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Search of human proteins with 10092639
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]
(1036 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens] 2298 0.0
gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens] 224 3e-58
gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens] 209 1e-53
gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens] 148 3e-35
gi|108773804 Fraser syndrome 1 [Homo sapiens] 145 2e-34
gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens] 140 5e-33
gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens] 135 2e-31
gi|37693519 BMP-binding endothelial regulator precursor protein ... 135 2e-31
gi|223029476 NEL-like protein 2 isoform d [Homo sapiens] 115 2e-25
gi|223029474 NEL-like protein 2 isoform c [Homo sapiens] 115 2e-25
gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens] 115 2e-25
gi|223029470 NEL-like protein 2 isoform a [Homo sapiens] 115 2e-25
gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens] 115 2e-25
gi|221316561 chordin-like 1 isoform 1 precursor [Homo sapiens] 97 1e-19
gi|221316563 chordin-like 1 isoform 2 precursor [Homo sapiens] 95 4e-19
gi|34147715 chordin-like 1 isoform 3 precursor [Homo sapiens] 94 5e-19
gi|40353769 chordin-like 2 [Homo sapiens] 93 1e-18
gi|30089980 chordin [Homo sapiens] 85 4e-16
gi|116284392 mucin 2 precursor [Homo sapiens] 82 2e-15
gi|239749951 PREDICTED: similar to mucin 2 [Homo sapiens] 82 2e-15
gi|89191868 von Willebrand factor preproprotein [Homo sapiens] 82 3e-15
gi|148833508 notch1 preproprotein [Homo sapiens] 80 8e-15
gi|38348414 von Willebrand factor C domain containing 2 [Homo sa... 79 2e-14
gi|134244285 Notch homolog 3 [Homo sapiens] 71 6e-12
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 70 1e-11
gi|56237021 fibrillin 3 precursor [Homo sapiens] 70 1e-11
gi|4557679 jagged 1 precursor [Homo sapiens] 69 2e-11
gi|169212026 PREDICTED: keratin associated protein [Homo sapiens] 69 2e-11
gi|169211819 PREDICTED: keratin associated protein [Homo sapiens] 68 4e-11
gi|239745811 PREDICTED: hypothetical protein XP_002343557 [Homo ... 68 4e-11
>gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]
Length = 1036
Score = 2298 bits (5955), Expect = 0.0
Identities = 1036/1036 (100%), Positives = 1036/1036 (100%)
Query: 1 MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVC 60
MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVC
Sbjct: 1 MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVC 60
Query: 61 GCCYTCASQRNESCGGTFGIYGTCDRGLRCVIRPPLNGDSLTEYEAGVCEDENWTDDQLL 120
GCCYTCASQRNESCGGTFGIYGTCDRGLRCVIRPPLNGDSLTEYEAGVCEDENWTDDQLL
Sbjct: 61 GCCYTCASQRNESCGGTFGIYGTCDRGLRCVIRPPLNGDSLTEYEAGVCEDENWTDDQLL 120
Query: 121 GFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE 180
GFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE
Sbjct: 121 GFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE 180
Query: 181 VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGE 240
VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGE
Sbjct: 181 VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGE 240
Query: 241 CCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSGLCGF 300
CCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSGLCGF
Sbjct: 241 CCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSGLCGF 300
Query: 301 PVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQ 360
PVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQ
Sbjct: 301 PVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQ 360
Query: 361 GGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDD 420
GGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDD
Sbjct: 361 GGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDD 420
Query: 421 CTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGK 480
CTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGK
Sbjct: 421 CTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGK 480
Query: 481 DCINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCR 540
DCINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCR
Sbjct: 481 DCINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCR 540
Query: 541 PIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAG 600
PIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAG
Sbjct: 541 PIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAG 600
Query: 601 PPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCP 660
PPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCP
Sbjct: 601 PPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCP 660
Query: 661 SCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLC 720
SCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLC
Sbjct: 661 SCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLC 720
Query: 721 QNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDS 780
QNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDS
Sbjct: 721 QNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDS 780
Query: 781 VISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHC 840
VISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHC
Sbjct: 781 VISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHC 840
Query: 841 YCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVP 900
YCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVP
Sbjct: 841 YCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVP 900
Query: 901 LWPTPSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFI 960
LWPTPSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFI
Sbjct: 901 LWPTPSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFI 960
Query: 961 NQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYS 1020
NQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYS
Sbjct: 961 NQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYS 1020
Query: 1021 MQKQNHLQADNFYQTV 1036
MQKQNHLQADNFYQTV
Sbjct: 1021 MQKQNHLQADNFYQTV 1036
>gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]
Length = 1503
Score = 224 bits (571), Expect = 3e-58
Identities = 158/591 (26%), Positives = 221/591 (37%), Gaps = 122/591 (20%)
Query: 336 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVY 395
C N Y +G+ F D C CRC G C C E+NC P GECCP+C
Sbjct: 138 CSQNGQTYGNGETFSPDACTTCRCLTGAVQCQGPSCSELNCLESCTPPGECCPIC----- 192
Query: 396 PFNNPAGCYANGLILAHGDRWRE--DDCTFCQCVNGERHCVATVCGQTCTNPVK-VPGEC 452
C G HG W D C C+C+ G C C C P + +PG C
Sbjct: 193 -------CTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYPARPLPGTC 245
Query: 453 CPVCEEPTIITVDPPACGELSNCTLTGKDCINGFK-RDHNGCRTCQCINTEELCSERKQG 511
CPVC+ C L G++ +G + C C+C N C E
Sbjct: 246 CPVCD----------------GCFLNGREHRSGEPVGSGDPCSHCRCANGSVQC-EPLPC 288
Query: 512 CTLNCPFGFLTDAQNCEICE-CRPRPKKCRPIICDKYCPLGLLKN---KHGCDICRCKKC 567
+ C Q C +C+ C + + + + GL + G C ++C
Sbjct: 289 PPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQEC 348
Query: 568 PELSCS------KICP------------LGFQQDSHGCLICKCREASASAG--------- 600
P C+ ++CP + ++ D C C C++ G
Sbjct: 349 PVTPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPC 408
Query: 601 --PPILSGTC------LTVDGHHHKNEESWHDG---CRECYCLNGREMCALITCPVPACG 649
P G C T + N +++ D C C+C +G C+L+ CP C
Sbjct: 409 QHPTQPPGACCPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCA 468
Query: 650 NPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVEGETWN--IDSCTQCTCHSGR 707
P PGQCCP C D + + E FV+GE+++ D C +C C G
Sbjct: 469 RPQSGPGQCCPRCPDCILEE---------------EVFVDGESFSHPRDPCQECRCQEGH 513
Query: 708 VLCETEVCPPLLCQNPSRTQDSCCP-QCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAES 766
C+ CP C +P +CCP C+ F P+ A+
Sbjct: 514 AHCQPRPCPRAPCAHP--LPGTCCPNDCSGCAF-----GGKEYPS-----------GADF 555
Query: 767 WKP-DVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKA 825
P D C C C+ + C + C + C PVL G+CCP C P C G A
Sbjct: 556 PHPSDPCRLCRCLSGNVQCLARRCVPLPCPEPVLLPGECCPQC-----PAPAGCPRPGAA 610
Query: 826 YADEERW---DLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMC 873
+A + + D C C CL G C + CPP PC P +G CCP C
Sbjct: 611 HARHQEYFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCAHP--RQGPCCPSC 659
Score = 208 bits (529), Expect = 2e-53
Identities = 212/849 (24%), Positives = 288/849 (33%), Gaps = 247/849 (29%)
Query: 168 EEEKPD-CSKARC---EVQFS-PRCPEDSVLIEGYAPPGECCPL---------------- 206
E PD C+ RC VQ P C E + L E PPGECCP+
Sbjct: 149 ETFSPDACTTCRCLTGAVQCQGPSCSELNCL-ESCTPPGECCPICCTEGGSHWEHGQEWT 207
Query: 207 -------PSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYE-C----------K 248
RC+ C ++ C ++ A PG CC + + C +
Sbjct: 208 TPGDPCRICRCLEGHIQCRQREC----ASLCPYPARPLPGTCCPVCDGCFLNGREHRSGE 263
Query: 249 PVFGVD----CR----TVECPPVQQTACPPDSYETQVRLTADGCCTLPTRCECLS----- 295
PV D CR +V+C P+ CPP ++ CC + CE
Sbjct: 264 PVGSGDPCSHCRCANGSVQCEPL---PCPPVPCRHPGKIPGQ-CCPVCDGCEYQGHQYQS 319
Query: 296 ---------GLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDG 346
GLC C+ G TP C + PAC + E+ +G
Sbjct: 320 QETFRLQERGLCVRCSCQAGEVSCEEQECPVTP---CALPASGRQLCPACELDGEEFAEG 376
Query: 347 DMFRMDN--CRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCY 404
+ D C C CQ GV C C C+ P G CCP C+ Y + Y
Sbjct: 377 VQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQPPGACCPSCDSCTY----HSQVY 432
Query: 405 ANGLILAHGDRWREDDCTFCQCVNGERHCVATVC-GQTCTNPVKVPGECCPVCEEPTIIT 463
ANG D C C C +G C C TC P PG+CCP C +
Sbjct: 433 ANGQNFTDAD----SPCHACHCQDGTVTCSLVDCPPTTCARPQSGPGQCCPRCPD----- 483
Query: 464 VDPPACGELSNCTLTGKDCING--FKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFL 521
C L + ++G F + C+ C+C C R
Sbjct: 484 -----------CILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRP------------ 520
Query: 522 TDAQNCEICEC-RPRPKKCRPIICDKYCPLGLLKNKHG---------CDICRC------- 564
C C P P C P C C G + G C +CRC
Sbjct: 521 -----CPRAPCAHPLPGTCCPNDCSG-CAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQC 574
Query: 565 --KKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESW 622
++C L C + L + C C + A AG C H +++E +
Sbjct: 575 LARRCVPLPCPEPVLLPGE-----C----CPQCPAPAG-------CPRPGAAHARHQEYF 618
Query: 623 H---DGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSIC 679
D CR C CL+G C + CP C +P G CCPSC D + Q E ++
Sbjct: 619 SPPGDPCRRCLCLDGSVSCQRLPCPPAPCAHP--RQGPCCPSC-DGCLYQGKEFAS---- 671
Query: 680 HAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPF 739
GE F +C C C G V CE + C P LC P+R CCP C +
Sbjct: 672 ----GERFPSPTA----ACHLCLCWEGSVSCEPKACAPALCPFPAR--GDCCPDCDGCEY 721
Query: 740 RPSLSRNNSVPNYCKNDEGDIFLAAESWKP--DVCTSCICIDSVISCFSESCPSVSCERP 797
G+ +L+ + + + C C C+ ++C C C P
Sbjct: 722 L-----------------GESYLSNQEFPDPREPCNLCTCLGGFVTCGRRPCEPPGCSHP 764
Query: 798 VLRKGQCCPYC-----------IEDTIPKKV----------------------------- 817
++ G CCP C +T+P +
Sbjct: 765 LIPSGHCCPTCQGCRYHGVTTASGETLPDPLDPTCSLCTCQEGSMRCQKKPCPPALCPHP 824
Query: 818 --------VCH---FSGKAYADEERWD--LDSCTHCYCLQGQTLCSTVSCPPLPCVEPIN 864
VCH G+ + D E ++ SC C C GQ C + CPPLPC +
Sbjct: 825 SPGPCFCPVCHSCLSQGREHQDGEEFEGPAGSCEWCRCQAGQVSCVRLQCPPLPCKLQVT 884
Query: 865 VEGSCCPMC 873
GSCCP C
Sbjct: 885 ERGSCCPRC 893
Score = 198 bits (504), Expect = 2e-50
Identities = 209/827 (25%), Positives = 272/827 (32%), Gaps = 233/827 (28%)
Query: 199 PPGECCPLPSRCVCNP-------------AGCLRKVCQPGNLNILVSKASGKPGECCDLY 245
PPG CCP C + + C CQ G + C L
Sbjct: 414 PPGACCPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVT-------------CSLV 460
Query: 246 ECKPVFGVDCRTVECPPVQQTA-CPPDSYETQVRLTADGCCTLPTRCECLSGLC--GFPV 302
+C P C + P Q CP E +V + DG R C C G
Sbjct: 461 DCPPT---TCARPQSGPGQCCPRCPDCILEEEVFV--DGESFSHPRDPCQECRCQEGHAH 515
Query: 303 CEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFR--MDNCRFCRCQ 360
C+ PR PG CC ND C F EY G F D CR CRC
Sbjct: 516 CQPRPCPRAPC-AHPLPGTCCP-----NDCS-GCAFGGKEYPSGADFPHPSDPCRLCRCL 568
Query: 361 GGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWRE-- 418
G C +C + C + GECCP C P AGC G A +
Sbjct: 569 SGNVQCLARRCVPLPCPEPVLLPGECCPQCPAP-------AGCPRPGAAHARHQEYFSPP 621
Query: 419 -DDCTFCQCVNGERHCVATVCGQT-CTNPVKVPGECCPVCE----------------EPT 460
D C C C++G C C C +P + G CCP C+ PT
Sbjct: 622 GDPCRRCLCLDGSVSCQRLPCPPAPCAHPRQ--GPCCPSCDGCLYQGKEFASGERFPSPT 679
Query: 461 I-----------ITVDPPACG--------------ELSNCTLTGKDCING--FKRDHNGC 493
++ +P AC + C G+ ++ F C
Sbjct: 680 AACHLCLCWEGSVSCEPKACAPALCPFPARGDCCPDCDGCEYLGESYLSNQEFPDPREPC 739
Query: 494 RTCQCINTEELCSERK---QGCT-------------LNCPFGFLTDAQN----------C 527
C C+ C R GC+ C + +T A C
Sbjct: 740 NLCTCLGGFVTCGRRPCEPPGCSHPLIPSGHCCPTCQGCRYHGVTTASGETLPDPLDPTC 799
Query: 528 EICEC-----RPRPKKCRPIICDK------YCPLGLLKNKHG---------------CDI 561
+C C R + K C P +C +CP+ G C+
Sbjct: 800 SLCTCQEGSMRCQKKPCPPALCPHPSPGPCFCPVCHSCLSQGREHQDGEEFEGPAGSCEW 859
Query: 562 CRCK----KCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHK 617
CRC+ C L C + P Q G +CR A G H
Sbjct: 860 CRCQAGQVSCVRLQCPPL-PCKLQVTERGSCCPRCRGCLAH--------------GEEHP 904
Query: 618 NEESW---HDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELS 674
W C C C G CA I C + +C P P CCP C+D
Sbjct: 905 EGSRWVPPDSACSSCVCHEGVVTCARIQC-ISSCAQPRQGPHDCCPQCSD---------- 953
Query: 675 TPSICHAPGGEYFVEGETWN--IDSCTQCTCHSG-----RVLCETEVCPPLLCQNPSRT- 726
C G +Y GE++ D C C C + C CP L+ PS+
Sbjct: 954 ----CEHEGRKY-EPGESFQPGADPCEVCICEPQPEGPPSLRCHRRQCPSLVGCPPSQLL 1008
Query: 727 ---QDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVIS 783
CCP C + +LS + EG L +E PD C +C C D
Sbjct: 1009 PPGPQHCCPTCAE-----ALSNCS---------EG--LLGSELAPPDPCYTCQCQDLTWL 1052
Query: 784 CFSESCPSVSCERPVLRK----GQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTH 839
C ++CP +SC P+ + G CCP C T C G+ A ERW +D+CT
Sbjct: 1053 CIHQACPELSC--PLSERHTPPGSCCPVCRAPTQS----CVHQGREVASGERWTVDTCTS 1106
Query: 840 CYCLQGQTLCSTVSCPPLPC---VEPINVEGSCCPMCPEMYVPEPTN 883
C C+ G C + C PL C P GSCCP C +P P +
Sbjct: 1107 CSCMAGTVRCQSQRCSPLSCGPDKAPALSPGSCCPRC----LPRPAS 1149
Score = 197 bits (502), Expect = 3e-50
Identities = 167/611 (27%), Positives = 217/611 (35%), Gaps = 162/611 (26%)
Query: 327 ECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGEC 386
EC + P C + +G + D C C CQ G A CG P+
Sbjct: 88 EC-HPASPQCWGLGRAWPEGARWEPDACTACVCQDGAA-----HCG---------PQAHL 132
Query: 387 CPVCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQ-TCTNP 445
P C GC NG +G+ + D CT C+C+ G C C + C
Sbjct: 133 -PHCR----------GCSQNGQTYGNGETFSPDACTTCRCLTGAVQCQGPSCSELNCLES 181
Query: 446 VKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNG--CRTCQCINTEE 503
PGECCP+C CT G +G + G CR C+C+
Sbjct: 182 CTPPGECCPIC------------------CTEGGSHWEHGQEWTTPGDPCRICRCLEGHI 223
Query: 504 LCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHG----- 558
C +R+ C CP+ RP P C P+ CD C L +++ G
Sbjct: 224 QCRQRE--CASLCPY------------PARPLPGTCCPV-CDG-CFLNGREHRSGEPVGS 267
Query: 559 ---CDICRCKK---------CPELSC-------SKICPL-------GFQQDSHG------ 586
C CRC CP + C + CP+ G Q S
Sbjct: 268 GDPCSHCRCANGSVQCEPLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQE 327
Query: 587 ---CLICKCREASASAGP---PIL------SGTCLT----VDGHHHKNEESWH-DG--CR 627
C+ C C+ S P+ SG L +DG W DG C
Sbjct: 328 RGLCVRCSCQAGEVSCEEQECPVTPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPCT 387
Query: 628 ECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYF 687
C C +G C + CP C +PT PG CCPSC + S +A G+ F
Sbjct: 388 ACVCQDGVPKCGAVLCPPAPCQHPTQPPGACCPSC--------DSCTYHSQVYA-NGQNF 438
Query: 688 VEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSLSRNN 747
+ ++ C C C G V C CPP C P CCP+C D
Sbjct: 439 TDADS----PCHACHCQDGTVTCSLVDCPPTTCARPQSGPGQCCPRCPD----------- 483
Query: 748 SVPNYCKNDEGDIFLAAESWKP--DVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCC 805
C +E ++F+ ES+ D C C C + C CP C P+ G CC
Sbjct: 484 -----CILEE-EVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHPL--PGTCC 535
Query: 806 PYCIEDTIPKKVVCHFSGKAYADEERWD--LDSCTHCYCLQGQTLCSTVSCPPLPCVEPI 863
P C F GK Y + D C C CL G C C PLPC EP+
Sbjct: 536 PNDCSG-------CAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARRCVPLPCPEPV 588
Query: 864 NVEGSCCPMCP 874
+ G CCP CP
Sbjct: 589 LLPGECCPQCP 599
Score = 190 bits (483), Expect = 5e-48
Identities = 140/512 (27%), Positives = 192/512 (37%), Gaps = 131/512 (25%)
Query: 403 CYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTII 462
C+ G G RW D CT C C +G HC P P C
Sbjct: 96 CWGLGRAWPEGARWEPDACTACVCQDGAAHCG--------------PQAHLPHCR----- 136
Query: 463 TVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELCSERKQGCT-LNCPFGFL 521
C+ G+ NG + C TC+C+ C + C+ LNC
Sbjct: 137 -----------GCSQNGQTYGNGETFSPDACTTCRCLTGAVQC--QGPSCSELNC----- 178
Query: 522 TDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHG---------CDICRCKK----CP 568
+ C P P +C PI C + G +HG C ICRC + C
Sbjct: 179 -------LESCTP-PGECCPICCTE----GGSHWEHGQEWTTPGDPCRICRCLEGHIQCR 226
Query: 569 ELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDG--C 626
+ C+ +CP + C P+ G L +G H++ E G C
Sbjct: 227 QRECASLCPYPARPLPGTCC-------------PVCDGCFL--NGREHRSGEPVGSGDPC 271
Query: 627 RECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEY 686
C C NG C + CP C +P PGQCCP C C G +Y
Sbjct: 272 SHCRCANGSVQCEPLPCPPVPCRHPGKIPGQCCPVCDG--------------CEYQGHQY 317
Query: 687 FVEGETWNIDS---CTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSL 743
+ ET+ + C +C+C +G V CE + CP C P+ + CP C
Sbjct: 318 QSQ-ETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPASGRQ-LCPAC--------- 366
Query: 744 SRNNSVPNYCKNDEGDIFLAAESWKPD--VCTSCICIDSVISCFSESCPSVSCERPVLRK 801
+G+ F W+PD CT+C+C D V C + CP C+ P
Sbjct: 367 -----------ELDGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQPP 415
Query: 802 GQCCPYCIEDTIPKKVVCHFSGKAYADEERW-DLDS-CTHCYCLQGQTLCSTVSCPPLPC 859
G CCP C C + + YA+ + + D DS C C+C G CS V CPP C
Sbjct: 416 GACCPSCDS--------CTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTC 467
Query: 860 VEPINVEGSCCPMCPEMYVPEPTNIPIEKTNH 891
P + G CCP CP+ + E + E +H
Sbjct: 468 ARPQSGPGQCCPRCPDCILEEEVFVDGESFSH 499
Score = 155 bits (392), Expect = 2e-37
Identities = 170/661 (25%), Positives = 229/661 (34%), Gaps = 206/661 (31%)
Query: 187 CPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYE 246
CPE +L PGECCP +C PAGC R PG + + PG+ C
Sbjct: 584 CPEPVLL------PGECCP---QCPA-PAGCPR----PGAAHARHQEYFSPPGDPCRRCL 629
Query: 247 CKPVFGVDCRTVECPPV------QQTACPP-DSYETQVRLTADG--------------CC 285
C V C+ + CPP Q CP D Q + A G C
Sbjct: 630 CLDG-SVSCQRLPCPPAPCAHPRQGPCCPSCDGCLYQGKEFASGERFPSPTAACHLCLCW 688
Query: 286 TLPTRCE---CLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVE 342
CE C LC FP +RGD P CD E + ++ +N E
Sbjct: 689 EGSVSCEPKACAPALCPFP-----------ARGDCCPD--CDGCEYLGES----YLSNQE 731
Query: 343 YYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCE----------- 391
+ D + C C C GG C C C +P G CCP C+
Sbjct: 732 FPDP----REPCNLCTCLGGFVTCGRRPCEPPGCSHPLIPSGHCCPTCQGCRYHGVTTAS 787
Query: 392 -----DPV---------------------------YPFNNPAGCYANGLILAHGDRWRED 419
DP+ +P P C L+ G ++
Sbjct: 788 GETLPDPLDPTCSLCTCQEGSMRCQKKPCPPALCPHPSPGPCFCPVCHSCLSQGREHQDG 847
Query: 420 D--------CTFCQCVNGERHCVATVCGQT-CTNPVKVPGECCPVC--------EEPTII 462
+ C +C+C G+ CV C C V G CCP C E P
Sbjct: 848 EEFEGPAGSCEWCRCQAGQVSCVRLQCPPLPCKLQVTERGSCCPRCRGCLAHGEEHPEGS 907
Query: 463 TVDPP--ACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPF-- 518
PP AC S+C H G TC I C++ +QG CP
Sbjct: 908 RWVPPDSAC---SSCVC------------HEGVVTCARIQCISSCAQPRQGPHDCCPQCS 952
Query: 519 -------------GFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCK 565
F A CE+C C P+P+ + C + +
Sbjct: 953 DCEHEGRKYEPGESFQPGADPCEVCICEPQPEGPPSLRCHR------------------R 994
Query: 566 KCPEL-SC--SKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESW 622
+CP L C S++ P G Q H C C EA ++ +L +E +
Sbjct: 995 QCPSLVGCPPSQLLPPGPQ---HCCPTCA--EALSNCSEGLLG------------SELAP 1037
Query: 623 HDGCRECYCLNGREMCALITCPVPACGNPTIH--PGQCCPSCADDFVVQKPELSTPSICH 680
D C C C + +C CP +C H PG CCP C T S H
Sbjct: 1038 PDPCYTCQCQDLTWLCIHQACPELSCPLSERHTPPGSCCPVC---------RAPTQSCVH 1088
Query: 681 APGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLC---QNPSRTQDSCCPQCTDQ 737
G GE W +D+CT C+C +G V C+++ C PL C + P+ + SCCP+C +
Sbjct: 1089 Q--GREVASGERWTVDTCTSCSCMAGTVRCQSQRCSPLSCGPDKAPALSPGSCCPRCLPR 1146
Query: 738 P 738
P
Sbjct: 1147 P 1147
>gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]
Length = 814
Score = 209 bits (531), Expect = 1e-53
Identities = 174/701 (24%), Positives = 236/701 (33%), Gaps = 166/701 (23%)
Query: 272 SYETQVRLTADGCCTLPTRCECLSGL--CGFPVCEVGSTPRIVSRGDGTPGKCCDVFECV 329
+Y + D C T C CL G C C G P PG CC
Sbjct: 144 TYGNGETFSPDACTT----CRCLEGTITCNQKPCPRGPCPE--------PGACCP----- 186
Query: 330 NDTKPACVFNNVEYYDGDMFRMDN--CRFCRCQGGVAICFTAQCGEINCERYYVPEGECC 387
KP C + Y +G F + C C C C +C C + G CC
Sbjct: 187 -HCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALKCPPSPCPEPVLRPGHCC 245
Query: 388 PVCEDPVYPFNNPAGCYANGLILAHGDRWRE--DDCTFCQCVNGERHCVATVCGQTCTNP 445
P C+ GC G HG W D C C+C+ G C C C P
Sbjct: 246 PTCQ----------GCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYP 295
Query: 446 VK-VPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFK-RDHNGCRTCQCINTEE 503
+ +PG CCPVC+ C L G++ +G + C C+C N
Sbjct: 296 ARPLPGTCCPVCD----------------GCFLNGREHRSGEPVGSGDPCSHCRCANGSV 339
Query: 504 LCSERKQGCTLNCPFGFLTDAQNCEICE-CRPRPKKCRPIICDKYCPLGLLKN---KHGC 559
C E + C Q C +C+ C + + + + GL + G
Sbjct: 340 QC-EPLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGE 398
Query: 560 DICRCKKCPELSCS------KICP------------LGFQQDSHGCLICKCREASASAG- 600
C ++CP C+ ++CP + ++ D C C C++ G
Sbjct: 399 VSCEEQECPVTPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQDGVPKCGA 458
Query: 601 ----------PPILSGTCL------TVDGHHHKNEESWHDG---CRECYCLNGREMCALI 641
P G C T + N +++ D C C+C +G C+L+
Sbjct: 459 VLCPPAPCQHPTQPPGACCPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLV 518
Query: 642 TCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICH--------------------- 680
CP C P PGQCCP C D + ++ + S H
Sbjct: 519 DCPPTTCARPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRP 578
Query: 681 ----------------------APGGEYFVEGETWN--IDSCTQCTCHSGRVLCETEVCP 716
A GG+ + G + D C C C SG V C C
Sbjct: 579 CPRAPCAHPLPGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARRCV 638
Query: 717 PLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKP--DVCTS 774
PL C P CCPQC P P C E + P D C
Sbjct: 639 PLPCPEPVLLPGECCPQCPAAP----------APAGCPRPGAAHARHQEYFSPPGDPCRR 688
Query: 775 CICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDL 834
C+C+D +SC CP C P R+G CCP C C + GK +A ER+
Sbjct: 689 CLCLDGSVSCQRLPCPPAPCAHP--RQGPCCPSCDG--------CLYQGKEFASGERFPS 738
Query: 835 DS--CTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMC 873
+ C C C +G C +C P C P G CCP C
Sbjct: 739 PTAACHLCLCWEGSVSCEPKACAPALC--PFPARGDCCPDC 777
Score = 203 bits (517), Expect = 6e-52
Identities = 160/591 (27%), Positives = 218/591 (36%), Gaps = 147/591 (24%)
Query: 327 ECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGEC 386
EC + P C + +G + D C C CQ G A CG P+
Sbjct: 88 EC-HPASPQCWGLGRAWPEGARWEPDACTACVCQDGAA-----HCG---------PQAHL 132
Query: 387 CPVCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPV 446
P C GC NG +G+ + D CT C+C+ G C C + P
Sbjct: 133 -PHCR----------GCSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPR---GPC 178
Query: 447 KVPGECCPVCEEPTIITVDPPAC---GELSNCTLTGKDCINGFKRDHNGCRTCQCINTEE 503
PG CCP C+ P C G+L +T F N C C C+ +
Sbjct: 179 PEPGACCPHCK---------PGCDYEGQLYEEGVT-------FLSSSNPCLQCTCLRSRV 222
Query: 504 LCSERKQGCTLN-CPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHG---- 558
C K C + CP L C C+ C G +HG
Sbjct: 223 RCMALK--CPPSPCPEPVLRPGHCCPTCQ---------------GCTEGGSHWEHGQEWT 265
Query: 559 -----CDICRCK----KCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCL 609
C ICRC +C + C+ +CP + C P+ G L
Sbjct: 266 TPGDPCRICRCLEGHIQCRQRECASLCPYPARPLPGTCC-------------PVCDGCFL 312
Query: 610 TVDGHHHKNEESWHDG--CRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFV 667
+G H++ E G C C C NG C + CP C +P PGQCCP C
Sbjct: 313 --NGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVPCRHPGKIPGQCCPVCDG--- 367
Query: 668 VQKPELSTPSICHAPGGEYFVEGETWNIDS---CTQCTCHSGRVLCETEVCPPLLCQNPS 724
C G +Y + ET+ + C +C+C +G V CE + CP C P+
Sbjct: 368 -----------CEYQGHQYQSQ-ETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPA 415
Query: 725 RTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPD--VCTSCICIDSVI 782
+ CP C +G+ F W+PD CT+C+C D V
Sbjct: 416 SGR-QLCPAC--------------------ELDGEEFAEGVQWEPDGRPCTACVCQDGVP 454
Query: 783 SCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERW-DLDS-CTHC 840
C + CP C+ P G CCP C C + + YA+ + + D DS C C
Sbjct: 455 KCGAVLCPPAPCQHPTQPPGACCPSCDS--------CTYHSQVYANGQNFTDADSPCHAC 506
Query: 841 YCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNH 891
+C G CS V CPP C P + G CCP CP+ + E + E +H
Sbjct: 507 HCQDGTVTCSLVDCPPTTCARPQSGPGQCCPRCPDCILEEEVFVDGESFSH 557
Score = 156 bits (394), Expect = 1e-37
Identities = 154/579 (26%), Positives = 196/579 (33%), Gaps = 145/579 (25%)
Query: 200 PGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKP---GECCDLYECKPVFGVDCR 256
PG CCP+ C N SG+P G+ C C V C
Sbjct: 300 PGTCCPVCDGCFLNGR----------------EHRSGEPVGSGDPCSHCRCANG-SVQCE 342
Query: 257 TVECPPVQ--------QTACPP--------DSYETQ--VRLTADGCCTLPTRCECLSGLC 298
+ CPPV CP Y++Q RL G C RC C +G
Sbjct: 343 PLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCV---RCSCQAGEV 399
Query: 299 GFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDN--CRF 356
E TP C + PAC + E+ +G + D C
Sbjct: 400 SCEEQECPVTP-------------CALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTA 446
Query: 357 CRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRW 416
C CQ GV C C C+ P G CCP C+ Y + YANG D
Sbjct: 447 CVCQDGVPKCGAVLCPPAPCQHPTQPPGACCPSCDSCTYH----SQVYANGQNFTDAD-- 500
Query: 417 REDDCTFCQCVNGERHCVATVCGQT-CTNPVKVPGECCPVCEEPTIITVDPPACGELSNC 475
C C C +G C C T C P PG+CCP C + C
Sbjct: 501 --SPCHACHCQDGTVTCSLVDCPPTTCARPQSGPGQCCPRCPD----------------C 542
Query: 476 TLTGKDCING--FKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICEC- 532
L + ++G F + C+ C+C C R C C
Sbjct: 543 ILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRP-----------------CPRAPCA 585
Query: 533 RPRPKKCRPIICDKYCPLGLLKNKHG---------CDICRCK----KCPELSCSKI-CPL 578
P P C P C C G + G C +CRC +C C + CP
Sbjct: 586 HPLPGTCCPNDCSG-CAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARRCVPLPCPE 644
Query: 579 GFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWH---DGCRECYCLNGR 635
C +C A A AG C H +++E + D CR C CL+G
Sbjct: 645 PVLLPGECCP--QCPAAPAPAG-------CPRPGAAHARHQEYFSPPGDPCRRCLCLDGS 695
Query: 636 EMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVEGETWNI 695
C + CP C +P G CCPSC D + Q E ++ GE F
Sbjct: 696 VSCQRLPCPPAPCAHP--RQGPCCPSC-DGCLYQGKEFAS--------GERFPSPTA--- 741
Query: 696 DSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQC 734
+C C C G V CE + C P LC P+R CCP C
Sbjct: 742 -ACHLCLCWEGSVSCEPKACAPALCPFPAR--GDCCPDC 777
Score = 91.3 bits (225), Expect = 4e-18
Identities = 104/383 (27%), Positives = 129/383 (33%), Gaps = 81/383 (21%)
Query: 199 PPGECCPLPSRCVCN-------------PAGCLRKVCQPGNLNILVSKASGKPGECCDLY 245
PPG CCP C + + C CQ G + C L
Sbjct: 472 PPGACCPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVT-------------CSLV 518
Query: 246 ECKPVFGVDCRTVECPPVQQTACP--PDSYETQVRLTADGCCTLPTRCECLSGLC--GFP 301
+C P C + P Q CP PD + + DG R C C G
Sbjct: 519 DCPP---TTCARPQSGPGQ--CCPRCPDCI-LEEEVFVDGESFSHPRDPCQECRCQEGHA 572
Query: 302 VCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMF--RMDNCRFCRC 359
C+ PR PG CC ND C F EY G F D CR CRC
Sbjct: 573 HCQPRPCPR-APCAHPLPGTCCP-----NDCS-GCAFGGKEYPSGADFPHPSDPCRLCRC 625
Query: 360 QGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWRE- 418
G C +C + C + GECCP C P P PAGC G A +
Sbjct: 626 LSGNVQCLARRCVPLPCPEPVLLPGECCPQC--PAAP--APAGCPRPGAAHARHQEYFSP 681
Query: 419 --DDCTFCQCVNGERHCVATVCGQT-CTNPVKVPGECCPVCEEPTIITVDPPACGELSNC 475
D C C C++G C C C +P + G CCP C+ C
Sbjct: 682 PGDPCRRCLCLDGSVSCQRLPCPPAPCAHPRQ--GPCCPSCD----------------GC 723
Query: 476 TLTGKDCING--FKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTD-AQNCE---- 528
GK+ +G F C C C C E K CPF D +C+
Sbjct: 724 LYQGKEFASGERFPSPTAACHLCLCWEGSVSC-EPKACAPALCPFPARGDCCPDCDGEGH 782
Query: 529 -ICECRPRPKKCRPIICDK-YCP 549
I CR ++ R + + YCP
Sbjct: 783 GIGSCRGGMRETRGLGQNNLYCP 805
Score = 66.2 bits (160), Expect = 1e-10
Identities = 102/443 (23%), Positives = 131/443 (29%), Gaps = 150/443 (33%)
Query: 40 CDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRCVIRPPLNGD 99
C + C+ P PG+ CC +C D
Sbjct: 461 CPPAPCQHPTQPPGA-------CCPSC--------------------------------D 481
Query: 100 SLTEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTI----RTCSNPFEFP 155
S T + +N+TD PC+ C+ +G C+ + TC+ P P
Sbjct: 482 SCTYHSQVYANGQNFTDAD----SPCH-----ACHCQDGTVTCSLVDCPPTTCARPQSGP 532
Query: 156 SQDMCLSALKRIEEEKPDCSKARCEVQFSPRCP----EDSVLIEGYA------PPGECCP 205
Q PRCP E+ V ++G + P EC
Sbjct: 533 G-------------------------QCCPRCPDCILEEEVFVDGESFSHPRDPCQECRC 567
Query: 206 LPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQ 265
C P C R C A PG CC +C G E P
Sbjct: 568 QEGHAHCQPRPCPRAPC-----------AHPLPGTCCP-NDCS---GCAFGGKEYPSGAD 612
Query: 266 TACPPDSYETQVRLTADGCCTLPTRCECLSG--LCGFPVCEVGSTPRIVSRGDGTPGKCC 323
P D C L C CLSG C C P V PG+CC
Sbjct: 613 FPHPSDP------------CRL---CRCLSGNVQCLARRCVPLPCPEPVL----LPGECC 653
Query: 324 DVFECVNDTKP-------ACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINC 376
+C P A + EY+ D CR C C G C C C
Sbjct: 654 P--QCPAAPAPAGCPRPGAAHARHQEYFSPP---GDPCRRCLCLDGSVSCQRLPCPPAPC 708
Query: 377 ERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDD--CTFCQCVNGERHCV 434
+ +G CCP C+ GC G A G+R+ C C C G C
Sbjct: 709 A--HPRQGPCCPSCD----------GCLYQGKEFASGERFPSPTAACHLCLCWEGSVSCE 756
Query: 435 ATVCGQTCTNPVKVPGECCPVCE 457
C P G+CCP C+
Sbjct: 757 PKACAPALC-PFPARGDCCPDCD 778
>gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
Length = 810
Score = 148 bits (373), Expect = 3e-35
Identities = 166/670 (24%), Positives = 238/670 (35%), Gaps = 178/670 (26%)
Query: 220 KVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRL 279
K CQ L + + S G+ C CK V+CR + CPP+ C PDS +
Sbjct: 271 KTCQVSGL-LYRDQDSWVDGDHCRNCTCKSG-AVECRRMSCPPLN---CSPDSLPVHIA- 324
Query: 280 TADGCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFN 339
G+CC V +P C++
Sbjct: 325 ----------------------------------------GQCCKV------CRPKCIYG 338
Query: 340 NVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCER--YYVPEGECCPVCEDPVY-- 395
+G +CR CR GGV + T C +NC + +PE +CC VC +
Sbjct: 339 GKVLAEGQRILTKSCRECR--GGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCA 396
Query: 396 ------------PFNNPAGCYA-NGLILAHGDRWREDDCTFCQCVNGERHCVA-TVCGQT 441
+N A C +G I GD +D +C +C A TVC
Sbjct: 397 EGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDID--ECAAKMHYCHANTVC--- 451
Query: 442 CTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINT 501
V +PG C P I VD +C E C +C D N
Sbjct: 452 ----VNLPGLYRCDCV-PGYIRVDDFSCTEHDECGSGQHNC------DENA--------- 491
Query: 502 EELCSERKQGCTLNCPFGFLTDAQNCE-ICE--CRPRPKKCRPIICDKYCPLGLLKNKHG 558
+C+ QG + C G++ + C CE CR P C CP G +
Sbjct: 492 --ICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC--VCPSGFTGSHCE 547
Query: 559 CDICRCKK----CPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSG-TCLTVDG 613
DI C + C S P G C+CR G LSG +C+ +D
Sbjct: 548 KDIDECSEGIIECHNHSRCVNLP--------GWYHCECRSGFHDDGTYSLSGESCIDIDE 599
Query: 614 HHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPEL 673
+ W+D C L G C CP PSC+ D
Sbjct: 600 CALRTHTCWNDSA--CINLAGGFDCL---CPSG-------------PSCSGD-------- 633
Query: 674 STPSICHAPGGEYFVEGETWNI--DSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCC 731
C GG G+ W + D C+ C+C G++ C C CQNPS CC
Sbjct: 634 -----CPHEGGLKH-NGQVWTLKEDRCSVCSCKDGKIFCRRTACD---CQNPSADL-FCC 683
Query: 732 PQCTDQPFRPSLSRNNSVPNYCKNDEGD-IFLAAESWKPDVCTSCICIDSVISCFSESCP 790
P+C + V + C + G ++ + ++W C C C++ + C+ +CP
Sbjct: 684 PEC-----------DTRVTSQCLDQNGHKLYRSGDNWTHS-CQQCRCLEGEVDCWPLTCP 731
Query: 791 SVSCERPVLRKGQCCPYCIED-------TIPKKVVCHFS-GKAYADEERWDL--DSCTHC 840
++SCE + +G+CCP C+ D T + C S G + W + CT C
Sbjct: 732 NLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTC 791
Query: 841 YCLQGQTLCS 850
C G+ CS
Sbjct: 792 KCKNGRVCCS 801
Score = 115 bits (289), Expect = 2e-25
Identities = 136/562 (24%), Positives = 198/562 (35%), Gaps = 109/562 (19%)
Query: 336 CVFNNVEYYDGDMF-RMDNCRFCRCQGGVAICFTAQCGEINCERYYVP---EGECCPVCE 391
C + + Y D D + D+CR C C+ G C C +NC +P G+CC VC
Sbjct: 273 CQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCR 332
Query: 392 DPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQ---CVNGERHCVATVCGQTCTNPVKV 448
C G +LA G R C C+ V C C + + +
Sbjct: 333 PK---------CIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEK--DHILP 381
Query: 449 PGECCPVCEEPTIITVDPPACGELSNC----TLTGKDCINGFKRDHNGCRTCQCINTEEL 504
+CC VC + P CGE S C T +C +G+ C+ I+
Sbjct: 382 ENQCCRVCRGHNFCA-EGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDE--- 437
Query: 505 CSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCD---I 561
C+ + C N + C+C P + C ++ G +H CD I
Sbjct: 438 CAAKMHYCHANT---VCVNLPGLYRCDCVPGYIRVDDFSCTEHDECG--SGQHNCDENAI 492
Query: 562 CRCKKCPELSCSKICPLGFQQDSHGCLICK--CREASASAGPPILSGTCLTVDG----HH 615
C SC+ C G+ + IC+ C E G + C+ G H
Sbjct: 493 CT-NTVQGHSCT--CKPGYVGNG---TICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHC 546
Query: 616 HKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELST 675
K+ + +G EC+ C + P + +C DD
Sbjct: 547 EKDIDECSEGIIECH---NHSRCVNL---------PGWYHCECRSGFHDD---------- 584
Query: 676 PSICHAPGGEYFVEGETW-NIDSCTQCTCHSGRVLCETEVC-PPLLCQNPSRTQDSCCPQ 733
G Y + GE+ +ID C T C C N + D CP
Sbjct: 585 --------GTYSLSGESCIDIDECA----------LRTHTCWNDSACINLAGGFDCLCPS 626
Query: 734 CTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESW--KPDVCTSCICIDSVISCFSESCPS 791
PS S + C + EG + + W K D C+ C C D I C +C
Sbjct: 627 ------GPSCSGD------CPH-EGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTAC-- 671
Query: 792 VSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCST 851
C+ P CCP C + + + + K Y + W SC C CL+G+ C
Sbjct: 672 -DCQNPSADLF-CCPEC-DTRVTSQCLDQNGHKLYRSGDNWT-HSCQQCRCLEGEVDCWP 727
Query: 852 VSCPPLPCVEPINVEGSCCPMC 873
++CP L C +EG CCP C
Sbjct: 728 LTCPNLSCEYTAILEGECCPRC 749
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/147 (27%), Positives = 53/147 (36%), Gaps = 29/147 (19%)
Query: 673 LSTPSICHAP-----GGEYFVEGETW-NIDSCTQCTCHSGRVLCETEVCPPLLCQN---P 723
LS CH G + + ++W + D C CTC SG V C CPPL C P
Sbjct: 261 LSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLP 320
Query: 724 SRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVIS 783
CC C RP V AE + + C V+
Sbjct: 321 VHIAGQCCKVC-----RPKCIYGGKV-------------LAEGQRILTKSCRECRGGVLV 362
Query: 784 CFSESCPSVSCERP--VLRKGQCCPYC 808
+E CP ++C +L + QCC C
Sbjct: 363 KITEMCPPLNCSEKDHILPENQCCRVC 389
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 145 bits (366), Expect = 2e-34
Identities = 145/578 (25%), Positives = 202/578 (34%), Gaps = 100/578 (17%)
Query: 335 ACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINC-----ERYYVPEGECCPV 389
ACV+ + D +++ D+C+ CRC G + IC A C C E + +CCP
Sbjct: 27 ACVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCPE 86
Query: 390 CEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKV- 448
C P C+ I HG W C+ C C +GE C C ++
Sbjct: 87 C-----VLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELA 141
Query: 449 ---PGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELC 505
G CCPVC G C+ G +G + C C C N C
Sbjct: 142 FIPEGSCCPVC------------VGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQC 189
Query: 506 SERKQGCTLNCPFGFLTDAQNCEICECRPR-PKKCRPIICDKYCPLGLLKNKHG------ 558
T C F C E R P KC P + C +HG
Sbjct: 190 ------FTAQCQPLF------CNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSEN 237
Query: 559 -CDICRCK----KCPELSCSKI-CPLG-FQQDSHGCLICKCREASASAGPPILSGTCLTV 611
C C C +C + +C + C G + HG +C E S +G+C +
Sbjct: 238 ACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHG----QCCEECVSP-----AGSC-SY 287
Query: 612 DGHHHKNEESWH-DGCRECYCLNGREMCALITCPVPACG--NPTIH-PGQCCPSC--ADD 665
DG +E W C C C +G+ C C C IH G+CCP C +
Sbjct: 288 DGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNG 347
Query: 666 FVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPS- 724
+ V + E +A + EGE W C C C +V C CPP +
Sbjct: 348 YCVYE-ETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLAL 406
Query: 725 RTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVC--------TSCI 776
+ CCP CT P + P++C + L W C + C+
Sbjct: 407 EVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCL 466
Query: 777 CIDSVISCFSESCPSVSCERPVL-RKGQCCPYCIEDTIPKK---VVCHFSGKAYADEERW 832
S + SC+ P+L R GQC P C + + VCH
Sbjct: 467 ACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCH------------ 514
Query: 833 DLDSCTHCYCLQGQTLCSTVSC-PPLPCVEPINVEGSC 869
+SC C+ G T ++C PL + E SC
Sbjct: 515 --ESCAGCW---GPTEKHCLACRDPLHVLRDGGCESSC 547
Score = 142 bits (359), Expect = 1e-33
Identities = 123/514 (23%), Positives = 177/514 (34%), Gaps = 122/514 (23%)
Query: 384 GECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVC-GQTC 442
G + E V P ++ C +LA W+ D C C+C H +C C
Sbjct: 9 GLALALAEFAVLPHHSEGACVYQDSLLADATIWKPDSCQSCRC-----HGDIVICKPAVC 63
Query: 443 TNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTE 502
NP +C E+ ++ + C C C + T
Sbjct: 64 RNP-----QC--AFEKGEVLQIAANQC-----------------------CPEC-VLRTP 92
Query: 503 ELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDIC 562
C K+ G + C +C C +C P C
Sbjct: 93 GSCHHEKK----IHEHGTEWASSPCSVCSCNHGEVRCTPQPC------------------ 130
Query: 563 RCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESW 622
P LSC L F + C +C G P + +GH ++ E W
Sbjct: 131 -----PPLSCGH-QELAFIPEGSCCPVC------VGLGKP------CSYEGHVFQDGEDW 172
Query: 623 H-DGCRECYCLNGREMCALITCPVPACGNPTI---HPGQCCPSCADDFVVQKPELSTPSI 678
C +C C NG C C C PG+CCP C +
Sbjct: 173 RLSRCAKCLCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQC------------SARS 220
Query: 679 CHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLC---QNPSRTQDSCCPQCT 735
C A G+ + GE W+ ++CT C C G V C + C PL C Q+ +R CC +C
Sbjct: 221 CSA-AGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECV 279
Query: 736 DQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCE 795
S C D G + E WK C C+C ++C + C V C
Sbjct: 280 ------------SPAGSCSYD-GVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECA 326
Query: 796 RP---VLRKGQCCP-------YCIEDTIPKKVVCHFSG-KAYADEERWDLDSCTHCYCLQ 844
R + G+CCP YC+ + + + + S K + E+W+ C C C
Sbjct: 327 RDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRG 386
Query: 845 GQTLCSTVSCPPLPC-VEPINVEGSCCPMCPEMY 877
Q C SCPP P + V+G CCP C ++
Sbjct: 387 AQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVH 420
Score = 132 bits (331), Expect = 2e-30
Identities = 166/689 (24%), Positives = 225/689 (32%), Gaps = 165/689 (23%)
Query: 276 QVRLTADGCCTLPTRCE----------CLSGLCGFPVC--EVGSTPRIVSRGDGTPGKCC 323
Q L AD P C+ C +C P C E G +I + +CC
Sbjct: 31 QDSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAAN------QCC 84
Query: 324 DVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINC---ERYY 380
ECV T +C + G + C C C G C C ++C E +
Sbjct: 85 P--ECVLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELAF 142
Query: 381 VPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQ 440
+PEG CCPVC P C G + G+ WR C C C NG C C
Sbjct: 143 IPEGSCCPVCVGLGKP------CSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQP 196
Query: 441 TCTNP----VKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTC 496
N V+VPG+CCP C +C+ G+ +G + N C TC
Sbjct: 197 LFCNQDETVVRVPGKCCPQC--------------SARSCSAAGQVYEHGEQWSENACTTC 242
Query: 497 QCINTEELCSERKQGC-TLNCPFGFLTDAQNCEICECRPRP------------------- 536
C E C KQ C L C G ++ + CE P
Sbjct: 243 ICDRGEVRC--HKQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWKG 300
Query: 537 KKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREAS 596
C +CD HG C+ +C ++ C++ L D C C R
Sbjct: 301 SACEFCMCD-----------HGQVTCQTGECAKVECARDEEL-IHLDGKCCPECISRNGY 348
Query: 597 ASAGPPILSGTCLTVDGHHHK---NEESWHDG-CRECYCLNGREMCALITCPVPACGNPT 652
+G ++ + K E W DG C+ C C + C +CP G
Sbjct: 349 CVYEE---TGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLA 405
Query: 653 IH-PGQCCPSCADDFVVQKPELST----PSICHAPGGEYFVEGETWNIDSC--------- 698
+ GQCCP C V P+ T P C + W + SC
Sbjct: 406 LEVKGQCCPDCTS--VHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGS 463
Query: 699 ------TQC-TCHSGRVLCETEVC-PPLLCQNPSRTQDSCCPQCTDQPFRPSLSRN---- 746
QC TC SG E C PPLL ++ C P C D ++ S
Sbjct: 464 LCLACQPQCSTCTSG---LECSSCQPPLLMRH-----GQCVPTCGDGFYQDRHSCAVCHE 515
Query: 747 ------NSVPNYCKNDEGDIFLAAESWKPDVC---------TSCICIDSVISCFSESCPS 791
+C + + + C T C S SC S
Sbjct: 516 SCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRC 575
Query: 792 VSC-ERPVLRKGQCCPYC----IEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQ 846
++C E+ VL G+C C D + VCH +SC C G
Sbjct: 576 LTCTEKTVLHDGKCMSECPGGYYADATGRCKVCH--------------NSCASC---SGP 618
Query: 847 TLCSTVSCPPLPCVEPINVEGSCCPMCPE 875
T +C P + +G C P C E
Sbjct: 619 TPSHCTACSPPKALR----QGHCLPRCGE 643
Score = 104 bits (259), Expect = 5e-22
Identities = 162/737 (21%), Positives = 238/737 (32%), Gaps = 189/737 (25%)
Query: 174 CSKARCEVQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSK 233
C A+C+ F C +D ++ PG+CCP S C+ AG + + + + N
Sbjct: 189 CFTAQCQPLF---CNQDETVVR---VPGKCCPQCSARSCSAAGQVYEHGEQWSENA---- 238
Query: 234 ASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPTRCEC 293
C T C +VR C LP RC
Sbjct: 239 ---------------------CTTCICD------------RGEVRCHKQAC--LPLRC-- 261
Query: 294 LSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDN 353
G R G+CC+ ECV+ +C ++ V Y +M++
Sbjct: 262 ------------GKGQSRARR----HGQCCE--ECVSPA-GSCSYDGVVRYQDEMWKGSA 302
Query: 354 CRFCRCQGGVAICFTAQCGEINC---ERYYVPEGECCPVC-EDPVYPFNNPAGCYANGLI 409
C FC C G C T +C ++ C E +G+CCP C Y G + +
Sbjct: 303 CEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNA 362
Query: 410 -----LAHGDRWREDDCTFCQCVNGERHCVATVCG--QTCTNPVKVPGECCPVCE----E 458
+ G++W + C C+C + C C T ++V G+CCP C
Sbjct: 363 SEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCH 422
Query: 459 PTIITV--DPPACGELSNCT--LTGKDCIN----GFKRDHNGCRTCQ-----------CI 499
P +T P C + T L C++ GF + + C CQ C
Sbjct: 423 PDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLECS 482
Query: 500 NTEELCSERKQGCTLNCPFGFLTDAQNCEICE----------------CRPRPKKCRPII 543
+ + R C C GF D +C +C CR R
Sbjct: 483 SCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGG 542
Query: 544 CDKYCPLGLLKNKHGCDIC------------RCKKCPELS------CSKICPLGFQQDSH 585
C+ C G + C C RC C E + C CP G+ D+
Sbjct: 543 CESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADAT 602
Query: 586 G-CLICKCREASASAGPP-----------ILSGTCLTVDGHHHKNEESWHDGCRECYCLN 633
G C +C AS S P + G CL G ++ H C+ C+
Sbjct: 603 GRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSD---HGVCKACH--- 656
Query: 634 GREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVEGET- 692
+ + C PA P C + +Q +LS I P GE +
Sbjct: 657 ----SSCLACMGPA-------PSHCTGCKKPEEGLQVEQLSDVGI---PSGECLAQCRAH 702
Query: 693 WNIDSCTQC-TCHSGRVLCETEVCPPLLCQNPSRT--QDSCCPQCTDQPFRPSLSRNNSV 749
+ ++S C CH C + PS C QC D F S
Sbjct: 703 FYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECH 762
Query: 750 PNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLR-KGQC---- 804
P C+ G + + CI IS + +C + E L G C
Sbjct: 763 PT-CRQCHGPLE-----------SDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCH 810
Query: 805 --CPYCIEDTIPKKVVC 819
C +C D +C
Sbjct: 811 HLCQHCAADLHNTGSIC 827
>gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]
Length = 763
Score = 140 bits (354), Expect = 5e-33
Identities = 136/546 (24%), Positives = 203/546 (37%), Gaps = 95/546 (17%)
Query: 336 CVFNNVEYYDGDMF-RMDNCRFCRCQGGVAICFTAQCGEINCERYYVP---EGECCPVCE 391
C + + Y D D + D+CR C C+ G C C +NC +P G+CC VC
Sbjct: 273 CQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCR 332
Query: 392 DPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQ---CVNGERHCVATVCGQTCTNPVKV 448
C G +LA G R C C+ V C C + + +
Sbjct: 333 PK---------CIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEK--DHILP 381
Query: 449 PGECCPVCEEPTIITVDPPACGELSNC----TLTGKDCINGFKRDHNGCRTCQCINTEEL 504
+CC VC + P CGE S C T +C +G+ C+ I+
Sbjct: 382 ENQCCRVCRGHNFCA-EGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDE--- 437
Query: 505 CSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCD---I 561
C+ + C N + C+C P + C ++ G +H CD I
Sbjct: 438 CAAKMHYCHANT---VCVNLPGLYRCDCVPGYIRVDDFSCTEHDECG--SGQHNCDENAI 492
Query: 562 CRCKKCPELSCSKICPLGFQQDSHGCLICK--CREASASAGPPILSGTCLTVDGHHHKNE 619
C SC+ C G+ + IC+ C E G + C+ G +
Sbjct: 493 CT-NTVQGHSCT--CKPGYVGNG---TICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHC 546
Query: 620 ESWHDGC--RECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPS 677
E D C R C N C A G + P PSC+ D
Sbjct: 547 EKDIDECALRTHTCWNDS------ACINLAGGFDCLCPSG--PSCSGD------------ 586
Query: 678 ICHAPGGEYFVEGETWNI--DSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCT 735
C GG G+ W + D C+ C+C G++ C C CQNPS CCP+C
Sbjct: 587 -CPHEGGLKH-NGQVWTLKEDRCSVCSCKDGKIFCRRTACD---CQNPSADL-FCCPEC- 639
Query: 736 DQPFRPSLSRNNSVPNYCKNDEGD-IFLAAESWKPDVCTSCICIDSVISCFSESCPSVSC 794
+ V + C + G ++ + ++W C C C++ + C+ +CP++SC
Sbjct: 640 ----------DTRVTSQCLDQNGHKLYRSGDNWTHS-CQQCRCLEGEVDCWPLTCPNLSC 688
Query: 795 ERPVLRKGQCCPYCIED-------TIPKKVVCHFS-GKAYADEERWDL--DSCTHCYCLQ 844
E + +G+CCP C+ D T + C S G + W + CT C C
Sbjct: 689 EYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKN 748
Query: 845 GQTLCS 850
G+ CS
Sbjct: 749 GRVCCS 754
Score = 117 bits (294), Expect = 4e-26
Identities = 136/560 (24%), Positives = 193/560 (34%), Gaps = 140/560 (25%)
Query: 220 KVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRL 279
K CQ L + + S G+ C CK V+CR + CPP+ C PDS +
Sbjct: 271 KTCQVSGL-LYRDQDSWVDGDHCRNCTCKSG-AVECRRMSCPPLN---CSPDSLPVHIA- 324
Query: 280 TADGCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFN 339
G+CC V +P C++
Sbjct: 325 ----------------------------------------GQCCKV------CRPKCIYG 338
Query: 340 NVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCER--YYVPEGECCPVCEDPVY-- 395
+G +CR CR GGV + T C +NC + +PE +CC VC +
Sbjct: 339 GKVLAEGQRILTKSCRECR--GGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCA 396
Query: 396 ------------PFNNPAGCYA-NGLILAHGDRWREDDCTFCQCVNGERHCVA-TVCGQT 441
+N A C +G I GD +D +C +C A TVC
Sbjct: 397 EGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDID--ECAAKMHYCHANTVC--- 451
Query: 442 CTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCI-NGFKRDHNGCRTCQC-- 498
V +PG C P I VD +C E C +C N + +C C
Sbjct: 452 ----VNLPGLYRCDCV-PGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKP 506
Query: 499 --INTEELCSER-KQGCTLN----------CPFGFLTDAQNCEICECRPRPKKCRPIICD 545
+ +C ++GC CP GF +I EC R C D
Sbjct: 507 GYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCWN---D 563
Query: 546 KYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHG---------CLICKCRE-- 594
C N G C C P SCS CP +G C +C C++
Sbjct: 564 SACI-----NLAGGFDCLCPSGP--SCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGK 616
Query: 595 ------ASASAGPPI-----------LSGTCLTVDGHH-HKNEESWHDGCRECYCLNGRE 636
A P ++ CL +GH +++ ++W C++C CL G
Sbjct: 617 IFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEV 676
Query: 637 MCALITCPVPACGNPTIHPGQCCPSC-ADDFVVQKPELSTPSICHAPGGEYFVEGETWNI 695
C +TCP +C I G+CCP C +D + C G + G W +
Sbjct: 677 DCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTM 736
Query: 696 --DSCTQCTCHSGRVLCETE 713
CT C C +GRV C +
Sbjct: 737 AGSPCTTCKCKNGRVCCSVD 756
Score = 62.8 bits (151), Expect = 2e-09
Identities = 41/122 (33%), Positives = 55/122 (45%), Gaps = 15/122 (12%)
Query: 758 GDIFLAAESWKP-DVCTSCICIDSVISCFSESCPSVSCER---PVLRKGQCCPYCIEDTI 813
G ++ +SW D C +C C + C SCP ++C PV GQCC C
Sbjct: 277 GLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCR---- 332
Query: 814 PKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINV--EGSCCP 871
PK C + GK A+ +R SC C G + T CPPL C E ++ E CC
Sbjct: 333 PK---CIYGGKVLAEGQRILTKSCRECR--GGVLVKITEMCPPLNCSEKDHILPENQCCR 387
Query: 872 MC 873
+C
Sbjct: 388 VC 389
Score = 60.8 bits (146), Expect = 6e-09
Identities = 65/251 (25%), Positives = 92/251 (36%), Gaps = 41/251 (16%)
Query: 201 GECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYEC-KPVFGVDCRTVE 259
G C P++CVC P+G C+ + + + + C + C G DC
Sbjct: 526 GGTCVAPNKCVC-PSGFTGSHCEKD-----IDECALRTHTCWNDSACINLAGGFDCL--- 576
Query: 260 CP--PVQQTACPPD---SYETQVRLTADGCCTLPTRCECLSG--LCGFPVCEVGSTPRIV 312
CP P CP + + QV + C++ C C G C C+
Sbjct: 577 CPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSV---CSCKDGKIFCRRTACD-------- 625
Query: 313 SRGDGTPGKCCDVFECVNDTKPACVFNNVE--YYDGDMFRMDNCRFCRCQGGVAICFTAQ 370
+ CC EC C+ N Y GD + +C+ CRC G C+
Sbjct: 626 CQNPSADLFCCP--ECDTRVTSQCLDQNGHKLYRSGDNW-THSCQQCRCLEGEVDCWPLT 682
Query: 371 CGEINCERYYVPEGECCPVC-EDPVYPFN-----NPAGCYANGLILAHGDRW--REDDCT 422
C ++CE + EGECCP C DP N + G+ G W CT
Sbjct: 683 CPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCT 742
Query: 423 FCQCVNGERHC 433
C+C NG C
Sbjct: 743 TCKCKNGRVCC 753
Score = 57.0 bits (136), Expect = 9e-08
Identities = 24/59 (40%), Positives = 32/59 (54%), Gaps = 4/59 (6%)
Query: 819 CHFSGKAYADEERW-DLDSCTHCYCLQGQTLCSTVSCPPLPCVE---PINVEGSCCPMC 873
C SG Y D++ W D D C +C C G C +SCPPL C P+++ G CC +C
Sbjct: 273 CQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVC 331
>gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens]
Length = 955
Score = 135 bits (341), Expect = 2e-31
Identities = 106/386 (27%), Positives = 148/386 (38%), Gaps = 74/386 (19%)
Query: 527 CEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLG---FQQD 583
C C C C + C+ C + GC C C S + F
Sbjct: 404 CSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGC----CPSCTGCFHSGVVRAEGDVFSPP 459
Query: 584 SHGCLICKCREASASA-GPPILSG-----------TCLTVDGHHHKNEESWH-------- 623
+ C +C C + S P SG TC+ V + H W+
Sbjct: 460 NENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGR---WYADGAVFSG 516
Query: 624 --DGCRECYCLNGREMCALITCPVPACGNPT--IHPGQCCPSCADDFVVQKPELSTPSIC 679
D C C C NG C+ + CP AC + PGQCC +C Q+P ST
Sbjct: 517 GGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC------QEPTPSTGCSL 570
Query: 680 HAPGGEYFVEGETWNI-DSCTQCTCHS-GRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQ 737
G E+ + G+ W+ D C C C + G V C+ C C +P R CCP C+
Sbjct: 571 DDNGVEFPI-GQIWSPGDPCELCICQADGSVSCKRTDCVDS-CPHPIRIPGQCCPDCSAG 628
Query: 738 PFRPSLSRNNSVPNYCKNDEGDIFLAAESWKP--DVCTSCICIDSVISCFSESCPSVSCE 795
C G IF E++ D C SCIC+ ++C CP ++C
Sbjct: 629 ---------------CTYT-GRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCP-ITCT 671
Query: 796 RPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDS--CTHCYCLQGQTLCSTVS 853
P G+CCP C + C++ G+ A+ + + LD CT C C G+ C V
Sbjct: 672 YPFHPDGECCPVCRD--------CNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVP 723
Query: 854 CPPLPCVEPINVEGSCCPMCPEMYVP 879
C C +P + G CC CP+ P
Sbjct: 724 CQRA-CADPALLPGDCCSSCPDSLSP 748
Score = 126 bits (317), Expect = 9e-29
Identities = 91/314 (28%), Positives = 124/314 (39%), Gaps = 72/314 (22%)
Query: 613 GHHHKNEESWHD-GCRECYCLNGREMCALITCPVPACGNPT-IHPGQCCPSCADDF---- 666
G H++ W + GC +C+C +G+ C + C AC +P G CCPSC F
Sbjct: 390 GAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEA-ACSHPIPSRDGGCCPSCTGCFHSGV 448
Query: 667 ------VVQKP-ELSTPSICHAPG--------------------------------GEYF 687
V P E T +C A G ++
Sbjct: 449 VRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWY 508
Query: 688 VEGETWNI--DSCTQCTCHSGRVLCETEVCPPLLCQNPSRT--QDSCCPQCTDQPFRPSL 743
+G ++ D CT C C +G V C CP L C CC C + P+
Sbjct: 509 ADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQE----PTP 564
Query: 744 SRNNSVPNYCKNDEGDIFLAAESWKP-DVCTSCIC-IDSVISCFSESCPSVSCERPVLRK 801
S S+ +D G F + W P D C CIC D +SC C SC P+
Sbjct: 565 STGCSL-----DDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCVD-SCPHPIRIP 618
Query: 802 GQCCPYCIEDTIPKKVVCHFSGKAYADEERWD--LDSCTHCYCLQGQTLCSTVSCPPLPC 859
GQCCP C C ++G+ + + E + LD C C CL G CS V C P+ C
Sbjct: 619 GQCCPDC-------SAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDC-PITC 670
Query: 860 VEPINVEGSCCPMC 873
P + +G CCP+C
Sbjct: 671 TYPFHPDGECCPVC 684
Score = 117 bits (294), Expect = 4e-26
Identities = 109/434 (25%), Positives = 149/434 (34%), Gaps = 87/434 (20%)
Query: 400 PAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPV-KVPGECCPVCEE 458
P+ C+ G + RW E C+ C C +G+ C C C++P+ G CCP C
Sbjct: 383 PSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGCCPSC-- 440
Query: 459 PTIITVDPPACGELSNCTLTGKDCING--FKRDHNGCRTCQCINTEELCSERKQGCTLNC 516
+ C +G G F + C C C+ C + C
Sbjct: 441 --------------TGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSC------ISPEC 480
Query: 517 PFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHG--CDICRCKK-------- 566
P G + C C P R ++ G + + G C C C+
Sbjct: 481 PSGPCQTPPQTDCCTCVP----VRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFM 536
Query: 567 -CPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDG 625
CPEL+ CP + G C+E + S +G L +G + W G
Sbjct: 537 PCPELA----CPREEWRLGPGQCCFTCQEPTPS------TGCSLDDNGVEFPIGQIWSPG 586
Query: 626 --CRECYC-LNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAP 682
C C C +G C C V +C +P PGQCCP C+
Sbjct: 587 DPCELCICQADGSVSCKRTDC-VDSCPHPIRIPGQCCPDCSAGCTYT------------- 632
Query: 683 GGEYFVEGETWN--IDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFR 740
G F ET+ +D C C C G V C C P+ C P CCP C D +
Sbjct: 633 -GRIFYNNETFPSVLDPCLSCICLLGSVACSPVDC-PITCTYPFHPDGECCPVCRDCNYE 690
Query: 741 PSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLR 800
N V + +DE CT C C +SC C +C P L
Sbjct: 691 GRKVANGQV--FTLDDE-------------PCTRCTCQLGEVSCEKVPCQR-ACADPALL 734
Query: 801 KGQCCPYCIEDTIP 814
G CC C + P
Sbjct: 735 PGDCCSSCPDSLSP 748
Score = 101 bits (251), Expect = 4e-21
Identities = 94/365 (25%), Positives = 129/365 (35%), Gaps = 104/365 (28%)
Query: 168 EEEKPDCSKARCEVQFSPRCPEDSVLIEGYAPPGECCPLPSRC-----------VCNPAG 216
E+ K C K RCE S P G CCP + C V +P
Sbjct: 410 EDGKVTCEKVRCEAACSHPIPSRD---------GGCCPSCTGCFHSGVVRAEGDVFSPPN 460
Query: 217 --CLRKVCQPGNLNILVSKASGKP------GECCDLYECKPVF--------------GVD 254
C VC GN++ + + P +CC + F G +
Sbjct: 461 ENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDE 520
Query: 255 CRT-------VECP--PVQQTACPPDSYETQVRLTADGCC------TLPTRCECLSGLCG 299
C T VEC P + ACP + + RL CC T T C
Sbjct: 521 CTTCVCQNGEVECSFMPCPELACPREEW----RLGPGQCCFTCQEPTPSTGCSLDDNGVE 576
Query: 300 FPVCEVGST----PRIVSRGDGT------------------PGKCCDVFECVNDTKPACV 337
FP+ ++ S + + DG+ PG+CC D C
Sbjct: 577 FPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCP------DCSAGCT 630
Query: 338 FNNVEYYDGDMFR--MDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVY 395
+ +Y+ + F +D C C C G C C I C + P+GECCPVC D
Sbjct: 631 YTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDC-PITCTYPFHPDGECCPVCRD--- 686
Query: 396 PFNNPAGCYANGLILAHGDRWREDD--CTFCQCVNGERHCVATVCGQTCTNPVKVPGECC 453
C G +A+G + DD CT C C GE C C + C +P +PG+CC
Sbjct: 687 -------CNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLPGDCC 739
Query: 454 PVCEE 458
C +
Sbjct: 740 SSCPD 744
Score = 63.2 bits (152), Expect = 1e-09
Identities = 83/353 (23%), Positives = 119/353 (33%), Gaps = 75/353 (21%)
Query: 122 FKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKR--------------I 167
F P NEN C + G C + S P + P Q C + +
Sbjct: 456 FSPPNENCTV-CVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVF 514
Query: 168 EEEKPDCSKARC-----EVQFSPRCPEDSVLIEGYA-PPGECC-----PLPSR-CVCNPA 215
+C+ C E F P CPE + E + PG+CC P PS C +
Sbjct: 515 SGGGDECTTCVCQNGEVECSFMP-CPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDN 573
Query: 216 GCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACP-PDSYE 274
G + Q + PG+ C+L C+ V C+ +C +CP P
Sbjct: 574 GVEFPIGQIWS-----------PGDPCELCICQADGSVSCKRTDCVD----SCPHPIRIP 618
Query: 275 TQVRLTADGCCTLPTRC------------ECLSGLC--GFPVCEVGSTPRIVSRGDGTPG 320
Q CT R CLS +C G C P + G
Sbjct: 619 GQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDG 678
Query: 321 KCCDVFECVNDTKPACVFNNVEYYDGDMFRMDN--CRFCRCQGGVAICFTAQCGEINCER 378
+CC V C + + +G +F +D+ C C CQ G C C +
Sbjct: 679 ECCPVCR-------DCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADP 731
Query: 379 YYVPEGECCPVCEDPVYPFNNPAGCYANGLIL-------AHGDRWREDDCTFC 424
+P G+CC C D + P G +G + HGD +C+ C
Sbjct: 732 ALLP-GDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSC 783
Score = 47.0 bits (110), Expect = 9e-05
Identities = 26/91 (28%), Positives = 36/91 (39%), Gaps = 15/91 (16%)
Query: 819 CHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPI-NVEGSCCPMCPEMY 877
C G + RW C+ C+C G+ C V C C PI + +G CCP C +
Sbjct: 386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRC-EAACSHPIPSRDGGCCPSCTGCF 444
Query: 878 VPEPTNIPIEKTNHRGEVDLEVPLWPTPSEN 908
H G V E ++ P+EN
Sbjct: 445 -------------HSGVVRAEGDVFSPPNEN 462
>gi|37693519 BMP-binding endothelial regulator precursor protein
[Homo sapiens]
Length = 685
Score = 135 bits (340), Expect = 2e-31
Identities = 110/383 (28%), Positives = 157/383 (40%), Gaps = 73/383 (19%)
Query: 514 LNC---PFGFLTDAQNCEICECRPRPKKCR-PIICDKYCPLGLLKNKHGCDICRCKKCPE 569
LNC P + + +C + + P I D C + + NK C+ +KCP
Sbjct: 29 LNCSGVPMSLASSFLTGSVAKCENEGEVLQIPFITDNPCIMCVCLNKEVT--CKREKCPV 86
Query: 570 LSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCREC 629
LS + C L +Q C CK T +G+ + + W C
Sbjct: 87 LS--RDCALAIKQRGACCEQCKG----------------CTYEGNTYNSSFKWQSPAEPC 128
Query: 630 Y---CLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEY 686
C G + + C V C NP H G CCP+C P + + G E+
Sbjct: 129 VLRQCQEGVVTESGVRCVVH-CKNPLEHLGMCCPTC--------PGCVFEGVQYQEGEEF 179
Query: 687 FVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLC-QNPSRTQDS-CCPQCTDQ------P 738
EG CT+C+C GR C EVCP L C Q+ S CCP+C Q P
Sbjct: 180 QPEGS-----KCTKCSCTGGRTQCVREVCPILSCPQHLSHIPPGQCCPKCLGQRKVFDLP 234
Query: 739 FRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPV 798
F L R+ D++ S+ D CT+C C DS + C + C++
Sbjct: 235 FGSCLFRS------------DVYDNGSSFLYDNCTACTCRDSTVVCKRKCSHPGGCDQ-- 280
Query: 799 LRKGQ--CCPYCIEDTIPKKV-VCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCP 855
GQ CC C+ P+ + VC F K + D E W +CT C C++G+T C C
Sbjct: 281 ---GQEGCCEECLLRVPPEDIKVCKFGNKIFQDGEMWSSINCTICACVKGRTECRNKQCI 337
Query: 856 PL---PCVEPINVEGSCCPMCPE 875
P+ P + +N +G CCP+C E
Sbjct: 338 PISSCPQGKILNRKG-CCPICTE 359
Score = 85.5 bits (210), Expect = 2e-16
Identities = 60/224 (26%), Positives = 94/224 (41%), Gaps = 28/224 (12%)
Query: 320 GKCCDVFECVNDTKPACVFNNVEYYDGDMFRMD--NCRFCRCQGGVAICFTAQCGEINCE 377
G CC T P CVF V+Y +G+ F+ + C C C GG C C ++C
Sbjct: 157 GMCCP-------TCPGCVFEGVQYQEGEEFQPEGSKCTKCSCTGGRTQCVREVCPILSCP 209
Query: 378 RY--YVPEGECCPVCEDPVYPFNNPAG-CYANGLILAHGDRWREDDCTFCQCVNGERHCV 434
++ ++P G+CCP C F+ P G C + +G + D+CT C C +
Sbjct: 210 QHLSHIPPGQCCPKCLGQRKVFDLPFGSCLFRSDVYDNGSSFLYDNCTACTCRDS----- 264
Query: 435 ATVCGQTCTNPVKVPGEC---CPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHN 491
VC + C++ PG C C E ++ V P ++ C K +G
Sbjct: 265 TVVCKRKCSH----PGGCDQGQEGCCEECLLRVPPE---DIKVCKFGNKIFQDGEMWSSI 317
Query: 492 GCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQN-CEICECRP 534
C C C+ C ++ +CP G + + + C IC +P
Sbjct: 318 NCTICACVKGRTECRNKQCIPISSCPQGKILNRKGCCPICTEKP 361
Score = 78.6 bits (192), Expect = 3e-14
Identities = 74/314 (23%), Positives = 110/314 (35%), Gaps = 90/314 (28%)
Query: 510 QGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIIC---DKYCPLGLLKNKHGCDICRCKK 566
+G L PF +TD C +C C + C+ C + C L + + C+ +CK
Sbjct: 53 EGEVLQIPF--ITD-NPCIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGACCE--QCKG 107
Query: 567 CPELSCSKICPLGFQQDSHGCLICKCREASASAGP---------PI--LSGTCLTVDG-- 613
C + +Q + C++ +C+E + P+ L C T G
Sbjct: 108 CTYEGNTYNSSFKWQSPAEPCVLRQCQEGVVTESGVRCVVHCKNPLEHLGMCCPTCPGCV 167
Query: 614 ----HHHKNEESWHDG--CRECYCLNGREMCALITCPVPACGNPTIH--PGQCCP----- 660
+ + EE +G C +C C GR C CP+ +C H PGQCCP
Sbjct: 168 FEGVQYQEGEEFQPEGSKCTKCSCTGGRTQCVREVCPILSCPQHLSHIPPGQCCPKCLGQ 227
Query: 661 --------------------------------SCADDFVVQKPELSTPSICHAP------ 682
+C D VV K + S P C
Sbjct: 228 RKVFDLPFGSCLFRSDVYDNGSSFLYDNCTACTCRDSTVVCKRKCSHPGGCDQGQEGCCE 287
Query: 683 ----------------GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLC--QNPS 724
G + F +GE W+ +CT C C GR C + C P+ Q
Sbjct: 288 ECLLRVPPEDIKVCKFGNKIFQDGEMWSSINCTICACVKGRTECRNKQCIPISSCPQGKI 347
Query: 725 RTQDSCCPQCTDQP 738
+ CCP CT++P
Sbjct: 348 LNRKGCCPICTEKP 361
Score = 78.6 bits (192), Expect = 3e-14
Identities = 66/231 (28%), Positives = 93/231 (40%), Gaps = 34/231 (14%)
Query: 289 TRCECLSGL--CGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKP------ACVFNN 340
T+C C G C VC + S P+ +S PG+CC +C+ K +C+F +
Sbjct: 187 TKCSCTGGRTQCVREVCPILSCPQHLSHIP--PGQCCP--KCLGQRKVFDLPFGSCLFRS 242
Query: 341 VEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNP 400
Y +G F DNC C C+ +C C++ EG CC C V P +
Sbjct: 243 DVYDNGSSFLYDNCTACTCRDSTVVCKRKCSHPGGCDQGQ--EG-CCEECLLRVPPEDIK 299
Query: 401 AGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNP---VKVPGECCPVC- 456
C I G+ W +CT C CV G C C + P + CCP+C
Sbjct: 300 V-CKFGNKIFQDGEMWSSINCTICACVKGRTECRNKQCIPISSCPQGKILNRKGCCPICT 358
Query: 457 EEPTIITVDPPACGELSNCTLTGKDCINGFK-RDHNGCRTCQCINTEELCS 506
E+P + CT+ G N F R N TCQ + T++ S
Sbjct: 359 EKPGV-------------CTVFGDPHYNTFDGRTFNFQGTCQYVLTKDCSS 396
Score = 66.2 bits (160), Expect = 1e-10
Identities = 88/376 (23%), Positives = 120/376 (31%), Gaps = 73/376 (19%)
Query: 349 FRMDN-CRFCRCQGGVAICFTAQCGEIN--CERYYVPEGECCPVCEDPVYPFNNPAGCYA 405
F DN C C C C +C ++ C G CC C+ GC
Sbjct: 61 FITDNPCIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGACCEQCK----------GCTY 110
Query: 406 NGLILAHGDRWRE--DDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIIT 463
G +W+ + C QC G C C NP++ G CCP C
Sbjct: 111 EGNTYNSSFKWQSPAEPCVLRQCQEGVVTESGVRCVVHCKNPLEHLGMCCPTC------- 163
Query: 464 VDPPACGELSNCTLTGKDCING--FKRDHNGCRTCQCINTEELCSERKQGCTLNCP--FG 519
C G G F+ + + C C C C R+ L+CP
Sbjct: 164 ---------PGCVFEGVQYQEGEEFQPEGSKCTKCSCTGGRTQC-VREVCPILSCPQHLS 213
Query: 520 FLTDAQNCEICECRPR----PKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKI 575
+ Q C C + + P D Y G C C C+ + C +
Sbjct: 214 HIPPGQCCPKCLGQRKVFDLPFGSCLFRSDVY-DNGSSFLYDNCTACTCRD-STVVCKRK 271
Query: 576 C--PLGFQQDSHGCLICKCREASASAGPPILS----GTCLTVDGHHHKNEESWHD-GCRE 628
C P G Q GC C E P + G + DG E W C
Sbjct: 272 CSHPGGCDQGQEGC----CEECLLRVPPEDIKVCKFGNKIFQDG------EMWSSINCTI 321
Query: 629 CYCLNGREMCALITC-PVPACGNPTI-HPGQCCPSCADDFVVQKPELSTPSICHAPGGEY 686
C C+ GR C C P+ +C I + CCP C + P +C G +
Sbjct: 322 CACVKGRTECRNKQCIPISSCPQGKILNRKGCCPICTE----------KPGVCTVFGDPH 371
Query: 687 F--VEGETWNIDSCTQ 700
+ +G T+N Q
Sbjct: 372 YNTFDGRTFNFQGTCQ 387
Score = 52.4 bits (124), Expect = 2e-06
Identities = 57/214 (26%), Positives = 79/214 (36%), Gaps = 47/214 (21%)
Query: 195 EGYAPPGECCPLPSRCVCNPAGCLRKVCQ----PGNLNILVSKASGKPGECCDLYECKPV 250
E + P G C S C C+R+VC P +L+ + PG+CC +C
Sbjct: 177 EEFQPEGSKCTKCS-CTGGRTQCVREVCPILSCPQHLSHI------PPGQCCP--KC--- 224
Query: 251 FGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSG--LCGFPVCEVGST 308
+ R V P D Y+ D C T C C +C G
Sbjct: 225 --LGQRKVFDLPFGSCLFRSDVYDNGSSFLYDNC----TACTCRDSTVVCKRKCSHPGGC 278
Query: 309 PRIVSRGDGTPGKCCDVFECVNDTKP----ACVFNNVEYYDGDMFRMDNCRFCRCQGGVA 364
+ G G CC+ EC+ P C F N + DG+M+ NC C C G
Sbjct: 279 DQ------GQEG-CCE--ECLLRVPPEDIKVCKFGNKIFQDGEMWSSINCTICACVKGRT 329
Query: 365 ICFTAQCGEINCERYYVPEGE------CCPVCED 392
C QC I+ P+G+ CCP+C +
Sbjct: 330 ECRNKQCIPISS----CPQGKILNRKGCCPICTE 359
>gi|223029476 NEL-like protein 2 isoform d [Homo sapiens]
Length = 839
Score = 115 bits (288), Expect = 2e-25
Identities = 144/625 (23%), Positives = 217/625 (34%), Gaps = 162/625 (25%)
Query: 282 DGCCTLPTRCECLSG-------LCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKP 334
DGC C CL+G +C P C + S V GKCC EC K
Sbjct: 312 DGC----KNCTCLNGTIQCETLICPNPDCPLKSALAYVD------GKCCK--EC----KS 355
Query: 335 ACVFNNVEYYDGDMFRMDN----CRFCRCQGG-VAICFTAQCGEINCERYY--VPEGECC 387
C F Y++G+ + + C C+ + + ++ C ++C + CC
Sbjct: 356 ICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCC 415
Query: 388 PVCEDPVYPF-NNPAGCYANGLILAHGDR-----------WREDDCTFCQ----CVNGER 431
VC+ Y F + C N + DR RED+ +C+ C G
Sbjct: 416 KVCKG--YDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNA-YCEDIDECAEGRH 472
Query: 432 HCVA-TVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDH 490
+C T+C V PG +C+ I +D +C E C +C D
Sbjct: 473 YCRENTMC-------VNTPGSFMCICKTG-YIRIDDYSCTEHDECITNQHNC------DE 518
Query: 491 NGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPL 550
N LC G C G+ + C+ C C
Sbjct: 519 NA-----------LCFNTVGGHNCVCKPGYTGNGTTCKA-------------FCKDGC-- 552
Query: 551 GLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLT 610
+N C CP+ C + S G + C R C+
Sbjct: 553 ---RNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSR------------ANCIN 597
Query: 611 VDGHHHKNEESWHDGCRECYCLNGREMCALITCP-VPACGNPTIHPGQCCPSCADDFVVQ 669
+ G +H CR+ Y NG + +C + CG SCA+D +
Sbjct: 598 LPGWYHCE-------CRDGYHDNGMFSPSGESCEDIDECGTGR-------HSCANDTICF 643
Query: 670 KPELSTPSICHAPGGEYFV-----------EGETWNI--DSCTQCTCHSGRVLCETEVCP 716
L C P G+ G+ W + D C+ C+C +G V+C VC
Sbjct: 644 N--LDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCD 701
Query: 717 PLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGD-IFLAAESWKPDVCTSC 775
C+NP+ CCP+C P LS + C + G+ ++ + ++W + C C
Sbjct: 702 ---CENPT-VDLFCCPECD-----PRLS------SQCLHQNGETLYNSGDTWVQN-CQQC 745
Query: 776 ICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADE------ 829
C+ + C+ CP V CE +L + +CCP C+ D + + K DE
Sbjct: 746 RCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRF 805
Query: 830 --ERW--DLDSCTHCYCLQGQTLCS 850
W CT C C G CS
Sbjct: 806 TGSSWIKHGTECTLCQCKNGHICCS 830
Score = 82.0 bits (201), Expect = 3e-15
Identities = 122/524 (23%), Positives = 184/524 (35%), Gaps = 89/524 (16%)
Query: 403 CYANGLILAHGDRWRE-----DDCTFCQCVNGERHCVATVC-GQTCTNPVK-----VPGE 451
CY G +RE D C C C+NG C +C C P+K V G+
Sbjct: 291 CYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDC--PLKSALAYVDGK 348
Query: 452 CCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDH-------NGCRTCQCINTEEL 504
CC C+ GE + + C+ +D +GC C + ++
Sbjct: 349 CCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQI 408
Query: 505 CSERKQGCTLNCPFGFLTDAQNC------------EICECRPRPKKCRPIICDKYCPLGL 552
C + + F ++ NC +C CR + R + YC +
Sbjct: 409 TLSHSC-CKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALRED--NAYCE-DI 464
Query: 553 LKNKHGCDICR----CKKCPELSCSKICPLGFQQ-DSHGCLICKCREASASAGPPILSGT 607
+ G CR C P S IC G+ + D + C + E + +
Sbjct: 465 DECAEGRHYCRENTMCVNTPG-SFMCICKTGYIRIDDYSCT--EHDECITNQHNCDENAL 521
Query: 608 CL-TVDGHHHKNEESWHDGCREC--YCLNG-REMCALITCPVPACGNPTIHPGQCCPS-- 661
C TV GH+ + + C +C +G R A I V AC P G C +
Sbjct: 522 CFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCAC--PQGFTGPSCETDI 579
Query: 662 --CADDFVVQKPE---LSTPSICHAPGGEYFVEGETWNI--DSCTQCT-CHSGRVLCETE 713
C+D FV ++ P H + + + ++ +SC C +GR C +
Sbjct: 580 DECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAND 639
Query: 714 VCPPLLCQNPSRTQDSCCPQ---CTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPD 770
+C N D CP CT ++N +ND
Sbjct: 640 T----ICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDR------------- 682
Query: 771 VCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKA-YADE 829
C+ C C + + C C CE P + CCP C D H +G+ Y
Sbjct: 683 -CSVCSCQNGFVMCRRMVC---DCENPTVDLF-CCPEC--DPRLSSQCLHQNGETLYNSG 735
Query: 830 ERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMC 873
+ W + +C C CLQG+ C + CP + C I E CCP C
Sbjct: 736 DTW-VQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRC 778
>gi|223029474 NEL-like protein 2 isoform c [Homo sapiens]
Length = 815
Score = 115 bits (288), Expect = 2e-25
Identities = 144/625 (23%), Positives = 217/625 (34%), Gaps = 162/625 (25%)
Query: 282 DGCCTLPTRCECLSG-------LCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKP 334
DGC C CL+G +C P C + S V GKCC EC K
Sbjct: 288 DGC----KNCTCLNGTIQCETLICPNPDCPLKSALAYVD------GKCCK--EC----KS 331
Query: 335 ACVFNNVEYYDGDMFRMDN----CRFCRCQGG-VAICFTAQCGEINCERYY--VPEGECC 387
C F Y++G+ + + C C+ + + ++ C ++C + CC
Sbjct: 332 ICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCC 391
Query: 388 PVCEDPVYPF-NNPAGCYANGLILAHGDR-----------WREDDCTFCQ----CVNGER 431
VC+ Y F + C N + DR RED+ +C+ C G
Sbjct: 392 KVCKG--YDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNA-YCEDIDECAEGRH 448
Query: 432 HCVA-TVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDH 490
+C T+C V PG +C+ I +D +C E C +C D
Sbjct: 449 YCRENTMC-------VNTPGSFMCICKTG-YIRIDDYSCTEHDECITNQHNC------DE 494
Query: 491 NGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPL 550
N LC G C G+ + C+ C C
Sbjct: 495 NA-----------LCFNTVGGHNCVCKPGYTGNGTTCKA-------------FCKDGC-- 528
Query: 551 GLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLT 610
+N C CP+ C + S G + C R C+
Sbjct: 529 ---RNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSR------------ANCIN 573
Query: 611 VDGHHHKNEESWHDGCRECYCLNGREMCALITCP-VPACGNPTIHPGQCCPSCADDFVVQ 669
+ G +H CR+ Y NG + +C + CG SCA+D +
Sbjct: 574 LPGWYHCE-------CRDGYHDNGMFSPSGESCEDIDECGTGR-------HSCANDTICF 619
Query: 670 KPELSTPSICHAPGGEYFV-----------EGETWNI--DSCTQCTCHSGRVLCETEVCP 716
L C P G+ G+ W + D C+ C+C +G V+C VC
Sbjct: 620 N--LDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCD 677
Query: 717 PLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGD-IFLAAESWKPDVCTSC 775
C+NP+ CCP+C P LS + C + G+ ++ + ++W + C C
Sbjct: 678 ---CENPT-VDLFCCPECD-----PRLS------SQCLHQNGETLYNSGDTWVQN-CQQC 721
Query: 776 ICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADE------ 829
C+ + C+ CP V CE +L + +CCP C+ D + + K DE
Sbjct: 722 RCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRF 781
Query: 830 --ERW--DLDSCTHCYCLQGQTLCS 850
W CT C C G CS
Sbjct: 782 TGSSWIKHGTECTLCQCKNGHICCS 806
Score = 82.0 bits (201), Expect = 3e-15
Identities = 122/524 (23%), Positives = 184/524 (35%), Gaps = 89/524 (16%)
Query: 403 CYANGLILAHGDRWRE-----DDCTFCQCVNGERHCVATVC-GQTCTNPVK-----VPGE 451
CY G +RE D C C C+NG C +C C P+K V G+
Sbjct: 267 CYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDC--PLKSALAYVDGK 324
Query: 452 CCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDH-------NGCRTCQCINTEEL 504
CC C+ GE + + C+ +D +GC C + ++
Sbjct: 325 CCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQI 384
Query: 505 CSERKQGCTLNCPFGFLTDAQNC------------EICECRPRPKKCRPIICDKYCPLGL 552
C + + F ++ NC +C CR + R + YC +
Sbjct: 385 TLSHSC-CKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALRED--NAYCE-DI 440
Query: 553 LKNKHGCDICR----CKKCPELSCSKICPLGFQQ-DSHGCLICKCREASASAGPPILSGT 607
+ G CR C P S IC G+ + D + C + E + +
Sbjct: 441 DECAEGRHYCRENTMCVNTPG-SFMCICKTGYIRIDDYSCT--EHDECITNQHNCDENAL 497
Query: 608 CL-TVDGHHHKNEESWHDGCREC--YCLNG-REMCALITCPVPACGNPTIHPGQCCPS-- 661
C TV GH+ + + C +C +G R A I V AC P G C +
Sbjct: 498 CFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCAC--PQGFTGPSCETDI 555
Query: 662 --CADDFVVQKPE---LSTPSICHAPGGEYFVEGETWNI--DSCTQCT-CHSGRVLCETE 713
C+D FV ++ P H + + + ++ +SC C +GR C +
Sbjct: 556 DECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAND 615
Query: 714 VCPPLLCQNPSRTQDSCCPQ---CTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPD 770
+C N D CP CT ++N +ND
Sbjct: 616 T----ICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDR------------- 658
Query: 771 VCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKA-YADE 829
C+ C C + + C C CE P + CCP C D H +G+ Y
Sbjct: 659 -CSVCSCQNGFVMCRRMVC---DCENPTVDLF-CCPEC--DPRLSSQCLHQNGETLYNSG 711
Query: 830 ERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMC 873
+ W + +C C CLQG+ C + CP + C I E CCP C
Sbjct: 712 DTW-VQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRC 754
>gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens]
Length = 816
Score = 115 bits (288), Expect = 2e-25
Identities = 144/625 (23%), Positives = 217/625 (34%), Gaps = 162/625 (25%)
Query: 282 DGCCTLPTRCECLSG-------LCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKP 334
DGC C CL+G +C P C + S V GKCC EC K
Sbjct: 289 DGC----KNCTCLNGTIQCETLICPNPDCPLKSALAYVD------GKCCK--EC----KS 332
Query: 335 ACVFNNVEYYDGDMFRMDN----CRFCRCQGG-VAICFTAQCGEINCERYY--VPEGECC 387
C F Y++G+ + + C C+ + + ++ C ++C + CC
Sbjct: 333 ICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCC 392
Query: 388 PVCEDPVYPF-NNPAGCYANGLILAHGDR-----------WREDDCTFCQ----CVNGER 431
VC+ Y F + C N + DR RED+ +C+ C G
Sbjct: 393 KVCKG--YDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNA-YCEDIDECAEGRH 449
Query: 432 HCVA-TVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDH 490
+C T+C V PG +C+ I +D +C E C +C D
Sbjct: 450 YCRENTMC-------VNTPGSFMCICKTG-YIRIDDYSCTEHDECITNQHNC------DE 495
Query: 491 NGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPL 550
N LC G C G+ + C+ C C
Sbjct: 496 NA-----------LCFNTVGGHNCVCKPGYTGNGTTCKA-------------FCKDGC-- 529
Query: 551 GLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLT 610
+N C CP+ C + S G + C R C+
Sbjct: 530 ---RNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSR------------ANCIN 574
Query: 611 VDGHHHKNEESWHDGCRECYCLNGREMCALITCP-VPACGNPTIHPGQCCPSCADDFVVQ 669
+ G +H CR+ Y NG + +C + CG SCA+D +
Sbjct: 575 LPGWYHCE-------CRDGYHDNGMFSPSGESCEDIDECGTGR-------HSCANDTICF 620
Query: 670 KPELSTPSICHAPGGEYFV-----------EGETWNI--DSCTQCTCHSGRVLCETEVCP 716
L C P G+ G+ W + D C+ C+C +G V+C VC
Sbjct: 621 N--LDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCD 678
Query: 717 PLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGD-IFLAAESWKPDVCTSC 775
C+NP+ CCP+C P LS + C + G+ ++ + ++W + C C
Sbjct: 679 ---CENPT-VDLFCCPECD-----PRLS------SQCLHQNGETLYNSGDTWVQN-CQQC 722
Query: 776 ICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADE------ 829
C+ + C+ CP V CE +L + +CCP C+ D + + K DE
Sbjct: 723 RCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRF 782
Query: 830 --ERW--DLDSCTHCYCLQGQTLCS 850
W CT C C G CS
Sbjct: 783 TGSSWIKHGTECTLCQCKNGHICCS 807
Score = 82.0 bits (201), Expect = 3e-15
Identities = 122/524 (23%), Positives = 184/524 (35%), Gaps = 89/524 (16%)
Query: 403 CYANGLILAHGDRWRE-----DDCTFCQCVNGERHCVATVC-GQTCTNPVK-----VPGE 451
CY G +RE D C C C+NG C +C C P+K V G+
Sbjct: 268 CYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDC--PLKSALAYVDGK 325
Query: 452 CCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDH-------NGCRTCQCINTEEL 504
CC C+ GE + + C+ +D +GC C + ++
Sbjct: 326 CCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQI 385
Query: 505 CSERKQGCTLNCPFGFLTDAQNC------------EICECRPRPKKCRPIICDKYCPLGL 552
C + + F ++ NC +C CR + R + YC +
Sbjct: 386 TLSHSC-CKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALRED--NAYCE-DI 441
Query: 553 LKNKHGCDICR----CKKCPELSCSKICPLGFQQ-DSHGCLICKCREASASAGPPILSGT 607
+ G CR C P S IC G+ + D + C + E + +
Sbjct: 442 DECAEGRHYCRENTMCVNTPG-SFMCICKTGYIRIDDYSCT--EHDECITNQHNCDENAL 498
Query: 608 CL-TVDGHHHKNEESWHDGCREC--YCLNG-REMCALITCPVPACGNPTIHPGQCCPS-- 661
C TV GH+ + + C +C +G R A I V AC P G C +
Sbjct: 499 CFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCAC--PQGFTGPSCETDI 556
Query: 662 --CADDFVVQKPE---LSTPSICHAPGGEYFVEGETWNI--DSCTQCT-CHSGRVLCETE 713
C+D FV ++ P H + + + ++ +SC C +GR C +
Sbjct: 557 DECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAND 616
Query: 714 VCPPLLCQNPSRTQDSCCPQ---CTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPD 770
+C N D CP CT ++N +ND
Sbjct: 617 T----ICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDR------------- 659
Query: 771 VCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKA-YADE 829
C+ C C + + C C CE P + CCP C D H +G+ Y
Sbjct: 660 -CSVCSCQNGFVMCRRMVC---DCENPTVDLF-CCPEC--DPRLSSQCLHQNGETLYNSG 712
Query: 830 ERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMC 873
+ W + +C C CLQG+ C + CP + C I E CCP C
Sbjct: 713 DTW-VQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRC 755
>gi|223029470 NEL-like protein 2 isoform a [Homo sapiens]
Length = 866
Score = 115 bits (288), Expect = 2e-25
Identities = 144/625 (23%), Positives = 217/625 (34%), Gaps = 162/625 (25%)
Query: 282 DGCCTLPTRCECLSG-------LCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKP 334
DGC C CL+G +C P C + S V GKCC EC K
Sbjct: 339 DGC----KNCTCLNGTIQCETLICPNPDCPLKSALAYVD------GKCCK--EC----KS 382
Query: 335 ACVFNNVEYYDGDMFRMDN----CRFCRCQGG-VAICFTAQCGEINCERYY--VPEGECC 387
C F Y++G+ + + C C+ + + ++ C ++C + CC
Sbjct: 383 ICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCC 442
Query: 388 PVCEDPVYPF-NNPAGCYANGLILAHGDR-----------WREDDCTFCQ----CVNGER 431
VC+ Y F + C N + DR RED+ +C+ C G
Sbjct: 443 KVCKG--YDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNA-YCEDIDECAEGRH 499
Query: 432 HCVA-TVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDH 490
+C T+C V PG +C+ I +D +C E C +C D
Sbjct: 500 YCRENTMC-------VNTPGSFMCICKTG-YIRIDDYSCTEHDECITNQHNC------DE 545
Query: 491 NGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPL 550
N LC G C G+ + C+ C C
Sbjct: 546 NA-----------LCFNTVGGHNCVCKPGYTGNGTTCKA-------------FCKDGC-- 579
Query: 551 GLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLT 610
+N C CP+ C + S G + C R C+
Sbjct: 580 ---RNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSR------------ANCIN 624
Query: 611 VDGHHHKNEESWHDGCRECYCLNGREMCALITCP-VPACGNPTIHPGQCCPSCADDFVVQ 669
+ G +H CR+ Y NG + +C + CG SCA+D +
Sbjct: 625 LPGWYHCE-------CRDGYHDNGMFSPSGESCEDIDECGTGR-------HSCANDTICF 670
Query: 670 KPELSTPSICHAPGGEYFV-----------EGETWNI--DSCTQCTCHSGRVLCETEVCP 716
L C P G+ G+ W + D C+ C+C +G V+C VC
Sbjct: 671 N--LDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCD 728
Query: 717 PLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGD-IFLAAESWKPDVCTSC 775
C+NP+ CCP+C P LS + C + G+ ++ + ++W + C C
Sbjct: 729 ---CENPT-VDLFCCPECD-----PRLS------SQCLHQNGETLYNSGDTWVQN-CQQC 772
Query: 776 ICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADE------ 829
C+ + C+ CP V CE +L + +CCP C+ D + + K DE
Sbjct: 773 RCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRF 832
Query: 830 --ERW--DLDSCTHCYCLQGQTLCS 850
W CT C C G CS
Sbjct: 833 TGSSWIKHGTECTLCQCKNGHICCS 857
Score = 82.0 bits (201), Expect = 3e-15
Identities = 122/524 (23%), Positives = 184/524 (35%), Gaps = 89/524 (16%)
Query: 403 CYANGLILAHGDRWRE-----DDCTFCQCVNGERHCVATVC-GQTCTNPVK-----VPGE 451
CY G +RE D C C C+NG C +C C P+K V G+
Sbjct: 318 CYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDC--PLKSALAYVDGK 375
Query: 452 CCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDH-------NGCRTCQCINTEEL 504
CC C+ GE + + C+ +D +GC C + ++
Sbjct: 376 CCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQI 435
Query: 505 CSERKQGCTLNCPFGFLTDAQNC------------EICECRPRPKKCRPIICDKYCPLGL 552
C + + F ++ NC +C CR + R + YC +
Sbjct: 436 TLSHSC-CKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALRED--NAYCE-DI 491
Query: 553 LKNKHGCDICR----CKKCPELSCSKICPLGFQQ-DSHGCLICKCREASASAGPPILSGT 607
+ G CR C P S IC G+ + D + C + E + +
Sbjct: 492 DECAEGRHYCRENTMCVNTPG-SFMCICKTGYIRIDDYSCT--EHDECITNQHNCDENAL 548
Query: 608 CL-TVDGHHHKNEESWHDGCREC--YCLNG-REMCALITCPVPACGNPTIHPGQCCPS-- 661
C TV GH+ + + C +C +G R A I V AC P G C +
Sbjct: 549 CFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCAC--PQGFTGPSCETDI 606
Query: 662 --CADDFVVQKPE---LSTPSICHAPGGEYFVEGETWNI--DSCTQCT-CHSGRVLCETE 713
C+D FV ++ P H + + + ++ +SC C +GR C +
Sbjct: 607 DECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAND 666
Query: 714 VCPPLLCQNPSRTQDSCCPQ---CTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPD 770
+C N D CP CT ++N +ND
Sbjct: 667 T----ICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDR------------- 709
Query: 771 VCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKA-YADE 829
C+ C C + + C C CE P + CCP C D H +G+ Y
Sbjct: 710 -CSVCSCQNGFVMCRRMVC---DCENPTVDLF-CCPEC--DPRLSSQCLHQNGETLYNSG 762
Query: 830 ERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMC 873
+ W + +C C CLQG+ C + CP + C I E CCP C
Sbjct: 763 DTW-VQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRC 805
>gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens]
Length = 816
Score = 115 bits (288), Expect = 2e-25
Identities = 144/625 (23%), Positives = 217/625 (34%), Gaps = 162/625 (25%)
Query: 282 DGCCTLPTRCECLSG-------LCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKP 334
DGC C CL+G +C P C + S V GKCC EC K
Sbjct: 289 DGC----KNCTCLNGTIQCETLICPNPDCPLKSALAYVD------GKCCK--EC----KS 332
Query: 335 ACVFNNVEYYDGDMFRMDN----CRFCRCQGG-VAICFTAQCGEINCERYY--VPEGECC 387
C F Y++G+ + + C C+ + + ++ C ++C + CC
Sbjct: 333 ICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCC 392
Query: 388 PVCEDPVYPF-NNPAGCYANGLILAHGDR-----------WREDDCTFCQ----CVNGER 431
VC+ Y F + C N + DR RED+ +C+ C G
Sbjct: 393 KVCKG--YDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNA-YCEDIDECAEGRH 449
Query: 432 HCVA-TVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDH 490
+C T+C V PG +C+ I +D +C E C +C D
Sbjct: 450 YCRENTMC-------VNTPGSFMCICKTG-YIRIDDYSCTEHDECITNQHNC------DE 495
Query: 491 NGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPL 550
N LC G C G+ + C+ C C
Sbjct: 496 NA-----------LCFNTVGGHNCVCKPGYTGNGTTCKA-------------FCKDGC-- 529
Query: 551 GLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLT 610
+N C CP+ C + S G + C R C+
Sbjct: 530 ---RNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSR------------ANCIN 574
Query: 611 VDGHHHKNEESWHDGCRECYCLNGREMCALITCP-VPACGNPTIHPGQCCPSCADDFVVQ 669
+ G +H CR+ Y NG + +C + CG SCA+D +
Sbjct: 575 LPGWYHCE-------CRDGYHDNGMFSPSGESCEDIDECGTGR-------HSCANDTICF 620
Query: 670 KPELSTPSICHAPGGEYFV-----------EGETWNI--DSCTQCTCHSGRVLCETEVCP 716
L C P G+ G+ W + D C+ C+C +G V+C VC
Sbjct: 621 N--LDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCD 678
Query: 717 PLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGD-IFLAAESWKPDVCTSC 775
C+NP+ CCP+C P LS + C + G+ ++ + ++W + C C
Sbjct: 679 ---CENPT-VDLFCCPECD-----PRLS------SQCLHQNGETLYNSGDTWVQN-CQQC 722
Query: 776 ICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADE------ 829
C+ + C+ CP V CE +L + +CCP C+ D + + K DE
Sbjct: 723 RCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRF 782
Query: 830 --ERW--DLDSCTHCYCLQGQTLCS 850
W CT C C G CS
Sbjct: 783 TGSSWIKHGTECTLCQCKNGHICCS 807
Score = 82.0 bits (201), Expect = 3e-15
Identities = 122/524 (23%), Positives = 184/524 (35%), Gaps = 89/524 (16%)
Query: 403 CYANGLILAHGDRWRE-----DDCTFCQCVNGERHCVATVC-GQTCTNPVK-----VPGE 451
CY G +RE D C C C+NG C +C C P+K V G+
Sbjct: 268 CYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDC--PLKSALAYVDGK 325
Query: 452 CCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDH-------NGCRTCQCINTEEL 504
CC C+ GE + + C+ +D +GC C + ++
Sbjct: 326 CCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQI 385
Query: 505 CSERKQGCTLNCPFGFLTDAQNC------------EICECRPRPKKCRPIICDKYCPLGL 552
C + + F ++ NC +C CR + R + YC +
Sbjct: 386 TLSHSC-CKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALRED--NAYCE-DI 441
Query: 553 LKNKHGCDICR----CKKCPELSCSKICPLGFQQ-DSHGCLICKCREASASAGPPILSGT 607
+ G CR C P S IC G+ + D + C + E + +
Sbjct: 442 DECAEGRHYCRENTMCVNTPG-SFMCICKTGYIRIDDYSCT--EHDECITNQHNCDENAL 498
Query: 608 CL-TVDGHHHKNEESWHDGCREC--YCLNG-REMCALITCPVPACGNPTIHPGQCCPS-- 661
C TV GH+ + + C +C +G R A I V AC P G C +
Sbjct: 499 CFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCAC--PQGFTGPSCETDI 556
Query: 662 --CADDFVVQKPE---LSTPSICHAPGGEYFVEGETWNI--DSCTQCT-CHSGRVLCETE 713
C+D FV ++ P H + + + ++ +SC C +GR C +
Sbjct: 557 DECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAND 616
Query: 714 VCPPLLCQNPSRTQDSCCPQ---CTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPD 770
+C N D CP CT ++N +ND
Sbjct: 617 T----ICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDR------------- 659
Query: 771 VCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKA-YADE 829
C+ C C + + C C CE P + CCP C D H +G+ Y
Sbjct: 660 -CSVCSCQNGFVMCRRMVC---DCENPTVDLF-CCPEC--DPRLSSQCLHQNGETLYNSG 712
Query: 830 ERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMC 873
+ W + +C C CLQG+ C + CP + C I E CCP C
Sbjct: 713 DTW-VQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRC 755
>gi|221316561 chordin-like 1 isoform 1 precursor [Homo sapiens]
Length = 458
Score = 96.7 bits (239), Expect = 1e-19
Identities = 74/285 (25%), Positives = 104/285 (36%), Gaps = 22/285 (7%)
Query: 626 CRECYCL-NGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPG- 683
C C C NG +C+ + CP C +P P CCP C +D + T C G
Sbjct: 62 CVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPEDSLPPVNNKVTSKSCEYNGT 121
Query: 684 ----GEYFV-EGETWNI--DSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTD 736
GE FV EG N + CTQC+C G V C + CP L C P DSCC C
Sbjct: 122 TYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRG 181
Query: 737 QPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCER 796
+ + N E + P + S + ++
Sbjct: 182 DGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSRQAGGLSRFPGARSHRGALMDSQQ 241
Query: 797 PVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERW-------DLDSCTHCYCLQGQTLC 849
G I + VC +GK Y+ E W + C C C + C
Sbjct: 242 ---ASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQEC 298
Query: 850 STVSCP-PLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRG 893
+ CP PC P ++G CC +CP E +P + +++G
Sbjct: 299 KKIHCPNRYPCKYPQKIDGKCCKVCPGKKAKE--ELPGQSFDNKG 341
Score = 78.6 bits (192), Expect = 3e-14
Identities = 43/136 (31%), Positives = 61/136 (44%), Gaps = 23/136 (16%)
Query: 761 FLAAESWKPDV-------CTSCICIDSV-ISCFSESCPSVSCERPVLRKGQCCPYCIEDT 812
+ E W P + C +CIC ++ + C CP+V C PV CCP C ED+
Sbjct: 44 YRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPEDS 103
Query: 813 IP---KKVV---CHFSGKAYADEERWDLDS---------CTHCYCLQGQTLCSTVSCPPL 857
+P KV C ++G Y E + + CT C C +G C +CP L
Sbjct: 104 LPPVNNKVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKL 163
Query: 858 PCVEPINVEGSCCPMC 873
C P++V SCC +C
Sbjct: 164 TCAFPVSVPDSCCRVC 179
Score = 72.0 bits (175), Expect = 3e-12
Identities = 37/128 (28%), Positives = 59/128 (46%), Gaps = 7/128 (5%)
Query: 691 ETWNIDSCTQCTC-HSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSV 749
E + + C C C +G VLC CP + C +P CCP+C + P ++ S
Sbjct: 55 EPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPEDSLPPVNNKVTSK 114
Query: 750 P---NYCKNDEGDIFLAA---ESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQ 803
N G++F+A ++ +P+ CT C C + + C ++CP ++C PV
Sbjct: 115 SCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDS 174
Query: 804 CCPYCIED 811
CC C D
Sbjct: 175 CCRVCRGD 182
Score = 67.4 bits (163), Expect = 7e-11
Identities = 45/153 (29%), Positives = 67/153 (43%), Gaps = 24/153 (15%)
Query: 327 ECVNDTKPACVFNNVEYYDGDMFR-------MDNCRFCRC-QGGVAICFTAQCGEINC-E 377
E V ++ C+F + +Y G+ + + C C C + G +C +C ++C
Sbjct: 28 EQVKHSETYCMFQDKKYRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLS 87
Query: 378 RYYVPEGECCPVC-EDPVYPFNNPA---GCYANGLILAHGDRW---------REDDCTFC 424
++P CCP C ED + P NN C NG HG+ + + + CT C
Sbjct: 88 PVHIPH-LCCPRCPEDSLPPVNNKVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQC 146
Query: 425 QCVNGERHCVATVCGQ-TCTNPVKVPGECCPVC 456
C G +C C + TC PV VP CC VC
Sbjct: 147 SCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVC 179
Score = 58.9 bits (141), Expect = 2e-08
Identities = 28/73 (38%), Positives = 36/73 (49%), Gaps = 8/73 (10%)
Query: 819 CHFSGKAYADEERWD-------LDSCTHCYCLQ-GQTLCSTVSCPPLPCVEPINVEGSCC 870
C F K Y ERW L C +C C + G LCS V CP + C+ P+++ CC
Sbjct: 37 CMFQDKKYRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCC 96
Query: 871 PMCPEMYVPEPTN 883
P CPE +P N
Sbjct: 97 PRCPEDSLPPVNN 109
Score = 45.8 bits (107), Expect = 2e-04
Identities = 62/274 (22%), Positives = 86/274 (31%), Gaps = 44/274 (16%)
Query: 421 CTFCQCV-NGERHCVATVCGQT-CTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLT 478
C C C NG C C C +PV +P CCP C E ++ PP N +T
Sbjct: 62 CVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPEDSL----PPV-----NNKVT 112
Query: 479 GKDC-INGFKRDH---------------NGCRTCQCINTEELCSERKQGCTLNCPFGFLT 522
K C NG H N C C C C K L C F
Sbjct: 113 SKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCG-LKTCPKLTCAFPVSV 171
Query: 523 DAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQ 582
C +C D + + +H P + +
Sbjct: 172 PDSCCRVCR-GDGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSRQAGGLSRFPGAR 230
Query: 583 DSHGCLICKCREASASAGPPILS-----GTCLTVDGHHHKNEESWHDG--------CREC 629
G L+ ++AS + +++ G +G + + ESWH C C
Sbjct: 231 SHRGALM-DSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLC 289
Query: 630 YCLNGREMCALITCPVP-ACGNPTIHPGQCCPSC 662
C ++ C I CP C P G+CC C
Sbjct: 290 TCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVC 323
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/126 (24%), Positives = 46/126 (36%), Gaps = 11/126 (8%)
Query: 547 YCPLGLLKNKHGCDICRCKKCPELSCSK------ICPLGFQQDSHGCLICKCREASASA- 599
YC + + +++G +C +CP + C +C +DS + K S
Sbjct: 61 YC-VNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPEDSLPPVNNKVTSKSCEYN 119
Query: 600 GPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCC 659
G G +G + + C +C C G C L TCP C P P CC
Sbjct: 120 GTTYQHGELFVAEGLFQNRQPNQ---CTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCC 176
Query: 660 PSCADD 665
C D
Sbjct: 177 RVCRGD 182
Score = 42.4 bits (98), Expect = 0.002
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 9/63 (14%)
Query: 403 CYANGLILAHGDRWRED-------DCTFCQCVNGERHCVATVCGQT--CTNPVKVPGECC 453
C +NG +HG+ W + +C C C ++ C C C P K+ G+CC
Sbjct: 261 CVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCC 320
Query: 454 PVC 456
VC
Sbjct: 321 KVC 323
Score = 36.6 bits (83), Expect = 0.13
Identities = 23/88 (26%), Positives = 32/88 (36%), Gaps = 16/88 (18%)
Query: 319 PGKCC-----DVFECVND--TKPACVFNNVEYYDGDMF---------RMDNCRFCRCQGG 362
P CC D VN+ T +C +N Y G++F + + C C C G
Sbjct: 92 PHLCCPRCPEDSLPPVNNKVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEG 151
Query: 363 VAICFTAQCGEINCERYYVPEGECCPVC 390
C C ++ C CC VC
Sbjct: 152 NVYCGLKTCPKLTCAFPVSVPDSCCRVC 179
>gi|221316563 chordin-like 1 isoform 2 precursor [Homo sapiens]
Length = 457
Score = 94.7 bits (234), Expect = 4e-19
Identities = 74/285 (25%), Positives = 106/285 (37%), Gaps = 23/285 (8%)
Query: 626 CRECYCL-NGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPG- 683
C C C NG +C+ + CP C +P P CCP C D ++++ S C G
Sbjct: 62 CVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSLPPVNNKVTSKS-CEYNGT 120
Query: 684 ----GEYFV-EGETWNI--DSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTD 736
GE FV EG N + CTQC+C G V C + CP L C P DSCC C
Sbjct: 121 TYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRG 180
Query: 737 QPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCER 796
+ + N E + P + S + ++
Sbjct: 181 DGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSRQAGGLSRFPGARSHRGALMDSQQ 240
Query: 797 PVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERW-------DLDSCTHCYCLQGQTLC 849
G I + VC +GK Y+ E W + C C C + C
Sbjct: 241 ---ASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQEC 297
Query: 850 STVSCP-PLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRG 893
+ CP PC P ++G CC +CP E +P + +++G
Sbjct: 298 KKIHCPNRYPCKYPQKIDGKCCKVCPGKKAKE--ELPGQSFDNKG 340
Score = 73.9 bits (180), Expect = 7e-13
Identities = 37/127 (29%), Positives = 59/127 (46%), Gaps = 6/127 (4%)
Query: 691 ETWNIDSCTQCTC-HSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQ--PFRPSLSRNN 747
E + + C C C +G VLC CP + C +P CCP+C D P ++ +
Sbjct: 55 EPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSLPPVNNKVTSKS 114
Query: 748 SVPNYCKNDEGDIFLAA---ESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQC 804
N G++F+A ++ +P+ CT C C + + C ++CP ++C PV C
Sbjct: 115 CEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSC 174
Query: 805 CPYCIED 811
C C D
Sbjct: 175 CRVCRGD 181
Score = 72.8 bits (177), Expect = 2e-12
Identities = 41/135 (30%), Positives = 58/135 (42%), Gaps = 22/135 (16%)
Query: 761 FLAAESWKPDV-------CTSCICIDSV-ISCFSESCPSVSCERPVLRKGQCCPYCIEDT 812
+ E W P + C +CIC ++ + C CP+V C PV CCP C +
Sbjct: 44 YRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSL 103
Query: 813 IP--KKVV---CHFSGKAYADEERWDLDS---------CTHCYCLQGQTLCSTVSCPPLP 858
P KV C ++G Y E + + CT C C +G C +CP L
Sbjct: 104 PPVNNKVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLT 163
Query: 859 CVEPINVEGSCCPMC 873
C P++V SCC +C
Sbjct: 164 CAFPVSVPDSCCRVC 178
Score = 69.7 bits (169), Expect = 1e-11
Identities = 44/152 (28%), Positives = 66/152 (43%), Gaps = 23/152 (15%)
Query: 327 ECVNDTKPACVFNNVEYYDGDMFR-------MDNCRFCRC-QGGVAICFTAQCGEINC-E 377
E V ++ C+F + +Y G+ + + C C C + G +C +C ++C
Sbjct: 28 EQVKHSETYCMFQDKKYRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLS 87
Query: 378 RYYVPEGECCPVCEDPVYPFNNPA---GCYANGLILAHGDRW---------REDDCTFCQ 425
++P CCP C D + P NN C NG HG+ + + + CT C
Sbjct: 88 PVHIPH-LCCPRCPDSLPPVNNKVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCS 146
Query: 426 CVNGERHCVATVCGQ-TCTNPVKVPGECCPVC 456
C G +C C + TC PV VP CC VC
Sbjct: 147 CSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVC 178
Score = 58.2 bits (139), Expect = 4e-08
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 8/83 (9%)
Query: 819 CHFSGKAYADEERWD-------LDSCTHCYCLQ-GQTLCSTVSCPPLPCVEPINVEGSCC 870
C F K Y ERW L C +C C + G LCS V CP + C+ P+++ CC
Sbjct: 37 CMFQDKKYRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCC 96
Query: 871 PMCPEMYVPEPTNIPIEKTNHRG 893
P CP+ P + + + G
Sbjct: 97 PRCPDSLPPVNNKVTSKSCEYNG 119
Score = 42.7 bits (99), Expect = 0.002
Identities = 31/129 (24%), Positives = 49/129 (37%), Gaps = 18/129 (13%)
Query: 547 YCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLIC-KCREASASAGPPILS 605
YC + + +++G +C +CP + C + P+ L C +C ++ + S
Sbjct: 61 YC-VNCICSENGNVLCSRVRCPNVHC--LSPVHIPH-----LCCPRCPDSLPPVNNKVTS 112
Query: 606 GTCLTVDGHHHKNEESWHDG---------CRECYCLNGREMCALITCPVPACGNPTIHPG 656
+C + E +G C +C C G C L TCP C P P
Sbjct: 113 KSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPD 172
Query: 657 QCCPSCADD 665
CC C D
Sbjct: 173 SCCRVCRGD 181
Score = 42.7 bits (99), Expect = 0.002
Identities = 61/274 (22%), Positives = 84/274 (30%), Gaps = 45/274 (16%)
Query: 421 CTFCQCV-NGERHCVATVCGQT-CTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLT 478
C C C NG C C C +PV +P CCP C + PP N +T
Sbjct: 62 CVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSL-----PPV-----NNKVT 111
Query: 479 GKDC-INGFKRDH---------------NGCRTCQCINTEELCSERKQGCTLNCPFGFLT 522
K C NG H N C C C C K L C F
Sbjct: 112 SKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCG-LKTCPKLTCAFPVSV 170
Query: 523 DAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQ 582
C +C D + + +H P + +
Sbjct: 171 PDSCCRVCR-GDGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSRQAGGLSRFPGAR 229
Query: 583 DSHGCLICKCREASASAGPPILS-----GTCLTVDGHHHKNEESWHDG--------CREC 629
G L+ ++AS + +++ G +G + + ESWH C C
Sbjct: 230 SHRGALM-DSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLC 288
Query: 630 YCLNGREMCALITCPVP-ACGNPTIHPGQCCPSC 662
C ++ C I CP C P G+CC C
Sbjct: 289 TCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVC 322
Score = 42.4 bits (98), Expect = 0.002
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 9/63 (14%)
Query: 403 CYANGLILAHGDRWRED-------DCTFCQCVNGERHCVATVCGQT--CTNPVKVPGECC 453
C +NG +HG+ W + +C C C ++ C C C P K+ G+CC
Sbjct: 260 CVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCC 319
Query: 454 PVC 456
VC
Sbjct: 320 KVC 322
>gi|34147715 chordin-like 1 isoform 3 precursor [Homo sapiens]
Length = 456
Score = 94.4 bits (233), Expect = 5e-19
Identities = 71/266 (26%), Positives = 98/266 (36%), Gaps = 21/266 (7%)
Query: 626 CRECYCL-NGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPG- 683
C C C NG +C+ + CP C +P P CCP C D ++++ S C G
Sbjct: 62 CVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSLPPVNNKVTSKS-CEYNGT 120
Query: 684 ----GEYFV-EGETWNI--DSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTD 736
GE FV EG N + CTQC+C G V C + CP L C P DSCC C
Sbjct: 121 TYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRG 180
Query: 737 QPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCER 796
+ + N E + P + S + ++
Sbjct: 181 DGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSRQAGGLSRFPGARSHRGALMDSQQ 240
Query: 797 PVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERW-------DLDSCTHCYCLQGQTLC 849
G I + VC +GK Y+ E W + C C C + C
Sbjct: 241 ---ASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQEC 297
Query: 850 STVSCP-PLPCVEPINVEGSCCPMCP 874
+ CP PC P ++G CC +CP
Sbjct: 298 KKIHCPNRYPCKYPQKIDGKCCKVCP 323
Score = 73.9 bits (180), Expect = 7e-13
Identities = 37/127 (29%), Positives = 59/127 (46%), Gaps = 6/127 (4%)
Query: 691 ETWNIDSCTQCTC-HSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQ--PFRPSLSRNN 747
E + + C C C +G VLC CP + C +P CCP+C D P ++ +
Sbjct: 55 EPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSLPPVNNKVTSKS 114
Query: 748 SVPNYCKNDEGDIFLAA---ESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQC 804
N G++F+A ++ +P+ CT C C + + C ++CP ++C PV C
Sbjct: 115 CEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSC 174
Query: 805 CPYCIED 811
C C D
Sbjct: 175 CRVCRGD 181
Score = 72.8 bits (177), Expect = 2e-12
Identities = 41/135 (30%), Positives = 58/135 (42%), Gaps = 22/135 (16%)
Query: 761 FLAAESWKPDV-------CTSCICIDSV-ISCFSESCPSVSCERPVLRKGQCCPYCIEDT 812
+ E W P + C +CIC ++ + C CP+V C PV CCP C +
Sbjct: 44 YRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSL 103
Query: 813 IP--KKVV---CHFSGKAYADEERWDLDS---------CTHCYCLQGQTLCSTVSCPPLP 858
P KV C ++G Y E + + CT C C +G C +CP L
Sbjct: 104 PPVNNKVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLT 163
Query: 859 CVEPINVEGSCCPMC 873
C P++V SCC +C
Sbjct: 164 CAFPVSVPDSCCRVC 178
Score = 69.7 bits (169), Expect = 1e-11
Identities = 44/152 (28%), Positives = 66/152 (43%), Gaps = 23/152 (15%)
Query: 327 ECVNDTKPACVFNNVEYYDGDMFR-------MDNCRFCRC-QGGVAICFTAQCGEINC-E 377
E V ++ C+F + +Y G+ + + C C C + G +C +C ++C
Sbjct: 28 EQVKHSETYCMFQDKKYRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLS 87
Query: 378 RYYVPEGECCPVCEDPVYPFNNPA---GCYANGLILAHGDRW---------REDDCTFCQ 425
++P CCP C D + P NN C NG HG+ + + + CT C
Sbjct: 88 PVHIPH-LCCPRCPDSLPPVNNKVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCS 146
Query: 426 CVNGERHCVATVCGQ-TCTNPVKVPGECCPVC 456
C G +C C + TC PV VP CC VC
Sbjct: 147 CSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVC 178
Score = 58.2 bits (139), Expect = 4e-08
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 8/83 (9%)
Query: 819 CHFSGKAYADEERWD-------LDSCTHCYCLQ-GQTLCSTVSCPPLPCVEPINVEGSCC 870
C F K Y ERW L C +C C + G LCS V CP + C+ P+++ CC
Sbjct: 37 CMFQDKKYRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCC 96
Query: 871 PMCPEMYVPEPTNIPIEKTNHRG 893
P CP+ P + + + G
Sbjct: 97 PRCPDSLPPVNNKVTSKSCEYNG 119
Score = 42.7 bits (99), Expect = 0.002
Identities = 31/129 (24%), Positives = 49/129 (37%), Gaps = 18/129 (13%)
Query: 547 YCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLIC-KCREASASAGPPILS 605
YC + + +++G +C +CP + C + P+ L C +C ++ + S
Sbjct: 61 YC-VNCICSENGNVLCSRVRCPNVHC--LSPVHIPH-----LCCPRCPDSLPPVNNKVTS 112
Query: 606 GTCLTVDGHHHKNEESWHDG---------CRECYCLNGREMCALITCPVPACGNPTIHPG 656
+C + E +G C +C C G C L TCP C P P
Sbjct: 113 KSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPD 172
Query: 657 QCCPSCADD 665
CC C D
Sbjct: 173 SCCRVCRGD 181
Score = 42.7 bits (99), Expect = 0.002
Identities = 61/274 (22%), Positives = 84/274 (30%), Gaps = 45/274 (16%)
Query: 421 CTFCQCV-NGERHCVATVCGQT-CTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLT 478
C C C NG C C C +PV +P CCP C + PP N +T
Sbjct: 62 CVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSL-----PPV-----NNKVT 111
Query: 479 GKDC-INGFKRDH---------------NGCRTCQCINTEELCSERKQGCTLNCPFGFLT 522
K C NG H N C C C C K L C F
Sbjct: 112 SKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCG-LKTCPKLTCAFPVSV 170
Query: 523 DAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQ 582
C +C D + + +H P + +
Sbjct: 171 PDSCCRVCR-GDGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSRQAGGLSRFPGAR 229
Query: 583 DSHGCLICKCREASASAGPPILS-----GTCLTVDGHHHKNEESWHDG--------CREC 629
G L+ ++AS + +++ G +G + + ESWH C C
Sbjct: 230 SHRGALM-DSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLC 288
Query: 630 YCLNGREMCALITCPVP-ACGNPTIHPGQCCPSC 662
C ++ C I CP C P G+CC C
Sbjct: 289 TCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVC 322
Score = 42.4 bits (98), Expect = 0.002
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 9/63 (14%)
Query: 403 CYANGLILAHGDRWRED-------DCTFCQCVNGERHCVATVCGQT--CTNPVKVPGECC 453
C +NG +HG+ W + +C C C ++ C C C P K+ G+CC
Sbjct: 260 CVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCC 319
Query: 454 PVC 456
VC
Sbjct: 320 KVC 322
>gi|40353769 chordin-like 2 [Homo sapiens]
Length = 451
Score = 92.8 bits (229), Expect = 1e-18
Identities = 79/304 (25%), Positives = 103/304 (33%), Gaps = 65/304 (21%)
Query: 613 GHHHKNEESWHDG--------CRECYCLNGREM-CALITCPVPACGNPTIHPGQCCPSCA 663
G + ESWH C C C G + C + CP C P P QCCP C
Sbjct: 37 GKRYSPGESWHPYLEPQGLMYCLRCTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCV 96
Query: 664 DDFVVQKPELSTPSICHAP------GGEYFVEGETWNI---------DSCTQCTCHSGRV 708
E TPS AP G + GE ++ + C C+C G++
Sbjct: 97 --------EPHTPSGLRAPPKSCQHNGTMYQHGEIFSAHELFPSRLPNQCVLCSCTEGQI 148
Query: 709 LCETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNY---------CKNDEGD 759
C CP C P DSCC C D+ S +SV + C +D G
Sbjct: 149 YCGLTTCPEPGCPAPLPLPDSCCQACKDEASEQS-DEEDSVQSLHGVRHPQDPCSSDAGR 207
Query: 760 IFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVC 819
P + + F + + VL++ K C
Sbjct: 208 ---KRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTVKIVLKEKH------------KKAC 252
Query: 820 HFSGKAYADEERWDLD-------SCTHCYCLQGQTLCSTVSCPP-LPCVEPINVEGSCCP 871
GK Y+ E W C C C G+ C V+CP PC P V G CC
Sbjct: 253 VHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPCRHPEKVAGKCCK 312
Query: 872 MCPE 875
+CPE
Sbjct: 313 ICPE 316
Score = 75.9 bits (185), Expect = 2e-13
Identities = 88/404 (21%), Positives = 132/404 (32%), Gaps = 113/404 (27%)
Query: 336 CVFNNVEYYDGDMFR-------MDNCRFCRCQGGVAI-CFTAQCGEINCERYYVPEGECC 387
C+F+ Y G+ + + C C C G + C+ C ++C + +CC
Sbjct: 33 CLFHGKRYSPGESWHPYLEPQGLMYCLRCTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCC 92
Query: 388 PVCEDPVYPFN---NPAGCYANGLILAHGDRWR---------EDDCTFCQCVNGERHCVA 435
P C +P P P C NG + HG+ + + C C C G+ +C
Sbjct: 93 PKCVEPHTPSGLRAPPKSCQHNGTMYQHGEIFSAHELFPSRLPNQCVLCSCTEGQIYCGL 152
Query: 436 TVCGQT-CTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCR 494
T C + C P+ +P CC C++ D ++G + + C
Sbjct: 153 TTCPEPGCPAPLPLPDSCCQACKDEASEQSDEE----------DSVQSLHGVRHPQDPCS 202
Query: 495 TCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLK 554
+ + RK+G P G P+ RP +LK
Sbjct: 203 S---------DAGRKRGPGTPAPTGLSAPLSFI--------PRHFRPKGAGSTTVKIVLK 245
Query: 555 NKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGP-PILSGTCLTVDG 613
KH K C G + SHG + A + GP P + TC
Sbjct: 246 EKH---------------KKACVHGGKTYSHGEV---WHPAFRAFGPLPCILCTC----- 282
Query: 614 HHHKNEESWHDGCRECYCLNGREMCALITCPVP-ACGNPTIHPGQCCPSCADDFVVQKPE 672
+GR+ C +TCP C +P G+CC C +D K +
Sbjct: 283 ------------------EDGRQDCQRVTCPTEYPCRHPEKVAGKCCKICPED----KAD 320
Query: 673 LSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCP 716
I S T+C GRVL T V P
Sbjct: 321 PGHSEI------------------SSTRCPKAPGRVLVHTSVSP 346
Score = 57.0 bits (136), Expect = 9e-08
Identities = 27/83 (32%), Positives = 36/83 (43%), Gaps = 8/83 (9%)
Query: 819 CHFSGKAYADEERWD-------LDSCTHCYCLQGQTL-CSTVSCPPLPCVEPINVEGSCC 870
C F GK Y+ E W L C C C +G + C + CPP+ C +P+ CC
Sbjct: 33 CLFHGKRYSPGESWHPYLEPQGLMYCLRCTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCC 92
Query: 871 PMCPEMYVPEPTNIPIEKTNHRG 893
P C E + P P + H G
Sbjct: 93 PKCVEPHTPSGLRAPPKSCQHNG 115
Score = 48.5 bits (114), Expect = 3e-05
Identities = 60/273 (21%), Positives = 81/273 (29%), Gaps = 85/273 (31%)
Query: 559 CDICRCKKCPELSCSKI------CPLGFQQDSHGCLICKCREASASAG---PPILSGTCL 609
C C C + +SC ++ CP + C KC E +G PP
Sbjct: 58 CLRCTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCP--KCVEPHTPSGLRAPPKSCQHNG 115
Query: 610 TVDGH------HHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPG---QCC- 659
T+ H H + C C C G+ C L TCP P C P P Q C
Sbjct: 116 TMYQHGEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACK 175
Query: 660 ------------------------PSCADDFVVQKPELSTPSICHAP------------- 682
P +D + P P+ AP
Sbjct: 176 DEASEQSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGA 235
Query: 683 -------------------GGEYFVEGETWNID-------SCTQCTCHSGRVLCETEVCP 716
GG+ + GE W+ C CTC GR C+ CP
Sbjct: 236 GSTTVKIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCP 295
Query: 717 -PLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNS 748
C++P + CC C + P S +S
Sbjct: 296 TEYPCRHPEKVAGKCCKICPEDKADPGHSEISS 328
>gi|30089980 chordin [Homo sapiens]
Length = 955
Score = 84.7 bits (208), Expect = 4e-16
Identities = 78/286 (27%), Positives = 106/286 (37%), Gaps = 45/286 (15%)
Query: 634 GREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVEGETW 693
G E + P A P + PG + A +P P+ C G + G W
Sbjct: 662 GAEGVRALGAPDTASAAPPVVPGLPALAPAKPGGPGRPR--DPNTCFFEGQQR-PHGARW 718
Query: 694 --NIDS-CTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTD-QPFR--PSLSRNN 747
N D C+ CTC V+C+ VCPP C +P + D CCP C + Q R P L R+
Sbjct: 719 APNYDPLCSLCTCQRRTVICDPVVCPPPSCPHPVQAPDQCCPVCPEKQDVRDLPGLPRSR 778
Query: 748 SVPNYCKNDEGDIFLAAES-WKPDV-------CTSCICIDSV--ISCFSESCPSVSCERP 797
C D + AA + W P V C C C + C CP ++C +P
Sbjct: 779 DPGEGCYFDGDRSWRAAGTRWHPVVPPFGLIKCAVCTCKGGTGEVHCEKVQCPRLACAQP 838
Query: 798 V-LRKGQCCPYC-------------IEDTIPKKVVCHFSGKAYADEERWDLD-------S 836
V + CC C ++ P+ C F+G+ + + + W S
Sbjct: 839 VRVNPTDCCKQCPVGSGAHPQLGDPMQADGPRG--CRFAGQWFPESQSWHPSVPPFGEMS 896
Query: 837 CTHCYCLQGQTLCSTVSCP-PLPCVEPINVEGSCCPMCPEMYVPEP 881
C C C G C C PL C E CC C P P
Sbjct: 897 CITCRCGAGVPHCERDDCSLPLSCGS--GKESRCCSRCTAHRRPAP 940
Score = 80.1 bits (196), Expect = 1e-14
Identities = 72/265 (27%), Positives = 97/265 (36%), Gaps = 58/265 (21%)
Query: 596 SASAGPPILSG-------------------TCLTVDGHHHKNEESWHDG----CRECYCL 632
+ASA PP++ G TC +G + W C C C
Sbjct: 674 TASAAPPVVPGLPALAPAKPGGPGRPRDPNTCF-FEGQQRPHGARWAPNYDPLCSLCTCQ 732
Query: 633 NGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPG-GEYFVEGE 691
+C + CP P+C +P P QCCP C + V+ +L PG G YF
Sbjct: 733 RRTVICDPVVCPPPSCPHPVQAPDQCCPVCPEKQDVR--DLPGLPRSRDPGEGCYFDGDR 790
Query: 692 TW--------------NIDSCTQCTCH--SGRVLCETEVCPPLLCQNPSRTQDS-CCPQC 734
+W + C CTC +G V CE CP L C P R + CC QC
Sbjct: 791 SWRAAGTRWHPVVPPFGLIKCAVCTCKGGTGEVHCEKVQCPRLACAQPVRVNPTDCCKQC 850
Query: 735 -TDQPFRPSLS--RNNSVPNYCKNDEGDIFLAAESWKPDV-------CTSCICIDSVISC 784
P L P C+ G F ++SW P V C +C C V C
Sbjct: 851 PVGSGAHPQLGDPMQADGPRGCR-FAGQWFPESQSWHPSVPPFGEMSCITCRCGAGVPHC 909
Query: 785 FSESCP-SVSCERPVLRKGQCCPYC 808
+ C +SC ++ +CC C
Sbjct: 910 ERDDCSLPLSCGSG--KESRCCSRC 932
Score = 63.9 bits (154), Expect = 7e-10
Identities = 62/230 (26%), Positives = 86/230 (37%), Gaps = 43/230 (18%)
Query: 527 CEICECRPRPKKCRPIIC-DKYCPLGLLKNKHGCDICRCKKCPELSCSKICP-LGFQQD- 583
C +C C+ R C P++C CP + D C C CPE + P L +D
Sbjct: 726 CSLCTCQRRTVICDPVVCPPPSCPHPV----QAPDQC-CPVCPEKQDVRDLPGLPRSRDP 780
Query: 584 SHGCLICKCR--EASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCL--NGREMCA 639
GC R A+ + P++ L C C C G C
Sbjct: 781 GEGCYFDGDRSWRAAGTRWHPVVPPFGLI--------------KCAVCTCKGGTGEVHCE 826
Query: 640 LITCPVPACGNPT-IHPGQCCPSCADDFVVQKPELSTPSICHAP-----GGEYFVEGETW 693
+ CP AC P ++P CC C P+L P P G++F E ++W
Sbjct: 827 KVQCPRLACAQPVRVNPTDCCKQCPVGSGAH-PQLGDPMQADGPRGCRFAGQWFPESQSW 885
Query: 694 NID-------SCTQCTCHSGRVLCETEVCP-PLLCQNPSRTQDSCCPQCT 735
+ SC C C +G CE + C PL C S + CC +CT
Sbjct: 886 HPSVPPFGEMSCITCRCGAGVPHCERDDCSLPLSC--GSGKESRCCSRCT 933
Score = 56.6 bits (135), Expect = 1e-07
Identities = 66/280 (23%), Positives = 97/280 (34%), Gaps = 64/280 (22%)
Query: 399 NPAGCYANGLILAHGDRWREDD---CTFCQCVNGERHCVATVCGQ-TCTNPVKVPGECCP 454
+P C+ G HG RW + C+ C C C VC +C +PV+ P +CCP
Sbjct: 701 DPNTCFFEGQQRPHGARWAPNYDPLCSLCTCQRRTVICDPVVCPPPSCPHPVQAPDQCCP 760
Query: 455 VCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELCSERKQGCTL 514
VC E + D P L G+ C +G R+ + T + +
Sbjct: 761 VCPEKQDVR-DLPG---LPRSRDPGEGCY------FDGDRSWRAAGT--------RWHPV 802
Query: 515 NCPFGFLTDAQNCEICECRPRPKK--CRPIICDKY-CPLGLLKNKHGCDICRCKKCPELS 571
PFG + C +C C+ + C + C + C + N C CK+CP +
Sbjct: 803 VPPFGLI----KCAVCTCKGGTGEVHCEKVQCPRLACAQPVRVNPTDC----CKQCP-VG 853
Query: 572 CSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHD------- 624
LG + G C+ G +SWH
Sbjct: 854 SGAHPQLGDPMQADGPRGCR-------------------FAGQWFPESQSWHPSVPPFGE 894
Query: 625 -GCRECYCLNGREMCALITCPVP-ACGNPTIHPGQCCPSC 662
C C C G C C +P +CG+ +CC C
Sbjct: 895 MSCITCRCGAGVPHCERDDCSLPLSCGSG--KESRCCSRC 932
Score = 56.6 bits (135), Expect = 1e-07
Identities = 57/219 (26%), Positives = 74/219 (33%), Gaps = 42/219 (19%)
Query: 354 CRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCED-------PVYPFNNP--AGCY 404
C C CQ IC C +C +CCPVC + P P + GCY
Sbjct: 726 CSLCTCQRRTVICDPVVCPPPSCPHPVQAPDQCCPVCPEKQDVRDLPGLPRSRDPGEGCY 785
Query: 405 ANG--LILAHGDRWRE-------DDCTFCQCV--NGERHCVATVCGQ-TCTNPVKV-PGE 451
+G A G RW C C C GE HC C + C PV+V P +
Sbjct: 786 FDGDRSWRAAGTRWHPVVPPFGLIKCAVCTCKGGTGEVHCEKVQCPRLACAQPVRVNPTD 845
Query: 452 CCPVC-----EEPTIITVDPPACGELSNCTLTGK---------DCINGFKRDHNGCRTCQ 497
CC C P + DP C G+ + F C TC+
Sbjct: 846 CCKQCPVGSGAHPQL--GDPMQADGPRGCRFAGQWFPESQSWHPSVPPF--GEMSCITCR 901
Query: 498 CINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRP 536
C C + C+L G +++ C C RP
Sbjct: 902 CGAGVPHC--ERDDCSLPLSCGSGKESRCCSRCTAHRRP 938
Score = 48.9 bits (115), Expect = 2e-05
Identities = 52/216 (24%), Positives = 68/216 (31%), Gaps = 47/216 (21%)
Query: 282 DGCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNV 341
D C+L T C+ + +C VC S P V P +CC V D +
Sbjct: 723 DPLCSLCT-CQRRTVICDPVVCPPPSCPHPVQ----APDQCCPVCPEKQDVRDLPGLPRS 777
Query: 342 E------YYDGDM---------------FRMDNCRFCRCQGGVAI--CFTAQCGEINCER 378
Y+DGD F + C C C+GG C QC + C +
Sbjct: 778 RDPGEGCYFDGDRSWRAAGTRWHPVVPPFGLIKCAVCTCKGGTGEVHCEKVQCPRLACAQ 837
Query: 379 -YYVPEGECCPVCE----------DPVYPFNNPAGCYANGLILAHGDRWR-------EDD 420
V +CC C DP+ + P GC G W E
Sbjct: 838 PVRVNPTDCCKQCPVGSGAHPQLGDPMQA-DGPRGCRFAGQWFPESQSWHPSVPPFGEMS 896
Query: 421 CTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVC 456
C C+C G HC C + CC C
Sbjct: 897 CITCRCGAGVPHCERDDCSLPLSCGSGKESRCCSRC 932
Score = 40.4 bits (93), Expect = 0.009
Identities = 23/77 (29%), Positives = 29/77 (37%), Gaps = 20/77 (25%)
Query: 819 CHFSGKAYADEERWDLD--------SCTHCYCLQ----------GQTLCSTVS--CPPLP 858
C F GK YA +E W D C C C G+ C + CP
Sbjct: 51 CTFGGKVYALDETWHPDLGEPFGVMRCVLCACEAPQWGRRTRGPGRVSCKNIKPECPTPA 110
Query: 859 CVEPINVEGSCCPMCPE 875
C +P + G CC CP+
Sbjct: 111 CGQPRQLPGHCCQTCPQ 127
Score = 39.7 bits (91), Expect = 0.015
Identities = 25/85 (29%), Positives = 31/85 (36%), Gaps = 21/85 (24%)
Query: 602 PILSGTCLTVDGHHHKNEESWHDG---------CRECYCLN----------GREMCALIT 642
P+ T G + +E+WH C C C GR C I
Sbjct: 44 PVRGAAGCTFGGKVYALDETWHPDLGEPFGVMRCVLCACEAPQWGRRTRGPGRVSCKNIK 103
Query: 643 --CPVPACGNPTIHPGQCCPSCADD 665
CP PACG P PG CC +C +
Sbjct: 104 PECPTPACGQPRQLPGHCCQTCPQE 128
Score = 35.8 bits (81), Expect = 0.21
Identities = 26/103 (25%), Positives = 33/103 (32%), Gaps = 30/103 (29%)
Query: 382 PEGECCPV-CEDPVYPFNNPAGCYANGLILAHGDRWRED--------DCTFC-------- 424
PE P+ E P AGC G + A + W D C C
Sbjct: 29 PEPPVLPIRSEKEPLPVRGAAGCTFGGKVYALDETWHPDLGEPFGVMRCVLCACEAPQWG 88
Query: 425 ---------QCVNGERHCVATVCGQTCTNPVKVPGECCPVCEE 458
C N + C CGQ P ++PG CC C +
Sbjct: 89 RRTRGPGRVSCKNIKPECPTPACGQ----PRQLPGHCCQTCPQ 127
Score = 33.5 bits (75), Expect = 1.1
Identities = 20/75 (26%), Positives = 27/75 (36%), Gaps = 20/75 (26%)
Query: 683 GGEYFVEGETWNID--------SCTQCTCHS----------GRVLCET--EVCPPLLCQN 722
GG+ + ETW+ D C C C + GRV C+ CP C
Sbjct: 54 GGKVYALDETWHPDLGEPFGVMRCVLCACEAPQWGRRTRGPGRVSCKNIKPECPTPACGQ 113
Query: 723 PSRTQDSCCPQCTDQ 737
P + CC C +
Sbjct: 114 PRQLPGHCCQTCPQE 128
Score = 31.6 bits (70), Expect = 4.1
Identities = 18/74 (24%), Positives = 28/74 (37%), Gaps = 20/74 (27%)
Query: 758 GDIFLAAESWKPDV--------CTSCICI----------DSVISC--FSESCPSVSCERP 797
G ++ E+W PD+ C C C +SC CP+ +C +P
Sbjct: 55 GKVYALDETWHPDLGEPFGVMRCVLCACEAPQWGRRTRGPGRVSCKNIKPECPTPACGQP 114
Query: 798 VLRKGQCCPYCIED 811
G CC C ++
Sbjct: 115 RQLPGHCCQTCPQE 128
>gi|116284392 mucin 2 precursor [Homo sapiens]
Length = 5179
Score = 82.4 bits (202), Expect = 2e-15
Identities = 109/417 (26%), Positives = 157/417 (37%), Gaps = 89/417 (21%)
Query: 170 EKPDCSKARCEVQFSPRCPEDSVLIEG-YAPPGECCPLPSRCVC-NPAGCLRKVCQPGNL 227
E+P C + + ++VL+EG + P G P VC GC+ P N
Sbjct: 4775 EEPTCKSSSSQ-------QNNTVLVEGCFCPEGTMNYAPGFDVCVKTCGCVG----PDN- 4822
Query: 228 NILVSKASGKPGECCDLYECKPVF------GVDCRTVECPPVQQTACPPDSYETQVRLT- 280
V + G+ E ++CK G+ C+ C T C D +
Sbjct: 4823 ---VPREFGEHFE----FDCKNCVCLEGGSGIICQPKRCSQKPVTHCVEDGTYLATEVNP 4875
Query: 281 ADGCCTLPTRCECLSGLCGFP--VCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVF 338
AD CC + T C+C + LC VC +G + PG+CC + C ++K CV
Sbjct: 4876 ADTCCNI-TVCKCNTSLCKEKPSVCPLG----FEVKSKMVPGRCCPFYWC--ESKGVCVH 4928
Query: 339 NNVEYYDGDMFRMDNCRFCRCQGGV---AICFTAQCGEINCERYYVP-------EGECCP 388
N EY G C+ C C V + C + C P GECC
Sbjct: 4929 GNAEYQPGSPVYSSKCQDCVCTDKVDNNTLLNVIACTHVPCNTSCSPGFELMEAPGECCK 4988
Query: 389 VCEDPVYPFNNPAGCYANGLILAHGDRWRE--DDCTFCQCVNGERHCVATVCGQTCTN-- 444
CE P + +IL GD + ++CTF CV +++V TC N
Sbjct: 4989 KCEQTHCIIKRPDNQH---VILKPGDFKSDPKNNCTFFSCVKIHNQLISSVSNITCPNFD 5045
Query: 445 -PVKVPGE-------CCPVC---EEPTIITVDPPACGELS--NCTLT----------GKD 481
+ +PG CC C E + P E+S CT T G
Sbjct: 5046 ASICIPGSITFMPNGCCKTCTPRNETRVPCSTVPVTTEVSYAGCTKTVLMNHCSGSCGTF 5105
Query: 482 CINGFKR---DHNGCRTCQCINTEELCSERKQGCTLNCP-FGFLTDA-QNCEICECR 533
+ K DH+ C C+ EE S+R+ L+CP G LT + E C+C+
Sbjct: 5106 VMYSAKAQALDHS-CSCCK----EEKTSQRE--VVLSCPNGGSLTHTYTHIESCQCQ 5155
Score = 47.8 bits (112), Expect = 5e-05
Identities = 68/300 (22%), Positives = 94/300 (31%), Gaps = 74/300 (24%)
Query: 128 NLIAGCNIINGKCEC----NTIRTCSNPFEFPSQD-MCLSALKRIEEEKPDCSKARCEVQ 182
N G ++ C C N R FEF ++ +CL I C RC +
Sbjct: 4803 NYAPGFDVCVKTCGCVGPDNVPREFGEHFEFDCKNCVCLEGGSGII-----CQPKRCSQK 4857
Query: 183 FSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRK--VCQPGNLNILVSKASGKPGE 240
C ED + P + C + C CN + C K VC G K+ PG
Sbjct: 4858 PVTHCVEDGTYLATEVNPADTCCNITVCKCNTSLCKEKPSVCPLG----FEVKSKMVPGR 4913
Query: 241 CCDLYECK----------------PVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGC 284
CC Y C+ PV+ C+ C D + L C
Sbjct: 4914 CCPFYWCESKGVCVHGNAEYQPGSPVYSSKCQDCVC---------TDKVDNNTLLNVIAC 4964
Query: 285 CTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYY 344
+P C GF + E PG+CC E + +V
Sbjct: 4965 THVPCNTSCSP---GFELME-------------APGECCKKCEQTHCIIKRPDNQHVILK 5008
Query: 345 DGDMFRMD---NCRFCRCQGGVAICFTAQCGEINCERY-----------YVPEGECCPVC 390
GD F+ D NC F C + + I C + ++P G CC C
Sbjct: 5009 PGD-FKSDPKNNCTFFSCV-KIHNQLISSVSNITCPNFDASICIPGSITFMPNG-CCKTC 5065
Score = 39.7 bits (91), Expect = 0.015
Identities = 67/332 (20%), Positives = 120/332 (36%), Gaps = 81/332 (24%)
Query: 451 ECCPVCEEPTIITVDPPACGELSNCTLT-GKDCINGFKRDHNG----CRTCQCINTEELC 505
+ C EEPT + + + +N L G C G G +TC C+ + +
Sbjct: 4769 QACGPAEEPTCKS----SSSQQNNTVLVEGCFCPEGTMNYAPGFDVCVKTCGCVGPDNVP 4824
Query: 506 SERKQGCTLNCPFGFLTDAQNCEICECRPRPKKC--RPII---------------CDKYC 548
E + +C + + IC+ PK+C +P+ D C
Sbjct: 4825 REFGEHFEFDCKNCVCLEGGSGIICQ----PKRCSQKPVTHCVEDGTYLATEVNPADTCC 4880
Query: 549 PLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDS-----HGCLICKCREASASAGPPI 603
+ + K C+ CK+ P +CPLGF+ S C C
Sbjct: 4881 NITVCK----CNTSLCKEKPS-----VCPLGFEVKSKMVPGRCCPFYWCES--------- 4922
Query: 604 LSGTCLTVDGHHHKNEESWHDGCRECYC---LNGREMCALITCPVPACG---NPTIH--- 654
G C+ + + + C++C C ++ + +I C C +P
Sbjct: 4923 -KGVCVHGNAEYQPGSPVYSSKCQDCVCTDKVDNNTLLNVIACTHVPCNTSCSPGFELME 4981
Query: 655 -PGQCCPSCADDF-VVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTC---HSGRVL 709
PG+CC C ++++P+ + PG + ++ ++CT +C H+ +
Sbjct: 4982 APGECCKKCEQTHCIIKRPD--NQHVILKPG-----DFKSDPKNNCTFFSCVKIHNQLIS 5034
Query: 710 CETEV-CPPL---LCQNPSRT--QDSCCPQCT 735
+ + CP +C S T + CC CT
Sbjct: 5035 SVSNITCPNFDASICIPGSITFMPNGCCKTCT 5066
Score = 36.2 bits (82), Expect = 0.16
Identities = 55/245 (22%), Positives = 77/245 (31%), Gaps = 53/245 (21%)
Query: 260 CPPVQQTACPPDSYETQVRLTADGC-CTLPTRCECLSGLCGFPVCE-----VG--STPRI 311
C P ++ C S + + +GC C T ++ GF VC VG + PR
Sbjct: 4771 CGPAEEPTCKSSSSQQNNTVLVEGCFCPEGT----MNYAPGFDVCVKTCGCVGPDNVPRE 4826
Query: 312 VSRG-----------DGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQ 360
+G G C C CV + Y ++ D C C
Sbjct: 4827 FGEHFEFDCKNCVCLEGGSGIICQPKRCSQKPVTHCVEDGT-YLATEVNPADTC----CN 4881
Query: 361 GGVAICFTAQCGE--------INCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAH 412
V C T+ C E + VP G CCP Y + C
Sbjct: 4882 ITVCKCNTSLCKEKPSVCPLGFEVKSKMVP-GRCCPF-----YWCESKGVCVHGNAEYQP 4935
Query: 413 GDRWREDDCTFCQCVNGERH--------CVATVCGQTCT---NPVKVPGECCPVCEEPTI 461
G C C C + + C C +C+ ++ PGECC CE+
Sbjct: 4936 GSPVYSSKCQDCVCTDKVDNNTLLNVIACTHVPCNTSCSPGFELMEAPGECCKKCEQTHC 4995
Query: 462 ITVDP 466
I P
Sbjct: 4996 IIKRP 5000
Score = 35.8 bits (81), Expect = 0.21
Identities = 55/227 (24%), Positives = 76/227 (33%), Gaps = 59/227 (25%)
Query: 160 CLSALKRIEEEKPDCSKARCEVQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCL- 218
C + + E C + V CP+ + L E G C PL ++C C G
Sbjct: 674 CQQTCRSLSEADSHCLEGFAPVD-GCGCPDHTFLDE----KGRCVPL-AKCSCYHRGLYL 727
Query: 219 -----------RKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTA 267
R VC+ G L+ + G+ C P +DC + +
Sbjct: 728 EAGDVVVRQEERCVCRDGRLHCRQIRLIGQ--SCT-----APKIHMDCSNLTALATSKPR 780
Query: 268 CPPDSYETQVRLTADGCCTLPT---RCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCD 324
A C TL EC+SG VC G DG G
Sbjct: 781 -------------ALSCQTLAAGYYHTECVSGC----VCPDGLMD------DGRGG---- 813
Query: 325 VFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQC 371
CV + + CV NN Y G ++D C C C+ G +C A C
Sbjct: 814 ---CVVEKECPCVHNNDLYSSGAKIKVD-CNTCTCKRGRWVCTQAVC 856
Score = 34.7 bits (78), Expect = 0.48
Identities = 27/108 (25%), Positives = 41/108 (37%), Gaps = 15/108 (13%)
Query: 543 ICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASA----- 597
+C K CP L+ + G C L S +C + H C C E +
Sbjct: 290 LCPKTCPGNLVYLESGSPCM--DTCSHLEVSSLC------EEHRMDGCFCPEGTVYDDIG 341
Query: 598 -SAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCP 644
S P+ C + GH + + + C +C C GR +C + CP
Sbjct: 342 DSGCVPVSQCHC-RLHGHLYTPGQEITNDCEQCVCNAGRWVCKDLPCP 388
>gi|239749951 PREDICTED: similar to mucin 2 [Homo sapiens]
Length = 2639
Score = 82.4 bits (202), Expect = 2e-15
Identities = 109/417 (26%), Positives = 157/417 (37%), Gaps = 89/417 (21%)
Query: 170 EKPDCSKARCEVQFSPRCPEDSVLIEG-YAPPGECCPLPSRCVC-NPAGCLRKVCQPGNL 227
E+P C + + ++VL+EG + P G P VC GC+ P N
Sbjct: 2235 EEPTCKSSSSQ-------QNNTVLVEGCFCPEGTMNYAPGFDVCVKTCGCVG----PDN- 2282
Query: 228 NILVSKASGKPGECCDLYECKPVF------GVDCRTVECPPVQQTACPPDSYETQVRLT- 280
V + G+ E ++CK G+ C+ C T C D +
Sbjct: 2283 ---VPREFGEHFE----FDCKNCVCLEGGSGIICQPKRCSQKPVTHCVEDGTYLATEVNP 2335
Query: 281 ADGCCTLPTRCECLSGLCGFP--VCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVF 338
AD CC + T C+C + LC VC +G + PG+CC + C ++K CV
Sbjct: 2336 ADTCCNI-TVCKCNTSLCKEKPSVCPLG----FEVKSKMVPGRCCPFYWC--ESKGVCVH 2388
Query: 339 NNVEYYDGDMFRMDNCRFCRCQGGV---AICFTAQCGEINCERYYVP-------EGECCP 388
N EY G C+ C C V + C + C P GECC
Sbjct: 2389 GNAEYQPGSPVYSSKCQDCVCTDKVDNNTLLNVIACTHVPCNTSCSPGFELMEAPGECCK 2448
Query: 389 VCEDPVYPFNNPAGCYANGLILAHGDRWRE--DDCTFCQCVNGERHCVATVCGQTCTN-- 444
CE P + +IL GD + ++CTF CV +++V TC N
Sbjct: 2449 KCEQTHCIIKRPDNQH---VILKPGDFKSDPKNNCTFFSCVKIHNQLISSVSNITCPNFD 2505
Query: 445 -PVKVPGE-------CCPVC---EEPTIITVDPPACGELS--NCTLT----------GKD 481
+ +PG CC C E + P E+S CT T G
Sbjct: 2506 ASICIPGSITFMPNGCCKTCTPRNETRVPCSTVPVTTEVSYAGCTKTVLMNHCSGSCGTF 2565
Query: 482 CINGFKR---DHNGCRTCQCINTEELCSERKQGCTLNCP-FGFLTDA-QNCEICECR 533
+ K DH+ C C+ EE S+R+ L+CP G LT + E C+C+
Sbjct: 2566 VMYSAKAQALDHS-CSCCK----EEKTSQRE--VVLSCPNGGSLTHTYTHIESCQCQ 2615
Score = 47.8 bits (112), Expect = 5e-05
Identities = 68/300 (22%), Positives = 94/300 (31%), Gaps = 74/300 (24%)
Query: 128 NLIAGCNIINGKCEC----NTIRTCSNPFEFPSQD-MCLSALKRIEEEKPDCSKARCEVQ 182
N G ++ C C N R FEF ++ +CL I C RC +
Sbjct: 2263 NYAPGFDVCVKTCGCVGPDNVPREFGEHFEFDCKNCVCLEGGSGII-----CQPKRCSQK 2317
Query: 183 FSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRK--VCQPGNLNILVSKASGKPGE 240
C ED + P + C + C CN + C K VC G K+ PG
Sbjct: 2318 PVTHCVEDGTYLATEVNPADTCCNITVCKCNTSLCKEKPSVCPLG----FEVKSKMVPGR 2373
Query: 241 CCDLYECK----------------PVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGC 284
CC Y C+ PV+ C+ C D + L C
Sbjct: 2374 CCPFYWCESKGVCVHGNAEYQPGSPVYSSKCQDCVC---------TDKVDNNTLLNVIAC 2424
Query: 285 CTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYY 344
+P C GF + E PG+CC E + +V
Sbjct: 2425 THVPCNTSCSP---GFELME-------------APGECCKKCEQTHCIIKRPDNQHVILK 2468
Query: 345 DGDMFRMD---NCRFCRCQGGVAICFTAQCGEINCERY-----------YVPEGECCPVC 390
GD F+ D NC F C + + I C + ++P G CC C
Sbjct: 2469 PGD-FKSDPKNNCTFFSCV-KIHNQLISSVSNITCPNFDASICIPGSITFMPNG-CCKTC 2525
Score = 39.7 bits (91), Expect = 0.015
Identities = 67/332 (20%), Positives = 120/332 (36%), Gaps = 81/332 (24%)
Query: 451 ECCPVCEEPTIITVDPPACGELSNCTLT-GKDCINGFKRDHNG----CRTCQCINTEELC 505
+ C EEPT + + + +N L G C G G +TC C+ + +
Sbjct: 2229 QACGPAEEPTCKS----SSSQQNNTVLVEGCFCPEGTMNYAPGFDVCVKTCGCVGPDNVP 2284
Query: 506 SERKQGCTLNCPFGFLTDAQNCEICECRPRPKKC--RPII---------------CDKYC 548
E + +C + + IC+ PK+C +P+ D C
Sbjct: 2285 REFGEHFEFDCKNCVCLEGGSGIICQ----PKRCSQKPVTHCVEDGTYLATEVNPADTCC 2340
Query: 549 PLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDS-----HGCLICKCREASASAGPPI 603
+ + K C+ CK+ P +CPLGF+ S C C
Sbjct: 2341 NITVCK----CNTSLCKEKPS-----VCPLGFEVKSKMVPGRCCPFYWCES--------- 2382
Query: 604 LSGTCLTVDGHHHKNEESWHDGCRECYC---LNGREMCALITCPVPACG---NPTIH--- 654
G C+ + + + C++C C ++ + +I C C +P
Sbjct: 2383 -KGVCVHGNAEYQPGSPVYSSKCQDCVCTDKVDNNTLLNVIACTHVPCNTSCSPGFELME 2441
Query: 655 -PGQCCPSCADDF-VVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTC---HSGRVL 709
PG+CC C ++++P+ + PG + ++ ++CT +C H+ +
Sbjct: 2442 APGECCKKCEQTHCIIKRPD--NQHVILKPG-----DFKSDPKNNCTFFSCVKIHNQLIS 2494
Query: 710 CETEV-CPPL---LCQNPSRT--QDSCCPQCT 735
+ + CP +C S T + CC CT
Sbjct: 2495 SVSNITCPNFDASICIPGSITFMPNGCCKTCT 2526
Score = 36.2 bits (82), Expect = 0.16
Identities = 55/245 (22%), Positives = 77/245 (31%), Gaps = 53/245 (21%)
Query: 260 CPPVQQTACPPDSYETQVRLTADGC-CTLPTRCECLSGLCGFPVCE-----VG--STPRI 311
C P ++ C S + + +GC C T ++ GF VC VG + PR
Sbjct: 2231 CGPAEEPTCKSSSSQQNNTVLVEGCFCPEGT----MNYAPGFDVCVKTCGCVGPDNVPRE 2286
Query: 312 VSRG-----------DGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQ 360
+G G C C CV + Y ++ D C C
Sbjct: 2287 FGEHFEFDCKNCVCLEGGSGIICQPKRCSQKPVTHCVEDGT-YLATEVNPADTC----CN 2341
Query: 361 GGVAICFTAQCGE--------INCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAH 412
V C T+ C E + VP G CCP Y + C
Sbjct: 2342 ITVCKCNTSLCKEKPSVCPLGFEVKSKMVP-GRCCPF-----YWCESKGVCVHGNAEYQP 2395
Query: 413 GDRWREDDCTFCQCVNGERH--------CVATVCGQTCT---NPVKVPGECCPVCEEPTI 461
G C C C + + C C +C+ ++ PGECC CE+
Sbjct: 2396 GSPVYSSKCQDCVCTDKVDNNTLLNVIACTHVPCNTSCSPGFELMEAPGECCKKCEQTHC 2455
Query: 462 ITVDP 466
I P
Sbjct: 2456 IIKRP 2460
Score = 35.8 bits (81), Expect = 0.21
Identities = 55/227 (24%), Positives = 76/227 (33%), Gaps = 59/227 (25%)
Query: 160 CLSALKRIEEEKPDCSKARCEVQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCL- 218
C + + E C + V CP+ + L E G C PL ++C C G
Sbjct: 575 CQQTCRSLSEADSHCLEGFAPVD-GCGCPDHTFLDE----KGRCVPL-AKCSCYHRGLYL 628
Query: 219 -----------RKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTA 267
R VC+ G L+ + G+ C P +DC + +
Sbjct: 629 EAGDVVVRQEERCVCRDGRLHCRQIRLIGQ--SCT-----APKIHMDCSNLTALATSKPR 681
Query: 268 CPPDSYETQVRLTADGCCTLPT---RCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCD 324
A C TL EC+SG VC G DG G
Sbjct: 682 -------------ALSCQTLAAGYYHTECVSGC----VCPDGLMD------DGRGG---- 714
Query: 325 VFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQC 371
CV + + CV NN Y G ++D C C C+ G +C A C
Sbjct: 715 ---CVVEKECPCVHNNDLYSSGAKIKVD-CNTCTCKRGRWVCTQAVC 757
>gi|89191868 von Willebrand factor preproprotein [Homo sapiens]
Length = 2813
Score = 81.6 bits (200), Expect = 3e-15
Identities = 110/436 (25%), Positives = 149/436 (34%), Gaps = 87/436 (19%)
Query: 171 KPDCSKARCEVQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGC-LRKV--CQPGNL 227
K +C+ C +P C V +CCP CVC+P C L V C+ G
Sbjct: 2288 KVNCTTQPCPTAKAPTCGLCEVA-RLRQNADQCCP-EYECVCDPVSCDLPPVPHCERGLQ 2345
Query: 228 NILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCC-T 286
L + PGEC +P F CR EC V +CPP T L CC
Sbjct: 2346 PTLTN-----PGEC------RPNFTCACRKEECKRVSPPSCPPHRLPT---LRKTQCCDE 2391
Query: 287 LPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDG 346
C C++ P+ + ST T C C+ D CV + Y G
Sbjct: 2392 YECACNCVNSTVSCPLGYLAST--------ATNDCGCTTTTCLPD--KVCVHRSTIYPVG 2441
Query: 347 DMFRMDNCRFCRC---QGGVAICFTAQCGEINCE-------RYYVPEGECCPVCEDPVYP 396
F + C C C + V AQC + CE Y + EGECC C
Sbjct: 2442 -QFWEEGCDVCTCTDMEDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACE 2500
Query: 397 F--NNPAGCYANGLILAHGDRWR--EDDCTFCQCVNGERHCVATVCGQTCTNPVKVP--- 449
+P G + + G +W E+ C +CV + +C ++VP
Sbjct: 2501 VVTGSPRG-DSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRNVSCPQ-LEVPVCP 2558
Query: 450 ---------GECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCIN 500
CCP C C + C L G G + C TC+C+
Sbjct: 2559 SGFQLSCKTSACCPSCR-----------CERMEACMLNGTVIGPGKTVMIDVCTTCRCMV 2607
Query: 501 TEELCSERKQGC---TLN-CPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKN- 555
+ S K C T N CP G+ + E C +C P C G +
Sbjct: 2608 QVGVISGFKLECRKTTCNPCPLGYKEENNTGECC------GRCLPTACTIQLRGGQIMTL 2661
Query: 556 ------KHGCDICRCK 565
+ GCD CK
Sbjct: 2662 KRDETLQDGCDTHFCK 2677
Score = 71.6 bits (174), Expect = 4e-12
Identities = 162/702 (23%), Positives = 230/702 (32%), Gaps = 189/702 (26%)
Query: 260 CPPVQQTAC-PPDSYETQVRLTADGCCTLPTRCECLSGLCGFP--------------VCE 304
C P+ + C PDS QV L LP EC L VCE
Sbjct: 2123 CQPILEEQCLVPDSSHCQVLL-------LPLFAECHKVLAPATFYAICQQDSCHQEQVCE 2175
Query: 305 VGSTPRIVSRGDGTPGKCCDVFE---CVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQG 361
V ++ + R T G C D C P+ V+N+ E+ C C G
Sbjct: 2176 VIASYAHLCR---TNGVCVDWRTPDFCAMSCPPSLVYNHCEH---------GCPR-HCDG 2222
Query: 362 GVAICFTAQCGEINCERYYVP------EGECCPVCEDPVYPFNNPAGCYANGLILAHGDR 415
V+ CG+ E + P EG C P E+ G L +
Sbjct: 2223 NVS-----SCGDHPSEGCFCPPDKVMLEGSCVP--EEACTQCIGEDGVQHQFL-----EA 2270
Query: 416 WREDD--CTFCQCVNGER-HCVATVC----GQTC-----TNPVKVPGECCP----VCEEP 459
W D C C C++G + +C C TC + +CCP VC+
Sbjct: 2271 WVPDHQPCQICTCLSGRKVNCTTQPCPTAKAPTCGLCEVARLRQNADQCCPEYECVCDPV 2330
Query: 460 TIITVDPPACGELSNCTLTGK-DCINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCP- 517
+ P C TLT +C F TC C +E C K+ +CP
Sbjct: 2331 SCDLPPVPHCERGLQPTLTNPGECRPNF--------TCAC--RKEEC---KRVSPPSCPP 2377
Query: 518 --FGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLK----NKHGCDICRCKKCPELS 571
L Q C+ EC C + CPLG L N GC C P+
Sbjct: 2378 HRLPTLRKTQCCDEYECA-----CNCVNSTVSCPLGYLASTATNDCGCTTTTC--LPDKV 2430
Query: 572 C---SKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRE 628
C S I P+G Q GC +C C + A + C +++ D CR
Sbjct: 2431 CVHRSTIYPVG-QFWEEGCDVCTCTDME-DAVMGLRVAQC---------SQKPCEDSCRS 2479
Query: 629 CYCLNGREMCALITCPVPACGNPTIHPGQCCPSC---ADDFVVQKPELSTPSICHAPGGE 685
+ +H G+CC C A + V P + S + G +
Sbjct: 2480 GFTY-------------------VLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQ 2520
Query: 686 YFVEGETWNIDSCTQCT----CHSGRVLC---ETEVCPP---LLCQNPSRTQDSCCPQCT 735
+ I+ C + V C E VCP L C+ +CCP C
Sbjct: 2521 WASPENPCLINECVRVKEEVFIQQRNVSCPQLEVPVCPSGFQLSCKT-----SACCPSCR 2575
Query: 736 DQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICI--DSVISCFSESCPSVS 793
+ + G + ++ DVCT+C C+ VIS F C +
Sbjct: 2576 CERMEACMLN------------GTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTT 2623
Query: 794 CERPVL------RKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDL--DSCTHCYCL-- 843
C L G+CC C +P G +R + D C +C
Sbjct: 2624 CNPCPLGYKEENNTGECCGRC----LPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVN 2679
Query: 844 -QGQTLCS--TVSCPPL---PCV----EPINVEGSCCPMCPE 875
+G+ CPP C+ + + + G+CC C E
Sbjct: 2680 ERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEE 2721
Score = 49.3 bits (116), Expect = 2e-05
Identities = 90/386 (23%), Positives = 124/386 (32%), Gaps = 109/386 (28%)
Query: 201 GECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGK----PGECCDLYEC---KPVFGV 253
GECC RC+ P+ C P + K+ G P C + EC K +
Sbjct: 2488 GECC---GRCL--PSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFI 2542
Query: 254 DCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSGLCGFPVCEVGSTPRIVS 313
R V CP ++ CP Q+ CC P C
Sbjct: 2543 QQRNVSCPQLEVPVCPSGF---QLSCKTSACC---------------PSCR--------- 2575
Query: 314 RGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRC--QGGVAICFTAQC 371
C+ E AC+ N G +D C CRC Q GV F +C
Sbjct: 2576 ---------CERME-------ACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLEC 2619
Query: 372 GEINCERY---YVPE---GECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDDCT--F 423
+ C Y E GECC C G ++ D +D C F
Sbjct: 2620 RKTTCNPCPLGYKEENNTGECCGRCLPTACTIQLRGG----QIMTLKRDETLQDGCDTHF 2675
Query: 424 CQC-VNGERHCVATVCG------QTCTNP----VKVPGECCPVCEEP------------- 459
C+ GE V G C +K+PG CC CEEP
Sbjct: 2676 CKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECNDITARLQYVK 2735
Query: 460 -----TIITVDPPAC-GELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELCSERKQGCT 513
+ + VD C G+ ++ + D IN + + C C TE +
Sbjct: 2736 VGSCKSEVEVDIHYCQGKCASKAMYSID-INDVQ---DQCSCCSPTRTEPM------QVA 2785
Query: 514 LNCPFGFLTDAQNCEICECRPRPKKC 539
L+C G + + EC+ P+KC
Sbjct: 2786 LHCTNGSVVYHEVLNAMECKCSPRKC 2811
Score = 39.3 bits (90), Expect = 0.019
Identities = 37/153 (24%), Positives = 60/153 (39%), Gaps = 25/153 (16%)
Query: 433 CVATVC----GQTCTNPVKVPGECCPVCEEPTIIT---VDPPACGELSNCTLTGKDCING 485
C T+C G C P + E C + ++ D AC + + + C++
Sbjct: 250 CEKTLCECAGGLECACPALL--EYARTCAQEGMVLYGWTDHSACSPVCPAGMEYRQCVSP 307
Query: 486 FKRDHNGCRTCQCINTEELCSER-KQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIIC 544
RTCQ ++ E+C ER GC +CP G L D C +C +
Sbjct: 308 C------ARTCQSLHINEMCQERCVDGC--SCPEGQLLDEGLC------VESTECPCVHS 353
Query: 545 DKYCPLGLLKNKHGCDICRCKKCPELSCSKICP 577
K P G ++ C+ C C+ + ++ CP
Sbjct: 354 GKRYPPGTSLSR-DCNTCICRNSQWICSNEECP 385
Score = 38.5 bits (88), Expect = 0.033
Identities = 57/257 (22%), Positives = 86/257 (33%), Gaps = 69/257 (26%)
Query: 370 QCGEINCERYYVP-------EGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDDCT 422
+C E E + P G+C P + P CY +G I D + D T
Sbjct: 678 ECNEACLEGCFCPPGLYMDERGDCVPKAQCP---------CYYDGEIFQPEDIF-SDHHT 727
Query: 423 FCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDC 482
C C +G HC T+ G VPG P D
Sbjct: 728 MCYCEDGFMHC--TMSG--------VPGSLLP--------------------------DA 751
Query: 483 INGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICE-CRPRPKKCRP 541
+ H R+ C R L CP L A+ E + C+ +C
Sbjct: 752 VLSSPLSHRSKRSLSC---------RPPMVKLVCPADNLR-AEGLECTKTCQNYDLECMS 801
Query: 542 IICDK--YCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASA 599
+ C CP G++++++ C ++CP K G + GC C CR+ +
Sbjct: 802 MGCVSGCLCPPGMVRHENRC--VALERCPCFHQGKEYAPG-ETVKIGCNTCVCRDRKWNC 858
Query: 600 GPPILSGTCLTVDGHHH 616
+ TC T+ H+
Sbjct: 859 TDHVCDATCSTIGMAHY 875
Score = 32.7 bits (73), Expect = 1.8
Identities = 59/263 (22%), Positives = 93/263 (35%), Gaps = 64/263 (24%)
Query: 544 CDKYCPLGLLKNKHG--CDI-CRCKKCPELSCSK------ICPLGFQQDSHGCLICKCRE 594
C+ CP G + + G C++ CR P+ C++ CP G D G + K +
Sbjct: 648 CELNCPKGQVYLQCGTPCNLTCRSLSYPDEECNEACLEGCFCPPGLYMDERGDCVPKAQ- 706
Query: 595 ASASAGPPILSGTC-LTVDGHHHKNEESWHDGCRECYCLNGREMCAL-----ITCPVPAC 648
C DG + E+ + D CYC +G C + P
Sbjct: 707 -------------CPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCTMSGVPGSLLPDAVL 753
Query: 649 GNPTIHPGQCCPSCADDFVVQKPELSTPS-ICHAPGGEYFVEGETWNIDSCTQCTCHSGR 707
+P H + SC V +L P+ A G E + ++++ C C SG
Sbjct: 754 SSPLSHRSKRSLSCRPPMV----KLVCPADNLRAEGLECTKTCQNYDLE-CMSMGCVSG- 807
Query: 708 VLCETEVCPPLLCQNPSR-TQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAES 766
C +CPP + ++ +R CP C Q G + E+
Sbjct: 808 --C---LCPPGMVRHENRCVALERCP-CFHQ--------------------GKEYAPGET 841
Query: 767 WKPDVCTSCICIDSVISCFSESC 789
K C +C+C D +C C
Sbjct: 842 VKIG-CNTCVCRDRKWNCTDHVC 863
Score = 32.0 bits (71), Expect = 3.1
Identities = 23/68 (33%), Positives = 28/68 (41%), Gaps = 12/68 (17%)
Query: 788 SCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQT 847
SCP E +L +G C+E T + C SGK Y D C C C Q
Sbjct: 330 SCP----EGQLLDEG----LCVEST---ECPCVHSGKRYPPGTSLSRD-CNTCICRNSQW 377
Query: 848 LCSTVSCP 855
+CS CP
Sbjct: 378 ICSNEECP 385
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 80.5 bits (197), Expect = 8e-15
Identities = 198/875 (22%), Positives = 280/875 (32%), Gaps = 239/875 (27%)
Query: 124 PCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCEVQF 183
PCNE N +NGK C TC + + P+ ++ +CS +
Sbjct: 380 PCNEGSNCDTNPVNGKAIC----TCPSGYTGPA----------CSQDVDECSLGANPCEH 425
Query: 184 SPRCPE-----DSVLIEGYAPPGECCPLPSRCVCNP----AGCLRKVCQPGNLNILVSKA 234
+ +C + ++GY P C + CV NP A CL ++ G +
Sbjct: 426 AGKCINTLGSFECQCLQGYTGP-RCEIDVNECVSNPCQNDATCLDQI---GEFQCI---- 477
Query: 235 SGKPGECCDLYECKPVFGVDC--RTVEC---PPVQQTACPPDSYETQVRLTADGCCTLPT 289
C YE GV C T EC P + C E Q
Sbjct: 478 ------CMPGYE-----GVHCEVNTDECASSPCLHNGRCLDKINEFQ------------- 513
Query: 290 RCECLSG----LCGFPVCEVGSTPRIVSRGDGTPGKCCD---VFECVNDTKPACVFNNVE 342
CEC +G LC + V E STP G KC D + CV V+
Sbjct: 514 -CECPTGFTGHLCQYDVDECASTP--CKNG----AKCLDGPNTYTCVCTEGYTGTHCEVD 566
Query: 343 YYDGDMFRMDNCRFCRCQGGVAICFTAQCGE----INCERYYVPEGECCP-------VCE 391
+ D D C + C+ GVA FT C +CE EC C+
Sbjct: 567 IDECD---PDPCHYGSCKDGVA-TFTCLCRPGYTGHHCETNI---NECSSQPCRHGGTCQ 619
Query: 392 DPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGE 451
D +N C+ DDC C +G C+ + G C G
Sbjct: 620 DR----DNAYLCFCLKGTTGPNCEINLDDCASSPCDSGT--CLDKIDGYECACEPGYTGS 673
Query: 452 CCPV---------------CEEPTIITV--------DPPACGELSNCTLTG------KDC 482
C + CE+ DP E++ C +D
Sbjct: 674 MCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDS 733
Query: 483 INGFKRD-------------HNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCE- 528
+NG+K D +N C + C+N C + G C GF NC+
Sbjct: 734 LNGYKCDCDPGWSGTNCDINNNECESNPCVN-GGTCKDMTSGYVCTCREGF--SGPNCQT 790
Query: 529 -ICECRPRP----KKCRPIICDKYCPLGLLKNKHGCDI---------CR----CKKCPEL 570
I EC P C + C L C++ CR C++ +
Sbjct: 791 NINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDY 850
Query: 571 -SCSKICPLGFQ-----QDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHD 624
S S +CP G+Q D + C++ CR AS C G+ +N E+ D
Sbjct: 851 ESFSCVCPTGWQGQTCEVDINECVLSPCRH-GASCQNTHGGYRCHCQAGYSGRNCETDID 909
Query: 625 GCRECYCLNGREM-----CALITC-----------PVPACGNPTIHPGQCCPSCADDFVV 668
CR C NG A C + C + G C C D +
Sbjct: 910 DCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYT- 968
Query: 669 QKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCE-----TEVCPP----LL 719
C P G + E N CT+ +C +G + T +CPP
Sbjct: 969 ----------CTCPAGFSGIHCEN-NTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSY 1017
Query: 720 CQNPSRTQDS--CCPQCTDQ----PFRPSLSRNNSVPNYCKN-----DEGDIFLAAESWK 768
CQ+ DS C T Q +R + + + PN C+N D + W+
Sbjct: 1018 CQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPN-CQNLVHWCDSSPCKNGGKCWQ 1076
Query: 769 PDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYAD 828
C C + + PSVSCE R+G + +C G
Sbjct: 1077 THTQYRCECPSGWTGLYCD-VPSVSCEVAAQRQG----------VDVARLCQHGGLCV-- 1123
Query: 829 EERWDLDSCTHCYCLQGQT--LCSTV--SCPPLPC 859
D + HC C G T C + C P PC
Sbjct: 1124 ----DAGNTHHCRCQAGYTGSYCEDLVDECSPSPC 1154
Score = 42.4 bits (98), Expect = 0.002
Identities = 219/1001 (21%), Positives = 314/1001 (31%), Gaps = 284/1001 (28%)
Query: 40 CDESKCEEPRNCPGSIVQGVCGCCY-----TCASQRNESCGGTFGIYGTCD---RGLRCV 91
C + C C I C C TC S+ NE C ++G C G +C
Sbjct: 682 CAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNE-CNSNPCVHGACRDSLNGYKCD 740
Query: 92 IRPPLNGDSL----TEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRT 147
P +G + E E+ C + D G+ +G N C+ N
Sbjct: 741 CDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPN-----CQTNINEC 795
Query: 148 CSNPFEFPSQDMCLSALKRIEEEKPDC----SKARCEVQFSPRCP------------EDS 191
SNP +Q C+ + K +C + A CEV +P P ED
Sbjct: 796 ASNPCL--NQGTCIDD---VAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDY 850
Query: 192 VLIEGYAPPG---ECCPLP-SRCVCNPAGCLRKV-CQPGNLNILVSKASGKPGECC--DL 244
P G + C + + CV +P C CQ + +G G C D+
Sbjct: 851 ESFSCVCPTGWQGQTCEVDINECVLSP--CRHGASCQNTHGGYRCHCQAGYSGRNCETDI 908
Query: 245 YECKP---------VFGVDCRTVEC-PPVQQTACPPDSYETQVRLTADGC---------- 284
+C+P G++ +C P + T C D E +G
Sbjct: 909 DDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYT 968
Query: 285 CTLPT-----RCE----------------CLSGLCGFP-VCEVGSTPRI----VSRGDGT 318
CT P CE C+ G+ F +C G T V+ D
Sbjct: 969 CTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQ 1028
Query: 319 P----GKC---CDVFECV---NDTKPACVFNNVEYYD-------GDMFRMDNCRFCRCQG 361
P G C C + C T P C N V + D G ++ C C
Sbjct: 1029 PCLHGGTCQDGCGSYRCTCPQGYTGPNCQ-NLVHWCDSSPCKNGGKCWQTHTQYRCECPS 1087
Query: 362 GVAICF----TAQCGEINCERYYVPEGECCP---VCEDPVYPFN-----NPAGCYANGLI 409
G + + C E+ +R V C +C D + G Y L+
Sbjct: 1088 GWTGLYCDVPSVSC-EVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLV 1146
Query: 410 LAHGDRWREDDCTFCQCVNGER----------HCVATVCGQTCT--------NPVKVPGE 451
D+C+ C NG CVA G C+ +P + G
Sbjct: 1147 ---------DECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGT 1197
Query: 452 CCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELCSERKQG 511
C + P P + +C + DC R+ +C N C ++ G
Sbjct: 1198 CLDL---PNTYKCSCPRGTQGVHCEINVDDCNPPVDPVS---RSPKCFNNGT-CVDQVGG 1250
Query: 512 CTLNCPFGFLTDAQNCEICECRPRP------KKCRPIICDKYCPLGLLKNKHGCDI---- 561
+ CP GF+ + ++ EC P + C + D +C C+
Sbjct: 1251 YSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVING 1310
Query: 562 CRCKKCPELSCSKI-----------CPLGF-----QQDSHGCLICKCREASASAGPPILS 605
C+ K C + CP GF + D+ C +C +
Sbjct: 1311 CKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRC----------LNG 1360
Query: 606 GTCLTVDGHHHKNEESWHDGCRE--CYCL---NGREMCALITCPVPAC-----GNPTIHP 655
GTC++ G R C CL G E C PA GNP +
Sbjct: 1361 GTCIS--------------GPRSPTCLCLGPFTGPE------CQFPASSPCLGGNPCYNQ 1400
Query: 656 GQCCPSCADDFV-VQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEV 714
G C P+ F P +CH +Y G +GR ++
Sbjct: 1401 GTCEPTSESPFYRCLCPAKFNGLLCHIL--DYSFGG-------------GAGR-----DI 1440
Query: 715 CPPLL---CQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFL-AAESWKPD 770
PPL+ C+ P +D+ C SL NN + C D GD L + WK
Sbjct: 1441 PPPLIEEACELPECQEDAGNKVC-------SLQCNN---HACGWDGGDCSLNFNDPWKN- 1489
Query: 771 VCTSCICIDSVIS-------CFSESC--PSVSCERPVLRKGQCCP----YCIEDTIPKKV 817
CT + S C S C C+R +GQC P YC +
Sbjct: 1490 -CTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQR---AEGQCNPLYDQYCKDHFSDG-- 1543
Query: 818 VCHFSGKAYADEERWD-LDSCTHC-YCLQGQTLCSTVSCPP 856
H + E WD LD H L TL V PP
Sbjct: 1544 --HCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPP 1582
Score = 37.0 bits (84), Expect = 0.096
Identities = 102/511 (19%), Positives = 147/511 (28%), Gaps = 126/511 (24%)
Query: 419 DDCTFCQCVNGER----------HCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPA 468
D C C NG + HC + G TC V G+ +C + +
Sbjct: 142 DPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGS 201
Query: 469 CGELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCE 528
+ T TG +C +R + C C N G T P G +T
Sbjct: 202 YRCVCRATHTGPNC----ERPYVPCSPSPCQN----------GGTCR-PTGDVTHE---- 242
Query: 529 ICECRP--RPKKCRPIICDKYCPLGLLKNKHGC----DICRCKKCPELSCSKICPLGFQQ 582
C C P + C I D CP KN C + C+ CP + C +
Sbjct: 243 -CACLPGFTGQNCEENIDD--CPGNNCKNGGACVDGVNTYNCR-CPPEWTGQYCTEDVDE 298
Query: 583 DSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNG--REMCAL 640
C+ + G GTC G ++ C C+NG E C+
Sbjct: 299 -------CQLMPNACQNG-----GTCHNTHGGYN------------CVCVNGWTGEDCSE 334
Query: 641 ITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQ 700
+ C + G C F + P T +CH D+C
Sbjct: 335 ---NIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLN-------------DACIS 378
Query: 701 CTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPF--------------------- 739
C+ G V +C PS C Q D+
Sbjct: 379 NPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFEC 438
Query: 740 ---------RPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCP 790
R + N V N C+ND + E CIC+ E
Sbjct: 439 QCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGE-------FQCICMPGYEGVHCEVNT 491
Query: 791 SVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCS 850
P L G+C E + F+G ++D+D C C G
Sbjct: 492 DECASSPCLHNGRCLDKINE--FQCECPTGFTGHLC----QYDVDECASTPCKNGAKCLD 545
Query: 851 TVSCPPLPCVEPINVEGSCCPMCPEMYVPEP 881
+ C E G+ C + + P+P
Sbjct: 546 GPNTYTCVCTE--GYTGTHCEVDIDECDPDP 574
Score = 33.5 bits (75), Expect = 1.1
Identities = 102/482 (21%), Positives = 141/482 (29%), Gaps = 169/482 (35%)
Query: 475 CTLTGKDCINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRP 534
C+ G+ C+NG K C+ N E C C F+ C+
Sbjct: 24 CSQPGETCLNGGK--------CEAANGTEACV---------CGGAFV--GPRCQ------ 58
Query: 535 RPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQD------SHGCL 588
P C C KN C + + + +CS C LGF + CL
Sbjct: 59 DPNPCLSTPC---------KNAGTCHVVDRRGVADYACS--CALGFSGPLCLTPLDNACL 107
Query: 589 ICKCREASASAGPPILSGTC--LTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVP 646
CR GTC LT+ + + W + C + P
Sbjct: 108 TNPCRNG----------GTCDLLTLTEYKCRCPPGWSG--KSCQQAD------------P 143
Query: 647 ACGNPTIHPGQCC----------------PSCADDF--VVQKPELST-PSICHAPGGEY- 686
NP + GQC P+C D QKP L CH G Y
Sbjct: 144 CASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYR 203
Query: 687 FVEGETWNIDSCT-------------------------QCTCHSGRV--LCETEV--CPP 717
V T +C +C C G CE + CP
Sbjct: 204 CVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPG 263
Query: 718 LLCQNPSRTQDS-------CCPQCTDQPFRPSLSRNNSVPNYCKN-------DEGDIFLA 763
C+N D C P+ T Q + +PN C+N G +
Sbjct: 264 NNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVC 323
Query: 764 AESWKPDVCTSCICIDSVISCF-----SESCPSVSCERPVLRKGQCC------------- 805
W + C+ I + +CF + S CE P R G C
Sbjct: 324 VNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNE 383
Query: 806 -PYCIEDTIPKKVVC----HFSGKAYA---DEERWDLDSCTH------------CYCLQG 845
C + + K +C ++G A + DE + C H C CLQG
Sbjct: 384 GSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQG 443
Query: 846 QT 847
T
Sbjct: 444 YT 445
>gi|38348414 von Willebrand factor C domain containing 2 [Homo
sapiens]
Length = 325
Score = 79.0 bits (193), Expect = 2e-14
Identities = 44/153 (28%), Positives = 65/153 (42%), Gaps = 13/153 (8%)
Query: 727 QDSCCPQCTDQPFRPSLSRNNSVPNY----CKNDEGDIFLAAESWKPDVCTS-CICIDSV 781
QD+ P+ P P P+Y C ++ G ++ E + P C+C +
Sbjct: 128 QDAIGPELAPTPEPPE---EYVYPDYRGKGCVDESGFVYAIGEKFAPGPSACPCLCTEEG 184
Query: 782 ISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCY 841
C CP + + QCCP C E +K C F GK Y E + + C C
Sbjct: 185 PLCAQPECPRLHPRCIHVDTSQCCPQCKE----RKNYCEFRGKTYQTLEEFVVSPCERCR 240
Query: 842 C-LQGQTLCSTVSCPPLPCVEPINVEGSCCPMC 873
C G+ LC+ +CP CV+P+ CCP+C
Sbjct: 241 CEANGEVLCTVSACPQTECVDPVYEPDQCCPIC 273
Score = 65.1 bits (157), Expect = 3e-10
Identities = 42/146 (28%), Positives = 64/146 (43%), Gaps = 15/146 (10%)
Query: 288 PTRCECLSGLCGFPVCEVGSTPRIVSRGDGTP-GKCCDVFECVNDTKPACVFNNVEYYDG 346
P+ C CL G P+C PR+ R +CC +C + K C F Y
Sbjct: 173 PSACPCLCTEEG-PLCAQPECPRLHPRCIHVDTSQCCP--QC-KERKNYCEFRGKTYQTL 228
Query: 347 DMFRMDNCRFCRCQ-GGVAICFTAQCGEINC-ERYYVPEGECCPVCEDPVYPFNNPAGCY 404
+ F + C CRC+ G +C + C + C + Y P+ +CCP+C+ N C+
Sbjct: 229 EEFVVSPCERCRCEANGEVLCTVSACPQTECVDPVYEPD-QCCPICK-------NGPNCF 280
Query: 405 ANGLILAHGDRWREDDCTFCQCVNGE 430
A ++ G + D+CT C C E
Sbjct: 281 AETAVIPAGREVKTDECTICHCTYEE 306
Score = 60.5 bits (145), Expect = 8e-09
Identities = 49/175 (28%), Positives = 64/175 (36%), Gaps = 32/175 (18%)
Query: 608 CLTVDGHHHKNEESWHDGCRECYCLNGRE--MCALITCPV--PACGNPTIHPGQCCPSCA 663
C+ G + E + G C CL E +CA CP P C + + QCCP C
Sbjct: 155 CVDESGFVYAIGEKFAPGPSACPCLCTEEGPLCAQPECPRLHPRCIH--VDTSQCCPQCK 212
Query: 664 DDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHS-GRVLCETEVCPPLLCQN 722
+ + C G Y E + + C +C C + G VLC CP C +
Sbjct: 213 E----------RKNYCEFRGKTYQTL-EEFVVSPCERCRCEANGEVLCTVSACPQTECVD 261
Query: 723 PSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCIC 777
P D CCP C + P N E + A K D CT C C
Sbjct: 262 PVYEPDQCCPICKNGP--------NCFA------ETAVIPAGREVKTDECTICHC 302
Score = 57.4 bits (137), Expect = 7e-08
Identities = 42/160 (26%), Positives = 63/160 (39%), Gaps = 22/160 (13%)
Query: 357 CRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRW 416
C C +C +C ++ +V +CCP C++ C G + +
Sbjct: 178 CLCTEEGPLCAQPECPRLHPRCIHVDTSQCCPQCKE------RKNYCEFRGKTYQTLEEF 231
Query: 417 REDDCTFCQC-VNGERHCVATVCGQT-CTNPVKVPGECCPVCEEPTIITVDPPACGELSN 474
C C+C NGE C + C QT C +PV P +CCP+C+ + P C +
Sbjct: 232 VVSPCERCRCEANGEVLCTVSACPQTECVDPVYEPDQCCPICK-------NGPNCFAETA 284
Query: 475 CTLTGKDCINGFKRDHNGCRTCQCINTEELCS-ERKQGCT 513
G++ K D C C C E ER+ CT
Sbjct: 285 VIPAGRE----VKTDE--CTICHCTYEEGTWRIERQAMCT 318
Score = 52.4 bits (124), Expect = 2e-06
Identities = 47/185 (25%), Positives = 67/185 (36%), Gaps = 43/185 (23%)
Query: 534 PRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCR 593
P P C P +C + PL C + C ++ P D+ C +C+
Sbjct: 171 PGPSAC-PCLCTEEGPL----------------CAQPECPRLHPRCIHVDTSQCCP-QCK 212
Query: 594 EASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYC-LNGREMCALITCPVPACGNPT 652
E C + EE C C C NG +C + CP C +P
Sbjct: 213 ERK---------NYCEFRGKTYQTLEEFVVSPCERCRCEANGEVLCTVSACPQTECVDPV 263
Query: 653 IHPGQCCPSC-------ADDFVV---QKPELSTPSICHAPGGEYFVEGETWNIDSCTQCT 702
P QCCP C A+ V+ ++ + +ICH + EG TW I+ CT
Sbjct: 264 YEPDQCCPICKNGPNCFAETAVIPAGREVKTDECTICHCT----YEEG-TWRIERQAMCT 318
Query: 703 CHSGR 707
H R
Sbjct: 319 RHECR 323
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 70.9 bits (172), Expect = 6e-12
Identities = 162/681 (23%), Positives = 218/681 (32%), Gaps = 165/681 (24%)
Query: 184 SPRCPEDSVLIEGYAPPGECCPLPSR---CVCNPAGCLRKVCQPGNLNILVSKASGKPGE 240
+P C + S G G C LPSR C+C P G + + CQ L P
Sbjct: 40 APPCLDGSPCANG----GRCTQLPSREAACLC-PPGWVGERCQ------LEDPCHSGPCA 88
Query: 241 CCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSGLCGF 300
+ + V G + CP + PD C+LP CLS C
Sbjct: 89 GRGVCQSSVVAGTARFSCRCP---RGFRGPD-------------CSLPD--PCLSSPCAH 130
Query: 301 PV-CEVGSTPRIV-SRGDGTPGKCC--DVFECVNDTKPACVFNNVEYYDGDMFRMDNCRF 356
C VG R + S G G+ C DV EC + CR
Sbjct: 131 GARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG--------------------EPCR- 169
Query: 357 CRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRW 416
GG C G C+ P G P+CE+P P P+ C G GD
Sbjct: 170 ---HGGT--CLNTP-GSFRCQ---CPAGYTGPLCENPAVPC-APSPCRNGGTCRQSGDLT 219
Query: 417 RE----------------DDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPT 460
+ DDC +C+NG CV V C P + G+ C E+
Sbjct: 220 YDCACLPGFEGQNCEVNVDDCPGHRCLNGGT-CVDGVNTYNCQCPPEWTGQFC--TEDVD 276
Query: 461 IITVDPPACGELSNC--TLTGKD--CINGF-----KRDHNGCRTCQCINTEELCSERKQG 511
+ P AC C TL G C+NG+ ++ + C T C + C +R
Sbjct: 277 ECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFH-GATCHDRVAS 335
Query: 512 CTLNCPFG------FLTDAQNCEICE----CRPRPKKCRPIICDKYCPLGLLKNKHGCDI 561
CP G L DA C C P R I CP G D+
Sbjct: 336 FYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICT---CPPGFTGGACDQDV 392
Query: 562 CRCK----------KCPELSCSKICPLG-------FQQDSHGCLICKCREASASAGPPIL 604
C +C S +C G + D + CL CR A+ I
Sbjct: 393 DECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRN-QATCLDRIG 451
Query: 605 SGTCLTVDGHHHKNEESWHDGCRECYCLNG-----REMCALITCP-----------VPAC 648
TC+ + G E D C+ C+NG R TCP V C
Sbjct: 452 QFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDEC 511
Query: 649 GNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRV 708
+ G C D + + E ++C N+D C+ CH GR
Sbjct: 512 ASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDR------------NVDDCSPDPCHHGR- 558
Query: 709 LCETEVCPPLLCQNPSRTQDSC---CPQCTDQPFRPSLSRNNSVPNY-CKNDEGDIFLAA 764
C + P T C +C QP R + V Y C+ G +
Sbjct: 559 -CVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNC 617
Query: 765 E----SWKPDVCTSCICIDSV 781
E + CT +C D +
Sbjct: 618 EVNIDDCASNPCTFGVCRDGI 638
Score = 49.7 bits (117), Expect = 1e-05
Identities = 174/767 (22%), Positives = 239/767 (31%), Gaps = 234/767 (30%)
Query: 124 PCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCEVQF 183
PC+E+ I N +NG+ C TC F + D ++ +CS +
Sbjct: 359 PCHEDAICDTNPVNGRAIC----TCPPGFTGGACD----------QDVDECSIGANPCEH 404
Query: 184 SPRC--PEDSVLIE---GYAPP------GECCPLPSRCVCNPAGCLRKVCQPGNLNILVS 232
RC + S L + GY P EC P R N A CL ++ Q
Sbjct: 405 LGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCR---NQATCLDRIGQ-----FTCI 456
Query: 233 KASGKPGECC--DLYECKP---VFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTL 287
+G G C D+ EC+ V G C+ + CP + +L D C +
Sbjct: 457 CMAGFTGTYCEVDIDECQSSPCVNGGVCK--DRVNGFSCTCPSGFSGSTCQLDVDECAST 514
Query: 288 PTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFE---C---VNDTKPACVFNNV 341
P R + + V + DG +C + FE C V+D P
Sbjct: 515 PCR----------------NGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSP------- 551
Query: 342 EYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPA 401
D C RC G+A F+ C G CE V
Sbjct: 552 ----------DPCHHGRCVDGIA-SFSCACA----------PGYTGTRCESQV------- 583
Query: 402 GCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTI 461
D+C C +G + C+ V C P G C V
Sbjct: 584 -----------------DECRSQPCRHGGK-CLDLVDKYLCRCPSGTTGVNCEV------ 619
Query: 462 ITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCIN--TEELCSERKQGCTLN-C-P 517
+ +C C G RD C C T LC+ C + C
Sbjct: 620 ---------NIDDC--ASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGE 668
Query: 518 FGFLTDAQNCEICECRP--RPKKCRP---IICDKYCPLGLLKNKHGCDICRCKKCPELSC 572
G D +N C C P P C P + C G+ + G C C+ P S
Sbjct: 669 GGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCE--PGWSG 726
Query: 573 SKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYC- 631
+ C +D+ C AG GTC + H C C
Sbjct: 727 PR-CSQSLARDA-------CESQPCRAG-----GTCSSDGMGFH------------CTCP 761
Query: 632 --LNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVE 689
+ GR+ C L++ P NP H G+C + Q P S P P + V+
Sbjct: 762 PGVQGRQ-CELLS---PCTPNPCEHGGRC-----ESAPGQLPVCSCPQGWQGPRCQQDVD 812
Query: 690 -----------GETWNIDSCTQCTCHSGRV--LCETEV--CPPLLCQNPSRTQD------ 728
G N+ CTCH G C+ ++ C P C N QD
Sbjct: 813 ECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFS 872
Query: 729 -SCCP------------QCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVC-TS 774
SC P +C P P ++ C G E PD +S
Sbjct: 873 CSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSS 932
Query: 775 CI----CIDSVIS-------------CFSESCPSVSCERPVLRKGQC 804
C C+D V S C E+ P +S RP L G C
Sbjct: 933 CFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLS--RPCLHGGVC 977
Score = 42.7 bits (99), Expect = 0.002
Identities = 142/636 (22%), Positives = 194/636 (30%), Gaps = 135/636 (21%)
Query: 182 QFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGEC 241
+FS RCP G+ P C LP C+ +P + + L S G G
Sbjct: 103 RFSCRCPR------GFRGPD--CSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRS 154
Query: 242 C--DLYECKPVFGVDCR----TVECPPVQQTACPPDSYETQVRLTADGCCTLPTR----- 290
C D+ EC+ G CR + P + CP A C P R
Sbjct: 155 CRSDVDECR--VGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTC 212
Query: 291 ---------CECLSGLCGFPVCEVGSTP----RIVSRG---DGTPGKCCDVFE------C 328
C CL G G CEV R ++ G DG C C
Sbjct: 213 RQSGDLTYDCACLPGFEG-QNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFC 271
Query: 329 VNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCP 388
D + N + G F C C G +T + N +
Sbjct: 272 TEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNG----WTGESCSQNIDDCATAVCFHGA 327
Query: 389 VCEDPVYPFNNPAGCYANGLILAHGDRWREDDC---TFCQC--VNGERHCVAT------V 437
C D V F GL+ D + C C VNG C
Sbjct: 328 TCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGA 387
Query: 438 CGQTC------TNPVKVPGECC----------------PVCEEPTIITVDPPACGELSNC 475
C Q NP + G C P CE + P + +
Sbjct: 388 CDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCL 447
Query: 476 TLTGKD---CINGF-----KRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNC 527
G+ C+ GF + D + C++ C+N +C +R G + CP GF
Sbjct: 448 DRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGG-VCKDRVNGFSCTCPSGFSGSTCQL 506
Query: 528 EICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGC 587
++ EC P + D+ P G CRC + E +C ++ C
Sbjct: 507 DVDECASTPCRNGAKCVDQ--PDGY--------ECRCAEGFE---GTLC----DRNVDDC 549
Query: 588 LICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPA 647
C G I S +C G+ ES D CR C +G + L+ +
Sbjct: 550 SPDPCHHGRCVDG--IASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCR 607
Query: 648 CGNPTIHPGQCCPSCADD-------FVVQKPELSTPSICHAPGGEYFVEGETWN--IDSC 698
C P+ G C DD F V + ++ PG G N I+ C
Sbjct: 608 C--PSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPG----FTGPLCNVEINEC 661
Query: 699 TQCTCHSG----------RVLCETEVCPPLLCQNPS 724
C G R LC PP LC PS
Sbjct: 662 ASSPCGEGGSCVDGENGFRCLCPPGSLPP-LCLPPS 696
Score = 40.4 bits (93), Expect = 0.009
Identities = 147/666 (22%), Positives = 200/666 (30%), Gaps = 162/666 (24%)
Query: 140 CECNTIRTCSNPFEFPSQDMCLSALKRIEEE-KPDCSKARCEVQF----SPRCPEDSVLI 194
CE N SNP F +C + R + +P + C V+ S C E +
Sbjct: 617 CEVNIDDCASNPCTF---GVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCV 673
Query: 195 EG------YAPPGE----CCPLPSRCVCNPA---------GCLRKVCQPGNLNILVSKAS 235
+G PPG C P C P G R VC+PG S++
Sbjct: 674 DGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSL 733
Query: 236 GKPGECCDLYECKPVFGVDCRT------VECPPVQQ-------TACPPDSYETQVRL-TA 281
+ + C+ C+ G C + CPP Q + C P+ E R +A
Sbjct: 734 AR--DACESQPCRA--GGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESA 789
Query: 282 DGCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDV---FEC---------- 328
G LP C C G G P C+ G G C ++ F C
Sbjct: 790 PG--QLPV-CSCPQGWQG-PRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPS 845
Query: 329 ----VNDTKPACVFNNVEYYDGDMFRMDNCR--FC--RCQGGVAICFTAQCGEINCERYY 380
+ND P N DG +C F RC V C + CG C +
Sbjct: 846 CDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHV 905
Query: 381 VPEGECCPV------CEDPVYPFNNPAGCYANGLIL----------------AHGDRWRE 418
CP CE + P +P+ C+ G + AH
Sbjct: 906 ASFTCTCPPGYGGFHCEQDL-PDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQH-EA 963
Query: 419 DDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLT 478
D C C++G C A G CT G C + + C C T
Sbjct: 964 DPCLSRPCLHGGV-CSAAHPGFRCTCLESFTGPQC----QTLVDWCSRQPCQNGGRCVQT 1018
Query: 479 GKDCI--NGFKRDHNGCRTCQC--------INTEELCSERKQGCTLN------CPFGFLT 522
G C+ G+ R+ C + E+LC Q + CP G
Sbjct: 1019 GAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTG 1078
Query: 523 DAQNCEICECRPRPKK----CRPIICDKYCPLGLLKNKHGC----DICRCKKCPEL-SCS 573
E+ C +P + CR + C N C D C + C SC
Sbjct: 1079 SHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCI 1138
Query: 574 KICPLGFQQDSHGCL--ICKCREASASAGPPILSG-------TCLTVDGHHHKNEESWHD 624
+ G L +C+ E GPP+ SG TC+ + G +
Sbjct: 1139 DLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYT 1198
Query: 625 GCR-----------------------------ECYCLNGREMCALITCPVPACGNPTIHP 655
G R C C G T P P H
Sbjct: 1199 GLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHG 1258
Query: 656 GQCCPS 661
GQC PS
Sbjct: 1259 GQCRPS 1264
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 70.1 bits (170), Expect = 1e-11
Identities = 164/758 (21%), Positives = 236/758 (31%), Gaps = 154/758 (20%)
Query: 283 GCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVE 342
G CT+P C C G G E P V G C + ++C N E
Sbjct: 254 GGCTVPGECRCSYGWQGRFCDECVPYPGCVH------GSCVEPWQC-----------NCE 296
Query: 343 YYDGDMFRMDNCRFCR----CQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVY--- 395
G + + +C C G C A+ + C P+G CE +
Sbjct: 297 TNWGGLLCDKDLNYCGSHHPCTNG-GTCINAEPDQYRCT---CPDGYSGRNCEKAEHACT 352
Query: 396 --PFNNPAGCYA--NGLILAHGDRWRE-------DDCTFCQCVNGERHCVATVCGQTCTN 444
P N C+ +G W D+C C G CV V G C
Sbjct: 353 SNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGT-CVDQVDGFECIC 411
Query: 445 PVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFK-------------RDHN 491
P + G C + D C T KD +NG++ + +
Sbjct: 412 PEQWVGATCQL---------DVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERD 462
Query: 492 GCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRP----KKCRPIICDKY 547
C + C ++ LC + G +CP GF ++ C P P +C + D Y
Sbjct: 463 ECASSPC-HSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYY 521
Query: 548 CPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGT 607
C C + R + CP +C I GC + AGP +
Sbjct: 522 CACPDDFGGKNCSVPR-EPCPGGACRVI---------DGC--------GSDAGPGMPGTA 563
Query: 608 CLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQC--------- 658
V G H + S G C C +G G P + G C
Sbjct: 564 ASGVCGPHGRCV-SQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC 622
Query: 659 -CPSCAD-DFVVQKPELSTPSICHAPGGEYFVEGETWNI--DSCTQCTCHSGRVLCETEV 714
CPS + + P P CH+ G Y + + + D TCHS C+
Sbjct: 623 FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT 682
Query: 715 CPPL-LCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKND-----EGDIF--LAAES 766
C C + T CP ++ +PN C N G F + +
Sbjct: 683 CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG 742
Query: 767 WKPDVCT----SC---------ICIDSVISCFSESCPSVS----------CERPVLRKGQ 803
W+ CT C IC+D V E P + C+ G
Sbjct: 743 WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA 802
Query: 804 CC-----------------PYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQ 846
C P C ++ I C G + W ++ C C CL G+
Sbjct: 803 TCVDEINGYRCSCPPGRAGPRC-QEVIGFGRSCWSRGTPFPHGSSW-VEDCNSCRCLDGR 860
Query: 847 TLCSTVSCPPLPCVEPINVE--GSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVPLWPT 904
CS V C PC+ E + CP+ P GE E P T
Sbjct: 861 RDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPP-ST 919
Query: 905 PSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIAS 942
P HL + L + + NR H + +++ +I S
Sbjct: 920 PCLPRSGHLDNNCARLTLHF--NRDHVPQGTTVGAICS 955
Score = 39.7 bits (91), Expect = 0.015
Identities = 153/703 (21%), Positives = 222/703 (31%), Gaps = 149/703 (21%)
Query: 123 KPCNENLIA-GCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCEV 181
K C E + GCN+++G C CS ++ D C+ + + + CE
Sbjct: 238 KECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCET 297
Query: 182 QFSP-RCPEDSVLIEGYAP---PGECC---PLPSRCVCNPAGCLRKVCQPGNLNILVSKA 234
+ C +D + P G C P RC C P G + C+
Sbjct: 298 NWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTC-PDGYSGRNCE----------- 345
Query: 235 SGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPTRC--E 292
K C C G C E P + CP L D C + P
Sbjct: 346 --KAEHACTSNPC--ANGGSCH--EVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGT 399
Query: 293 CLSGLCGF----PVCEVGSTPRI---VSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYD 345
C+ + GF P VG+T ++ RG G C + VN + C +
Sbjct: 400 CVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCK--DLVNGYQCVC----PRGFG 453
Query: 346 GDMFRM--DNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPV-----YPFN 398
G + D C C G +C G +C + P+G P+CE V P
Sbjct: 454 GRHCELERDECASSPCHSG-GLCEDLADG-FHC---HCPQGFSGPLCEVDVDLCEPSPCR 508
Query: 399 NPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVK-VPGECCPVCE 457
N A CY GD +C C + G+ C+ P + PG C V +
Sbjct: 509 NGARCYN-----LEGD-------YYCACPD-------DFGGKNCSVPREPCPGGACRVID 549
Query: 458 ------EPTII-TVDPPACGELSNCTLTGKD-----CINGFKRD--HNGCRTC--QCINT 501
P + T CG C C +GF H C Q
Sbjct: 550 GCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRN 609
Query: 502 EELCSERKQGCTLNCPFGFLTDAQNCEICECRPRP----KKCRPIICDKYCPLGLLKNKH 557
C + CP G+ + + +C P P +C ++ D YC
Sbjct: 610 GGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGK 669
Query: 558 GCDICRCKKCPELSCSK-------------ICPLGFQQDSHGCLICKCREASASAGPPIL 604
C R +C +CS CP G++ + C + K +S P +
Sbjct: 670 TCH-SREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGST--CAVAK--NSSCLPNPCVN 724
Query: 605 SGT---------CLTVDGHHHKNEESWHDGCR--ECY----CLNGREMCALITCPVPACG 649
GT C+ DG + + C CY C++G P A
Sbjct: 725 GGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGP 784
Query: 650 NPTIHPGQCCPS-------CADDFVVQK----PELSTPSICHAPG--------GEYFVEG 690
+ I+ +C S C D+ + P + P G G F G
Sbjct: 785 DCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHG 844
Query: 691 ETWNIDSCTQCTCHSGRVLCETEVC---PPLLCQNPSRTQDSC 730
+W ++ C C C GR C C P LL P C
Sbjct: 845 SSW-VEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQC 886
Score = 35.8 bits (81), Expect = 0.21
Identities = 83/368 (22%), Positives = 117/368 (31%), Gaps = 63/368 (17%)
Query: 39 PCDESKCEEPRNC--------PGSIVQGVCGCCYTCASQ--RNESCGGTFGIYGT-CDRG 87
PC C C PG+ GVCG C SQ N SC G GT C
Sbjct: 539 PCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHEN 598
Query: 88 L-RCVIRPPLNGDS-LTEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTI 145
+ C+ +P NG + + E +A C + + +L P N+ L C+ G+C
Sbjct: 599 IDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNP-NDCLPDPCH-SRGRC----- 651
Query: 146 RTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCEVQFSPRCPEDSVLIEGYAPP---GE 202
N F D K + C C C + PP G
Sbjct: 652 YDLVNDFYCACDDGWKG--KTCHSREFQCDAYTC--SNGGTCYDSGDTFRCACPPGWKGS 707
Query: 203 CCPLPSRCVCNPAGCLR-KVCQPGNLNILVSKASGKPGECC--DLYECKP---------V 250
C + C P C+ C + G G C + +C P V
Sbjct: 708 TCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICV 767
Query: 251 FGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPTR--CECLSGLCGFPVCEVGST 308
GV+ EC P PD R+ D C + P C+ + G+
Sbjct: 768 DGVNWFRCECAP---GFAGPD-----CRINIDECQSSPCAYGATCVDEINGY-------- 811
Query: 309 PRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFT 368
R PG+ + V +C + G + +++C CRC G C
Sbjct: 812 -----RCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSW-VEDCNSCRCLDGRRDCSK 865
Query: 369 AQCGEINC 376
CG C
Sbjct: 866 VWCGWKPC 873
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 69.7 bits (169), Expect = 1e-11
Identities = 145/617 (23%), Positives = 200/617 (32%), Gaps = 158/617 (25%)
Query: 147 TCSNPFE--FPSQDMCLSALKRIEEEKPDCSKARCEVQFSPRCPEDSVLIEGYAPPGECC 204
+C+ PF + C + E A+ +F C + EC
Sbjct: 628 SCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECA 687
Query: 205 PLPSRC---VC-NPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVEC 260
P C VC N G R VC G + ASGK +C D+ EC + + C C
Sbjct: 688 LDPEVCANGVCENLRGSYRCVCNLG----YEAGASGK--DCTDVDECA-LNSLLCDNGWC 740
Query: 261 ---PPVQQTACPPDSY---ETQVRLTADGCCTLPTRCECLSGLC----GFPVCEVGSTPR 310
P +CPP + +T++ D C + P C+SG+C G C+ G R
Sbjct: 741 QNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSP----CVSGVCRNLAGSYTCKCGPGSR 796
Query: 311 IVSRG----DGTPGKC--------CDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCR 358
+ G D T G C C+V + C + C C
Sbjct: 797 LDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSP------CERCE 850
Query: 359 ----CQGGVAICFTAQCGEIN-CERY--YVPEGECCPV-----CEDPVYPFNNPAGCYAN 406
C G A C ++N CE + P G C CE P + +G
Sbjct: 851 IDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCV 910
Query: 407 GLILAHGD-RWREDDC----------TFCQCVNGERHCVATVCGQTCTNPVKVPGECCPV 455
+ L RW ED+C C C + V G C E CP
Sbjct: 911 DVRLEPCFLRWDEDECGVTLPGKYRMDVCCC------SIGAVWGVEC--------EACPD 956
Query: 456 CEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELCSERKQGCTLN 515
E ++ P G S L+G+ F +D N C+ + T C
Sbjct: 957 PESLEFASLCPRGLGFASRDFLSGRP----FYKDVNECKVFPGLCTHGTCRNTVGSFHCA 1012
Query: 516 CPFGFLTDAQ--NC-EICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSC 572
C GF DAQ NC +I ECR P C G N G C C
Sbjct: 1013 CAGGFALDAQERNCTDIDECRISP---------DLCGQGTCVNTPGSFECEC-------- 1055
Query: 573 SKICPLGFQQDSHGCLICK-CREASASAGPPIL--SGTCLTVDGHHHKNEESWHDGCREC 629
F G ++ K C + A P+L GTC DG + +C
Sbjct: 1056 -------FPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSY------------KC 1096
Query: 630 YCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVE 689
C G E+ A T +C D + + LS H
Sbjct: 1097 QCPPGHELTAKGT------------------ACED---IDECSLSDGLCPH--------- 1126
Query: 690 GETWNIDSCTQCTCHSG 706
G+ N+ QC+CH+G
Sbjct: 1127 GQCVNVIGAFQCSCHAG 1143
Score = 56.2 bits (134), Expect = 2e-07
Identities = 154/675 (22%), Positives = 210/675 (31%), Gaps = 184/675 (27%)
Query: 201 GECCPLPS--RCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYEC--KPVFGVDCR 256
G C P PS RC CN V GEC D+ EC P DC
Sbjct: 422 GRCLPTPSSYRCECN-----------------VGYTQDVRGECIDVDECTSSPCHHGDC- 463
Query: 257 TVECPPVQQTACPPDSYETQVR---------LTADGCCTLPT--------RCECLSG--- 296
V P C P T R + + G C L +C C +G
Sbjct: 464 -VNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFEL 522
Query: 297 -----------------LCGFPVC--EVGSTPRIVSRGDG-TPGK--CCDVFECVNDTKP 334
+C VC E GS + G PG C D+ EC T
Sbjct: 523 SPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC--QTPG 580
Query: 335 ACVFNNVEYYDGDMFRMDNCRFCRCQGGVAI---------------CFTAQCGEINCERY 379
CV + +G FR C+C GG+A+ C+ A + +C R
Sbjct: 581 ICVNGHCTNTEGS-FR------CQCLGGLAVGTDGRVCVDTHVRSTCYGA-IEKGSCARP 632
Query: 380 Y---VPEGECCPVCEDPVYPFNNPAG-CYANG-----LILAHGDRWREDDCTFCQCVNGE 430
+ V + ECC C +P + F P C A + + G D +C
Sbjct: 633 FPGTVTKSECC--CANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDP 690
Query: 431 RHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDH 490
C VC + G VC C ++ C L C NG+ ++
Sbjct: 691 EVCANGVCEN-------LRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNS 743
Query: 491 NGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNC-EICECRPRPKKCRPIICDKYCP 549
G +C C F F D + C ++ EC P C
Sbjct: 744 PGSYSCSC----------------PPGFHFWQDTEICKDVDECLSSP-----------CV 776
Query: 550 LGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCL 609
G+ +N G C+C L S L + + I + R G + S C
Sbjct: 777 SGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCA 836
Query: 610 TVDGHHHKNEESWHDGCREC----YCLNGREMCALITC-PVPACGN-PTIHPGQCCPSCA 663
T+ +W C C C G +TC V C + P + P C + A
Sbjct: 837 TLGA-------AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTA 889
Query: 664 DDFVVQKPELSTPSICHAPGGEYFVEGE------TWNIDSC----------TQCTCHSGR 707
F + PE + G V+ W+ D C C C G
Sbjct: 890 GSFRCECPE----GLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGA 945
Query: 708 VL-CETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAES 766
V E E CP S S CP+ R LS P Y +E +F
Sbjct: 946 VWGVECEACP----DPESLEFASLCPRGLGFASRDFLSGR---PFYKDVNECKVF----- 993
Query: 767 WKPDVCTSCICIDSV 781
P +CT C ++V
Sbjct: 994 --PGLCTHGTCRNTV 1006
Score = 45.4 bits (106), Expect = 3e-04
Identities = 110/470 (23%), Positives = 150/470 (31%), Gaps = 160/470 (34%)
Query: 196 GYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDC 255
G+ P E CPLP RK+C G SG E D+ EC+ +
Sbjct: 2331 GWGPRCELCPLPG------TSAYRKLCPHG---------SGYTAEGRDVDECRML----- 2370
Query: 256 RTVECPPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSGLCGFPV-CEVGSTPRIVSR 314
L A G EC++ L F C+ G TP
Sbjct: 2371 ---------------------AHLCAHG--------ECINSLGSFRCHCQAGYTP----- 2396
Query: 315 GDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEI 374
D T C D+ EC KP C F C+ G +C
Sbjct: 2397 -DATATTCLDMDECSQVPKP-CTF-----------------LCKNTKGSFLC-------- 2429
Query: 375 NCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCV 434
+C R Y+ E E C+D D+CT Q N + CV
Sbjct: 2430 SCPRGYLLE-EDGRTCKD-------------------------LDECTSRQ-HNCQFLCV 2462
Query: 435 ATVCGQTCTNPVKVPG--ECCPVCEEPTIITVDPPACGELSNCTLTGK----DCINGFKR 488
TV TC P PG + C + + P CG +C T +C GF
Sbjct: 2463 NTVGAFTCRCP---PGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTL 2519
Query: 489 DHNGCRTCQCIN-------TEELCSERKQGCTLNCPFGFLTDAQNCEIC---ECRPRPKK 538
+G C+ +N + C + G +CP GF +Q + EC P
Sbjct: 2520 VSSG-HGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPT 2578
Query: 539 CRPIICDK-------YCPLGLLKNK--HGC---DICRCKKCPELSCSKICPLGFQQDSHG 586
C C CP G ++ GC D C ++ P CS C ++ G
Sbjct: 2579 CGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGP---CSYSC-----ANTPG 2630
Query: 587 CLICKCREASASAGPPILSGTCLTVDGHH-------HKNEESWHDGCREC 629
+C C + AG G C++ G K E + C EC
Sbjct: 2631 GFLCGCPQGYFRAG----QGHCVSGLGFSPGPQDTPDKEELLSSEACYEC 2676
Score = 42.0 bits (97), Expect = 0.003
Identities = 148/645 (22%), Positives = 197/645 (30%), Gaps = 150/645 (23%)
Query: 202 ECCPLPSRCV---C-NPAGCLRKVCQPGNLNILVSKASGKPGECCDLYEC--KPVFGVDC 255
EC L C+ C N G R +C PG + C D+ EC +P +
Sbjct: 1932 ECLSLAGTCLPGTCQNLEGSFRCICPPG--------FQVQSDHCIDIDECSEEPNLCLFG 1983
Query: 256 RTVECPPVQQTACPPD---------SYETQ-----VRLTADGCC------TLPTRCECLS 295
P Q CPP ++T+ R A C T TRC C
Sbjct: 1984 TCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSK 2043
Query: 296 --GLCGFPVCEV------GSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGD 347
G CE+ + + G G D E VN+ C N +G
Sbjct: 2044 RPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNE----CAENPGVCTNGV 2099
Query: 348 MFRMDNCRFCRCQGGVAICFTA-------------QCGEINCERYYVPEGECCPVCEDPV 394
D C C G ++ FT CG+ C + EC C D
Sbjct: 2100 CVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNV-IGGFECA--CADGF 2156
Query: 395 YP-----FNNPAGCYANGLILAH---------------GDRWREDDCTFC----QCVNGE 430
P + C N L+ A G RED C +C +G+
Sbjct: 2157 EPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGA-MCRDVDECADGQ 2215
Query: 431 RHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDH 490
+ C A G C N + CP P + C + + C C+NG +
Sbjct: 2216 QDCHAR--GMECKNLIGTFACVCPPGMRP--LPGSGEGCTDDNECHAQPDLCVNGRCVNT 2271
Query: 491 NGCRTCQCIN------TEELCSERKQG----------C-TLNCPFGFLTDAQNC------ 527
G C C T C + +QG C +L+ +T A+ C
Sbjct: 2272 AGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRG 2331
Query: 528 --EICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSH 585
CE P P K CP G G D+ C+ L C G +S
Sbjct: 2332 WGPRCELCPLPGTSA---YRKLCPHGSGYTAEGRDVDECRMLAHL-----CAHGECINSL 2383
Query: 586 GCLICKCREASASAGPPILSGTCLTVDGHHH---------KNEE-SWHDGCRECYCL--N 633
G C C+ A P + TCL +D KN + S+ C Y L +
Sbjct: 2384 GSFRCHCQ---AGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEED 2440
Query: 634 GREMCALITCPVPA------CGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYF 687
GR L C C N T+ C C F C A G
Sbjct: 2441 GRTCKDLDECTSRQHNCQFLCVN-TVGAFTC--RCPPGFTQHHQACFDNDECSAQPGPCG 2497
Query: 688 VEGETWNIDSCTQCTCHSGRVLCET-EVCPPL-LCQNPSRTQDSC 730
G N +C CH G L + C + C P R Q C
Sbjct: 2498 AHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGC 2542
Score = 39.7 bits (91), Expect = 0.015
Identities = 113/513 (22%), Positives = 161/513 (31%), Gaps = 89/513 (17%)
Query: 239 GECCDLYECKPVFGVDCRTVECPPVQQT--ACPPDSYETQVRLTADG-CCTLPTRCECLS 295
G+C D EC + G CR C + D +E LTADG C C L+
Sbjct: 1882 GDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFE----LTADGKNCVDTNECLSLA 1937
Query: 296 GLCGFPVCE--VGSTPRIVSRG-DGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMD 352
G C C+ GS I G C D+ EC ++ C+F G
Sbjct: 1938 GTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDEC-SEEPNLCLFGTCTNSPGSF---- 1992
Query: 353 NCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAH 412
C C G + N R C D F C+
Sbjct: 1993 ---QCLCPPGFVL-------SDNGHR-----------CFDTRQSF-----CFT------- 2019
Query: 413 GDRWREDDCTFCQCVN--GERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACG 470
R+ C+ + N R C + G+ +P E CP + P G
Sbjct: 2020 --RFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPC----ELCPQEGSAAFQELCPFGHG 2073
Query: 471 ELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTD--AQNC- 527
+ G D + D N C + T +C CPFG+ D NC
Sbjct: 2074 -----AVPGPD---DSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCV 2125
Query: 528 EICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGC 587
+ EC C G N G C C E C + S
Sbjct: 2126 DTDECS----------VGHPCGQGTCTNVIGGFECACADGFEPGLMMTCE-DIDECSLNP 2174
Query: 588 LIC--KCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYC--LNGREMCALITC 643
L+C +C S +G L DG ++ + DG ++C+ + + + C
Sbjct: 2175 LLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFAC 2234
Query: 644 PVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTC 703
P P G+ C D+ +P+L C G + + + S T C
Sbjct: 2235 VCPPGMRPLPGSGEGCTD--DNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTEC 2292
Query: 704 HSGRV-LCETEV----CPPLLCQNPSRTQDSCC 731
H R C EV C L + + T+ CC
Sbjct: 2293 HDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECC 2325
Score = 37.4 bits (85), Expect = 0.074
Identities = 105/513 (20%), Positives = 150/513 (29%), Gaps = 145/513 (28%)
Query: 247 CKPVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPT---RCECLSGL-CGFPV 302
C F +D + C + + PD L G C CEC G GF +
Sbjct: 1013 CAGGFALDAQERNCTDIDECRISPD-------LCGQGTCVNTPGSFECECFPGYESGFML 1065
Query: 303 CEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGG 362
+ C DV EC D + G D C+C G
Sbjct: 1066 MK----------------NCMDVDECARDP--------LLCRGGTCTNTDGSYKCQCPPG 1101
Query: 363 VAICFTAQC----GEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWRE 418
+ E + P G+C V C + + DR
Sbjct: 1102 HELTAKGTACEDIDECSLSDGLCPHGQCVNVI--------GAFQCSCHAGFQSTPDRQGC 1153
Query: 419 DDCTFCQCVNG--ERHCVATV------CGQT---------------------------CT 443
D C+ NG + HC+ T CGQ CT
Sbjct: 1154 VDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCT 1213
Query: 444 NPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTEE 503
N +PG +C + + T D C ++ C L C++G + G C C +
Sbjct: 1214 N---MPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHC----Q 1266
Query: 504 LCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDI-C 562
L ++G T C +D CE+ H CD
Sbjct: 1267 LGYMVRKGAT-GC-----SDVDECEV-------------------------GGHNCDSHA 1295
Query: 563 RCKKCP-ELSCSKICPLGFQQDSHGCL-ICKCREASASAGPPILSGTCLTVDGHHHKNEE 620
C P SC C G+ D C + +C P G CL V G
Sbjct: 1296 SCLNIPGSFSCR--CLPGWVGDGFECHDLDECVSQEHRCSP---RGDCLNVPG------- 1343
Query: 621 SWHDGCRECYCLNG-----REMCA--LITCPVPACGNPTIHPGQCCPSCADDFVVQKPEL 673
S+ CR+ + +G R+ CA + C C N PG C F +
Sbjct: 1344 SYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNA---PGGYRCECEMGFDPTEDHR 1400
Query: 674 STPSICHAPGGEYFVEGETWNIDSCTQCTCHSG 706
+ + G G N+ +C C+ G
Sbjct: 1401 ACQDVDECAQGNLCAFGSCENLPGMFRCICNGG 1433
Score = 35.8 bits (81), Expect = 0.21
Identities = 138/653 (21%), Positives = 189/653 (28%), Gaps = 222/653 (33%)
Query: 278 RLTADGCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACV 337
R +G C+ P C C G P C VSRG G C V C+N
Sbjct: 88 RACGEGFCSQPNLCTCADGTLA-PSCG-------VSRGSG-----CSV-SCMNG------ 127
Query: 338 FNNVEYYDGDMFRMDNCR--FCRCQGGVAICFTAQCGEINCERYYVPEGECC-PVCEDPV 394
CR C CQ G CG+ C+R G C P V
Sbjct: 128 --------------GTCRGASCLCQKGYT---GTVCGQPICDRGCHNGGRCIGPNRCACV 170
Query: 395 YPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERH------CVATVCGQTCTNPVKV 448
Y F P C + +R C G +H C +C T +
Sbjct: 171 YGFMGPQ-CERD---------YRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGL 220
Query: 449 PGECCPV----CEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQC------ 498
P E CP C I + AC ++ C C G + G C+C
Sbjct: 221 PCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRL 280
Query: 499 INTEELCSERKQGCTLNCPF---------GFLTDAQNC----EICECRPRPKKCRP---- 541
++ C + + G + F G T Q C P P+ C P
Sbjct: 281 SDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSN 340
Query: 542 ---IICDKYCPL---------GLL---------------KNKHG---------------- 558
+C + PL GLL N HG
Sbjct: 341 EFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNI 400
Query: 559 --------CDIC----------RCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAG 600
DIC RC P S C +G+ QD G +C +
Sbjct: 401 GTATLNQTIDICRHFTNLCLNGRCLPTPS-SYRCECNVGYTQDVRG----ECIDVDECTS 455
Query: 601 PPILSGTCLTVDGHHHKNEESWHDGCRECYCLNG------REMCALITCPVPACGNPTIH 654
P G C+ + G +H C C G R+ C + + + G H
Sbjct: 456 SPCHHGDCVNIPGTYH------------CRCYPGFQATPTRQACVDVDECIVSGG--LCH 501
Query: 655 PGQCCPS-------CADDF--------VVQKPELSTPSICHAPGGEYFVEGETWNIDSCT 699
G+C + C F V E +T ++C V G N D
Sbjct: 502 LGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMC--------VNGVCLNEDGSF 553
Query: 700 QCTCHSGRVLCE-TEVCPPL-LCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDE 757
C C G +L C + CQ P C V +C N E
Sbjct: 554 SCLCKPGFLLAPGGHYCMDIDECQTP-----GIC-----------------VNGHCTNTE 591
Query: 758 GDIFLAAESWKPDVCTSCICIDSVI--SCFSESCPSVSCERP---VLRKGQCC 805
G +C+D+ + +C+ + SC RP + K +CC
Sbjct: 592 GSFRCQCLGGLAVGTDGRVCVDTHVRSTCYG-AIEKGSCARPFPGTVTKSECC 643
Score = 30.8 bits (68), Expect = 6.9
Identities = 51/232 (21%), Positives = 82/232 (35%), Gaps = 49/232 (21%)
Query: 413 GDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACG-- 470
G R+ C + G CV +C + C C C + T+ P+CG
Sbjct: 61 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLC-TCADGTL----APSCGVS 115
Query: 471 ELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELCSER--KQGC----------TLNCPF 518
S C+++ C+NG C CQ T +C + +GC C +
Sbjct: 116 RGSGCSVS---CMNGGTCRGASC-LCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVY 171
Query: 519 GFLTDAQNCE------ICECRPRPKKCR----PIICDKYCPLGLLKNKHG--CDICRCKK 566
GF+ CE C + P+ C+ ++C K + G C++C +
Sbjct: 172 GFM--GPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQP 229
Query: 567 CPELSCSKICPLGFQQDSHGCLICKCREASASAGPPIL--SGTCLTVDGHHH 616
P C GF + H C++ P L G+C+ + G H
Sbjct: 230 HP-------CRRGFIPNIH---TGACQDVDECQAVPGLCQGGSCVNMVGSFH 271
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 68.9 bits (167), Expect = 2e-11
Identities = 154/723 (21%), Positives = 228/723 (31%), Gaps = 207/723 (28%)
Query: 283 GCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVE 342
G C LP C C G G C+ + + G C + ++C+ +T
Sbjct: 243 GSCKLPGDCRCQYGWQGL-YCD-----KCIPHPGCVHGICNEPWQCLCETN--------- 287
Query: 343 YYDGDMFRMDNCRFCRCQGGVAICFTA-QCGEINCERYYV--PEGECCPVCEDPVY---- 395
+ G + D +C G C C ++Y PEG P CE +
Sbjct: 288 -WGGQLCDKD-LNYC---GTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLS 342
Query: 396 -PFNNPAGCYAN--GLILAHGDRWRE-------DDCTFCQCVNGERHCVATVCGQTCTNP 445
P +N C G W DDC+ C +G C V G C P
Sbjct: 343 DPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGT-CQDLVNGFKCVCP 401
Query: 446 VKVPGECCPV----CEEPTIITVDPPACGEL--------------SNCTLTGKDC----- 482
+ G+ C + CE V+ +C L NC + DC
Sbjct: 402 PQWTGKTCQLDANECEAKPC--VNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQ 459
Query: 483 --------INGFK-------------RDHNGCRTCQCINTEELCSERKQGCTLNCPFGFL 521
+NG++ RD + C + C+N +E + L CP GF
Sbjct: 460 NDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCL-CPTGFS 518
Query: 522 TDAQNCEICECRPRP----KKCRPIICDKYCPLGLLKNKHGC----DICRCKKCPEL-SC 572
+ +I C P P +C D +C C D CR C + SC
Sbjct: 519 GNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSC 578
Query: 573 -----------------SKIC-PLG-FQQDSHGCLICKCREA-----------SASAGPP 602
S +C P G + S G C C + + P
Sbjct: 579 TVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPC 638
Query: 603 ILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSC 662
GTC +DG + +C C +G E A + C H G C
Sbjct: 639 RNGGTC--IDGVNSY----------KCICSDGWEG-AYCETNINDCSQNPCHNGGTCRDL 685
Query: 663 ADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQN 722
+DF CH+ + C + TC++G C E C
Sbjct: 686 VNDFYCDCKNGWKGKTCHSRDSQ------------CDEATCNNGGT-CYDEG-DAFKCMC 731
Query: 723 PSRTQDSCCPQCTDQPFRPSLSRNNS-VPNYCKND-----EGDIF--LAAESWKPDVCT- 773
P + + C +++RN+S +PN C N G+ F + E W+ +C
Sbjct: 732 PGGWEGTTC----------NIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQ 781
Query: 774 ------------SCICIDSVISCFSESCPSVSCERPVLRKGQC----CPY---CIEDTIP 814
S C+D E P + + +C C + C+++
Sbjct: 782 NTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEING 841
Query: 815 KKVVCH-----------------FSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPL 857
+ VC G D +WD D C C CL G+ CS V C P
Sbjct: 842 YRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWD-DDCNTCQCLNGRIACSKVWCGPR 900
Query: 858 PCV 860
PC+
Sbjct: 901 PCL 903
Score = 55.8 bits (133), Expect = 2e-07
Identities = 147/671 (21%), Positives = 211/671 (31%), Gaps = 132/671 (19%)
Query: 40 CDESKCEEPRNCPGSIVQGVCGCCY-----TCASQRNESCGGTFGIYGTCD---RGLRCV 91
C C +C + + C C TC++ ++ GTC G +CV
Sbjct: 340 CLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCV 399
Query: 92 IRPPLNGDSLTEYEAGVCEDENWTDDQLLGFKPCNENLIAG--CNIING----KCECNT- 144
P G + + +A CE + + K C +NLIA C+ + G C+ N
Sbjct: 400 CPPQWTGKTC-QLDANECEAK-----PCVNAKSC-KNLIASYYCDCLPGWMGQNCDININ 452
Query: 145 --IRTCSNPF---EFPSQDMCLS----ALKRIEEEKPDCSKARCEVQFSPRCPEDSVLIE 195
+ C N + + C+ A E + +C+ C C + +
Sbjct: 453 DCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPC--LNGGHCQNEINRFQ 510
Query: 196 GYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVD- 254
P G L C + C CQ G ++AS +C + YE K +
Sbjct: 511 CLCPTGFSGNL---CQLDIDYCEPNPCQNGAQ--CYNRASDYFCKCPEDYEGKNCSHLKD 565
Query: 255 -CRTVECPPVQQTACPPDSYETQ--VRLTADGCCTLPTRCECLSGLCGFPVCEVGSTPRI 311
CRT C + S +T VR + C +C+ SG G C+
Sbjct: 566 HCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSG--GKFTCDCNK---- 619
Query: 312 VSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGV--AICFTA 369
G G C E +ND + N DG N C C G A C T
Sbjct: 620 -----GFTGTYCH--ENINDCESNPCRNGGTCIDGV-----NSYKCICSDGWEGAYCETN 667
Query: 370 --QCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCV 427
C + C C D V F C R+ C C
Sbjct: 668 INDCSQNPCHNG--------GTCRDLVNDFY----CDCKNGWKGKTCHSRDSQCDEATCN 715
Query: 428 NGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKD----CI 483
NG C C P G C + + + P C C + G+ C
Sbjct: 716 NGGT-CYDEGDAFKCMCPGGWEGTTCNIARNSSCL---PNPCHNGGTCVVNGESFTCVCK 771
Query: 484 NGFK-----RDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKK 538
G++ ++ N C C N+ C + C GF I EC+ P
Sbjct: 772 EGWEGPICAQNTNDCSPHPCYNSGT-CVDGDNWYRCECAPGFAGPDCRININECQSSPCA 830
Query: 539 CRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASAS 598
D+ N + C +CP G KC+E S
Sbjct: 831 FGATCVDEI-------NGYRC---------------VCPPGHSG-------AKCQEVS-- 859
Query: 599 AGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPAC----GNPTIH 654
G P ++ + DG W D C C CLNGR C+ + C C G+
Sbjct: 860 -GRPCITMGSVIPDG------AKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECP 912
Query: 655 PGQCCPSCADD 665
GQ C DD
Sbjct: 913 SGQSCIPILDD 923
>gi|169212026 PREDICTED: keratin associated protein [Homo sapiens]
Length = 517
Score = 68.9 bits (167), Expect = 2e-11
Identities = 97/419 (23%), Positives = 141/419 (33%), Gaps = 89/419 (21%)
Query: 494 RTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLL 553
+T Q + ++ C G P +C + C +P C P+IC+ C +
Sbjct: 38 QTWQLVTCQDSCGSSSCGPQCRQP--------SCPVSSCA-QPLCCDPVICEPSCSVS-- 86
Query: 554 KNKHGCD-ICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVD 612
GC +C C +C C + C C EA+ +S C V
Sbjct: 87 ---SGCQPVC----CEATTCEPSCSVS------NCYQPVCFEATICEPSCSVSNCCQPV- 132
Query: 613 GHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPE 672
C E C++ +C P C P I C PSC
Sbjct: 133 -------------CFEATICE--PSCSVSSCAQPVCCEPAI----CEPSC---------- 163
Query: 673 LSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQN---------P 723
S S C G E + C +C VLC++ C P++C+ P
Sbjct: 164 -SVSSCCQPVGSE----ATSCQPVLCVPTSCQP--VLCKSSCCQPVVCEPSCCSAVCTLP 216
Query: 724 SRTQDSCCPQCTDQPF--RPSLSRNNSVPNYCKNDEGDIFLAAES--WKPDVCTSCICID 779
S Q C QP P+ S +S C + +ES +P C + +C
Sbjct: 217 SSCQPVVCEPSCCQPVCPTPTCSVTSSCQAVCCDPSPCEPTCSESSICQPATCVALVCEP 276
Query: 780 SV---ISCFSESC--PSV--SCERPVLRKGQCC-PYCIEDTIPKKVVCHFSGKAYADEER 831
+ C SC PSV +C+ P C P C E + VC S
Sbjct: 277 VCLRPVCCVQSSCEPPSVPSTCQEPSCCVSSICQPICSEPSPCSPAVCVSSP---CQPTC 333
Query: 832 WDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMCPE-MYVPEPTNIPIEKT 889
+ + C C + + C + SC PL C + C P CP Y+P + P T
Sbjct: 334 YVVKRC-RSVCPEPVS-CPSTSCRPLSCSPGSSASAICRPTCPRTFYIPSSSKRPCSAT 390
Score = 65.9 bits (159), Expect = 2e-10
Identities = 104/425 (24%), Positives = 142/425 (33%), Gaps = 86/425 (20%)
Query: 142 CNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCEVQFSPRCPEDSVLIEGYAPPG 201
C+T +C P PS C S ++ + C + C P+C + S + A P
Sbjct: 19 CSTEVSCGGPICLPSS--CQSQTWQLVTCQDSCGSSSC----GPQCRQPSCPVSSCAQPL 72
Query: 202 ECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGV-DCRTVEC 260
C P+ +C P+ + CQP CC+ C+P V +C C
Sbjct: 73 CCDPV----ICEPSCSVSSGCQP---------------VCCEATTCEPSCSVSNCYQPVC 113
Query: 261 PPVQQTACPPDSYETQVRLTADGCCTLPTRCE--CLSGLCGFPVCEVGSTPRIVSRGDGT 318
+ T C P V C T CE C C PVC P I
Sbjct: 114 --FEATICEP---SCSVSNCCQPVCFEATICEPSCSVSSCAQPVC---CEPAICEPSCSV 165
Query: 319 PGKCCDVFECVNDTKPA-CVFNNVEYYDGDMFRMDNCRFCRCQGGVA--ICFTAQCGEIN 375
C V +P CV + + C+ CQ V C +A C +
Sbjct: 166 SSCCQPVGSEATSCQPVLCVPTSCQPV--------LCKSSCCQPVVCEPSCCSAVCTLPS 217
Query: 376 CERYYVPEGECC-PVCEDPVYPFNNPAGCYANGLILAHGDRWREDDC---TFCQCVNGER 431
+ V E CC PVC P + C A + E C + CQ
Sbjct: 218 SCQPVVCEPSCCQPVCPTPTCSVT--SSCQA----VCCDPSPCEPTCSESSICQPAT--- 268
Query: 432 HCVATVCGQTCTNPVKVPGECC--PVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRD 489
CVA VC C PV CC CE P++ P C E S C +
Sbjct: 269 -CVALVCEPVCLRPV-----CCVQSSCEPPSV----PSTCQEPSCCV---SSICQPICSE 315
Query: 490 HNGCRTCQCINT--EELCSERKQGCTLNCPFGFLTDAQNCEICECRP---RPKKCRPIIC 544
+ C C+++ + C K+ C CP + +C CRP P IC
Sbjct: 316 PSPCSPAVCVSSPCQPTCYVVKR-CRSVCP-----EPVSCPSTSCRPLSCSPGSSASAIC 369
Query: 545 DKYCP 549
CP
Sbjct: 370 RPTCP 374
Score = 49.3 bits (116), Expect = 2e-05
Identities = 120/566 (21%), Positives = 169/566 (29%), Gaps = 196/566 (34%)
Query: 194 IEGYAPPGECCPLPSRCVCNP-AGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFG 252
+ G +C +P+ +C+ C +C P + + L C+
Sbjct: 1 MSGSCSSRKCFSVPATSLCSTEVSCGGPICLPSSCQ----------SQTWQLVTCQD--- 47
Query: 253 VDCRTVEC-PPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSGLCGFPVCEVGSTPRI 311
C + C P +Q +CP S A C P CE P C V S
Sbjct: 48 -SCGSSSCGPQCRQPSCPVSS-------CAQPLCCDPVICE--------PSCSVSS---- 87
Query: 312 VSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCR-FCR----CQGGVAIC 366
G CC+ C +P+C +N Y F C C CQ +C
Sbjct: 88 -----GCQPVCCEATTC----EPSCSVSNC--YQPVCFEATICEPSCSVSNCCQ---PVC 133
Query: 367 FTAQCGEINCERYYVPEGECCP--VCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFC 424
F A E +C + CC +CE C + G + T C
Sbjct: 134 FEATICEPSCSVSSCAQPVCCEPAICEP---------SCSVSSCCQPVGS-----EATSC 179
Query: 425 Q---CVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKD 481
Q CV C +C +C PV VCE P C + CTL
Sbjct: 180 QPVLCV--PTSCQPVLCKSSCCQPV--------VCE--------PSCCSAV--CTLPS-- 217
Query: 482 CINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRP 541
+CQ + E C C CP + +C+ C P P C P
Sbjct: 218 -------------SCQPVVCEPSC------CQPVCPTPTCSVTSSCQAVCCDPSP--CEP 256
Query: 542 IICDKYCPLGLLKNKHGCDICRCKKCPELSCSKIC--PLGFQQDSHGCLICKCREASASA 599
+ IC+ C L C +C P+ C + +S
Sbjct: 257 TCSES-------------SICQPATCVALVCEPVCLRPV--------CCV------QSSC 289
Query: 600 GPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCC 659
PP + TC E S C++ +C I C C
Sbjct: 290 EPPSVPSTC---------QEPS--------CCVS--SICQPICSEPSPCSPAVCVSSPCQ 330
Query: 660 PSCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLL 719
P+C +VV++ S+C P V C + C PL
Sbjct: 331 PTC---YVVKR----CRSVCPEP-------------------------VSCPSTSCRPLS 358
Query: 720 CQNPSRTQDSCCPQCTDQPFRPSLSR 745
C S C P C + PS S+
Sbjct: 359 CSPGSSASAICRPTCPRTFYIPSSSK 384
Score = 46.2 bits (108), Expect = 2e-04
Identities = 62/201 (30%), Positives = 77/201 (38%), Gaps = 32/201 (15%)
Query: 697 SCTQCTCHS--GRVLCETEV------CPPLLCQNPS----RTQDSC----C-PQCTDQPF 739
SC+ C S LC TEV C P CQ+ + QDSC C PQC QP
Sbjct: 4 SCSSRKCFSVPATSLCSTEVSCGGPICLPSSCQSQTWQLVTCQDSCGSSSCGPQCR-QPS 62
Query: 740 RPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVC---TSCICIDSVISCFSESCPSVSCER 796
P S + P C + + S VC T+C SV +C+ C +
Sbjct: 63 CPVSS--CAQPLCCDPVICEPSCSVSSGCQPVCCEATTCEPSCSVSNCYQPVCFEATICE 120
Query: 797 PVLRKGQCC-PYCIEDTIPKKVVCHFSGKA--YADEERWDLDSCTHCYCLQ----GQTLC 849
P CC P C E TI + C S A E SC+ C Q T C
Sbjct: 121 PSCSVSNCCQPVCFEATICEP-SCSVSSCAQPVCCEPAICEPSCSVSSCCQPVGSEATSC 179
Query: 850 STVSCPPLPCVEPINVEGSCC 870
V C P C +P+ + SCC
Sbjct: 180 QPVLCVPTSC-QPVLCKSSCC 199
Score = 42.7 bits (99), Expect = 0.002
Identities = 81/391 (20%), Positives = 118/391 (30%), Gaps = 87/391 (22%)
Query: 44 KCEEPRNCP-GSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRCVIRPPLNGDSLT 102
+C +P +CP S Q +C C SC + G C C P + +
Sbjct: 57 QCRQP-SCPVSSCAQPLCCDPVIC----EPSCSVSSGCQPVCCEATTC--EPSCSVSNCY 109
Query: 103 E---YEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIR--TCSNPFEFPSQ 157
+ +EA +CE C + + I C ++ C P
Sbjct: 110 QPVCFEATICEPS-------CSVSNCCQPVCFEATICEPSCSVSSCAQPVCCEPAICEPS 162
Query: 158 DMCLSALKRIEEEKPDCSKARC-EVQFSPRCPEDSVLIEGYAPPGEC---CPLPSRCVCN 213
S + + E C C P + S P C C LPS C
Sbjct: 163 CSVSSCCQPVGSEATSCQPVLCVPTSCQPVLCKSSCCQPVVCEPSCCSAVCTLPSSC--Q 220
Query: 214 PAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFG-------VDCRTVECPPV--- 263
P C CQP S S CCD C+P C + C PV
Sbjct: 221 PVVCEPSCCQPVCPTPTCSVTSSCQAVCCDPSPCEPTCSESSICQPATCVALVCEPVCLR 280
Query: 264 ----QQTACPPDSYETQVRLTADGCCTLPTRCE----CLSGLCGFPVCEVGSTPRIVSRG 315
Q++C P S +P+ C+ C+S +C P+C
Sbjct: 281 PVCCVQSSCEPPS--------------VPSTCQEPSCCVSSICQ-PIC------------ 313
Query: 316 DGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEIN 375
P C + +P C + + CR C V+ C + C ++
Sbjct: 314 -SEPSPCSPAVCVSSPCQPTC------------YVVKRCRSV-CPEPVS-CPSTSCRPLS 358
Query: 376 CERYYVPEGECCPVCEDPVY-PFNNPAGCYA 405
C C P C Y P ++ C A
Sbjct: 359 CSPGSSASAICRPTCPRTFYIPSSSKRPCSA 389
>gi|169211819 PREDICTED: keratin associated protein [Homo sapiens]
Length = 517
Score = 68.2 bits (165), Expect = 4e-11
Identities = 97/419 (23%), Positives = 141/419 (33%), Gaps = 89/419 (21%)
Query: 494 RTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLL 553
+T Q + ++ C G P +C + C +P C P+IC+ C +
Sbjct: 38 QTWQLVTCQDSCGSSSCGPQCRQP--------SCPVSSCA-QPLCCDPVICEPSCSVS-- 86
Query: 554 KNKHGCD-ICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVD 612
GC +C C +C C + C C EA+ +S C V
Sbjct: 87 ---SGCQPVC----CEATTCEPSCSVS------NCYQPVCFEATICEPSCSVSNCCQPV- 132
Query: 613 GHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPE 672
C E C++ +C P C P I C PSC
Sbjct: 133 -------------CFEATVCE--PSCSVSSCAQPVCCEPAI----CEPSC---------- 163
Query: 673 LSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQN---------P 723
S S C G E + C +C VLC++ C P++C+ P
Sbjct: 164 -SVSSCCQPVGSE----ATSCQPVLCVPTSCQP--VLCKSSCCQPVVCEPSCCSAVCTLP 216
Query: 724 SRTQDSCCPQCTDQPF--RPSLSRNNSVPNYCKNDEGDIFLAAES--WKPDVCTSCICID 779
S Q C QP P+ S +S C + +ES +P C + +C
Sbjct: 217 SSCQPVVCEPSCCQPVCPTPTCSVTSSCQAVCCDPSPCEPSCSESSICQPATCVALVCEP 276
Query: 780 SV---ISCFSESC--PSV--SCERPVLRKGQCC-PYCIEDTIPKKVVCHFSGKAYADEER 831
+ C SC PSV +C+ P C P C E + VC S
Sbjct: 277 VCLRPVCCVQSSCEPPSVPSTCQEPSCCVSSICQPICSEPSPCSPAVCVSSP---CQPTC 333
Query: 832 WDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMCPE-MYVPEPTNIPIEKT 889
+ + C C + + C + SC PL C + C P CP Y+P + P T
Sbjct: 334 YVVKRCPSV-CPEPVS-CPSTSCRPLSCSPGSSASAICRPTCPRTFYIPSSSKRPCSAT 390
Score = 66.2 bits (160), Expect = 1e-10
Identities = 104/425 (24%), Positives = 142/425 (33%), Gaps = 86/425 (20%)
Query: 142 CNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCEVQFSPRCPEDSVLIEGYAPPG 201
C+T +C P PS C S ++ + C + C P+C + S + A P
Sbjct: 19 CSTEVSCGGPICLPSS--CQSQTWQLVTCQDSCGSSSC----GPQCRQPSCPVSSCAQPL 72
Query: 202 ECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGV-DCRTVEC 260
C P+ +C P+ + CQP CC+ C+P V +C C
Sbjct: 73 CCDPV----ICEPSCSVSSGCQP---------------VCCEATTCEPSCSVSNCYQPVC 113
Query: 261 PPVQQTACPPDSYETQVRLTADGCCTLPTRCE--CLSGLCGFPVCEVGSTPRIVSRGDGT 318
+ T C P V C T CE C C PVC P I
Sbjct: 114 --FEATICEP---SCSVSNCCQPVCFEATVCEPSCSVSSCAQPVC---CEPAICEPSCSV 165
Query: 319 PGKCCDVFECVNDTKPA-CVFNNVEYYDGDMFRMDNCRFCRCQGGVA--ICFTAQCGEIN 375
C V +P CV + + C+ CQ V C +A C +
Sbjct: 166 SSCCQPVGSEATSCQPVLCVPTSCQPV--------LCKSSCCQPVVCEPSCCSAVCTLPS 217
Query: 376 CERYYVPEGECC-PVCEDPVYPFNNPAGCYANGLILAHGDRWREDDC---TFCQCVNGER 431
+ V E CC PVC P + C A + E C + CQ
Sbjct: 218 SCQPVVCEPSCCQPVCPTPTCSVT--SSCQA----VCCDPSPCEPSCSESSICQPAT--- 268
Query: 432 HCVATVCGQTCTNPVKVPGECC--PVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRD 489
CVA VC C PV CC CE P++ P C E S C +
Sbjct: 269 -CVALVCEPVCLRPV-----CCVQSSCEPPSV----PSTCQEPSCCV---SSICQPICSE 315
Query: 490 HNGCRTCQCINT--EELCSERKQGCTLNCPFGFLTDAQNCEICECRP---RPKKCRPIIC 544
+ C C+++ + C K+ C CP + +C CRP P IC
Sbjct: 316 PSPCSPAVCVSSPCQPTCYVVKR-CPSVCP-----EPVSCPSTSCRPLSCSPGSSASAIC 369
Query: 545 DKYCP 549
CP
Sbjct: 370 RPTCP 374
Score = 52.4 bits (124), Expect = 2e-06
Identities = 121/566 (21%), Positives = 170/566 (30%), Gaps = 196/566 (34%)
Query: 194 IEGYAPPGECCPLPSRCVCNP-AGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFG 252
+ G +C +P+ +C+ C +C P + + L C+
Sbjct: 1 MSGSCSSRKCFSVPATSLCSTEVSCGGPICLPSSCQ----------SQTWQLVTCQD--- 47
Query: 253 VDCRTVEC-PPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSGLCGFPVCEVGSTPRI 311
C + C P +Q +CP S A C P CE P C V S
Sbjct: 48 -SCGSSSCGPQCRQPSCPVSS-------CAQPLCCDPVICE--------PSCSVSS---- 87
Query: 312 VSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCR-FCR----CQGGVAIC 366
G CC+ C +P+C +N Y F C C CQ +C
Sbjct: 88 -----GCQPVCCEATTC----EPSCSVSNC--YQPVCFEATICEPSCSVSNCCQ---PVC 133
Query: 367 FTAQCGEINCERYYVPEGECCP--VCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFC 424
F A E +C + CC +CE C + G + T C
Sbjct: 134 FEATVCEPSCSVSSCAQPVCCEPAICEP---------SCSVSSCCQPVGS-----EATSC 179
Query: 425 Q---CVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKD 481
Q CV C +C +C PV VCE P C + CTL
Sbjct: 180 QPVLCV--PTSCQPVLCKSSCCQPV--------VCE--------PSCCSAV--CTLPS-- 217
Query: 482 CINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRP 541
+CQ + E C C CP + +C+ C P P C P
Sbjct: 218 -------------SCQPVVCEPSC------CQPVCPTPTCSVTSSCQAVCCDPSP--CEP 256
Query: 542 IICDKYCPLGLLKNKHGCDICRCKKCPELSCSKIC--PLGFQQDSHGCLICKCREASASA 599
+ IC+ C L C +C P+ C + +S
Sbjct: 257 SCSES-------------SICQPATCVALVCEPVCLRPV--------CCV------QSSC 289
Query: 600 GPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCC 659
PP + TC E S C++ +C I C C
Sbjct: 290 EPPSVPSTC---------QEPS--------CCVS--SICQPICSEPSPCSPAVCVSSPCQ 330
Query: 660 PSCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLL 719
P+C +VV++ PS+C P V C + C PL
Sbjct: 331 PTC---YVVKR----CPSVCPEP-------------------------VSCPSTSCRPLS 358
Query: 720 CQNPSRTQDSCCPQCTDQPFRPSLSR 745
C S C P C + PS S+
Sbjct: 359 CSPGSSASAICRPTCPRTFYIPSSSK 384
Score = 45.8 bits (107), Expect = 2e-04
Identities = 61/201 (30%), Positives = 77/201 (38%), Gaps = 32/201 (15%)
Query: 697 SCTQCTCHS--GRVLCETEV------CPPLLCQNPS----RTQDSC----C-PQCTDQPF 739
SC+ C S LC TEV C P CQ+ + QDSC C PQC QP
Sbjct: 4 SCSSRKCFSVPATSLCSTEVSCGGPICLPSSCQSQTWQLVTCQDSCGSSSCGPQCR-QPS 62
Query: 740 RPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVC---TSCICIDSVISCFSESCPSVSCER 796
P S + P C + + S VC T+C SV +C+ C +
Sbjct: 63 CPVSS--CAQPLCCDPVICEPSCSVSSGCQPVCCEATTCEPSCSVSNCYQPVCFEATICE 120
Query: 797 PVLRKGQCC-PYCIEDTIPKKVVCHFSGKA--YADEERWDLDSCTHCYCLQ----GQTLC 849
P CC P C E T+ + C S A E SC+ C Q T C
Sbjct: 121 PSCSVSNCCQPVCFEATVCEP-SCSVSSCAQPVCCEPAICEPSCSVSSCCQPVGSEATSC 179
Query: 850 STVSCPPLPCVEPINVEGSCC 870
V C P C +P+ + SCC
Sbjct: 180 QPVLCVPTSC-QPVLCKSSCC 199
Score = 40.8 bits (94), Expect = 0.007
Identities = 67/319 (21%), Positives = 94/319 (29%), Gaps = 50/319 (15%)
Query: 44 KCEEPRNCP-GSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRCVIRPPLNGDSLT 102
+C +P +CP S Q +C C SC + G C C P + +
Sbjct: 57 QCRQP-SCPVSSCAQPLCCDPVIC----EPSCSVSSGCQPVCCEATTC--EPSCSVSNCY 109
Query: 103 E---YEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIR--TCSNPFEFPSQ 157
+ +EA +CE C + + + C ++ C P
Sbjct: 110 QPVCFEATICEPS-------CSVSNCCQPVCFEATVCEPSCSVSSCAQPVCCEPAICEPS 162
Query: 158 DMCLSALKRIEEEKPDCSKARC-EVQFSPRCPEDSVLIEGYAPPGEC---CPLPSRCVCN 213
S + + E C C P + S P C C LPS C
Sbjct: 163 CSVSSCCQPVGSEATSCQPVLCVPTSCQPVLCKSSCCQPVVCEPSCCSAVCTLPSSC--Q 220
Query: 214 PAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFG-------VDCRTVECPPV--- 263
P C CQP S S CCD C+P C + C PV
Sbjct: 221 PVVCEPSCCQPVCPTPTCSVTSSCQAVCCDPSPCEPSCSESSICQPATCVALVCEPVCLR 280
Query: 264 ----QQTACPPDSYETQ-------VRLTADGCCTLPTRCE---CLSGLCGFPVCEVGSTP 309
Q++C P S + V C+ P+ C C+S C V P
Sbjct: 281 PVCCVQSSCEPPSVPSTCQEPSCCVSSICQPICSEPSPCSPAVCVSSPCQPTCYVVKRCP 340
Query: 310 RIVSRGDGTPGKCCDVFEC 328
+ P C C
Sbjct: 341 SVCPEPVSCPSTSCRPLSC 359
>gi|239745811 PREDICTED: hypothetical protein XP_002343557 [Homo
sapiens]
Length = 517
Score = 68.2 bits (165), Expect = 4e-11
Identities = 97/419 (23%), Positives = 141/419 (33%), Gaps = 89/419 (21%)
Query: 494 RTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLL 553
+T Q + ++ C G P +C + C +P C P+IC+ C +
Sbjct: 38 QTWQLVTCQDSCGSSSCGPQCRQP--------SCPVSSCA-QPLCCDPVICEPSCSVS-- 86
Query: 554 KNKHGCD-ICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVD 612
GC +C C +C C + C C EA+ +S C V
Sbjct: 87 ---SGCQPVC----CEATTCEPSCSVS------NCYQPVCFEATICEPSCSVSNCCQPV- 132
Query: 613 GHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPE 672
C E C++ +C P C P I C PSC
Sbjct: 133 -------------CFEATVCE--PSCSVSSCAQPVCCEPAI----CEPSC---------- 163
Query: 673 LSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQN---------P 723
S S C G E + C +C VLC++ C P++C+ P
Sbjct: 164 -SVSSCCQPVGSE----ATSCQPVLCVPTSCQP--VLCKSSCCQPVVCEPSCCSAVCTLP 216
Query: 724 SRTQDSCCPQCTDQPF--RPSLSRNNSVPNYCKNDEGDIFLAAES--WKPDVCTSCICID 779
S Q C QP P+ S +S C + +ES +P C + +C
Sbjct: 217 SSCQPVVCEPSCCQPVCPTPTCSVTSSCQAVCCDPSPCEPSCSESSICQPATCVALVCEP 276
Query: 780 SV---ISCFSESC--PSV--SCERPVLRKGQCC-PYCIEDTIPKKVVCHFSGKAYADEER 831
+ C SC PSV +C+ P C P C E + VC S
Sbjct: 277 VCLRPVCCVQSSCEPPSVPSTCQEPSCCVSSICQPICSEPSPCSPAVCVSSP---CQPTC 333
Query: 832 WDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMCPE-MYVPEPTNIPIEKT 889
+ + C C + + C + SC PL C + C P CP Y+P + P T
Sbjct: 334 YVVKRCPSV-CPEPVS-CPSTSCRPLSCSPGSSASAICRPTCPRTFYIPSSSKRPCSAT 390
Score = 66.2 bits (160), Expect = 1e-10
Identities = 104/425 (24%), Positives = 142/425 (33%), Gaps = 86/425 (20%)
Query: 142 CNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCEVQFSPRCPEDSVLIEGYAPPG 201
C+T +C P PS C S ++ + C + C P+C + S + A P
Sbjct: 19 CSTEVSCGGPICLPSS--CQSQTWQLVTCQDSCGSSSC----GPQCRQPSCPVSSCAQPL 72
Query: 202 ECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGV-DCRTVEC 260
C P+ +C P+ + CQP CC+ C+P V +C C
Sbjct: 73 CCDPV----ICEPSCSVSSGCQP---------------VCCEATTCEPSCSVSNCYQPVC 113
Query: 261 PPVQQTACPPDSYETQVRLTADGCCTLPTRCE--CLSGLCGFPVCEVGSTPRIVSRGDGT 318
+ T C P V C T CE C C PVC P I
Sbjct: 114 --FEATICEP---SCSVSNCCQPVCFEATVCEPSCSVSSCAQPVC---CEPAICEPSCSV 165
Query: 319 PGKCCDVFECVNDTKPA-CVFNNVEYYDGDMFRMDNCRFCRCQGGVA--ICFTAQCGEIN 375
C V +P CV + + C+ CQ V C +A C +
Sbjct: 166 SSCCQPVGSEATSCQPVLCVPTSCQPV--------LCKSSCCQPVVCEPSCCSAVCTLPS 217
Query: 376 CERYYVPEGECC-PVCEDPVYPFNNPAGCYANGLILAHGDRWREDDC---TFCQCVNGER 431
+ V E CC PVC P + C A + E C + CQ
Sbjct: 218 SCQPVVCEPSCCQPVCPTPTCSVT--SSCQA----VCCDPSPCEPSCSESSICQPAT--- 268
Query: 432 HCVATVCGQTCTNPVKVPGECC--PVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRD 489
CVA VC C PV CC CE P++ P C E S C +
Sbjct: 269 -CVALVCEPVCLRPV-----CCVQSSCEPPSV----PSTCQEPSCCV---SSICQPICSE 315
Query: 490 HNGCRTCQCINT--EELCSERKQGCTLNCPFGFLTDAQNCEICECRP---RPKKCRPIIC 544
+ C C+++ + C K+ C CP + +C CRP P IC
Sbjct: 316 PSPCSPAVCVSSPCQPTCYVVKR-CPSVCP-----EPVSCPSTSCRPLSCSPGSSASAIC 369
Query: 545 DKYCP 549
CP
Sbjct: 370 RPTCP 374
Score = 52.4 bits (124), Expect = 2e-06
Identities = 121/566 (21%), Positives = 170/566 (30%), Gaps = 196/566 (34%)
Query: 194 IEGYAPPGECCPLPSRCVCNP-AGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFG 252
+ G +C +P+ +C+ C +C P + + L C+
Sbjct: 1 MSGSCSSRKCFSVPATSLCSTEVSCGGPICLPSSCQ----------SQTWQLVTCQD--- 47
Query: 253 VDCRTVEC-PPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSGLCGFPVCEVGSTPRI 311
C + C P +Q +CP S A C P CE P C V S
Sbjct: 48 -SCGSSSCGPQCRQPSCPVSS-------CAQPLCCDPVICE--------PSCSVSS---- 87
Query: 312 VSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCR-FCR----CQGGVAIC 366
G CC+ C +P+C +N Y F C C CQ +C
Sbjct: 88 -----GCQPVCCEATTC----EPSCSVSNC--YQPVCFEATICEPSCSVSNCCQ---PVC 133
Query: 367 FTAQCGEINCERYYVPEGECCP--VCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFC 424
F A E +C + CC +CE C + G + T C
Sbjct: 134 FEATVCEPSCSVSSCAQPVCCEPAICEP---------SCSVSSCCQPVGS-----EATSC 179
Query: 425 Q---CVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKD 481
Q CV C +C +C PV VCE P C + CTL
Sbjct: 180 QPVLCV--PTSCQPVLCKSSCCQPV--------VCE--------PSCCSAV--CTLPS-- 217
Query: 482 CINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRP 541
+CQ + E C C CP + +C+ C P P C P
Sbjct: 218 -------------SCQPVVCEPSC------CQPVCPTPTCSVTSSCQAVCCDPSP--CEP 256
Query: 542 IICDKYCPLGLLKNKHGCDICRCKKCPELSCSKIC--PLGFQQDSHGCLICKCREASASA 599
+ IC+ C L C +C P+ C + +S
Sbjct: 257 SCSES-------------SICQPATCVALVCEPVCLRPV--------CCV------QSSC 289
Query: 600 GPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCC 659
PP + TC E S C++ +C I C C
Sbjct: 290 EPPSVPSTC---------QEPS--------CCVS--SICQPICSEPSPCSPAVCVSSPCQ 330
Query: 660 PSCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLL 719
P+C +VV++ PS+C P V C + C PL
Sbjct: 331 PTC---YVVKR----CPSVCPEP-------------------------VSCPSTSCRPLS 358
Query: 720 CQNPSRTQDSCCPQCTDQPFRPSLSR 745
C S C P C + PS S+
Sbjct: 359 CSPGSSASAICRPTCPRTFYIPSSSK 384
Score = 45.8 bits (107), Expect = 2e-04
Identities = 61/201 (30%), Positives = 77/201 (38%), Gaps = 32/201 (15%)
Query: 697 SCTQCTCHS--GRVLCETEV------CPPLLCQNPS----RTQDSC----C-PQCTDQPF 739
SC+ C S LC TEV C P CQ+ + QDSC C PQC QP
Sbjct: 4 SCSSRKCFSVPATSLCSTEVSCGGPICLPSSCQSQTWQLVTCQDSCGSSSCGPQCR-QPS 62
Query: 740 RPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVC---TSCICIDSVISCFSESCPSVSCER 796
P S + P C + + S VC T+C SV +C+ C +
Sbjct: 63 CPVSS--CAQPLCCDPVICEPSCSVSSGCQPVCCEATTCEPSCSVSNCYQPVCFEATICE 120
Query: 797 PVLRKGQCC-PYCIEDTIPKKVVCHFSGKA--YADEERWDLDSCTHCYCLQ----GQTLC 849
P CC P C E T+ + C S A E SC+ C Q T C
Sbjct: 121 PSCSVSNCCQPVCFEATVCEP-SCSVSSCAQPVCCEPAICEPSCSVSSCCQPVGSEATSC 179
Query: 850 STVSCPPLPCVEPINVEGSCC 870
V C P C +P+ + SCC
Sbjct: 180 QPVLCVPTSC-QPVLCKSSCC 199
Score = 40.8 bits (94), Expect = 0.007
Identities = 67/319 (21%), Positives = 94/319 (29%), Gaps = 50/319 (15%)
Query: 44 KCEEPRNCP-GSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRCVIRPPLNGDSLT 102
+C +P +CP S Q +C C SC + G C C P + +
Sbjct: 57 QCRQP-SCPVSSCAQPLCCDPVIC----EPSCSVSSGCQPVCCEATTC--EPSCSVSNCY 109
Query: 103 E---YEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIR--TCSNPFEFPSQ 157
+ +EA +CE C + + + C ++ C P
Sbjct: 110 QPVCFEATICEPS-------CSVSNCCQPVCFEATVCEPSCSVSSCAQPVCCEPAICEPS 162
Query: 158 DMCLSALKRIEEEKPDCSKARC-EVQFSPRCPEDSVLIEGYAPPGEC---CPLPSRCVCN 213
S + + E C C P + S P C C LPS C
Sbjct: 163 CSVSSCCQPVGSEATSCQPVLCVPTSCQPVLCKSSCCQPVVCEPSCCSAVCTLPSSC--Q 220
Query: 214 PAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFG-------VDCRTVECPPV--- 263
P C CQP S S CCD C+P C + C PV
Sbjct: 221 PVVCEPSCCQPVCPTPTCSVTSSCQAVCCDPSPCEPSCSESSICQPATCVALVCEPVCLR 280
Query: 264 ----QQTACPPDSYETQ-------VRLTADGCCTLPTRCE---CLSGLCGFPVCEVGSTP 309
Q++C P S + V C+ P+ C C+S C V P
Sbjct: 281 PVCCVQSSCEPPSVPSTCQEPSCCVSSICQPICSEPSPCSPAVCVSSPCQPTCYVVKRCP 340
Query: 310 RIVSRGDGTPGKCCDVFEC 328
+ P C C
Sbjct: 341 SVCPEPVSCPSTSCRPLSC 359
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.490
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,611,678
Number of Sequences: 37866
Number of extensions: 3021069
Number of successful extensions: 11113
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 297
Number of HSP's that attempted gapping in prelim test: 6235
Number of HSP's gapped (non-prelim): 2355
length of query: 1036
length of database: 18,247,518
effective HSP length: 112
effective length of query: 924
effective length of database: 14,006,526
effective search space: 12942030024
effective search space used: 12942030024
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.