Search of human proteins with 18490982

Search of human proteins with 18490982

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18490982 R-spondin 3 [Homo sapiens]
         (272 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18490982 R-spondin 3 [Homo sapiens]                                586   e-168
gi|84490388 R-spondin1 [Homo sapiens]                                 252   2e-67
gi|222446611 R-spondin family, member 2 [Homo sapiens]                228   3e-60
gi|83722284 R-spondin family, member 4 isoform 1 precursor [Homo...   182   2e-46
gi|90970328 R-spondin family, member 4 isoform 2 precursor [Homo...   127   1e-29
gi|20336184 paired basic amino acid cleaving system 4 isoform h ...    65   8e-11
gi|20336182 paired basic amino acid cleaving system 4 isoform g ...    65   8e-11
gi|4505577 paired basic amino acid cleaving system 4 isoform a p...    65   8e-11
gi|20336180 paired basic amino acid cleaving system 4 isoform b ...    65   8e-11
gi|108773804 Fraser syndrome 1 [Homo sapiens]                          58   1e-08
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro...    56   3e-08
gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo ...    55   5e-08
gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo ...    55   5e-08
gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]    55   5e-08
gi|239755070 PREDICTED: similar to proprotein convertase subtili...    55   9e-08
gi|150170672 thrombospondin, type I, domain containing 7A [Homo ...    50   2e-06
gi|31657140 insulin receptor-related receptor precursor [Homo sa...    47   1e-05
gi|111125011 WNT inhibitory factor 1 precursor [Homo sapiens]          45   7e-05
gi|122937257 thrombospondin, type I, domain containing 7B [Homo ...    45   7e-05
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...    45   9e-05
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            43   3e-04
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...    43   3e-04
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]    43   3e-04
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi...    42   6e-04
gi|118572606 hemicentin 1 [Homo sapiens]                               42   6e-04
gi|168229156 NFKB activating protein [Homo sapiens]                    42   7e-04
gi|190341087 spondin 2, extracellular matrix protein [Homo sapiens]    41   0.001
gi|6912682 spondin 2, extracellular matrix protein [Homo sapiens]      41   0.001
gi|209969800 RPE-spondin [Homo sapiens]                                40   0.002
gi|116734855 cysteine-rich with EGF-like domains 1 isoform 3 [Ho...    40   0.002

>gi|18490982 R-spondin 3 [Homo sapiens]
          Length = 272

 Score =  586 bits (1510), Expect = e-168
 Identities = 272/272 (100%), Positives = 272/272 (100%)

Query: 1   MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR 60
           MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR
Sbjct: 1   MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR 60

Query: 61  LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL 120
           LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL
Sbjct: 61  LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL 120

Query: 121 HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII 180
           HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII
Sbjct: 121 HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII 180

Query: 181 QHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLES 240
           QHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLES
Sbjct: 181 QHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLES 240

Query: 241 SKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH 272
           SKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH
Sbjct: 241 SKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH 272


>gi|84490388 R-spondin1 [Homo sapiens]
          Length = 263

 Score =  252 bits (644), Expect = 2e-67
 Identities = 116/252 (46%), Positives = 159/252 (63%), Gaps = 15/252 (5%)

Query: 11  IILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGM 70
           ++L++     S    +G+RQRR+    SQ C  GC  CS+ NGCL C P+LF  LER  +
Sbjct: 10  LVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDI 69

Query: 71  KQIGVCLSSCPSGYYGTRYPDINKCTKCKAD-CDTCFNKNFCTKCKSGFYLHLGKCLDNC 129
           +Q+GVCL SCP GY+  R PD+NKC KCK + C+ CF+ NFCTKCK G YLH G+C   C
Sbjct: 70  RQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPAC 129

Query: 130 PEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNL 189
           PEG  A N TMEC S   CE+SEW+PW PC+KK + CGF+RG+E R R ++  P      
Sbjct: 130 PEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAA 189

Query: 190 CPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKG----ESKEAIPDSKSLESSKEIP 245
           C  T ETR+CTV+R  C +G++ +KG + +R+  N+     ESKEA   S+         
Sbjct: 190 CSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLARKESKEAGAGSR--------- 240

Query: 246 EQRENKQQQKKR 257
            +R+ +QQQ+++
Sbjct: 241 -RRKGQQQQQQQ 251


>gi|222446611 R-spondin family, member 2 [Homo sapiens]
          Length = 243

 Score =  228 bits (582), Expect = 3e-60
 Identities = 107/226 (47%), Positives = 143/226 (63%), Gaps = 5/226 (2%)

Query: 1   MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR 60
           M  RL S+  IILN M+Y   Q  +R RR +R     +  C+G C +CS  NGC  C+ +
Sbjct: 1   MQFRLFSFALIILNCMDYSHCQG-NRWRRSKRASYVSNPICKG-CLSCSKDNGCSRCQQK 58

Query: 61  LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKAD-CDTCFNKNFCTKCKSGFY 119
           LFF L R GM+Q G CL SCPSGYYG R PD+N+C +C+ + CD+CF+K+FCTKCK GFY
Sbjct: 59  LFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFY 118

Query: 120 LHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREI 179
           LH G+C D CP+G      TMECV    CEV  W+ W  C++  +TCGFK G ETR R+I
Sbjct: 119 LHRGRCFDECPDGFAPLEETMECVE--GCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQI 176

Query: 180 IQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNK 225
           ++ P     LCP   E+R+C +  + C  G+R  K +E++ KK  +
Sbjct: 177 VKKPVKDTILCPTIAESRRCKMTMRHCPGGKRTPKAKEKRNKKKKR 222


>gi|83722284 R-spondin family, member 4 isoform 1 precursor [Homo
           sapiens]
          Length = 234

 Score =  182 bits (463), Expect = 2e-46
 Identities = 87/201 (43%), Positives = 123/201 (61%), Gaps = 8/201 (3%)

Query: 28  RRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGT 87
           RR++++   +   C G C  CS+ NGC +C+ RLF  + R G++Q G CL  CP GY+G 
Sbjct: 22  RRKKQVGTGLGGNCTG-CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGI 80

Query: 88  RYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVH 147
           R  ++N+C KC A C++CF+++FC +CK  FYL+ GKCL  CP G  A+ +T EC     
Sbjct: 81  RGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQG--E 138

Query: 148 CEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQ 207
           CE+  W  WSPCT  GKTCG   G E+RVRE  +    +   C   +E+RKC +QR  C 
Sbjct: 139 CELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPIQR-PC- 196

Query: 208 KGERG---KKGRERKRKKPNK 225
            GER    KKGR+ +R + ++
Sbjct: 197 PGERSPGQKKGRKDRRPRKDR 217


>gi|90970328 R-spondin family, member 4 isoform 2 precursor [Homo
           sapiens]
          Length = 172

 Score =  127 bits (319), Expect = 1e-29
 Identities = 52/115 (45%), Positives = 76/115 (66%), Gaps = 1/115 (0%)

Query: 28  RRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGT 87
           RR++++   +   C G C  CS+ NGC +C+ RLF  + R G++Q G CL  CP GY+G 
Sbjct: 22  RRKKQVGTGLGGNCTG-CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGI 80

Query: 88  RYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMEC 142
           R  ++N+C KC A C++CF+++FC +CK  FYL+ GKCL  CP G  A+ +T EC
Sbjct: 81  RGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTREC 135


>gi|20336184 paired basic amino acid cleaving system 4 isoform h
           preproprotein [Homo sapiens]
          Length = 962

 Score = 64.7 bits (156), Expect = 8e-11
 Identities = 40/133 (30%), Positives = 54/133 (40%), Gaps = 22/133 (16%)

Query: 18  YIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNG--CLSCKPRLFFALERIGMKQIGV 75
           Y G   A R RR           C  GC TCS      CLSC+   +   E      +  
Sbjct: 724 YFGDTAARRCRR-----------CHKGCETCSSRAATQCLSCRRGFYHHQE------MNT 766

Query: 76  CLSSCPSGYYGTRYPDINKCTKCKADCDTCFNK-NFCTKCKSGFYLHLGKCLDNCPEGLE 134
           C++ CP+G+Y         C KC   C  C ++   CT CK GF L  G C+ +C  G  
Sbjct: 767 CVTLCPAGFYADESQ--KNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTY 824

Query: 135 ANNHTMECVSIVH 147
            ++  + C    H
Sbjct: 825 FDSELIRCGECHH 837



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 17/115 (14%)

Query: 34  HPNVS-QGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDI 92
           HP    +GC G  A     + CL+C   + F+L  +  K    C+S CP GY+G      
Sbjct: 683 HPECGDKGCDGPNA-----DQCLNC---VHFSLGSV--KTSRKCVSVCPLGYFGD--TAA 730

Query: 93  NKCTKCKADCDTCFNK--NFCTKCKSGFYLH--LGKCLDNCPEGLEANNHTMECV 143
            +C +C   C+TC ++    C  C+ GFY H  +  C+  CP G  A+     C+
Sbjct: 731 RRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCL 785



 Score = 45.1 bits (105), Expect = 7e-05
 Identities = 29/95 (30%), Positives = 38/95 (40%), Gaps = 13/95 (13%)

Query: 41  CQGGCATCSDY-NGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCK 99
           C   C  C D    C  CK    F+L R      G C+  C  G Y     ++ +C +C 
Sbjct: 787 CHPSCKKCVDEPEKCTVCKEG--FSLAR------GSCIPDCEPGTYFDS--ELIRCGECH 836

Query: 100 ADCDTCFN--KNFCTKCKSGFYLHLGKCLDNCPEG 132
             C TC    +  C  C   F+ H  KC+  C EG
Sbjct: 837 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 871


>gi|20336182 paired basic amino acid cleaving system 4 isoform g
           preproprotein [Homo sapiens]
          Length = 975

 Score = 64.7 bits (156), Expect = 8e-11
 Identities = 40/133 (30%), Positives = 54/133 (40%), Gaps = 22/133 (16%)

Query: 18  YIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNG--CLSCKPRLFFALERIGMKQIGV 75
           Y G   A R RR           C  GC TCS      CLSC+   +   E      +  
Sbjct: 737 YFGDTAARRCRR-----------CHKGCETCSSRAATQCLSCRRGFYHHQE------MNT 779

Query: 76  CLSSCPSGYYGTRYPDINKCTKCKADCDTCFNK-NFCTKCKSGFYLHLGKCLDNCPEGLE 134
           C++ CP+G+Y         C KC   C  C ++   CT CK GF L  G C+ +C  G  
Sbjct: 780 CVTLCPAGFYADESQ--KNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTY 837

Query: 135 ANNHTMECVSIVH 147
            ++  + C    H
Sbjct: 838 FDSELIRCGECHH 850



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 17/115 (14%)

Query: 34  HPNVS-QGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDI 92
           HP    +GC G  A     + CL+C   + F+L  +  K    C+S CP GY+G      
Sbjct: 696 HPECGDKGCDGPNA-----DQCLNC---VHFSLGSV--KTSRKCVSVCPLGYFGD--TAA 743

Query: 93  NKCTKCKADCDTCFNK--NFCTKCKSGFYLH--LGKCLDNCPEGLEANNHTMECV 143
            +C +C   C+TC ++    C  C+ GFY H  +  C+  CP G  A+     C+
Sbjct: 744 RRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCL 798



 Score = 45.1 bits (105), Expect = 7e-05
 Identities = 29/95 (30%), Positives = 38/95 (40%), Gaps = 13/95 (13%)

Query: 41  CQGGCATCSDY-NGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCK 99
           C   C  C D    C  CK    F+L R      G C+  C  G Y     ++ +C +C 
Sbjct: 800 CHPSCKKCVDEPEKCTVCKEG--FSLAR------GSCIPDCEPGTYFDS--ELIRCGECH 849

Query: 100 ADCDTCFN--KNFCTKCKSGFYLHLGKCLDNCPEG 132
             C TC    +  C  C   F+ H  KC+  C EG
Sbjct: 850 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 884


>gi|4505577 paired basic amino acid cleaving system 4 isoform a
           preproprotein [Homo sapiens]
          Length = 969

 Score = 64.7 bits (156), Expect = 8e-11
 Identities = 40/133 (30%), Positives = 54/133 (40%), Gaps = 22/133 (16%)

Query: 18  YIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNG--CLSCKPRLFFALERIGMKQIGV 75
           Y G   A R RR           C  GC TCS      CLSC+   +   E      +  
Sbjct: 737 YFGDTAARRCRR-----------CHKGCETCSSRAATQCLSCRRGFYHHQE------MNT 779

Query: 76  CLSSCPSGYYGTRYPDINKCTKCKADCDTCFNK-NFCTKCKSGFYLHLGKCLDNCPEGLE 134
           C++ CP+G+Y         C KC   C  C ++   CT CK GF L  G C+ +C  G  
Sbjct: 780 CVTLCPAGFYADESQ--KNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTY 837

Query: 135 ANNHTMECVSIVH 147
            ++  + C    H
Sbjct: 838 FDSELIRCGECHH 850



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 17/115 (14%)

Query: 34  HPNVS-QGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDI 92
           HP    +GC G  A     + CL+C   + F+L  +  K    C+S CP GY+G      
Sbjct: 696 HPECGDKGCDGPNA-----DQCLNC---VHFSLGSV--KTSRKCVSVCPLGYFGD--TAA 743

Query: 93  NKCTKCKADCDTCFNK--NFCTKCKSGFYLH--LGKCLDNCPEGLEANNHTMECV 143
            +C +C   C+TC ++    C  C+ GFY H  +  C+  CP G  A+     C+
Sbjct: 744 RRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCL 798



 Score = 45.1 bits (105), Expect = 7e-05
 Identities = 29/95 (30%), Positives = 38/95 (40%), Gaps = 13/95 (13%)

Query: 41  CQGGCATCSDY-NGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCK 99
           C   C  C D    C  CK    F+L R      G C+  C  G Y     ++ +C +C 
Sbjct: 800 CHPSCKKCVDEPEKCTVCKEG--FSLAR------GSCIPDCEPGTYFDS--ELIRCGECH 849

Query: 100 ADCDTCFN--KNFCTKCKSGFYLHLGKCLDNCPEG 132
             C TC    +  C  C   F+ H  KC+  C EG
Sbjct: 850 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 884



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 28/119 (23%), Positives = 44/119 (36%), Gaps = 22/119 (18%)

Query: 41  CQGGCATC--SDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDI--NKCT 96
           C   C TC       C+ C     F   +        C+ +C  G+Y    P +    C 
Sbjct: 848 CHHTCGTCVGPGREECIHCAKNFHFHDWK--------CVPACGEGFYPEEMPGLPHKVCR 899

Query: 97  KCKADCDTCFNKNF-CTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWN 154
           +C  +C +C   +  C++CK+GF      C+          NHT        CE+ + N
Sbjct: 900 RCDENCLSCAGSSRNCSRCKTGFTQLGTSCI---------TNHTCSNADETFCEMVKSN 949


>gi|20336180 paired basic amino acid cleaving system 4 isoform b
           preproprotein [Homo sapiens]
          Length = 956

 Score = 64.7 bits (156), Expect = 8e-11
 Identities = 40/133 (30%), Positives = 54/133 (40%), Gaps = 22/133 (16%)

Query: 18  YIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNG--CLSCKPRLFFALERIGMKQIGV 75
           Y G   A R RR           C  GC TCS      CLSC+   +   E      +  
Sbjct: 724 YFGDTAARRCRR-----------CHKGCETCSSRAATQCLSCRRGFYHHQE------MNT 766

Query: 76  CLSSCPSGYYGTRYPDINKCTKCKADCDTCFNK-NFCTKCKSGFYLHLGKCLDNCPEGLE 134
           C++ CP+G+Y         C KC   C  C ++   CT CK GF L  G C+ +C  G  
Sbjct: 767 CVTLCPAGFYADESQ--KNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTY 824

Query: 135 ANNHTMECVSIVH 147
            ++  + C    H
Sbjct: 825 FDSELIRCGECHH 837



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 17/115 (14%)

Query: 34  HPNVS-QGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDI 92
           HP    +GC G  A     + CL+C   + F+L  +  K    C+S CP GY+G      
Sbjct: 683 HPECGDKGCDGPNA-----DQCLNC---VHFSLGSV--KTSRKCVSVCPLGYFGD--TAA 730

Query: 93  NKCTKCKADCDTCFNK--NFCTKCKSGFYLH--LGKCLDNCPEGLEANNHTMECV 143
            +C +C   C+TC ++    C  C+ GFY H  +  C+  CP G  A+     C+
Sbjct: 731 RRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCL 785



 Score = 45.1 bits (105), Expect = 7e-05
 Identities = 29/95 (30%), Positives = 38/95 (40%), Gaps = 13/95 (13%)

Query: 41  CQGGCATCSDY-NGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCK 99
           C   C  C D    C  CK    F+L R      G C+  C  G Y     ++ +C +C 
Sbjct: 787 CHPSCKKCVDEPEKCTVCKEG--FSLAR------GSCIPDCEPGTYFDS--ELIRCGECH 836

Query: 100 ADCDTCFN--KNFCTKCKSGFYLHLGKCLDNCPEG 132
             C TC    +  C  C   F+ H  KC+  C EG
Sbjct: 837 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 871



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 28/119 (23%), Positives = 44/119 (36%), Gaps = 22/119 (18%)

Query: 41  CQGGCATC--SDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDI--NKCT 96
           C   C TC       C+ C     F   +        C+ +C  G+Y    P +    C 
Sbjct: 835 CHHTCGTCVGPGREECIHCAKNFHFHDWK--------CVPACGEGFYPEEMPGLPHKVCR 886

Query: 97  KCKADCDTCFNKNF-CTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWN 154
           +C  +C +C   +  C++CK+GF      C+          NHT        CE+ + N
Sbjct: 887 RCDENCLSCAGSSRNCSRCKTGFTQLGTSCI---------TNHTCSNADETFCEMVKSN 936


>gi|108773804 Fraser syndrome 1 [Homo sapiens]
          Length = 4011

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 31/107 (28%), Positives = 42/107 (39%), Gaps = 10/107 (9%)

Query: 41   CQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKA 100
            C   C  C   + C  CK   F  LE         C+  C  GY+       +KCT C  
Sbjct: 1004 CDSYCLQCQGPHECTRCKGP-FLLLE-------AQCVQECGKGYFADHAK--HKCTACPQ 1053

Query: 101  DCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVH 147
             C  C +++ C  C  GF+L  G C+ NC  G   +     C   +H
Sbjct: 1054 GCLQCSHRDRCHLCDHGFFLKSGLCVYNCVPGFSVHTSNETCSGKIH 1100



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 32/101 (31%), Positives = 42/101 (41%), Gaps = 11/101 (10%)

Query: 42  QGGCATCSDYNGCLSC---KPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKC 98
           QG C+ C     C SC    PR     E+  +   G C+S CP GYY        +C  C
Sbjct: 555 QGTCSACDQ--SCDSCGPSSPRCLTCTEKTVLHD-GKCMSECPGGYYADA---TGRCKVC 608

Query: 99  KADCDTCF--NKNFCTKCKSGFYLHLGKCLDNCPEGLEANN 137
              C +C     + CT C     L  G CL  C EG  +++
Sbjct: 609 HNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDH 649



 Score = 51.2 bits (121), Expect = 9e-07
 Identities = 31/99 (31%), Positives = 41/99 (41%), Gaps = 14/99 (14%)

Query: 41  CQGGCATC--SDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKC 98
           C   CA C       CL+C+  L    +       G C SSC  G+Y  +      C+ C
Sbjct: 513 CHESCAGCWGPTEKHCLACRDPLHVLRD-------GGCESSCGKGFYNRQ----GTCSAC 561

Query: 99  KADCDTCFNKN-FCTKCKSGFYLHLGKCLDNCPEGLEAN 136
              CD+C   +  C  C     LH GKC+  CP G  A+
Sbjct: 562 DQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYAD 600



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 33/127 (25%), Positives = 49/127 (38%), Gaps = 17/127 (13%)

Query: 41  CQGGCATCSDY-NGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCK 99
           C   C TCS   + C  C+       +   + Q G C+ SC  G+Y       + C  C+
Sbjct: 421 CHPDCLTCSQSPDHCDLCQ-------DPTKLLQNGWCVHSCGLGFYQAG----SLCLACQ 469

Query: 100 ADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPC 159
             C TC +   C+ C+    +  G+C+  C +G   + H     S   C  S    W P 
Sbjct: 470 PQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRH-----SCAVCHESCAGCWGPT 524

Query: 160 TKKGKTC 166
            K    C
Sbjct: 525 EKHCLAC 531



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 31/111 (27%), Positives = 45/111 (40%), Gaps = 15/111 (13%)

Query: 36   NVSQGCQGGCATCSD--YNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDIN 93
            N  + C   C+ CS      CL C              Q G C+  C S +Y     D  
Sbjct: 953  NTCKECDWSCSACSGPLKTDCLQCMDGYVL--------QDGACVEQCLSSFY----QDSG 1000

Query: 94   KCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVS 144
             C KC + C  C   + CT+CK  F L   +C+  C +G  A++   +C +
Sbjct: 1001 LC-KCDSYCLQCQGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTA 1050



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 27/78 (34%), Positives = 35/78 (44%), Gaps = 11/78 (14%)

Query: 76  CLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKN--FCTKCKSGFYL-HLGKCLDNCPEG 132
           C+  CPSGYY  R      C KC + C TC  +    C+ C +   L H G C   C  G
Sbjct: 842 CVPDCPSGYYAER----GACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPG 897

Query: 133 --LEANNHTMECVSIVHC 148
             L+ N+    C +  HC
Sbjct: 898 HYLDDNHVCQPCNT--HC 913



 Score = 45.1 bits (105), Expect = 7e-05
 Identities = 30/112 (26%), Positives = 41/112 (36%), Gaps = 12/112 (10%)

Query: 36   NVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVC-LSSCPSGYYGTRYPDINK 94
            +V Q C   C +C     C SC+      L        G C   SC   YY       N 
Sbjct: 904  HVCQPCNTHCGSCDSQASCTSCRDPNKVLL-------FGECQYESCAPQYYLDF--STNT 954

Query: 95   CTKCKADCDTCFN--KNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVS 144
            C +C   C  C    K  C +C  G+ L  G C++ C      ++   +C S
Sbjct: 955  CKECDWSCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQDSGLCKCDS 1006



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 30/103 (29%), Positives = 41/103 (39%), Gaps = 10/103 (9%)

Query: 37  VSQGCQGGCATCSDY--NGCLSCK-PRLFFALERIGMKQI--GVCLSSCPSGYYGTRYPD 91
           V + C   C  C     + C  CK P     +E++    I  G CL+ C + +Y      
Sbjct: 651 VCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFY---LES 707

Query: 92  INKCTKCKADCDTCFNKN--FCTKCKSGFYLHLGKCLDNCPEG 132
              C  C   C  C  K+   CT C     L  G+CL  CP+G
Sbjct: 708 TGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDG 750



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 33/132 (25%), Positives = 46/132 (34%), Gaps = 19/132 (14%)

Query: 37  VSQGCQGGCATCSDYN--GCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINK 94
           + + C   C  C+  +   C  C P              G CLS CP GY+         
Sbjct: 710 ICEACHQSCFRCAGKSPHNCTDCGPSHVLL--------DGQCLSQCPDGYFHQE----GS 757

Query: 95  CTKCKADCDTCFN--KNFCTKCKSGFYLHLGKCLDNCPEG--LEANNHTMECVSIV-HCE 149
           CT+C   C  C    ++ C  C     L  G C  +C E   L    +  +C  +  HC 
Sbjct: 758 CTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCA 817

Query: 150 VSEWNPWSPCTK 161
               N  S C +
Sbjct: 818 ADLHNTGSICLR 829



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 24/88 (27%), Positives = 34/88 (38%), Gaps = 13/88 (14%)

Query: 41  CQGGCATCSDYN--GCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKC 98
           C   C TC       C SC   L        +   G C ++C  G+Y     D + C  C
Sbjct: 860 CHSSCRTCQGRGPFSCSSCDTNLV-------LSHTGTCSTTCFPGHY---LDDNHVCQPC 909

Query: 99  KADCDTCFNKNFCTKCKS-GFYLHLGKC 125
              C +C ++  CT C+     L  G+C
Sbjct: 910 NTHCGSCDSQASCTSCRDPNKVLLFGEC 937



 Score = 31.6 bits (70), Expect = 0.77
 Identities = 28/110 (25%), Positives = 41/110 (37%), Gaps = 23/110 (20%)

Query: 41  CQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKA 100
           C+G   TC +     SC P     +  + ++  G C   C S +    +PD   C++   
Sbjct: 384 CRGAQVTCYEP----SCPP---CPVGTLALEVKGQCCPDCTSVHC---HPDCLTCSQSPD 433

Query: 101 DCDTC------FNKNFCT-KCKSGFYLHLGKCL------DNCPEGLEANN 137
            CD C          +C   C  GFY     CL        C  GLE ++
Sbjct: 434 HCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSS 483



 Score = 29.6 bits (65), Expect = 2.9
 Identities = 26/120 (21%), Positives = 48/120 (40%), Gaps = 21/120 (17%)

Query: 30  QRRMHPNVSQGCQGGCATCSDYNGCLSCKPR----LFFALERIGMKQIGVCLSSC----- 80
           ++++H + ++     C+ CS  +G + C P+    L    + +     G C   C     
Sbjct: 98  EKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGK 157

Query: 81  PSGYYGTRYPD-----INKCTK--CKADCDTCFNKN----FCTKCKSGFYLHLGKCLDNC 129
           P  Y G  + D     +++C K  C+     CF       FC + ++   +  GKC   C
Sbjct: 158 PCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCNQDETVVRVP-GKCCPQC 216


>gi|20336246 proprotein convertase subtilisin/kexin type 5
           preproprotein [Homo sapiens]
          Length = 913

 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 29/94 (30%), Positives = 43/94 (45%), Gaps = 10/94 (10%)

Query: 41  CQGGCATCSDYNG--CLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKC 98
           C   C +C   +G  C+SCK   F        ++   C++ CP G Y       N C KC
Sbjct: 689 CAPNCESCFGSHGDQCMSCKYGYFLN------EETNSCVTHCPDGSYQDTKK--NLCRKC 740

Query: 99  KADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEG 132
             +C TC   + CT+C+ G  L   +C  +C +G
Sbjct: 741 SENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDG 774



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 23/62 (37%), Positives = 38/62 (61%), Gaps = 7/62 (11%)

Query: 75  VCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNK--NFCTKCKSGFYLH--LGKCLDNCP 130
           +C+SSCP G+Y   + D  +C KC  +C++CF    + C  CK G++L+     C+ +CP
Sbjct: 669 ICVSSCPPGHY---HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCP 725

Query: 131 EG 132
           +G
Sbjct: 726 DG 727



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 32/93 (34%), Positives = 40/93 (43%), Gaps = 14/93 (15%)

Query: 39  QGCQGGCATCSDY--NGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPD--INK 94
           Q C   CATC+    +GC++C    F         + G C+ SC   YY     +     
Sbjct: 783 QPCHRFCATCAGAGADGCINCTEGYFM--------EDGRCVQSCSISYYFDHSSENGYKS 834

Query: 95  CTKCKADCDTCFNKNF--CTKCKSGFYLHLGKC 125
           C KC   C TC    F  CT C SG+ L LG C
Sbjct: 835 CKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMC 867



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 26/96 (27%), Positives = 41/96 (42%), Gaps = 14/96 (14%)

Query: 36  NVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKC 95
           N+ + C   C TC++++ C  C+  L     R        C  SC  G    RY +   C
Sbjct: 735 NLCRKCSENCKTCTEFHNCTECRDGLSLQGSR--------CSVSCEDG----RYFNGQDC 782

Query: 96  TKCKADCDTC--FNKNFCTKCKSGFYLHLGKCLDNC 129
             C   C TC     + C  C  G+++  G+C+ +C
Sbjct: 783 QPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSC 818


>gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo
           sapiens]
          Length = 853

 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 45/183 (24%), Positives = 64/183 (34%), Gaps = 35/183 (19%)

Query: 39  QGCQGGCATCS-DYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINK--C 95
           Q C   C TC+     C SC    +   +         C+SSCP G     +P +    C
Sbjct: 174 QPCHSSCKTCNGSATLCTSCPKGAYLLAQ--------ACVSSCPQG----TWPSVRSGSC 221

Query: 96  TKCKADCDTCFNKNFCTKCKSG----FYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVS 151
             C   C  C   + C KC+       +LH G+C   CPEG  A +   E  S       
Sbjct: 222 ENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCS------- 274

Query: 152 EWNPWSPCTKKGKTCGFKRGTETRVREIIQ------HPSAKGNLCPPTNETRKCTVQRKK 205
             +P   C      C    G       + Q      H + KG +C    E  +  +  K 
Sbjct: 275 --SPCRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVKG-VCKHCPEMCQDCIHEKT 331

Query: 206 CQK 208
           C++
Sbjct: 332 CKE 334



 Score = 54.7 bits (130), Expect = 9e-08
 Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 6/70 (8%)

Query: 76  CLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNF--CTKCKSGFYLHLGK-CLDNCPEG 132
           C+  CP GYY     D N+C  C + C TC  ++   C  C+ G++  LGK CL  C EG
Sbjct: 493 CVKDCPEGYYADE--DSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF-QLGKECLLQCREG 549

Query: 133 LEANNHTMEC 142
             A+N T  C
Sbjct: 550 YYADNSTGRC 559



 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 33/109 (30%), Positives = 41/109 (37%), Gaps = 15/109 (13%)

Query: 37  VSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCT 96
           V + C   C  C     C  C P  F   +        +C  SCP G+Y     D   C 
Sbjct: 315 VCKHCPEMCQDCIHEKTCKECTPEFFLHDD--------MCHQSCPRGFYA----DSRHCV 362

Query: 97  KCKADCDTCFNKNF--CTKC-KSGFYLHLGKCLDNCPEGLEANNHTMEC 142
            C  DC  C       C  C +S + L+ G CL+ CP G      T EC
Sbjct: 363 PCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKEC 411



 Score = 52.0 bits (123), Expect = 6e-07
 Identities = 29/108 (26%), Positives = 44/108 (40%), Gaps = 14/108 (12%)

Query: 37  VSQGCQGGCATCS-DYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKC 95
           + + C   C TC  +   C SC        E   +   GVC  +CP  +   +      C
Sbjct: 269 ICERCSSPCRTCEGNATNCHSC--------EGGHVLHHGVCQENCPERHVAVK----GVC 316

Query: 96  TKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANN-HTMEC 142
             C   C  C ++  C +C   F+LH   C  +CP G  A++ H + C
Sbjct: 317 KHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPC 364



 Score = 51.6 bits (122), Expect = 7e-07
 Identities = 27/90 (30%), Positives = 41/90 (45%), Gaps = 13/90 (14%)

Query: 39  QGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKC 98
           + C   C +C D NGC  C+   F     +G    G C+  C  G+YG +  ++ +C  C
Sbjct: 76  KACDSNCGSC-DQNGCYWCEEGFFL----LG----GSCVRKCGPGFYGDQ--EMGECESC 124

Query: 99  KADCDTCFNKNF--CTKCKSGFYLHLGKCL 126
              C+TC       C+ C+ G  L  G C+
Sbjct: 125 HRACETCTGPGHDECSSCQEGLQLLRGMCV 154



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 33/96 (34%), Positives = 40/96 (41%), Gaps = 15/96 (15%)

Query: 39  QGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKC 98
           +GCQG   T      CLSC  R FF L     +  G C  SCP  YY  +      C +C
Sbjct: 567 KGCQGPRPT-----DCLSCD-RFFFLL-----RSKGECHRSCPDHYYVEQ--STQTCERC 613

Query: 99  KADCDTCFNKNF--CTKCKSGFYLHLGKCLDNCPEG 132
              CD C  K    C  C   ++L  G C  +C  G
Sbjct: 614 HPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVG 649



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 28/98 (28%), Positives = 42/98 (42%), Gaps = 12/98 (12%)

Query: 39  QGCQGGCATCSD--YNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDI-NKC 95
           + C   C TC+   ++ C SC+  L            G+C+ +  +   G  + DI  K 
Sbjct: 122 ESCHRACETCTGPGHDECSSCQEGLQLLR--------GMCVHATKTQEEGKFWNDILRKL 173

Query: 96  TKCKADCDTCFNK-NFCTKCKSGFYLHLGKCLDNCPEG 132
             C + C TC      CT C  G YL    C+ +CP+G
Sbjct: 174 QPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQG 211



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 27/89 (30%), Positives = 40/89 (44%), Gaps = 9/89 (10%)

Query: 45  CATCSDYNGCLSCK-PRLF---FALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKA 100
           C  C  +  CL C  P+       LE   +   G+CL  CP+G Y  +  +  +C  C  
Sbjct: 361 CVPC--HKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEK--ETKECRDCHK 416

Query: 101 DCDTCFNKNFCTKCKSGFYLH-LGKCLDN 128
            C TC +   CT C+ G  ++  G C+ N
Sbjct: 417 SCLTCSSSGTCTTCQKGLIMNPRGSCMAN 445



 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 21/69 (30%), Positives = 33/69 (47%), Gaps = 5/69 (7%)

Query: 76  CLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEA 135
           C  +CP       Y +  +C  C ++C +C ++N C  C+ GF+L  G C+  C  G   
Sbjct: 60  CYKTCPE----KTYSEAVECKACDSNCGSC-DQNGCYWCEEGFFLLGGSCVRKCGPGFYG 114

Query: 136 NNHTMECVS 144
           +    EC S
Sbjct: 115 DQEMGECES 123



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 37/125 (29%), Positives = 48/125 (38%), Gaps = 28/125 (22%)

Query: 32  RMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPD 91
           R HP   Q C+G  A       CLSC     ++   +G    G+C S C  G Y     +
Sbjct: 612 RCHPTCDQ-CKGKGAL-----NCLSC----VWSYHLMG----GICTSDCLVGEYRVGEGE 657

Query: 92  INKCTKCKADCDTCFN---KNFCTKCKSGFYLHL--GKCLDNC--------PEGLEANNH 138
              C KC   C  C     KN CT C +   LH+    CL  C         E  +  + 
Sbjct: 658 KFNCEKCHESCMECKGPGAKN-CTLCPANLVLHMDDSHCLHCCNTSDPPSAQECCDCQDT 716

Query: 139 TMECV 143
           T EC+
Sbjct: 717 TDECI 721


>gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo
           sapiens]
          Length = 853

 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 45/183 (24%), Positives = 64/183 (34%), Gaps = 35/183 (19%)

Query: 39  QGCQGGCATCS-DYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINK--C 95
           Q C   C TC+     C SC    +   +         C+SSCP G     +P +    C
Sbjct: 174 QPCHSSCKTCNGSATLCTSCPKGAYLLAQ--------ACVSSCPQG----TWPSVRSGSC 221

Query: 96  TKCKADCDTCFNKNFCTKCKSG----FYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVS 151
             C   C  C   + C KC+       +LH G+C   CPEG  A +   E  S       
Sbjct: 222 ENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCS------- 274

Query: 152 EWNPWSPCTKKGKTCGFKRGTETRVREIIQ------HPSAKGNLCPPTNETRKCTVQRKK 205
             +P   C      C    G       + Q      H + KG +C    E  +  +  K 
Sbjct: 275 --SPCRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVKG-VCKHCPEMCQDCIHEKT 331

Query: 206 CQK 208
           C++
Sbjct: 332 CKE 334



 Score = 54.7 bits (130), Expect = 9e-08
 Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 6/70 (8%)

Query: 76  CLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNF--CTKCKSGFYLHLGK-CLDNCPEG 132
           C+  CP GYY     D N+C  C + C TC  ++   C  C+ G++  LGK CL  C EG
Sbjct: 493 CVKDCPEGYYADE--DSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF-QLGKECLLQCREG 549

Query: 133 LEANNHTMEC 142
             A+N T  C
Sbjct: 550 YYADNSTGRC 559



 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 33/109 (30%), Positives = 41/109 (37%), Gaps = 15/109 (13%)

Query: 37  VSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCT 96
           V + C   C  C     C  C P  F   +        +C  SCP G+Y     D   C 
Sbjct: 315 VCKHCPEMCQDCIHEKTCKECTPEFFLHDD--------MCHQSCPRGFYA----DSRHCV 362

Query: 97  KCKADCDTCFNKNF--CTKC-KSGFYLHLGKCLDNCPEGLEANNHTMEC 142
            C  DC  C       C  C +S + L+ G CL+ CP G      T EC
Sbjct: 363 PCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKEC 411



 Score = 52.0 bits (123), Expect = 6e-07
 Identities = 29/108 (26%), Positives = 44/108 (40%), Gaps = 14/108 (12%)

Query: 37  VSQGCQGGCATCS-DYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKC 95
           + + C   C TC  +   C SC        E   +   GVC  +CP  +   +      C
Sbjct: 269 ICERCSSPCRTCEGNATNCHSC--------EGGHVLHHGVCQENCPERHVAVK----GVC 316

Query: 96  TKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANN-HTMEC 142
             C   C  C ++  C +C   F+LH   C  +CP G  A++ H + C
Sbjct: 317 KHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPC 364



 Score = 51.6 bits (122), Expect = 7e-07
 Identities = 27/90 (30%), Positives = 41/90 (45%), Gaps = 13/90 (14%)

Query: 39  QGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKC 98
           + C   C +C D NGC  C+   F     +G    G C+  C  G+YG +  ++ +C  C
Sbjct: 76  KACDSNCGSC-DQNGCYWCEEGFFL----LG----GSCVRKCGPGFYGDQ--EMGECESC 124

Query: 99  KADCDTCFNKNF--CTKCKSGFYLHLGKCL 126
              C+TC       C+ C+ G  L  G C+
Sbjct: 125 HRACETCTGPGHDECSSCQEGLQLLRGMCV 154



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 33/96 (34%), Positives = 40/96 (41%), Gaps = 15/96 (15%)

Query: 39  QGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKC 98
           +GCQG   T      CLSC  R FF L     +  G C  SCP  YY  +      C +C
Sbjct: 567 KGCQGPRPT-----DCLSCD-RFFFLL-----RSKGECHRSCPDHYYVEQ--STQTCERC 613

Query: 99  KADCDTCFNKNF--CTKCKSGFYLHLGKCLDNCPEG 132
              CD C  K    C  C   ++L  G C  +C  G
Sbjct: 614 HPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVG 649



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 28/98 (28%), Positives = 42/98 (42%), Gaps = 12/98 (12%)

Query: 39  QGCQGGCATCSD--YNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDI-NKC 95
           + C   C TC+   ++ C SC+  L            G+C+ +  +   G  + DI  K 
Sbjct: 122 ESCHRACETCTGPGHDECSSCQEGLQLLR--------GMCVHATKTQEEGKFWNDILRKL 173

Query: 96  TKCKADCDTCFNK-NFCTKCKSGFYLHLGKCLDNCPEG 132
             C + C TC      CT C  G YL    C+ +CP+G
Sbjct: 174 QPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQG 211



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 27/89 (30%), Positives = 40/89 (44%), Gaps = 9/89 (10%)

Query: 45  CATCSDYNGCLSCK-PRLF---FALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKA 100
           C  C  +  CL C  P+       LE   +   G+CL  CP+G Y  +  +  +C  C  
Sbjct: 361 CVPC--HKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEK--ETKECRDCHK 416

Query: 101 DCDTCFNKNFCTKCKSGFYLH-LGKCLDN 128
            C TC +   CT C+ G  ++  G C+ N
Sbjct: 417 SCLTCSSSGTCTTCQKGLIMNPRGSCMAN 445



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 21/69 (30%), Positives = 32/69 (46%), Gaps = 5/69 (7%)

Query: 76  CLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEA 135
           C  +CP   Y        +C  C ++C +C ++N C  C+ GF+L  G C+  C  G   
Sbjct: 60  CYKTCPEKTYSEEV----ECKACDSNCGSC-DQNGCYWCEEGFFLLGGSCVRKCGPGFYG 114

Query: 136 NNHTMECVS 144
           +    EC S
Sbjct: 115 DQEMGECES 123



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 37/125 (29%), Positives = 48/125 (38%), Gaps = 28/125 (22%)

Query: 32  RMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPD 91
           R HP   Q C+G  A       CLSC     ++   +G    G+C S C  G Y     +
Sbjct: 612 RCHPTCDQ-CKGKGAL-----NCLSC----VWSYHLMG----GICTSDCLVGEYRVGEGE 657

Query: 92  INKCTKCKADCDTCFN---KNFCTKCKSGFYLHL--GKCLDNC--------PEGLEANNH 138
              C KC   C  C     KN CT C +   LH+    CL  C         E  +  + 
Sbjct: 658 KFNCEKCHESCMECKGPGAKN-CTLCPANLVLHMDDSHCLHCCNTSDPPSAQECCDCQDT 716

Query: 139 TMECV 143
           T EC+
Sbjct: 717 TDECI 721


>gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]
          Length = 807

 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 12/109 (11%)

Query: 126 LDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSA 185
           L +C E LE     M     + CE++EW+ WS C    K+CG  +G   R R I   P  
Sbjct: 647 LGDCNEDLEQVEKCMLPECPIDCELTEWSQWSEC---NKSCG--KGHVIRTRMIQMEPQF 701

Query: 186 KGNLCPPTNETRKCTVQRKKCQKGE-----RGKKGRERKRKKPNKGESK 229
            G  CP T + +KC +  +KC +       R ++ RE +R +  K ES+
Sbjct: 702 GGAPCPETVQRKKCRI--RKCLRNPSIQKLRWREARESRRSEQLKEESE 748



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 25/58 (43%), Positives = 33/58 (56%), Gaps = 7/58 (12%)

Query: 148 CEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCP-PTNETRKCTVQRK 204
           C +SEW  WSPC+    +CG   G  +R R + Q P   G++C  PT ET KCTV  +
Sbjct: 502 CTMSEWITWSPCS---ISCGM--GMRSRERYVKQFPE-DGSVCTLPTEETEKCTVNEE 553


>gi|239755070 PREDICTED: similar to proprotein convertase
           subtilisin/kexin type 5 [Homo sapiens]
          Length = 853

 Score = 54.7 bits (130), Expect = 9e-08
 Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 6/70 (8%)

Query: 76  CLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNF--CTKCKSGFYLHLGK-CLDNCPEG 132
           C+  CP GYY     D N+C  C + C TC  ++   C  C+ G++  LGK CL  C EG
Sbjct: 493 CVKDCPEGYYADE--DSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF-QLGKECLLQCREG 549

Query: 133 LEANNHTMEC 142
             A+N T  C
Sbjct: 550 YYADNSTGRC 559



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 36/123 (29%), Positives = 47/123 (38%), Gaps = 20/123 (16%)

Query: 39  QGCQGGCATCS-DYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINK--C 95
           Q C   C TC+     C SC    +   +         C+SSCP G     +P +    C
Sbjct: 174 QPCHSSCKTCNGSATLCTSCPKGAYLLAQ--------ACVSSCPQG----TWPSVRSGSC 221

Query: 96  TKCKADCDTCFNKNFCTKCKSG----FYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVS 151
             C   C  C   + C KC+       +LH G+C   CPEG  A +   E  S   C   
Sbjct: 222 ENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCS-SPCRTC 280

Query: 152 EWN 154
           E N
Sbjct: 281 EGN 283



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 33/109 (30%), Positives = 42/109 (38%), Gaps = 15/109 (13%)

Query: 37  VSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCT 96
           V + C   C  C     C  C P  F   +        +C  SCP G+Y     D + C 
Sbjct: 315 VCKHCPEMCQDCIHEKTCKECMPEFFLHDD--------MCHQSCPRGFYA----DSHHCV 362

Query: 97  KCKADCDTCFNKNF--CTKC-KSGFYLHLGKCLDNCPEGLEANNHTMEC 142
            C  DC  C       C  C +S + L+ G CL+ CP G      T EC
Sbjct: 363 PCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKQTKEC 411



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 28/103 (27%), Positives = 41/103 (39%), Gaps = 13/103 (12%)

Query: 37  VSQGCQGGCATCS-DYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKC 95
           + + C   C TC  +   C SC        E   +   GVC  +CP  +          C
Sbjct: 269 ICERCSSPCRTCEGNATNCHSC--------EGGHVLHHGVCQENCPERHVAVE----GVC 316

Query: 96  TKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNH 138
             C   C  C ++  C +C   F+LH   C  +CP G  A++H
Sbjct: 317 KHCPEMCQDCIHEKTCKECMPEFFLHDDMCHQSCPRGFYADSH 359



 Score = 52.0 bits (123), Expect = 6e-07
 Identities = 27/90 (30%), Positives = 42/90 (46%), Gaps = 13/90 (14%)

Query: 39  QGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKC 98
           + C   C++C D NGC  C+   F     +G    G C+  C  G+YG +  ++ +C  C
Sbjct: 76  KACDSNCSSC-DQNGCYWCEEGFFL----LG----GSCVRKCGPGFYGDQ--EMGECESC 124

Query: 99  KADCDTCFNKNF--CTKCKSGFYLHLGKCL 126
              C+TC       C+ C+ G  L  G C+
Sbjct: 125 HRACETCTGPGHDECSSCQEGLQLLRGMCV 154



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 33/96 (34%), Positives = 40/96 (41%), Gaps = 15/96 (15%)

Query: 39  QGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKC 98
           +GCQG   T      CLSC  R FF L     +  G C  SCP  YY  +      C +C
Sbjct: 567 KGCQGPRPT-----DCLSCD-RFFFLL-----RSKGECHRSCPDHYYVEQ--STQTCERC 613

Query: 99  KADCDTCFNKNF--CTKCKSGFYLHLGKCLDNCPEG 132
              CD C  K    C  C   ++L  G C  +C  G
Sbjct: 614 HPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVG 649



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 28/98 (28%), Positives = 42/98 (42%), Gaps = 12/98 (12%)

Query: 39  QGCQGGCATCSD--YNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDI-NKC 95
           + C   C TC+   ++ C SC+  L            G+C+ +  +   G  + DI  K 
Sbjct: 122 ESCHRACETCTGPGHDECSSCQEGLQLLR--------GMCVHATKTQEEGKFWNDILRKL 173

Query: 96  TKCKADCDTCFNK-NFCTKCKSGFYLHLGKCLDNCPEG 132
             C + C TC      CT C  G YL    C+ +CP+G
Sbjct: 174 QPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQG 211



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 27/89 (30%), Positives = 39/89 (43%), Gaps = 9/89 (10%)

Query: 45  CATCSDYNGCLSCK-PRLF---FALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKA 100
           C  C  +  CL C  P+       LE   +   G+CL  CP+G Y  +     +C  C  
Sbjct: 361 CVPC--HKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEK--QTKECRDCHK 416

Query: 101 DCDTCFNKNFCTKCKSGFYLH-LGKCLDN 128
            C TC +   CT C+ G  ++  G C+ N
Sbjct: 417 SCLTCSSSGTCTTCQKGLIMNPRGSCMAN 445



 Score = 45.1 bits (105), Expect = 7e-05
 Identities = 21/69 (30%), Positives = 33/69 (47%), Gaps = 5/69 (7%)

Query: 76  CLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEA 135
           C  +CP       Y +  +C  C ++C +C ++N C  C+ GF+L  G C+  C  G   
Sbjct: 60  CYKTCPE----KTYSEAVECKACDSNCSSC-DQNGCYWCEEGFFLLGGSCVRKCGPGFYG 114

Query: 136 NNHTMECVS 144
           +    EC S
Sbjct: 115 DQEMGECES 123



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 37/125 (29%), Positives = 49/125 (39%), Gaps = 28/125 (22%)

Query: 32  RMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPD 91
           R HP   Q C+G  A       CLSC     ++   +G    G+C S C  G Y     +
Sbjct: 612 RCHPTCDQ-CKGKGAL-----NCLSC----VWSYHLMG----GICTSDCLVGEYRVGEGE 657

Query: 92  INKCTKCKADCDTCFN---KNFCTKCKSGFYLHLGK--CLDNC--------PEGLEANNH 138
              C KC   C  C     KN CT C +   LH+ +  CL  C         E  +  + 
Sbjct: 658 KFNCEKCHESCMECKGPGAKN-CTLCPANLVLHMDESHCLHCCNTSDPPSAQECCDCQDT 716

Query: 139 TMECV 143
           T EC+
Sbjct: 717 TDECI 721


>gi|150170672 thrombospondin, type I, domain containing 7A [Homo
           sapiens]
          Length = 1657

 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 24/61 (39%), Positives = 27/61 (44%)

Query: 142 CVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTV 201
           CV    C+VSEW+ WSPC+K         GT  R R I Q P      CP   E   C  
Sbjct: 355 CVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLS 414

Query: 202 Q 202
           Q
Sbjct: 415 Q 415



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 37/133 (27%), Positives = 60/133 (45%), Gaps = 24/133 (18%)

Query: 148 CEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQ 207
           C VSE++ WS C+   KTCG   G + R R ++  P   G+ CP   E + C  Q   C+
Sbjct: 195 CIVSEFSAWSECS---KTCG--SGLQHRTRHVVAPPQFGGSGCPNLTEFQVC--QSSPCE 247

Query: 208 KGE----------------RGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQR-EN 250
             E                  ++ R+ +R+  NK   K+     K  E+ + I ++R  N
Sbjct: 248 AEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRN 307

Query: 251 KQQQKKRKVQDKQ 263
           +Q +++ K  D Q
Sbjct: 308 RQNRQENKYWDIQ 320



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 29/88 (32%), Positives = 46/88 (52%), Gaps = 14/88 (15%)

Query: 132  GLEAN-----NHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAK 186
            GLE N     +  +EC   V+C++S+W+PWS C+   +TCG   G   R R + Q     
Sbjct: 1268 GLEKNWQMNTSCMVECP--VNCQLSDWSPWSECS---QTCGL-TGKMIRRRTVTQPFQGD 1321

Query: 187  GNLCPP-TNETRKCTVQRKKCQKGERGK 213
            G  CP   ++++ C V  K C + + G+
Sbjct: 1322 GRPCPSLMDQSKPCPV--KPCYRWQYGQ 1347



 Score = 38.1 bits (87), Expect = 0.008
 Identities = 18/74 (24%), Positives = 31/74 (41%), Gaps = 4/74 (5%)

Query: 130  PEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNL 189
            PE +   +   +      C +SEW PW+ C        F++    R  + I+ P+ +G  
Sbjct: 1148 PEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQ----RSADPIRQPADEGRS 1203

Query: 190  CPPTNETRKCTVQR 203
            CP   E   C + +
Sbjct: 1204 CPNAVEKEPCNLNK 1217



 Score = 35.8 bits (81), Expect = 0.041
 Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 26/116 (22%)

Query: 91   DINKCTK-CKADCDTCFNKNF----CTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSI 145
            DI +C +  +     C+++N      ++C S  Y+    C+  CP               
Sbjct: 990  DIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEA-CIIPCPSD------------- 1035

Query: 146  VHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTV 201
              C++SEW+ WS C+   K+CG   G + R + + + P   G  CP  +   +  V
Sbjct: 1036 --CKLSEWSNWSRCS---KSCG--SGVKVRSKWLREKPYNGGRPCPKLDHVNQAQV 1084



 Score = 34.3 bits (77), Expect = 0.12
 Identities = 19/56 (33%), Positives = 25/56 (44%), Gaps = 4/56 (7%)

Query: 148 CEVSEWNPWSPCTKKG-KTCGFKRGTETRVREIIQHPSAKGNL---CPPTNETRKC 199
           CEVS W+ W PCT +       K+G + R R I   P+    +   CP   E   C
Sbjct: 513 CEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPC 568



 Score = 33.1 bits (74), Expect = 0.27
 Identities = 20/58 (34%), Positives = 29/58 (50%), Gaps = 9/58 (15%)

Query: 148 CEVSEWNPWSPC--TKKGKTCGFKRGTETRVREIIQHPSAKGNL-CPPTN---ETRKC 199
           C +S W+ WS C  T  GKT     G + R R I+ +   +G + CP ++   E R C
Sbjct: 635 CVLSTWSTWSSCSHTCSGKT---TEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSC 689



 Score = 30.0 bits (66), Expect = 2.2
 Identities = 18/56 (32%), Positives = 26/56 (46%), Gaps = 5/56 (8%)

Query: 148  CEVSEWNPWSPC---TKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTN-ETRKC 199
            C + +W+ WS C      G+  GF  G + R R +I       +LCP    ET+ C
Sbjct: 1415 CYLKDWSSWSLCQLTCVNGEDLGF-GGIQVRSRPVIIQELENQHLCPEQMLETKSC 1469


>gi|31657140 insulin receptor-related receptor precursor [Homo
           sapiens]
          Length = 1297

 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 30/102 (29%), Positives = 44/102 (43%), Gaps = 17/102 (16%)

Query: 41  CQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKA 100
           C GGC+   D   C++C+  L+F          G CL +CP G Y  +Y      T    
Sbjct: 233 CLGGCSQPEDPRACVACR-HLYFQ---------GACLWACPPGTY--QYESWRCVT---- 276

Query: 101 DCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMEC 142
             + C + +      S F +H G CL  CP G   N+ ++ C
Sbjct: 277 -AERCASLHSVPGRASTFGIHQGSCLAQCPSGFTRNSSSIFC 317


>gi|111125011 WNT inhibitory factor 1 precursor [Homo sapiens]
          Length = 379

 Score = 45.1 bits (105), Expect = 7e-05
 Identities = 48/187 (25%), Positives = 71/187 (37%), Gaps = 54/187 (28%)

Query: 74  GVCLSSCPSGYYGTRYPDINKCTKCKADCD-TCFNKNFCTKCKSGFYLHLGKCLDNCPEG 132
           G C+  CP G+YG            KA+C  TCFN   C         + GKC+  CP G
Sbjct: 228 GFCI--CPPGFYGVNCD--------KANCSTTCFNGGTC--------FYPGKCI--CPPG 267

Query: 133 LEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPP 192
           LE             CE+S+     PC   GK  G    ++ +  +  Q       +C P
Sbjct: 268 LEGE----------QCEISKCP--QPCRNGGKCIG---KSKCKCSKGYQGDLCSKPVCEP 312

Query: 193 -------TNETRKCTVQRKKCQKGERGKKGRERKRK------KPNKGESKEAIPDSKSLE 239
                   +E  KC     +CQ+G  G+   +R         +P   + ++  P  K  E
Sbjct: 313 GCGAHGTCHEPNKC-----QCQEGWHGRHCNKRYEASLIHALRPAGAQLRQHTPSLKKAE 367

Query: 240 SSKEIPE 246
             ++ PE
Sbjct: 368 ERRDPPE 374


>gi|122937257 thrombospondin, type I, domain containing 7B [Homo
           sapiens]
          Length = 1577

 Score = 45.1 bits (105), Expect = 7e-05
 Identities = 21/70 (30%), Positives = 32/70 (45%)

Query: 142 CVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTV 201
           C+    CE S+W+ WSPC+K  ++     G  +R R +       G  CP   E   C V
Sbjct: 300 CIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIV 359

Query: 202 QRKKCQKGER 211
           + +  Q+  R
Sbjct: 360 EGELLQQCPR 369



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 38/127 (29%), Positives = 54/127 (42%), Gaps = 15/127 (11%)

Query: 148 CEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQ 207
           C VSE+ PWS C+   K CG K   + R R +I  P   G  CP   E+R C      C 
Sbjct: 149 CVVSEFLPWSNCS---KGCGKK--LQHRTRAVIAPPLFGGLQCPNLTESRACDAP-ISCP 202

Query: 208 KGERG-----KKGRERKRKKPNKGESKEAIPDSKS-LESSKEIPEQRENKQQQKKRKVQD 261
            GE       K G   K + P+    KE  P  ++ L+ + +  E+   K Q  K     
Sbjct: 203 LGEEEYTFSLKVGPWSKCRLPH---LKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHS 259

Query: 262 KQKSVSV 268
           K  ++ +
Sbjct: 260 KSWAIEI 266



 Score = 37.7 bits (86), Expect = 0.011
 Identities = 24/76 (31%), Positives = 33/76 (43%), Gaps = 8/76 (10%)

Query: 129 CPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKR--GTETRVREIIQHPSAK 186
           CP        + E    + C +SEW  WS C+   ++C  K   G +TR R I+      
Sbjct: 552 CPVPPPPERKSCEIPCRMDCVLSEWTEWSSCS---QSCSNKNSDGKQTRSRTILALAGEG 608

Query: 187 GNLCPPT---NETRKC 199
           G  CPP+    E R C
Sbjct: 609 GKPCPPSQALQEHRLC 624



 Score = 37.4 bits (85), Expect = 0.014
 Identities = 24/67 (35%), Positives = 35/67 (52%), Gaps = 7/67 (10%)

Query: 140  MECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKC 199
            +ECV  V+C++S W  W+ C+   +TCG   G  +R R II     +G  C PT  T++ 
Sbjct: 1213 VECV--VNCQLSGWTAWTECS---QTCG-HGGRMSRTRFIIMPTQGEGRPC-PTELTQEK 1265

Query: 200  TVQRKKC 206
            T     C
Sbjct: 1266 TCPVTPC 1272



 Score = 31.2 bits (69), Expect = 1.0
 Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 8/68 (11%)

Query: 148 CEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPT-------NETRKCT 200
           C V+ ++ W+PC +  +  G     ++R R IIQ  +  G  CP T        +   C 
Sbjct: 707 CIVTAFSEWTPCPRMCQA-GNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCP 765

Query: 201 VQRKKCQK 208
           V R K QK
Sbjct: 766 VYRWKPQK 773



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 20/78 (25%), Positives = 31/78 (39%), Gaps = 21/78 (26%)

Query: 114  CKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTE 173
            C S  Y+   KC+  CP                 C++S+W+ W  C+    +CG   G  
Sbjct: 952  CSSSGYIQ-EKCVIPCP---------------FDCKLSDWSSWGSCS---SSCGI--GVR 990

Query: 174  TRVREIIQHPSAKGNLCP 191
             R + + + P   G  CP
Sbjct: 991  IRSKWLKEKPYNGGRPCP 1008



 Score = 29.6 bits (65), Expect = 2.9
 Identities = 15/53 (28%), Positives = 22/53 (41%), Gaps = 1/53 (1%)

Query: 148 CEVSEWNPWSPCTKKG-KTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKC 199
           C VS W+ W  C  +       K+G  TR R ++   +     CP   E+  C
Sbjct: 454 CIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPC 506



 Score = 29.3 bits (64), Expect = 3.8
 Identities = 20/59 (33%), Positives = 26/59 (44%), Gaps = 9/59 (15%)

Query: 148  CEVSEWNPWSPCTKKGKTCGFKR-----GTETRVREIIQHPSAKGNLCP-PTNETRKCT 200
            C ++EW+ WS C     TC   R     G ++R R  I       + CP    ETR CT
Sbjct: 1342 CHLTEWSEWSTCE---LTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLETRPCT 1397


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
           sapiens]
          Length = 1367

 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 35/142 (24%), Positives = 58/142 (40%), Gaps = 44/142 (30%)

Query: 41  CQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKA 100
           C G C+   +   C++C+   ++A         GVC+ +CP   Y             + 
Sbjct: 235 CLGSCSAPDNDTACVACR-HYYYA---------GVCVPACPPNTY-------------RF 271

Query: 101 DCDTCFNKNFCTKCKS-------GFYLHLGKCLDNCPEGLEAN-NHTMECVSIVHCEVSE 152
           +   C +++FC    S       GF +H G+C+  CP G   N + +M C+    CE   
Sbjct: 272 EGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIP---CE--- 325

Query: 153 WNPWSPCTKKGKTCGFKRGTET 174
                PC    K C  ++ T+T
Sbjct: 326 ----GPCP---KVCEEEKKTKT 340


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 27/107 (25%), Positives = 57/107 (53%), Gaps = 4/107 (3%)

Query: 158 PCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRE 217
           PCT++      +R  E R RE  +    K        + +K   +R++ ++ ER +K RE
Sbjct: 28  PCTQRES----ERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKERE 83

Query: 218 RKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQK 264
           ++RK+  + E ++   + K  E  +    +R+ K+++K+R+ ++KQ+
Sbjct: 84  KQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQR 130



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 23/64 (35%), Positives = 40/64 (62%), Gaps = 1/64 (1%)

Query: 202 QRKKCQKGERGKKGRERKRKKPNKGE-SKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQ 260
           +R+K +K E+ +  RERKRKK  K E  K+   + K  +  +E  E+RE K+++KK + +
Sbjct: 142 KRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRK 201

Query: 261 DKQK 264
            K++
Sbjct: 202 KKER 205



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 19/68 (27%), Positives = 44/68 (64%), Gaps = 4/68 (5%)

Query: 197 RKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKK 256
           RK   ++++ ++ ERGK+ R+RK++K  + E K      ++ +  K+  E++E ++++K+
Sbjct: 139 RKKKRRKERKREKERGKRERKRKKRKKEEREKKR----ERNRKERKKERERKERRERKKE 194

Query: 257 RKVQDKQK 264
           RK + ++K
Sbjct: 195 RKKERRKK 202



 Score = 37.4 bits (85), Expect = 0.014
 Identities = 22/64 (34%), Positives = 39/64 (60%), Gaps = 3/64 (4%)

Query: 202 QRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQ-QQKKRKVQ 260
           +R+K +K  R K+ R+RK++K  +   +    + K  +  KE   +RENKQ +++KRK +
Sbjct: 81  EREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKE--RERENKQRRERKRKKR 138

Query: 261 DKQK 264
            K+K
Sbjct: 139 RKKK 142



 Score = 37.0 bits (84), Expect = 0.018
 Identities = 22/70 (31%), Positives = 41/70 (58%), Gaps = 12/70 (17%)

Query: 195 ETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQ 254
           E RK   ++KK ++ +RG+  RERK+KK  K   +E          +K+  E++  K+++
Sbjct: 93  ERRKRKKEKKKRERKQRGR--RERKKKKERKERERE----------NKQRRERKRKKRRK 140

Query: 255 KKRKVQDKQK 264
           KKR+ + K++
Sbjct: 141 KKRRKERKRE 150



 Score = 36.6 bits (83), Expect = 0.024
 Identities = 16/63 (25%), Positives = 40/63 (63%)

Query: 202 QRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQD 261
           QRK+ ++ ER K+ +E+K+++  +   +E     +  E  +E  ++RE K++++++K + 
Sbjct: 85  QRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRR 144

Query: 262 KQK 264
           K++
Sbjct: 145 KER 147



 Score = 35.4 bits (80), Expect = 0.053
 Identities = 21/71 (29%), Positives = 42/71 (59%), Gaps = 2/71 (2%)

Query: 196 TRKCTVQRKKCQKGERGKKGRERKRKKPNKGE-SKEAIPDSKSLESSKEIPEQR-ENKQQ 253
           ++ CT +  + +K  R ++ R+R+R+K  K E  K+     K  E  KE   +R E ++Q
Sbjct: 26  SKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQ 85

Query: 254 QKKRKVQDKQK 264
           +K+R+ ++++K
Sbjct: 86  RKERREKERRK 96



 Score = 34.7 bits (78), Expect = 0.091
 Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 1/66 (1%)

Query: 199 CTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRK 258
           C+   K C + E  +K   R+R+K  +   KE   +    E  K    +R  K++++KRK
Sbjct: 22  CSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRER-GKERERKRK 80

Query: 259 VQDKQK 264
            ++KQ+
Sbjct: 81  EREKQR 86



 Score = 33.5 bits (75), Expect = 0.20
 Identities = 18/65 (27%), Positives = 37/65 (56%), Gaps = 2/65 (3%)

Query: 202 QRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQ--QKKRKV 259
           +R++  K  R +K ++R++KK  K   +E     +  +  K   E+RE K++  +K+RK 
Sbjct: 122 ERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKK 181

Query: 260 QDKQK 264
           + ++K
Sbjct: 182 ERERK 186



 Score = 33.1 bits (74), Expect = 0.27
 Identities = 19/66 (28%), Positives = 38/66 (57%), Gaps = 3/66 (4%)

Query: 202 QRKKCQKGER---GKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRK 258
           ++KK ++ ER    K+ RERKRKK  K + ++     K     +   ++R+ ++++KKR+
Sbjct: 114 RKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRE 173

Query: 259 VQDKQK 264
              K++
Sbjct: 174 RNRKER 179



 Score = 32.3 bits (72), Expect = 0.45
 Identities = 24/98 (24%), Positives = 48/98 (48%), Gaps = 2/98 (2%)

Query: 169 KRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERG-KKGRERK-RKKPNKG 226
           +RG E   +   +    K        + +K   +R++ Q+G R  KK +ERK R++ NK 
Sbjct: 70  ERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQ 129

Query: 227 ESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQK 264
             +      +  +  KE   ++E  ++++KRK + K++
Sbjct: 130 RRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEE 167


>gi|119395738 insulin receptor isoform Short precursor [Homo
           sapiens]
          Length = 1370

 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 30/113 (26%), Positives = 45/113 (39%), Gaps = 34/113 (30%)

Query: 41  CQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKA 100
           C G C+   D   C++C+    F L+       G C+ +CP  YY   + D         
Sbjct: 239 CLGNCSQPDDPTKCVACRN---FYLD-------GRCVETCPPPYY--HFQDWR------- 279

Query: 101 DCDTCFNKNFCT----KCKSG-------FYLHLGKCLDNCPEGLEANNHTMEC 142
               C N +FC     KCK+        + +H  KC+  CP G   N+  + C
Sbjct: 280 ----CVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLC 328


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 30/113 (26%), Positives = 45/113 (39%), Gaps = 34/113 (30%)

Query: 41  CQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKA 100
           C G C+   D   C++C+    F L+       G C+ +CP  YY   + D         
Sbjct: 239 CLGNCSQPDDPTKCVACRN---FYLD-------GRCVETCPPPYY--HFQDWR------- 279

Query: 101 DCDTCFNKNFCT----KCKSG-------FYLHLGKCLDNCPEGLEANNHTMEC 142
               C N +FC     KCK+        + +H  KC+  CP G   N+  + C
Sbjct: 280 ----CVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLC 328


>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 123

 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 24/70 (34%), Positives = 43/70 (61%), Gaps = 2/70 (2%)

Query: 195 ETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQ 254
           E +K T + +K ++ E  +K R+RKRKK  K E +E   + +  E  KE  E+ E ++++
Sbjct: 41  EKKKKTKETEKRKEKEEEEKKRKRKRKK--KKEEEEREEEEEEEEEEKEEEEKEEGRRRK 98

Query: 255 KKRKVQDKQK 264
           KK+K + K++
Sbjct: 99  KKKKRRRKEE 108



 Score = 37.7 bits (86), Expect = 0.011
 Identities = 16/67 (23%), Positives = 43/67 (64%)

Query: 198 KCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKR 257
           K T +RK+ ++ E+ +K + +K+K+  + E +E   + +  E  KE   +R+ K++++++
Sbjct: 47  KETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRK 106

Query: 258 KVQDKQK 264
           + ++++K
Sbjct: 107 EEEEEKK 113



 Score = 30.8 bits (68), Expect = 1.3
 Identities = 11/51 (21%), Positives = 30/51 (58%)

Query: 214 KGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQK 264
           K +++K+K+  + E  E   + +  E  ++   + + K+++KK+K ++ +K
Sbjct: 1   KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEK 51


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 42/168 (25%), Positives = 62/168 (36%), Gaps = 32/168 (19%)

Query: 47   TCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYY--GTRYPDINKCTKCKADCDT 104
            +C D N C    P        IG    G     C  GY   G +  D+N+C +     + 
Sbjct: 5189 SCQDINECQESSPCHQRCFNAIGSFHCG-----CEPGYQLKGRKCMDVNECRQ-----NV 5238

Query: 105  CFNKNFCTKCKSGFYLHLGKCLDNCPEGL-EANNHTMECVSIVHCE----VSEWNPWSPC 159
            C     C   + G+     KC+D CP G+ +A N T  C+ I  C+       +N     
Sbjct: 5239 CRPDQHCKNTRGGY-----KCIDLCPNGMTKAENGT--CIDIDECKDGTHQCRYNQICEN 5291

Query: 160  TKKGKTCGFKRGTETR--------VREIIQHPSAKGNLCPPTNETRKC 199
            T+    C   RG  ++        + E  Q P    + C  T  + KC
Sbjct: 5292 TRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKC 5339



 Score = 35.0 bits (79), Expect = 0.070
 Identities = 38/182 (20%), Positives = 65/182 (35%), Gaps = 39/182 (21%)

Query: 32   RMHPNVSQG-----CQGGCAT------CSDYNGCLSCKPRLFFALERIGMKQIGVCLSSC 80
            ++H ++S+G     C  G         C+D + C +  P             +G    SC
Sbjct: 5078 KIHASISKGDRSNQCPSGFTLDSVGPFCADEDECAAGNP-----CSHSCHNAMGTYYCSC 5132

Query: 81   PSGYY----GTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEAN 136
            P G      G    DI++C   +    TC     C      +     +C+  C  G    
Sbjct: 5133 PKGLTIAADGRTCQDIDECALGR---HTCHAGQDCDNTIGSY-----RCVVRCGSGFRRT 5184

Query: 137  NHTMECVSIVHCEVSEWNPWSPCTKK------GKTCGFKRGTETRVREIIQHPSAKGNLC 190
            +  + C  I  C+ S     SPC ++         CG + G + + R+ +     + N+C
Sbjct: 5185 SDGLSCQDINECQES-----SPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVC 5239

Query: 191  PP 192
             P
Sbjct: 5240 RP 5241



 Score = 33.5 bits (75), Expect = 0.20
 Identities = 20/61 (32%), Positives = 27/61 (44%), Gaps = 5/61 (8%)

Query: 146  VHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKK 205
            VH   S W PW  C+   ++CG  +GT+TR R     P A G       ET+      + 
Sbjct: 4642 VHGAWSAWQPWGTCS---ESCG--KGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERN 4696

Query: 206  C 206
            C
Sbjct: 4697 C 4697



 Score = 28.1 bits (61), Expect = 8.5
 Identities = 13/27 (48%), Positives = 17/27 (62%), Gaps = 5/27 (18%)

Query: 151  SEWNPWSPCTKKGKTCGFKRGTETRVR 177
            SEW+ W  CT   ++CG  RG +TR R
Sbjct: 4590 SEWSLWEECT---RSCG--RGNQTRTR 4611


>gi|168229156 NFKB activating protein [Homo sapiens]
          Length = 415

 Score = 41.6 bits (96), Expect = 7e-04
 Identities = 23/75 (30%), Positives = 42/75 (56%), Gaps = 1/75 (1%)

Query: 191 PPTNETRKCTVQRKKCQKGERGK-KGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRE 249
           P  + T   T + +K +K  R K + ++R++KK +K + K+   DS S   S+      +
Sbjct: 168 PKKSTTSASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSETDSSDED 227

Query: 250 NKQQQKKRKVQDKQK 264
           NK++ KK K ++K+K
Sbjct: 228 NKRRAKKAKKKEKKK 242



 Score = 32.7 bits (73), Expect = 0.35
 Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)

Query: 186 KGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIP 245
           K      T+E  K     +  ++ ++ +K +  KRK     E  ++  DS++ +SS E  
Sbjct: 170 KSTTSASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSET-DSSDEDN 228

Query: 246 EQRENKQQQKKRKVQDKQK 264
           ++R  K ++K++K + + K
Sbjct: 229 KRRAKKAKKKEKKKKHRSK 247


>gi|190341087 spondin 2, extracellular matrix protein [Homo sapiens]
          Length = 331

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 20/52 (38%), Positives = 28/52 (53%), Gaps = 4/52 (7%)

Query: 148 CEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKC 199
           CEVS W+ W  C   G  CG + GT++R R +   P+  G+ CP   E  +C
Sbjct: 278 CEVSLWSSWGLC---GGHCG-RLGTKSRTRYVRVQPANNGSPCPELEEEAEC 325


>gi|6912682 spondin 2, extracellular matrix protein [Homo sapiens]
          Length = 331

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 20/52 (38%), Positives = 28/52 (53%), Gaps = 4/52 (7%)

Query: 148 CEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKC 199
           CEVS W+ W  C   G  CG + GT++R R +   P+  G+ CP   E  +C
Sbjct: 278 CEVSLWSSWGLC---GGHCG-RLGTKSRTRYVRVQPANNGSPCPELEEEAEC 325


>gi|209969800 RPE-spondin [Homo sapiens]
          Length = 264

 Score = 40.4 bits (93), Expect = 0.002
 Identities = 20/52 (38%), Positives = 23/52 (44%), Gaps = 5/52 (9%)

Query: 148 CEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKC 199
           C V EW+PWS C  + K       T  R R + Q P   G  CPP  E   C
Sbjct: 75  CFVGEWSPWSGCADQCKPT-----TRVRRRSVQQEPQNGGAPCPPLEERAGC 121


>gi|116734855 cysteine-rich with EGF-like domains 1 isoform 3 [Homo
           sapiens]
          Length = 420

 Score = 40.4 bits (93), Expect = 0.002
 Identities = 45/169 (26%), Positives = 66/169 (39%), Gaps = 13/169 (7%)

Query: 74  GVCLSSCPSGYY-GTRYPDINKCTKCKADCDTCFN--KNFCTKCKSGFYLHLGKCLDNCP 130
           G     C  GY+   R      C+ C   C  C    ++ C +CK G+ LH  KC+D   
Sbjct: 189 GEACGQCGLGYFEAERNASHLVCSACFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDE 248

Query: 131 EGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTC-GFKRGTETRVREIIQHPSAKGNL 189
            G E  N    C +   C  +E +    C    K C G       R ++        G+ 
Sbjct: 249 CGTEGAN----CGADQFCVNTEGS--YECRDCAKACLGCMGAGPGRCKKCSPGYQQVGSK 302

Query: 190 CPPTN--ETRKCTVQRKKCQKGERGKKGRERKRKKPNKGES-KEAIPDS 235
           C   +  ET  C  + K+C+  E G +    +  K  +G   KE IP+S
Sbjct: 303 CLDVDECETEVCPGENKQCENTEGGYRCICAEGYKQMEGICVKEQIPES 351


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,866,890
Number of Sequences: 37866
Number of extensions: 589406
Number of successful extensions: 5835
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 152
Number of HSP's successfully gapped in prelim test: 311
Number of HSP's that attempted gapping in prelim test: 4065
Number of HSP's gapped (non-prelim): 1679
length of query: 272
length of database: 18,247,518
effective HSP length: 101
effective length of query: 171
effective length of database: 14,423,052
effective search space: 2466341892
effective search space used: 2466341892
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.