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Search of human proteins with 170932512
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|170932512 FERM domain containing 1 isoform 2 [Homo sapiens]
(481 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|170932512 FERM domain containing 1 isoform 2 [Homo sapiens] 991 0.0
gi|170932510 FERM domain containing 1 isoform 1 [Homo sapiens] 984 0.0
gi|109715866 FERM domain containing 6 [Homo sapiens] 370 e-102
gi|22748721 FERM domain containing 6 [Homo sapiens] 370 e-102
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 126 5e-29
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 125 1e-28
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 125 1e-28
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 125 1e-28
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 94 2e-19
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 94 2e-19
gi|161702986 ezrin [Homo sapiens] 74 3e-13
gi|21614499 ezrin [Homo sapiens] 74 3e-13
gi|4506467 radixin [Homo sapiens] 74 4e-13
gi|4505257 moesin [Homo sapiens] 72 1e-12
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 64 4e-10
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 64 4e-10
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 64 4e-10
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 64 4e-10
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 62 9e-10
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 62 2e-09
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 62 2e-09
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 60 4e-09
gi|117500790 FERM domain containing 3 [Homo sapiens] 60 6e-09
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 57 3e-08
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 56 8e-08
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 56 8e-08
gi|38788243 myosin regulatory light chain interacting protein [H... 54 3e-07
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 54 3e-07
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 53 5e-07
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 53 7e-07
>gi|170932512 FERM domain containing 1 isoform 2 [Homo sapiens]
Length = 481
Score = 991 bits (2561), Expect = 0.0
Identities = 481/481 (100%), Positives = 481/481 (100%)
Query: 1 MDDVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNE 60
MDDVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNE
Sbjct: 1 MDDVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNE 60
Query: 61 GNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAAC 120
GNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAAC
Sbjct: 61 GNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAAC 120
Query: 121 ALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLC 180
ALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLC
Sbjct: 121 ALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLC 180
Query: 181 FIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLV 240
FIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLV
Sbjct: 181 FIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLV 240
Query: 241 YYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDLAS 300
YYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDLAS
Sbjct: 241 YYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDLAS 300
Query: 301 RSFPGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLEVHGLHEKE 360
RSFPGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLEVHGLHEKE
Sbjct: 301 RSFPGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLEVHGLHEKE 360
Query: 361 PSSSPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDD 420
PSSSPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDD
Sbjct: 361 PSSSPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDD 420
Query: 421 MQLHQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFGEAPPQEFV 480
MQLHQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFGEAPPQEFV
Sbjct: 421 MQLHQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFGEAPPQEFV 480
Query: 481 V 481
V
Sbjct: 481 V 481
>gi|170932510 FERM domain containing 1 isoform 1 [Homo sapiens]
Length = 549
Score = 984 bits (2544), Expect = 0.0
Identities = 478/478 (100%), Positives = 478/478 (100%)
Query: 4 VKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNE 63
VKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNE
Sbjct: 72 VKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNE 131
Query: 64 KPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQ 123
KPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQ
Sbjct: 132 KPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQ 191
Query: 124 ADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQ 183
ADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQ
Sbjct: 192 ADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQ 251
Query: 184 EACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVYYT 243
EACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVYYT
Sbjct: 252 EACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVYYT 311
Query: 244 GCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDLASRSF 303
GCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDLASRSF
Sbjct: 312 GCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDLASRSF 371
Query: 304 PGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLEVHGLHEKEPSS 363
PGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLEVHGLHEKEPSS
Sbjct: 372 PGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLEVHGLHEKEPSS 431
Query: 364 SPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQL 423
SPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQL
Sbjct: 432 SPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQL 491
Query: 424 HQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFGEAPPQEFVV 481
HQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFGEAPPQEFVV
Sbjct: 492 HQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFGEAPPQEFVV 549
>gi|109715866 FERM domain containing 6 [Homo sapiens]
Length = 614
Score = 370 bits (949), Expect = e-102
Identities = 229/585 (39%), Positives = 324/585 (55%), Gaps = 109/585 (18%)
Query: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
+VK +L QVC++ ++D FGL V++NNE+++M+L QKL KY K+WKKE ++G
Sbjct: 33 NVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKKEASKGI 92
Query: 63 EKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 122
++ P + RVQ+YVENGR+ISD AR+ YY HL+++VL SQC REEAYFLLAA AL
Sbjct: 93 DQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVLREEAYFLLAAFAL 152
Query: 123 QADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFI 182
QADLG + + H G+YFEP +YFP W+++KRG DYIL+H+P +H+++ L+ EA L +I
Sbjct: 153 QADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPNMHKDQFALTASEAHLKYI 212
Query: 183 QEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ-------------------- 222
+EA RL+DV VH++RL+KDK+E ++ LGL +RG+ I+Q
Sbjct: 213 KEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKL 272
Query: 223 ---GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEA 279
GKK EI DGLP+A+KL+YYTGC RSRHLL LL SH+L++ ++P L+ +R+ EE
Sbjct: 273 VFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNLQPVLRHIRKLEEN 332
Query: 280 EEKQHYRESYISDELELDL-----ASRSFPGSGVSSQHCPHCLSRHSADSHGSSYTSGIK 334
EEK+ YRESYISD L+LD+ SR+ S S +H LSRHS SH SS+TSGI+
Sbjct: 333 EEKKQYRESYISDNLDLDMDQLEKRSRASGSSAGSMKH--KRLSRHSTASHSSSHTSGIE 390
Query: 335 ANSWLRESR------------------------------------------------EMS 346
A++ R++ EM
Sbjct: 391 ADTKPRDTGPEDSYSSSAIHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDLQDDEIEML 450
Query: 347 VDVPLEVHGLHEKEPSSSP-------------RTSRSHPS--TRGDSQATRQEPCTQVRT 391
VD P ++ ++E+ SP R H + +T T V+
Sbjct: 451 VDDPRDLEQMNEESLEVSPDMCIYITEDMLMSRKLNGHSGLIVKEIGSSTSSSSETVVKL 510
Query: 392 RGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQLHQ-----LALHPAPTSLSHTF------- 439
RGQS +++ Q S ++HS LDD++L+Q +A T+ S+TF
Sbjct: 511 RGQSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELD 570
Query: 440 HRALDCR--LAGPC-ETRATLPSKRSSNCLALDLFGEAPPQEFVV 481
L C LA C + P KR+S +LDL + P EFVV
Sbjct: 571 EEGLYCNSCLAQQCINIQDAFPVKRTSKYFSLDLTHDEVP-EFVV 614
>gi|22748721 FERM domain containing 6 [Homo sapiens]
Length = 614
Score = 370 bits (949), Expect = e-102
Identities = 229/585 (39%), Positives = 324/585 (55%), Gaps = 109/585 (18%)
Query: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
+VK +L QVC++ ++D FGL V++NNE+++M+L QKL KY K+WKKE ++G
Sbjct: 33 NVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKKEASKGI 92
Query: 63 EKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 122
++ P + RVQ+YVENGR+ISD AR+ YY HL+++VL SQC REEAYFLLAA AL
Sbjct: 93 DQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVLREEAYFLLAAFAL 152
Query: 123 QADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFI 182
QADLG + + H G+YFEP +YFP W+++KRG DYIL+H+P +H+++ L+ EA L +I
Sbjct: 153 QADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPNMHKDQFALTASEAHLKYI 212
Query: 183 QEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ-------------------- 222
+EA RL+DV VH++RL+KDK+E ++ LGL +RG+ I+Q
Sbjct: 213 KEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKL 272
Query: 223 ---GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEA 279
GKK EI DGLP+A+KL+YYTGC RSRHLL LL SH+L++ ++P L+ +R+ EE
Sbjct: 273 VFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNLQPVLRHIRKLEEN 332
Query: 280 EEKQHYRESYISDELELDL-----ASRSFPGSGVSSQHCPHCLSRHSADSHGSSYTSGIK 334
EEK+ YRESYISD L+LD+ SR+ S S +H LSRHS SH SS+TSGI+
Sbjct: 333 EEKKQYRESYISDNLDLDMDQLEKRSRASGSSAGSMKH--KRLSRHSTASHSSSHTSGIE 390
Query: 335 ANSWLRESR------------------------------------------------EMS 346
A++ R++ EM
Sbjct: 391 ADTKPRDTGPEDSYSSSAIHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDLQDDEIEML 450
Query: 347 VDVPLEVHGLHEKEPSSSP-------------RTSRSHPS--TRGDSQATRQEPCTQVRT 391
VD P ++ ++E+ SP R H + +T T V+
Sbjct: 451 VDDPRDLEQMNEESLEVSPDMCIYITEDMLMSRKLNGHSGLIVKEIGSSTSSSSETVVKL 510
Query: 392 RGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQLHQ-----LALHPAPTSLSHTF------- 439
RGQS +++ Q S ++HS LDD++L+Q +A T+ S+TF
Sbjct: 511 RGQSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELD 570
Query: 440 HRALDCR--LAGPC-ETRATLPSKRSSNCLALDLFGEAPPQEFVV 481
L C LA C + P KR+S +LDL + P EFVV
Sbjct: 571 EEGLYCNSCLAQQCINIQDAFPVKRTSKYFSLDLTHDEVP-EFVV 614
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 126 bits (316), Expect = 5e-29
Identities = 87/320 (27%), Positives = 149/320 (46%), Gaps = 26/320 (8%)
Query: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
D K +++F V + + F L +++NEY F+D + KL+K + WK+E +
Sbjct: 589 DTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKK-K 647
Query: 63 EKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 122
K F F R++ ++++ +I H YY L++ +L + +E LLA+ AL
Sbjct: 648 TKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLAL 707
Query: 123 QADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFI 182
QA+ G+++ H YF Y P ++ K + YI +P LH G S KE L F+
Sbjct: 708 QAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFL 767
Query: 183 QEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ-------------------- 222
+ RL + VHF R+H +KK + ++LG+ +GV +++
Sbjct: 768 KVCQRLTEYGVHFHRVHPEKK-SQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKI 826
Query: 223 -GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEE 281
K +I L K + T + ++LLHL H+ L++R +Q Q + +
Sbjct: 827 SFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMR--ARQSNQDAQDID 884
Query: 282 KQHYRESYISD-ELELDLAS 300
H R S +S E E+ L +
Sbjct: 885 VLHKRWSIVSSPEREITLVN 904
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 125 bits (313), Expect = 1e-28
Identities = 83/300 (27%), Positives = 139/300 (46%), Gaps = 25/300 (8%)
Query: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
D K +++F V + + F L +++NEY F+D + KL+K + WK+E +
Sbjct: 589 DTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKK-K 647
Query: 63 EKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 122
K F F R++ ++++ +I H YY L++ +L + +E LLA+ AL
Sbjct: 648 TKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLAL 707
Query: 123 QADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFI 182
QA+ G+++ H YF Y P ++ K + YI +P LH G S KE L F+
Sbjct: 708 QAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFL 767
Query: 183 QEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ-------------------- 222
+ RL + VHF R+H +KK + ++LG+ +GV +++
Sbjct: 768 KVCQRLTEYGVHFHRVHPEKK-SQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKI 826
Query: 223 -GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASH--QLHLRVRPTLQQLRQREEA 279
K +I L K + T + ++LLHL H QL +R R + Q + E A
Sbjct: 827 SFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERA 886
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 125 bits (313), Expect = 1e-28
Identities = 83/300 (27%), Positives = 139/300 (46%), Gaps = 25/300 (8%)
Query: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
D K +++F V + + F L +++NEY F+D + KL+K + WK+E +
Sbjct: 589 DTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKK-K 647
Query: 63 EKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 122
K F F R++ ++++ +I H YY L++ +L + +E LLA+ AL
Sbjct: 648 TKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLAL 707
Query: 123 QADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFI 182
QA+ G+++ H YF Y P ++ K + YI +P LH G S KE L F+
Sbjct: 708 QAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFL 767
Query: 183 QEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ-------------------- 222
+ RL + VHF R+H +KK + ++LG+ +GV +++
Sbjct: 768 KVCQRLTEYGVHFHRVHPEKK-SQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKI 826
Query: 223 -GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASH--QLHLRVRPTLQQLRQREEA 279
K +I L K + T + ++LLHL H QL +R R + Q + E A
Sbjct: 827 SFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERA 886
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13
isoform 2 [Homo sapiens]
Length = 2466
Score = 125 bits (313), Expect = 1e-28
Identities = 83/300 (27%), Positives = 139/300 (46%), Gaps = 25/300 (8%)
Query: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
D K +++F V + + F L +++NEY F+D + KL+K + WK+E +
Sbjct: 589 DTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKK-K 647
Query: 63 EKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 122
K F F R++ ++++ +I H YY L++ +L + +E LLA+ AL
Sbjct: 648 TKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLAL 707
Query: 123 QADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFI 182
QA+ G+++ H YF Y P ++ K + YI +P LH G S KE L F+
Sbjct: 708 QAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFL 767
Query: 183 QEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ-------------------- 222
+ RL + VHF R+H +KK + ++LG+ +GV +++
Sbjct: 768 KVCQRLTEYGVHFHRVHPEKK-SQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKI 826
Query: 223 -GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASH--QLHLRVRPTLQQLRQREEA 279
K +I L K + T + ++LLHL H QL +R R + Q + E A
Sbjct: 827 SFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERA 886
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 94.4 bits (233), Expect = 2e-19
Identities = 56/223 (25%), Positives = 108/223 (48%), Gaps = 4/223 (1%)
Query: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
DV++T +F V + A++ + +FGL +++ E+ F+D E +L K + W R +
Sbjct: 337 DVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGW---REQPQ 393
Query: 63 EKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 122
+ F FLR++ +V + ++ RH +Y L++ +L + EE L AL
Sbjct: 394 KTSMNTFTLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLAL 453
Query: 123 QADLGEH-RESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCF 181
QA+ G + +E + YF Y P +I + + + +HR L ++A L F
Sbjct: 454 QAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKF 513
Query: 182 IQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGK 224
++ +L + V ++ +K+ + LG+ +GV +Y+ K
Sbjct: 514 LRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVK 556
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 94.4 bits (233), Expect = 2e-19
Identities = 56/223 (25%), Positives = 108/223 (48%), Gaps = 4/223 (1%)
Query: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
DV++T +F V + A++ + +FGL +++ E+ F+D E +L K + W R +
Sbjct: 359 DVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGW---REQPQ 415
Query: 63 EKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 122
+ F FLR++ +V + ++ RH +Y L++ +L + EE L AL
Sbjct: 416 KTSMNTFTLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLAL 475
Query: 123 QADLGEH-RESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCF 181
QA+ G + +E + YF Y P +I + + + +HR L ++A L F
Sbjct: 476 QAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKF 535
Query: 182 IQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGK 224
++ +L + V ++ +K+ + LG+ +GV +Y+ K
Sbjct: 536 LRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVK 578
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 73.9 bits (180), Expect = 3e-13
Identities = 70/308 (22%), Positives = 136/308 (44%), Gaps = 42/308 (13%)
Query: 7 TGRELFQQVCNVASIRDAQFFGLCVVRNNEY-IFMDLEQKLSKYFSKDWKKERNEGNEKP 65
TG++LF QV +R+ +FGL V N + ++ L++K+S +++ +KE
Sbjct: 25 TGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS---AQEVRKEN------- 74
Query: 66 RAPFVAFLRVQHYVEN-GRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQA 124
P R + Y E+ + + L++ +KE +L + E LL + A+QA
Sbjct: 75 --PLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQA 132
Query: 125 DLGEHRESAHAGRYFEPHSYFPQWIITKRGI--DYILRHMPTLHRERQGLSPKEAMLCFI 182
G++ + H Y PQ ++ + + D + H E +G+ AML ++
Sbjct: 133 KFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYL 192
Query: 183 QEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLP-------- 234
+ A LE +++F + K+KK + LG+ G++IY+ G P
Sbjct: 193 KIAQDLEMYGINYFEI-KNKK--GTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNIS 249
Query: 235 -------------AAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVR--PTLQQLRQREEA 279
A V+Y ++ +L L +H+L++R R T++ + + +A
Sbjct: 250 FNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQA 309
Query: 280 EEKQHYRE 287
E++H ++
Sbjct: 310 REEKHQKQ 317
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 73.9 bits (180), Expect = 3e-13
Identities = 70/308 (22%), Positives = 136/308 (44%), Gaps = 42/308 (13%)
Query: 7 TGRELFQQVCNVASIRDAQFFGLCVVRNNEY-IFMDLEQKLSKYFSKDWKKERNEGNEKP 65
TG++LF QV +R+ +FGL V N + ++ L++K+S +++ +KE
Sbjct: 25 TGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS---AQEVRKEN------- 74
Query: 66 RAPFVAFLRVQHYVEN-GRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQA 124
P R + Y E+ + + L++ +KE +L + E LL + A+QA
Sbjct: 75 --PLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQA 132
Query: 125 DLGEHRESAHAGRYFEPHSYFPQWIITKRGI--DYILRHMPTLHRERQGLSPKEAMLCFI 182
G++ + H Y PQ ++ + + D + H E +G+ AML ++
Sbjct: 133 KFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYL 192
Query: 183 QEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLP-------- 234
+ A LE +++F + K+KK + LG+ G++IY+ G P
Sbjct: 193 KIAQDLEMYGINYFEI-KNKK--GTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNIS 249
Query: 235 -------------AAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVR--PTLQQLRQREEA 279
A V+Y ++ +L L +H+L++R R T++ + + +A
Sbjct: 250 FNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQA 309
Query: 280 EEKQHYRE 287
E++H ++
Sbjct: 310 REEKHQKQ 317
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 73.6 bits (179), Expect = 4e-13
Identities = 70/308 (22%), Positives = 138/308 (44%), Gaps = 42/308 (13%)
Query: 7 TGRELFQQVCNVASIRDAQFFGLCVVRNNEY-IFMDLEQKLSKYFSKDWKKERNEGNEKP 65
TG++LF QV +R+ FFGL V + Y ++ L +K+++ +D KKE
Sbjct: 25 TGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQ---QDVKKEN------- 74
Query: 66 RAPFVAFLRVQHYVEN-GRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQA 124
P R + + E+ + + L++ +KE +L + E LLA+ A+QA
Sbjct: 75 --PLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQA 132
Query: 125 DLGEHRESAHAGRYFEPHSYFPQWIITKRGI--DYILRHMPTLHRERQGLSPKEAMLCFI 182
G++ + H Y PQ ++ + + + + H E +G+ +++M+ ++
Sbjct: 133 KYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYL 192
Query: 183 QEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLP-------- 234
+ A LE V++F + K+KK + LG+ G++IY+ G P
Sbjct: 193 KIAQDLEMYGVNYFEI-KNKK--GTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNIS 249
Query: 235 -------------AAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVR--PTLQQLRQREEA 279
A V+Y ++ +L L +H+L++R R T++ + + +A
Sbjct: 250 FNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQA 309
Query: 280 EEKQHYRE 287
E++H ++
Sbjct: 310 REEKHQKQ 317
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 71.6 bits (174), Expect = 1e-12
Identities = 72/309 (23%), Positives = 138/309 (44%), Gaps = 44/309 (14%)
Query: 7 TGRELFQQVCNVASIRDAQFFGLCVVRNNEY-IFMDLEQKLSKYFSKDWKKERNEGNEKP 65
TG++LF QV +R+ FFGL + ++ L +K++ ++D +KE
Sbjct: 25 TGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVT---AQDVRKE-------- 73
Query: 66 RAPFVAFLRVQHYVEN--GRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQ 123
+P + R + Y E+ +I D R L++ +KE +L E LLA+ A+Q
Sbjct: 74 -SPLLFKFRAKFYPEDVSEELIQDITQR-LFFLQVKEGILNDDIYCPPETAVLLASYAVQ 131
Query: 124 ADLGEHRESAHAGRYFEPHSYFPQWIITKRGI--DYILRHMPTLHRERQGLSPKEAMLCF 181
+ G+ + H Y PQ ++ + + D + H E +G+ ++A+L +
Sbjct: 132 SKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEY 191
Query: 182 IQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLP------- 234
++ A LE V++F + K+KK + LG+ G++IY+ G P
Sbjct: 192 LKIAQDLEMYGVNYFSI-KNKKGSE--LWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNI 248
Query: 235 --------------AAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVR--PTLQQLRQREE 278
A V+Y ++ +L L +H+L++R R T++ + + +
Sbjct: 249 SFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQ 308
Query: 279 AEEKQHYRE 287
A E++H ++
Sbjct: 309 AREEKHQKQ 317
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 63.5 bits (153), Expect = 4e-10
Identities = 52/222 (23%), Positives = 100/222 (45%), Gaps = 18/222 (8%)
Query: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
++K G++LF VC +R+ FFGL + ++ +++K+ + D KE
Sbjct: 38 EMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDH---DVSKEE---- 90
Query: 63 EKPRAPFVAFLRVQHYVENGRV-ISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACA 121
P + Y EN + +HL++ +K+++L + EA LLA+ A
Sbjct: 91 -----PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYA 145
Query: 122 LQADLGEHRESAHAGRYFEPHSYFPQWIIT--KRGIDYILRHMPTLHRERQGLSPKEAML 179
+QA G++ S H + P+ +I + + + + E +G + EA +
Sbjct: 146 VQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEM 205
Query: 180 CFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIY 221
+++ A LE V++F + K ++LG+ G+HIY
Sbjct: 206 EYLKIAQDLEMYGVNYFAIRNKK---GTELLLGVDALGLHIY 244
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 63.5 bits (153), Expect = 4e-10
Identities = 52/222 (23%), Positives = 100/222 (45%), Gaps = 18/222 (8%)
Query: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
++K G++LF VC +R+ FFGL + ++ +++K+ + D KE
Sbjct: 38 EMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDH---DVSKEE---- 90
Query: 63 EKPRAPFVAFLRVQHYVENGRV-ISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACA 121
P + Y EN + +HL++ +K+++L + EA LLA+ A
Sbjct: 91 -----PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYA 145
Query: 122 LQADLGEHRESAHAGRYFEPHSYFPQWIIT--KRGIDYILRHMPTLHRERQGLSPKEAML 179
+QA G++ S H + P+ +I + + + + E +G + EA +
Sbjct: 146 VQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEM 205
Query: 180 CFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIY 221
+++ A LE V++F + K ++LG+ G+HIY
Sbjct: 206 EYLKIAQDLEMYGVNYFAIRNKK---GTELLLGVDALGLHIY 244
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 63.5 bits (153), Expect = 4e-10
Identities = 52/222 (23%), Positives = 100/222 (45%), Gaps = 18/222 (8%)
Query: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
++K G++LF VC +R+ FFGL + ++ +++K+ + D KE
Sbjct: 38 EMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDH---DVSKEE---- 90
Query: 63 EKPRAPFVAFLRVQHYVENGRV-ISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACA 121
P + Y EN + +HL++ +K+++L + EA LLA+ A
Sbjct: 91 -----PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYA 145
Query: 122 LQADLGEHRESAHAGRYFEPHSYFPQWIIT--KRGIDYILRHMPTLHRERQGLSPKEAML 179
+QA G++ S H + P+ +I + + + + E +G + EA +
Sbjct: 146 VQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEM 205
Query: 180 CFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIY 221
+++ A LE V++F + K ++LG+ G+HIY
Sbjct: 206 EYLKIAQDLEMYGVNYFAIRNKK---GTELLLGVDALGLHIY 244
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 63.5 bits (153), Expect = 4e-10
Identities = 52/222 (23%), Positives = 100/222 (45%), Gaps = 18/222 (8%)
Query: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
++K G++LF VC +R+ FFGL + ++ +++K+ + D KE
Sbjct: 38 EMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDH---DVSKEE---- 90
Query: 63 EKPRAPFVAFLRVQHYVENGRV-ISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACA 121
P + Y EN + +HL++ +K+++L + EA LLA+ A
Sbjct: 91 -----PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYA 145
Query: 122 LQADLGEHRESAHAGRYFEPHSYFPQWIIT--KRGIDYILRHMPTLHRERQGLSPKEAML 179
+QA G++ S H + P+ +I + + + + E +G + EA +
Sbjct: 146 VQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEM 205
Query: 180 CFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIY 221
+++ A LE V++F + K ++LG+ G+HIY
Sbjct: 206 EYLKIAQDLEMYGVNYFAIRNKK---GTELLLGVDALGLHIY 244
>gi|34328899 protein tyrosine phosphatase, non-receptor type 14
[Homo sapiens]
Length = 1187
Score = 62.4 bits (150), Expect = 9e-10
Identities = 52/219 (23%), Positives = 96/219 (43%), Gaps = 18/219 (8%)
Query: 4 VKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYI-FMDLEQKLSKYFSKDWKKERNEGN 62
V++TG+E + V +R+ +FGL + ++ +++LE+ L K+ K N
Sbjct: 39 VESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKKHLDKF-------AN 91
Query: 63 EKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 122
E + F V YV N + R+ YY +K+ VL + + LA A+
Sbjct: 92 EP-----LLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLAGLAV 146
Query: 123 QADLGEHRESAHAGRYFEPHSYFPQWIITKRGI-DYILRHMPTLHRERQGLSPKEAMLCF 181
QAD G++ + + + + FP + + + + + + + H+ G+ P EA L +
Sbjct: 147 QADFGDYNQ-FDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPAEAELMY 205
Query: 182 IQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHI 220
I E RL+ F + K V LG+ G+ +
Sbjct: 206 INEVERLDGFGQEIFPV---KDNHGNCVHLGIFFMGIFV 241
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 61.6 bits (148), Expect = 2e-09
Identities = 51/216 (23%), Positives = 95/216 (43%), Gaps = 20/216 (9%)
Query: 7 TGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKPR 66
TG+ L V N + + ++FGL ++ +D + L SK +K+ G
Sbjct: 50 TGQVLLDMVHNHLGVTEKEYFGL----QHDDDSVDSPRWLEA--SKAIRKQLKGG----- 98
Query: 67 APFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQADL 126
P RV+ ++ + + + RHLY+ LK + + + +LA+ A+Q+
Sbjct: 99 FPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHF 158
Query: 127 GEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQEAC 186
G++ S H Y + P + D++ + + +LH + GL EA C+I A
Sbjct: 159 GDYNSSIHHPGYLSDSHFIPD-----QNEDFLTK-VESLHEQHSGLKQSEAESCYINIAR 212
Query: 187 RLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ 222
L+ V LH + +++G+A GV +Y+
Sbjct: 213 TLDFYGV---ELHSGRDLHNLDLMIGIASAGVAVYR 245
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 61.6 bits (148), Expect = 2e-09
Identities = 51/216 (23%), Positives = 95/216 (43%), Gaps = 20/216 (9%)
Query: 7 TGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKPR 66
TG+ L V N + + ++FGL ++ +D + L SK +K+ G
Sbjct: 50 TGQVLLDMVHNHLGVTEKEYFGL----QHDDDSVDSPRWLEA--SKAIRKQLKGG----- 98
Query: 67 APFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQADL 126
P RV+ ++ + + + RHLY+ LK + + + +LA+ A+Q+
Sbjct: 99 FPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHF 158
Query: 127 GEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQEAC 186
G++ S H Y + P + D++ + + +LH + GL EA C+I A
Sbjct: 159 GDYNSSIHHPGYLSDSHFIPD-----QNEDFLTK-VESLHEQHSGLKQSEAESCYINIAR 212
Query: 187 RLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ 222
L+ V LH + +++G+A GV +Y+
Sbjct: 213 TLDFYGV---ELHSGRDLHNLDLMIGIASAGVAVYR 245
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 60.1 bits (144), Expect = 4e-09
Identities = 39/161 (24%), Positives = 79/161 (49%), Gaps = 9/161 (5%)
Query: 64 KPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQ 123
K +P+ RV+ +V + + + R+ Y+ +K+ +L + LLA+ A+Q
Sbjct: 96 KRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQ 155
Query: 124 ADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQ 183
++LG++ +S + Y +S+ P + D+ + + LH++ GLSP EA ++
Sbjct: 156 SELGDYDQSENLSGYLSDYSFIP-----NQPQDF-EKEIAKLHQQHIGLSPAEAEFNYLN 209
Query: 184 EACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGK 224
A LE V F H + + +++G+ G+ IY+ +
Sbjct: 210 TARTLELYGVEF---HYARDQSNNEIMIGVMSGGILIYKNR 247
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 59.7 bits (143), Expect = 6e-09
Identities = 59/239 (24%), Positives = 98/239 (41%), Gaps = 31/239 (12%)
Query: 8 GRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNE--GNEKP 65
G+ L +CN S+ + +FG+ ++D E++ + W + K
Sbjct: 54 GQFLIDHICNYYSLLEKDYFGIR--------YVDPEKQ------RHWLEPNKSIFKQMKT 99
Query: 66 RAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQ--CAHREEAYFLLAACALQ 123
P+ RV+ Y I + R+L Y +K + + C+ + AY L AC +Q
Sbjct: 100 HPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAY--LGACIVQ 157
Query: 124 ADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHR-ERQGLSPKEAMLCFI 182
A+LG++ H P +Y ++ I + + R + +H+ E +G SP A +
Sbjct: 158 AELGDYDPDEH------PENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLL 211
Query: 183 QEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVY 241
+A LE V H K T LG G ++QG K I L P KL +
Sbjct: 212 LKAHTLETYGVD---PHPCKDSTGTTTFLGFTAAGFVVFQGNK-RIHLIKWPDVCKLKF 266
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 57.4 bits (137), Expect = 3e-08
Identities = 46/188 (24%), Positives = 87/188 (46%), Gaps = 15/188 (7%)
Query: 4 VKATGRELFQQVCNVASIRDAQFFGLCVV-RNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
V++TG+E + V +R+ +F L + N+ ++DLE+ L K K
Sbjct: 41 VESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLKKQLDK---------- 90
Query: 63 EKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 122
P V F V YV + + R+ YY LK+ +L E LA A+
Sbjct: 91 -YALEPTVYF-GVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAGLAV 148
Query: 123 QADLGEHRESAHAGRYFEPHSYFP-QWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCF 181
QAD G+ + + + + + FP W+ ++ ++ + + LH++ +GL+ +A + +
Sbjct: 149 QADFGDF-DQYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDAEMLY 207
Query: 182 IQEACRLE 189
+QE R++
Sbjct: 208 MQEVERMD 215
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 55.8 bits (133), Expect = 8e-08
Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 25/235 (10%)
Query: 8 GRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKPRA 67
G+ LF VC ++ + +FGL F D + + K+W E ++ R+
Sbjct: 57 GQVLFDLVCEHLNLLEKDYFGLT--------FCDADSQ------KNWLDPSKEIKKQIRS 102
Query: 68 -PFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQADL 126
P+ V+ Y + +++ R+ L+ ++ + + LL + A+QA+L
Sbjct: 103 SPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAEL 162
Query: 127 GEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQEAC 186
G++ H G Y + P T+ + I+ LH+ +G++P EA + F++ A
Sbjct: 163 GDYDAEEHVGNYVSELRFAPNQ--TRELEERIME----LHKTYRGMTPGEAEIHFLENAK 216
Query: 187 RLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVY 241
+L ++ LH K ++LG+ G+ IY+ +L I P K+ Y
Sbjct: 217 KLS---MYGVDLHHAKDSEGIDIMLGVCANGLLIYR-DRLRINRFAWPKILKISY 267
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 55.8 bits (133), Expect = 8e-08
Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 25/235 (10%)
Query: 8 GRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKPRA 67
G+ LF VC ++ + +FGL F D + + K+W E ++ R+
Sbjct: 119 GQVLFDLVCEHLNLLEKDYFGLT--------FCDADSQ------KNWLDPSKEIKKQIRS 164
Query: 68 -PFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQADL 126
P+ V+ Y + +++ R+ L+ ++ + + LL + A+QA+L
Sbjct: 165 SPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAEL 224
Query: 127 GEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQEAC 186
G++ H G Y + P T+ + I+ LH+ +G++P EA + F++ A
Sbjct: 225 GDYDAEEHVGNYVSELRFAPNQ--TRELEERIME----LHKTYRGMTPGEAEIHFLENAK 278
Query: 187 RLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVY 241
+L ++ LH K ++LG+ G+ IY+ +L I P K+ Y
Sbjct: 279 KLS---MYGVDLHHAKDSEGIDIMLGVCANGLLIYR-DRLRINRFAWPKILKISY 329
>gi|38788243 myosin regulatory light chain interacting protein [Homo
sapiens]
Length = 445
Score = 53.9 bits (128), Expect = 3e-07
Identities = 49/236 (20%), Positives = 94/236 (39%), Gaps = 26/236 (11%)
Query: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNN-EYIFMDLEQKLSKYFSKDWKKERNEG 61
+ KA G + QVC I + +FGL + E ++++L ++S+
Sbjct: 18 EAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDG--------- 68
Query: 62 NEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACA 121
AP+ LRV+ +VE ++ + + RH+++ H+KE +L E L+A
Sbjct: 69 ----LAPYRLKLRVKFFVEPHLILQE-QTRHIFFLHIKEALLAGHLLCSPEQAVELSALL 123
Query: 122 LQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCF 181
Q G++ ++ Y E + K L + H+E +G S A
Sbjct: 124 AQTKFGDYNQNTAKYNYEE--------LCAKELSSATLNSIVAKHKELEGTSQASAEYQV 175
Query: 182 IQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQ 237
+Q +E+ + + H + +++G+ G+ I + I P Q
Sbjct: 176 LQIVSAMENYGIEW---HSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQ 228
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 53.9 bits (128), Expect = 3e-07
Identities = 48/219 (21%), Positives = 98/219 (44%), Gaps = 20/219 (9%)
Query: 8 GRELFQQVCNVASIRDAQFFGLCVV-RNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKPR 66
G + V + ++ + +FGL R+++ ++D + L+++ K+ N G
Sbjct: 38 GSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAEH-----KELINTG----- 87
Query: 67 APFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQADL 126
P+ + ++ Y E+ + + R+ ++ +K+ VL+ + L A A+Q++L
Sbjct: 88 PPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAIQSEL 147
Query: 127 GEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQEAC 186
G++ H Y + + P K ++ + +H+ G P EA L +++ A
Sbjct: 148 GDYDPYKHTAGYVSEYRFVPD---QKEELEEAIER---IHKTLMGQIPSEAELNYLRTAK 201
Query: 187 RLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKK 225
LE ++ LH E + LGL GV +Y+ KK
Sbjct: 202 SLE---MYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKK 237
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 53.1 bits (126), Expect = 5e-07
Identities = 52/238 (21%), Positives = 102/238 (42%), Gaps = 25/238 (10%)
Query: 5 KATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNEK 64
++ G+ LF +VC ++ + +FGL + D E + K+W E ++
Sbjct: 129 RSRGQVLFDKVCEHLNLLEKDYFGLT--------YRDAENQ------KNWLDPAKEIKKQ 174
Query: 65 PRAPFVAF-LRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQ 123
R+ F V+ Y + +S+ R+ L++ ++ + LL + +Q
Sbjct: 175 VRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQ 234
Query: 124 ADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQ 183
++LG++ Y + P TK D ++ LH+ +G++P EA + F++
Sbjct: 235 SELGDYDPDECGSDYISEFRFAPNH--TKELEDKVIE----LHKSHRGMTPAEAEMHFLE 288
Query: 184 EACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVY 241
A +L ++ LH K ++LG+ G+ IY+ +L I P K+ Y
Sbjct: 289 NAKKLS---MYGVDLHHAKDSEGVEIMLGVCASGLLIYR-DRLRINRFAWPKVLKISY 342
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 52.8 bits (125), Expect = 7e-07
Identities = 52/237 (21%), Positives = 100/237 (42%), Gaps = 25/237 (10%)
Query: 6 ATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKP 65
A G++L ++VC ++ + +FGL + N SK W E ++
Sbjct: 21 AKGQDLLKRVCEHLNLLEEDYFGLAIWDNAT--------------SKTWLDSAKEIKKQV 66
Query: 66 R-APFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQA 124
R P+ V+ Y + +++ R+ L++ ++ + LL + +Q+
Sbjct: 67 RGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
Query: 125 DLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQE 184
+LG++ H Y P TK + ++ LH+ + ++P +A L F++
Sbjct: 127 ELGDYDPELHGVDYVSDFKLAPNQ--TKELEEKVME----LHKSYRSMTPAQADLEFLEN 180
Query: 185 ACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVY 241
A +L ++ LHK K +ILG+ G+ +Y+ KL I P K+ Y
Sbjct: 181 AKKLS---MYGVDLHKAKDLEGVDIILGVCSSGLLVYK-DKLRINRFPWPKVLKISY 233
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.134 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,849,183
Number of Sequences: 37866
Number of extensions: 938285
Number of successful extensions: 3070
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 2948
Number of HSP's gapped (non-prelim): 113
length of query: 481
length of database: 18,247,518
effective HSP length: 106
effective length of query: 375
effective length of database: 14,233,722
effective search space: 5337645750
effective search space used: 5337645750
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.