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Search of human proteins with 188536110
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188536110 leucine rich repeat neuronal 4 [Homo sapiens]
(740 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188536110 leucine rich repeat neuronal 4 [Homo sapiens] 1508 0.0
gi|44662821 LRRN4 C-terminal like [Homo sapiens] 111 3e-24
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 92 1e-18
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 84 5e-16
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 84 5e-16
gi|51317373 netrin-G1 ligand [Homo sapiens] 82 2e-15
gi|194440719 chondroadherin-like [Homo sapiens] 79 2e-14
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 77 4e-14
gi|61966761 leucine rich repeat containing 26 [Homo sapiens] 77 6e-14
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 77 8e-14
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 77 8e-14
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 77 8e-14
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 75 2e-13
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 74 5e-13
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 72 1e-12
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 72 2e-12
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 72 2e-12
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 72 2e-12
gi|46094076 tsukushin [Homo sapiens] 71 3e-12
gi|12007646 nyctalopin precursor [Homo sapiens] 67 5e-11
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 67 6e-11
gi|219521831 adhesion molecule with Ig-like domain 2 [Homo sapiens] 66 1e-10
gi|32469517 adhesion molecule with Ig-like domain 2 [Homo sapiens] 66 1e-10
gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens] 65 2e-10
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 65 2e-10
gi|45505137 podocan [Homo sapiens] 65 2e-10
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 65 2e-10
gi|193083139 leucine rich repeat containing 32 precursor [Homo s... 65 2e-10
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap... 65 2e-10
gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo s... 64 4e-10
>gi|188536110 leucine rich repeat neuronal 4 [Homo sapiens]
Length = 740
Score = 1508 bits (3903), Expect = 0.0
Identities = 740/740 (100%), Positives = 740/740 (100%)
Query: 1 MRQTLPLLLLTVLRPSWADPPQEKVPLFRVTQQGPWGSSGSNATDSPCEGLPAADATALT 60
MRQTLPLLLLTVLRPSWADPPQEKVPLFRVTQQGPWGSSGSNATDSPCEGLPAADATALT
Sbjct: 1 MRQTLPLLLLTVLRPSWADPPQEKVPLFRVTQQGPWGSSGSNATDSPCEGLPAADATALT 60
Query: 61 LANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGPGG 120
LANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGPGG
Sbjct: 61 LANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGPGG 120
Query: 121 PAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCT 180
PAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCT
Sbjct: 121 PAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCT 180
Query: 181 ALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPR 240
ALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPR
Sbjct: 181 ALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPR 240
Query: 241 LTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTLDS 300
LTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTLDS
Sbjct: 241 LTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTLDS 300
Query: 301 SQVLSINLFGNPLTCSCDLSWLLTDAKRTVLSRAADTMCAPAAGSSGPFSASLSLSQLPG 360
SQVLSINLFGNPLTCSCDLSWLLTDAKRTVLSRAADTMCAPAAGSSGPFSASLSLSQLPG
Sbjct: 301 SQVLSINLFGNPLTCSCDLSWLLTDAKRTVLSRAADTMCAPAAGSSGPFSASLSLSQLPG 360
Query: 361 VCQSDQSTTLGASHPPCFNRSTYAQGTTVAPSAAPATRPAGDQQSVSKAPNVGSRTIAAW 420
VCQSDQSTTLGASHPPCFNRSTYAQGTTVAPSAAPATRPAGDQQSVSKAPNVGSRTIAAW
Sbjct: 361 VCQSDQSTTLGASHPPCFNRSTYAQGTTVAPSAAPATRPAGDQQSVSKAPNVGSRTIAAW 420
Query: 421 PHSDAREGTAPSTTNSVAGHSNSSVFPRAASTTRTQHRGEHAPELVLEPDISAASTPLAS 480
PHSDAREGTAPSTTNSVAGHSNSSVFPRAASTTRTQHRGEHAPELVLEPDISAASTPLAS
Sbjct: 421 PHSDAREGTAPSTTNSVAGHSNSSVFPRAASTTRTQHRGEHAPELVLEPDISAASTPLAS 480
Query: 481 KLLGPFPTSWDRSISSPQPGQRTHATPQAPNPSLSEGEIPVLLLDDYSEEEEGRKEEVGT 540
KLLGPFPTSWDRSISSPQPGQRTHATPQAPNPSLSEGEIPVLLLDDYSEEEEGRKEEVGT
Sbjct: 481 KLLGPFPTSWDRSISSPQPGQRTHATPQAPNPSLSEGEIPVLLLDDYSEEEEGRKEEVGT 540
Query: 541 PHQDVPCDYHPCKHLQTPCAELQRRWRCRCPGLSGEDTIPDPPRLQGVTETTDTSALVHW 600
PHQDVPCDYHPCKHLQTPCAELQRRWRCRCPGLSGEDTIPDPPRLQGVTETTDTSALVHW
Sbjct: 541 PHQDVPCDYHPCKHLQTPCAELQRRWRCRCPGLSGEDTIPDPPRLQGVTETTDTSALVHW 600
Query: 601 CAPNSVVHGYQIRYSAEGWAGNQSVVGVIYATARQHPLYGLSPGTTYRVCVLAANRAGLS 660
CAPNSVVHGYQIRYSAEGWAGNQSVVGVIYATARQHPLYGLSPGTTYRVCVLAANRAGLS
Sbjct: 601 CAPNSVVHGYQIRYSAEGWAGNQSVVGVIYATARQHPLYGLSPGTTYRVCVLAANRAGLS 660
Query: 661 QPRSSGWRSPCAAFTTKPSFALLLSGLCAASGLLLASTVVLSACLCRRGQTLGLQRCDTH 720
QPRSSGWRSPCAAFTTKPSFALLLSGLCAASGLLLASTVVLSACLCRRGQTLGLQRCDTH
Sbjct: 661 QPRSSGWRSPCAAFTTKPSFALLLSGLCAASGLLLASTVVLSACLCRRGQTLGLQRCDTH 720
Query: 721 LVAYKNPAFDDYPLGLQTVS 740
LVAYKNPAFDDYPLGLQTVS
Sbjct: 721 LVAYKNPAFDDYPLGLQTVS 740
>gi|44662821 LRRN4 C-terminal like [Homo sapiens]
Length = 238
Score = 111 bits (277), Expect = 3e-24
Identities = 75/198 (37%), Positives = 95/198 (47%), Gaps = 22/198 (11%)
Query: 526 DYSEEEEGRKEEVGTPHQDVPCDYHPCKHLQTPCAELQR--RWRCRCPGLSGEDTIPDPP 583
D+ EEE E P VPCDY C+HLQ PC ELQR C CPGLS PDPP
Sbjct: 27 DFEEEEADETETAWPPLPAVPCDYDHCRHLQVPCKELQRVGPAACLCPGLSSPAQPPDPP 86
Query: 584 RLQGVTETTDTS-ALVHWCAPNSVVHGYQIRYSAEGWAGNQSVV--GVIYATARQHPLYG 640
R+ V + A+VHWCAP S V Y + W G+++ + AT R+ L G
Sbjct: 87 RMGEVRIAAEEGRAVVHWCAPFSPVLHYWLLL----WDGSEAAQKGPPLNATVRRAELKG 142
Query: 641 LSPGTTYRVCVLAANRAGLSQPRSSGWR----------SPCAAFTTKPSFALLLS---GL 687
L PG Y VCV+AAN AG S+ +G PC+ P+ L+ G+
Sbjct: 143 LKPGGIYVVCVVAANEAGASRVPQAGGEGLEGADIPAFGPCSRLAVPPNPRTLVHAAVGV 202
Query: 688 CAASGLLLASTVVLSACL 705
A LL + +V CL
Sbjct: 203 GTALALLSCAALVWHFCL 220
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 92.4 bits (228), Expect = 1e-18
Identities = 95/328 (28%), Positives = 143/328 (43%), Gaps = 26/328 (7%)
Query: 37 GSSGSNATDSPCEGLPAADATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELG 96
G AT P + A+ + R+L +P +P R L+ N ++ + T
Sbjct: 48 GGGSPPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFK 107
Query: 97 HLEQLQVLTLRHNRIAALRWGP-GGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAG 155
HL L++L L N + + G G L+TL+L N+L +P LS LR L L
Sbjct: 108 HLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRN 167
Query: 156 NPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTF 215
NP+ ++ AF P+L+ L+L L R I+EAAF G LV L L+L
Sbjct: 168 NPIESIPSYAFNRVPSLRRLDLG--ELKRLEY--ISEAAFEG-----LVNLRYLNLGMCN 218
Query: 216 LERVESGWIRDLPKLTSLY-LRKMP----RLTTLEGDIFKMTPNLQQLDCQDSPALASVA 270
L +D+P LT+L L ++ RL + F+ +L++L + +A++
Sbjct: 219 L--------KDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHA-QVATIE 269
Query: 271 THIFQDTPHLQVLLFQNCNLSSFPPWTLDSSQVLS-INLFGNPLTCSCDLSWLLTDAKRT 329
+ F D L+ L + NL S P L ++L NP C+CD+ WL K T
Sbjct: 270 RNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKET 329
Query: 330 VLSR-AADTMCAPAAGSSGPFSASLSLS 356
V S C AG G + L S
Sbjct: 330 VPSNTTCCARCHAPAGLKGRYIGELDQS 357
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 84.0 bits (206), Expect = 5e-16
Identities = 82/309 (26%), Positives = 128/309 (41%), Gaps = 19/309 (6%)
Query: 38 SSGSNATDSPCEGLPAADATALTLANRNLERLPGCLPRTLRSLDA---SHNLLRALSTSE 94
+S S+A D LP +L L L RL L SL +HN L ++
Sbjct: 103 NSFSDARDCDFHALP--QLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRA 160
Query: 95 LGHLEQLQVLTLRHNRIAAL--RWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALA 152
L L L L N + A+ RW P L L + N++ A+ L++LR+L
Sbjct: 161 FSGLSNLLRLHLNSNLLRAIDSRWFEMLP-NLEILMIGGNKVDAILDMNFRPLANLRSLV 219
Query: 153 LAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLS 212
LAG LR + A +L+ L+ L R + + + L+ LDL+
Sbjct: 220 LAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVP----------GLKFLDLN 269
Query: 213 GTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATH 272
L+RV G ++ L L L M L +++ P L +LD ++P L+ +
Sbjct: 270 KNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPR 329
Query: 273 IFQDTPHLQVLLFQNCNLSSFPPWTLDS-SQVLSINLFGNPLTCSCDLSWLLTDAKRTVL 331
F P ++ L+ N LS+ T++S + + L GNP+ C C + W R
Sbjct: 330 AFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRF 389
Query: 332 SRAADTMCA 340
T+CA
Sbjct: 390 IEPQSTLCA 398
Score = 53.5 bits (127), Expect = 7e-07
Identities = 70/262 (26%), Positives = 105/262 (40%), Gaps = 40/262 (15%)
Query: 55 DATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAAL 114
+AT + + L +P LP ++L N + + SELG+L
Sbjct: 49 EATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYL---------------- 92
Query: 115 RWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQL 174
A L LDLS N + C AL L +L L N L L+ +FA +LQ
Sbjct: 93 -------ANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQE 145
Query: 175 LNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLY 234
L L+ L R IA AF+G L L L L+ L ++S W LP L L
Sbjct: 146 LYLNHNQLYR-----IAPRAFSG-----LSNLLRLHLNSNLLRAIDSRWFEMLPNLEILM 195
Query: 235 L--RKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSS 292
+ K+ + + F+ NL+ L L ++ + + L+ L F + L+
Sbjct: 196 IGGNKVDAILDMN---FRPLANLRSL-VLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
Query: 293 FPPWTLDSSQVLS-INLFGNPL 313
P L+ L ++L NPL
Sbjct: 252 VPRRALEQVPGLKFLDLNKNPL 273
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 84.0 bits (206), Expect = 5e-16
Identities = 82/309 (26%), Positives = 128/309 (41%), Gaps = 19/309 (6%)
Query: 38 SSGSNATDSPCEGLPAADATALTLANRNLERLPGCLPRTLRSLDA---SHNLLRALSTSE 94
+S S+A D LP +L L L RL L SL +HN L ++
Sbjct: 103 NSFSDARDCDFHALP--QLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRA 160
Query: 95 LGHLEQLQVLTLRHNRIAAL--RWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALA 152
L L L L N + A+ RW P L L + N++ A+ L++LR+L
Sbjct: 161 FSGLSNLLRLHLNSNLLRAIDSRWFEMLP-NLEILMIGGNKVDAILDMNFRPLANLRSLV 219
Query: 153 LAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLS 212
LAG LR + A +L+ L+ L R + + + L+ LDL+
Sbjct: 220 LAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVP----------GLKFLDLN 269
Query: 213 GTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATH 272
L+RV G ++ L L L M L +++ P L +LD ++P L+ +
Sbjct: 270 KNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPR 329
Query: 273 IFQDTPHLQVLLFQNCNLSSFPPWTLDS-SQVLSINLFGNPLTCSCDLSWLLTDAKRTVL 331
F P ++ L+ N LS+ T++S + + L GNP+ C C + W R
Sbjct: 330 AFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRF 389
Query: 332 SRAADTMCA 340
T+CA
Sbjct: 390 IEPQSTLCA 398
Score = 53.5 bits (127), Expect = 7e-07
Identities = 70/262 (26%), Positives = 105/262 (40%), Gaps = 40/262 (15%)
Query: 55 DATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAAL 114
+AT + + L +P LP ++L N + + SELG+L
Sbjct: 49 EATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYL---------------- 92
Query: 115 RWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQL 174
A L LDLS N + C AL L +L L N L L+ +FA +LQ
Sbjct: 93 -------ANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQE 145
Query: 175 LNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLY 234
L L+ L R IA AF+G L L L L+ L ++S W LP L L
Sbjct: 146 LYLNHNQLYR-----IAPRAFSG-----LSNLLRLHLNSNLLRAIDSRWFEMLPNLEILM 195
Query: 235 L--RKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSS 292
+ K+ + + F+ NL+ L L ++ + + L+ L F + L+
Sbjct: 196 IGGNKVDAILDMN---FRPLANLRSL-VLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
Query: 293 FPPWTLDSSQVLS-INLFGNPL 313
P L+ L ++L NPL
Sbjct: 252 VPRRALEQVPGLKFLDLNKNPL 273
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 81.6 bits (200), Expect = 2e-15
Identities = 68/273 (24%), Positives = 118/273 (43%), Gaps = 39/273 (14%)
Query: 64 RNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGP-GGPA 122
+NL +P + R L+ N ++ + + HL L++L L N I + G G A
Sbjct: 65 KNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLA 124
Query: 123 GLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLS---- 178
L+TL+L N+L +P LS L+ L L NP+ ++ AF P+L+ L+L
Sbjct: 125 NLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKR 184
Query: 179 CTALGRGAQGGIAEAAFAG---------EDGAPLVTLEVLDLSGTFLERVESGWIRDLPK 229
+ + GA G++ + + PL+ L+ LDLSG L + G + L
Sbjct: 185 LSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMH 244
Query: 230 LTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCN 289
L L++ + ++ +E + F +L +++ + L + +F HL+
Sbjct: 245 LQKLWMIQ-SQIQVIERNAFDNLQSLVEINLAHN-NLTLLPHDLFTPLHHLE-------- 294
Query: 290 LSSFPPWTLDSSQVLSINLFGNPLTCSCDLSWL 322
I+L NP C+CD+ WL
Sbjct: 295 ---------------RIHLHHNPWNCNCDILWL 312
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 79.0 bits (193), Expect = 2e-14
Identities = 83/278 (29%), Positives = 111/278 (39%), Gaps = 22/278 (7%)
Query: 64 RNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGP-GGPA 122
+NL +P +P + LD NLL+ + + + L L LRH + + G G
Sbjct: 51 QNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLG 110
Query: 123 GLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCTAL 182
L L+L+ N L LP L SLR L L GN L L+P F AL LNL+ AL
Sbjct: 111 RLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNAL 170
Query: 183 ----GRGAQGGI----------AEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLP 228
QG + A + A E A L L L L L+ + +
Sbjct: 171 VYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQAR 230
Query: 229 KLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNC 288
L L L P E D + P L++L D AL ++ F P L L +
Sbjct: 231 GLARLELGHNPLTYAGEEDGLAL-PGLREL-LLDGGALQALGPRAFAHCPRLHTLDLRGN 288
Query: 289 NLSSFPPWTLDSSQVLSINLFGNPLTCSCD----LSWL 322
L + PP Q+ + L GNPL C C L WL
Sbjct: 289 QLDTLPPLQ-GPGQLRRLRLQGNPLWCGCQARPLLEWL 325
Score = 57.4 bits (137), Expect = 5e-08
Identities = 84/309 (27%), Positives = 112/309 (36%), Gaps = 20/309 (6%)
Query: 29 RVTQQGPWGSSGSNATDSPCEG--LPAADATALTLANRNLERLPGCLPRTLRSLDASHNL 86
R +GP G +PC + ++ + L+ +P P + LD N
Sbjct: 377 RAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNH 436
Query: 87 LRALSTSELGHLEQLQVLTLRHNRIAALRWGP-GGPAGLHTLDLSYNQLAALPPCTGPAL 145
++ + L L L L+H IA L G G L L LS NQLA L
Sbjct: 437 FPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGA 496
Query: 146 SSLRALALAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAA------FAGED 199
L L L N + A P+L L+L A+ R A G + +G
Sbjct: 497 PRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNR 556
Query: 200 ------GA--PLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKM 251
GA P LE L L L V +G + LP L L L P +G +
Sbjct: 557 ITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPV 616
Query: 252 TPNLQQLDCQDSPALASVATHIFQDT-PHLQVLLFQNCNLSSFPPWTLDSSQVLSINLFG 310
+LQ L S L + F P LQ L Q L + P SQ+ I+L
Sbjct: 617 GRSLQHLFLNSS-GLEQICPGAFSGLGPGLQSLHLQKNQLRALPALP-SLSQLELIDLSS 674
Query: 311 NPLTCSCDL 319
NP C C L
Sbjct: 675 NPFHCDCQL 683
Score = 56.6 bits (135), Expect = 8e-08
Identities = 71/240 (29%), Positives = 100/240 (41%), Gaps = 54/240 (22%)
Query: 44 TDSPCEGLPAADATA------LTLANRNLERLPGCLPRTLRSLDASH---NLLRALSTSE 94
+D+ GL AA L L ++PG R L SL + H N + L+ +
Sbjct: 481 SDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGD 540
Query: 95 LGHLEQLQVLTLRHNRIAALRWGPGGPAG-LHTLDLSYNQLAALPPCTGPALSSLRALAL 153
LG L+ + L NRI + G GPA L L L NQL +P L +L L L
Sbjct: 541 LGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQL 600
Query: 154 AGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSG 213
+GNPLRAL+ AF +GR +L+ L L+
Sbjct: 601 SGNPLRALRDGAF-------------QPVGR--------------------SLQHLFLNS 627
Query: 214 TFLERVESGWIRDL-PKLTSLYLRK--------MPRLTTLEGDIFKMTPNLQQLDCQDSP 264
+ LE++ G L P L SL+L+K +P L+ LE + ++ N DCQ P
Sbjct: 628 SGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLE--LIDLSSNPFHCDCQLLP 685
Score = 37.0 bits (84), Expect = 0.066
Identities = 63/243 (25%), Positives = 92/243 (37%), Gaps = 16/243 (6%)
Query: 119 GGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLS 178
G P+ LDL N ++P P L L +L L + L+ A A L L LS
Sbjct: 422 GFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLS 481
Query: 179 CTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKM 238
L G++ AA +GAP L L L +V +R LP L SL+L+
Sbjct: 482 DNQL-----AGLSAAAL---EGAP--RLGYLYLERNRFLQVPGAALRALPSLFSLHLQDN 531
Query: 239 PRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTL 298
GD+ + T L+ + + + V+ L+ L L P L
Sbjct: 532 AVDRLAPGDLGR-TRALRWVYLSGN-RITEVSLGALGPARELEKLHLDRNQLREVPTGAL 589
Query: 299 DS-SQVLSINLFGNPLTCSCDLSWLLTDAKRTVL---SRAADTMCAPAAGSSGPFSASLS 354
+ +L + L GNPL D ++ L S + +C A GP SL
Sbjct: 590 EGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLH 649
Query: 355 LSQ 357
L +
Sbjct: 650 LQK 652
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 77.4 bits (189), Expect = 4e-14
Identities = 72/274 (26%), Positives = 110/274 (40%), Gaps = 41/274 (14%)
Query: 64 RNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGP-GGPA 122
R L +P +P R L+ N ++ + HL L+VL L N I + G G A
Sbjct: 64 RGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLA 123
Query: 123 GLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNL----S 178
L+TL+L N L +P LS LR L L NP+ ++ AF P+L L+L
Sbjct: 124 SLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKK 183
Query: 179 CTALGRGAQGGIAEAAFAG---------EDGAPLVTLEVLDLSGTFLERVESGWIRDLPK 229
+ GA G+ + + PLV LE L++SG + G L
Sbjct: 184 LEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSS 243
Query: 230 LTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCN 289
L L++ +++ +E + F +L +L+ + N
Sbjct: 244 LKKLWVMN-SQVSLIERNAFDGLASLVELNLAHN-------------------------N 277
Query: 290 LSSFPPWTLDSSQVL-SINLFGNPLTCSCDLSWL 322
LSS P + L ++L NP C CD+ WL
Sbjct: 278 LSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWL 311
>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
Length = 334
Score = 77.0 bits (188), Expect = 6e-14
Identities = 68/187 (36%), Positives = 85/187 (45%), Gaps = 16/187 (8%)
Query: 6 PLLLLTVLRPSWADPPQEKVPLFRVTQQGPWGSSGSNATDSPCEGLPAADATALTLANRN 65
PLLLL +L W P +V P GS G+ C +P A+ L+
Sbjct: 11 PLLLLLLLLSPW--PVWAQVS----ATASPSGSLGAPDCPEVCTCVPGGLASCSALS--- 61
Query: 66 LERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALR----WGPGGP 121
L +P L LR+L HN +RAL LQ L LR N + ++ WG G
Sbjct: 62 LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGA- 120
Query: 122 AGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCTA 181
L LDLS NQL AL P T L +LR L+LAGN L L+P A P L+ L+L
Sbjct: 121 --LQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNE 178
Query: 182 LGRGAQG 188
L A G
Sbjct: 179 LAALAPG 185
Score = 55.5 bits (132), Expect = 2e-07
Identities = 50/147 (34%), Positives = 65/147 (44%), Gaps = 11/147 (7%)
Query: 118 PGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNL 177
PG L L L +N++ ALPP +L+ L L N L ++ RAF ALQLL+L
Sbjct: 67 PGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDL 126
Query: 178 SCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRK 237
S L A G APL L L L+G L R+E + LP L SL L+
Sbjct: 127 SANQLEALAPGTF----------APLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQD 176
Query: 238 MPRLTTLEGDIFKMTPNLQQLDCQDSP 264
L L + P L L + +P
Sbjct: 177 -NELAALAPGLLGRLPALDALHLRGNP 202
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 76.6 bits (187), Expect = 8e-14
Identities = 72/305 (23%), Positives = 130/305 (42%), Gaps = 37/305 (12%)
Query: 43 ATDSPCE--GLPAADATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQ 100
+TD P GL + ++ N N++++P L S+ N L L L L
Sbjct: 87 STDFPVNLTGLDLSQNNLSSVTNINVKKMPQLL-----SVYLEENKLTELPEKCLSELSN 141
Query: 101 LQVLTLRHNRIAALRWGPGGPAGLHTL---DLSYNQLAALPPCTGPALSSLRALALAGNP 157
LQ L + HN ++ + PG GLH L L+ N+L + AL +L L + NP
Sbjct: 142 LQELYINHNLLSTI--SPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENP 199
Query: 158 LRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAP--------------- 202
+ ++ F L+NL + I + A G +
Sbjct: 200 IIRIKDMNFK-----PLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHV 254
Query: 203 ----LVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQL 258
+V L+ LDL+ + R+ G ++ L L + MP L +++ P+L+++
Sbjct: 255 ALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKI 314
Query: 259 DCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTLDS-SQVLSINLFGNPLTCSC 317
+ ++P L+ + + F P L+ L+ + LS+ T++S + I++ NP+ C C
Sbjct: 315 EATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDC 374
Query: 318 DLSWL 322
+ W+
Sbjct: 375 VIRWM 379
Score = 45.8 bits (107), Expect = 1e-04
Identities = 43/157 (27%), Positives = 67/157 (42%), Gaps = 11/157 (7%)
Query: 102 QVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRAL 161
Q+L L+ N IA + + P L LDLS N L+++ + L ++ L N L L
Sbjct: 72 QILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTEL 131
Query: 162 QPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVES 221
+ + +L NL + I+ AF G L L L L+ L+ + S
Sbjct: 132 PEKCLS-----ELSNLQELYINHNLLSTISPGAFIG-----LHNLLRLHLNSNRLQMINS 181
Query: 222 GWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQL 258
W LP L L + + P + ++ FK NL+ L
Sbjct: 182 KWFDALPNLEILMIGENP-IIRIKDMNFKPLINLRSL 217
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 76.6 bits (187), Expect = 8e-14
Identities = 72/305 (23%), Positives = 130/305 (42%), Gaps = 37/305 (12%)
Query: 43 ATDSPCE--GLPAADATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQ 100
+TD P GL + ++ N N++++P L S+ N L L L L
Sbjct: 87 STDFPVNLTGLDLSQNNLSSVTNINVKKMPQLL-----SVYLEENKLTELPEKCLSELSN 141
Query: 101 LQVLTLRHNRIAALRWGPGGPAGLHTL---DLSYNQLAALPPCTGPALSSLRALALAGNP 157
LQ L + HN ++ + PG GLH L L+ N+L + AL +L L + NP
Sbjct: 142 LQELYINHNLLSTI--SPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENP 199
Query: 158 LRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAP--------------- 202
+ ++ F L+NL + I + A G +
Sbjct: 200 IIRIKDMNFK-----PLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHV 254
Query: 203 ----LVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQL 258
+V L+ LDL+ + R+ G ++ L L + MP L +++ P+L+++
Sbjct: 255 ALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKI 314
Query: 259 DCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTLDS-SQVLSINLFGNPLTCSC 317
+ ++P L+ + + F P L+ L+ + LS+ T++S + I++ NP+ C C
Sbjct: 315 EATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDC 374
Query: 318 DLSWL 322
+ W+
Sbjct: 375 VIRWM 379
Score = 45.8 bits (107), Expect = 1e-04
Identities = 43/157 (27%), Positives = 67/157 (42%), Gaps = 11/157 (7%)
Query: 102 QVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRAL 161
Q+L L+ N IA + + P L LDLS N L+++ + L ++ L N L L
Sbjct: 72 QILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTEL 131
Query: 162 QPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVES 221
+ + +L NL + I+ AF G L L L L+ L+ + S
Sbjct: 132 PEKCLS-----ELSNLQELYINHNLLSTISPGAFIG-----LHNLLRLHLNSNRLQMINS 181
Query: 222 GWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQL 258
W LP L L + + P + ++ FK NL+ L
Sbjct: 182 KWFDALPNLEILMIGENP-IIRIKDMNFKPLINLRSL 217
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 76.6 bits (187), Expect = 8e-14
Identities = 72/305 (23%), Positives = 130/305 (42%), Gaps = 37/305 (12%)
Query: 43 ATDSPCE--GLPAADATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQ 100
+TD P GL + ++ N N++++P L S+ N L L L L
Sbjct: 87 STDFPVNLTGLDLSQNNLSSVTNINVKKMPQLL-----SVYLEENKLTELPEKCLSELSN 141
Query: 101 LQVLTLRHNRIAALRWGPGGPAGLHTL---DLSYNQLAALPPCTGPALSSLRALALAGNP 157
LQ L + HN ++ + PG GLH L L+ N+L + AL +L L + NP
Sbjct: 142 LQELYINHNLLSTI--SPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENP 199
Query: 158 LRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAP--------------- 202
+ ++ F L+NL + I + A G +
Sbjct: 200 IIRIKDMNFK-----PLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHV 254
Query: 203 ----LVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQL 258
+V L+ LDL+ + R+ G ++ L L + MP L +++ P+L+++
Sbjct: 255 ALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKI 314
Query: 259 DCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTLDS-SQVLSINLFGNPLTCSC 317
+ ++P L+ + + F P L+ L+ + LS+ T++S + I++ NP+ C C
Sbjct: 315 EATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDC 374
Query: 318 DLSWL 322
+ W+
Sbjct: 375 VIRWM 379
Score = 45.8 bits (107), Expect = 1e-04
Identities = 43/157 (27%), Positives = 67/157 (42%), Gaps = 11/157 (7%)
Query: 102 QVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRAL 161
Q+L L+ N IA + + P L LDLS N L+++ + L ++ L N L L
Sbjct: 72 QILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTEL 131
Query: 162 QPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVES 221
+ + +L NL + I+ AF G L L L L+ L+ + S
Sbjct: 132 PEKCLS-----ELSNLQELYINHNLLSTISPGAFIG-----LHNLLRLHLNSNRLQMINS 181
Query: 222 GWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQL 258
W LP L L + + P + ++ FK NL+ L
Sbjct: 182 KWFDALPNLEILMIGENP-IIRIKDMNFKPLINLRSL 217
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 75.1 bits (183), Expect = 2e-13
Identities = 90/304 (29%), Positives = 132/304 (43%), Gaps = 37/304 (12%)
Query: 40 GSNATDSPCEGLPAA--DATALTLANRNLERLPGC---LPRTLRSLDASHNLLRALSTSE 94
G+N + EGL +A L L RLP L L LD SHN L AL
Sbjct: 71 GNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEV 130
Query: 95 LGHLEQLQVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALA 154
+ L +L+ L L HN++ AL G A L LD+S+N+LA LP LS LR L +
Sbjct: 131 VSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLS-CLSRLRTLDVD 189
Query: 155 GNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGT 214
N L A PR AL+ L++S L RG ED + L L++L LSG
Sbjct: 190 HNQLTAF-PRQLLQLVALEELDVSSNRL-RGLP----------EDISALRALKILWLSGA 237
Query: 215 FLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIF 274
L + +G+ +L L SL L+ + + P Q C + ++++++F
Sbjct: 238 ELGTLPAGFC-ELASLESL---------MLDNNGLQALP--AQFSCLQRLKMLNLSSNLF 285
Query: 275 QDTP-------HLQVLLFQNCNLSSFPPWTLDSSQVLSINLFGNPLTCSCDLSWLLTDAK 327
++ P L+ L L+S P ++L++ L N + D LT +
Sbjct: 286 EEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLE 345
Query: 328 RTVL 331
VL
Sbjct: 346 ELVL 349
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 73.9 bits (180), Expect = 5e-13
Identities = 88/304 (28%), Positives = 115/304 (37%), Gaps = 62/304 (20%)
Query: 35 PWGSSGSNATDSPCEGLPAADATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSE 94
P GS GS C P A + +R LE +PG LP LD S N L L
Sbjct: 24 PGGSGGSCPAVCDCTSQPQA----VLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGM 79
Query: 95 LGHLEQLQVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALA 154
L L LQ LDLSYNQL+ L P L SL L L
Sbjct: 80 LSRLSLLQ-----------------------ELDLSYNQLSTLEPGAFHGLQSLLTLRLQ 116
Query: 155 GNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGT 214
GN LR + P F+ AL LL+L + G E L +L+ L++
Sbjct: 117 GNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGE----------LGSLQKLEVGDN 166
Query: 215 FLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTP-----NLQQLDCQDSPA---- 265
L V G L KL++L L + L+T+ G P L++LD PA
Sbjct: 167 HLVFVAPGAFAGLAKLSTLTLERC-NLSTVPGLALARLPALVALRLRELDIGRLPAGALR 225
Query: 266 ----LASVATHIFQDTP----------HLQVLLFQNCNLSSFPPWTLDSSQVLSI-NLFG 310
L + H++ +L L CNLSS P L L + +L
Sbjct: 226 GLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQ 285
Query: 311 NPLT 314
NP++
Sbjct: 286 NPIS 289
Score = 35.8 bits (81), Expect = 0.15
Identities = 48/175 (27%), Positives = 69/175 (39%), Gaps = 39/175 (22%)
Query: 60 TLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGPG 119
T+ L RLP + LR LD L A + LG L++L++ H + PG
Sbjct: 194 TVPGLALARLPALVALRLRELDIGR--LPAGALRGLGQLKELEI----HLWPSLEALDPG 247
Query: 120 GPAGLH--------------------------TLDLSYNQLAALPPCTGPALSSLRALAL 153
GL+ LDLS N ++A+P L L+ L L
Sbjct: 248 SLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRL 307
Query: 154 AGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEV 208
+G L ++ AF A LL+++ AL + E AF D LVTL +
Sbjct: 308 SGACLTSIAAHAFHGLTAFHLLDVADNALQT-----LEETAFPSPD--KLVTLRL 355
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 72.4 bits (176), Expect = 1e-12
Identities = 130/503 (25%), Positives = 183/503 (36%), Gaps = 85/503 (16%)
Query: 77 LRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGP-GGPAGLHTLDLSYNQLA 135
L L +NLL+AL+ L L +L++L N I+ L G G L L L N L
Sbjct: 109 LEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALG 168
Query: 136 ALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAF 195
ALP L +L L L N +R L AFA L+ LNLS L Q + AA
Sbjct: 169 ALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANEL----QPSLRHAA- 223
Query: 196 AGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNL 255
APL +L L LS L+ + + LP+L L LR +LT L + F L
Sbjct: 224 ---TFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRG-NQLTHLAPEAFWGLEAL 279
Query: 256 QQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTLD---------------- 299
++L + + L+ + T + + L+ L LS+ P T
Sbjct: 280 RELRLEGN-RLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALS 338
Query: 300 ---------SSQVLSINLFGNPLTCSCDLSWL---LTDAKRTVLSRAADTMCAPAAGSSG 347
S + ++L GN TC C L L + D C G
Sbjct: 339 ALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRG 398
Query: 348 PFSASLSLSQLPGVCQSDQSTTLGASHPPCFNRSTYAQGTTVAPSAAPATRPAGDQQSVS 407
+ L QL +D S + + A G + P PAG + +
Sbjct: 399 KYLDYLDDQQLQNGSCADPSPSASLTADRRRQPLPTAAGEEMTP-------PAGLAEELP 451
Query: 408 KAPNV--GSRTIA--AWPHSDAREGTAPSTTNSVAGHSNSSVFPRAASTTRTQHRGEHAP 463
P + R +A AW G + V R+A + G P
Sbjct: 452 PQPQLQQQGRFLAGVAWD-----------------GAARELVGNRSALRLSRRGPGLQQP 494
Query: 464 ELVLEPDISAASTPLASKLLGPFPTSWDRSISSPQPGQRTHATP--QAPNPSLSEGEIPV 521
P ++AA+ GP P S D PQ G+ T A P P P+ S G P
Sbjct: 495 ----SPSVAAAA--------GPAPQSLDLH-KKPQRGRPTRADPALAEPTPTASPGSAPS 541
Query: 522 LLLDDYSEEEEGRKEEVGTPHQD 544
D + + K +GT HQ+
Sbjct: 542 PAGDPW---QRATKHRLGTEHQE 561
Score = 57.0 bits (136), Expect = 6e-08
Identities = 118/426 (27%), Positives = 148/426 (34%), Gaps = 97/426 (22%)
Query: 75 RTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALR----WGPGGPAGLHTLDLS 130
R+L SL S N L+ L HL +L +L+LR N++ L WG L L L
Sbjct: 229 RSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGL---EALRELRLE 285
Query: 131 YNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGI 190
N+L+ LP L SL AL L+GN L AL P F L+ L+L AL
Sbjct: 286 GNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNAL-------- 337
Query: 191 AEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFK 250
+A +G+ A L LDL G +GW D ++ L GD
Sbjct: 338 --SALSGDIFAASPALYRLDLDG-------NGWTCDC---------RLRGLKRWMGDWHS 379
Query: 251 MTPNLQQ-LDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTLDSSQVLSINLF 309
L + C+ PAL D Q L +C D S S
Sbjct: 380 QGRLLTVFVQCRHPPALRGKYLDYLDD----QQLQNGSC---------ADPSPSAS---- 422
Query: 310 GNPLTCSCDLSWLLTDAKRTVLSRAADTMCAPAAGSSGPFSASLSLSQ----LPGVCQSD 365
L D +R L AA P AG + L Q L GV
Sbjct: 423 ------------LTADRRRQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRFLAGVAWD- 469
Query: 366 QSTTLGASHPPCFNRSTYAQG------TTVAPSAAPATRPAGDQQSVSKAPNVGSRTIA- 418
GA+ NRS +PS A A PA + K P G T A
Sbjct: 470 -----GAARELVGNRSALRLSRRGPGLQQPSPSVAAAAGPAPQSLDLHKKPQRGRPTRAD 524
Query: 419 ---AWPHSDAREGTAPSTTNSVAGHSNSSVFPRAASTTRTQHR-GEHAPELVLEPDISAA 474
A P A G+APS + RA T+HR G E + D A
Sbjct: 525 PALAEPTPTASPGSAPSPA--------GDPWQRA-----TKHRLGTEHQERAAQSDGGAG 571
Query: 475 STPLAS 480
PL S
Sbjct: 572 LPPLVS 577
Score = 55.1 bits (131), Expect = 2e-07
Identities = 50/131 (38%), Positives = 63/131 (48%), Gaps = 6/131 (4%)
Query: 52 PAADATALTLANRNLE----RLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLR 107
P ++L L+ NL+ R+ LPR L L N L L+ LE L+ L L
Sbjct: 227 PLRSLSSLILSANNLQHLGPRIFQHLPR-LGLLSLRGNQLTHLAPEAFWGLEALRELRLE 285
Query: 108 HNRIAALRWGPGGPA-GLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAF 166
NR++ L P L LDLS N+L+AL P T L LR L+L N L AL F
Sbjct: 286 GNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIF 345
Query: 167 ACFPALQLLNL 177
A PAL L+L
Sbjct: 346 AASPALYRLDL 356
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 72.0 bits (175), Expect = 2e-12
Identities = 103/408 (25%), Positives = 156/408 (38%), Gaps = 57/408 (13%)
Query: 59 LTLANRNLERLP-GCLPRT--LRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALR 115
L L +LE +P G L L+ N L +S HL LQVL L NR+ +
Sbjct: 160 LQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIP 219
Query: 116 WG----------------------PG---GPAGLHTLDLSYNQLAALPPCTGPALSSLRA 150
G PG L L LS N ++ LPP L L
Sbjct: 220 MGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNR 279
Query: 151 LALAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLD 210
L L GN L+ L F P L+ L L + + + F+ L L+VL
Sbjct: 280 LTLFGNSLKELSLGIFGPMPNLRELWLYDNHI-----SSLPDNVFSN-----LRQLQVLI 329
Query: 211 LSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVA 270
LS + + G L +L L L L L+G++F+M NLQ + Q++ L +
Sbjct: 330 LSRNQISFISPGAFNGLTELRELSLH-TNALQDLDGNVFRMLANLQNISLQNN-RLRQLP 387
Query: 271 THIFQDTPHLQVLLFQNCNLSSFPPWTLDS-SQVLSINLFGNPLTCSCDL----SWLLTD 325
+IF + L + QN L + P D ++ + L+ NP C D+ +WLL +
Sbjct: 388 GNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLN 447
Query: 326 AKRTVLSRAADTMCAPAAGSSGPFSASLSLS-QLPGVCQSDQSTTLGASHP--PCFNRST 382
R L +C A G ++++ +P V + S+P P + +
Sbjct: 448 QPR--LGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEV-----PSYPETPWYPDTP 500
Query: 383 YAQGTTVAPSAAPATRPAGDQQSVSKAPNVGSRTIAAWPHSDAREGTA 430
TT S T P D ++ R++ W + A+ G A
Sbjct: 501 SYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSV--WGMTQAQSGLA 546
Score = 48.5 bits (114), Expect = 2e-05
Identities = 60/216 (27%), Positives = 87/216 (40%), Gaps = 35/216 (16%)
Query: 122 AGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCTA 181
+ L L + N+L+ + P L SLR L+LA N L+ L F +L+ L LS
Sbjct: 83 SALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQ 142
Query: 182 LGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMP-- 239
L + I A F + L+ L L G LE + G L LT L L K
Sbjct: 143 LLQ-----IQPAHF-----SQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLT 192
Query: 240 ---------------------RLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTP 278
RLT + F NLQ+L Q + + ++ +F +
Sbjct: 193 HISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQN-QIGLLSPGLFHNNH 251
Query: 279 HLQVLLFQNCNLSSFPPWT-LDSSQVLSINLFGNPL 313
+LQ L N ++S PP + Q+ + LFGN L
Sbjct: 252 NLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSL 287
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 72.0 bits (175), Expect = 2e-12
Identities = 103/408 (25%), Positives = 156/408 (38%), Gaps = 57/408 (13%)
Query: 59 LTLANRNLERLP-GCLPRT--LRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALR 115
L L +LE +P G L L+ N L +S HL LQVL L NR+ +
Sbjct: 154 LQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIP 213
Query: 116 WG----------------------PG---GPAGLHTLDLSYNQLAALPPCTGPALSSLRA 150
G PG L L LS N ++ LPP L L
Sbjct: 214 MGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNR 273
Query: 151 LALAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLD 210
L L GN L+ L F P L+ L L + + + F+ L L+VL
Sbjct: 274 LTLFGNSLKELSLGIFGPMPNLRELWLYDNHI-----SSLPDNVFSN-----LRQLQVLI 323
Query: 211 LSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVA 270
LS + + G L +L L L L L+G++F+M NLQ + Q++ L +
Sbjct: 324 LSRNQISFISPGAFNGLTELRELSLH-TNALQDLDGNVFRMLANLQNISLQNN-RLRQLP 381
Query: 271 THIFQDTPHLQVLLFQNCNLSSFPPWTLDS-SQVLSINLFGNPLTCSCDL----SWLLTD 325
+IF + L + QN L + P D ++ + L+ NP C D+ +WLL +
Sbjct: 382 GNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLN 441
Query: 326 AKRTVLSRAADTMCAPAAGSSGPFSASLSLS-QLPGVCQSDQSTTLGASHP--PCFNRST 382
R L +C A G ++++ +P V + S+P P + +
Sbjct: 442 QPR--LGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEV-----PSYPETPWYPDTP 494
Query: 383 YAQGTTVAPSAAPATRPAGDQQSVSKAPNVGSRTIAAWPHSDAREGTA 430
TT S T P D ++ R++ W + A+ G A
Sbjct: 495 SYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSV--WGMTQAQSGLA 540
Score = 48.5 bits (114), Expect = 2e-05
Identities = 60/216 (27%), Positives = 87/216 (40%), Gaps = 35/216 (16%)
Query: 122 AGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCTA 181
+ L L + N+L+ + P L SLR L+LA N L+ L F +L+ L LS
Sbjct: 77 SALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQ 136
Query: 182 LGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMP-- 239
L + I A F + L+ L L G LE + G L LT L L K
Sbjct: 137 LLQ-----IQPAHF-----SQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLT 186
Query: 240 ---------------------RLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTP 278
RLT + F NLQ+L Q + + ++ +F +
Sbjct: 187 HISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQN-QIGLLSPGLFHNNH 245
Query: 279 HLQVLLFQNCNLSSFPPWT-LDSSQVLSINLFGNPL 313
+LQ L N ++S PP + Q+ + LFGN L
Sbjct: 246 NLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSL 281
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 71.6 bits (174), Expect = 2e-12
Identities = 92/320 (28%), Positives = 129/320 (40%), Gaps = 22/320 (6%)
Query: 59 LTLANRNLERLPGCLPRTLRSLDASH---NLLRALSTSELGHLEQLQVLTLRHNRIAALR 115
LTL LE LP L + L +L++ H N L+AL L L+ L L N +A L
Sbjct: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185
Query: 116 WGPGGP-AGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFA---CFPA 171
P L TL LS N L+ LP L SL+ L L N + L P+ F+ C
Sbjct: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
Query: 172 LQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEV-----------LDLSGTFLERVE 220
L L + T L + F L L L L+ LE V
Sbjct: 246 LWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVA 305
Query: 221 SGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHL 280
G L L SL L +T L IF+ L +L S L ++ +FQ+ L
Sbjct: 306 EGTFAHLSNLRSLML-SYNAITHLPAGIFRDLEELVKLYL-GSNNLTALHPALFQNLSKL 363
Query: 281 QVLLFQNCNLSSFPPWTLDSS-QVLSINLFGNPLTCSCDLSWLLTDAKR-TVLSRAADTM 338
++L L++ P D++ + ++ L GNP C C L++L ++ T T
Sbjct: 364 ELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTY 423
Query: 339 CAPAAGSSGPFSASLSLSQL 358
CA A G +L+ QL
Sbjct: 424 CAGPAYLKGQVVPALNEKQL 443
Score = 47.4 bits (111), Expect = 5e-05
Identities = 49/163 (30%), Positives = 72/163 (44%), Gaps = 12/163 (7%)
Query: 124 LHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCTALG 183
L L L++N L ALP L++L +L L GN L+AL R F L+ LNL+ L
Sbjct: 123 LGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLA 182
Query: 184 RGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPRLTT 243
+ + E F PL +L+ L LS L + G L L L+L ++
Sbjct: 183 Q-----LPEELF-----HPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFL-DSNNISE 231
Query: 244 LEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQ 286
L +F L++L Q + A+ + IF +L L Q
Sbjct: 232 LPPQVFSQLFCLERLWLQRN-AITHLPLSIFASLGNLTFLSLQ 273
>gi|46094076 tsukushin [Homo sapiens]
Length = 353
Score = 71.2 bits (173), Expect = 3e-12
Identities = 81/271 (29%), Positives = 106/271 (39%), Gaps = 23/271 (8%)
Query: 55 DATALTLANRNLER-----LPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHN 109
D L L++ LE L G TL LD SHNLL ++S + L L+ L L HN
Sbjct: 59 DTAHLDLSSNRLEMVNESVLAGPGYTTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHN 118
Query: 110 RIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRAL--ALAGNPLRALQP---R 164
+ AL + L ++LS+NQL + S RAL L+ N + L P R
Sbjct: 119 GLTALPAESFTSSPLSDVNLSHNQLREVSVSAFTTHSQGRALHVDLSHNLIHRLVPHPTR 178
Query: 165 AFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWI 224
A P +Q LNL+ L A + + + L L L G L + G
Sbjct: 179 AGLPAPTIQSLNLAWNRL--HAVPNLRD-----------LPLRYLSLDGNPLAVIGPGAF 225
Query: 225 RDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLL 284
L LT L L + RL L F+ P LQ LD +P L +F LQ L
Sbjct: 226 AGLGGLTHLSLASLQRLPELAPSGFRELPGLQVLDLSGNPKLNWAGAEVFSGLSSLQELD 285
Query: 285 FQNCNLSSFPPWTLDSSQVLSINLFGNPLTC 315
NL P L L G + C
Sbjct: 286 LSGTNLVPLPEALLLHLPALQSVSVGQDVRC 316
>gi|12007646 nyctalopin precursor [Homo sapiens]
Length = 481
Score = 67.4 bits (163), Expect = 5e-11
Identities = 108/397 (27%), Positives = 150/397 (37%), Gaps = 68/397 (17%)
Query: 66 LERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGP-GGPAGL 124
L R+P LP S+D N LR L G L L+ L+LRHN ++ + G G L
Sbjct: 53 LLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRL 112
Query: 125 HTLDLSYN-QLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQ---------- 173
L L++N L L T ALS LR L LA L ++ R A PAL+
Sbjct: 113 AELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFR 172
Query: 174 --------LLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIR 225
L NL+ L RG +A ++ G L L L L + V +G
Sbjct: 173 RVPGALRGLANLTHAHLERGRIEAVASSSLQG-----LRRLRSLSLQANRVRAVHAGAFG 227
Query: 226 DLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLF 285
D L L L L L D F+ L+ L+ + AL VA F D L++L
Sbjct: 228 DCGVLEHLLLND-NLLAELPADAFRGLRRLRTLNLGGN-ALDRVARAWFADLAELELLYL 285
Query: 286 QN-----------CNLSSFPPWTLDSSQVL--------------SINLFGNPLTCSCDLS 320
NLS L+ +++ + LF NP C C L
Sbjct: 286 DRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLE 345
Query: 321 WLLTDAKRTVLSRAADTMCAPAAGSSGPFSASLSLSQL------PGVCQSDQSTTLGASH 374
WL + + R D CA +G L LSQ+ G+C + L S
Sbjct: 346 WLRDWMEGS--GRVTDVPCASPGSVAG-----LDLSQVTFGRSSDGLCVDPEELNLTTSS 398
Query: 375 PPCFNRSTYAQGTTVAPSAAPATRPAGDQQSVSKAPN 411
P S TTV+ ++ ++ + V +A N
Sbjct: 399 P---GPSPEPAATTVSRFSSLLSKLLAPRVPVEEAAN 432
Score = 33.5 bits (75), Expect = 0.73
Identities = 59/224 (26%), Positives = 85/224 (37%), Gaps = 17/224 (7%)
Query: 105 TLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPR 164
++R +R LR P ++DL N L L L SLR L+L N L + P
Sbjct: 45 SVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPG 104
Query: 165 AFACFPALQLLNL------------SCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLS 212
AF P L L L + AL R + +A L L L
Sbjct: 105 AFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALREL 164
Query: 213 GTF--LERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVA 270
F L R G +R L LT +L + R+ + + L+ L Q + + +V
Sbjct: 165 AAFDNLFRRVPGALRGLANLTHAHLER-GRIEAVASSSLQGLRRLRSLSLQ-ANRVRAVH 222
Query: 271 THIFQDTPHLQVLLFQNCNLSSFPPWTLDSSQVL-SINLFGNPL 313
F D L+ LL + L+ P + L ++NL GN L
Sbjct: 223 AGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNAL 266
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 67.0 bits (162), Expect = 6e-11
Identities = 98/354 (27%), Positives = 136/354 (38%), Gaps = 71/354 (20%)
Query: 43 ATDSPCEGLPA-----ADATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGH 97
A P G PA A+ R L +P +P R L+ S N +R L+ +L
Sbjct: 17 AAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAA 76
Query: 98 LEQLQVLTLRHNRIAALRWGPGG------------------PAGLHT-------LDLSYN 132
L L+ L L N IA + G P G+ T LDLS N
Sbjct: 77 LPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSEN 136
Query: 133 QLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNL---SCTALGRGAQGG 189
+L L T L SLR L + N L + RAFA AL+ L L + TAL + G
Sbjct: 137 KLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGH 196
Query: 190 I-----------AEAAFAGEDGAPLVTLEVLDLSG-TFLERVESGWIRDLPKLTSLY--- 234
+ A A+ ++ L L L++ LE V +G +R L LTSL
Sbjct: 197 LRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGL-NLTSLSVTH 255
Query: 235 ----------LRKMPRLT----------TLEGDIFKMTPNLQQLDCQDSPALASVATHIF 274
LR LT T+ F+ L++L + LA V F
Sbjct: 256 TNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGA-LLAVVEPQAF 314
Query: 275 QDTPHLQVLLFQNCNLSSFPPWTLDSSQVL-SINLFGNPLTCSCDLSWLLTDAK 327
+++L N LS+ T S L ++ + GNPL C C L W++ K
Sbjct: 315 LGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRK 368
>gi|219521831 adhesion molecule with Ig-like domain 2 [Homo sapiens]
Length = 522
Score = 66.2 bits (160), Expect = 1e-10
Identities = 60/177 (33%), Positives = 81/177 (45%), Gaps = 12/177 (6%)
Query: 4 TLPLLLLTVLRPSWADPPQEKVPLFRVTQQGPWGSSGSNATDSPCEGLPAADATALTLAN 63
TLP LL V+RP +E + L +T G+SG T C A D + T N
Sbjct: 7 TLPTLLGAVVRPGC----RELLCLLMITVTVGPGASGVCPTACIC----ATDIVSCT--N 56
Query: 64 RNLERLPGCLPRTLRSLDASHNLLRALSTSELG-HLEQLQVLTLRHNRIAALRWGPGGPA 122
+NL ++PG L R ++ LD S+N + L + + +L L LRHN I ++ G
Sbjct: 57 KNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTT 116
Query: 123 -GLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLS 178
L LDLS N+L + L L L L N + L P AF LQ L LS
Sbjct: 117 PNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLS 173
Score = 30.8 bits (68), Expect = 4.7
Identities = 37/126 (29%), Positives = 54/126 (42%), Gaps = 11/126 (8%)
Query: 38 SSGSNATDSPCEGLPAADATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGH 97
S+GS +T + L + T+ N + L + L L +N + L S G
Sbjct: 109 STGSFSTTPNLKCLDLSSNKLKTVKNAVFQEL-----KVLEVLLLYNNHISYLDPSAFGG 163
Query: 98 LEQLQVLTLRHNRIAA----LRWGPGGPAGLHTLDLSYNQLAALPPCTGPAL--SSLRAL 151
L QLQ L L N + L G A L LD+SYN++ ++P + LR +
Sbjct: 164 LSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGI 223
Query: 152 ALAGNP 157
L GNP
Sbjct: 224 YLHGNP 229
>gi|32469517 adhesion molecule with Ig-like domain 2 [Homo sapiens]
Length = 522
Score = 66.2 bits (160), Expect = 1e-10
Identities = 60/177 (33%), Positives = 81/177 (45%), Gaps = 12/177 (6%)
Query: 4 TLPLLLLTVLRPSWADPPQEKVPLFRVTQQGPWGSSGSNATDSPCEGLPAADATALTLAN 63
TLP LL V+RP +E + L +T G+SG T C A D + T N
Sbjct: 7 TLPTLLGAVVRPGC----RELLCLLMITVTVGPGASGVCPTACIC----ATDIVSCT--N 56
Query: 64 RNLERLPGCLPRTLRSLDASHNLLRALSTSELG-HLEQLQVLTLRHNRIAALRWGPGGPA 122
+NL ++PG L R ++ LD S+N + L + + +L L LRHN I ++ G
Sbjct: 57 KNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTT 116
Query: 123 -GLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLS 178
L LDLS N+L + L L L L N + L P AF LQ L LS
Sbjct: 117 PNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLS 173
Score = 30.8 bits (68), Expect = 4.7
Identities = 37/126 (29%), Positives = 54/126 (42%), Gaps = 11/126 (8%)
Query: 38 SSGSNATDSPCEGLPAADATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGH 97
S+GS +T + L + T+ N + L + L L +N + L S G
Sbjct: 109 STGSFSTTPNLKCLDLSSNKLKTVKNAVFQEL-----KVLEVLLLYNNHISYLDPSAFGG 163
Query: 98 LEQLQVLTLRHNRIAA----LRWGPGGPAGLHTLDLSYNQLAALPPCTGPAL--SSLRAL 151
L QLQ L L N + L G A L LD+SYN++ ++P + LR +
Sbjct: 164 LSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGI 223
Query: 152 ALAGNP 157
L GNP
Sbjct: 224 YLHGNP 229
>gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens]
Length = 504
Score = 65.5 bits (158), Expect = 2e-10
Identities = 64/187 (34%), Positives = 75/187 (40%), Gaps = 11/187 (5%)
Query: 56 ATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALR 115
A L+ L+ +P LP LD SHN L+ L L L QL+ L L HN + AL
Sbjct: 42 ADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALG 101
Query: 116 WGP-GGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQL 174
G +GL LDLS N L AL L +L L L N L L AF AL
Sbjct: 102 RGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSH 161
Query: 175 LNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKL--TS 232
L L C L A +F G L LDLS L + + LP
Sbjct: 162 LYLGCNEL--------ASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNG 213
Query: 233 LYLRKMP 239
LYL P
Sbjct: 214 LYLHNNP 220
Score = 37.0 bits (84), Expect = 0.066
Identities = 61/219 (27%), Positives = 73/219 (33%), Gaps = 37/219 (16%)
Query: 121 PAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCT 180
PA LDLS+N L L P L LRAL L N L AL F L+LL+LS
Sbjct: 60 PAATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSN 119
Query: 181 ALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPR 240
L A D L LE L L L ++ L L+ LYL
Sbjct: 120 TL----------RALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYL----- 164
Query: 241 LTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTLDS 300
C + + + H T HL L + L L +
Sbjct: 165 ------------------GCNELASFSFDHLHGLSAT-HLLTLDLSSNRLGHISVPELAA 205
Query: 301 SQVLSIN---LFGNPLTCSCDLSWLLTDAKRTVLSRAAD 336
N L NPL C C L LL + LS D
Sbjct: 206 LPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLSAVRD 244
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 65.5 bits (158), Expect = 2e-10
Identities = 72/252 (28%), Positives = 113/252 (44%), Gaps = 24/252 (9%)
Query: 80 LDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGPGGP----AGLHTLDLSYNQLA 135
L HN + + L +L+ L L N+I L P L LDLS+NQL+
Sbjct: 90 LHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYL---PNTTFTQLINLQNLDLSFNQLS 146
Query: 136 ALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAF 195
+L P L L+ L L N LR + R F +L+ L+LS L A+ G F
Sbjct: 147 SLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNG-----F 201
Query: 196 AGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNL 255
AG L+ L L L L ++ L L +L+L + +++ L + L
Sbjct: 202 AG-----LIKLRELHLEHNQLTKINFAHFLRLSSLHTLFL-QWNKISNLTCGMEWTWGTL 255
Query: 256 QQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTLDSSQVL-SINLFGNPLT 314
++LD + + ++ +F+ P+L++LL N L+S L+S + L ++ L GN
Sbjct: 256 EKLDLTGN-EIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWE 314
Query: 315 CSCDL----SWL 322
CS + SWL
Sbjct: 315 CSARICALASWL 326
Score = 39.3 bits (90), Expect = 0.013
Identities = 29/103 (28%), Positives = 47/103 (45%), Gaps = 1/103 (0%)
Query: 77 LRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGPGGPAG-LHTLDLSYNQLA 135
LR L HN L ++ + L L L L+ N+I+ L G G L LDL+ N++
Sbjct: 207 LRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIK 266
Query: 136 ALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLS 178
A+ + +L+ L + N L +L + +L + LS
Sbjct: 267 AIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLS 309
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 65.5 bits (158), Expect = 2e-10
Identities = 69/228 (30%), Positives = 104/228 (45%), Gaps = 21/228 (9%)
Query: 61 LANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGPGG 120
L N LER+P LPR +R+L HN + + + L+ L L +NRI + +
Sbjct: 414 LYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDA 473
Query: 121 PAG---LHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNL 177
L +LDLS N+L LPP ++ L + N L AL A L+ L L
Sbjct: 474 FRKLRLLRSLDLSGNRLHTLPP---GLPRNVHVLKVKRNELAALARGALVGMAQLRELYL 530
Query: 178 SCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPK-LTSLYLR 236
+ L A G A L L++LD++G L + G LP+ L LYL+
Sbjct: 531 TSNRLRSRALGPRA--------WVDLAHLQLLDIAGNQLTEIPEG----LPESLEYLYLQ 578
Query: 237 KMPRLTTLEGDIFKMTPNLQQLDCQ-DSPALASVATHIFQDTPHLQVL 283
+++ + + F TPNL+ + + + A+ SV F+ HLQVL
Sbjct: 579 N-NKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVL 625
Score = 55.8 bits (133), Expect = 1e-07
Identities = 52/159 (32%), Positives = 72/159 (45%), Gaps = 14/159 (8%)
Query: 58 ALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWG 117
+L L+ L LP LPR + L N L AL+ L + QL+ L L NR+ + G
Sbjct: 482 SLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALG 541
Query: 118 PGG---PAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQL 174
P A L LD++ NQL +P SL L L N + A+ AF P L+
Sbjct: 542 PRAWVDLAHLQLLDIAGNQLTEIPE---GLPESLEYLYLQNNKISAVPANAFDSTPNLKG 598
Query: 175 LNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSG 213
+ L L A G + ++AF L L+VLD+ G
Sbjct: 599 IFLRFNKL---AVGSVVDSAF-----RRLKHLQVLDIEG 629
Score = 49.7 bits (117), Expect = 1e-05
Identities = 70/276 (25%), Positives = 108/276 (39%), Gaps = 22/276 (7%)
Query: 22 QEKVPLFRVTQQGPWGSSGSNATDSPCEGLPAADATALTLANRNLERLPGCLPRTLRSLD 81
+E V + + GP ++ S D C D + +L PG LP L
Sbjct: 96 EEPVLVLSPEEPGPGPAAVSCPRDCACSQEGVVDCGGI-----DLREFPGDLPEHTNHLS 150
Query: 82 ASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCT 141
+N L + EL L +L+ L L++NR+ + G A H +L+Y LA
Sbjct: 151 LQNNQLEKIYPEELSRLHRLETLNLQNNRLTSR--GLPEKAFEHLTNLNYLYLANNKLTL 208
Query: 142 GPAL--SSLRALALAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGED 199
P ++L ++ A N L + F P L+ + L L A G+ + F G
Sbjct: 209 APRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKL---ADAGLPDNMFNGSS 265
Query: 200 GAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLD 259
+EVL LS FL V P L L+L K +L + F +L++L
Sbjct: 266 -----NVEVLILSSNFLRHVPK---HLPPALYKLHL-KNNKLEKIPPGAFSELSSLRELY 316
Query: 260 CQDSPAL-ASVATHIFQDTPHLQVLLFQNCNLSSFP 294
Q++ + F L+ L + NLS P
Sbjct: 317 LQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVP 352
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 65.1 bits (157), Expect = 2e-10
Identities = 63/278 (22%), Positives = 112/278 (40%), Gaps = 41/278 (14%)
Query: 33 QGPWGSSGSNATDSPCEGLPAADATALTLANRNLERLPGCLPRTLRSLDASHNLLRALST 92
+G G A + PC L + + L RLP LP + LD SHN L +
Sbjct: 32 RGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKA 91
Query: 93 SELGHLEQLQVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALA 152
S + HL+ L+ + L +N + + P GP +++ L+
Sbjct: 92 SSMSHLQSLREVKLNNNELETI------------------------PNLGPVSANITLLS 127
Query: 153 LAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLS 212
LAGN + + P F +L+ L+LS + + AF P + L+ L L+
Sbjct: 128 LAGNRIVEILPEHLKEFQSLETLDLSSNNISE------LQTAF------PALQLKYLYLN 175
Query: 213 GTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATH 272
+ +E G+ +L + R++ + +FK+ P LQ L+ + + +V
Sbjct: 176 SNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKL-PQLQHLELNRN-KIKNVDGL 233
Query: 273 IFQDTPHLQVLLFQNCNLSSFPP---WTLDSSQVLSIN 307
FQ L+ L Q ++ W L + ++L ++
Sbjct: 234 TFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLD 271
Score = 46.6 bits (109), Expect = 8e-05
Identities = 63/247 (25%), Positives = 92/247 (37%), Gaps = 33/247 (13%)
Query: 77 LRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWG-PGGPAGLHTLDLSYNQLA 135
L+SL N + L L +++L L HN + + G G L L LS N +
Sbjct: 241 LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 300
Query: 136 ALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAF 195
+ P L L L N L L +F L L++ G IA+ AF
Sbjct: 301 RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHI-----GNNRVSYIADCAF 355
Query: 196 AGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNL 255
G + L+ ++S T + +G L KL L L+ R+ ++ F L
Sbjct: 356 RGLSSLKTLDLKNNEISWTIEDM--NGAFSGLDKLRRLILQGN-RIRSITKKAFTGLDAL 412
Query: 256 QQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTLDSSQVLSINLFGNPLTC 315
+ LD D+ A+ S+ + F LQ L + N SS L C
Sbjct: 413 EHLDLSDN-AIMSLQGNAFSQMKKLQQL---HLNTSS--------------------LLC 448
Query: 316 SCDLSWL 322
C L WL
Sbjct: 449 DCQLKWL 455
>gi|193083139 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 65.1 bits (157), Expect = 2e-10
Identities = 86/328 (26%), Positives = 123/328 (37%), Gaps = 54/328 (16%)
Query: 20 PPQEKVPLFRVTQQGPWGSSGSNATDSPCEGLPAADATALTLANRNLERLPGCLPRTLRS 79
PPQ+ + ++ W + +A G P + L L+ +E +P L S
Sbjct: 283 PPQDSKGIHAPSEG--WSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTS 340
Query: 80 L---DASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAA 136
L + S N LR LG L L +L L HN + L G L TL L N L
Sbjct: 341 LCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRD 400
Query: 137 LPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFA 196
LPP T L+SL+ L L GN R C G G AF+
Sbjct: 401 LPPYTFANLASLQRLNLQGN-------RVSPCG-------------GPDEPGPSGCVAFS 440
Query: 197 GEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQ 256
G + +L L L +E + +G P LT L L P L G + + +L+
Sbjct: 441 G-----ITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLE 494
Query: 257 QLDCQ---------DSPALASV---------ATHI--FQDTPHLQVLLFQNCNLSSFPPW 296
L Q D P + +H+ + L+VL +N + S P
Sbjct: 495 VLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGS 554
Query: 297 TLD--SSQVLSINLFGNPLTCSCDLSWL 322
+ + + + L GNPL+C C WL
Sbjct: 555 AMGGLETSLRRLYLQGNPLSC-CGNGWL 581
Score = 57.0 bits (136), Expect = 6e-08
Identities = 61/192 (31%), Positives = 88/192 (45%), Gaps = 18/192 (9%)
Query: 121 PAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCT 180
P TLDLS NQL ++ ++LR L L+ N + LQP AF L+ L+L+
Sbjct: 48 PPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHN 107
Query: 181 ALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGT-----FLERVESGWIRDLPKLTSLYL 235
L +A A AG G PL + LDLSG LER+ + + P L +L L
Sbjct: 108 RL------AMATALSAGGLG-PLPRVTSLDLSGNSLYSGLLERL----LGEAPSLHTLSL 156
Query: 236 RKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPP 295
+ LT L F+ P L+QLD S L + F+ P L L +L+
Sbjct: 157 AE-NSLTRLTRHTFRDMPALEQLDLH-SNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISD 214
Query: 296 WTLDSSQVLSIN 307
++L +VL ++
Sbjct: 215 FSLQQLRVLDLS 226
Score = 49.7 bits (117), Expect = 1e-05
Identities = 64/185 (34%), Positives = 79/185 (42%), Gaps = 14/185 (7%)
Query: 7 LLLLTVLRPSWADPPQEKVPLFRVTQQGPWGSSGSNATDSPCEGLPAADATALTLANRNL 66
LLLL +L A Q+KVP V ++ G S LP D L L+ L
Sbjct: 6 LLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSV---LPP-DTETLDLSGNQL 61
Query: 67 ERL---PGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIA---ALRWGPGG 120
+ P LR LD S N + L L L+ L+L HNR+A AL G G
Sbjct: 62 RSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLG 121
Query: 121 P-AGLHTLDLSYNQL--AALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNL 177
P + +LDLS N L L G A SL L+LA N L L F PAL+ L+L
Sbjct: 122 PLPRVTSLDLSGNSLYSGLLERLLGEA-PSLHTLSLAENSLTRLTRHTFRDMPALEQLDL 180
Query: 178 SCTAL 182
L
Sbjct: 181 HSNVL 185
>gi|5031707 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 65.1 bits (157), Expect = 2e-10
Identities = 86/328 (26%), Positives = 123/328 (37%), Gaps = 54/328 (16%)
Query: 20 PPQEKVPLFRVTQQGPWGSSGSNATDSPCEGLPAADATALTLANRNLERLPGCLPRTLRS 79
PPQ+ + ++ W + +A G P + L L+ +E +P L S
Sbjct: 283 PPQDSKGIHAPSEG--WSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTS 340
Query: 80 L---DASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAA 136
L + S N LR LG L L +L L HN + L G L TL L N L
Sbjct: 341 LCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRD 400
Query: 137 LPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFA 196
LPP T L+SL+ L L GN R C G G AF+
Sbjct: 401 LPPYTFANLASLQRLNLQGN-------RVSPCG-------------GPDEPGPSGCVAFS 440
Query: 197 GEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQ 256
G + +L L L +E + +G P LT L L P L G + + +L+
Sbjct: 441 G-----ITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLE 494
Query: 257 QLDCQ---------DSPALASV---------ATHI--FQDTPHLQVLLFQNCNLSSFPPW 296
L Q D P + +H+ + L+VL +N + S P
Sbjct: 495 VLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGS 554
Query: 297 TLD--SSQVLSINLFGNPLTCSCDLSWL 322
+ + + + L GNPL+C C WL
Sbjct: 555 AMGGLETSLRRLYLQGNPLSC-CGNGWL 581
Score = 57.0 bits (136), Expect = 6e-08
Identities = 61/192 (31%), Positives = 88/192 (45%), Gaps = 18/192 (9%)
Query: 121 PAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCT 180
P TLDLS NQL ++ ++LR L L+ N + LQP AF L+ L+L+
Sbjct: 48 PPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHN 107
Query: 181 ALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGT-----FLERVESGWIRDLPKLTSLYL 235
L +A A AG G PL + LDLSG LER+ + + P L +L L
Sbjct: 108 RL------AMATALSAGGLG-PLPRVTSLDLSGNSLYSGLLERL----LGEAPSLHTLSL 156
Query: 236 RKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPP 295
+ LT L F+ P L+QLD S L + F+ P L L +L+
Sbjct: 157 AE-NSLTRLTRHTFRDMPALEQLDLH-SNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISD 214
Query: 296 WTLDSSQVLSIN 307
++L +VL ++
Sbjct: 215 FSLQQLRVLDLS 226
Score = 49.7 bits (117), Expect = 1e-05
Identities = 64/185 (34%), Positives = 79/185 (42%), Gaps = 14/185 (7%)
Query: 7 LLLLTVLRPSWADPPQEKVPLFRVTQQGPWGSSGSNATDSPCEGLPAADATALTLANRNL 66
LLLL +L A Q+KVP V ++ G S LP D L L+ L
Sbjct: 6 LLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSV---LPP-DTETLDLSGNQL 61
Query: 67 ERL---PGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIA---ALRWGPGG 120
+ P LR LD S N + L L L+ L+L HNR+A AL G G
Sbjct: 62 RSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLG 121
Query: 121 P-AGLHTLDLSYNQL--AALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNL 177
P + +LDLS N L L G A SL L+LA N L L F PAL+ L+L
Sbjct: 122 PLPRVTSLDLSGNSLYSGLLERLLGEA-PSLHTLSLAENSLTRLTRHTFRDMPALEQLDL 180
Query: 178 SCTAL 182
L
Sbjct: 181 HSNVL 185
>gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
sapiens]
Length = 522
Score = 64.3 bits (155), Expect = 4e-10
Identities = 80/289 (27%), Positives = 121/289 (41%), Gaps = 23/289 (7%)
Query: 42 NATDSP--CEGLPAADATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLE 99
N T++P GL +L+ + G + T LD HN + ++ L
Sbjct: 56 NLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLD--HNHICSVQGDAFQKLR 113
Query: 100 QLQVLTLRHNRIAALRWGPGGPA-GLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPL 158
+++ LTL N+I L P L ++DLSYN+L AL P L L L + N +
Sbjct: 114 RVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAI 173
Query: 159 RALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLER 218
+ + R F +L+ L+ +G +A +FAG L L L L L +
Sbjct: 174 QFVPVRIFQDCRSLKFLD-----IGYNQLKSLARNSFAG-----LFKLTELHLEHNDLVK 223
Query: 219 VESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTP 278
V L L SL LR+ + NL+++D + + + H+F+ P
Sbjct: 224 VNFAHFPRLISLHSLCLRR--NKVAIVVSSLDWVWNLEKMDLSGN-EIEYMEPHVFETVP 280
Query: 279 HLQVLLFQNCNLSSFPPWTLDS-SQVLSINLFGNPLTCS---CDL-SWL 322
HLQ L + L+ P L+S + SI L GN C C L SWL
Sbjct: 281 HLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWL 329
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,185,410
Number of Sequences: 37866
Number of extensions: 1649437
Number of successful extensions: 8399
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 338
Number of HSP's that attempted gapping in prelim test: 6170
Number of HSP's gapped (non-prelim): 1868
length of query: 740
length of database: 18,247,518
effective HSP length: 110
effective length of query: 630
effective length of database: 14,082,258
effective search space: 8871822540
effective search space used: 8871822540
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.