BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|193211480 superkiller viralicidic activity 2-like 2 [Homo sapiens] (1042 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|193211480 superkiller viralicidic activity 2-like 2 [Homo sap... 2076 0.0 gi|67782311 superkiller viralicidic activity 2-like homolog [Hom... 573 e-163 gi|130484567 HFM1 protein [Homo sapiens] 114 5e-25 gi|76880486 activating signal cointegrator 1 complex subunit 3 i... 111 4e-24 gi|139394648 DNA polymerase theta [Homo sapiens] 107 8e-23 gi|40217847 activating signal cointegrator 1 complex subunit 3-l... 96 1e-19 gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD prote... 92 3e-18 gi|110556640 DNA helicase HEL308 [Homo sapiens] 87 1e-16 gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Hom... 84 9e-16 gi|222831595 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 [Homo sap... 80 8e-15 gi|14591902 RecQ protein-like [Homo sapiens] 41 0.005 gi|14591904 RecQ protein-like [Homo sapiens] 41 0.005 gi|51094101 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 2 ... 39 0.020 gi|164419743 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 1... 39 0.020 gi|31543667 suppressor of var1, 3-like 1 [Homo sapiens] 39 0.026 gi|13129006 nucleolar protein GU2 [Homo sapiens] 35 0.28 gi|167830436 DEAH (Asp-Glu-Ala-His) box polypeptide 36 isoform 2... 35 0.37 gi|167830433 DEAH (Asp-Glu-Ala-His) box polypeptide 36 isoform 1... 35 0.37 gi|122937345 myosin VB [Homo sapiens] 35 0.48 gi|116812616 RecQ protein-like 4 [Homo sapiens] 34 0.63 gi|110735439 Werner syndrome protein [Homo sapiens] 34 0.82 gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent... 34 0.82 gi|224593278 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Homo sap... 33 1.4 gi|215982794 myosin VA isoform 2 [Homo sapiens] 33 1.8 gi|215982791 myosin VA isoform 1 [Homo sapiens] 33 1.8 gi|42415492 chromosome 14 open reading frame 106 [Homo sapiens] 32 3.1 gi|14550416 Fc receptor-like 4 precursor [Homo sapiens] 32 4.1 gi|13376617 prostaglandin E synthase 2 [Homo sapiens] 31 5.3 gi|51599156 chromodomain helicase DNA binding protein 4 [Homo sa... 31 5.3 gi|153945715 myosin VC [Homo sapiens] 31 5.3 >gi|193211480 superkiller viralicidic activity 2-like 2 [Homo sapiens] Length = 1042 Score = 2076 bits (5378), Expect = 0.0 Identities = 1042/1042 (100%), Positives = 1042/1042 (100%) Query: 1 MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNG 60 MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNG Sbjct: 1 MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNG 60 Query: 61 KNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEE 120 KNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEE Sbjct: 61 KNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEE 120 Query: 121 DYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALR 180 DYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALR Sbjct: 121 DYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALR 180 Query: 181 EKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGS 240 EKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGS Sbjct: 181 EKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGS 240 Query: 241 EVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLH 300 EVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLH Sbjct: 241 EVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLH 300 Query: 301 KQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGD 360 KQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGD Sbjct: 301 KQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGD 360 Query: 361 QKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMV 420 QKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMV Sbjct: 361 QKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMV 420 Query: 421 EEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALF 480 EEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALF Sbjct: 421 EEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALF 480 Query: 481 ATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVD 540 ATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVD Sbjct: 481 ATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVD 540 Query: 541 EKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPG 600 EKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPG Sbjct: 541 EKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPG 600 Query: 601 VVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLV 660 VVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLV Sbjct: 601 VVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLV 660 Query: 661 KVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKP 720 KVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKP Sbjct: 661 KVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKP 720 Query: 721 DEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPI 780 DEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPI Sbjct: 721 DEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPI 780 Query: 781 DDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELK 840 DDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELK Sbjct: 781 DDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELK 840 Query: 841 KARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDL 900 KARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDL Sbjct: 841 KARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDL 900 Query: 901 SAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLS 960 SAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLS Sbjct: 901 SAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLS 960 Query: 961 SFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELE 1020 SFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELE Sbjct: 961 SFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELE 1020 Query: 1021 NKFAEGITKIKRDIVFAASLYL 1042 NKFAEGITKIKRDIVFAASLYL Sbjct: 1021 NKFAEGITKIKRDIVFAASLYL 1042 >gi|67782311 superkiller viralicidic activity 2-like homolog [Homo sapiens] Length = 1246 Score = 573 bits (1478), Expect = e-163 Identities = 361/1004 (35%), Positives = 542/1004 (53%), Gaps = 68/1004 (6%) Query: 91 SLADLMPRVKVQSVETVEG----CTHEVALPAEE-----DYLPLKPRVGKAAKEYPFILD 141 SL DL+ + +V T E + A+P + D+ L P+ A ++ F D Sbjct: 256 SLEDLVLKEASTAVSTPEAPEPPSQEQWAIPVDATSPVGDFYRLIPQ---PAFQWAFEPD 312 Query: 142 AFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYRE 201 FQ++AI ++ + SV V+AHTSAGKTV AEYAIALA + R I+TSPIKALSNQK+R+ Sbjct: 313 VFQKQAILHLERHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRD 372 Query: 202 MYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSE 261 F DVGL+TGDV ++P ASCL+MTTEILRSMLY GS+V+R++ WVIFDE+HY+ D E Sbjct: 373 FRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDVE 432 Query: 262 RGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIF 321 RGVVWEE +I+LPD+V + LSAT+PNA +FA+WI L ++ +VI T RP PL+HY+F Sbjct: 433 RGVVWEEVLIMLPDHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVTRPVPLEHYLF 492 Query: 322 PAGGD----GLHLVVDENGDFREDNFNTAMQVLRDA----GDLAKGDQKGRKGGTKGPSN 373 L L++D G F + A++ ++ Q +GG Sbjct: 493 TGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRG 552 Query: 374 VF-KIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAIDCLS 432 V+ ++ + R PV++F+FS+ C+ A +T LD T EK + + L Sbjct: 553 VYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLR 612 Query: 433 DEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMP 492 D++LPQV H+ LL RG+G+HH G+LPILKE +E+LFS GL+K LFATETFAMG+NMP Sbjct: 613 GSDRQLPQVLHMSELLNRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMP 672 Query: 493 ARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIG-KQL 551 ARTV+F + RK DG FR + GEY+QM+GRAGRRG+D G VIL+ ++ ++ Sbjct: 673 ARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRM 732 Query: 552 LKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQ 611 + G L S F LTY M+LNLLRV+ + E M+++SF +F + + + ++ Sbjct: 733 MMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALAELTKR 792 Query: 612 YNKIVIPNEESVVI----YYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGD 667 + P+ ++ YY ++L + I+ I + L L GR+V VKN+ Sbjct: 793 LGALEEPDMTGQLVDLPEYYSWGEELTETQHMIQRRIMESVNGLKSLSAGRVVVVKNQEH 852 Query: 668 DFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAK-------- 719 GV++ S S + V L+ C K ++ A+ Sbjct: 853 HNALGVILQVSSNSTSR----------VFTTLVLCDKPLSQDPQDRGPATAEVPYPDDLV 902 Query: 720 ------PDEKGEMQVVPVLVHLLSAISS--VRLYIPKDLRPVDNRQ-----------SVL 760 P+ + VV + ++AI++ +R+ K L RQ +V Sbjct: 903 GFKLFLPEGPCDHTVVKLQPGDMAAITTKVLRVNGEKILEDFSKRQQPKFKKDPPLAAVT 962 Query: 761 KSIQE---VQKRFPDGIPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLET 817 ++QE + + P G P LDP++D+ ++D + + + E + + P Sbjct: 963 TAVQELLRLAQAHPAGPPTLDPVNDLQLKDMSVVEGGLRARKLEELIQGAQCVHSPRFPA 1022 Query: 818 VYTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVA 877 Y ++ QI +++ R L +++L + E R VLR LG+ + +++ GRVA Sbjct: 1023 QYLKLRERMQIQKEMERL-RFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVA 1081 Query: 878 CEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQE 937 C +SS ELLLTE+MF+ + L E+ ALLS V Q +L L + +++ Sbjct: 1082 CAMSS-HELLLTELMFDNALSTLRPEEIAALLSGLVCQSPGDAGDQLPNTLKQGIERVRA 1140 Query: 938 CAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCM 997 AKRI +V L E ++ L++VVY WA G F+ + ++ EG ++RC+ Sbjct: 1141 VAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCI 1200 Query: 998 RRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRDIVFAASLY 1041 +RL E+ R + AA+ +G L K T ++RDIVFAASLY Sbjct: 1201 QRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLY 1244 >gi|130484567 HFM1 protein [Homo sapiens] Length = 1435 Score = 114 bits (285), Expect = 5e-25 Identities = 105/442 (23%), Positives = 188/442 (42%), Gaps = 85/442 (19%) Query: 134 KEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQ------RVIF 187 KE+P+ + + +++ ++ A T +GKTV E AI L E ++++ Sbjct: 276 KEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVY 335 Query: 188 TSPIKALSNQKYREMYEEFQDVGL----MTGDVTINPT-----ASCLVMTTEILRSML-- 236 +PIKAL +Q++ + E+F +GL +TGD ++ A ++ T E SM Sbjct: 336 MAPIKALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRK 395 Query: 237 YRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPD---------------NVHYVF 281 +R + +++ V + DE+H ++D RG E + + + +V Sbjct: 396 WRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVA 455 Query: 282 LSATIPNARQFAEWICHLHKQP-CHVIYTDYRPTPLQHYI--FPAGGDGLHLVVDENGDF 338 +SATIPNA AEW+ + C + +RP LQ + FP + D ++ Sbjct: 456 VSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNY 515 Query: 339 REDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKD 398 + + +++M ++ +P ++F ++K Sbjct: 516 K----------------------------------IASVIQMYSDQ--KPTLVFCATRKG 539 Query: 399 CEAYALQMTK--LDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHH 456 + A + K T E+K+ +++ S D KL + LK G HH Sbjct: 540 VQQAASVLVKDAKFIMTVEQKQRLQKY------AYSVRDSKLRDI------LKDGAAYHH 587 Query: 457 GGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGE 516 G+ ++ +E F+ G + LF T T AMG+N+PA V+ + + G F S + Sbjct: 588 AGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEYSETD 647 Query: 517 YIQMSGRAGRRGMDDRGIVILM 538 +QM GRAGR D ++M Sbjct: 648 ILQMIGRAGRPQFDTTATAVIM 669 >gi|76880486 activating signal cointegrator 1 complex subunit 3 isoform a [Homo sapiens] Length = 2202 Score = 111 bits (277), Expect = 4e-24 Identities = 118/417 (28%), Positives = 186/417 (44%), Gaps = 84/417 (20%) Query: 156 SVLVSAHTSAGKTVCAEYAIALALRE--KQRVIFTSPIKALSNQKYREMYEEFQD----- 208 +VL+ A T +GKTV AE AI + + ++ +P+KAL ++ + ++ Sbjct: 1344 NVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKK 1403 Query: 209 VGLMTGDVTIN----PTASCLVMTTE----ILRSMLYRGSEVMREVAWVIFDEIHYMRDS 260 V +TGDVT + A +V T E + RS ++ +++V +I DEIH + + Sbjct: 1404 VIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRS--WQNRNYVQQVTILIIDEIHLLGE- 1460 Query: 261 ERGVVWEETIILLPDN---------VHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDY 311 ERG V E +I+ N V V LS + NAR A+W+ ++ + Sbjct: 1461 ERGPVLE--VIVSRTNFISSHTEKPVRIVGLSTALANARDLADWL-NIKQMGLFNFRPSV 1517 Query: 312 RPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNT-AMQVLRDAGDLAKGDQKGRKGGTKG 370 RP PL+ +I G G H R + N A Q +R + Sbjct: 1518 RPVPLEVHI--QGFPGQHYCP------RMASMNKPAFQAIR----------------SHS 1553 Query: 371 PSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKK----MVEEVFSN 426 P+ +PV+IF S++ AL++ T+E+ K M E N Sbjct: 1554 PA--------------KPVLIFVSSRRQTRLTALELIAF-LATEEDPKQWLNMDEREMEN 1598 Query: 427 AIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFA 486 I + D + KL L GIG+HH GL ++T+E LF ++ L AT T A Sbjct: 1599 IIATVRDSNLKLT--------LAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLA 1650 Query: 487 MGINMPARTVLFTNARKFDGKDFRWIS--SGEYIQMSGRAGRRGMDDRGIVILMVDE 541 G+N PA V+ +DGK R++ + +QM GRAGR DD+G +++V + Sbjct: 1651 WGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHD 1707 Score = 77.0 bits (188), Expect = 8e-14 Identities = 105/457 (22%), Positives = 185/457 (40%), Gaps = 85/457 (18%) Query: 152 DNNQSVLVSAHTSAGKTVCAEYAIALALRE----------KQRVIFTSPIKALSNQKYRE 201 + N+++L+ A T AGKT A + +R+ + ++++ +P+KAL+ + Sbjct: 490 NTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDY 549 Query: 202 MYEEFQDVGL----MTGDVTINPTASCLVMTTEILRSMLYRGSEVMRE----------VA 247 + +G+ +TGD+ ++ + ++ T++L + + V R+ V Sbjct: 550 FSRRLEPLGIIVKELTGDMQLSKSE---ILRTQMLVTTPEKWDVVTRKSVGDVALSQIVR 606 Query: 248 WVIFDEIHYMRDSERGVVWEETIILL-------PDNVHYVFLSATIPNARQFAEWICHLH 300 +I DE+H + + +RG V E + + + LSAT+PN A + LH Sbjct: 607 LLILDEVHLLHE-DRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATF---LH 662 Query: 301 KQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGD 360 P YI DG V F MQ L + ++ Sbjct: 663 VNP---------------YIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCY-- 705 Query: 361 QKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMV 420 NV K VK + V++F ++ A+ + + N Sbjct: 706 -----------ENVLKQVKAGHQ-----VMVFVHARNATVRTAMSLIERAKNCGHIPFFF 749 Query: 421 EEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALF 480 + + L+++ + + + V L G IHH G+L + +E LFS G IK L Sbjct: 750 PTQGHDYV--LAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLV 807 Query: 481 ATETFAMGINMPARTVLFTNARKFDGKDFRWISSG--EYIQMSGRAGRRGMDDRGI-VIL 537 T T A G+N+PA V+ + + K ++ G + +Q+ GRAGR D G +I+ Sbjct: 808 CTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIII 867 Query: 538 MVDEKMS---------PTIGKQLLKGSADPLNSAFHL 565 +K+S I Q L+ AD LN+ L Sbjct: 868 TTHDKLSHYLTLLTQRNPIESQFLESLADNLNAEIAL 904 >gi|139394648 DNA polymerase theta [Homo sapiens] Length = 2590 Score = 107 bits (266), Expect = 8e-23 Identities = 121/458 (26%), Positives = 204/458 (44%), Gaps = 100/458 (21%) Query: 155 QSVLVSAHTSAGKTVCAEYAIALALRE-KQRVIFTSPIKALSNQKYREMYEEFQDVGLMT 213 ++++ SA TSAGKT+ AE I + E +++ +F P +++ +K + FQ+VG+ Sbjct: 109 KNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKV 168 Query: 214 ----GDVTINPTASCL---VMTTEILRSMLYRGSEV--MREVAWVIFDEIHYMRDSERGV 264 G + + S L V T E ++ R E M + V+ DE+H + DS RG Sbjct: 169 DGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGY 228 Query: 265 VWE------------------ETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHV 306 + E + L + V V +SAT+PN A W+ + Sbjct: 229 LLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWL------NAEL 282 Query: 307 IYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDL--AKGDQKGR 364 +TD+RP PL E+ ++++M+++R+ + KGD+ Sbjct: 283 YHTDFRPVPLL----------------ESVKVGNSIYDSSMKLVREFEPMLQVKGDED-- 324 Query: 365 KGGTKGPSNVFKIVKMIMER--NFQPVIIFSFSKKDCEAYALQMTKLDFNTD-------- 414 +V + E + V++F SKK CE A + + +N Sbjct: 325 -----------HVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVK 373 Query: 415 ---------EEKKMVEEVFSNAIDCLSDEDKKLPQ-VEHVLP-LLKRGIGIHHGGLLPIL 463 E+K+++E + D+ ++LP ++ VL + G+ HH GL Sbjct: 374 PSECPPVILEQKELLE---------VMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEE 424 Query: 464 KETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGR 523 ++ IE F +GLI+ L AT T + G+N+PAR V+ F G+ ++ Y QM GR Sbjct: 425 RDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVII-RTPIFGGRPLDILT---YKQMVGR 480 Query: 524 AGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNS 561 AGR+G+D G IL + + + G LL+GS P+ S Sbjct: 481 AGRKGVDTVGESIL-ICKNSEKSKGIALLQGSLKPVRS 517 >gi|40217847 activating signal cointegrator 1 complex subunit 3-like 1 [Homo sapiens] Length = 2136 Score = 96.3 bits (238), Expect = 1e-19 Identities = 112/461 (24%), Positives = 193/461 (41%), Gaps = 78/461 (16%) Query: 135 EYPFILDAFQREAIQCVDNNQ-SVLVSAHTSAGKTVCAEYAIALALREKQ--RVIFTSPI 191 ++PF + Q + V N+ +V V A T +GKT+CAE+AI L + R ++ +P+ Sbjct: 1324 KFPFF-NPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYITPM 1382 Query: 192 KALSNQKYREMYEEFQD-----VGLMTG----DVTINPTASCLVMTTE--ILRSMLYRGS 240 +AL+ Q Y + YE+FQD V L+TG D+ + + ++ T E + S ++ Sbjct: 1383 EALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQR 1442 Query: 241 EVMREVAWVIFDEIHYMRDSERGVVWEETI-------ILLPDNVHYVFLSATIPNARQFA 293 + ++ + + DE+H + E G V E + + V LS+++ NA+ A Sbjct: 1443 KNVQNINLFVVDEVHLI-GGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVA 1501 Query: 294 EWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDA 353 W+ + + RP PL+ +I G ++ +T ++L A Sbjct: 1502 HWL-GCSATSTFNFHPNVRPVPLELHI-----QGFNI------------SHTQTRLLSMA 1543 Query: 354 GDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQM---TKLD 410 + K P +PVI+F S+K A+ + D Sbjct: 1544 KPVYHAITK------HSPK--------------KPVIVFVPSRKQTRLTAIDILTTCAAD 1583 Query: 411 FNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEIL 470 E+ ++ LSD K L G+G H GL P+ + +E L Sbjct: 1584 IQRQRFLHCTEKDLIPYLEKLSDSTLK--------ETLLNGVGYLHEGLSPMERRLVEQL 1635 Query: 471 FSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEY--IQMSGRAGRRG 528 FS G I+ + A+ + G+N+ A V+ + + ++GK ++ Y +QM G A R Sbjct: 1636 FSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYPIYDVLQMVGHANRPL 1695 Query: 529 MDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNM 569 DD G ++M K L +PL HL + M Sbjct: 1696 QDDEGRCVIMCQGSKKDFFKKFLY----EPLPVESHLDHCM 1732 Score = 87.0 bits (214), Expect = 8e-17 Identities = 105/458 (22%), Positives = 191/458 (41%), Gaps = 81/458 (17%) Query: 118 AEEDYLPLK--PRVGKAAKEYPFILDAFQREAIQC-VDNNQSVLVSAHTSAGKTVCAEYA 174 +EE LP++ P+ +A E L+ Q + + ++ ++++L+ A T AGKT A Sbjct: 457 SEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKT---NVA 513 Query: 175 IALALRE--------------KQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTIN- 219 + LRE ++I+ +P+++L + + G+ ++T + Sbjct: 514 LMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDH 573 Query: 220 -------PTASCLVMTTEILRSMLYRGSE--VMREVAWVIFDEIHYMRDSERGVVWE--- 267 +V T E + +G E + V +I DEIH + D +RG V E Sbjct: 574 QLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDEIHLLHD-DRGPVLEALV 632 Query: 268 ----ETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPA 323 I + ++V + LSAT+PN A ++ + +RP PL+ Sbjct: 633 ARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQ----- 687 Query: 324 GGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIME 383 ++ + E + Q++ + + + IME Sbjct: 688 ----TYVGITEKKAIKR------FQIMNEI-----------------------VYEKIME 714 Query: 384 R-NFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVE 442 V++F S+K+ A + + D + E S + + L E ++ +E Sbjct: 715 HAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREG-SASTEVLRTEAEQCKNLE 773 Query: 443 HVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNAR 502 + LL G IHH G+ + + +E LF++ I+ L +T T A G+N+PA TV+ + Sbjct: 774 -LKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQ 832 Query: 503 KFDGKDFRWISSG--EYIQMSGRAGRRGMDDRGIVILM 538 + + RW G + +QM GRAGR D +G IL+ Sbjct: 833 VYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILI 870 >gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD protein, partial [Homo sapiens] Length = 1700 Score = 91.7 bits (226), Expect = 3e-18 Identities = 110/461 (23%), Positives = 190/461 (41%), Gaps = 78/461 (16%) Query: 135 EYPFILDAFQREAIQCVDNNQ-SVLVSAHTSAGKTVCAEYAIALALREKQ--RVIFTSPI 191 ++PF + Q + V N+ +V V A T +GKT+CAE+AI L + R ++ +P+ Sbjct: 888 KFPFF-NPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPM 946 Query: 192 KALSNQKYREMYEEFQD-----VGLMTG----DVTINPTASCLVMTTE--ILRSMLYRGS 240 + Q Y + YE+FQD V L+TG D+ + + ++ T E + S ++ Sbjct: 947 RLWQEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQR 1006 Query: 241 EVMREVAWVIFDEIHYMRDSERGVVWEETI-------ILLPDNVHYVFLSATIPNARQFA 293 + ++ + + DE+H + E G V E + + V LS+++ NA+ A Sbjct: 1007 KNVQNINLFVVDEVHLI-GGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVA 1065 Query: 294 EWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDA 353 W+ + + RP PL+ +I G ++ +T ++L A Sbjct: 1066 HWL-GCSATSTFNFHPNVRPVPLELHI-----QGFNI------------SHTQTRLLSMA 1107 Query: 354 GDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQM---TKLD 410 VF + + +PVI+F S+K A+ + D Sbjct: 1108 ------------------KPVFHAITKHSPK--KPVIVFVPSRKQTRLTAIDILTTCAAD 1147 Query: 411 FNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEIL 470 E+ ++ LSD K L G+G H GL P+ + +E L Sbjct: 1148 IQRQRFLHCTEKDLIPYLEKLSDSTLK--------ETLLNGVGYLHEGLSPMERRLVEQL 1199 Query: 471 FSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEY--IQMSGRAGRRG 528 FS G I+ + A+ + G+N+ A V+ + ++GK ++ Y +QM G A R Sbjct: 1200 FSSGAIQVVVASRSLCWGMNVAAHLVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANRPL 1259 Query: 529 MDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNM 569 DD G ++M K L +PL HL + M Sbjct: 1260 QDDEGRCVIMCQGSKKDFFKKFLY----EPLPVESHLDHCM 1296 Score = 86.3 bits (212), Expect = 1e-16 Identities = 104/458 (22%), Positives = 190/458 (41%), Gaps = 81/458 (17%) Query: 118 AEEDYLPLK--PRVGKAAKEYPFILDAFQREAIQC-VDNNQSVLVSAHTSAGKTVCAEYA 174 +EE LP++ P+ +A E L+ Q + + ++ ++++L+ A T AGKT A Sbjct: 21 SEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKT---NVA 77 Query: 175 IALALRE--------------KQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTIN- 219 + LRE ++I+ +P+++L + + G+ ++T + Sbjct: 78 LMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDH 137 Query: 220 -------PTASCLVMTTEILRSMLYRGSE--VMREVAWVIFDEIHYMRDSERGVVWE--- 267 +V T E + +G E + V ++ DEIH + D +RG V E Sbjct: 138 QLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDEIHLLHD-DRGPVLEALV 196 Query: 268 ----ETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPA 323 I + ++V + LSAT+PN A ++ + +RP PL+ Sbjct: 197 ARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQ----- 251 Query: 324 GGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIME 383 ++ + E + Q++ + + + IME Sbjct: 252 ----TYVGITEKKAIKR------FQIMNEI-----------------------VYEKIME 278 Query: 384 R-NFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVE 442 V++F S+K+ A + + D + E S + + L E ++ +E Sbjct: 279 HAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREG-SASTEVLRTEAEQCKNLE 337 Query: 443 HVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNAR 502 + LL G IHH G+ + + +E LF + I+ L +T T A G+N+PA TV+ + Sbjct: 338 -LKDLLPYGFAIHHAGMTRVDRTLVEDLFGDKHIQVLVSTATLAWGVNLPAHTVIIKGTQ 396 Query: 503 KFDGKDFRWISSG--EYIQMSGRAGRRGMDDRGIVILM 538 + + RW G + +QM GRAGR D +G IL+ Sbjct: 397 VYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILI 434 >gi|110556640 DNA helicase HEL308 [Homo sapiens] Length = 1101 Score = 86.7 bits (213), Expect = 1e-16 Identities = 127/575 (22%), Positives = 241/575 (41%), Gaps = 107/575 (18%) Query: 24 KKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNGKNKRDVDFEGTDEPIFGKKPRIE 83 ++ ++ D+ K S K L++ T N K PIF + +++ Sbjct: 241 EQPQQNDESSSKVRTSSDMNRRKSIKDHLKNAMTGNAK---------AQTPIFSRSKQLK 291 Query: 84 ESI-TEDLSLADLMPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDA 142 +++ +E++++A +TVE ++++ + L +V ++ I Sbjct: 292 DTLLSEEINVAK----------KTVESSSNDLG-----PFYSLPSKVRDLYAQFKGIEKL 336 Query: 143 FQRE----AIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALRE----KQRVIFTSPIKAL 194 ++ + + V ++++ S TS GKT+ AE L L+E ++ V+ P A+ Sbjct: 337 YEWQHTCLTLNSVQERKNLIYSLPTSGGKTLVAEI---LMLQELLCCRKDVLMILPYVAI 393 Query: 195 SNQKYREMYEEFQDVGLMTGDVT-----INPTA-----SCLVMTTEILRSMLYRGSEVMR 244 +K + ++G + PT S + T E S++ E R Sbjct: 394 VQEKISGLSSFGIELGFFVEEYAGSKGRFPPTKRREKKSLYIATIEKGHSLVNSLIETGR 453 Query: 245 --EVAWVIFDEIHYMRDSERGVVWEET---IILLPDNVHYVFLSATIPNARQFAEWICHL 299 + V+ DE+H + + RG E T I+ + +SAT+ N +++ Sbjct: 454 IDSLGLVVVDELHMIGEGSRGATLEMTLAKILYTSKTTQIIGMSATLNNVEDLQKFL--- 510 Query: 300 HKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVL--RDAGDLA 357 + +RP L+ Y+ D ++ V D + +N T ++L + + L Sbjct: 511 ---QAEYYTSQFRPVELKEYL--KINDTIYEV-----DSKAENGMTFSRLLNYKYSDTLK 560 Query: 358 KGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKL---DFNTD 414 K D P ++ +V ++ ++F SKK+CE A + K ++ Sbjct: 561 KMD----------PDHLVALVTEVIPN--YSCLVFCPSKKNCENVAEMICKFLSKEYLKH 608 Query: 415 EEKKMVEEVFSNAIDCLSDEDKKLPQVEH--VLPLLKR----GIGIHHGGLLPILKETIE 468 +EK+ E + K L + + + P+LKR G+ HH GL ++ +E Sbjct: 609 KEKEKCEVI------------KNLKNIGNGNLCPVLKRTIPFGVAYHHSGLTSDERKLLE 656 Query: 469 ILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRG 528 +S G++ T T A G+N+PAR V+ + K+F + +Y QM GRAGR G Sbjct: 657 EAYSTGVLCLFTCTSTLAAGVNLPARRVIL--RAPYVAKEF--LKRNQYKQMIGRAGRAG 712 Query: 529 MDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAF 563 +D G IL++ EK +Q+L+ PL + + Sbjct: 713 IDTIGESILILQEKDK----QQVLELITKPLENCY 743 >gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Homo sapiens] Length = 1706 Score = 83.6 bits (205), Expect = 9e-16 Identities = 54/128 (42%), Positives = 74/128 (57%), Gaps = 10/128 (7%) Query: 447 LLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDG 506 L +RGIG HH + KE +EILF +GLI+ + ATET A+GI+MP ++V+F Sbjct: 1240 LAQRGIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALGIHMPCKSVVF-------A 1292 Query: 507 KDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLT 566 +D ++ + Y QMSGRAGRRG D G V + P I K+LL S L F L+ Sbjct: 1293 QDSVYLDALNYRQMSGRAGRRGQDLLGNVYFF--DIPLPKI-KRLLASSVPELRGQFPLS 1349 Query: 567 YNMVLNLL 574 +VL L+ Sbjct: 1350 ITLVLRLM 1357 Score = 72.4 bits (176), Expect = 2e-12 Identities = 57/190 (30%), Positives = 89/190 (46%), Gaps = 19/190 (10%) Query: 122 YLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALRE 181 YL R + + FI +A+Q+E + VD N+S ++ A TS+GKT + Y + LRE Sbjct: 726 YLIRDERKDRDPRVQDFIPNAWQQELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLRE 785 Query: 182 KQ--RVIFTSPIKALSNQKYREMYEEFQDV--------GLMTGDVTINPTASCLVMTT-- 229 V++ +P K+L Q + F G T D N +C V+ T Sbjct: 786 SDVGVVVYVAPAKSLVGQVAATVENRFTKTLPAGRTLCGAFTRDYCHN-VLNCQVLITVP 844 Query: 230 ---EILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATI 286 EIL +R V R + +VIFDE+HY+ WE ++++ ++ LSATI Sbjct: 845 ECFEILLLAPHRQKWVER-IRYVIFDEVHYLGREVGAKFWELLLVII--RCPFLVLSATI 901 Query: 287 PNARQFAEWI 296 N +W+ Sbjct: 902 NNPNLLTKWL 911 >gi|222831595 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 [Homo sapiens] Length = 1712 Score = 80.5 bits (197), Expect = 8e-15 Identities = 50/133 (37%), Positives = 75/133 (56%), Gaps = 10/133 (7%) Query: 442 EHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNA 501 E + L +RGIG HH + K+ +EILF +G ++ + AT T A+G+NMP ++V+F Sbjct: 1251 EELKALAERGIGYHHSAMSFKEKQLVEILFRKGYLRVVTATGTLALGVNMPCKSVVF--- 1307 Query: 502 RKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNS 561 ++ ++ + Y QMSGRAGRRG D G V + P IGK L+K + L Sbjct: 1308 ----AQNSVYLDALNYRQMSGRAGRRGQDLMGDVYFF--DIPFPKIGK-LIKSNVPELRG 1360 Query: 562 AFHLTYNMVLNLL 574 F L+ +VL L+ Sbjct: 1361 HFPLSITLVLRLM 1373 Score = 77.4 bits (189), Expect = 6e-14 Identities = 54/174 (31%), Positives = 88/174 (50%), Gaps = 19/174 (10%) Query: 138 FILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQR--VIFTSPIKALS 195 FI D +QRE + VD N+S ++ A TS+GKT + Y + L+E V++ +P KAL Sbjct: 762 FIPDTWQRELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLKESDDGVVVYVAPTKALV 821 Query: 196 NQKYREMYEEFQDVGLMTGDVTI--------NPTASCLVMTT-----EILRSMLYRGSEV 242 NQ + F L +G+V + +C V+ T EIL +R + V Sbjct: 822 NQVAATVQNRFTK-NLPSGEVLCGVFTREYRHDALNCQVLITVPACFEILLLAPHRQNWV 880 Query: 243 MREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWI 296 +++ +VIFDE+H + +WE ++++ ++ LSATI N EW+ Sbjct: 881 -KKIRYVIFDEVHCLGGEIGAEIWEHLLVMI--RCPFLALSATISNPEHLTEWL 931 >gi|14591902 RecQ protein-like [Homo sapiens] Length = 649 Score = 41.2 bits (95), Expect = 0.005 Identities = 37/106 (34%), Positives = 47/106 (44%), Gaps = 12/106 (11%) Query: 425 SNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATET 484 S I C S +D + QV L L G +H L P K T+ +S I+ + AT Sbjct: 316 SGIIYCFSQKDSE--QVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVA 373 Query: 485 FAMGINMP-ARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGM 529 F MGI+ P R V+ + K S Y Q SGRAGR M Sbjct: 374 FGMGIDKPDVRFVIHHSMSK---------SMENYYQESGRAGRDDM 410 >gi|14591904 RecQ protein-like [Homo sapiens] Length = 649 Score = 41.2 bits (95), Expect = 0.005 Identities = 37/106 (34%), Positives = 47/106 (44%), Gaps = 12/106 (11%) Query: 425 SNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATET 484 S I C S +D + QV L L G +H L P K T+ +S I+ + AT Sbjct: 316 SGIIYCFSQKDSE--QVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVA 373 Query: 485 FAMGINMP-ARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGM 529 F MGI+ P R V+ + K S Y Q SGRAGR M Sbjct: 374 FGMGIDKPDVRFVIHHSMSK---------SMENYYQESGRAGRDDM 410 >gi|51094101 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 2 [Homo sapiens] Length = 881 Score = 39.3 bits (90), Expect = 0.020 Identities = 39/160 (24%), Positives = 65/160 (40%), Gaps = 16/160 (10%) Query: 144 QREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQ-----RVIFTSPIKALSNQK 198 QR+ I + + + V+ A T +GKT C + L+ R + SP + L+ Q Sbjct: 123 QRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERLKTHSAQTGARALILSPTRELALQT 182 Query: 199 YREMYEEFQDVGLMT-----GD------VTINPTASCLVMTTEILRSMLYRGSEVMREVA 247 + E + GL T GD ++ ++ T L + S ++ V Sbjct: 183 LKFTKELGKFTGLKTALILGGDRMEDQFAALHENPDIIIATPGRLVHVAVEMSLKLQSVE 242 Query: 248 WVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIP 287 +V+FDE + + +E I LP V SAT+P Sbjct: 243 YVVFDEADRLFEMGFAEQLQEIIARLPGGHQTVLFSATLP 282 >gi|164419743 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 1 [Homo sapiens] Length = 882 Score = 39.3 bits (90), Expect = 0.020 Identities = 39/160 (24%), Positives = 65/160 (40%), Gaps = 16/160 (10%) Query: 144 QREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQ-----RVIFTSPIKALSNQK 198 QR+ I + + + V+ A T +GKT C + L+ R + SP + L+ Q Sbjct: 123 QRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERLKTHSAQTGARALILSPTRELALQT 182 Query: 199 YREMYEEFQDVGLMT-----GD------VTINPTASCLVMTTEILRSMLYRGSEVMREVA 247 + E + GL T GD ++ ++ T L + S ++ V Sbjct: 183 LKFTKELGKFTGLKTALILGGDRMEDQFAALHENPDIIIATPGRLVHVAVEMSLKLQSVE 242 Query: 248 WVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIP 287 +V+FDE + + +E I LP V SAT+P Sbjct: 243 YVVFDEADRLFEMGFAEQLQEIIARLPGGHQTVLFSATLP 282 >gi|31543667 suppressor of var1, 3-like 1 [Homo sapiens] Length = 786 Score = 38.9 bits (89), Expect = 0.026 Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 8/92 (8%) Query: 477 KALFATETFAMGINMPARTVLF-----TNARKFDGKDFRWISSGEYIQMSGRAGR-RGMD 530 K L AT+ MG+N+ R ++F + + ++ I++ + +Q++GRAGR Sbjct: 419 KILVATDAIGMGLNLSIRRIIFYSLIKPSINEKGERELEPITTSQALQIAGRAGRFSSRF 478 Query: 531 DRGIVILMVDEKMSPTIGKQLLKGSADPLNSA 562 G V M E +S + K++LK DP+ +A Sbjct: 479 KEGEVTTMNHEDLS--LLKEILKRPVDPIRAA 508 Score = 32.3 bits (72), Expect = 2.4 Identities = 34/125 (27%), Positives = 54/125 (43%), Gaps = 18/125 (14%) Query: 160 SAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGD--VT 217 S T++GKT +AI K V + P+K L+++ + + L+TG+ VT Sbjct: 206 SGPTNSGKTY---HAIQKYFSAKSGV-YCGPLKLLAHEIFEKSNAAGVPCDLVTGEERVT 261 Query: 218 INPT---ASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETII-LL 273 + P AS + T E+ V + DEI +RD RG W ++ L Sbjct: 262 VQPNGKQASHVSCTVEMC--------SVTTPYEVAVIDEIQMIRDPARGWAWTRALLGLC 313 Query: 274 PDNVH 278 + VH Sbjct: 314 AEEVH 318 >gi|13129006 nucleolar protein GU2 [Homo sapiens] Length = 737 Score = 35.4 bits (80), Expect = 0.28 Identities = 37/164 (22%), Positives = 68/164 (41%), Gaps = 16/164 (9%) Query: 371 PSNVFKIVKMIMERNFQPV-IIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVF----- 424 P V+K+ K M+ ++ V ++ ++K A ++ + + + ++ +V Sbjct: 330 PQWVYKVAKKYMKSRYEQVDLVGKMTQK--AATTVEHLAIQCHWSQRPAVIGDVLQVYSG 387 Query: 425 SNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATET 484 S + E KK + P +K+ HG + +E F EG K L AT Sbjct: 388 SEGRAIIFCETKKNVTEMAMNPHIKQNAQCLHGDIAQSQREITLKGFREGSFKVLVATNV 447 Query: 485 FAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRG 528 A G+++P ++ ++ D + YI SGR GR G Sbjct: 448 AARGLDIPEVDLVIQSSPPQDVES--------YIHRSGRTGRAG 483 >gi|167830436 DEAH (Asp-Glu-Ala-His) box polypeptide 36 isoform 2 [Homo sapiens] Length = 994 Score = 35.0 bits (79), Expect = 0.37 Identities = 44/175 (25%), Positives = 78/175 (44%), Gaps = 33/175 (18%) Query: 144 QREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQ-----RVIFTSP--IKALSN 196 Q+E + +DN+Q ++S T GKT I E+ R++ T P I A+S Sbjct: 213 QKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISV 272 Query: 197 QKYREMYEEFQDVGLMTGDVT----------INPTASCLVMTTEILRSMLYRGSEVMREV 246 + R E + G +G+ T S L TT I+ L + + V Sbjct: 273 AE-RVAAERAESCG--SGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWL-QSDPYLSSV 328 Query: 247 AWVIFDEIHYMRDSERGVVWEETIILLPDNVHY------VFLSATIPNARQFAEW 295 + ++ DEIH ER + + + ++ D +++ + +SAT+ NA +F+E+ Sbjct: 329 SHIVLDEIH-----ERNLQSDVLMTVVKDLLNFRSDLKVILMSATL-NAEKFSEY 377 >gi|167830433 DEAH (Asp-Glu-Ala-His) box polypeptide 36 isoform 1 [Homo sapiens] Length = 1008 Score = 35.0 bits (79), Expect = 0.37 Identities = 44/175 (25%), Positives = 78/175 (44%), Gaps = 33/175 (18%) Query: 144 QREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQ-----RVIFTSP--IKALSN 196 Q+E + +DN+Q ++S T GKT I E+ R++ T P I A+S Sbjct: 213 QKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISV 272 Query: 197 QKYREMYEEFQDVGLMTGDVT----------INPTASCLVMTTEILRSMLYRGSEVMREV 246 + R E + G +G+ T S L TT I+ L + + V Sbjct: 273 AE-RVAAERAESCG--SGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWL-QSDPYLSSV 328 Query: 247 AWVIFDEIHYMRDSERGVVWEETIILLPDNVHY------VFLSATIPNARQFAEW 295 + ++ DEIH ER + + + ++ D +++ + +SAT+ NA +F+E+ Sbjct: 329 SHIVLDEIH-----ERNLQSDVLMTVVKDLLNFRSDLKVILMSATL-NAEKFSEY 377 >gi|122937345 myosin VB [Homo sapiens] Length = 1848 Score = 34.7 bits (78), Expect = 0.48 Identities = 21/57 (36%), Positives = 34/57 (59%), Gaps = 10/57 (17%) Query: 152 DNNQSVLVSAHTSAGKTVCAEYAI---------ALALREKQRVIFTSPI-KALSNQK 198 + NQS++VS + AGKTV A+YA+ A +++V+ +SPI +A+ N K Sbjct: 154 EKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLASSPIMEAIGNAK 210 >gi|116812616 RecQ protein-like 4 [Homo sapiens] Length = 1208 Score = 34.3 bits (77), Expect = 0.63 Identities = 22/75 (29%), Positives = 34/75 (45%), Gaps = 10/75 (13%) Query: 455 HHGGLLPILKETIEILFSEGLIKALFATETFAMGINMP-ARTVLFTNARKFDGKDFRWIS 513 +H G+ + ++ F +G ++ + AT F MG++ P R VL S Sbjct: 744 YHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPP---------S 794 Query: 514 SGEYIQMSGRAGRRG 528 Y+Q GRAGR G Sbjct: 795 FESYVQAVGRAGRDG 809 >gi|110735439 Werner syndrome protein [Homo sapiens] Length = 1432 Score = 33.9 bits (76), Expect = 0.82 Identities = 30/95 (31%), Positives = 38/95 (40%), Gaps = 10/95 (10%) Query: 436 KKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGIN-MPAR 494 K QV L L G +H G+ ++ I F I+ + AT F MGIN R Sbjct: 775 KMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIR 834 Query: 495 TVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGM 529 V+ A K Y Q GRAGR G+ Sbjct: 835 QVIHYGAPK---------DMESYYQEIGRAGRDGL 860 >gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent helicase, partial [Homo sapiens] Length = 1140 Score = 33.9 bits (76), Expect = 0.82 Identities = 30/95 (31%), Positives = 38/95 (40%), Gaps = 10/95 (10%) Query: 436 KKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGIN-MPAR 494 K QV L L G +H G+ ++ I F I+ + AT F MGIN R Sbjct: 483 KMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIR 542 Query: 495 TVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGM 529 V+ A K Y Q GRAGR G+ Sbjct: 543 QVIHYGAPK---------DMESYYQEIGRAGRDGL 568 >gi|224593278 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Homo sapiens] Length = 796 Score = 33.1 bits (74), Expect = 1.4 Identities = 50/266 (18%), Positives = 112/266 (42%), Gaps = 24/266 (9%) Query: 388 PVIIFSFSKKDCEAYALQ-MTKLDFNTDEEKK-----MVEEVFSNAIDCLSDEDKKLPQV 441 PV IF S D + Q ++ N + +++ ++ F++ + + K+ ++ Sbjct: 420 PVRIFVNSNTDVAPFLRQEFIRIRPNREGDREAIVAALLTRTFTDHVMLFTQTKKQAHRM 479 Query: 442 EHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPA-RTVL-FT 499 +L L+ +G HG L + F + I L AT+ A G+++ +TV+ FT Sbjct: 480 HILLGLMGLQVGELHGNLSQTQRLEALRRFKDEQIDILVATDVAARGLDIEGVKTVINFT 539 Query: 500 NARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPL 559 Y+ GR R G R + ++ DE+ + K+++K + P+ Sbjct: 540 MPNTIK----------HYVHRVGRTARAGRAGRSVSLVGEDER---KMLKEIVKAAKAPV 586 Query: 560 NSAFHLTYNMVLNLL-RVEEINPE-YMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVI 617 + L +++L ++E++ + Y + + + + + + K E+ + V+ Sbjct: 587 KARI-LPQDVILKFRDKIEKMEKDVYAVLQLEAEEKEMQQSEAQINTAKRLLEKGKEAVV 645 Query: 618 PNEESVVIYYKIRQQLAKLGKEIEEY 643 E K ++ K+ K ++E+ Sbjct: 646 QEPERSWFQTKEERKKEKIAKALQEF 671 >gi|215982794 myosin VA isoform 2 [Homo sapiens] Length = 1828 Score = 32.7 bits (73), Expect = 1.8 Identities = 19/57 (33%), Positives = 34/57 (59%), Gaps = 10/57 (17%) Query: 152 DNNQSVLVSAHTSAGKTVCAEYAI---------ALALREKQRVIFTSPI-KALSNQK 198 + NQS++VS + AGKTV A+YA+ A +++V+ ++PI +++ N K Sbjct: 154 ERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAK 210 >gi|215982791 myosin VA isoform 1 [Homo sapiens] Length = 1855 Score = 32.7 bits (73), Expect = 1.8 Identities = 19/57 (33%), Positives = 34/57 (59%), Gaps = 10/57 (17%) Query: 152 DNNQSVLVSAHTSAGKTVCAEYAI---------ALALREKQRVIFTSPI-KALSNQK 198 + NQS++VS + AGKTV A+YA+ A +++V+ ++PI +++ N K Sbjct: 154 ERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAK 210 >gi|42415492 chromosome 14 open reading frame 106 [Homo sapiens] Length = 1132 Score = 32.0 bits (71), Expect = 3.1 Identities = 24/103 (23%), Positives = 42/103 (40%), Gaps = 31/103 (30%) Query: 365 KGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQM------------------ 406 K T S +F +VK ++ P ++ S ++ DC+ Y +M Sbjct: 1020 KNPTTPSSVIFPLVKTPQCQHVSPGMLGSINRNDCDKYVFRMQKYHKSNGGIVWGNIKKK 1079 Query: 407 ------------TKLDFNTD-EEKKMVEEVFSNAIDCLSDEDK 436 K FNTD E + ++F+NA++ L +E+K Sbjct: 1080 LVETDFSTPTPRRKTPFNTDLGENSGIGKLFTNAVESLDEEEK 1122 >gi|14550416 Fc receptor-like 4 precursor [Homo sapiens] Length = 515 Score = 31.6 bits (70), Expect = 4.1 Identities = 32/125 (25%), Positives = 55/125 (44%), Gaps = 19/125 (15%) Query: 10 FSVFEGDSTTAAGTKKDKEK---DKGKWKGPPGSADKAGKRFDGKLQSESTNNGKNKRDV 66 +SVFEGD+ ++ KEK K W G + K +D + S+NN N R + Sbjct: 111 YSVFEGDTLVLRCHRRRKEKLTAVKYTWNG--NILSISNKSWDLLIPQASSNNNGNYRCI 168 Query: 67 DFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVET--VEG----CTHEVALPAEE 120 + G + +F +I + + +L P ++++ ++ EG + E LP E Sbjct: 169 GY-GDENDVFRSNFKI-------IKIQELFPHPELKATDSQPTEGNSVNLSCETQLPPER 220 Query: 121 DYLPL 125 PL Sbjct: 221 SDTPL 225 >gi|13376617 prostaglandin E synthase 2 [Homo sapiens] Length = 377 Score = 31.2 bits (69), Expect = 5.3 Identities = 23/85 (27%), Positives = 43/85 (50%), Gaps = 17/85 (20%) Query: 575 RVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYN--KIVI-----------PNEE 621 +V E+NP + ++ +F YR +P +V + S +Q N ++I P EE Sbjct: 128 QVVEVNP---VRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEE 184 Query: 622 SVVIYYKIRQQLAKLGKEIEEYIHK 646 ++ YY + + + GKE+ E+ +K Sbjct: 185 -IITYYPAMKAVNEQGKEVTEFGNK 208 >gi|51599156 chromodomain helicase DNA binding protein 4 [Homo sapiens] Length = 1912 Score = 31.2 bits (69), Expect = 5.3 Identities = 20/81 (24%), Positives = 35/81 (43%) Query: 15 GDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNGKNKRDVDFEGTDEP 74 GDS+ ++E++ GS GK+ KL + K+KR + E D+ Sbjct: 83 GDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDD 142 Query: 75 IFGKKPRIEESITEDLSLADL 95 K+P+ + ED + D+ Sbjct: 143 DDSKEPKSSAQLLEDWGMEDI 163 >gi|153945715 myosin VC [Homo sapiens] Length = 1742 Score = 31.2 bits (69), Expect = 5.3 Identities = 13/24 (54%), Positives = 18/24 (75%) Query: 152 DNNQSVLVSAHTSAGKTVCAEYAI 175 + NQS++VS + AGKTV A YA+ Sbjct: 152 NRNQSIIVSGESGAGKTVSARYAM 175 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.135 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 37,692,093 Number of Sequences: 37866 Number of extensions: 1698923 Number of successful extensions: 4594 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 16 Number of HSP's successfully gapped in prelim test: 22 Number of HSP's that attempted gapping in prelim test: 4512 Number of HSP's gapped (non-prelim): 70 length of query: 1042 length of database: 18,247,518 effective HSP length: 112 effective length of query: 930 effective length of database: 14,006,526 effective search space: 13026069180 effective search space used: 13026069180 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.