Search of human proteins with 170784838

Search of human proteins with 170784838

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|170784838 secreted frizzled-related  protein 4 [Homo
sapiens]
         (346 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]      727   0.0  
gi|38455388 frizzled-related protein [Homo sapiens]                   316   2e-86
gi|27894385 frizzled 5 precursor [Homo sapiens]                       133   3e-31
gi|13994190 frizzled 8 [Homo sapiens]                                 121   1e-27
gi|4503835 frizzled 9 [Homo sapiens]                                  120   1e-27
gi|4503825 frizzled 1 [Homo sapiens]                                  120   2e-27
gi|4503833 frizzled 7 [Homo sapiens]                                  119   3e-27
gi|4503827 frizzled 2 [Homo sapiens]                                  117   2e-26
gi|6005762 frizzled 10 [Homo sapiens]                                 113   2e-25
gi|22547161 frizzled 4 [Homo sapiens]                                 105   8e-23
gi|8393378 frizzled 3 [Homo sapiens]                                  103   3e-22
gi|34734079 frizzled 6 [Homo sapiens]                                  89   6e-18
gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]         88   1e-17
gi|29244926 corin [Homo sapiens]                                       84   2e-16
gi|48475052 secreted frizzled-related protein 2 precursor [Homo ...    81   2e-15
gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]        80   3e-15
gi|13899255 membrane frizzled-related protein [Homo sapiens]           66   5e-11
gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]      56   4e-08
gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]                56   4e-08
gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho...    54   3e-07
gi|5032099 smoothened [Homo sapiens]                                   43   5e-04
gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform...    37   0.026
gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ...    37   0.026
gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ...    37   0.026
gi|110349719 titin isoform N2-A [Homo sapiens]                         35   0.099
gi|187761324 shootin1 isoform a [Homo sapiens]                         34   0.17 
gi|50511340 shootin1 isoform b [Homo sapiens]                          34   0.17 
gi|7657269 PDS5, regulator of cohesion maintenance, homolog B [H...    34   0.22 
gi|191252785 centrobin, centrosomal BRCA2 interacting protein is...    34   0.22 
gi|80861396 centrobin, centrosomal BRCA2 interacting protein iso...    34   0.22 

>gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]
          Length = 346

 Score =  727 bits (1877), Expect = 0.0
 Identities = 346/346 (100%), Positives = 346/346 (100%)

Query: 1   MFLSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQ 60
           MFLSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQ
Sbjct: 1   MFLSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQ 60

Query: 61  YEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWP 120
           YEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWP
Sbjct: 61  YEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWP 120

Query: 121 ESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMMVQERPLDVDCKRLSPDRCKC 180
           ESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMMVQERPLDVDCKRLSPDRCKC
Sbjct: 121 ESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMMVQERPLDVDCKRLSPDRCKC 180

Query: 181 KKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSSSPIPRTQVPLITN 240
           KKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSSSPIPRTQVPLITN
Sbjct: 181 KKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSSSPIPRTQVPLITN 240

Query: 241 SSCQCPHILPHQDVLIMCYEWRSRMMLLENCLVEKWRDQLSKRSIQWEERLQEQRRTVQD 300
           SSCQCPHILPHQDVLIMCYEWRSRMMLLENCLVEKWRDQLSKRSIQWEERLQEQRRTVQD
Sbjct: 241 SSCQCPHILPHQDVLIMCYEWRSRMMLLENCLVEKWRDQLSKRSIQWEERLQEQRRTVQD 300

Query: 301 KKKTAGRTSRSNPPKPKGKPPAPKPASPKKNIKTRSAQKRTNPKRV 346
           KKKTAGRTSRSNPPKPKGKPPAPKPASPKKNIKTRSAQKRTNPKRV
Sbjct: 301 KKKTAGRTSRSNPPKPKGKPPAPKPASPKKNIKTRSAQKRTNPKRV 346


>gi|38455388 frizzled-related protein [Homo sapiens]
          Length = 325

 Score =  316 bits (809), Expect = 2e-86
 Identities = 161/317 (50%), Positives = 212/317 (66%), Gaps = 25/317 (7%)

Query: 3   LSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYE 62
           L  L ALCL      G R A CE VRIP+C+ +PWN+T+MPNHLHHSTQ NAILAIEQ+E
Sbjct: 16  LLALAALCLLR--VPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFE 73

Query: 63  ELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPES 122
            L+  +CS  L FFLCAMYAPICT++F H+PIKPCKSVC+RAR  CEP++  Y HSWPE+
Sbjct: 74  GLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPEN 133

Query: 123 LACDELPVYDRGVCISPEAIVT----DLPEDVKWIDITPDMMVQERPLDVDCKRLSPDRC 178
           LAC+ELPVYDRGVCISPEAIVT    D P D                 + +C+  S +RC
Sbjct: 134 LACEELPVYDRGVCISPEAIVTADGADFPMDSS---------------NGNCRGASSERC 178

Query: 179 KCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSS-SPIPRTQVPL 237
           KCK ++ T  TY   NY+YVI AK+K + ++ C++VT VV+VKEI KSS   IPR  V L
Sbjct: 179 KCKPIRATQKTYFRNNYNYVIRAKVKEI-KTKCHDVTAVVEVKEILKSSLVNIPRDTVNL 237

Query: 238 ITNSSCQCPHILPHQDVLIMCY--EWRSRMMLLENCLVEKWRDQLSKRSIQWEERLQEQR 295
            T+S C CP +  +++ +IM Y  E RSR++L+E  + EKW+D+L K+  +W+ +L+   
Sbjct: 238 YTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLG 297

Query: 296 RTVQDKKKTAGRTSRSN 312
            +  D   +    S+ +
Sbjct: 298 LSKSDSSNSDSTQSQKS 314


>gi|27894385 frizzled 5 precursor [Homo sapiens]
          Length = 585

 Score =  133 bits (334), Expect = 3e-31
 Identities = 59/130 (45%), Positives = 85/130 (65%), Gaps = 2/130 (1%)

Query: 5   ILVALCLWLHLALGVRGAP-CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEE 63
           +L+ L   +  A     AP C+ + +PMCR + +N+T MPN  +H TQ+ A L + Q+  
Sbjct: 13  LLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWP 72

Query: 64  LVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESL 123
           LV++ CS  LRFFLC+MY PIC  ++ H P+ PC+SVC+RA+  C PLM+ Y  +WPE +
Sbjct: 73  LVEIQCSPDLRFFLCSMYTPICLPDY-HKPLPPCRSVCERAKAGCSPLMRQYGFAWPERM 131

Query: 124 ACDELPVYDR 133
           +CD LPV  R
Sbjct: 132 SCDRLPVLGR 141


>gi|13994190 frizzled 8 [Homo sapiens]
          Length = 694

 Score =  121 bits (303), Expect = 1e-27
 Identities = 55/130 (42%), Positives = 80/130 (61%), Gaps = 5/130 (3%)

Query: 4   SILVALCLWLH----LALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIE 59
           S+L AL L        A   +   C+ + +P+C+ + +N T MPN  +H TQ+ A L + 
Sbjct: 11  SLLAALALLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVH 70

Query: 60  QYEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSW 119
           Q+  LV++ CS  L+FFLC+MY PIC LE    P+ PC+SVC+RA+  C PLM+ Y  +W
Sbjct: 71  QFWPLVEIQCSPDLKFFLCSMYTPIC-LEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAW 129

Query: 120 PESLACDELP 129
           P+ + CD LP
Sbjct: 130 PDRMRCDRLP 139


>gi|4503835 frizzled 9 [Homo sapiens]
          Length = 591

 Score =  120 bits (302), Expect = 1e-27
 Identities = 64/156 (41%), Positives = 91/156 (58%), Gaps = 20/156 (12%)

Query: 8   ALCLWLHLALG-----------VRG---APCEAVRIPMCRHMPWNITRMPNHLHHSTQEN 53
           AL LW  LA G            RG   APC+AV IPMCR + +N+TRMPN L H++Q  
Sbjct: 9   ALLLWQLLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGE 68

Query: 54  AILAIEQYEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMK 113
           A   + ++  LV   C + LRFFLC++YAP+CT + +  PI  C+ +C++AR  C P+M+
Sbjct: 69  AAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCT-DQVSTPIPACRPMCEQARLRCAPIME 127

Query: 114 MYNHSWPESLACDELPVYDRGVCISPEAIVTDLPED 149
            +N  WP+SL C  LP  +      P A+  + PE+
Sbjct: 128 QFNFGWPDSLDCARLPTRN-----DPHALCMEAPEN 158


>gi|4503825 frizzled 1 [Homo sapiens]
          Length = 647

 Score =  120 bits (301), Expect = 2e-27
 Identities = 53/115 (46%), Positives = 78/115 (67%), Gaps = 3/115 (2%)

Query: 24  CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAP 83
           C+ + IP+C  + +N T MPN L H+ QE+A L + Q+  LV V CSA L+FFLC+MYAP
Sbjct: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175

Query: 84  ICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRG-VCI 137
           +CT+  L   + PC+S+C+RAR  CE LM  +   WP++L C++ PV+  G +C+
Sbjct: 176 VCTV--LEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCV 228


>gi|4503833 frizzled 7 [Homo sapiens]
          Length = 574

 Score =  119 bits (299), Expect = 3e-27
 Identities = 54/115 (46%), Positives = 75/115 (65%), Gaps = 3/115 (2%)

Query: 24  CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAP 83
           C+ + IP+C  + +N T +PN L H+ QE+A L + Q+  LV V CS  LRFFLC+MYAP
Sbjct: 49  CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 108

Query: 84  ICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRG-VCI 137
           +CT+  L   I PC+S+C+RAR  CE LM  +   WPE L C+  PV+  G +C+
Sbjct: 109 VCTV--LDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICV 161


>gi|4503827 frizzled 2 [Homo sapiens]
          Length = 565

 Score =  117 bits (292), Expect = 2e-26
 Identities = 52/106 (49%), Positives = 69/106 (65%), Gaps = 2/106 (1%)

Query: 24  CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAP 83
           C+ + IP+C  + +N T MPN L H+ QE+A L + Q+  LV V CS  LRFFLC+MYAP
Sbjct: 39  CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 98

Query: 84  ICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELP 129
           +CT+  L   I PC+S+C+RAR  CE LM  +   WPE L C+  P
Sbjct: 99  VCTV--LEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFP 142


>gi|6005762 frizzled 10 [Homo sapiens]
          Length = 581

 Score =  113 bits (283), Expect = 2e-25
 Identities = 52/142 (36%), Positives = 83/142 (58%), Gaps = 1/142 (0%)

Query: 24  CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAP 83
           C+ + IPMC+ + +N+TRMPN + H  Q  A + + ++  LV+  C   LRFFLC++YAP
Sbjct: 34  CQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAP 93

Query: 84  ICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIV 143
           +CT E +  PI  C+ +C++AR  C P+M+ +N  WP+SL C +LP  +    +  EA  
Sbjct: 94  MCT-EQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPN 152

Query: 144 TDLPEDVKWIDITPDMMVQERP 165
               E  +   + P +   +RP
Sbjct: 153 NGSDEPTRGSGLFPPLFRPQRP 174


>gi|22547161 frizzled 4 [Homo sapiens]
          Length = 537

 Score =  105 bits (261), Expect = 8e-23
 Identities = 50/130 (38%), Positives = 79/130 (60%), Gaps = 4/130 (3%)

Query: 3   LSILVALCLWLHLALGVRGAP---CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIE 59
           L +L+ L L L  A G        C+ +RI MC+++ +N+T+MPN + H  Q +A L + 
Sbjct: 21  LGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLT 80

Query: 60  QYEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSW 119
            +  L+   CS+ L+FFLC++Y P+CT E ++ PI PC  +C   +  CEP++K +  +W
Sbjct: 81  TFTPLIQYGCSSQLQFFLCSVYVPMCT-EKINIPIGPCGGMCLSVKRRCEPVLKEFGFAW 139

Query: 120 PESLACDELP 129
           PESL C + P
Sbjct: 140 PESLNCSKFP 149


>gi|8393378 frizzled 3 [Homo sapiens]
          Length = 666

 Score =  103 bits (256), Expect = 3e-22
 Identities = 47/109 (43%), Positives = 70/109 (64%), Gaps = 2/109 (1%)

Query: 24  CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAP 83
           CE + + MC+ +P+N T MPN L+H  Q+ A LA+E +  +V+++CS   R FLCA+YAP
Sbjct: 28  CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87

Query: 84  ICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYD 132
           IC +E+    + PC+ +CQRA  +C  LM+M+   WPE + C   P  D
Sbjct: 88  IC-MEYGRVTL-PCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCD 134


>gi|34734079 frizzled 6 [Homo sapiens]
          Length = 706

 Score = 89.0 bits (219), Expect = 6e-18
 Identities = 45/138 (32%), Positives = 72/138 (52%), Gaps = 4/138 (2%)

Query: 1   MFLSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQ 60
           MF  +L   C++L L  G     CE + +P C  M +N+T  PN + H  Q  A + +E 
Sbjct: 3   MFTFLLT--CIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEH 60

Query: 61  YEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWP 120
           +  L ++ CS  +  FLC  + P C +E +H  + PC+ +C++   DC+ L+  +   WP
Sbjct: 61  FLPLANLECSPNIETFLCKAFVPTC-IEQIH-VVPPCRKLCEKVYSDCKKLIDTFGIRWP 118

Query: 121 ESLACDELPVYDRGVCIS 138
           E L CD L   D  V ++
Sbjct: 119 EELECDRLQYCDETVPVT 136


>gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]
          Length = 314

 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 53/169 (31%), Positives = 81/169 (47%), Gaps = 13/169 (7%)

Query: 23  PCEAVRIP----MCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLC 78
           P + V IP    +C ++ +    +PN L H T          +  L++ NC A  + FLC
Sbjct: 55  PPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLC 114

Query: 79  AMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCIS 138
           +++AP+C    L  PI PC+ +C+  RD CEP+M+ +   WPE L CD+ P  D  VCI+
Sbjct: 115 SLFAPVC----LDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGD--VCIA 168

Query: 139 ---PEAIVTDLPEDVKWIDITPDMMVQERPLDVDCKRLSPDRCKCKKVK 184
              P A     P+         + +  E  ++  C      R K K+VK
Sbjct: 169 MTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVK 217


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 38/126 (30%), Positives = 66/126 (52%), Gaps = 5/126 (3%)

Query: 24  CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQ--YEELVDVNCSAVLRFFLCAMY 81
           CE + + +C ++P+N T  PN+  H TQ+ A ++ E   +  LV  NC   L FF C + 
Sbjct: 455 CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTIL 514

Query: 82  APICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPV--YDRGVCISP 139
            P C +    + I PC+++C+ +++ CE ++ +    WPE   C + P    D   C+ P
Sbjct: 515 VPKCDVN-TGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMP 573

Query: 140 EAIVTD 145
           +  V +
Sbjct: 574 DEYVEE 579



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 30/124 (24%), Positives = 56/124 (45%), Gaps = 9/124 (7%)

Query: 24  CEAVRIPMCRHMPWNITRMPN-HLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYA 82
           C  +    C+ +P++ T  P   +  + +    L    Y  L  ++C   +  F C +  
Sbjct: 139 CMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTY--LHRLSCYQHIMLFGCTLAF 196

Query: 83  PICTLEFLHDP-IKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRG-----VC 136
           P C ++      + PC+S C+ A++ CE ++ M N+SWP+ L C +            +C
Sbjct: 197 PECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRIC 256

Query: 137 ISPE 140
            SP+
Sbjct: 257 FSPQ 260


>gi|48475052 secreted frizzled-related protein 2 precursor [Homo
           sapiens]
          Length = 295

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 48/183 (26%), Positives = 86/183 (46%), Gaps = 9/183 (4%)

Query: 29  IPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAPICTLE 88
           + +C  + +   R+PN L H T +  +     +  LV   C    + FLC+++AP+C L+
Sbjct: 47  LQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVC-LD 105

Query: 89  FLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPE 148
            L + I+PC S+C + +D C P+M  +   WP+ L CD  P  D  +CI   +    LP 
Sbjct: 106 DLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFP-QDNDLCIPLASSDHLLPA 164

Query: 149 DVKWIDITPDMMVQERPLDVDCKRLSPDRCK---CKKVKPTLATYLSKNYSYVIHAKIKA 205
                +  P +    +  + D   +    CK     K+K    TY++++   ++  K K 
Sbjct: 165 ----TEEAPKVCEACKNKNDDDNDIMETLCKNDFALKIKVKEITYINRDTKIILETKSKT 220

Query: 206 VQR 208
           + +
Sbjct: 221 IYK 223


>gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]
          Length = 317

 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 37/110 (33%), Positives = 59/110 (53%), Gaps = 5/110 (4%)

Query: 29  IPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAPICTLE 88
           +P+C  + +   R+PN L H +          +  L+   C +  + FLC+++AP+C   
Sbjct: 60  LPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVC--- 116

Query: 89  FLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCIS 138
            L  PI PC+S+C+  R  C PLM+ Y   WPE L C + P+ D  +CI+
Sbjct: 117 -LDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPL-DNDLCIA 164


>gi|13899255 membrane frizzled-related protein [Homo sapiens]
          Length = 579

 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 38/118 (32%), Positives = 54/118 (45%), Gaps = 6/118 (5%)

Query: 24  CEAVRIPMCRHMPWNITRMPN-HLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYA 82
           CE V++ MC  + +N T  PN  +   TQE  +  +  Y+ L  + C    R  LC +  
Sbjct: 466 CEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLV 525

Query: 83  PICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELP-VYDRGVCISP 139
           P CT   L   + PC+SVCQ A   C+  + +    WP    C+ LP   D   C  P
Sbjct: 526 PRCTP--LGSVLPPCRSVCQEAEHQCQSGLALLGTPWP--FNCNRLPEAADLEACAQP 579


>gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]
          Length = 641

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 31/123 (25%), Positives = 55/123 (44%), Gaps = 8/123 (6%)

Query: 22  APCEAVRIPMCRHMPWNITRMPNHLHHSTQE-----NAILAIEQYEELVDVNCSAVLRFF 76
           A C  +++  C    +N T  PN L H + E     +  + +    +L++  C+  LR  
Sbjct: 30  ATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLL 89

Query: 77  LCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVC 136
            CA+ AP C   ++    +PC+ +C+  R+ C+P     + +WP  L C      +   C
Sbjct: 90  GCAVLAPRCEGGWVR---RPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGC 146

Query: 137 ISP 139
             P
Sbjct: 147 YDP 149


>gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]
          Length = 652

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 31/123 (25%), Positives = 55/123 (44%), Gaps = 8/123 (6%)

Query: 22  APCEAVRIPMCRHMPWNITRMPNHLHHSTQE-----NAILAIEQYEELVDVNCSAVLRFF 76
           A C  +++  C    +N T  PN L H + E     +  + +    +L++  C+  LR  
Sbjct: 41  ATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLL 100

Query: 77  LCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVC 136
            CA+ AP C   ++    +PC+ +C+  R+ C+P     + +WP  L C      +   C
Sbjct: 101 GCAVLAPRCEGGWVR---RPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGC 157

Query: 137 ISP 139
             P
Sbjct: 158 YDP 160


>gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo
           sapiens]
          Length = 1751

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 34/135 (25%), Positives = 57/135 (42%), Gaps = 5/135 (3%)

Query: 29  IPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAPICTLE 88
           +P+C H+  +   +PNHLHH + E        +  L+  +C   L +F C +  P C   
Sbjct: 341 LPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCLLLVPPCGSV 400

Query: 89  FLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPE 148
               P  PC   C+  +D C    ++     P  +AC  LP  + G C+        + E
Sbjct: 401 PPPAP-PPCCQFCEALQDAC--WSRLGGGRLP--VACASLPTQEDGYCVLIGPAAERISE 455

Query: 149 DVKWIDITPDMMVQE 163
           +V  + +  D   Q+
Sbjct: 456 EVGLLQLLGDPPPQQ 470


>gi|5032099 smoothened [Homo sapiens]
          Length = 787

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 10/110 (9%)

Query: 20  RGAPCEAVRIPMCRH--MPWNITRMPNHLHHSTQENAILAIEQYEELVDV-NCSAVLRFF 76
           R APCE +R  +C    +P+  T         +QE A   +  +  L +   C AV++  
Sbjct: 66  RAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPL 125

Query: 77  LCAMYAPICTLEFLHDPIK-PCKSVCQRARDDCEPLMKMYNHSWPESLAC 125
           LCA+Y P C     +D ++ P +++CQ  R  C  + +     WP+ L C
Sbjct: 126 LCAVYMPKCE----NDRVELPSRTLCQATRGPCAIVER--ERGWPDFLRC 169


>gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c
           precursor [Homo sapiens]
          Length = 899

 Score = 37.0 bits (84), Expect = 0.026
 Identities = 19/59 (32%), Positives = 29/59 (49%)

Query: 272 LVEKWRDQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSRSNPPKPKGKPPAPKPASPKK 330
           L+EK   +L K   + EER+ E R  +Q +++   R     PP+P G  P   P  P +
Sbjct: 828 LLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDR 886


>gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b
           precursor [Homo sapiens]
          Length = 844

 Score = 37.0 bits (84), Expect = 0.026
 Identities = 19/59 (32%), Positives = 29/59 (49%)

Query: 272 LVEKWRDQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSRSNPPKPKGKPPAPKPASPKK 330
           L+EK   +L K   + EER+ E R  +Q +++   R     PP+P G  P   P  P +
Sbjct: 773 LLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDR 831


>gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a
           precursor [Homo sapiens]
          Length = 961

 Score = 37.0 bits (84), Expect = 0.026
 Identities = 19/59 (32%), Positives = 29/59 (49%)

Query: 272 LVEKWRDQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSRSNPPKPKGKPPAPKPASPKK 330
           L+EK   +L K   + EER+ E R  +Q +++   R     PP+P G  P   P  P +
Sbjct: 890 LLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDR 948


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 35.0 bits (79), Expect = 0.099
 Identities = 18/66 (27%), Positives = 32/66 (48%), Gaps = 12/66 (18%)

Query: 292   QEQRRTVQDKKKTAGRTSRSNPPKP------------KGKPPAPKPASPKKNIKTRSAQK 339
             +E ++ + +KK    +   + PPK             K +PP P PA PK+++K +  Q 
Sbjct: 10841 EEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQL 10900

Query: 340   RTNPKR 345
             +  PK+
Sbjct: 10901 KAIPKK 10906


>gi|187761324 shootin1 isoform a [Homo sapiens]
          Length = 631

 Score = 34.3 bits (77), Expect = 0.17
 Identities = 18/72 (25%), Positives = 34/72 (47%)

Query: 272 LVEKWRDQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSRSNPPKPKGKPPAPKPASPKKN 331
           L+E+ + +L  +    EE+ +  + +V + +K   ++  S PP P   PP P P      
Sbjct: 312 LLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIR 371

Query: 332 IKTRSAQKRTNP 343
                 +KR++P
Sbjct: 372 SLMSMIRKRSHP 383


>gi|50511340 shootin1 isoform b [Homo sapiens]
          Length = 456

 Score = 34.3 bits (77), Expect = 0.17
 Identities = 18/72 (25%), Positives = 34/72 (47%)

Query: 272 LVEKWRDQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSRSNPPKPKGKPPAPKPASPKKN 331
           L+E+ + +L  +    EE+ +  + +V + +K   ++  S PP P   PP P P      
Sbjct: 312 LLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIR 371

Query: 332 IKTRSAQKRTNP 343
                 +KR++P
Sbjct: 372 SLMSMIRKRSHP 383


>gi|7657269 PDS5, regulator of cohesion maintenance, homolog B [Homo
            sapiens]
          Length = 1447

 Score = 33.9 bits (76), Expect = 0.22
 Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 4/66 (6%)

Query: 278  DQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSRSNPPKPKGKPP-APKPASPKKNIKT-R 335
            +Q SK       R  +QR   +  + +A  +++S P K +G+P   P P+ PKKN++  R
Sbjct: 1338 EQKSKSKQHRVSRRAQQR--AESPESSAIESTQSTPQKGRGRPSKTPSPSQPKKNVRVGR 1395

Query: 336  SAQKRT 341
            S Q  T
Sbjct: 1396 SKQAAT 1401


>gi|191252785 centrobin, centrosomal BRCA2 interacting protein
           isoform alpha [Homo sapiens]
          Length = 903

 Score = 33.9 bits (76), Expect = 0.22
 Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 2/74 (2%)

Query: 259 YEWRSRMMLLENCLVEKWRDQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSRS--NPPKP 316
           YE R        C ++    QL ++ ++  ERLQ   +   D+      T+    NPP P
Sbjct: 521 YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAP 580

Query: 317 KGKPPAPKPASPKK 330
              P +P P  P+K
Sbjct: 581 PAGPSSPGPQEPEK 594


>gi|80861396 centrobin, centrosomal BRCA2 interacting protein
           isoform beta [Homo sapiens]
          Length = 925

 Score = 33.9 bits (76), Expect = 0.22
 Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 2/74 (2%)

Query: 259 YEWRSRMMLLENCLVEKWRDQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSRS--NPPKP 316
           YE R        C ++    QL ++ ++  ERLQ   +   D+      T+    NPP P
Sbjct: 521 YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAP 580

Query: 317 KGKPPAPKPASPKK 330
              P +P P  P+K
Sbjct: 581 PAGPSSPGPQEPEK 594


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.134    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,002,279
Number of Sequences: 37866
Number of extensions: 729649
Number of successful extensions: 6347
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 6015
Number of HSP's gapped (non-prelim): 331
length of query: 346
length of database: 18,247,518
effective HSP length: 103
effective length of query: 243
effective length of database: 14,347,320
effective search space: 3486398760
effective search space used: 3486398760
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.