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Search of human proteins with 17981694
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|17981694 cyclin-dependent kinase inhibitor 2B isoform 1
[Homo sapiens]
(138 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|17981694 cyclin-dependent kinase inhibitor 2B isoform 1 [Homo... 276 3e-75
gi|4502749 cyclin-dependent kinase inhibitor 2A isoform 1 [Homo ... 209 6e-55
gi|17981696 cyclin-dependent kinase inhibitor 2B isoform 2 [Homo... 106 5e-24
gi|4502753 cyclin-dependent kinase inhibitor 2D [Homo sapiens] 103 5e-23
gi|17981702 cyclin-dependent kinase inhibitor 2D [Homo sapiens] 103 5e-23
gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens] 91 2e-19
gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens] 91 2e-19
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 65 1e-11
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 64 3e-11
gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo sapi... 59 1e-09
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 57 4e-09
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 57 4e-09
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 55 1e-08
gi|55770876 notch4 preproprotein [Homo sapiens] 55 2e-08
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 55 2e-08
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 54 4e-08
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 54 4e-08
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 54 4e-08
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 54 5e-08
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 54 5e-08
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 54 5e-08
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 54 5e-08
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 54 5e-08
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 54 5e-08
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 54 5e-08
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 53 9e-08
gi|148833508 notch1 preproprotein [Homo sapiens] 52 2e-07
gi|110431370 espin [Homo sapiens] 52 2e-07
gi|98985804 cyclin-dependent kinase inhibitor 2A isoform 3 [Homo... 51 3e-07
gi|14249672 protein phosphatase 1, regulatory (inhibitor) subuni... 51 3e-07
>gi|17981694 cyclin-dependent kinase inhibitor 2B isoform 1 [Homo
sapiens]
Length = 138
Score = 276 bits (707), Expect = 3e-75
Identities = 138/138 (100%), Positives = 138/138 (100%)
Query: 1 MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSAR 60
MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSAR
Sbjct: 1 MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSAR 60
Query: 61 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA
Sbjct: 61 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
Query: 121 EERGHRDVAGYLRTATGD 138
EERGHRDVAGYLRTATGD
Sbjct: 121 EERGHRDVAGYLRTATGD 138
>gi|4502749 cyclin-dependent kinase inhibitor 2A isoform 1 [Homo
sapiens]
Length = 156
Score = 209 bits (532), Expect = 6e-55
Identities = 110/133 (82%), Positives = 114/133 (85%), Gaps = 4/133 (3%)
Query: 9 PSGGGSDEG----LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAEL 64
P+ G S E LA+AAARG VE+VR LLEAGA PN N +GRR IQVMMMGSARVAEL
Sbjct: 3 PAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAEL 62
Query: 65 LLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERG 124
LLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE G
Sbjct: 63 LLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELG 122
Query: 125 HRDVAGYLRTATG 137
HRDVA YLR A G
Sbjct: 123 HRDVARYLRAAAG 135
>gi|17981696 cyclin-dependent kinase inhibitor 2B isoform 2 [Homo
sapiens]
Length = 78
Score = 106 bits (265), Expect = 5e-24
Identities = 53/53 (100%), Positives = 53/53 (100%)
Query: 1 MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQV 53
MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQV
Sbjct: 1 MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQV 53
>gi|4502753 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
Length = 166
Score = 103 bits (257), Expect = 5e-23
Identities = 60/116 (51%), Positives = 75/116 (64%), Gaps = 2/116 (1%)
Query: 18 LASAAARGLVEKVRQLLEAG-ADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCAD 76
L+ AAARG V++VR+LL P+ +NRFG+ A+QVMM GS +A LL GA PN D
Sbjct: 12 LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQD 71
Query: 77 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
+ T PVHDAAR GFLDTL VL GA ++V D G LP+ LA + GH V +L
Sbjct: 72 TSG-TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
>gi|17981702 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
Length = 166
Score = 103 bits (257), Expect = 5e-23
Identities = 60/116 (51%), Positives = 75/116 (64%), Gaps = 2/116 (1%)
Query: 18 LASAAARGLVEKVRQLLEAG-ADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCAD 76
L+ AAARG V++VR+LL P+ +NRFG+ A+QVMM GS +A LL GA PN D
Sbjct: 12 LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQD 71
Query: 77 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
+ T PVHDAAR GFLDTL VL GA ++V D G LP+ LA + GH V +L
Sbjct: 72 TSG-TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
>gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
Length = 168
Score = 91.3 bits (225), Expect = 2e-19
Identities = 53/115 (46%), Positives = 70/115 (60%), Gaps = 1/115 (0%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADP 77
LASAAARG +E++ LL+ + N N FGR A+QVM +G+ +A LLL GA P+ D
Sbjct: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKD- 67
Query: 78 ATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
T +HDAAR GFLDTL L A +++ D G LP+ LA + GH V +L
Sbjct: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFL 122
>gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
Length = 168
Score = 91.3 bits (225), Expect = 2e-19
Identities = 53/115 (46%), Positives = 70/115 (60%), Gaps = 1/115 (0%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADP 77
LASAAARG +E++ LL+ + N N FGR A+QVM +G+ +A LLL GA P+ D
Sbjct: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKD- 67
Query: 78 ATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
T +HDAAR GFLDTL L A +++ D G LP+ LA + GH V +L
Sbjct: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFL 122
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 65.5 bits (158), Expect = 1e-11
Identities = 43/107 (40%), Positives = 59/107 (55%), Gaps = 2/107 (1%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCAD 76
L +A VE V+QLLE GADP + GR A+ G+ ++ +LLL HGA+PN D
Sbjct: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
Query: 77 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEER 123
T P+H AA + + L R GAR+D D GR P+ LA+ +
Sbjct: 174 GLGNT-PLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 64.3 bits (155), Expect = 3e-11
Identities = 44/122 (36%), Positives = 60/122 (49%), Gaps = 2/122 (1%)
Query: 12 GGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAI-QVMMMGSARVAELLLLHGA 70
G L AAA G + + LL GADP +R GR A+ + G +LL+ GA
Sbjct: 234 GAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGA 293
Query: 71 EPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAG 130
E + D LT P+H A+REG ++ L GA++D + P+ LA ERGH G
Sbjct: 294 EVDARDTLGLT-PLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVG 352
Query: 131 YL 132
L
Sbjct: 353 LL 354
Score = 58.5 bits (140), Expect = 2e-09
Identities = 44/123 (35%), Positives = 61/123 (49%), Gaps = 2/123 (1%)
Query: 11 GGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQV-MMMGSARVAELLLLHG 69
G G D L AAA G +R LL GA + + G A+ + +G ++ E+LL HG
Sbjct: 200 GAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHG 259
Query: 70 AEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVA 129
A+P D + +H AA G L + +L GA +D RD G P+ A GH +VA
Sbjct: 260 ADPGIRDRHGRS-ALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVA 318
Query: 130 GYL 132
G L
Sbjct: 319 GCL 321
Score = 45.1 bits (105), Expect = 2e-05
Identities = 43/137 (31%), Positives = 56/137 (40%), Gaps = 5/137 (3%)
Query: 2 REENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQV-MMMGSAR 60
R E + G G L A RG V QLL GA + GR + + ++ G A
Sbjct: 32 RTEGPSVVQGWGH---LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAP 88
Query: 61 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
+ LLL GA D A T +H+AA G +L + GA R G P+ A
Sbjct: 89 LVRLLLQRGAPVGAVDRAGRT-ALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWA 147
Query: 121 EERGHRDVAGYLRTATG 137
GH +A L A G
Sbjct: 148 AALGHTLLAARLLEAPG 164
>gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo
sapiens]
Length = 588
Score = 58.9 bits (141), Expect = 1e-09
Identities = 42/124 (33%), Positives = 61/124 (49%), Gaps = 6/124 (4%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCAD 76
L A GLVE VR LLE G PN N G + + + GS + L+ H D
Sbjct: 115 LTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS---LD 171
Query: 77 PATLTR--PVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRT 134
+ R +H+AA++G D + +L + G + +RD +G P+ +A E GH DV +L
Sbjct: 172 QPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIH 231
Query: 135 ATGD 138
GD
Sbjct: 232 KGGD 235
Score = 26.6 bits (57), Expect = 7.0
Identities = 17/42 (40%), Positives = 22/42 (52%), Gaps = 2/42 (4%)
Query: 33 LLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNC 74
LL AGADPN ++ + V + + LLL HGA NC
Sbjct: 369 LLAAGADPN-LDPLNCLLVAVRA-NNYEIVRLLLSHGANVNC 408
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 57.4 bits (137), Expect = 4e-09
Identities = 41/116 (35%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARVAELLLLHGAEPNCAD 76
L AA G E V+ LL GA+ N ++ RRAI MG V +LL+ HGAE C D
Sbjct: 144 LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD 203
Query: 77 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
+ T P+H AA G + + L G ++ +A+G P+ +A G V L
Sbjct: 204 KKSYT-PLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNEL 258
Score = 39.3 bits (90), Expect = 0.001
Identities = 37/156 (23%), Positives = 57/156 (36%), Gaps = 36/156 (23%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVA--------------- 62
L +AA+ G++ V+ LL+ G D N N +G + V V
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269
Query: 63 --------------------ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRA 102
ELL+ +GA+ N T P+H A G + ++
Sbjct: 270 EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKT-PLHMTALHGRFSRSQTIIQS 328
Query: 103 GARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD 138
GA +D D G P+ +A GH + L T+ D
Sbjct: 329 GAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
Score = 37.4 bits (85), Expect = 0.004
Identities = 21/51 (41%), Positives = 29/51 (56%)
Query: 75 ADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGH 125
+D P+H AA G L VL ++ LDVR++ GR P+DLA +GH
Sbjct: 545 SDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGH 595
Score = 35.4 bits (80), Expect = 0.015
Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 2/101 (1%)
Query: 12 GGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAI-QVMMMGSARVAELLLLHGA 70
G L + G + V LL GA+ + +++GR A+ + + G + LL HGA
Sbjct: 651 GNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA 710
Query: 71 EPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDA 111
+ D T P+H +A G + L L ++ A +D A
Sbjct: 711 KCLLRDSRGRT-PIHLSAACGHIGVLGALLQSAASMDANPA 750
Score = 34.3 bits (77), Expect = 0.034
Identities = 38/114 (33%), Positives = 50/114 (43%), Gaps = 9/114 (7%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMG-SARVAELLLLHGAEPNCAD 76
L +AAA G +E + LL GAD N ++FGR + + + L+ GA N D
Sbjct: 409 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD 468
Query: 77 PATLTRPVHDAAREGFLDT----LVVLHRAGARLDVRDAWGRLPVDLAEERGHR 126
T P+H AA DT L L R A +RD G V + GHR
Sbjct: 469 ERGCT-PLHYAATS---DTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHR 518
Score = 32.0 bits (71), Expect = 0.17
Identities = 34/117 (29%), Positives = 51/117 (43%), Gaps = 5/117 (4%)
Query: 20 SAAARGLVEKVRQLLEAGADPNGVN-RFGRRAIQVMMM---GSARVAELLLLHGAEPNCA 75
+AA G E +R L+ N V+ + G +M+ G LL GA +
Sbjct: 623 AAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAK 682
Query: 76 DPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
D T +H A G + + L + GA+ +RD+ GR P+ L+ GH V G L
Sbjct: 683 DKWGRTA-LHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738
Score = 29.6 bits (65), Expect = 0.83
Identities = 33/141 (23%), Positives = 57/141 (40%), Gaps = 17/141 (12%)
Query: 11 GGGSDEGLAS---------AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARV 61
G G+D + S A G + + ++++GA + ++ G + + +AR
Sbjct: 294 GNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI----AARY 349
Query: 62 AELLLLHGAEPNCADPATL----TRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV 117
LL++ + AD A P+H AA GF D L +G +D D +GR +
Sbjct: 350 GHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCL 409
Query: 118 DLAEERGHRDVAGYLRTATGD 138
A G+ + L D
Sbjct: 410 HAAAAGGNLECLNLLLNTGAD 430
Score = 26.2 bits (56), Expect = 9.2
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 62 AELLL--LHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDL 119
AE+L+ L + N D T P+H AA ++ L +L A+++ D+ G+ P+ +
Sbjct: 804 AEMLIDTLGASIVNATDSKGRT-PLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMM 862
Query: 120 AEERGHRDVAGYL 132
A E G + L
Sbjct: 863 AAENGQTNTVEML 875
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 57.4 bits (137), Expect = 4e-09
Identities = 41/120 (34%), Positives = 59/120 (49%), Gaps = 2/120 (1%)
Query: 3 EENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARV 61
E+ + G L AA G + V LL+ GA+ + G + G A V
Sbjct: 47 EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEV 106
Query: 62 AELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAE 121
LLL HGA+PN D T P+H+AA +G +D +VL + GA +R+ GR +DLA+
Sbjct: 107 VNLLLRHGADPNARDNWNYT-PLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLAD 165
Score = 51.2 bits (121), Expect = 3e-07
Identities = 37/124 (29%), Positives = 60/124 (48%), Gaps = 11/124 (8%)
Query: 15 DEGLASAAARGLVEKVRQLLEAGADPNGVN---RFGRRAIQVMMMG---SARVAELLLLH 68
D L AA +G + +V++L + P+ VN GR + + + + VAE LL H
Sbjct: 646 DAALLDAAKKGCLARVKKL----SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQH 701
Query: 69 GAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDV 128
GA+ N D L P+H+AA G +D +L + A ++ D W P+ A ++G +
Sbjct: 702 GADVNAQDKGGLI-PLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQL 760
Query: 129 AGYL 132
L
Sbjct: 761 CALL 764
Score = 49.3 bits (116), Expect = 1e-06
Identities = 41/123 (33%), Positives = 59/123 (47%), Gaps = 3/123 (2%)
Query: 12 GGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARVAELLLLHGA 70
G L AA V V LL+ GAD + ++ G + G VAELL+ HGA
Sbjct: 524 GRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGA 583
Query: 71 EPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAG 130
N AD T P+H+AA +G + +L + GA ++ G P+DL ++ G D+
Sbjct: 584 VVNVADLWKFT-PLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKD-GDTDIQD 641
Query: 131 YLR 133
LR
Sbjct: 642 LLR 644
Score = 49.3 bits (116), Expect = 1e-06
Identities = 41/136 (30%), Positives = 61/136 (44%), Gaps = 21/136 (15%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELL-----LLHGAEP 72
L AAA+G E + LL+ GADP NR G + ++ G + +LL LL A+
Sbjct: 596 LHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKK 655
Query: 73 NC-------ADPATL---------TRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP 116
C + P + + P+H AA L+ L + GA ++ +D G +P
Sbjct: 656 GCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIP 715
Query: 117 VDLAEERGHRDVAGYL 132
+ A GH DVA L
Sbjct: 716 LHNAASYGHVDVAALL 731
Score = 43.1 bits (100), Expect = 7e-05
Identities = 42/136 (30%), Positives = 58/136 (42%), Gaps = 20/136 (14%)
Query: 10 SGGGSDEGLASAAARGLVEKVRQLLEA--GADPNGVNRF------------GRRAIQVMM 55
+GGG+ ASAAA + R+L EA D V R GR++ +
Sbjct: 7 AGGGA--ACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHF 64
Query: 56 ---MGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAW 112
G V E LL +GA D L P+H+A G + + +L R GA + RD W
Sbjct: 65 AAGFGRKDVVEYLLQNGANVQARDDGGLI-PLHNACSFGHAEVVNLLLRHGADPNARDNW 123
Query: 113 GRLPVDLAEERGHRDV 128
P+ A +G DV
Sbjct: 124 NYTPLHEAAIKGKIDV 139
Score = 41.6 bits (96), Expect = 2e-04
Identities = 35/122 (28%), Positives = 56/122 (45%), Gaps = 5/122 (4%)
Query: 14 SDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGS---ARVAELLLLHGA 70
+D L AA G VE V++L + N + GR++ + V E LL HGA
Sbjct: 492 ADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGA 550
Query: 71 EPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAG 130
+ + D L P+H+A G + +L + GA ++V D W P+ A +G ++
Sbjct: 551 DVHAKDKGGLV-PLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICK 609
Query: 131 YL 132
L
Sbjct: 610 LL 611
Score = 40.8 bits (94), Expect = 4e-04
Identities = 36/139 (25%), Positives = 61/139 (43%), Gaps = 11/139 (7%)
Query: 6 KGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRF---GRRAIQVMMMGS---A 59
K + +G + L +A G EK+ LL P VN GR++ + +
Sbjct: 169 KAVLTGEYKKDELLESARSGNEEKMMALLT----PLNVNCHASDGRKSTPLHLAAGYNRV 224
Query: 60 RVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDL 119
++ +LLL HGA+ + D L P+H+A G + +L + GA ++ D W P+
Sbjct: 225 KIVQLLLQHGADVHAKDKGDLV-PLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHE 283
Query: 120 AEERGHRDVAGYLRTATGD 138
A + +V L + D
Sbjct: 284 AASKNRVEVCSLLLSYGAD 302
Score = 40.4 bits (93), Expect = 5e-04
Identities = 31/100 (31%), Positives = 48/100 (48%), Gaps = 2/100 (2%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARVAELLLLHGAEPNCADPAT 79
AA +E LL+ GAD N ++ G + G VA LL+ + A N D
Sbjct: 686 AAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWA 745
Query: 80 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDL 119
T P+H+AA++G +L GA +++ G+ P+DL
Sbjct: 746 FT-PLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784
Score = 35.8 bits (81), Expect = 0.012
Identities = 41/145 (28%), Positives = 59/145 (40%), Gaps = 33/145 (22%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELL------------ 65
L AA G ++ R LL G DPN ++ G A+Q MG+ V +LL
Sbjct: 437 LHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQ---MGNENVQQLLQEGISLGNSEAD 493
Query: 66 --LLHGAEP---------------NCAD-PATLTRPVHDAAREGFLDTLVVLHRAGARLD 107
LL A+ NC D + P+H AA + + L + GA +
Sbjct: 494 RQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVH 553
Query: 108 VRDAWGRLPVDLAEERGHRDVAGYL 132
+D G +P+ A GH +VA L
Sbjct: 554 AKDKGGLVPLHNACSYGHYEVAELL 578
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 55.5 bits (132), Expect = 1e-08
Identities = 42/124 (33%), Positives = 56/124 (45%), Gaps = 2/124 (1%)
Query: 10 SGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARVAELLLLH 68
S G L AA G VE V LL GA+ N ++ RRA+ MG V LL+ H
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Query: 69 GAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDV 128
GAE C D T P+H AA G ++ + L G +D + +G + +A G V
Sbjct: 171 GAEVTCKDKKGYT-PLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAV 229
Query: 129 AGYL 132
L
Sbjct: 230 VNEL 233
Score = 40.0 bits (92), Expect = 6e-04
Identities = 40/126 (31%), Positives = 56/126 (44%), Gaps = 11/126 (8%)
Query: 11 GGGSDEGLASAAARGLVEK-----VRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARVAEL 64
G D AR L EK + LL+ A+P+ ++ G +I G + EL
Sbjct: 466 GNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLEL 525
Query: 65 LLLH---GAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAE 121
LL G E + D P+H AA G L VL ++ LD+RD GR +DLA
Sbjct: 526 LLERTNSGFEES--DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAA 583
Query: 122 ERGHRD 127
+GH +
Sbjct: 584 FKGHTE 589
Score = 37.0 bits (84), Expect = 0.005
Identities = 31/111 (27%), Positives = 48/111 (43%), Gaps = 3/111 (2%)
Query: 30 VRQLLEAGADPNGVNRFGRRAIQVMMMGS--ARVAELLLLHGAEPNCADPATLTRPVHDA 87
V +L++ GA+ N N G + + A ELL+ +GA+ N + P+H
Sbjct: 230 VNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKS-PLHMT 288
Query: 88 AREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD 138
A G L + G +D D G P+ +A GH + LRT+ D
Sbjct: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339
Score = 37.0 bits (84), Expect = 0.005
Identities = 35/125 (28%), Positives = 53/125 (42%), Gaps = 4/125 (3%)
Query: 12 GGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGA 70
G + L AA G + + LL++ D + + GR A+ + G E L+ GA
Sbjct: 540 GATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGA 599
Query: 71 EPNCADPATLTRPVHDAAREGF---LDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRD 127
D T P+H + G L L+ + +DV+DA G+ P+ LA GH D
Sbjct: 600 SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659
Query: 128 VAGYL 132
L
Sbjct: 660 AVSLL 664
Score = 35.0 bits (79), Expect = 0.020
Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 2/91 (2%)
Query: 31 RQLLEAGADPNGVNRFGRRAIQVMMMG-SARVAELLLLHGAEPNCADPATLTRPVHDAAR 89
R+LL +G + + ++FGR + G + +LL GA+ + D T P+H AA
Sbjct: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRT-PLHYAAA 422
Query: 90 EGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
+ L GA ++ D WGR + A
Sbjct: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYA 453
Score = 30.4 bits (67), Expect = 0.49
Identities = 30/125 (24%), Positives = 53/125 (42%), Gaps = 8/125 (6%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADP 77
L A G + + L++ G + + V++ G + V +AR LL++ + AD
Sbjct: 285 LHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHV----AARYGHELLINTLRTSGADT 340
Query: 78 ATL----TRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLR 133
A P+H AA D L +G +D D +GR + A G+ + L+
Sbjct: 341 AKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQ 400
Query: 134 TATGD 138
++ D
Sbjct: 401 SSGAD 405
Score = 27.7 bits (60), Expect = 3.1
Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 63 ELLLLHGAEPNCADPATLTRPVHDA--AREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
+LLL H A N D + T + A + G +D LV + A A L V+D P+ LA
Sbjct: 831 QLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILV--NSAQADLTVKDKDLNTPLHLA 888
Query: 121 EERGHRDVA 129
+GH A
Sbjct: 889 CSKGHEKCA 897
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 54.7 bits (130), Expect = 2e-08
Identities = 39/119 (32%), Positives = 61/119 (51%), Gaps = 2/119 (1%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARVAELLLLHGAEPNCAD 76
L AA + + V +L+ A AD +++G+ A+ + +AR A LL GA+ + D
Sbjct: 1705 LMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQD 1764
Query: 77 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTA 135
T P+ AAREG ++ +L GA ++RD G P D+A +R H D+ L A
Sbjct: 1765 NREQT-PLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGA 1822
Score = 44.3 bits (103), Expect = 3e-05
Identities = 41/128 (32%), Positives = 54/128 (42%), Gaps = 1/128 (0%)
Query: 12 GGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSAR-VAELLLLHGA 70
G + L AA R+LLEAGA+PN +R GR + + AR V +LLL
Sbjct: 1632 GTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQ 1691
Query: 71 EPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAG 130
A T P+ AAR D + L A A + RD WG+ + A + A
Sbjct: 1692 TAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAAR 1751
Query: 131 YLRTATGD 138
L A D
Sbjct: 1752 SLLQAGAD 1759
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 54.7 bits (130), Expect = 2e-08
Identities = 42/115 (36%), Positives = 57/115 (49%), Gaps = 2/115 (1%)
Query: 15 DEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAI-QVMMMGSARVAELLLLHGAEPN 73
+ L +AA RG +E R LLE GA NR G + + G ++ +LLL HGA+ N
Sbjct: 1035 ETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVN 1094
Query: 74 CADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDV 128
AD T P+ AA EG L T+ L GA + + D G + A +GH V
Sbjct: 1095 MADKQGRT-PLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSV 1148
Score = 36.6 bits (83), Expect = 0.007
Identities = 25/77 (32%), Positives = 41/77 (53%), Gaps = 1/77 (1%)
Query: 56 MGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRL 115
+G + LLL GA + + + LT P+ AA G+L +V+L + A++D D G+
Sbjct: 895 LGYTEMVALLLEFGANVDASSESGLT-PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQC 953
Query: 116 PVDLAEERGHRDVAGYL 132
+ A RGH +V +L
Sbjct: 954 ALVHAALRGHLEVVKFL 970
Score = 34.3 bits (77), Expect = 0.034
Identities = 36/131 (27%), Positives = 53/131 (40%), Gaps = 18/131 (13%)
Query: 16 EGLASAAARGLVEKVRQLL------EAGADPNGVNRF----GRRAIQVMM-MGSARVAEL 64
+ L +AA+ G E V LL E + +N F G A+ G V L
Sbjct: 993 QALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRL 1052
Query: 65 LLLHGA---EPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAE 121
LL GA +PN P+ R+G + +L GA +++ D GR P+ +A
Sbjct: 1053 LLEQGAAVAQPNRRGAV----PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAA 1108
Query: 122 ERGHRDVAGYL 132
GH +L
Sbjct: 1109 SEGHLGTVDFL 1119
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 53.9 bits (128), Expect = 4e-08
Identities = 39/116 (33%), Positives = 58/116 (50%), Gaps = 2/116 (1%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMG-SARVAELLLLHGAEPNCAD 76
L +A+ARG + V L E GAD N ++ G A+ + + V + LL G + D
Sbjct: 515 LLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQD 574
Query: 77 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
T P+H A ++G + +V L A LD+ + +GR P+ LA G DV YL
Sbjct: 575 RHGNT-PLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYL 629
Score = 43.5 bits (101), Expect = 6e-05
Identities = 30/95 (31%), Positives = 47/95 (49%), Gaps = 2/95 (2%)
Query: 39 DPNGVNRFGRRAIQVMM-MGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLV 97
D N N+ G + + G+ ++ +LL+ G+ + D + V+ AAR G +DTL
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGG-SNAVYWAARHGHVDTLK 429
Query: 98 VLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
L LDV+D G + + +A GH DVA L
Sbjct: 430 FLSENKCPLDVKDKSGEMALHVAARYGHADVAQLL 464
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 53.9 bits (128), Expect = 4e-08
Identities = 38/111 (34%), Positives = 57/111 (51%), Gaps = 2/111 (1%)
Query: 12 GGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARVAELLLLHGA 70
G L AA G + V LL+ GA+ + + G + G A V LLL GA
Sbjct: 214 GRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGA 273
Query: 71 EPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAE 121
+PN D T P+H+AA +G +D +VL + GA ++R+ G+ +DLA+
Sbjct: 274 DPNARDNWNYT-PLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLAD 323
Score = 50.4 bits (119), Expect = 5e-07
Identities = 40/114 (35%), Positives = 56/114 (49%), Gaps = 3/114 (2%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARVAELLLLHGAEPNCADPAT 79
AA V V LL GAD + ++ G + G VAELL+ HGA N AD
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
Query: 80 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLR 133
T P+H+AA +G + +L + GA ++ G P+DL +E G D+ LR
Sbjct: 751 FT-PLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR 802
Score = 48.5 bits (114), Expect = 2e-06
Identities = 40/136 (29%), Positives = 59/136 (43%), Gaps = 21/136 (15%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELL-----LLHGAEP 72
L AAA+G E + LL+ GADP NR G + ++ G + +LL LL A+
Sbjct: 754 LHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKK 813
Query: 73 NC-------ADPATL---------TRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP 116
C P + + P+H AA L+ L GA ++ +D G +P
Sbjct: 814 GCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIP 873
Query: 117 VDLAEERGHRDVAGYL 132
+ A GH D+A L
Sbjct: 874 LHNAASYGHVDIAALL 889
Score = 47.0 bits (110), Expect = 5e-06
Identities = 35/124 (28%), Positives = 57/124 (45%), Gaps = 11/124 (8%)
Query: 15 DEGLASAAARGLVEKVRQLLEAGADPNGVN---RFGRRAIQVMMMG---SARVAELLLLH 68
D L AA +G + +V++L P +N GR + + + + VAE LL H
Sbjct: 804 DAALLDAAKKGCLARVQKL----CTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEH 859
Query: 69 GAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDV 128
GA+ N D L P+H+AA G +D +L + ++ D W P+ A ++G +
Sbjct: 860 GADVNAQDKGGLI-PLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQL 918
Query: 129 AGYL 132
L
Sbjct: 919 CALL 922
Score = 46.6 bits (109), Expect = 7e-06
Identities = 38/125 (30%), Positives = 60/125 (48%), Gaps = 5/125 (4%)
Query: 7 GMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM---MGSARVAE 63
G+P+ G+ L A G V +V++L++A A+ N + GR++ + G V E
Sbjct: 175 GVPAVSGALRELLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVE 233
Query: 64 LLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEER 123
LL GA + D L P+H+A G + + +L GA + RD W P+ A +
Sbjct: 234 HLLQMGANVHARDDGGLI-PLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIK 292
Query: 124 GHRDV 128
G DV
Sbjct: 293 GKIDV 297
Score = 42.7 bits (99), Expect = 9e-05
Identities = 38/139 (27%), Positives = 61/139 (43%), Gaps = 11/139 (7%)
Query: 6 KGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRF---GRRAIQVMMMGS---A 59
K + +G + L AA G EK+ LL P VN GR++ + +
Sbjct: 327 KAVLTGEYKKDELLEAARSGNEEKLMALLT----PLNVNCHASDGRKSTPLHLAAGYNRV 382
Query: 60 RVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDL 119
R+ +LLL HGA+ + D L P+H+A G + +L + GA ++ D W P+
Sbjct: 383 RIVQLLLQHGADVHAKDKGGLV-PLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHE 441
Query: 120 AEERGHRDVAGYLRTATGD 138
A + +V L + D
Sbjct: 442 AASKNRVEVCSLLLSHGAD 460
Score = 42.4 bits (98), Expect = 1e-04
Identities = 35/121 (28%), Positives = 55/121 (45%), Gaps = 5/121 (4%)
Query: 15 DEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGS---ARVAELLLLHGAE 71
D L A+ G +E V+QL + + N + GR + + V E LL HGA+
Sbjct: 651 DYRLLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGAD 709
Query: 72 PNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGY 131
+ D L P+H+A G + +L R GA ++V D W P+ A +G ++
Sbjct: 710 VHAKDKGGLV-PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKL 768
Query: 132 L 132
L
Sbjct: 769 L 769
Score = 42.0 bits (97), Expect = 2e-04
Identities = 33/110 (30%), Positives = 51/110 (46%), Gaps = 2/110 (1%)
Query: 12 GGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARVAELLLLHGA 70
G + L AA +E LLE GAD N ++ G + G +A LL+ +
Sbjct: 835 GRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNT 894
Query: 71 EPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
N D T P+H+AA++G +L GA +++ G+ P+DLA
Sbjct: 895 CVNATDKWAFT-PLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 41.2 bits (95), Expect = 3e-04
Identities = 36/112 (32%), Positives = 52/112 (46%), Gaps = 2/112 (1%)
Query: 10 SGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARVAELLLLH 68
S G L AA V V+ LL+ GAD + ++ G + G V ELLL H
Sbjct: 365 SDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 424
Query: 69 GAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
GA N D T P+H+AA + ++ +L GA + + G+ VD+A
Sbjct: 425 GACVNAMDLWQFT-PLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 39.7 bits (91), Expect = 8e-04
Identities = 24/66 (36%), Positives = 35/66 (53%), Gaps = 1/66 (1%)
Query: 60 RVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDL 119
+V ELLL GA N + +T P+H AA D + VLH+ GA+++ D G+ +
Sbjct: 539 QVTELLLRKGANVNEKNKDFMT-PLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHR 597
Query: 120 AEERGH 125
A GH
Sbjct: 598 AALAGH 603
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 53.9 bits (128), Expect = 4e-08
Identities = 44/121 (36%), Positives = 59/121 (48%), Gaps = 7/121 (5%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM------GSARVAELLLLHGAE 71
L +AA G E V LL+ GA+ N + GR A+ V + G A V LL+ GAE
Sbjct: 681 LIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE 740
Query: 72 PNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGY 131
+ D +T P+ AA EG +D + +L GA +D D GR P+ A GH V
Sbjct: 741 VDHCDKDGMT-PLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNT 799
Query: 132 L 132
L
Sbjct: 800 L 800
Score = 50.1 bits (118), Expect = 6e-07
Identities = 39/111 (35%), Positives = 52/111 (46%), Gaps = 2/111 (1%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSARVAELLLLHGAEPNCAD 76
L +AA+ G V LL GA + ++ GR + + G+ V LL G + N D
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844
Query: 77 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRD 127
A T P+H AA EG L GAR + D GR+P LA + GH D
Sbjct: 845 DAGWT-PLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYD 894
Score = 46.6 bits (109), Expect = 7e-06
Identities = 35/108 (32%), Positives = 55/108 (50%), Gaps = 6/108 (5%)
Query: 24 RGLVEKVRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARVAELLLLHGA--EPNCADPATL 80
+G +E V+ L+ AD N + R A+Q G +V +LL+ HGA + C AT
Sbjct: 989 QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATA 1048
Query: 81 TRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDV 128
+ AA+EG +D + VL GA + D +GR + +A + GH +
Sbjct: 1049 ---LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQI 1093
Score = 44.7 bits (104), Expect = 2e-05
Identities = 37/116 (31%), Positives = 55/116 (47%), Gaps = 2/116 (1%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCAD 76
L+ A+A+G VE VR LL+ G D N + G + + G + E L+ GA N D
Sbjct: 818 LSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEID 877
Query: 77 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
P A++EG D + +L + +D R GR + +A GHRD+ L
Sbjct: 878 NDGRI-PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELL 932
Score = 41.6 bits (96), Expect = 2e-04
Identities = 28/70 (40%), Positives = 41/70 (58%), Gaps = 6/70 (8%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEP-NCA 75
L AA G ++ V+ LLE GADPN ++FGR A++V G +++ +LL +GA N
Sbjct: 1049 LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGC 1108
Query: 76 DPATLTRPVH 85
P+ PVH
Sbjct: 1109 SPS----PVH 1114
Score = 39.3 bits (90), Expect = 0.001
Identities = 33/113 (29%), Positives = 54/113 (47%), Gaps = 2/113 (1%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCADPAT 79
A+ G + V+ LLE ++ + GR A++V + G + ELL HGA+ NC D A
Sbjct: 887 ASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKD-AD 945
Query: 80 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
++ A E L GA ++ DA GR + ++ +GH ++ L
Sbjct: 946 GRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
Score = 38.9 bits (89), Expect = 0.001
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 2/88 (2%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCAD 76
L SAA +G V+ V+ L+E GA + G A+ + G V ++LL HGA+PN AD
Sbjct: 1016 LQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHAD 1075
Query: 77 PATLTRPVHDAAREGFLDTLVVLHRAGA 104
T + AA+ G + +L + GA
Sbjct: 1076 QFGRT-AMRVAAKNGHSQIIKLLEKYGA 1102
Score = 36.2 bits (82), Expect = 0.009
Identities = 36/123 (29%), Positives = 53/123 (43%), Gaps = 5/123 (4%)
Query: 14 SDEGLASAAARGLVEK---VRQLLEAGADPNGVNRFGRRAI-QVMMMGSARVAELLLLHG 69
S++ S R +E+ +R LL+ GA N + GR + GS V LL+ G
Sbjct: 509 SEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRG 568
Query: 70 AEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVA 129
A+ D T P+ AAR+G + L GA ++ D G + A GH +V
Sbjct: 569 ADLEIEDAHGHT-PLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVV 627
Query: 130 GYL 132
L
Sbjct: 628 SAL 630
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 53.5 bits (127), Expect = 5e-08
Identities = 45/127 (35%), Positives = 61/127 (48%), Gaps = 4/127 (3%)
Query: 15 DEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSARVAELLLLHGAEPN 73
+ L AA G VE VR LL GA + R + + + +G + +LLL H A P+
Sbjct: 444 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 503
Query: 74 CADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL- 132
A T P+H +AREG +D VL AGA + G P+ +A + G DVA L
Sbjct: 504 AATTNGYT-PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562
Query: 133 -RTATGD 138
R A D
Sbjct: 563 QRRAAAD 569
Score = 43.5 bits (101), Expect = 6e-05
Identities = 34/120 (28%), Positives = 57/120 (47%), Gaps = 2/120 (1%)
Query: 14 SDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEP 72
S+ AA G ++KV + L+ G D N N+ G A+ + G + + LL G+
Sbjct: 10 SNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSV 69
Query: 73 NCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
+ A T +H A+ G + + VL + GA ++ + G P+ +A + H DV YL
Sbjct: 70 DSATKKGNT-ALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128
Score = 41.2 bits (95), Expect = 3e-04
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 2/101 (1%)
Query: 33 LLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCADPATLTRPVHDAAREG 91
LLE GA P+ + G + + ++A LL +GAE N +T P+H A++EG
Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT-PLHLASQEG 652
Query: 92 FLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
D + +L GA + + G + LA + +VA L
Sbjct: 653 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 693
Score = 40.0 bits (92), Expect = 6e-04
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 2/113 (1%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSARVAELLLLHGAEPNCADPAT 79
AA G ++ + LL+ A + + G + V + +VA LLL GA P+
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
Query: 80 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
T P+H AA++ + L GA ++ G P+ LA + GH D+ L
Sbjct: 609 YT-PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Score = 39.3 bits (90), Expect = 0.001
Identities = 37/136 (27%), Positives = 58/136 (42%), Gaps = 5/136 (3%)
Query: 5 NKGMPSGGGSDEGLAS---AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSAR 60
+KG + GL S AA V L + GAD + + G + V G+ +
Sbjct: 662 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 721
Query: 61 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
+ LL GA N T P+H AA++G + VL + GA+ + A G + +A
Sbjct: 722 MVNFLLKQGANVNAKTKNGYT-PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780
Query: 121 EERGHRDVAGYLRTAT 136
+ G+ V L+ T
Sbjct: 781 KRLGYISVVDTLKVVT 796
Score = 34.7 bits (78), Expect = 0.026
Identities = 34/113 (30%), Positives = 49/113 (43%), Gaps = 2/113 (1%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCADPAT 79
AA G V LL GA + R G + V G+ + +LLL G + +
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
Query: 80 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
LT P+H AAR G + +L GA L R G P+ +A + H + +L
Sbjct: 279 LT-PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 330
Score = 27.7 bits (60), Expect = 3.1
Identities = 15/50 (30%), Positives = 26/50 (52%)
Query: 83 PVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
P+H AA G ++ +L GA +D G P+ +A +RG+ ++ L
Sbjct: 215 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 53.5 bits (127), Expect = 5e-08
Identities = 45/127 (35%), Positives = 61/127 (48%), Gaps = 4/127 (3%)
Query: 15 DEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSARVAELLLLHGAEPN 73
+ L AA G VE VR LL GA + R + + + +G + +LLL H A P+
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
Query: 74 CADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL- 132
A T P+H +AREG +D VL AGA + G P+ +A + G DVA L
Sbjct: 525 AATTNGYT-PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 133 -RTATGD 138
R A D
Sbjct: 584 QRRAAAD 590
Score = 45.4 bits (106), Expect = 1e-05
Identities = 35/130 (26%), Positives = 60/130 (46%), Gaps = 2/130 (1%)
Query: 4 ENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVA 62
+ + P S+ AA G ++KV + L+ G D N N+ G A+ + G +
Sbjct: 21 QRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLV 80
Query: 63 ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE 122
+ LL G+ + A T +H A+ G + + VL + GA ++ + G P+ +A +
Sbjct: 81 QELLGRGSSVDSATKKGNT-ALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ 139
Query: 123 RGHRDVAGYL 132
H DV YL
Sbjct: 140 ENHIDVVKYL 149
Score = 41.2 bits (95), Expect = 3e-04
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 2/101 (1%)
Query: 33 LLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCADPATLTRPVHDAAREG 91
LLE GA P+ + G + + ++A LL +GAE N +T P+H A++EG
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT-PLHLASQEG 673
Query: 92 FLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
D + +L GA + + G + LA + +VA L
Sbjct: 674 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 40.0 bits (92), Expect = 6e-04
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 2/113 (1%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSARVAELLLLHGAEPNCADPAT 79
AA G ++ + LL+ A + + G + V + +VA LLL GA P+
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 80 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
T P+H AA++ + L GA ++ G P+ LA + GH D+ L
Sbjct: 630 YT-PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 39.3 bits (90), Expect = 0.001
Identities = 37/136 (27%), Positives = 58/136 (42%), Gaps = 5/136 (3%)
Query: 5 NKGMPSGGGSDEGLAS---AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSAR 60
+KG + GL S AA V L + GAD + + G + V G+ +
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742
Query: 61 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
+ LL GA N T P+H AA++G + VL + GA+ + A G + +A
Sbjct: 743 MVNFLLKQGANVNAKTKNGYT-PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Query: 121 EERGHRDVAGYLRTAT 136
+ G+ V L+ T
Sbjct: 802 KRLGYISVVDTLKVVT 817
Score = 34.7 bits (78), Expect = 0.026
Identities = 34/113 (30%), Positives = 49/113 (43%), Gaps = 2/113 (1%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCADPAT 79
AA G V LL GA + R G + V G+ + +LLL G + +
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 80 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
LT P+H AAR G + +L GA L R G P+ +A + H + +L
Sbjct: 300 LT-PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Score = 27.7 bits (60), Expect = 3.1
Identities = 15/50 (30%), Positives = 26/50 (52%)
Query: 83 PVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
P+H AA G ++ +L GA +D G P+ +A +RG+ ++ L
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 53.5 bits (127), Expect = 5e-08
Identities = 45/127 (35%), Positives = 61/127 (48%), Gaps = 4/127 (3%)
Query: 15 DEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSARVAELLLLHGAEPN 73
+ L AA G VE VR LL GA + R + + + +G + +LLL H A P+
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
Query: 74 CADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL- 132
A T P+H +AREG +D VL AGA + G P+ +A + G DVA L
Sbjct: 525 AATTNGYT-PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 133 -RTATGD 138
R A D
Sbjct: 584 QRRAAAD 590
Score = 45.4 bits (106), Expect = 1e-05
Identities = 35/130 (26%), Positives = 60/130 (46%), Gaps = 2/130 (1%)
Query: 4 ENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVA 62
+ + P S+ AA G ++KV + L+ G D N N+ G A+ + G +
Sbjct: 21 QRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLV 80
Query: 63 ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE 122
+ LL G+ + A T +H A+ G + + VL + GA ++ + G P+ +A +
Sbjct: 81 QELLGRGSSVDSATKKGNT-ALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ 139
Query: 123 RGHRDVAGYL 132
H DV YL
Sbjct: 140 ENHIDVVKYL 149
Score = 41.2 bits (95), Expect = 3e-04
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 2/101 (1%)
Query: 33 LLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCADPATLTRPVHDAAREG 91
LLE GA P+ + G + + ++A LL +GAE N +T P+H A++EG
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT-PLHLASQEG 673
Query: 92 FLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
D + +L GA + + G + LA + +VA L
Sbjct: 674 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 40.0 bits (92), Expect = 6e-04
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 2/113 (1%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSARVAELLLLHGAEPNCADPAT 79
AA G ++ + LL+ A + + G + V + +VA LLL GA P+
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 80 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
T P+H AA++ + L GA ++ G P+ LA + GH D+ L
Sbjct: 630 YT-PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 39.3 bits (90), Expect = 0.001
Identities = 37/136 (27%), Positives = 58/136 (42%), Gaps = 5/136 (3%)
Query: 5 NKGMPSGGGSDEGLAS---AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSAR 60
+KG + GL S AA V L + GAD + + G + V G+ +
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742
Query: 61 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
+ LL GA N T P+H AA++G + VL + GA+ + A G + +A
Sbjct: 743 MVNFLLKQGANVNAKTKNGYT-PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Query: 121 EERGHRDVAGYLRTAT 136
+ G+ V L+ T
Sbjct: 802 KRLGYISVVDTLKVVT 817
Score = 34.7 bits (78), Expect = 0.026
Identities = 34/113 (30%), Positives = 49/113 (43%), Gaps = 2/113 (1%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCADPAT 79
AA G V LL GA + R G + V G+ + +LLL G + +
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 80 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
LT P+H AAR G + +L GA L R G P+ +A + H + +L
Sbjct: 300 LT-PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Score = 27.7 bits (60), Expect = 3.1
Identities = 15/50 (30%), Positives = 26/50 (52%)
Query: 83 PVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
P+H AA G ++ +L GA +D G P+ +A +RG+ ++ L
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 53.5 bits (127), Expect = 5e-08
Identities = 40/109 (36%), Positives = 53/109 (48%), Gaps = 1/109 (0%)
Query: 10 SGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSARVAELLLLH 68
S G L A A G V LL AGADPN ++ G+R + + G+ AELLL
Sbjct: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248
Query: 69 GAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV 117
GA + P+H AAR G ++ +L R GA D R+A G P+
Sbjct: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 297
Score = 31.2 bits (69), Expect = 0.28
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 15/114 (13%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAI--------------QVMMMGSARVAELLL 66
AA G VE LL GA P+ N G + + ++ LLL
Sbjct: 267 AARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLL 326
Query: 67 LHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
GA+ + AD RP+H A R G + +L G + D G P+ A
Sbjct: 327 SAGADADAADQDK-QRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
Score = 28.5 bits (62), Expect = 1.8
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 2/76 (2%)
Query: 57 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP 116
G V LLL A P+ A P T +H+A G + VL AGA ++ D G+ P
Sbjct: 172 GHTEVLRLLLRRRARPDSA-PGGRTA-LHEACAAGHTACVHVLLVAGADPNIADQDGKRP 229
Query: 117 VDLAEERGHRDVAGYL 132
+ L G + A L
Sbjct: 230 LHLCRGPGTLECAELL 245
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 53.5 bits (127), Expect = 5e-08
Identities = 40/109 (36%), Positives = 53/109 (48%), Gaps = 1/109 (0%)
Query: 10 SGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSARVAELLLLH 68
S G L A A G V LL AGADPN ++ G+R + + G+ AELLL
Sbjct: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248
Query: 69 GAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV 117
GA + P+H AAR G ++ +L R GA D R+A G P+
Sbjct: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 297
Score = 31.2 bits (69), Expect = 0.28
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 15/114 (13%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAI--------------QVMMMGSARVAELLL 66
AA G VE LL GA P+ N G + + ++ LLL
Sbjct: 267 AARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLL 326
Query: 67 LHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
GA+ + AD RP+H A R G + +L G + D G P+ A
Sbjct: 327 SAGADADAADQDK-QRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
Score = 28.5 bits (62), Expect = 1.8
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 2/76 (2%)
Query: 57 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP 116
G V LLL A P+ A P T +H+A G + VL AGA ++ D G+ P
Sbjct: 172 GHTEVLRLLLRRRARPDSA-PGGRTA-LHEACAAGHTACVHVLLVAGADPNIADQDGKRP 229
Query: 117 VDLAEERGHRDVAGYL 132
+ L G + A L
Sbjct: 230 LHLCRGPGTLECAELL 245
>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
[Homo sapiens]
Length = 452
Score = 53.5 bits (127), Expect = 5e-08
Identities = 40/109 (36%), Positives = 53/109 (48%), Gaps = 1/109 (0%)
Query: 10 SGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSARVAELLLLH 68
S G L A A G V LL AGADPN ++ G+R + + G+ AELLL
Sbjct: 129 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 188
Query: 69 GAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV 117
GA + P+H AAR G ++ +L R GA D R+A G P+
Sbjct: 189 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 237
Score = 31.2 bits (69), Expect = 0.28
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 15/114 (13%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAI--------------QVMMMGSARVAELLL 66
AA G VE LL GA P+ N G + + ++ LLL
Sbjct: 207 AARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLL 266
Query: 67 LHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
GA+ + AD RP+H A R G + +L G + D G P+ A
Sbjct: 267 SAGADADAADQDK-QRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
Score = 28.5 bits (62), Expect = 1.8
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 2/76 (2%)
Query: 57 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP 116
G V LLL A P+ A P T +H+A G + VL AGA ++ D G+ P
Sbjct: 112 GHTEVLRLLLRRRARPDSA-PGGRTA-LHEACAAGHTACVHVLLVAGADPNIADQDGKRP 169
Query: 117 VDLAEERGHRDVAGYL 132
+ L G + A L
Sbjct: 170 LHLCRGPGTLECAELL 185
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 53.5 bits (127), Expect = 5e-08
Identities = 39/113 (34%), Positives = 57/113 (50%), Gaps = 2/113 (1%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMG-SARVAELLLLHGAEPNCADPAT 79
AA++GL E + LL GAD N N G A+ + + + ++LL HGA + D A
Sbjct: 61 AASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVD-AE 119
Query: 80 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
P+H AA G ++++L A LDV D GR P+ +A GH + L
Sbjct: 120 NRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQL 172
Score = 33.5 bits (75), Expect = 0.057
Identities = 21/46 (45%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 32 QLLEAGADPNGVNRFGRRA-IQVMMMGSARVAELLLLHGAEPNCAD 76
QLL+ GA N ++ + A I GSA VAELLL HGA+ D
Sbjct: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVD 216
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 52.8 bits (125), Expect = 9e-08
Identities = 41/115 (35%), Positives = 53/115 (46%), Gaps = 6/115 (5%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGA--EPNCADP 77
AA G V V QL+ GA PN N G A+ + G A V L+ GA E D
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
Query: 78 ATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
T P+H +AR G D + L + GA + G P+ L+ GH DVA +L
Sbjct: 500 QT---PLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFL 551
Score = 52.0 bits (123), Expect = 2e-07
Identities = 38/119 (31%), Positives = 56/119 (47%), Gaps = 2/119 (1%)
Query: 15 DEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSARVAELLLLHGAEPN 73
+ L AA G E VR L++ GA + + + + +G A + + LL GA PN
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526
Query: 74 CADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
A + T P+H +AREG D L GA L + G P+ +A + G +VA L
Sbjct: 527 AATTSGYT-PLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL 584
Score = 47.0 bits (110), Expect = 5e-06
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 2/113 (1%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCADPAT 79
AA + ++ LLE GAD N V R G ++ + G + LLL A N ++ +
Sbjct: 638 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697
Query: 80 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
LT P+H AA+E ++ VL GA +D + G P+ + G+ + +L
Sbjct: 698 LT-PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
Score = 45.8 bits (107), Expect = 1e-05
Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 2/113 (1%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMM-MGSARVAELLLLHGAEPNCADPAT 79
AA G +E LL+ A P+ + G + V + +VA LLL GA P+ A
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631
Query: 80 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
T P+H AA++ +D L GA + G V LA + GH D+ L
Sbjct: 632 YT-PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683
Score = 39.7 bits (91), Expect = 8e-04
Identities = 33/113 (29%), Positives = 51/113 (45%), Gaps = 2/113 (1%)
Query: 21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSA-RVAELLLLHGAEPNCADPAT 79
AA G + + LL+ A+PN G + + + +V ELLL HGA +
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
Query: 80 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
LT P+H AA G ++ + L GA + + G + +A G +V YL
Sbjct: 434 LT-PIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Score = 37.0 bits (84), Expect = 0.005
Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 2/101 (1%)
Query: 33 LLEAGADPNGVNRFGRRAIQVMMMGSAR-VAELLLLHGAEPNCADPATLTRPVHDAAREG 91
LL+ GA P+ + G + + + +A LL +GA+ N + VH AA+EG
Sbjct: 617 LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIAS-VHLAAQEG 675
Query: 92 FLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
+D + +L A +++ + G P+ LA + +VA L
Sbjct: 676 HVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
Score = 36.2 bits (82), Expect = 0.009
Identities = 32/132 (24%), Positives = 56/132 (42%), Gaps = 2/132 (1%)
Query: 2 REENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSAR 60
R+ ++ ++ AA G +EK ++ G D N N+ G A+ + G
Sbjct: 29 RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88
Query: 61 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 120
V LL A + A T +H A+ G + + VL GA ++ + G P+ +A
Sbjct: 89 VVSELLQREANVDAATKKGNT-ALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMA 147
Query: 121 EERGHRDVAGYL 132
+ H +V +L
Sbjct: 148 AQENHLEVVKFL 159
Score = 32.3 bits (72), Expect = 0.13
Identities = 22/76 (28%), Positives = 35/76 (46%), Gaps = 1/76 (1%)
Query: 57 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP 116
G+ VA LLL A + +T P+H A++ G + + +L GA++D + G P
Sbjct: 246 GNINVATLLLNRAAAVDFTARNDIT-PLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTP 304
Query: 117 VDLAEERGHRDVAGYL 132
+ GH V L
Sbjct: 305 LHCGARSGHEQVVEML 320
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 51.6 bits (122), Expect = 2e-07
Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 5/115 (4%)
Query: 19 ASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARVAELLLLHGAEPNCADP 77
A A G++E L+ + AD N V+ G+ A+ + + A +LL +GA + +
Sbjct: 2003 ARLAVEGMLE---DLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNN 2059
Query: 78 ATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
T P+ AAREG +T VL A D+ D RLP D+A+ER H D+ L
Sbjct: 2060 REET-PLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLL 2113
Score = 29.3 bits (64), Expect = 1.1
Identities = 27/90 (30%), Positives = 42/90 (46%), Gaps = 4/90 (4%)
Query: 15 DEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSAR-VAELLLLHGAEPN 73
+ L AA + ++LLEA AD N + GR + + A+ V ++L+ + A
Sbjct: 1929 ETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATDL 1988
Query: 74 CADPATLTRPVHDAAR---EGFLDTLVVLH 100
A T P+ AAR EG L+ L+ H
Sbjct: 1989 DARMHDGTTPLILAARLAVEGMLEDLINSH 2018
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 51.6 bits (122), Expect = 2e-07
Identities = 35/78 (44%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 57 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP 116
G +V LLLHG E + AD T P+HDAA G L+ +L GA LDVRD G
Sbjct: 251 GHTKVLSWLLLHGGEIS-ADLWGGT-PLHDAAENGELECCQILVVNGAELDVRDRDGYTA 308
Query: 117 VDLAEERGHRDVAGYLRT 134
DL++ GH YLRT
Sbjct: 309 ADLSDFNGHSHCTRYLRT 326
Score = 32.7 bits (73), Expect = 0.098
Identities = 23/77 (29%), Positives = 32/77 (41%), Gaps = 1/77 (1%)
Query: 57 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLV-VLHRAGARLDVRDAWGRL 115
G L+ A P A P HDA+ G L L +L + G R+ +D G
Sbjct: 47 GKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGAT 106
Query: 116 PVDLAEERGHRDVAGYL 132
+ LA GH +V +L
Sbjct: 107 VLHLAARFGHPEVVNWL 123
Score = 29.6 bits (65), Expect = 0.83
Identities = 24/79 (30%), Positives = 34/79 (43%), Gaps = 5/79 (6%)
Query: 57 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVL---HRAGARLDVRDAWG 113
G V LL HG A P+H AA +G +L +L + G ++ G
Sbjct: 115 GHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKN--G 172
Query: 114 RLPVDLAEERGHRDVAGYL 132
P+ LA + GH +V YL
Sbjct: 173 ATPLYLACQEGHLEVTQYL 191
Score = 26.2 bits (56), Expect = 9.2
Identities = 18/39 (46%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 87 AAREGFLDTLVVLHRAG-ARLDVRDAWGRLPVDLAEERG 124
AAR+G LD L LH AG +RD LPV A G
Sbjct: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAG 47
>gi|98985804 cyclin-dependent kinase inhibitor 2A isoform 3 [Homo
sapiens]
Length = 116
Score = 51.2 bits (121), Expect = 3e-07
Identities = 30/49 (61%), Positives = 34/49 (69%), Gaps = 4/49 (8%)
Query: 9 PSGGGSDEG----LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQV 53
P+ G S E LA+AAARG VE+VR LLEAGA PN N +GRR IQV
Sbjct: 3 PAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV 51
>gi|14249672 protein phosphatase 1, regulatory (inhibitor) subunit
16A [Homo sapiens]
Length = 528
Score = 50.8 bits (120), Expect = 3e-07
Identities = 42/122 (34%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Query: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSAR-VAELLLLHGAEPNCAD 76
L AAAR +E+VRQ L +G P+ N G A+ + R + + LL GA N D
Sbjct: 75 LLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACD 134
Query: 77 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTAT 136
T P+H AA G L + +L +GA L + G +P DL ++ D L TA
Sbjct: 135 SECWT-PLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDC---LETAM 190
Query: 137 GD 138
D
Sbjct: 191 AD 192
Score = 33.1 bits (74), Expect = 0.075
Identities = 27/95 (28%), Positives = 44/95 (46%), Gaps = 2/95 (2%)
Query: 26 LVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCADPATLTRPV 84
+++ +R L+AGAD + G + V G + A LLL H A + D P+
Sbjct: 211 MLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDG-WEPL 269
Query: 85 HDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDL 119
H AA G + + +L GA L+ + P+D+
Sbjct: 270 HAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDV 304
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 4,999,740
Number of Sequences: 37866
Number of extensions: 193374
Number of successful extensions: 1497
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 195
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 640
Number of HSP's gapped (non-prelim): 744
length of query: 138
length of database: 18,247,518
effective HSP length: 91
effective length of query: 47
effective length of database: 14,801,712
effective search space: 695680464
effective search space used: 695680464
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 56 (26.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.