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Search of human proteins with 18640738
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain
containing 1 [Homo sapiens]
(475 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain ... 938 0.0
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 98 2e-20
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 98 2e-20
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 98 2e-20
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 98 2e-20
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 94 2e-19
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 94 2e-19
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 94 2e-19
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 88 1e-17
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 88 1e-17
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 88 1e-17
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 88 1e-17
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 88 1e-17
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 87 4e-17
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 86 7e-17
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 86 1e-16
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 84 2e-16
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 84 3e-16
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 83 5e-16
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 83 6e-16
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 83 6e-16
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 83 6e-16
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 82 1e-15
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 82 1e-15
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 79 7e-15
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 79 9e-15
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 78 2e-14
gi|16975496 cortactin binding protein 2 [Homo sapiens] 78 2e-14
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 78 2e-14
gi|34304381 inversin isoform a [Homo sapiens] 75 1e-13
>gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain
containing 1 [Homo sapiens]
Length = 475
Score = 938 bits (2424), Expect = 0.0
Identities = 475/475 (100%), Positives = 475/475 (100%)
Query: 1 MAASALRGLPVAGGGESSESEDDGWEIGYLDRTSQKLKRLLPIEEKKEKFKKAMTIGDVS 60
MAASALRGLPVAGGGESSESEDDGWEIGYLDRTSQKLKRLLPIEEKKEKFKKAMTIGDVS
Sbjct: 1 MAASALRGLPVAGGGESSESEDDGWEIGYLDRTSQKLKRLLPIEEKKEKFKKAMTIGDVS 60
Query: 61 LVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACS 120
LVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACS
Sbjct: 61 LVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACS 120
Query: 121 AHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDE 180
AHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDE
Sbjct: 121 AHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDE 180
Query: 181 NGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNP 240
NGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNP
Sbjct: 181 NGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNP 240
Query: 241 LEGKLQQLTKEDTICKILTTDSDREKDHIFSSYTAFGDLEVFLHGLGLEHMTDLLKERDI 300
LEGKLQQLTKEDTICKILTTDSDREKDHIFSSYTAFGDLEVFLHGLGLEHMTDLLKERDI
Sbjct: 241 LEGKLQQLTKEDTICKILTTDSDREKDHIFSSYTAFGDLEVFLHGLGLEHMTDLLKERDI 300
Query: 301 TLRHLLTMREDEFTKNGITSKDQQKILAALKELQVEEIQFGELSEETKLEISGDEFLNFL 360
TLRHLLTMREDEFTKNGITSKDQQKILAALKELQVEEIQFGELSEETKLEISGDEFLNFL
Sbjct: 301 TLRHLLTMREDEFTKNGITSKDQQKILAALKELQVEEIQFGELSEETKLEISGDEFLNFL 360
Query: 361 LKLNKQCGHLITAVQNVITELPVNSQKITLEWASPQNFTSVCEELVNNVEDLSEKVCKLK 420
LKLNKQCGHLITAVQNVITELPVNSQKITLEWASPQNFTSVCEELVNNVEDLSEKVCKLK
Sbjct: 361 LKLNKQCGHLITAVQNVITELPVNSQKITLEWASPQNFTSVCEELVNNVEDLSEKVCKLK 420
Query: 421 DLIQKLQNERENDPTHIQLREEVSTWNSRILKRTAITICGFGFLLFICKLTFQRK 475
DLIQKLQNERENDPTHIQLREEVSTWNSRILKRTAITICGFGFLLFICKLTFQRK
Sbjct: 421 DLIQKLQNERENDPTHIQLREEVSTWNSRILKRTAITICGFGFLLFICKLTFQRK 475
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 97.8 bits (242), Expect = 2e-20
Identities = 74/214 (34%), Positives = 101/214 (47%), Gaps = 13/214 (6%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
GYLD L + + A+T G V +V+ LL+ G +++ + + G TPL
Sbjct: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 342
Query: 84 MYAASVANAELVRVLLDRGA--NASFEKDKQSILITAC-SAHGSEEQILKCVELLLSRNA 140
M AAS + E+ RVLLD GA N + K+S L AC H L V LL A
Sbjct: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH------LDMVRFLLEAGA 396
Query: 141 DPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLK 200
D + T +M A DGH +V LL+ GA+VN ++ + LT AA GH +
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
Query: 201 LLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
L+E GAN +G P A R H E+ LL
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALL 490
Score = 86.7 bits (213), Expect = 4e-17
Identities = 56/166 (33%), Positives = 90/166 (54%), Gaps = 14/166 (8%)
Query: 48 EKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA 103
+ F+ +T+ G V L L++ G +++ G+TPLM AA + E+V +LL +GA
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495
Query: 104 N--ASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGH 161
N A E+ +++ L AC SE + L+ AD + C TP+M A+++GH
Sbjct: 496 NINAQTEETQETALTLACCGGFSE-----VADFLIKAGADIELGCS---TPLMEASQEGH 547
Query: 162 TQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGAN 207
++V L+A GA V+ G TALT+A GH ++ LL+ GA+
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
Score = 78.2 bits (191), Expect = 2e-14
Identities = 54/155 (34%), Positives = 78/155 (50%), Gaps = 3/155 (1%)
Query: 52 KAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDK 111
+A + GDV+ V++LLD G SV+ + + G + L A S EL +VLL AN +K
Sbjct: 211 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270
Query: 112 QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAH 171
I ++ G L V+LLL +AD N T + YA G +V +L+
Sbjct: 271 GDITPLMAASSGG---YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Query: 172 GAEVNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
GA + +ENG+T L AA GH + LL+ GA
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
Score = 76.6 bits (187), Expect = 4e-14
Identities = 64/224 (28%), Positives = 97/224 (43%), Gaps = 39/224 (17%)
Query: 44 EEKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA 103
E K+ A G + +V+ LL++G + T LM A + E+ R+LLD GA
Sbjct: 370 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
Query: 104 NASFEKD--KQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGH 161
+ D + + + AC H ++ LL+ R A+ TP+M AAR+GH
Sbjct: 430 QVNMPADSFESPLTLAACGGH------VELAALLIERGANLEEVNDEGYTPLMEAAREGH 483
Query: 162 TQVVALLVAHGAEVNTQ-DENGYTALTWA------------------------------A 190
++VALL+A GA +N Q +E TALT A +
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEAS 543
Query: 191 RQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
++GH +V LL GAN T G A N H ++ ++L
Sbjct: 544 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 36.6 bits (83), Expect = 0.051
Identities = 21/59 (35%), Positives = 33/59 (55%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSIL 115
G + LV+ LL SG +V + G T L YA + ++ VLL GA+ ++D ++IL
Sbjct: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTIL 604
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 97.8 bits (242), Expect = 2e-20
Identities = 74/214 (34%), Positives = 101/214 (47%), Gaps = 13/214 (6%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
GYLD L + + A+T G V +V+ LL+ G +++ + + G TPL
Sbjct: 272 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 331
Query: 84 MYAASVANAELVRVLLDRGA--NASFEKDKQSILITAC-SAHGSEEQILKCVELLLSRNA 140
M AAS + E+ RVLLD GA N + K+S L AC H L V LL A
Sbjct: 332 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH------LDMVRFLLEAGA 385
Query: 141 DPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLK 200
D + T +M A DGH +V LL+ GA+VN ++ + LT AA GH +
Sbjct: 386 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 445
Query: 201 LLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
L+E GAN +G P A R H E+ LL
Sbjct: 446 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALL 479
Score = 86.7 bits (213), Expect = 4e-17
Identities = 56/166 (33%), Positives = 90/166 (54%), Gaps = 14/166 (8%)
Query: 48 EKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA 103
+ F+ +T+ G V L L++ G +++ G+TPLM AA + E+V +LL +GA
Sbjct: 425 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 484
Query: 104 N--ASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGH 161
N A E+ +++ L AC SE + L+ AD + C TP+M A+++GH
Sbjct: 485 NINAQTEETQETALTLACCGGFSE-----VADFLIKAGADIELGCS---TPLMEASQEGH 536
Query: 162 TQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGAN 207
++V L+A GA V+ G TALT+A GH ++ LL+ GA+
Sbjct: 537 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 582
Score = 78.2 bits (191), Expect = 2e-14
Identities = 54/155 (34%), Positives = 78/155 (50%), Gaps = 3/155 (1%)
Query: 52 KAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDK 111
+A + GDV+ V++LLD G SV+ + + G + L A S EL +VLL AN +K
Sbjct: 200 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 259
Query: 112 QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAH 171
I ++ G L V+LLL +AD N T + YA G +V +L+
Sbjct: 260 GDITPLMAASSGG---YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
Query: 172 GAEVNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
GA + +ENG+T L AA GH + LL+ GA
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
Score = 76.6 bits (187), Expect = 4e-14
Identities = 64/224 (28%), Positives = 97/224 (43%), Gaps = 39/224 (17%)
Query: 44 EEKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA 103
E K+ A G + +V+ LL++G + T LM A + E+ R+LLD GA
Sbjct: 359 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 418
Query: 104 NASFEKD--KQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGH 161
+ D + + + AC H ++ LL+ R A+ TP+M AAR+GH
Sbjct: 419 QVNMPADSFESPLTLAACGGH------VELAALLIERGANLEEVNDEGYTPLMEAAREGH 472
Query: 162 TQVVALLVAHGAEVNTQ-DENGYTALTWA------------------------------A 190
++VALL+A GA +N Q +E TALT A +
Sbjct: 473 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEAS 532
Query: 191 RQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
++GH +V LL GAN T G A N H ++ ++L
Sbjct: 533 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 576
Score = 36.6 bits (83), Expect = 0.051
Identities = 21/59 (35%), Positives = 33/59 (55%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSIL 115
G + LV+ LL SG +V + G T L YA + ++ VLL GA+ ++D ++IL
Sbjct: 535 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTIL 593
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 97.8 bits (242), Expect = 2e-20
Identities = 74/214 (34%), Positives = 101/214 (47%), Gaps = 13/214 (6%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
GYLD L + + A+T G V +V+ LL+ G +++ + + G TPL
Sbjct: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 342
Query: 84 MYAASVANAELVRVLLDRGA--NASFEKDKQSILITAC-SAHGSEEQILKCVELLLSRNA 140
M AAS + E+ RVLLD GA N + K+S L AC H L V LL A
Sbjct: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH------LDMVRFLLEAGA 396
Query: 141 DPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLK 200
D + T +M A DGH +V LL+ GA+VN ++ + LT AA GH +
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
Query: 201 LLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
L+E GAN +G P A R H E+ LL
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALL 490
Score = 92.4 bits (228), Expect = 8e-19
Identities = 61/186 (32%), Positives = 99/186 (53%), Gaps = 14/186 (7%)
Query: 48 EKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA 103
+ F+ +T+ G V L L++ G +++ G+TPLM AA + E+V +LL +GA
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495
Query: 104 N--ASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGH 161
N A E+ +++ L AC SE + L+ AD + C TP+M A+++GH
Sbjct: 496 NINAQTEETQETALTLACCGGFSE-----VADFLIKAGADIELGCS---TPLMEASQEGH 547
Query: 162 TQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEI 221
++V L+A GA V+ G TALT+A GH ++ LL+ GA+ +++ G+ P
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 607
Query: 222 AKRNKH 227
A R H
Sbjct: 608 AARAGH 613
Score = 78.2 bits (191), Expect = 2e-14
Identities = 54/155 (34%), Positives = 78/155 (50%), Gaps = 3/155 (1%)
Query: 52 KAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDK 111
+A + GDV+ V++LLD G SV+ + + G + L A S EL +VLL AN +K
Sbjct: 211 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270
Query: 112 QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAH 171
I ++ G L V+LLL +AD N T + YA G +V +L+
Sbjct: 271 GDITPLMAASSGG---YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Query: 172 GAEVNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
GA + +ENG+T L AA GH + LL+ GA
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
Score = 77.0 bits (188), Expect = 3e-14
Identities = 56/149 (37%), Positives = 77/149 (51%), Gaps = 6/149 (4%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSI 114
G +V LLD +V+ + G TPLM AAS AE+ RVLLD+GA NA +
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1294
Query: 115 LITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAE 174
+T + G K ELL+ R A +V ++ TP+ A+ GH VV LLV GA+
Sbjct: 1295 ALTIAADKGH----YKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
Query: 175 VNTQDENGYTALTWAARQGHKNIVLKLLE 203
V+ D T L A R+GH +V L++
Sbjct: 1351 VDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 76.6 bits (187), Expect = 4e-14
Identities = 64/224 (28%), Positives = 97/224 (43%), Gaps = 39/224 (17%)
Query: 44 EEKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA 103
E K+ A G + +V+ LL++G + T LM A + E+ R+LLD GA
Sbjct: 370 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
Query: 104 NASFEKD--KQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGH 161
+ D + + + AC H ++ LL+ R A+ TP+M AAR+GH
Sbjct: 430 QVNMPADSFESPLTLAACGGH------VELAALLIERGANLEEVNDEGYTPLMEAAREGH 483
Query: 162 TQVVALLVAHGAEVNTQ-DENGYTALTWA------------------------------A 190
++VALL+A GA +N Q +E TALT A +
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEAS 543
Query: 191 RQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
++GH +V LL GAN T G A N H ++ ++L
Sbjct: 544 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 73.9 bits (180), Expect = 3e-13
Identities = 65/215 (30%), Positives = 103/215 (47%), Gaps = 12/215 (5%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEK----FKKAMTIGDVSLVQELLDSGISVDSNFQYGW-TP 82
G+ + S + R IE + +K A T G V +V+ LLD G +++ + TP
Sbjct: 1066 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 1125
Query: 83 LMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADP 142
L A S E+V +LL RGAN ++ ++ G + +++LL+ A+
Sbjct: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG----YVNIIKILLNAGAEI 1181
Query: 143 N--VACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDE-NGYTALTWAARQGHKNIVL 199
N + ++P+M AA +GH V LL+ G+++N Q E N TALT A QG +V
Sbjct: 1182 NSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVS 1241
Query: 200 KLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
LL+ AN + K G P A + E+ +L
Sbjct: 1242 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276
Score = 69.3 bits (168), Expect = 7e-12
Identities = 61/200 (30%), Positives = 90/200 (45%), Gaps = 7/200 (3%)
Query: 45 EKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGW-TPLMYAASVANAELVRVLLDRGA 103
+ +E + A+T+ E+ D I ++ + G TPLM A+ + ELV+ LL GA
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGA 559
Query: 104 NASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQ 163
N +T +G + ++LL AD TP+M AAR GH
Sbjct: 560 NVHATTATGDTALTYACENGHTD----VADVLLQAGADLEHESEGGRTPLMKAARAGHLC 615
Query: 164 VVALLVAHGAEVNTQDENG-YTALTWAARQGHKNIVLKLLELGANKMLQTKDGK-MPSEI 221
V L++ GA VN N +T ++ A GH +V LL GA+ + KDG M E
Sbjct: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 675
Query: 222 AKRNKHHEIFNLLSFTLNPL 241
AK + + LL + N L
Sbjct: 676 AKGGHTNVVSYLLDYPNNVL 695
Score = 60.8 bits (146), Expect = 3e-09
Identities = 57/229 (24%), Positives = 97/229 (42%), Gaps = 44/229 (19%)
Query: 57 GDVSLVQELLDSGISVDSNF--QYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQ 112
G V++++ LL++G ++S + G +PLM AA + V++LLD G+ NA E ++
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIM------------------ 154
+ L AC +E V LLL R A+ + +TP+M
Sbjct: 1226 TALTLACFQGRAE-----VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG 1280
Query: 155 -----------------YAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNI 197
AA GH + LL+ GA ++ +++ G T L A+ GH ++
Sbjct: 1281 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV 1340
Query: 198 VLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQ 246
V L++ GA+ P A R H ++ L +N ++
Sbjct: 1341 VQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIE 1389
Score = 60.5 bits (145), Expect = 3e-09
Identities = 52/160 (32%), Positives = 75/160 (46%), Gaps = 13/160 (8%)
Query: 81 TPLMYAASVANAELVRVLLDRGANASFEKDKQS---ILITACSAHGSEEQILKCVELLLS 137
T L A + + ELV VL+ R A +DK+ +++ A + H + VE+LL
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIE-HRDKKGFTPLILAATAGH------VGVVEILLD 1109
Query: 138 RNADPNVACRRLM-TPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKN 196
+ D R TP+ A G +VV LL+A GA ++ + YT L+ AA G+ N
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVN 1169
Query: 197 IVLKLLELGA--NKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
I+ LL GA N +K G P +A N H LL
Sbjct: 1170 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 97.8 bits (242), Expect = 2e-20
Identities = 74/214 (34%), Positives = 101/214 (47%), Gaps = 13/214 (6%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
GYLD L + + A+T G V +V+ LL+ G +++ + + G TPL
Sbjct: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 342
Query: 84 MYAASVANAELVRVLLDRGA--NASFEKDKQSILITAC-SAHGSEEQILKCVELLLSRNA 140
M AAS + E+ RVLLD GA N + K+S L AC H L V LL A
Sbjct: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH------LDMVRFLLEAGA 396
Query: 141 DPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLK 200
D + T +M A DGH +V LL+ GA+VN ++ + LT AA GH +
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
Query: 201 LLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
L+E GAN +G P A R H E+ LL
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALL 490
Score = 92.4 bits (228), Expect = 8e-19
Identities = 61/186 (32%), Positives = 99/186 (53%), Gaps = 14/186 (7%)
Query: 48 EKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA 103
+ F+ +T+ G V L L++ G +++ G+TPLM AA + E+V +LL +GA
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495
Query: 104 N--ASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGH 161
N A E+ +++ L AC SE + L+ AD + C TP+M A+++GH
Sbjct: 496 NINAQTEETQETALTLACCGGFSE-----VADFLIKAGADIELGCS---TPLMEASQEGH 547
Query: 162 TQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEI 221
++V L+A GA V+ G TALT+A GH ++ LL+ GA+ +++ G+ P
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 607
Query: 222 AKRNKH 227
A R H
Sbjct: 608 AARAGH 613
Score = 78.2 bits (191), Expect = 2e-14
Identities = 54/155 (34%), Positives = 78/155 (50%), Gaps = 3/155 (1%)
Query: 52 KAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDK 111
+A + GDV+ V++LLD G SV+ + + G + L A S EL +VLL AN +K
Sbjct: 211 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270
Query: 112 QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAH 171
I ++ G L V+LLL +AD N T + YA G +V +L+
Sbjct: 271 GDITPLMAASSGG---YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Query: 172 GAEVNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
GA + +ENG+T L AA GH + LL+ GA
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
Score = 77.0 bits (188), Expect = 3e-14
Identities = 56/149 (37%), Positives = 77/149 (51%), Gaps = 6/149 (4%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSI 114
G +V LLD +V+ + G TPLM AAS AE+ RVLLD+GA NA +
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1294
Query: 115 LITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAE 174
+T + G K ELL+ R A +V ++ TP+ A+ GH VV LLV GA+
Sbjct: 1295 ALTIAADKGH----YKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
Query: 175 VNTQDENGYTALTWAARQGHKNIVLKLLE 203
V+ D T L A R+GH +V L++
Sbjct: 1351 VDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 76.6 bits (187), Expect = 4e-14
Identities = 64/224 (28%), Positives = 97/224 (43%), Gaps = 39/224 (17%)
Query: 44 EEKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA 103
E K+ A G + +V+ LL++G + T LM A + E+ R+LLD GA
Sbjct: 370 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
Query: 104 NASFEKD--KQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGH 161
+ D + + + AC H ++ LL+ R A+ TP+M AAR+GH
Sbjct: 430 QVNMPADSFESPLTLAACGGH------VELAALLIERGANLEEVNDEGYTPLMEAAREGH 483
Query: 162 TQVVALLVAHGAEVNTQ-DENGYTALTWA------------------------------A 190
++VALL+A GA +N Q +E TALT A +
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEAS 543
Query: 191 RQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
++GH +V LL GAN T G A N H ++ ++L
Sbjct: 544 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 73.9 bits (180), Expect = 3e-13
Identities = 65/215 (30%), Positives = 103/215 (47%), Gaps = 12/215 (5%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEK----FKKAMTIGDVSLVQELLDSGISVDSNFQYGW-TP 82
G+ + S + R IE + +K A T G V +V+ LLD G +++ + TP
Sbjct: 1066 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 1125
Query: 83 LMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADP 142
L A S E+V +LL RGAN ++ ++ G + +++LL+ A+
Sbjct: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG----YVNIIKILLNAGAEI 1181
Query: 143 N--VACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDE-NGYTALTWAARQGHKNIVL 199
N + ++P+M AA +GH V LL+ G+++N Q E N TALT A QG +V
Sbjct: 1182 NSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVS 1241
Query: 200 KLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
LL+ AN + K G P A + E+ +L
Sbjct: 1242 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276
Score = 69.3 bits (168), Expect = 7e-12
Identities = 61/200 (30%), Positives = 90/200 (45%), Gaps = 7/200 (3%)
Query: 45 EKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGW-TPLMYAASVANAELVRVLLDRGA 103
+ +E + A+T+ E+ D I ++ + G TPLM A+ + ELV+ LL GA
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGA 559
Query: 104 NASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQ 163
N +T +G + ++LL AD TP+M AAR GH
Sbjct: 560 NVHATTATGDTALTYACENGHTD----VADVLLQAGADLEHESEGGRTPLMKAARAGHLC 615
Query: 164 VVALLVAHGAEVNTQDENG-YTALTWAARQGHKNIVLKLLELGANKMLQTKDGK-MPSEI 221
V L++ GA VN N +T ++ A GH +V LL GA+ + KDG M E
Sbjct: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 675
Query: 222 AKRNKHHEIFNLLSFTLNPL 241
AK + + LL + N L
Sbjct: 676 AKGGHTNVVSYLLDYPNNVL 695
Score = 60.8 bits (146), Expect = 3e-09
Identities = 57/229 (24%), Positives = 97/229 (42%), Gaps = 44/229 (19%)
Query: 57 GDVSLVQELLDSGISVDSNF--QYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQ 112
G V++++ LL++G ++S + G +PLM AA + V++LLD G+ NA E ++
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIM------------------ 154
+ L AC +E V LLL R A+ + +TP+M
Sbjct: 1226 TALTLACFQGRAE-----VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG 1280
Query: 155 -----------------YAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNI 197
AA GH + LL+ GA ++ +++ G T L A+ GH ++
Sbjct: 1281 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV 1340
Query: 198 VLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQ 246
V L++ GA+ P A R H ++ L +N ++
Sbjct: 1341 VQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIE 1389
Score = 60.5 bits (145), Expect = 3e-09
Identities = 52/160 (32%), Positives = 75/160 (46%), Gaps = 13/160 (8%)
Query: 81 TPLMYAASVANAELVRVLLDRGANASFEKDKQS---ILITACSAHGSEEQILKCVELLLS 137
T L A + + ELV VL+ R A +DK+ +++ A + H + VE+LL
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIE-HRDKKGFTPLILAATAGH------VGVVEILLD 1109
Query: 138 RNADPNVACRRLM-TPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKN 196
+ D R TP+ A G +VV LL+A GA ++ + YT L+ AA G+ N
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVN 1169
Query: 197 IVLKLLELGA--NKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
I+ LL GA N +K G P +A N H LL
Sbjct: 1170 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 94.4 bits (233), Expect = 2e-19
Identities = 66/180 (36%), Positives = 93/180 (51%), Gaps = 31/180 (17%)
Query: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEK-DKQSILI 116
++ ++ LL+ VD + G TPLM AA N E+V+ L+ GAN + E D + LI
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 117 TACSAHGSE---EQILKC--------------------------VELLLSRNADPNVACR 147
+A S G E++LKC VELLLS A+P+V
Sbjct: 77 SA-SKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
Query: 148 RLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGAN 207
+ PI++AA GH +V LL+ +GA+VN D+ G T L WAAR+GH V LL +GA+
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
Score = 90.9 bits (224), Expect = 2e-18
Identities = 59/174 (33%), Positives = 87/174 (50%), Gaps = 4/174 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V +V+ELL G++++ GWT LM+A ++V +LL GAN S I
Sbjct: 82 GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+ G + V LLL A N + + TP+++AAR GH + V L+A GA+V+
Sbjct: 142 IWAAGRGHAD----IVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD 197
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEI 230
+ N TAL A + G+ V ++L+ N L KDG IA + H EI
Sbjct: 198 QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEI 251
Score = 73.9 bits (180), Expect = 3e-13
Identities = 58/212 (27%), Positives = 97/212 (45%), Gaps = 39/212 (18%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFE-KDKQSIL 115
G +V LL +G V+ + +YG TPL++AA + E V+ LL GA+ E + + L
Sbjct: 148 GHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTAL 207
Query: 116 ITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEV 175
I A ++ V+ +L RN + N+ + T +M A+++GHT++V L+ G V
Sbjct: 208 IVAVKGGYTQS-----VKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYV 262
Query: 176 NTQDENG---------------------------------YTALTWAARQGHKNIVLKLL 202
N D +G TAL WA +G+ +V +L
Sbjct: 263 NIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDIL 322
Query: 203 ELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+ + + TKDG+ P A + ++ E+ LL
Sbjct: 323 QCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
Score = 58.2 bits (139), Expect = 2e-08
Identities = 32/95 (33%), Positives = 56/95 (58%)
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
S+LI+ + EE+ + ++ LL + D + TP+M AA G+ ++V L+ +G
Sbjct: 2 SVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNG 61
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLKLLELGAN 207
A N +D + +TAL A+++GH +IV +LL+ G N
Sbjct: 62 ANCNLEDLDNWTALISASKEGHVHIVEELLKCGVN 96
Score = 55.1 bits (131), Expect = 1e-07
Identities = 54/195 (27%), Positives = 88/195 (45%), Gaps = 17/195 (8%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
GY + LKR + + A+ I G +VQ+LLD+G V+ + G T L
Sbjct: 214 GYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVL 273
Query: 84 MYAASVANAELVRVLLDRGANASFE-KDKQSILITACSAHGSEEQILKCVELLLSRNADP 142
+ A + E+VR LL + A+ +D ++ L A E+ V +L N D
Sbjct: 274 IGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAV-----EKGNATMVRDILQCNPDT 328
Query: 143 NVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLL 202
+ + TP++ A + + +VV LL+ GA+V+ D+ G T L A R + + LL
Sbjct: 329 EICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLL 388
Query: 203 ELGANKMLQTKDGKM 217
KDG++
Sbjct: 389 R-------NPKDGRL 396
Score = 37.0 bits (84), Expect = 0.039
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 4/104 (3%)
Query: 44 EEKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA 103
++ K A+ G+ ++V+++L + + G TPL+ A + N E+V +LLD+GA
Sbjct: 300 QDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGA 359
Query: 104 NASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACR 147
S DK+ + G K ELLL D + R
Sbjct: 360 KVS-AVDKKGDTPLHIAIRGRSR---KLAELLLRNPKDGRLLYR 399
Score = 32.3 bits (72), Expect = 0.96
Identities = 23/67 (34%), Positives = 35/67 (52%), Gaps = 1/67 (1%)
Query: 174 EVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKH-HEIFN 232
+V+ ++E G T L AA QG+ IV +L++ GAN L+ D A + H H +
Sbjct: 30 DVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEE 89
Query: 233 LLSFTLN 239
LL +N
Sbjct: 90 LLKCGVN 96
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 94.4 bits (233), Expect = 2e-19
Identities = 62/186 (33%), Positives = 99/186 (53%), Gaps = 14/186 (7%)
Query: 48 EKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA 103
+ F+ +T+ G V L L++ G S++ G+TPLM AA + E+V +LL +GA
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524
Query: 104 --NASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGH 161
NA E+ +++ L AC L+ + L+ AD + C TP+M AA++GH
Sbjct: 525 NINAQTEETQETALTLACCG-----GFLEVADFLIKAGADIELGC---STPLMEAAQEGH 576
Query: 162 TQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEI 221
++V L+A GA V+ G TALT+A GH ++ LL+ GA+ +++ G+ P
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
Query: 222 AKRNKH 227
A R H
Sbjct: 637 AARAGH 642
Score = 93.2 bits (230), Expect = 5e-19
Identities = 65/181 (35%), Positives = 92/181 (50%), Gaps = 9/181 (4%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSI 114
G V +V+ LL+SG S++ + + G TPLM A S + E+ R+LL+ GA N + K+S
Sbjct: 345 GYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESA 404
Query: 115 LITAC-SAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGA 173
L AC H L+ V LL AD + T +M A DGH +V LL+ GA
Sbjct: 405 LTLACYKGH------LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 458
Query: 174 EVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNL 233
+VN ++ + LT AA GH + L+E GA+ +G P A R H E+ L
Sbjct: 459 QVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVAL 518
Query: 234 L 234
L
Sbjct: 519 L 519
Score = 82.8 bits (203), Expect = 6e-16
Identities = 56/155 (36%), Positives = 87/155 (56%), Gaps = 9/155 (5%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGAN--ASFEKDKQSI 114
G LVQ LL+ G S++ + G+TPL+ AA+ + +V +LLD GA+ A E+ K +
Sbjct: 1094 GHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 1153
Query: 115 LITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAE 174
L ACS G +++ VELLL+R A+ TP+ AA G+ ++ +L+ GAE
Sbjct: 1154 LSLACS--GGRQEV---VELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 1208
Query: 175 VN--TQDENGYTALTWAARQGHKNIVLKLLELGAN 207
+N T + G + L AA GH V LL++G++
Sbjct: 1209 INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSD 1243
Score = 79.3 bits (194), Expect = 7e-15
Identities = 55/155 (35%), Positives = 78/155 (50%), Gaps = 3/155 (1%)
Query: 52 KAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDK 111
+A + GDV+ V++LL G SV+ + + G + L A S EL +VLL AN K
Sbjct: 240 EACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIK 299
Query: 112 QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAH 171
I +A+G +K V+LLL+ AD N T + YA G+ VV +L+
Sbjct: 300 GDITPLMAAANGGH---VKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
Query: 172 GAEVNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
GA + +ENG+T L A GH + LLE GA
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGA 391
Score = 79.0 bits (193), Expect = 9e-15
Identities = 57/149 (38%), Positives = 77/149 (51%), Gaps = 6/149 (4%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSI 114
G +V LLD +V+ + G TPLM AAS AE+ RVLLD+GA NA +
Sbjct: 1263 GRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1322
Query: 115 LITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAE 174
+T + G K ELL+ R A +V ++ TP+ AA GH VV LLV GA+
Sbjct: 1323 ALTIAADKGH----YKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1378
Query: 175 VNTQDENGYTALTWAARQGHKNIVLKLLE 203
V+ D T L A R+GH +V L++
Sbjct: 1379 VDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 74.3 bits (181), Expect = 2e-13
Identities = 57/156 (36%), Positives = 83/156 (53%), Gaps = 11/156 (7%)
Query: 83 LMYAASVANAELVRVLLDRGANASFEKDK-QSILITACSAHGSEEQILKCVELLLSRNAD 141
L A S + VR LL G + + ++ +S+L ACSA E ++LL+ +A
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYE-----LAQVLLAMHA- 291
Query: 142 PNVACRRL---MTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIV 198
NV R + +TP+M AA GH ++V LL+AH A+VN Q G TALT+A G+ ++V
Sbjct: 292 -NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVV 350
Query: 199 LKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
LLE GA+ ++G P A H E+ LL
Sbjct: 351 KVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
Score = 72.8 bits (177), Expect = 6e-13
Identities = 65/209 (31%), Positives = 93/209 (44%), Gaps = 7/209 (3%)
Query: 45 EKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGW-TPLMYAASVANAELVRVLLDRGA 103
+ +E + A+T+ E+ D I ++ + G TPLM AA + ELV+ LL GA
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGA 588
Query: 104 NASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQ 163
N +T +G + ++LL AD TP+M AAR GH
Sbjct: 589 NVHATTATGDTALTYACENGHTD----VADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644
Query: 164 VVALLVAHGAEVN-TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGK-MPSEI 221
V L++ GA VN T N +T L+ A GH +V LL GA+ + KDG M E
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 704
Query: 222 AKRNKHHEIFNLLSFTLNPLEGKLQQLTK 250
AK + LL + N L +T+
Sbjct: 705 AKGGHTSVVCYLLDYPNNLLSAPPPDVTQ 733
Score = 68.2 bits (165), Expect = 2e-11
Identities = 83/345 (24%), Positives = 141/345 (40%), Gaps = 59/345 (17%)
Query: 57 GDVSLVQELLDSGISVDSNF--QYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQ 112
G V++++ LL++G ++S + G +PLM AA + V++LLD G+ NA E ++
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQV-------- 164
+ L AC +E V LLL R A+ + +TP+M AA G+ +V
Sbjct: 1254 TALTLACFQGRTE-----VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG 1308
Query: 165 ---------------------------VALLVAHGAEVNTQDENGYTALTWAARQGHKNI 197
LL+ GA ++ +++ G T L AA GH ++
Sbjct: 1309 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDV 1368
Query: 198 VLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQQLTKEDTICKI 257
V L++ GA+ P A R H ++ L +N Q + +
Sbjct: 1369 VQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN-------QFPSDSECMRY 1421
Query: 258 LTTDSDRE---KDHI-FSSYTAFGD---LEVFLHGLGLEHMTDLLKERDITLR-HLLTMR 309
+ T +D+E K H+ S D E + L DL K R+ + R L R
Sbjct: 1422 IATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKR 1481
Query: 310 EDEFTKNGITSKDQQKILAALKELQVEEIQFGELSEETKLEISGD 354
E K ++Q++ L ++ E + E+ KL++ +
Sbjct: 1482 EKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDE 1526
Score = 67.0 bits (162), Expect = 4e-11
Identities = 57/175 (32%), Positives = 83/175 (47%), Gaps = 16/175 (9%)
Query: 66 LDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQS---ILITACSAH 122
+D +SN T L A + + ELV+ LL+RGA+ +DK+ +++ A + H
Sbjct: 1073 IDIDAQTESNHD---TALTLACAGGHEELVQTLLERGASIE-HRDKKGFTPLILAATAGH 1128
Query: 123 GSEEQILKCVELLLSRNADPNVACRRLM-TPIMYAARDGHTQVVALLVAHGAEVNTQDEN 181
+ VE+LL AD R TP+ A G +VV LL+A GA ++ +
Sbjct: 1129 ------VGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 1182
Query: 182 GYTALTWAARQGHKNIVLKLLELGA--NKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
YT L+ AA G+ NI+ LL GA N +K G P +A N H LL
Sbjct: 1183 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 1237
Score = 56.6 bits (135), Expect = 5e-08
Identities = 79/327 (24%), Positives = 138/327 (42%), Gaps = 38/327 (11%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANAS--FEKDKQSI 114
G + LL +G ++ + G TPLM AA + V+ L+ +GAN + + ++
Sbjct: 608 GHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTV 667
Query: 115 LITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAE 174
L AC+ L VELLL+ ADP + T ++ AA+ GHT VV L+ +
Sbjct: 668 LSLACAGGH-----LAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722
Query: 175 VNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAK----RNK---H 227
+ + T LT + ++ + + L Q D K P+ +A RNK
Sbjct: 723 LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPD-KPPANVATTLPIRNKAASK 781
Query: 228 HEIFNLLSFTLNPLEGKLQQLTKEDTICKI---LTTDSDREKDHIFSSYTAFGDLEVFLH 284
+ + L ++G + + E + + LT R K+ I + L
Sbjct: 782 QKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAI--------EKNAQLQ 833
Query: 285 GLGLEHMTDLLKERDITLRHLLTMREDEFTKNGITSKDQQKILAALKELQVE-EIQFGEL 343
L L H L KE+ + L RE++ K +QKIL L++++ E +++ +
Sbjct: 834 SLELAHADQLTKEK---IEELNKTREEQIQK-------KQKILEELQKVERELQLKTQQQ 883
Query: 344 SEETKLEISGDEFLNFLLKLNKQCGHL 370
++ LE+ + + + C HL
Sbjct: 884 LKKQYLEVKAQR-IQLQQQQQQSCQHL 909
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 94.4 bits (233), Expect = 2e-19
Identities = 62/186 (33%), Positives = 99/186 (53%), Gaps = 14/186 (7%)
Query: 48 EKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA 103
+ F+ +T+ G V L L++ G S++ G+TPLM AA + E+V +LL +GA
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524
Query: 104 --NASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGH 161
NA E+ +++ L AC L+ + L+ AD + C TP+M AA++GH
Sbjct: 525 NINAQTEETQETALTLACCG-----GFLEVADFLIKAGADIELGC---STPLMEAAQEGH 576
Query: 162 TQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEI 221
++V L+A GA V+ G TALT+A GH ++ LL+ GA+ +++ G+ P
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
Query: 222 AKRNKH 227
A R H
Sbjct: 637 AARAGH 642
Score = 93.2 bits (230), Expect = 5e-19
Identities = 65/181 (35%), Positives = 92/181 (50%), Gaps = 9/181 (4%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSI 114
G V +V+ LL+SG S++ + + G TPLM A S + E+ R+LL+ GA N + K+S
Sbjct: 345 GYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESA 404
Query: 115 LITAC-SAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGA 173
L AC H L+ V LL AD + T +M A DGH +V LL+ GA
Sbjct: 405 LTLACYKGH------LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 458
Query: 174 EVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNL 233
+VN ++ + LT AA GH + L+E GA+ +G P A R H E+ L
Sbjct: 459 QVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVAL 518
Query: 234 L 234
L
Sbjct: 519 L 519
Score = 82.8 bits (203), Expect = 6e-16
Identities = 56/155 (36%), Positives = 87/155 (56%), Gaps = 9/155 (5%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGAN--ASFEKDKQSI 114
G LVQ LL+ G S++ + G+TPL+ AA+ + +V +LLD GA+ A E+ K +
Sbjct: 843 GHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 902
Query: 115 LITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAE 174
L ACS G +++ VELLL+R A+ TP+ AA G+ ++ +L+ GAE
Sbjct: 903 LSLACS--GGRQEV---VELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 957
Query: 175 VN--TQDENGYTALTWAARQGHKNIVLKLLELGAN 207
+N T + G + L AA GH V LL++G++
Sbjct: 958 INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSD 992
Score = 79.3 bits (194), Expect = 7e-15
Identities = 55/155 (35%), Positives = 78/155 (50%), Gaps = 3/155 (1%)
Query: 52 KAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDK 111
+A + GDV+ V++LL G SV+ + + G + L A S EL +VLL AN K
Sbjct: 240 EACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIK 299
Query: 112 QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAH 171
I +A+G +K V+LLL+ AD N T + YA G+ VV +L+
Sbjct: 300 GDITPLMAAANGGH---VKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
Query: 172 GAEVNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
GA + +ENG+T L A GH + LLE GA
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGA 391
Score = 79.0 bits (193), Expect = 9e-15
Identities = 57/149 (38%), Positives = 77/149 (51%), Gaps = 6/149 (4%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSI 114
G +V LLD +V+ + G TPLM AAS AE+ RVLLD+GA NA +
Sbjct: 1012 GRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1071
Query: 115 LITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAE 174
+T + G K ELL+ R A +V ++ TP+ AA GH VV LLV GA+
Sbjct: 1072 ALTIAADKGH----YKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1127
Query: 175 VNTQDENGYTALTWAARQGHKNIVLKLLE 203
V+ D T L A R+GH +V L++
Sbjct: 1128 VDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 74.3 bits (181), Expect = 2e-13
Identities = 57/156 (36%), Positives = 83/156 (53%), Gaps = 11/156 (7%)
Query: 83 LMYAASVANAELVRVLLDRGANASFEKDK-QSILITACSAHGSEEQILKCVELLLSRNAD 141
L A S + VR LL G + + ++ +S+L ACSA E ++LL+ +A
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYE-----LAQVLLAMHA- 291
Query: 142 PNVACRRL---MTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIV 198
NV R + +TP+M AA GH ++V LL+AH A+VN Q G TALT+A G+ ++V
Sbjct: 292 -NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVV 350
Query: 199 LKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
LLE GA+ ++G P A H E+ LL
Sbjct: 351 KVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
Score = 72.8 bits (177), Expect = 6e-13
Identities = 65/209 (31%), Positives = 93/209 (44%), Gaps = 7/209 (3%)
Query: 45 EKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGW-TPLMYAASVANAELVRVLLDRGA 103
+ +E + A+T+ E+ D I ++ + G TPLM AA + ELV+ LL GA
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGA 588
Query: 104 NASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQ 163
N +T +G + ++LL AD TP+M AAR GH
Sbjct: 589 NVHATTATGDTALTYACENGHTD----VADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644
Query: 164 VVALLVAHGAEVN-TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGK-MPSEI 221
V L++ GA VN T N +T L+ A GH +V LL GA+ + KDG M E
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 704
Query: 222 AKRNKHHEIFNLLSFTLNPLEGKLQQLTK 250
AK + LL + N L +T+
Sbjct: 705 AKGGHTSVVCYLLDYPNNLLSAPPPDVTQ 733
Score = 68.2 bits (165), Expect = 2e-11
Identities = 83/345 (24%), Positives = 141/345 (40%), Gaps = 59/345 (17%)
Query: 57 GDVSLVQELLDSGISVDSNF--QYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQ 112
G V++++ LL++G ++S + G +PLM AA + V++LLD G+ NA E ++
Sbjct: 943 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1002
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQV-------- 164
+ L AC +E V LLL R A+ + +TP+M AA G+ +V
Sbjct: 1003 TALTLACFQGRTE-----VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG 1057
Query: 165 ---------------------------VALLVAHGAEVNTQDENGYTALTWAARQGHKNI 197
LL+ GA ++ +++ G T L AA GH ++
Sbjct: 1058 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDV 1117
Query: 198 VLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQQLTKEDTICKI 257
V L++ GA+ P A R H ++ L +N Q + +
Sbjct: 1118 VQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN-------QFPSDSECMRY 1170
Query: 258 LTTDSDRE---KDHI-FSSYTAFGD---LEVFLHGLGLEHMTDLLKERDITLR-HLLTMR 309
+ T +D+E K H+ S D E + L DL K R+ + R L R
Sbjct: 1171 IATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKR 1230
Query: 310 EDEFTKNGITSKDQQKILAALKELQVEEIQFGELSEETKLEISGD 354
E K ++Q++ L ++ E + E+ KL++ +
Sbjct: 1231 EKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDE 1275
Score = 67.0 bits (162), Expect = 4e-11
Identities = 57/175 (32%), Positives = 83/175 (47%), Gaps = 16/175 (9%)
Query: 66 LDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQS---ILITACSAH 122
+D +SN T L A + + ELV+ LL+RGA+ +DK+ +++ A + H
Sbjct: 822 IDIDAQTESNHD---TALTLACAGGHEELVQTLLERGASIE-HRDKKGFTPLILAATAGH 877
Query: 123 GSEEQILKCVELLLSRNADPNVACRRLM-TPIMYAARDGHTQVVALLVAHGAEVNTQDEN 181
+ VE+LL AD R TP+ A G +VV LL+A GA ++ +
Sbjct: 878 ------VGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 931
Query: 182 GYTALTWAARQGHKNIVLKLLELGA--NKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
YT L+ AA G+ NI+ LL GA N +K G P +A N H LL
Sbjct: 932 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986
Score = 54.7 bits (130), Expect = 2e-07
Identities = 40/133 (30%), Positives = 63/133 (47%), Gaps = 7/133 (5%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANAS--FEKDKQSI 114
G + LL +G ++ + G TPLM AA + V+ L+ +GAN + + ++
Sbjct: 608 GHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTV 667
Query: 115 LITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAE 174
L AC+ L VELLL+ ADP + T ++ AA+ GHT VV L+ +
Sbjct: 668 LSLACAGGH-----LAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722
Query: 175 VNTQDENGYTALT 187
+ + T LT
Sbjct: 723 LLSAPPPDVTQLT 735
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 88.2 bits (217), Expect = 1e-17
Identities = 62/173 (35%), Positives = 86/173 (49%), Gaps = 4/173 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G + + LLD G +S G+TPL A + ++ +LL GA+ + +
Sbjct: 382 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
S G L V+ LL R A PNV+ ++ TP+ AAR GHT+V L+ + A+VN
Sbjct: 442 HVASFMGH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 497
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHE 229
+ ++ T L AAR GH N+V LLE AN L T G P IA R H E
Sbjct: 498 AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 550
Score = 84.0 bits (206), Expect = 3e-16
Identities = 58/176 (32%), Positives = 87/176 (49%), Gaps = 4/176 (2%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITA 118
V +++ LL +G S+D+ + G TPL A+ + + +V+ LL RGA+ + K +
Sbjct: 417 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 476
Query: 119 CSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
+ G E + LL A N + TP+ AAR GHT +V LL+ + A N
Sbjct: 477 AARAGHTE----VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 532
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
G+T L AAR+GH VL LLE A++ TK G P +A + + LL
Sbjct: 533 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 588
Score = 83.6 bits (205), Expect = 4e-16
Identities = 67/246 (27%), Positives = 110/246 (44%), Gaps = 29/246 (11%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
G++ + L + + +E +K A+ I G +V+EL++ G +V++ Q G+TPL
Sbjct: 89 GHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 148
Query: 84 MYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVE---------- 133
AA + E+V+ LL+ GAN + + + G E + +
Sbjct: 149 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 208
Query: 134 ---------------LLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
+LL + +P+V + TP+ AA + V LL+ GA VN
Sbjct: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTL 238
+NG T L A+R+G+ +V LL+ GA +TKD P A RN H I +L
Sbjct: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328
Query: 239 NPLEGK 244
P++ K
Sbjct: 329 APIQAK 334
Score = 81.3 bits (199), Expect = 2e-15
Identities = 69/249 (27%), Positives = 110/249 (44%), Gaps = 41/249 (16%)
Query: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILIT 117
++ +V+ LL G S S G+TPL AA E+ R LL G +A+ E + +
Sbjct: 614 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 673
Query: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG----- 172
+ G E V LLLS+ A+ N+ + +TP+ A++GH V +L+ HG
Sbjct: 674 LAAQEGHAEM----VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 729
Query: 173 ----------------------------AEVNTQDENGYTALTWAARQGHKNIVLKLLEL 204
A+VN + + GY+ L AA+QGH +IV LL+
Sbjct: 730 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 789
Query: 205 GANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNP----LEGKLQQLTKEDTICKILTT 260
GA+ + DG P IAKR + + ++L + L +++ +T+ +IL
Sbjct: 790 GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDV 849
Query: 261 DSDREKDHI 269
D HI
Sbjct: 850 SEDEGTAHI 858
Score = 79.0 bits (193), Expect = 9e-15
Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 4/182 (2%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A IG ++V+ LL++ + + G TPL AA + E V LL++ A+ + K
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
+ + +G ++ ELLL R+A PN A + +TP+ A + +V LL+ G
Sbjct: 570 FTPLHVAAKYGK----VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFN 232
++ NGYT L AA+Q + LL+ G + ++ G P +A + H E+
Sbjct: 626 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 685
Query: 233 LL 234
LL
Sbjct: 686 LL 687
Score = 76.3 bits (186), Expect = 6e-14
Identities = 52/177 (29%), Positives = 84/177 (47%), Gaps = 4/177 (2%)
Query: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILIT 117
D LL + + D + G+TPL AA N + ++LL+RGA+ +F +
Sbjct: 218 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 277
Query: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNT 177
S G+ + V LLL R A + +TP+ AAR+GH ++ +L+ HGA +
Sbjct: 278 IASRRGN----VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333
Query: 178 QDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+ +NG + + AA+ H + V LL+ A T D P +A HH + +L
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 390
Score = 70.5 bits (171), Expect = 3e-12
Identities = 51/178 (28%), Positives = 83/178 (46%), Gaps = 4/178 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V + + LLD G + + + G +P+ AA + + VR+LL A + +
Sbjct: 316 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTP 374
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+AH ++ K +LL + A PN TP+ A + H +V+ LL+ GA ++
Sbjct: 375 LHVAAHCGHHRVAK---VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
E+G T L A+ GH IV LL+ GA+ + + P +A R H E+ L
Sbjct: 432 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Score = 64.7 bits (156), Expect = 2e-10
Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 19/188 (10%)
Query: 111 KQSILITACSAHG-------SEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQ 163
+ + I C+ +G S+E +K V LL + ++ T + AA G +
Sbjct: 66 RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDE 125
Query: 164 VVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAK 223
VV LV +GA VN Q + G+T L AA++ H +V LLE GAN+ + T+DG P +A
Sbjct: 126 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 185
Query: 224 RNKHHEIFNLLSFTLN-PLEGKLQ------QLTKEDTICKILTTDSDREKDHIFSSYTAF 276
+ H N+++ +N +GK++ +DT + +D D + S T F
Sbjct: 186 QQGHE---NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL--SKTGF 240
Query: 277 GDLEVFLH 284
L + H
Sbjct: 241 TPLHIAAH 248
Score = 52.4 bits (124), Expect = 9e-07
Identities = 40/148 (27%), Positives = 62/148 (41%), Gaps = 39/148 (26%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V + L+ G+ VD+ + G+TPL A+ N +LV+
Sbjct: 712 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK-------------------- 751
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
LL AD N + +P+ AA+ GHT +V LL+ +GA N
Sbjct: 752 -----------------FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Query: 177 TQDENGYTALTWAARQGHKNI--VLKLL 202
+G T L A R G+ ++ VLK++
Sbjct: 795 EVSSDGTTPLAIAKRLGYISVTDVLKVV 822
Score = 38.5 bits (88), Expect = 0.013
Identities = 22/72 (30%), Positives = 36/72 (50%)
Query: 151 TPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKML 210
T + AAR G+ + +G ++NT ++NG L A+++GH +V++LL
Sbjct: 47 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106
Query: 211 QTKDGKMPSEIA 222
TK G IA
Sbjct: 107 TTKKGNTALHIA 118
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 88.2 bits (217), Expect = 1e-17
Identities = 62/173 (35%), Positives = 86/173 (49%), Gaps = 4/173 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G + + LLD G +S G+TPL A + ++ +LL GA+ + +
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
S G L V+ LL R A PNV+ ++ TP+ AAR GHT+V L+ + A+VN
Sbjct: 409 HVASFMGH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHE 229
+ ++ T L AAR GH N+V LLE AN L T G P IA R H E
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Score = 84.0 bits (206), Expect = 3e-16
Identities = 58/176 (32%), Positives = 87/176 (49%), Gaps = 4/176 (2%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITA 118
V +++ LL +G S+D+ + G TPL A+ + + +V+ LL RGA+ + K +
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 119 CSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
+ G E + LL A N + TP+ AAR GHT +V LL+ + A N
Sbjct: 444 AARAGHTE----VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
G+T L AAR+GH VL LLE A++ TK G P +A + + LL
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 83.6 bits (205), Expect = 4e-16
Identities = 67/246 (27%), Positives = 110/246 (44%), Gaps = 29/246 (11%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
G++ + L + + +E +K A+ I G +V+EL++ G +V++ Q G+TPL
Sbjct: 56 GHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115
Query: 84 MYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVE---------- 133
AA + E+V+ LL+ GAN + + + G E + +
Sbjct: 116 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 175
Query: 134 ---------------LLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
+LL + +P+V + TP+ AA + V LL+ GA VN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTL 238
+NG T L A+R+G+ +V LL+ GA +TKD P A RN H I +L
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 239 NPLEGK 244
P++ K
Sbjct: 296 APIQAK 301
Score = 79.3 bits (194), Expect = 7e-15
Identities = 68/249 (27%), Positives = 111/249 (44%), Gaps = 41/249 (16%)
Query: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILIT 117
++ +V+ LL G S S G+TPL AA E+ R LL G +A+ E + +
Sbjct: 581 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640
Query: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG----- 172
+ G E V LLLS+ A+ N+ + +TP+ A++GH V +L+ HG
Sbjct: 641 LAAQEGHAEM----VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 173 ----------------------------AEVNTQDENGYTALTWAARQGHKNIVLKLLEL 204
A+VN + + GY+ L AA+QGH +IV LL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 205 GANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNP----LEGKLQQLTKEDTICKILTT 260
GA+ + DG P IAKR + + ++L + L +++ +T+ +IL
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDV 816
Query: 261 DSDREKDHI 269
D ++ I
Sbjct: 817 SEDEGEELI 825
Score = 79.0 bits (193), Expect = 9e-15
Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 4/182 (2%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A IG ++V+ LL++ + + G TPL AA + E V LL++ A+ + K
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
+ + +G ++ ELLL R+A PN A + +TP+ A + +V LL+ G
Sbjct: 537 FTPLHVAAKYGK----VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFN 232
++ NGYT L AA+Q + LL+ G + ++ G P +A + H E+
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 233 LL 234
LL
Sbjct: 653 LL 654
Score = 76.3 bits (186), Expect = 6e-14
Identities = 52/177 (29%), Positives = 84/177 (47%), Gaps = 4/177 (2%)
Query: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILIT 117
D LL + + D + G+TPL AA N + ++LL+RGA+ +F +
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNT 177
S G+ + V LLL R A + +TP+ AAR+GH ++ +L+ HGA +
Sbjct: 245 IASRRGN----VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 178 QDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+ +NG + + AA+ H + V LL+ A T D P +A HH + +L
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 70.5 bits (171), Expect = 3e-12
Identities = 51/178 (28%), Positives = 83/178 (46%), Gaps = 4/178 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V + + LLD G + + + G +P+ AA + + VR+LL A + +
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTP 341
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+AH ++ K +LL + A PN TP+ A + H +V+ LL+ GA ++
Sbjct: 342 LHVAAHCGHHRVAK---VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
E+G T L A+ GH IV LL+ GA+ + + P +A R H E+ L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 64.7 bits (156), Expect = 2e-10
Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 19/188 (10%)
Query: 111 KQSILITACSAHG-------SEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQ 163
+ + I C+ +G S+E +K V LL + ++ T + AA G +
Sbjct: 33 RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDE 92
Query: 164 VVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAK 223
VV LV +GA VN Q + G+T L AA++ H +V LLE GAN+ + T+DG P +A
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 224 RNKHHEIFNLLSFTLN-PLEGKLQ------QLTKEDTICKILTTDSDREKDHIFSSYTAF 276
+ H N+++ +N +GK++ +DT + +D D + S T F
Sbjct: 153 QQGHE---NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL--SKTGF 207
Query: 277 GDLEVFLH 284
L + H
Sbjct: 208 TPLHIAAH 215
Score = 52.4 bits (124), Expect = 9e-07
Identities = 40/148 (27%), Positives = 62/148 (41%), Gaps = 39/148 (26%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V + L+ G+ VD+ + G+TPL A+ N +LV+
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK-------------------- 718
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
LL AD N + +P+ AA+ GHT +V LL+ +GA N
Sbjct: 719 -----------------FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 177 TQDENGYTALTWAARQGHKNI--VLKLL 202
+G T L A R G+ ++ VLK++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKVV 789
Score = 38.5 bits (88), Expect = 0.013
Identities = 22/72 (30%), Positives = 36/72 (50%)
Query: 151 TPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKML 210
T + AAR G+ + +G ++NT ++NG L A+++GH +V++LL
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 211 QTKDGKMPSEIA 222
TK G IA
Sbjct: 74 TTKKGNTALHIA 85
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 88.2 bits (217), Expect = 1e-17
Identities = 62/173 (35%), Positives = 86/173 (49%), Gaps = 4/173 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G + + LLD G +S G+TPL A + ++ +LL GA+ + +
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
S G L V+ LL R A PNV+ ++ TP+ AAR GHT+V L+ + A+VN
Sbjct: 409 HVASFMGH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHE 229
+ ++ T L AAR GH N+V LLE AN L T G P IA R H E
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Score = 84.0 bits (206), Expect = 3e-16
Identities = 58/176 (32%), Positives = 87/176 (49%), Gaps = 4/176 (2%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITA 118
V +++ LL +G S+D+ + G TPL A+ + + +V+ LL RGA+ + K +
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 119 CSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
+ G E + LL A N + TP+ AAR GHT +V LL+ + A N
Sbjct: 444 AARAGHTE----VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
G+T L AAR+GH VL LLE A++ TK G P +A + + LL
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 83.6 bits (205), Expect = 4e-16
Identities = 67/246 (27%), Positives = 110/246 (44%), Gaps = 29/246 (11%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
G++ + L + + +E +K A+ I G +V+EL++ G +V++ Q G+TPL
Sbjct: 56 GHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115
Query: 84 MYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVE---------- 133
AA + E+V+ LL+ GAN + + + G E + +
Sbjct: 116 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 175
Query: 134 ---------------LLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
+LL + +P+V + TP+ AA + V LL+ GA VN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTL 238
+NG T L A+R+G+ +V LL+ GA +TKD P A RN H I +L
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 239 NPLEGK 244
P++ K
Sbjct: 296 APIQAK 301
Score = 79.3 bits (194), Expect = 7e-15
Identities = 68/249 (27%), Positives = 111/249 (44%), Gaps = 41/249 (16%)
Query: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILIT 117
++ +V+ LL G S S G+TPL AA E+ R LL G +A+ E + +
Sbjct: 581 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640
Query: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG----- 172
+ G E V LLLS+ A+ N+ + +TP+ A++GH V +L+ HG
Sbjct: 641 LAAQEGHAEM----VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 173 ----------------------------AEVNTQDENGYTALTWAARQGHKNIVLKLLEL 204
A+VN + + GY+ L AA+QGH +IV LL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 205 GANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNP----LEGKLQQLTKEDTICKILTT 260
GA+ + DG P IAKR + + ++L + L +++ +T+ +IL
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDV 816
Query: 261 DSDREKDHI 269
D ++ I
Sbjct: 817 SEDEGEELI 825
Score = 79.0 bits (193), Expect = 9e-15
Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 4/182 (2%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A IG ++V+ LL++ + + G TPL AA + E V LL++ A+ + K
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
+ + +G ++ ELLL R+A PN A + +TP+ A + +V LL+ G
Sbjct: 537 FTPLHVAAKYGK----VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFN 232
++ NGYT L AA+Q + LL+ G + ++ G P +A + H E+
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 233 LL 234
LL
Sbjct: 653 LL 654
Score = 76.3 bits (186), Expect = 6e-14
Identities = 52/177 (29%), Positives = 84/177 (47%), Gaps = 4/177 (2%)
Query: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILIT 117
D LL + + D + G+TPL AA N + ++LL+RGA+ +F +
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNT 177
S G+ + V LLL R A + +TP+ AAR+GH ++ +L+ HGA +
Sbjct: 245 IASRRGN----VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 178 QDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+ +NG + + AA+ H + V LL+ A T D P +A HH + +L
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 70.5 bits (171), Expect = 3e-12
Identities = 51/178 (28%), Positives = 83/178 (46%), Gaps = 4/178 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V + + LLD G + + + G +P+ AA + + VR+LL A + +
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTP 341
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+AH ++ K +LL + A PN TP+ A + H +V+ LL+ GA ++
Sbjct: 342 LHVAAHCGHHRVAK---VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
E+G T L A+ GH IV LL+ GA+ + + P +A R H E+ L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 64.7 bits (156), Expect = 2e-10
Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 19/188 (10%)
Query: 111 KQSILITACSAHG-------SEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQ 163
+ + I C+ +G S+E +K V LL + ++ T + AA G +
Sbjct: 33 RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDE 92
Query: 164 VVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAK 223
VV LV +GA VN Q + G+T L AA++ H +V LLE GAN+ + T+DG P +A
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 224 RNKHHEIFNLLSFTLN-PLEGKLQ------QLTKEDTICKILTTDSDREKDHIFSSYTAF 276
+ H N+++ +N +GK++ +DT + +D D + S T F
Sbjct: 153 QQGHE---NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL--SKTGF 207
Query: 277 GDLEVFLH 284
L + H
Sbjct: 208 TPLHIAAH 215
Score = 52.4 bits (124), Expect = 9e-07
Identities = 40/148 (27%), Positives = 62/148 (41%), Gaps = 39/148 (26%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V + L+ G+ VD+ + G+TPL A+ N +LV+
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK-------------------- 718
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
LL AD N + +P+ AA+ GHT +V LL+ +GA N
Sbjct: 719 -----------------FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 177 TQDENGYTALTWAARQGHKNI--VLKLL 202
+G T L A R G+ ++ VLK++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKVV 789
Score = 38.5 bits (88), Expect = 0.013
Identities = 22/72 (30%), Positives = 36/72 (50%)
Query: 151 TPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKML 210
T + AAR G+ + +G ++NT ++NG L A+++GH +V++LL
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 211 QTKDGKMPSEIA 222
TK G IA
Sbjct: 74 TTKKGNTALHIA 85
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 88.2 bits (217), Expect = 1e-17
Identities = 62/173 (35%), Positives = 86/173 (49%), Gaps = 4/173 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G + + LLD G +S G+TPL A + ++ +LL GA+ + +
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
S G L V+ LL R A PNV+ ++ TP+ AAR GHT+V L+ + A+VN
Sbjct: 409 HVASFMGH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHE 229
+ ++ T L AAR GH N+V LLE AN L T G P IA R H E
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Score = 84.0 bits (206), Expect = 3e-16
Identities = 58/176 (32%), Positives = 87/176 (49%), Gaps = 4/176 (2%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITA 118
V +++ LL +G S+D+ + G TPL A+ + + +V+ LL RGA+ + K +
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 119 CSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
+ G E + LL A N + TP+ AAR GHT +V LL+ + A N
Sbjct: 444 AARAGHTE----VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
G+T L AAR+GH VL LLE A++ TK G P +A + + LL
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 83.6 bits (205), Expect = 4e-16
Identities = 67/246 (27%), Positives = 110/246 (44%), Gaps = 29/246 (11%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
G++ + L + + +E +K A+ I G +V+EL++ G +V++ Q G+TPL
Sbjct: 56 GHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115
Query: 84 MYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVE---------- 133
AA + E+V+ LL+ GAN + + + G E + +
Sbjct: 116 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 175
Query: 134 ---------------LLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
+LL + +P+V + TP+ AA + V LL+ GA VN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTL 238
+NG T L A+R+G+ +V LL+ GA +TKD P A RN H I +L
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 239 NPLEGK 244
P++ K
Sbjct: 296 APIQAK 301
Score = 79.3 bits (194), Expect = 7e-15
Identities = 68/249 (27%), Positives = 111/249 (44%), Gaps = 41/249 (16%)
Query: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILIT 117
++ +V+ LL G S S G+TPL AA E+ R LL G +A+ E + +
Sbjct: 581 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640
Query: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG----- 172
+ G E V LLLS+ A+ N+ + +TP+ A++GH V +L+ HG
Sbjct: 641 LAAQEGHAEM----VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 173 ----------------------------AEVNTQDENGYTALTWAARQGHKNIVLKLLEL 204
A+VN + + GY+ L AA+QGH +IV LL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 205 GANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNP----LEGKLQQLTKEDTICKILTT 260
GA+ + DG P IAKR + + ++L + L +++ +T+ +IL
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDV 816
Query: 261 DSDREKDHI 269
D ++ I
Sbjct: 817 SEDEGEELI 825
Score = 79.0 bits (193), Expect = 9e-15
Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 4/182 (2%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A IG ++V+ LL++ + + G TPL AA + E V LL++ A+ + K
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
+ + +G ++ ELLL R+A PN A + +TP+ A + +V LL+ G
Sbjct: 537 FTPLHVAAKYGK----VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFN 232
++ NGYT L AA+Q + LL+ G + ++ G P +A + H E+
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 233 LL 234
LL
Sbjct: 653 LL 654
Score = 76.3 bits (186), Expect = 6e-14
Identities = 52/177 (29%), Positives = 84/177 (47%), Gaps = 4/177 (2%)
Query: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILIT 117
D LL + + D + G+TPL AA N + ++LL+RGA+ +F +
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNT 177
S G+ + V LLL R A + +TP+ AAR+GH ++ +L+ HGA +
Sbjct: 245 IASRRGN----VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 178 QDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+ +NG + + AA+ H + V LL+ A T D P +A HH + +L
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 70.5 bits (171), Expect = 3e-12
Identities = 51/178 (28%), Positives = 83/178 (46%), Gaps = 4/178 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V + + LLD G + + + G +P+ AA + + VR+LL A + +
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTP 341
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+AH ++ K +LL + A PN TP+ A + H +V+ LL+ GA ++
Sbjct: 342 LHVAAHCGHHRVAK---VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
E+G T L A+ GH IV LL+ GA+ + + P +A R H E+ L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 64.7 bits (156), Expect = 2e-10
Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 19/188 (10%)
Query: 111 KQSILITACSAHG-------SEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQ 163
+ + I C+ +G S+E +K V LL + ++ T + AA G +
Sbjct: 33 RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDE 92
Query: 164 VVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAK 223
VV LV +GA VN Q + G+T L AA++ H +V LLE GAN+ + T+DG P +A
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 224 RNKHHEIFNLLSFTLN-PLEGKLQ------QLTKEDTICKILTTDSDREKDHIFSSYTAF 276
+ H N+++ +N +GK++ +DT + +D D + S T F
Sbjct: 153 QQGHE---NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL--SKTGF 207
Query: 277 GDLEVFLH 284
L + H
Sbjct: 208 TPLHIAAH 215
Score = 52.4 bits (124), Expect = 9e-07
Identities = 40/148 (27%), Positives = 62/148 (41%), Gaps = 39/148 (26%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V + L+ G+ VD+ + G+TPL A+ N +LV+
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK-------------------- 718
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
LL AD N + +P+ AA+ GHT +V LL+ +GA N
Sbjct: 719 -----------------FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 177 TQDENGYTALTWAARQGHKNI--VLKLL 202
+G T L A R G+ ++ VLK++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKVV 789
Score = 38.5 bits (88), Expect = 0.013
Identities = 22/72 (30%), Positives = 36/72 (50%)
Query: 151 TPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKML 210
T + AAR G+ + +G ++NT ++NG L A+++GH +V++LL
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 211 QTKDGKMPSEIA 222
TK G IA
Sbjct: 74 TTKKGNTALHIA 85
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 88.2 bits (217), Expect = 1e-17
Identities = 62/173 (35%), Positives = 86/173 (49%), Gaps = 4/173 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G + + LLD G +S G+TPL A + ++ +LL GA+ + +
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
S G L V+ LL R A PNV+ ++ TP+ AAR GHT+V L+ + A+VN
Sbjct: 409 HVASFMGH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHE 229
+ ++ T L AAR GH N+V LLE AN L T G P IA R H E
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Score = 84.0 bits (206), Expect = 3e-16
Identities = 58/176 (32%), Positives = 87/176 (49%), Gaps = 4/176 (2%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITA 118
V +++ LL +G S+D+ + G TPL A+ + + +V+ LL RGA+ + K +
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 119 CSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
+ G E + LL A N + TP+ AAR GHT +V LL+ + A N
Sbjct: 444 AARAGHTE----VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
G+T L AAR+GH VL LLE A++ TK G P +A + + LL
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 83.6 bits (205), Expect = 4e-16
Identities = 67/246 (27%), Positives = 110/246 (44%), Gaps = 29/246 (11%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
G++ + L + + +E +K A+ I G +V+EL++ G +V++ Q G+TPL
Sbjct: 56 GHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115
Query: 84 MYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVE---------- 133
AA + E+V+ LL+ GAN + + + G E + +
Sbjct: 116 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 175
Query: 134 ---------------LLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
+LL + +P+V + TP+ AA + V LL+ GA VN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTL 238
+NG T L A+R+G+ +V LL+ GA +TKD P A RN H I +L
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 239 NPLEGK 244
P++ K
Sbjct: 296 APIQAK 301
Score = 79.3 bits (194), Expect = 7e-15
Identities = 68/249 (27%), Positives = 111/249 (44%), Gaps = 41/249 (16%)
Query: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILIT 117
++ +V+ LL G S S G+TPL AA E+ R LL G +A+ E + +
Sbjct: 581 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640
Query: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG----- 172
+ G E V LLLS+ A+ N+ + +TP+ A++GH V +L+ HG
Sbjct: 641 LAAQEGHAEM----VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 173 ----------------------------AEVNTQDENGYTALTWAARQGHKNIVLKLLEL 204
A+VN + + GY+ L AA+QGH +IV LL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 205 GANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNP----LEGKLQQLTKEDTICKILTT 260
GA+ + DG P IAKR + + ++L + L +++ +T+ +IL
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDV 816
Query: 261 DSDREKDHI 269
D ++ I
Sbjct: 817 SEDEGEELI 825
Score = 79.0 bits (193), Expect = 9e-15
Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 4/182 (2%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A IG ++V+ LL++ + + G TPL AA + E V LL++ A+ + K
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
+ + +G ++ ELLL R+A PN A + +TP+ A + +V LL+ G
Sbjct: 537 FTPLHVAAKYGK----VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFN 232
++ NGYT L AA+Q + LL+ G + ++ G P +A + H E+
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 233 LL 234
LL
Sbjct: 653 LL 654
Score = 76.3 bits (186), Expect = 6e-14
Identities = 52/177 (29%), Positives = 84/177 (47%), Gaps = 4/177 (2%)
Query: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILIT 117
D LL + + D + G+TPL AA N + ++LL+RGA+ +F +
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNT 177
S G+ + V LLL R A + +TP+ AAR+GH ++ +L+ HGA +
Sbjct: 245 IASRRGN----VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 178 QDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+ +NG + + AA+ H + V LL+ A T D P +A HH + +L
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 70.5 bits (171), Expect = 3e-12
Identities = 51/178 (28%), Positives = 83/178 (46%), Gaps = 4/178 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V + + LLD G + + + G +P+ AA + + VR+LL A + +
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTP 341
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+AH ++ K +LL + A PN TP+ A + H +V+ LL+ GA ++
Sbjct: 342 LHVAAHCGHHRVAK---VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
E+G T L A+ GH IV LL+ GA+ + + P +A R H E+ L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 64.7 bits (156), Expect = 2e-10
Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 19/188 (10%)
Query: 111 KQSILITACSAHG-------SEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQ 163
+ + I C+ +G S+E +K V LL + ++ T + AA G +
Sbjct: 33 RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDE 92
Query: 164 VVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAK 223
VV LV +GA VN Q + G+T L AA++ H +V LLE GAN+ + T+DG P +A
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 224 RNKHHEIFNLLSFTLN-PLEGKLQ------QLTKEDTICKILTTDSDREKDHIFSSYTAF 276
+ H N+++ +N +GK++ +DT + +D D + S T F
Sbjct: 153 QQGHE---NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL--SKTGF 207
Query: 277 GDLEVFLH 284
L + H
Sbjct: 208 TPLHIAAH 215
Score = 52.4 bits (124), Expect = 9e-07
Identities = 40/148 (27%), Positives = 62/148 (41%), Gaps = 39/148 (26%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V + L+ G+ VD+ + G+TPL A+ N +LV+
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK-------------------- 718
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
LL AD N + +P+ AA+ GHT +V LL+ +GA N
Sbjct: 719 -----------------FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 177 TQDENGYTALTWAARQGHKNI--VLKLL 202
+G T L A R G+ ++ VLK++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKVV 789
Score = 38.5 bits (88), Expect = 0.013
Identities = 22/72 (30%), Positives = 36/72 (50%)
Query: 151 TPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKML 210
T + AAR G+ + +G ++NT ++NG L A+++GH +V++LL
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 211 QTKDGKMPSEIA 222
TK G IA
Sbjct: 74 TTKKGNTALHIA 85
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 86.7 bits (213), Expect = 4e-17
Identities = 71/245 (28%), Positives = 113/245 (46%), Gaps = 28/245 (11%)
Query: 88 SVANAELVRVLLDRGANASFEKDKQSILITACSAHG-------SEEQILKCVELLLSRNA 140
S ANA +R + + K + I C+ +G S+E ++ V LL R A
Sbjct: 39 SDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREA 98
Query: 141 DPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLK 200
+ + A ++ T + A+ G +VV +LV +GA VN Q +NG+T L AA++ H +V
Sbjct: 99 NVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF 158
Query: 201 LLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQ------QLTKEDTI 254
LL+ GA++ L T+DG P +A + H ++ +LL N +GK++ K+DT
Sbjct: 159 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL--LENDTKGKVRLPALHIAARKDDTK 216
Query: 255 CKILTTDSDREKD----------HIFSSYTAFGDLEVFLHGLGLEHMTDLLKERDITLRH 304
L +D D HI + Y G++ V L D DIT H
Sbjct: 217 AAALLLQNDNNADVESKSGFTPLHIAAHY---GNINVATLLLNRAAAVDFTARNDITPLH 273
Query: 305 LLTMR 309
+ + R
Sbjct: 274 VASKR 278
Score = 85.9 bits (211), Expect = 7e-17
Identities = 55/179 (30%), Positives = 91/179 (50%), Gaps = 4/179 (2%)
Query: 56 IGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSIL 115
+G +VQ+LL G S ++ G+TPL +A + ++ LLD GA+ S K
Sbjct: 509 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568
Query: 116 ITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEV 175
+ + +G L+ LLL ++A P+ A + +TP+ AA + +V LL+ GA
Sbjct: 569 LHVAAKYGK----LEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624
Query: 176 NTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+ +NGYT L AA++ +I LLE GA+ T+ G +A + H ++ +LL
Sbjct: 625 HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683
Score = 82.4 bits (202), Expect = 8e-16
Identities = 63/246 (25%), Positives = 110/246 (44%), Gaps = 29/246 (11%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
G+++ S+ L+R ++ +K A+ I G +V+ L+ +G +V++ Q G+TPL
Sbjct: 85 GHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPL 144
Query: 84 MYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQI--------------- 128
AA + E+V+ LLD GA+ S + + G ++ +
Sbjct: 145 YMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLP 204
Query: 129 ----------LKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
K LLL + + +V + TP+ AA G+ V LL+ A V+
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTL 238
N T L A+++G+ N+V LL+ GA +T+DG P R+ H ++ +L
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
Query: 239 NPLEGK 244
P+ K
Sbjct: 325 APILSK 330
Score = 81.3 bits (199), Expect = 2e-15
Identities = 59/171 (34%), Positives = 88/171 (51%), Gaps = 6/171 (3%)
Query: 65 LLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAH-G 123
LLD G S + + G+TPL AA ++ LL+ GA+A+ +Q I S H
Sbjct: 617 LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN-AVTRQGI----ASVHLA 671
Query: 124 SEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGY 183
++E + V LLL RNA+ N++ + +TP+ AA++ V +LV GA V+ Q + GY
Sbjct: 672 AQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY 731
Query: 184 TALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
T L G+ IV LL+ A +TK+G P A + H I N+L
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVL 782
Score = 79.3 bits (194), Expect = 7e-15
Identities = 60/183 (32%), Positives = 90/183 (49%), Gaps = 6/183 (3%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFE-KDK 111
A +G V++V +L+ G S ++ G T L AA AE+VR L+ GA + KD
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
Query: 112 QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAH 171
Q+ L SA + I V+ LL + A PN A TP+ +AR+GH V A L+ H
Sbjct: 500 QTPL--HISARLGKADI---VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554
Query: 172 GAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIF 231
GA ++ + G+T L AA+ G + LL+ A+ K G P +A + ++
Sbjct: 555 GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVA 614
Query: 232 NLL 234
LL
Sbjct: 615 LLL 617
Score = 76.6 bits (187), Expect = 4e-14
Identities = 66/206 (32%), Positives = 96/206 (46%), Gaps = 10/206 (4%)
Query: 24 GWEIGYLDRTSQKLKRLLPIEEKKEKFKKAM---TIGD-VSLVQELLDSGISVDSNFQYG 79
G G+ L R PI K + + T GD ++ VQ LL + VD
Sbjct: 308 GARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDY 367
Query: 80 WTPLMYAASVANAELVRVLLDRGANASFEK-DKQSILITACSAHGSEEQILKCVELLLSR 138
T L AA + ++ +VLLD+ AN + + + + L AC ++ +K +ELLL
Sbjct: 368 LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIAC-----KKNRIKVMELLLKH 422
Query: 139 NADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIV 198
A +TPI AA GH +V+ L+ HGA NT + G TAL AAR G +V
Sbjct: 423 GASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVV 482
Query: 199 LKLLELGANKMLQTKDGKMPSEIAKR 224
L++ GA + KD + P I+ R
Sbjct: 483 RYLVQDGAQVEAKAKDDQTPLHISAR 508
Score = 73.9 bits (180), Expect = 3e-13
Identities = 58/211 (27%), Positives = 88/211 (41%), Gaps = 37/211 (17%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G+ ++V+ LLD G +D+ + G TPL A + ++V +LLDR A K K +
Sbjct: 279 GNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI-LSKTKNGLSP 337
Query: 117 TACSAHGSEEQILKCVELLLSRN---------------------------------ADPN 143
+ G L CV+LLL N A+PN
Sbjct: 338 LHMATQGDH---LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 394
Query: 144 VACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLE 203
TP+ A + +V+ LL+ HGA + E+G T + AA GH NIV +L+
Sbjct: 395 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH 454
Query: 204 LGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
GA+ G+ +A R+ E+ L
Sbjct: 455 HGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Score = 73.6 bits (179), Expect = 4e-13
Identities = 48/170 (28%), Positives = 79/170 (46%), Gaps = 4/170 (2%)
Query: 65 LLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGS 124
LLD G S+ + G+TPL AA E+ +LL + A+ K + +AH
Sbjct: 551 LLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD-AAGKSGLTPLHVAAHYD 609
Query: 125 EEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYT 184
+++ LLL + A P+ A + TP+ AA+ + L+ +GA+ N G
Sbjct: 610 NQKVAL---LLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIA 666
Query: 185 ALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
++ AA++GH ++V LL AN L K G P +A + + +L
Sbjct: 667 SVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
Score = 68.9 bits (167), Expect = 9e-12
Identities = 57/200 (28%), Positives = 83/200 (41%), Gaps = 5/200 (2%)
Query: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILIT 117
D LL + + D + G+TPL AA N + +LL+R A F +
Sbjct: 214 DTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH 273
Query: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNT 177
S G+ V+LLL R A + R +TP+ AR GH QVV +L+ A + +
Sbjct: 274 VASKRGNANM----VKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329
Query: 178 QDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFN-LLSF 236
+ +NG + L A + H N V LL+ T D +A H+++ LL
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Query: 237 TLNPLEGKLQQLTKEDTICK 256
NP L T CK
Sbjct: 390 KANPNAKALNGFTPLHIACK 409
Score = 66.2 bits (160), Expect = 6e-11
Identities = 50/201 (24%), Positives = 94/201 (46%), Gaps = 25/201 (12%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGAN----------ASFE 108
+ +V+ LLD+G S + G+TPL A + ++V +LL+ A+ +
Sbjct: 153 LEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARK 212
Query: 109 KDKQSILITACSAHGSEEQI---------------LKCVELLLSRNADPNVACRRLMTPI 153
D ++ + + + ++ + + LLL+R A + R +TP+
Sbjct: 213 DDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPL 272
Query: 154 MYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTK 213
A++ G+ +V LL+ GA+++ + +G T L AR GH+ +V LL+ A + +TK
Sbjct: 273 HVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTK 332
Query: 214 DGKMPSEIAKRNKHHEIFNLL 234
+G P +A + H LL
Sbjct: 333 NGLSPLHMATQGDHLNCVQLL 353
Score = 61.6 bits (148), Expect = 1e-09
Identities = 42/142 (29%), Positives = 69/142 (48%), Gaps = 4/142 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V +V LL +V+ + + G TPL AA + VL+++GA+ + +
Sbjct: 675 GHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPL 734
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+G+ +K V LL +A N + TP+ AA+ GHT ++ +L+ + A N
Sbjct: 735 HVGCHYGN----IKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790
Query: 177 TQDENGYTALTWAARQGHKNIV 198
NG TAL A R G+ ++V
Sbjct: 791 ELTVNGNTALGIARRLGYISVV 812
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 85.9 bits (211), Expect = 7e-17
Identities = 57/182 (31%), Positives = 94/182 (51%), Gaps = 6/182 (3%)
Query: 45 EKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGAN 104
EK+ A +GD +++ L+ SG V++ TPL A + + E V+VL+ A+
Sbjct: 15 EKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSAD 74
Query: 105 ASF-EKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQ 163
+ +K+ Q+ L A + + +KC E+++ + NV+ R T + +AA +GH +
Sbjct: 75 VNARDKNWQTPLHVAAA-----NKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVE 129
Query: 164 VVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAK 223
+V LL+A GA +N D+ AL WAA GH ++V L+ GA + K G P A
Sbjct: 130 MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAA 189
Query: 224 RN 225
N
Sbjct: 190 SN 191
Score = 72.0 bits (175), Expect = 1e-12
Identities = 51/179 (28%), Positives = 84/179 (46%), Gaps = 7/179 (3%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDK- 111
A + G +++V+ LL+ G+ +D YG T L A +V L+D GAN + +
Sbjct: 188 AASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNG 247
Query: 112 -QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVA 170
+ A S HG+ C+ELL++ AD N+ + +P+ A G L+
Sbjct: 248 FTPLHFAAASTHGA-----LCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ 302
Query: 171 HGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHE 229
+G E++ D++G T L AAR GH+ ++ L GA+ P +A N H +
Sbjct: 303 NGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD 361
Score = 58.5 bits (140), Expect = 1e-08
Identities = 52/184 (28%), Positives = 82/184 (44%), Gaps = 7/184 (3%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANA-SFEKDK 111
A +G + +V L++ G V + G+TPL AAS +V+ LL+ G
Sbjct: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
Query: 112 QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQV-VALLVA 170
+ L AC + ++ + V L+ A+ N TP+ +AA H + + LLV
Sbjct: 215 NTALHIAC--YNGQDAV---VNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVN 269
Query: 171 HGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEI 230
+GA+VN Q ++G + L A G L++ G KDG P +A R H +
Sbjct: 270 NGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELL 329
Query: 231 FNLL 234
N L
Sbjct: 330 INTL 333
Score = 57.0 bits (136), Expect = 4e-08
Identities = 59/211 (27%), Positives = 93/211 (44%), Gaps = 30/211 (14%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAEL-VRVLLDRGANASFE-KDKQSI 114
G ++V EL+D G +V+ G+TPL +AA+ + L + +L++ GA+ + + KD +S
Sbjct: 225 GQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP 284
Query: 115 L-ITACSAHGSEEQIL-------KCV----------------ELLLSR----NADPNVAC 146
L +TA + Q L CV ELL++ AD
Sbjct: 285 LHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCG 344
Query: 147 RRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
M P+ AA + H+ L++ G E++T D+ G T L AA G+ + L GA
Sbjct: 345 IHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGA 404
Query: 207 NKMLQTKDGKMPSEIAKRNKHHEIFNLLSFT 237
+ + K G+ P A N H L T
Sbjct: 405 DFHKKDKCGRTPLHYAAANCHFHCIETLVTT 435
Score = 57.0 bits (136), Expect = 4e-08
Identities = 53/180 (29%), Positives = 79/180 (43%), Gaps = 13/180 (7%)
Query: 57 GDVSLVQELLDSGISVDS---NFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQS 113
G + + ELL +S + G+TPL +A N + VLL++ F + +
Sbjct: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFT 781
Query: 114 ILITAC-SAHGSEEQILKCVELLLSRNADPNVACR--RLMTPIMYAARDGHTQVVALLVA 170
L A + HG+ C LLL V+CR + TP+ AA H + + LL+
Sbjct: 782 PLHCAIINDHGN------CASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR 835
Query: 171 HGAEVNTQDENGYTALTWAARQGHKNIVLKLLELG-ANKMLQTKDGKMPSEIAKRNKHHE 229
H A VN D +G TAL AA G V L+ A+ ++ KD P +A H +
Sbjct: 836 HSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEK 895
Score = 56.2 bits (134), Expect = 6e-08
Identities = 52/178 (29%), Positives = 78/178 (43%), Gaps = 14/178 (7%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKD----KQ 112
G ++ LL S + +D + G T L AA + E V L++ GA+ F KD +
Sbjct: 553 GHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI-FVKDNVTKRT 611
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADP---NVACRRLMTPIMYAARDGHTQVVALLV 169
+ + + H C+ LLL +P +V + TP+M A GH V+LL+
Sbjct: 612 PLHASVINGH------TLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
Query: 170 AHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKH 227
A V+T D G TAL GH+ V LLE + + + G+ P A H
Sbjct: 666 EKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGH 723
Score = 53.1 bits (126), Expect = 5e-07
Identities = 44/138 (31%), Positives = 61/138 (44%), Gaps = 4/138 (2%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A G L+ L SG + PL AA A+++ R LL G FE D
Sbjct: 321 AARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG----FEIDTP 376
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
C + ++C++LL S AD + + TP+ YAA + H + LV G
Sbjct: 377 DKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG 436
Query: 173 AEVNTQDENGYTALTWAA 190
A VN D+ G TAL +AA
Sbjct: 437 ANVNETDDWGRTALHYAA 454
Score = 53.1 bits (126), Expect = 5e-07
Identities = 51/210 (24%), Positives = 86/210 (40%), Gaps = 59/210 (28%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKD--KQSI 114
G+V ++ L SG + G TPL YAA+ + + L+ GAN + D + ++
Sbjct: 391 GNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTAL 450
Query: 115 LITACS-----------AHGSEEQILK-----------CVELLLSRNADPNVA------- 145
A S AH + E++ + C+E LL +A+P++
Sbjct: 451 HYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNS 510
Query: 146 -----------CRRLM-----------------TPIMYAARDGHTQVVALLVAHGAEVNT 177
C L+ +P+ AA +GH Q + +L+ +++
Sbjct: 511 IHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDI 570
Query: 178 QDENGYTALTWAARQGHKNIVLKLLELGAN 207
+DE G TAL AA +GH V L+ GA+
Sbjct: 571 RDEKGRTALDLAAFKGHTECVEALINPGAS 600
Score = 47.8 bits (112), Expect = 2e-05
Identities = 52/217 (23%), Positives = 97/217 (44%), Gaps = 26/217 (11%)
Query: 27 IGYLDRTSQKLKRLLPIEEKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYA 86
+G S++L+R ++EK+ ++ LL + + + G+ + YA
Sbjct: 465 LGNAHDNSEELERARELKEKEATL----------CLEFLLQNDANPSIRDKEGYNSIHYA 514
Query: 87 ASVANAELVRVLLDRGANASFEKD-----KQSILITACSAHGSEEQILKCVELLLSRNAD 141
A+ + + + +LL+R N+ FE+ K + + A + H + +E+LL D
Sbjct: 515 AAYGHRQCLELLLER-TNSGFEESDSGATKSPLHLAAYNGHH------QALEVLLQSLVD 567
Query: 142 PNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDE-NGYTALTWAARQGHKNIVLK 200
++ + T + AA GHT+ V L+ GA + +D T L + GH +
Sbjct: 568 LDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRL 627
Query: 201 LLELGAN-KMLQTKD--GKMPSEIAKRNKHHEIFNLL 234
LLE+ N + + KD G+ P +A H + +LL
Sbjct: 628 LLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLL 664
Score = 46.6 bits (109), Expect = 5e-05
Identities = 46/169 (27%), Positives = 75/169 (44%), Gaps = 10/169 (5%)
Query: 43 IEEKKEKFKKAMTI--GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLD 100
I+ K K MT G + Q L+ +G +D + G TPL AA + L+ L
Sbjct: 276 IQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRT 335
Query: 101 RGANASF--EKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAAR 158
GA+ + + + A +AH C LLS + + + T + AA
Sbjct: 336 SGADTAKCGIHSMFPLHLAALNAHSD------CCRKLLSSGFEIDTPDKFGRTCLHAAAA 389
Query: 159 DGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGAN 207
G+ + + LL + GA+ + +D+ G T L +AA H + + L+ GAN
Sbjct: 390 GGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGAN 438
Score = 43.9 bits (102), Expect = 3e-04
Identities = 29/103 (28%), Positives = 47/103 (45%)
Query: 132 VELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAAR 191
+ELL+ A N +TP+ A + V +L+ H A+VN +D+N T L AA
Sbjct: 32 IELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAA 91
Query: 192 QGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
++ L ++ + + G+ A N H E+ NLL
Sbjct: 92 NKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/93 (27%), Positives = 43/93 (46%)
Query: 134 LLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQG 193
+L+ + D N TP+ AA G +++ LL+ GA VN +D T L A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 194 HKNIVLKLLELGANKMLQTKDGKMPSEIAKRNK 226
+ V L++ A+ + K+ + P +A NK
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANK 93
Score = 41.2 bits (95), Expect = 0.002
Identities = 36/148 (24%), Positives = 63/148 (42%), Gaps = 37/148 (25%)
Query: 61 LVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACS 120
L+ E+ D+ +VD G TPLM A + + + V +LL++ AN ++ I C+
Sbjct: 627 LLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVD------TVDILGCT 680
Query: 121 AHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDE 180
A R +MT GH + V +L+ + +D
Sbjct: 681 A-----------------------LHRGIMT--------GHEECVQMLLEQEVSILCKDS 709
Query: 181 NGYTALTWAARQGHKNIVLKLLELGANK 208
G T L +AA +GH + +LL++ ++
Sbjct: 710 RGRTPLHYAAARGHATWLSELLQMALSE 737
Score = 34.3 bits (77), Expect = 0.25
Identities = 33/112 (29%), Positives = 50/112 (44%), Gaps = 8/112 (7%)
Query: 60 SLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSILIT 117
SL+ +DS I V G TPL AA + E +++LL A NA K ++++
Sbjct: 796 SLLLGAIDSSI-VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMA 854
Query: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLV 169
A + IL + S AD V + L TP+ A GH + L++
Sbjct: 855 AENGQAGAVDIL-----VNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 85.5 bits (210), Expect = 1e-16
Identities = 59/182 (32%), Positives = 92/182 (50%), Gaps = 6/182 (3%)
Query: 42 PIEEKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDR 101
P++E E F KA G + ++++ L G S D+ Q+ T L A+ + E++ LLD
Sbjct: 146 PVDE--ETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDN 203
Query: 102 GANASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGH 161
GA F+ D+ + G L+ V+LL S AD NV + L TP+ A R G
Sbjct: 204 GATVDFQ-DRLDCTAMHWACRGGH---LEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQ 259
Query: 162 TQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEI 221
++V ++ G E+N +D G TAL A R I+ LL GA+ M + GK P+++
Sbjct: 260 VEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
Query: 222 AK 223
+
Sbjct: 320 VQ 321
Score = 49.3 bits (116), Expect = 8e-06
Identities = 30/102 (29%), Positives = 50/102 (49%)
Query: 129 LKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTW 188
+K +E L+ + + T + A+ +GH +++ L+ +GA V+ QD TA+ W
Sbjct: 161 MKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHW 220
Query: 189 AARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEI 230
A R GH +V L GA+ ++ K P +A R EI
Sbjct: 221 ACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEI 262
Score = 39.7 bits (91), Expect = 0.006
Identities = 27/79 (34%), Positives = 39/79 (49%)
Query: 156 AARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDG 215
AA +G +V+ +A G +T D+ TAL A+ +GH I+ KLL+ GA Q +
Sbjct: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
Query: 216 KMPSEIAKRNKHHEIFNLL 234
A R H E+ LL
Sbjct: 215 CTAMHWACRGGHLEVVKLL 233
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 84.3 bits (207), Expect = 2e-16
Identities = 63/191 (32%), Positives = 95/191 (49%), Gaps = 5/191 (2%)
Query: 68 SGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQ 127
SG+ V+ Q G +PL AA A+L+ +LL GANA Q++ + G Q
Sbjct: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQG-HFQ 791
Query: 128 ILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALT 187
++KC LL NA PN TP++YA GH ++VALL+ HGA +N + G TAL
Sbjct: 792 VVKC---LLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALH 848
Query: 188 WAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRN-KHHEIFNLLSFTLNPLEGKLQ 246
A + H +V LL GA+ + K + + A++N K E+ ++ + L+ +
Sbjct: 849 EAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAE 908
Query: 247 QLTKEDTICKI 257
KE KI
Sbjct: 909 TDRKEYVTVKI 919
Score = 53.5 bits (127), Expect = 4e-07
Identities = 46/158 (29%), Positives = 70/158 (44%), Gaps = 21/158 (13%)
Query: 79 GWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVE----- 133
G TPL AA A L+ +L+ +GA ++ A HG+ L C +
Sbjct: 463 GHTPLHVAAVCGQASLIDLLVSKGA-----------MVNATDYHGATPLHLACQKGYQSV 511
Query: 134 --LLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAE---VNTQDENGYTALTW 188
LLL A V TP+ A GH V LV + E ++ +E G T L
Sbjct: 512 TLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHI 571
Query: 189 AARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNK 226
AAR G++ ++ LL+ GA+ +Q + + P + A +K
Sbjct: 572 AARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSK 609
Score = 53.1 bits (126), Expect = 5e-07
Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 5/111 (4%)
Query: 131 CVELLLSRNADPNVACR-----RLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTA 185
C +L+ R DP+V R TP+ AA G ++ LLV+ GA VN D +G T
Sbjct: 440 CEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATP 499
Query: 186 LTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSF 236
L A ++G++++ L LL A+ +Q +G P +A H + L +
Sbjct: 500 LHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVY 550
Score = 43.1 bits (100), Expect = 5e-04
Identities = 42/134 (31%), Positives = 60/134 (44%), Gaps = 8/134 (5%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G +V+ LLDS + G TPL+YA S + ELV +LL GA+ + +K +
Sbjct: 788 GHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGN--- 844
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGH----TQVVALLVAHG 172
TA E+ + VELLL A V +R T + A ++ QVV VA
Sbjct: 845 TALHEAVIEKHVF-VVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASL 903
Query: 173 AEVNTQDENGYTAL 186
+V D Y +
Sbjct: 904 DDVAETDRKEYVTV 917
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 84.0 bits (206), Expect = 3e-16
Identities = 68/233 (29%), Positives = 106/233 (45%), Gaps = 12/233 (5%)
Query: 14 GGESSESEDDGWEI-------GYLDRTSQKLKRLLPIE----EKKEKFKKAMTIGDVSLV 62
G + ++ DGW G+ + S L + ++ + + + A G +V
Sbjct: 601 GANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV 660
Query: 63 QELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEK-DKQSILITACSA 121
LL G V+ G T L+ AA + + E+V LLD GA + E D ++ L A
Sbjct: 661 LNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC 720
Query: 122 HGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDEN 181
+ + V LL+ R A+ + + MTP++ AA +GH VV LL+ GA+V+ D N
Sbjct: 721 VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN 780
Query: 182 GYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
G T L AA GH ++V LL GA +G+ IA + E+ L
Sbjct: 781 GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
Score = 80.5 bits (197), Expect = 3e-15
Identities = 58/178 (32%), Positives = 83/178 (46%), Gaps = 4/178 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V +V LL+ G VD G TPL+ AAS+ +A +V LL GA + ++
Sbjct: 759 GHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL 818
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+ SA G+ E V LL R D N TP+ AA +GH + L+ GA N
Sbjct: 819 SIASAQGNVE----VVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
D +G A+++GH + V LLE +N + DG+ +A H +I LL
Sbjct: 875 EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELL 932
Score = 78.2 bits (191), Expect = 2e-14
Identities = 64/235 (27%), Positives = 113/235 (48%), Gaps = 21/235 (8%)
Query: 14 GGESSESEDDGW-------EIGYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLV 62
G ++E ++DG + G+ D L+ I+++ + A+ + G +V
Sbjct: 870 GARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 929
Query: 63 QELLDSGISVDSNFQYGWTPLMYAASVANA-ELVRVLLDRGAN--ASFEKDKQSILITAC 119
+ L G V+ G P +Y ++ N + L+ GAN AS + + ++ ++
Sbjct: 930 ELLFSHGADVNCKDADG-RPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCW 988
Query: 120 SAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQD 179
H ++ V++L++ +AD N A + + AA GH +VV LL+ HGA V+
Sbjct: 989 QGH------MEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTC 1042
Query: 180 ENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
G TAL AA++GH ++V LLE GA+ + G+ +A +N H +I LL
Sbjct: 1043 NQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097
Score = 74.7 bits (182), Expect = 2e-13
Identities = 57/175 (32%), Positives = 83/175 (47%), Gaps = 7/175 (4%)
Query: 61 LVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACS 120
++Q L+ +G V+S T + ++ + +R LLD GA+ + L+ +
Sbjct: 496 VLQLLVKAGAHVNSEDDR--TSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAA 553
Query: 121 AHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDE 180
GS L V LL+SR AD + TP+ AAR GHT+VV L+ GA +N D+
Sbjct: 554 YSGS----LDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQ 609
Query: 181 NGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEI-FNLL 234
+G+TAL AA GH +V LL G D + A H +I NLL
Sbjct: 610 DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLL 664
Score = 74.3 bits (181), Expect = 2e-13
Identities = 54/180 (30%), Positives = 87/180 (48%), Gaps = 8/180 (4%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKD--KQSI 114
G S+V L+D G VD + G TPL+ AA + ++V +LL+ GA+ + + +
Sbjct: 726 GHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPL 785
Query: 115 LITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAE 174
L A H S V LL A + T + A+ G+ +VV L+ G +
Sbjct: 786 LAAASMGHAS------VVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLD 839
Query: 175 VNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
N +D+ G+T L AA +GH+ I L+E GA DG++P +A + H++ +L
Sbjct: 840 ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 899
Score = 73.2 bits (178), Expect = 5e-13
Identities = 53/166 (31%), Positives = 77/166 (46%), Gaps = 4/166 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G + +V L+ G ++ +G TPL AA + ++V L+ GAN + D+
Sbjct: 556 GSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN-HTDQDGWTA 614
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+A G ++ V LL + A T + AA GH +V L+ HGAEVN
Sbjct: 615 LRSAAWGGHTEV---VSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIA 222
D G TAL AA GH+ IV LL+ GA + DG+ +A
Sbjct: 672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
Score = 72.4 bits (176), Expect = 8e-13
Identities = 61/188 (32%), Positives = 90/188 (47%), Gaps = 11/188 (5%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAA-----SVANAELVRVLLDRGANASF 107
A +G +V+ LLD G V+ G T L AA S +A +V +L+DRGA
Sbjct: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743
Query: 108 -EKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVA 166
+KD + L+ A + E + V+LLL AD + TP++ AA GH VV
Sbjct: 744 CDKDGMTPLLVA-----AYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVN 798
Query: 167 LLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNK 226
L+ GA V++ D G T L+ A+ QG+ +V LL+ G ++ + G P +A
Sbjct: 799 TLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEG 858
Query: 227 HHEIFNLL 234
H I L
Sbjct: 859 HRLICEAL 866
Score = 72.4 bits (176), Expect = 8e-13
Identities = 54/193 (27%), Positives = 96/193 (49%), Gaps = 21/193 (10%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSILI 116
+++ + L++G +V+++ G T L + + E+V+VL+ A NA+ + + ++
Sbjct: 959 LTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQS 1018
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
A H +K V+LL+ A + C + T + AA++GH VV +L+ HGA+ N
Sbjct: 1019 AAWQGH------VKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPN 1072
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSF 236
D+ G TA+ AA+ GH I+ L + GA+ + +G PS + +
Sbjct: 1073 HADQFGRTAMRVAAKNGHSQIIKLLEKYGASSL----NGCSPSPVHTMEQK--------- 1119
Query: 237 TLNPLEGKLQQLT 249
L L K+Q LT
Sbjct: 1120 PLQSLSSKVQSLT 1132
Score = 71.2 bits (173), Expect = 2e-12
Identities = 55/169 (32%), Positives = 82/169 (48%), Gaps = 4/169 (2%)
Query: 62 VQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSA 121
++ LLD+G SV+ G T L AA + ++V +L+ RGA+ E +T +
Sbjct: 528 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAAR 587
Query: 122 HGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDEN 181
G K V L+ A+ N + T + AA GHT+VV+ L+ G +V+ D +
Sbjct: 588 QGHT----KVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD 643
Query: 182 GYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEI 230
TAL AA GH++IVL LL+ GA +G+ A H EI
Sbjct: 644 SRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREI 692
Score = 69.3 bits (168), Expect = 7e-12
Identities = 51/164 (31%), Positives = 82/164 (50%), Gaps = 4/164 (2%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A ++G S+V LL G +VDS G T L A++ N E+VR LLDRG + + D
Sbjct: 788 AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 847
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
+ + G L C E L+ + A N P + A+++GH V +L+ +
Sbjct: 848 WTPLHMAAFEGHR---LIC-EALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENK 903
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGK 216
+ ++ + +G AL AA +GH++IV L GA+ + DG+
Sbjct: 904 SNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGR 947
Score = 67.8 bits (164), Expect = 2e-11
Identities = 59/185 (31%), Positives = 86/185 (46%), Gaps = 9/185 (4%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G +V LL +G+ VD T L AA + ++V LL GA + ++ +
Sbjct: 622 GHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 681
Query: 117 TACSAHGSEEQILKCVELLLSRNADPN---VACRRLMT--PIMYAARDGHTQVVALLVAH 171
A + G E VE LL A+ N V R ++ + A GH VV+LL+
Sbjct: 682 IAAAYMGHRE----IVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR 737
Query: 172 GAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIF 231
GAEV+ D++G T L AA +GH ++V LLE GA+ +G+ P A H +
Sbjct: 738 GAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVV 797
Query: 232 NLLSF 236
N L F
Sbjct: 798 NTLLF 802
Score = 64.3 bits (155), Expect = 2e-10
Identities = 47/144 (32%), Positives = 71/144 (49%), Gaps = 6/144 (4%)
Query: 93 ELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTP 152
E++++L+ GA+ + E D+ S ++ A E+ I LL A N T
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVR--QALEREDSI----RTLLDNGASVNQCDSNGRTL 548
Query: 153 IMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQT 212
+ AA G VV LLV+ GA++ +D +G+T LT AARQGH +V L+ GAN
Sbjct: 549 LANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTD 608
Query: 213 KDGKMPSEIAKRNKHHEIFNLLSF 236
+DG A H E+ + L +
Sbjct: 609 QDGWTALRSAAWGGHTEVVSALLY 632
Score = 29.6 bits (65), Expect = 6.3
Identities = 14/49 (28%), Positives = 29/49 (59%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANA 105
G + +VQ LL+ G + Q+G T + AA +++++++L GA++
Sbjct: 1056 GHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASS 1104
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 83.2 bits (204), Expect = 5e-16
Identities = 49/145 (33%), Positives = 81/145 (55%), Gaps = 4/145 (2%)
Query: 78 YGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVELLLS 137
+G T L AA E+ R+LL++GA + + ++ + + G + V+LLL+
Sbjct: 1033 WGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQ----IVDLLLT 1088
Query: 138 RNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNI 197
AD N+A ++ TP+M AA +GH V L+A GA + D+ G TAL+WA +GH ++
Sbjct: 1089 HGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSV 1148
Query: 198 VLKLLELGANKMLQTKDGKMPSEIA 222
V L++ GA K+G+ P ++A
Sbjct: 1149 VRSLVDNGAATDHADKNGRTPLDLA 1173
Score = 57.0 bits (136), Expect = 4e-08
Identities = 52/192 (27%), Positives = 89/192 (46%), Gaps = 13/192 (6%)
Query: 56 IGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANAS-FEKDKQSI 114
+G +V LL+ G +VD++ + G TPL YAA+ +V +L + A +K+ Q
Sbjct: 895 LGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCA 954
Query: 115 LITACSAHGSE--EQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLV--- 169
L+ A E + +++C + + + ++ AA G+T++V+ L+
Sbjct: 955 LVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLP 1014
Query: 170 ------AHGAEVNTQDEN-GYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIA 222
A++N+ D G TALT AA +G + LLE GA + G +P
Sbjct: 1015 EKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFST 1074
Query: 223 KRNKHHEIFNLL 234
R H +I +LL
Sbjct: 1075 VRQGHWQIVDLL 1086
Score = 57.0 bits (136), Expect = 4e-08
Identities = 45/153 (29%), Positives = 74/153 (48%), Gaps = 10/153 (6%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQS--- 113
G + + + LL+ G +V + G PL + ++V +LL GA+ + DKQ
Sbjct: 1045 GKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMA-DKQGRTP 1103
Query: 114 ILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGA 173
+++ A H L V+ LL++ A + + +T + +A GH VV LV +GA
Sbjct: 1104 LMMAASEGH------LGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGA 1157
Query: 174 EVNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
+ D+NG T L AA G +V L++ GA
Sbjct: 1158 ATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGA 1190
Score = 56.6 bits (135), Expect = 5e-08
Identities = 51/152 (33%), Positives = 72/152 (47%), Gaps = 8/152 (5%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGAN-ASFEKDKQSIL 115
G +V LL G V+ + G TPLM AAS + V LL +GA+ A +K+ + L
Sbjct: 1078 GHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTAL 1137
Query: 116 ITAC-SAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAE 174
AC H L V L+ A + A + TP+ AA G +VV LV HGA
Sbjct: 1138 SWACLKGH------LSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAM 1191
Query: 175 VNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
+ D +G L A + ++V+ LL+ GA
Sbjct: 1192 IEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
Score = 50.8 bits (120), Expect = 3e-06
Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 2/113 (1%)
Query: 91 NAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLM 150
N ++ R+L+ GAN ++ + + C S + V LLL A+ + + +
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQ--SHLGYTEMVALLLEFGANVDASSESGL 919
Query: 151 TPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLE 203
TP+ YAA G+ +V LL A+V+ D+NG AL AA +GH +V L++
Sbjct: 920 TPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQ 972
Score = 29.3 bits (64), Expect = 8.2
Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 10/74 (13%)
Query: 147 RRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDE--NGYTALTWAARQGHKNIVLKLLEL 204
R L TP + +R LL+ GA +N + E N L + G+ +V LLE
Sbjct: 856 RNLYTPNIKVSR--------LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEF 907
Query: 205 GANKMLQTKDGKMP 218
GAN ++ G P
Sbjct: 908 GANVDASSESGLTP 921
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 82.8 bits (203), Expect = 6e-16
Identities = 65/241 (26%), Positives = 112/241 (46%), Gaps = 16/241 (6%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITA 118
+ + LL+ G + + G TPL A+ + ++V +LLD+GAN +T+
Sbjct: 621 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG---LTS 677
Query: 119 CSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
E+++ ++L AD + + TP++ A G+ ++V L+ GA VN +
Sbjct: 678 LHLAAQEDKV-NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK 736
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTL 238
+NGYT L AA+QGH +I+ LL+ GA T +G IAKR + + + L
Sbjct: 737 TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVT 796
Query: 239 NPLEGKLQQLTKE------DTICKILTTDSDREKDHIFSSYTAFGDLEVFLHGLGLEHMT 292
+ +T++ +T+ ++L SD E D T GD +L L+ +
Sbjct: 797 EEVTTTTTTITEKHKLNVPETMTEVLDV-SDEEGDD-----TMTGDGGEYLRPEDLKELG 850
Query: 293 D 293
D
Sbjct: 851 D 851
Score = 80.5 bits (197), Expect = 3e-15
Identities = 58/190 (30%), Positives = 88/190 (46%), Gaps = 4/190 (2%)
Query: 45 EKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGAN 104
E++ A +G +VQ LL D+ G+TPL +A ++ VLL+ GA
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534
Query: 105 ASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQV 164
S K + + +GS L +LLL R A + A + +TP+ AA + +V
Sbjct: 535 HSLATKKGFTPLHVAAKYGS----LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 590
Query: 165 VALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKR 224
LL+ GA + +NGYT L AA++ I LL GA + TK G P +A +
Sbjct: 591 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 650
Query: 225 NKHHEIFNLL 234
H ++ LL
Sbjct: 651 EGHTDMVTLL 660
Score = 80.5 bits (197), Expect = 3e-15
Identities = 51/179 (28%), Positives = 90/179 (50%), Gaps = 4/179 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V + LL++G + + G+TPL AA + ++ ++LL R A A K +
Sbjct: 520 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD-SAGKNGLTP 578
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+AH +++ LLL + A P+ + TP+ AA+ Q+ + L+ +GAE N
Sbjct: 579 LHVAAHYDNQKVAL---LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 635
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLS 235
+ G T L A+++GH ++V LL+ GAN + TK G +A + + ++L+
Sbjct: 636 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILT 694
Score = 77.0 bits (188), Expect = 3e-14
Identities = 52/176 (29%), Positives = 87/176 (49%), Gaps = 4/176 (2%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITA 118
+ +++ L+ G S+ + + G TP+ AA + + +V +LL GA+ + +
Sbjct: 390 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 449
Query: 119 CSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
+ G E +++C LL A + R TP+ A+R G T++V LL+ H A +
Sbjct: 450 AARAGQVE-VVRC---LLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAA 505
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
NGYT L +AR+G ++ LLE GA L TK G P +A + ++ LL
Sbjct: 506 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 561
Score = 76.6 bits (187), Expect = 4e-14
Identities = 58/197 (29%), Positives = 94/197 (47%), Gaps = 15/197 (7%)
Query: 84 MYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHG-------SEEQILKCVELLL 136
M S +NA +R + E K I I C+ +G ++E + V+ LL
Sbjct: 4 MLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL 63
Query: 137 SRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKN 196
R + + A ++ T + A+ G +VV +LV GA +N Q +NG+T L AA++ H +
Sbjct: 64 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHID 123
Query: 197 IVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQ------QLTK 250
+V LLE GAN+ T+DG P +A + H++ +L N +GK++ K
Sbjct: 124 VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL--LENDTKGKVRLPALHIAARK 181
Query: 251 EDTICKILTTDSDREKD 267
+DT L +D D
Sbjct: 182 DDTKSAALLLQNDHNAD 198
Score = 76.6 bits (187), Expect = 4e-14
Identities = 64/244 (26%), Positives = 107/244 (43%), Gaps = 37/244 (15%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
G++ + L R ++ +K A+ I G +V+ L+ G ++++ Q G+TPL
Sbjct: 54 GHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113
Query: 84 MYAASVANAELVRVLLDRGANASF--EKDKQSILITACSAHGSEEQIL------------ 129
AA + ++V+ LL+ GAN S E + + H IL
Sbjct: 114 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLP 173
Query: 130 -----------KCVELLLSRNADPNVACRRLM--------TPIMYAARDGHTQVVALLVA 170
K LLL + + +V + ++ TP+ AA G+ V LL+
Sbjct: 174 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 233
Query: 171 HGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEI 230
GA V+ NG T L A+++G+ N+V LL+ G +T+DG P A R+ H ++
Sbjct: 234 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 293
Query: 231 FNLL 234
LL
Sbjct: 294 VELL 297
Score = 73.9 bits (180), Expect = 3e-13
Identities = 58/208 (27%), Positives = 92/208 (44%), Gaps = 31/208 (14%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G+ ++V+ LLD G +D+ + G TPL AA + ++V +LL+RGA + K +
Sbjct: 256 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKNGLSP 314
Query: 117 TACSAHGSEEQILK------------------------------CVELLLSRNADPNVAC 146
+A G + +K +LLL + A+PN
Sbjct: 315 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 374
Query: 147 RRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
TP+ A + +V+ LLV +GA + E+G T + AA GH NIVL LL+ GA
Sbjct: 375 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 434
Query: 207 NKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+ + G+ +A R E+ L
Sbjct: 435 SPDVTNIRGETALHMAARAGQVEVVRCL 462
Score = 73.6 bits (179), Expect = 4e-13
Identities = 54/204 (26%), Positives = 94/204 (46%), Gaps = 33/204 (16%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGAN----------ASFE 108
+ +V+ LL++G + + + G+TPL A + + V +LL+ A+ +
Sbjct: 122 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 181
Query: 109 KDKQSILITACSAHGSEEQILKCVE-----------------------LLLSRNADPNVA 145
D +S + + H ++ Q V LLL+R A +
Sbjct: 182 DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 241
Query: 146 CRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELG 205
R +TP+ A++ G+T +V LL+ G +++ + +G T L AAR GH +V LLE G
Sbjct: 242 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 301
Query: 206 ANKMLQTKDGKMPSEIAKRNKHHE 229
A + +TK+G P +A + H E
Sbjct: 302 APLLARTKNGLSPLHMAAQGDHVE 325
Score = 71.6 bits (174), Expect = 1e-12
Identities = 59/192 (30%), Positives = 83/192 (43%), Gaps = 5/192 (2%)
Query: 66 LDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSE 125
+ S + V+ + G+TPL AA N + +LL+RGA F + S G+
Sbjct: 199 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 258
Query: 126 EQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTA 185
V+LLL R + R +TP+ AAR GH QVV LL+ GA + + +NG +
Sbjct: 259 NM----VKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 314
Query: 186 LTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFN-LLSFTLNPLEGK 244
L AA+ H V LL+ A T D +A H+ + LL NP
Sbjct: 315 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 374
Query: 245 LQQLTKEDTICK 256
L T CK
Sbjct: 375 LNGFTPLHIACK 386
Score = 68.9 bits (167), Expect = 9e-12
Identities = 47/143 (32%), Positives = 73/143 (51%), Gaps = 6/143 (4%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANA-SFEKDKQSIL 115
G +V LLD G ++ + + G T L AA + +L GA+ + K + L
Sbjct: 652 GHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPL 711
Query: 116 ITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEV 175
I AC +G+ +K V LL + A+ N + TP+ AA+ GHT ++ +L+ HGA+
Sbjct: 712 IVACH-YGN----VKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 766
Query: 176 NTQDENGYTALTWAARQGHKNIV 198
N NG TAL A R G+ ++V
Sbjct: 767 NATTANGNTALAIAKRLGYISVV 789
Score = 68.2 bits (165), Expect = 2e-11
Identities = 54/182 (29%), Positives = 83/182 (45%), Gaps = 4/182 (2%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A +G +++V LL +G S D G T L AA E+VR LL GA ++
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
+ S G E V+LLL A P+ A TP+ +AR+G V ++L+ G
Sbjct: 477 QTPLHIASRLGKTE----IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 532
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFN 232
A + + G+T L AA+ G ++ LL+ A K+G P +A + ++
Sbjct: 533 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 592
Query: 233 LL 234
LL
Sbjct: 593 LL 594
Score = 38.1 bits (87), Expect = 0.018
Identities = 25/78 (32%), Positives = 39/78 (50%), Gaps = 2/78 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSI 114
G+V +V LL G +V++ + G+TPL AA + ++ VLL GA NA+ ++
Sbjct: 718 GNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 777
Query: 115 LITACSAHGSEEQILKCV 132
I + S LK V
Sbjct: 778 AIAKRLGYISVVDTLKVV 795
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 82.8 bits (203), Expect = 6e-16
Identities = 65/241 (26%), Positives = 112/241 (46%), Gaps = 16/241 (6%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITA 118
+ + LL+ G + + G TPL A+ + ++V +LLD+GAN +T+
Sbjct: 642 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG---LTS 698
Query: 119 CSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
E+++ ++L AD + + TP++ A G+ ++V L+ GA VN +
Sbjct: 699 LHLAAQEDKV-NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK 757
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTL 238
+NGYT L AA+QGH +I+ LL+ GA T +G IAKR + + + L
Sbjct: 758 TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVT 817
Query: 239 NPLEGKLQQLTKE------DTICKILTTDSDREKDHIFSSYTAFGDLEVFLHGLGLEHMT 292
+ +T++ +T+ ++L SD E D T GD +L L+ +
Sbjct: 818 EEVTTTTTTITEKHKLNVPETMTEVLDV-SDEEGDD-----TMTGDGGEYLRPEDLKELG 871
Query: 293 D 293
D
Sbjct: 872 D 872
Score = 80.5 bits (197), Expect = 3e-15
Identities = 58/190 (30%), Positives = 88/190 (46%), Gaps = 4/190 (2%)
Query: 45 EKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGAN 104
E++ A +G +VQ LL D+ G+TPL +A ++ VLL+ GA
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 105 ASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQV 164
S K + + +GS L +LLL R A + A + +TP+ AA + +V
Sbjct: 556 HSLATKKGFTPLHVAAKYGS----LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 611
Query: 165 VALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKR 224
LL+ GA + +NGYT L AA++ I LL GA + TK G P +A +
Sbjct: 612 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671
Query: 225 NKHHEIFNLL 234
H ++ LL
Sbjct: 672 EGHTDMVTLL 681
Score = 80.5 bits (197), Expect = 3e-15
Identities = 51/179 (28%), Positives = 90/179 (50%), Gaps = 4/179 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V + LL++G + + G+TPL AA + ++ ++LL R A A K +
Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD-SAGKNGLTP 599
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+AH +++ LLL + A P+ + TP+ AA+ Q+ + L+ +GAE N
Sbjct: 600 LHVAAHYDNQKVAL---LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLS 235
+ G T L A+++GH ++V LL+ GAN + TK G +A + + ++L+
Sbjct: 657 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILT 715
Score = 77.0 bits (188), Expect = 3e-14
Identities = 52/176 (29%), Positives = 87/176 (49%), Gaps = 4/176 (2%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITA 118
+ +++ L+ G S+ + + G TP+ AA + + +V +LL GA+ + +
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470
Query: 119 CSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
+ G E +++C LL A + R TP+ A+R G T++V LL+ H A +
Sbjct: 471 AARAGQVE-VVRC---LLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAA 526
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
NGYT L +AR+G ++ LLE GA L TK G P +A + ++ LL
Sbjct: 527 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Score = 76.6 bits (187), Expect = 4e-14
Identities = 64/244 (26%), Positives = 107/244 (43%), Gaps = 37/244 (15%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
G++ + L R ++ +K A+ I G +V+ L+ G ++++ Q G+TPL
Sbjct: 75 GHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 134
Query: 84 MYAASVANAELVRVLLDRGANASF--EKDKQSILITACSAHGSEEQIL------------ 129
AA + ++V+ LL+ GAN S E + + H IL
Sbjct: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLP 194
Query: 130 -----------KCVELLLSRNADPNVACRRLM--------TPIMYAARDGHTQVVALLVA 170
K LLL + + +V + ++ TP+ AA G+ V LL+
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 171 HGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEI 230
GA V+ NG T L A+++G+ N+V LL+ G +T+DG P A R+ H ++
Sbjct: 255 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 314
Query: 231 FNLL 234
LL
Sbjct: 315 VELL 318
Score = 75.9 bits (185), Expect = 8e-14
Identities = 57/193 (29%), Positives = 93/193 (48%), Gaps = 15/193 (7%)
Query: 88 SVANAELVRVLLDRGANASFEKDKQSILITACSAHG-------SEEQILKCVELLLSRNA 140
S +NA +R + E K I I C+ +G ++E + V+ LL R +
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 141 DPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLK 200
+ A ++ T + A+ G +VV +LV GA +N Q +NG+T L AA++ H ++V
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
Query: 201 LLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQ------QLTKEDTI 254
LLE GAN+ T+DG P +A + H++ +L N +GK++ K+DT
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAIL--LENDTKGKVRLPALHIAARKDDTK 206
Query: 255 CKILTTDSDREKD 267
L +D D
Sbjct: 207 SAALLLQNDHNAD 219
Score = 73.9 bits (180), Expect = 3e-13
Identities = 58/208 (27%), Positives = 92/208 (44%), Gaps = 31/208 (14%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G+ ++V+ LLD G +D+ + G TPL AA + ++V +LL+RGA + K +
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKNGLSP 335
Query: 117 TACSAHGSEEQILK------------------------------CVELLLSRNADPNVAC 146
+A G + +K +LLL + A+PN
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Query: 147 RRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
TP+ A + +V+ LLV +GA + E+G T + AA GH NIVL LL+ GA
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 207 NKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+ + G+ +A R E+ L
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCL 483
Score = 73.6 bits (179), Expect = 4e-13
Identities = 54/204 (26%), Positives = 94/204 (46%), Gaps = 33/204 (16%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGAN----------ASFE 108
+ +V+ LL++G + + + G+TPL A + + V +LL+ A+ +
Sbjct: 143 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 202
Query: 109 KDKQSILITACSAHGSEEQILKCVE-----------------------LLLSRNADPNVA 145
D +S + + H ++ Q V LLL+R A +
Sbjct: 203 DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262
Query: 146 CRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELG 205
R +TP+ A++ G+T +V LL+ G +++ + +G T L AAR GH +V LLE G
Sbjct: 263 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 322
Query: 206 ANKMLQTKDGKMPSEIAKRNKHHE 229
A + +TK+G P +A + H E
Sbjct: 323 APLLARTKNGLSPLHMAAQGDHVE 346
Score = 71.6 bits (174), Expect = 1e-12
Identities = 59/192 (30%), Positives = 83/192 (43%), Gaps = 5/192 (2%)
Query: 66 LDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSE 125
+ S + V+ + G+TPL AA N + +LL+RGA F + S G+
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 279
Query: 126 EQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTA 185
V+LLL R + R +TP+ AAR GH QVV LL+ GA + + +NG +
Sbjct: 280 NM----VKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 335
Query: 186 LTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFN-LLSFTLNPLEGK 244
L AA+ H V LL+ A T D +A H+ + LL NP
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Query: 245 LQQLTKEDTICK 256
L T CK
Sbjct: 396 LNGFTPLHIACK 407
Score = 68.9 bits (167), Expect = 9e-12
Identities = 47/143 (32%), Positives = 73/143 (51%), Gaps = 6/143 (4%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANA-SFEKDKQSIL 115
G +V LLD G ++ + + G T L AA + +L GA+ + K + L
Sbjct: 673 GHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPL 732
Query: 116 ITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEV 175
I AC +G+ +K V LL + A+ N + TP+ AA+ GHT ++ +L+ HGA+
Sbjct: 733 IVACH-YGN----VKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787
Query: 176 NTQDENGYTALTWAARQGHKNIV 198
N NG TAL A R G+ ++V
Sbjct: 788 NATTANGNTALAIAKRLGYISVV 810
Score = 68.2 bits (165), Expect = 2e-11
Identities = 54/182 (29%), Positives = 83/182 (45%), Gaps = 4/182 (2%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A +G +++V LL +G S D G T L AA E+VR LL GA ++
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
+ S G E V+LLL A P+ A TP+ +AR+G V ++L+ G
Sbjct: 498 QTPLHIASRLGKTE----IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFN 232
A + + G+T L AA+ G ++ LL+ A K+G P +A + ++
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 613
Query: 233 LL 234
LL
Sbjct: 614 LL 615
Score = 38.1 bits (87), Expect = 0.018
Identities = 25/78 (32%), Positives = 39/78 (50%), Gaps = 2/78 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSI 114
G+V +V LL G +V++ + G+TPL AA + ++ VLL GA NA+ ++
Sbjct: 739 GNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Query: 115 LITACSAHGSEEQILKCV 132
I + S LK V
Sbjct: 799 AIAKRLGYISVVDTLKVV 816
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 82.8 bits (203), Expect = 6e-16
Identities = 65/241 (26%), Positives = 112/241 (46%), Gaps = 16/241 (6%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITA 118
+ + LL+ G + + G TPL A+ + ++V +LLD+GAN +T+
Sbjct: 642 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG---LTS 698
Query: 119 CSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
E+++ ++L AD + + TP++ A G+ ++V L+ GA VN +
Sbjct: 699 LHLAAQEDKV-NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK 757
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTL 238
+NGYT L AA+QGH +I+ LL+ GA T +G IAKR + + + L
Sbjct: 758 TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVT 817
Query: 239 NPLEGKLQQLTKE------DTICKILTTDSDREKDHIFSSYTAFGDLEVFLHGLGLEHMT 292
+ +T++ +T+ ++L SD E D T GD +L L+ +
Sbjct: 818 EEVTTTTTTITEKHKLNVPETMTEVLDV-SDEEGDD-----TMTGDGGEYLRPEDLKELG 871
Query: 293 D 293
D
Sbjct: 872 D 872
Score = 80.5 bits (197), Expect = 3e-15
Identities = 58/190 (30%), Positives = 88/190 (46%), Gaps = 4/190 (2%)
Query: 45 EKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGAN 104
E++ A +G +VQ LL D+ G+TPL +A ++ VLL+ GA
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 105 ASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQV 164
S K + + +GS L +LLL R A + A + +TP+ AA + +V
Sbjct: 556 HSLATKKGFTPLHVAAKYGS----LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 611
Query: 165 VALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKR 224
LL+ GA + +NGYT L AA++ I LL GA + TK G P +A +
Sbjct: 612 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671
Query: 225 NKHHEIFNLL 234
H ++ LL
Sbjct: 672 EGHTDMVTLL 681
Score = 80.5 bits (197), Expect = 3e-15
Identities = 51/179 (28%), Positives = 90/179 (50%), Gaps = 4/179 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V + LL++G + + G+TPL AA + ++ ++LL R A A K +
Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD-SAGKNGLTP 599
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+AH +++ LLL + A P+ + TP+ AA+ Q+ + L+ +GAE N
Sbjct: 600 LHVAAHYDNQKVAL---LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLS 235
+ G T L A+++GH ++V LL+ GAN + TK G +A + + ++L+
Sbjct: 657 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILT 715
Score = 77.0 bits (188), Expect = 3e-14
Identities = 52/176 (29%), Positives = 87/176 (49%), Gaps = 4/176 (2%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITA 118
+ +++ L+ G S+ + + G TP+ AA + + +V +LL GA+ + +
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470
Query: 119 CSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQ 178
+ G E +++C LL A + R TP+ A+R G T++V LL+ H A +
Sbjct: 471 AARAGQVE-VVRC---LLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAA 526
Query: 179 DENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
NGYT L +AR+G ++ LLE GA L TK G P +A + ++ LL
Sbjct: 527 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Score = 76.6 bits (187), Expect = 4e-14
Identities = 64/244 (26%), Positives = 107/244 (43%), Gaps = 37/244 (15%)
Query: 28 GYLDRTSQKLKRLLPIEEKKEKFKKAMTI----GDVSLVQELLDSGISVDSNFQYGWTPL 83
G++ + L R ++ +K A+ I G +V+ L+ G ++++ Q G+TPL
Sbjct: 75 GHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 134
Query: 84 MYAASVANAELVRVLLDRGANASF--EKDKQSILITACSAHGSEEQIL------------ 129
AA + ++V+ LL+ GAN S E + + H IL
Sbjct: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLP 194
Query: 130 -----------KCVELLLSRNADPNVACRRLM--------TPIMYAARDGHTQVVALLVA 170
K LLL + + +V + ++ TP+ AA G+ V LL+
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 171 HGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEI 230
GA V+ NG T L A+++G+ N+V LL+ G +T+DG P A R+ H ++
Sbjct: 255 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 314
Query: 231 FNLL 234
LL
Sbjct: 315 VELL 318
Score = 75.9 bits (185), Expect = 8e-14
Identities = 57/193 (29%), Positives = 93/193 (48%), Gaps = 15/193 (7%)
Query: 88 SVANAELVRVLLDRGANASFEKDKQSILITACSAHG-------SEEQILKCVELLLSRNA 140
S +NA +R + E K I I C+ +G ++E + V+ LL R +
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 141 DPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLK 200
+ A ++ T + A+ G +VV +LV GA +N Q +NG+T L AA++ H ++V
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
Query: 201 LLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQ------QLTKEDTI 254
LLE GAN+ T+DG P +A + H++ +L N +GK++ K+DT
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAIL--LENDTKGKVRLPALHIAARKDDTK 206
Query: 255 CKILTTDSDREKD 267
L +D D
Sbjct: 207 SAALLLQNDHNAD 219
Score = 73.9 bits (180), Expect = 3e-13
Identities = 58/208 (27%), Positives = 92/208 (44%), Gaps = 31/208 (14%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G+ ++V+ LLD G +D+ + G TPL AA + ++V +LL+RGA + K +
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKNGLSP 335
Query: 117 TACSAHGSEEQILK------------------------------CVELLLSRNADPNVAC 146
+A G + +K +LLL + A+PN
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Query: 147 RRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
TP+ A + +V+ LLV +GA + E+G T + AA GH NIVL LL+ GA
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 207 NKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+ + G+ +A R E+ L
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCL 483
Score = 73.6 bits (179), Expect = 4e-13
Identities = 54/204 (26%), Positives = 94/204 (46%), Gaps = 33/204 (16%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGAN----------ASFE 108
+ +V+ LL++G + + + G+TPL A + + V +LL+ A+ +
Sbjct: 143 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 202
Query: 109 KDKQSILITACSAHGSEEQILKCVE-----------------------LLLSRNADPNVA 145
D +S + + H ++ Q V LLL+R A +
Sbjct: 203 DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262
Query: 146 CRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELG 205
R +TP+ A++ G+T +V LL+ G +++ + +G T L AAR GH +V LLE G
Sbjct: 263 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 322
Query: 206 ANKMLQTKDGKMPSEIAKRNKHHE 229
A + +TK+G P +A + H E
Sbjct: 323 APLLARTKNGLSPLHMAAQGDHVE 346
Score = 71.6 bits (174), Expect = 1e-12
Identities = 59/192 (30%), Positives = 83/192 (43%), Gaps = 5/192 (2%)
Query: 66 LDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSE 125
+ S + V+ + G+TPL AA N + +LL+RGA F + S G+
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 279
Query: 126 EQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTA 185
V+LLL R + R +TP+ AAR GH QVV LL+ GA + + +NG +
Sbjct: 280 NM----VKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 335
Query: 186 LTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFN-LLSFTLNPLEGK 244
L AA+ H V LL+ A T D +A H+ + LL NP
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Query: 245 LQQLTKEDTICK 256
L T CK
Sbjct: 396 LNGFTPLHIACK 407
Score = 68.9 bits (167), Expect = 9e-12
Identities = 47/143 (32%), Positives = 73/143 (51%), Gaps = 6/143 (4%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANA-SFEKDKQSIL 115
G +V LLD G ++ + + G T L AA + +L GA+ + K + L
Sbjct: 673 GHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPL 732
Query: 116 ITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEV 175
I AC +G+ +K V LL + A+ N + TP+ AA+ GHT ++ +L+ HGA+
Sbjct: 733 IVACH-YGN----VKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787
Query: 176 NTQDENGYTALTWAARQGHKNIV 198
N NG TAL A R G+ ++V
Sbjct: 788 NATTANGNTALAIAKRLGYISVV 810
Score = 68.2 bits (165), Expect = 2e-11
Identities = 54/182 (29%), Positives = 83/182 (45%), Gaps = 4/182 (2%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A +G +++V LL +G S D G T L AA E+VR LL GA ++
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
+ S G E V+LLL A P+ A TP+ +AR+G V ++L+ G
Sbjct: 498 QTPLHIASRLGKTE----IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFN 232
A + + G+T L AA+ G ++ LL+ A K+G P +A + ++
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 613
Query: 233 LL 234
LL
Sbjct: 614 LL 615
Score = 38.1 bits (87), Expect = 0.018
Identities = 25/78 (32%), Positives = 39/78 (50%), Gaps = 2/78 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSI 114
G+V +V LL G +V++ + G+TPL AA + ++ VLL GA NA+ ++
Sbjct: 739 GNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Query: 115 LITACSAHGSEEQILKCV 132
I + S LK V
Sbjct: 799 AIAKRLGYISVVDTLKVV 816
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 81.6 bits (200), Expect = 1e-15
Identities = 58/175 (33%), Positives = 96/175 (54%), Gaps = 9/175 (5%)
Query: 53 AMTIGDVSLVQELL----DSGISVD-SNFQYGWTPLMYAASVANAELVRVLLDRGANASF 107
A ++G S+VQ LL + + V+ ++ +G T L AA E+ +LL GA S
Sbjct: 1040 AASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVS- 1098
Query: 108 EKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVAL 167
+++ + C+A QI V LLL R D N++ ++ TP+M AA +GH V
Sbjct: 1099 RTNRRGVPPLFCAARQGHWQI---VRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEF 1155
Query: 168 LVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIA 222
L++ GA +++ D+ G +AL+WA +GH+ +V L+E GA K+G+ P ++A
Sbjct: 1156 LLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLA 1210
Score = 75.1 bits (183), Expect = 1e-13
Identities = 51/152 (33%), Positives = 78/152 (51%), Gaps = 8/152 (5%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSI 114
G + + + LL G +V + G PL AA + ++VR+LL+RG N S ++ + +
Sbjct: 1082 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1141
Query: 115 LITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAE 174
++ AC H L VE LLS+ A + + ++ + +A GH VV LV GA
Sbjct: 1142 MVAACEGH------LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAA 1195
Query: 175 VNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
++ D+NG T L AA G VL L+E GA
Sbjct: 1196 IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGA 1227
Score = 60.8 bits (146), Expect = 3e-09
Identities = 58/213 (27%), Positives = 85/213 (39%), Gaps = 41/213 (19%)
Query: 56 IGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASF--EKDKQS 113
+G +V LL+ G +D + G T L YAA+ + +LV +L +G +K + +
Sbjct: 937 LGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCA 996
Query: 114 ILITACSAHGSEEQ-ILKC---------------------------------VELLLSRN 139
++ +A HG Q +L C V+ LL
Sbjct: 997 LVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGME 1056
Query: 140 ADPNVACRRL-----MTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGH 194
+ V T + AA G +V LL+ HGA V+ + G L AARQGH
Sbjct: 1057 KEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGH 1116
Query: 195 KNIVLKLLELGANKMLQTKDGKMPSEIAKRNKH 227
IV LLE G + L K G+ P +A H
Sbjct: 1117 WQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1149
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 91 NAELVRVLLDRGANASFEKDKQSILITAC-SAHGSEEQILKCVELLLSRNADPNVACRRL 149
N ++ R+L+ GAN ++ + + C +H E++ V LLL A +
Sbjct: 904 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEV---VTLLLEFGACLDGTSENG 960
Query: 150 MTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLL 202
MT + YAA GH ++V LL G V+ D+ G AL +A +GH +I+ LL
Sbjct: 961 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1013
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/75 (34%), Positives = 36/75 (48%)
Query: 160 GHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPS 219
GH +VV LL+ GA ++ ENG TAL +AA GH +V L + G K G+
Sbjct: 938 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
Query: 220 EIAKRNKHHEIFNLL 234
+ H +I L
Sbjct: 998 VHSALRGHGDILQYL 1012
Score = 29.3 bits (64), Expect = 8.2
Identities = 22/62 (35%), Positives = 29/62 (46%), Gaps = 10/62 (16%)
Query: 147 RRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDE--NGYTALTWAARQGHKNIVLKLLEL 204
R L TP + +V LL+ GA VN + E N L + GH+ +V LLE
Sbjct: 898 RNLYTP--------NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEF 949
Query: 205 GA 206
GA
Sbjct: 950 GA 951
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 81.6 bits (200), Expect = 1e-15
Identities = 58/175 (33%), Positives = 96/175 (54%), Gaps = 9/175 (5%)
Query: 53 AMTIGDVSLVQELL----DSGISVD-SNFQYGWTPLMYAASVANAELVRVLLDRGANASF 107
A ++G S+VQ LL + + V+ ++ +G T L AA E+ +LL GA S
Sbjct: 1048 AASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVS- 1106
Query: 108 EKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVAL 167
+++ + C+A QI V LLL R D N++ ++ TP+M AA +GH V
Sbjct: 1107 RTNRRGVPPLFCAARQGHWQI---VRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEF 1163
Query: 168 LVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIA 222
L++ GA +++ D+ G +AL+WA +GH+ +V L+E GA K+G+ P ++A
Sbjct: 1164 LLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLA 1218
Score = 75.1 bits (183), Expect = 1e-13
Identities = 51/152 (33%), Positives = 78/152 (51%), Gaps = 8/152 (5%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSI 114
G + + + LL G +V + G PL AA + ++VR+LL+RG N S ++ + +
Sbjct: 1090 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1149
Query: 115 LITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAE 174
++ AC H L VE LLS+ A + + ++ + +A GH VV LV GA
Sbjct: 1150 MVAACEGH------LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAA 1203
Query: 175 VNTQDENGYTALTWAARQGHKNIVLKLLELGA 206
++ D+NG T L AA G VL L+E GA
Sbjct: 1204 IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGA 1235
Score = 60.8 bits (146), Expect = 3e-09
Identities = 58/213 (27%), Positives = 85/213 (39%), Gaps = 41/213 (19%)
Query: 56 IGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASF--EKDKQS 113
+G +V LL+ G +D + G T L YAA+ + +LV +L +G +K + +
Sbjct: 945 LGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCA 1004
Query: 114 ILITACSAHGSEEQ-ILKC---------------------------------VELLLSRN 139
++ +A HG Q +L C V+ LL
Sbjct: 1005 LVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGME 1064
Query: 140 ADPNVACRRL-----MTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGH 194
+ V T + AA G +V LL+ HGA V+ + G L AARQGH
Sbjct: 1065 KEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGH 1124
Query: 195 KNIVLKLLELGANKMLQTKDGKMPSEIAKRNKH 227
IV LLE G + L K G+ P +A H
Sbjct: 1125 WQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1157
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 91 NAELVRVLLDRGANASFEKDKQSILITAC-SAHGSEEQILKCVELLLSRNADPNVACRRL 149
N ++ R+L+ GAN ++ + + C +H E++ V LLL A +
Sbjct: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEV---VTLLLEFGACLDGTSENG 968
Query: 150 MTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLL 202
MT + YAA GH ++V LL G V+ D+ G AL +A +GH +I+ LL
Sbjct: 969 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1021
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/75 (34%), Positives = 36/75 (48%)
Query: 160 GHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPS 219
GH +VV LL+ GA ++ ENG TAL +AA GH +V L + G K G+
Sbjct: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
Query: 220 EIAKRNKHHEIFNLL 234
+ H +I L
Sbjct: 1006 VHSALRGHGDILQYL 1020
Score = 29.3 bits (64), Expect = 8.2
Identities = 22/62 (35%), Positives = 29/62 (46%), Gaps = 10/62 (16%)
Query: 147 RRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDE--NGYTALTWAARQGHKNIVLKLLEL 204
R L TP + +V LL+ GA VN + E N L + GH+ +V LLE
Sbjct: 906 RNLYTP--------NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEF 957
Query: 205 GA 206
GA
Sbjct: 958 GA 959
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 79.3 bits (194), Expect = 7e-15
Identities = 67/232 (28%), Positives = 102/232 (43%), Gaps = 30/232 (12%)
Query: 6 LRGLPVAGGGESSESEDDGWEIGYLDRTSQKLKRLLPIEEKKEKFKKAMTIGDVSLVQEL 65
L L +A G +++ ++DGW P+ + GD + L
Sbjct: 410 LCALLLAHGADANRVDEDGWA---------------PLHFAAQN-------GDDGTARLL 447
Query: 66 LDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEK--DKQSILITACSAHG 123
LD G VD+ + GWTPL AA + R+L+ R A+ + + K + + A H
Sbjct: 448 LDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHV 507
Query: 124 SEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGY 183
S V+LL S+ A+ + R L TP+ A G + + L+ GA + D++GY
Sbjct: 508 S------LVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGY 561
Query: 184 TALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLS 235
L AA +G I LL GA+ L T G P +A H EI +LL+
Sbjct: 562 GPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLA 613
Score = 65.9 bits (159), Expect = 8e-11
Identities = 41/114 (35%), Positives = 59/114 (51%), Gaps = 4/114 (3%)
Query: 121 AHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDE 180
A GS EQ V LLL+ D + TP++ AA+D + ALL+AHGA+ N DE
Sbjct: 371 AQGSVEQ----VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDE 426
Query: 181 NGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+G+ L +AA+ G LL+ GA Q ++G P +A +N + LL
Sbjct: 427 DGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
Score = 64.3 bits (155), Expect = 2e-10
Identities = 51/178 (28%), Positives = 81/178 (45%), Gaps = 4/178 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G + + LL G S++ GWTPL AA + E++ +L + AN +
Sbjct: 571 GKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+ HG E V LL ADPN A + TP+ A + V L+ H A V+
Sbjct: 631 HLAARHGEEA----VVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH 686
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+++ G+T AA +G+ I+ L+E GA +Q P ++A R++ I + L
Sbjct: 687 ARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
Score = 62.4 bits (150), Expect = 9e-10
Identities = 53/184 (28%), Positives = 85/184 (46%), Gaps = 8/184 (4%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDK- 111
A+ G V +Q LL SG D+ Q G+ PL AA+ + ++LL GA+ +
Sbjct: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG 593
Query: 112 -QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVA 170
+ + A H L+ + LL +A+ TP+ AAR G VV+ L+
Sbjct: 594 WTPLHLAAYKGH------LEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQ 647
Query: 171 HGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEI 230
GA+ N +++G+T L A ++ V+ LLE AN + K G P+ +A + I
Sbjct: 648 CGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAI 707
Query: 231 FNLL 234
+L
Sbjct: 708 LKVL 711
Score = 59.7 bits (143), Expect = 6e-09
Identities = 45/157 (28%), Positives = 72/157 (45%), Gaps = 8/157 (5%)
Query: 81 TPLMYAASVANAELVRVLLDRGANASFEKDK--QSILITACSAHGSEEQILKCVELLLSR 138
TPL + + + E VR+LL + + +LI A ++Q LLL+
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAA------QDQQPDLCALLLAH 417
Query: 139 NADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIV 198
AD N P+ +AA++G LL+ HGA V+ Q+ G+T L AA+ +N+
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477
Query: 199 LKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLS 235
L+ A+ L +GK P +A H + LL+
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLT 514
Score = 58.2 bits (139), Expect = 2e-08
Identities = 57/197 (28%), Positives = 87/197 (44%), Gaps = 7/197 (3%)
Query: 45 EKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA- 103
E K A G VSLV+ L G +D+ + TPL A ++ LL GA
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAV 552
Query: 104 NASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQ 163
+ ++ L TA +A G + L C ++LL A + + TP+ AA GH +
Sbjct: 553 PDALDQSGYGPLHTA-AARG---KYLIC-KMLLRYGASLELPTHQGWTPLHLAAYKGHLE 607
Query: 164 VVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIA- 222
++ LL A + +T L AAR G + +V LL+ GA+ + G P +A
Sbjct: 608 IIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAV 667
Query: 223 KRNKHHEIFNLLSFTLN 239
+R+ + NLL N
Sbjct: 668 QRSTFLSVINLLEHHAN 684
Score = 44.7 bits (104), Expect = 2e-04
Identities = 25/76 (32%), Positives = 39/76 (51%)
Query: 150 MTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKM 209
+TP+ + G + V LL+AH +V+ Q +GYT L AA+ ++ LL GA+
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 210 LQTKDGKMPSEIAKRN 225
+DG P A +N
Sbjct: 423 RVDEDGWAPLHFAAQN 438
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 79.0 bits (193), Expect = 9e-15
Identities = 55/179 (30%), Positives = 90/179 (50%), Gaps = 6/179 (3%)
Query: 45 EKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGAN 104
EK+ A +GD +++ L+ SG V++ TPL A + + E V+VLL A+
Sbjct: 40 EKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSAD 99
Query: 105 ASF-EKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQ 163
+ +K+ Q+ L A + + +KC E L+ ++ NV+ R T + +AA GH +
Sbjct: 100 VNARDKNWQTPLHIAAA-----NKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGE 154
Query: 164 VVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIA 222
+V LL++ GA +N D+ A+ WAA GH +V L+ GA + K P A
Sbjct: 155 MVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAA 213
Score = 78.6 bits (192), Expect = 1e-14
Identities = 55/172 (31%), Positives = 84/172 (48%), Gaps = 7/172 (4%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKD 110
A + G +S+V+ LLD G+ ++ YG TPL A +V L+D GA N EK
Sbjct: 213 AASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKG 272
Query: 111 KQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVA 170
+ A S HG+ C+ELL+ AD N+ + TP+ A G ++
Sbjct: 273 FTPLHFAAASTHGA-----LCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQ 327
Query: 171 HGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIA 222
GA ++ +D+NG T L AAR GH+ ++ L+ GA+ + G P +A
Sbjct: 328 SGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLA 379
Score = 68.2 bits (165), Expect = 2e-11
Identities = 61/182 (33%), Positives = 89/182 (48%), Gaps = 20/182 (10%)
Query: 61 LVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSIL----I 116
LVQ LLD + S G TPL AA + E V VL+++GA+ K IL I
Sbjct: 569 LVQSLLDLDVRNSS----GRTPLDLAAFKGHVECVDVLINQGASILV---KDYILKRTPI 621
Query: 117 TACSAHGSEEQILKCVELLLSRNADP----NVACRRLMTPIMYAARDGHTQVVALLVAHG 172
A + +G E C+ LL+ NA+P ++ TP+M + +GHT V L+ G
Sbjct: 622 HAAATNGHSE----CLRLLIG-NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKG 676
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFN 232
A V+ +D+ G TAL A GH+ V LL+ GA +L+ G+ P ++ H +
Sbjct: 677 ANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLG 736
Query: 233 LL 234
L
Sbjct: 737 AL 738
Score = 63.5 bits (153), Expect = 4e-10
Identities = 56/183 (30%), Positives = 81/183 (44%), Gaps = 4/183 (2%)
Query: 52 KAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDK 111
+A+ GD V+ L+ V+ TPL AA + +AE++ +L+ GA + + K
Sbjct: 14 QAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSK 73
Query: 112 QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAH 171
+ A SEE V++LL +AD N + TP+ AA + + LV
Sbjct: 74 WLTPLHRAVASCSEE----AVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
Query: 172 GAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIF 231
+ VN D G TAL AA GH +V LL GAN K + A H E+
Sbjct: 130 LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV 189
Query: 232 NLL 234
LL
Sbjct: 190 KLL 192
Score = 60.8 bits (146), Expect = 3e-09
Identities = 48/186 (25%), Positives = 86/186 (46%), Gaps = 11/186 (5%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A +G + +V+ L+ G V + +TPL AAS +V+ LLD G + +
Sbjct: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
Query: 113 SILITACSAHGSE---EQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQV-VALL 168
+ + +G + +++ C ++ +N + TP+ +AA H + + LL
Sbjct: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKN-------EKGFTPLHFAAASTHGALCLELL 292
Query: 169 VAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHH 228
V +GA+VN + ++G T L A G + +++ GA + K+G P IA R H
Sbjct: 293 VGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE 352
Query: 229 EIFNLL 234
+ N L
Sbjct: 353 LLINTL 358
Score = 60.8 bits (146), Expect = 3e-09
Identities = 52/164 (31%), Positives = 74/164 (45%), Gaps = 5/164 (3%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A G L+ L+ SG +G PL AA ++ R LL G + D
Sbjct: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
+ A +A G+ L+C+ LLL+ AD N + +P+ YAA + + Q + LV G
Sbjct: 406 RTCLHAAAAGGN----LECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSG 461
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLK-LLELGANKMLQTKDG 215
A VN DE G T L +AA L+ LL AN ++ K G
Sbjct: 462 ASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQG 505
Score = 59.7 bits (143), Expect = 6e-09
Identities = 49/129 (37%), Positives = 61/129 (47%), Gaps = 6/129 (4%)
Query: 59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASF---EKDKQSIL 115
V +Q LL V+S G TPLM AA V +L+ A+A + K + L
Sbjct: 836 VECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVS-SASAELTLQDNSKNTAL 894
Query: 116 ITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEV 175
ACS G E L +E + RN N L TP+ AAR+G T VV L+ GA V
Sbjct: 895 HLACSK-GHETSALLILEKITDRNLI-NATNAALQTPLHVAARNGLTMVVQELLGKGASV 952
Query: 176 NTQDENGYT 184
DENGYT
Sbjct: 953 LAVDENGYT 961
Score = 57.0 bits (136), Expect = 4e-08
Identities = 52/159 (32%), Positives = 74/159 (46%), Gaps = 24/159 (15%)
Query: 80 WTPLMYAASVANAELVRVLLDR-GA---NASFEKDKQSILITACSAHGSEEQILKCVELL 135
++PL A N +L+D GA NA+ K + + A + H ++C++LL
Sbjct: 789 FSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDH------VECLQLL 842
Query: 136 LSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG-AEVNTQDENGYTALTWAARQGH 194
LS NA N TP+M AA +G T V +LV+ AE+ QD + TAL A +GH
Sbjct: 843 LSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH 902
Query: 195 KNIVLKLLEL--------GANKMLQTKDGKMPSEIAKRN 225
+ L +LE N LQT P +A RN
Sbjct: 903 ETSALLILEKITDRNLINATNAALQT-----PLHVAARN 936
Score = 52.8 bits (125), Expect = 7e-07
Identities = 48/184 (26%), Positives = 81/184 (44%), Gaps = 11/184 (5%)
Query: 57 GDVSLVQELLDSGISVDSN----FQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
G + ++ LL S S+D+N +G+T L +A + V +LL++ E +
Sbjct: 730 GHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAF 789
Query: 113 SILITAC--SAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVA 170
S L A G+ E ++ + + D + TP+ AA H + + LL++
Sbjct: 790 SPLHCAVINDNEGAAEMLIDTLGASIVNATDS-----KGRTPLHAAAFTDHVECLQLLLS 844
Query: 171 HGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEI 230
H A+VN+ D G T L AA G N V L+ + ++ + K + +K HE
Sbjct: 845 HNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHET 904
Query: 231 FNLL 234
LL
Sbjct: 905 SALL 908
Score = 52.4 bits (124), Expect = 9e-07
Identities = 54/189 (28%), Positives = 85/189 (44%), Gaps = 16/189 (8%)
Query: 65 LLDSGISVDSNFQYGWTPLMYAA-SVANAELVRVLLDRGANASFEKDKQSILITACSAHG 123
L+ SG SV+ + G TPL YAA S + + + LL AN +DKQ SA
Sbjct: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGI-RDKQGYNAVHYSAAY 515
Query: 124 SEEQILKCV------ELLLSRNADPNVAC---RRLMTPIMYAARDGHTQVVALLVAHGAE 174
L+ + ++L+ + ++ R ++P+ AA GH Q + +LV +
Sbjct: 516 GHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLD 575
Query: 175 VNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKD---GKMPSEIAKRNKHHEIF 231
++ ++ +G T L AA +GH V L+ GA+ + KD + P A N H E
Sbjct: 576 LDVRNSSGRTPLDLAAFKGHVECVDVLINQGAS--ILVKDYILKRTPIHAAATNGHSECL 633
Query: 232 NLLSFTLNP 240
LL P
Sbjct: 634 RLLIGNAEP 642
Score = 49.3 bits (116), Expect = 8e-06
Identities = 44/151 (29%), Positives = 59/151 (39%), Gaps = 41/151 (27%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G V LL+ G +VD+ ++G R L RGA E
Sbjct: 664 GHTDCVYSLLNKGANVDAKDKWG----------------RTALHRGAVTGHE-------- 699
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
+CV+ LL A + R TPI +A GH V+ L+ A ++
Sbjct: 700 -------------ECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMD 746
Query: 177 ----TQDENGYTALTWAARQGHKNIVLKLLE 203
T D +GYTAL WA GH+ V LLE
Sbjct: 747 ANPATADNHGYTALHWACYNGHETCVELLLE 777
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 77.8 bits (190), Expect = 2e-14
Identities = 57/180 (31%), Positives = 90/180 (50%), Gaps = 4/180 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G+V ++++LL G SVD GW P+ AA + E +++L++ A++S K
Sbjct: 21 GNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLIN--ADSSENYIKMKTFE 78
Query: 117 TACSAH-GSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEV 175
C+ H + + K V++LL ADPN TP+ A +G V+ LL+ HGA V
Sbjct: 79 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 138
Query: 176 N-TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
N + G+ +L A+ Q + I+ LL GANK Q G P +A + E ++L
Sbjct: 139 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 198
Score = 65.1 bits (157), Expect = 1e-10
Identities = 52/184 (28%), Positives = 90/184 (48%), Gaps = 5/184 (2%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A + G +VQ LL++G ++ TPL A +++R+LL GAN +
Sbjct: 86 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVN---GSH 142
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
S+ S ++ + ++LLL + A+ +TP+ AA+ G + +++L++ G
Sbjct: 143 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 202
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDG--KMPSEIAKRNKHHEI 230
A VN Q + T L AA++GH V LL GA+ L + ++P A + H +I
Sbjct: 203 ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKI 262
Query: 231 FNLL 234
+LL
Sbjct: 263 LDLL 266
Score = 62.8 bits (151), Expect = 7e-10
Identities = 47/151 (31%), Positives = 74/151 (49%), Gaps = 8/151 (5%)
Query: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEK-DKQSILI 116
+ +++ LL G + + +G TPL AA E + +L+ GAN + + DK + L
Sbjct: 158 NAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLF 217
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRR--LMTPIMYAARDGHTQVVALLVAHGAE 174
A ++E KCVELLLS ADP++ C PI AA+ GHT+++ LL+
Sbjct: 218 IA-----AQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNR 272
Query: 175 VNTQDENGYTALTWAARQGHKNIVLKLLELG 205
N + + A GH++ + LL G
Sbjct: 273 ACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 303
Score = 43.5 bits (101), Expect = 4e-04
Identities = 38/121 (31%), Positives = 56/121 (46%), Gaps = 5/121 (4%)
Query: 119 CSAHG--SEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLV-AHGAE- 174
CS G + E +K + LL + +VA R PI AA + + +L+ A +E
Sbjct: 11 CSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN 70
Query: 175 -VNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNL 233
+ + G+ AL AA QGH IV LLE GA+ T + P +A N ++ L
Sbjct: 71 YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRL 130
Query: 234 L 234
L
Sbjct: 131 L 131
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 77.8 bits (190), Expect = 2e-14
Identities = 59/202 (29%), Positives = 87/202 (43%), Gaps = 11/202 (5%)
Query: 81 TPLMYAASVANAELVRVLLDRGA---NASFEKDKQSILITACSAHGSEEQILKCVELLLS 137
T L AA+ N L+ +LL+ N S E ++ A + H CV LLLS
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTD------CVRLLLS 765
Query: 138 RNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNI 197
A N A + TP+ AA GH + V LL+++ A +N + G T L A + G+K
Sbjct: 766 AEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKEC 825
Query: 198 VLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQQLTKEDTICKI 257
+ LLE G N+ ++T DG P A + + LL + P G +E++ +
Sbjct: 826 IKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHG--NSFNEEESESSV 883
Query: 258 LTTDSDREKDHIFSSYTAFGDL 279
D E S DL
Sbjct: 884 FDLDGGEESPEGISKPVVPADL 905
Score = 30.8 bits (68), Expect = 2.8
Identities = 44/208 (21%), Positives = 81/208 (38%), Gaps = 14/208 (6%)
Query: 64 ELLDSGISVDSNFQY----GWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITAC 119
E ++ IS D+N + G TPL A N E +++LL+ G N S + + A
Sbjct: 791 ECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAA 850
Query: 120 SAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQD 179
G+ + + + + + + + + + ++ V +N +
Sbjct: 851 VDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHAN 910
Query: 180 ENGYTALTWAARQGHKNIVLKLLELGA-NKMLQTKDGKMPSEIAKRNKHH--EIFNLLSF 236
G+TA AA +G KN + L G + K + ++A + H E N L
Sbjct: 911 REGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRTVHDVATDDCKHLLENLNALKI 970
Query: 237 TLNPLEGKLQ-------QLTKEDTICKI 257
L G+++ L E+TIC +
Sbjct: 971 PLRISVGEIEPSNYGSDDLECENTICAL 998
Score = 30.4 bits (67), Expect = 3.7
Identities = 30/123 (24%), Positives = 51/123 (41%), Gaps = 14/123 (11%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVL----LDRGANASFEKDKQ 112
G+ ++ LL++G + GWTP+ A N + +++L + N+ E++ +
Sbjct: 821 GNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESE 880
Query: 113 SILITACSAHGSEEQILKCV---ELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLV 169
S + S E I K V +L+ N A R T AA G + +L
Sbjct: 881 SSVFDLDGGEESPEGISKPVVPADLI-------NHANREGWTAAHIAASKGFKNCLEILC 933
Query: 170 AHG 172
HG
Sbjct: 934 RHG 936
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 77.8 bits (190), Expect = 2e-14
Identities = 53/179 (29%), Positives = 93/179 (51%), Gaps = 5/179 (2%)
Query: 57 GDVSLVQELLDSG-ISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSIL 115
G+++L++ LL+SG + VD +G T LM AA + + VR L+ +GA+ + +++ +
Sbjct: 23 GNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTA 82
Query: 116 ITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEV 175
+ + G + V L A + T ++ A++ GH QVV L+ HGA +
Sbjct: 83 LFFAAQQGHND----VVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
Query: 176 NTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+ Q +G TAL AA+ G+ +++ LL GA +DG P IA + H E+ ++
Sbjct: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVM 197
Score = 71.6 bits (174), Expect = 1e-12
Identities = 52/182 (28%), Positives = 87/182 (47%), Gaps = 5/182 (2%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116
G + V+EL+ G ++ + G T L +AA + ++VR L GA+ F +
Sbjct: 57 GHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTAL 116
Query: 117 TACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
A S +G ++ VE LL A+ + T + AA+ G+ V+ LL+A GA+VN
Sbjct: 117 LAASQYGH----MQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVN 172
Query: 177 TQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMP-SEIAKRNKHHEIFNLLS 235
++G L A++ GH +V +L GA++ DG + A + + I LL
Sbjct: 173 QPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLK 232
Query: 236 FT 237
F+
Sbjct: 233 FS 234
Score = 63.9 bits (154), Expect = 3e-10
Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 7/158 (4%)
Query: 81 TPL----MYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVELLL 136
TPL +AA N L+++LL+ G +D + +A+ + CV L+
Sbjct: 10 TPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGH---IDCVRELV 66
Query: 137 SRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKN 196
+ AD N+ T + +AA+ GH VV L GA + ++G TAL A++ GH
Sbjct: 67 LQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQ 126
Query: 197 IVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
+V LL+ GAN Q DG +A + + ++ LL
Sbjct: 127 VVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLL 164
Score = 63.2 bits (152), Expect = 5e-10
Identities = 48/174 (27%), Positives = 80/174 (45%), Gaps = 5/174 (2%)
Query: 53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQ 112
A G + +V+ LL G ++ G T L AA +++R+LL GA + +
Sbjct: 119 ASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDG 178
Query: 113 SILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHG 172
+ + S G E V ++L R AD + A T ++ AA G+ V+ L+
Sbjct: 179 TAPLWIASQMGHSE----VVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFS 234
Query: 173 AEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNK 226
+ +NG +AL A G+ V LLE GA+ L+ K ++P+E+ K +
Sbjct: 235 PTLGIL-KNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNER 287
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 75.5 bits (184), Expect = 1e-13
Identities = 49/181 (27%), Positives = 89/181 (49%), Gaps = 8/181 (4%)
Query: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASF-EKDKQSIL 115
G VS V+ LL++ VD+ TPL A + + ++++ L+ GA ++D S+L
Sbjct: 368 GHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLL 427
Query: 116 ITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEV 175
A ++ ++L+ +PNV TP+ AA G+ +A+L+ + A+
Sbjct: 428 HWAALGGNAD-----VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482
Query: 176 NTQDENGYTALTWAARQGHKNIVLKLLELGA--NKMLQTKDGKMPSEIAKRNKHHEIFNL 233
N QD+ G TAL W+ G+ + + LL+ A N+M ++ P + A + HE+
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQF 542
Query: 234 L 234
+
Sbjct: 543 M 543
Score = 61.2 bits (147), Expect = 2e-09
Identities = 50/173 (28%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 57 GDVSLVQELLDSGISV-DSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSIL 115
GD +Q L+ ++ D Q+G TPLMY + LL GA+ + Q
Sbjct: 25 GDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTA 84
Query: 116 ITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGA-- 173
+ + G+ + ++LLL+R A+ MTP+ R + +ALL+ A
Sbjct: 85 LHLAAQKGN----YRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140
Query: 174 EVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNK 226
EV+TQD+N TAL W+A + V L++ +N + +GK+P A +K
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHK 193
Score = 59.3 bits (142), Expect = 7e-09
Identities = 45/154 (29%), Positives = 74/154 (48%), Gaps = 11/154 (7%)
Query: 73 DSNFQYGWTPLMYAASVANAELVRVLL----DRGANASFEKDKQSILITACSAHGSEEQI 128
DS+ + G T M+AA + +++R +L D N + + ++ A S H S
Sbjct: 317 DSDLE-GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVST--- 372
Query: 129 LKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTW 188
V+LLL NA + TP+ A GH V+ L+ GA V+ D++G++ L W
Sbjct: 373 ---VKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHW 429
Query: 189 AARQGHKNIVLKLLELGANKMLQTKDGKMPSEIA 222
AA G+ ++ L+E N +Q G+ P + A
Sbjct: 430 AALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463
Score = 42.7 bits (99), Expect = 7e-04
Identities = 34/153 (22%), Positives = 62/153 (40%), Gaps = 37/153 (24%)
Query: 53 AMTIGDVSLVQELLD-SGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDK 111
A+ G+V++V L ++ S TPL +AA + +A++V +LL+R + + D
Sbjct: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
Query: 112 QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAH 171
Q TP+ YAA+ + V + + H
Sbjct: 288 QGA------------------------------------TPLHYAAQSNFAETVKVFLKH 311
Query: 172 GAEVNTQDENGYTALTWAARQGHKNIVLKLLEL 204
+ + D G T+ WAA +G +++ +L L
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSL 344
Score = 42.7 bits (99), Expect = 7e-04
Identities = 37/157 (23%), Positives = 66/157 (42%), Gaps = 39/157 (24%)
Query: 52 KAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDK 111
+A +G ++Q L+ G VD Q G + L +AA NA++ ++L++ N + + D
Sbjct: 396 RACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQ-DY 454
Query: 112 QSILITACSAHGSEEQILKCVELLLSRNADPNV-------------------ACRRLM-- 150
C+A+G + C+ +L+ NADPN+ A + L+
Sbjct: 455 AGRTPLQCAAYGG---YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDF 511
Query: 151 --------------TPIMYAARDGHTQVVALLVAHGA 173
TP+ YA +V+ ++ HGA
Sbjct: 512 AAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 41.2 bits (95), Expect = 0.002
Identities = 29/104 (27%), Positives = 46/104 (44%)
Query: 151 TPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKML 210
TP+MY L+ GA+VN D + TAL AA++G+ + LL AN M
Sbjct: 50 TPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQ 109
Query: 211 QTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQQLTKEDTI 254
+ + P + R++ + LL + P E Q K+ +
Sbjct: 110 KDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTAL 153
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,609,967
Number of Sequences: 37866
Number of extensions: 701525
Number of successful extensions: 5504
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 330
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 2580
Number of HSP's gapped (non-prelim): 1736
length of query: 475
length of database: 18,247,518
effective HSP length: 106
effective length of query: 369
effective length of database: 14,233,722
effective search space: 5252243418
effective search space used: 5252243418
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.