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Search of human proteins with 193083134
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|193083134 melanocortin 1 receptor [Homo sapiens]
(317 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|193083134 melanocortin 1 receptor [Homo sapiens] 624 e-179
gi|119508433 melanocortin 4 receptor [Homo sapiens] 293 1e-79
gi|170671732 melanocortin 3 receptor [Homo sapiens] 286 2e-77
gi|5174535 melanocortin 5 receptor [Homo sapiens] 275 4e-74
gi|4505127 melanocortin 2 receptor [Homo sapiens] 223 1e-58
gi|4885295 G protein-coupled receptor 12 [Homo sapiens] 108 6e-24
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 102 6e-22
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 102 6e-22
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 102 6e-22
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 102 6e-22
gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] 99 4e-21
gi|134244587 endothelial differentiation, sphingolipid G-protein... 99 6e-21
gi|4885341 G protein-coupled receptor 6 [Homo sapiens] 98 1e-20
gi|4885325 G protein-coupled receptor 3 [Homo sapiens] 97 2e-20
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 92 6e-19
gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] 89 4e-18
gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] 89 4e-18
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 88 9e-18
gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] 84 2e-16
gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] 84 2e-16
gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] 84 2e-16
gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] 84 2e-16
gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] 84 2e-16
gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] 84 2e-16
gi|115305569 adenosine A1 receptor [Homo sapiens] 82 5e-16
gi|4501947 adenosine A1 receptor [Homo sapiens] 82 5e-16
gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens] 82 6e-16
gi|13540517 endothelial differentiation, sphingolipid G-protein-... 78 9e-15
gi|223633986 trace amine associated receptor 5 [Homo sapiens] 77 2e-14
gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens] 75 6e-14
>gi|193083134 melanocortin 1 receptor [Homo sapiens]
Length = 317
Score = 624 bits (1609), Expect = e-179
Identities = 317/317 (100%), Positives = 317/317 (100%)
Query: 1 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV 60
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
Sbjct: 1 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV 60
Query: 61 ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI 120
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
Sbjct: 61 ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI 120
Query: 121 DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI 180
DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
Sbjct: 121 DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI 180
Query: 181 AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA 240
AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
Sbjct: 181 AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA 240
Query: 241 VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF 300
VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
Sbjct: 241 VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF 300
Query: 301 HSQELRRTLKEVLTCSW 317
HSQELRRTLKEVLTCSW
Sbjct: 301 HSQELRRTLKEVLTCSW 317
>gi|119508433 melanocortin 4 receptor [Homo sapiens]
Length = 332
Score = 293 bits (750), Expect = 1e-79
Identities = 146/279 (52%), Positives = 197/279 (70%), Gaps = 2/279 (0%)
Query: 37 EVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETA 96
++ +S +F++LG++SL+EN LV+ IAKN+NLHSPMY FIC LA++D+LVS SN ET
Sbjct: 43 QLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETI 102
Query: 97 VILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIV 156
VI LL + A++ + +DNVID + CSS+L+S+C L +IAVDRY +IFYAL+YH+I+
Sbjct: 103 VITLLNSTDTDAQSFTVN-IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIM 161
Query: 157 TLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQ 216
T+ R ++ IW A V LFI Y D AV++CL+ F ML LMA LYVHM A
Sbjct: 162 TVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARL 221
Query: 217 HAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCI 276
H + IA L + QG +KGA+TLTIL+G+F +CW PFFLHL + CP++P C C
Sbjct: 222 HIKRIAVL-PGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCF 280
Query: 277 FKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTC 315
+FNL+L LI+CN+IIDPLIYA SQELR+T KE++ C
Sbjct: 281 MSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICC 319
>gi|170671732 melanocortin 3 receptor [Homo sapiens]
Length = 323
Score = 286 bits (732), Expect = 2e-77
Identities = 142/284 (50%), Positives = 192/284 (67%), Gaps = 1/284 (0%)
Query: 31 TGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGS 90
+ A C +V I +FLSLG+VSL+EN LV+ + +N NLHSPMY F+C LA++D+LVS S
Sbjct: 31 SSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVS 90
Query: 91 NVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYAL 150
N LET +I ++ + L +Q +DN+ D + C S+++S+C L AIAVDRY++IFYAL
Sbjct: 91 NALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYAL 150
Query: 151 RYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHM 210
RYHSI+T+ +A + AIWV V +FI Y + V++CL+ F AM++LM LYVHM
Sbjct: 151 RYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHM 210
Query: 211 LARACQHAQGIARLHKRQRPVHQGFG-LKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPE 269
A H + IA L Q +KGAVT+TILLG+F CW PFFLHL LI+ CP
Sbjct: 211 FLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPT 270
Query: 270 HPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVL 313
+P C C +FN +L LI+CN++IDPLIYAF S ELR T +E+L
Sbjct: 271 NPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREIL 314
>gi|5174535 melanocortin 5 receptor [Homo sapiens]
Length = 325
Score = 275 bits (703), Expect = 4e-74
Identities = 135/281 (48%), Positives = 191/281 (67%), Gaps = 1/281 (0%)
Query: 35 CLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLE 94
C ++ I+ +FL+LG++SL+EN LV+ I KN+NLHSPMY F+C LA++D+LVS S+ E
Sbjct: 33 CEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWE 92
Query: 95 TAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHS 154
T I LL LV A ++ +DNV D + C S+++S+C L AIAVDRY++IFYALRYH
Sbjct: 93 TITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHH 152
Query: 155 IVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARA 214
I+T R+ +A IW +FI Y + V+LCL+ F AML L+ LY+HM A
Sbjct: 153 IMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLA 212
Query: 215 CQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCG 274
H + IA L Q ++GAVT+T+LLG+F +CW PFFLHLTL++ CP++ C
Sbjct: 213 RTHVKRIAAL-PGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCS 271
Query: 275 CIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTC 315
+FN++L LI+CN+++DPLIYAF SQE+R+T KE++ C
Sbjct: 272 RFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICC 312
>gi|4505127 melanocortin 2 receptor [Homo sapiens]
Length = 297
Score = 223 bits (569), Expect = 1e-58
Identities = 115/282 (40%), Positives = 163/282 (57%), Gaps = 8/282 (2%)
Query: 35 CLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLE 94
C V + + +F ++ +V ++EN +V+ + KN+NL +PMY FIC LA+SD+L S +LE
Sbjct: 21 CPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILE 80
Query: 95 TAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHS 154
+I+L G L R + D++ID + S+L S+ L IA DRYI+IF+ALRYHS
Sbjct: 81 NILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHS 140
Query: 155 IVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARA 214
IVT+ R + IW + + HV ++ F MLV + LYVHM A
Sbjct: 141 IVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLA 200
Query: 215 CQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCG 274
H + I+ L + +KGA+TLTILLG+F CW PF LH+ L+ CP +P C
Sbjct: 201 RSHTRKISTLPRA--------NMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCA 252
Query: 275 CIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCS 316
C F + LI+CNA+IDP IYAF S ELR K+++ CS
Sbjct: 253 CYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCS 294
>gi|4885295 G protein-coupled receptor 12 [Homo sapiens]
Length = 334
Score = 108 bits (270), Expect = 6e-24
Identities = 93/288 (32%), Positives = 137/288 (47%), Gaps = 31/288 (10%)
Query: 36 LEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLET 95
L V+ D + + G + ENA+VV I N +L +PM+ I LAL+DLL +G ++
Sbjct: 42 LVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLL-AGIGLITN 100
Query: 96 AVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSI 155
V L L + A L + ++ +S +S+C L AI VDRY+S++YAL YHS
Sbjct: 101 FVFAYL----LQSEATKLVTIGLIV-----ASFSASVCSLLAITVDRYLSLYYALTYHSE 151
Query: 156 VTLPRARRAVAAIWVASVVFSTLFIAYYDHVAV--------------LLCLVVFFLAMLV 201
T+ + +W S+ L + ++ + L V FL M
Sbjct: 152 RTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFA 211
Query: 202 LMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHL 261
LM LY+ + +HA IA H H KG TL I+LG F CW PF
Sbjct: 212 LMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPF---- 267
Query: 262 TLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTL 309
TL L ++ T I+ L A N+II+P+IYAF +QE+++ L
Sbjct: 268 TLYSLIADY-TYPSIYTYATLLPATY--NSIINPVIYAFRNQEIQKAL 312
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 102 bits (253), Expect = 6e-22
Identities = 89/331 (26%), Positives = 150/331 (45%), Gaps = 65/331 (19%)
Query: 38 VSISDGLFLSLGLVSLV-----ENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNV 92
V+IS + L + L L+ N LV+ ++A +R+LHS + +I LA++DLL++ + +
Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80
Query: 93 LETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRY 152
+A+ +L A V + +DV+ C++ + LC I++DRYI + Y LRY
Sbjct: 81 PFSAIFEVLGYWAF---GRVFCNIWAAVDVLCCTASIMGLCI---ISIDRYIGVSYPLRY 134
Query: 153 HSIVTLPRARRAVAAIWVASVVFS---------------TLFIAYYDHVAVLLCLVVFFL 197
+IVT R A+ +W S+V S T+ + VL + F
Sbjct: 135 PTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFY 194
Query: 198 AMLVLMAVLYVHMLARACQHAQGI---------------ARLHKRQRPVHQGFGL----- 237
L ++ V+Y + A + ++G+ R+H++ P G G+
Sbjct: 195 LPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPA-GGSGMASAKT 253
Query: 238 ---------------KGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNL 282
K A TL I++G F LCW PFFL + + P+ +FK +
Sbjct: 254 KTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFK---I 310
Query: 283 FLALIICNAIIDPLIYAFHSQELRRTLKEVL 313
L N+ I+P+IY SQE ++ + VL
Sbjct: 311 VFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 102 bits (253), Expect = 6e-22
Identities = 89/331 (26%), Positives = 150/331 (45%), Gaps = 65/331 (19%)
Query: 38 VSISDGLFLSLGLVSLV-----ENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNV 92
V+IS + L + L L+ N LV+ ++A +R+LHS + +I LA++DLL++ + +
Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80
Query: 93 LETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRY 152
+A+ +L A V + +DV+ C++ + LC I++DRYI + Y LRY
Sbjct: 81 PFSAIFEVLGYWAF---GRVFCNIWAAVDVLCCTASIMGLCI---ISIDRYIGVSYPLRY 134
Query: 153 HSIVTLPRARRAVAAIWVASVVFS---------------TLFIAYYDHVAVLLCLVVFFL 197
+IVT R A+ +W S+V S T+ + VL + F
Sbjct: 135 PTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFY 194
Query: 198 AMLVLMAVLYVHMLARACQHAQGI---------------ARLHKRQRPVHQGFGL----- 237
L ++ V+Y + A + ++G+ R+H++ P G G+
Sbjct: 195 LPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPA-GGSGMASAKT 253
Query: 238 ---------------KGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNL 282
K A TL I++G F LCW PFFL + + P+ +FK +
Sbjct: 254 KTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFK---I 310
Query: 283 FLALIICNAIIDPLIYAFHSQELRRTLKEVL 313
L N+ I+P+IY SQE ++ + VL
Sbjct: 311 VFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 102 bits (253), Expect = 6e-22
Identities = 89/331 (26%), Positives = 150/331 (45%), Gaps = 65/331 (19%)
Query: 38 VSISDGLFLSLGLVSLV-----ENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNV 92
V+IS + L + L L+ N LV+ ++A +R+LHS + +I LA++DLL++ + +
Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80
Query: 93 LETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRY 152
+A+ +L A V + +DV+ C++ + LC I++DRYI + Y LRY
Sbjct: 81 PFSAIFEVLGYWAF---GRVFCNIWAAVDVLCCTASIMGLCI---ISIDRYIGVSYPLRY 134
Query: 153 HSIVTLPRARRAVAAIWVASVVFS---------------TLFIAYYDHVAVLLCLVVFFL 197
+IVT R A+ +W S+V S T+ + VL + F
Sbjct: 135 PTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFY 194
Query: 198 AMLVLMAVLYVHMLARACQHAQGI---------------ARLHKRQRPVHQGFGL----- 237
L ++ V+Y + A + ++G+ R+H++ P G G+
Sbjct: 195 LPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPA-GGSGMASAKT 253
Query: 238 ---------------KGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNL 282
K A TL I++G F LCW PFFL + + P+ +FK +
Sbjct: 254 KTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFK---I 310
Query: 283 FLALIICNAIIDPLIYAFHSQELRRTLKEVL 313
L N+ I+P+IY SQE ++ + VL
Sbjct: 311 VFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 102 bits (253), Expect = 6e-22
Identities = 89/331 (26%), Positives = 150/331 (45%), Gaps = 65/331 (19%)
Query: 38 VSISDGLFLSLGLVSLV-----ENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNV 92
V+IS + L + L L+ N LV+ ++A +R+LHS + +I LA++DLL++ + +
Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80
Query: 93 LETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRY 152
+A+ +L A V + +DV+ C++ + LC I++DRYI + Y LRY
Sbjct: 81 PFSAIFEVLGYWAF---GRVFCNIWAAVDVLCCTASIMGLCI---ISIDRYIGVSYPLRY 134
Query: 153 HSIVTLPRARRAVAAIWVASVVFS---------------TLFIAYYDHVAVLLCLVVFFL 197
+IVT R A+ +W S+V S T+ + VL + F
Sbjct: 135 PTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFY 194
Query: 198 AMLVLMAVLYVHMLARACQHAQGI---------------ARLHKRQRPVHQGFGL----- 237
L ++ V+Y + A + ++G+ R+H++ P G G+
Sbjct: 195 LPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPA-GGSGMASAKT 253
Query: 238 ---------------KGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNL 282
K A TL I++G F LCW PFFL + + P+ +FK +
Sbjct: 254 KTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFK---I 310
Query: 283 FLALIICNAIIDPLIYAFHSQELRRTLKEVL 313
L N+ I+P+IY SQE ++ + VL
Sbjct: 311 VFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens]
Length = 382
Score = 99.4 bits (246), Expect = 4e-21
Identities = 84/298 (28%), Positives = 142/298 (47%), Gaps = 34/298 (11%)
Query: 38 VSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAV 97
+ ++ +F+ + ++EN V+ TI K + H PMY FI LALSDLL + V TA
Sbjct: 45 IKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLL---AGVAYTAN 101
Query: 98 ILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVT 157
+LL A A + + V +S+ S L AIA++RYI++ ++ H+
Sbjct: 102 LLLSGATTYKLTPAQWFLREGSMFVALSASVFSLL----AIAIERYITML-KMKLHNGSN 156
Query: 158 LPRARRAVAAIWVASVVF-----------------STLFIAYYDHVAVLLCLVVFFLAML 200
R ++A WV S++ ST+ Y+ H +L C VF L +L
Sbjct: 157 NFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHY-ILFCTTVFTL-LL 214
Query: 201 VLMAVLYVHMLARACQHAQGIA---RLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPF 257
+ + +LY + + ++ + + K R + L T+ I+L +F CW P
Sbjct: 215 LSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLAL--LKTVIIVLSVFIACWAPL 272
Query: 258 FLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTC 315
F+ L L V C + TC +F+ FL L + N+ +P+IY ++E+RR +++C
Sbjct: 273 FILLLLDVGC-KVKTCDILFR-AEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSC 328
>gi|134244587 endothelial differentiation, sphingolipid
G-protein-coupled receptor, 5 [Homo sapiens]
Length = 353
Score = 98.6 bits (244), Expect = 6e-21
Identities = 86/294 (29%), Positives = 136/294 (46%), Gaps = 41/294 (13%)
Query: 40 ISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVIL 99
++ + L +VEN LV+ +A+N HS MY F+ LA SDLL + V T
Sbjct: 35 VASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANT---- 90
Query: 100 LLEAGALVARAAVLQQLDNVIDV-ITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTL 158
L +G++ R +Q IT S+ + SL AIA++R+++I Y S +
Sbjct: 91 -LLSGSVTLRLTPVQWFAREGSAFITLSASVFSLL---AIAIERHVAIAKVKLYGSDKSC 146
Query: 159 PRARRAVAAIWVASVVF-----------------STLFIAYYDHVAVLLCLVVFFLAMLV 201
R + A W+ S+V ST+ Y H +LC+V F +L+
Sbjct: 147 -RMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKH--YVLCVVTIFSIILL 203
Query: 202 LMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHL 261
+ LYV + + R Q L T+TI+LG+F +CW P F L
Sbjct: 204 AIVALYVRIYC--------VVRSSHADMAAPQTLAL--LKTVTIVLGVFIVCWLPAFSIL 253
Query: 262 TLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTC 315
L CP H +C ++K + F A+ N++++P+IY + S++LRR + L C
Sbjct: 254 LLDYACPVH-SCPILYK-AHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQC 305
>gi|4885341 G protein-coupled receptor 6 [Homo sapiens]
Length = 362
Score = 97.8 bits (242), Expect = 1e-20
Identities = 97/306 (31%), Positives = 137/306 (44%), Gaps = 47/306 (15%)
Query: 26 LAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDL 85
L+A G V+ D L G V ENALVVA IA L +PM+ + LA +DL
Sbjct: 60 LSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADL 119
Query: 86 LVSGSNVLE--------TAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGA 137
L +L + + LL G LVA S +S+ L A
Sbjct: 120 LAGCGLILHFVFQYLVPSETVSLLTVGFLVA------------------SFAASVSSLLA 161
Query: 138 IAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAV-LLCLVVFF 196
I VDRY+S++ AL Y+S TL +AA W S+ L + ++ +A C VV
Sbjct: 162 ITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRP 221
Query: 197 LA---MLVLMAVLY------VHMLARACQ----HAQGIARLHKRQRPVHQGFGLKGAVTL 243
LA + +L A + +H+ R CQ HA IA P H KG TL
Sbjct: 222 LARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTL 281
Query: 244 TILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQ 303
++LG F W PF ++ +V E P ++ L A N++I+P+IYAF +Q
Sbjct: 282 AVVLGTFGASWLPFAIY--CVVGSHEDP---AVYTYATLLPATY--NSMINPIIYAFRNQ 334
Query: 304 ELRRTL 309
E++R L
Sbjct: 335 EIQRAL 340
>gi|4885325 G protein-coupled receptor 3 [Homo sapiens]
Length = 330
Score = 97.1 bits (240), Expect = 2e-20
Identities = 78/281 (27%), Positives = 126/281 (44%), Gaps = 31/281 (11%)
Query: 49 GLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVA 108
G + ENALVVA I +PM+ + LA++DLL VL A + + +
Sbjct: 51 GTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSA---- 106
Query: 109 RAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAI 168
++ V+ + + +S+ L AI VDRY+S++ AL Y+S T+ R +A +
Sbjct: 107 ------EMSLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALV 160
Query: 169 WVASV--------------VFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARA 214
W ++ +T + Y L+ L + F + +M LY +
Sbjct: 161 WGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIV 220
Query: 215 CQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCG 274
C+HAQ IA H KG TL ++LG F CW PF ++ +L H
Sbjct: 221 CRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVY---CLLGDAHSPPL 277
Query: 275 CIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTC 315
+ L L N++I+P+IYAF +Q++++ L V C
Sbjct: 278 YTY----LTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCC 314
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 92.0 bits (227), Expect = 6e-19
Identities = 89/330 (26%), Positives = 156/330 (47%), Gaps = 67/330 (20%)
Query: 43 GLFLSLG-LVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLL 101
G+FL+ L+++ N LV+ ++A NR+L + FI LA++DLL+S + + +A + +L
Sbjct: 100 GVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVL 159
Query: 102 EAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRA 161
A + +DV+ C++ + SLC I+VDRY+ + ++L+Y +I+T +A
Sbjct: 160 GFWAF---GRAFCDVWAAVDVLCCTASILSLC---TISVDRYVGVRHSLKYPAIMTERKA 213
Query: 162 RRAVAAIWVASVVFST-LFIAYYDHV---------------AVLLCLVVFFLAMLVLMAV 205
+A +WV ++V S + + + V AV + F+L M V++ V
Sbjct: 214 AAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIV-V 272
Query: 206 LY--VHMLARAC-------------QHAQGIARLHKR----------------------- 227
+Y V+++AR+ + ++ + R+H R
Sbjct: 273 MYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSS 332
Query: 228 --QRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLA 285
R + K A TL I++G+F LCW PFF L L L P+ +FK +
Sbjct: 333 LSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFK---VIFW 389
Query: 286 LIICNAIIDPLIYAFHSQELRRTLKEVLTC 315
L N+ ++PLIY S+E +R +L C
Sbjct: 390 LGYFNSCVNPLIYPCSSREFKRAFLRLLRC 419
>gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 89.4 bits (220), Expect = 4e-18
Identities = 73/291 (25%), Positives = 136/291 (46%), Gaps = 34/291 (11%)
Query: 43 GLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLE 102
GL +++ + ++ N LV+ I NR H P+Y + LA +D + L+
Sbjct: 54 GLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFY-----LMFN 108
Query: 103 AGALVARAAVLQQL--DNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPR 160
G R V L +ID +S+ +S+ L AIA++R+I++F ++ H+ ++ R
Sbjct: 109 TGPNTRRLTVSTWLLRQGLID----TSLTASVANLLAIAIERHITVF-RMQLHTRMSNRR 163
Query: 161 ARRAVAAIWVASVVFSTLFIAYYDHV---------------AVLLCLVVFFLAMLVLMAV 205
+ IW ++V + ++ + + L+ +F L V+M V
Sbjct: 164 VVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVV 223
Query: 206 LYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIV 265
LY H+ Q ++R H ++ + T+ I+LG F +CW P + L L V
Sbjct: 224 LYAHIFGYVRQRTMRMSR-HSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDV 282
Query: 266 LCPEHPTCGCI-FKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTC 315
CP+ C + ++ F FL L N+ ++P+IY++ +E+ T +++L C
Sbjct: 283 CCPQ---CDVLAYEKF--FLLLAEFNSAMNPIIYSYRDKEMSATFRQILCC 328
>gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 89.4 bits (220), Expect = 4e-18
Identities = 73/291 (25%), Positives = 136/291 (46%), Gaps = 34/291 (11%)
Query: 43 GLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLE 102
GL +++ + ++ N LV+ I NR H P+Y + LA +D + L+
Sbjct: 54 GLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFY-----LMFN 108
Query: 103 AGALVARAAVLQQL--DNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPR 160
G R V L +ID +S+ +S+ L AIA++R+I++F ++ H+ ++ R
Sbjct: 109 TGPNTRRLTVSTWLLRQGLID----TSLTASVANLLAIAIERHITVF-RMQLHTRMSNRR 163
Query: 161 ARRAVAAIWVASVVFSTLFIAYYDHV---------------AVLLCLVVFFLAMLVLMAV 205
+ IW ++V + ++ + + L+ +F L V+M V
Sbjct: 164 VVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVV 223
Query: 206 LYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIV 265
LY H+ Q ++R H ++ + T+ I+LG F +CW P + L L V
Sbjct: 224 LYAHIFGYVRQRTMRMSR-HSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDV 282
Query: 266 LCPEHPTCGCI-FKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTC 315
CP+ C + ++ F FL L N+ ++P+IY++ +E+ T +++L C
Sbjct: 283 CCPQ---CDVLAYEKF--FLLLAEFNSAMNPIIYSYRDKEMSATFRQILCC 328
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 88.2 bits (217), Expect = 9e-18
Identities = 88/353 (24%), Positives = 158/353 (44%), Gaps = 72/353 (20%)
Query: 16 STPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYC 75
S+ + +PQL + R + V + G F+ L ++V N LV+ ++A NR+L +P
Sbjct: 32 SSNSTLPQLDIT------RAISVGLVLGAFI---LFAIVGNILVILSVACNRHLRTPTNY 82
Query: 76 FICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFL 135
FI LA++DLL+S + + +A + +L L + + +DV+ C++ + SLC
Sbjct: 83 FIVNLAMADLLLSFTVLPFSAALEVLGYWVL---GRIFCDIWAAVDVLCCTASILSLC-- 137
Query: 136 GAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFS----------------TLF 179
AI++DRYI + Y+L+Y ++VT +A A+ ++WV S V S
Sbjct: 138 -AISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECG 196
Query: 180 IAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGI---------------ARL 224
+ A+ L F++ + V++ V+Y + A + + + R+
Sbjct: 197 VTEEPFYALFSSLGSFYIPLAVIL-VMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRI 255
Query: 225 HKR-------QRPVHQGFGLKGAVTLTIL-----------LGI----FFLCWGPFFLHLT 262
H + +G + ++ + + LGI F LCW PFF+ L
Sbjct: 256 HSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALP 315
Query: 263 LIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTC 315
L L +FK + L N+ ++P+IY S+E +R +L C
Sbjct: 316 LGSLFSTLKPPDAVFK---VVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGC 365
>gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 83.6 bits (205), Expect = 2e-16
Identities = 79/300 (26%), Positives = 135/300 (45%), Gaps = 41/300 (13%)
Query: 44 LFLSLGLVSLVENALVVATIAKNRNLHS-PMYCFICCLALSDLLVSGSNVLETAVILLLE 102
L L+LG +++EN LV+ I +R+L P Y FI LA++DLL GS + + I
Sbjct: 122 LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLL--GSVIFVYSFIDFHV 179
Query: 103 AGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRAR 162
+R L +L V +S +S+ L A+DRYISI L Y IVT P+A
Sbjct: 180 FHRKDSRNVFLFKLGGVT-----ASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAV 234
Query: 163 RAVAAIWVASVVFSTLFIA-------------YYDHV--AVLLCLVVFFLAMLVLMAVLY 207
A +W ++V + L + + H+ L+ + +L+ + Y
Sbjct: 235 VAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAY 294
Query: 208 VHMLARACQHA--------QGIARLHKRQ-------RPVHQGFGLKGAVTLTILLGIFFL 252
+++L +A HA Q +H + RP ++ A TL ++L + +
Sbjct: 295 MYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLII 354
Query: 253 CWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEV 312
CWGP + V + +F ++ L + N+ ++P+IYA S++LR + +
Sbjct: 355 CWGPLLAIMVYDVFGKMNKLIKTVFAFCSM---LCLLNSTVNPIIYALRSKDLRHAFRSM 411
>gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 83.6 bits (205), Expect = 2e-16
Identities = 79/300 (26%), Positives = 135/300 (45%), Gaps = 41/300 (13%)
Query: 44 LFLSLGLVSLVENALVVATIAKNRNLHS-PMYCFICCLALSDLLVSGSNVLETAVILLLE 102
L L+LG +++EN LV+ I +R+L P Y FI LA++DLL GS + + I
Sbjct: 122 LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLL--GSVIFVYSFIDFHV 179
Query: 103 AGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRAR 162
+R L +L V +S +S+ L A+DRYISI L Y IVT P+A
Sbjct: 180 FHRKDSRNVFLFKLGGVT-----ASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAV 234
Query: 163 RAVAAIWVASVVFSTLFIA-------------YYDHV--AVLLCLVVFFLAMLVLMAVLY 207
A +W ++V + L + + H+ L+ + +L+ + Y
Sbjct: 235 VAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAY 294
Query: 208 VHMLARACQHA--------QGIARLHKRQ-------RPVHQGFGLKGAVTLTILLGIFFL 252
+++L +A HA Q +H + RP ++ A TL ++L + +
Sbjct: 295 MYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLII 354
Query: 253 CWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEV 312
CWGP + V + +F ++ L + N+ ++P+IYA S++LR + +
Sbjct: 355 CWGPLLAIMVYDVFGKMNKLIKTVFAFCSM---LCLLNSTVNPIIYALRSKDLRHAFRSM 411
>gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 83.6 bits (205), Expect = 2e-16
Identities = 79/300 (26%), Positives = 135/300 (45%), Gaps = 41/300 (13%)
Query: 44 LFLSLGLVSLVENALVVATIAKNRNLHS-PMYCFICCLALSDLLVSGSNVLETAVILLLE 102
L L+LG +++EN LV+ I +R+L P Y FI LA++DLL GS + + I
Sbjct: 122 LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLL--GSVIFVYSFIDFHV 179
Query: 103 AGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRAR 162
+R L +L V +S +S+ L A+DRYISI L Y IVT P+A
Sbjct: 180 FHRKDSRNVFLFKLGGVT-----ASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAV 234
Query: 163 RAVAAIWVASVVFSTLFIA-------------YYDHV--AVLLCLVVFFLAMLVLMAVLY 207
A +W ++V + L + + H+ L+ + +L+ + Y
Sbjct: 235 VAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAY 294
Query: 208 VHMLARACQHA--------QGIARLHKRQ-------RPVHQGFGLKGAVTLTILLGIFFL 252
+++L +A HA Q +H + RP ++ A TL ++L + +
Sbjct: 295 MYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLII 354
Query: 253 CWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEV 312
CWGP + V + +F ++ L + N+ ++P+IYA S++LR + +
Sbjct: 355 CWGPLLAIMVYDVFGKMNKLIKTVFAFCSM---LCLLNSTVNPIIYALRSKDLRHAFRSM 411
>gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 83.6 bits (205), Expect = 2e-16
Identities = 79/300 (26%), Positives = 135/300 (45%), Gaps = 41/300 (13%)
Query: 44 LFLSLGLVSLVENALVVATIAKNRNLHS-PMYCFICCLALSDLLVSGSNVLETAVILLLE 102
L L+LG +++EN LV+ I +R+L P Y FI LA++DLL GS + + I
Sbjct: 122 LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLL--GSVIFVYSFIDFHV 179
Query: 103 AGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRAR 162
+R L +L V +S +S+ L A+DRYISI L Y IVT P+A
Sbjct: 180 FHRKDSRNVFLFKLGGVT-----ASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAV 234
Query: 163 RAVAAIWVASVVFSTLFIA-------------YYDHV--AVLLCLVVFFLAMLVLMAVLY 207
A +W ++V + L + + H+ L+ + +L+ + Y
Sbjct: 235 VAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAY 294
Query: 208 VHMLARACQHA--------QGIARLHKRQ-------RPVHQGFGLKGAVTLTILLGIFFL 252
+++L +A HA Q +H + RP ++ A TL ++L + +
Sbjct: 295 MYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLII 354
Query: 253 CWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEV 312
CWGP + V + +F ++ L + N+ ++P+IYA S++LR + +
Sbjct: 355 CWGPLLAIMVYDVFGKMNKLIKTVFAFCSM---LCLLNSTVNPIIYALRSKDLRHAFRSM 411
>gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 83.6 bits (205), Expect = 2e-16
Identities = 79/300 (26%), Positives = 135/300 (45%), Gaps = 41/300 (13%)
Query: 44 LFLSLGLVSLVENALVVATIAKNRNLHS-PMYCFICCLALSDLLVSGSNVLETAVILLLE 102
L L+LG +++EN LV+ I +R+L P Y FI LA++DLL GS + + I
Sbjct: 122 LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLL--GSVIFVYSFIDFHV 179
Query: 103 AGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRAR 162
+R L +L V +S +S+ L A+DRYISI L Y IVT P+A
Sbjct: 180 FHRKDSRNVFLFKLGGVT-----ASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAV 234
Query: 163 RAVAAIWVASVVFSTLFIA-------------YYDHV--AVLLCLVVFFLAMLVLMAVLY 207
A +W ++V + L + + H+ L+ + +L+ + Y
Sbjct: 235 VAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAY 294
Query: 208 VHMLARACQHA--------QGIARLHKRQ-------RPVHQGFGLKGAVTLTILLGIFFL 252
+++L +A HA Q +H + RP ++ A TL ++L + +
Sbjct: 295 MYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLII 354
Query: 253 CWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEV 312
CWGP + V + +F ++ L + N+ ++P+IYA S++LR + +
Sbjct: 355 CWGPLLAIMVYDVFGKMNKLIKTVFAFCSM---LCLLNSTVNPIIYALRSKDLRHAFRSM 411
>gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens]
Length = 439
Score = 83.6 bits (205), Expect = 2e-16
Identities = 79/300 (26%), Positives = 135/300 (45%), Gaps = 41/300 (13%)
Query: 44 LFLSLGLVSLVENALVVATIAKNRNLHS-PMYCFICCLALSDLLVSGSNVLETAVILLLE 102
L L+LG +++EN LV+ I +R+L P Y FI LA++DLL GS + + I
Sbjct: 89 LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLL--GSVIFVYSFIDFHV 146
Query: 103 AGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRAR 162
+R L +L V +S +S+ L A+DRYISI L Y IVT P+A
Sbjct: 147 FHRKDSRNVFLFKLGGVT-----ASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAV 201
Query: 163 RAVAAIWVASVVFSTLFIA-------------YYDHV--AVLLCLVVFFLAMLVLMAVLY 207
A +W ++V + L + + H+ L+ + +L+ + Y
Sbjct: 202 VAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAY 261
Query: 208 VHMLARACQHA--------QGIARLHKRQ-------RPVHQGFGLKGAVTLTILLGIFFL 252
+++L +A HA Q +H + RP ++ A TL ++L + +
Sbjct: 262 MYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLII 321
Query: 253 CWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEV 312
CWGP + V + +F ++ L + N+ ++P+IYA S++LR + +
Sbjct: 322 CWGPLLAIMVYDVFGKMNKLIKTVFAFCSM---LCLLNSTVNPIIYALRSKDLRHAFRSM 378
>gi|115305569 adenosine A1 receptor [Homo sapiens]
Length = 326
Score = 82.4 bits (202), Expect = 5e-16
Identities = 77/302 (25%), Positives = 137/302 (45%), Gaps = 45/302 (14%)
Query: 43 GLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLE 102
G+ + + LVS+ N LV+ + N+ L +CFI LA++D+ V G+ V+ A+ L+
Sbjct: 14 GIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAV-GALVIPLAI--LIN 70
Query: 103 AGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRAR 162
G L V+ ++T SS+L+ L AIAVDRY+ + LRY +VT RA
Sbjct: 71 IGPQTYFHTCLMVACPVL-ILTQSSILALL----AIAVDRYLRVKIPLRYKMVVTPRRAA 125
Query: 163 RAVAAIWVASVVFSTLFIAYYDHVA---------------VLLC---------------L 192
A+A W+ S V + +++++ V+ C
Sbjct: 126 VAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNF 185
Query: 193 VVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFL 252
V+ L L+LM ++Y+ + + + G LK A +L ++L +F L
Sbjct: 186 FVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFAL 245
Query: 253 CWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIIC--NAIIDPLIYAFHSQELRRTLK 310
W P + + + CP C + ++A+ + N+ ++P++YAF Q+ R T
Sbjct: 246 SWLPLHILNCITLFCP-----SCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL 300
Query: 311 EV 312
++
Sbjct: 301 KI 302
>gi|4501947 adenosine A1 receptor [Homo sapiens]
Length = 326
Score = 82.4 bits (202), Expect = 5e-16
Identities = 77/302 (25%), Positives = 137/302 (45%), Gaps = 45/302 (14%)
Query: 43 GLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLE 102
G+ + + LVS+ N LV+ + N+ L +CFI LA++D+ V G+ V+ A+ L+
Sbjct: 14 GIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAV-GALVIPLAI--LIN 70
Query: 103 AGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRAR 162
G L V+ ++T SS+L+ L AIAVDRY+ + LRY +VT RA
Sbjct: 71 IGPQTYFHTCLMVACPVL-ILTQSSILALL----AIAVDRYLRVKIPLRYKMVVTPRRAA 125
Query: 163 RAVAAIWVASVVFSTLFIAYYDHVA---------------VLLC---------------L 192
A+A W+ S V + +++++ V+ C
Sbjct: 126 VAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNF 185
Query: 193 VVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFL 252
V+ L L+LM ++Y+ + + + G LK A +L ++L +F L
Sbjct: 186 FVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFAL 245
Query: 253 CWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIIC--NAIIDPLIYAFHSQELRRTLK 310
W P + + + CP C + ++A+ + N+ ++P++YAF Q+ R T
Sbjct: 246 SWLPLHILNCITLFCP-----SCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL 300
Query: 311 EV 312
++
Sbjct: 301 KI 302
>gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens]
Length = 351
Score = 82.0 bits (201), Expect = 6e-16
Identities = 81/292 (27%), Positives = 138/292 (47%), Gaps = 35/292 (11%)
Query: 44 LFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEA 103
L L++ ++ L+ N LV+A IA NR H P+Y + LA +DL + L+
Sbjct: 38 LGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAG-----VAYLFLMFHT 92
Query: 104 GALVARAAV----LQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLP 159
G AR ++ L+Q ++D +S+ +S+ L AIAV+R+ S+ A++ HS +
Sbjct: 93 GPRTARLSLEGWFLRQ--GLLD----TSLTASVATLLAIAVERHRSVM-AVQLHSRLPRG 145
Query: 160 RARRAVAAIWVASVVFSTL---------FIAYYDHVAVLLC---LVVFFLAML---VLMA 204
R + +WVA++ L + +A LL L V+ L+ L +LM
Sbjct: 146 RVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMV 205
Query: 205 VLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLI 264
+Y + + Q +A H P ++ L T+ I+LG F +CW P + L L
Sbjct: 206 AVYTRIFFYVRRRVQRMAE-HVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLD 264
Query: 265 VLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCS 316
L E +C + FL L N++++ +Y+ E+RRT + +L C+
Sbjct: 265 GLGCE--SCNVLAVE-KYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCA 313
>gi|13540517 endothelial differentiation, sphingolipid
G-protein-coupled receptor, 8 [Homo sapiens]
Length = 398
Score = 78.2 bits (191), Expect = 9e-15
Identities = 79/289 (27%), Positives = 129/289 (44%), Gaps = 42/289 (14%)
Query: 53 LVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAV 112
++EN V+ + ++ H+PM+ + L LSDLL + A ILL L A+
Sbjct: 51 VLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYA---ANILLSGPLTLKLSPAL 107
Query: 113 LQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLP-RARRAVAAIWVA 171
+ + V +S+LS L AIA++R S+ A R + V+ R AA W
Sbjct: 108 WFAREGGVFVALTASVLSLL----AIALER--SLTMARRGPAPVSSRGRTLAMAAAAWGV 161
Query: 172 SVVFSTL----------------FIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARAC 215
S++ L + Y VL C V+ F+ +L + LY + +
Sbjct: 162 SLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFC-VLAFVGILAAICALYARIYCQVR 220
Query: 216 QHAQ---------GIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVL 266
+A+ G R++P L TL+++L F CWGP FL L L V
Sbjct: 221 ANARRLPARPGTAGTTSTRARRKPR----SLALLRTLSVVLLAFVACWGPLFLLLLLDVA 276
Query: 267 CPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTC 315
CP TC + + + FL L + N++++P+IY +++LR L ++ C
Sbjct: 277 CPAR-TCPVLLQ-ADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCC 323
>gi|223633986 trace amine associated receptor 5 [Homo sapiens]
Length = 337
Score = 77.4 bits (189), Expect = 2e-14
Identities = 78/289 (26%), Positives = 130/289 (44%), Gaps = 37/289 (12%)
Query: 50 LVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVAR 109
L+ ++ N V ++ + LH+P + LAL+D+ + G VL + I +E+
Sbjct: 46 LIIVLGNVFVAFAVSYFKALHTPTNFLLLSLALADMFL-GLLVLPLSTIRSVESCWFFGD 104
Query: 110 AAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIW 169
L +L +D + C + + LCF I++DR+ +I L Y S T+ A R + A W
Sbjct: 105 --FLCRLHTYLDTLFCLTSIFHLCF---ISIDRHCAICDPLLYPSKFTVRVALRYILAGW 159
Query: 170 VASVVFSTLFIAYYDHVAVLLC------------------------LVVFFLAMLVLMAV 205
+++LF+ Y D V L +FF+ L++++
Sbjct: 160 GVPAAYTSLFL-YTDVVETRLSQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMIS- 217
Query: 206 LYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIV 265
LYV + A + AQ I L K + K A TL I +GI+ LCW PF + T++
Sbjct: 218 LYVKIFVVATRQAQQITTLSKSLAGAAK-HERKAAKTLGIAVGIYLLCWLPFTID-TMVD 275
Query: 266 LCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLT 314
T + F++F+ N+ +P+IY F Q R+ LK L+
Sbjct: 276 SLLHFITPPLV---FDIFIWFAYFNSACNPIIYVFSYQWFRKALKLTLS 321
>gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens]
Length = 353
Score = 75.5 bits (184), Expect = 6e-14
Identities = 79/310 (25%), Positives = 139/310 (44%), Gaps = 50/310 (16%)
Query: 31 TGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGS 90
TG + L + + G F L + N+LV+A + KNR H P Y + LA +D +
Sbjct: 26 TGTK-LVIVLCVGTFFCLFI--FFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIA 82
Query: 91 NVLETAVILLLEAGALVARAAVLQQL--DNVIDVITCSSMLSSLCFLGAIAVDRYISIFY 148
V L+ G + V + ++D SS+ +SL L IAV+R++SI
Sbjct: 83 YVF-----LMFNTGPVSKTLTVNRWFLRQGLLD----SSLTASLTNLLVIAVERHMSIM- 132
Query: 149 ALRYHSIVTLPRARRAVAAIWVASVVF-----------------STLFIAYYDHVAVLLC 191
+R HS +T R + +W ++ S+L Y V
Sbjct: 133 RMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWT 192
Query: 192 L--VVFFLAMLVLMAVLYVHMLARA---CQHAQGIARLHKRQRPVHQGFGLKGAVTLTIL 246
+ ++ FL M+V+ +YV++ + H G + +R+ P +K T+ +
Sbjct: 193 VSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSG--SISRRRTP------MKLMKTVMTV 244
Query: 247 LGIFFLCWGPFFLHLTLIVL-CPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQEL 305
LG F +CW P + L L L C + CG FL L + N++++P+IY++ +++
Sbjct: 245 LGAFVVCWTPGLVVLLLDGLNCRQ---CGVQHVK-RWFLLLALLNSVVNPIIYSYKDEDM 300
Query: 306 RRTLKEVLTC 315
T+K+++ C
Sbjct: 301 YGTMKKMICC 310
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.333 0.142 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,209,767
Number of Sequences: 37866
Number of extensions: 386850
Number of successful extensions: 3566
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 516
Number of HSP's successfully gapped in prelim test: 211
Number of HSP's that attempted gapping in prelim test: 2016
Number of HSP's gapped (non-prelim): 1059
length of query: 317
length of database: 18,247,518
effective HSP length: 102
effective length of query: 215
effective length of database: 14,385,186
effective search space: 3092814990
effective search space used: 3092814990
T: 11
A: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 39 (21.5 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.