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Search of human proteins with 113412837
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|113412837 PREDICTED: similar to unr-interacting protein
[Homo sapiens]
(348 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|113412837 PREDICTED: similar to unr-interacting protein [Homo... 715 0.0
gi|239753142 PREDICTED: similar to unr-interacting protein [Homo... 706 0.0
gi|239747708 PREDICTED: similar to unr-interacting protein [Homo... 706 0.0
gi|148727341 serine/threonine kinase receptor associated protein... 615 e-176
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 74 3e-13
gi|4503513 eukaryotic translation initiation factor 3, subunit 2... 71 2e-12
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 69 6e-12
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 68 1e-11
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 68 1e-11
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 68 1e-11
gi|26665869 WD repeat domain 51B [Homo sapiens] 64 3e-10
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 62 1e-09
gi|32189425 WD repeat domain 69 [Homo sapiens] 61 1e-09
gi|21071067 TBP-associated factor 5 [Homo sapiens] 60 2e-09
gi|113865883 WD repeat domain 38 [Homo sapiens] 60 2e-09
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 60 4e-09
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 60 4e-09
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 58 1e-08
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 57 2e-08
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 57 3e-08
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 57 3e-08
gi|16554629 WD repeat domain 5 [Homo sapiens] 55 7e-08
gi|16554627 WD repeat domain 5 [Homo sapiens] 55 7e-08
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 55 7e-08
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 55 1e-07
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 55 1e-07
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 52 8e-07
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 50 2e-06
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 50 2e-06
gi|18874090 WD repeat domain 48 [Homo sapiens] 50 4e-06
>gi|113412837 PREDICTED: similar to unr-interacting protein [Homo
sapiens]
Length = 348
Score = 715 bits (1846), Expect = 0.0
Identities = 348/348 (100%), Positives = 348/348 (100%)
Query: 1 MAMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKG 60
MAMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKG
Sbjct: 1 MAMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKG 60
Query: 61 AVWGATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQDK 120
AVWGATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQDK
Sbjct: 61 AVWGATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQDK 120
Query: 121 LLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKSLN 180
LLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKSLN
Sbjct: 121 LLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKSLN 180
Query: 181 FNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLVAG 240
FNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLVAG
Sbjct: 181 FNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLVAG 240
Query: 241 GEDFKLYKYFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGL 300
GEDFKLYKYFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGL
Sbjct: 241 GEDFKLYKYFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGL 300
Query: 301 WKCVLPEEESGELAKPKIGFPETTEEELEEIVSEDSDCIYSSTPDVKA 348
WKCVLPEEESGELAKPKIGFPETTEEELEEIVSEDSDCIYSSTPDVKA
Sbjct: 301 WKCVLPEEESGELAKPKIGFPETTEEELEEIVSEDSDCIYSSTPDVKA 348
>gi|239753142 PREDICTED: similar to unr-interacting protein [Homo
sapiens]
Length = 347
Score = 706 bits (1823), Expect = 0.0
Identities = 346/348 (99%), Positives = 346/348 (99%), Gaps = 1/348 (0%)
Query: 1 MAMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKG 60
MAMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKG
Sbjct: 1 MAMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKG 60
Query: 61 AVWGATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQDK 120
AVWGATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQDK
Sbjct: 61 AVWGATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQDK 120
Query: 121 LLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKSLN 180
LLRMYDLNKPKARPKEISGHTSGIKK L WCSEDKQILSADDKTARLWDHATMTEVKSLN
Sbjct: 121 LLRMYDLNKPKARPKEISGHTSGIKKGL-WCSEDKQILSADDKTARLWDHATMTEVKSLN 179
Query: 181 FNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLVAG 240
FNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLVAG
Sbjct: 180 FNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLVAG 239
Query: 241 GEDFKLYKYFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGL 300
GEDFKLYKYFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGL
Sbjct: 240 GEDFKLYKYFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGL 299
Query: 301 WKCVLPEEESGELAKPKIGFPETTEEELEEIVSEDSDCIYSSTPDVKA 348
WKCVLPEEESGELAKPKIGFPETTEEELEEIVSEDSDCIYSSTPDVKA
Sbjct: 300 WKCVLPEEESGELAKPKIGFPETTEEELEEIVSEDSDCIYSSTPDVKA 347
>gi|239747708 PREDICTED: similar to unr-interacting protein [Homo
sapiens]
Length = 347
Score = 706 bits (1823), Expect = 0.0
Identities = 346/348 (99%), Positives = 346/348 (99%), Gaps = 1/348 (0%)
Query: 1 MAMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKG 60
MAMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKG
Sbjct: 1 MAMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKG 60
Query: 61 AVWGATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQDK 120
AVWGATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQDK
Sbjct: 61 AVWGATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQDK 120
Query: 121 LLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKSLN 180
LLRMYDLNKPKARPKEISGHTSGIKK L WCSEDKQILSADDKTARLWDHATMTEVKSLN
Sbjct: 121 LLRMYDLNKPKARPKEISGHTSGIKKGL-WCSEDKQILSADDKTARLWDHATMTEVKSLN 179
Query: 181 FNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLVAG 240
FNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLVAG
Sbjct: 180 FNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLVAG 239
Query: 241 GEDFKLYKYFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGL 300
GEDFKLYKYFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGL
Sbjct: 240 GEDFKLYKYFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGL 299
Query: 301 WKCVLPEEESGELAKPKIGFPETTEEELEEIVSEDSDCIYSSTPDVKA 348
WKCVLPEEESGELAKPKIGFPETTEEELEEIVSEDSDCIYSSTPDVKA
Sbjct: 300 WKCVLPEEESGELAKPKIGFPETTEEELEEIVSEDSDCIYSSTPDVKA 347
>gi|148727341 serine/threonine kinase receptor associated protein
[Homo sapiens]
Length = 350
Score = 615 bits (1586), Expect = e-176
Identities = 312/351 (88%), Positives = 322/351 (91%), Gaps = 4/351 (1%)
Query: 1 MAMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKG 60
MAMRQT LT GHT P+VDLAFSGIT YGYFL SA KDGKPMLRQGDTGDWIGTF GHKG
Sbjct: 1 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKG 60
Query: 61 AVWGATLN--ATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQ 118
AVWGATLN ATKAATAAADFTAKVWDAV GDELMTLAHK+IVKTV F QDSNYLLT GQ
Sbjct: 61 AVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQ 120
Query: 119 DKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKS 178
DKLLR+YDLNKP+A PKEISGHTSGIKK L WCSEDKQILSADDKT RLWDHATMTEVKS
Sbjct: 121 DKLLRIYDLNKPEAEPKEISGHTSGIKKAL-WCSEDKQILSADDKTVRLWDHATMTEVKS 179
Query: 179 LNFNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLV 238
LNFNMSVSS +YIPEGEILVITYG SIAFHSAVSLDPI SFEAPATINSASLHPEKEFLV
Sbjct: 180 LNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLV 239
Query: 239 AGGEDFKLYKY-FNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKT 297
AGGEDFKLYKY +N GEE ESYKG+FGPIHCVRFS DGELYASGSEDGTLRL QTVVGKT
Sbjct: 240 AGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKT 299
Query: 298 YGLWKCVLPEEESGELAKPKIGFPETTEEELEEIVSEDSDCIYSSTPDVKA 348
YGLWKCVLPEE+SGELAKPKIGFPETTEEELEEI SE+SDCI+ S PDVKA
Sbjct: 300 YGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA 350
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 73.6 bits (179), Expect = 3e-13
Identities = 57/222 (25%), Positives = 96/222 (43%), Gaps = 5/222 (2%)
Query: 71 KAATAAADFTAKVWDAVLGDELMTL-AHKYIVKTVYFMQDSNYLLTKGQDKLLRMYDLNK 129
K AT++ D T K+WD GD ++T H V + + N++ + DK +++D+N
Sbjct: 408 KLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNS 467
Query: 130 PKARPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKSLNFNM-SVSST 188
+ R + GHT + + + + S+ DKT +WD T +SL +M S++
Sbjct: 468 ERCRCT-LYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDA 526
Query: 189 KYIPEGEILVITYGLSIA-FHSAVSLDPITSFE-APATINSASLHPEKEFLVAGGEDFKL 246
+ P G ++ + L PI S + P+ N + L + +
Sbjct: 527 IFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVI 586
Query: 247 YKYFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLR 288
+ E G+ H V FS DGE+ SG DGT+R
Sbjct: 587 HLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVR 628
Score = 32.3 bits (72), Expect = 0.65
Identities = 27/103 (26%), Positives = 44/103 (42%), Gaps = 8/103 (7%)
Query: 67 LNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQDKLLRMYD 126
LN +K + + A F K+ + + H+ V V + L++ G+D+L ++
Sbjct: 328 LNVSKESLSPAKFDYKLKN-------IFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLG 380
Query: 127 LNKPKARPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLWD 169
L K GHT + S DK S+ D T +LWD
Sbjct: 381 LPKCNVLLTGF-GHTDWLSDCCFHPSGDKLATSSGDTTVKLWD 422
>gi|4503513 eukaryotic translation initiation factor 3, subunit 2
beta, 36kDa [Homo sapiens]
Length = 325
Score = 70.9 bits (172), Expect = 2e-12
Identities = 66/276 (23%), Positives = 110/276 (39%), Gaps = 41/276 (14%)
Query: 49 GDWIGTFWGHKGAVW--GATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYF 106
G+ +GT+ GH GAVW A + T +AD + ++WD G +L L V+T F
Sbjct: 42 GERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGF 101
Query: 107 MQDSNYLLTK-----GQDKLLRMYDLNKPKAR---------PKEISGHTSGIKKRLLWC- 151
N ++ G + +DL P P S TS + L C
Sbjct: 102 DFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECI 161
Query: 152 ---SEDKQILSADDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFH 208
E ++ K+ + + + + +S T ++ + +
Sbjct: 162 IAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASK------DNTAKLF 215
Query: 209 SAVSLDPITSFEAPATINSASLHPEKEFLVAGGEDFKL---------------YKYFNHG 253
+ +L+ +F +NSA+L P + +V GG + + +
Sbjct: 216 DSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFE 275
Query: 254 EEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRL 289
EEF KG+FGPI+ V F DG+ Y+SG EDG +R+
Sbjct: 276 EEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
Score = 50.1 bits (118), Expect = 3e-06
Identities = 52/218 (23%), Positives = 97/218 (44%), Gaps = 27/218 (12%)
Query: 92 LMTLAHKYIVKTVYFMQDSNYLLTKGQDKLLRM-YDLNKPKARPKEISGHTSGIKKRLLW 150
++ H+ + + + ++ + L T +D ++ + Y +N R GHT + W
Sbjct: 4 ILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGE--RLGTYMGHTGAV-----W 56
Query: 151 CSE----DKQILSAD-DKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSI 205
C + K +L+ D + RLWD T ++ L N +V + + G I++ + +
Sbjct: 57 CVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQM 116
Query: 206 AFHSAVSL----DP--ITSFEA-------PATINSASLHPEKEFLVAGGEDFKLYKYF-N 251
+ VS DP I + E + I SA P E ++AG E +L +Y
Sbjct: 117 GYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAK 176
Query: 252 HGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRL 289
GE + K + I+ ++ SRD ++ + S+D T +L
Sbjct: 177 SGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKL 214
Score = 32.7 bits (73), Expect = 0.49
Identities = 18/54 (33%), Positives = 25/54 (46%)
Query: 249 YFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGLWK 302
Y +GE +Y G+ G + CV D + +GS D + RL GK L K
Sbjct: 38 YSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLK 91
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 68.9 bits (167), Expect = 6e-12
Identities = 59/220 (26%), Positives = 99/220 (45%), Gaps = 6/220 (2%)
Query: 74 TAAADFTAKVWDAVLGDELMTLA-HKYIVKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKA 132
T +AD T K+WD G ++L H V+ V S YL + G+DK ++ +DL K
Sbjct: 221 TGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKV 280
Query: 133 RPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKSLNFNMSVSSTKYIP 192
+ GH S + L + D + + D TAR+WD T V +L+ + + +T
Sbjct: 281 I-RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQ 339
Query: 193 EGEILVIT--YGLSIAFHSAVS-LDPITSFEAPATINSASLHPEKEFLVAGGEDFKLYKY 249
E +IT + +I V+ +T ++ + LHP +G D
Sbjct: 340 AAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWK 399
Query: 250 FNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRL 289
F G ++ G+ I+ + + DG L SG+++GT+ L
Sbjct: 400 FPDGSFIQNLSGHNAIINTLTVNSDGVL-VSGADNGTMHL 438
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 67.8 bits (164), Expect = 1e-11
Identities = 64/244 (26%), Positives = 106/244 (43%), Gaps = 22/244 (9%)
Query: 55 FWGHKGAVWGATLNATK--AATAAADFTAKVW-DAVLGDELMTLAHKYIVKTVYFMQDSN 111
F GHK AV + + A+ + D T ++W V G+ + AH V++V+F D
Sbjct: 19 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQ 78
Query: 112 YLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQIL--SADDKTARLWD 169
+T DK ++++ ++ K +S H + + R S D +++ ++DDKT +LWD
Sbjct: 79 SFVTASDDKTVKVWATHRQKFL-FSLSQHINWV--RCAKFSPDGRLIVSASDDKTVKLWD 135
Query: 170 HATMTEVKSL-NFNMSVSSTKYIPEGEILVITYGLS-------IAFHSAVSLDPITSFEA 221
++ V S V+ + P G + G+ + H + + S
Sbjct: 136 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAA-GMDNTVKVWDVRTHRLLQHYQLHS--- 191
Query: 222 PATINSASLHPEKEFLVAGGEDFKLYKY-FNHGEEFESYKGYFGPIHCVRFSRDGELYAS 280
A +N S HP +L+ D L G + G+ GP V FSR GE +AS
Sbjct: 192 -AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS 250
Query: 281 GSED 284
G D
Sbjct: 251 GGSD 254
Score = 34.7 bits (78), Expect = 0.13
Identities = 19/68 (27%), Positives = 33/68 (48%), Gaps = 1/68 (1%)
Query: 223 ATINSASLHPEKEFLVAGGEDFKLYKYFNHGEEFE-SYKGYFGPIHCVRFSRDGELYASG 281
AT+ S + + V +D + + H ++F S + + C +FS DG L S
Sbjct: 66 ATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSA 125
Query: 282 SEDGTLRL 289
S+D T++L
Sbjct: 126 SDDKTVKL 133
Score = 32.0 bits (71), Expect = 0.84
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 259 YKGYFGPIHCVRFSRDGELYASGSEDGTLRL 289
+ G+ + CV FS G L ASGS D T+R+
Sbjct: 19 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRI 49
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 67.8 bits (164), Expect = 1e-11
Identities = 64/244 (26%), Positives = 106/244 (43%), Gaps = 22/244 (9%)
Query: 55 FWGHKGAVWGATLNATK--AATAAADFTAKVW-DAVLGDELMTLAHKYIVKTVYFMQDSN 111
F GHK AV + + A+ + D T ++W V G+ + AH V++V+F D
Sbjct: 57 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQ 116
Query: 112 YLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQIL--SADDKTARLWD 169
+T DK ++++ ++ K +S H + + R S D +++ ++DDKT +LWD
Sbjct: 117 SFVTASDDKTVKVWATHRQKFL-FSLSQHINWV--RCAKFSPDGRLIVSASDDKTVKLWD 173
Query: 170 HATMTEVKSL-NFNMSVSSTKYIPEGEILVITYGLS-------IAFHSAVSLDPITSFEA 221
++ V S V+ + P G + G+ + H + + S
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAA-GMDNTVKVWDVRTHRLLQHYQLHS--- 229
Query: 222 PATINSASLHPEKEFLVAGGEDFKLYKY-FNHGEEFESYKGYFGPIHCVRFSRDGELYAS 280
A +N S HP +L+ D L G + G+ GP V FSR GE +AS
Sbjct: 230 -AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS 288
Query: 281 GSED 284
G D
Sbjct: 289 GGSD 292
Score = 37.0 bits (84), Expect = 0.026
Identities = 42/194 (21%), Positives = 71/194 (36%), Gaps = 41/194 (21%)
Query: 97 HKYIVKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQ 156
H+ V V F ++ L + D L ++ + KP++R +GH + S
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHM-KPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 157 ILSADDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPI 216
+ DKT R+W V + K G S F +
Sbjct: 77 ASGSRDKTVRIW----------------VPNVK------------GESTVFRAHT----- 103
Query: 217 TSFEAPATINSASLHPEKEFLVAGGEDFKLYKYFNHGEEFE-SYKGYFGPIHCVRFSRDG 275
AT+ S + + V +D + + H ++F S + + C +FS DG
Sbjct: 104 ------ATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 276 ELYASGSEDGTLRL 289
L S S+D T++L
Sbjct: 158 RLIVSASDDKTVKL 171
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 67.8 bits (164), Expect = 1e-11
Identities = 64/244 (26%), Positives = 106/244 (43%), Gaps = 22/244 (9%)
Query: 55 FWGHKGAVWGATLNATK--AATAAADFTAKVW-DAVLGDELMTLAHKYIVKTVYFMQDSN 111
F GHK AV + + A+ + D T ++W V G+ + AH V++V+F D
Sbjct: 57 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQ 116
Query: 112 YLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQIL--SADDKTARLWD 169
+T DK ++++ ++ K +S H + + R S D +++ ++DDKT +LWD
Sbjct: 117 SFVTASDDKTVKVWATHRQKFL-FSLSQHINWV--RCAKFSPDGRLIVSASDDKTVKLWD 173
Query: 170 HATMTEVKSL-NFNMSVSSTKYIPEGEILVITYGLS-------IAFHSAVSLDPITSFEA 221
++ V S V+ + P G + G+ + H + + S
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAA-GMDNTVKVWDVRTHRLLQHYQLHS--- 229
Query: 222 PATINSASLHPEKEFLVAGGEDFKLYKY-FNHGEEFESYKGYFGPIHCVRFSRDGELYAS 280
A +N S HP +L+ D L G + G+ GP V FSR GE +AS
Sbjct: 230 -AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS 288
Query: 281 GSED 284
G D
Sbjct: 289 GGSD 292
Score = 37.0 bits (84), Expect = 0.026
Identities = 42/194 (21%), Positives = 71/194 (36%), Gaps = 41/194 (21%)
Query: 97 HKYIVKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQ 156
H+ V V F ++ L + D L ++ + KP++R +GH + S
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHM-KPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 157 ILSADDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPI 216
+ DKT R+W V + K G S F +
Sbjct: 77 ASGSRDKTVRIW----------------VPNVK------------GESTVFRAHT----- 103
Query: 217 TSFEAPATINSASLHPEKEFLVAGGEDFKLYKYFNHGEEFE-SYKGYFGPIHCVRFSRDG 275
AT+ S + + V +D + + H ++F S + + C +FS DG
Sbjct: 104 ------ATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 276 ELYASGSEDGTLRL 289
L S S+D T++L
Sbjct: 158 RLIVSASDDKTVKL 171
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 63.5 bits (153), Expect = 3e-10
Identities = 70/290 (24%), Positives = 119/290 (41%), Gaps = 56/290 (19%)
Query: 55 FWGHKGAVWGATL--NATKAATAAADFTAKVWD-AVLGDELMTLAHKYIVKTVYFMQDSN 111
F GHK A+ L N + ATA+ D +W+ + HK +V +V F N
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 112 YLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILS--ADDKTARLWD 169
L + +D+ +R++ +K + + E HT+ + R + S D Q L+ ++DK+ ++W
Sbjct: 74 LLASASRDRTVRLWIPDK-RGKFSEFKAHTAPV--RSVDFSADGQFLATASEDKSIKVWS 130
Query: 170 HATMTEVKSLNFNMS-VSSTKYIPEGEILVI-------------------TYGLSIAFHS 209
+ SL + V K+ P+G ++V + S+ F +
Sbjct: 131 MYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN 190
Query: 210 AVSLDPITSFEAPAT-------------------------INSASLHPEKEFLVAGGEDF 244
V +P + A A +N S HP +L+ D
Sbjct: 191 FVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDG 250
Query: 245 KLYKYFN--HGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQT 292
L K + G + +G+ GP+ V FS+ GEL+ASG D + L +T
Sbjct: 251 TL-KILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRT 299
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 61.6 bits (148), Expect = 1e-09
Identities = 42/152 (27%), Positives = 72/152 (47%), Gaps = 4/152 (2%)
Query: 29 GYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKGAVWGATLNAT--KAATAAADFTAKVWDA 86
G L Y+DG + +G+ TF GHK A+ + + A+ + D VWD
Sbjct: 77 GLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDV 136
Query: 87 VLGDELMTL-AHKYIVKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIK 145
+ L L HK + F+++ N L+T G+D +++ +DL+ K + GH + +
Sbjct: 137 INESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCF-KTMVGHRTEVW 195
Query: 146 KRLLWCSEDKQILSADDKTARLWDHATMTEVK 177
+L E + I A D R+WD A + E++
Sbjct: 196 GLVLLSEEKRLITGASDSELRVWDIAYLQEIE 227
Score = 46.2 bits (108), Expect = 4e-05
Identities = 39/131 (29%), Positives = 62/131 (47%), Gaps = 14/131 (10%)
Query: 47 DTGDWIGTFWGHKGAVWGATLNATKA--ATAAADFTAKVWDAVLGDELMTL-AHKYIVKT 103
DT + + +GHK V ++ A AT +AD K+W GD +L AH V
Sbjct: 579 DTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMY 638
Query: 104 VYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWC-----SEDKQIL 158
+ F+ S+ T G+D ++ +D +K + + + GH I WC S D +
Sbjct: 639 LQFVPKSHLFFTAGKDHKIKQWDADKFE-HIQTLEGHHQEI-----WCLAVSPSGDYVVS 692
Query: 159 SADDKTARLWD 169
S+ DK+ RLW+
Sbjct: 693 SSHDKSLRLWE 703
Score = 41.2 bits (95), Expect = 0.001
Identities = 42/192 (21%), Positives = 88/192 (45%), Gaps = 21/192 (10%)
Query: 118 QDKLLRMYDLNKPKARPKE-------ISGHTSGIKKRLLWCSEDKQILSADDKTARLWDH 170
Q+ L+ +Y LN P+ I GH S ++ L + S++ +LSA + ++W+
Sbjct: 385 QNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRT-LSFSSDNIAVLSAAADSIKIWNR 443
Query: 171 ATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEA-PATINSAS 229
+T+ ++++ ++ S + ++++ T + + S + + + +A + S S
Sbjct: 444 STLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMS 503
Query: 230 LHPEKEFLVAGGE-------DFKLYKYFNHGEEFESYK-----GYFGPIHCVRFSRDGEL 277
L P++ V GG DF+L K N ++ S K + CV +S + +L
Sbjct: 504 LSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKL 563
Query: 278 YASGSEDGTLRL 289
A D T+++
Sbjct: 564 LAVSLLDCTVKI 575
Score = 33.5 bits (75), Expect = 0.29
Identities = 53/257 (20%), Positives = 98/257 (38%), Gaps = 33/257 (12%)
Query: 37 KDGKPMLRQGDTGDWIGTFWGHKGAVWGATLNATKA--ATAAADFTAKVWDAVLGDELMT 94
K GK L +G+ + T H GA+W +L+ + T AD + K WD L + +
Sbjct: 474 KTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENS 533
Query: 95 LAHKYIVKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSED 154
+ VK +Q +D L Y N+ K ++ ++ +
Sbjct: 534 TQKRLSVKQTRTLQ-------LDEDVLCVSYSPNQ-----KLLAVSLLDCTVKIFYVDTL 581
Query: 155 KQILSADDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIA-FHSAVSL 213
K LS L+ H ++ + ++ +T + V +GL H ++
Sbjct: 582 KFFLS-------LYGHKLPVICMDISHDGALIAT---GSADRNVKIWGLDFGDCHKSL-- 629
Query: 214 DPITSFEAPATINSASLHPEKEFLVAGGEDFKLYKY-FNHGEEFESYKGYFGPIHCVRFS 272
F ++ P+ G+D K+ ++ + E ++ +G+ I C+ S
Sbjct: 630 -----FAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVS 684
Query: 273 RDGELYASGSEDGTLRL 289
G+ S S D +LRL
Sbjct: 685 PSGDYVVSSSHDKSLRL 701
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 61.2 bits (147), Expect = 1e-09
Identities = 70/296 (23%), Positives = 126/296 (42%), Gaps = 12/296 (4%)
Query: 2 AMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKGA 61
A + L T GH + +AF+ YG + + D L +TG TF GH
Sbjct: 122 ASGEELNTLEGHRNVVYAIAFNN--PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAE 179
Query: 62 VWGATLN--ATKAATAAADFTAKVWDAVLGDELMTL-AHKYIVKTVYFMQDSNYLLTKGQ 118
+ + N +T AT + D TAK+WD G+E+ TL H + ++ F + ++T
Sbjct: 180 IVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSF 239
Query: 119 DKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKS 178
D + ++D + + + + GH + I + + DKT +LWD V +
Sbjct: 240 DHTVVVWDADTGR-KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVAT 298
Query: 179 L-NFNMSVSSTKYIPEGEILVITYGLSIA-FHSAVSLDPITSFEA-PATINSASLHPEKE 235
L + + + + G+++ A SA + I E I+ S +P+
Sbjct: 299 LTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358
Query: 236 FLVAGGEDFKLYKYFN--HGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRL 289
L+ G D K + ++ G+ + +G+ I F+ G + +GS+D T R+
Sbjct: 359 HLLTGSSD-KTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRI 413
Score = 50.8 bits (120), Expect = 2e-06
Identities = 67/254 (26%), Positives = 105/254 (41%), Gaps = 24/254 (9%)
Query: 74 TAAADFTAKVWDAVLGDELMTL-AHKYIVKTVYFMQD-SNYLLTKGQDKLLRMYDLNKPK 131
T + D T K+WD G+EL TL H+ +V + F + + T DK +++ + K
Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK 168
Query: 132 ARPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKSL-NFNMSVSSTKY 190
GHT+ I + D TA+LWD EV +L + + S +
Sbjct: 169 CY-HTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227
Query: 191 IPEGEILVITYGLSIAFHSAVSLDPITSFEAP------ATINSASLHPEKEFLVAGGED- 243
G+ +IT H+ V D T + A I+SAS + + ++ G D
Sbjct: 228 NTSGD-RIITGSFD---HTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDK 283
Query: 244 -FKLYKYFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGLWK 302
KL+ N G+ + G+ I F G+L A+ S DGT R+ K
Sbjct: 284 TCKLWDATN-GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR------K 336
Query: 303 CVLP-EEESGELAK 315
C+ E GE++K
Sbjct: 337 CIAKLEGHEGEISK 350
Score = 32.7 bits (73), Expect = 0.49
Identities = 38/152 (25%), Positives = 61/152 (40%), Gaps = 19/152 (12%)
Query: 157 ILSADDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPI 216
I + D+T +LWD A+ E+ +L + +V YG IA S +
Sbjct: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNN------PYGDKIATGSFDKTCKL 161
Query: 217 TSFEA----------PATINSASLHPEKEFLVAGGED--FKLYKYFNHGEEFESYKGYFG 264
S E A I S +P+ + G D KL+ N GEE + +G+
Sbjct: 162 WSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN-GEEVYTLRGHSA 220
Query: 265 PIHCVRFSRDGELYASGSEDGTLRLGQTVVGK 296
I + F+ G+ +GS D T+ + G+
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDADTGR 252
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 60.5 bits (145), Expect = 2e-09
Identities = 59/251 (23%), Positives = 100/251 (39%), Gaps = 46/251 (18%)
Query: 48 TGDWIGTFWGHKGAVWGATLNATK--AATAAADFTAKVWDAVLGDELMTL-AHKYIVKTV 104
T + +GH G V+GA+ + + +++ D T ++W L+ H Y V
Sbjct: 532 TASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDT 591
Query: 105 YFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEI-SGHTSGIKKRLLWCSEDKQILSADDK 163
F Y ++ G D++ R++ + +P I +GH + + + + + D+
Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDH--YQPLRIFAGHLADVNCTRFHPNSNYVATGSADR 649
Query: 164 TARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPA 223
T RLWD + G + I T + P
Sbjct: 650 TVRLWD---------------------VLNGNCVRI----------------FTGHKGP- 671
Query: 224 TINSASLHPEKEFLVAGGEDFKLYKY-FNHGEEFESYKGYFGPIHCVRFSRDGELYASGS 282
I+S + P FL G D ++ + HG KG+ + +RFSRDGE+ ASGS
Sbjct: 672 -IHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGS 730
Query: 283 EDGTLRLGQTV 293
D T+RL +
Sbjct: 731 MDNTVRLWDAI 741
Score = 38.5 bits (88), Expect = 0.009
Identities = 47/212 (22%), Positives = 81/212 (38%), Gaps = 27/212 (12%)
Query: 94 TLAHKYIVKTVYFMQDSNYLLTKG-QDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCS 152
T + Y T + D + L+ G D +R++ + K R + + S I K
Sbjct: 465 TFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKE----- 519
Query: 153 EDKQILSADDKTARLWDHATMTEVKSL-NFNMSVSSTKYIPEGEILVITYGLSIAFHSAV 211
+DD R+ D T +E+K L + V + P+ L LS + V
Sbjct: 520 -------SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYL-----LSSSEDGTV 567
Query: 212 SLDPITSFEAPA-------TINSASLHPEKEFLVAGGEDFKLYKYF-NHGEEFESYKGYF 263
L + +F + P + V+GG D + +H + + G+
Sbjct: 568 RLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHL 627
Query: 264 GPIHCVRFSRDGELYASGSEDGTLRLGQTVVG 295
++C RF + A+GS D T+RL + G
Sbjct: 628 ADVNCTRFHPNSNYVATGSADRTVRLWDVLNG 659
Score = 33.5 bits (75), Expect = 0.29
Identities = 23/80 (28%), Positives = 36/80 (45%), Gaps = 5/80 (6%)
Query: 10 YFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKGAVWGA--TL 67
+ GH P+ L FS G FL + DG+ +L G +G GH V +
Sbjct: 665 FTGHKGPIHSLTFS---PNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSR 721
Query: 68 NATKAATAAADFTAKVWDAV 87
+ A+ + D T ++WDA+
Sbjct: 722 DGEILASGSMDNTVRLWDAI 741
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 60.5 bits (145), Expect = 2e-09
Identities = 63/276 (22%), Positives = 115/276 (41%), Gaps = 12/276 (4%)
Query: 23 SGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKGAVWGATLNATKA--ATAAADFT 80
S + G L + +DG + +G + GH G V + A+A+ D T
Sbjct: 27 SAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCT 86
Query: 81 AKVWDAVLGDELMTL-AHKYIVKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISG 139
++WD L L H+ V+TV F DS L + G DK + ++D+ + + + G
Sbjct: 87 VRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQML-RLLVG 145
Query: 140 HTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKSLN----FNMSVSSTKYIPEGE 195
H I+ + + + D T +WD +T S + ++S Y G
Sbjct: 146 HRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGL 205
Query: 196 ILVITYGLSIAFHSAVSLDPITSFEAPAT-INSASLHPEKEFLVAGGEDFKLYKYF--NH 252
+ ++ +I + + + T + S + P++ +L + G ++ K + N
Sbjct: 206 LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYS-RMVKVWDCNT 264
Query: 253 GEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLR 288
G+ E+ KG H F+ DG++ SG+ D T R
Sbjct: 265 GKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 45.4 bits (106), Expect = 7e-05
Identities = 25/66 (37%), Positives = 38/66 (57%), Gaps = 1/66 (1%)
Query: 225 INSASLHPEKEFLVAGGEDFKLYKYFNH-GEEFESYKGYFGPIHCVRFSRDGELYASGSE 283
+NS++ P+ + L+ G ED +Y + G+ G+ GP+ RFS DG L+AS S
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASC 83
Query: 284 DGTLRL 289
D T+RL
Sbjct: 84 DCTVRL 89
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 59.7 bits (143), Expect = 4e-09
Identities = 56/224 (25%), Positives = 99/224 (44%), Gaps = 32/224 (14%)
Query: 73 ATAAADFTAKVWDAVLGDELMTL-AHKYIVKTVYFMQDSNYLL--TKGQDKLLRMYDLNK 129
AT + D K+W+++ G+ + T H V +F S++LL T D L+++DLN+
Sbjct: 673 ATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 732
Query: 130 PKARPKEISGHTSGIKKRLLWCSEDKQILSAD-DKTARLWDHATMTEVKSLNFNMSVSST 188
+ R + GHT+ + + +DK + S D T +LWD + E KS+N +
Sbjct: 733 KECR-NTMFGHTNSVN-HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 790
Query: 189 KYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLVAGGEDFKLYK 248
+ P+ ++ VI S + A +VA L+
Sbjct: 791 ED-PQEDMEVIVKCCSWSADGA------------------------RIMVAAKNKIFLWN 825
Query: 249 YFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQT 292
+ + + +G+ +H V FS DG + + S+D T+RL +T
Sbjct: 826 TDSRSKVADC-RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 868
Score = 40.8 bits (94), Expect = 0.002
Identities = 50/258 (19%), Positives = 105/258 (40%), Gaps = 31/258 (12%)
Query: 54 TFWGHKGAVWGATLNATKA--ATAAADFTAKVWDAVLGDELMTLAHKY------------ 99
T +GH +V + A+ +AD T K+WDA +E ++ K
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797
Query: 100 --IVKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQI 157
IVK + D ++ ++K+ ++ K + GH S + + +
Sbjct: 798 EVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVA--DCRGHLSWVHGVMFSPDGSSFL 855
Query: 158 LSADDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYG----LSIAFHSAVSL 213
S+DD+T RLW+ + + ++ V E E++V+ L + +
Sbjct: 856 TSSDDQTIRLWETKKVCKNSAVMLKQEVDVV--FQENEVMVLAVDHIRRLQLINGRTGQI 913
Query: 214 DPITSFEAPATINSASLHPEKEFLVAGGED--FKLYKYFNHGEEFESYKGYFGPIHCVRF 271
D +T A ++ L P +++ G E+ ++ + N+ F+S + + ++F
Sbjct: 914 DYLTE----AQVSCCCLSPHLQYIAFGDENGAIEILELVNN-RIFQSRFQHKKTVWHIQF 968
Query: 272 SRDGELYASGSEDGTLRL 289
+ D + S S+D +++
Sbjct: 969 TADEKTLISSSDDAEIQV 986
Score = 32.7 bits (73), Expect = 0.49
Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Query: 48 TGDWIGTFWGHKGAVWGATLN--ATKAATAAADFTAKVWDAVLGDELMTL-AHKYIVKTV 104
TG+ F H+G V ++ ATK ++ +AD TAK+W L L L H V+
Sbjct: 1031 TGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCS 1090
Query: 105 YFMQDSNYLLTKGQDKLLRMYDLN 128
F DS L T + +R+++++
Sbjct: 1091 AFSVDSTLLATGDDNGEIRIWNVS 1114
Score = 28.5 bits (62), Expect = 9.3
Identities = 11/30 (36%), Positives = 19/30 (63%)
Query: 260 KGYFGPIHCVRFSRDGELYASGSEDGTLRL 289
+G+ G + C FS D L A+G ++G +R+
Sbjct: 1081 RGHNGCVRCSAFSVDSTLLATGDDNGEIRI 1110
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 59.7 bits (143), Expect = 4e-09
Identities = 56/224 (25%), Positives = 99/224 (44%), Gaps = 32/224 (14%)
Query: 73 ATAAADFTAKVWDAVLGDELMTL-AHKYIVKTVYFMQDSNYLL--TKGQDKLLRMYDLNK 129
AT + D K+W+++ G+ + T H V +F S++LL T D L+++DLN+
Sbjct: 662 ATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 721
Query: 130 PKARPKEISGHTSGIKKRLLWCSEDKQILSAD-DKTARLWDHATMTEVKSLNFNMSVSST 188
+ R + GHT+ + + +DK + S D T +LWD + E KS+N +
Sbjct: 722 KECR-NTMFGHTNSVN-HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 779
Query: 189 KYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLVAGGEDFKLYK 248
+ P+ ++ VI S + A +VA L+
Sbjct: 780 ED-PQEDMEVIVKCCSWSADGA------------------------RIMVAAKNKIFLWN 814
Query: 249 YFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQT 292
+ + + +G+ +H V FS DG + + S+D T+RL +T
Sbjct: 815 TDSRSKVADC-RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 857
Score = 40.8 bits (94), Expect = 0.002
Identities = 50/258 (19%), Positives = 105/258 (40%), Gaps = 31/258 (12%)
Query: 54 TFWGHKGAVWGATLNATKA--ATAAADFTAKVWDAVLGDELMTLAHKY------------ 99
T +GH +V + A+ +AD T K+WDA +E ++ K
Sbjct: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
Query: 100 --IVKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQI 157
IVK + D ++ ++K+ ++ K + GH S + + +
Sbjct: 787 EVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVA--DCRGHLSWVHGVMFSPDGSSFL 844
Query: 158 LSADDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYG----LSIAFHSAVSL 213
S+DD+T RLW+ + + ++ V E E++V+ L + +
Sbjct: 845 TSSDDQTIRLWETKKVCKNSAVMLKQEVDVV--FQENEVMVLAVDHIRRLQLINGRTGQI 902
Query: 214 DPITSFEAPATINSASLHPEKEFLVAGGED--FKLYKYFNHGEEFESYKGYFGPIHCVRF 271
D +T A ++ L P +++ G E+ ++ + N+ F+S + + ++F
Sbjct: 903 DYLTE----AQVSCCCLSPHLQYIAFGDENGAIEILELVNN-RIFQSRFQHKKTVWHIQF 957
Query: 272 SRDGELYASGSEDGTLRL 289
+ D + S S+D +++
Sbjct: 958 TADEKTLISSSDDAEIQV 975
Score = 32.7 bits (73), Expect = 0.49
Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Query: 48 TGDWIGTFWGHKGAVWGATLN--ATKAATAAADFTAKVWDAVLGDELMTL-AHKYIVKTV 104
TG+ F H+G V ++ ATK ++ +AD TAK+W L L L H V+
Sbjct: 1020 TGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCS 1079
Query: 105 YFMQDSNYLLTKGQDKLLRMYDLN 128
F DS L T + +R+++++
Sbjct: 1080 AFSVDSTLLATGDDNGEIRIWNVS 1103
Score = 28.5 bits (62), Expect = 9.3
Identities = 11/30 (36%), Positives = 19/30 (63%)
Query: 260 KGYFGPIHCVRFSRDGELYASGSEDGTLRL 289
+G+ G + C FS D L A+G ++G +R+
Sbjct: 1070 RGHNGCVRCSAFSVDSTLLATGDDNGEIRI 1099
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 57.8 bits (138), Expect = 1e-08
Identities = 64/259 (24%), Positives = 109/259 (42%), Gaps = 30/259 (11%)
Query: 9 TYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKGAV---WGA 65
T GH+ +++L ++ T G L SA D + +TG+ + GH V + A
Sbjct: 104 TLKGHSGAVMELHYN---TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPA 160
Query: 66 TLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQDKLLRMY 125
T + D T K+WD + T + Y V V F S+ +++ G D ++++
Sbjct: 161 RRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
Query: 126 DLNKPKARPKEISGHTSGIKKRLLWCSEDKQILS-ADDKTARLWDHATMTEVKSL----- 179
DL + K + GH + L SE +LS A D T R+WD +
Sbjct: 221 DLRQNKLT-YTMRGHADSVTGLSL-SSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQ 278
Query: 180 ----NFNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITS----FEAPA---TINSA 228
NF ++ + P+G I G + F V + TS ++ P +IN
Sbjct: 279 GNVHNFEKNLLRCSWSPDGS--KIAAGSADRF---VYVWDTTSRRILYKLPGHAGSINEV 333
Query: 229 SLHPEKEFLVAGGEDFKLY 247
+ HP++ +++ D +LY
Sbjct: 334 AFHPDEPIIISASSDKRLY 352
Score = 30.4 bits (67), Expect = 2.5
Identities = 16/68 (23%), Positives = 32/68 (47%), Gaps = 2/68 (2%)
Query: 231 HPEKEFLVAGGED--FKLYKYFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLR 288
HP L + G D L+ + + + + KG+ G + + ++ DG + S S D T+
Sbjct: 75 HPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVA 134
Query: 289 LGQTVVGK 296
+ + G+
Sbjct: 135 VWDSETGE 142
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 57.0 bits (136), Expect = 2e-08
Identities = 47/164 (28%), Positives = 75/164 (45%), Gaps = 9/164 (5%)
Query: 10 YFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKGAVWGATL-- 67
Y GH +P+ DL I+ Y + S D L D + + GH V
Sbjct: 380 YQGHAYPVWDL---DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHP 436
Query: 68 NATKAATAAADFTAKVWDAVLGDEL-MTLAHKYIVKTVYFMQDSNYLLTKGQDKLLRMYD 126
N+ AT + D T ++W A G+ + + H+ V ++ F + YL + G+D+ L+++D
Sbjct: 437 NSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD 496
Query: 127 LNKPKARPKEISGHTSGIKKRLLWCSEDKQILSAD-DKTARLWD 169
L KE+ GHT I L + + I SA D + R+WD
Sbjct: 497 LASGTLY-KELRGHTDNITS-LTFSPDSGLIASASMDNSVRVWD 538
Score = 42.0 bits (97), Expect = 8e-04
Identities = 40/162 (24%), Positives = 59/162 (36%), Gaps = 26/162 (16%)
Query: 148 LLWCSEDKQILSADDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAF 207
LL CSED I R WD + T N + P ++ + Y L A
Sbjct: 357 LLSCSEDMSI--------RYWDLGSFT-------NTVLYQGHAYPVWDLDISPYSLYFAS 401
Query: 208 HSAVSLDPITSFEAP----------ATINSASLHPEKEFLVAGGEDFKLYKYF-NHGEEF 256
S + SF+ A ++ HP +L G D + + G
Sbjct: 402 GSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSV 461
Query: 257 ESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTY 298
+ G+ GP+ + FS +G+ AS ED L+L G Y
Sbjct: 462 RLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLY 503
Score = 37.0 bits (84), Expect = 0.026
Identities = 43/206 (20%), Positives = 81/206 (39%), Gaps = 15/206 (7%)
Query: 100 IVKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILS 159
++ T DS L + ++++ L K + + H + + L C IL
Sbjct: 270 LLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEP---HQVDVSRIHLACD----ILE 322
Query: 160 ADDKTARLWDHATMTEVKSLNFNMS-VSSTKYIPEGE-ILVITYGLSIAFHSAVSLDPIT 217
+D D TE+K L + V ST+++ + +L + +SI + S
Sbjct: 323 EEDDE----DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTV 378
Query: 218 SFEAPA-TINSASLHPEKEFLVAGGEDFKLYKY-FNHGEEFESYKGYFGPIHCVRFSRDG 275
++ A + + P + +G D + F+ Y G+ + CV+F +
Sbjct: 379 LYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNS 438
Query: 276 ELYASGSEDGTLRLGQTVVGKTYGLW 301
A+GS D T+RL G + L+
Sbjct: 439 NYLATGSTDKTVRLWSAQQGNSVRLF 464
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 56.6 bits (135), Expect = 3e-08
Identities = 56/245 (22%), Positives = 110/245 (44%), Gaps = 20/245 (8%)
Query: 52 IGTFWGHKGAVWGATLNATKA--ATAAADFTAKVWDAVLGDELMTL-AHKYIVKTVYFMQ 108
I F H G V G + + + D+ KVW+ L L TL H ++T +F
Sbjct: 44 IDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHH 103
Query: 109 DSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLW 168
+ ++L+ D+ +R+++ + ++GH + +ED + ++ D+T R+W
Sbjct: 104 EYPWILSASDDQTIRVWNWQS-RTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVW 162
Query: 169 DHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSA 228
D + + + N+S + + G V +G + AV + + +N A
Sbjct: 163 DISGLRKK-----NLSPGAVESDVRGITGVDLFGTT----DAVVKHVLEGHDRG--VNWA 211
Query: 229 SLHPEKEFLVAGGEDFKLYKYFNHGE----EFESYKGYFGPIHCVRFSRDGELYASGSED 284
+ HP +V+G +D ++ K + E E ++ +G++ + C F EL S SED
Sbjct: 212 AFHPTMPLIVSGADDRQV-KIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSED 270
Query: 285 GTLRL 289
++R+
Sbjct: 271 KSIRV 275
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 56.6 bits (135), Expect = 3e-08
Identities = 56/245 (22%), Positives = 110/245 (44%), Gaps = 20/245 (8%)
Query: 52 IGTFWGHKGAVWGATLNATKA--ATAAADFTAKVWDAVLGDELMTL-AHKYIVKTVYFMQ 108
I F H G V G + + + D+ KVW+ L L TL H ++T +F
Sbjct: 44 IDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHH 103
Query: 109 DSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLW 168
+ ++L+ D+ +R+++ + ++GH + +ED + ++ D+T R+W
Sbjct: 104 EYPWILSASDDQTIRVWNWQS-RTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVW 162
Query: 169 DHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSA 228
D + + + N+S + + G V +G + AV + + +N A
Sbjct: 163 DISGLRKK-----NLSPGAVESDVRGITGVDLFGTT----DAVVKHVLEGHDRG--VNWA 211
Query: 229 SLHPEKEFLVAGGEDFKLYKYFNHGE----EFESYKGYFGPIHCVRFSRDGELYASGSED 284
+ HP +V+G +D ++ K + E E ++ +G++ + C F EL S SED
Sbjct: 212 AFHPTMPLIVSGADDRQV-KIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSED 270
Query: 285 GTLRL 289
++R+
Sbjct: 271 KSIRV 275
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 55.5 bits (132), Expect = 7e-08
Identities = 54/206 (26%), Positives = 87/206 (42%), Gaps = 44/206 (21%)
Query: 94 TLA-HKYIVKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCS 152
TLA H V +V F + +L + DKL++++ K K ISGH GI + W S
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISD-VAWSS 97
Query: 153 EDKQILSA-DDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFHSAV 211
+ ++SA DDKT ++WD VSS K + ++ HS
Sbjct: 98 DSNLLVSASDDKTLKIWD---------------VSSGKCLK-----------TLKGHSNY 131
Query: 212 SLDPITSFEAPATINSASLHPEKEFLVAGGEDFKLYKY-FNHGEEFESYKGYFGPIHCVR 270
+ + +P+ +V+G D + + G+ ++ + P+ V
Sbjct: 132 -------------VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH 178
Query: 271 FSRDGELYASGSEDGTLRLGQTVVGK 296
F+RDG L S S DG R+ T G+
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQ 204
Score = 50.4 bits (119), Expect = 2e-06
Identities = 52/200 (26%), Positives = 84/200 (42%), Gaps = 18/200 (9%)
Query: 9 TYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKGAVWGATLN 68
T GH + D+A+S + L SA D + +G + T GH V+ N
Sbjct: 82 TISGHKLGISDVAWSSDSN---LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN 138
Query: 69 ATKAATAAADF--TAKVWDAVLGDELMTL-AHKYIVKTVYFMQDSNYLLTKGQDKLLRMY 125
+ F + ++WD G L TL AH V V+F +D + +++ D L R++
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 126 DLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSAD-DKTARLWDHA------TMTEVKS 178
D + I + + + K IL+A D T +LWD++ T T K+
Sbjct: 199 DTASGQCLKTLIDDDNPPV-SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257
Query: 179 LNF----NMSVSSTKYIPEG 194
+ N SV+ K+I G
Sbjct: 258 EKYCIFANFSVTGGKWIVSG 277
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 55.5 bits (132), Expect = 7e-08
Identities = 54/206 (26%), Positives = 87/206 (42%), Gaps = 44/206 (21%)
Query: 94 TLA-HKYIVKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCS 152
TLA H V +V F + +L + DKL++++ K K ISGH GI + W S
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISD-VAWSS 97
Query: 153 EDKQILSA-DDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFHSAV 211
+ ++SA DDKT ++WD VSS K + ++ HS
Sbjct: 98 DSNLLVSASDDKTLKIWD---------------VSSGKCLK-----------TLKGHSNY 131
Query: 212 SLDPITSFEAPATINSASLHPEKEFLVAGGEDFKLYKY-FNHGEEFESYKGYFGPIHCVR 270
+ + +P+ +V+G D + + G+ ++ + P+ V
Sbjct: 132 -------------VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH 178
Query: 271 FSRDGELYASGSEDGTLRLGQTVVGK 296
F+RDG L S S DG R+ T G+
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQ 204
Score = 50.4 bits (119), Expect = 2e-06
Identities = 52/200 (26%), Positives = 84/200 (42%), Gaps = 18/200 (9%)
Query: 9 TYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKGAVWGATLN 68
T GH + D+A+S + L SA D + +G + T GH V+ N
Sbjct: 82 TISGHKLGISDVAWSSDSN---LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN 138
Query: 69 ATKAATAAADF--TAKVWDAVLGDELMTL-AHKYIVKTVYFMQDSNYLLTKGQDKLLRMY 125
+ F + ++WD G L TL AH V V+F +D + +++ D L R++
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 126 DLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSAD-DKTARLWDHA------TMTEVKS 178
D + I + + + K IL+A D T +LWD++ T T K+
Sbjct: 199 DTASGQCLKTLIDDDNPPV-SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257
Query: 179 LNF----NMSVSSTKYIPEG 194
+ N SV+ K+I G
Sbjct: 258 EKYCIFANFSVTGGKWIVSG 277
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 55.5 bits (132), Expect = 7e-08
Identities = 52/205 (25%), Positives = 84/205 (40%), Gaps = 44/205 (21%)
Query: 95 LAHKYIVKTVYFMQDSNYLL-TKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSE 153
+AH V ++ + S LL T G D + ++ +NKP ++GHTS ++ L E
Sbjct: 17 VAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCI-MSLTGHTSPVESVRLNTPE 75
Query: 154 DKQILSADDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFHSAVSL 213
+ + + + R+WD + +IL G
Sbjct: 76 ELIVAGSQSGSIRVWD---------------------LEAAKILRTLMGHK--------- 105
Query: 214 DPITSFEAPATINSASLHPEKEFLVAGGED--FKLYKYFNHGEEFESYKGYFGPIHCVRF 271
A I S HP EF+ +G +D KL+ G F Y+G+ + C+RF
Sbjct: 106 ---------ANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFR-YRGHSQAVRCLRF 155
Query: 272 SRDGELYASGSEDGTLRLGQTVVGK 296
S DG+ AS ++D T++L GK
Sbjct: 156 SPDGKWLASAADDHTVKLWDLTAGK 180
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 54.7 bits (130), Expect = 1e-07
Identities = 52/207 (25%), Positives = 86/207 (41%), Gaps = 9/207 (4%)
Query: 101 VKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSA 160
V+ V F D NY LT G DK L++++ + + SGH +
Sbjct: 28 VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLL-RTYSGHGYEVLDAAGSFDNSSLCSGG 86
Query: 161 DDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFHS----AVSLDPI 216
DK LWD A+ V+ + +T E ++++ + + + +P+
Sbjct: 87 GDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPV 146
Query: 217 TSFEAPATINSASLHPEKEFLVAGGEDFKLYKY-FNHGEEFESYKGYFGPIHCVRFSRDG 275
+ + A +S+ ++AG D ++ +Y G+ F Y G PI C FSRDG
Sbjct: 147 QTLDE-ARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDG 203
Query: 276 ELYASGSEDGTLRLGQTVVGKTYGLWK 302
+ S D TLRL G+ G +K
Sbjct: 204 QCTLVSSLDSTLRLLDKDTGELLGEYK 230
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 54.7 bits (130), Expect = 1e-07
Identities = 52/207 (25%), Positives = 86/207 (41%), Gaps = 9/207 (4%)
Query: 101 VKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSA 160
V+ V F D NY LT G DK L++++ + + SGH +
Sbjct: 28 VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLL-RTYSGHGYEVLDAAGSFDNSSLCSGG 86
Query: 161 DDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFHS----AVSLDPI 216
DK LWD A+ V+ + +T E ++++ + + + +P+
Sbjct: 87 GDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPV 146
Query: 217 TSFEAPATINSASLHPEKEFLVAGGEDFKLYKY-FNHGEEFESYKGYFGPIHCVRFSRDG 275
+ + A +S+ ++AG D ++ +Y G+ F Y G PI C FSRDG
Sbjct: 147 QTLDE-ARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDG 203
Query: 276 ELYASGSEDGTLRLGQTVVGKTYGLWK 302
+ S D TLRL G+ G +K
Sbjct: 204 QCTLVSSLDSTLRLLDKDTGELLGEYK 230
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 52.0 bits (123), Expect = 8e-07
Identities = 53/200 (26%), Positives = 92/200 (46%), Gaps = 29/200 (14%)
Query: 5 QTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKGAVWG 64
+ + T GH + +A I G + SA +D + + TG + TF GH+ V
Sbjct: 183 ECIRTMHGHDHNVSSVA---IMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRM 239
Query: 65 ATLN--ATKAATAAADFTAKVWDAVLGDELMTLA-HKYIVKTVYFMQDSNY--------- 112
N T A+ + D T +VW + L H+++V+ + + +S+Y
Sbjct: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299
Query: 113 -----------LLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILS-A 160
LL+ +DK ++M+D++ + GH + ++ +L+ S K ILS A
Sbjct: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCL-MTLVGHDNWVRG-VLFHSGGKFILSCA 357
Query: 161 DDKTARLWDHATMTEVKSLN 180
DDKT R+WD+ +K+LN
Sbjct: 358 DDKTLRVWDYKNKRCMKTLN 377
Score = 42.0 bits (97), Expect = 8e-04
Identities = 35/152 (23%), Positives = 65/152 (42%), Gaps = 10/152 (6%)
Query: 36 YKDGKPMLRQGDTGDWIG------TFWGHKGAVWGATLNATKAA--TAAADFTAKVWDAV 87
+ G P+ ++ D +WI GH+ V + + +A+ D T KVWD
Sbjct: 79 FTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYE 138
Query: 88 LGDELMTL-AHKYIVKTVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKK 146
GD TL H V+ + F L + D ++++D + + + GH +
Sbjct: 139 TGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFEC-IRTMHGHDHNVSS 197
Query: 147 RLLWCSEDKQILSADDKTARLWDHATMTEVKS 178
+ + D + ++ DKT ++W+ T VK+
Sbjct: 198 VAIMPNGDHIVSASRDKTIKMWEVQTGYCVKT 229
Score = 40.8 bits (94), Expect = 0.002
Identities = 40/170 (23%), Positives = 78/170 (45%), Gaps = 19/170 (11%)
Query: 133 RPKE---ISGHTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKSLNFNM-SVSST 188
RP E +SGH S + + + + +++D T ++WD+ T ++L + SV
Sbjct: 97 RPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDI 156
Query: 189 KYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPAT-------INSASLHPEKEFLVAGG 241
+ G++L S + + L FE T ++S ++ P + +V+
Sbjct: 157 SFDHSGKLLA-----SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSAS 211
Query: 242 ED--FKLYKYFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRL 289
D K+++ G +++ G+ + VR ++DG L AS S D T+R+
Sbjct: 212 RDKTIKMWE-VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRV 260
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 50.4 bits (119), Expect = 2e-06
Identities = 33/127 (25%), Positives = 66/127 (51%), Gaps = 7/127 (5%)
Query: 57 GHKGAVWGATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTK 116
GH G+V + T ++D T +VWD G+ L TL H + ++ ++ ++T
Sbjct: 305 GHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIH-HCEAVLHLRFNNGMMVTC 363
Query: 117 GQDKLLRMYDLNKPK--ARPKEISGHTSGIKKRLLWCSEDKQILSAD-DKTARLWDHATM 173
+D+ + ++D+ P + + GH + + + +DK I+SA D+T ++W+ +T
Sbjct: 364 SKDRSIAVWDMASPTDITLRRVLVGHRAAVN---VVDFDDKYIVSASGDRTIKVWNTSTC 420
Query: 174 TEVKSLN 180
V++LN
Sbjct: 421 EFVRTLN 427
Score = 39.7 bits (91), Expect = 0.004
Identities = 30/127 (23%), Positives = 57/127 (44%), Gaps = 9/127 (7%)
Query: 47 DTGDWIGTFWGHKGAVWGATLNATKAATAAADFTAKVWDAVLGDEL----MTLAHKYIVK 102
+TG+ + T H AV N T + D + VWD ++ + + H+ V
Sbjct: 335 NTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVN 394
Query: 103 TVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSADD 162
V F D Y+++ D+ +++++ + + + ++GH GI L + + + D
Sbjct: 395 VVDF--DDKYIVSASGDRTIKVWNTSTCEF-VRTLNGHKRGI--ACLQYRDRLVVSGSSD 449
Query: 163 KTARLWD 169
T RLWD
Sbjct: 450 NTIRLWD 456
Score = 33.9 bits (76), Expect = 0.22
Identities = 35/147 (23%), Positives = 66/147 (44%), Gaps = 11/147 (7%)
Query: 31 FLTSAYKDGKPMLRQGDTGDWIGTFWGHKGAVWGATLNATKAATAAADFTAKVWDAVLGD 90
++ SA D + T +++ T GHK + + ++D T ++WD G
Sbjct: 402 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGA 461
Query: 91 ELMTL-AHKYIVKTVYFMQDSNYLLTKGQDKLLRMYDL---NKPKARPKEISGHT----S 142
L L H+ +V+ + F D+ +++ D ++++DL P+A + T S
Sbjct: 462 CLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHS 519
Query: 143 GIKKRLLWCSEDKQILSADDKTARLWD 169
G RL + E + + S+ D T +WD
Sbjct: 520 GRVFRLQF-DEFQIVSSSHDDTILIWD 545
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 50.4 bits (119), Expect = 2e-06
Identities = 33/127 (25%), Positives = 66/127 (51%), Gaps = 7/127 (5%)
Query: 57 GHKGAVWGATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTK 116
GH G+V + T ++D T +VWD G+ L TL H + ++ ++ ++T
Sbjct: 341 GHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIH-HCEAVLHLRFNNGMMVTC 399
Query: 117 GQDKLLRMYDLNKPK--ARPKEISGHTSGIKKRLLWCSEDKQILSAD-DKTARLWDHATM 173
+D+ + ++D+ P + + GH + + + +DK I+SA D+T ++W+ +T
Sbjct: 400 SKDRSIAVWDMASPTDITLRRVLVGHRAAVN---VVDFDDKYIVSASGDRTIKVWNTSTC 456
Query: 174 TEVKSLN 180
V++LN
Sbjct: 457 EFVRTLN 463
Score = 39.7 bits (91), Expect = 0.004
Identities = 30/127 (23%), Positives = 57/127 (44%), Gaps = 9/127 (7%)
Query: 47 DTGDWIGTFWGHKGAVWGATLNATKAATAAADFTAKVWDAVLGDEL----MTLAHKYIVK 102
+TG+ + T H AV N T + D + VWD ++ + + H+ V
Sbjct: 371 NTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVN 430
Query: 103 TVYFMQDSNYLLTKGQDKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSADD 162
V F D Y+++ D+ +++++ + + + ++GH GI L + + + D
Sbjct: 431 VVDF--DDKYIVSASGDRTIKVWNTSTCEF-VRTLNGHKRGI--ACLQYRDRLVVSGSSD 485
Query: 163 KTARLWD 169
T RLWD
Sbjct: 486 NTIRLWD 492
Score = 33.9 bits (76), Expect = 0.22
Identities = 35/147 (23%), Positives = 66/147 (44%), Gaps = 11/147 (7%)
Query: 31 FLTSAYKDGKPMLRQGDTGDWIGTFWGHKGAVWGATLNATKAATAAADFTAKVWDAVLGD 90
++ SA D + T +++ T GHK + + ++D T ++WD G
Sbjct: 438 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGA 497
Query: 91 ELMTL-AHKYIVKTVYFMQDSNYLLTKGQDKLLRMYDL---NKPKARPKEISGHT----S 142
L L H+ +V+ + F D+ +++ D ++++DL P+A + T S
Sbjct: 498 CLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHS 555
Query: 143 GIKKRLLWCSEDKQILSADDKTARLWD 169
G RL + E + + S+ D T +WD
Sbjct: 556 GRVFRLQF-DEFQIVSSSHDDTILIWD 581
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 49.7 bits (117), Expect = 4e-06
Identities = 49/214 (22%), Positives = 91/214 (42%), Gaps = 23/214 (10%)
Query: 111 NYLLTKGQDKLLRMYDLNKPKARP--KEISGHTSGIKKRLLWCSEDKQILSADDKTARLW 168
N L T G+D ++R++ +N+ K P + HT + +L C+ I ++ D T ++W
Sbjct: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102
Query: 169 DHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLS--IAFHSAVSLDPITSFEAPATIN 226
+ + +L + + + LV + GL I +L +T+ T +
Sbjct: 103 NAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTS 162
Query: 227 SASLHPEKEF---------LVAGGEDFKLYKYFNHGE--EFESYKGYFGPIHCVRFSRDG 275
S S + + + ++ G K+ + ++ + KG+ + + +RDG
Sbjct: 163 SLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDG 222
Query: 276 ELYASGSEDGTLR---LGQTVVGKTY-----GLW 301
SGS DGT+R LGQ TY G+W
Sbjct: 223 TQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVW 256
Score = 41.2 bits (95), Expect = 0.001
Identities = 30/121 (24%), Positives = 54/121 (44%), Gaps = 9/121 (7%)
Query: 68 NATKAATAAADFTAKVWDAVLGDELMTL-AHKYIVKTVYFMQDSNYLLTKGQDKLLRMYD 126
N +A++D T KVW+A G + TL HK VK + + +D + + G D+ + ++D
Sbjct: 86 NGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
Query: 127 LNKPKA--------RPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKS 178
+N A +SG+ I + + + +K R+WD T ++
Sbjct: 146 VNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMK 205
Query: 179 L 179
L
Sbjct: 206 L 206
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,391,334
Number of Sequences: 37866
Number of extensions: 603188
Number of successful extensions: 2423
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 85
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 1838
Number of HSP's gapped (non-prelim): 537
length of query: 348
length of database: 18,247,518
effective HSP length: 103
effective length of query: 245
effective length of database: 14,347,320
effective search space: 3515093400
effective search space used: 3515093400
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.