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Search of human proteins with 18254474
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18254474 ankyrin repeat and SOCS box-containing protein 11
isoform a [Homo sapiens]
(323 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18254474 ankyrin repeat and SOCS box-containing protein 11 is... 654 0.0
gi|60218887 ankyrin repeat and SOCS box-containing protein 11 is... 535 e-152
gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Ho... 350 1e-96
gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1 [... 290 2e-78
gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2 [... 245 3e-65
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 197 1e-50
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 102 5e-22
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 102 5e-22
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 102 5e-22
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 102 5e-22
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 102 5e-22
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 99 5e-21
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 99 5e-21
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 99 5e-21
gi|94721248 ankyrin repeat and SOCS box-containing protein 1 [Ho... 99 7e-21
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 98 9e-21
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 98 9e-21
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 96 3e-20
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 96 3e-20
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 96 3e-20
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 96 3e-20
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 96 3e-20
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 95 1e-19
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 94 2e-19
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 92 8e-19
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 91 1e-18
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 91 2e-18
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso... 89 4e-18
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 89 5e-18
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 88 9e-18
>gi|18254474 ankyrin repeat and SOCS box-containing protein 11
isoform a [Homo sapiens]
Length = 323
Score = 654 bits (1687), Expect = 0.0
Identities = 323/323 (100%), Positives = 323/323 (100%)
Query: 1 MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGIS 60
MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGIS
Sbjct: 1 MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGIS 60
Query: 61 DCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN 120
DCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN
Sbjct: 61 DCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN 120
Query: 121 GAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME 180
GAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME
Sbjct: 121 GAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME 180
Query: 181 ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSN 240
ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSN
Sbjct: 181 ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSN 240
Query: 241 VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLG 300
VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLG
Sbjct: 241 VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLG 300
Query: 301 RACHQAIHKLHLPEPLERFLLYQ 323
RACHQAIHKLHLPEPLERFLLYQ
Sbjct: 301 RACHQAIHKLHLPEPLERFLLYQ 323
>gi|60218887 ankyrin repeat and SOCS box-containing protein 11
isoform b [Homo sapiens]
Length = 302
Score = 535 bits (1379), Expect = e-152
Identities = 263/263 (100%), Positives = 263/263 (100%)
Query: 61 DCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN 120
DCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN
Sbjct: 40 DCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN 99
Query: 121 GAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME 180
GAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME
Sbjct: 100 GAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME 159
Query: 181 ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSN 240
ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSN
Sbjct: 160 ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSN 219
Query: 241 VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLG 300
VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLG
Sbjct: 220 VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLG 279
Query: 301 RACHQAIHKLHLPEPLERFLLYQ 323
RACHQAIHKLHLPEPLERFLLYQ
Sbjct: 280 RACHQAIHKLHLPEPLERFLLYQ 302
>gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Homo
sapiens]
Length = 329
Score = 350 bits (898), Expect = 1e-96
Identities = 175/325 (53%), Positives = 232/325 (71%), Gaps = 4/325 (1%)
Query: 2 EDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISD 61
E+ P N++ T+ + F FKL +K+ LA+L+HFYIVKGNRKEAARIA E YG
Sbjct: 6 ENRPFAQQLSNVYFTILS-LFCFKLFVKISLAILSHFYIVKGNRKEAARIAAEFYGVTQG 64
Query: 62 --CWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLE 119
WADRSPLHEAA+QGRLLAL+TL++QG NVN VT++ V+ LHEACLG HVACA+ LLE
Sbjct: 65 QGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLE 124
Query: 120 NGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECM 179
GA+VN +T+ G TPLFNAC GS +C +LLE+GAKAQLE L SP HEA +GH EC+
Sbjct: 125 AGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECL 184
Query: 180 EILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQS 239
+IL++ +++D E+P LGTPLYVAC Q+ C+ KLL GA V G++ DTPLHAAA+QS
Sbjct: 185 DILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQS 244
Query: 240 NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREG-PPALSQLCRLCVRKC 298
+ E+++LL ++GA++ +N + +D+A S VE+ LL E P +L QLCRLC+R
Sbjct: 245 STEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLCIRSY 304
Query: 299 LGRACHQAIHKLHLPEPLERFLLYQ 323
+G+ I +L LP L+ FL Y+
Sbjct: 305 IGKPRLHLIPQLQLPTLLKNFLQYR 329
>gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1
[Homo sapiens]
Length = 294
Score = 290 bits (741), Expect = 2e-78
Identities = 146/264 (55%), Positives = 188/264 (71%)
Query: 59 ISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALL 118
+ D +D SP+HEAA G L+L+ LI+QG VN++T + VS LHEACLGGH++C K LL
Sbjct: 30 MGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILL 89
Query: 119 ENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHREC 178
++GA VNGVT TPLFNAC SGS CVN+LL+ GA Q E LASPIHEA +RGH EC
Sbjct: 90 KHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVEC 149
Query: 179 MEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQ 238
+ L+A NIDH++ LGTPLY+AC Q+ CVKKLLE GA V+ G+ D+PLHA AR
Sbjct: 150 VNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVART 209
Query: 239 SNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKC 298
++ E+ LL D+GA+ + +NA+GK ++L P+S + Q L REGPP+L QLCRL +RKC
Sbjct: 210 ASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREGPPSLMQLCRLRIRKC 269
Query: 299 LGRACHQAIHKLHLPEPLERFLLY 322
G H I KL LPE L++FLL+
Sbjct: 270 FGIQQHHKITKLVLPEDLKQFLLH 293
>gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2
[Homo sapiens]
Length = 262
Score = 245 bits (626), Expect = 3e-65
Identities = 123/225 (54%), Positives = 160/225 (71%)
Query: 59 ISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALL 118
+ D +D SP+HEAA G L+L+ LI+QG VN++T + VS LHEACLGGH++C K LL
Sbjct: 30 MGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILL 89
Query: 119 ENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHREC 178
++GA VNGVT TPLFNAC SGS CVN+LL+ GA Q E LASPIHEA +RGH EC
Sbjct: 90 KHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVEC 149
Query: 179 MEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQ 238
+ L+A NIDH++ LGTPLY+AC Q+ CVKKLLE GA V+ G+ D+PLHA AR
Sbjct: 150 VNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVART 209
Query: 239 SNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREG 283
++ E+ LL D+GA+ + +NA+GK ++L P+S + Q L REG
Sbjct: 210 ASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREG 254
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 197 bits (501), Expect = 1e-50
Identities = 108/274 (39%), Positives = 158/274 (57%), Gaps = 1/274 (0%)
Query: 50 RIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGG 109
R A+ + G W +R+P+HEAA +G L L+ LI G VN VT++ ++ LH A L G
Sbjct: 4 RAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQG 63
Query: 110 HVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHE 169
C + LL GA V+ + G+TPL +AC SGS CV +LL +GAK ++ ASP+HE
Sbjct: 64 QARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHE 123
Query: 170 AVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD 229
A G EC+ +L+ N++ GTPL+VAC + +DCVK LL GA+V+ + +
Sbjct: 124 ACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE 183
Query: 230 TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPP-ALS 288
T LH AA+ NV++I +L ++G N+ R+ +GK D S+ + E P LS
Sbjct: 184 TALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLS 243
Query: 289 QLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLY 322
QLCR+ +RK G + I KL++P L +L Y
Sbjct: 244 QLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSY 277
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 102 bits (254), Expect = 5e-22
Identities = 79/249 (31%), Positives = 107/249 (42%), Gaps = 35/249 (14%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A+ G L +K L+ +G + N+ + + LH A GH AK LL+N A VN
Sbjct: 439 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 498
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-------EVHLA--------------- 164
TPL A G V +LLE A L +H+A
Sbjct: 499 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 558
Query: 165 ------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 212
+P+H A K G E+LL + + + TPL+VA + +D V
Sbjct: 559 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 618
Query: 213 KKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 271
K LL G S W TPLH AA+Q+ VEV L YG + + QG + L LAA +
Sbjct: 619 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 678
Query: 272 SSVEQALLL 280
E LL
Sbjct: 679 GHAEMVALL 687
Score = 97.4 bits (241), Expect = 1e-20
Identities = 61/216 (28%), Positives = 109/216 (50%), Gaps = 2/216 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A+ +G ++ ++ L+ +G + T + ++ LH A GHV ++ LL++GA +
Sbjct: 274 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLAN 185
T +G +P+ A CV +LL++ A+ + + +P+H A GH ++LL
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
+ TPL++AC V ++ LL+ GAS+D TPLH A+ ++ ++
Sbjct: 394 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
L GA+ N + ++ L +AA E A L
Sbjct: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/219 (32%), Positives = 106/219 (48%), Gaps = 5/219 (2%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 128
LH AA G+ ++ L+ G NVN + + L+ A H+ K LLENGA+ N T
Sbjct: 115 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 174
Query: 129 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 188
G TPL A G V L+ +G K ++ + +H A + +LL N+ N
Sbjct: 175 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQNDPN 231
Query: 189 IDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLL 247
D TPL++A Y+ ++ + LL GASV+ Q TPLH A+R+ NV ++ LL
Sbjct: 232 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 291
Query: 248 TDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREGPP 285
D GA ++ + + L AA V +LL G P
Sbjct: 292 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 330
Score = 94.4 bits (233), Expect = 1e-19
Identities = 79/250 (31%), Positives = 121/250 (48%), Gaps = 10/250 (4%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA L + L+ +G +VN N ++ LH A G+V + LL+ GA +
Sbjct: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 300
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 185
T TPL A +G +LL+ GA Q + + SPIH A + H +C+ +LL
Sbjct: 301 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 360
Query: 186 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+ ID TPL+VA C + RV K LL+ GA + + L+ TPLH A ++++V
Sbjct: 361 DAEIDDITLDHLTPLHVAAHCGHHRV--AKVLLDKGAK-PNSRALNGFTPLHIACKKNHV 417
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAA--PKSSVEQALLLREGPPALSQLCRLCVRKCL 299
V+ LL GA++ G + L +A+ + + LL R P +S +
Sbjct: 418 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 477
Query: 300 GRACHQAIHK 309
RA H + K
Sbjct: 478 ARAGHTEVAK 487
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/223 (30%), Positives = 107/223 (47%), Gaps = 4/223 (1%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A + + ++ L+ G +++ VT + ++ LH A GH+ K LL+ GA N
Sbjct: 406 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 185
V TPL A +G LL+ AK + +P+H A + GH +++LL N
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 525
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS-VDHGQWLDTPLHAAARQSNVEVI 244
N N + TPL++A V+ V LLE AS + TPLH AA+ V V
Sbjct: 526 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 585
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE--QALLLREGPP 285
LL + A+ G + L +A ++++ + LL R G P
Sbjct: 586 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 2/204 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A L +K L+ +G + + N + LH A V A++LL+ G N
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 663
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
+V G TPL A G A V +LL A L +P+H + GH ++L+ +
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
V +D TPL+VA Y + VK LL+ A V+ L +PLH AA+Q + +++
Sbjct: 724 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 783
Query: 245 HLLTDYGANLKRRNAQGKSALDLA 268
LL GA+ ++ G + L +A
Sbjct: 784 TLLLKNGASPNEVSSDGTTPLAIA 807
Score = 82.8 bits (203), Expect = 4e-16
Identities = 61/220 (27%), Positives = 100/220 (45%), Gaps = 3/220 (1%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA G++ + L+ + + N N ++ LH A ++ K LL G +
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-VHLASPIHEAVKRGHRECMEILLAN 185
+G TPL A LL++G A E V +P+H A + GH E + +LL+
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 690
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
N + TPL++ V L++ G VD + TPLH A+ N++++
Sbjct: 691 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 750
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 283
L + A++ + G S L AA + + LLL+ G
Sbjct: 751 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 790
Score = 75.1 bits (183), Expect = 8e-14
Identities = 78/283 (27%), Positives = 113/283 (39%), Gaps = 67/283 (23%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVT----------------------IN------- 97
+PL+ AA + L +K L+ G N N+ T IN
Sbjct: 146 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 205
Query: 98 RVSSLHEACLGGHVACAKALLEN---------------------------------GAHV 124
R+ +LH A A LL+N GA V
Sbjct: 206 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 265
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILL 183
N +G TPL A G+ V +LL+ GA+ + + +P+H A + GH EILL
Sbjct: 266 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 325
Query: 184 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+ I + +P+++A +DCV+ LL+ A +D LD TPLH AA +
Sbjct: 326 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHH 384
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 283
V +L D GA R G + L +A K+ V LLL+ G
Sbjct: 385 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 427
Score = 72.8 bits (177), Expect = 4e-13
Identities = 52/165 (31%), Positives = 84/165 (50%), Gaps = 4/165 (2%)
Query: 42 KGNRKEAARIAEEIYGGISDCWADR--SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRV 99
K N+ E AR + YGG ++ + + +PLH AA +G + L+++ N NL + +
Sbjct: 644 KQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702
Query: 100 SSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL 159
+ LH GHV A L+++G V+ T G TPL A G+ V LL+ A
Sbjct: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762
Query: 160 EVHLA-SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVA 203
+ L SP+H+A ++GH + + +LL N + + TPL +A
Sbjct: 763 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
Score = 63.2 bits (152), Expect = 3e-10
Identities = 57/210 (27%), Positives = 84/210 (40%), Gaps = 4/210 (1%)
Query: 72 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 131
AA G L + GV++N N ++ LH A GHV LL + T G
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
Query: 132 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 190
T L A +G V L+ +GA + +P++ A + H E ++ LL N N +
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 171
Query: 191 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDY 250
TPL VA + V L+ G G+ LH AAR + +L
Sbjct: 172 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 228
Query: 251 GANLKRRNAQGKSALDLAAPKSSVEQALLL 280
N + G + L +AA ++ A LL
Sbjct: 229 DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 258
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A +G + LI GV V+ T + LH A G++ K LL++ A VN
Sbjct: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEIL 182
T G +PL A G V +LL+ GA ++ +P+ A + G+ ++L
Sbjct: 763 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 35.4 bits (80), Expect = 0.069
Identities = 19/54 (35%), Positives = 31/54 (57%)
Query: 229 DTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 282
+T LH AA EV+ L +YGAN+ ++ +G + L +AA ++ +E L E
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 102 bits (254), Expect = 5e-22
Identities = 79/249 (31%), Positives = 107/249 (42%), Gaps = 35/249 (14%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A+ G L +K L+ +G + N+ + + LH A GH AK LL+N A VN
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-------EVHLA--------------- 164
TPL A G V +LLE A L +H+A
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Query: 165 ------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 212
+P+H A K G E+LL + + + TPL+VA + +D V
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585
Query: 213 KKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 271
K LL G S W TPLH AA+Q+ VEV L YG + + QG + L LAA +
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Query: 272 SSVEQALLL 280
E LL
Sbjct: 646 GHAEMVALL 654
Score = 97.4 bits (241), Expect = 1e-20
Identities = 61/216 (28%), Positives = 109/216 (50%), Gaps = 2/216 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A+ +G ++ ++ L+ +G + T + ++ LH A GHV ++ LL++GA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLAN 185
T +G +P+ A CV +LL++ A+ + + +P+H A GH ++LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
+ TPL++AC V ++ LL+ GAS+D TPLH A+ ++ ++
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
L GA+ N + ++ L +AA E A L
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/219 (32%), Positives = 106/219 (48%), Gaps = 5/219 (2%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 128
LH AA G+ ++ L+ G NVN + + L+ A H+ K LLENGA+ N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 129 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 188
G TPL A G V L+ +G K ++ + +H A + +LL N+ N
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQNDPN 198
Query: 189 IDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLL 247
D TPL++A Y+ ++ + LL GASV+ Q TPLH A+R+ NV ++ LL
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 248 TDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREGPP 285
D GA ++ + + L AA V +LL G P
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 94.4 bits (233), Expect = 1e-19
Identities = 79/250 (31%), Positives = 121/250 (48%), Gaps = 10/250 (4%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA L + L+ +G +VN N ++ LH A G+V + LL+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 185
T TPL A +G +LL+ GA Q + + SPIH A + H +C+ +LL
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 186 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+ ID TPL+VA C + RV K LL+ GA + + L+ TPLH A ++++V
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRV--AKVLLDKGAK-PNSRALNGFTPLHIACKKNHV 384
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAA--PKSSVEQALLLREGPPALSQLCRLCVRKCL 299
V+ LL GA++ G + L +A+ + + LL R P +S +
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Query: 300 GRACHQAIHK 309
RA H + K
Sbjct: 445 ARAGHTEVAK 454
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/223 (30%), Positives = 107/223 (47%), Gaps = 4/223 (1%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A + + ++ L+ G +++ VT + ++ LH A GH+ K LL+ GA N
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 185
V TPL A +G LL+ AK + +P+H A + GH +++LL N
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS-VDHGQWLDTPLHAAARQSNVEVI 244
N N + TPL++A V+ V LLE AS + TPLH AA+ V V
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE--QALLLREGPP 285
LL + A+ G + L +A ++++ + LL R G P
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 2/204 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A L +K L+ +G + + N + LH A V A++LL+ G N
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
+V G TPL A G A V +LL A L +P+H + GH ++L+ +
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
V +D TPL+VA Y + VK LL+ A V+ L +PLH AA+Q + +++
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 245 HLLTDYGANLKRRNAQGKSALDLA 268
LL GA+ ++ G + L +A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774
Score = 82.8 bits (203), Expect = 4e-16
Identities = 61/220 (27%), Positives = 100/220 (45%), Gaps = 3/220 (1%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA G++ + L+ + + N N ++ LH A ++ K LL G +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-VHLASPIHEAVKRGHRECMEILLAN 185
+G TPL A LL++G A E V +P+H A + GH E + +LL+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
N + TPL++ V L++ G VD + TPLH A+ N++++
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 283
L + A++ + G S L AA + + LLL+ G
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Score = 75.1 bits (183), Expect = 8e-14
Identities = 78/283 (27%), Positives = 113/283 (39%), Gaps = 67/283 (23%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVT----------------------IN------- 97
+PL+ AA + L +K L+ G N N+ T IN
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 98 RVSSLHEACLGGHVACAKALLEN---------------------------------GAHV 124
R+ +LH A A LL+N GA V
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILL 183
N +G TPL A G+ V +LL+ GA+ + + +P+H A + GH EILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 184 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+ I + +P+++A +DCV+ LL+ A +D LD TPLH AA +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHH 351
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 283
V +L D GA R G + L +A K+ V LLL+ G
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Score = 72.8 bits (177), Expect = 4e-13
Identities = 52/165 (31%), Positives = 84/165 (50%), Gaps = 4/165 (2%)
Query: 42 KGNRKEAARIAEEIYGGISDCWADR--SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRV 99
K N+ E AR + YGG ++ + + +PLH AA +G + L+++ N NL + +
Sbjct: 611 KQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 100 SSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL 159
+ LH GHV A L+++G V+ T G TPL A G+ V LL+ A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 160 EVHLA-SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVA 203
+ L SP+H+A ++GH + + +LL N + + TPL +A
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 63.2 bits (152), Expect = 3e-10
Identities = 57/210 (27%), Positives = 84/210 (40%), Gaps = 4/210 (1%)
Query: 72 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 131
AA G L + GV++N N ++ LH A GHV LL + T G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 132 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 190
T L A +G V L+ +GA + +P++ A + H E ++ LL N N +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 191 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDY 250
TPL VA + V L+ G G+ LH AAR + +L
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 251 GANLKRRNAQGKSALDLAAPKSSVEQALLL 280
N + G + L +AA ++ A LL
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 225
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A +G + LI GV V+ T + LH A G++ K LL++ A VN
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEIL 182
T G +PL A G V +LL+ GA ++ +P+ A + G+ ++L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 35.4 bits (80), Expect = 0.069
Identities = 19/54 (35%), Positives = 31/54 (57%)
Query: 229 DTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 282
+T LH AA EV+ L +YGAN+ ++ +G + L +AA ++ +E L E
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 102 bits (254), Expect = 5e-22
Identities = 79/249 (31%), Positives = 107/249 (42%), Gaps = 35/249 (14%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A+ G L +K L+ +G + N+ + + LH A GH AK LL+N A VN
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-------EVHLA--------------- 164
TPL A G V +LLE A L +H+A
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Query: 165 ------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 212
+P+H A K G E+LL + + + TPL+VA + +D V
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585
Query: 213 KKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 271
K LL G S W TPLH AA+Q+ VEV L YG + + QG + L LAA +
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Query: 272 SSVEQALLL 280
E LL
Sbjct: 646 GHAEMVALL 654
Score = 97.4 bits (241), Expect = 1e-20
Identities = 61/216 (28%), Positives = 109/216 (50%), Gaps = 2/216 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A+ +G ++ ++ L+ +G + T + ++ LH A GHV ++ LL++GA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLAN 185
T +G +P+ A CV +LL++ A+ + + +P+H A GH ++LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
+ TPL++AC V ++ LL+ GAS+D TPLH A+ ++ ++
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
L GA+ N + ++ L +AA E A L
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/219 (32%), Positives = 106/219 (48%), Gaps = 5/219 (2%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 128
LH AA G+ ++ L+ G NVN + + L+ A H+ K LLENGA+ N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 129 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 188
G TPL A G V L+ +G K ++ + +H A + +LL N+ N
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQNDPN 198
Query: 189 IDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLL 247
D TPL++A Y+ ++ + LL GASV+ Q TPLH A+R+ NV ++ LL
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 248 TDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREGPP 285
D GA ++ + + L AA V +LL G P
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 94.4 bits (233), Expect = 1e-19
Identities = 79/250 (31%), Positives = 121/250 (48%), Gaps = 10/250 (4%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA L + L+ +G +VN N ++ LH A G+V + LL+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 185
T TPL A +G +LL+ GA Q + + SPIH A + H +C+ +LL
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 186 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+ ID TPL+VA C + RV K LL+ GA + + L+ TPLH A ++++V
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRV--AKVLLDKGAK-PNSRALNGFTPLHIACKKNHV 384
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAA--PKSSVEQALLLREGPPALSQLCRLCVRKCL 299
V+ LL GA++ G + L +A+ + + LL R P +S +
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Query: 300 GRACHQAIHK 309
RA H + K
Sbjct: 445 ARAGHTEVAK 454
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/223 (30%), Positives = 107/223 (47%), Gaps = 4/223 (1%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A + + ++ L+ G +++ VT + ++ LH A GH+ K LL+ GA N
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 185
V TPL A +G LL+ AK + +P+H A + GH +++LL N
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS-VDHGQWLDTPLHAAARQSNVEVI 244
N N + TPL++A V+ V LLE AS + TPLH AA+ V V
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE--QALLLREGPP 285
LL + A+ G + L +A ++++ + LL R G P
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 2/204 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A L +K L+ +G + + N + LH A V A++LL+ G N
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
+V G TPL A G A V +LL A L +P+H + GH ++L+ +
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
V +D TPL+VA Y + VK LL+ A V+ L +PLH AA+Q + +++
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 245 HLLTDYGANLKRRNAQGKSALDLA 268
LL GA+ ++ G + L +A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774
Score = 82.8 bits (203), Expect = 4e-16
Identities = 61/220 (27%), Positives = 100/220 (45%), Gaps = 3/220 (1%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA G++ + L+ + + N N ++ LH A ++ K LL G +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-VHLASPIHEAVKRGHRECMEILLAN 185
+G TPL A LL++G A E V +P+H A + GH E + +LL+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
N + TPL++ V L++ G VD + TPLH A+ N++++
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 283
L + A++ + G S L AA + + LLL+ G
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Score = 75.1 bits (183), Expect = 8e-14
Identities = 78/283 (27%), Positives = 113/283 (39%), Gaps = 67/283 (23%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVT----------------------IN------- 97
+PL+ AA + L +K L+ G N N+ T IN
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 98 RVSSLHEACLGGHVACAKALLEN---------------------------------GAHV 124
R+ +LH A A LL+N GA V
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILL 183
N +G TPL A G+ V +LL+ GA+ + + +P+H A + GH EILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 184 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+ I + +P+++A +DCV+ LL+ A +D LD TPLH AA +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHH 351
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 283
V +L D GA R G + L +A K+ V LLL+ G
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Score = 72.8 bits (177), Expect = 4e-13
Identities = 52/165 (31%), Positives = 84/165 (50%), Gaps = 4/165 (2%)
Query: 42 KGNRKEAARIAEEIYGGISDCWADR--SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRV 99
K N+ E AR + YGG ++ + + +PLH AA +G + L+++ N NL + +
Sbjct: 611 KQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 100 SSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL 159
+ LH GHV A L+++G V+ T G TPL A G+ V LL+ A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 160 EVHLA-SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVA 203
+ L SP+H+A ++GH + + +LL N + + TPL +A
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 63.2 bits (152), Expect = 3e-10
Identities = 57/210 (27%), Positives = 84/210 (40%), Gaps = 4/210 (1%)
Query: 72 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 131
AA G L + GV++N N ++ LH A GHV LL + T G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 132 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 190
T L A +G V L+ +GA + +P++ A + H E ++ LL N N +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 191 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDY 250
TPL VA + V L+ G G+ LH AAR + +L
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 251 GANLKRRNAQGKSALDLAAPKSSVEQALLL 280
N + G + L +AA ++ A LL
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 225
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A +G + LI GV V+ T + LH A G++ K LL++ A VN
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEIL 182
T G +PL A G V +LL+ GA ++ +P+ A + G+ ++L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 35.4 bits (80), Expect = 0.069
Identities = 19/54 (35%), Positives = 31/54 (57%)
Query: 229 DTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 282
+T LH AA EV+ L +YGAN+ ++ +G + L +AA ++ +E L E
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 102 bits (254), Expect = 5e-22
Identities = 79/249 (31%), Positives = 107/249 (42%), Gaps = 35/249 (14%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A+ G L +K L+ +G + N+ + + LH A GH AK LL+N A VN
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-------EVHLA--------------- 164
TPL A G V +LLE A L +H+A
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Query: 165 ------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 212
+P+H A K G E+LL + + + TPL+VA + +D V
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585
Query: 213 KKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 271
K LL G S W TPLH AA+Q+ VEV L YG + + QG + L LAA +
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Query: 272 SSVEQALLL 280
E LL
Sbjct: 646 GHAEMVALL 654
Score = 97.4 bits (241), Expect = 1e-20
Identities = 61/216 (28%), Positives = 109/216 (50%), Gaps = 2/216 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A+ +G ++ ++ L+ +G + T + ++ LH A GHV ++ LL++GA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLAN 185
T +G +P+ A CV +LL++ A+ + + +P+H A GH ++LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
+ TPL++AC V ++ LL+ GAS+D TPLH A+ ++ ++
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
L GA+ N + ++ L +AA E A L
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/219 (32%), Positives = 106/219 (48%), Gaps = 5/219 (2%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 128
LH AA G+ ++ L+ G NVN + + L+ A H+ K LLENGA+ N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 129 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 188
G TPL A G V L+ +G K ++ + +H A + +LL N+ N
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQNDPN 198
Query: 189 IDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLL 247
D TPL++A Y+ ++ + LL GASV+ Q TPLH A+R+ NV ++ LL
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 248 TDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREGPP 285
D GA ++ + + L AA V +LL G P
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 94.4 bits (233), Expect = 1e-19
Identities = 79/250 (31%), Positives = 121/250 (48%), Gaps = 10/250 (4%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA L + L+ +G +VN N ++ LH A G+V + LL+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 185
T TPL A +G +LL+ GA Q + + SPIH A + H +C+ +LL
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 186 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+ ID TPL+VA C + RV K LL+ GA + + L+ TPLH A ++++V
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRV--AKVLLDKGAK-PNSRALNGFTPLHIACKKNHV 384
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAA--PKSSVEQALLLREGPPALSQLCRLCVRKCL 299
V+ LL GA++ G + L +A+ + + LL R P +S +
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Query: 300 GRACHQAIHK 309
RA H + K
Sbjct: 445 ARAGHTEVAK 454
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/223 (30%), Positives = 107/223 (47%), Gaps = 4/223 (1%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A + + ++ L+ G +++ VT + ++ LH A GH+ K LL+ GA N
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 185
V TPL A +G LL+ AK + +P+H A + GH +++LL N
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS-VDHGQWLDTPLHAAARQSNVEVI 244
N N + TPL++A V+ V LLE AS + TPLH AA+ V V
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE--QALLLREGPP 285
LL + A+ G + L +A ++++ + LL R G P
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 2/204 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A L +K L+ +G + + N + LH A V A++LL+ G N
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
+V G TPL A G A V +LL A L +P+H + GH ++L+ +
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
V +D TPL+VA Y + VK LL+ A V+ L +PLH AA+Q + +++
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 245 HLLTDYGANLKRRNAQGKSALDLA 268
LL GA+ ++ G + L +A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774
Score = 82.8 bits (203), Expect = 4e-16
Identities = 61/220 (27%), Positives = 100/220 (45%), Gaps = 3/220 (1%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA G++ + L+ + + N N ++ LH A ++ K LL G +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-VHLASPIHEAVKRGHRECMEILLAN 185
+G TPL A LL++G A E V +P+H A + GH E + +LL+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
N + TPL++ V L++ G VD + TPLH A+ N++++
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 283
L + A++ + G S L AA + + LLL+ G
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Score = 75.1 bits (183), Expect = 8e-14
Identities = 78/283 (27%), Positives = 113/283 (39%), Gaps = 67/283 (23%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVT----------------------IN------- 97
+PL+ AA + L +K L+ G N N+ T IN
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 98 RVSSLHEACLGGHVACAKALLEN---------------------------------GAHV 124
R+ +LH A A LL+N GA V
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILL 183
N +G TPL A G+ V +LL+ GA+ + + +P+H A + GH EILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 184 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+ I + +P+++A +DCV+ LL+ A +D LD TPLH AA +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHH 351
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 283
V +L D GA R G + L +A K+ V LLL+ G
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Score = 72.8 bits (177), Expect = 4e-13
Identities = 52/165 (31%), Positives = 84/165 (50%), Gaps = 4/165 (2%)
Query: 42 KGNRKEAARIAEEIYGGISDCWADR--SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRV 99
K N+ E AR + YGG ++ + + +PLH AA +G + L+++ N NL + +
Sbjct: 611 KQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 100 SSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL 159
+ LH GHV A L+++G V+ T G TPL A G+ V LL+ A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 160 EVHLA-SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVA 203
+ L SP+H+A ++GH + + +LL N + + TPL +A
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 63.2 bits (152), Expect = 3e-10
Identities = 57/210 (27%), Positives = 84/210 (40%), Gaps = 4/210 (1%)
Query: 72 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 131
AA G L + GV++N N ++ LH A GHV LL + T G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 132 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 190
T L A +G V L+ +GA + +P++ A + H E ++ LL N N +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 191 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDY 250
TPL VA + V L+ G G+ LH AAR + +L
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 251 GANLKRRNAQGKSALDLAAPKSSVEQALLL 280
N + G + L +AA ++ A LL
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 225
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A +G + LI GV V+ T + LH A G++ K LL++ A VN
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEIL 182
T G +PL A G V +LL+ GA ++ +P+ A + G+ ++L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 35.4 bits (80), Expect = 0.069
Identities = 19/54 (35%), Positives = 31/54 (57%)
Query: 229 DTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 282
+T LH AA EV+ L +YGAN+ ++ +G + L +AA ++ +E L E
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 102 bits (254), Expect = 5e-22
Identities = 79/249 (31%), Positives = 107/249 (42%), Gaps = 35/249 (14%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A+ G L +K L+ +G + N+ + + LH A GH AK LL+N A VN
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-------EVHLA--------------- 164
TPL A G V +LLE A L +H+A
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Query: 165 ------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 212
+P+H A K G E+LL + + + TPL+VA + +D V
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585
Query: 213 KKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 271
K LL G S W TPLH AA+Q+ VEV L YG + + QG + L LAA +
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Query: 272 SSVEQALLL 280
E LL
Sbjct: 646 GHAEMVALL 654
Score = 97.4 bits (241), Expect = 1e-20
Identities = 61/216 (28%), Positives = 109/216 (50%), Gaps = 2/216 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A+ +G ++ ++ L+ +G + T + ++ LH A GHV ++ LL++GA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLAN 185
T +G +P+ A CV +LL++ A+ + + +P+H A GH ++LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
+ TPL++AC V ++ LL+ GAS+D TPLH A+ ++ ++
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
L GA+ N + ++ L +AA E A L
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/219 (32%), Positives = 106/219 (48%), Gaps = 5/219 (2%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 128
LH AA G+ ++ L+ G NVN + + L+ A H+ K LLENGA+ N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 129 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 188
G TPL A G V L+ +G K ++ + +H A + +LL N+ N
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQNDPN 198
Query: 189 IDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLL 247
D TPL++A Y+ ++ + LL GASV+ Q TPLH A+R+ NV ++ LL
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 248 TDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREGPP 285
D GA ++ + + L AA V +LL G P
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 94.4 bits (233), Expect = 1e-19
Identities = 79/250 (31%), Positives = 121/250 (48%), Gaps = 10/250 (4%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA L + L+ +G +VN N ++ LH A G+V + LL+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 185
T TPL A +G +LL+ GA Q + + SPIH A + H +C+ +LL
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 186 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+ ID TPL+VA C + RV K LL+ GA + + L+ TPLH A ++++V
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRV--AKVLLDKGAK-PNSRALNGFTPLHIACKKNHV 384
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAA--PKSSVEQALLLREGPPALSQLCRLCVRKCL 299
V+ LL GA++ G + L +A+ + + LL R P +S +
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Query: 300 GRACHQAIHK 309
RA H + K
Sbjct: 445 ARAGHTEVAK 454
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/223 (30%), Positives = 107/223 (47%), Gaps = 4/223 (1%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A + + ++ L+ G +++ VT + ++ LH A GH+ K LL+ GA N
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 185
V TPL A +G LL+ AK + +P+H A + GH +++LL N
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS-VDHGQWLDTPLHAAARQSNVEVI 244
N N + TPL++A V+ V LLE AS + TPLH AA+ V V
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE--QALLLREGPP 285
LL + A+ G + L +A ++++ + LL R G P
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 2/204 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A L +K L+ +G + + N + LH A V A++LL+ G N
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
+V G TPL A G A V +LL A L +P+H + GH ++L+ +
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
V +D TPL+VA Y + VK LL+ A V+ L +PLH AA+Q + +++
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 245 HLLTDYGANLKRRNAQGKSALDLA 268
LL GA+ ++ G + L +A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774
Score = 82.8 bits (203), Expect = 4e-16
Identities = 61/220 (27%), Positives = 100/220 (45%), Gaps = 3/220 (1%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA G++ + L+ + + N N ++ LH A ++ K LL G +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-VHLASPIHEAVKRGHRECMEILLAN 185
+G TPL A LL++G A E V +P+H A + GH E + +LL+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
N + TPL++ V L++ G VD + TPLH A+ N++++
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 283
L + A++ + G S L AA + + LLL+ G
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Score = 75.1 bits (183), Expect = 8e-14
Identities = 78/283 (27%), Positives = 113/283 (39%), Gaps = 67/283 (23%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVT----------------------IN------- 97
+PL+ AA + L +K L+ G N N+ T IN
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 98 RVSSLHEACLGGHVACAKALLEN---------------------------------GAHV 124
R+ +LH A A LL+N GA V
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILL 183
N +G TPL A G+ V +LL+ GA+ + + +P+H A + GH EILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 184 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+ I + +P+++A +DCV+ LL+ A +D LD TPLH AA +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHH 351
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 283
V +L D GA R G + L +A K+ V LLL+ G
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Score = 72.8 bits (177), Expect = 4e-13
Identities = 52/165 (31%), Positives = 84/165 (50%), Gaps = 4/165 (2%)
Query: 42 KGNRKEAARIAEEIYGGISDCWADR--SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRV 99
K N+ E AR + YGG ++ + + +PLH AA +G + L+++ N NL + +
Sbjct: 611 KQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 100 SSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL 159
+ LH GHV A L+++G V+ T G TPL A G+ V LL+ A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 160 EVHLA-SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVA 203
+ L SP+H+A ++GH + + +LL N + + TPL +A
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 63.2 bits (152), Expect = 3e-10
Identities = 57/210 (27%), Positives = 84/210 (40%), Gaps = 4/210 (1%)
Query: 72 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 131
AA G L + GV++N N ++ LH A GHV LL + T G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 132 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 190
T L A +G V L+ +GA + +P++ A + H E ++ LL N N +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 191 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDY 250
TPL VA + V L+ G G+ LH AAR + +L
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 251 GANLKRRNAQGKSALDLAAPKSSVEQALLL 280
N + G + L +AA ++ A LL
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 225
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A +G + LI GV V+ T + LH A G++ K LL++ A VN
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEIL 182
T G +PL A G V +LL+ GA ++ +P+ A + G+ ++L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 35.4 bits (80), Expect = 0.069
Identities = 19/54 (35%), Positives = 31/54 (57%)
Query: 229 DTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 282
+T LH AA EV+ L +YGAN+ ++ +G + L +AA ++ +E L E
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 99.0 bits (245), Expect = 5e-21
Identities = 73/232 (31%), Positives = 114/232 (49%), Gaps = 15/232 (6%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 128
LH A+ G+ +K L+ +G N+N + N + L+ A H+ K LLENGA+ + T
Sbjct: 80 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 139
Query: 129 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 188
G TPL A G V +LLE K ++ + +H A ++ + +LL N+ N
Sbjct: 140 EDGFTPLAVALQQGHNQAVAILLENDTKGKVRL---PALHIAARKDDTKSAALLLQNDHN 196
Query: 189 IDHEVPQL--------GTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQS 239
D + + TPL++A Y V+ LL GA+VD + TPLH A+++
Sbjct: 197 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 256
Query: 240 NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA--LLLREGPPALSQ 289
N ++ LL D G + + G + L AA +S +Q LLL G P L++
Sbjct: 257 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAA-RSGHDQVVELLLERGAPLLAR 307
Score = 97.8 bits (242), Expect = 1e-20
Identities = 71/224 (31%), Positives = 111/224 (49%), Gaps = 2/224 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
SPLH AA + +K L+ V+ VT++ +++LH A GH K LL+ A+ N
Sbjct: 313 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 372
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
++G TPL AC + +L+++GA Q +PIH A GH + +LL N
Sbjct: 373 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 432
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVEVI 244
+ D + T L++A +V+ V+ LL GA VD + TPLH A+R E++
Sbjct: 433 GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIV 492
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALS 288
LL + A+ G + L ++A + V+ A +L E A S
Sbjct: 493 QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
Score = 92.8 bits (229), Expect = 4e-19
Identities = 71/219 (32%), Positives = 110/219 (50%), Gaps = 8/219 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA G + L+ +G V+ N ++ LH A G+ K LL+ G ++
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 185
T G TPL A SG V +LLE GA + SP+H A + H EC++ LL +
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333
Query: 186 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+D T L+VA C + RV K LL+ A+ + + L+ TPLH A +++ +
Sbjct: 334 KAPVDDVTLDYLTALHVAAHCGHYRV--TKLLLDKRAN-PNARALNGFTPLHIACKKNRI 390
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
+V+ LL YGA+++ G + + +AA + LLL
Sbjct: 391 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429
Score = 90.9 bits (224), Expect = 1e-18
Identities = 64/218 (29%), Positives = 103/218 (47%), Gaps = 2/218 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A + R+ ++ L+ G ++ +T + ++ +H A GH+ LL+NGA +
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
+ G T L A +G V LL GA +P+H A + G E +++LL +
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
+ D TPL+++ +VD LLE GA+ TPLH AA+ +++V
Sbjct: 499 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 558
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 282
LL A G + L +AA + + ALLL E
Sbjct: 559 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 596
Score = 89.0 bits (219), Expect = 5e-18
Identities = 67/215 (31%), Positives = 99/215 (46%), Gaps = 4/215 (1%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 128
LH AA G++ ++ L+ G V+ + LH A G + LL++ AH + T
Sbjct: 447 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 506
Query: 129 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNV 187
+G TPL + G +VLLE GA L +P+H A K G + ++LL
Sbjct: 507 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 566
Query: 188 NIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNVEVIH 245
D TPL+VA Y LLE GAS H + TPLH AA+++ +++
Sbjct: 567 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS-PHATAKNGYTPLHIAAKKNQMQIAS 625
Query: 246 LLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
L +YGA QG + L LA+ + + LL
Sbjct: 626 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Score = 87.4 bits (215), Expect = 2e-17
Identities = 74/259 (28%), Positives = 109/259 (42%), Gaps = 18/259 (6%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA L+ +G + + N + LH A + A LL GA N
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
VT G TPL A G V +LL+ GA + + +H A + +IL +
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 696
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD----HGQWLDTPLHAAARQSNV 241
+ D TPL VAC Y V V LL+ GA+V+ +G TPLH AA+Q +
Sbjct: 697 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY---TPLHQAAQQGHT 753
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGR 301
+I++L +GA A G +AL +A + L+ ++ K
Sbjct: 754 HIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEK---- 809
Query: 302 ACHQAIHKLHLPEPLERFL 320
HKL++PE + L
Sbjct: 810 ------HKLNVPETMTEVL 822
Score = 79.0 bits (193), Expect = 5e-15
Identities = 62/218 (28%), Positives = 103/218 (47%), Gaps = 2/218 (0%)
Query: 65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 124
+++PLH A+ G+ ++ L+ + + T N + LH + G V A LLE GA
Sbjct: 476 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 535
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILL 183
+ T G TPL A GS +LL+ A A + +P+H A +++ +LL
Sbjct: 536 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 595
Query: 184 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVE 242
+ TPL++A ++ LL GA + + TPLH A+++ + +
Sbjct: 596 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 655
Query: 243 VIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
++ LL D GAN+ G ++L LAA + V A +L
Sbjct: 656 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 693
Score = 70.9 bits (172), Expect = 1e-12
Identities = 64/218 (29%), Positives = 98/218 (44%), Gaps = 12/218 (5%)
Query: 72 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 131
AA G L + + G+++N N +++LH A GHV + LL G+ V+ T G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 132 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 190
T L A +G A V VL++ GA + +P++ A + H + ++ LL N N
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136
Query: 191 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLL--T 248
TPL VA V LLE + G+ LH AAR+ + + LL
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAILLE---NDTKGKVRLPALHIAARKDDTKSAALLLQN 193
Query: 249 DYGANLK------RRNAQGKSALDLAAPKSSVEQALLL 280
D+ A+++ R G + L +AA +V A LL
Sbjct: 194 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 231
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 99.0 bits (245), Expect = 5e-21
Identities = 73/232 (31%), Positives = 114/232 (49%), Gaps = 15/232 (6%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 128
LH A+ G+ +K L+ +G N+N + N + L+ A H+ K LLENGA+ + T
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 160
Query: 129 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 188
G TPL A G V +LLE K ++ + +H A ++ + +LL N+ N
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLENDTKGKVRL---PALHIAARKDDTKSAALLLQNDHN 217
Query: 189 IDHEVPQL--------GTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQS 239
D + + TPL++A Y V+ LL GA+VD + TPLH A+++
Sbjct: 218 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 277
Query: 240 NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA--LLLREGPPALSQ 289
N ++ LL D G + + G + L AA +S +Q LLL G P L++
Sbjct: 278 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAA-RSGHDQVVELLLERGAPLLAR 328
Score = 97.8 bits (242), Expect = 1e-20
Identities = 71/224 (31%), Positives = 111/224 (49%), Gaps = 2/224 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
SPLH AA + +K L+ V+ VT++ +++LH A GH K LL+ A+ N
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
++G TPL AC + +L+++GA Q +PIH A GH + +LL N
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 453
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVEVI 244
+ D + T L++A +V+ V+ LL GA VD + TPLH A+R E++
Sbjct: 454 GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIV 513
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALS 288
LL + A+ G + L ++A + V+ A +L E A S
Sbjct: 514 QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Score = 92.8 bits (229), Expect = 4e-19
Identities = 71/219 (32%), Positives = 110/219 (50%), Gaps = 8/219 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA G + L+ +G V+ N ++ LH A G+ K LL+ G ++
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 185
T G TPL A SG V +LLE GA + SP+H A + H EC++ LL +
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 186 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+D T L+VA C + RV K LL+ A+ + + L+ TPLH A +++ +
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRV--TKLLLDKRAN-PNARALNGFTPLHIACKKNRI 411
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
+V+ LL YGA+++ G + + +AA + LLL
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Score = 90.9 bits (224), Expect = 1e-18
Identities = 64/218 (29%), Positives = 103/218 (47%), Gaps = 2/218 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A + R+ ++ L+ G ++ +T + ++ +H A GH+ LL+NGA +
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
+ G T L A +G V LL GA +P+H A + G E +++LL +
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
+ D TPL+++ +VD LLE GA+ TPLH AA+ +++V
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 282
LL A G + L +AA + + ALLL E
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
Score = 89.0 bits (219), Expect = 5e-18
Identities = 67/215 (31%), Positives = 99/215 (46%), Gaps = 4/215 (1%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 128
LH AA G++ ++ L+ G V+ + LH A G + LL++ AH + T
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 129 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNV 187
+G TPL + G +VLLE GA L +P+H A K G + ++LL
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 188 NIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNVEVIH 245
D TPL+VA Y LLE GAS H + TPLH AA+++ +++
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS-PHATAKNGYTPLHIAAKKNQMQIAS 646
Query: 246 LLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
L +YGA QG + L LA+ + + LL
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 87.4 bits (215), Expect = 2e-17
Identities = 74/259 (28%), Positives = 109/259 (42%), Gaps = 18/259 (6%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA L+ +G + + N + LH A + A LL GA N
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
VT G TPL A G V +LL+ GA + + +H A + +IL +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD----HGQWLDTPLHAAARQSNV 241
+ D TPL VAC Y V V LL+ GA+V+ +G TPLH AA+Q +
Sbjct: 718 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY---TPLHQAAQQGHT 774
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGR 301
+I++L +GA A G +AL +A + L+ ++ K
Sbjct: 775 HIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEK---- 830
Query: 302 ACHQAIHKLHLPEPLERFL 320
HKL++PE + L
Sbjct: 831 ------HKLNVPETMTEVL 843
Score = 79.0 bits (193), Expect = 5e-15
Identities = 62/218 (28%), Positives = 103/218 (47%), Gaps = 2/218 (0%)
Query: 65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 124
+++PLH A+ G+ ++ L+ + + T N + LH + G V A LLE GA
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILL 183
+ T G TPL A GS +LL+ A A + +P+H A +++ +LL
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Query: 184 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVE 242
+ TPL++A ++ LL GA + + TPLH A+++ + +
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 243 VIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
++ LL D GAN+ G ++L LAA + V A +L
Sbjct: 677 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 70.9 bits (172), Expect = 1e-12
Identities = 64/218 (29%), Positives = 98/218 (44%), Gaps = 12/218 (5%)
Query: 72 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 131
AA G L + + G+++N N +++LH A GHV + LL G+ V+ T G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 132 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 190
T L A +G A V VL++ GA + +P++ A + H + ++ LL N N
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 191 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLL--T 248
TPL VA V LLE + G+ LH AAR+ + + LL
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLE---NDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 249 DYGANLK------RRNAQGKSALDLAAPKSSVEQALLL 280
D+ A+++ R G + L +AA +V A LL
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 252
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 99.0 bits (245), Expect = 5e-21
Identities = 73/232 (31%), Positives = 114/232 (49%), Gaps = 15/232 (6%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 128
LH A+ G+ +K L+ +G N+N + N + L+ A H+ K LLENGA+ + T
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 160
Query: 129 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 188
G TPL A G V +LLE K ++ + +H A ++ + +LL N+ N
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLENDTKGKVRL---PALHIAARKDDTKSAALLLQNDHN 217
Query: 189 IDHEVPQL--------GTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQS 239
D + + TPL++A Y V+ LL GA+VD + TPLH A+++
Sbjct: 218 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 277
Query: 240 NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA--LLLREGPPALSQ 289
N ++ LL D G + + G + L AA +S +Q LLL G P L++
Sbjct: 278 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAA-RSGHDQVVELLLERGAPLLAR 328
Score = 97.8 bits (242), Expect = 1e-20
Identities = 71/224 (31%), Positives = 111/224 (49%), Gaps = 2/224 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
SPLH AA + +K L+ V+ VT++ +++LH A GH K LL+ A+ N
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
++G TPL AC + +L+++GA Q +PIH A GH + +LL N
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 453
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVEVI 244
+ D + T L++A +V+ V+ LL GA VD + TPLH A+R E++
Sbjct: 454 GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIV 513
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALS 288
LL + A+ G + L ++A + V+ A +L E A S
Sbjct: 514 QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Score = 92.8 bits (229), Expect = 4e-19
Identities = 71/219 (32%), Positives = 110/219 (50%), Gaps = 8/219 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA G + L+ +G V+ N ++ LH A G+ K LL+ G ++
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 185
T G TPL A SG V +LLE GA + SP+H A + H EC++ LL +
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 186 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+D T L+VA C + RV K LL+ A+ + + L+ TPLH A +++ +
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRV--TKLLLDKRAN-PNARALNGFTPLHIACKKNRI 411
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
+V+ LL YGA+++ G + + +AA + LLL
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Score = 90.9 bits (224), Expect = 1e-18
Identities = 64/218 (29%), Positives = 103/218 (47%), Gaps = 2/218 (0%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A + R+ ++ L+ G ++ +T + ++ +H A GH+ LL+NGA +
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
+ G T L A +G V LL GA +P+H A + G E +++LL +
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
+ D TPL+++ +VD LLE GA+ TPLH AA+ +++V
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 282
LL A G + L +AA + + ALLL E
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
Score = 89.0 bits (219), Expect = 5e-18
Identities = 67/215 (31%), Positives = 99/215 (46%), Gaps = 4/215 (1%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 128
LH AA G++ ++ L+ G V+ + LH A G + LL++ AH + T
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 129 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNV 187
+G TPL + G +VLLE GA L +P+H A K G + ++LL
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 188 NIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNVEVIH 245
D TPL+VA Y LLE GAS H + TPLH AA+++ +++
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS-PHATAKNGYTPLHIAAKKNQMQIAS 646
Query: 246 LLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
L +YGA QG + L LA+ + + LL
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 87.4 bits (215), Expect = 2e-17
Identities = 74/259 (28%), Positives = 109/259 (42%), Gaps = 18/259 (6%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA L+ +G + + N + LH A + A LL GA N
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
VT G TPL A G V +LL+ GA + + +H A + +IL +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD----HGQWLDTPLHAAARQSNV 241
+ D TPL VAC Y V V LL+ GA+V+ +G TPLH AA+Q +
Sbjct: 718 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY---TPLHQAAQQGHT 774
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGR 301
+I++L +GA A G +AL +A + L+ ++ K
Sbjct: 775 HIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEK---- 830
Query: 302 ACHQAIHKLHLPEPLERFL 320
HKL++PE + L
Sbjct: 831 ------HKLNVPETMTEVL 843
Score = 79.0 bits (193), Expect = 5e-15
Identities = 62/218 (28%), Positives = 103/218 (47%), Gaps = 2/218 (0%)
Query: 65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 124
+++PLH A+ G+ ++ L+ + + T N + LH + G V A LLE GA
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILL 183
+ T G TPL A GS +LL+ A A + +P+H A +++ +LL
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Query: 184 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVE 242
+ TPL++A ++ LL GA + + TPLH A+++ + +
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 243 VIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
++ LL D GAN+ G ++L LAA + V A +L
Sbjct: 677 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 70.9 bits (172), Expect = 1e-12
Identities = 64/218 (29%), Positives = 98/218 (44%), Gaps = 12/218 (5%)
Query: 72 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 131
AA G L + + G+++N N +++LH A GHV + LL G+ V+ T G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 132 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 190
T L A +G A V VL++ GA + +P++ A + H + ++ LL N N
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 191 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLL--T 248
TPL VA V LLE + G+ LH AAR+ + + LL
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLE---NDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 249 DYGANLK------RRNAQGKSALDLAAPKSSVEQALLL 280
D+ A+++ R G + L +AA +V A LL
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 252
>gi|94721248 ankyrin repeat and SOCS box-containing protein 1 [Homo
sapiens]
Length = 335
Score = 98.6 bits (244), Expect = 7e-21
Identities = 76/277 (27%), Positives = 122/277 (44%), Gaps = 33/277 (11%)
Query: 63 WADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGA 122
W +PL AA G + LI +G V+LV + ++L+ A + GH+ + LLE GA
Sbjct: 76 WLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGA 135
Query: 123 HVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEIL 182
NG H +TP+++A G A + L+ +GA + HL + R R ++
Sbjct: 136 DPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQ---PRFSRRLTSLV 192
Query: 183 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD---------HGQWLDTP-- 231
+ PLY++ Y + C + LL GA+ D G + +P
Sbjct: 193 VC--------------PLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGC 238
Query: 232 -LHAAARQS-NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREG---PPA 286
+ A R + LL ++GANL + K E + +E P
Sbjct: 239 VMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGRRKVDPEALQVFKEARSVPRT 298
Query: 287 LSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 323
L LCR+ VR+ LG+ I L LP+P+++FLL++
Sbjct: 299 LLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 98.2 bits (243), Expect = 9e-21
Identities = 77/243 (31%), Positives = 119/243 (48%), Gaps = 6/243 (2%)
Query: 47 EAARIAEEIYGGISD--CWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
E A++ ++ + D D +PL AA G + +K L+A +VN + ++L
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340
Query: 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA--KAQLEVH 162
AC GG+V K LLE+GA + +G TPL A +G +LLE GA
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400
Query: 163 LASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV 222
S + A +GH E + LL + +H+ ++ T L AC V+ + LL+ GA V
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 460
Query: 223 D-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ-ALLL 280
+ ++PL AA +VE+ LL + GA+L+ N +G + L AA + E ALLL
Sbjct: 461 NMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520
Query: 281 REG 283
+G
Sbjct: 521 GQG 523
Score = 94.0 bits (232), Expect = 2e-19
Identities = 76/243 (31%), Positives = 121/243 (49%), Gaps = 9/243 (3%)
Query: 47 EAARIAEEIYGGISDCWAD--RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
E AR+ E GI+ + S L A +G L ++ L+ G + T ++L E
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA 164
AC+ GHV A+ LL++GA VN +PL A C G +L+E GA + EV+
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLE-EVNDE 499
Query: 165 --SPIHEAVKRGHRECMEILLANNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGAS 221
+P+ EA + GH E + +LL NI+ + + T L +AC ++ L++ GA
Sbjct: 500 GYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD 559
Query: 222 VDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLL 280
++ G TPL AA++ ++E++ L GAN+ A G +AL A + A +LL
Sbjct: 560 IELG--CSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL 617
Query: 281 REG 283
+ G
Sbjct: 618 QAG 620
Score = 86.7 bits (213), Expect = 3e-17
Identities = 64/195 (32%), Positives = 90/195 (46%), Gaps = 4/195 (2%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
SPL AA G + LI +G ++ V + L EA GH LL GA++N
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 127 VTVH-GATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN 185
T T L ACC G + L++ G A +E+ ++P+ EA + GH E ++ LLA
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAG--ADIELGCSTPLMEAAQEGHLELVKYLLAA 586
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVI 244
N+ T L AC D LL+ GA ++H + TPL AAR +V +
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTV 646
Query: 245 HLLTDYGANLKRRNA 259
L GAN+ R A
Sbjct: 647 QFLISKGANVNRTTA 661
Score = 84.7 bits (208), Expect = 1e-16
Identities = 84/266 (31%), Positives = 113/266 (42%), Gaps = 41/266 (15%)
Query: 64 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACL---------------- 107
+D L EA ++G + A++ L+ +G +VN T S L AC
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 292
Query: 108 ------------------GGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNV 149
GGHV K LL + A VN + G T L AC G V V
Sbjct: 293 VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352
Query: 150 LLEFGAKAQLEVHLA---SPIHEAVKRGHRECMEILLANNVNID-HEVPQLGTPLYVACT 205
LLE G A +E H +P+ EA GH E +LL N I+ H + L +AC
Sbjct: 353 LLESG--ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACY 410
Query: 206 YQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSA 264
++ V+ LLE GA +H + T L A +VEV LL D GA + +S
Sbjct: 411 KGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 470
Query: 265 LDLAAPKSSVEQALLLREGPPALSQL 290
L LAA VE A LL E +L ++
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEV 496
Score = 84.7 bits (208), Expect = 1e-16
Identities = 68/221 (30%), Positives = 107/221 (48%), Gaps = 7/221 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PL A + GR ++ L+A+G N ++ + L A GG+V K LL GA +N
Sbjct: 1152 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 1211
Query: 127 VTVH--GATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHEAVKRGHRECMEIL 182
T G +PL A +G A V +LL+ G+ AQ+E + + + A +G E + +L
Sbjct: 1212 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1271
Query: 183 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH---GQWLDTPLHAAARQS 239
L N++H TPL A + + + LL+ GA V+ DT L AA +
Sbjct: 1272 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1331
Query: 240 NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
+ + LL GA++ RN +G + L LAA ++ LL
Sbjct: 1332 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372
Score = 80.9 bits (198), Expect = 1e-15
Identities = 63/190 (33%), Positives = 92/190 (48%), Gaps = 6/190 (3%)
Query: 97 NRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA- 155
N ++L AC GGH + LLE GA + G TPL A +G V +LL+ GA
Sbjct: 1082 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 1141
Query: 156 -KAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKK 214
+AQ E +P+ A G +E +E+LLA N +H TPL +A + V+ +K
Sbjct: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1201
Query: 215 LLELGASVDH--GQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRR-NAQGKSALDLAAP 270
LL GA ++ G L +PL AA + + LL D G+++ + +AL LA
Sbjct: 1202 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACF 1261
Query: 271 KSSVEQALLL 280
+ E LL
Sbjct: 1262 QGRTEVVSLL 1271
Score = 79.3 bits (194), Expect = 4e-15
Identities = 61/186 (32%), Positives = 89/186 (47%), Gaps = 5/186 (2%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNL-VTINRVSSLHEACLGGHVACAKALLENGAHVN 125
SPL AA G A+K L+ G ++N + NR ++L AC G LL+ A+V
Sbjct: 1220 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1279
Query: 126 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLAS---PIHEAVKRGHRECMEIL 182
G TPL A G A VLL+ GA +S + A +GH + E+L
Sbjct: 1280 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1339
Query: 183 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNV 241
+ +ID + TPL++A +D V+ L++ GA VD TPL AA R+ +V
Sbjct: 1340 IGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHV 1399
Query: 242 EVIHLL 247
+V+ L
Sbjct: 1400 KVVRYL 1405
Score = 65.1 bits (157), Expect = 8e-11
Identities = 56/184 (30%), Positives = 77/184 (41%), Gaps = 7/184 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PL EAA +G L +K L+A G NV+ T ++L AC GH A LL+ GA +
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV--HLASPIHEAVKRGHRECMEILLA 184
+ G TPL A +G V L+ GA + + + A GH +E+LLA
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 185 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLE-----LGASVDHGQWLDTPLHAAARQS 239
+ + H + T L A V LL+ L A L P H R
Sbjct: 686 HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAP 745
Query: 240 NVEV 243
V V
Sbjct: 746 RVPV 749
Score = 57.4 bits (137), Expect = 2e-08
Identities = 40/115 (34%), Positives = 57/115 (49%), Gaps = 2/115 (1%)
Query: 157 AQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLL 216
AQ E + + + A GH E ++ LL +I+H + TPL +A T V V+ LL
Sbjct: 1077 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 1136
Query: 217 ELGASVD--HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAA 269
+ GA ++ + DTPL A EV+ LL GAN + RN + L LAA
Sbjct: 1137 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 1191
Score = 53.9 bits (128), Expect = 2e-07
Identities = 33/89 (37%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 66 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSS-LHEACLGGHVACAKALLENGAHV 124
R+PL +AA G + ++ LI++G NVN T N + L AC GGH+A + LL +GA
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEF 153
G+T L A G + V LL++
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 33.9 bits (76), Expect = 0.20
Identities = 27/116 (23%), Positives = 53/116 (45%), Gaps = 4/116 (3%)
Query: 72 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 131
AA +G + LI +G ++++ + L A GGH+ + L++ GA V+
Sbjct: 1327 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1386
Query: 132 ATPLFNACCSGSAACVNVLL----EFGAKAQLEVHLASPIHEAVKRGHRECMEILL 183
TPL A G V L+ +F + ++ ++A+ + + + CME ++
Sbjct: 1387 ITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIV 1442
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 98.2 bits (243), Expect = 9e-21
Identities = 77/243 (31%), Positives = 119/243 (48%), Gaps = 6/243 (2%)
Query: 47 EAARIAEEIYGGISD--CWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
E A++ ++ + D D +PL AA G + +K L+A +VN + ++L
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340
Query: 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA--KAQLEVH 162
AC GG+V K LLE+GA + +G TPL A +G +LLE GA
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400
Query: 163 LASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV 222
S + A +GH E + LL + +H+ ++ T L AC V+ + LL+ GA V
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 460
Query: 223 D-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ-ALLL 280
+ ++PL AA +VE+ LL + GA+L+ N +G + L AA + E ALLL
Sbjct: 461 NMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520
Query: 281 REG 283
+G
Sbjct: 521 GQG 523
Score = 94.0 bits (232), Expect = 2e-19
Identities = 76/243 (31%), Positives = 121/243 (49%), Gaps = 9/243 (3%)
Query: 47 EAARIAEEIYGGISDCWAD--RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
E AR+ E GI+ + S L A +G L ++ L+ G + T ++L E
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA 164
AC+ GHV A+ LL++GA VN +PL A C G +L+E GA + EV+
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLE-EVNDE 499
Query: 165 --SPIHEAVKRGHRECMEILLANNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGAS 221
+P+ EA + GH E + +LL NI+ + + T L +AC ++ L++ GA
Sbjct: 500 GYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD 559
Query: 222 VDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLL 280
++ G TPL AA++ ++E++ L GAN+ A G +AL A + A +LL
Sbjct: 560 IELG--CSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL 617
Query: 281 REG 283
+ G
Sbjct: 618 QAG 620
Score = 86.7 bits (213), Expect = 3e-17
Identities = 64/195 (32%), Positives = 90/195 (46%), Gaps = 4/195 (2%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
SPL AA G + LI +G ++ V + L EA GH LL GA++N
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 127 VTVH-GATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN 185
T T L ACC G + L++ G A +E+ ++P+ EA + GH E ++ LLA
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAG--ADIELGCSTPLMEAAQEGHLELVKYLLAA 586
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVI 244
N+ T L AC D LL+ GA ++H + TPL AAR +V +
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTV 646
Query: 245 HLLTDYGANLKRRNA 259
L GAN+ R A
Sbjct: 647 QFLISKGANVNRTTA 661
Score = 84.7 bits (208), Expect = 1e-16
Identities = 84/266 (31%), Positives = 113/266 (42%), Gaps = 41/266 (15%)
Query: 64 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACL---------------- 107
+D L EA ++G + A++ L+ +G +VN T S L AC
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 292
Query: 108 ------------------GGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNV 149
GGHV K LL + A VN + G T L AC G V V
Sbjct: 293 VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352
Query: 150 LLEFGAKAQLEVHLA---SPIHEAVKRGHRECMEILLANNVNID-HEVPQLGTPLYVACT 205
LLE G A +E H +P+ EA GH E +LL N I+ H + L +AC
Sbjct: 353 LLESG--ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACY 410
Query: 206 YQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSA 264
++ V+ LLE GA +H + T L A +VEV LL D GA + +S
Sbjct: 411 KGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 470
Query: 265 LDLAAPKSSVEQALLLREGPPALSQL 290
L LAA VE A LL E +L ++
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEV 496
Score = 84.7 bits (208), Expect = 1e-16
Identities = 68/221 (30%), Positives = 107/221 (48%), Gaps = 7/221 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PL A + GR ++ L+A+G N ++ + L A GG+V K LL GA +N
Sbjct: 901 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 960
Query: 127 VTVH--GATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHEAVKRGHRECMEIL 182
T G +PL A +G A V +LL+ G+ AQ+E + + + A +G E + +L
Sbjct: 961 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1020
Query: 183 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH---GQWLDTPLHAAARQS 239
L N++H TPL A + + + LL+ GA V+ DT L AA +
Sbjct: 1021 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1080
Query: 240 NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
+ + LL GA++ RN +G + L LAA ++ LL
Sbjct: 1081 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
Score = 80.9 bits (198), Expect = 1e-15
Identities = 63/190 (33%), Positives = 92/190 (48%), Gaps = 6/190 (3%)
Query: 97 NRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA- 155
N ++L AC GGH + LLE GA + G TPL A +G V +LL+ GA
Sbjct: 831 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 890
Query: 156 -KAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKK 214
+AQ E +P+ A G +E +E+LLA N +H TPL +A + V+ +K
Sbjct: 891 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 950
Query: 215 LLELGASVDH--GQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRR-NAQGKSALDLAAP 270
LL GA ++ G L +PL AA + + LL D G+++ + +AL LA
Sbjct: 951 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACF 1010
Query: 271 KSSVEQALLL 280
+ E LL
Sbjct: 1011 QGRTEVVSLL 1020
Score = 79.3 bits (194), Expect = 4e-15
Identities = 61/186 (32%), Positives = 89/186 (47%), Gaps = 5/186 (2%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNL-VTINRVSSLHEACLGGHVACAKALLENGAHVN 125
SPL AA G A+K L+ G ++N + NR ++L AC G LL+ A+V
Sbjct: 969 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1028
Query: 126 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLAS---PIHEAVKRGHRECMEIL 182
G TPL A G A VLL+ GA +S + A +GH + E+L
Sbjct: 1029 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1088
Query: 183 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNV 241
+ +ID + TPL++A +D V+ L++ GA VD TPL AA R+ +V
Sbjct: 1089 IGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHV 1148
Query: 242 EVIHLL 247
+V+ L
Sbjct: 1149 KVVRYL 1154
Score = 65.1 bits (157), Expect = 8e-11
Identities = 56/184 (30%), Positives = 77/184 (41%), Gaps = 7/184 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PL EAA +G L +K L+A G NV+ T ++L AC GH A LL+ GA +
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV--HLASPIHEAVKRGHRECMEILLA 184
+ G TPL A +G V L+ GA + + + A GH +E+LLA
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 185 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLE-----LGASVDHGQWLDTPLHAAARQS 239
+ + H + T L A V LL+ L A L P H R
Sbjct: 686 HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAP 745
Query: 240 NVEV 243
V V
Sbjct: 746 RVPV 749
Score = 57.4 bits (137), Expect = 2e-08
Identities = 40/115 (34%), Positives = 57/115 (49%), Gaps = 2/115 (1%)
Query: 157 AQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLL 216
AQ E + + + A GH E ++ LL +I+H + TPL +A T V V+ LL
Sbjct: 826 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885
Query: 217 ELGASVD--HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAA 269
+ GA ++ + DTPL A EV+ LL GAN + RN + L LAA
Sbjct: 886 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 940
Score = 56.6 bits (135), Expect = 3e-08
Identities = 59/251 (23%), Positives = 94/251 (37%), Gaps = 45/251 (17%)
Query: 66 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSS-LHEACLGGHVACAKALLENGAHV 124
R+PL +AA G + ++ LI++G NVN T N + L AC GGH+A + LL +GA
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEF------------------------------- 153
G+T L A G + V LL++
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQ 750
Query: 154 ----------GAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVA 203
K V PI G M +++ PQ TP +
Sbjct: 751 ALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPII 810
Query: 204 CTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKS 263
+ + +++ A + DT L A + E++ L + GA+++ R+ +G +
Sbjct: 811 SPSAMLP-IYPAIDIDAQTESNH--DTALTLACAGGHEELVQTLLERGASIEHRDKKGFT 867
Query: 264 ALDLAAPKSSV 274
L LAA V
Sbjct: 868 PLILAATAGHV 878
Score = 33.9 bits (76), Expect = 0.20
Identities = 27/116 (23%), Positives = 53/116 (45%), Gaps = 4/116 (3%)
Query: 72 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 131
AA +G + LI +G ++++ + L A GGH+ + L++ GA V+
Sbjct: 1076 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135
Query: 132 ATPLFNACCSGSAACVNVLL----EFGAKAQLEVHLASPIHEAVKRGHRECMEILL 183
TPL A G V L+ +F + ++ ++A+ + + + CME ++
Sbjct: 1136 ITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIV 1191
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 96.3 bits (238), Expect = 3e-20
Identities = 71/251 (28%), Positives = 113/251 (45%), Gaps = 35/251 (13%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A + R+ ++ L+ G ++ VT + ++ +H A GHV L+ +GA N
Sbjct: 402 TPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-------QLEVHLAS-------------- 165
V G T L A SG A V L++ GA+ Q +H+++
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521
Query: 166 -------------PIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 212
P+H + + GH + LL + ++ + TPL+VA Y +++
Sbjct: 522 GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVA 581
Query: 213 KKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 271
LL+ AS D G+ TPLH AA N +V LL D GA+ G + L +AA K
Sbjct: 582 NLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKK 641
Query: 272 SSVEQALLLRE 282
+ ++ A L E
Sbjct: 642 NQMDIATTLLE 652
Score = 94.7 bits (234), Expect = 1e-19
Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 35/249 (14%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
SPLH A L ++ L+ V V+ VT + +++LH A GH AK LL+ A+ N
Sbjct: 336 SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNA 395
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAK------------------------AQLEVH 162
++G TPL AC + +LL+ GA +QL H
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 455
Query: 163 LASP----------IHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 212
ASP +H A + G E + L+ + ++ + TPL+++ + D V
Sbjct: 456 GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIV 515
Query: 213 KKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 271
++LL+ GAS + TPLH +AR+ + +V L D+GA+L +G + L +AA
Sbjct: 516 QQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKY 575
Query: 272 SSVEQALLL 280
+E A LL
Sbjct: 576 GKLEVANLL 584
Score = 94.0 bits (232), Expect = 2e-19
Identities = 74/254 (29%), Positives = 114/254 (44%), Gaps = 34/254 (13%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 128
LH A+ +G + + L+ + NV+ T ++LH A L G K L+ NGA+VN +
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 129 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNV 187
+G TPL+ A V LL+ GA L +P+ A+++GH + + +LL N+
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDT 197
Query: 188 -----------------------------NIDHEVPQLGTPLYVACTYQRVDCVKKLLEL 218
N D E TPL++A Y ++ LL
Sbjct: 198 KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257
Query: 219 GASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA 277
A+VD D TPLH A+++ N ++ LL D GA + + G + L A +S EQ
Sbjct: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGA-RSGHEQV 316
Query: 278 --LLLREGPPALSQ 289
+LL P LS+
Sbjct: 317 VEMLLDRAAPILSK 330
Score = 93.6 bits (231), Expect = 2e-19
Identities = 75/277 (27%), Positives = 120/277 (43%), Gaps = 41/277 (14%)
Query: 37 HFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTI 96
H K + K AA + + + + +PLH AA G + L+ + V+
Sbjct: 207 HIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTAR 266
Query: 97 NRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAK 156
N ++ LH A G+ K LL+ GA ++ T G TPL SG V +LL+ A
Sbjct: 267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326
Query: 157 AQLEV-HLASPIHEAVKRGHRECMEILLANNVNID----------HEVPQLG-------- 197
+ + SP+H A + H C+++LL +NV +D H G
Sbjct: 327 ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
Query: 198 ---------------TPLYVACTYQRVDCVKKLLELGASV----DHGQWLDTPLHAAARQ 238
TPL++AC R+ ++ LL+ GAS+ + G TP+H AA
Sbjct: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGL---TPIHVAAFM 443
Query: 239 SNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE 275
+V ++ L +GA+ N +G++AL +AA E
Sbjct: 444 GHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE 480
Score = 84.3 bits (207), Expect = 1e-16
Identities = 63/218 (28%), Positives = 104/218 (47%), Gaps = 2/218 (0%)
Query: 65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 124
D++PLH +A G+ ++ L+ QG + N T + + LH + GH A LL++GA +
Sbjct: 499 DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILL 183
+ T G TPL A G N+LL+ A +P+H A +++ +LL
Sbjct: 559 SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618
Query: 184 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVE 242
+ TPL++A ++D LLE GA + + +H AA++ +V+
Sbjct: 619 DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD 678
Query: 243 VIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
++ LL AN+ N G + L LAA + V A +L
Sbjct: 679 MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
Score = 81.6 bits (200), Expect = 8e-16
Identities = 68/259 (26%), Positives = 108/259 (41%), Gaps = 19/259 (7%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA L+ QG + + N + LH A + A LLE GA N
Sbjct: 600 TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA 659
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 185
VT G + A G V++LL A L +P+H A + E+L+
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ 719
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD----HGQWLDTPLHAAARQSNV 241
++D + TPL+V C Y + V LL+ A V+ +G TPLH AA+Q +
Sbjct: 720 GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGY---TPLHQAAQQGHT 776
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGR 301
+I++L A+ G +AL +A R G ++ ++ + +
Sbjct: 777 HIINVLLQNNASPNELTVNGNTALGIAR-----------RLGYISVVDTLKIVTEETMTT 825
Query: 302 ACHQAIHKLHLPEPLERFL 320
HK+++PE + L
Sbjct: 826 TTVTEKHKMNVPETMNEVL 844
Score = 59.7 bits (143), Expect = 3e-09
Identities = 54/186 (29%), Positives = 83/186 (44%), Gaps = 12/186 (6%)
Query: 100 SSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL 159
+S A GH+ A ++NG +N +G L A G V+ LL+ A
Sbjct: 43 ASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDA 102
Query: 160 EVHLA-SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLEL 218
+ +H A G E +++L+ N N++ + TPLY+A ++ VK LL+
Sbjct: 103 ATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDN 162
Query: 219 GAS----VDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSV 274
GAS + G TPL A +Q + +V+ LL + K R AL +AA K
Sbjct: 163 GASQSLATEDG---FTPLAVALQQGHDQVVSLLLENDTKGKVR----LPALHIAARKDDT 215
Query: 275 EQALLL 280
+ A LL
Sbjct: 216 KAAALL 221
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 96.3 bits (238), Expect = 3e-20
Identities = 75/243 (30%), Positives = 117/243 (48%), Gaps = 6/243 (2%)
Query: 47 EAARIAEEIYGGISDCW--ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
E A++ ++ + D D +PL A++ G L +K L+ +VN + ++L
Sbjct: 252 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 311
Query: 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA--KAQLEVH 162
AC GG V K LL GA++ +G TPL A +G VLL+ GA
Sbjct: 312 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371
Query: 163 LASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV 222
S + A +GH + + LL + +H+ ++ T L AC V+ + LL+ GA V
Sbjct: 372 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 431
Query: 223 D-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ-ALLL 280
+ ++PL AA +VE+ LL + GANL+ N +G + L AA + E ALLL
Sbjct: 432 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491
Query: 281 REG 283
+G
Sbjct: 492 AQG 494
Score = 92.0 bits (227), Expect = 6e-19
Identities = 70/221 (31%), Positives = 112/221 (50%), Gaps = 7/221 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
S L A +G L ++ L+ G + T ++L EAC+ GHV A+ LL++GA VN
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA--SPIHEAVKRGHRECMEILLA 184
+PL A C G +L+E GA + EV+ +P+ EA + GH E + +LLA
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLE-EVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 185 NNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEV 243
NI+ + + T L +AC + L++ GA ++ G TPL A+++ ++E+
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG--CSTPLMEASQEGHLEL 550
Query: 244 IHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREG 283
+ L GAN+ A G +AL A + A +LL+ G
Sbjct: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Score = 81.3 bits (199), Expect = 1e-15
Identities = 62/186 (33%), Positives = 92/186 (49%), Gaps = 4/186 (2%)
Query: 101 SLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE 160
SL EAC G V + LL+ G VN T G + L AC +G VLL A +
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 161 VHLA--SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLEL 218
+ +P+ A G+ + +++LL ++ +++ + T L AC VD VK LL
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Query: 219 GASV-DHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGK-SALDLAAPKSSVEQ 276
GA++ DH + TPL AA +VEV +L D+GA + + + K SAL LA K ++
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
Query: 277 ALLLRE 282
L E
Sbjct: 388 VRFLLE 393
Score = 76.6 bits (187), Expect = 3e-14
Identities = 80/257 (31%), Positives = 106/257 (41%), Gaps = 41/257 (15%)
Query: 65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEAC------------------ 106
D L EA + G + A++ L+ +G +VN T S L AC
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
Query: 107 ----------------LGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVL 150
GG++ K LL + A VN + G T L AC G V VL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 151 LEFGAKAQLEVHLA---SPIHEAVKRGHRECMEILLANNVNID-HEVPQLGTPLYVACTY 206
L G A +E H +P+ EA GH E +LL + I+ H + L +AC
Sbjct: 325 LNEG--ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 207 QRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSAL 265
+D V+ LLE GA +H + T L A +VEV LL D GA + +S L
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442
Query: 266 DLAAPKSSVEQALLLRE 282
LAA VE A LL E
Sbjct: 443 TLAACGGHVELAALLIE 459
Score = 75.1 bits (183), Expect = 8e-14
Identities = 54/167 (32%), Positives = 78/167 (46%), Gaps = 3/167 (1%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
SPL AA G + LI +G N+ V + L EA GH LL GA++N
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 127 VTVHGA-TPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN 185
T T L ACC G + + L++ GA +E+ ++P+ EA + GH E ++ LLA+
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGA--DIELGCSTPLMEASQEGHLELVKYLLAS 557
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPL 232
N+ T L AC D LL+ GA +D + + T L
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTIL 604
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 96.3 bits (238), Expect = 3e-20
Identities = 75/243 (30%), Positives = 117/243 (48%), Gaps = 6/243 (2%)
Query: 47 EAARIAEEIYGGISDCW--ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
E A++ ++ + D D +PL A++ G L +K L+ +VN + ++L
Sbjct: 241 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 300
Query: 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA--KAQLEVH 162
AC GG V K LL GA++ +G TPL A +G VLL+ GA
Sbjct: 301 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 360
Query: 163 LASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV 222
S + A +GH + + LL + +H+ ++ T L AC V+ + LL+ GA V
Sbjct: 361 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 420
Query: 223 D-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ-ALLL 280
+ ++PL AA +VE+ LL + GANL+ N +G + L AA + E ALLL
Sbjct: 421 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 480
Query: 281 REG 283
+G
Sbjct: 481 AQG 483
Score = 92.0 bits (227), Expect = 6e-19
Identities = 70/221 (31%), Positives = 112/221 (50%), Gaps = 7/221 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
S L A +G L ++ L+ G + T ++L EAC+ GHV A+ LL++GA VN
Sbjct: 363 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA--SPIHEAVKRGHRECMEILLA 184
+PL A C G +L+E GA + EV+ +P+ EA + GH E + +LLA
Sbjct: 423 PADSFESPLTLAACGGHVELAALLIERGANLE-EVNDEGYTPLMEAAREGHEEMVALLLA 481
Query: 185 NNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEV 243
NI+ + + T L +AC + L++ GA ++ G TPL A+++ ++E+
Sbjct: 482 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG--CSTPLMEASQEGHLEL 539
Query: 244 IHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREG 283
+ L GAN+ A G +AL A + A +LL+ G
Sbjct: 540 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
Score = 81.3 bits (199), Expect = 1e-15
Identities = 62/186 (33%), Positives = 92/186 (49%), Gaps = 4/186 (2%)
Query: 101 SLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE 160
SL EAC G V + LL+ G VN T G + L AC +G VLL A +
Sbjct: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
Query: 161 VHLA--SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLEL 218
+ +P+ A G+ + +++LL ++ +++ + T L AC VD VK LL
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
Query: 219 GASV-DHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGK-SALDLAAPKSSVEQ 276
GA++ DH + TPL AA +VEV +L D+GA + + + K SAL LA K ++
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
Query: 277 ALLLRE 282
L E
Sbjct: 377 VRFLLE 382
Score = 76.6 bits (187), Expect = 3e-14
Identities = 80/257 (31%), Positives = 106/257 (41%), Gaps = 41/257 (15%)
Query: 65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEAC------------------ 106
D L EA + G + A++ L+ +G +VN T S L AC
Sbjct: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253
Query: 107 ----------------LGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVL 150
GG++ K LL + A VN + G T L AC G V VL
Sbjct: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
Query: 151 LEFGAKAQLEVHLA---SPIHEAVKRGHRECMEILLANNVNID-HEVPQLGTPLYVACTY 206
L G A +E H +P+ EA GH E +LL + I+ H + L +AC
Sbjct: 314 LNEG--ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 371
Query: 207 QRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSAL 265
+D V+ LLE GA +H + T L A +VEV LL D GA + +S L
Sbjct: 372 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 431
Query: 266 DLAAPKSSVEQALLLRE 282
LAA VE A LL E
Sbjct: 432 TLAACGGHVELAALLIE 448
Score = 75.1 bits (183), Expect = 8e-14
Identities = 54/167 (32%), Positives = 78/167 (46%), Gaps = 3/167 (1%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
SPL AA G + LI +G N+ V + L EA GH LL GA++N
Sbjct: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488
Query: 127 VTVHGA-TPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN 185
T T L ACC G + + L++ GA +E+ ++P+ EA + GH E ++ LLA+
Sbjct: 489 QTEETQETALTLACCGGFSEVADFLIKAGA--DIELGCSTPLMEASQEGHLELVKYLLAS 546
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPL 232
N+ T L AC D LL+ GA +D + + T L
Sbjct: 547 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTIL 593
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 96.3 bits (238), Expect = 3e-20
Identities = 75/243 (30%), Positives = 117/243 (48%), Gaps = 6/243 (2%)
Query: 47 EAARIAEEIYGGISDCW--ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
E A++ ++ + D D +PL A++ G L +K L+ +VN + ++L
Sbjct: 252 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 311
Query: 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA--KAQLEVH 162
AC GG V K LL GA++ +G TPL A +G VLL+ GA
Sbjct: 312 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371
Query: 163 LASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV 222
S + A +GH + + LL + +H+ ++ T L AC V+ + LL+ GA V
Sbjct: 372 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 431
Query: 223 D-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ-ALLL 280
+ ++PL AA +VE+ LL + GANL+ N +G + L AA + E ALLL
Sbjct: 432 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491
Query: 281 REG 283
+G
Sbjct: 492 AQG 494
Score = 92.0 bits (227), Expect = 6e-19
Identities = 70/221 (31%), Positives = 112/221 (50%), Gaps = 7/221 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
S L A +G L ++ L+ G + T ++L EAC+ GHV A+ LL++GA VN
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA--SPIHEAVKRGHRECMEILLA 184
+PL A C G +L+E GA + EV+ +P+ EA + GH E + +LLA
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLE-EVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 185 NNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEV 243
NI+ + + T L +AC + L++ GA ++ G TPL A+++ ++E+
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG--CSTPLMEASQEGHLEL 550
Query: 244 IHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREG 283
+ L GAN+ A G +AL A + A +LL+ G
Sbjct: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/195 (32%), Positives = 92/195 (47%), Gaps = 4/195 (2%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
SPL AA G + LI +G N+ V + L EA GH LL GA++N
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 127 VTVH-GATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN 185
T T L ACC G + + L++ G A +E+ ++P+ EA + GH E ++ LLA+
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAG--ADIELGCSTPLMEASQEGHLELVKYLLAS 557
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVI 244
N+ T L AC D LL+ GA ++H + TPL AAR ++ +
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617
Query: 245 HLLTDYGANLKRRNA 259
L GAN+ R A
Sbjct: 618 QFLISKGANVNRATA 632
Score = 81.3 bits (199), Expect = 1e-15
Identities = 62/186 (33%), Positives = 92/186 (49%), Gaps = 4/186 (2%)
Query: 101 SLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE 160
SL EAC G V + LL+ G VN T G + L AC +G VLL A +
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 161 VHLA--SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLEL 218
+ +P+ A G+ + +++LL ++ +++ + T L AC VD VK LL
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Query: 219 GASV-DHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGK-SALDLAAPKSSVEQ 276
GA++ DH + TPL AA +VEV +L D+GA + + + K SAL LA K ++
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
Query: 277 ALLLRE 282
L E
Sbjct: 388 VRFLLE 393
Score = 80.5 bits (197), Expect = 2e-15
Identities = 67/223 (30%), Positives = 107/223 (47%), Gaps = 10/223 (4%)
Query: 57 GGISDCWADRS---PLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVAC 113
GG + ++R+ PL A + GR + L+A+G N ++ + L A GG+V
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
Query: 114 AKALLENGAHVNGVTVH--GATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHE 169
K LL GA +N T G +PL A +G V +LL+ G+ AQ+E + + +
Sbjct: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
Query: 170 AVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH---GQ 226
A +G E + +LL N++H TPL A + + + LL+ GA V+
Sbjct: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
Query: 227 WLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAA 269
DT L AA + + + LL GA++ RN +G + L LA+
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
Score = 76.6 bits (187), Expect = 3e-14
Identities = 80/257 (31%), Positives = 106/257 (41%), Gaps = 41/257 (15%)
Query: 65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEAC------------------ 106
D L EA + G + A++ L+ +G +VN T S L AC
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
Query: 107 ----------------LGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVL 150
GG++ K LL + A VN + G T L AC G V VL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 151 LEFGAKAQLEVHLA---SPIHEAVKRGHRECMEILLANNVNID-HEVPQLGTPLYVACTY 206
L G A +E H +P+ EA GH E +LL + I+ H + L +AC
Sbjct: 325 LNEG--ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 207 QRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSAL 265
+D V+ LLE GA +H + T L A +VEV LL D GA + +S L
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442
Query: 266 DLAAPKSSVEQALLLRE 282
LAA VE A LL E
Sbjct: 443 TLAACGGHVELAALLIE 459
Score = 76.3 bits (186), Expect = 4e-14
Identities = 60/186 (32%), Positives = 89/186 (47%), Gaps = 5/186 (2%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNL-VTINRVSSLHEACLGGHVACAKALLENGAHVN 125
SPL AA G + A+K L+ G ++N + NR ++L AC G LL+ A+V
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVE 1251
Query: 126 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLAS---PIHEAVKRGHRECMEIL 182
G TPL A G A VLL+ GA +S + A +GH + E+L
Sbjct: 1252 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1311
Query: 183 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNV 241
+ +ID + TPL++A D V+ L++ GA VD TPL +A R+ +V
Sbjct: 1312 IHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHV 1371
Query: 242 EVIHLL 247
+V+ L
Sbjct: 1372 KVVQYL 1377
Score = 73.6 bits (179), Expect = 2e-13
Identities = 59/190 (31%), Positives = 89/190 (46%), Gaps = 6/190 (3%)
Query: 97 NRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA- 155
N ++L AC GGH L+ A + G TPL A +G V +LL+ G
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113
Query: 156 -KAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKK 214
+AQ E +P+ A G +E +++LLA N +H TPL +A + V+ +K
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
Query: 215 LLELGASVDH--GQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRR-NAQGKSALDLAAP 270
LL GA ++ G L +PL AA +V + LL D G+++ + +AL LA
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233
Query: 271 KSSVEQALLL 280
+ E LL
Sbjct: 1234 QGRAEVVSLL 1243
Score = 67.4 bits (163), Expect = 2e-11
Identities = 71/262 (27%), Positives = 121/262 (46%), Gaps = 17/262 (6%)
Query: 64 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINR--VSSLHEACLGGHVACAKALLENG 121
+D +PL AA+ G + +K L+ G +N T ++ +S L A + GHV K LL+ G
Sbjct: 1154 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213
Query: 122 AHVNG-VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECM 179
+ +N + + T L AC G A V++LL+ A + +P+ EA G+ E
Sbjct: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273
Query: 180 EILLANNVNIDHE-VPQL-GTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAA 236
+LL +++ VP T L +A + L+ GA +D + +TPL A+
Sbjct: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
Query: 237 RQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREGPPALSQLCRLCV 295
+ +V+ LL GA++ + + + L A K V+ L++E S + C+
Sbjct: 1334 NGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDI--ECM 1391
Query: 296 R-------KCLGRACHQAIHKL 310
R K L + CHQ + +
Sbjct: 1392 RYIATITDKELLKKCHQCVETI 1413
Score = 65.9 bits (159), Expect = 5e-11
Identities = 49/155 (31%), Positives = 70/155 (45%), Gaps = 6/155 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PL EA+ +G L +K L+A G NV+ T ++L AC GH A LL+ GA +
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVK----RGHRECMEIL 182
+ G TPL A +G V L+ GA A+ H V GH +E+L
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRAT--ANNDHTVVSLACAGGHLAVVELL 654
Query: 183 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLE 217
LA+ + H + T L A + V LL+
Sbjct: 655 LAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 54.7 bits (130), Expect = 1e-07
Identities = 33/89 (37%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 66 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE-ACLGGHVACAKALLENGAHV 124
R+PL +AA G L ++ LI++G NVN T N ++ AC GGH+A + LL +GA
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEF 153
G+T L A G V+ LL++
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 33.1 bits (74), Expect = 0.34
Identities = 26/116 (22%), Positives = 53/116 (45%), Gaps = 4/116 (3%)
Query: 72 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 131
AA +G + LI +G ++++ + L A GGH + L++ GA V+
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
Query: 132 ATPLFNACCSGSAACVNVLL----EFGAKAQLEVHLASPIHEAVKRGHRECMEILL 183
TPL +A G V L+ +F + + ++A+ + + + +C+E ++
Sbjct: 1359 ITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIV 1414
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 96.3 bits (238), Expect = 3e-20
Identities = 75/243 (30%), Positives = 117/243 (48%), Gaps = 6/243 (2%)
Query: 47 EAARIAEEIYGGISDCW--ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
E A++ ++ + D D +PL A++ G L +K L+ +VN + ++L
Sbjct: 252 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 311
Query: 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA--KAQLEVH 162
AC GG V K LL GA++ +G TPL A +G VLL+ GA
Sbjct: 312 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371
Query: 163 LASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV 222
S + A +GH + + LL + +H+ ++ T L AC V+ + LL+ GA V
Sbjct: 372 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 431
Query: 223 D-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ-ALLL 280
+ ++PL AA +VE+ LL + GANL+ N +G + L AA + E ALLL
Sbjct: 432 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491
Query: 281 REG 283
+G
Sbjct: 492 AQG 494
Score = 92.0 bits (227), Expect = 6e-19
Identities = 70/221 (31%), Positives = 112/221 (50%), Gaps = 7/221 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
S L A +G L ++ L+ G + T ++L EAC+ GHV A+ LL++GA VN
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA--SPIHEAVKRGHRECMEILLA 184
+PL A C G +L+E GA + EV+ +P+ EA + GH E + +LLA
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLE-EVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 185 NNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEV 243
NI+ + + T L +AC + L++ GA ++ G TPL A+++ ++E+
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG--CSTPLMEASQEGHLEL 550
Query: 244 IHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREG 283
+ L GAN+ A G +AL A + A +LL+ G
Sbjct: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/195 (32%), Positives = 92/195 (47%), Gaps = 4/195 (2%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
SPL AA G + LI +G N+ V + L EA GH LL GA++N
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 127 VTVH-GATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN 185
T T L ACC G + + L++ G A +E+ ++P+ EA + GH E ++ LLA+
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAG--ADIELGCSTPLMEASQEGHLELVKYLLAS 557
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVI 244
N+ T L AC D LL+ GA ++H + TPL AAR ++ +
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617
Query: 245 HLLTDYGANLKRRNA 259
L GAN+ R A
Sbjct: 618 QFLISKGANVNRATA 632
Score = 81.3 bits (199), Expect = 1e-15
Identities = 62/186 (33%), Positives = 92/186 (49%), Gaps = 4/186 (2%)
Query: 101 SLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE 160
SL EAC G V + LL+ G VN T G + L AC +G VLL A +
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 161 VHLA--SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLEL 218
+ +P+ A G+ + +++LL ++ +++ + T L AC VD VK LL
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Query: 219 GASV-DHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGK-SALDLAAPKSSVEQ 276
GA++ DH + TPL AA +VEV +L D+GA + + + K SAL LA K ++
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
Query: 277 ALLLRE 282
L E
Sbjct: 388 VRFLLE 393
Score = 80.5 bits (197), Expect = 2e-15
Identities = 67/223 (30%), Positives = 107/223 (47%), Gaps = 10/223 (4%)
Query: 57 GGISDCWADRS---PLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVAC 113
GG + ++R+ PL A + GR + L+A+G N ++ + L A GG+V
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
Query: 114 AKALLENGAHVNGVTVH--GATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHE 169
K LL GA +N T G +PL A +G V +LL+ G+ AQ+E + + +
Sbjct: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
Query: 170 AVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH---GQ 226
A +G E + +LL N++H TPL A + + + LL+ GA V+
Sbjct: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
Query: 227 WLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAA 269
DT L AA + + + LL GA++ RN +G + L LA+
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
Score = 76.6 bits (187), Expect = 3e-14
Identities = 80/257 (31%), Positives = 106/257 (41%), Gaps = 41/257 (15%)
Query: 65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEAC------------------ 106
D L EA + G + A++ L+ +G +VN T S L AC
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
Query: 107 ----------------LGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVL 150
GG++ K LL + A VN + G T L AC G V VL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 151 LEFGAKAQLEVHLA---SPIHEAVKRGHRECMEILLANNVNID-HEVPQLGTPLYVACTY 206
L G A +E H +P+ EA GH E +LL + I+ H + L +AC
Sbjct: 325 LNEG--ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 207 QRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSAL 265
+D V+ LLE GA +H + T L A +VEV LL D GA + +S L
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442
Query: 266 DLAAPKSSVEQALLLRE 282
LAA VE A LL E
Sbjct: 443 TLAACGGHVELAALLIE 459
Score = 76.3 bits (186), Expect = 4e-14
Identities = 60/186 (32%), Positives = 89/186 (47%), Gaps = 5/186 (2%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNL-VTINRVSSLHEACLGGHVACAKALLENGAHVN 125
SPL AA G + A+K L+ G ++N + NR ++L AC G LL+ A+V
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVE 1251
Query: 126 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLAS---PIHEAVKRGHRECMEIL 182
G TPL A G A VLL+ GA +S + A +GH + E+L
Sbjct: 1252 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1311
Query: 183 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNV 241
+ +ID + TPL++A D V+ L++ GA VD TPL +A R+ +V
Sbjct: 1312 IHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHV 1371
Query: 242 EVIHLL 247
+V+ L
Sbjct: 1372 KVVQYL 1377
Score = 73.6 bits (179), Expect = 2e-13
Identities = 59/190 (31%), Positives = 89/190 (46%), Gaps = 6/190 (3%)
Query: 97 NRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA- 155
N ++L AC GGH L+ A + G TPL A +G V +LL+ G
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113
Query: 156 -KAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKK 214
+AQ E +P+ A G +E +++LLA N +H TPL +A + V+ +K
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
Query: 215 LLELGASVDH--GQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRR-NAQGKSALDLAAP 270
LL GA ++ G L +PL AA +V + LL D G+++ + +AL LA
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233
Query: 271 KSSVEQALLL 280
+ E LL
Sbjct: 1234 QGRAEVVSLL 1243
Score = 67.4 bits (163), Expect = 2e-11
Identities = 71/262 (27%), Positives = 121/262 (46%), Gaps = 17/262 (6%)
Query: 64 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINR--VSSLHEACLGGHVACAKALLENG 121
+D +PL AA+ G + +K L+ G +N T ++ +S L A + GHV K LL+ G
Sbjct: 1154 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213
Query: 122 AHVNG-VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECM 179
+ +N + + T L AC G A V++LL+ A + +P+ EA G+ E
Sbjct: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273
Query: 180 EILLANNVNIDHE-VPQL-GTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAA 236
+LL +++ VP T L +A + L+ GA +D + +TPL A+
Sbjct: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
Query: 237 RQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREGPPALSQLCRLCV 295
+ +V+ LL GA++ + + + L A K V+ L++E S + C+
Sbjct: 1334 NGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDI--ECM 1391
Query: 296 R-------KCLGRACHQAIHKL 310
R K L + CHQ + +
Sbjct: 1392 RYIATITDKELLKKCHQCVETI 1413
Score = 65.9 bits (159), Expect = 5e-11
Identities = 49/155 (31%), Positives = 70/155 (45%), Gaps = 6/155 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PL EA+ +G L +K L+A G NV+ T ++L AC GH A LL+ GA +
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVK----RGHRECMEIL 182
+ G TPL A +G V L+ GA A+ H V GH +E+L
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRAT--ANNDHTVVSLACAGGHLAVVELL 654
Query: 183 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLE 217
LA+ + H + T L A + V LL+
Sbjct: 655 LAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 54.7 bits (130), Expect = 1e-07
Identities = 33/89 (37%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 66 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE-ACLGGHVACAKALLENGAHV 124
R+PL +AA G L ++ LI++G NVN T N ++ AC GGH+A + LL +GA
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEF 153
G+T L A G V+ LL++
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 33.1 bits (74), Expect = 0.34
Identities = 26/116 (22%), Positives = 53/116 (45%), Gaps = 4/116 (3%)
Query: 72 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 131
AA +G + LI +G ++++ + L A GGH + L++ GA V+
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
Query: 132 ATPLFNACCSGSAACVNVLL----EFGAKAQLEVHLASPIHEAVKRGHRECMEILL 183
TPL +A G V L+ +F + + ++A+ + + + +C+E ++
Sbjct: 1359 ITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIV 1414
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 94.7 bits (234), Expect = 1e-19
Identities = 64/208 (30%), Positives = 102/208 (49%), Gaps = 3/208 (1%)
Query: 65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 124
DR +H AA G + +K L++ G V + LH A G ++ K LL+ G +
Sbjct: 173 DRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDM 232
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRE-CMEIL 182
N +G TPL AC +G VN L++ GA Q +P+H A H C+E+L
Sbjct: 233 NEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 292
Query: 183 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNV 241
+ N +++ + TPL++ + R + +++ GA +D + +TPLH AAR +
Sbjct: 293 VGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE 352
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAA 269
+I+ L GA+ +R G L LAA
Sbjct: 353 LLINTLITSGADTAKRGIHGMFPLHLAA 380
Score = 85.1 bits (209), Expect = 8e-17
Identities = 67/216 (31%), Positives = 105/216 (48%), Gaps = 4/216 (1%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A A A++ L+ +VN N + LH A V CA+AL+ ++VN
Sbjct: 76 TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV 135
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGHRECMEILLAN 185
G T L +A SG V +LL GA + IH A GH E +++L+++
Sbjct: 136 SDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVI 244
+ + + TPL+ A + + VK LL+LG ++ + +TPLH A V+
Sbjct: 196 GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVV 255
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
+ L D GA + ++N +G + L AA +S AL L
Sbjct: 256 NELIDCGAIVNQKNEKGFTPLHFAA--ASTHGALCL 289
Score = 81.3 bits (199), Expect = 1e-15
Identities = 73/266 (27%), Positives = 107/266 (40%), Gaps = 45/266 (16%)
Query: 59 ISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTI---NRVSSLHEACLGGHVACAK 115
+ D R+P+H AA G L+ LI N V I N + L + L GH C
Sbjct: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
Query: 116 ALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-------VHLA---- 164
+LL GA+V+ G T L +G CV+ LL+ GAK L +HL+
Sbjct: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
Query: 165 ---------------------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLG 197
+ +H A GH C+E+LL V
Sbjct: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTEGNAF 789
Query: 198 TPLYVACTYQRVDCVKKLLE-LGASVDHGQWLD--TPLHAAARQSNVEVIHLLTDYGANL 254
+PL+ A + L++ LGAS+ + TPLHAAA +VE + LL + A +
Sbjct: 790 SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV 849
Query: 255 KRRNAQGKSALDLAAPKSSVEQALLL 280
++ GK+ L +AA +L
Sbjct: 850 NSVDSTGKTPLMMAAENGQTNTVEML 875
Score = 79.7 bits (195), Expect = 3e-15
Identities = 58/205 (28%), Positives = 92/205 (44%), Gaps = 2/205 (0%)
Query: 66 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 125
R+PLH AA G ++ LI G VN ++ LH A + LL++ A VN
Sbjct: 42 RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN 101
Query: 126 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLA 184
+ TPL A + + C L+ + + + +H A GH E +++LL+
Sbjct: 102 ARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS 161
Query: 185 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVEV 243
NI+ + ++ A ++ VK L+ GA V + TPLHAAA + V
Sbjct: 162 RGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISV 221
Query: 244 IHLLTDYGANLKRRNAQGKSALDLA 268
+ L D G ++ NA G + L +A
Sbjct: 222 VKYLLDLGVDMNEPNAYGNTPLHVA 246
Score = 76.3 bits (186), Expect = 4e-14
Identities = 60/207 (28%), Positives = 97/207 (46%), Gaps = 3/207 (1%)
Query: 66 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 125
++PLH AAA + + L+ NVN+ ++LH A GH K LL GA++N
Sbjct: 108 QTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167
Query: 126 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLA 184
+ A G V +L+ GA+ + + +P+H A G ++ LL
Sbjct: 168 AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLD 227
Query: 185 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLH-AAARQSNVE 242
V+++ TPL+VAC + V +L++ GA V+ + TPLH AAA
Sbjct: 228 LGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL 287
Query: 243 VIHLLTDYGANLKRRNAQGKSALDLAA 269
+ LL GA++ ++ GK+ L + A
Sbjct: 288 CLELLVGNGADVNMKSKDGKTPLHMTA 314
Score = 73.6 bits (179), Expect = 2e-13
Identities = 59/214 (27%), Positives = 94/214 (43%), Gaps = 35/214 (16%)
Query: 60 SDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLE 119
SD A SPLH AA G AL+ L+ +++++ + + L A GHV C L+
Sbjct: 545 SDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLIN 604
Query: 120 NGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECM 179
GA + ++ ++ K +PIH A GH EC+
Sbjct: 605 QGASI------------------------LVKDYILK-------RTPIHAAATNGHSECL 633
Query: 180 EILLAN---NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAA 235
+L+ N +D + TPL ++ DCV LL GA+VD +W T LH
Sbjct: 634 RLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRG 693
Query: 236 ARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAA 269
A + E + L +GA R+++G++ + L+A
Sbjct: 694 AVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSA 727
Score = 72.8 bits (177), Expect = 4e-13
Identities = 60/207 (28%), Positives = 92/207 (44%), Gaps = 3/207 (1%)
Query: 66 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 125
++PLH A GR +T+I G ++ N + LH A GH L+ +GA
Sbjct: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA 366
Query: 126 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLA 184
+HG PL A SG + C LL G + +H A G+ EC+ +LL
Sbjct: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
Query: 185 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV-DHGQWLDTPLH-AAARQSNVE 242
+ + + +PL+ A C+ L+ GASV D + TPLH AA ++ +
Sbjct: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGK 486
Query: 243 VIHLLTDYGANLKRRNAQGKSALDLAA 269
+ L AN R+ QG +A+ +A
Sbjct: 487 CLEYLLRNDANPGIRDKQGYNAVHYSA 513
Score = 72.8 bits (177), Expect = 4e-13
Identities = 74/282 (26%), Positives = 114/282 (40%), Gaps = 51/282 (18%)
Query: 57 GGISDCWADR--SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACA 114
G + DC +PLH AA G L + TLI G + I+ + LH A L G C
Sbjct: 329 GAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC 388
Query: 115 KALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKR 173
+ LL +G ++ G T L A G+ C+N+LL GA + SP+H A
Sbjct: 389 RKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAAN 448
Query: 174 GHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVD-CVKKLLELGA------------ 220
+ +C+ L+ + +++ + TPL+ A T C++ LL A
Sbjct: 449 CNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNA 508
Query: 221 ---SVDHGQWLD-------------------------------TPLHAAARQSNVEVIHL 246
S +G L +PLH AA + + + +
Sbjct: 509 VHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEV 568
Query: 247 LTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREGPPAL 287
L +L RN+ G++ LDLAA K VE +L+ +G L
Sbjct: 569 LVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
Score = 70.5 bits (171), Expect = 2e-12
Identities = 68/251 (27%), Positives = 102/251 (40%), Gaps = 57/251 (22%)
Query: 66 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 125
R+ LH AAA G L L L+ G + N S LH A + C AL+ +GA VN
Sbjct: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
Query: 126 GVTVHGATPLFNACCSGS-AACVNVLLEFGAKAQLE-------VHLA------------- 164
+ G TPL A S + C+ LL A + VH +
Sbjct: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA 525
Query: 165 --------------------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGT 198
SP+H A GH + +E+L+ + +++D T
Sbjct: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRT 585
Query: 199 PLYVACTYQRVDCVKKLLELGASVDHGQWL--DTPLHAAARQSNVEVIHLLTDYGANLKR 256
PL +A V+CV L+ GAS+ ++ TP+HAAA + E + LL
Sbjct: 586 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIG------- 638
Query: 257 RNAQGKSALDL 267
NA+ ++A+D+
Sbjct: 639 -NAEPQNAVDI 648
Score = 59.7 bits (143), Expect = 3e-09
Identities = 64/260 (24%), Positives = 101/260 (38%), Gaps = 46/260 (17%)
Query: 66 RSPLHEAAAQGRLLALKTLI--AQGVNVNLVTINR--VSSLHEACLGGHVACAKALLENG 121
R+P+H +AA G + L L+ A ++ N T + ++LH AC GH C + LLE
Sbjct: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779
Query: 122 AHVNGVTVHGATPLFNACCSGSAACVNVLLE-FGAKA--QLEVHLASPIHEAVKRGHREC 178
+ +PL A + + +L++ GA + +P+H A H EC
Sbjct: 780 VFQK-TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
Query: 179 MEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKL------------------LELGA 220
+++LL++N ++ TPL +A + + V+ L L L
Sbjct: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLAC 898
Query: 221 SVDH--------------------GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQ 260
S H L TPLH AAR V+ L GA++ +
Sbjct: 899 SKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDEN 958
Query: 261 GKSALDLAAPKSSVEQALLL 280
G + AP V L L
Sbjct: 959 GYTPALACAPNKDVADCLAL 978
Score = 31.2 bits (69), Expect = 1.3
Identities = 18/51 (35%), Positives = 27/51 (52%)
Query: 230 TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
TPLHAAA + E+I LL GA + ++++ + L A S E +L
Sbjct: 43 TPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVL 93
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 93.6 bits (231), Expect = 2e-19
Identities = 89/304 (29%), Positives = 121/304 (39%), Gaps = 51/304 (16%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA++G L+ L+ + + R ++LHEAC GH AC LL GA N
Sbjct: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAK--AQLEVHLASPIHEAVKRGHRECMEILLA 184
G PL G+ C +LL FGA+ + E +P+H A + GH E ++LL
Sbjct: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
Query: 185 NNVNIDHEVPQLGTPLYVAC-------------TYQRVDCVKKLLELGASVDHG-QWLDT 230
D + TPL AC T + + LL GA D Q
Sbjct: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
Query: 231 PLHAAARQSNVEVIHLL---------TDYGANLKRRNAQGKSALDLAAPKSSVEQALL-- 279
PLH A R+ + V+ LL DYG + A A LA V +ALL
Sbjct: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
Query: 280 -----------------------LREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPL 316
L P +L L R +R L + QA+ +L LP L
Sbjct: 402 GAVRVWPGALPKKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRL 461
Query: 317 ERFL 320
R+L
Sbjct: 462 LRYL 465
Score = 53.1 bits (126), Expect = 3e-07
Identities = 44/127 (34%), Positives = 57/127 (44%), Gaps = 4/127 (3%)
Query: 160 EVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELG 219
E L +P+H A RGH E + +LL D P T L+ AC CV LL G
Sbjct: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAG 216
Query: 220 ASVD-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLK-RRNAQGKSALDLAAPKSSVEQA 277
A + Q PLH +E LL +GA + R + ++ L +AA VE A
Sbjct: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
Query: 278 -LLLREG 283
LLLR G
Sbjct: 277 DLLLRRG 283
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 91.7 bits (226), Expect = 8e-19
Identities = 71/216 (32%), Positives = 102/216 (47%), Gaps = 6/216 (2%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 128
LH AA G + L + G N N+ + LH A G+ + AKAL E G +VN
Sbjct: 449 LHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN 508
Query: 129 VHGATPLFNACCSGSAACVNVLLEFGA---KAQLEVHLASPIHEAVKRGHRECMEILLAN 185
G TPL A G V L E GA + H+A +H AV+R E ++ LL+
Sbjct: 509 REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIA--LHLAVRRCQMEVIKTLLSQ 566
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVEVI 244
+D++ TPL+VAC + V L E ++D ++ TPLH AA ++V+
Sbjct: 567 GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVV 626
Query: 245 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280
L GA+++ GK+A DLA + A LL
Sbjct: 627 RYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 56.2 bits (134), Expect = 4e-08
Identities = 55/217 (25%), Positives = 93/217 (42%), Gaps = 2/217 (0%)
Query: 68 PLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGV 127
PL AA G + L+ LI +G +++ ++++ A GHV K L EN ++
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVK 441
Query: 128 TVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-VHLASPIHEAVKRGHRECMEILLANN 186
G L A G A +L FG+ ++ +P+H A G+ + L
Sbjct: 442 DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAG 501
Query: 187 VNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIH 245
N++ + + TPL A D V+ L E GA ++ + LH A R+ +EVI
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 561
Query: 246 LLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 282
L G + ++ G + L +A ++ + L E
Sbjct: 562 TLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCE 598
Score = 53.5 bits (127), Expect = 2e-07
Identities = 38/150 (25%), Positives = 70/150 (46%), Gaps = 2/150 (1%)
Query: 124 VNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLAS-PIHEAVKRGHRECMEIL 182
VN HG PL A G+ + +L++ G++ ++ S ++ A + GH + ++ L
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431
Query: 183 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNV 241
N +D + L+VA Y D + L G++ + + +TPLH AA
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYY 491
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPK 271
V L + G N+ +N +G++ L A+ +
Sbjct: 492 SVAKALCEAGCNVNIKNREGETPLLTASAR 521
Score = 40.8 bits (94), Expect = 0.002
Identities = 34/127 (26%), Positives = 56/127 (44%), Gaps = 5/127 (3%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PL A+A+G ++ L G ++N + +LH A + K LL G V+
Sbjct: 513 TPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDY 572
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV---HLASPIHEAVKRGHRECMEILL 183
HG TPL AC G+ V L E A L++ + +P+H A G + + L
Sbjct: 573 QDRHGNTPLHVACKDGNMPIVVALCE--ANCNLDISNKYGRTPLHLAANNGILDVVRYLC 630
Query: 184 ANNVNID 190
+++
Sbjct: 631 LMGASVE 637
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 91.3 bits (225), Expect = 1e-18
Identities = 85/282 (30%), Positives = 111/282 (39%), Gaps = 57/282 (20%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA GR ++ L+ G NV + LH AC GH LL +GA N
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-------VHLASPIHEAVKRG----- 174
TPL A G VLL+ GA+ + + LA P +AV G
Sbjct: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKD 179
Query: 175 ----------HRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS--- 221
+ M +L NVN + TPL++A Y RV V+ LL+ GA
Sbjct: 180 ELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHA 239
Query: 222 ------------------------VDHGQ-------WLDTPLHAAARQSNVEVIHLLTDY 250
V HG W TPLH AA ++ VEV LL Y
Sbjct: 240 KDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSY 299
Query: 251 GANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCR 292
GA+ N KSA+DL AP +++ L +L Q R
Sbjct: 300 GADPTLLNCHNKSAIDL-APTPQLKERLAYEFKGHSLLQAAR 340
Score = 79.7 bits (195), Expect = 3e-15
Identities = 71/281 (25%), Positives = 114/281 (40%), Gaps = 58/281 (20%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA R+ ++ L+ G +V+ + LH AC GH A+ L+++GA VN
Sbjct: 528 TPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV 587
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLA-- 184
+ TPL A G +LL+ GA + + + VK G + ++L
Sbjct: 588 ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDA 647
Query: 185 --------------------NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV-- 222
+NVN + TPL++A Y ++ + LL+ GA V
Sbjct: 648 ALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707
Query: 223 -DHG-------------------------------QWLDTPLHAAARQSNVEVIHLLTDY 250
D G +W TPLH AA++ ++ LL +
Sbjct: 708 QDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAH 767
Query: 251 GANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLC 291
GA+ +N +G++ LDL + + ALL PP+ C
Sbjct: 768 GADPTLKNQEGQTPLDLVS--ADDVSALLTAAMPPSALPSC 806
Score = 76.3 bits (186), Expect = 4e-14
Identities = 55/170 (32%), Positives = 77/170 (45%), Gaps = 10/170 (5%)
Query: 106 CLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLL--EFGAKAQLEVHL 163
C GG ACA A E A LF AC +G V L+ E
Sbjct: 6 CAGGGAACASAAAE-------AVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRK 58
Query: 164 ASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD 223
++P+H A G ++ +E LL N N+ PL+ AC++ + V LL GA +
Sbjct: 59 STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118
Query: 224 -HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKS 272
W TPLH AA + ++V +L +GA RN G++ALDLA P +
Sbjct: 119 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
Score = 70.5 bits (171), Expect = 2e-12
Identities = 71/278 (25%), Positives = 115/278 (41%), Gaps = 41/278 (14%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH A+ + ++ ++ VN + +SLH A GH+ + LL G N
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 127 VTVHGATP-----------LFNACCSGSAACVNVLLEFGAKA------------------ 157
+++ G T L G++ LLE AKA
Sbjct: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLE-AAKAGDVETVKKLCTVQSVNCR 520
Query: 158 QLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLE 217
+E ++P+H A +E LL + ++ + PL+ AC+Y + + L++
Sbjct: 521 DIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVK 580
Query: 218 LGASVDHGQ-WLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ 276
GA V+ W TPLH AA + E+ LL +GA+ ++N G + LDL + Q
Sbjct: 581 HGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQ 640
Query: 277 ALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPE 314
LL G AL + + CL R + KL P+
Sbjct: 641 DLL--RGDAALLDAAK---KGCLAR-----VKKLSSPD 668
Score = 69.7 bits (169), Expect = 3e-12
Identities = 74/263 (28%), Positives = 116/263 (44%), Gaps = 29/263 (11%)
Query: 43 GNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIA-QGVNVNLVTINRVSS 101
GN + E I G S+ ADR L EAA G + +K L Q VN + + +
Sbjct: 473 GNENVQQLLQEGISLGNSE--ADRQLL-EAAKAGDVETVKKLCTVQSVNCRDIEGRQSTP 529
Query: 102 LHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-E 160
LH A V+ + LL++GA V+ G PL NAC G +L++ GA + +
Sbjct: 530 LHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVAD 589
Query: 161 VHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVA----------------- 203
+ +P+HEA +G E ++LL + + + TPL +
Sbjct: 590 LWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAAL 649
Query: 204 CTYQRVDCVKKLLELGASVDHGQWLD------TPLHAAARQSNVEVIHLLTDYGANLKRR 257
+ C+ ++ +L +S D+ D TPLH AA +N+EV L +GA++ +
Sbjct: 650 LDAAKKGCLARVKKL-SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQ 708
Query: 258 NAQGKSALDLAAPKSSVEQALLL 280
+ G L AA V+ A LL
Sbjct: 709 DKGGLIPLHNAASYGHVDVAALL 731
Score = 60.5 bits (145), Expect = 2e-09
Identities = 58/211 (27%), Positives = 90/211 (42%), Gaps = 17/211 (8%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA R+ ++ L+ G +V+ + LH AC GH + L+++GA VN
Sbjct: 213 TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNA 272
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGA-KAQLEVHLASPIHEAVKRGHRECMEILLAN 185
+ + TPL A ++LL +GA L H S I A +E
Sbjct: 273 MDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKE-------- 324
Query: 186 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELG-ASVDHGQWLDTPLHAAARQ---SNV 241
+ +E G L A V +KK L L + H Q +T LH AA
Sbjct: 325 --RLAYEFK--GHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRK 380
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKS 272
++ LL GAN+ + + + L +A+ K+
Sbjct: 381 QICELLLRKGANINEKTKEFLTPLHVASEKA 411
Score = 53.1 bits (126), Expect = 3e-07
Identities = 62/245 (25%), Positives = 105/245 (42%), Gaps = 30/245 (12%)
Query: 65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 124
D PLH A + G + L+ G VN + + + + LHEA V LL GA
Sbjct: 244 DLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADP 303
Query: 125 NGVTVHGATPLFNACCSGSAACV------NVLLEFGAKA---QLEVHLA----------- 164
+ H + + A + + LL+ +A +++ HL+
Sbjct: 304 TLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQT 363
Query: 165 --SPIHEAVKRGH---RECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELG 219
+ +H A + ++ E+LL NI+ + + TPL+VA D V+ +++
Sbjct: 364 HETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHE 423
Query: 220 ASVDHGQWL-DTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQAL 278
A V+ L T LH AA +++ LL YG + + QG +AL + +V+Q
Sbjct: 424 AKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG--NENVQQ-- 479
Query: 279 LLREG 283
LL+EG
Sbjct: 480 LLQEG 484
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 90.5 bits (223), Expect = 2e-18
Identities = 65/212 (30%), Positives = 103/212 (48%), Gaps = 6/212 (2%)
Query: 66 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 125
++PLH AA G + +K L +QG ++ N + LH A G V + LL++GA +
Sbjct: 495 KTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPD 554
Query: 126 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLA 184
+ G PL A G +LL +GA +L H +P+H A +GH E + +L
Sbjct: 555 ALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAE 614
Query: 185 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGA---SVDHGQWLDTPLHAAARQSNV 241
++ N+ TPL++A + V LL+ GA + + W TPLH A ++S
Sbjct: 615 SHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW--TPLHLAVQRSTF 672
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSS 273
+ L ++ AN+ RN G + LAA K +
Sbjct: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGN 704
Score = 81.6 bits (200), Expect = 8e-16
Identities = 72/251 (28%), Positives = 113/251 (45%), Gaps = 8/251 (3%)
Query: 37 HFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTI 96
HF + +G+ ++ + + +PL AA + L+A G + N V
Sbjct: 367 HFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDE 426
Query: 97 NRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAK 156
+ + LH A G A+ LL++GA V+ G TPL A + +L+ A
Sbjct: 427 DGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQAD 486
Query: 157 AQL-EVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKL 215
L E +P+H A GH +++L + +D + L TPL++A +V ++ L
Sbjct: 487 PNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHL 546
Query: 216 LELGASVDHGQWLDT----PLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 271
L+ GA D LD PLH AA + + +L YGA+L+ QG + L LAA K
Sbjct: 547 LKSGAVPDA---LDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
Query: 272 SSVEQALLLRE 282
+E LL E
Sbjct: 604 GHLEIIHLLAE 614
Score = 70.1 bits (170), Expect = 3e-12
Identities = 58/183 (31%), Positives = 88/183 (48%), Gaps = 4/183 (2%)
Query: 68 PLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGV 127
PLH AAA+G+ L K L+ G ++ L T + LH A GH+ L E+ A++ +
Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL 622
Query: 128 TVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGHRECMEILLANN 186
TPL A G A V+ LL+ GA E +P+H AV+R + LL ++
Sbjct: 623 GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHH 682
Query: 187 VNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 244
N+ H ++G TP ++A +K L+E GA +D + TPL A R ++
Sbjct: 683 ANV-HARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIM 741
Query: 245 HLL 247
L
Sbjct: 742 SFL 744
Score = 62.8 bits (151), Expect = 4e-10
Identities = 58/198 (29%), Positives = 89/198 (44%), Gaps = 5/198 (2%)
Query: 97 NRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAK 156
N+V+ LH G V + LL + V+ T G TPL A +LL GA
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 157 A-QLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKL 215
A +++ +P+H A + G +LL + +D + + TPL++A + + L
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
Query: 216 LELGASVD-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSV 274
+ A + H TPLH AA +V ++ LLT GA L + ++ L LA + V
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
Query: 275 EQAL-LLREG--PPALSQ 289
LL+ G P AL Q
Sbjct: 541 RAIQHLLKSGAVPDALDQ 558
>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
isoform 2 [Homo sapiens]
Length = 318
Score = 89.4 bits (220), Expect = 4e-18
Identities = 74/267 (27%), Positives = 130/267 (48%), Gaps = 15/267 (5%)
Query: 69 LHEAAAQGRLLALKTLIAQGVNVNLVT-INRVSSLHEACLGGHVACAKALLENGAH---V 124
LH +AA+G+ ++ + G + + I ++LH A + G A+ +LE+ +
Sbjct: 51 LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
Query: 125 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGHRECMEILL 183
N + G TPL A G + V +LLEF A+ L +P+ A+ R C++ILL
Sbjct: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
Query: 184 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 241
+N NID Q G L A + L+ GA + G+ D TPLH +A + +V
Sbjct: 171 DHNANIDI---QNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
Query: 242 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALL-----LREGPPALSQLCRLCVR 296
+L +YGA+ RN +G++ L ++ S + L + P L LCR+ +R
Sbjct: 228 LCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIR 287
Query: 297 KCLGRACHQAIHKLHLPEPLERFLLYQ 323
+C+G + + +L + + ++ +L ++
Sbjct: 288 QCIGLQNLKLLDELPIAKVMKDYLKHK 314
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 89.0 bits (219), Expect = 5e-18
Identities = 81/258 (31%), Positives = 104/258 (40%), Gaps = 56/258 (21%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
SPLH AA GR ++ L+ G NV+ + LH AC GH LL GA N
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNA 277
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-------VHLASP------------- 166
TPL A G VLL+ GA + + LA P
Sbjct: 278 RDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKD 337
Query: 167 -IHEAVKRGHRE-CMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV-- 222
+ EA + G+ E M +L NVN + TPL++A Y RV V+ LL+ GA V
Sbjct: 338 ELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 397
Query: 223 -------------------------DHGQ-------WLDTPLHAAARQSNVEVIHLLTDY 250
HG W TPLH AA ++ VEV LL +
Sbjct: 398 KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 457
Query: 251 GANLKRRNAQGKSALDLA 268
GA+ N GKSA+D+A
Sbjct: 458 GADPTLVNCHGKSAVDMA 475
Score = 83.2 bits (204), Expect = 3e-16
Identities = 72/281 (25%), Positives = 113/281 (40%), Gaps = 58/281 (20%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA R+ ++ L+ G +V+ + LH AC GH A+ L+ +GA VN
Sbjct: 686 TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV 745
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN- 185
+ TPL A G +LL+ GA + + + VK G + ++L +
Sbjct: 746 ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDA 805
Query: 186 ---------------------NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV-- 222
N+N + TPL++A Y ++ + LLE GA V
Sbjct: 806 ALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNA 865
Query: 223 -DHG-------------------------------QWLDTPLHAAARQSNVEVIHLLTDY 250
D G +W TPLH AA++ ++ LL +
Sbjct: 866 QDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAH 925
Query: 251 GANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLC 291
GA+ +N +G++ LDLA +ALL+ PP C
Sbjct: 926 GADPTMKNQEGQTPLDLATADDI--RALLIDAMPPEALPTC 964
Score = 75.9 bits (185), Expect = 5e-14
Identities = 74/281 (26%), Positives = 117/281 (41%), Gaps = 47/281 (16%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA + ++ L G +N + ++LH A L GH+ + LL G+ +
Sbjct: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEF--------------GAKA--------------- 157
+++ G F A G+ A +L E +KA
Sbjct: 620 ISLQG----FTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNV 675
Query: 158 ---QLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKK 214
LE ++P+H A +E LL + ++ + PL+ AC+Y + +
Sbjct: 676 NCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAEL 735
Query: 215 LLELGASVDHGQ-WLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSS 273
L+ GASV+ W TPLH AA + E+ LL +GA+ ++N G + LDL +
Sbjct: 736 LVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDT 795
Query: 274 VEQALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPE 314
Q LL G AL + + CL R + KL PE
Sbjct: 796 DIQDLL--RGDAALLDAAK---KGCLAR-----VQKLCTPE 826
Score = 65.5 bits (158), Expect = 6e-11
Identities = 66/241 (27%), Positives = 112/241 (46%), Gaps = 28/241 (11%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA R+ ++ L+ G +V+ + LH AC GH + LL++GA VN
Sbjct: 371 TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 430
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGA---------KAQLEVHLASPIHEAVK---RG 174
+ + TPL A ++LL GA K+ +++ + E + +G
Sbjct: 431 MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKG 490
Query: 175 H------REC----MEILLANNVNIDHEVPQL-GTPLYVACTY---QRVDCVKKLLELGA 220
H RE ++ LA + I+ + PQ T L+ A +R + LL GA
Sbjct: 491 HSLLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 549
Query: 221 SV-DHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALL 279
+V + + TPLH AA +++ +V+ +L +GA + + G++AL AA ++ L
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609
Query: 280 L 280
L
Sbjct: 610 L 610
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 88.2 bits (217), Expect = 9e-18
Identities = 69/229 (30%), Positives = 100/229 (43%), Gaps = 19/229 (8%)
Query: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
+PLH AA++G L+ L+ + + R ++LHEAC GH AC LL GA N
Sbjct: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
Query: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAK--AQLEVHLASPIHEAVKRGHRECMEILLA 184
G PL G+ C +LL FGA+ + E +P+H A + GH E ++LL
Sbjct: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
Query: 185 NNVNIDHEVPQLGTPLYVAC-------------TYQRVDCVKKLLELGASVDHG-QWLDT 230
D + TPL AC T + + LL GA D Q
Sbjct: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
Query: 231 PLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALD--LAAPKSSVEQA 277
PLH A R+ + V+ LL G + + G + L L P +++ Q+
Sbjct: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQS 390
Score = 53.1 bits (126), Expect = 3e-07
Identities = 44/127 (34%), Positives = 57/127 (44%), Gaps = 4/127 (3%)
Query: 160 EVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELG 219
E L +P+H A RGH E + +LL D P T L+ AC CV LL G
Sbjct: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAG 216
Query: 220 ASVD-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLK-RRNAQGKSALDLAAPKSSVEQA 277
A + Q PLH +E LL +GA + R + ++ L +AA VE A
Sbjct: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
Query: 278 -LLLREG 283
LLLR G
Sbjct: 277 DLLLRRG 283
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,218,927
Number of Sequences: 37866
Number of extensions: 523546
Number of successful extensions: 5249
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 309
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 1357
Number of HSP's gapped (non-prelim): 1624
length of query: 323
length of database: 18,247,518
effective HSP length: 102
effective length of query: 221
effective length of database: 14,385,186
effective search space: 3179126106
effective search space used: 3179126106
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.