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Search of human proteins with 18482373
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18482373 WD repeat and FYVE domain containing 1 [Homo
sapiens]
(410 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18482373 WD repeat and FYVE domain containing 1 [Homo sapiens] 865 0.0
gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens] 570 e-163
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 79 6e-15
gi|4758528 hepatocyte growth factor-regulated tyrosine kinase su... 75 8e-14
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 75 1e-13
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 75 1e-13
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 75 1e-13
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 72 9e-13
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 72 9e-13
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 66 5e-11
gi|23199987 WD repeat domain 5B [Homo sapiens] 60 4e-09
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 60 5e-09
gi|13375827 phafin 2 [Homo sapiens] 60 5e-09
gi|113865883 WD repeat domain 38 [Homo sapiens] 59 6e-09
gi|26665869 WD repeat domain 51B [Homo sapiens] 59 6e-09
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 59 1e-08
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 59 1e-08
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 59 1e-08
gi|16554629 WD repeat domain 5 [Homo sapiens] 58 1e-08
gi|16554627 WD repeat domain 5 [Homo sapiens] 58 1e-08
gi|55741864 zinc finger, FYVE domain containing 28 [Homo sapiens] 57 2e-08
gi|32189425 WD repeat domain 69 [Homo sapiens] 57 2e-08
gi|31543297 neutral sphingomyelinase (N-SMase) activation associ... 56 7e-08
gi|221625547 neutral sphingomyelinase (N-SMase) activation assoc... 56 7e-08
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 55 9e-08
gi|21071067 TBP-associated factor 5 [Homo sapiens] 55 1e-07
gi|31317270 WD repeat and FYVE domain containing 3 isoform 3 [Ho... 55 1e-07
gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Ho... 55 1e-07
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 54 2e-07
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 54 3e-07
>gi|18482373 WD repeat and FYVE domain containing 1 [Homo sapiens]
Length = 410
Score = 865 bits (2236), Expect = 0.0
Identities = 410/410 (100%), Positives = 410/410 (100%)
Query: 1 MAAEIHSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYW 60
MAAEIHSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYW
Sbjct: 1 MAAEIHSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYW 60
Query: 61 PSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAI 120
PSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAI
Sbjct: 61 PSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAI 120
Query: 121 IFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQIT 180
IFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQIT
Sbjct: 121 IFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQIT 180
Query: 181 LLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQG 240
LLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQG
Sbjct: 181 LLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQG 240
Query: 241 HHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVSREEAPQWLESDSCQKCEQPFFWNIKQ 300
HHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVSREEAPQWLESDSCQKCEQPFFWNIKQ
Sbjct: 241 HHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVSREEAPQWLESDSCQKCEQPFFWNIKQ 300
Query: 301 MWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDEDRTSLA 360
MWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDEDRTSLA
Sbjct: 301 MWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDEDRTSLA 360
Query: 361 TFHEGKHNISHMSMDIARGLMVTCGTDRIVKIWDMTPVVGCSLATGFSPH 410
TFHEGKHNISHMSMDIARGLMVTCGTDRIVKIWDMTPVVGCSLATGFSPH
Sbjct: 361 TFHEGKHNISHMSMDIARGLMVTCGTDRIVKIWDMTPVVGCSLATGFSPH 410
>gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens]
Length = 400
Score = 570 bits (1470), Expect = e-163
Identities = 247/399 (61%), Positives = 324/399 (81%)
Query: 1 MAAEIHSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYW 60
MAAEI +P + +P+LL ++EG Q+ V A+++PKE+GVI+ SEDRT+RVWLKRDSGQYW
Sbjct: 1 MAAEIQPKPLTRKPILLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYW 60
Query: 61 PSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAI 120
PS+YH M SPCS M+++ ++RR+ +G DNG + EF +SED+NKM +K Y AHQ+RV+ I
Sbjct: 61 PSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMI 120
Query: 121 IFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQIT 180
+F L EWV+STG DK +W C+ SG LG + ++ AS LQ+D +T++ F+GD+SGQ+T
Sbjct: 121 LFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDHSGQVT 180
Query: 181 LLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQG 240
+LKLEQ C+++TT +GH G V L WDP+QR+LFSG+SD+S+IMWDIGGRKG + LQG
Sbjct: 181 ILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQG 240
Query: 241 HHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVSREEAPQWLESDSCQKCEQPFFWNIKQ 300
H+D+VQ+L Y Q TRQL+SC DGGI VWNMDV R+E P+WL+SDSCQKC+QPFFWN KQ
Sbjct: 241 HNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQ 300
Query: 301 MWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDEDRTSLA 360
MWD+K +GLRQHHCRKCG+AVCGKCSSKRSS P+MGFEF+VRVCDSC+++I DE+R A
Sbjct: 301 MWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDEERAPTA 360
Query: 361 TFHEGKHNISHMSMDIARGLMVTCGTDRIVKIWDMTPVV 399
TFH+ KHNI H+ D RG ++T GTD+++K+WDMTPVV
Sbjct: 361 TFHDSKHNIVHVHFDATRGWLLTSGTDKVIKLWDMTPVV 399
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 79.3 bits (194), Expect = 6e-15
Identities = 61/270 (22%), Positives = 118/270 (43%), Gaps = 21/270 (7%)
Query: 39 VITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVS 98
VI AS D+T+R W W Y T C + D + + G D + +
Sbjct: 160 VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK---FSPDGKYVVSGFDVDHGICIMDA 216
Query: 99 EDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVS-WMCTRSGNMLG--RHFFT 155
E+ ++ IK + H +++ F ++ V S D+C+ W T +L +
Sbjct: 217 ENITTVSVIKDH--HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274
Query: 156 SWASCLQYDFDTQYAFVGDYSGQITLLKLE----QNTCSVITTLKGHEGSVACLWWDPIQ 211
+ ++C + F + + + + + +N + +T ++GHEGSV+ +
Sbjct: 275 AISNCC-FTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS 333
Query: 212 RLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNM 271
L SG D ++ +WD+ R L L+GH+D V + + ++S S D + +WN+
Sbjct: 334 SFLISGGFDRTVAIWDV-AEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNI 392
Query: 272 D-------VSREEAPQWLESDSCQKCEQPF 294
+ V + + L+ C++C++PF
Sbjct: 393 EEIDEIPLVIKYKKAVGLKLKQCERCDRPF 422
Score = 29.6 bits (65), Expect = 5.2
Identities = 11/32 (34%), Positives = 21/32 (65%)
Query: 20 IEGHQDAVTAALLIPKEDGVITASEDRTIRVW 51
++GH D V + + +++AS+DRT+R+W
Sbjct: 359 LKGHNDWVMDVAISNNKKWILSASKDRTMRLW 390
>gi|4758528 hepatocyte growth factor-regulated tyrosine kinase
substrate [Homo sapiens]
Length = 777
Score = 75.5 bits (184), Expect = 8e-14
Identities = 32/76 (42%), Positives = 44/76 (57%), Gaps = 11/76 (14%)
Query: 276 EEAPQWLESDSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPVM 335
E AP W++++ C +C F + R+HHCR CGQ CGKCSSK S+ P
Sbjct: 155 ERAPDWVDAEECHRCRVQF-----------GVMTRKHHCRACGQIFCGKCSSKYSTIPKF 203
Query: 336 GFEFQVRVCDSCYDSI 351
G E +VRVC+ CY+ +
Sbjct: 204 GIEKEVRVCEPCYEQL 219
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 74.7 bits (182), Expect = 1e-13
Identities = 67/240 (27%), Positives = 106/240 (44%), Gaps = 17/240 (7%)
Query: 36 EDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEF 95
++ +I+ D +I++W K HT S + +D R I G + V +
Sbjct: 250 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTG----SVLCLQYDERVIVTGSSDSTVRVW 305
Query: 96 HVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFT 155
D N + T H V + FS S V M + + L R
Sbjct: 306 ----DVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVG 361
Query: 156 SWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLF 215
A+ DFD +Y + SG T+ +TC + TL GH+ +ACL + RL+
Sbjct: 362 HRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVV 417
Query: 216 SGASDNSIIMWDIGGRKGRTL-LLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVS 274
SG+SDN+I +WDI G L +L+GH + V+ C +++VS + DG I VW++ +
Sbjct: 418 SGSSDNTIRLWDI--ECGACLRVLEGHEELVR--CIRFDNKRIVSGAYDGKIKVWDLQAA 473
Score = 35.8 bits (81), Expect = 0.072
Identities = 14/37 (37%), Positives = 21/37 (56%)
Query: 367 HNISHMSMDIARGLMVTCGTDRIVKIWDMTPVVGCSL 403
HN + + + + GLMVTC DR + +WDM +L
Sbjct: 319 HNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITL 355
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 74.7 bits (182), Expect = 1e-13
Identities = 67/240 (27%), Positives = 106/240 (44%), Gaps = 17/240 (7%)
Query: 36 EDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEF 95
++ +I+ D +I++W K HT S + +D R I G + V +
Sbjct: 216 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTG----SVLCLQYDERVIVTGSSDSTVRVW 271
Query: 96 HVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFT 155
D N + T H V + FS S V M + + L R
Sbjct: 272 ----DVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVG 327
Query: 156 SWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLF 215
A+ DFD +Y + SG T+ +TC + TL GH+ +ACL + RL+
Sbjct: 328 HRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVV 383
Query: 216 SGASDNSIIMWDIGGRKGRTL-LLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVS 274
SG+SDN+I +WDI G L +L+GH + V+ C +++VS + DG I VW++ +
Sbjct: 384 SGSSDNTIRLWDI--ECGACLRVLEGHEELVR--CIRFDNKRIVSGAYDGKIKVWDLQAA 439
Score = 35.8 bits (81), Expect = 0.072
Identities = 14/37 (37%), Positives = 21/37 (56%)
Query: 367 HNISHMSMDIARGLMVTCGTDRIVKIWDMTPVVGCSL 403
HN + + + + GLMVTC DR + +WDM +L
Sbjct: 285 HNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITL 321
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 74.7 bits (182), Expect = 1e-13
Identities = 67/240 (27%), Positives = 106/240 (44%), Gaps = 17/240 (7%)
Query: 36 EDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEF 95
++ +I+ D +I++W K HT S + +D R I G + V +
Sbjct: 237 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTG----SVLCLQYDERVIVTGSSDSTVRVW 292
Query: 96 HVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFT 155
D N + T H V + FS S V M + + L R
Sbjct: 293 ----DVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVG 348
Query: 156 SWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLF 215
A+ DFD +Y + SG T+ +TC + TL GH+ +ACL + RL+
Sbjct: 349 HRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVV 404
Query: 216 SGASDNSIIMWDIGGRKGRTL-LLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVS 274
SG+SDN+I +WDI G L +L+GH + V+ C +++VS + DG I VW++ +
Sbjct: 405 SGSSDNTIRLWDI--ECGACLRVLEGHEELVR--CIRFDNKRIVSGAYDGKIKVWDLQAA 460
Score = 35.8 bits (81), Expect = 0.072
Identities = 14/37 (37%), Positives = 21/37 (56%)
Query: 367 HNISHMSMDIARGLMVTCGTDRIVKIWDMTPVVGCSL 403
HN + + + + GLMVTC DR + +WDM +L
Sbjct: 306 HNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITL 342
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 72.0 bits (175), Expect = 9e-13
Identities = 66/234 (28%), Positives = 103/234 (44%), Gaps = 17/234 (7%)
Query: 39 VITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVS 98
+++ D TI++W K HT S + +D R I G + V +
Sbjct: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTG----SVLCLQYDERVIITGSSDSTVRVW--- 332
Query: 99 EDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWA 158
D N + T H V + F+ S V M + + L R A
Sbjct: 333 -DVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRA 391
Query: 159 SCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGA 218
+ DFD +Y + SG T+ +TC + TL GH+ +ACL + RL+ SG+
Sbjct: 392 AVNVVDFDDKY--IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGS 447
Query: 219 SDNSIIMWDIGGRKGRTL-LLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNM 271
SDN+I +WDI G L +L+GH + V+ C +++VS + DG I VW++
Sbjct: 448 SDNTIRLWDI--ECGACLRVLEGHEELVR--CIRFDNKRIVSGAYDGKIKVWDL 497
Score = 34.3 bits (77), Expect = 0.21
Identities = 23/71 (32%), Positives = 38/71 (53%), Gaps = 5/71 (7%)
Query: 202 VACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQLTRQLVSCS 261
V CL +D + + SG DN+I +WD + + +L GH V LC R +++ S
Sbjct: 270 VYCLQYD--DQKIVSGLRDNTIKIWDKNTLECKRILT-GHTGSV--LCLQYDERVIITGS 324
Query: 262 SDGGIAVWNMD 272
SD + VW+++
Sbjct: 325 SDSTVRVWDVN 335
Score = 30.4 bits (67), Expect = 3.0
Identities = 23/102 (22%), Positives = 43/102 (42%), Gaps = 17/102 (16%)
Query: 297 NIKQMWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDEDR 356
N ++WD TL ++ G +C + ++ +V + S +++ D
Sbjct: 287 NTIKIWDKNTLECKRILTGHTGSVLC------------LQYDERVIITGSSDSTVRVWDV 334
Query: 357 TS---LATFHEGKHNISHMSMDIARGLMVTCGTDRIVKIWDM 395
+ L T + H+ + G+MVTC DR + +WDM
Sbjct: 335 NTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDM 374
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 72.0 bits (175), Expect = 9e-13
Identities = 66/234 (28%), Positives = 103/234 (44%), Gaps = 17/234 (7%)
Query: 39 VITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVS 98
+++ D TI++W K HT S + +D R I G + V +
Sbjct: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTG----SVLCLQYDERVIITGSSDSTVRVW--- 368
Query: 99 EDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWA 158
D N + T H V + F+ S V M + + L R A
Sbjct: 369 -DVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRA 427
Query: 159 SCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGA 218
+ DFD +Y + SG T+ +TC + TL GH+ +ACL + RL+ SG+
Sbjct: 428 AVNVVDFDDKY--IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGS 483
Query: 219 SDNSIIMWDIGGRKGRTL-LLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNM 271
SDN+I +WDI G L +L+GH + V+ C +++VS + DG I VW++
Sbjct: 484 SDNTIRLWDI--ECGACLRVLEGHEELVR--CIRFDNKRIVSGAYDGKIKVWDL 533
Score = 34.3 bits (77), Expect = 0.21
Identities = 23/71 (32%), Positives = 38/71 (53%), Gaps = 5/71 (7%)
Query: 202 VACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQLTRQLVSCS 261
V CL +D + + SG DN+I +WD + + +L GH V LC R +++ S
Sbjct: 306 VYCLQYD--DQKIVSGLRDNTIKIWDKNTLECKRILT-GHTGSV--LCLQYDERVIITGS 360
Query: 262 SDGGIAVWNMD 272
SD + VW+++
Sbjct: 361 SDSTVRVWDVN 371
Score = 30.4 bits (67), Expect = 3.0
Identities = 23/102 (22%), Positives = 43/102 (42%), Gaps = 17/102 (16%)
Query: 297 NIKQMWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDEDR 356
N ++WD TL ++ G +C + ++ +V + S +++ D
Sbjct: 323 NTIKIWDKNTLECKRILTGHTGSVLC------------LQYDERVIITGSSDSTVRVWDV 370
Query: 357 TS---LATFHEGKHNISHMSMDIARGLMVTCGTDRIVKIWDM 395
+ L T + H+ + G+MVTC DR + +WDM
Sbjct: 371 NTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDM 410
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 66.2 bits (160), Expect = 5e-11
Identities = 42/166 (25%), Positives = 78/166 (46%), Gaps = 5/166 (3%)
Query: 112 AHQNRVSAIIFSLATEWVISTGHDKCVS--WMCTRSGNMLGRHFFTSWASCLQYDFDTQY 169
AH + VS+++ A+ +++TG D C W + ++ TS ++ + +
Sbjct: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL 77
Query: 170 AFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIG 229
G SG I + LE ++ TL GH+ ++ L + P + SG+ D +I +WDI
Sbjct: 78 IVAGSQSGSIRVWDLE--AAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDI- 134
Query: 230 GRKGRTLLLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVSR 275
RKG +GH V+ L + + L S + D + +W++ +
Sbjct: 135 RRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK 180
Score = 49.7 bits (117), Expect = 5e-06
Identities = 46/215 (21%), Positives = 89/215 (41%), Gaps = 12/215 (5%)
Query: 17 LSKIEGHQDAVTAALLIPKEDG--VITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAM 74
L +I H V++ L++ K G + T +D + +W HT SP ++
Sbjct: 13 LQEIVAHASNVSS-LVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHT--SPVESV 69
Query: 75 AYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGH 134
+ I G +G++ + D ++T H+ + ++ F E+V S
Sbjct: 70 RLNTPEELIVAGSQSGSIRVW----DLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQ 125
Query: 135 DKCVS-WMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVIT 193
D + W R G + + CL++ D ++ + + T+ + +++
Sbjct: 126 DTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKW--LASAADDHTVKLWDLTAGKMMS 183
Query: 194 TLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDI 228
GH G V + + P + LL SG+SD +I WD+
Sbjct: 184 EFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218
Score = 44.3 bits (103), Expect = 2e-04
Identities = 41/210 (19%), Positives = 83/210 (39%), Gaps = 7/210 (3%)
Query: 12 SRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPC 71
++P + + GH V + L E+ ++ S+ +IRVW ++ + ++ A+ C
Sbjct: 51 NKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVW-DLEAAKILRTLMGHKANIC 109
Query: 72 SAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVIS 131
S + +H + G + + + D + + Y H V + FS +W+ S
Sbjct: 110 S-LDFHPYGEFVASGSQDTNIKLW----DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLAS 164
Query: 132 TGHDKCVSWMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSV 191
D V +G M+ F +F + S T+ + V
Sbjct: 165 AADDHTVKLWDLTAGKMMS-EFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQV 223
Query: 192 ITTLKGHEGSVACLWWDPIQRLLFSGASDN 221
++ ++G G V + ++P L+SG D+
Sbjct: 224 VSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 60.1 bits (144), Expect = 4e-09
Identities = 58/269 (21%), Positives = 111/269 (41%), Gaps = 16/269 (5%)
Query: 9 PQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIY-HTM 67
P++ L + GH +AV++ P + + ++S DR I +W D G+Y ++Y H +
Sbjct: 26 PENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYD-GKYEKTLYGHNL 84
Query: 68 ASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATE 127
S +A+ DS R+ D+ + + D +KT H N V F+ +
Sbjct: 85 --EISDVAWSSDSSRLVSASDDKTLKLW----DVRSGKCLKTLKGHSNYVFCCNFNPPSN 138
Query: 128 WVISTGHDKCVSWMCTRSGNMLGR-HFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQ 186
+IS D+ V ++G L + S + ++ G Y G +
Sbjct: 139 LIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAAS 198
Query: 187 NTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQ 246
C + T + V+ + + P + + + DN++ +WD +GR L H +
Sbjct: 199 GQC-LKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYS--RGRCLKTYTGHKNEK 255
Query: 247 SLCYLQLT----RQLVSCSSDGGIAVWNM 271
+ + + +VS S D + +WN+
Sbjct: 256 YCIFANFSVTGGKWIVSGSEDNLVYIWNL 284
Score = 31.6 bits (70), Expect = 1.4
Identities = 13/39 (33%), Positives = 26/39 (66%), Gaps = 2/39 (5%)
Query: 16 LLSKIEGHQDAVTAALLIPKEDGVITAS--EDRTIRVWL 52
++ K++GH D V +A P E+ + +A+ D+TI++W+
Sbjct: 289 IVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWM 327
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 59.7 bits (143), Expect = 5e-09
Identities = 63/283 (22%), Positives = 115/283 (40%), Gaps = 38/283 (13%)
Query: 13 RPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIY-HTMASPC 71
RP + GH+ VT + P +++ASED TI+VW ++G + ++ HT
Sbjct: 97 RPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVW-DYETGDFERTLKGHT--DSV 153
Query: 72 SAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVIS 131
+++ H + + + + + DF I+T H + VS++ + ++S
Sbjct: 154 QDISFDHSGKLLASCSADMTIKLW----DFQGFECIRTMHGHDHNVSSVAIMPNGDHIVS 209
Query: 132 TGHDKCVSWMCTRSGNMLGRHFFT---SWASCLQYDFDTQYAFVGDYSGQITLLKLEQNT 188
DK + ++G + FT W ++ + D + S T+ T
Sbjct: 210 ASRDKTIKMWEVQTGYCV--KTFTGHREWVRMVRPNQDG--TLIASCSNDQTVRVWVVAT 265
Query: 189 CSVITTLKGHEGSVACLWWDPIQR--------------------LLFSGASDNSIIMWDI 228
L+ HE V C+ W P L SG+ D +I MWD+
Sbjct: 266 KECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV 325
Query: 229 GGRKGRTLL-LQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWN 270
G L+ L GH + V+ + + + ++SC+ D + VW+
Sbjct: 326 S--TGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWD 366
Score = 42.4 bits (98), Expect = 8e-04
Identities = 32/108 (29%), Positives = 51/108 (47%), Gaps = 3/108 (2%)
Query: 165 FDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSII 224
F ++ + S T+ + T TLKGH SV + +D +LL S ++D +I
Sbjct: 116 FHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 225 MWDIGGRKG-RTLLLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNM 271
+WD G + RT+ GH V S+ + +VS S D I +W +
Sbjct: 176 LWDFQGFECIRTM--HGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV 221
>gi|13375827 phafin 2 [Homo sapiens]
Length = 249
Score = 59.7 bits (143), Expect = 5e-09
Identities = 32/85 (37%), Positives = 42/85 (49%), Gaps = 14/85 (16%)
Query: 274 SREEAPQWL---ESDSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRKCGQAVCGKCSSKRS 330
S E A W+ E+ C +C++ F + R+HHCRKCG VCG CS KR
Sbjct: 142 SNEHAAVWVPDSEATVCMRCQKAKFTPVN----------RRHHCRKCGFVVCGPCSEKRF 191
Query: 331 SYPVMGFEFQVRVCDSCYDSIKDED 355
P + VR+CD CYD + D
Sbjct: 192 LLPSQSSK-PVRICDFCYDLLSAGD 215
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 59.3 bits (142), Expect = 6e-09
Identities = 45/167 (26%), Positives = 76/167 (45%), Gaps = 6/167 (3%)
Query: 107 IKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWMCTRSGNMLGR-HFFTSWASCLQYDF 165
+K + H V++ FS + +++ D CV TRSG +L R T ++
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
Query: 166 DTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIM 225
D + L + + C + LKGH+ SV + + P R L SG D +++
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKC--LRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131
Query: 226 WDIGGRKGRTL-LLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNM 271
WD+ + G+ L LL GH D +QS + L + S D + +W++
Sbjct: 132 WDV--QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Score = 49.7 bits (117), Expect = 5e-06
Identities = 59/256 (23%), Positives = 96/256 (37%), Gaps = 12/256 (4%)
Query: 23 HQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRR 82
H V ++ P ++T SED + W R W HT P + D
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHT--GPVKFCRFSPDGHL 77
Query: 83 IFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWMC 142
+ V + V+ + ++ HQ V + FS + + S G DK V
Sbjct: 78 FASASCDCTVRLWDVA----RAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 143 TRSGNMLGRHFFTSWASCLQYDFD--TQYAFVGDYSGQITLLKLEQNTCSVI-TTLKGHE 199
+SG ML R S DF G + + + L T +V L+GH
Sbjct: 134 VQSGQML-RLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHS 192
Query: 200 GSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQLTRQLVS 259
+++CL + LL SG+ D +I +W + L+GH V+S+ + L S
Sbjct: 193 ANISCLCYS-ASGLLASGSWDKTIHIWK-PTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
Query: 260 CSSDGGIAVWNMDVSR 275
+ VW+ + +
Sbjct: 251 AGYSRMVKVWDCNTGK 266
Score = 32.3 bits (72), Expect = 0.80
Identities = 39/208 (18%), Positives = 74/208 (35%), Gaps = 49/208 (23%)
Query: 16 LLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMA 75
+L + GH+D++ ++ P + + T S D T+ +W D P++ H
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW---DLRMVTPAVSH---------- 185
Query: 76 YHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHD 135
+ H +S + +S A+ + S D
Sbjct: 186 --------------------------------QALEGHSANISCLCYS-ASGLLASGSWD 212
Query: 136 KCVS-WMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITT 194
K + W T S ++ +W + + D + YS + + + NT + T
Sbjct: 213 KTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV--WDCNTGKCLET 270
Query: 195 LKGHEGSVACLWWDPIQRLLFSGASDNS 222
LKG + P ++L SGA+D +
Sbjct: 271 LKGVLDVAHTCAFTPDGKILVSGAADQT 298
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 59.3 bits (142), Expect = 6e-09
Identities = 51/249 (20%), Positives = 106/249 (42%), Gaps = 10/249 (4%)
Query: 22 GHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSR 81
GH+D VT+ P + + +AS DRT+R+W+ G++ HT +P ++ + D +
Sbjct: 58 GHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHT--APVRSVDFSADGQ 115
Query: 82 RIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWM 141
+ ++ ++ + + F+ + H + V FS ++S DK +
Sbjct: 116 FLATASEDKSIKVW----SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Query: 142 CTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGS 201
T + + +F S DF+ + T+ + ++ + H G
Sbjct: 172 DTTNKQCV-NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGG 230
Query: 202 VACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTL-LLQGHHDKVQSLCYLQLTRQLVSC 260
V C+ + P L + +SD ++ + D+ +GR + LQGH V ++ + + S
Sbjct: 231 VNCISFHPSGNYLITASSDGTLKILDL--LEGRLIYTLQGHTGPVFTVSFSKGGELFASG 288
Query: 261 SSDGGIAVW 269
+D + +W
Sbjct: 289 GADTQVLLW 297
Score = 49.3 bits (116), Expect = 6e-06
Identities = 51/261 (19%), Positives = 99/261 (37%), Gaps = 14/261 (5%)
Query: 14 PVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSA 73
PVL +GH+ A+T+ L P + TAS D + +W + + + + H
Sbjct: 8 PVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQ 67
Query: 74 MAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTG 133
+ H + + + + + K + K AH V ++ FS +++ +
Sbjct: 68 FSPHGN---LLASASRDRTVRLWIPDKRGKFSEFK---AHTAPVRSVDFSADGQFLATAS 121
Query: 134 HDKCVS-WMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVI 192
DK + W R + + T W C ++ D + I + C +
Sbjct: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC--V 179
Query: 193 TTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLL--LQGHHDKVQSLCY 250
G + ++P + S SD ++ +WD+ K LL Q H V + +
Sbjct: 180 NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNK---LLQHYQVHSGGVNCISF 236
Query: 251 LQLTRQLVSCSSDGGIAVWNM 271
L++ SSDG + + ++
Sbjct: 237 HPSGNYLITASSDGTLKILDL 257
Score = 32.0 bits (71), Expect = 1.0
Identities = 20/77 (25%), Positives = 34/77 (44%), Gaps = 1/77 (1%)
Query: 196 KGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQLTR 255
KGH+ ++ L P + L + + D +++W+ R GH D V S+ +
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPH-ARAYRYVGHKDVVTSVQFSPHGN 73
Query: 256 QLVSCSSDGGIAVWNMD 272
L S S D + +W D
Sbjct: 74 LLASASRDRTVRLWIPD 90
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 58.5 bits (140), Expect = 1e-08
Identities = 58/272 (21%), Positives = 109/272 (40%), Gaps = 18/272 (6%)
Query: 6 HSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYH 65
H +PQS + GH+DAVT P + + S D+T+R+W+ G+ +++
Sbjct: 9 HMKPQSRA----YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE--STVFR 62
Query: 66 TMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLA 125
+ ++ + D + D+ V + ++ F+ + H N V FS
Sbjct: 63 AHTATVRSVHFCSDGQSFVTASDDKTVKVWAT----HRQKFLFSLSQHINWVRCAKFSPD 118
Query: 126 TEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWASCLQY-DFDTQYAFVGDYSGQITLLKL 184
++S DK V S + H + + Y DF + T+
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECV--HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 176
Query: 185 EQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTL-LLQGHHD 243
+ T ++ + H +V L + P L + +SD+++ + D+ +GR L L GH
Sbjct: 177 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL--MEGRLLYTLHGHQG 234
Query: 244 KVQSLCYLQLTRQLVSCSSDGGIAVW--NMDV 273
++ + + S SD + VW N D+
Sbjct: 235 PATTVAFSRTGEYFASGGSDEQVMVWKSNFDI 266
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 58.5 bits (140), Expect = 1e-08
Identities = 58/272 (21%), Positives = 109/272 (40%), Gaps = 18/272 (6%)
Query: 6 HSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYH 65
H +PQS + GH+DAVT P + + S D+T+R+W+ G+ +++
Sbjct: 47 HMKPQSRA----YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE--STVFR 100
Query: 66 TMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLA 125
+ ++ + D + D+ V + ++ F+ + H N V FS
Sbjct: 101 AHTATVRSVHFCSDGQSFVTASDDKTVKVWAT----HRQKFLFSLSQHINWVRCAKFSPD 156
Query: 126 TEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWASCLQY-DFDTQYAFVGDYSGQITLLKL 184
++S DK V S + H + + Y DF + T+
Sbjct: 157 GRLIVSASDDKTVKLWDKSSRECV--HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214
Query: 185 EQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTL-LLQGHHD 243
+ T ++ + H +V L + P L + +SD+++ + D+ +GR L L GH
Sbjct: 215 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL--MEGRLLYTLHGHQG 272
Query: 244 KVQSLCYLQLTRQLVSCSSDGGIAVW--NMDV 273
++ + + S SD + VW N D+
Sbjct: 273 PATTVAFSRTGEYFASGGSDEQVMVWKSNFDI 304
Score = 43.9 bits (102), Expect = 3e-04
Identities = 52/265 (19%), Positives = 98/265 (36%), Gaps = 12/265 (4%)
Query: 9 PQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMA 68
P + P L +GH+DAVT + + S D + VW + + + H A
Sbjct: 4 PCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDA 63
Query: 69 SPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEW 128
C + S + + V N + AH V ++ F +
Sbjct: 64 VTCVNFS---PSGHLLASGSRDKTVRIWVP---NVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 129 VISTGHDKCVS-WMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQN 187
++ DK V W R + +W C ++ D + + S T+ +++
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKS 175
Query: 188 TCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLL-LQGHHDKVQ 246
+ + + H G V + + P + + DN++ +WD+ R R L Q H V
Sbjct: 176 SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV--RTHRLLQHYQLHSAAVN 233
Query: 247 SLCYLQLTRQLVSCSSDGGIAVWNM 271
L + L++ SSD + + ++
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDL 258
Score = 36.6 bits (83), Expect = 0.042
Identities = 22/81 (27%), Positives = 38/81 (46%), Gaps = 1/81 (1%)
Query: 196 KGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQLTR 255
KGH +V C+ + + L SG+ D+ +++W + + R GH D V + +
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQS-RAYRFTGHKDAVTCVNFSPSGH 74
Query: 256 QLVSCSSDGGIAVWNMDVSRE 276
L S S D + +W +V E
Sbjct: 75 LLASGSRDKTVRIWVPNVKGE 95
Score = 29.6 bits (65), Expect = 5.2
Identities = 44/221 (19%), Positives = 81/221 (36%), Gaps = 62/221 (28%)
Query: 149 LGRHF--FTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLW 206
L RHF +C+ + +T+ G + + ++ + + T GH+ +V C+
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVN 68
Query: 207 WDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQ-----LT------- 254
+ P LL SG+ D ++ +W + KG + + + H V+S+ + +T
Sbjct: 69 FSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127
Query: 255 ------------------------------RQLVSCSSDGGIAVWNMDVSREEAPQWLE- 283
R +VS S D + +W+ SRE + E
Sbjct: 128 KVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS-SRECVHSYCEH 186
Query: 284 -----------SDSCQKCEQPFFWNIKQMWDTKTLGLRQHH 313
S +C N ++WD +T L QH+
Sbjct: 187 GGFVTYVDFHPSGTCIAAAG--MDNTVKVWDVRTHRLLQHY 225
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 58.5 bits (140), Expect = 1e-08
Identities = 58/272 (21%), Positives = 109/272 (40%), Gaps = 18/272 (6%)
Query: 6 HSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYH 65
H +PQS + GH+DAVT P + + S D+T+R+W+ G+ +++
Sbjct: 47 HMKPQSRA----YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE--STVFR 100
Query: 66 TMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLA 125
+ ++ + D + D+ V + ++ F+ + H N V FS
Sbjct: 101 AHTATVRSVHFCSDGQSFVTASDDKTVKVWAT----HRQKFLFSLSQHINWVRCAKFSPD 156
Query: 126 TEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWASCLQY-DFDTQYAFVGDYSGQITLLKL 184
++S DK V S + H + + Y DF + T+
Sbjct: 157 GRLIVSASDDKTVKLWDKSSRECV--HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214
Query: 185 EQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTL-LLQGHHD 243
+ T ++ + H +V L + P L + +SD+++ + D+ +GR L L GH
Sbjct: 215 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL--MEGRLLYTLHGHQG 272
Query: 244 KVQSLCYLQLTRQLVSCSSDGGIAVW--NMDV 273
++ + + S SD + VW N D+
Sbjct: 273 PATTVAFSRTGEYFASGGSDEQVMVWKSNFDI 304
Score = 43.9 bits (102), Expect = 3e-04
Identities = 52/265 (19%), Positives = 98/265 (36%), Gaps = 12/265 (4%)
Query: 9 PQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMA 68
P + P L +GH+DAVT + + S D + VW + + + H A
Sbjct: 4 PCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDA 63
Query: 69 SPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEW 128
C + S + + V N + AH V ++ F +
Sbjct: 64 VTCVNFS---PSGHLLASGSRDKTVRIWVP---NVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 129 VISTGHDKCVS-WMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQN 187
++ DK V W R + +W C ++ D + + S T+ +++
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKS 175
Query: 188 TCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLL-LQGHHDKVQ 246
+ + + H G V + + P + + DN++ +WD+ R R L Q H V
Sbjct: 176 SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV--RTHRLLQHYQLHSAAVN 233
Query: 247 SLCYLQLTRQLVSCSSDGGIAVWNM 271
L + L++ SSD + + ++
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDL 258
Score = 36.6 bits (83), Expect = 0.042
Identities = 22/81 (27%), Positives = 38/81 (46%), Gaps = 1/81 (1%)
Query: 196 KGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQLTR 255
KGH +V C+ + + L SG+ D+ +++W + + R GH D V + +
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQS-RAYRFTGHKDAVTCVNFSPSGH 74
Query: 256 QLVSCSSDGGIAVWNMDVSRE 276
L S S D + +W +V E
Sbjct: 75 LLASGSRDKTVRIWVPNVKGE 95
Score = 29.6 bits (65), Expect = 5.2
Identities = 44/221 (19%), Positives = 81/221 (36%), Gaps = 62/221 (28%)
Query: 149 LGRHF--FTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLW 206
L RHF +C+ + +T+ G + + ++ + + T GH+ +V C+
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVN 68
Query: 207 WDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQ-----LT------- 254
+ P LL SG+ D ++ +W + KG + + + H V+S+ + +T
Sbjct: 69 FSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127
Query: 255 ------------------------------RQLVSCSSDGGIAVWNMDVSREEAPQWLE- 283
R +VS S D + +W+ SRE + E
Sbjct: 128 KVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS-SRECVHSYCEH 186
Query: 284 -----------SDSCQKCEQPFFWNIKQMWDTKTLGLRQHH 313
S +C N ++WD +T L QH+
Sbjct: 187 GGFVTYVDFHPSGTCIAAAG--MDNTVKVWDVRTHRLLQHY 225
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 58.2 bits (139), Expect = 1e-08
Identities = 47/171 (27%), Positives = 76/171 (44%), Gaps = 20/171 (11%)
Query: 109 TYPAHQNRVSAIIFSLATEWVISTGHDKCVS-WMC-------TRSGNMLGRHFFTSWASC 160
T H VS++ FS EW+ S+ DK + W T SG+ LG S
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG-------ISD 92
Query: 161 LQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASD 220
+ + D+ + + + C + TLKGH V C ++P L+ SG+ D
Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKC--LKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 221 NSIIMWDIGGRKGRTL-LLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWN 270
S+ +WD+ + G+ L L H D V ++ + + +VS S DG +W+
Sbjct: 151 ESVRIWDV--KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 53.5 bits (127), Expect = 3e-07
Identities = 57/273 (20%), Positives = 112/273 (41%), Gaps = 18/273 (6%)
Query: 7 SRPQSSRP--VLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIY 64
S+P +P L + GH AV++ P + + ++S D+ I++W D G++ +I
Sbjct: 26 SKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD-GKFEKTIS 84
Query: 65 -HTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFS 123
H + S +A+ DS + D+ + + VS +KT H N V F+
Sbjct: 85 GHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSG----KCLKTLKGHSNYVFCCNFN 138
Query: 124 LATEWVISTGHDKCVSWMCTRSGNMLGR-HFFTSWASCLQYDFDTQYAFVGDYSGQITLL 182
+ ++S D+ V ++G L + S + ++ D Y G +
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 183 KLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHH 242
C + T + V+ + + P + + + DN++ +WD KG+ L H
Sbjct: 199 DTASGQC-LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--KGKCLKTYTGH 255
Query: 243 DKVQSLCYLQLT----RQLVSCSSDGGIAVWNM 271
+ + + + +VS S D + +WN+
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 49.3 bits (116), Expect = 6e-06
Identities = 58/261 (22%), Positives = 110/261 (42%), Gaps = 18/261 (6%)
Query: 20 IEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIY-HTMASPCSAMAYHH 78
I GH+ ++ + +++AS+D+T+++W SG+ ++ H+ C ++
Sbjct: 83 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIW-DVSSGKCLKTLKGHSNYVFCCN--FNP 139
Query: 79 DSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCV 138
S I G + +V + V +KT PAH + VSA+ F+ ++S+ +D
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTG----KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 139 SWMCTRSGNMLGRHF--FTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLK 196
T SG L S +++ + +Y + L + C + T
Sbjct: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC--LKTYT 253
Query: 197 GHEGSVACLWWD---PIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQL 253
GH+ C++ + + + SG+ DN + +W++ K LQGH D V S
Sbjct: 254 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL-QTKEIVQKLQGHTDVVISTACHPT 312
Query: 254 TRQLVSCS--SDGGIAVWNMD 272
+ S + +D I +W D
Sbjct: 313 ENIIASAALENDKTIKLWKSD 333
Score = 29.3 bits (64), Expect = 6.8
Identities = 12/38 (31%), Positives = 24/38 (63%), Gaps = 2/38 (5%)
Query: 16 LLSKIEGHQDAVTAALLIPKEDGVITAS--EDRTIRVW 51
++ K++GH D V + P E+ + +A+ D+TI++W
Sbjct: 293 IVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 58.2 bits (139), Expect = 1e-08
Identities = 47/171 (27%), Positives = 76/171 (44%), Gaps = 20/171 (11%)
Query: 109 TYPAHQNRVSAIIFSLATEWVISTGHDKCVS-WMC-------TRSGNMLGRHFFTSWASC 160
T H VS++ FS EW+ S+ DK + W T SG+ LG S
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG-------ISD 92
Query: 161 LQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASD 220
+ + D+ + + + C + TLKGH V C ++P L+ SG+ D
Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKC--LKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 221 NSIIMWDIGGRKGRTL-LLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWN 270
S+ +WD+ + G+ L L H D V ++ + + +VS S DG +W+
Sbjct: 151 ESVRIWDV--KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 53.5 bits (127), Expect = 3e-07
Identities = 57/273 (20%), Positives = 112/273 (41%), Gaps = 18/273 (6%)
Query: 7 SRPQSSRP--VLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIY 64
S+P +P L + GH AV++ P + + ++S D+ I++W D G++ +I
Sbjct: 26 SKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD-GKFEKTIS 84
Query: 65 -HTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFS 123
H + S +A+ DS + D+ + + VS +KT H N V F+
Sbjct: 85 GHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSG----KCLKTLKGHSNYVFCCNFN 138
Query: 124 LATEWVISTGHDKCVSWMCTRSGNMLGR-HFFTSWASCLQYDFDTQYAFVGDYSGQITLL 182
+ ++S D+ V ++G L + S + ++ D Y G +
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 183 KLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHH 242
C + T + V+ + + P + + + DN++ +WD KG+ L H
Sbjct: 199 DTASGQC-LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--KGKCLKTYTGH 255
Query: 243 DKVQSLCYLQLT----RQLVSCSSDGGIAVWNM 271
+ + + + +VS S D + +WN+
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 49.3 bits (116), Expect = 6e-06
Identities = 58/261 (22%), Positives = 110/261 (42%), Gaps = 18/261 (6%)
Query: 20 IEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIY-HTMASPCSAMAYHH 78
I GH+ ++ + +++AS+D+T+++W SG+ ++ H+ C ++
Sbjct: 83 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIW-DVSSGKCLKTLKGHSNYVFCCN--FNP 139
Query: 79 DSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCV 138
S I G + +V + V +KT PAH + VSA+ F+ ++S+ +D
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTG----KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 139 SWMCTRSGNMLGRHF--FTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLK 196
T SG L S +++ + +Y + L + C + T
Sbjct: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC--LKTYT 253
Query: 197 GHEGSVACLWWD---PIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQL 253
GH+ C++ + + + SG+ DN + +W++ K LQGH D V S
Sbjct: 254 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL-QTKEIVQKLQGHTDVVISTACHPT 312
Query: 254 TRQLVSCS--SDGGIAVWNMD 272
+ S + +D I +W D
Sbjct: 313 ENIIASAALENDKTIKLWKSD 333
Score = 29.3 bits (64), Expect = 6.8
Identities = 12/38 (31%), Positives = 24/38 (63%), Gaps = 2/38 (5%)
Query: 16 LLSKIEGHQDAVTAALLIPKEDGVITAS--EDRTIRVW 51
++ K++GH D V + P E+ + +A+ D+TI++W
Sbjct: 293 IVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|55741864 zinc finger, FYVE domain containing 28 [Homo sapiens]
Length = 887
Score = 57.4 bits (137), Expect = 2e-08
Identities = 30/90 (33%), Positives = 42/90 (46%), Gaps = 14/90 (15%)
Query: 262 SDGGIAVWNMDVSREEAPQWLESDSC---QKCEQPFFWNIKQMWDTKTLGLRQHHCRKCG 318
S +A D E+ P+W+ ++C C+ PF T+ R+HHCR CG
Sbjct: 795 SSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPF-----------TVIRRKHHCRSCG 843
Query: 319 QAVCGKCSSKRSSYPVMGFEFQVRVCDSCY 348
+ C +CSS + P G VRVC CY
Sbjct: 844 KIFCSRCSSHSAPLPRYGQVKPVRVCTHCY 873
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 57.4 bits (137), Expect = 2e-08
Identities = 71/310 (22%), Positives = 122/310 (39%), Gaps = 45/310 (14%)
Query: 108 KTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWMCTRSG---NMLGRHFFTSWASCLQYD 164
K AH ++ + + + I+ +D+ T SG N L H +A
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 165 FDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSII 224
+ + A G + L +E C T +GH + CL ++P L+ +G+ D +
Sbjct: 146 YGDKIA-TGSFDKTCKLWSVETGKC--YHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAK 202
Query: 225 MWDIGGRKGRTLLLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVSREEAPQWLES 284
+WDI + L+GH ++ SL + ++++ S D + VW+ D R+ +
Sbjct: 203 LWDIQNGE-EVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN---ILI 258
Query: 285 DSCQKCEQPFFWNIKQMWDTKTL--GLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQVR 342
C + F WD + G C K A GKC + + +
Sbjct: 259 GHCAEISSASF-----NWDCSLILTGSMDKTC-KLWDATNGKCVATLTGH-------DDE 305
Query: 343 VCDSCYD------SIKDEDRT----SLAT--------FHEGKHNISHMSMDIARGLMVTC 384
+ DSC+D + D T S AT HEG+ IS +S + ++T
Sbjct: 306 ILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGE--ISKISFNPQGNHLLTG 363
Query: 385 GTDRIVKIWD 394
+D+ +IWD
Sbjct: 364 SSDKTARIWD 373
Score = 54.7 bits (130), Expect = 2e-07
Identities = 54/252 (21%), Positives = 108/252 (42%), Gaps = 16/252 (6%)
Query: 22 GHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSR 81
GH + P+ V T S D T ++W ++ + + H+ + +++++
Sbjct: 175 GHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHS--AEIISLSFNTSGD 232
Query: 82 RIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDK-CVSW 140
RI G + V+ + ++ K+N + H +S+ F+ +++ DK C W
Sbjct: 233 RIITGSFDHTVVVWD-ADTGRKVNILI---GHCAEISSASFNWDCSLILTGSMDKTCKLW 288
Query: 141 MCTRSGNM--LGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGH 198
T + L H SC +D+ + G + C I L+GH
Sbjct: 289 DATNGKCVATLTGHDDEILDSC--FDYTGKLIATASADGTARIFSAATRKC--IAKLEGH 344
Query: 199 EGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTL-LLQGHHDKVQSLCYLQLTRQL 257
EG ++ + ++P L +G+SD + +WD + G+ L +L+GH D++ S + +
Sbjct: 345 EGEISKISFNPQGNHLLTGSSDKTARIWD--AQTGQCLQVLEGHTDEIFSCAFNYKGNIV 402
Query: 258 VSCSSDGGIAVW 269
++ S D +W
Sbjct: 403 ITGSKDNTCRIW 414
Score = 33.1 bits (74), Expect = 0.47
Identities = 11/35 (31%), Positives = 23/35 (65%)
Query: 17 LSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVW 51
++K+EGH+ ++ P+ + ++T S D+T R+W
Sbjct: 338 IAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Score = 31.2 bits (69), Expect = 1.8
Identities = 14/35 (40%), Positives = 20/35 (57%)
Query: 17 LSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVW 51
L +EGH D + + K + VIT S+D T R+W
Sbjct: 380 LQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|31543297 neutral sphingomyelinase (N-SMase) activation
associated factor isoform 1 [Homo sapiens]
Length = 917
Score = 55.8 bits (133), Expect = 7e-08
Identities = 49/216 (22%), Positives = 90/216 (41%), Gaps = 21/216 (9%)
Query: 22 GHQDAVTAALLIPKEDGVITASEDRTIRVW---------LKRDSGQYWPSIYHTMASPCS 72
GH DAV+ + ++ + +AS D T++VW KR + H ++
Sbjct: 712 GHDDAVSK--ICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVS--VD 767
Query: 73 AMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVIST 132
++ + S + G G V + D + P H V FS + V+ST
Sbjct: 768 TISLNAASTLLVSGTKEGTVNIW----DLTTATLMHQIPCHSGIVCDTAFSPDSRHVLST 823
Query: 133 GHDKCVSWMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVI 192
G D C++ + ++G ++ C +D ++ + G SG+ LL + +
Sbjct: 824 GTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVLS--GSQSGE--LLVWDLLGAKIS 879
Query: 193 TTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDI 228
++GH G+V C+W + + +G D II W +
Sbjct: 880 ERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKL 915
Score = 34.3 bits (77), Expect = 0.21
Identities = 62/278 (22%), Positives = 103/278 (37%), Gaps = 54/278 (19%)
Query: 23 HQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRR 82
H++AVT + V T S+D T++++ K +S SI + + S + D+
Sbjct: 629 HKEAVTGITVSRNGSSVFTTSQDSTLKMFSK-ESKMLQRSISFSNMALSSCLLLPGDATV 687
Query: 83 IFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWMC 142
I DN +I F + ++ GHD VS +C
Sbjct: 688 ITSSWDNNVYF------------------------YSIAFGRRQDTLM--GHDDAVSKIC 721
Query: 143 TRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLL-KLEQNTCSVITTLKGHEGS 201
R + SW S ++ G LL +LE H+ S
Sbjct: 722 WHD----NRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELE------------HDVS 765
Query: 202 VACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQ--GHHDKVQSLCYLQLTRQLVS 259
V + + LL SG + ++ +WD+ TL+ Q H V + +R ++S
Sbjct: 766 VDTISLNAASTLLVSGTKEGTVNIWDL---TTATLMHQIPCHSGIVCDTAFSPDSRHVLS 822
Query: 260 CSSDGGIAVWNMDVSREEAPQWLESDSCQKCEQPFFWN 297
+DG + V +DV + SD Q+C F W+
Sbjct: 823 TGTDGCLNV--IDVQTGMLISSMTSDEPQRC---FVWD 855
Score = 28.9 bits (63), Expect = 8.8
Identities = 13/33 (39%), Positives = 18/33 (54%)
Query: 19 KIEGHQDAVTAALLIPKEDGVITASEDRTIRVW 51
+I+GH AVT + + +IT EDR I W
Sbjct: 881 RIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFW 913
>gi|221625547 neutral sphingomyelinase (N-SMase) activation
associated factor isoform 2 [Homo sapiens]
Length = 948
Score = 55.8 bits (133), Expect = 7e-08
Identities = 49/216 (22%), Positives = 90/216 (41%), Gaps = 21/216 (9%)
Query: 22 GHQDAVTAALLIPKEDGVITASEDRTIRVW---------LKRDSGQYWPSIYHTMASPCS 72
GH DAV+ + ++ + +AS D T++VW KR + H ++
Sbjct: 743 GHDDAVSK--ICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVS--VD 798
Query: 73 AMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVIST 132
++ + S + G G V + D + P H V FS + V+ST
Sbjct: 799 TISLNAASTLLVSGTKEGTVNIW----DLTTATLMHQIPCHSGIVCDTAFSPDSRHVLST 854
Query: 133 GHDKCVSWMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVI 192
G D C++ + ++G ++ C +D ++ + G SG+ LL + +
Sbjct: 855 GTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVLS--GSQSGE--LLVWDLLGAKIS 910
Query: 193 TTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDI 228
++GH G+V C+W + + +G D II W +
Sbjct: 911 ERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKL 946
Score = 34.3 bits (77), Expect = 0.21
Identities = 62/278 (22%), Positives = 103/278 (37%), Gaps = 54/278 (19%)
Query: 23 HQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRR 82
H++AVT + V T S+D T++++ K +S SI + + S + D+
Sbjct: 660 HKEAVTGITVSRNGSSVFTTSQDSTLKMFSK-ESKMLQRSISFSNMALSSCLLLPGDATV 718
Query: 83 IFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWMC 142
I DN +I F + ++ GHD VS +C
Sbjct: 719 ITSSWDNNVYF------------------------YSIAFGRRQDTLM--GHDDAVSKIC 752
Query: 143 TRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLL-KLEQNTCSVITTLKGHEGS 201
R + SW S ++ G LL +LE H+ S
Sbjct: 753 WHD----NRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELE------------HDVS 796
Query: 202 VACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQ--GHHDKVQSLCYLQLTRQLVS 259
V + + LL SG + ++ +WD+ TL+ Q H V + +R ++S
Sbjct: 797 VDTISLNAASTLLVSGTKEGTVNIWDL---TTATLMHQIPCHSGIVCDTAFSPDSRHVLS 853
Query: 260 CSSDGGIAVWNMDVSREEAPQWLESDSCQKCEQPFFWN 297
+DG + V +DV + SD Q+C F W+
Sbjct: 854 TGTDGCLNV--IDVQTGMLISSMTSDEPQRC---FVWD 886
Score = 28.9 bits (63), Expect = 8.8
Identities = 13/33 (39%), Positives = 18/33 (54%)
Query: 19 KIEGHQDAVTAALLIPKEDGVITASEDRTIRVW 51
+I+GH AVT + + +IT EDR I W
Sbjct: 912 RIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFW 944
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 55.5 bits (132), Expect = 9e-08
Identities = 67/306 (21%), Positives = 121/306 (39%), Gaps = 28/306 (9%)
Query: 16 LLSKIEGHQDAVTAALLIPK-EDGVITASEDRTIRVW-LKRDSGQYW--PSIYHTMASPC 71
L ++GH VT P+ D +++AS D+TI +W L RD Y +
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66
Query: 72 SAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVIS 131
S + D + G +G + + ++ F+ H V ++ FS ++S
Sbjct: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV----GHTKDVLSVAFSSDNRQIVS 122
Query: 132 TGHDKCVS-WMCTRSGNMLGRHFFT-------SWASCLQYDFDTQYAFVGDYSGQITLLK 183
DK + W N LG +T W SC+++ ++ + +
Sbjct: 123 GSRDKTIKLW------NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176
Query: 184 LEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHD 243
C + T GH G + + P L SG D ++WD+ +G+ L D
Sbjct: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL--NEGKHLYTLDGGD 234
Query: 244 KVQSLCYLQLTRQLVSCSSDGGIAVWNMD--VSREEAPQWLESDSCQKCEQPFFWNIKQM 301
+ +LC+ R + ++ I +W+++ + +E Q + S S K E P ++
Sbjct: 235 IINALCF-SPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTS-SKAEPPQCTSLAWS 292
Query: 302 WDTKTL 307
D +TL
Sbjct: 293 ADGQTL 298
Score = 36.2 bits (82), Expect = 0.055
Identities = 52/224 (23%), Positives = 83/224 (37%), Gaps = 44/224 (19%)
Query: 195 LKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIG-GRKGRTLLLQGHHDKVQSLCYLQL 253
L+GH V+ + + SG+ D ++ +WD+ G R + GH V S+ +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV--GHTKDVLSVAFSSD 116
Query: 254 TRQLVSCSSDGGIAVWN------MDVSREEAPQWLESDSCQK----CEQPFF----WN-I 298
RQ+VS S D I +WN V E +W+ SC + P W+ +
Sbjct: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWV---SCVRFSPNSSNPIIVSCGWDKL 173
Query: 299 KQMWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDEDRTS 358
++W+ L+ +H G S S G + Q + D
Sbjct: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD------------- 220
Query: 359 LATFHEGKHNISHMSMDIARGL-------MVTCGTDRIVKIWDM 395
+EGKH + DI L + T +KIWD+
Sbjct: 221 ---LNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDL 261
Score = 29.6 bits (65), Expect = 5.2
Identities = 16/57 (28%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Query: 172 VGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDI 228
+ D G+I + +L+Q S T+ K L W + LF+G +DN + +W +
Sbjct: 258 IWDLEGKIIVDELKQEVIS--TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 55.1 bits (131), Expect = 1e-07
Identities = 48/164 (29%), Positives = 73/164 (44%), Gaps = 8/164 (4%)
Query: 110 YPAHQNRVSAIIFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWA--SCLQYDFDT 167
Y H V FS + +S GHD+ T L R F A +C ++ ++
Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPL-RIFAGHLADVNCTRFHPNS 639
Query: 168 QYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWD 227
Y G + L + C I T GH+G + L + P R L +GA+D +++WD
Sbjct: 640 NYVATGSADRTVRLWDVLNGNCVRIFT--GHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697
Query: 228 IGGRKGRTL-LLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWN 270
IG G + L+GH D V SL + + L S S D + +W+
Sbjct: 698 IG--HGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 40.4 bits (93), Expect = 0.003
Identities = 49/235 (20%), Positives = 92/235 (39%), Gaps = 35/235 (14%)
Query: 45 DRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKM 104
D T+RVW +P + S + +++ V+E + E
Sbjct: 491 DSTVRVW---------------SVTPKKLRSVKQASDLSLIDKESDDVLERIMDE--KTA 533
Query: 105 NFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVS-WMCTRSGNMLGR--HFFTSWASCL 161
+ +K H V FS +++S+ D V W ++G H + W
Sbjct: 534 SELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVW---- 589
Query: 162 QYDFDTQYAFVGDY---SGQITLLKL-EQNTCSVITTLKGHEGSVACLWWDPIQRLLFSG 217
DTQ++ G Y G + +L + + GH V C + P + +G
Sbjct: 590 ----DTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATG 645
Query: 218 ASDNSIIMWDI-GGRKGRTLLLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNM 271
++D ++ +WD+ G R + GH + SL + R L + ++DG + +W++
Sbjct: 646 SADRTVRLWDVLNGNCVR--IFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI 698
>gi|31317270 WD repeat and FYVE domain containing 3 isoform 3 [Homo
sapiens]
Length = 281
Score = 55.1 bits (131), Expect = 1e-07
Identities = 32/98 (32%), Positives = 45/98 (45%), Gaps = 16/98 (16%)
Query: 262 SDGGIAVWNMD--VSREEAPQWLES---DSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRK 316
S G + W++ R A W++ DSC C F +L R+HHCR
Sbjct: 185 SRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRF-----------SLTERRHHCRN 233
Query: 317 CGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDE 354
CGQ C KCS +S + VRVC +CY +++ E
Sbjct: 234 CGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHE 271
>gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 3526
Score = 55.1 bits (131), Expect = 1e-07
Identities = 32/98 (32%), Positives = 45/98 (45%), Gaps = 16/98 (16%)
Query: 262 SDGGIAVWNMD--VSREEAPQWLES---DSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRK 316
S G + W++ R A W++ DSC C F +L R+HHCR
Sbjct: 3430 SRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRF-----------SLTERRHHCRN 3478
Query: 317 CGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDE 354
CGQ C KCS +S + VRVC +CY +++ E
Sbjct: 3479 CGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHE 3516
Score = 46.6 bits (109), Expect = 4e-05
Identities = 28/90 (31%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 183 KLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHH 242
K + T ++ L GH +V C ++ SG+ D + I+WD+ T L+GH
Sbjct: 3111 KEKAKTVTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLT-QLRGHR 3169
Query: 243 DKVQSLCYLQLTRQLVSCSSDGGIAVWNMD 272
V +LC +LT +VSC+ I VW+++
Sbjct: 3170 APVSALCINELTGDIVSCAGT-YIHVWSIN 3198
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 54.3 bits (129), Expect = 2e-07
Identities = 67/272 (24%), Positives = 106/272 (38%), Gaps = 32/272 (11%)
Query: 17 LSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAY 76
L+ H V AAL + ++TA ED ++VW G+ + SP ++A
Sbjct: 1877 LAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVW-SGSLGRPRGHLGSLSLSPALSVAL 1935
Query: 77 HHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDK 136
D R+ VG + + +S A VSA+ + L+ + ++S D
Sbjct: 1936 SPDGDRVAVGYRADGIRIYKISSGSQGAQG----QALDVAVSALAW-LSPKVLVSGAEDG 1990
Query: 137 CVS------------WMCTRSGN-MLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLL- 182
+ W+ +R +LG + DF Q + Q+
Sbjct: 1991 SLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQL-----WPRQLLTRP 2045
Query: 183 -KLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQ-- 239
K E C T L+GHEG V+C + L +G D S++ WD+ K L+
Sbjct: 2046 HKAEDFPCG--TELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFP 2103
Query: 240 -GHHDKVQSLCYLQLTRQLVSCSSDGGIAVWN 270
H D V C L+SCSSDG + +W+
Sbjct: 2104 ACHRDWVTG-CAWTKDNLLISCSSDGSVGLWD 2134
Score = 42.4 bits (98), Expect = 8e-04
Identities = 34/165 (20%), Positives = 69/165 (41%), Gaps = 5/165 (3%)
Query: 112 AHQNRVSAIIFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWASCLQYDFDTQYAF 171
AHQ +++ S + + C+ T G + +H + +C+ + + Q
Sbjct: 1757 AHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVIA 1816
Query: 172 VGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGR 231
G ++G I+ +++ V L S+ L ++ ++ G D+ + +W R
Sbjct: 1817 TGSWAGSISFFQVDG--LKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELW--AWR 1872
Query: 232 KG-RTLLLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVSR 275
+G R HH V + +L QL++ DG + VW+ + R
Sbjct: 1873 EGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGR 1917
Score = 28.9 bits (63), Expect = 8.8
Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 9/119 (7%)
Query: 22 GHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSR 81
GH V AA + ++TASED ++R+W + ++ +A+A+ D
Sbjct: 2236 GHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEAD--DTCIPRSSAAVTAVAWAPDGS 2293
Query: 82 RIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSW 140
G G ++ + + K P H + A+I+S A + + + +K W
Sbjct: 2294 MAVSGNQAGELILWQEA----KAVATAQAPGH---IGALIWSSAHTFFVLSADEKISEW 2345
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 53.9 bits (128), Expect = 3e-07
Identities = 27/79 (34%), Positives = 38/79 (48%), Gaps = 14/79 (17%)
Query: 276 EEAPQWLESDS---CQKCEQPFFWNIKQMWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSY 332
+ AP+W+ + C KC++PF L R+HHCR CG VC KCS ++
Sbjct: 551 KRAPRWIRDNEVTMCMKCKEPF----------NALTRRRHHCRACGYVVCWKCSDYKAQL 600
Query: 333 PVMGFEFQVRVCDSCYDSI 351
G + +VC CY I
Sbjct: 601 EYDGGKLS-KVCKDCYQII 618
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.134 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,130,811
Number of Sequences: 37866
Number of extensions: 689401
Number of successful extensions: 3903
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 199
Number of HSP's successfully gapped in prelim test: 131
Number of HSP's that attempted gapping in prelim test: 2185
Number of HSP's gapped (non-prelim): 1396
length of query: 410
length of database: 18,247,518
effective HSP length: 105
effective length of query: 305
effective length of database: 14,271,588
effective search space: 4352834340
effective search space used: 4352834340
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.