Guide to the Human Genome
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Search of human proteins with 190684694

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
         (1118 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]           2252   0.0  
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]           2252   0.0  
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]           2252   0.0  
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]   271   2e-72
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi...   271   2e-72
gi|45267835 ubiquitin specific protease 50 [Homo sapiens]             220   7e-57
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]             212   2e-54
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]             212   2e-54
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]            196   1e-49
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]                  195   2e-49
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]            190   7e-48
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]    189   1e-47
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]    189   1e-47
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]                  179   1e-44
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]                169   1e-41
gi|109638751 ubiquitin specific protease 6 [Homo sapiens]             167   4e-41
gi|22550104 ubiquitin specific protease 32 [Homo sapiens]             166   9e-41
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]        157   7e-38
gi|41152235 ubiquitin specific protease 51 [Homo sapiens]             153   1e-36
gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]                141   3e-33
gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens]                141   3e-33
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]   138   3e-32
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]   135   3e-31
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]   135   3e-31
gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens]                 133   8e-31
gi|148612811 ubiquitin specific protease 43 [Homo sapiens]            131   3e-30
gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sap...   130   7e-30
gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapi...   130   7e-30
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]           130   7e-30
gi|183396780 ubiquitin specific protease 20 [Homo sapiens]            130   9e-30

>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score = 2252 bits (5836), Expect = 0.0
 Identities = 1118/1118 (100%), Positives = 1118/1118 (100%)

Query: 1    MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAY 60
            MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAY
Sbjct: 1    MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAY 60

Query: 61   VLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRK 120
            VLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRK
Sbjct: 61   VLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRK 120

Query: 121  KLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK 180
            KLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK
Sbjct: 121  KLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK 180

Query: 181  GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLP 240
            GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLP
Sbjct: 181  GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLP 240

Query: 241  DDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGG 300
            DDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGG
Sbjct: 241  DDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGG 300

Query: 301  YENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDE 360
            YENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDE
Sbjct: 301  YENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDE 360

Query: 361  NIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEE 420
            NIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEE
Sbjct: 361  NIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEE 420

Query: 421  HRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEK 480
            HRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEK
Sbjct: 421  HRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEK 480

Query: 481  ELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKET 540
            ELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKET
Sbjct: 481  ELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKET 540

Query: 541  SAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSG 600
            SAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSG
Sbjct: 541  SAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSG 600

Query: 601  KPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLD 660
            KPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLD
Sbjct: 601  KPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLD 660

Query: 661  PITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSP 720
            PITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSP
Sbjct: 661  PITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSP 720

Query: 721  DITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR 780
            DITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR
Sbjct: 721  DITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR 780

Query: 781  NLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTG 840
            NLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTG
Sbjct: 781  NLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTG 840

Query: 841  QYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDH 900
            QYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDH
Sbjct: 841  QYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDH 900

Query: 901  LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTS 960
            LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTS
Sbjct: 901  LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTS 960

Query: 961  KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW 1020
            KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW
Sbjct: 961  KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW 1020

Query: 1021 KQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRW 1080
            KQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRW
Sbjct: 1021 KQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRW 1080

Query: 1081 FKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT 1118
            FKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT
Sbjct: 1081 FKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT 1118


>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score = 2252 bits (5836), Expect = 0.0
 Identities = 1118/1118 (100%), Positives = 1118/1118 (100%)

Query: 1    MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAY 60
            MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAY
Sbjct: 1    MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAY 60

Query: 61   VLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRK 120
            VLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRK
Sbjct: 61   VLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRK 120

Query: 121  KLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK 180
            KLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK
Sbjct: 121  KLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK 180

Query: 181  GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLP 240
            GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLP
Sbjct: 181  GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLP 240

Query: 241  DDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGG 300
            DDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGG
Sbjct: 241  DDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGG 300

Query: 301  YENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDE 360
            YENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDE
Sbjct: 301  YENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDE 360

Query: 361  NIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEE 420
            NIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEE
Sbjct: 361  NIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEE 420

Query: 421  HRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEK 480
            HRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEK
Sbjct: 421  HRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEK 480

Query: 481  ELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKET 540
            ELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKET
Sbjct: 481  ELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKET 540

Query: 541  SAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSG 600
            SAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSG
Sbjct: 541  SAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSG 600

Query: 601  KPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLD 660
            KPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLD
Sbjct: 601  KPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLD 660

Query: 661  PITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSP 720
            PITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSP
Sbjct: 661  PITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSP 720

Query: 721  DITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR 780
            DITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR
Sbjct: 721  DITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR 780

Query: 781  NLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTG 840
            NLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTG
Sbjct: 781  NLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTG 840

Query: 841  QYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDH 900
            QYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDH
Sbjct: 841  QYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDH 900

Query: 901  LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTS 960
            LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTS
Sbjct: 901  LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTS 960

Query: 961  KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW 1020
            KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW
Sbjct: 961  KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW 1020

Query: 1021 KQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRW 1080
            KQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRW
Sbjct: 1021 KQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRW 1080

Query: 1081 FKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT 1118
            FKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT
Sbjct: 1081 FKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT 1118


>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score = 2252 bits (5836), Expect = 0.0
 Identities = 1118/1118 (100%), Positives = 1118/1118 (100%)

Query: 1    MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAY 60
            MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAY
Sbjct: 1    MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAY 60

Query: 61   VLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRK 120
            VLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRK
Sbjct: 61   VLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRK 120

Query: 121  KLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK 180
            KLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK
Sbjct: 121  KLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK 180

Query: 181  GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLP 240
            GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLP
Sbjct: 181  GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLP 240

Query: 241  DDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGG 300
            DDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGG
Sbjct: 241  DDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGG 300

Query: 301  YENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDE 360
            YENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDE
Sbjct: 301  YENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDE 360

Query: 361  NIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEE 420
            NIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEE
Sbjct: 361  NIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEE 420

Query: 421  HRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEK 480
            HRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEK
Sbjct: 421  HRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEK 480

Query: 481  ELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKET 540
            ELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKET
Sbjct: 481  ELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKET 540

Query: 541  SAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSG 600
            SAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSG
Sbjct: 541  SAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSG 600

Query: 601  KPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLD 660
            KPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLD
Sbjct: 601  KPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLD 660

Query: 661  PITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSP 720
            PITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSP
Sbjct: 661  PITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSP 720

Query: 721  DITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR 780
            DITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR
Sbjct: 721  DITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR 780

Query: 781  NLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTG 840
            NLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTG
Sbjct: 781  NLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTG 840

Query: 841  QYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDH 900
            QYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDH
Sbjct: 841  QYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDH 900

Query: 901  LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTS 960
            LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTS
Sbjct: 901  LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTS 960

Query: 961  KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW 1020
            KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW
Sbjct: 961  KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW 1020

Query: 1021 KQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRW 1080
            KQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRW
Sbjct: 1021 KQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRW 1080

Query: 1081 FKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT 1118
            FKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT
Sbjct: 1081 FKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT 1118


>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
          Length = 396

 Score =  271 bits (694), Expect = 2e-72
 Identities = 144/343 (41%), Positives = 200/343 (58%), Gaps = 6/343 (1%)

Query: 772  SGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFG 831
            S   L GLRNLGNTC+MNSILQCL N   L DY  +  Y  D++  +       + EEF 
Sbjct: 53   SAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGS--NAHTALVEEFA 110

Query: 832  IIMKALWTGQYR-YISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNR 890
             +++ +WT      +SP +FK  I +   +F GY+QQD+QE L FL+DGLH ++N+   R
Sbjct: 111  KLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLR 170

Query: 891  KRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 950
             +   EN DHL D +     W+K+ +  +S I  LF GQ KS++ C  C   S  F+ F 
Sbjct: 171  PKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFW 230

Query: 951  YLSLPLASTS--KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLL 1008
             LSLP+A     + TL DC+RLF+KE+ L  + +  C  CR R+  +KK  I + P +L+
Sbjct: 231  DLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILV 290

Query: 1009 VHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHY 1068
            +HLKRFS       KL T V+FPL +LDL ++      N   YNL++VSNH G   GGHY
Sbjct: 291  LHLKRFSESRIRTSKLTTFVNFPLRDLDLREFA-SENTNHAVYNLYAVSNHSGTTMGGHY 349

Query: 1069 TAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGP 1111
            TAYC++     W  F+D  V+ +S S V++S AY+LFY    P
Sbjct: 350  TAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASP 392


>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapiens]
          Length = 605

 Score =  271 bits (694), Expect = 2e-72
 Identities = 144/343 (41%), Positives = 200/343 (58%), Gaps = 6/343 (1%)

Query: 772  SGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFG 831
            S   L GLRNLGNTC+MNSILQCL N   L DY  +  Y  D++  +       + EEF 
Sbjct: 262  SAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGS--NAHTALVEEFA 319

Query: 832  IIMKALWTGQYR-YISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNR 890
             +++ +WT      +SP +FK  I +   +F GY+QQD+QE L FL+DGLH ++N+   R
Sbjct: 320  KLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLR 379

Query: 891  KRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 950
             +   EN DHL D +     W+K+ +  +S I  LF GQ KS++ C  C   S  F+ F 
Sbjct: 380  PKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFW 439

Query: 951  YLSLPLASTS--KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLL 1008
             LSLP+A     + TL DC+RLF+KE+ L  + +  C  CR R+  +KK  I + P +L+
Sbjct: 440  DLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILV 499

Query: 1009 VHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHY 1068
            +HLKRFS       KL T V+FPL +LDL ++      N   YNL++VSNH G   GGHY
Sbjct: 500  LHLKRFSESRIRTSKLTTFVNFPLRDLDLREFA-SENTNHAVYNLYAVSNHSGTTMGGHY 558

Query: 1069 TAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGP 1111
            TAYC++     W  F+D  V+ +S S V++S AY+LFY    P
Sbjct: 559  TAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASP 601


>gi|45267835 ubiquitin specific protease 50 [Homo sapiens]
          Length = 339

 Score =  220 bits (560), Expect = 7e-57
 Identities = 115/303 (37%), Positives = 168/303 (55%), Gaps = 7/303 (2%)

Query: 776  LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
            +TGL NLGNTC +N+I QCLC+   L +YF    Y   + +  L     EVA  F  +M 
Sbjct: 43   VTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLPSDCSEVATAFAYLMT 102

Query: 836  ALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKE 895
             +W G    +SP+ F   +G +   F    QQD+QE L+ +++ LHE L K    +R   
Sbjct: 103  DMWLGDSDCVSPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKYHYSRRRSY 162

Query: 896  ENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLP 955
            E         + +   +K      SII  LF+ Q   ++ CL C K +   E F   SLP
Sbjct: 163  EKG-------STQRCCRKWITTETSIITQLFEEQLNYSIVCLKCEKCTYKNEVFTVFSLP 215

Query: 956  LASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFS 1015
            + S  +C+L+DCL+ F +++ LT NN  +CS C  ++++  +  I K P +++ HLKRF 
Sbjct: 216  IPSKYECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFD 275

Query: 1016 YDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNA 1075
              G  K+KL+T + +PL NLDL+ Y+        KYNL +V NH+G LDGGHYTA+CKN+
Sbjct: 276  IQGTTKRKLRTDIHYPLTNLDLTPYICSIFRKYPKYNLCAVVNHFGDLDGGHYTAFCKNS 335

Query: 1076 ARQ 1078
              Q
Sbjct: 336  VTQ 338


>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score =  212 bits (539), Expect = 2e-54
 Identities = 125/354 (35%), Positives = 181/354 (51%), Gaps = 26/354 (7%)

Query: 773  GPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGI 832
            G    GLRNLGNTC++N++LQCL +   L D+  R  ++ ++      G   E+ E F  
Sbjct: 208  GSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFAD 264

Query: 833  IMKALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRK 891
            ++ ALW       ++P  F+    K    F+GYSQQD+QE L  LM+ LH ++N+   R 
Sbjct: 265  VIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRA 324

Query: 892  RYKEENND---------------HLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQC 936
                 N                  L D   A   W+++ +  +S IV LF GQ KS ++C
Sbjct: 325  PPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKC 384

Query: 937  LTCHKKSRTFEAFMYLSLPLASTS----KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR 992
              C  +S TFE F  LSLP+        K +L+DC  LF+KEE+L   N   C  CR + 
Sbjct: 385  QACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKT 444

Query: 993  DSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYN 1052
             S KK+ + + P +L++HL RFS      +K    VDFPL+ L L  +    K     Y 
Sbjct: 445  RSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFA-SDKAGSPVYQ 503

Query: 1053 LFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106
            L+++ NH G +  GHYTA C+   +  W  ++D  VS +S + V SS  Y+LFY
Sbjct: 504  LYALCNHSGSVHYGHYTALCR--CQTGWHVYNDSRVSPVSENQVASSEGYVLFY 555


>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score =  212 bits (539), Expect = 2e-54
 Identities = 125/354 (35%), Positives = 181/354 (51%), Gaps = 26/354 (7%)

Query: 773  GPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGI 832
            G    GLRNLGNTC++N++LQCL +   L D+  R  ++ ++      G   E+ E F  
Sbjct: 208  GSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFAD 264

Query: 833  IMKALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRK 891
            ++ ALW       ++P  F+    K    F+GYSQQD+QE L  LM+ LH ++N+   R 
Sbjct: 265  VIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRA 324

Query: 892  RYKEENND---------------HLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQC 936
                 N                  L D   A   W+++ +  +S IV LF GQ KS ++C
Sbjct: 325  PPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKC 384

Query: 937  LTCHKKSRTFEAFMYLSLPLASTS----KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR 992
              C  +S TFE F  LSLP+        K +L+DC  LF+KEE+L   N   C  CR + 
Sbjct: 385  QACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKT 444

Query: 993  DSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYN 1052
             S KK+ + + P +L++HL RFS      +K    VDFPL+ L L  +    K     Y 
Sbjct: 445  RSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFA-SDKAGSPVYQ 503

Query: 1053 LFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106
            L+++ NH G +  GHYTA C+   +  W  ++D  VS +S + V SS  Y+LFY
Sbjct: 504  LYALCNHSGSVHYGHYTALCR--CQTGWHVYNDSRVSPVSENQVASSEGYVLFY 555


>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
          Length = 952

 Score =  196 bits (498), Expect = 1e-49
 Identities = 100/239 (41%), Positives = 142/239 (59%), Gaps = 4/239 (1%)

Query: 727 QEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTC 786
           + E+   P    T N +N   C P    S  +        P      P L GL NLGNTC
Sbjct: 214 KNEDGTWPRGPSTPNVKNSNYCLP----SYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTC 269

Query: 787 YMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYIS 846
           +MNS +QCL N P L +YF  + YQ+++N  N LG +GE+A+ +  ++K +W+G++ Y++
Sbjct: 270 FMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVT 329

Query: 847 PKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKA 906
           P+ FK  +G+   QF+GY QQD QELL FL+DGLHEDLN+   +   + ++ D   D   
Sbjct: 330 PRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVV 389

Query: 907 AEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQ 965
           AE AW+ H + N+SIIV +F G FKST+ C  C K S TF+ F YL+LPL    + TL+
Sbjct: 390 AEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLE 448



 Score =  162 bits (411), Expect = 1e-39
 Identities = 71/143 (49%), Positives = 100/143 (69%)

Query: 964  LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023
            L+DC+ LF+ +EKL   + +YC +C+  + + KK+++W LPPVL+VHLKRFSY    + K
Sbjct: 759  LKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDK 818

Query: 1024 LQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083
            L T VDFP+ +LD+S+++I P     +YNL +VSNHYGG+ GGHYTA+ KN    +W+ F
Sbjct: 819  LDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYF 878

Query: 1084 DDHEVSDISVSSVKSSAAYILFY 1106
            DD  VS  S   + S AAY+LFY
Sbjct: 879  DDSSVSTASEDQIVSKAAYVLFY 901


>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
          Length = 520

 Score =  195 bits (496), Expect = 2e-49
 Identities = 126/363 (34%), Positives = 181/363 (49%), Gaps = 46/363 (12%)

Query: 777  TGLRNLGNTCYMNSILQCLCNAPHLADYFN--------------RNCYQDDINRSNLLGH 822
            TGLRNLGNTC+MN+ILQ L N      YF               R  Y       N +  
Sbjct: 159  TGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVS- 217

Query: 823  KGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHE 882
               + EEF   + ALW G     SP+     + KI   F GY QQD+ E + +L+D LH 
Sbjct: 218  ---LVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHL 274

Query: 883  DLNKADN---RKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTC 939
            +L    N   R    +EN+      K   +          +++ A+F G  ++ V CL C
Sbjct: 275  ELQGGFNGVSRSAILQENSTLSASNKCCING-------ASTVVTAIFGGILQNEVNCLIC 327

Query: 940  HKKSRTFEAFMYLSLPLASTSK------------CTLQDCLRLFSKEEKLTDNNRFYCSH 987
              +SR F+ F+ LSL + S  +            C+L+DCLR F+  E+L +   + C  
Sbjct: 328  GTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHK 387

Query: 988  CRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNN 1047
            C+ ++ S KK  I KLP VL +HLKRF +    + K+ T V+FPL  LD+  Y++ P+N+
Sbjct: 388  CKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGLDMKCYLLEPENS 447

Query: 1048 LKK---YNLFSVSNHYG-GLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYI 1103
              +   Y+L +V  H+G G+  GHYTAY  +    RWF F+D  V+     +V  + AYI
Sbjct: 448  GPESCLYDLAAVVVHHGSGVGSGHYTAYATHEG--RWFHFNDSTVTLTDEETVVKAKAYI 505

Query: 1104 LFY 1106
            LFY
Sbjct: 506  LFY 508


>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
          Length = 963

 Score =  190 bits (482), Expect = 7e-48
 Identities = 93/192 (48%), Positives = 122/192 (63%)

Query: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGII 833
           P + GL NLGNTC+MNS LQCL N P L +YF  NCY +++N  N LG KGE+AE +  +
Sbjct: 306 PGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADL 365

Query: 834 MKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRY 893
           +K  W+G +R I P  FK  +G    QF GY Q DSQELL FL+DGLHEDLN+   ++  
Sbjct: 366 VKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYV 425

Query: 894 KEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLS 953
           +  +     D + A+ AWQ HK+ N+S+IV  F G FKST+ C  C   S TF+ F YLS
Sbjct: 426 ELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLS 485

Query: 954 LPLASTSKCTLQ 965
           +PL  + K  L+
Sbjct: 486 VPLPISHKRVLE 497



 Score =  146 bits (369), Expect = 9e-35
 Identities = 66/147 (44%), Positives = 99/147 (67%), Gaps = 4/147 (2%)

Query: 964  LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023
            LQ+C+ LF+  E L   N +YC  C+  + + KK+++W LP +L++HLKRFSY    ++K
Sbjct: 781  LQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREK 840

Query: 1024 LQTSVDFPLENLDLSQYVIGPKN----NLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQR 1079
            L T V+FP+ +LD S++VI P+N     L KY+L +VSNHYGG+  GHYT +  N    +
Sbjct: 841  LDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQ 900

Query: 1080 WFKFDDHEVSDISVSSVKSSAAYILFY 1106
            W  FDD+ VS ++ + ++S AAY+LFY
Sbjct: 901  WHYFDDNSVSPVNENQIESKAAYVLFY 927


>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
          Length = 963

 Score =  189 bits (480), Expect = 1e-47
 Identities = 90/183 (49%), Positives = 124/183 (67%)

Query: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGII 833
           P L GL NLGNTC+MNS LQCL N   L DYF ++ Y+ +INR N LG KGE+AE +  +
Sbjct: 299 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 358

Query: 834 MKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRY 893
           +K +W+G+  +++P+ FK  +G+   QF+GY QQDSQELL FL+DGLHEDLN+   +   
Sbjct: 359 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418

Query: 894 KEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLS 953
           + ++ +   D   A+ AW+ H+  N+S+IV  F G FKST+ C  C K S TF+ F YL+
Sbjct: 419 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 478

Query: 954 LPL 956
           LPL
Sbjct: 479 LPL 481



 Score =  145 bits (365), Expect = 3e-34
 Identities = 63/143 (44%), Positives = 94/143 (65%)

Query: 964  LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023
            L+DC+ LF+  E L +++ +YC +C+  + + KK ++W LP +L+VHLKRFSY+  W+ K
Sbjct: 778  LRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDK 837

Query: 1024 LQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083
            L T V+FP+  L++S++V         Y+L +VSNHYG +  GHYTAY KN    +W+ F
Sbjct: 838  LDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYF 897

Query: 1084 DDHEVSDISVSSVKSSAAYILFY 1106
            DD  VS  S   + + AAY+LFY
Sbjct: 898  DDSNVSLASEDQIVTKAAYVLFY 920


>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
          Length = 916

 Score =  189 bits (480), Expect = 1e-47
 Identities = 90/183 (49%), Positives = 124/183 (67%)

Query: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGII 833
           P L GL NLGNTC+MNS LQCL N   L DYF ++ Y+ +INR N LG KGE+AE +  +
Sbjct: 252 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 311

Query: 834 MKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRY 893
           +K +W+G+  +++P+ FK  +G+   QF+GY QQDSQELL FL+DGLHEDLN+   +   
Sbjct: 312 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371

Query: 894 KEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLS 953
           + ++ +   D   A+ AW+ H+  N+S+IV  F G FKST+ C  C K S TF+ F YL+
Sbjct: 372 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 431

Query: 954 LPL 956
           LPL
Sbjct: 432 LPL 434



 Score =  145 bits (365), Expect = 3e-34
 Identities = 63/143 (44%), Positives = 94/143 (65%)

Query: 964  LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023
            L+DC+ LF+  E L +++ +YC +C+  + + KK ++W LP +L+VHLKRFSY+  W+ K
Sbjct: 731  LRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDK 790

Query: 1024 LQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083
            L T V+FP+  L++S++V         Y+L +VSNHYG +  GHYTAY KN    +W+ F
Sbjct: 791  LDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYF 850

Query: 1084 DDHEVSDISVSSVKSSAAYILFY 1106
            DD  VS  S   + + AAY+LFY
Sbjct: 851  DDSNVSLASEDQIVTKAAYVLFY 873


>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
          Length = 1318

 Score =  179 bits (455), Expect = 1e-44
 Identities = 108/280 (38%), Positives = 144/280 (51%), Gaps = 13/280 (4%)

Query: 691 STPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPT--VTP---TVNRENK 745
           STPP     P    E  R   K K    S D    +     R P   VTP   T     K
Sbjct: 406 STPPGGAPHPLTGQEEARAVEKDKSKARSEDT--GLDSVATRTPMEHVTPKPETHLASPK 463

Query: 746 PTCY----PKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHL 801
           PTC     P + +S  S  +            P  TGL NLGNTC+MNS++Q L N   L
Sbjct: 464 PTCMVPPMPHSPVSGDSVEEEEEEEKKV--CLPGFTGLVNLGNTCFMNSVIQSLSNTREL 521

Query: 802 ADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQF 861
            D+F+   ++ +IN +N LG  G +A  F ++++ALW G +    P   K  +     QF
Sbjct: 522 RDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQF 581

Query: 862 AGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESI 921
            GY+Q D+QE + FL+DGLHEDLN+  N+   +  ++D   D   AE AWQ+HK  N+S 
Sbjct: 582 TGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSF 641

Query: 922 IVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSK 961
           IV LFQGQ+KS + C  C K S TF+ F+YL +PL    K
Sbjct: 642 IVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQK 681



 Score =  131 bits (330), Expect = 3e-30
 Identities = 81/232 (34%), Positives = 123/232 (53%), Gaps = 28/232 (12%)

Query: 887  ADNRKRYKEENND---HLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKS 943
            + NR++  E+  D    L D  +    W+ +++L E ++VA         ++C       
Sbjct: 996  SSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVA------SKELEC--AEDPG 1047

Query: 944  RTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKL 1003
               EA        A     TL  CL LF++ E L     +YC  C+  R++ K++ +W+L
Sbjct: 1048 SAGEA--------ARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRL 1099

Query: 1004 PPVLLVHLKRFSYDG-RWKQKLQTSVDFPLENLDLSQYVIGPK-NNLKKYNLFSVSNHYG 1061
            P VL+V LKRFS+    W+ K+   V+FP+ NLDLS++ IG K   L  Y+L++V NHYG
Sbjct: 1100 PNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYG 1159

Query: 1062 GLDGGHYTAYCK---NAARQR----WFKFDDHEVSDISVSSVKSSAAYILFY 1106
            G+ GGHYTA  +   + + QR    W  FDD  V+ +  S V +  AY+LFY
Sbjct: 1160 GMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFY 1211


>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
          Length = 525

 Score =  169 bits (429), Expect = 1e-41
 Identities = 126/421 (29%), Positives = 186/421 (44%), Gaps = 66/421 (15%)

Query: 724  QAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLG 783
            + I +EE+RK      V  +       K E+  L  +  R    +       L GL NLG
Sbjct: 125  EIIAKEEQRKAWKMQGVGEKFSTWEPTKRELELLKHNPKRR--KITSNCTIGLRGLINLG 182

Query: 784  NTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYR 843
            NTC+MN I+Q L + P L D+F       D +R  +      +  E   + +  ++G   
Sbjct: 183  NTCFMNCIVQALTHTPLLRDFF-----LSDRHRCEMQSPSSCLVCEMSSLFQEFYSGHRS 237

Query: 844  YISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDD 903
               P      +       AGY QQD+ E L+  +D LH      DN K  K  N +H + 
Sbjct: 238  PHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCKGDDNGK--KANNPNHCN- 294

Query: 904  FKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSK-- 961
                             II  +F G  +S V C  CH  S T + F  +SL L  +S   
Sbjct: 295  ----------------CIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGSSTPF 338

Query: 962  ---------------------CTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEI 1000
                                  TL DCLR F++ E L  + +  CS C + ++S K++ +
Sbjct: 339  WPLSPGSEGNVVNGESHVSGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTM 398

Query: 1001 WKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPK--------------- 1045
             KLP V   HLKRF +  + ++K+ T V FPLE LD++ ++   K               
Sbjct: 399  KKLPIVACFHLKRFEHSAKLRRKITTYVSFPLE-LDMTPFMASSKESRMNGQYQQPTDSL 457

Query: 1046 NNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILF 1105
            NN  KY+LF+V NH G L+ GHYT++ +   + +WFK DD  ++  S+  V  S  Y+LF
Sbjct: 458  NNDNKYSLFAVVNHQGTLESGHYTSFIRQ-HKDQWFKCDDAIITKASIKDVLDSEGYLLF 516

Query: 1106 Y 1106
            Y
Sbjct: 517  Y 517


>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
          Length = 1406

 Score =  167 bits (424), Expect = 4e-41
 Identities = 91/223 (40%), Positives = 133/223 (59%), Gaps = 5/223 (2%)

Query: 744 NKPTCYPKAEISRLSASQI-RNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLA 802
           NK   +P+      ++S+I R   P   G+    TGL NLGNTC+MNS +QC+ N   L 
Sbjct: 502 NKDMSWPEEMSFTANSSKIDRQKVPTEKGA----TGLSNLGNTCFMNSSIQCVSNTQPLT 557

Query: 803 DYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFA 862
            YF    +  ++NR+N +G KG +A+ +G +++ LW+G  + ++P   + TI K   +F 
Sbjct: 558 QYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFD 617

Query: 863 GYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESII 922
           G+ QQDSQELL FL+DGLHEDLN+   +   + +++D   D++ A  AW  H + N SII
Sbjct: 618 GFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSII 677

Query: 923 VALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQ 965
           V LF GQ +S V+C TC   S  F+ F +LSLPL   S   L+
Sbjct: 678 VDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLE 720



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 32/86 (37%), Positives = 50/86 (58%)

Query: 957  ASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSY 1016
            A      L  CLR F+ EE+L ++  +YCS C+    + KK+++W+LPP L++HLKRF +
Sbjct: 1026 AQAEPINLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQF 1085

Query: 1017 DGRWKQKLQTSVDFPLENLDLSQYVI 1042
                  K Q  V F  E+ D S +++
Sbjct: 1086 VNDQWIKSQKIVRFLRESFDPSAFLV 1111



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 23/60 (38%), Positives = 35/60 (58%), Gaps = 1/60 (1%)

Query: 1051 YNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLG 1110
            YNL+++S H G L GGHY  Y KN    +W+ ++D    ++    + + +AYILFY   G
Sbjct: 1312 YNLYAISCHSGILSGGHYITYAKN-PNCKWYCYNDSSCEELHPDEIDTDSAYILFYEQQG 1370


>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
          Length = 1604

 Score =  166 bits (421), Expect = 9e-41
 Identities = 90/223 (40%), Positives = 134/223 (60%), Gaps = 5/223 (2%)

Query: 744 NKPTCYPKAEISRLSASQI-RNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLA 802
           NK   +P+      ++S+I R+  P   G+    TGL NLGNTC+MNS +QC+ N   L 
Sbjct: 704 NKDMSWPEEMSFIANSSKIDRHKVPTEKGA----TGLSNLGNTCFMNSSIQCVSNTQPLT 759

Query: 803 DYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFA 862
            YF    +  ++NR+N +G KG +A+ +G +++ LW+G  + ++P   + TI K   +F 
Sbjct: 760 QYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFN 819

Query: 863 GYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESII 922
           G+ QQDSQELL FL+DGLHEDLN+   +   + +++D   D++ A  AW  H + N SI+
Sbjct: 820 GFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIV 879

Query: 923 VALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQ 965
           V LF GQ +S V+C TC   S  F+ F +LSLPL   S   L+
Sbjct: 880 VDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLE 922



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 37/87 (42%), Positives = 56/87 (64%), Gaps = 2/87 (2%)

Query: 957  ASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSY 1016
            A      L  CLR F+ EE+L +N  +YCS C+    + KK+++W+LPP+L++HLKRF +
Sbjct: 1228 AQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQF 1287

Query: 1017 -DGRWKQKLQTSVDFPLENLDLSQYVI 1042
             +GRW  K Q  V FP E+ D S +++
Sbjct: 1288 VNGRW-IKSQKIVKFPRESFDPSAFLV 1313



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 23/60 (38%), Positives = 35/60 (58%), Gaps = 1/60 (1%)

Query: 1051 YNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLG 1110
            YNL+++S H G L GGHY  Y KN    +W+ ++D    ++    + + +AYILFY   G
Sbjct: 1510 YNLYAISCHSGILGGGHYVTYAKN-PNCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQG 1568


>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
          Length = 438

 Score =  157 bits (396), Expect = 7e-38
 Identities = 111/373 (29%), Positives = 172/373 (46%), Gaps = 73/373 (19%)

Query: 776  LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
            L GL NLGNTC+MN I+Q L + P L D+F  + ++ ++    L      +  E   + +
Sbjct: 77   LRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELC-----LVCEMSSLFR 131

Query: 836  ALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLH-----EDLNKADNR 890
             L++G      P      +       AGY QQD+ E L+  +D LH     +D+ KA N 
Sbjct: 132  ELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAAN- 190

Query: 891  KRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 950
                  N +H +                  II  +F G  +S V C  CH  S T +   
Sbjct: 191  ------NPNHCN-----------------CIIDQIFTGGLQSDVTCQACHGVSTTIDPCW 227

Query: 951  YLSLPLASTSKC----------------------TLQDCLRLFSKEEKLTDNNRFYCSHC 988
             +SL L  +                         TL DCLR F++ E L  + +  C  C
Sbjct: 228  DISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSC 287

Query: 989  RARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPK--- 1045
            ++ ++S K++ + KLP V   H KRF +  + ++K+ T + FPLE LD++ ++   K   
Sbjct: 288  QSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLE-LDMTPFMASSKESR 346

Query: 1046 ------------NNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISV 1093
                        NN  KY+LF+V NH G L+ GHYT++ ++  + +WFK DD  ++  S+
Sbjct: 347  MNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRH-HKDQWFKCDDAVITKASI 405

Query: 1094 SSVKSSAAYILFY 1106
              V  S  Y+LFY
Sbjct: 406  KDVLDSEGYLLFY 418


>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
          Length = 711

 Score =  153 bits (386), Expect = 1e-36
 Identities = 106/372 (28%), Positives = 171/372 (45%), Gaps = 63/372 (16%)

Query: 776  LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
            L GL NLGNTC+MN I+Q L + P L D+F  + ++  +   +L      +  E   +  
Sbjct: 362  LRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLC-----LVCEMSSLFH 416

Query: 836  ALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKE 895
            A+++G      P      I    +  AGY QQD+ E L+ ++D LH              
Sbjct: 417  AMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHR------------- 463

Query: 896  ENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLP 955
                H  D    + A   +      II  +F G  +S V C  CH  S T +    +SL 
Sbjct: 464  ----HSKDDSGGQEA--NNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLD 517

Query: 956  LASTSKC-----------------------TLQDCLRLFSKEEKLTDNNRFYCSHCRARR 992
            L  +                          +L DCL+ F++ E L  + +  C+ C++ +
Sbjct: 518  LPGSCATFDSQNPERADSTVSRDDHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQ 577

Query: 993  DSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKN------ 1046
            +S K++ + KLP V   HLKRF + G+ ++K+ T + FPLE LD++ ++   K       
Sbjct: 578  ESTKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLE-LDMTPFLASTKESRMKEG 636

Query: 1047 --------NLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKS 1098
                    N  KY+LF+V NH+G L+ GHYT++ +   + +WF  DD  ++  ++  +  
Sbjct: 637  QPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIRQ-QKDQWFSCDDAIITKATIEDLLY 695

Query: 1099 SAAYILFYTSLG 1110
            S  Y+LFY   G
Sbjct: 696  SEGYLLFYHKQG 707


>gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]
          Length = 712

 Score =  141 bits (356), Expect = 3e-33
 Identities = 137/504 (27%), Positives = 209/504 (41%), Gaps = 111/504 (22%)

Query: 701  QIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSAS 760
            Q+ AE +  P +          +  I+    + P  TP    ++K     + EIS+  + 
Sbjct: 200  QVKAELESMPPRKSLRLQGLAQSTIIEIVSVQVPAQTPASPAKDKVLSTSENEISQKVSD 259

Query: 761  QIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCL------------------------- 795
                  P+     P +TGLRNLGNTCYMNS+LQ L                         
Sbjct: 260  SSVKRRPIVT---PGVTGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKLDLNQWLAMTASE 316

Query: 796  ----CNAPHLAD---YFNRNCYQDDI----NRSNLL----------GHKGEVAE------ 828
                C  P + D   Y    C + D     +R + L          G K E+ +      
Sbjct: 317  KTRSCKHPPVTDTVVYQMNECQEKDTGFVCSRQSSLSSGLSGGASKGRKMELIQPKEPTS 376

Query: 829  -------EFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLH 881
                   E   + + +W+G++  +SP     ++ ++   F GY+QQD+QE L  L+D + 
Sbjct: 377  QYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQ 436

Query: 882  EDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHK 941
             +L          E     L             + LN  ++  +F GQ  S V CL C  
Sbjct: 437  REL----------ETTGTSLPALIPTSQRKLIKQVLN--VVNNIFHGQLLSQVTCLACDN 484

Query: 942  KSRTFEAFMYLSLPLASTSKCTLQDC----------LRLFSKEEKLTDNNRFYCSHCRAR 991
            KS T E F  LSL      +C+ +D           L  F++ E L +   + C  C ++
Sbjct: 485  KSNTIEPFWDLSLEFPERYQCSGKDIASQPCLVTEMLAKFTETEAL-EGKIYVCDQCNSK 543

Query: 992  R-----------DSLKKIEIWKLPPVLLVHLKRFSYDGRW-KQKLQTSVDFPLENLDLSQ 1039
            R           ++ K++ I  LP VL +HLKRF + GR  ++K+   V F  E L++  
Sbjct: 544  RRRFSSKPVVLTEAQKQLMICHLPQVLRLHLKRFRWSGRNNREKIGVHVGFE-EILNMEP 602

Query: 1040 YVIGPKNNLKK-------YNLFSVSNHYG-GLDGGHYTAYCKNAARQRWFKFDDHEVSDI 1091
            Y    +  LK        Y+L +V  H+G G   GHYTAYC N+    W   +D ++S  
Sbjct: 603  YCC--RETLKSLRPECFIYDLSAVVMHHGKGFGSGHYTAYCYNSEGGFWVHCNDSKLSMC 660

Query: 1092 SVSSVKSSAAYILFYTSLGPRVTD 1115
            ++  V  + AYILFYT    RVT+
Sbjct: 661  TMDEVCKAQAYILFYTQ---RVTE 681


>gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens]
          Length = 712

 Score =  141 bits (356), Expect = 3e-33
 Identities = 137/504 (27%), Positives = 209/504 (41%), Gaps = 111/504 (22%)

Query: 701  QIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSAS 760
            Q+ AE +  P +          +  I+    + P  TP    ++K     + EIS+  + 
Sbjct: 200  QVKAELESMPPRKSLRLQGLAQSTIIEIVSVQVPAQTPASPAKDKVLSTSENEISQKVSD 259

Query: 761  QIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCL------------------------- 795
                  P+     P +TGLRNLGNTCYMNS+LQ L                         
Sbjct: 260  SSVKRRPIVT---PGVTGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKLDLNQWLAMTASE 316

Query: 796  ----CNAPHLAD---YFNRNCYQDDI----NRSNLL----------GHKGEVAE------ 828
                C  P + D   Y    C + D     +R + L          G K E+ +      
Sbjct: 317  KTRSCKHPPVTDTVVYQMNECQEKDTGFVCSRQSSLSSGLSGGASKGRKMELIQPKEPTS 376

Query: 829  -------EFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLH 881
                   E   + + +W+G++  +SP     ++ ++   F GY+QQD+QE L  L+D + 
Sbjct: 377  QYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQ 436

Query: 882  EDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHK 941
             +L          E     L             + LN  ++  +F GQ  S V CL C  
Sbjct: 437  REL----------ETTGTSLPALIPTSQRKLIKQVLN--VVNNIFHGQLLSQVTCLACDN 484

Query: 942  KSRTFEAFMYLSLPLASTSKCTLQDC----------LRLFSKEEKLTDNNRFYCSHCRAR 991
            KS T E F  LSL      +C+ +D           L  F++ E L +   + C  C ++
Sbjct: 485  KSNTIEPFWDLSLEFPERYQCSGKDIASQPCLVTEMLAKFTETEAL-EGKIYVCDQCNSK 543

Query: 992  R-----------DSLKKIEIWKLPPVLLVHLKRFSYDGRW-KQKLQTSVDFPLENLDLSQ 1039
            R           ++ K++ I  LP VL +HLKRF + GR  ++K+   V F  E L++  
Sbjct: 544  RRRFSSKPVVLTEAQKQLMICHLPQVLRLHLKRFRWSGRNNREKIGVHVGFE-EILNMEP 602

Query: 1040 YVIGPKNNLKK-------YNLFSVSNHYG-GLDGGHYTAYCKNAARQRWFKFDDHEVSDI 1091
            Y    +  LK        Y+L +V  H+G G   GHYTAYC N+    W   +D ++S  
Sbjct: 603  YCC--RETLKSLRPECFIYDLSAVVMHHGKGFGSGHYTAYCYNSEGGFWVHCNDSKLSMC 660

Query: 1092 SVSSVKSSAAYILFYTSLGPRVTD 1115
            ++  V  + AYILFYT    RVT+
Sbjct: 661  TMDEVCKAQAYILFYTQ---RVTE 681


>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
          Length = 828

 Score =  138 bits (347), Expect = 3e-32
 Identities = 81/250 (32%), Positives = 121/250 (48%), Gaps = 48/250 (19%)

Query: 905  KAAEHAWQKHKQLNE---SIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPL----- 956
            K A+ A  K K+ ++   S+I  +F G   S+VQCLTC + S T E F  LSLP+     
Sbjct: 455  KKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514

Query: 957  -------------ASTSKC--------------------------TLQDCLRLFSKEEKL 977
                              C                          TLQDCL  F   ++L
Sbjct: 515  LAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDEL 574

Query: 978  TDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDL 1037
              +N + C  C+  R+ +K  ++   P +L +HLKRF ++  +  K+ T V FPLE LDL
Sbjct: 575  KGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDL 634

Query: 1038 SQYVI-GPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSV 1096
              ++       +  Y+L SV  H+G    GHY AYC+N     W++FDD  V+++S S+V
Sbjct: 635  QPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTV 694

Query: 1097 KSSAAYILFY 1106
            +++ AY+LFY
Sbjct: 695  QNAEAYVLFY 704



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 44/112 (39%), Positives = 58/112 (51%), Gaps = 7/112 (6%)

Query: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
           LTGL+N+GNTCYMN+ LQ L N P L  +F       D         K  + + +  +M 
Sbjct: 184 LTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSYLKLMT 237

Query: 836 ALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNK 886
            LW   +   + P      I  +N  F GYSQQD+QE L  LMD LHE+L +
Sbjct: 238 ELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE 289


>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
          Length = 942

 Score =  135 bits (339), Expect = 3e-31
 Identities = 81/258 (31%), Positives = 121/258 (46%), Gaps = 56/258 (21%)

Query: 905  KAAEHAWQKHKQLNE---SIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLP------ 955
            K A+ A  K K+ ++   S+I  +F G   S+VQCLTC + S T E F  LSLP      
Sbjct: 455  KKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514

Query: 956  ------------LASTSKC----------------------------------TLQDCLR 969
                        +     C                                  TLQDCL 
Sbjct: 515  LAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLA 574

Query: 970  LFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVD 1029
             F   ++L  +N + C  C+  R+ +K  ++   P +L +HLKRF ++  +  K+ T V 
Sbjct: 575  AFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVS 634

Query: 1030 FPLENLDLSQYVI-GPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEV 1088
            FPLE LDL  ++       +  Y+L SV  H+G    GHY AYC+N     W++FDD  V
Sbjct: 635  FPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSV 694

Query: 1089 SDISVSSVKSSAAYILFY 1106
            +++S S+V+++ AY+LFY
Sbjct: 695  TEVSESTVQNAEAYVLFY 712



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 44/112 (39%), Positives = 58/112 (51%), Gaps = 7/112 (6%)

Query: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
           LTGL+N+GNTCYMN+ LQ L N P L  +F       D         K  + + +  +M 
Sbjct: 184 LTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSYLKLMT 237

Query: 836 ALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNK 886
            LW   +   + P      I  +N  F GYSQQD+QE L  LMD LHE+L +
Sbjct: 238 ELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE 289


>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
          Length = 911

 Score =  135 bits (339), Expect = 3e-31
 Identities = 81/258 (31%), Positives = 121/258 (46%), Gaps = 56/258 (21%)

Query: 905  KAAEHAWQKHKQLNE---SIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLP------ 955
            K A+ A  K K+ ++   S+I  +F G   S+VQCLTC + S T E F  LSLP      
Sbjct: 424  KKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 483

Query: 956  ------------LASTSKC----------------------------------TLQDCLR 969
                        +     C                                  TLQDCL 
Sbjct: 484  LAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLA 543

Query: 970  LFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVD 1029
             F   ++L  +N + C  C+  R+ +K  ++   P +L +HLKRF ++  +  K+ T V 
Sbjct: 544  AFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVS 603

Query: 1030 FPLENLDLSQYVI-GPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEV 1088
            FPLE LDL  ++       +  Y+L SV  H+G    GHY AYC+N     W++FDD  V
Sbjct: 604  FPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSV 663

Query: 1089 SDISVSSVKSSAAYILFY 1106
            +++S S+V+++ AY+LFY
Sbjct: 664  TEVSESTVQNAEAYVLFY 681



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 44/112 (39%), Positives = 58/112 (51%), Gaps = 7/112 (6%)

Query: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
           LTGL+N+GNTCYMN+ LQ L N P L  +F       D         K  + + +  +M 
Sbjct: 153 LTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSYLKLMT 206

Query: 836 ALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNK 886
            LW   +   + P      I  +N  F GYSQQD+QE L  LMD LHE+L +
Sbjct: 207 ELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE 258


>gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens]
          Length = 370

 Score =  133 bits (335), Expect = 8e-31
 Identities = 110/358 (30%), Positives = 162/358 (45%), Gaps = 56/358 (15%)

Query: 778  GLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK-- 835
            GL N GNTCY NS+LQ L        YF R        R  +L +K +  ++  ++    
Sbjct: 40   GLVNFGNTCYCNSVLQAL--------YFCRPF------REKVLAYKSQPRKKESLLTCLA 85

Query: 836  ------ALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLM----DGLHEDLN 885
                  A    +   I PK F   + K N+ F  Y QQD+ E L +L+    D L E+  
Sbjct: 86   DLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERK 145

Query: 886  KADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRT 945
            +     R    N D+ ++    +  W          +  +FQG   +  +CLTC   S  
Sbjct: 146  QEKQNGRLPNGNIDNENNNSTPDPTW----------VDEIFQGTLTNETRCLTCETISSK 195

Query: 946  FEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPP 1005
             E F+ LS+ +   +  T   CLR FS  E L    ++YC  CR+++++ K++++ KLP 
Sbjct: 196  DEDFLDLSVDVEQNTSIT--HCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPM 253

Query: 1006 VLLVHLKRFSYDGRWKQ--KLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYG-G 1062
            +L +HLKRF Y  +  +  KL   V FPLE L L        N  + Y+L +V  H G G
Sbjct: 254  ILALHLKRFKYMDQLHRYTKLSYRVVFPLE-LRLFNTSGDATNPDRMYDLVAVVVHCGSG 312

Query: 1063 LDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVK------------SSAAYILFYTS 1108
             + GHY A  K  +   W  FDD  V  I   +++            S + YILFY S
Sbjct: 313  PNRGHYIAIVK--SHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQS 368


>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
          Length = 1123

 Score =  131 bits (330), Expect = 3e-30
 Identities = 61/168 (36%), Positives = 96/168 (57%), Gaps = 23/168 (13%)

Query: 962  CTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWK 1021
            CTL +C + ++KEE+L  ++ + C HC+  +  + K+ +W LP +L++HLKRF   G  +
Sbjct: 540  CTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERR 599

Query: 1022 QKLQTSVDFPLENLDLSQYV----------IGPKNNLKK-------------YNLFSVSN 1058
             KL T V FPL  L+++ +V          +GP  + K+             Y+L++V N
Sbjct: 600  NKLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCN 659

Query: 1059 HYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106
            H+G L GGHYTAYC+N+   +W+ +DD  V  +    V +  AYILFY
Sbjct: 660  HHGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFY 707



 Score =  112 bits (280), Expect = 2e-24
 Identities = 65/189 (34%), Positives = 101/189 (53%), Gaps = 12/189 (6%)

Query: 770 GGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEE 829
           G   P   GL+N GNTC+MN+++QCL N   LA++     Y+    R+       EV E+
Sbjct: 94  GARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGRA-------EVTEQ 146

Query: 830 FGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADN 889
              +++ALWT +Y      +FK  + K   QF G SQ D+ E LL+L+D +HEDL   + 
Sbjct: 147 LAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDL---EG 203

Query: 890 RKRYKEENNDHLDDFKAAEHAWQKHKQ--LNESIIVALFQGQFKSTVQCLTCHKKSRTFE 947
             R         +  K +E+      Q  L +S + + FQ Q++S++ C  C K+S TF+
Sbjct: 204 SSRGPVSEKLPPEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFD 263

Query: 948 AFMYLSLPL 956
            F+ +SLP+
Sbjct: 264 PFLCVSLPI 272


>gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sapiens]
          Length = 359

 Score =  130 bits (327), Expect = 7e-30
 Identities = 109/354 (30%), Positives = 164/354 (46%), Gaps = 48/354 (13%)

Query: 778  GLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK-- 835
            GL N GNTCY NS+LQ L        YF R        R N+L +K +  ++  ++    
Sbjct: 29   GLVNFGNTCYCNSVLQAL--------YFCRPF------RENVLAYKAQQKKKENLLTCLA 74

Query: 836  ------ALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADN 889
                  A    +   I PK F   + K ND F  Y QQD+ E L +L++ + + L +   
Sbjct: 75   DLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQE--- 131

Query: 890  RKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAF 949
             ++ +E+ N  L +    E A     +L  + +  +FQG   +  +CL C   S   E F
Sbjct: 132  -EKKQEKQNGKLKNGNMNEPAENNKPEL--TWVHEIFQGTLTNETRCLNCETVSSKDEDF 188

Query: 950  MYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLV 1009
            + LS+ +   +  T   CLR FS  E L    ++YC  C +++++ K++ + KLP +L +
Sbjct: 189  LDLSVDVEQNTSIT--HCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILAL 246

Query: 1010 HLKRFSYDGRWKQ--KLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYG-GLDGG 1066
            HLKRF Y  +  +  KL   V FPLE L L        N  + Y+L +V  H G G + G
Sbjct: 247  HLKRFKYMEQLHRYTKLSYRVVFPLE-LRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRG 305

Query: 1067 HYTAYCKNAARQRWFKFDDHEVSDISVSSVK------------SSAAYILFYTS 1108
            HY    K  +   W  FDD  V  I   +++            S + YILFY S
Sbjct: 306  HYITIVK--SHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQS 357


>gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapiens]
          Length = 366

 Score =  130 bits (327), Expect = 7e-30
 Identities = 109/354 (30%), Positives = 164/354 (46%), Gaps = 48/354 (13%)

Query: 778  GLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK-- 835
            GL N GNTCY NS+LQ L        YF R        R N+L +K +  ++  ++    
Sbjct: 36   GLVNFGNTCYCNSVLQAL--------YFCRPF------RENVLAYKAQQKKKENLLTCLA 81

Query: 836  ------ALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADN 889
                  A    +   I PK F   + K ND F  Y QQD+ E L +L++ + + L +   
Sbjct: 82   DLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQE--- 138

Query: 890  RKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAF 949
             ++ +E+ N  L +    E A     +L  + +  +FQG   +  +CL C   S   E F
Sbjct: 139  -EKKQEKQNGKLKNGNMNEPAENNKPEL--TWVHEIFQGTLTNETRCLNCETVSSKDEDF 195

Query: 950  MYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLV 1009
            + LS+ +   +  T   CLR FS  E L    ++YC  C +++++ K++ + KLP +L +
Sbjct: 196  LDLSVDVEQNTSIT--HCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILAL 253

Query: 1010 HLKRFSYDGRWKQ--KLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYG-GLDGG 1066
            HLKRF Y  +  +  KL   V FPLE L L        N  + Y+L +V  H G G + G
Sbjct: 254  HLKRFKYMEQLHRYTKLSYRVVFPLE-LRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRG 312

Query: 1067 HYTAYCKNAARQRWFKFDDHEVSDISVSSVK------------SSAAYILFYTS 1108
            HY    K  +   W  FDD  V  I   +++            S + YILFY S
Sbjct: 313  HYITIVK--SHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQS 364


>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
          Length = 1352

 Score =  130 bits (327), Expect = 7e-30
 Identities = 63/169 (37%), Positives = 95/169 (56%), Gaps = 26/169 (15%)

Query: 962  CTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWK 1021
            CTL  C +L++KEE+L  ++ + C HC+  +     + +W LP VL++HLKRF  +G  +
Sbjct: 596  CTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRR 655

Query: 1022 QKLQTSVDFPLENLDLSQYVI------------------------GPKNNLKKYNLFSVS 1057
             KLQ  V FPL  LD++ +V+                         P++ +  Y+L++V 
Sbjct: 656  MKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYI--YDLYAVC 713

Query: 1058 NHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106
            NH+G + GGHYTAYCKN+    W+ FDD +V  +S   V +  AYILFY
Sbjct: 714  NHHGTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFY 762



 Score =  109 bits (273), Expect = 1e-23
 Identities = 66/192 (34%), Positives = 101/192 (52%), Gaps = 13/192 (6%)

Query: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQ-------DDINRSNLLGHKG-- 824
           P + GLRN GNTC+MN+ LQCL N    A+Y     Y+        D  +    G +G  
Sbjct: 125 PGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQG 184

Query: 825 EVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDL 884
           EV E+   +++ALWT +Y     +DFK  + K   Q+ G SQ D+QE LL+L+D +HEDL
Sbjct: 185 EVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDL 244

Query: 885 NKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSR 944
           N +  +            D      ++     +  + +  LFQ Q++S++ C  C K+S 
Sbjct: 245 NHSVKQSGQPPLKPPSETDMMPEGPSF----PVCSTFVQELFQAQYRSSLTCPHCQKQSN 300

Query: 945 TFEAFMYLSLPL 956
           TF+ F+ +SLP+
Sbjct: 301 TFDPFLCISLPI 312


>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score =  130 bits (326), Expect = 9e-30
 Identities = 74/248 (29%), Positives = 117/248 (47%), Gaps = 53/248 (21%)

Query: 912  QKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPL--------------- 956
            ++ +Q   S+I  +F G   S VQCLTC + S T E F  LSLP+               
Sbjct: 435  RRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQ 494

Query: 957  ---ASTSKC----------------------------------TLQDCLRLFSKEEKLTD 979
               A    C                                  TL+DCL  F   ++L  
Sbjct: 495  NVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKG 554

Query: 980  NNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQ 1039
            +N + C  C+  R+ +K  ++ +LP +L +HLKRF ++  +  K+ + V FPLE LDL  
Sbjct: 555  DNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRP 614

Query: 1040 YVIGP-KNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKS 1098
            ++     + +  Y+L SV  H+G    GHY AYC+N    +W++FDD  V+++  + V++
Sbjct: 615  FLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQN 674

Query: 1099 SAAYILFY 1106
            +  Y+LFY
Sbjct: 675  AEGYVLFY 682



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 42/112 (37%), Positives = 63/112 (56%), Gaps = 7/112 (6%)

Query: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
           LTG++NLGN+CYMN+ LQ L N P L  +F   C    + R++    K  + + +  ++ 
Sbjct: 144 LTGMKNLGNSCYMNAALQALSNCPPLTQFF-LEC--GGLVRTD---KKPALCKSYQKLVS 197

Query: 836 ALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNK 886
            +W   +  Y+ P      I  +N  F GY+QQD+QE L  LMD LHE+L +
Sbjct: 198 EVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKE 249


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.129    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,951,611
Number of Sequences: 37866
Number of extensions: 2386952
Number of successful extensions: 54911
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1171
Number of HSP's successfully gapped in prelim test: 1247
Number of HSP's that attempted gapping in prelim test: 14952
Number of HSP's gapped (non-prelim): 19120
length of query: 1118
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1005
effective length of database: 13,968,660
effective search space: 14038503300
effective search space used: 14038503300
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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