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Search of human proteins with 170932510
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|170932510 FERM domain containing 1 isoform 1 [Homo sapiens]
(549 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|170932510 FERM domain containing 1 isoform 1 [Homo sapiens] 1129 0.0
gi|170932512 FERM domain containing 1 isoform 2 [Homo sapiens] 984 0.0
gi|109715866 FERM domain containing 6 [Homo sapiens] 383 e-106
gi|22748721 FERM domain containing 6 [Homo sapiens] 383 e-106
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 131 2e-30
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 130 4e-30
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 130 4e-30
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 130 4e-30
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 100 6e-21
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 100 6e-21
gi|161702986 ezrin [Homo sapiens] 77 3e-14
gi|21614499 ezrin [Homo sapiens] 77 3e-14
gi|4506467 radixin [Homo sapiens] 77 4e-14
gi|4505257 moesin [Homo sapiens] 75 2e-13
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 63 6e-10
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 63 8e-10
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 63 8e-10
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 63 8e-10
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 63 8e-10
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 62 2e-09
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 62 2e-09
gi|117500790 FERM domain containing 3 [Homo sapiens] 61 3e-09
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 60 5e-09
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 60 5e-09
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 59 9e-09
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 57 6e-08
gi|38788243 myosin regulatory light chain interacting protein [H... 56 1e-07
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 55 1e-07
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 54 4e-07
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 53 8e-07
>gi|170932510 FERM domain containing 1 isoform 1 [Homo sapiens]
Length = 549
Score = 1129 bits (2920), Expect = 0.0
Identities = 549/549 (100%), Positives = 549/549 (100%)
Query: 1 MAVPPRGRGIDPARTNPDTFPPSGARCMEPSPERPACSQQEPTLGMDAMASEHRDVLVLL 60
MAVPPRGRGIDPARTNPDTFPPSGARCMEPSPERPACSQQEPTLGMDAMASEHRDVLVLL
Sbjct: 1 MAVPPRGRGIDPARTNPDTFPPSGARCMEPSPERPACSQQEPTLGMDAMASEHRDVLVLL 60
Query: 61 PSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSK 120
PSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSK
Sbjct: 61 PSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSK 120
Query: 121 DWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREE 180
DWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREE
Sbjct: 121 DWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREE 180
Query: 181 AYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGL 240
AYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGL
Sbjct: 181 AYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGL 240
Query: 241 SPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDG 300
SPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDG
Sbjct: 241 SPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDG 300
Query: 301 LPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISD 360
LPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISD
Sbjct: 301 LPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISD 360
Query: 361 ELELDLASRSFPGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLE 420
ELELDLASRSFPGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLE
Sbjct: 361 ELELDLASRSFPGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLE 420
Query: 421 VHGLHEKEPSSSPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEE 480
VHGLHEKEPSSSPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEE
Sbjct: 421 VHGLHEKEPSSSPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEE 480
Query: 481 QHSHGLDDMQLHQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFG 540
QHSHGLDDMQLHQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFG
Sbjct: 481 QHSHGLDDMQLHQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFG 540
Query: 541 EAPPQEFVV 549
EAPPQEFVV
Sbjct: 541 EAPPQEFVV 549
>gi|170932512 FERM domain containing 1 isoform 2 [Homo sapiens]
Length = 481
Score = 984 bits (2544), Expect = 0.0
Identities = 478/478 (100%), Positives = 478/478 (100%)
Query: 72 VKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNE 131
VKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNE
Sbjct: 4 VKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNE 63
Query: 132 KPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQ 191
KPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQ
Sbjct: 64 KPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQ 123
Query: 192 ADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQ 251
ADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQ
Sbjct: 124 ADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQ 183
Query: 252 EACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVYYT 311
EACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVYYT
Sbjct: 184 EACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVYYT 243
Query: 312 GCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDLASRSF 371
GCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDLASRSF
Sbjct: 244 GCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDLASRSF 303
Query: 372 PGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLEVHGLHEKEPSS 431
PGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLEVHGLHEKEPSS
Sbjct: 304 PGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLEVHGLHEKEPSS 363
Query: 432 SPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQL 491
SPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQL
Sbjct: 364 SPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQL 423
Query: 492 HQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFGEAPPQEFVV 549
HQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFGEAPPQEFVV
Sbjct: 424 HQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFGEAPPQEFVV 481
>gi|109715866 FERM domain containing 6 [Homo sapiens]
Length = 614
Score = 383 bits (984), Expect = e-106
Identities = 235/604 (38%), Positives = 334/604 (55%), Gaps = 109/604 (18%)
Query: 52 EHRDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLE 111
+ R V + LP+ E L + + VK +L QVC++ ++D FGL V++NNE+++M+L
Sbjct: 14 DRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELS 73
Query: 112 QKLSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVL 171
QKL KY K+WKKE ++G ++ P + RVQ+YVENGR+ISD AR+ YY HL+++VL
Sbjct: 74 QKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVL 133
Query: 172 RSQCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMP 231
SQC REEAYFLLAA ALQADLG + + H G+YFEP +YFP W+++KRG DYIL+H+P
Sbjct: 134 HSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIP 193
Query: 232 TLHRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ- 290
+H+++ L+ EA L +I+EA RL+DV VH++RL+KDK+E ++ LGL +RG+ I+Q
Sbjct: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
Query: 291 ----------------------GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASH 328
GKK EI DGLP+A+KL+YYTGC RSRHLL LL SH
Sbjct: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSH 313
Query: 329 QLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDL-----ASRSFPGSGVSSQHCPH 383
+L++ ++P L+ +R+ EE EEK+ YRESYISD L+LD+ SR+ S S +H
Sbjct: 314 RLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRASGSSAGSMKH--K 371
Query: 384 CLSRHSADSHGSSYTSGIKANSWLRESR-------------------------------- 411
LSRHS SH SS+TSGI+A++ R++
Sbjct: 372 RLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMTSHGSSHTSGVE 431
Query: 412 ----------------EMSVDVPLEVHGLHEKEPSSSP-------------RTSRSHPS- 441
EM VD P ++ ++E+ SP R H
Sbjct: 432 SGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDMLMSRKLNGHSGL 491
Query: 442 -TRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQLHQ-----LA 495
+ +T T V+ RGQS +++ Q S ++HS LDD++L+Q +A
Sbjct: 492 IVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIA 551
Query: 496 LHPAPTSLSHTF-------HRALDCR--LAGPC-ETRATLPSKRSSNCLALDLFGEAPPQ 545
T+ S+TF L C LA C + P KR+S +LDL + P
Sbjct: 552 GLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYFSLDLTHDEVP- 610
Query: 546 EFVV 549
EFVV
Sbjct: 611 EFVV 614
>gi|22748721 FERM domain containing 6 [Homo sapiens]
Length = 614
Score = 383 bits (984), Expect = e-106
Identities = 235/604 (38%), Positives = 334/604 (55%), Gaps = 109/604 (18%)
Query: 52 EHRDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLE 111
+ R V + LP+ E L + + VK +L QVC++ ++D FGL V++NNE+++M+L
Sbjct: 14 DRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELS 73
Query: 112 QKLSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVL 171
QKL KY K+WKKE ++G ++ P + RVQ+YVENGR+ISD AR+ YY HL+++VL
Sbjct: 74 QKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVL 133
Query: 172 RSQCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMP 231
SQC REEAYFLLAA ALQADLG + + H G+YFEP +YFP W+++KRG DYIL+H+P
Sbjct: 134 HSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIP 193
Query: 232 TLHRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ- 290
+H+++ L+ EA L +I+EA RL+DV VH++RL+KDK+E ++ LGL +RG+ I+Q
Sbjct: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
Query: 291 ----------------------GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASH 328
GKK EI DGLP+A+KL+YYTGC RSRHLL LL SH
Sbjct: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSH 313
Query: 329 QLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDL-----ASRSFPGSGVSSQHCPH 383
+L++ ++P L+ +R+ EE EEK+ YRESYISD L+LD+ SR+ S S +H
Sbjct: 314 RLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRASGSSAGSMKH--K 371
Query: 384 CLSRHSADSHGSSYTSGIKANSWLRESR-------------------------------- 411
LSRHS SH SS+TSGI+A++ R++
Sbjct: 372 RLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMTSHGSSHTSGVE 431
Query: 412 ----------------EMSVDVPLEVHGLHEKEPSSSP-------------RTSRSHPS- 441
EM VD P ++ ++E+ SP R H
Sbjct: 432 SGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDMLMSRKLNGHSGL 491
Query: 442 -TRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQLHQ-----LA 495
+ +T T V+ RGQS +++ Q S ++HS LDD++L+Q +A
Sbjct: 492 IVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIA 551
Query: 496 LHPAPTSLSHTF-------HRALDCR--LAGPC-ETRATLPSKRSSNCLALDLFGEAPPQ 545
T+ S+TF L C LA C + P KR+S +LDL + P
Sbjct: 552 GLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYFSLDLTHDEVP- 610
Query: 546 EFVV 549
EFVV
Sbjct: 611 EFVV 614
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 131 bits (329), Expect = 2e-30
Identities = 91/337 (27%), Positives = 158/337 (46%), Gaps = 26/337 (7%)
Query: 54 RDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQK 113
R V ++L + ++L L K +++F V + + F L +++NEY F+D + K
Sbjct: 572 RKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLK 631
Query: 114 LSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRS 173
L+K + WK+E + K F F R++ ++++ +I H YY L++ +L
Sbjct: 632 LTKVAPEGWKEEPKK-KTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEE 690
Query: 174 QCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTL 233
+ +E LLA+ ALQA+ G+++ H YF Y P ++ K + YI +P L
Sbjct: 691 RMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKL 750
Query: 234 HRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ--- 290
H G S KE L F++ RL + VHF R+H +KK + ++LG+ +GV +++
Sbjct: 751 HNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKK-SQTGILLGVCSKGVLVFEVHN 809
Query: 291 ------------------GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASHQLHL 332
K +I L K + T + ++LLHL H+ L
Sbjct: 810 GVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQL 869
Query: 333 RVRPTLQQLRQREEAEEKQHYRESYISD-ELELDLAS 368
++R +Q Q + + H R S +S E E+ L +
Sbjct: 870 QMR--ARQSNQDAQDIDVLHKRWSIVSSPEREITLVN 904
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 130 bits (326), Expect = 4e-30
Identities = 87/317 (27%), Positives = 148/317 (46%), Gaps = 25/317 (7%)
Query: 54 RDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQK 113
R V ++L + ++L L K +++F V + + F L +++NEY F+D + K
Sbjct: 572 RKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLK 631
Query: 114 LSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRS 173
L+K + WK+E + K F F R++ ++++ +I H YY L++ +L
Sbjct: 632 LTKVAPEGWKEEPKK-KTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEE 690
Query: 174 QCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTL 233
+ +E LLA+ ALQA+ G+++ H YF Y P ++ K + YI +P L
Sbjct: 691 RMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKL 750
Query: 234 HRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ--- 290
H G S KE L F++ RL + VHF R+H +KK + ++LG+ +GV +++
Sbjct: 751 HNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKK-SQTGILLGVCSKGVLVFEVHN 809
Query: 291 ------------------GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASH--QL 330
K +I L K + T + ++LLHL H QL
Sbjct: 810 GVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQL 869
Query: 331 HLRVRPTLQQLRQREEA 347
+R R + Q + E A
Sbjct: 870 QMRARQSNQDAQDIERA 886
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 130 bits (326), Expect = 4e-30
Identities = 87/317 (27%), Positives = 148/317 (46%), Gaps = 25/317 (7%)
Query: 54 RDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQK 113
R V ++L + ++L L K +++F V + + F L +++NEY F+D + K
Sbjct: 572 RKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLK 631
Query: 114 LSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRS 173
L+K + WK+E + K F F R++ ++++ +I H YY L++ +L
Sbjct: 632 LTKVAPEGWKEEPKK-KTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEE 690
Query: 174 QCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTL 233
+ +E LLA+ ALQA+ G+++ H YF Y P ++ K + YI +P L
Sbjct: 691 RMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKL 750
Query: 234 HRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ--- 290
H G S KE L F++ RL + VHF R+H +KK + ++LG+ +GV +++
Sbjct: 751 HNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKK-SQTGILLGVCSKGVLVFEVHN 809
Query: 291 ------------------GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASH--QL 330
K +I L K + T + ++LLHL H QL
Sbjct: 810 GVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQL 869
Query: 331 HLRVRPTLQQLRQREEA 347
+R R + Q + E A
Sbjct: 870 QMRARQSNQDAQDIERA 886
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13
isoform 2 [Homo sapiens]
Length = 2466
Score = 130 bits (326), Expect = 4e-30
Identities = 87/317 (27%), Positives = 148/317 (46%), Gaps = 25/317 (7%)
Query: 54 RDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQK 113
R V ++L + ++L L K +++F V + + F L +++NEY F+D + K
Sbjct: 572 RKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLK 631
Query: 114 LSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRS 173
L+K + WK+E + K F F R++ ++++ +I H YY L++ +L
Sbjct: 632 LTKVAPEGWKEEPKK-KTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEE 690
Query: 174 QCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTL 233
+ +E LLA+ ALQA+ G+++ H YF Y P ++ K + YI +P L
Sbjct: 691 RMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKL 750
Query: 234 HRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ--- 290
H G S KE L F++ RL + VHF R+H +KK + ++LG+ +GV +++
Sbjct: 751 HNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKK-SQTGILLGVCSKGVLVFEVHN 809
Query: 291 ------------------GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASH--QL 330
K +I L K + T + ++LLHL H QL
Sbjct: 810 GVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQL 869
Query: 331 HLRVRPTLQQLRQREEA 347
+R R + Q + E A
Sbjct: 870 QMRARQSNQDAQDIERA 886
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 99.8 bits (247), Expect = 6e-21
Identities = 60/240 (25%), Positives = 117/240 (48%), Gaps = 4/240 (1%)
Query: 54 RDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQK 113
RD+ V+L + + L + V++T +F V + A++ + +FGL +++ E+ F+D E +
Sbjct: 320 RDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETR 379
Query: 114 LSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRS 173
L K + W R + + F FLR++ +V + ++ RH +Y L++ +L
Sbjct: 380 LCKIAPEGW---REQPQKTSMNTFTLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEE 436
Query: 174 QCAHREEAYFLLAACALQADLGEH-RESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPT 232
+ EE L ALQA+ G + +E + YF Y P +I + + +
Sbjct: 437 RLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSE 496
Query: 233 LHRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGK 292
+HR L ++A L F++ +L + V ++ +K+ + LG+ +GV +Y+ K
Sbjct: 497 MHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVK 556
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 99.8 bits (247), Expect = 6e-21
Identities = 60/240 (25%), Positives = 117/240 (48%), Gaps = 4/240 (1%)
Query: 54 RDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQK 113
RD+ V+L + + L + V++T +F V + A++ + +FGL +++ E+ F+D E +
Sbjct: 342 RDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETR 401
Query: 114 LSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRS 173
L K + W R + + F FLR++ +V + ++ RH +Y L++ +L
Sbjct: 402 LCKIAPEGW---REQPQKTSMNTFTLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEE 458
Query: 174 QCAHREEAYFLLAACALQADLGEH-RESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPT 232
+ EE L ALQA+ G + +E + YF Y P +I + + +
Sbjct: 459 RLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSE 518
Query: 233 LHRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGK 292
+HR L ++A L F++ +L + V ++ +K+ + LG+ +GV +Y+ K
Sbjct: 519 MHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVK 578
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 77.4 bits (189), Expect = 3e-14
Identities = 72/318 (22%), Positives = 140/318 (44%), Gaps = 42/318 (13%)
Query: 65 QLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEY-IFMDLEQKLSKYFSKDWK 123
+L A+ TG++LF QV +R+ +FGL V N + ++ L++K+S +++ +
Sbjct: 15 ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS---AQEVR 71
Query: 124 KERNEGNEKPRAPFVAFLRVQHYVEN-GRVISDHRARHLYYCHLKERVLRSQCAHREEAY 182
KE P R + Y E+ + + L++ +KE +L + E
Sbjct: 72 KEN---------PLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETA 122
Query: 183 FLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGI--DYILRHMPTLHRERQGL 240
LL + A+QA G++ + H Y PQ ++ + + D + H E +G+
Sbjct: 123 VLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGM 182
Query: 241 SPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDG 300
AML +++ A LE +++F + K+KK + LG+ G++IY+ G
Sbjct: 183 LKDNAMLEYLKIAQDLEMYGINYFEI-KNKK--GTDLWLGVDALGLNIYEKDDKLTPKIG 239
Query: 301 LP---------------------AAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVR--PT 337
P A V+Y ++ +L L +H+L++R R T
Sbjct: 240 FPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDT 299
Query: 338 LQQLRQREEAEEKQHYRE 355
++ + + +A E++H ++
Sbjct: 300 IEVQQMKAQAREEKHQKQ 317
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 77.4 bits (189), Expect = 3e-14
Identities = 72/318 (22%), Positives = 140/318 (44%), Gaps = 42/318 (13%)
Query: 65 QLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEY-IFMDLEQKLSKYFSKDWK 123
+L A+ TG++LF QV +R+ +FGL V N + ++ L++K+S +++ +
Sbjct: 15 ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS---AQEVR 71
Query: 124 KERNEGNEKPRAPFVAFLRVQHYVEN-GRVISDHRARHLYYCHLKERVLRSQCAHREEAY 182
KE P R + Y E+ + + L++ +KE +L + E
Sbjct: 72 KEN---------PLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETA 122
Query: 183 FLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGI--DYILRHMPTLHRERQGL 240
LL + A+QA G++ + H Y PQ ++ + + D + H E +G+
Sbjct: 123 VLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGM 182
Query: 241 SPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDG 300
AML +++ A LE +++F + K+KK + LG+ G++IY+ G
Sbjct: 183 LKDNAMLEYLKIAQDLEMYGINYFEI-KNKK--GTDLWLGVDALGLNIYEKDDKLTPKIG 239
Query: 301 LP---------------------AAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVR--PT 337
P A V+Y ++ +L L +H+L++R R T
Sbjct: 240 FPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDT 299
Query: 338 LQQLRQREEAEEKQHYRE 355
++ + + +A E++H ++
Sbjct: 300 IEVQQMKAQAREEKHQKQ 317
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 77.0 bits (188), Expect = 4e-14
Identities = 72/318 (22%), Positives = 142/318 (44%), Gaps = 42/318 (13%)
Query: 65 QLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEY-IFMDLEQKLSKYFSKDWK 123
+L A+ TG++LF QV +R+ FFGL V + Y ++ L +K+++ +D K
Sbjct: 15 ELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQ---QDVK 71
Query: 124 KERNEGNEKPRAPFVAFLRVQHYVEN-GRVISDHRARHLYYCHLKERVLRSQCAHREEAY 182
KE P R + + E+ + + L++ +KE +L + E
Sbjct: 72 KEN---------PLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETA 122
Query: 183 FLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGI--DYILRHMPTLHRERQGL 240
LLA+ A+QA G++ + H Y PQ ++ + + + + H E +G+
Sbjct: 123 VLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGM 182
Query: 241 SPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDG 300
+++M+ +++ A LE V++F + K+KK + LG+ G++IY+ G
Sbjct: 183 LREDSMMEYLKIAQDLEMYGVNYFEI-KNKK--GTELWLGVDALGLNIYEHDDKLTPKIG 239
Query: 301 LP---------------------AAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVR--PT 337
P A V+Y ++ +L L +H+L++R R T
Sbjct: 240 FPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDT 299
Query: 338 LQQLRQREEAEEKQHYRE 355
++ + + +A E++H ++
Sbjct: 300 IEVQQMKAQAREEKHQKQ 317
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 75.1 bits (183), Expect = 2e-13
Identities = 74/319 (23%), Positives = 142/319 (44%), Gaps = 44/319 (13%)
Query: 65 QLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEY-IFMDLEQKLSKYFSKDWK 123
+L A+ TG++LF QV +R+ FFGL + ++ L +K++ ++D +
Sbjct: 15 ELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVT---AQDVR 71
Query: 124 KERNEGNEKPRAPFVAFLRVQHYVE--NGRVISDHRARHLYYCHLKERVLRSQCAHREEA 181
KE +P + R + Y E + +I D R L++ +KE +L E
Sbjct: 72 KE---------SPLLFKFRAKFYPEDVSEELIQDITQR-LFFLQVKEGILNDDIYCPPET 121
Query: 182 YFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGI--DYILRHMPTLHRERQG 239
LLA+ A+Q+ G+ + H Y PQ ++ + + D + H E +G
Sbjct: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
Query: 240 LSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLD 299
+ ++A+L +++ A LE V++F + K+KK + LG+ G++IY+
Sbjct: 182 MLREDAVLEYLKIAQDLEMYGVNYFSI-KNKKGSE--LWLGVDALGLNIYEQNDRLTPKI 238
Query: 300 GLP---------------------AAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVR--P 336
G P A V+Y ++ +L L +H+L++R R
Sbjct: 239 GFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPD 298
Query: 337 TLQQLRQREEAEEKQHYRE 355
T++ + + +A E++H ++
Sbjct: 299 TIEVQQMKAQAREEKHQKQ 317
>gi|34328899 protein tyrosine phosphatase, non-receptor type 14
[Homo sapiens]
Length = 1187
Score = 63.2 bits (152), Expect = 6e-10
Identities = 52/225 (23%), Positives = 98/225 (43%), Gaps = 18/225 (8%)
Query: 66 LRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYI-FMDLEQKLSKYFSKDWKK 124
+ + V++TG+E + V +R+ +FGL + ++ +++LE+ L K+ K
Sbjct: 33 IECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKKHLDKF--- 89
Query: 125 ERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFL 184
NE + F V YV N + R+ YY +K+ VL + +
Sbjct: 90 ----ANEP-----LLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIR 140
Query: 185 LAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGI-DYILRHMPTLHRERQGLSPK 243
LA A+QAD G++ + + + + FP + + + + + + + H+ G+ P
Sbjct: 141 LAGLAVQADFGDYNQ-FDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPA 199
Query: 244 EAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHI 288
EA L +I E RL+ F + K V LG+ G+ +
Sbjct: 200 EAELMYINEVERLDGFGQEIFPV---KDNHGNCVHLGIFFMGIFV 241
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 62.8 bits (151), Expect = 8e-10
Identities = 52/221 (23%), Positives = 99/221 (44%), Gaps = 18/221 (8%)
Query: 72 VKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNE 131
+K G++LF VC +R+ FFGL + ++ +++K+ + D KE
Sbjct: 39 MKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDH---DVSKEE----- 90
Query: 132 KPRAPFVAFLRVQHYVENGRV-ISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 190
P + Y EN + +HL++ +K+++L + EA LLA+ A+
Sbjct: 91 ----PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAV 146
Query: 191 QADLGEHRESAHAGRYFEPHSYFPQWIIT--KRGIDYILRHMPTLHRERQGLSPKEAMLC 248
QA G++ S H + P+ +I + + + + E +G + EA +
Sbjct: 147 QAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEME 206
Query: 249 FIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIY 289
+++ A LE V++F + K ++LG+ G+HIY
Sbjct: 207 YLKIAQDLEMYGVNYFAIRNKK---GTELLLGVDALGLHIY 244
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 62.8 bits (151), Expect = 8e-10
Identities = 52/221 (23%), Positives = 99/221 (44%), Gaps = 18/221 (8%)
Query: 72 VKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNE 131
+K G++LF VC +R+ FFGL + ++ +++K+ + D KE
Sbjct: 39 MKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDH---DVSKEE----- 90
Query: 132 KPRAPFVAFLRVQHYVENGRV-ISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 190
P + Y EN + +HL++ +K+++L + EA LLA+ A+
Sbjct: 91 ----PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAV 146
Query: 191 QADLGEHRESAHAGRYFEPHSYFPQWIIT--KRGIDYILRHMPTLHRERQGLSPKEAMLC 248
QA G++ S H + P+ +I + + + + E +G + EA +
Sbjct: 147 QAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEME 206
Query: 249 FIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIY 289
+++ A LE V++F + K ++LG+ G+HIY
Sbjct: 207 YLKIAQDLEMYGVNYFAIRNKK---GTELLLGVDALGLHIY 244
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 62.8 bits (151), Expect = 8e-10
Identities = 52/221 (23%), Positives = 99/221 (44%), Gaps = 18/221 (8%)
Query: 72 VKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNE 131
+K G++LF VC +R+ FFGL + ++ +++K+ + D KE
Sbjct: 39 MKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDH---DVSKEE----- 90
Query: 132 KPRAPFVAFLRVQHYVENGRV-ISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 190
P + Y EN + +HL++ +K+++L + EA LLA+ A+
Sbjct: 91 ----PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAV 146
Query: 191 QADLGEHRESAHAGRYFEPHSYFPQWIIT--KRGIDYILRHMPTLHRERQGLSPKEAMLC 248
QA G++ S H + P+ +I + + + + E +G + EA +
Sbjct: 147 QAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEME 206
Query: 249 FIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIY 289
+++ A LE V++F + K ++LG+ G+HIY
Sbjct: 207 YLKIAQDLEMYGVNYFAIRNKK---GTELLLGVDALGLHIY 244
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 62.8 bits (151), Expect = 8e-10
Identities = 52/221 (23%), Positives = 99/221 (44%), Gaps = 18/221 (8%)
Query: 72 VKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNE 131
+K G++LF VC +R+ FFGL + ++ +++K+ + D KE
Sbjct: 39 MKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDH---DVSKEE----- 90
Query: 132 KPRAPFVAFLRVQHYVENGRV-ISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 190
P + Y EN + +HL++ +K+++L + EA LLA+ A+
Sbjct: 91 ----PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAV 146
Query: 191 QADLGEHRESAHAGRYFEPHSYFPQWIIT--KRGIDYILRHMPTLHRERQGLSPKEAMLC 248
QA G++ S H + P+ +I + + + + E +G + EA +
Sbjct: 147 QAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEME 206
Query: 249 FIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIY 289
+++ A LE V++F + K ++LG+ G+HIY
Sbjct: 207 YLKIAQDLEMYGVNYFAIRNKK---GTELLLGVDALGLHIY 244
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 61.6 bits (148), Expect = 2e-09
Identities = 51/216 (23%), Positives = 95/216 (43%), Gaps = 20/216 (9%)
Query: 75 TGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKPR 134
TG+ L V N + + ++FGL ++ +D + L SK +K+ G
Sbjct: 50 TGQVLLDMVHNHLGVTEKEYFGL----QHDDDSVDSPRWLEA--SKAIRKQLKGG----- 98
Query: 135 APFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQADL 194
P RV+ ++ + + + RHLY+ LK + + + +LA+ A+Q+
Sbjct: 99 FPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHF 158
Query: 195 GEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQEAC 254
G++ S H Y + P + D++ + + +LH + GL EA C+I A
Sbjct: 159 GDYNSSIHHPGYLSDSHFIPD-----QNEDFLTK-VESLHEQHSGLKQSEAESCYINIAR 212
Query: 255 RLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ 290
L+ V LH + +++G+A GV +Y+
Sbjct: 213 TLDFYGV---ELHSGRDLHNLDLMIGIASAGVAVYR 245
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 61.6 bits (148), Expect = 2e-09
Identities = 51/216 (23%), Positives = 95/216 (43%), Gaps = 20/216 (9%)
Query: 75 TGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKPR 134
TG+ L V N + + ++FGL ++ +D + L SK +K+ G
Sbjct: 50 TGQVLLDMVHNHLGVTEKEYFGL----QHDDDSVDSPRWLEA--SKAIRKQLKGG----- 98
Query: 135 APFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQADL 194
P RV+ ++ + + + RHLY+ LK + + + +LA+ A+Q+
Sbjct: 99 FPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHF 158
Query: 195 GEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQEAC 254
G++ S H Y + P + D++ + + +LH + GL EA C+I A
Sbjct: 159 GDYNSSIHHPGYLSDSHFIPD-----QNEDFLTK-VESLHEQHSGLKQSEAESCYINIAR 212
Query: 255 RLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ 290
L+ V LH + +++G+A GV +Y+
Sbjct: 213 TLDFYGV---ELHSGRDLHNLDLMIGIASAGVAVYR 245
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 60.8 bits (146), Expect = 3e-09
Identities = 64/267 (23%), Positives = 110/267 (41%), Gaps = 32/267 (11%)
Query: 48 AMASEHRDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIF 107
+++ E R + LL E + + + G+ L +CN S+ + +FG+ +
Sbjct: 27 SLSQEMRCTIRLLDDSE-ISCHIQRETKGQFLIDHICNYYSLLEKDYFGIR--------Y 77
Query: 108 MDLEQKLSKYFSKDWKKERNE--GNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCH 165
+D E++ + W + K P+ RV+ Y I + R+L Y
Sbjct: 78 VDPEKQ------RHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQ 131
Query: 166 LKERVLRSQ--CAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGI 223
+K + + C+ + AY L AC +QA+LG++ H P +Y ++ I +
Sbjct: 132 IKRDIFHGRLLCSFSDAAY--LGACIVQAELGDYDPDEH------PENYISEFEIFPKQS 183
Query: 224 DYILRHMPTLHR-ERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLA 282
+ R + +H+ E +G SP A + +A LE V H K T LG
Sbjct: 184 QKLERKIVEIHKNELRGQSPPVAEFNLLLKAHTLETYGVD---PHPCKDSTGTTTFLGFT 240
Query: 283 LRGVHIYQGKKLEIQLDGLPAAQKLVY 309
G ++QG K I L P KL +
Sbjct: 241 AAGFVVFQGNK-RIHLIKWPDVCKLKF 266
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 60.1 bits (144), Expect = 5e-09
Identities = 48/202 (23%), Positives = 93/202 (46%), Gaps = 15/202 (7%)
Query: 58 VLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVV-RNNEYIFMDLEQKLSK 116
+ L + E + + V++TG+E + V +R+ +F L + N+ ++DLE+ L K
Sbjct: 27 IQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLKK 86
Query: 117 YFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCA 176
K P V F V YV + + R+ YY LK+ +L
Sbjct: 87 QLDK-----------YALEPTVYF-GVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIP 134
Query: 177 HREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFP-QWIITKRGIDYILRHMPTLHR 235
E LA A+QAD G+ + + + + + FP W+ ++ ++ + + LH+
Sbjct: 135 CTLEQAIQLAGLAVQADFGDF-DQYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQ 193
Query: 236 ERQGLSPKEAMLCFIQEACRLE 257
+ +GL+ +A + ++QE R++
Sbjct: 194 KYRGLTAPDAEMLYMQEVERMD 215
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 60.1 bits (144), Expect = 5e-09
Identities = 39/161 (24%), Positives = 79/161 (49%), Gaps = 9/161 (5%)
Query: 132 KPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQ 191
K +P+ RV+ +V + + + R+ Y+ +K+ +L + LLA+ A+Q
Sbjct: 96 KRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQ 155
Query: 192 ADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQ 251
++LG++ +S + Y +S+ P + D+ + + LH++ GLSP EA ++
Sbjct: 156 SELGDYDQSENLSGYLSDYSFIP-----NQPQDF-EKEIAKLHQQHIGLSPAEAEFNYLN 209
Query: 252 EACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGK 292
A LE V F H + + +++G+ G+ IY+ +
Sbjct: 210 TARTLELYGVEF---HYARDQSNNEIMIGVMSGGILIYKNR 247
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 59.3 bits (142), Expect = 9e-09
Identities = 73/322 (22%), Positives = 130/322 (40%), Gaps = 39/322 (12%)
Query: 3 VPPRGRGIDPARTNP------DTFPPSGARCMEPSPERPACSQQEPTLGMDA------MA 50
V P G G A +N DT P + ME A E T A +A
Sbjct: 32 VTPAGHGHPEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPSKAQKSPQKIA 91
Query: 51 SEHRDVL--VLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFM 108
+++ + V L + V G+ LF VC ++ + +FGL F
Sbjct: 92 KKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLT--------FC 143
Query: 109 DLEQKLSKYFSKDWKKERNEGNEKPRA-PFVAFLRVQHYVENGRVISDHRARHLYYCHLK 167
D + + K+W E ++ R+ P+ V+ Y + +++ R+ L+
Sbjct: 144 DADSQ------KNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLR 197
Query: 168 ERVLRSQCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYIL 227
++ + + LL + A+QA+LG++ H G Y + P T+ + I+
Sbjct: 198 ADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQ--TRELEERIM 255
Query: 228 RHMPTLHRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVH 287
LH+ +G++P EA + F++ A +L ++ LH K ++LG+ G+
Sbjct: 256 E----LHKTYRGMTPGEAEIHFLENAKKLS---MYGVDLHHAKDSEGIDIMLGVCANGLL 308
Query: 288 IYQGKKLEIQLDGLPAAQKLVY 309
IY+ +L I P K+ Y
Sbjct: 309 IYR-DRLRINRFAWPKILKISY 329
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 56.6 bits (135), Expect = 6e-08
Identities = 61/278 (21%), Positives = 119/278 (42%), Gaps = 31/278 (11%)
Query: 35 PACSQQEPTLGMDAMASEHRDVL--VLLPSREQLRLAVGVKATGRELFQQVCNVASIRDA 92
P+ +Q+ P +A +++ + V L + V G+ LF VC ++ +
Sbjct: 18 PSKAQKSP----QKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEK 73
Query: 93 QFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKPRA-PFVAFLRVQHYVENGR 151
+FGL F D + + K+W E ++ R+ P+ V+ Y +
Sbjct: 74 DYFGLT--------FCDADSQ------KNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPA 119
Query: 152 VISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHS 211
+++ R+ L+ ++ + + LL + A+QA+LG++ H G Y
Sbjct: 120 QLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELR 179
Query: 212 YFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKK 271
+ P T+ + I+ LH+ +G++P EA + F++ A +L ++ LH K
Sbjct: 180 FAPNQ--TRELEERIME----LHKTYRGMTPGEAEIHFLENAKKLS---MYGVDLHHAKD 230
Query: 272 EGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVY 309
++LG+ G+ IY+ +L I P K+ Y
Sbjct: 231 SEGIDIMLGVCANGLLIYR-DRLRINRFAWPKILKISY 267
>gi|38788243 myosin regulatory light chain interacting protein [Homo
sapiens]
Length = 445
Score = 55.8 bits (133), Expect = 1e-07
Identities = 52/249 (20%), Positives = 98/249 (39%), Gaps = 26/249 (10%)
Query: 58 VLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNN-EYIFMDLEQKLSK 116
V P + + V KA G + QVC I + +FGL + E ++++L ++S+
Sbjct: 5 VTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQ 64
Query: 117 YFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCA 176
AP+ LRV+ +VE ++ + + RH+++ H+KE +L
Sbjct: 65 QMDG-------------LAPYRLKLRVKFFVEPHLILQE-QTRHIFFLHIKEALLAGHLL 110
Query: 177 HREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRE 236
E L+A Q G++ ++ Y E + K L + H+E
Sbjct: 111 CSPEQAVELSALLAQTKFGDYNQNTAKYNYEE--------LCAKELSSATLNSIVAKHKE 162
Query: 237 RQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEI 296
+G S A +Q +E+ + + H + +++G+ G+ I + I
Sbjct: 163 LEGTSQASAEYQVLQIVSAMENYGIEW---HSVRDSEGQKLLIGVGPEGISICKDDFSPI 219
Query: 297 QLDGLPAAQ 305
P Q
Sbjct: 220 NRIAYPVVQ 228
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 55.5 bits (132), Expect = 1e-07
Identities = 55/242 (22%), Positives = 108/242 (44%), Gaps = 25/242 (10%)
Query: 58 VLLPSREQLRLAV---GVKAT--GRELFQQVCNVASIRDAQFFGLCVV-RNNEYIFMDLE 111
VLL +L L G+K + G + V + ++ + +FGL R+++ ++D
Sbjct: 15 VLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPA 74
Query: 112 QKLSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVL 171
+ L+++ K+ N G P+ + ++ Y E+ + + R+ ++ +K+ VL
Sbjct: 75 KTLAEH-----KELINTG-----PPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVL 124
Query: 172 RSQCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMP 231
+ + L A A+Q++LG++ H Y + + P K ++ +
Sbjct: 125 QGRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPD---QKEELEEAIER-- 179
Query: 232 TLHRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQG 291
+H+ G P EA L +++ A LE ++ LH E + LGL GV +Y+
Sbjct: 180 -IHKTLMGQIPSEAELNYLRTAKSLE---MYGVDLHPVYGENKSEYFLGLTPVGVVVYKN 235
Query: 292 KK 293
KK
Sbjct: 236 KK 237
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 53.9 bits (128), Expect = 4e-07
Identities = 55/253 (21%), Positives = 107/253 (42%), Gaps = 25/253 (9%)
Query: 58 VLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKY 117
V+L + V ++ G+ LF +VC ++ + +FGL + D E +
Sbjct: 114 VILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLT--------YRDAENQ---- 161
Query: 118 FSKDWKKERNEGNEKPRAPFVAF-LRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCA 176
K+W E ++ R+ F V+ Y + +S+ R+ L++ ++ +
Sbjct: 162 --KNWLDPAKEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLP 219
Query: 177 HREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRE 236
LL + +Q++LG++ Y + P TK D ++ LH+
Sbjct: 220 CSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNH--TKELEDKVIE----LHKS 273
Query: 237 RQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEI 296
+G++P EA + F++ A +L ++ LH K ++LG+ G+ IY+ +L I
Sbjct: 274 HRGMTPAEAEMHFLENAKKLS---MYGVDLHHAKDSEGVEIMLGVCASGLLIYR-DRLRI 329
Query: 297 QLDGLPAAQKLVY 309
P K+ Y
Sbjct: 330 NRFAWPKVLKISY 342
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 52.8 bits (125), Expect = 8e-07
Identities = 52/237 (21%), Positives = 100/237 (42%), Gaps = 25/237 (10%)
Query: 74 ATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKP 133
A G++L ++VC ++ + +FGL + N SK W E ++
Sbjct: 21 AKGQDLLKRVCEHLNLLEEDYFGLAIWDNAT--------------SKTWLDSAKEIKKQV 66
Query: 134 R-APFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACALQA 192
R P+ V+ Y + +++ R+ L++ ++ + LL + +Q+
Sbjct: 67 RGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
Query: 193 DLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQE 252
+LG++ H Y P TK + ++ LH+ + ++P +A L F++
Sbjct: 127 ELGDYDPELHGVDYVSDFKLAPNQ--TKELEEKVME----LHKSYRSMTPAQADLEFLEN 180
Query: 253 ACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDGLPAAQKLVY 309
A +L ++ LHK K +ILG+ G+ +Y+ KL I P K+ Y
Sbjct: 181 AKKLS---MYGVDLHKAKDLEGVDIILGVCSSGLLVYK-DKLRINRFPWPKVLKISY 233
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,521,868
Number of Sequences: 37866
Number of extensions: 1145239
Number of successful extensions: 4043
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 3918
Number of HSP's gapped (non-prelim): 118
length of query: 549
length of database: 18,247,518
effective HSP length: 107
effective length of query: 442
effective length of database: 14,195,856
effective search space: 6274568352
effective search space used: 6274568352
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.