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Search of human proteins with 17318565
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|17318565 cyclin E2 [Homo sapiens]
(404 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|17318565 cyclin E2 [Homo sapiens] 822 0.0
gi|17318559 cyclin E1 isoform 1 [Homo sapiens] 364 e-101
gi|17318561 cyclin E1 isoform 2 [Homo sapiens] 364 e-101
gi|161377472 cyclin A1 isoform c [Homo sapiens] 103 4e-22
gi|161377470 cyclin A1 isoform c [Homo sapiens] 103 4e-22
gi|161377468 cyclin A1 isoform b [Homo sapiens] 103 4e-22
gi|4502611 cyclin A1 isoform a [Homo sapiens] 103 4e-22
gi|4502613 cyclin A [Homo sapiens] 100 3e-21
gi|4757930 cyclin B2 [Homo sapiens] 99 7e-21
gi|14327896 cyclin B1 [Homo sapiens] 97 3e-20
gi|16950655 cyclin D1 [Homo sapiens] 93 4e-19
gi|4502617 cyclin D2 [Homo sapiens] 89 9e-18
gi|4502619 cyclin D3 isoform 2 [Homo sapiens] 86 5e-17
gi|90669307 cyclin B3 isoform 3 [Homo sapiens] 77 2e-14
gi|5802992 cyclin I [Homo sapiens] 74 2e-13
gi|153791755 cyclin domain containing [Homo sapiens] 62 9e-10
gi|242247025 cyclin N-terminal domain containing 2 isoform 2 [Ho... 61 2e-09
gi|89886237 cyclin I family, member 2 [Homo sapiens] 59 1e-08
gi|16306525 cyclin B3 isoform 1 [Homo sapiens] 56 7e-08
gi|4757936 cyclin G2 [Homo sapiens] 54 3e-07
gi|118572588 cyclin F [Homo sapiens] 52 1e-06
gi|197276674 cyclin J isoform 1 [Homo sapiens] 49 6e-06
gi|209862835 cyclin D3 isoform 1 [Homo sapiens] 48 1e-05
gi|40254889 cyclin J isoform 2 [Homo sapiens] 47 2e-05
gi|40805832 cyclin G1 [Homo sapiens] 47 4e-05
gi|4757934 cyclin G1 [Homo sapiens] 47 4e-05
gi|197276676 cyclin J isoform 3 [Homo sapiens] 47 4e-05
gi|94680985 cyclin J-like [Homo sapiens] 36 0.071
gi|209915553 cyclin D3 isoform 3 [Homo sapiens] 35 0.12
gi|187173292 troponin T1, skeletal, slow isoform c [Homo sapiens] 33 0.60
>gi|17318565 cyclin E2 [Homo sapiens]
Length = 404
Score = 822 bits (2124), Expect = 0.0
Identities = 404/404 (100%), Positives = 404/404 (100%)
Query: 1 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP 60
MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP
Sbjct: 1 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP 60
Query: 61 VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK 120
VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK
Sbjct: 61 VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK 120
Query: 121 ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI 180
ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI
Sbjct: 121 ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI 180
Query: 181 NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP 240
NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP
Sbjct: 181 NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP 240
Query: 241 VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA 300
VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA
Sbjct: 241 VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA 300
Query: 301 LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH 360
LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH
Sbjct: 301 LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH 360
Query: 361 TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH 404
TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH
Sbjct: 361 TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH 404
>gi|17318559 cyclin E1 isoform 1 [Homo sapiens]
Length = 410
Score = 364 bits (935), Expect = e-101
Identities = 185/335 (55%), Positives = 235/335 (70%), Gaps = 6/335 (1%)
Query: 68 PCIIIETPHKEIGTSDFSRFTNYRFKNLFINPS---PLPDLSWGCSKEVWLNMLKKESRY 124
PC +I TP KE D + N K I PS PLP LSW +EVW ML KE Y
Sbjct: 71 PCSLIPTPDKE---DDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTY 127
Query: 125 VHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNM 184
+ D+HF H L+P+MR+ILLDWL+EVCEVY LHRETFYLAQDFFDR+M TQ+++ K +
Sbjct: 128 LRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTL 187
Query: 185 LQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTII 244
LQLIGI+SLFIA+KLEEIY PKL +FAYVTDGACS ++IL MEL+I+KALKW L P+TI+
Sbjct: 188 LQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIV 247
Query: 245 SWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAALCHF 304
SWLN+++QV L D +VLLPQY Q+ FIQIA+LLDLC+L +D LEF Y IL A+AL HF
Sbjct: 248 SWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHF 307
Query: 305 TSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTHTNYL 364
+S E+++K SG +W I CV WMVPF V++ T KLK F+ + ED HNIQTH + L
Sbjct: 308 SSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSL 367
Query: 365 AMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEK 399
+L++ + G++TPP+S +K
Sbjct: 368 DLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKK 402
>gi|17318561 cyclin E1 isoform 2 [Homo sapiens]
Length = 395
Score = 364 bits (935), Expect = e-101
Identities = 185/335 (55%), Positives = 235/335 (70%), Gaps = 6/335 (1%)
Query: 68 PCIIIETPHKEIGTSDFSRFTNYRFKNLFINPS---PLPDLSWGCSKEVWLNMLKKESRY 124
PC +I TP KE D + N K I PS PLP LSW +EVW ML KE Y
Sbjct: 56 PCSLIPTPDKE---DDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTY 112
Query: 125 VHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNM 184
+ D+HF H L+P+MR+ILLDWL+EVCEVY LHRETFYLAQDFFDR+M TQ+++ K +
Sbjct: 113 LRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTL 172
Query: 185 LQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTII 244
LQLIGI+SLFIA+KLEEIY PKL +FAYVTDGACS ++IL MEL+I+KALKW L P+TI+
Sbjct: 173 LQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIV 232
Query: 245 SWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAALCHF 304
SWLN+++QV L D +VLLPQY Q+ FIQIA+LLDLC+L +D LEF Y IL A+AL HF
Sbjct: 233 SWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHF 292
Query: 305 TSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTHTNYL 364
+S E+++K SG +W I CV WMVPF V++ T KLK F+ + ED HNIQTH + L
Sbjct: 293 SSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSL 352
Query: 365 AMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEK 399
+L++ + G++TPP+S +K
Sbjct: 353 DLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKK 387
>gi|161377472 cyclin A1 isoform c [Homo sapiens]
Length = 421
Score = 103 bits (256), Expect = 4e-22
Identities = 54/143 (37%), Positives = 88/143 (61%), Gaps = 1/143 (0%)
Query: 110 SKEVWLNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDF 169
++E++ + + E R+ H+ D+ MR+IL+DWL+EV E Y L ET YLA +F
Sbjct: 168 AEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNF 227
Query: 170 FDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELI 229
DRF L+ + + LQL+G ++ +ASK EEIY P++ EF Y+TD ++ +L+ME +
Sbjct: 228 LDRF-LSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHL 286
Query: 230 ILKALKWELCPVTIISWLNLFLQ 252
+LK L ++L T +L +L+
Sbjct: 287 LLKVLAFDLTVPTTNQFLLQYLR 309
>gi|161377470 cyclin A1 isoform c [Homo sapiens]
Length = 421
Score = 103 bits (256), Expect = 4e-22
Identities = 54/143 (37%), Positives = 88/143 (61%), Gaps = 1/143 (0%)
Query: 110 SKEVWLNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDF 169
++E++ + + E R+ H+ D+ MR+IL+DWL+EV E Y L ET YLA +F
Sbjct: 168 AEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNF 227
Query: 170 FDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELI 229
DRF L+ + + LQL+G ++ +ASK EEIY P++ EF Y+TD ++ +L+ME +
Sbjct: 228 LDRF-LSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHL 286
Query: 230 ILKALKWELCPVTIISWLNLFLQ 252
+LK L ++L T +L +L+
Sbjct: 287 LLKVLAFDLTVPTTNQFLLQYLR 309
>gi|161377468 cyclin A1 isoform b [Homo sapiens]
Length = 464
Score = 103 bits (256), Expect = 4e-22
Identities = 54/143 (37%), Positives = 88/143 (61%), Gaps = 1/143 (0%)
Query: 110 SKEVWLNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDF 169
++E++ + + E R+ H+ D+ MR+IL+DWL+EV E Y L ET YLA +F
Sbjct: 211 AEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNF 270
Query: 170 FDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELI 229
DRF L+ + + LQL+G ++ +ASK EEIY P++ EF Y+TD ++ +L+ME +
Sbjct: 271 LDRF-LSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHL 329
Query: 230 ILKALKWELCPVTIISWLNLFLQ 252
+LK L ++L T +L +L+
Sbjct: 330 LLKVLAFDLTVPTTNQFLLQYLR 352
>gi|4502611 cyclin A1 isoform a [Homo sapiens]
Length = 465
Score = 103 bits (256), Expect = 4e-22
Identities = 54/143 (37%), Positives = 88/143 (61%), Gaps = 1/143 (0%)
Query: 110 SKEVWLNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDF 169
++E++ + + E R+ H+ D+ MR+IL+DWL+EV E Y L ET YLA +F
Sbjct: 212 AEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNF 271
Query: 170 FDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELI 229
DRF L+ + + LQL+G ++ +ASK EEIY P++ EF Y+TD ++ +L+ME +
Sbjct: 272 LDRF-LSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHL 330
Query: 230 ILKALKWELCPVTIISWLNLFLQ 252
+LK L ++L T +L +L+
Sbjct: 331 LLKVLAFDLTVPTTNQFLLQYLR 353
>gi|4502613 cyclin A [Homo sapiens]
Length = 432
Score = 100 bits (248), Expect = 3e-21
Identities = 48/115 (41%), Positives = 76/115 (66%), Gaps = 1/115 (0%)
Query: 136 DLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFI 195
D+ MR+IL+DWL+EV E Y L ET +LA ++ DRF L+ + + LQL+G ++ +
Sbjct: 205 DITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLL 263
Query: 196 ASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTIISWLNLF 250
ASK EEIY P++ EF Y+TD +++ +LRME ++LK L ++L T+ +L +
Sbjct: 264 ASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQY 318
>gi|4757930 cyclin B2 [Homo sapiens]
Length = 398
Score = 99.0 bits (245), Expect = 7e-21
Identities = 63/188 (33%), Positives = 101/188 (53%), Gaps = 21/188 (11%)
Query: 124 YVHDKHFEVLHS---------DLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFM 174
Y + + EVL S D+ +MR+IL+DWL++V + L +ET Y+ DRF+
Sbjct: 139 YQYLRQLEVLQSINPHFLDGRDINGRMRAILVDWLVQVHSKFRLLQETLYMCVGIMDRFL 198
Query: 175 LTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKAL 234
Q +++ LQL+GIT+L +ASK EE+++P +++F Y+TD A + I ME +ILK L
Sbjct: 199 QVQP-VSRKKLQLVGITALLLASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKEL 257
Query: 235 KWELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYR 294
K+E L L + L+ A K Q T + L++L ++ D + +
Sbjct: 258 KFE---------LGRPLPLHFLRRASKAGEVDVEQHTLAK--YLMELTLIDYDMVHYHPS 306
Query: 295 ILTAAALC 302
+ AAA C
Sbjct: 307 KVAAAASC 314
>gi|14327896 cyclin B1 [Homo sapiens]
Length = 433
Score = 96.7 bits (239), Expect = 3e-20
Identities = 63/183 (34%), Positives = 101/183 (55%), Gaps = 14/183 (7%)
Query: 120 KESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKD 179
+E + V K+ +L ++ MR+IL+DWL++V + L +ET Y+ DRFM
Sbjct: 182 EEEQAVRPKY--LLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFM-QNNC 238
Query: 180 INKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELC 239
+ K MLQL+G+T++FIASK EE+Y P++ +FA+VTD ++ I +ME+ IL+AL +
Sbjct: 239 VPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF--- 295
Query: 240 PVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAA 299
L L + L+ A K+ Q T + L++L +L D + F + A
Sbjct: 296 ------GLGRPLPLHFLRRASKIGEVDVEQHTLAK--YLMELTMLDYDMVHFPPSQIAAG 347
Query: 300 ALC 302
A C
Sbjct: 348 AFC 350
>gi|16950655 cyclin D1 [Homo sapiens]
Length = 295
Score = 93.2 bits (230), Expect = 4e-19
Identities = 52/160 (32%), Positives = 90/160 (56%), Gaps = 3/160 (1%)
Query: 117 MLKKESRYVHD-KHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFML 175
MLK E +F+ + ++ P MR I+ W+LEVCE E F LA ++ DRF L
Sbjct: 31 MLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRF-L 89
Query: 176 TQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALK 235
+ + + K+ LQL+G T +F+ASK++E ++ TD + E++L+MEL+++ LK
Sbjct: 90 SLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLK 149
Query: 236 WELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQI 275
W L +T ++ FL + K ++ +++Q TF+ +
Sbjct: 150 WNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQ-TFVAL 188
>gi|4502617 cyclin D2 [Homo sapiens]
Length = 289
Score = 88.6 bits (218), Expect = 9e-18
Identities = 53/161 (32%), Positives = 86/161 (53%), Gaps = 3/161 (1%)
Query: 116 NMLKKESRYVHD-KHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFM 174
N+L E RY+ +F+ + D++P MR ++ W+LEVCE E F LA ++ DRF
Sbjct: 29 NLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRF- 87
Query: 175 LTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKAL 234
L K+ LQL+G +F+ASKL+E ++ TD + +++L EL++L L
Sbjct: 88 LAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKL 147
Query: 235 KWELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQI 275
KW L VT ++ L+ + K+ L + +TFI +
Sbjct: 148 KWNLAAVTPHDFIEHILR-KLPQQREKLSLIRKHAQTFIAL 187
>gi|4502619 cyclin D3 isoform 2 [Homo sapiens]
Length = 292
Score = 86.3 bits (212), Expect = 5e-17
Identities = 64/233 (27%), Positives = 111/233 (47%), Gaps = 9/233 (3%)
Query: 99 PSPLPDLSWGCSKEVWLNMLKKESRYV-HDKHFEVLHSDLEPQMRSILLDWLLEVCEVYT 157
P PD + V ++L+ E RYV +F+ + +++P MR +L W+LEVCE
Sbjct: 13 PRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQR 72
Query: 158 LHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGA 217
E F LA ++ DR+ L+ K LQL+G + +ASKL E +++ TD A
Sbjct: 73 CEEEVFPLAMNYLDRY-LSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHA 131
Query: 218 CSEEDILRMELIILKALKWELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIA- 276
S + E+++L LKW+L V +L L +L + L+ +++Q TF+ +
Sbjct: 132 VSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQ-TFLALCA 190
Query: 277 -----QLLDLCILAIDSLEFQYRILTAAALCHFTSIEVVKKASGLEWDSISEC 324
+ ++A S+ + L A ++ E++ +G E D + C
Sbjct: 191 TDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRAC 243
>gi|90669307 cyclin B3 isoform 3 [Homo sapiens]
Length = 1395
Score = 77.4 bits (189), Expect = 2e-14
Identities = 41/129 (31%), Positives = 75/129 (58%), Gaps = 2/129 (1%)
Query: 110 SKEVWLNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDF 169
+KE++ M ++E +++ + ++ MR+IL+DWL+EV + + ET YLA
Sbjct: 1130 AKEIFSYMKEREEQFILTDYMN-RQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKL 1188
Query: 170 FDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELI 229
D +++ + K+ LQL+G T+ IA+K EE +P++ +F Y+ D ++L ME+
Sbjct: 1189 VDLYLM-KAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEIN 1247
Query: 230 ILKALKWEL 238
IL LK ++
Sbjct: 1248 ILNVLKCDI 1256
>gi|5802992 cyclin I [Homo sapiens]
Length = 377
Score = 73.9 bits (180), Expect = 2e-13
Identities = 63/224 (28%), Positives = 112/224 (50%), Gaps = 20/224 (8%)
Query: 134 HSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSL 193
+ ++ P R ++ WL ++ + L+ ETF LA DRF+ T K + L I I+
Sbjct: 37 NQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVK-AHPKYLSCIAISCF 95
Query: 194 FIASKL--EEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTIISWLNLFL 251
F+A+K E+ P L+ A + CS +ILRME IIL L W+L T + +L++F
Sbjct: 96 FLAAKTVEEDERIPVLKVLARDSFCGCSSSEILRMERIILDKLNWDLHTATPLDFLHIFH 155
Query: 252 QVDALKDAPKVL--LPQY--SQETFIQIAQLLDLCILAIDSLEFQYRILTAAALC----- 302
+ A+ P++L LP+ SQ + QLL C+ L+F+ +L A +
Sbjct: 156 AI-AVSTRPQLLFSLPKLSPSQHLAVLTKQLLH-CMACNQLLQFRGSMLALAMVSLEMEK 213
Query: 303 -----HFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPV 341
+IE+++KA ++ + C + + ++ ++S+ P+
Sbjct: 214 LIPDWLSLTIELLQKAQ-MDSSQLIHCRELVAHHLSTLQSSLPL 256
>gi|153791755 cyclin domain containing [Homo sapiens]
Length = 350
Score = 62.0 bits (149), Expect = 9e-10
Identities = 39/132 (29%), Positives = 65/132 (49%), Gaps = 1/132 (0%)
Query: 119 KKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQK 178
K + + H + + + R LL WL+ V + L E+ L + DRF LT
Sbjct: 110 KAQESHFHPREALARQPQVTAESRCKLLSWLIPVHRQFGLSFESLCLTVNTLDRF-LTTT 168
Query: 179 DINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWEL 238
+ + QL+G+TSL IA K E++ P++++ + GA S + + +E I+L L + L
Sbjct: 169 PVAADCFQLLGVTSLLIACKQVEVHPPRVKQLLALCCGAFSRQQLCNLECIVLHKLHFTL 228
Query: 239 CPVTIISWLNLF 250
TI +L F
Sbjct: 229 GAPTISFFLEHF 240
>gi|242247025 cyclin N-terminal domain containing 2 isoform 2 [Homo
sapiens]
Length = 307
Score = 61.2 bits (147), Expect = 2e-09
Identities = 33/100 (33%), Positives = 57/100 (57%), Gaps = 1/100 (1%)
Query: 139 PQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASK 198
P+MR++++DWL++V E L +T YLA D ++ + + + LQL+G+ LF+A K
Sbjct: 105 PEMRALVVDWLVQVHEYLGLAGDTLYLAVHLLDSYLSAGR-VRLHRLQLLGVACLFVACK 163
Query: 199 LEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWEL 238
+EE P+ ++ + S ++LR E IL L + L
Sbjct: 164 MEECVLPEPAFLCLLSADSFSRAELLRAERRILSRLDFRL 203
>gi|89886237 cyclin I family, member 2 [Homo sapiens]
Length = 369
Score = 58.5 bits (140), Expect = 1e-08
Identities = 46/150 (30%), Positives = 76/150 (50%), Gaps = 7/150 (4%)
Query: 148 WLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKL--EEIYAP 205
WLL + + + TF LA F R +++ K + + L ITSL +A+K+ EE + P
Sbjct: 156 WLLRLQNTFYFSQSTFNLALTIFGRLLISVK-VKEKYLHCATITSLRLAAKVNEEEEFIP 214
Query: 206 KLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTIISWLNLFLQVDALKDAPKV--L 263
++++F S ++LRMEL IL L W+L T + +L +F + L P V L
Sbjct: 215 QVKDFTKHYGSDYSPNELLRMELAILDRLHWDLYIGTPLDFLTIFHALVVL-SWPHVLEL 273
Query: 264 LPQYSQETFI-QIAQLLDLCILAIDSLEFQ 292
LPQ + + + + L C+ L+F+
Sbjct: 274 LPQRNPSLHVASLTRQLQHCMAGHQLLQFK 303
>gi|16306525 cyclin B3 isoform 1 [Homo sapiens]
Length = 291
Score = 55.8 bits (133), Expect = 7e-08
Identities = 28/83 (33%), Positives = 48/83 (57%), Gaps = 1/83 (1%)
Query: 156 YTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTD 215
+ + ET YLA D +++ + K+ LQL+G T+ IA+K EE +P++ +F Y+ D
Sbjct: 71 FEMTHETLYLAVKLVDLYLM-KAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICD 129
Query: 216 GACSEEDILRMELIILKALKWEL 238
++L ME+ IL LK ++
Sbjct: 130 DNYQRSEVLSMEINILNVLKCDI 152
>gi|4757936 cyclin G2 [Homo sapiens]
Length = 344
Score = 53.5 bits (127), Expect = 3e-07
Identities = 33/114 (28%), Positives = 59/114 (51%), Gaps = 3/114 (2%)
Query: 139 PQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASK 198
P +R+ ++ L + + ETF LA + DRF+ K + L IG+ S +A++
Sbjct: 53 PGLRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMK-VKPKHLSCIGVCSFLLAAR 111
Query: 199 L--EEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTIISWLNLF 250
+ E+ P + ++ C+ DI RME II + L +EL T +++L+L+
Sbjct: 112 IVEEDCNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALNFLHLY 165
>gi|118572588 cyclin F [Homo sapiens]
Length = 786
Score = 52.0 bits (123), Expect = 1e-06
Identities = 35/134 (26%), Positives = 67/134 (50%), Gaps = 1/134 (0%)
Query: 118 LKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQ 177
L + S+ V + + L MR IL+DWL+EV + +L + DR+ L +
Sbjct: 286 LFQASQAVSKQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRY-LRR 344
Query: 178 KDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWE 237
+ + + LQL+GI + I ++ ++E ++TD ED++RM I+ AL+ +
Sbjct: 345 RLVPRYRLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGK 404
Query: 238 LCPVTIISWLNLFL 251
+ T++ + + L
Sbjct: 405 IRVPTVVDYKEVLL 418
>gi|197276674 cyclin J isoform 1 [Homo sapiens]
Length = 383
Score = 49.3 bits (116), Expect = 6e-06
Identities = 49/210 (23%), Positives = 93/210 (44%), Gaps = 29/210 (13%)
Query: 141 MRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKLE 200
+R D + V +TL +LA D FM + DI+ L L+ ++ L +ASK E
Sbjct: 39 LRRYFADLIAIVSNRFTLCPSARHLAVYLLDLFM-DRYDISIQQLHLVALSCLLLASKFE 97
Query: 201 EIY--APKLQEFAYV-----TDGACSEEDILRMELIILKALKWELCPVTIISWLNLFL-- 251
E PKL++ + + +++++L MEL++L+ +W LC T ++ +L
Sbjct: 98 EKEDSVPKLEQLNSLGCMTNMNLVLTKQNLLHMELLLLETFQWNLCLPTAAHFIEYYLSE 157
Query: 252 ---QVDALKDAPKVLLPQYSQETFIQIAQLLD--LCILAIDSLEFQYRILTAAALCHFTS 306
+ D P + L ++T + +A+ D L + D Y AA C +S
Sbjct: 158 AVHETDLHDGWPMICL----EKTKLYMAKYADYFLEVSLQDYAFLNYAPSLVAAACVASS 213
Query: 307 IEVVK----------KASGLEWDSISECVD 326
+++ + + WD + +C++
Sbjct: 214 RIILRLSPTWPTRLHRLTAYSWDFLVQCIE 243
>gi|209862835 cyclin D3 isoform 1 [Homo sapiens]
Length = 211
Score = 48.1 bits (113), Expect = 1e-05
Identities = 40/163 (24%), Positives = 75/163 (46%), Gaps = 8/163 (4%)
Query: 168 DFFDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRME 227
++ DR+ L+ K LQL+G + +ASKL E +++ TD A S + E
Sbjct: 2 NYLDRY-LSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWE 60
Query: 228 LIILKALKWELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIA------QLLDL 281
+++L LKW+L V +L L +L + L+ +++Q TF+ + +
Sbjct: 61 VLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQ-TFLALCATDYTFAMYPP 119
Query: 282 CILAIDSLEFQYRILTAAALCHFTSIEVVKKASGLEWDSISEC 324
++A S+ + L A ++ E++ +G E D + C
Sbjct: 120 SMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRAC 162
>gi|40254889 cyclin J isoform 2 [Homo sapiens]
Length = 372
Score = 47.4 bits (111), Expect = 2e-05
Identities = 48/208 (23%), Positives = 91/208 (43%), Gaps = 36/208 (17%)
Query: 141 MRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKLE 200
+R D + V +TL +LA D FM + DI+ L L+ ++ L +ASK E
Sbjct: 39 LRRYFADLIAIVSNRFTLCPSARHLAVYLLDLFM-DRYDISIQQLHLVALSCLLLASKFE 97
Query: 201 EIY--APKLQEFAYV-----TDGACSEEDILRMELIILKALKWELCPVTIISWLNLFL-- 251
E PKL++ + + +++++L MEL++L+ +W LC T ++ +L
Sbjct: 98 EKEDSVPKLEQLNSLGCMTNMNLVLTKQNLLHMELLLLETFQWNLCLPTAAHFIEYYLSE 157
Query: 252 ---QVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAALCHFTSIE 308
+ D P + L ++T + +A+ D F L AA C +S
Sbjct: 158 AVHETDLHDGWPMICL----EKTKLYMAKYADY---------FLEVSLQVAAACVASSRI 204
Query: 309 VVK----------KASGLEWDSISECVD 326
+++ + + WD + +C++
Sbjct: 205 ILRLSPTWPTRLHRLTAYSWDFLVQCIE 232
>gi|40805832 cyclin G1 [Homo sapiens]
Length = 295
Score = 46.6 bits (109), Expect = 4e-05
Identities = 29/113 (25%), Positives = 56/113 (49%), Gaps = 3/113 (2%)
Query: 140 QMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKL 199
++R + LL + + + ETF LA + DRF+ K + L +G++ ++A K
Sbjct: 50 RLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMK-VQPKHLGCVGLSCFYLAVKS 108
Query: 200 --EEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTIISWLNLF 250
EE P + ++ + D++RME I+L+ + W++ T +L L+
Sbjct: 109 IEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLY 161
>gi|4757934 cyclin G1 [Homo sapiens]
Length = 295
Score = 46.6 bits (109), Expect = 4e-05
Identities = 29/113 (25%), Positives = 56/113 (49%), Gaps = 3/113 (2%)
Query: 140 QMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKL 199
++R + LL + + + ETF LA + DRF+ K + L +G++ ++A K
Sbjct: 50 RLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMK-VQPKHLGCVGLSCFYLAVKS 108
Query: 200 --EEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTIISWLNLF 250
EE P + ++ + D++RME I+L+ + W++ T +L L+
Sbjct: 109 IEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLY 161
>gi|197276676 cyclin J isoform 3 [Homo sapiens]
Length = 371
Score = 46.6 bits (109), Expect = 4e-05
Identities = 33/118 (27%), Positives = 59/118 (50%), Gaps = 8/118 (6%)
Query: 141 MRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKLE 200
+R D + V +TL +LA D FM + DI+ L L+ ++ L +ASK E
Sbjct: 39 LRRYFADLIAIVSNRFTLCPSARHLAVYLLDLFM-DRYDISIQQLHLVALSCLLLASKFE 97
Query: 201 EIY--APKLQEFAYV-----TDGACSEEDILRMELIILKALKWELCPVTIISWLNLFL 251
E PKL++ + + +++++L MEL++L+ +W LC T ++ +L
Sbjct: 98 EKEDSVPKLEQLNSLGCMTNMNLVLTKQNLLHMELLLLETFQWNLCLPTAAHFIEYYL 155
>gi|94680985 cyclin J-like [Homo sapiens]
Length = 435
Score = 35.8 bits (81), Expect = 0.071
Identities = 37/169 (21%), Positives = 74/169 (43%), Gaps = 20/169 (11%)
Query: 198 KLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTIISWLNLFL-----Q 252
KLE+I + ++ T +++++L EL++L+A W LC T +L+ +L Q
Sbjct: 153 KLEQINSTRILSSQNFT---LTKKELLSTELLLLEAFSWNLCLPTPAHFLDYYLLASVSQ 209
Query: 253 VDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAALCHFTS------ 306
D P+ ++E + A L + D + ++++ AA C S
Sbjct: 210 KDHHCHTWPTTCPRKTKECLKEYAHYF-LEVTLQDHIFYKFQPSVVAAACVGASRICLQL 268
Query: 307 ----IEVVKKASGLEWDSISECVD-WMVPFVNVVKSTSPVKLKTFKKIP 350
+++ S + +S C++ +V + NV+K VK + +P
Sbjct: 269 SPYWTRDLQRISSYSLEHLSTCIEILLVVYDNVLKDAVAVKSQALAMVP 317
>gi|209915553 cyclin D3 isoform 3 [Homo sapiens]
Length = 220
Score = 35.0 bits (79), Expect = 0.12
Identities = 22/69 (31%), Positives = 36/69 (52%), Gaps = 1/69 (1%)
Query: 99 PSPLPDLSWGCSKEVWLNMLKKESRYV-HDKHFEVLHSDLEPQMRSILLDWLLEVCEVYT 157
P PD + V ++L+ E RYV +F+ + +++P MR +L W+LE EV
Sbjct: 13 PRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEDWEVLV 72
Query: 158 LHRETFYLA 166
L + + LA
Sbjct: 73 LGKLKWDLA 81
>gi|187173292 troponin T1, skeletal, slow isoform c [Homo sapiens]
Length = 251
Score = 32.7 bits (73), Expect = 0.60
Identities = 18/47 (38%), Positives = 29/47 (61%), Gaps = 2/47 (4%)
Query: 3 RRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKK 49
RRS R A+QQ ++ E ++A++ + K RK ++ KKR E+ KK
Sbjct: 95 RRSER--AEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKK 139
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,892,732
Number of Sequences: 37866
Number of extensions: 691502
Number of successful extensions: 2357
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2301
Number of HSP's gapped (non-prelim): 42
length of query: 404
length of database: 18,247,518
effective HSP length: 105
effective length of query: 299
effective length of database: 14,271,588
effective search space: 4267204812
effective search space used: 4267204812
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.