Search of human proteins with 194018524

Search of human proteins with 194018524

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
         (628 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194018524 solute carrier family 6, member 18 [Homo sapiens]       1305   0.0  
gi|51468073 solute carrier family 6, member 19 [Homo sapiens]         695   0.0  
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...   603   e-172
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...   533   e-151
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...   516   e-146
gi|58219014 solute carrier family 6, member 17 [Homo sapiens]         501   e-141
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...   440   e-123
gi|92859670 solute carrier family 6 (neurotransmitter transporte...   390   e-108
gi|188528618 solute carrier family 6 (neurotransmitter transport...   385   e-107
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...   383   e-106
gi|134304856 solute carrier family 6, member 7 [Homo sapiens]         382   e-106
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   373   e-103
gi|171184408 solute carrier family 6 (neurotransmitter transport...   372   e-103
gi|171184406 solute carrier family 6 (neurotransmitter transport...   372   e-103
gi|171184404 solute carrier family 6 (neurotransmitter transport...   372   e-103
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...   365   e-101
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...   365   e-101
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...   365   e-101
gi|21361581 solute carrier family 6 (neurotransmitter transporte...   362   e-100
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...   361   1e-99
gi|4507043 solute carrier family 6 member 4 [Homo sapiens]            358   8e-99
gi|4557046 solute carrier family 6 member 2 [Homo sapiens]            354   1e-97
gi|197276623 solute carrier family 6 (neurotransmitter transport...   353   3e-97
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   353   3e-97
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   352   5e-97
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   340   2e-93
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         327   2e-89
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...   300   3e-81
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   242   7e-64
gi|197276625 solute carrier family 6 (neurotransmitter transport...   138   2e-32

>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score = 1305 bits (3377), Expect = 0.0
 Identities = 628/628 (100%), Positives = 628/628 (100%)

Query: 1   MAHAPEPDPAACDLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPY 60
           MAHAPEPDPAACDLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPY
Sbjct: 1   MAHAPEPDPAACDLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPY 60

Query: 61  VIALVFEGIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVA 120
           VIALVFEGIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVA
Sbjct: 61  VIALVFEGIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVA 120

Query: 121 WVLWYLLNSFQHPLPWSSCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQ 180
           WVLWYLLNSFQHPLPWSSCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQ
Sbjct: 121 WVLWYLLNSFQHPLPWSSCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQ 180

Query: 181 WWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYL 240
           WWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYL
Sbjct: 181 WWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYL 240

Query: 241 FTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTS 300
           FTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTS
Sbjct: 241 FTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTS 300

Query: 301 LYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKR 360
           LYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKR
Sbjct: 301 LYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKR 360

Query: 361 VAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFG 420
           VAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFG
Sbjct: 361 VAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFG 420

Query: 421 TVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNL 480
           TVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNL
Sbjct: 421 TVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNL 480

Query: 481 LMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFW 540
           LMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFW
Sbjct: 481 LMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFW 540

Query: 541 KPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRRRRTWRD 600
           KPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRRRRTWRD
Sbjct: 541 KPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRRRRTWRD 600

Query: 601 RDARPDTDMRPDTDTRPDTDMRPDTDMR 628
           RDARPDTDMRPDTDTRPDTDMRPDTDMR
Sbjct: 601 RDARPDTDMRPDTDTRPDTDMRPDTDMR 628


>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score =  695 bits (1794), Expect = 0.0
 Identities = 317/575 (55%), Positives = 429/575 (74%), Gaps = 1/575 (0%)

Query: 18  RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELA 77
           RPKWDNKAQY+L+C GF VGLGN+WRFPYLCQ++GGGAF+IP++I LV EGIP+ ++E A
Sbjct: 32  RPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFA 91

Query: 78  IGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWS 137
           IGQRLR+GS+GVW++I P L G+GL  +  SF++ LYYNTI++W++WYL NSFQ PLPWS
Sbjct: 92  IGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWS 151

Query: 138 SCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMC 197
            CP + N+TG+V+EC  SS V YFWYR+TLNI+  I+DSGSIQWW+L+CLA +W+V+YMC
Sbjct: 152 DCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMC 211

Query: 198 VIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDA 257
            IRGIETTGK +Y T+  PY+VLTIFLIRGLTL GAT G+++LFTPN+  L  P  WLDA
Sbjct: 212 TIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDA 271

Query: 258 ATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATN 317
             Q+FFS SLAFGG I+F+SYNS  N+C+KD+V+++++N  TS+Y +I V+SV+GF+AT 
Sbjct: 272 GAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQ 331

Query: 318 DYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDK 377
            Y+ C   NIL+LIN FD PE +++++++  +    NA+ P   AQL  + C +  FL +
Sbjct: 332 RYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSE 391

Query: 378 SASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPR 437
           +  G GLAF+VFTE    MP +P+W++LFF MLF LGLS+MFG +E V+ PL D+ V+P 
Sbjct: 392 AVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPP 451

Query: 438 WVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYGM 497
             PKE LTGL+CL  FL    FTL SG YWL + D++A S  LL++AF E+  VVYVYG+
Sbjct: 452 KWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGV 511

Query: 498 KRFCDDIAWMTGRRPSPYWRLTWRVVSPLL-LTIFVAYIILLFWKPLRYKAWNPKYELFP 556
            RF  DI +M G +P+ +W++TWRVVSPLL L IF+ + ++   + L Y  W+P YE FP
Sbjct: 512 DRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFP 571

Query: 557 SRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLL 591
             Q+  YP W     V+++ +P L +P  A+ +L+
Sbjct: 572 KSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLI 606


>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  603 bits (1556), Expect = e-172
 Identities = 281/581 (48%), Positives = 403/581 (69%), Gaps = 7/581 (1%)

Query: 18  RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELA 77
           RP W N  Q++ +C  +AVGLGN+WRFPYLCQ YGGG+FL+PY+I L+ EG+P+ ++ELA
Sbjct: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64

Query: 78  IGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWS 137
           +GQR+R+GS+G W  ISPYLSGVG+  V +SF +S+YYN I AW  WYL +SFQ PLPWS
Sbjct: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124

Query: 138 SCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMC 197
            CP + N TG+ EEC+ +S+  YFWYR+TLNI+  + ++G +QW   +CL  +W VVY+C
Sbjct: 125 VCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLC 184

Query: 198 VIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDA 257
           ++RG E+TGKV+YFTA  PY VL I+LIRGLTL GAT GL+Y+FTP +  L NP+ W++A
Sbjct: 185 ILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWINA 244

Query: 258 ATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATN 317
           ATQIFFSL L FG  IAFASYN P N+CQK A++++L+N  TS++ASI  FS+ GFKAT 
Sbjct: 245 ATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATF 304

Query: 318 DYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQL--PLKACLLEDFL 375
           +YE+CL +  L L N FD  +  ++  +   V  +L + +P + +++   +K C LE  L
Sbjct: 305 NYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESEL 364

Query: 376 DKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVL 435
           D +  G GLAF+V+TE   +M  + +W++L+F ML  LG+ +M G   A++TPL D  ++
Sbjct: 365 DTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKII 424

Query: 436 PRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVY 495
              +PKEA++GLVCLV       FT+++GNYW +IF+++AA+ +LL++  +E + V YVY
Sbjct: 425 SSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVY 484

Query: 496 GMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLL-TIFVAYII-LLFWKPLRYKAWNPKYE 553
           G++RF  D+  MTGR  S YW++ W  VSPLL+ ++FV Y+   +    L+Y+AW+    
Sbjct: 485 GLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQG 544

Query: 554 LFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRR 594
              ++    YP +A A   LL     + +P+AAL   + RR
Sbjct: 545 QLVTKD---YPAYALAVIGLLVASSTMCIPLAALGTFVQRR 582


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score =  533 bits (1373), Expect = e-151
 Identities = 255/581 (43%), Positives = 373/581 (64%), Gaps = 44/581 (7%)

Query: 18  RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELA 77
           RP W N  Q++ +C  +AVGLGN+WRFPYLCQ YGGG+FL+PY+I L+ EG+P+ ++ELA
Sbjct: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64

Query: 78  IGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWS 137
           +GQR+R+GS+G W  ISPYLSGVG+  V +SF +S+YYN I AW  WYL +SFQ PLPWS
Sbjct: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124

Query: 138 SCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMC 197
            CP + N TG+ EEC+ +S+  YFWYR+TLNI+  + ++G +QW   +CL  +W VVY+C
Sbjct: 125 VCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLC 184

Query: 198 VIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDA 257
           ++RG E+TGK+                                       L NP+ W++A
Sbjct: 185 ILRGTESTGKI-------------------------------------EQLANPKAWINA 207

Query: 258 ATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATN 317
           ATQIFFSL L FG  IAFASYN P N+CQK A++++L+N  TS++ASI  FS+ GFKAT 
Sbjct: 208 ATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATF 267

Query: 318 DYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQL--PLKACLLEDFL 375
           +YE+CL +  L L N FD  +  ++  +   V  +L + +P + +++   +K C LE  L
Sbjct: 268 NYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESEL 327

Query: 376 DKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVL 435
           D +  G GLAF+V+TE   +M  + +W++L+F ML  LG+ +M G   A++TPL D  ++
Sbjct: 328 DTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKII 387

Query: 436 PRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVY 495
              +PKEA++GLVCLV       FT+++GNYW +IF+++AA+ +LL++  +E + V YVY
Sbjct: 388 SSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVY 447

Query: 496 GMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLL-TIFVAYII-LLFWKPLRYKAWNPKYE 553
           G++RF  D+  MTGR  S YW++ W  VSPLL+ ++FV Y+   +    L+Y+AW+    
Sbjct: 448 GLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQG 507

Query: 554 LFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRR 594
              ++    YP +A A   LL     + +P+AAL   + RR
Sbjct: 508 QLVTKD---YPAYALAVIGLLVASSTMCIPLAALGTFVQRR 545


>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score =  516 bits (1330), Expect = e-146
 Identities = 252/592 (42%), Positives = 380/592 (64%), Gaps = 22/592 (3%)

Query: 13  DLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIF 72
           ++ DERP W++K QY+L+  GF+VGLGN+WRFPYLCQ  GGGA+L+PY+I L+  GIP+F
Sbjct: 56  EVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLF 115

Query: 73  HVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQH 132
            +EL++GQR+R+GS+GVW  ISP L G+G     + + ++LYYN I+ W L+Y   SFQ 
Sbjct: 116 FLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQ 175

Query: 133 PLPWSSCPPDLNRTG-FVE-ECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAAS 190
           PLPW  CP   N +  FVE EC+ SSA +Y+WYR+ LNI++ I++SG + W + ICL A+
Sbjct: 176 PLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAA 235

Query: 191 WAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQN 250
           W +V + +I+GI+++GK+IYF++LFPY+VL  FLIR   L G+  G+ ++FTP + I+  
Sbjct: 236 WVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLE 295

Query: 251 PRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSV 310
           P+VW +AATQ+FF+L L FGG IAF+SYN   N+C  DAV+++ +N  TS+ A++ VF+V
Sbjct: 296 PKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAV 355

Query: 311 LGFKATNDYEHCLDRNILSLINDFDFPE------------QSISRDDYPAVLMHLNATWP 358
           LGFKA    E C+ +N  +++                    +++ +DY  V   +     
Sbjct: 356 LGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKE 415

Query: 359 KRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTM 418
           +    L L +C +E+ L+K+  G GLAF+ FTE   H P +P W+++FF ML  LGL +M
Sbjct: 416 EEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSM 475

Query: 419 FGTVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASP 478
           FGT+E ++TP++D       V KE LT + CL+ F     F  +SGNY++ +FD+++A+ 
Sbjct: 476 FGTIEGIVTPIVDTFK----VRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATL 531

Query: 479 NLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPL-LLTIFVAYIIL 537
            LL++  LE + V +VYG+ +F +D+  M G  PS Y+   W+ +SPL LL++ +A ++ 
Sbjct: 532 PLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVN 591

Query: 538 LFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQ 589
           +   P  Y AW    E   S +   YP W    CV L +  +L VPV  + +
Sbjct: 592 MGLSPPGYNAW---IEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 640


>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score =  501 bits (1289), Expect = e-141
 Identities = 250/584 (42%), Positives = 367/584 (62%), Gaps = 22/584 (3%)

Query: 16  DERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVE 75
           ++RP W++K QY+L+  GF+VGLGNIWRFPYLCQ  GGGA+L+PY++ L+  GIP+F +E
Sbjct: 58  EDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLE 117

Query: 76  LAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLP 135
           LA+GQR+R+GS+GVW  I P L G+G     +   + LYYN I+ W ++Y   SFQ+PLP
Sbjct: 118 LAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLP 177

Query: 136 WSSCPPDLNRTGFV--EECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAV 193
           WS CP   N +  V   EC+ SSA +YFWYR+ L+I+  I++SG + W + +CL  +W++
Sbjct: 178 WSECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSI 237

Query: 194 VYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRV 253
           V M V++GI+++GKV+YF++LFPY+VL  FL+RGL L GA  G++++FTP +  + +P+V
Sbjct: 238 VGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQV 297

Query: 254 WLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGF 313
           W +AATQ+FF+L L FGG IAF+SYN   N+C  DA +++ +N  TS+ A++ VF+VLGF
Sbjct: 298 WREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGF 357

Query: 314 KATNDYEHCLDRN---ILSLIN------DFDFPEQSISR---DDYPAVLMHLNATWPKRV 361
           KA    E C+  N   IL  +N      D   P  + S     DY  +   +      + 
Sbjct: 358 KANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQF 417

Query: 362 AQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGT 421
           + L L  CLLED LDKS  G GLAF+ FTE   H P +P W+++FF ML  LGL +M GT
Sbjct: 418 SALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGT 477

Query: 422 VEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLL 481
           +  + TP++D       VPKE  T   C+  FL    F  +SGNY++ +FD+++A+  L 
Sbjct: 478 MAGITTPIIDTFK----VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLT 533

Query: 482 MLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIF-VAYIILLFW 540
           ++  LE + V ++YG K+F  ++  M G RP  ++   W+ VSPL + +   A II L  
Sbjct: 534 LIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGV 593

Query: 541 KPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPV 584
            P  Y AW  +     + +   +P WA A  + L ++  L +PV
Sbjct: 594 TPPGYSAWIKEE---AAERYLYFPNWAMALLITLIVVATLPIPV 634


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score =  440 bits (1131), Expect = e-123
 Identities = 219/537 (40%), Positives = 335/537 (62%), Gaps = 22/537 (4%)

Query: 68  GIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLL 127
           GIP+F +EL++GQR+R+GS+GVW  ISP L G+G     + + ++LYYN I+ W L+Y  
Sbjct: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63

Query: 128 NSFQHPLPWSSCPPDLNRTG-FVE-ECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLI 185
            SFQ PLPW  CP   N +  FVE EC+ SSA +Y+WYR+ LNI++ I++SG + W + I
Sbjct: 64  QSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTI 123

Query: 186 CLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNM 245
           CL A+W +V + +I+GI+++GK+IYF++LFPY+VL  FLIR   L G+  G+ ++FTP +
Sbjct: 124 CLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKL 183

Query: 246 HILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASI 305
            I+  P+VW +AATQ+FF+L L FGG IAF+SYN   N+C  DAV+++ +N  TS+ A++
Sbjct: 184 EIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATL 243

Query: 306 AVFSVLGFKATNDYEHCLDRNILSLINDFDFPE------------QSISRDDYPAVLMHL 353
            VF+VLGFKA    E C+ +N  +++                    +++ +DY  V   +
Sbjct: 244 VVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDII 303

Query: 354 NATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTL 413
                +    L L +C +E+ L+K+  G GLAF+ FTE   H P +P W+++FF ML  L
Sbjct: 304 QKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNL 363

Query: 414 GLSTMFGTVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDN 473
           GL +MFGT+E ++TP++D       V KE LT + CL+ F     F  +SGNY++ +FD+
Sbjct: 364 GLGSMFGTIEGIVTPIVDTFK----VRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDD 419

Query: 474 FAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPL-LLTIFV 532
           ++A+  LL++  LE + V +VYG+ +F +D+  M G  PS Y+   W+ +SPL LL++ +
Sbjct: 420 YSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLI 479

Query: 533 AYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQ 589
           A ++ +   P  Y AW    E   S +   YP W    CV L +  +L VPV  + +
Sbjct: 480 ASVVNMGLSPPGYNAW---IEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 533


>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score =  390 bits (1003), Expect = e-108
 Identities = 223/617 (36%), Positives = 322/617 (52%), Gaps = 117/617 (18%)

Query: 15  GDE---RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPI 71
           GDE   R  W +K  ++LS  G+AVGLGN+WRFPYL    GGGAFLIPY++ L   G+PI
Sbjct: 185 GDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPI 244

Query: 72  FHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQ 131
           F +E+++GQ   +G V VW AI P L G G+  + +S LI++YYN I+ + L+YL  SF 
Sbjct: 245 FFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFV 303

Query: 132 HPLPWSSCP---------------------------------------PDLNRTGFVEEC 152
             LPW SC                                        P++    F  + 
Sbjct: 304 SVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQA 363

Query: 153 QG---SSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVI 209
                S +  YF Y   L I+A I   G I+W L +CL  +W +VY  + +GI+T+GKV+
Sbjct: 364 NKTFVSGSEEYFKYF-VLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVV 422

Query: 210 YFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAF 269
           YFTA FPY+VL I LIRG+TLPGA  G+ Y  TP    L +  VW DAATQIFFSLS A+
Sbjct: 423 YFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAW 482

Query: 270 GGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILS 329
           GG I  +SYN   N+C +D +++   N  TS++A   +FSV+GF A              
Sbjct: 483 GGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAN------------- 529

Query: 330 LINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVF 389
                   E+ ++                            +E+  D+   GPG+AFVV+
Sbjct: 530 --------ERKVN----------------------------IENVADQ---GPGIAFVVY 550

Query: 390 TETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPRWV--PKEALTGL 447
            E    +P +P WA++FF ML TLGL TMF T+E ++T + D    P+++   K   T  
Sbjct: 551 PEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISD--EFPKYLRTHKPVFTLG 608

Query: 448 VCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWM 507
            C+  F+       Q G Y  ++ D +AAS  L+++A  E+VG+ YVYG++RFC+DI  M
Sbjct: 609 CCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMM 668

Query: 508 TGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWA 567
            G +P+ +W++ W  V+P +LT F+       W+P+ Y ++              YP W+
Sbjct: 669 IGFQPNIFWKVCWAFVTPTILT-FILCFSFYQWEPMTYGSYR-------------YPNWS 714

Query: 568 RAACVLLSLLPVLWVPV 584
                L+    V+W+P+
Sbjct: 715 MVLGWLMLACSVIWIPI 731


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  385 bits (988), Expect = e-107
 Identities = 204/527 (38%), Positives = 291/527 (55%), Gaps = 65/527 (12%)

Query: 11  ACDLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIP 70
           A DL D R  W  +  +L+SC G+A+GLGN+WRFPYLC   GGGAFLIPY + L+F G+P
Sbjct: 38  AADLPD-RDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVP 96

Query: 71  IFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSF 130
           +F +E ++GQ    G +GVW  ++P   GVGL    LSF +++YY  I++W ++YL NSF
Sbjct: 97  LFLLECSLGQYTSIGGLGVWK-LAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSF 155

Query: 131 QHPLPWSSCPPDLNRT------GFVEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLL 184
              LPW  C    N          V     +SAV  FW R    +T  ++  G I+W L 
Sbjct: 156 TTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLA 215

Query: 185 ICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPN 244
           I LA +W +VY C+ +G+  TGKV+YF+A +PY++L I   RG+TLPGA +G+++  TPN
Sbjct: 216 ITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPN 275

Query: 245 MHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYAS 304
              L +  VWLDAATQIFFS  L  G  IA  SYNS  N+  +D++++  +N  TS++A 
Sbjct: 276 FRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAG 335

Query: 305 IAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQL 364
             +FS++GF A     H   R+I                                     
Sbjct: 336 FVIFSIVGFMA-----HVTKRSI------------------------------------- 353

Query: 365 PLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEA 424
                      D +ASGPGLAF+ + E    +P +P+WA+LFF ML  LG+ + F TVE 
Sbjct: 354 ----------ADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEG 403

Query: 425 VITPLLDVGVLPRWV--PKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAAS-PNLL 481
            IT L+D    PR +   +E     VC++ +L       Q G Y  ++FD ++AS  +LL
Sbjct: 404 FITALVD--EYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLL 461

Query: 482 MLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLL 528
            L F E V + + YG+ RF D+I  M G RP  +W+L W   +P+++
Sbjct: 462 FLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIV 508


>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score =  383 bits (984), Expect = e-106
 Identities = 224/609 (36%), Positives = 316/609 (51%), Gaps = 95/609 (15%)

Query: 18  RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELA 77
           R  W  +  +++SC GFAVGLGN+WRFPYLC   GGG FLIPYV+  +  GIPIF +E++
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 78  IGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWS 137
           +GQ ++ GS+ VW  I P   G+G   + + F  + YY  ++AW  +YL+ SF   LPW+
Sbjct: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 138 SCPPDLNRTGFVE-----ECQGSSAVSY--------------FWYRQTLNITADINDSGS 178
           +C    N    VE     +C  +S  +               FW  + L ++  +   G+
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230

Query: 179 IQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLI 238
           + W + +CL A W +VY CV +G+++TGK++YFTA FPY+VL + L+RG+ LPGA  G+I
Sbjct: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290

Query: 239 YLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRM 298
           Y   P+   L +P+VW+DA TQIFFS ++  G   A  SYN   N+C KDA+++AL+N  
Sbjct: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSG 350

Query: 299 TSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWP 358
           TS +A   VFS+LGF A     H                                     
Sbjct: 351 TSFFAGFVVFSILGFMAAEQGVHI------------------------------------ 374

Query: 359 KRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTM 418
            +VA+                SGPGLAF+ +      MP AP+WA LFF ML  LGL + 
Sbjct: 375 SKVAE----------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQ 418

Query: 419 FGTVEAVITPLLDVGVLPR----WVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNF 474
           F  VE  IT LLD  +LP        +E    L C +CF+         G Y  ++FD +
Sbjct: 419 FVGVEGFITGLLD--LLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 476

Query: 475 AAS-PNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLL-LTIFV 532
           +AS   LL  AF E V V +VYG  RF DDIA M G RP P+ +  W   +PL+ + IF+
Sbjct: 477 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 536

Query: 533 AYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLT 592
             ++  +++PL Y   N  Y         +YP W  A     +L  +L VP+  L  LL 
Sbjct: 537 FNVV--YYEPLVY---NNTY---------VYPWWGEAMGWAFALSSMLCVPLHLLGCLL- 581

Query: 593 RRRRTWRDR 601
           R + T  +R
Sbjct: 582 RAKGTMAER 590


>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score =  382 bits (981), Expect = e-106
 Identities = 214/623 (34%), Positives = 322/623 (51%), Gaps = 91/623 (14%)

Query: 13  DLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIF 72
           D    R  W  K  +LLSC G+ VGLGN+WRFPY   T GGGAFL+PY + L   GIP+F
Sbjct: 32  DFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLF 91

Query: 73  HVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQH 132
            +EL++GQ    G + VW  ISP   G G   + +  L+++YYN I+A+VL+YL  S   
Sbjct: 92  FLELSLGQFSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTS 150

Query: 133 PLPWSSCPPDLNRTGFVEE---------------CQGSSAVSYFWYRQTLNITAD--IND 175
            LPW  C    N    +E                C  S +  Y W R  L+I     I  
Sbjct: 151 DLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEY-WSRYVLHIQGSQGIGS 209

Query: 176 SGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATK 235
            G I+W L +CL  +W +V++C+++G++++GKV+YFTA FPYL+L + L+RG+TLPGA K
Sbjct: 210 PGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWK 269

Query: 236 GLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALV 295
           G+ +  TP  H L + +VW++AA QIF+SL + FGG + FASYN+   +  +D  ++ L 
Sbjct: 270 GIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLG 329

Query: 296 NRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNA 355
           N +TS+ A  A+FSVLG+                +  +   P   +++            
Sbjct: 330 NAITSILAGFAIFSVLGY----------------MSQELGVPVDQVAK------------ 361

Query: 356 TWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGL 415
                                   +GPGLAFVV+ +    +P +P W+ LFF ML TLGL
Sbjct: 362 ------------------------AGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGL 397

Query: 416 STMFGTVEAVITPLLDVGVLPRWV-PKEAL-TGLVCLVCFLSATCFTLQSGNYWLEIFDN 473
            + F  +E ++T + D    P ++ PK+A+ +GL+C+  +L     T   G YWL + D+
Sbjct: 398 DSQFAFLETIVTAVTD--EFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDD 455

Query: 474 FAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVA 533
           ++AS  L+++     + V  VYG++RFC DI  M G +P  Y+R  W  +SP  L   + 
Sbjct: 456 YSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMV 515

Query: 534 YIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTR 593
           Y I+ + +P  Y ++              +P WA    +L+ LL  L +P   L  +L  
Sbjct: 516 YSIVKY-QPSEYGSYR-------------FPPWAELLGILMGLLSCLMIPAGMLVAVLRE 561

Query: 594 RRRTWR--DRDARPDTDMRPDTD 614
               W    + +RP  D  P  +
Sbjct: 562 EGSLWERLQQASRPAMDWGPSLE 584


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  373 bits (957), Expect = e-103
 Identities = 213/623 (34%), Positives = 320/623 (51%), Gaps = 111/623 (17%)

Query: 13  DLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIF 72
           D   +R  W  K+ YLLS  G+AVGLGN+WRFPYL  + GGGAFLIPY I L   G+P+F
Sbjct: 31  DENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLF 90

Query: 73  HVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQH 132
            +E ++GQ    G V VW  I P   GVG+  V +S  +++YYN I+A+ L+Y+  SFQ 
Sbjct: 91  FLECSLGQFASLGPVSVW-RILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQS 149

Query: 133 PLPWSSC----PPDLNRTGFVEECQ----------------------------------- 153
            LPW +C      + +R+  V  C                                    
Sbjct: 150 ELPWKNCSSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQP 209

Query: 154 GSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTA 213
           G      +W +  L  ++ +N++G I W+L +CL  +W +V   + +GI+++GKV+YFTA
Sbjct: 210 GQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTA 269

Query: 214 LFPYLVLTIFLIRGLTLPGATKGLIYLF--TPNMHILQNPRVWLDAATQIFFSLSLAFGG 271
           LFPY+VL I L+RG TL GA+KG+ Y      N   L+   VW DAATQIF+SLS+A+GG
Sbjct: 270 LFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGG 329

Query: 272 HIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLI 331
            +A +SYN  +N+C  DA+V+ L N +TS++A  A+FS+LG  A                
Sbjct: 330 LVALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMA---------------- 373

Query: 332 NDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTE 391
                               H++    K V+Q+               SG  LAF+ + E
Sbjct: 374 --------------------HISG---KEVSQV-------------VKSGFDLAFIAYPE 397

Query: 392 TDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPRWVPKEALTGLVCLV 451
               +PG P W++LFF ML TLGL + F ++E + T + D+        +  +T   CLV
Sbjct: 398 ALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLV 457

Query: 452 CFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRR 511
            FL       Q+G YW+ + D+F A   +L+ A LE+VG++++YG  RF +D   M G +
Sbjct: 458 LFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAK 517

Query: 512 PSPY---WRLTWRVVSPLLLTIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWAR 568
              +   WR  W V++P+LL      I +  W  +++    P Y   P      YP W  
Sbjct: 518 RWIFWLWWRACWFVITPILL------IAIFIWSLVQFH--RPNYGAIP------YPDWGV 563

Query: 569 AACVLLSLLPVLWVPVAALAQLL 591
           A    + +  ++W+P+ A+ +++
Sbjct: 564 ALGWCMIVFCIIWIPIMAIIKII 586


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  372 bits (954), Expect = e-103
 Identities = 219/596 (36%), Positives = 318/596 (53%), Gaps = 86/596 (14%)

Query: 17  ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVEL 76
           +R +W NK +++LS  G  +GLGN+WRFPYLC   GGGAF IPY I     GIP+F +E+
Sbjct: 35  DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEV 94

Query: 77  AIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPW 136
           A+GQ   +GSV  W  I P   G+GL  V +   +++YY  I+AW L+YL +SF   LPW
Sbjct: 95  ALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPW 154

Query: 137 SSCPPDLNR---TGFVEECQG---------SSAVSYFWYRQTLNITADINDSGSIQWWLL 184
           ++C    N    T F+              +S V  FW R+ L IT+ I+D GS++W L 
Sbjct: 155 TTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWELA 214

Query: 185 ICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPN 244
           +CL  +W + Y C+ +G+++TGKV+YFTA FPYL+L I LIRG+TLPGA +G+IY   P+
Sbjct: 215 LCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPD 274

Query: 245 MHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYAS 304
           +  L++P+VW+DA TQIFFS ++  G   A  SYN   N+C KD + +  +N  TS  A 
Sbjct: 275 LFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAG 334

Query: 305 IAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQL 364
             VFS+LGF +                      EQ +                       
Sbjct: 335 FVVFSILGFMS---------------------QEQGV----------------------- 350

Query: 365 PLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEA 424
           P+         + + SGPGLAF+ F +    MP + +W+ LFF ML  LGL + F  VE 
Sbjct: 351 PIS--------EVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVEC 402

Query: 425 VITPLLDVGVLPRWVPK----EALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASP-N 479
           ++T  +D  + PR + K    E L   + ++C+L       + G Y  ++FD +A+S   
Sbjct: 403 LVTASID--MFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGIC 460

Query: 480 LLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSP-LLLTIFVAYIILL 538
           LL L+  EVV + +VYG  RF D+I  M G RP P  +++W  ++P L L  F+    L 
Sbjct: 461 LLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFL--FSLS 518

Query: 539 FWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRR 594
            + PL+Y   N  Y         +YP W  +    L+L  ++ VP+  +  LL  R
Sbjct: 519 KYTPLKY---NNVY---------VYPPWGYSIGWFLALSSMVCVPLFVVITLLKTR 562


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  372 bits (954), Expect = e-103
 Identities = 219/596 (36%), Positives = 318/596 (53%), Gaps = 86/596 (14%)

Query: 17  ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVEL 76
           +R +W NK +++LS  G  +GLGN+WRFPYLC   GGGAF IPY I     GIP+F +E+
Sbjct: 35  DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEV 94

Query: 77  AIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPW 136
           A+GQ   +GSV  W  I P   G+GL  V +   +++YY  I+AW L+YL +SF   LPW
Sbjct: 95  ALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPW 154

Query: 137 SSCPPDLNR---TGFVEECQG---------SSAVSYFWYRQTLNITADINDSGSIQWWLL 184
           ++C    N    T F+              +S V  FW R+ L IT+ I+D GS++W L 
Sbjct: 155 TTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWELA 214

Query: 185 ICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPN 244
           +CL  +W + Y C+ +G+++TGKV+YFTA FPYL+L I LIRG+TLPGA +G+IY   P+
Sbjct: 215 LCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPD 274

Query: 245 MHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYAS 304
           +  L++P+VW+DA TQIFFS ++  G   A  SYN   N+C KD + +  +N  TS  A 
Sbjct: 275 LFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAG 334

Query: 305 IAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQL 364
             VFS+LGF +                      EQ +                       
Sbjct: 335 FVVFSILGFMS---------------------QEQGV----------------------- 350

Query: 365 PLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEA 424
           P+         + + SGPGLAF+ F +    MP + +W+ LFF ML  LGL + F  VE 
Sbjct: 351 PIS--------EVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVEC 402

Query: 425 VITPLLDVGVLPRWVPK----EALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASP-N 479
           ++T  +D  + PR + K    E L   + ++C+L       + G Y  ++FD +A+S   
Sbjct: 403 LVTASID--MFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGIC 460

Query: 480 LLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSP-LLLTIFVAYIILL 538
           LL L+  EVV + +VYG  RF D+I  M G RP P  +++W  ++P L L  F+    L 
Sbjct: 461 LLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFL--FSLS 518

Query: 539 FWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRR 594
            + PL+Y   N  Y         +YP W  +    L+L  ++ VP+  +  LL  R
Sbjct: 519 KYTPLKY---NNVY---------VYPPWGYSIGWFLALSSMVCVPLFVVITLLKTR 562


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  372 bits (954), Expect = e-103
 Identities = 219/596 (36%), Positives = 318/596 (53%), Gaps = 86/596 (14%)

Query: 17  ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVEL 76
           +R +W NK +++LS  G  +GLGN+WRFPYLC   GGGAF IPY I     GIP+F +E+
Sbjct: 35  DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEV 94

Query: 77  AIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPW 136
           A+GQ   +GSV  W  I P   G+GL  V +   +++YY  I+AW L+YL +SF   LPW
Sbjct: 95  ALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPW 154

Query: 137 SSCPPDLNR---TGFVEECQG---------SSAVSYFWYRQTLNITADINDSGSIQWWLL 184
           ++C    N    T F+              +S V  FW R+ L IT+ I+D GS++W L 
Sbjct: 155 TTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWELA 214

Query: 185 ICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPN 244
           +CL  +W + Y C+ +G+++TGKV+YFTA FPYL+L I LIRG+TLPGA +G+IY   P+
Sbjct: 215 LCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPD 274

Query: 245 MHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYAS 304
           +  L++P+VW+DA TQIFFS ++  G   A  SYN   N+C KD + +  +N  TS  A 
Sbjct: 275 LFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAG 334

Query: 305 IAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQL 364
             VFS+LGF +                      EQ +                       
Sbjct: 335 FVVFSILGFMS---------------------QEQGV----------------------- 350

Query: 365 PLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEA 424
           P+         + + SGPGLAF+ F +    MP + +W+ LFF ML  LGL + F  VE 
Sbjct: 351 PIS--------EVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVEC 402

Query: 425 VITPLLDVGVLPRWVPK----EALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASP-N 479
           ++T  +D  + PR + K    E L   + ++C+L       + G Y  ++FD +A+S   
Sbjct: 403 LVTASID--MFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGIC 460

Query: 480 LLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSP-LLLTIFVAYIILL 538
           LL L+  EVV + +VYG  RF D+I  M G RP P  +++W  ++P L L  F+    L 
Sbjct: 461 LLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFL--FSLS 518

Query: 539 FWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRR 594
            + PL+Y   N  Y         +YP W  +    L+L  ++ VP+  +  LL  R
Sbjct: 519 KYTPLKY---NNVY---------VYPPWGYSIGWFLALSSMVCVPLFVVITLLKTR 562


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score =  365 bits (936), Expect = e-101
 Identities = 210/602 (34%), Positives = 321/602 (53%), Gaps = 96/602 (15%)

Query: 17  ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVEL 76
           +R  W N+ +++L+  G+AVGLGN+WRFPYLC   GGGAF+ PY I L+F GIP+F +EL
Sbjct: 26  KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMEL 85

Query: 77  AIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPW 136
           + GQ   +G +GVW  ISP   GVG G + +S  I +YYN ++    +Y  +S  H LPW
Sbjct: 86  SFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPW 144

Query: 137 SSCPPDLNR---TGFVE-----------------------ECQGSSAVSYFWYRQTLNIT 170
           + C    N     G ++                         Q +S    +W    L ++
Sbjct: 145 AYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLS 204

Query: 171 ADINDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTL 230
            DI + G ++  LL CL  SW VV++C+IRG++++GKV+YFTA FPY+VLTI  +RG+TL
Sbjct: 205 DDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTL 264

Query: 231 PGATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAV 290
            GA  G++Y  TP    +   +VW DAA+QIF+SL  A+GG I  ASYN   N+C +D+V
Sbjct: 265 EGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSV 324

Query: 291 VIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVL 350
           +I++ N  TS+YA   +FS+LGF A          N L +       + S   D  P + 
Sbjct: 325 IISITNCATSVYAGFVIFSILGFMA----------NHLGV-------DVSRVADHGPGLA 367

Query: 351 MHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGML 410
                 +P+ +  LP+                                +P+W++LFF ML
Sbjct: 368 F---VAYPEALTLLPI--------------------------------SPLWSLLFFFML 392

Query: 411 FTLGLSTMFGTVEAVITPLLDVGVLPRWV--PKEALTGLVCLVCFLSATCFTLQSGNYWL 468
             LGL T F  +E ++T ++D  V   W+   K  +T  V +  FL     T Q+G YWL
Sbjct: 393 ILLGLGTQFCLLETLVTAIVD-EVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWL 451

Query: 469 EIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLL 528
            + DN+AAS +L++++ +  V ++Y+YG + +  DI  M G  P  ++++ WR VSP ++
Sbjct: 452 LLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAII 511

Query: 529 TIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALA 588
             F+    ++ ++P+ Y  +              YPGWA A   L++L  VL +P+ A+ 
Sbjct: 512 -FFILVFTVIQYQPITYNHYQ-------------YPGWAVAIGFLMALSSVLCIPLYAMF 557

Query: 589 QL 590
           +L
Sbjct: 558 RL 559


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  365 bits (936), Expect = e-101
 Identities = 210/602 (34%), Positives = 321/602 (53%), Gaps = 96/602 (15%)

Query: 17  ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVEL 76
           +R  W N+ +++L+  G+AVGLGN+WRFPYLC   GGGAF+ PY I L+F GIP+F +EL
Sbjct: 99  KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMEL 158

Query: 77  AIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPW 136
           + GQ   +G +GVW  ISP   GVG G + +S  I +YYN ++    +Y  +S  H LPW
Sbjct: 159 SFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPW 217

Query: 137 SSCPPDLNR---TGFVE-----------------------ECQGSSAVSYFWYRQTLNIT 170
           + C    N     G ++                         Q +S    +W    L ++
Sbjct: 218 AYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLS 277

Query: 171 ADINDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTL 230
            DI + G ++  LL CL  SW VV++C+IRG++++GKV+YFTA FPY+VLTI  +RG+TL
Sbjct: 278 DDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTL 337

Query: 231 PGATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAV 290
            GA  G++Y  TP    +   +VW DAA+QIF+SL  A+GG I  ASYN   N+C +D+V
Sbjct: 338 EGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSV 397

Query: 291 VIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVL 350
           +I++ N  TS+YA   +FS+LGF A          N L +       + S   D  P + 
Sbjct: 398 IISITNCATSVYAGFVIFSILGFMA----------NHLGV-------DVSRVADHGPGLA 440

Query: 351 MHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGML 410
                 +P+ +  LP+                                +P+W++LFF ML
Sbjct: 441 F---VAYPEALTLLPI--------------------------------SPLWSLLFFFML 465

Query: 411 FTLGLSTMFGTVEAVITPLLDVGVLPRWV--PKEALTGLVCLVCFLSATCFTLQSGNYWL 468
             LGL T F  +E ++T ++D  V   W+   K  +T  V +  FL     T Q+G YWL
Sbjct: 466 ILLGLGTQFCLLETLVTAIVD-EVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWL 524

Query: 469 EIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLL 528
            + DN+AAS +L++++ +  V ++Y+YG + +  DI  M G  P  ++++ WR VSP ++
Sbjct: 525 LLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAII 584

Query: 529 TIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALA 588
             F+    ++ ++P+ Y  +              YPGWA A   L++L  VL +P+ A+ 
Sbjct: 585 -FFILVFTVIQYQPITYNHYQ-------------YPGWAVAIGFLMALSSVLCIPLYAMF 630

Query: 589 QL 590
           +L
Sbjct: 631 RL 632


>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score =  365 bits (936), Expect = e-101
 Identities = 210/602 (34%), Positives = 321/602 (53%), Gaps = 96/602 (15%)

Query: 17  ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVEL 76
           +R  W N+ +++L+  G+AVGLGN+WRFPYLC   GGGAF+ PY I L+F GIP+F +EL
Sbjct: 45  KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMEL 104

Query: 77  AIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPW 136
           + GQ   +G +GVW  ISP   GVG G + +S  I +YYN ++    +Y  +S  H LPW
Sbjct: 105 SFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPW 163

Query: 137 SSCPPDLNR---TGFVE-----------------------ECQGSSAVSYFWYRQTLNIT 170
           + C    N     G ++                         Q +S    +W    L ++
Sbjct: 164 AYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLS 223

Query: 171 ADINDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTL 230
            DI + G ++  LL CL  SW VV++C+IRG++++GKV+YFTA FPY+VLTI  +RG+TL
Sbjct: 224 DDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTL 283

Query: 231 PGATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAV 290
            GA  G++Y  TP    +   +VW DAA+QIF+SL  A+GG I  ASYN   N+C +D+V
Sbjct: 284 EGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSV 343

Query: 291 VIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVL 350
           +I++ N  TS+YA   +FS+LGF A          N L +       + S   D  P + 
Sbjct: 344 IISITNCATSVYAGFVIFSILGFMA----------NHLGV-------DVSRVADHGPGLA 386

Query: 351 MHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGML 410
                 +P+ +  LP+                                +P+W++LFF ML
Sbjct: 387 F---VAYPEALTLLPI--------------------------------SPLWSLLFFFML 411

Query: 411 FTLGLSTMFGTVEAVITPLLDVGVLPRWV--PKEALTGLVCLVCFLSATCFTLQSGNYWL 468
             LGL T F  +E ++T ++D  V   W+   K  +T  V +  FL     T Q+G YWL
Sbjct: 412 ILLGLGTQFCLLETLVTAIVD-EVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWL 470

Query: 469 EIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLL 528
            + DN+AAS +L++++ +  V ++Y+YG + +  DI  M G  P  ++++ WR VSP ++
Sbjct: 471 LLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAII 530

Query: 529 TIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALA 588
             F+    ++ ++P+ Y  +              YPGWA A   L++L  VL +P+ A+ 
Sbjct: 531 -FFILVFTVIQYQPITYNHYQ-------------YPGWAVAIGFLMALSSVLCIPLYAMF 576

Query: 589 QL 590
           +L
Sbjct: 577 RL 578


>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score =  362 bits (929), Expect = e-100
 Identities = 219/628 (34%), Positives = 324/628 (51%), Gaps = 83/628 (13%)

Query: 17  ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVEL 76
           ER  W+NK +++LS  G  +GLGN+WRFPYLC   GGGAF IPY++ L   GIP+F +E 
Sbjct: 31  ERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLET 90

Query: 77  AIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPW 136
           A+GQ   +G V  W  I P   G+G     +  L+++YY  ++AW L+YL +SF   LPW
Sbjct: 91  ALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPW 150

Query: 137 SSCPPDLNRTGFVE--ECQGS---------SAVSYFWYRQTLNITADINDSGSIQWWLLI 185
             C  + N    +E  +  GS         S V  FW R+ L I+  I   G+++W L +
Sbjct: 151 GGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELAL 210

Query: 186 CLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNM 245
           CL  +W + Y C+ +G+++TGKV+YFTA FPYL+L + LIRG+TLPGA +G+ +   PN+
Sbjct: 211 CLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNL 270

Query: 246 HILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASI 305
             L +P+VW+DA TQIFFS ++  G   A  SYN   N+C +D + +  +N  TS  A  
Sbjct: 271 TRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGF 330

Query: 306 AVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLP 365
           A+FS+LGF +                      EQ +                       P
Sbjct: 331 AIFSILGFMS---------------------QEQGV-----------------------P 346

Query: 366 LKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAV 425
           +         + + SGPGLAF+ +    + +P +P+WA  FF M+  LGL + F  VE++
Sbjct: 347 IS--------EVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESL 398

Query: 426 ITPLLDV--GVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPN-LLM 482
           +T L+D+   V  +   +E L   V +V FL       + G Y  ++FD +AAS   LL 
Sbjct: 399 VTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLF 458

Query: 483 LAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFWKP 542
           +A  E + V +VYG KRF D+I  M G RP P  +  W  ++P + T    +  L+ + P
Sbjct: 459 VAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLF-SLIKYTP 517

Query: 543 LRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRRRRTWRDRD 602
           L Y   N KY          YP W  A   LL+L  ++ +P  +L +L T  +  +R+R 
Sbjct: 518 LTY---NKKY---------TYPWWGDALGWLLALSSMVCIPAWSLYRLGT-LKGPFRERI 564

Query: 603 AR---PDTDMRPDTDTRPDTDMRPDTDM 627
            +   P  D+       P     P T +
Sbjct: 565 RQLMCPAEDLPQRNPAGPSAPATPRTSL 592


>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score =  361 bits (926), Expect = 1e-99
 Identities = 218/609 (35%), Positives = 306/609 (50%), Gaps = 105/609 (17%)

Query: 18  RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELA 77
           R  W  +  +++SC GFAVGLGN+WRFPYLC   GGG FLIPYV+  +  GIPIF +E++
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 78  IGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWS 137
           +GQ ++ GS+ VW  I P   G+G   + + F  + YY  ++AW  +YL+ SF   LPW+
Sbjct: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 138 SCPPDLNRTGFVE-----ECQGSSAVSY--------------FWYRQTLNITADINDSGS 178
           +C    N    VE     +C  +S  +               FW  + L ++  +   G+
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230

Query: 179 IQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLI 238
           + W + +CL A W +VY CV +G+++TGK++YFTA FPY+VL + L+RG+ LPGA  G+I
Sbjct: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290

Query: 239 YLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRM 298
           Y   P+   L +P+VW+DA TQIFFS ++  G   A  SYN   N+C             
Sbjct: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNG---------- 340

Query: 299 TSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWP 358
           TS +A   VFS+LGF A     H                                     
Sbjct: 341 TSFFAGFVVFSILGFMAAEQGVHI------------------------------------ 364

Query: 359 KRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTM 418
            +VA+                SGPGLAF+ +      MP AP+WA LFF ML  LGL + 
Sbjct: 365 SKVAE----------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQ 408

Query: 419 FGTVEAVITPLLDVGVLPR----WVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNF 474
           F  VE  IT LLD  +LP        +E    L C +CF+         G Y  ++FD +
Sbjct: 409 FVGVEGFITGLLD--LLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 466

Query: 475 AAS-PNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLL-LTIFV 532
           +AS   LL  AF E V V +VYG  RF DDIA M G RP P+ +  W   +PL+ + IF+
Sbjct: 467 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 526

Query: 533 AYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLT 592
             ++  +++PL Y   N  Y         +YP W  A     +L  +L VP+  L  LL 
Sbjct: 527 FNVV--YYEPLVY---NNTY---------VYPWWGEAMGWAFALSSMLCVPLHLLGCLL- 571

Query: 593 RRRRTWRDR 601
           R + T  +R
Sbjct: 572 RAKGTMAER 580


>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score =  358 bits (919), Expect = 8e-99
 Identities = 195/547 (35%), Positives = 289/547 (52%), Gaps = 63/547 (11%)

Query: 17  ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVEL 76
           ER  W  K  +LLS  G+AV LGN+WRFPY+C   GGGAFL+PY I  +F GIP+F++EL
Sbjct: 78  ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137

Query: 77  AIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPW 136
           A+GQ  R G + +W  I P   G+G     ++F I+ YYNTI+AW L+YL++SF   LPW
Sbjct: 138 ALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPW 197

Query: 137 SSCPPDLNR---TGFVEE------CQGSSAVSYFWYRQTLNI--TADINDSGSIQWWLLI 185
           +SC    N    T +  E         +S    F+ R  L I  +  + D G I W L +
Sbjct: 198 TSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLAL 257

Query: 186 CLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNM 245
           C+   + V+Y  + +G++T+GKV++ TA FPY++L++ L+RG TLPGA +G+++   PN 
Sbjct: 258 CIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNW 317

Query: 246 HILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASI 305
             L    VW+DAA QIFFSL   FG  +AFASYN   N+C +DA+V ++VN MTS  +  
Sbjct: 318 QKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGF 377

Query: 306 AVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLP 365
            +F+VLG+ A    E                    +++D  P++L               
Sbjct: 378 VIFTVLGYMAEMRNEDV----------------SEVAKDAGPSLL--------------- 406

Query: 366 LKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAV 425
                               F+ + E   +MP +  +A++FF ML TLGL + F  +E V
Sbjct: 407 --------------------FITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGV 446

Query: 426 ITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAF 485
           IT +LD         +E     V + CF  +       G Y +++ + +A  P +L +A 
Sbjct: 447 ITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVAL 506

Query: 486 LEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFWKPLRY 545
           +E V V + YG+ +FC D+  M G  P  +WR+ W  +SPL L +F+    L+    LR 
Sbjct: 507 IEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFL-LFIICSFLMSPPQLRL 565

Query: 546 KAWNPKY 552
             +N  Y
Sbjct: 566 FQYNYPY 572


>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score =  354 bits (909), Expect = 1e-97
 Identities = 213/604 (35%), Positives = 316/604 (52%), Gaps = 89/604 (14%)

Query: 15  GDERPK--WDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIF 72
           GD +P+  W  K  +LLS  GFAV L N+WRFPYLC   GGGAFLIPY + L+  G+P+F
Sbjct: 51  GDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLF 110

Query: 73  HVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQH 132
           ++ELA+GQ  R+G+  VW  I P+  GVG   + ++  +  YYN I+AW L+YL +SF  
Sbjct: 111 YMELALGQYNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTL 169

Query: 133 PLPWSSC-----------PPDLNRTGFVEECQGS----SAVSYFWYRQTLNI--TADIND 175
            LPW+ C           P  LN +      + S    +  + F+ R  L++  ++ I+D
Sbjct: 170 NLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHD 229

Query: 176 SGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATK 235
            G  QW LL+CL     V+Y  + +G++T+GKV++ TA  PY VL + L+ G+TLPGA+ 
Sbjct: 230 IGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASN 289

Query: 236 GLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALV 295
           G+      + + L+   VW+DAATQIFFSL   FG  IAFASYN   N+C +DA++ + +
Sbjct: 290 GINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSI 349

Query: 296 NRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNA 355
           N +TS  +  A+FS+LG+ A   +EH +                                
Sbjct: 350 NCITSFVSGFAIFSILGYMA---HEHKV-------------------------------- 374

Query: 356 TWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGL 415
                            +  D +  G GL F+++ E    + G+  WA++FF ML  LGL
Sbjct: 375 -----------------NIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGL 417

Query: 416 STMFGTVEAVITPLL-DVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNF 474
            +  G +EAVIT L  D  VL R   ++  T  V    FL A     + G Y L + D F
Sbjct: 418 DSSMGGMEAVITGLADDFQVLKR--HRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTF 475

Query: 475 AASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAY 534
           AA  ++L    +E +GV + YG+ RF +DI  M G RP  YWRL W+ VSP  L +FV  
Sbjct: 476 AAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFL-LFVVV 534

Query: 535 IILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRR 594
           + ++ +KPL Y              + ++P WA      ++L  ++ VP+  + + L+ +
Sbjct: 535 VSIINFKPLTY-------------DDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQ 581

Query: 595 RRTW 598
              W
Sbjct: 582 GSLW 585


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  353 bits (906), Expect = 3e-97
 Identities = 205/601 (34%), Positives = 303/601 (50%), Gaps = 82/601 (13%)

Query: 7   PDPAACDLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVF 66
           P+  A     +R KW +K  ++LS  G  VGLGN+WRFPYLC   GGGAFLIPY I L  
Sbjct: 30  PEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFG 89

Query: 67  EGIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYL 126
            G+P+F +E+ IGQ   +G +  W  I P  SG+G   V +  L+++YY  I+AW  +YL
Sbjct: 90  SGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYL 149

Query: 127 LNSFQHPLPWSSCPPDLNRTGFVEECQG--------------SSAVSYFWYRQTLNITAD 172
             SFQ  LPW+ C    N    +E+                 +S V  FW R  L+++  
Sbjct: 150 FQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPG 209

Query: 173 INDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPG 232
           I+  GS++W L +CL   W V + C+ +G+ +TGKV+YFTA FP+ +L + L+RGLTLPG
Sbjct: 210 IDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPG 269

Query: 233 ATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVI 292
           A  G+ +   P++  L++P+VW+DA TQIFFS ++  G   +  SYN  + +  +D +++
Sbjct: 270 AGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLL 329

Query: 293 ALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMH 352
             +N  TS  +  A+FS+LGF A                      EQ +           
Sbjct: 330 GCLNSGTSFVSGFAIFSILGFMA---------------------QEQGV----------- 357

Query: 353 LNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFT 412
                               D  D + SGPGLAF+ + +    MP    W++LFF ML  
Sbjct: 358 --------------------DIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLL 397

Query: 413 LGLSTMFGTVEAVITPLLDV--GVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEI 470
           LGL + F  VE  IT L+D+    L +   +E     VC + +L       + G Y  ++
Sbjct: 398 LGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQL 457

Query: 471 FDNFAAS-PNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLT 529
           FD +AAS   LL +AF E   + ++YG     D I  M G RP P+ + +W V++P +L 
Sbjct: 458 FDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITP-VLC 516

Query: 530 IFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQ 589
           +      L+ + PL Y   N  Y         +YP WA      L+L  +L VP+  + +
Sbjct: 517 VGCFIFSLVKYVPLTY---NKTY---------VYPNWAIGLGWSLALSSMLCVPLVIVIR 564

Query: 590 L 590
           L
Sbjct: 565 L 565


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  353 bits (906), Expect = 3e-97
 Identities = 205/601 (34%), Positives = 303/601 (50%), Gaps = 82/601 (13%)

Query: 7   PDPAACDLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVF 66
           P+  A     +R KW +K  ++LS  G  VGLGN+WRFPYLC   GGGAFLIPY I L  
Sbjct: 30  PEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFG 89

Query: 67  EGIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYL 126
            G+P+F +E+ IGQ   +G +  W  I P  SG+G   V +  L+++YY  I+AW  +YL
Sbjct: 90  SGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYL 149

Query: 127 LNSFQHPLPWSSCPPDLNRTGFVEECQG--------------SSAVSYFWYRQTLNITAD 172
             SFQ  LPW+ C    N    +E+                 +S V  FW R  L+++  
Sbjct: 150 FQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPG 209

Query: 173 INDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPG 232
           I+  GS++W L +CL   W V + C+ +G+ +TGKV+YFTA FP+ +L + L+RGLTLPG
Sbjct: 210 IDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPG 269

Query: 233 ATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVI 292
           A  G+ +   P++  L++P+VW+DA TQIFFS ++  G   +  SYN  + +  +D +++
Sbjct: 270 AGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLL 329

Query: 293 ALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMH 352
             +N  TS  +  A+FS+LGF A                      EQ +           
Sbjct: 330 GCLNSGTSFVSGFAIFSILGFMA---------------------QEQGV----------- 357

Query: 353 LNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFT 412
                               D  D + SGPGLAF+ + +    MP    W++LFF ML  
Sbjct: 358 --------------------DIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLL 397

Query: 413 LGLSTMFGTVEAVITPLLDV--GVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEI 470
           LGL + F  VE  IT L+D+    L +   +E     VC + +L       + G Y  ++
Sbjct: 398 LGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQL 457

Query: 471 FDNFAAS-PNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLT 529
           FD +AAS   LL +AF E   + ++YG     D I  M G RP P+ + +W V++P +L 
Sbjct: 458 FDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITP-VLC 516

Query: 530 IFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQ 589
           +      L+ + PL Y   N  Y         +YP WA      L+L  +L VP+  + +
Sbjct: 517 VGCFIFSLVKYVPLTY---NKTY---------VYPNWAIGLGWSLALSSMLCVPLVIVIR 564

Query: 590 L 590
           L
Sbjct: 565 L 565


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  352 bits (904), Expect = 5e-97
 Identities = 203/587 (34%), Positives = 308/587 (52%), Gaps = 86/587 (14%)

Query: 17  ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVEL 76
           +R  W  K  +LLS  GFAV L N+WRFPYLC   GGGAFL+PY++ +V  G+P+F++EL
Sbjct: 59  DRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMEL 118

Query: 77  AIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPW 136
           A+GQ  R+G+ GVW  I P L GVG   + +S  +  +YN I+AW L YL +SF   LPW
Sbjct: 119 ALGQFNREGAAGVWK-ICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPW 177

Query: 137 SSCPPDLNR--------------TGFVEECQGSSAVSYFWYRQTLNI--TADINDSGSIQ 180
             C    N               +  + +  G++  + ++ R  L++  +  I+D G  +
Sbjct: 178 IHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPR 237

Query: 181 WWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYL 240
           W L  CL     ++Y  + +G++T+GKV++ TA  PY+VLT  L+RG+TLPGA  G+   
Sbjct: 238 WQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAY 297

Query: 241 FTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTS 300
            + + + L    VW+DAATQ+ FSL + FG  IAF+SYN   N+C +DA+V   +N +TS
Sbjct: 298 LSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTS 357

Query: 301 LYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKR 360
             +   VFS LG+ A                     P   +++D                
Sbjct: 358 FSSGFVVFSFLGYMA----------------QKHSVPIGDVAKD---------------- 385

Query: 361 VAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFG 420
                               GPGL F+++ E    +P +  WA++FF ML TLG+ +  G
Sbjct: 386 --------------------GPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMG 425

Query: 421 TVEAVITPLLD-VGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPN 479
            +E+VIT L+D   +L R   +E  T  + L  FL +       G Y   + D+FAA  +
Sbjct: 426 GMESVITGLIDEFQLLHR--HRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTS 483

Query: 480 LLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAYIILLF 539
           +L    +E +GV + YG+ +F DDI  MTG+RPS YWRL W++VSP  L +FV  + ++ 
Sbjct: 484 ILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFL-LFVVVVSIVT 542

Query: 540 WKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAA 586
           ++P  Y A+             ++P WA A   +++   +  VP+ A
Sbjct: 543 FRPPHYGAY-------------IFPDWANALGWVIATSSMAMVPIYA 576


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  340 bits (873), Expect = 2e-93
 Identities = 199/585 (34%), Positives = 306/585 (52%), Gaps = 83/585 (14%)

Query: 17  ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVEL 76
           ER  W+NK +++LS  G  +GLGN+WRFPYLC   GGGAFLIPYV+  +  GIP+F +E 
Sbjct: 49  ERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLET 108

Query: 77  AIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPW 136
           A+GQ   +G +  W  + P   G+G     +   +++YY  I+AW ++YL N F   LPW
Sbjct: 109 ALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPW 168

Query: 137 SSCPPDLNRTGFVEECQ-------------GSSAVSYFWYRQTLNITADINDSGSIQWWL 183
           ++C  + N    VE  +              +S V  FW  + L I+  I   G+++W L
Sbjct: 169 ATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWEL 228

Query: 184 LICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTP 243
            +CL A+W + Y C+ +G ++TGKV+Y TA FPY++L I LIRG+TLPGA++G+ +   P
Sbjct: 229 ALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYP 288

Query: 244 NMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYA 303
           ++  L +P+VW+DA TQIFFS ++  G   A  SYN+  N+C +D +++  +N  TS  A
Sbjct: 289 DLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVA 348

Query: 304 SIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQ 363
             A+FSVLGF A   YE                P   ++ +  P +       +PK V  
Sbjct: 349 GFAIFSVLGFMA---YEQ-------------GVPIAEVA-ESGPGLAF---IAYPKAVTM 388

Query: 364 LPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVE 423
           +PL                                +P+WA LFF ML  LGL + F  VE
Sbjct: 389 MPL--------------------------------SPLWATLFFMMLIFLGLDSQFVCVE 416

Query: 424 AVITPLLDV--GVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPN-L 480
           +++T ++D+   V  R   +E L   + ++ +        + G Y  ++FD++AAS   L
Sbjct: 417 SLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCL 476

Query: 481 LMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSP-LLLTIFVAYIILLF 539
           L +A  E + + +VYG  RF D+I  M G RP    +  W +++P +   IF+ ++I   
Sbjct: 477 LFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIK-- 534

Query: 540 WKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPV 584
           +KPL+Y   N  Y          YP W      L++L  +L +P+
Sbjct: 535 YKPLKY---NNIY---------TYPAWGYGIGWLMALSSMLCIPL 567


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  327 bits (838), Expect = 2e-89
 Identities = 190/582 (32%), Positives = 301/582 (51%), Gaps = 25/582 (4%)

Query: 18  RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELA 77
           RP W +K +Y+L+  GF++    +WRF YL    GG +F   Y+  L   G+P+  +E+A
Sbjct: 103 RPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMA 162

Query: 78  IGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWS 137
            GQ +R+G +GVW  I+P++ GVG     + F++ LY+N + +W+++Y+  SFQ P+PW 
Sbjct: 163 AGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWE 222

Query: 138 SCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMC 197
            CP  +N +GF  EC+ ++   YFWY+Q L  +  I D GS  + L++     W +V   
Sbjct: 223 KCPLTMNSSGFDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAF 282

Query: 198 VIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDA 257
           +I G+++TGKVIY   L P  ++  F IR L L GA  GL  L    +  + N  VW  A
Sbjct: 283 MINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLA 342

Query: 258 ATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATN 317
             Q+  +  +  G   + ASY    N+C  DA +++++N +T L  +   F VLGF AT 
Sbjct: 343 GGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATV 402

Query: 318 DYEHCLDRN---ILSLINDFDFPEQSISRDDYPAVLMHLNAT-----W----PKRVAQLP 365
               C +RN   +L LIN    P      D  P V +  N T     W    P+ +  + 
Sbjct: 403 ITHRCCERNAEILLKLINLGKLPP-----DAKPPVNLLYNPTSIYNAWLSGLPQHIKSMV 457

Query: 366 LK---ACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTV 422
           L+    C +E    K++ GP  AF+ F E    +P +  W+ +FF ML  +GLS+  G +
Sbjct: 458 LREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIM 517

Query: 423 EAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLM 482
           + +ITPL D     R   K  + G V L+ F+    FT  SG+Y++ +  ++     +++
Sbjct: 518 QGIITPLQDTFSFFRKHTKLLIVG-VFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIV 576

Query: 483 LAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSP-LLLTIFVAYIILLFWK 541
           +   E + V + YG +RF  D+  + G   SP +   W  + P +LL IFV  ++ L  K
Sbjct: 577 VVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMK 636

Query: 542 PLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVP 583
           P+ Y +W+        R    YP WA    + L  + +L +P
Sbjct: 637 PITYMSWDSSTSKEVLRP---YPPWALLLMITLFAIVILPIP 675


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score =  300 bits (768), Expect = 3e-81
 Identities = 188/545 (34%), Positives = 269/545 (49%), Gaps = 95/545 (17%)

Query: 82  LRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSCPP 141
           ++ GS+ VW  I P   G+G   + + F  + YY  ++AW  +YL+ SF   LPW++C  
Sbjct: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59

Query: 142 DLNRTGFVE-----ECQGSSAVSY--------------FWYRQTLNITADINDSGSIQWW 182
             N    VE     +C  +S  +               FW  + L ++  +   G++ W 
Sbjct: 60  TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119

Query: 183 LLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFT 242
           + +CL A W +VY CV +G+++TGK++YFTA FPY+VL + L+RG+ LPGA  G+IY   
Sbjct: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179

Query: 243 PNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLY 302
           P+   L +P+VW+DA TQIFFS ++  G   A  SYN   N+C KDA+++AL+N  TS +
Sbjct: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239

Query: 303 ASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVA 362
           A   VFS+LGF A     H                                      +VA
Sbjct: 240 AGFVVFSILGFMAAEQGVHI------------------------------------SKVA 263

Query: 363 QLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTV 422
           +                SGPGLAF+ +      MP AP+WA LFF ML  LGL + F  V
Sbjct: 264 E----------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGV 307

Query: 423 EAVITPLLDVGVLPR----WVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAAS- 477
           E  IT LLD  +LP        +E    L C +CF+         G Y  ++FD ++AS 
Sbjct: 308 EGFITGLLD--LLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG 365

Query: 478 PNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLL-LTIFVAYII 536
             LL  AF E V V +VYG  RF DDIA M G RP P+ +  W   +PL+ + IF+  ++
Sbjct: 366 TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV 425

Query: 537 LLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRRRR 596
             +++PL Y   N  Y         +YP W  A     +L  +L VP+  L  LL R + 
Sbjct: 426 --YYEPLVY---NNTY---------VYPWWGEAMGWAFALSSMLCVPLHLLGCLL-RAKG 470

Query: 597 TWRDR 601
           T  +R
Sbjct: 471 TMAER 475


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  242 bits (618), Expect = 7e-64
 Identities = 108/212 (50%), Positives = 156/212 (73%), Gaps = 5/212 (2%)

Query: 13  DLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIF 72
           ++ DERP W++K QY+L+  GF+VGLGN+WRFPYLCQ  GGGA+L+PY+I L+  GIP+F
Sbjct: 56  EVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLF 115

Query: 73  HVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQH 132
            +EL++GQR+R+GS+GVW  ISP L G+G     + + ++LYYN I+ W L+Y   SFQ 
Sbjct: 116 FLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQ 175

Query: 133 PLPWSSCPPDLNRT-GFVE-ECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAAS 190
           PLPW  CP   N +  FVE EC+ SSA +Y+WYR+ LNI++ I++SG + W + ICL A+
Sbjct: 176 PLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAA 235

Query: 191 WAVVYMCVIRGIETTGKVIYFTALFPYLVLTI 222
           W +V + +I+GI+++GKV   + L P+L+L I
Sbjct: 236 WVMVCLAMIKGIQSSGKV---SMLEPFLILLI 264


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score =  138 bits (347), Expect = 2e-32
 Identities = 64/145 (44%), Positives = 86/145 (59%)

Query: 7   PDPAACDLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVF 66
           P+  A     +R KW +K  ++LS  G  VGLGN+WRFPYLC   GGGAFLIPY I L  
Sbjct: 30  PEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFG 89

Query: 67  EGIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYL 126
            G+P+F +E+ IGQ   +G +  W  I P  SG+G   V +  L+++YY  I+AW  +YL
Sbjct: 90  SGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYL 149

Query: 127 LNSFQHPLPWSSCPPDLNRTGFVEE 151
             SFQ  LPW+ C    N    +E+
Sbjct: 150 FQSFQKELPWAHCNHSWNTPHCMED 174


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.141    0.471 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,283,048
Number of Sequences: 37866
Number of extensions: 1116579
Number of successful extensions: 3030
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2867
Number of HSP's gapped (non-prelim): 65
length of query: 628
length of database: 18,247,518
effective HSP length: 108
effective length of query: 520
effective length of database: 14,157,990
effective search space: 7362154800
effective search space used: 7362154800
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.