +RF+NHSC PNC + TV Q ++ ++ + + E+T+DY+F + C CG
Sbjct: 1856 NFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKI-PCLCG 1914
Query: 1682 SANCRGYL 1689
S NCRG L
Sbjct: 1915 SENCRGTL 1922
Score = 48.1 bits (113), Expect = 1e-04
Identities = 39/159 (24%), Positives = 59/159 (37%), Gaps = 18/159 (11%)
Query: 101 PNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHL-LHVTSRPLLAT 159
P PP P D + L + +P +++ G+ + + + P
Sbjct: 592 PRPPPEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPI 651
Query: 160 TTA------VASPPTHAAPLPAVIAESTTVDSPPS-----SPPPPPPPAQATTLSSPAPV 208
T+A V +P A P+V+A + + PP PPPPPPP + P P
Sbjct: 652 TSADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPP 711
Query: 209 TEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVP 247
P P P + P+P P V PP I+ P
Sbjct: 712 PPPPPPPAHPAVTVPPPPLPAPPGV------PPPPILPP 744
Score = 41.2 bits (95), Expect = 0.013
Identities = 124/585 (21%), Positives = 198/585 (33%), Gaps = 100/585 (17%)
Query: 1885 SENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNI 1944
SE D ++D EL +D K ++ + P +L + E
Sbjct: 994 SERERDRDMADTPCELAKRDPKG-------------VGVRRRPARPLELDSGGEEDEKES 1040
Query: 1945 EASKLPTSEPEADAEIEPKESN-----------------GTKLEEPINEETPSQDEEEGV 1987
+ + ++E E +AE E +E + T L E ++ DEEE V
Sbjct: 1041 LSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETV 1100
Query: 1988 SDVESE---RSQEQPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKENTTTERGRDA 2044
S V S+ S + ++ + + S +D +EV ++ + E+E E +
Sbjct: 1101 SIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMAS 1160
Query: 2045 VGFRD----------QTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYERGTKR 2094
G D AP + E + D +T+ +R S L P G +
Sbjct: 1161 AGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPV--GVEE 1218
Query: 2095 PDDRYDTP-----TSKKKVRIKDRNKLSTEERRKLFEQEVAQR---EAQKQQQQMQNLGM 2146
P D + P + + + + E R E A E + + M L +
Sbjct: 1219 PADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPL 1278
Query: 2147 TSPL-----PYDSLGYNAPHHPFAGYP--PGYPMQAYVDPSNPNAGKVLLPTPSMDPVCS 2199
PL P P A +P P P+ P P L + S + V
Sbjct: 1279 QPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETV-- 1336
Query: 2200 PAPYDHAQPLVGHSTEPLSAPPPVPVVP-HVAAPVEVSSSQYVAQSDG-------VVHQD 2251
PA PL G S+ + P VP P AP SS + ++ G +
Sbjct: 1337 PATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPGRDFSFTPTFSEP 1396
Query: 2252 SSVAVLPV-PAP--------GPVQGQNYSVWDSNQQSVSVQQQYSPAQSQATIYYQGQT- 2301
S +LPV P P GP+ + ++ P A + Q +
Sbjct: 1397 SGPLLLPVCPLPTGRRDERSGPLASP--VLLETGLPLPLPLPLPLPLALPAVLRAQARAP 1454
Query: 2302 CPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPAAAVT----TIVA 2357
P + +P + PP+ + +P + G +V+P A ++
Sbjct: 1455 TPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSL-----DGPLVRPPAGAALGRELLLL 1509
Query: 2358 PGQPQ-PLQPSEMVVTNNLLDL--------PPPSPPKPKTIVLPP 2393
PGQPQ P+ PS LD PPP PP+P PP
Sbjct: 1510 PGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPP 1554
Score = 38.1 bits (87), Expect = 0.11
Identities = 66/284 (23%), Positives = 96/284 (33%), Gaps = 35/284 (12%)
Query: 1961 EPKESNGTKLEE--PINEETPSQDEEEGVSDVESERSQE-----QPDKTVDISDLATKLL 2013
EP +S GT E P E P + + + E+ + +PD ++ + +
Sbjct: 475 EPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSPIS 534
Query: 2014 DSWKDLKEVYRIPKKSQTEKENTTTERGR-DAVGFRDQTPAPKTPNRSRERDPDKQTQNK 2072
S L + SQ T R + G D +P P + D D++
Sbjct: 535 SSSSQLSPLAPFGTNSQPGFRGPTPPSSRPSSTGLEDISPTPLP-----DSDEDEELDLG 589
Query: 2073 EKRKRRSSLSPP------SSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFE 2126
+ PP S E DR TPTS+K D + S+ E ++ +
Sbjct: 590 LGPRPPPEPGPPDPAGLLSQTAEVALDLVGDR--TPTSEKM----DEGQQSSGEDMEISD 643
Query: 2127 QEVAQR---EAQKQQQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPN 2183
E+ A + + G + L P P PPG+P P P
Sbjct: 644 DEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLPP----PPGFPPLPPPPPPPPP 699
Query: 2184 AGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTEPLSAPPPVPVVP 2227
+P P P P P A P V PL APP VP P
Sbjct: 700 QPGFPMPPPLPPPPPPPPP---AHPAVTVPPPPLPAPPGVPPPP 740
Score = 37.0 bits (84), Expect = 0.25
Identities = 42/184 (22%), Positives = 64/184 (34%), Gaps = 35/184 (19%)
Query: 972 ERRGRPEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGV------TYALKCDSSG 1025
++R RP S+DE E D ++ + C+L D GV L+ DS G
Sbjct: 978 QKRLRPSTSVDEEDEESE--RERDRDMADTPCEL--AKRDPKGVGVRRRPARPLELDSGG 1033
Query: 1026 HAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQ------------------ 1067
E S E S E +E + E+ D DD S R+ +
Sbjct: 1034 EEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGD 1093
Query: 1068 -------SVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESI 1120
S+V +T E + SS S E+E + EE+ E +
Sbjct: 1094 SDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMV 1153
Query: 1121 ASKA 1124
A ++
Sbjct: 1154 AEES 1157
Score = 37.0 bits (84), Expect = 0.25
Identities = 33/129 (25%), Positives = 47/129 (36%), Gaps = 22/129 (17%)
Query: 92 LGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHV 151
+G E+ +D+ PP P + E LS + ++R L +H L V
Sbjct: 1214 VGVEEPADSREPP-------EEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEV 1266
Query: 152 TSRPLLATTTAVASPPTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEP 211
P + + P P P P PP PPP + T S P+ EP
Sbjct: 1267 EPEPPMMLPLPLQPP----LPPPR-----------PPRPPSPPPEPETTDASHPSVPPEP 1311
Query: 212 VALPHTPIT 220
+A H P T
Sbjct: 1312 LAEDHPPHT 1320
Score = 33.1 bits (74), Expect = 3.6
Identities = 34/129 (26%), Positives = 48/129 (37%), Gaps = 24/129 (18%)
Query: 95 EKQSDTPNPPAVPLQVDSTPK-MKMEIG-------DTLSTAEESSPPKSRVELGKIHFKK 146
+ ++ TP PP +P + S P MK + G LS P + LG+
Sbjct: 1450 QARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRPPAGAALGR----- 1504
Query: 147 HLLHVTSRPLLATTTAVASPPTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPA 206
LL + +P P TH + + + +PP PP PPP P
Sbjct: 1505 ELLLLPGQP-----QTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPP------PP 1553
Query: 207 PVTEPVALP 215
P EP LP
Sbjct: 1554 PPVEPTKLP 1562
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 87.4 bits (215), Expect = 2e-16
Identities = 182/851 (21%), Positives = 290/851 (34%), Gaps = 102/851 (11%)
Query: 272 NEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESD------- 324
N+++D K DS D + DSS S S + S S S S+SD
Sbjct: 537 NDKSDSGKGKSDS---SDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDS 593
Query: 325 --EDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSK 382
DS +S S S D S+ D K S+ KSE S SK+D D S S
Sbjct: 594 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSS--KSESDSSDSDSKSDSSDSNSSDSS 651
Query: 383 LERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHRSSPYRE 442
D+ + S + S S S ++ S S S+ S+ DS S+
Sbjct: 652 DNSDS----------SDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN---- 697
Query: 443 RTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYL 502
S +D+ SDS + + S + S SS+ D SS S D ++
Sbjct: 698 ----SSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSS 753
Query: 503 EMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKP 562
+ S+ + S + + S N+ SS S + S +S +
Sbjct: 754 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSS 813
Query: 563 IPKSDKFKNSFCCTELNEEIKQSHS--FSLQTPCSKGSELRMINKNPEREKAGSPAPSNR 620
NS + ++ S+S S + S GS+ N++ + S S+
Sbjct: 814 DSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDS 873
Query: 621 LNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAE 680
N S + D S DS DS DS S ++ S + +
Sbjct: 874 SNSSDSSDSSDSNESSNSS----DSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNS 929
Query: 681 SDLATFCTSKTDAVLMTSDDSVTGSELSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHK 740
SD + S + S DS S+ S +S+ N S + + D+
Sbjct: 930 SDNSNSSDSSNSSDSSDSSDSSNSSDSS--------NSSDSSNSSDSSDSNSSDSSDSSN 981
Query: 741 KSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCTLNDS 800
S+S S D S + D+ S + SD + + S
Sbjct: 982 SSDSSDSSDSSDSSDSSDSSNS-------------SDSSDSSDSSDSSNSSDSSNSSDSS 1028
Query: 801 NPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTS 860
N S + +++ + S SS+S + + DS + +D S + S S+
Sbjct: 1029 NSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSD--SSDSSDSSESSD 1086
Query: 861 SASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEF 920
S+ ++ D SS + S S DS N+S D+ S S
Sbjct: 1087 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDS-------SNSSDSSDSSDSSDSSDS- 1138
Query: 921 LKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGNSILPERRGRPEIS 980
++ + SD DS S ++ ++ S ++ + NS
Sbjct: 1139 -SNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSS-----DSSDSSNS------------ 1180
Query: 981 LDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSG 1040
+ + S DS S D + + + SD + DSS + S D S
Sbjct: 1181 -SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSD 1239
Query: 1041 SSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDH 1100
SS+SS+ + S+ +DS DSS +ST + S S+S + SD
Sbjct: 1240 SSDSSDSSNSSDSSDSSDSS--------------DSTSDSNDESDSQSKSGNGNNNGSDS 1285
Query: 1101 WEDERLESRRH 1111
D H
Sbjct: 1286 DSDSEGSDSNH 1296
Score = 71.6 bits (174), Expect = 9e-12
Identities = 170/820 (20%), Positives = 282/820 (34%), Gaps = 58/820 (7%)
Query: 604 NKNPEREKAGSPAPSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQL 663
N N + +K+ S + +DS + + S+ DS DS DS S +
Sbjct: 532 NGNDDNDKSDSGKGKSDSSDSDSSDSSNSSD--SSDSSDSDSSDSNSSSDSDSSDSDSSD 589
Query: 664 RSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSELSPLVKACMLSSNGFQN 723
S + N S ++S ++ + +D+ SD S + S+ S S + +
Sbjct: 590 SSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSD 649
Query: 724 ISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRV 783
S D D+ S+S S D S D S +
Sbjct: 650 SS--DNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSS-----DSSDSSDSSNSSESS 702
Query: 784 SCCKTKDSDIYCTLNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTD 843
+ DSD + + SN + +S++ N S SSNS + DS + +D
Sbjct: 703 DSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDS--SDSSNSSDSSDSSDSSNSSDSSDSSD 760
Query: 844 HSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKCGEN 903
S + + S S+ S+ ++ D SS + S S DS +
Sbjct: 761 SSNSS--DSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDS-------SD 811
Query: 904 TSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQ 963
+S D+ + S + + SD DS G S + R++ + ++
Sbjct: 812 SSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSS 871
Query: 964 EEGNSILPERRGRPEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDS 1023
+ NS S D ++SD S+ SS + SD + DS
Sbjct: 872 DSSNS---------SDSSDSSDSNESSNSSDSSDSSNSS-----DSDSSDSSNSSDSSDS 917
Query: 1024 SGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPMEET 1083
S + S+ D S SS+SSN S+ +DS +SS N S NS+ +
Sbjct: 918 SNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDS-----SNSSDSSDSN 972
Query: 1084 SPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEI 1143
S SS SS S SD + + S +S + +D + +
Sbjct: 973 SSDSSDSSNS----SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS 1028
Query: 1144 SFTQSSRKQIDNRLPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQEELP 1203
+ + SS D+ S SD DS++ +D SD +S ++ + S E
Sbjct: 1029 NSSDSSDSS-DSSDSSDSSDSSDSSDSSNSSD-SSDSSDSSDSSDSSDSSDSSDSSE--- 1083
Query: 1204 IYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGWDFS 1263
SSD D N S + + S + S SS D SS+ + D S
Sbjct: 1084 --SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS--DSS 1139
Query: 1264 QEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRT 1323
S+ + S + +++ + N S + D +
Sbjct: 1140 NSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1199
Query: 1324 QGQVPDSLTDDREEEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAV 1383
+D + ++ D D S SD SD S + S + S++ D+
Sbjct: 1200 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD----SNESSDSSDSSDSSDSSNSSDSSDS 1255
Query: 1384 NEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQD 1423
++ D + + ND D SDS+SD E D
Sbjct: 1256 SDSSDSTS--DSNDESDSQSKSGNGNNNGSDSDSDSEGSD 1293
Score = 67.4 bits (163), Expect = 2e-10
Identities = 150/725 (20%), Positives = 241/725 (33%), Gaps = 37/725 (5%)
Query: 248 ESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGS 307
+S ++ D+ +S + + + S K DS + D+S S S + S
Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNS 665
Query: 308 KKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPS 367
S S+ S S DS +S S S D S+ D S + S D +
Sbjct: 666 SDSSDSSDS--SDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSS-DSSDSSNSN 722
Query: 368 RSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHY 427
S +D + S SS + + S S S S ++ S S+ S+
Sbjct: 723 SSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS 782
Query: 428 YDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSS 487
DS + SS + + S + + +SSDS + S + S +SS ++S
Sbjct: 783 SDS----NDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNS 838
Query: 488 YSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFRRGSSYSK 547
SD ++ S + R S+ + S N + S NE SS S
Sbjct: 839 SDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSS 898
Query: 548 H----DSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMI 603
+ DSS S S S SD ++S N + S S + S S
Sbjct: 899 NSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSN 958
Query: 604 NKNPEREKAGSPAPSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQL 663
+ + S + S+ +DS + + DS +S DS +
Sbjct: 959 SSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNS 1018
Query: 664 RSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSELSPLVKACMLSSNGFQN 723
+ N S ++S ++ + +D+ S DS S+ S SS+ +
Sbjct: 1019 SDSSNSSDSSNSSDSSDSSDSSDSSDSSDS--SDSSDSSNSSDSSD-------SSDSSDS 1069
Query: 724 ISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRV 783
D D+ S+S S D S D S + + D+
Sbjct: 1070 SDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSS-----DSSDS--SDSSDSSN 1122
Query: 784 SCCKTKDSDIYCTLNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTD 843
S + SD + + SN S + +E+ + S SS+S + DS N +D
Sbjct: 1123 SSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD 1182
Query: 844 HSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKCGEN 903
S + S S+ S+ + D SS + S S DS N
Sbjct: 1183 SS-----DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS-----SDSN 1232
Query: 904 TSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQ 963
S S SS + + SD D + N NNG E
Sbjct: 1233 ESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGS 1292
Query: 964 EEGNS 968
+ +S
Sbjct: 1293 DSNHS 1297
Score = 63.2 bits (152), Expect = 3e-09
Identities = 133/635 (20%), Positives = 216/635 (34%), Gaps = 38/635 (5%)
Query: 790 DSDIYCTLN--DSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKF 847
DSD N DSN + N +N + K S+S S DS N +D S
Sbjct: 514 DSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDS-------SDSDSSDSSNSSDSSDS 566
Query: 848 ACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKCGENTSPV 907
+ + S S+ S S + SS ++S S DS ++S
Sbjct: 567 SDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDS-------SDSSDS 619
Query: 908 LDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGN 967
D+ S KS + ++ + S +S + +N ++ + +
Sbjct: 620 SDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSS 679
Query: 968 SILPERRGRPEISLDERGEGGHVHTSD--DSEVVFSSCDLNLTMEDSDGVTYALKCDSSG 1025
S S D +SD DS+ SS N DSD + DSS
Sbjct: 680 SSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSN 739
Query: 1026 HAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPMEETSP 1085
+ S+ + S SS+SS+ + S+ +DS DSS + S +++ ++S
Sbjct: 740 SSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSN 799
Query: 1086 CSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEISF 1145
S S+ S S D + S +S + +D G++ +
Sbjct: 800 SSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSD----- 854
Query: 1146 TQSSRKQIDNRLPELSHPQSDGVDSTSHTDV--KSDPLGHPNSEETVKAKIPSRQQEELP 1203
S+R N S SD DS++ +D SD NS ++ + S
Sbjct: 855 -SSNRSDSSN-----SSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDS 908
Query: 1204 IYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGWDFS 1263
SSD D N S + + +S + S SS D +SS+ + D S
Sbjct: 909 SNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSS---DSSDSSNSSDSSNSS--DSS 963
Query: 1264 QEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRT 1323
S+ DSS + +++ + N S + D +
Sbjct: 964 NSSDSSDSNSSDSS-DSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSS 1022
Query: 1324 QGQVPDSLTDDREEEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAV 1383
+ +D + ++ D D S SD SD S D SS+S D+
Sbjct: 1023 NSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDS-SDSSDS 1081
Query: 1384 NEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESD 1418
+E D S + +D D +S SD
Sbjct: 1082 SESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1116
Score = 56.6 bits (135), Expect = 3e-07
Identities = 107/452 (23%), Positives = 158/452 (34%), Gaps = 48/452 (10%)
Query: 249 SLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSK 308
S +D+ SNS + + ++ ++ S+ ++S+ DSS S S + S
Sbjct: 898 SNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSS 957
Query: 309 KKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSR 368
S S SD +S +S S S D S+ D SS S D S
Sbjct: 958 NSSDSSNS---SDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1014
Query: 369 SKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYY 428
S D S S D SS + S S S S ++ S S+ S
Sbjct: 1015 SSNSSDSSNSSDSSNSSD----SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1070
Query: 429 DSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSY 488
DS SS + + S + + +SSDS + + SS SS D SS
Sbjct: 1071 DSS----DSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSS----DSSDSSDSSDSSDSSN 1122
Query: 489 SKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFRRGSSYSKH 548
S D + + S E S + + S ++ SS S
Sbjct: 1123 SSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSS- 1181
Query: 549 DSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPE 608
DSS S S S SD +S + + S S + S S+ N++ +
Sbjct: 1182 DSSDSSDSSDSSDSSDSSDSSDSSD-----SSDSSDSSDSSDSSDSSDSSDSSDSNESSD 1236
Query: 609 REKAGSPAPSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCP 668
+ + S+ +DS S T DS+D E DS SK N
Sbjct: 1237 SSDSSDSSDSSNSSDSSDSS--------DSSDSTSDSND---ESDSQSKSGNG------- 1278
Query: 669 IELNINGSPGAESDLATFCTSKTDAVLMTSDD 700
N NGS ++SD + +D+ TSDD
Sbjct: 1279 ---NNNGS-DSDSD-----SEGSDSNHSTSDD 1301
Score = 52.8 bits (125), Expect = 4e-06
Identities = 98/488 (20%), Positives = 171/488 (35%), Gaps = 24/488 (4%)
Query: 939 SGKGFASRENRRNNGLSGKCL---QEAQEEGNSILPERRGRPEISLDERGEGGHVHTSDD 995
+G A+ E+ N+ G E+++ GN + +G + D+ + SD
Sbjct: 472 NGNDDANSESDNNSSSRGDASYNSDESKDNGNG--SDSKGAED---DDSDSTSDTNNSDS 526
Query: 996 SEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTD 1055
+ + D N + G + + DSS + S+ D S +S+ +SDS D+D
Sbjct: 527 NGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSD 586
Query: 1056 SDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEE 1115
S DSS + S +S S SS SS S SD + E S +
Sbjct: 587 SSDSSDSDSSDSS-----NSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSD 641
Query: 1116 KFESIASKACPQTDKFFLHKGTEKNPEISFTQSSRKQIDNRLPELSHPQSDGVDS--TSH 1173
+S +S + +D + + S + S D+ S SD DS +S+
Sbjct: 642 SSDSNSSDSSDNSDS----SDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN 697
Query: 1174 TDVKSDPLGHPNSEETVKA-KIPSRQQEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGK 1232
+ SD +S+ + + S + SSD D N S + + S
Sbjct: 698 SSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSD 757
Query: 1233 TELSFSSSCEIPHVDGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQ 1292
+ S +SS D SS+ + + S ++ S ++
Sbjct: 758 SSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSD 817
Query: 1293 YGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDS--LTDDREEEENWDQQDGSHFS 1350
+ N S + D + G DS +D ++ D D S+ S
Sbjct: 818 SDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSS 877
Query: 1351 DQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLEKNDIKDRGPLKKRRQE 1410
D SD + S + + S++S D+ + D S + +D +
Sbjct: 878 DSSDS--SDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNS 935
Query: 1411 IESDSESD 1418
+S + SD
Sbjct: 936 SDSSNSSD 943
Score = 37.7 bits (86), Expect = 0.15
Identities = 47/273 (17%), Positives = 95/273 (34%), Gaps = 13/273 (4%)
Query: 1838 SEGDGYSSENTSRAHTPLNTPDPSTKLSTEADT-DTPKKLMFRRLKIISENSMDSA---- 1892
S+ D S N+S + ++ + S+++D+ D+ S NS DS+
Sbjct: 550 SDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSD 609
Query: 1893 ISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTS 1952
SD++ + D K D + E+ + + + S DS N ++S S
Sbjct: 610 SSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSD-------SNSSDSSDNSDSSDSSNS 662
Query: 1953 EPEADAEIEPKESNGTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLA-TK 2011
+D+ S+ + + N S + S S+ S + D SD + +
Sbjct: 663 SNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSN 722
Query: 2012 LLDSWKDLKEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQN 2071
DS S +++ + D+ D + + + + S D + +
Sbjct: 723 SSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS 782
Query: 2072 KEKRKRRSSLSPPSSAYERGTKRPDDRYDTPTS 2104
+ +S S+ + D D+ S
Sbjct: 783 SDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDS 815
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 85.9 bits (211), Expect = 5e-16
Identities = 42/128 (32%), Positives = 69/128 (53%), Gaps = 1/128 (0%)
Query: 1562 WGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKG 1621
WGL A + + ++ V+EY G+ + R K Y + Y + +D IIDAT+ G
Sbjct: 1580 WGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCG 1639
Query: 1622 NCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCG 1681
N +RF+NH C PNC + T+ Q ++ ++ + + E+T+DY+F + C CG
Sbjct: 1640 NLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFPLEDNKI-PCLCG 1698
Query: 1682 SANCRGYL 1689
+ +CRG L
Sbjct: 1699 TESCRGSL 1706
Score = 42.7 bits (99), Expect = 0.005
Identities = 30/102 (29%), Positives = 47/102 (46%), Gaps = 1/102 (0%)
Query: 249 SLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSK 308
S E+ +++D + E+ + E D + K+ + G+DEE SSK SL G
Sbjct: 969 SQESSSEKDEEDDE-EDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGEN 1027
Query: 309 KKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERD 350
+S SE S S S +SSS S + S+ E+E +
Sbjct: 1028 DSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEE 1069
Score = 38.5 bits (88), Expect = 0.086
Identities = 41/165 (24%), Positives = 64/165 (38%), Gaps = 31/165 (18%)
Query: 158 ATTTAVASPPTHAAPLPAVIAESTTVD-SPPSS---PPPPPPPAQATTLSSPAPVTEPVA 213
A TA PP++ + LP + T D PP+S PP PP P P+P E V
Sbjct: 398 AENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVR 457
Query: 214 LPHTPIT-VLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQDTISNSLEEHVTQILN 272
P + +P P + +V + +SL+ + +L
Sbjct: 458 TSPRPASPARSGSPAPETTNESVPFAQH--------------------SSLDSRIEMLLK 497
Query: 273 EQADISSKKEDSHIGKD-EEIPDSSKISLSCKKTGSKKKSSQSEG 316
EQ + + S + D EE ++S + L + TGS+ S G
Sbjct: 498 EQ-----RSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHG 537
Score = 37.4 bits (85), Expect = 0.19
Identities = 52/270 (19%), Positives = 89/270 (32%), Gaps = 51/270 (18%)
Query: 1964 ESNGTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKEVY 2023
+S G + + + E +D+EE D + E + + K ++SD + DS
Sbjct: 962 DSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSS------ 1015
Query: 2024 RIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSP 2083
+ + ++ EN +T + + + + + S + + E+ + R + P
Sbjct: 1016 KCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALP 1075
Query: 2084 PSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQN 2143
+S R P TP E V +R A
Sbjct: 1076 SASPPPREVPVP-----TPAP--------------------VEVPVPERVAGSP------ 1104
Query: 2144 LGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCS---- 2199
+PLP P P PP P++ P+ P A P P D S
Sbjct: 1105 ---VTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPA-----PAPRPDERPSSPIP 1156
Query: 2200 --PAPYDHAQPLVGHSTEPLSAPPPVPVVP 2227
P P + + + E + AP P P P
Sbjct: 1157 LLPPPKKRRKTVSFSAIEVVPAPEPPPATP 1186
Score = 35.4 bits (80), Expect = 0.73
Identities = 26/73 (35%), Positives = 31/73 (42%), Gaps = 15/73 (20%)
Query: 151 VTSRPLLATTTAVASPPTHAAPLPAVIAESTTVDSPPSSP-PPPPPPAQATTLSSPAPVT 209
V P+ ASP A P T +SPPS+P PP PPA PAP
Sbjct: 1100 VAGSPVTPLPEQEASPARPAGP---------TEESPPSAPLRPPEPPA-----GPPAPAP 1145
Query: 210 EPVALPHTPITVL 222
P P +PI +L
Sbjct: 1146 RPDERPSSPIPLL 1158
Score = 34.7 bits (78), Expect = 1.2
Identities = 56/238 (23%), Positives = 87/238 (36%), Gaps = 50/238 (21%)
Query: 6 PQPPPKMGDFYDPEHPTPEEEE--NEAKIENVQKTGF-IKGPMFKGVASSRFLPKGTKTK 62
P PP+ G P+PE EE + + ++G + V ++ ++ +
Sbjct: 434 PPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIE 493
Query: 63 VNLEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPN---------PPAVPLQVDST 113
+ L+EQ R K SF S T++ +N + + S+ P+ PPA D
Sbjct: 494 MLLKEQ-RSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVA 552
Query: 114 PKMKMEIGDTLSTAE-----ESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPT 168
P E G T + + ++SP S ++ ++ SPP
Sbjct: 553 PTGSGEPGATRESPKANGQNQASPCSSGDDME----------------ISDDDRGGSPPP 596
Query: 169 HAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAP 226
AP P PP PPPPPPP +L P PH P +L P
Sbjct: 597 --APTPPQ-------QPPPPPPPPPPPPPYLASLPLGYP-------PHQPAYLLPPRP 638
Score = 33.9 bits (76), Expect = 2.1
Identities = 55/257 (21%), Positives = 95/257 (36%), Gaps = 34/257 (13%)
Query: 256 QDTISN-SLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQS 314
++T+ N L + I++ Q DI ++ + E+ + + TG K S +
Sbjct: 149 KETVKNLHLTSVMGNIIHAQLDIKGQQRMKYY----ELIVNGSYTPQTVPTGGKALSEKF 204
Query: 315 EGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSRSKTDRD 374
+G +E+ E R+SS ++ P + +G P
Sbjct: 205 QGSGAATETAESRRRSSSDTAAY-------------------PAGTTAVGTPGNGTPCSQ 245
Query: 375 DKYFSYSKLERDTRYVSSRCRSER----ERRRSRSHSRSERGSRTNLSYS----RSERSH 426
D FS S+ + + + +S + R S +S+ S + S S RSE S+
Sbjct: 246 DTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSY 305
Query: 427 YYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYR--DLR 484
RR+ +S + T SS S + S +SS SS +R D
Sbjct: 306 QDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDAN 365
Query: 485 TSSYSKSDRDCKTETSY 501
+Y +S + TSY
Sbjct: 366 YPAYYESWNRYQRHTSY 382
Score = 33.5 bits (75), Expect = 2.8
Identities = 54/263 (20%), Positives = 84/263 (31%), Gaps = 21/263 (7%)
Query: 2019 LKEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRR 2078
L+ R+P KE + + ++ P P TP E DP+++ + E R
Sbjct: 884 LRGALRLPSFKVKRKEPSEISEASE-----EKRPRPSTPAEEDEDDPEQEKEAGE--PGR 936
Query: 2079 SSLSPPSSAYERGTKRPDDR-----------YDTPTSKKKVRIKDRNKLSTEERRKLFEQ 2127
PP ERG + R +S +K D E+R + +
Sbjct: 937 PGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDT 996
Query: 2128 EVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKV 2187
+ E + + + L DS G N + S+ ++
Sbjct: 997 TKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSS 1056
Query: 2188 LLPTPSMDPVCS--PAPYDHAQPLVGHSTEPLSAPPPVPVVPHVA-APVEVSSSQYVAQS 2244
+ S D PA A P P AP VPV VA +PV Q + +
Sbjct: 1057 SSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPA 1116
Query: 2245 DGVVHQDSSVAVLPVPAPGPVQG 2267
+ S P+ P P G
Sbjct: 1117 RPAGPTEESPPSAPLRPPEPPAG 1139
Score = 32.7 bits (73), Expect = 4.7
Identities = 42/227 (18%), Positives = 77/227 (33%), Gaps = 8/227 (3%)
Query: 6 PQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNL 65
P+ + G+ P P+ +E K + + F +G +S+ + +
Sbjct: 925 PEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDS--EGEEASQESSSEKDEEDDE 982
Query: 66 EEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLS 125
E++ + + TKK + + G +++SD+ + ++ D + + S
Sbjct: 983 EDEEDEDREEAVDTTKKETE----VSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSS 1038
Query: 126 TAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPAVIAESTTVDS 185
++ SS S + ASPP P+P V
Sbjct: 1039 SSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPE 1098
Query: 186 PPSSPPPPPPPAQATTLSSPAPVTE--PVALPHTPITVLMAAPVPLP 230
+ P P P Q + + PA TE P + P P P P P
Sbjct: 1099 RVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAP 1145
Score = 32.0 bits (71), Expect = 8.1
Identities = 68/294 (23%), Positives = 106/294 (36%), Gaps = 38/294 (12%)
Query: 331 SSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYV 390
SSS S L S+S SS+ +S D P+ Y S+++ +R T Y
Sbjct: 336 SSSASSSSLSSSSSSSSS----SSSSQFRSSDANYPAY--------YESWNRYQRHTSYP 383
Query: 391 SSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHRSSPYRERTRYSRPY 450
R E + + +ER + SY E S D D R P E P
Sbjct: 384 PRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYR----PPASEAPPPEPPE 439
Query: 451 TDNRARESSDS-EEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEM---ER 506
S E E +T R S S T++ S + S +EM E+
Sbjct: 440 PGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQ 499
Query: 507 RGKYSSKLERESKRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKS 566
R K+S L +++ EN ++ LG R S S S + P P +
Sbjct: 500 RSKFSF-LASDTEEEEENSSM--------VLGARDTGS---EVPSGSGHGPCTPPPAPAN 547
Query: 567 --DKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPAPS 618
D E +++ + +PCS G ++ + + ++ GSP P+
Sbjct: 548 FEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEI----SDDDRGGSPPPA 597
Score = 32.0 bits (71), Expect = 8.1
Identities = 41/161 (25%), Positives = 64/161 (39%), Gaps = 20/161 (12%)
Query: 126 TAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAV----ASPPTHAAPLPAVIAEST 181
T EE + P + V+L + L +R L AV A+ + A P +
Sbjct: 1240 TEEEEAEPGTEVDLAVL---ADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHI 1296
Query: 182 TVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEP 241
++ + P PPA A L P PV P AL +P ++ AP +V V +EP
Sbjct: 1297 LLEHNYALAVKPTPPAPA--LRPPEPVPAPAALFSSPADEVLEAP-----EVVVAEAEEP 1349
Query: 242 PIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKE 282
P+ L+ ++ EE + E +D SS +
Sbjct: 1350 K----PQQLQQQREEG--EEEGEEEGEEEEEESSDSSSSSD 1384
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 85.5 bits (210), Expect = 6e-16
Identities = 49/149 (32%), Positives = 74/149 (49%), Gaps = 2/149 (1%)
Query: 1542 RRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKN 1601
R ++ V V + G GL +++ + V+EY G V+ R K Y K
Sbjct: 2567 RHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYD-GKG 2625
Query: 1602 IHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSE 1661
I Y + + +++DAT GN +RF+NHSCEPNC ++ V GQ + F + + G E
Sbjct: 2626 IGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEE 2685
Query: 1662 LTFDYQFQ-RYGKEAQKCFCGSANCRGYL 1689
LT+DY+F C CG+ CR +L
Sbjct: 2686 LTYDYKFPIEDASNKLPCNCGAKRCRRFL 2714
Score = 45.8 bits (107), Expect = 5e-04
Identities = 88/372 (23%), Positives = 134/372 (36%), Gaps = 79/372 (21%)
Query: 2048 RDQTPAPKTP---NRSRERDPDKQTQNKEKRKRRSS---LSPPSSAYERGTKRPDDRYDT 2101
++++P P P +R R R P +Q E+ R+ SPP+ T P + D+
Sbjct: 453 QEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPE--DS 510
Query: 2102 PTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAPH 2161
PT + ++ + R+ V+ R ++ + + + P P
Sbjct: 511 PT------VAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLR 564
Query: 2162 HPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHS------TE 2215
P PP P + PS P A PTP PV P P L + T
Sbjct: 565 PPITTSPP-VPQEPAPVPSPPRA-----PTPPSTPV--PLPEKRRSILREPTFRWTSLTR 616
Query: 2216 PLSAPPPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDS 2275
L PPP P P P P+P P + S
Sbjct: 617 ELPPPPPAPPPP------------------------------PAPSPPPAPATS-----S 641
Query: 2276 NQQSVSVQQQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQ 2335
+ + Q++P+++ IY T P + +P + PP S A+P + + G+
Sbjct: 642 RRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPE-PPPADDSPAEPEPRAV-GRT 699
Query: 2336 IFTAHPQ--GVVVQPA-AAVTTIVAPG-------QPQPLQPSEMVVTNNLLD-LPPPSP- 2383
+ P+ VV P A V+ AP Q Q LQP + + T L LPPP P
Sbjct: 700 NHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQ 759
Query: 2384 --PKPKTIVLPP 2393
P P +PP
Sbjct: 760 LQPPPSPQQMPP 771
Score = 40.4 bits (93), Expect = 0.023
Identities = 19/43 (44%), Positives = 21/43 (48%)
Query: 166 PPTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPV 208
PP +P P + SPP P PPPPPAQ SP PV
Sbjct: 418 PPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPPV 460
Score = 38.5 bits (88), Expect = 0.086
Identities = 49/196 (25%), Positives = 70/196 (35%), Gaps = 37/196 (18%)
Query: 56 PKGTKTKVNLEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQ------ 109
PK T N+ + VS S KT RF+ D P PP V +
Sbjct: 515 PKSTTFLKNIRQFIMPVVSARSSRVIKT-PRRFM-------DEDPPKPPKVEVSPVLRPP 566
Query: 110 VDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTH 169
+ ++P + E S +PP + V L + ++ +L + + T + PP
Sbjct: 567 ITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEK--RRSILREPTFRWTSLTRELPPPPP- 623
Query: 170 AAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALP---HTPITVLMAAP 226
+PP P P PPPA AT+ P + P P H I + P
Sbjct: 624 ---------------APPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTP 668
Query: 227 VPLPVDVAVRSLKEPP 242
PL A EPP
Sbjct: 669 PPLGAPEAPE--PEPP 682
Score = 37.0 bits (84), Expect = 0.25
Identities = 22/75 (29%), Positives = 32/75 (42%), Gaps = 6/75 (8%)
Query: 173 LPAVIAESTTVDSPPSSPPPP--PPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLP 230
+PA E + PP +PP P PPP + S P P+ P P +P + P P P
Sbjct: 391 MPAAEKEEAKLPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPL----PSPPP 446
Query: 231 VDVAVRSLKEPPIII 245
+ PP ++
Sbjct: 447 PPAQEEQEESPPPVV 461
Score = 35.0 bits (79), Expect = 0.95
Identities = 17/42 (40%), Positives = 18/42 (42%)
Query: 166 PPTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAP 207
P T AP P + PP PPPPPP L SP P
Sbjct: 405 PLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPP 446
Score = 32.7 bits (73), Expect = 4.7
Identities = 16/43 (37%), Positives = 21/43 (48%), Gaps = 2/43 (4%)
Query: 165 SPPTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAP 207
+PP + P P + +T PP PPPPPP + S P P
Sbjct: 407 TPPAPSPPPP--LPPPSTSPPPPLCPPPPPPVSPPPLPSPPPP 447
Score = 32.0 bits (71), Expect = 8.1
Identities = 20/78 (25%), Positives = 31/78 (39%), Gaps = 1/78 (1%)
Query: 154 RPLLATTTAVASPPTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPA-PVTEPV 212
+P L T + +P + P ++ V +PPPPPPP S PA P + +
Sbjct: 2217 QPPLPPTISPTAPTSWTLPPGPLLGVLPVVGVVRPAPPPPPPPLTLVLSSGPASPPRQAI 2276
Query: 213 ALPHTPITVLMAAPVPLP 230
+ + P P P
Sbjct: 2277 RVKRVSTFSGRSPPAPPP 2294
>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 72.0 bits (175), Expect = 7e-12
Identities = 87/342 (25%), Positives = 145/342 (42%), Gaps = 44/342 (12%)
Query: 236 RSLKEPPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDS 295
R KE ++ + E + + ++ + E + + N + + +++ D + +++ +
Sbjct: 428 RKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPN 487
Query: 296 SKISLSCKKTGSKKKSSQSE---GIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFK 352
S+ K K+K Q G S +S +S+S +S+S R
Sbjct: 488 ETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSS 547
Query: 353 KSSAPLKSEDLGKPSRSKT-----DRDDKYFSYSKLERDTRYVSSRCRS-------ERER 400
+SS+P + + + SRS T R Y K+E + V R R ERER
Sbjct: 548 RSSSPKRKKRHSR-SRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERER 606
Query: 401 RRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHRSSPYRERTRYSRPYTDNRARESSD 460
RR+RS SR R SR SRS DRR +R+S R R+R R D R S +
Sbjct: 607 RRNRSPSRERRRSR-----SRSR-------DRRTNRAS--RSRSRDRRKIDDQRGNLSGN 652
Query: 461 SEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKR 520
S + + + + R+ S K DR K + E ++R + + E++ K
Sbjct: 653 S-------HKHKGEAKEQERKKERSRSIDK-DRKKKDKEREREQDKRKEKQKREEKDFKF 704
Query: 521 TSENEAIKRCCSPPNELGFRRGSSYS----KHDSSASRYKST 558
+S+++ +KR +E F R S S +HDS KST
Sbjct: 705 SSQDDRLKR--KRESERTFSRSGSISVKIIRHDSRQDSKKST 744
Score = 53.9 bits (128), Expect = 2e-06
Identities = 88/354 (24%), Positives = 130/354 (36%), Gaps = 77/354 (21%)
Query: 239 KEPPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKI 298
KE + + E+ EAD T +L + + K++ G+ SS
Sbjct: 461 KEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQ---GRSRSGSSSSGS 517
Query: 299 SLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRS--HDLKFSASIEKERDFKKS-S 355
S S +T S + S S S S R+SS +R H S +I+ R +S S
Sbjct: 518 SSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYS 577
Query: 356 APLKSEDLGKPSRSKTD-RDDKYFSYSKLERDTRYVSSRCRS-ERERRRSRSHSRSERGS 413
+K E +R++ RD + + + +ER+ R R RS RERRRSRS SR R +
Sbjct: 578 RRIKIES----NRARVKIRDRRRSNRNSIERERR----RNRSPSRERRRSRSRSRDRRTN 629
Query: 414 RTNLSYSRS-----------------------------ERSHYYDSDRRYHRSSPYRE-- 442
R + S SR ERS D DR+ RE
Sbjct: 630 RASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQD 689
Query: 443 --RTRYSRPYTD----------NRARESS----------------DSEEEYKKTYSRRTS 474
+ + R D R RES DS ++ KK+ ++ +
Sbjct: 690 KRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSK 749
Query: 475 SHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEAIK 528
HS S D S S+S K + + R + K +R K+ S K
Sbjct: 750 KHSGS--DSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSK 801
Score = 40.8 bits (94), Expect = 0.017
Identities = 48/266 (18%), Positives = 102/266 (38%), Gaps = 26/266 (9%)
Query: 1900 LEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAE 1959
L K +E+ Q E V E E + +Q L + D + E + P E +
Sbjct: 436 LHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPN---ETTSV 492
Query: 1960 IEPKESNGTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDL 2019
+EPK+ + K ++ + S + S S + S +++
Sbjct: 493 LEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSP 552
Query: 2020 KEVYRIPK-----------KSQTEKENTTTERGRDAVGFRDQTPAPKTP---NRSRERDP 2065
K R + +S++ E R V RD+ + + R R R P
Sbjct: 553 KRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSP 612
Query: 2066 DKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYDTPT---------SKKKVRIKDRNKL 2116
++ + R R + S + R ++ DD+ + +K++ R K+R++
Sbjct: 613 SRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRS 672
Query: 2117 STEERRKLFEQEVAQREAQKQQQQMQ 2142
++R+K ++ +++ +K++Q+ +
Sbjct: 673 IDKDRKKKDKEREREQDKRKEKQKRE 698
Score = 39.3 bits (90), Expect = 0.050
Identities = 46/196 (23%), Positives = 77/196 (39%), Gaps = 22/196 (11%)
Query: 249 SLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSK 308
S D + + S S +I +++ ++S H G+ +E + S S K K
Sbjct: 621 SRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSH-KHKGEAKEQERKKERSRSIDKDRKK 679
Query: 309 KKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASI-------EKERDFKKS---SAPL 358
K + E ++D + + D KFS+ E ER F +S S +
Sbjct: 680 KDKER--------EREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKI 731
Query: 359 KSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSR-SHSRSERGSRTNL 417
D + S+ T +D K S S + R S S +E++ + HSRS ++
Sbjct: 732 IRHDSRQDSKKSTTKDSKKHSGS--DSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQR 789
Query: 418 SYSRSERSHYYDSDRR 433
S ++ R H S R
Sbjct: 790 SGKKASRKHKSKSRSR 805
Score = 32.7 bits (73), Expect = 4.7
Identities = 90/457 (19%), Positives = 156/457 (34%), Gaps = 56/457 (12%)
Query: 187 PSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIV 246
P PP PP + S P+ALP P +D R I
Sbjct: 188 PPGPPAPPQNRRERPSSFRDRQRSPIALP--------VKQEPPQIDAVKRRTLPAWIREG 239
Query: 247 PESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTG 306
E +E + ++ +E+ +Q+ ++ ED+ G +P SK
Sbjct: 240 LEKMEREKQKKLEKERMEQQRSQLSKKE---KKATEDAEGGDGPRLPQRSKFD------- 289
Query: 307 SKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKP 366
S ++ +E + S + Q H EKE + L +E L
Sbjct: 290 SDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEIL--- 346
Query: 367 SRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSH 426
TD + Y + +D +++ +++ + S S + G SE
Sbjct: 347 -LDVTDEEIYY-----VAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDER 400
Query: 427 YYDSDRRYHRS----SPYRERTRYSRPYTDNRARESS---DSEEEYKKTYSRRTSSHSSS 479
SDR S R R R + + +E D + E +K + R + +
Sbjct: 401 ---SDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNE 457
Query: 480 YRDLRTSSYS-----KSDRDCKTE--------TSYLEMERRGKYSSKLERESKRTSENEA 526
+ +S S ++D D E TS LE ++ K K R +S + +
Sbjct: 458 FIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGS 517
Query: 527 IKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSH 586
+ SSYS S +SR S S P K ++ + +S+
Sbjct: 518 SSSNSRTSSTSSTVSSSSYSS-SSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSY 576
Query: 587 SFSLQTPCSKG----SELRMINKNP-EREKAGSPAPS 618
S ++ ++ + R N+N ERE+ + +PS
Sbjct: 577 SRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPS 613
>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 72.0 bits (175), Expect = 7e-12
Identities = 87/342 (25%), Positives = 145/342 (42%), Gaps = 44/342 (12%)
Query: 236 RSLKEPPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDS 295
R KE ++ + E + + ++ + E + + N + + +++ D + +++ +
Sbjct: 428 RKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPN 487
Query: 296 SKISLSCKKTGSKKKSSQSE---GIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFK 352
S+ K K+K Q G S +S +S+S +S+S R
Sbjct: 488 ETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSS 547
Query: 353 KSSAPLKSEDLGKPSRSKT-----DRDDKYFSYSKLERDTRYVSSRCRS-------ERER 400
+SS+P + + + SRS T R Y K+E + V R R ERER
Sbjct: 548 RSSSPKRKKRHSR-SRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERER 606
Query: 401 RRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHRSSPYRERTRYSRPYTDNRARESSD 460
RR+RS SR R SR SRS DRR +R+S R R+R R D R S +
Sbjct: 607 RRNRSPSRERRRSR-----SRSR-------DRRTNRAS--RSRSRDRRKIDDQRGNLSGN 652
Query: 461 SEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKR 520
S + + + + R+ S K DR K + E ++R + + E++ K
Sbjct: 653 S-------HKHKGEAKEQERKKERSRSIDK-DRKKKDKEREREQDKRKEKQKREEKDFKF 704
Query: 521 TSENEAIKRCCSPPNELGFRRGSSYS----KHDSSASRYKST 558
+S+++ +KR +E F R S S +HDS KST
Sbjct: 705 SSQDDRLKR--KRESERTFSRSGSISVKIIRHDSRQDSKKST 744
Score = 53.9 bits (128), Expect = 2e-06
Identities = 88/354 (24%), Positives = 130/354 (36%), Gaps = 77/354 (21%)
Query: 239 KEPPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKI 298
KE + + E+ EAD T +L + + K++ G+ SS
Sbjct: 461 KEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQ---GRSRSGSSSSGS 517
Query: 299 SLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRS--HDLKFSASIEKERDFKKS-S 355
S S +T S + S S S S R+SS +R H S +I+ R +S S
Sbjct: 518 SSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYS 577
Query: 356 APLKSEDLGKPSRSKTD-RDDKYFSYSKLERDTRYVSSRCRS-ERERRRSRSHSRSERGS 413
+K E +R++ RD + + + +ER+ R R RS RERRRSRS SR R +
Sbjct: 578 RRIKIES----NRARVKIRDRRRSNRNSIERERR----RNRSPSRERRRSRSRSRDRRTN 629
Query: 414 RTNLSYSRS-----------------------------ERSHYYDSDRRYHRSSPYRE-- 442
R + S SR ERS D DR+ RE
Sbjct: 630 RASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQD 689
Query: 443 --RTRYSRPYTD----------NRARESS----------------DSEEEYKKTYSRRTS 474
+ + R D R RES DS ++ KK+ ++ +
Sbjct: 690 KRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSK 749
Query: 475 SHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEAIK 528
HS S D S S+S K + + R + K +R K+ S K
Sbjct: 750 KHSGS--DSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSK 801
Score = 40.8 bits (94), Expect = 0.017
Identities = 48/266 (18%), Positives = 102/266 (38%), Gaps = 26/266 (9%)
Query: 1900 LEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAE 1959
L K +E+ Q E V E E + +Q L + D + E + P E +
Sbjct: 436 LHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPN---ETTSV 492
Query: 1960 IEPKESNGTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDL 2019
+EPK+ + K ++ + S + S S + S +++
Sbjct: 493 LEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSP 552
Query: 2020 KEVYRIPK-----------KSQTEKENTTTERGRDAVGFRDQTPAPKTP---NRSRERDP 2065
K R + +S++ E R V RD+ + + R R R P
Sbjct: 553 KRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSP 612
Query: 2066 DKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYDTPT---------SKKKVRIKDRNKL 2116
++ + R R + S + R ++ DD+ + +K++ R K+R++
Sbjct: 613 SRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRS 672
Query: 2117 STEERRKLFEQEVAQREAQKQQQQMQ 2142
++R+K ++ +++ +K++Q+ +
Sbjct: 673 IDKDRKKKDKEREREQDKRKEKQKRE 698
Score = 39.3 bits (90), Expect = 0.050
Identities = 46/196 (23%), Positives = 77/196 (39%), Gaps = 22/196 (11%)
Query: 249 SLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSK 308
S D + + S S +I +++ ++S H G+ +E + S S K K
Sbjct: 621 SRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSH-KHKGEAKEQERKKERSRSIDKDRKK 679
Query: 309 KKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASI-------EKERDFKKS---SAPL 358
K + E ++D + + D KFS+ E ER F +S S +
Sbjct: 680 KDKER--------EREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKI 731
Query: 359 KSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSR-SHSRSERGSRTNL 417
D + S+ T +D K S S + R S S +E++ + HSRS ++
Sbjct: 732 IRHDSRQDSKKSTTKDSKKHSGS--DSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQR 789
Query: 418 SYSRSERSHYYDSDRR 433
S ++ R H S R
Sbjct: 790 SGKKASRKHKSKSRSR 805
Score = 32.7 bits (73), Expect = 4.7
Identities = 90/457 (19%), Positives = 156/457 (34%), Gaps = 56/457 (12%)
Query: 187 PSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIV 246
P PP PP + S P+ALP P +D R I
Sbjct: 188 PPGPPAPPQNRRERPSSFRDRQRSPIALP--------VKQEPPQIDAVKRRTLPAWIREG 239
Query: 247 PESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTG 306
E +E + ++ +E+ +Q+ ++ ED+ G +P SK
Sbjct: 240 LEKMEREKQKKLEKERMEQQRSQLSKKE---KKATEDAEGGDGPRLPQRSKFD------- 289
Query: 307 SKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKP 366
S ++ +E + S + Q H EKE + L +E L
Sbjct: 290 SDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEIL--- 346
Query: 367 SRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSH 426
TD + Y + +D +++ +++ + S S + G SE
Sbjct: 347 -LDVTDEEIYY-----VAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDER 400
Query: 427 YYDSDRRYHRS----SPYRERTRYSRPYTDNRARESS---DSEEEYKKTYSRRTSSHSSS 479
SDR S R R R + + +E D + E +K + R + +
Sbjct: 401 ---SDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNE 457
Query: 480 YRDLRTSSYS-----KSDRDCKTE--------TSYLEMERRGKYSSKLERESKRTSENEA 526
+ +S S ++D D E TS LE ++ K K R +S + +
Sbjct: 458 FIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGS 517
Query: 527 IKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSH 586
+ SSYS S +SR S S P K ++ + +S+
Sbjct: 518 SSSNSRTSSTSSTVSSSSYSS-SSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSY 576
Query: 587 SFSLQTPCSKG----SELRMINKNP-EREKAGSPAPS 618
S ++ ++ + R N+N ERE+ + +PS
Sbjct: 577 SRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPS 613
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 70.9 bits (172), Expect = 2e-11
Identities = 117/468 (25%), Positives = 170/468 (36%), Gaps = 62/468 (13%)
Query: 194 PPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVP--ESLE 251
PP SS VT A TP + P + R +K +I+P E
Sbjct: 198 PPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSY 257
Query: 252 ADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKS 311
+ T+ + S + T+ + S S G + + S S K+ S+ +S
Sbjct: 258 SPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVR-SHSWKRNHSRARS 316
Query: 312 SQSEGIF--LGSESDEDS---------------------VRTSSSQRSHDLKFSASIEKE 348
+GI +G S S R S +RSH S S KE
Sbjct: 317 RTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHS--HSRSSSKE 374
Query: 349 RDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSE---RERRRSRS 405
RD + SS+P K + RD RD SR RS R+R RSRS
Sbjct: 375 RDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDR----SRSRSPYKARDRSRSRS 430
Query: 406 HSRSERGSRTNLSYSRSERSHYYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEY 465
+++ SR+ Y +RS SP + R +SR + N+AR+ S S
Sbjct: 431 PNKARDCSRSRSPYKARDRSR---------SRSPNKARD-HSRSRSPNKARDRSRSRSPS 480
Query: 466 K-----------KTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETS-YLEMERRGKYSSK 513
K K R S S R R S S +RD + S E +RR S
Sbjct: 481 KERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPN 540
Query: 514 LER---ESKRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKS-DKF 569
ER +S+ SE ++ SP E RR S SK S+ + +S
Sbjct: 541 KERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPN 600
Query: 570 KNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPAP 617
K S +++HS S +TP +G+ + + E + + S P
Sbjct: 601 KQSGYSRPRASSKEKAHSRS-RTPSKEGNHSQSRTSSKESDPSQSTVP 647
Score = 64.3 bits (155), Expect = 1e-09
Identities = 78/326 (23%), Positives = 123/326 (37%), Gaps = 14/326 (4%)
Query: 251 EADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKK 310
E+ Q N +H +A S+ + +D S + C ++ S K
Sbjct: 386 ESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYK 445
Query: 311 SSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSRSK 370
+ + D R+ S ++ D S S KERD + +P K D +
Sbjct: 446 A-RDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPS 504
Query: 371 TDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRS----HSRSERGSRTNLSYSRSERSH 426
+R + S ERD R S + ER+RR+SRS RS+ S + R RS
Sbjct: 505 KERQCRQSRSSSKERDHRRSRSPSK-ERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSP 563
Query: 427 YYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSR-----RTSSHSSSYR 481
+ DRR RS R SR ++ R S S + + YSR + +HS S
Sbjct: 564 SKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNK-QSGYSRPRASSKEKAHSRSRT 622
Query: 482 DLRTSSYSKSDRDCK-TETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFR 540
+ ++S+S K ++ S + R + R S + K P+
Sbjct: 623 PSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFP-S 681
Query: 541 RGSSYSKHDSSASRYKSTLSKPIPKS 566
G + S+ DS A S + P +S
Sbjct: 682 GGQTLSQDDSQADATTSKATLPGERS 707
Score = 62.4 bits (150), Expect = 6e-09
Identities = 71/243 (29%), Positives = 99/243 (40%), Gaps = 33/243 (13%)
Query: 304 KTGSKKKSSQSEGIFLGSESDE-DSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSED 362
++ S+ S + + LGS S E D R+ S + + S S KERD ++S +P K E
Sbjct: 473 RSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSK-ER 531
Query: 363 LGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHS-----RSERGSRTNL 417
+ SRS D+ S S E S ER+RRR RS S R R S
Sbjct: 532 QRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEER 591
Query: 418 SYSRSERSHYYDSDRRYHRSSPYRERTRYSRPYTD---NRARESSDSEEEYKKTYSR--- 471
+SRS + R SS + +R P + +++R SS + + T R
Sbjct: 592 DHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPD 651
Query: 472 ------RTSSHSSSYRDLRTSSYS--------------KSDRDCKTETSYLEMERRGKYS 511
RTSS S + +TSS+S S D T + L ER S
Sbjct: 652 WKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSS 711
Query: 512 SKL 514
SKL
Sbjct: 712 SKL 714
Score = 55.5 bits (132), Expect = 7e-07
Identities = 110/510 (21%), Positives = 185/510 (36%), Gaps = 67/510 (13%)
Query: 152 TSRPLLATTTAVASPPTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEP 211
+S+P ++ + +S PT A P P +ST +P S P P ++ SP+
Sbjct: 7 SSKPSMSLAPSGSSMPT-ADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPS----- 60
Query: 212 VALPHTPITVLMAAPVPLPVDVA-VRSLKEPPIIIVPESLEADTKQDTISNSLEEHVTQ- 269
+ T T AP P + VRS P + DT+ S + + Q
Sbjct: 61 -SSKSTKSTSTKRAPSNRPSSRSRVRSKAR-----TPSRVSTDTRTSKASKASDVRCHQR 114
Query: 270 --------ILNEQADISSKKEDSHIGKDEEI-PDSSKISLSCKKTGSKKKSSQSEGIFLG 320
+ SSK+ S I ++ ++ + + S G G
Sbjct: 115 RGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYG 174
Query: 321 SESDEDSVRTSS-----SQRSHDLKFSASIEKERDFKKSSAPLKSE-DLGKPSRSKTDR- 373
+ R+ S S++S+ + I + + + + K + G PS+ K+D
Sbjct: 175 RPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNP 234
Query: 374 ----------------DDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNL 417
+ SYS E +R S S R R +S S SRS R SR+
Sbjct: 235 SPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGS 294
Query: 418 SYSRSERSHYYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHS 477
R + R + R+ + S+ +++R S + + + RR SH+
Sbjct: 295 QKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHN 354
Query: 478 SSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNEL 537
S + S+S S +S E + RG SS +ES R+ SP +
Sbjct: 355 WSRNPSKERSHSHS------RSSSKERDHRG--SSSPRKESGRSQSG-------SPNKQR 399
Query: 538 GFRRGSSYSK-HDSSASR--YKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPC 594
R S +K D S SR YK+ +K ++ C+ K ++P
Sbjct: 400 DHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARD---CSRSRSPYKARDRSRSRSPN 456
Query: 595 SKGSELRMINKNPEREKAGSPAPSNRLNDS 624
R + N R+++ S +PS + S
Sbjct: 457 KARDHSRSRSPNKARDRSRSRSPSKERDHS 486
Score = 33.9 bits (76), Expect = 2.1
Identities = 28/134 (20%), Positives = 56/134 (41%), Gaps = 10/134 (7%)
Query: 2024 RIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNR-----SRERDPDKQTQNKEKRKRR 2078
R P K + + + + RD R ++P+ + R S+ERD + ++R+RR
Sbjct: 477 RSPSKERDHSQLGSPSKERDHR--RSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRR 534
Query: 2079 SSLSPPSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKL---STEERRKLFEQEVAQREAQ 2135
S SP ++ P + + S+ + +DR + S E R+ +R+
Sbjct: 535 QSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHS 594
Query: 2136 KQQQQMQNLGMTSP 2149
+ + + G + P
Sbjct: 595 RSRSPNKQSGYSRP 608
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 68.9 bits (167), Expect = 6e-11
Identities = 96/474 (20%), Positives = 194/474 (40%), Gaps = 56/474 (11%)
Query: 1703 KMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVR-IETL--EQKLTCLELIQ 1759
++K+E K ++D +++ ++E LS+ Q ++ + ++ +ET+ QK+ C
Sbjct: 1083 QLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVEC----- 1137
Query: 1760 NTHSQSCLKSFLERHGLSL-----LWIWMAELGDGRESNQKLQEEIIKTLEHLPIPTKNM 1814
+HS + LE+ + L L + L D ++ + L + +K E + T N+
Sbjct: 1138 -SHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNL 1196
Query: 1815 LEESKVLPIIQRWSQT-KTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTP 1873
+ +L + + +T + L E SS T L + E TD
Sbjct: 1197 QDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAK 1256
Query: 1874 KKLMFRRLKIISENSMDSAISDATSELEGKDGK--EDLDQLENVPVEEEEELQSQQL--- 1928
K++ + ++ D + +ELE K + ++LD + + +E+L +Q++
Sbjct: 1257 KQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEA 1316
Query: 1929 LPQQLPECK-VDSETNIEASKLPTSEPEADAEIEPKESNGTKLEEPINEETPSQDEEEGV 1987
+ Q CK ++ + I T E + ++E + KLEE T + +E
Sbjct: 1317 IQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKC 1376
Query: 1988 SDVESE---RSQEQPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKENTTTERGRDA 2044
+D+E++ RS ++ + D+ T L D ++ ++ Y +K E++ + ++A
Sbjct: 1377 NDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEA 1436
Query: 2045 VGFRDQTPAPKTPNRSR----------------ERDPDKQTQNKEKRKRRSSLSPPSSAY 2088
R++ +R R E+D D Q +E+ + ++L A
Sbjct: 1437 ENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKAL 1496
Query: 2089 ERGTKRPDD------RYDTPTSK----------KKVRIKDRNKLSTEERRKLFE 2126
+ D+ R + TSK K++ D +KL TE FE
Sbjct: 1497 ISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFE 1550
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
sapiens]
Length = 916
Score = 67.8 bits (164), Expect = 1e-10
Identities = 96/463 (20%), Positives = 197/463 (42%), Gaps = 47/463 (10%)
Query: 1720 EALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHS--QSCLKSFLERHGLS 1777
EA +N E + + ++ R ++ +++E LE ++ T + L ERH
Sbjct: 301 EAAEQNKEAIRSAKEEIAEYRRQLQSKSIE-----LESVRGTKESLERQLSDIEERHN-- 353
Query: 1778 LLWIWMAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPL 1837
+L +++ Q+L+ E+ T + +++ E +L + A L
Sbjct: 354 ------HDLSSYQDTIQQLENELRGTKWEM---ARHLREYQDLLNVKMALDIEIAAYRKL 404
Query: 1838 SEGDGYSSENTSRAHT-PLNTPDPSTKLSTEAD---TDTPK--------KLMFRRLKIIS 1885
EG+ + + T PL T P +S++ + PK + + K+
Sbjct: 405 LEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVED 464
Query: 1886 ENS-MDSAISDATSELE---GKDGKEDLDQLENVPVEEEEELQSQQL-LPQQLPECKVDS 1940
E S M+ A++ T EL ++ KE ++ E P EEEE+ +++ + PE K +
Sbjct: 465 EKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEE 524
Query: 1941 -ETNIEASKLPTSEPEADAEIEPKESNGTKLEEPINEETPSQDEEEGVSDVESERSQEQP 1999
E E + E + A+ + E G++ E +E Q+E E ++ E E ++ +
Sbjct: 525 GEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKE 584
Query: 2000 DKTVD--ISDLATK---LLDSWKDLKEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAP 2054
+K V+ ++ATK + D+ + E + P +E + + V + ++P P
Sbjct: 585 EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP 644
Query: 2055 KTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYDTPTSKKKVRIKDRN 2114
K+P + + P ++ +EK K S SP E K P + +K K +
Sbjct: 645 KSPVEEKGKSPVPKSPVEEKGKSPVSKSP----VEEKAKSPVPKSPVEEAKSKAEVGKGE 700
Query: 2115 KLSTEER--RKLFEQEVAQREAQKQQQQMQNLGMTSPLPYDSL 2155
+ EE+ ++ ++E +++ +K + + SP+ +++
Sbjct: 701 QKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV 743
Score = 37.7 bits (86), Expect = 0.15
Identities = 57/267 (21%), Positives = 108/267 (40%), Gaps = 24/267 (8%)
Query: 1838 SEGDGYSSENTSRAHTPLNTPDPSTK--LSTEADTDTPKKLMFRRLKIISENSMDSAISD 1895
+E +G +E + + +TK L +A + P+K K E S +
Sbjct: 573 AEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPK 632
Query: 1896 ATSELEGKDG--KEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSE 1953
+ E +GK K +++ PV + + + + P V+ + K P E
Sbjct: 633 SPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP---VEEKAKSPVPKSPVEE 689
Query: 1954 PEADAEI---EPKESNGTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLAT 2010
++ AE+ E KE +++E EE + EE+ DV ++ E P K ++++ T
Sbjct: 690 AKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP-KDVPEKKKAESPVKEEAVAEVVT 748
Query: 2011 ----KLLDSWKDLKEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERD-- 2064
+ K+ KE + P + + EKE E G + G + K SR+ D
Sbjct: 749 ITKSVKVHLEKETKEEGK-PLQQEKEKEKAGGEGGSEEEG------SDKGAKGSRKEDIA 801
Query: 2065 PDKQTQNKEKRKRRSSLSPPSSAYERG 2091
+ + + KE+ ++ + E+G
Sbjct: 802 VNGEVEGKEEVEQETKEKGSGREEEKG 828
Score = 33.5 bits (75), Expect = 2.8
Identities = 59/260 (22%), Positives = 98/260 (37%), Gaps = 29/260 (11%)
Query: 117 KMEIGDTLSTAE-ESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPA 175
+ E G+T + AE E + K E K+ K V ++ L V P +P+P
Sbjct: 565 EQEEGETEAEAEGEEAEAK---EEKKVEEKSE--EVATKEELVADAKVEKPEKAKSPVPK 619
Query: 176 VIAESTTVDSPPSSP-------PPPPPPAQATTLSS--PAPVTEPVALPHTPITVLMAAP 226
E P SP P P P + S +PV E P + V A
Sbjct: 620 SPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAK 679
Query: 227 VPLPVDVAVRSLKEPPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHI 286
P+P V K + E E + K+ + EE V + + D+ KK+
Sbjct: 680 SPVPKS-PVEEAKSKAEVGKGEQKEEEEKEVKEAPK-EEKVEKKEEKPKDVPEKKKAESP 737
Query: 287 GKDEEIPDSSKISLSCK-----------KTGSKKKSSQSEGIFLGSESDEDSVRTSSSQR 335
K+E + + I+ S K K ++K + G GSE +E S + + R
Sbjct: 738 VKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSE-EEGSDKGAKGSR 796
Query: 336 SHDLKFSASIEKERDFKKSS 355
D+ + +E + + ++ +
Sbjct: 797 KEDIAVNGEVEGKEEVEQET 816
Score = 32.0 bits (71), Expect = 8.1
Identities = 39/175 (22%), Positives = 74/175 (42%), Gaps = 16/175 (9%)
Query: 208 VTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQDTISNSLEEHV 267
+T P+ PIT+ P V LK + E + +TK + + +EE +
Sbjct: 419 ITGPLYTHRPPITISSKIQKP---KVEAPKLKVQHKFV--EEIIEETKVEDEKSEMEEAL 473
Query: 268 TQILNEQADISSKKEDSHIGKD-EEIPDSSKISLSCKKTGSK--------KKSSQSEGIF 318
T I E A +S K+E ++ EE P++ + ++ KK+ K ++ + E
Sbjct: 474 TAITEELA-VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEG 532
Query: 319 LGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSRSKTDR 373
E +ED S + S EKE + ++ ++E G+ + +K ++
Sbjct: 533 QEEEEEEDEGAKSDQAEEGGSEKEGSSEKE-EGEQEEGETEAEAEGEEAEAKEEK 586
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.127 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 111,859,006
Number of Sequences: 37866
Number of extensions: 6079726
Number of successful extensions: 54890
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 369
Number of HSP's successfully gapped in prelim test: 1323
Number of HSP's that attempted gapping in prelim test: 31075
Number of HSP's gapped (non-prelim): 16738
length of query: 2564
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2445
effective length of database: 13,741,464
effective search space: 33597879480
effective search space used: 33597879480
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.