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Search of human proteins with 169217528
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169217528 PREDICTED: similar to sidekick homolog 2 (chicken)
[Homo sapiens]
(399 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169217528 PREDICTED: similar to sidekick homolog 2 (chicken) ... 822 0.0
gi|222352127 sidekick 2 [Homo sapiens] 582 e-166
gi|119220552 sidekick 1 [Homo sapiens] 315 4e-86
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 138 8e-33
gi|75709184 contactin 3 [Homo sapiens] 132 4e-31
gi|118572606 hemicentin 1 [Homo sapiens] 128 8e-30
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 127 2e-29
gi|7657361 contactin 6 [Homo sapiens] 125 9e-29
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 122 4e-28
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 122 4e-28
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 122 4e-28
gi|4827022 contactin 2 precursor [Homo sapiens] 117 2e-26
gi|28373126 contactin 4 isoform c precursor [Homo sapiens] 116 3e-26
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 116 4e-26
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 115 5e-26
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 115 5e-26
gi|109150416 peroxidasin [Homo sapiens] 114 1e-25
gi|19743806 roundabout 1 isoform b [Homo sapiens] 112 8e-25
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 112 8e-25
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 112 8e-25
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 112 8e-25
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 112 8e-25
gi|4506569 roundabout 1 isoform a [Homo sapiens] 112 8e-25
gi|126517478 peroxidasin homolog-like [Homo sapiens] 111 1e-24
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] 110 2e-24
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] 110 2e-24
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 110 3e-24
gi|7657359 contactin 5 isoform long [Homo sapiens] 108 7e-24
gi|28373129 contactin 5 isoform short [Homo sapiens] 108 7e-24
gi|224994173 roundabout 1 isoform d [Homo sapiens] 106 3e-23
>gi|169217528 PREDICTED: similar to sidekick homolog 2 (chicken)
[Homo sapiens]
Length = 399
Score = 822 bits (2122), Expect = 0.0
Identities = 399/399 (100%), Positives = 399/399 (100%)
Query: 1 MKKLPSVTSSYCHSSRSFPDVCGHRTPFPWGPSEYPHGTSRGPLWKIRPQGPTRPLIKLH 60
MKKLPSVTSSYCHSSRSFPDVCGHRTPFPWGPSEYPHGTSRGPLWKIRPQGPTRPLIKLH
Sbjct: 1 MKKLPSVTSSYCHSSRSFPDVCGHRTPFPWGPSEYPHGTSRGPLWKIRPQGPTRPLIKLH 60
Query: 61 IIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPP 120
IIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPP
Sbjct: 61 IIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPP 120
Query: 121 QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQIS 180
QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQIS
Sbjct: 121 QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQIS 180
Query: 181 GLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGA 240
GLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGA
Sbjct: 181 GLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGA 240
Query: 241 PRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 300
PRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA
Sbjct: 241 PRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 300
Query: 301 DLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGGHWTYDSLYSH 360
DLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGGHWTYDSLYSH
Sbjct: 301 DLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGGHWTYDSLYSH 360
Query: 361 PQMRLRGAQVGTRGSRLLANTDSQRTYQRPQFEKHLMKC 399
PQMRLRGAQVGTRGSRLLANTDSQRTYQRPQFEKHLMKC
Sbjct: 361 PQMRLRGAQVGTRGSRLLANTDSQRTYQRPQFEKHLMKC 399
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 582 bits (1500), Expect = e-166
Identities = 295/314 (93%), Positives = 299/314 (95%), Gaps = 9/314 (2%)
Query: 54 RPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY 113
RPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY
Sbjct: 242 RPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY 301
Query: 114 LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN 173
LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN
Sbjct: 302 LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN 361
Query: 174 DGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL 233
DGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL
Sbjct: 362 DGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL 421
Query: 234 ACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSR 293
ACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSR
Sbjct: 422 ACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSR 481
Query: 294 GVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQL--RPGAPSGGH 351
GVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIR + + GA G
Sbjct: 482 GVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTE 541
Query: 352 WTYDSLYSHPQMRL 365
SHP++RL
Sbjct: 542 -------SHPRIRL 548
Score = 89.4 bits (220), Expect = 5e-18
Identities = 78/254 (30%), Positives = 107/254 (42%), Gaps = 17/254 (6%)
Query: 61 IIWKKDGVLLSGGISDHNRR-----LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLS 115
I W KD ++ R+ L I D G ++C A ++ V YL+
Sbjct: 340 ITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFA---RNAAGEVQTSTYLA 396
Query: 116 VLE-PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE--KLTRFRQR 172
V P + P + VV + C+ G P P+ITW K ++ +L RF
Sbjct: 397 VTSIAPNITRGPLDSTVIDGMSVV-LACETSGAPRPAITWQKGERILASGSVQLPRFTPL 455
Query: 173 NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV 232
G L IS D G + C A N+ G + S L V + IT+ P D +VI G
Sbjct: 456 ESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWA-RTRITKPPQDQSVIKGTQAS 514
Query: 233 LACETSGAPRPAIT--WQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLAT 290
+ C + PR I W+K L G+ PR +GSL IS T D GTYTC
Sbjct: 515 MVCGVTHDPRVTIRYIWEKDGATL--GTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVI 572
Query: 291 NSRGVDEASADLVV 304
++ G D SA L V
Sbjct: 573 SAGGNDSRSAHLRV 586
Score = 46.2 bits (108), Expect = 5e-05
Identities = 61/249 (24%), Positives = 100/249 (40%), Gaps = 27/249 (10%)
Query: 80 RLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVD 139
R I + + AG+Y C ++R+ + R + V F + + + E V
Sbjct: 75 RYMITSLDRTHAGFYRC--IVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVI 132
Query: 140 IPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARN-AA 198
+ P P +TW++D ++ +R + L I V D G + A N
Sbjct: 133 RAPRIASFPQPQVTWFRDGR--KIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKN 190
Query: 199 GEVQTSTYLAVT---------SIAPNITRGPLDSTVIDGMS-VVLACETSGAP--RPAIT 246
G+ +TS + +T IAP I P +++V+ G S V L C + P + I
Sbjct: 191 GDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHII 250
Query: 247 WQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWA 306
W+K + +L SG + + L I SDAG Y C A + +V A
Sbjct: 251 WKK-DGVLLSGGIS------DHNRRLTIPNPTGSDAGYYECEAVLR---SSSVPSVVRGA 300
Query: 307 RTRITKPPQ 315
+ +PPQ
Sbjct: 301 YLSVLEPPQ 309
Score = 36.6 bits (83), Expect = 0.041
Identities = 44/164 (26%), Positives = 62/164 (37%), Gaps = 19/164 (11%)
Query: 61 IIWKKDGVLLSGGISDHNRRLTIPN------PTG-SDAGYYECEAVLR---SSSVPSVVR 110
I W+K +L+ G R + + PT SDAG Y C A + +V
Sbjct: 433 ITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVV 492
Query: 111 GAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSIT--WYKDAAVVEVEKLTR 168
A + +PPQ + I +V C P +I W KD A + E R
Sbjct: 493 WARTRITKPPQ----DQSVIKGTQASMV---CGVTHDPRVTIRYIWEKDGATLGTESHPR 545
Query: 169 FRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSI 212
R +G L IS D G + C +A G S +L V +
Sbjct: 546 IRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQL 589
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 315 bits (808), Expect = 4e-86
Identities = 162/328 (49%), Positives = 211/328 (64%), Gaps = 10/328 (3%)
Query: 54 RPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY 113
RP+ L + WK++GV ++ G+ RRLTI NPT +D G Y CEA L S+ A+
Sbjct: 320 RPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAF 379
Query: 114 LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN 173
L ++EPP F EPE I+AE+E+ VDI CQA GVP P++ WYKDA + + R++
Sbjct: 380 LFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLA 439
Query: 174 DGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL 233
GGL+I L P+D+G+FQCFA N GE+QT TYL VT+IAP T+ P+D+TV DGM+ +L
Sbjct: 440 SGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAIL 499
Query: 234 ACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSR 293
CE SGAP+PAITW++ ILASGSV++PRF LESG L I+P I DAG YTC A N+
Sbjct: 500 RCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTE 559
Query: 294 GVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGGHWT 353
G ASA L VW RT I PP+D VIKGT A++ CG THDPRV++R + W
Sbjct: 560 GSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYV---------WK 610
Query: 354 YDSLYSHPQMRLRGAQVGTRGSRLLANT 381
D++ P R V GS L++ T
Sbjct: 611 KDNVALTPSSTSR-IVVEKDGSLLISQT 637
Score = 90.9 bits (224), Expect = 2e-18
Identities = 82/283 (28%), Positives = 121/283 (42%), Gaps = 32/283 (11%)
Query: 68 VLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE-PPQFVKEP 126
VL SGG L I D+G ++C A S+ + YL V P F + P
Sbjct: 437 VLASGG-------LRIQKLRPEDSGIFQCFA---SNEGGEIQTHTYLDVTNIAPVFTQRP 486
Query: 127 -ERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE--KLTRFRQRNDGGLQISGLV 183
+ +T M + + C+ G P P+ITW ++ ++ ++ RF GGLQI+ +
Sbjct: 487 VDTTVTDGMTAI--LRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVF 544
Query: 184 PDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRP 243
D G + C+A N G + S L V + +I P D VI G + L C + PR
Sbjct: 545 IQDAGNYTCYAANTEGSLNASATLTVWN-RTSIVHPPEDHVVIKGTTATLHCGATHDPRV 603
Query: 244 AI--TWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASAD 301
++ W+K L S R + GSLLIS T D G Y+C + G D A
Sbjct: 604 SLRYVWKKDNVALTPSSTS--RIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMAR 661
Query: 302 LVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRP 344
L V I P Q+++ +S H V + +RP
Sbjct: 662 LEV-----IELPHSPQNLLVSPNSS------HSHAVVLSWVRP 693
Score = 47.8 bits (112), Expect = 2e-05
Identities = 54/218 (24%), Positives = 91/218 (41%), Gaps = 27/218 (12%)
Query: 120 PQFVKEPER-HITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQ 178
P F EP I E ++V + C A+G P W +D + +LT + ++
Sbjct: 104 PYFKTEPGLPQIHLEGNRLV-LTCLAEGSWPLEFKWMRDDS-----ELTTYS--SEYKYI 155
Query: 179 ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL-ACET 237
I L D G ++C RN G + + + TV G + +L
Sbjct: 156 IPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPI 215
Query: 238 SGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 296
+ PRP +TW ++G +I+ S + + LE+ L+I T SDAG Y A N + +
Sbjct: 216 TSYPRPQVTWFREGHKIIPSNRIAIT----LEN-QLVILATTTSDAGAYYVQAVNEKNGE 270
Query: 297 EASADLVVWARTR-----------ITKPPQDQSVIKGT 323
++ + + R I PP ++SV+ G+
Sbjct: 271 NKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGS 308
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 138 bits (348), Expect = 8e-33
Identities = 100/285 (35%), Positives = 140/285 (49%), Gaps = 18/285 (6%)
Query: 61 IIWKK-DGVLLSGGISDH--NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL 117
IIW++ DG ++ H N L IPN DAG YEC V +S +V RG
Sbjct: 257 IIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYEC--VAENSRGKNVARGQLTFYA 314
Query: 118 EPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFR-QRNDGG 176
+P K + H+ ME+ V C+A G P P+ W K+ + LTR R Q G
Sbjct: 315 QPNWIQKINDIHVA--MEENVFWECKANGRPKPTYKWLKNGEPL----LTRDRIQIEQGT 368
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID--GMSVVLA 234
L I+ + D GM+QC A N G + ++ L+V ++ P+ +R L + G VV+
Sbjct: 369 LNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIE 428
Query: 235 CETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRG 294
C+ +P+P TW+KG IL R T E G+L I SDAG+YTC+ATN G
Sbjct: 429 CKPKASPKPVYTWKKGRDILKENE----RITISEDGNLRIINVTKSDAGSYTCIATNHFG 484
Query: 295 VDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTI 339
++ +LVV TR+ PP V G + C VTHD + I
Sbjct: 485 TASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDI 529
Score = 68.2 bits (165), Expect = 1e-11
Identities = 73/269 (27%), Positives = 109/269 (40%), Gaps = 19/269 (7%)
Query: 45 WKIRPQGPTRPLIKLHIIWKKDG--VLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRS 102
W+ + G +P K W K+G +L I L I SDAG Y+C A +
Sbjct: 335 WECKANGRPKPTYK----WLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKH 390
Query: 103 SSVPSVVRGAYLSVLEP-PQFVKEPERHIT-AEMEKVVDIPCQAKGVPPPSITWYKDAAV 160
+ S A LSV+ P F + + +T ++ V I C+ K P P TW K +
Sbjct: 391 GVIFS---NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDI 447
Query: 161 VEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGP 220
++ + R DG L+I + D G + C A N G ++ L V + P
Sbjct: 448 LKENE--RITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD-PTRVMVPP 504
Query: 221 LDSTVIDGMSVVLACETSGAPRPAI--TWQKGERILA--SGSVQLPRFTPLES-GSLLIS 275
V G S+VL C+ + I TW ++ R +S G L+I
Sbjct: 505 SSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIR 564
Query: 276 PTHISDAGTYTCLATNSRGVDEASADLVV 304
+ AG Y C+ S A+ADL+V
Sbjct: 565 NIQLKHAGKYVCMVQTSVDRLSAAADLIV 593
Score = 59.7 bits (143), Expect = 5e-09
Identities = 77/324 (23%), Positives = 113/324 (34%), Gaps = 59/324 (18%)
Query: 58 KLHIIWKKDGVLLSGGI----SDHNRRLTIPNPTGS-DAGYYECEAVLRSSSVPSVVRGA 112
K HI WK +G + G+ S L I NP + DAG Y+C A ++ S R A
Sbjct: 57 KPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVS--REA 114
Query: 113 YLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPP-----SITWYKDAAVVEVEKLT 167
L F ++ + + + C PPP S W + +
Sbjct: 115 KLQFAYLDNFKTRTRSTVSVRRGQGMVLLCG----PPPHSGELSYAWIFNE-YPSYQDNR 169
Query: 168 RFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG-------- 219
RF + G L I+ + D G + C N + + + P I R
Sbjct: 170 RFVSQETGNLYIAKVEKSDVGNYTCVVTNTV-----TNHKVLGPPTPLILRNDGVMGEYE 224
Query: 220 -------PLDSTVIDGMSVVLACETSGAPRPAITWQ---------KGERILASGSVQLPR 263
P G +V L C G P P I W+ K R ++G +++P
Sbjct: 225 PKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPN 284
Query: 264 FTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGT 323
F DAG Y C+A NSRG + A L +A+ + D V
Sbjct: 285 FQQ-------------EDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEE 331
Query: 324 QASMVCGVTHDPRVTIRQLRPGAP 347
C P+ T + L+ G P
Sbjct: 332 NVFWECKANGRPKPTYKWLKNGEP 355
Score = 57.4 bits (137), Expect = 2e-08
Identities = 54/187 (28%), Positives = 76/187 (40%), Gaps = 17/187 (9%)
Query: 115 SVLEPPQFVKEPERHITA--EMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 172
S L P F++EP + EK V + C+ KG P P I W + V+ R+
Sbjct: 21 STLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVV 80
Query: 173 NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI-TRGPLDSTVIDGMSV 231
L + D G +QC A N+ G + + + N TR +V G +
Sbjct: 81 EGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGM 140
Query: 232 VLACETSGAPRPAITWQKGERILASGSVQLP------RFTPLESGSLLISPTHISDAGTY 285
VL C P P GE A + P RF E+G+L I+ SD G Y
Sbjct: 141 VLLC----GPPP----HSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNY 192
Query: 286 TCLATNS 292
TC+ TN+
Sbjct: 193 TCVVTNT 199
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 132 bits (333), Expect = 4e-31
Identities = 99/286 (34%), Positives = 138/286 (48%), Gaps = 20/286 (6%)
Query: 61 IIWKK-DGVLLSGGIS--DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL 117
I W++ DG+ S I + L IPN DAG YEC + +S +V RG
Sbjct: 259 INWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYEC--IAENSRGKNVARGRLTYYA 316
Query: 118 EPP--QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG 175
+P Q +K+ E +E + C+A G P PS W K+ A + +E+ T Q +G
Sbjct: 317 KPHWVQLIKDVE----IAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERT---QIENG 369
Query: 176 GLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID--GMSVVL 233
L IS L D+GMFQC A N G V +S L V + AP+ ++ P+ V G V L
Sbjct: 370 ALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSL 429
Query: 234 ACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSR 293
C+ +PR +W+KG+ + R + L G L I+ +DAGTYTC+A N
Sbjct: 430 DCKPRASPRALSSWKKGDVSVQEHE----RISLLNDGGLKIANVTKADAGTYTCMAENQF 485
Query: 294 GVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTI 339
G + LVV TRIT P + V G + C V HDP + I
Sbjct: 486 GKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDI 531
Score = 90.9 bits (224), Expect = 2e-18
Identities = 79/271 (29%), Positives = 123/271 (45%), Gaps = 24/271 (8%)
Query: 45 WKIRPQGPTRPLIKLHIIWKKDG--VLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRS 102
W+ R G +P + W K+G ++L N LTI N + +D+G ++C A +
Sbjct: 337 WECRASGKPKPSYR----WLKNGAALVLEERTQIENGALTISNLSVTDSGMFQCIAENKH 392
Query: 103 SSVPSVVRGAYLSVL-EPPQFVKEP-ERHITAEMEKVVDIPCQAKGVPPPSITWYK-DAA 159
V S A L V+ P F K P ++ + ++ +V + C+ + P +W K D +
Sbjct: 393 GLVYS---SAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVS 449
Query: 160 VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG 219
V E E+++ NDGGL+I+ + D G + C A N G+ +T+L VT IT
Sbjct: 450 VQEHERISLL---NDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTE-PTRITLA 505
Query: 220 PLDSTVIDGMSVVLACETSGAPRPAI--TWQKGERI--LASGSVQLPRFTPLESGSLLIS 275
P + V G SV+L C+ P I TW + + SG L+I
Sbjct: 506 PSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIR 565
Query: 276 PTHISDAGTYTCLATNSRGVDEAS--ADLVV 304
+ +G Y C+ GVD S ADL+V
Sbjct: 566 NIQLKHSGKYVCMV--QTGVDSVSSAADLIV 594
Score = 68.2 bits (165), Expect = 1e-11
Identities = 73/283 (25%), Positives = 113/283 (39%), Gaps = 27/283 (9%)
Query: 81 LTIPNPTGS-DAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVD 139
L + NP + D G Y+C A ++ S R A L F + ++ + V
Sbjct: 84 LVVINPNRNWDTGTYQCFATNSLGTIVS--REAKLQFAYLENFKTKMRSTVSVREGQGVV 141
Query: 140 IPCQAKGVPPP-----SITW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCF 193
+ C PPP S W + + E RF + G L IS + P D G + C
Sbjct: 142 LLCG----PPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCV 197
Query: 194 ARNAAGEVQ---TSTYLAVTS------IAPNI-TRGPLDSTVIDGMSVVLACETSGAPRP 243
+ + + T L + S P I + P G +V L C G P P
Sbjct: 198 VTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIP 257
Query: 244 AITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLV 303
I W++ + + S ++L +F SG L I DAG+Y C+A NSRG + A L
Sbjct: 258 QINWRRSDGLPFSSKIKLRKF----SGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLT 313
Query: 304 VWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGA 346
+A+ + +D + C + P+ + R L+ GA
Sbjct: 314 YYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGA 356
Score = 67.4 bits (163), Expect = 2e-11
Identities = 51/182 (28%), Positives = 82/182 (45%), Gaps = 9/182 (4%)
Query: 116 VLEPPQFVKEPERHI--TAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN 173
+L+ P F+KEP I +K + + C+A+G P P W + + +++ R++
Sbjct: 22 LLQGPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNG 81
Query: 174 DGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI-TRGPLDSTVIDGMSVV 232
+ I+ DTG +QCFA N+ G + + + N T+ +V +G VV
Sbjct: 82 GNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVV 141
Query: 233 LAC---ETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 289
L C SG A + + + S RF E+G L IS SD G YTC+
Sbjct: 142 LLCGPPPHSGELSYAWIFNEYPSFVEEDS---RRFVSQETGHLYISKVEPSDVGNYTCVV 198
Query: 290 TN 291
T+
Sbjct: 199 TS 200
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 128 bits (322), Expect = 8e-30
Identities = 97/294 (32%), Positives = 131/294 (44%), Gaps = 23/294 (7%)
Query: 69 LLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPER 128
+LSGG R L I N D Y C A S+ R L+V PP +K +
Sbjct: 3670 ILSGG-----RYLQINNADLGDTANYTCVA---SNIAGKTTREFILTVNVPPN-IKGGPQ 3720
Query: 129 HITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTG 188
+ + K + C A+GVP P ITW KD AV+ R+ +G L I DTG
Sbjct: 3721 SLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNH-ARYSILENGFLHIQSAHVTDTG 3779
Query: 189 MFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQ 248
+ C A NAAG + L V + P+I GP + TVI + LACE +G P+P+I W+
Sbjct: 3780 RYLCMATNAAGTDRRRIDLQV-HVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWR 3838
Query: 249 KGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWART 308
K +L Q + L SGSL+I + D TY C TN G D+ + DL V
Sbjct: 3839 KNGHLLNVDQNQ-NSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPP 3897
Query: 309 RITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGGHWTYDSLYSHPQ 362
I P D V K A + C + P +I HWT + + P+
Sbjct: 3898 SIADEPTDFLVTKHAPAVITCTASGVPFPSI-----------HWTKNGIRLLPR 3940
Score = 128 bits (321), Expect = 1e-29
Identities = 93/295 (31%), Positives = 128/295 (43%), Gaps = 27/295 (9%)
Query: 63 WKKDG---------VLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY 113
W KDG L GG L I D G Y C L SS +
Sbjct: 3562 WMKDGRPLPQTDQVQTLGGG-----EVLRISTAQVEDTGRYTC---LASSPAGDDDKEYL 3613
Query: 114 LSVLEPPQFVKEPE-RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 172
+ V PP E R IT + V + C++ VPPP ITW ++ ++ R
Sbjct: 3614 VRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILS- 3672
Query: 173 NDGG--LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMS 230
GG LQI+ DT + C A N AG+ T ++ ++ PNI GP ++ S
Sbjct: 3673 --GGRYLQINNADLGDTANYTCVASNIAGKT-TREFILTVNVPPNIKGGPQSLVILLNKS 3729
Query: 231 VVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLAT 290
VL C G P P ITW+K +LA R++ LE+G L I H++D G Y C+AT
Sbjct: 3730 TVLECIAEGVPTPRITWRKDGAVLAGNHA---RYSILENGFLHIQSAHVTDTGRYLCMAT 3786
Query: 291 NSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPG 345
N+ G D DL V I P + +VI Q ++ C T P+ +I + G
Sbjct: 3787 NAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNG 3841
Score = 113 bits (283), Expect = 3e-25
Identities = 96/306 (31%), Positives = 143/306 (46%), Gaps = 35/306 (11%)
Query: 61 IIWKKDGV----------LLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVR 110
+ W KDG +LSGG R L + + SD G Y C AV ++ R
Sbjct: 2043 LTWLKDGSPVSSFSNGLQVLSGG-----RILALTSAQISDTGRYTCVAV---NAAGEKQR 2094
Query: 111 GAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFR 170
L V PP + E E++++ + + V++ CQ+ +PPP++TW KD + ++K
Sbjct: 2095 DIDLRVYVPPNIMGE-EQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPL-LKKPGLSI 2152
Query: 171 QRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS----TVI 226
N L+I DTG + C A N AG+ + + Y + PNI G D TVI
Sbjct: 2153 SENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKN-YNVNIWVPPNI--GGSDELTQLTVI 2209
Query: 227 DGMSVVLACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESG-SLLISPTHISDAGT 284
+G + L CE+SG P P + W +KG +L + R L G L IS SDA
Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTD---SMGRVRILSGGRQLQISIAEKSDAAL 2266
Query: 285 YTCLATNSRGVDEASADLVVWARTRITKP---PQDQSVIKGTQASMVCGVTHDPRVTIRQ 341
Y+C+A+N G + +L V+ R IT P + V +G S+ C V P T+
Sbjct: 2267 YSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTW 2326
Query: 342 LRPGAP 347
++ G P
Sbjct: 2327 MKDGHP 2332
Score = 113 bits (282), Expect = 3e-25
Identities = 103/330 (31%), Positives = 143/330 (43%), Gaps = 27/330 (8%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I+W KDG L+ I + R+L I S+ G Y C A +++ + ++V
Sbjct: 1766 IMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMA---ANTAGDHKKEFEVTV 1822
Query: 117 LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
PP K V + C A G+P PSITW KD V + Q +
Sbjct: 1823 HVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRV 1882
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGP-LDSTVIDGMSVVLAC 235
LQI+ + +D G + C A NAAGE Q L V G L+ TV+ V L C
Sbjct: 1883 LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC 1942
Query: 236 ETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSRG 294
+ +G P P ITW K R+L SGS + T L G ++ I ISDAG Y C+A NS G
Sbjct: 1943 KAAGNPVPVITWYKDNRLL-SGSTSM---TFLNRGQIIDIESAQISDAGIYKCVAINSAG 1998
Query: 295 VDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGGHWTY 354
E L V I+ +V+ + C P ++ L+ G+P
Sbjct: 1999 ATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPV------ 2052
Query: 355 DSLYSHPQMRLRGAQVGTRGSRLLANTDSQ 384
S +S+ G QV G R+LA T +Q
Sbjct: 2053 -SSFSN------GLQV-LSGGRILALTSAQ 2074
Score = 113 bits (282), Expect = 3e-25
Identities = 102/340 (30%), Positives = 146/340 (42%), Gaps = 27/340 (7%)
Query: 63 WKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE 118
W +DG L +S H L + D+G Y C A S+ V + L VLE
Sbjct: 3469 WLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIA---SNEAGEVSKHFILKVLE 3525
Query: 119 PPQFV-KEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG- 176
PP E I+ + +++ C A G+P P +TW KD + T Q GG
Sbjct: 3526 PPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQ---TDQVQTLGGGE 3582
Query: 177 -LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI--TRGPLDSTVIDGMSVVL 233
L+IS +DTG + C A + AG+ YL + PNI T P D TV+ V L
Sbjct: 3583 VLRISTAQVEDTGRYTCLASSPAGD-DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTL 3641
Query: 234 ACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATN 291
C++ P P ITW + GER+ A+ PR L G L I+ + D YTC+A+N
Sbjct: 3642 ECKSDAVPPPVITWLRNGERLQAT-----PRVRILSGGRYLQINNADLGDTANYTCVASN 3696
Query: 292 SRGVDEASADLVVWARTRITKPPQDQSVI--KGTQASMVCGVTHDPRVTIRQLRPGAPSG 349
G L V I PQ ++ K T + PR+T R + GA
Sbjct: 3697 IAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWR--KDGAVLA 3754
Query: 350 GHWTYDSLYSHPQMRLRGAQVGTRGSRLLANTDSQRTYQR 389
G+ S+ + + ++ A V G L T++ T +R
Sbjct: 3755 GNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRR 3794
Score = 112 bits (281), Expect = 5e-25
Identities = 87/291 (29%), Positives = 131/291 (45%), Gaps = 15/291 (5%)
Query: 61 IIWKKDGVLLSGGISDH----NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I W+KDG +L+G + + N L I + +D G Y C A +++ + R L V
Sbjct: 3744 ITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMA---TNAAGTDRRRIDLQV 3800
Query: 117 LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEK-LTRFRQRNDG 175
PP P ++T + + C+A G+P PSI W K+ ++ V++ +R + G
Sbjct: 3801 HVPPSIAPGPT-NMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSG 3859
Query: 176 GLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLAC 235
L I DDT ++C N AG+ + + L V + P+I P D V V+ C
Sbjct: 3860 SLVIISPSVDDTATYECTVTNGAGDDKRTVDLTV-QVPPSIADEPTDFLVTKHAPAVITC 3918
Query: 236 ETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRG 294
SG P P+I W K G R+L G + L SG++ I T ++ AG YTC+A N+ G
Sbjct: 3919 TASGVPFPSIHWTKNGIRLLPRGD----GYRILSSGAIEILATQLNHAGRYTCVARNAAG 3974
Query: 295 VDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPG 345
L V I P + VI + C T P I + G
Sbjct: 3975 SAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEG 4025
Score = 111 bits (278), Expect = 1e-24
Identities = 87/299 (29%), Positives = 139/299 (46%), Gaps = 19/299 (6%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I W K+G +++ I + L I SD G Y C A+ + + +L+V
Sbjct: 3091 ITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDD---KNFHLNV 3147
Query: 117 LEPPQFVKEPERHITAE-MEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG 175
PP ++ PER + E + V + C A G+PPP+I W K+ +E R + G
Sbjct: 3148 YVPPS-IEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGG 3206
Query: 176 G-LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG--PLDSTVIDGMSVV 232
LQI+ D+G + C A N G+ Q +L++ + P++ P D +V+ G +V
Sbjct: 3207 SKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSI-QVPPSVAGAEIPSDVSVLLGENVE 3265
Query: 233 LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 292
L C +G P P I W K + +ASG + R + +L I SD G YTC+ATN
Sbjct: 3266 LVCNANGIPTPLIQWLKDGKPIASGETERIRVS-ANGSTLNIYGALTSDTGKYTCVATNP 3324
Query: 293 RGVDEASADLVVWARTRITKPPQDQS----VIKGTQASMVCGVTHDPRVTIRQLRPGAP 347
G ++ +L V+ T + +D++ + T ++ C T P I L+ G P
Sbjct: 3325 AGEEDRIFNLNVYV-TPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLP 3382
Score = 108 bits (271), Expect = 7e-24
Identities = 78/264 (29%), Positives = 120/264 (45%), Gaps = 13/264 (4%)
Query: 81 LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDI 140
L I DAG Y C A+ + + L V PP F++EP ++ E+ V +
Sbjct: 757 LKIQETQDLDAGDYTCVAINEAGRATGKIT---LDVGSPPVFIQEPA-DVSMEIGSNVTL 812
Query: 141 PCQAKGVPPPSITWYKDAAVVEVEK---LTRFRQRNDGGLQISGLVPDDTGMFQCFARNA 197
PC +G P P+I W + + + ++ Q G L I L D G + C A N
Sbjct: 813 PCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQ 872
Query: 198 AGEVQTSTYLAVTS-IAPNITRGPLDSTVIDGMSVVLACET-SGAPRPAITWQKGERILA 255
G++Q+ T + VT +AP I P + VI+G + L C +G P P W K +L
Sbjct: 873 FGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAML- 931
Query: 256 SGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQ 315
+Q P T GSL I + D G YTC+A+N G + + +VV I Q
Sbjct: 932 ---LQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQ 988
Query: 316 DQSVIKGTQASMVCGVTHDPRVTI 339
S I+G ++ C + +P+ ++
Sbjct: 989 ILSTIEGIPVTLPCKASGNPKPSV 1012
Score = 108 bits (270), Expect = 9e-24
Identities = 91/292 (31%), Positives = 136/292 (46%), Gaps = 27/292 (9%)
Query: 69 LLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFV-KEPE 127
+LSGG +L I SD+G Y C A S+ + +LS+ PP E
Sbjct: 3202 ILSGG-----SKLQIARSQHSDSGNYTCIA---SNMEGKAQKYYFLSIQVPPSVAGAEIP 3253
Query: 128 RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG-LQISGLVPDD 186
++ + + V++ C A G+P P I W KD + + R R +G L I G + D
Sbjct: 3254 SDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSD 3313
Query: 187 TGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS-----TVIDGMSVVLACETSGAP 241
TG + C A N AGE L V + P I RG D T++D S+ + C +G P
Sbjct: 3314 TGKYTCVATNPAGEEDRIFNLNVY-VTPTI-RGNKDEAEKLMTLVD-TSINIECRATGTP 3370
Query: 242 RPAITWQK-GERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSRGVDEAS 299
P I W K G + S ++L L +G ++ I +SD YTC+A+N GVD
Sbjct: 3371 PPQINWLKNGLPLPLSSHIRL-----LAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKH 3425
Query: 300 ADLVVWARTRI--TKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSG 349
+L V+A + + ++ +V+KG+ SM C P ++ LR G P G
Sbjct: 3426 YNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLG 3477
Score = 108 bits (269), Expect = 1e-23
Identities = 81/240 (33%), Positives = 107/240 (44%), Gaps = 12/240 (5%)
Query: 91 AGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEP-ERHITAEMEKVVDIPCQAKGVPP 149
AG Y C A ++ S R L V EPP +P E H+ + + +PC+A G P
Sbjct: 3962 AGRYTCVA---RNAAGSAHRHVTLHVHEPPVIQPQPSELHVI--LNNPILLPCEATGTPS 4016
Query: 150 PSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAV 209
P ITW K+ V GGLQIS V +D G + C A+N AG L V
Sbjct: 4017 PFITWQKEGINVNTSGRNH-AVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNV 4075
Query: 210 TSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLES 269
+ P I+ + + + L+CE G P P ITW K R + V+ R L S
Sbjct: 4076 -QVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAI----VESIRQRVLSS 4130
Query: 270 GSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVC 329
GSL I+ DAG YTC+A N G S L V RI +V + +QA + C
Sbjct: 4131 GSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPC 4190
Score = 106 bits (265), Expect = 3e-23
Identities = 88/291 (30%), Positives = 129/291 (44%), Gaps = 19/291 (6%)
Query: 61 IIWKKDGVLLSGGISDH---NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL 117
I W KDG + I + L I DAG+Y C A + S + + L+V
Sbjct: 4110 ITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTK---LTVH 4166
Query: 118 EPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGL 177
PP+ ++ E H T +PC A G+P P+I W KD V+ L ++ G L
Sbjct: 4167 VPPR-IRSTEGHYTVNENSQAILPCVADGIPTPAINWKKD-NVLLANLLGKYTAEPYGEL 4224
Query: 178 QISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACET 237
+ +V +D+G + C A NAAGE T T + P T P D ++ G + L+C+
Sbjct: 4225 ILENVVLEDSGFYTCVANNAAGE-DTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKA 4283
Query: 238 SGAPRPAITWQKGERILASGSVQLPRFTPLESGS-LLISPTHISDAGTYTCLATNSRGVD 296
+G P P +TW I+ + F + S L+I D+GTY C A NS G
Sbjct: 4284 TGIPLPKLTWTFNNNIIPA------HFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFV 4337
Query: 297 EASADLVVWARTRITKPPQDQSVIK--GTQASMVCGVTHDPRVTIRQLRPG 345
+A + V + K + I+ G A + C V DP TI+ R G
Sbjct: 4338 KAIGFVYV-KEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKG 4387
Score = 105 bits (263), Expect = 6e-23
Identities = 88/293 (30%), Positives = 134/293 (45%), Gaps = 23/293 (7%)
Query: 61 IIWKKDGVLLSGGISDHNRR----LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I WKKD VLL+ + + L + N D+G+Y C A +++ L+V
Sbjct: 4200 INWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVA---NNAAGEDTHTVSLTV 4256
Query: 117 LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
P F + P ++ + + + C+A G+P P +TW + ++ F N
Sbjct: 4257 HVLPTFTELPG-DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAH----FDSVNGHS 4311
Query: 177 -LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID--GMSVVL 233
L I + +D+G + C A N+ G V+ ++ V P + +G S I+ G + +L
Sbjct: 4312 ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKE--PPVFKGDYPSNWIEPLGGNAIL 4369
Query: 234 ACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 292
CE G P P I W +KG I S R L +GSL I T DAG YTC+ATN
Sbjct: 4370 NCEVKGDPTPTIQWNRKGVDIEISH-----RIRQLGNGSLAIYGTVNEDAGDYTCVATNE 4424
Query: 293 RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPG 345
GV E S L + + IT P + + G + + C T +P+ TI R G
Sbjct: 4425 AGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQG 4477
Score = 105 bits (261), Expect = 9e-23
Identities = 88/269 (32%), Positives = 120/269 (44%), Gaps = 16/269 (5%)
Query: 78 NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERH-ITAEMEK 136
N L + + +DAG Y C + SS S +L+V EPP+ P+ T E
Sbjct: 573 NLSLELKSVKFNDAGEYHC---MVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSE- 628
Query: 137 VVDIPCQAKGVPPPSITW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFAR 195
V I C A G P P I W D +V R+R +DG L I P D G++ C A
Sbjct: 629 -VSIMCSATGYPKPKIAWTVNDMFIVGSH---RYRMTSDGTLFIKNAAPKDAGIYGCLAS 684
Query: 196 NAAG-EVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERIL 254
N+AG + Q ST + AP + + V G V+ C+TSG P P + W KG+ L
Sbjct: 685 NSAGTDKQNSTLRYIE--APKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLEL 742
Query: 255 ASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPP 314
+ + PL G L I T DAG YTC+A N G L V + + P
Sbjct: 743 RPSTFLI--IDPL-LGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEP 799
Query: 315 QDQSVIKGTQASMVCGVTHDPRVTIRQLR 343
D S+ G+ ++ C V P TI+ R
Sbjct: 800 ADVSMEIGSNVTLPCYVQGYPEPTIKWRR 828
Score = 103 bits (258), Expect = 2e-22
Identities = 87/294 (29%), Positives = 126/294 (42%), Gaps = 15/294 (5%)
Query: 61 IIWKKDGVLLSGG-----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLS 115
I W KD ++ I R L I DAG Y C A + ++ L
Sbjct: 1858 ITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQ---LH 1914
Query: 116 VLEPPQFVKEPER-HITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 174
V EPP + + T + V + C+A G P P ITWYKD ++ F R
Sbjct: 1915 VHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQ 1974
Query: 175 GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLA 234
+ I D G+++C A N+AG + L V +AP+I+ V+ V L
Sbjct: 1975 I-IDIESAQISDAGIYKCVAINSAGATELFYSLQV-HVAPSISGSNNMVAVVVNNPVRLE 2032
Query: 235 CETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSR 293
CE G P P++TW K ++S S L L G +L ++ ISD G YTC+A N+
Sbjct: 2033 CEARGIPAPSLTWLKDGSPVSSFSNGLQ---VLSGGRILALTSAQISDTGRYTCVAVNAA 2089
Query: 294 GVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAP 347
G + DL V+ I Q+ SV+ ++C P T+ L+ G P
Sbjct: 2090 GEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHP 2143
Score = 103 bits (258), Expect = 2e-22
Identities = 94/309 (30%), Positives = 134/309 (43%), Gaps = 37/309 (11%)
Query: 60 HIIWKKDGV-----------LLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSV 108
++IWKK G +LSGG R+L I SDA Y C A S+V
Sbjct: 2227 NLIWKKKGSPVLTDSMGRVRILSGG-----RQLQISIAEKSDAALYSCVA----SNVAGT 2277
Query: 109 VRGAY-LSVLEPPQFVKEPER--HITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEK 165
+ Y L V P I K + + C+ +G+PPP++TW KD + K
Sbjct: 2278 AKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAK 2337
Query: 166 LTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNIT---RGPLD 222
LQ+ + DTG + C A N AG L+V + P+I R P +
Sbjct: 2338 GVEILDEGHI-LQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHA-PPSIIGNHRSPEN 2395
Query: 223 STVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLL-ISPTHIS 280
+V++ SV L CE SG P P+ITW K G + S SV++ L G +L + T +
Sbjct: 2396 ISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRI-----LSGGRMLRLMQTTME 2450
Query: 281 DAGTYTCLATNSRGVDEASADLVVWARTRIT--KPPQDQSVIKGTQASMVCGVTHDPRVT 338
DAG YTC+ N+ G + L V I +D V + ++ C VT +P
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPE 2510
Query: 339 IRQLRPGAP 347
I + G P
Sbjct: 2511 ITWHKDGQP 2519
Score = 101 bits (251), Expect = 1e-21
Identities = 85/303 (28%), Positives = 133/303 (43%), Gaps = 29/303 (9%)
Query: 61 IIWKKDGVLLSGGIS----DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I+W KD V ++ + ++ + L + T DAG Y C+A+ + + + V
Sbjct: 1392 IMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFN---IDV 1448
Query: 117 LEPPQFVKEP-ERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVV-----EVEKLTRFR 170
L PP + ++ + + V + CQ KG P P I W+KD + VE L R +
Sbjct: 1449 LVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQ 1508
Query: 171 QRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPL--DSTVIDG 228
L + +D G +QC NAAG+ L + I P+I G + D +V+
Sbjct: 1509 V-----LHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIY-IPPSIKGGNVTTDISVLIN 1562
Query: 229 MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISP-THISDAGTYTC 287
+ L CET G P PAITW K + + S S L ++ G L P +SD+ TYTC
Sbjct: 1563 SLIKLECETRGLPMPAITWYKDGQPIMSSSQAL----YIDKGQYLHIPRAQVSDSATYTC 1618
Query: 288 LATNSRGVDEASADLVVWARTRI---TKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRP 344
N G E S + V+ I P ++ V+ ++ C +P + L+
Sbjct: 1619 HVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKD 1678
Query: 345 GAP 347
G P
Sbjct: 1679 GVP 1681
Score = 100 bits (249), Expect = 2e-21
Identities = 67/217 (30%), Positives = 101/217 (46%), Gaps = 13/217 (5%)
Query: 138 VDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNA 197
V +PC+A G P PS+ W K ++ +F DG L + +++G + C A N
Sbjct: 998 VTLPCKASGNPKPSVIWSKKGELISTSS-AKFSAGADGSLYVVSPGGEESGEYVCTATNT 1056
Query: 198 AGEVQTSTYLAVTSIAPNI---TRG-----PLDSTVIDGMSVVLACETSGAPRPAITWQK 249
AG + L V + P + RG P++ +V+ G V L CE P P ITW K
Sbjct: 1057 AGYAKRKVQLTVY-VRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAK 1115
Query: 250 GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTR 309
++++ S PR T L SGS+ I+ T SD+G Y C+ATN G + L V +
Sbjct: 1116 ETQLISPFS---PRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPK 1172
Query: 310 ITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGA 346
I + P+ V G + + C P I + G+
Sbjct: 1173 IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGS 1209
Score = 99.8 bits (247), Expect = 4e-21
Identities = 85/287 (29%), Positives = 124/287 (43%), Gaps = 21/287 (7%)
Query: 61 IIWKKDGVLLSGGISDH----NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I W K+ L+S H + + I SD+G Y C A + +V V+ L+V
Sbjct: 1111 ITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVK---LNV 1167
Query: 117 LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
PP+ + P +H+ ++ + VDIPC A+G P P ITW K + + V+ DG
Sbjct: 1168 HVPPKIQRGP-KHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDG-EHHVSNPDGT 1225
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI--TRGPLDSTV---IDGMSV 231
L I P D G++ C A N AG +T L V P + P ++T + +
Sbjct: 1226 LSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE-PPTVEDLEPPYNTTFQERVANQRI 1284
Query: 232 VLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLAT 290
C G P+P I W R L + P + LE G+LL I+ D G Y C+A
Sbjct: 1285 EFPCPAKGTPKPTIKWLHNGRELTG---REPGISILEDGTLLVIASVTPYDNGEYICVAV 1341
Query: 291 NSRGVDEASADLVVWARTRITKPPQ--DQSVIKGTQASMVCGVTHDP 335
N G E +L V I Q + SV+ ++ C V P
Sbjct: 1342 NEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTP 1388
Score = 99.8 bits (247), Expect = 4e-21
Identities = 89/296 (30%), Positives = 129/296 (43%), Gaps = 29/296 (9%)
Query: 63 WKKDGVLLSGGISDHN------RRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
W+KDG L DH+ R L I N +D G Y C A ++ S + L+V
Sbjct: 2906 WQKDGQPLLE--DDHHKFLSNGRILQILNTQITDIGRYVCVA---ENTAGSAKKYFNLNV 2960
Query: 117 LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
PP + ++T + + + C+ G PPP ++W K+ +++ T GG
Sbjct: 2961 HVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLI---VPGG 3017
Query: 177 --LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS----TVIDGMS 230
LQI D G + C A N AGE + L V + P+I +S V +G S
Sbjct: 3018 RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV-YVPPSIKDHDSESLSVVNVREGTS 3076
Query: 231 VVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCL 288
V L CE++ P P ITW K G I S V++ L G +L I +SD G Y C
Sbjct: 3077 VSLECESNAVPPPVITWYKNGRMITESTHVEI-----LADGQMLHIKKAEVSDTGQYVCR 3131
Query: 289 ATNSRGVDEASADLVVWARTRITKPPQDQSV-IKGTQASMVCGVTHDPRVTIRQLR 343
A N G D+ + L V+ I P ++ V ++ C T P TI L+
Sbjct: 3132 AINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLK 3187
Score = 95.9 bits (237), Expect = 6e-20
Identities = 71/264 (26%), Positives = 114/264 (43%), Gaps = 17/264 (6%)
Query: 81 LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDI 140
L I N SD G Y CEA + + S ++ P + ++ + + +
Sbjct: 852 LFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQ--LTL 909
Query: 141 PCQA-KGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAG 199
PC G P P W K++A++ R +DG L I + D G + C A N AG
Sbjct: 910 PCTLLAGNPIPERRWIKNSAMLLQNPYITVR--SDGSLHIERVQLQDGGEYTCVASNVAG 967
Query: 200 EVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSV 259
T V + P I G + I+G+ V L C+ SG P+P++ W K ++++ S
Sbjct: 968 -TNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSA 1026
Query: 260 QLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRI--------T 311
+F+ GSL + ++G Y C ATN+ G + L V+ R R+
Sbjct: 1027 ---KFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQ 1083
Query: 312 KPPQDQSVIKGTQASMVCGVTHDP 335
P + SV+ G + ++ C V P
Sbjct: 1084 DKPVEISVLAGEEVTLPCEVKSLP 1107
Score = 92.0 bits (227), Expect = 8e-19
Identities = 69/270 (25%), Positives = 111/270 (41%), Gaps = 15/270 (5%)
Query: 81 LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDI 140
L I T SD G+YEC AV SS + + V EPP ++ P E+ V +
Sbjct: 484 LDIAKVTLSDEGFYECIAV---SSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAV-L 539
Query: 141 PCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGE 200
C ++TW ++ V + + R R + L++ + +D G + C + G
Sbjct: 540 TCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGS 599
Query: 201 VQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQ 260
S +L V P +T P + + G V + C +G P+P I W + +
Sbjct: 600 SAASVFLTVQE-PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSH-- 656
Query: 261 LPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVI 320
R+ G+L I DAG Y CLA+NS G D+ ++ L ++ + V
Sbjct: 657 --RYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVA 714
Query: 321 KGTQASMVCGVTHDPRVTIR------QLRP 344
G M C + P ++ +LRP
Sbjct: 715 LGDITVMECKTSGIPPPQVKWFKGDLELRP 744
Score = 90.1 bits (222), Expect = 3e-18
Identities = 83/332 (25%), Positives = 140/332 (42%), Gaps = 35/332 (10%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY-LS 115
+ W KDGV + I ++L I + D G Y C A +SV Y +
Sbjct: 1673 LTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVA----TSVAGEKEIKYEVD 1728
Query: 116 VLEPPQFVKEPER-HITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 174
VL PP E + + ++++ C G PPP+I W KD +++ + N
Sbjct: 1729 VLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKI-LLNG 1787
Query: 175 GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI-TRGPLDSTVIDGMSVVL 233
L I+ +TG+++C A N AG+ + + P I + G + V+ V L
Sbjct: 1788 RKLVIAQAQVSNTGLYRCMAANTAGD-HKKEFEVTVHVPPTIKSSGLSERVVVKYKPVAL 1846
Query: 234 ACETSGAPRPAITWQKGERIL--ASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLAT 290
C +G P P+ITW K ++ + A G++++ SG +L I+ T + DAG YTC+AT
Sbjct: 1847 QCIANGIPNPSITWLKDDQPVNTAQGNLKIQ-----SSGRVLQIAKTLLEDAGRYTCVAT 1901
Query: 291 NSRGVDEASADLVVWARTRITKPPQ--------DQSVIKGTQASMVCGVTHDPRVTIRQL 342
N+ G + L + +PP +++V+ + C +P I
Sbjct: 1902 NAAGETQQHIQL------HVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWY 1955
Query: 343 RPGAPSGGHWTYDSLYSHPQMRLRGAQVGTRG 374
+ G + L + + AQ+ G
Sbjct: 1956 KDNRLLSGSTSMTFLNRGQIIDIESAQISDAG 1987
Score = 89.0 bits (219), Expect = 7e-18
Identities = 87/310 (28%), Positives = 133/310 (42%), Gaps = 25/310 (8%)
Query: 50 QGPTRPLIKLHIIWKKDGVLLSG---GIS--DHNRRLTIPNPTGSDAGYYECEAVLRSSS 104
+G +P IK W +G L+G GIS + L I + T D G Y C AV + +
Sbjct: 1291 KGTPKPTIK----WLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGT 1346
Query: 105 VPSVVRGAYLSVLEPPQFV-KEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEV 163
R L V PP KE +++ + ++ ++ C+ +G P P I WYKD V+V
Sbjct: 1347 TE---RKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDN--VQV 1401
Query: 164 EKLTRFRQRNDGG-LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI--TRGP 220
+ + + N+G L++ P+D G + C A N AG Q + V + P I T P
Sbjct: 1402 TESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVL-VPPTIIGTNFP 1460
Query: 221 LDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHI 279
+ +V+ V L C+ G P P I W K + L G P L+ G +L +
Sbjct: 1461 NEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGD---PNVELLDRGQVLHLKNARR 1517
Query: 280 SDAGTYTCLATNSRGVDEASADLVVWARTRIT--KPPQDQSVIKGTQASMVCGVTHDPRV 337
+D G Y C +N+ G L ++ I D SV+ + + C P
Sbjct: 1518 NDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMP 1577
Query: 338 TIRQLRPGAP 347
I + G P
Sbjct: 1578 AITWYKDGQP 1587
Score = 85.1 bits (209), Expect = 1e-16
Identities = 81/279 (29%), Positives = 111/279 (39%), Gaps = 38/279 (13%)
Query: 61 IIWKKDGVLLSGGISDH----NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I W KDG L + H R L I N G Y C L SS R L+V
Sbjct: 2511 ITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTC---LASSPAGHKSRSFSLNV 2567
Query: 117 LEPPQFVK-----EPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQ 171
P PE +T + + C+A PP +ITW+KD +E + R
Sbjct: 2568 FVSPTIAGVGSDGNPE-DVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILP 2626
Query: 172 RNDGG--LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG--------PL 221
GG LQI D+ G + C A N AGE+ Y I P I +G P
Sbjct: 2627 ---GGRTLQILNAQEDNAGRYSCVATNEAGEM-IKHYEVKVYIPPIINKGDLWGPGLSPK 2682
Query: 222 DSTVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLLISPTHIS 280
+ + ++ L CE P +++W K G+ + + V + +L I IS
Sbjct: 2683 EVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA----NGHTLQIKEAQIS 2738
Query: 281 DAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSV 319
D G YTC+A+N G DE D+ I PP Q +
Sbjct: 2739 DTGRYTCVASNIAGEDELDFDV------NIQVPPSFQKL 2771
Score = 84.3 bits (207), Expect = 2e-16
Identities = 86/311 (27%), Positives = 133/311 (42%), Gaps = 40/311 (12%)
Query: 63 WKKDGVLLSG----GISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE 118
W KDG L I+ + L I SD G Y C A S+ +++
Sbjct: 2708 WYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVA---SNIAGEDELDFDVNIQV 2764
Query: 119 PPQFVK--------EPERHITAE---MEKVVDIPCQAKGVPPPSITWYKDA-AVVEVEKL 166
PP F K + R+ A+ + + + C+ PPP++TWYKD + +K+
Sbjct: 2765 PPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKV 2824
Query: 167 TRFRQRNDGG--LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG----- 219
GG LQI +D G + C A N AGE S V + P I +G
Sbjct: 2825 LIL----PGGRVLQIPRAKVEDAGRYTCVAVNEAGE--DSLQYDVRVLVPPIIKGANSDL 2878
Query: 220 PLDSTVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLL-ISPT 277
P + TV+ S ++ C +SG+P P +WQK G+ +L + L +G +L I T
Sbjct: 2879 PEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKF-----LSNGRILQILNT 2933
Query: 278 HISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQ-SVIKGTQASMVCGVTHDPR 336
I+D G Y C+A N+ G + +L V + P + +V+ S+ C V+ P
Sbjct: 2934 QITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPP 2993
Query: 337 VTIRQLRPGAP 347
+ L+ P
Sbjct: 2994 PDLSWLKNEQP 3004
Score = 81.6 bits (200), Expect = 1e-15
Identities = 89/336 (26%), Positives = 140/336 (41%), Gaps = 34/336 (10%)
Query: 61 IIWKKDG--VLLSGGIS--DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I W KDG V LS + R L + T DAG Y C V ++ + G LSV
Sbjct: 2418 ITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTC-VVRNAAGEERKIFG--LSV 2474
Query: 117 LEPPQFVKEPE-RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG 175
L PP V E + + ++ V + C+ G P P ITW+KD ++ ++ G
Sbjct: 2475 LVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHI---ISG 2531
Query: 176 G--LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNIT-----RGPLDSTVIDG 228
G LQI+ + TG + C A + AG S L V ++P I P D TVI
Sbjct: 2532 GRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV-FVSPTIAGVGSDGNPEDVTVILN 2590
Query: 229 MSVVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESG-SLLISPTHISDAGTYT 286
L CE P ITW K G + ++ ++++ L G +L I +AG Y+
Sbjct: 2591 SPTSLVCEAYSYPPATITWFKDGTPLESNRNIRI-----LPGGRTLQILNAQEDNAGRYS 2645
Query: 287 CLATNSRGVDEASADLVVWARTRITK--------PPQDQSVIKGTQASMVCGVTHDPRVT 338
C+ATN G ++ V+ I K P++ + ++ C P +
Sbjct: 2646 CVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSAS 2705
Query: 339 IRQLRPGAPSGGHWTYDSLYSHPQMRLRGAQVGTRG 374
+ + G P + + ++++ AQ+ G
Sbjct: 2706 LSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTG 2741
Score = 80.9 bits (198), Expect = 2e-15
Identities = 58/233 (24%), Positives = 105/233 (45%), Gaps = 16/233 (6%)
Query: 140 IPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAG 199
IPC + P ++++ ++ + V++ ++ L I+ + D G ++C A ++AG
Sbjct: 449 IPCSVDSLLPFTLSFVRNGVTLGVDQY--LKESASVNLDIAKVTLSDEGFYECIAVSSAG 506
Query: 200 EVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSV 259
+ T+ V+ P + + P + TV G VL C A +TWQ+ +R +
Sbjct: 507 TGRAQTFFDVSE-PPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLA-- 563
Query: 260 QLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSV 319
+ R L + SL + +DAG Y C+ ++ G AS L V ++T P++QS
Sbjct: 564 EPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSF 623
Query: 320 IKGTQASMVCGVTHDPRVTIRQLRPGAPSGGHWTYDSLYSHPQMRLRGAQVGT 372
G++ S++C T P+ I WT + ++ R R GT
Sbjct: 624 TGGSEVSIMCSATGYPKPKIA-----------WTVNDMFIVGSHRYRMTSDGT 665
Score = 76.6 bits (187), Expect = 4e-14
Identities = 79/315 (25%), Positives = 128/315 (40%), Gaps = 27/315 (8%)
Query: 47 IRPQGPTRPLIKLHIIWKKDGVLLSGGIS----DHNRRLTIPNPTGSDAGYYECEAVLRS 102
I+ + TR L I W KDG + D + L IP SD+ Y C +
Sbjct: 1565 IKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHV---A 1621
Query: 103 SSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIP------CQAKGVPPPSITWYK 156
+ + + ++ V PP E ++ + K V I C+A G P P +TW K
Sbjct: 1622 NVAGTAEKSFHVDVYVPPMI----EGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLK 1677
Query: 157 DAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI 216
D V+ R + L+I D G + C A + AGE + Y + P I
Sbjct: 1678 DGVPVKANDNIRI-EAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIK-YEVDVLVPPAI 1735
Query: 217 TRGPLDS--TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESG-SLL 273
G S V+ + L C +G+P P I W K +++ + F L +G L+
Sbjct: 1736 EGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLID----ERDGFKILLNGRKLV 1791
Query: 274 ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRI-TKPPQDQSVIKGTQASMVCGVT 332
I+ +S+ G Y C+A N+ G + ++ V I + ++ V+K ++ C
Sbjct: 1792 IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIAN 1851
Query: 333 HDPRVTIRQLRPGAP 347
P +I L+ P
Sbjct: 1852 GIPNPSITWLKDDQP 1866
Score = 55.8 bits (133), Expect = 7e-08
Identities = 38/124 (30%), Positives = 55/124 (44%), Gaps = 6/124 (4%)
Query: 78 NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKV 137
N L I DAG Y C A ++ V R L++ PP EP + K+
Sbjct: 4401 NGSLAIYGTVNEDAGDYTCVA---TNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKI 4457
Query: 138 VDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNA 197
+ + CQA G P P+ITW + + + R ++ L I+ +DT F+C ARN
Sbjct: 4458 I-LNCQATGEPQPTITWSRQGHSISWDD--RVNVLSNNSLYIADAQKEDTSEFECVARNL 4514
Query: 198 AGEV 201
G V
Sbjct: 4515 MGSV 4518
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 127 bits (318), Expect = 2e-29
Identities = 95/312 (30%), Positives = 142/312 (45%), Gaps = 24/312 (7%)
Query: 47 IRPQGPTRPLIKLHIIWKKDGVLLS---GGISDHNRRLTIPNPTGSDAGYYECEAVLRSS 103
+ P+G P + W+KDG L G I+ +L + + SDAG Y C A +
Sbjct: 188 VPPRGHPEPSVS----WRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAG 243
Query: 104 SVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEV 163
S A + VLE P F++ P + + V C+ KG PPP + W K+ +
Sbjct: 244 ERESAA--AEVMVLERPSFLRRPVNQVVLA-DAPVTFLCEVKGDPPPRLRWRKEDGELPT 300
Query: 164 EKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS 223
R+ R+D L I + +D G + C A N+ G + S L+V + P + P D
Sbjct: 301 G---RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV-HVPPQLVTQPQDQ 356
Query: 224 TVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQLP---RFTPLESGSLLISPTHI 279
G SV CET G P PAI WQK G ++L S L RF+ G L I+
Sbjct: 357 MAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQR 416
Query: 280 SDAGTYTCLATNSRGVDEASADLVVWARTR------ITKPPQDQSVIKGTQASMVCGVTH 333
DAG Y C A + G A A L + + I + P +Q+++ G+ + C VT
Sbjct: 417 GDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTG 476
Query: 334 DPRVTIRQLRPG 345
+P+ ++R + G
Sbjct: 477 NPQPSVRWKKDG 488
Score = 110 bits (274), Expect = 3e-24
Identities = 78/245 (31%), Positives = 118/245 (48%), Gaps = 23/245 (9%)
Query: 64 KKDGVLLSGGI---SDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPP 120
K+DG L +G SDH+ L I + + D G Y C A +SV LSV PP
Sbjct: 293 KEDGELPTGRYEIRSDHS--LWIGHVSAEDEGTYTCVA---ENSVGRAEASGSLSVHVPP 347
Query: 121 QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVV------EVEKLTRFRQRND 174
Q V +P+ + A E V C+ KG PPP+I W K+ + V ++ RF
Sbjct: 348 QLVTQPQDQMAAPGESVA-FQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPR 406
Query: 175 GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTS-----IAPNITRGPLDSTVIDGM 229
G L I+ + D G + C A + AG + L + + P I +GP + T++ G
Sbjct: 407 GQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGS 466
Query: 230 SVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 289
SV L C +G P+P++ W+K + L +Q F + +G+L I+ D G Y+C+A
Sbjct: 467 SVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQ---FKTMANGTLYIANVQEMDMGFYSCVA 523
Query: 290 TNSRG 294
+S G
Sbjct: 524 KSSTG 528
Score = 106 bits (265), Expect = 3e-23
Identities = 92/313 (29%), Positives = 133/313 (42%), Gaps = 27/313 (8%)
Query: 48 RPQGPTRPLIKLHIIWKKDGVLLSGGISDHN-RRLTIPNPT------------GSDAGYY 94
R +G RP I+ W K+G ++ D RL +P+ D G Y
Sbjct: 86 RAEGRPRPNIE----WYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVY 141
Query: 95 ECEAVLRSSSVPSVVRGAYLSV-LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSIT 153
C V R+ + R A L V + F + P + A E V +G P PS++
Sbjct: 142 TC--VARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVS 199
Query: 154 WYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIA 213
W KD A ++ E+ R R G L +S + D GM+ C A N AGE +++ +
Sbjct: 200 WRKDGARLKEEE-GRITIRG-GKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLER 257
Query: 214 PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL 273
P+ R P++ V+ V CE G P P + W+K + L +G R+ SL
Sbjct: 258 PSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTG-----RYEIRSDHSLW 312
Query: 274 ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTH 333
I D GTYTC+A NS G EAS L V ++ PQDQ G + C
Sbjct: 313 IGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKG 372
Query: 334 DPRVTIRQLRPGA 346
+P I + G+
Sbjct: 373 NPPPAIFWQKEGS 385
Score = 87.0 bits (214), Expect = 3e-17
Identities = 67/232 (28%), Positives = 108/232 (46%), Gaps = 16/232 (6%)
Query: 120 PQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR---NDGG 176
P+ V++P + + E +PC+A+G P P+I WYK+ A V + R G
Sbjct: 64 PRIVEQPPDLLVSRGEPAT-LPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGA 122
Query: 177 LQISGLV-----PDDTGMFQCFARNAAGEVQT-STYLAVTSIAPNITRGPLDSTVIDGMS 230
L +V D G++ C ARN G + + L V + + + P + V G
Sbjct: 123 LFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEP 182
Query: 231 VVLAC-ETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 289
VL C G P P+++W+K L ++ + G L++S T SDAG Y C+A
Sbjct: 183 AVLECVPPRGHPEPSVSWRKDGARLKEEEGRI----TIRGGKLMMSHTLKSDAGMYVCVA 238
Query: 290 TNSRGVDE-ASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIR 340
+N G E A+A+++V R + P +Q V+ + +C V DP +R
Sbjct: 239 SNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLR 290
Score = 65.1 bits (157), Expect = 1e-10
Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 18/162 (11%)
Query: 61 IIWKKDG--VLL--------SGGISDHNR-RLTIPNPTGSDAGYYECEAVLRSSSVPSV- 108
I W+K+G VLL +G S R +L I DAGYY C+AV + S+ +
Sbjct: 378 IFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKA 437
Query: 109 ---VRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEK 165
++GA L L PP ++ P T + V +PC+ G P PS+ W KD ++ +
Sbjct: 438 LLEIKGASLDGL-PPVILQGPANQ-TLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDD 495
Query: 166 LTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYL 207
L +F+ +G L I+ + D G + C A+++ GE S +L
Sbjct: 496 L-QFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWL 536
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 125 bits (313), Expect = 9e-29
Identities = 94/285 (32%), Positives = 138/285 (48%), Gaps = 18/285 (6%)
Query: 61 IIWKK-DGVLLSGGI--SDHNRRLTIPNPTGSDAGYYECEAV-LRSSSVPSVVRGAYLSV 116
I W++ DG L G + S L IPN D G+YEC A LR ++ +G +
Sbjct: 259 ISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNL---AKGQLIFY 315
Query: 117 LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
P K H++ + + C+A G P P TW K+ + E+ Q +G
Sbjct: 316 APPEWEQKIQNTHLSIYDNLLWE--CKASGKPNPWYTWLKNGERLNPEERI---QIENGT 370
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLD--STVIDGMSVVLA 234
L I+ L D+G++QC A N + + L V + AP+ ++ P+ S V G +V+
Sbjct: 371 LIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIG 430
Query: 235 CETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRG 294
C+ + PR AI+W++G L Q R LE GSL I SDAG+YTC+ATN G
Sbjct: 431 CKPNAFPRAAISWKRGTETLR----QSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFG 486
Query: 295 VDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTI 339
+ + L+V RT IT PP V G + C V+HDP + +
Sbjct: 487 TAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEV 531
Score = 71.6 bits (174), Expect = 1e-12
Identities = 68/243 (27%), Positives = 103/243 (42%), Gaps = 21/243 (8%)
Query: 74 ISDHNRRLTIPNPTGSDAGYYEC-------EAVLRSSSVPSVVR-GAYLSVLEPPQFVKE 125
+S L I SD G Y C + ++ P V R + EP V+
Sbjct: 174 VSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRF 233
Query: 126 PERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPD 185
PE I A + V + C A G P P I+W + K+ ++ L+I +
Sbjct: 234 PET-IQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVK--YSKSQAILEIPNFQQE 290
Query: 186 DTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL-ACETSGAPRPA 244
D G ++C A N G L AP + +T + +L C+ SG P P
Sbjct: 291 DEGFYECIASNLRGRNLAKGQLIF--YAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPW 348
Query: 245 ITWQK-GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLV 303
TW K GER+ +Q +E+G+L+I+ ++SD+G Y C A N + A+A+L
Sbjct: 349 YTWLKNGERLNPEERIQ------IENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELR 402
Query: 304 VWA 306
V A
Sbjct: 403 VLA 405
Score = 69.7 bits (169), Expect = 4e-12
Identities = 83/321 (25%), Positives = 123/321 (38%), Gaps = 25/321 (7%)
Query: 44 LWKIRPQGPTRPLIKLHIIWKKDGVLLSGG--ISDHNRRLTIPNPTGSDAGYYECEAVLR 101
LW+ + G P W K+G L+ I N L I SD+G Y+C A
Sbjct: 336 LWECKASGKPNPWYT----WLKNGERLNPEERIQIENGTLIITMLNVSDSGVYQCAA--- 388
Query: 102 SSSVPSVVRGAYLSVL-EPPQFVKEP-ERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA 159
+ + A L VL P F K P ++ ++ + I C+ P +I+W +
Sbjct: 389 ENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTE 448
Query: 160 VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG 219
+ K R DG L+I + D G + C A N G + + L V IT
Sbjct: 449 TLRQSK--RIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTV-ITVP 505
Query: 220 PLDSTVIDGMSVVLACETSGAPRPAITWQ---KGERI-LASGSVQLPRFTPLESGSLLIS 275
P V G S+VL C+ S P + + G+ I L G R G L+I
Sbjct: 506 PSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIR 565
Query: 276 PTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSV--IKGT--QASMVCGV 331
+ +G Y C + A AD++V PP+D V I T Q S G
Sbjct: 566 NIQLHHSGKYLCTVQTTLESLSAVADIIVRGP---PGPPEDVQVEDISSTTSQLSWRAGP 622
Query: 332 THDPRVTIRQLRPGAPSGGHW 352
++ + I ++ P W
Sbjct: 623 DNNSPIQIFTIQTRTPFSVGW 643
Score = 57.4 bits (137), Expect = 2e-08
Identities = 58/197 (29%), Positives = 83/197 (42%), Gaps = 17/197 (8%)
Query: 105 VPSVVRGAYLSVLEPPQFVKEPERHI-TAEMEKV-VDIPCQAKGVPPPSITWYKDAAVVE 162
+P + A +L P F +EP I ++ K V + C A G P P W ++ +
Sbjct: 11 LPLINSSAGDGLLSRPIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWKQNGT--D 68
Query: 163 VEKLTRFRQRNDGG-LQISGLVPD-DTGMFQCFARNAAGEVQT-STYLAVTSIAPNITRG 219
++ + R DGG L I+ D D GM+QC A N G + + L I T+
Sbjct: 69 IDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKT 128
Query: 220 PLDSTVIDGMSVVLACETSGAPRP-----AITWQKGERILASGSVQLPRFTPLESGSLLI 274
+V +G VVL C P P + W + L RF E+G+L I
Sbjct: 129 RSTVSVREGQGVVLLC----GPPPHFGDLSYAWTFNDNPLYVQEDNR-RFVSQETGNLYI 183
Query: 275 SPTHISDAGTYTCLATN 291
+ SD G YTC TN
Sbjct: 184 AKVEPSDVGNYTCFITN 200
Score = 38.1 bits (87), Expect = 0.014
Identities = 36/115 (31%), Positives = 48/115 (41%), Gaps = 11/115 (9%)
Query: 220 PLDSTVIDGMSVVLACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTH 278
PLD + V+L C +G P P W Q G I + S L+ GSL I+ H
Sbjct: 38 PLD---LSKSEVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYR----LDGGSLAINSPH 90
Query: 279 IS-DAGTYTCLATNSRG--VDEASADLVVWARTRITKPPQDQSVIKGTQASMVCG 330
D G Y CLATN G + + + TK SV +G ++CG
Sbjct: 91 TDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCG 145
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 122 bits (307), Expect = 4e-28
Identities = 90/288 (31%), Positives = 131/288 (45%), Gaps = 16/288 (5%)
Query: 50 QGPTRPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVV 109
QG +P +I W KDG L+ ++N R T DAG Y C L S ++
Sbjct: 2329 QGTPQP----NITWHKDGQALTR--LENNSRATRVLRV-RDAGLYTC---LAESPAGAIE 2378
Query: 110 RGAYLSVLEPPQFV-KEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTR 168
+ + V PP V R + + + C + P P ITW++D V++ + T+
Sbjct: 2379 KSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQ 2438
Query: 169 FRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDG 228
F +R LQ+ L D+G + C ARNAAG + + + ++ P I GP V
Sbjct: 2439 FPERGRF-LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV-PTIRSGPPAVNVSVN 2496
Query: 229 MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 288
+ +L C+ G P P ++W+K L S PRF L GSL I P DAG Y CL
Sbjct: 2497 QTALLPCQADGVPAPLVSWRKDRVPLDPRS---PRFEILPEGSLRIQPVLAQDAGHYLCL 2553
Query: 289 ATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPR 336
A+NS G D DL V I P + ++ T A + C + P+
Sbjct: 2554 ASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPK 2601
Score = 114 bits (285), Expect = 2e-25
Identities = 92/307 (29%), Positives = 132/307 (42%), Gaps = 22/307 (7%)
Query: 51 GPTRPLIKLHIIWKKDGVLLSGGISDHNRRLTIPN------PTGSDAGYYECEAVLRSSS 104
G +PL+ +W KDG L + RL N P D+ +EC S+
Sbjct: 2598 GSPKPLV----VWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVV---SNE 2650
Query: 105 VPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE 164
V R ++V PP + + + T M V + C + G+P P+++W K A +
Sbjct: 2651 VGEAHRLYQVTVHVPPT-IADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGAR 2709
Query: 165 KLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDST 224
+ +R G L+I +P G + C ARN+AG +L V + +P + P
Sbjct: 2710 G-SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQA-SPVVKPLPSVVR 2767
Query: 225 VIDGMSVVLACETSGAPRPAITWQKGERILASG-SVQLPRFTPLESGSLLISPTHISDAG 283
+ V+L CE SG PRP ITWQK +A+G S Q+ L G L I+ DAG
Sbjct: 2768 AVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV-----LPGGQLRIAHASPEDAG 2822
Query: 284 TYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLR 343
Y C+A NS G LVV I D S +G+ A + C P I +
Sbjct: 2823 NYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK 2882
Query: 344 PGAPSGG 350
G P G
Sbjct: 2883 DGQPVSG 2889
Score = 113 bits (283), Expect = 3e-25
Identities = 91/301 (30%), Positives = 124/301 (41%), Gaps = 25/301 (8%)
Query: 61 IIWKKDGV---------LLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRG 111
+ W KDG L GG +RL I SD G Y C+ S+ VR
Sbjct: 1873 VTWYKDGQPLVLAQRTQALRGG-----QRLEIQEAQVSDKGLYSCKV---SNVAGEAVRT 1924
Query: 112 AYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQ 171
L+V PP F ++ + + C GVP P++TW KD VE +
Sbjct: 1925 FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVS 1984
Query: 172 RNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPL--DSTVIDGM 229
R G LQ+S L P G + C A N E + +AV +AP I + + V++G
Sbjct: 1985 RG-GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVL-VAPRIRSSGVAREHHVLEGQ 2042
Query: 230 SVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 289
V L CE G P P + W K L RF L+ GSL++ SDAG YTC+A
Sbjct: 2043 EVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY-LDGGSLVLKGLRASDAGAYTCVA 2101
Query: 290 TNSRGVDEASADLVVWARTRITKPPQDQSVI---KGTQASMVCGVTHDPRVTIRQLRPGA 346
N G D + V I + + G +MVC V P + + L+ G
Sbjct: 2102 HNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGL 2161
Query: 347 P 347
P
Sbjct: 2162 P 2162
Score = 110 bits (274), Expect = 3e-24
Identities = 91/296 (30%), Positives = 133/296 (44%), Gaps = 23/296 (7%)
Query: 60 HIIWKKDGVLLSGGISDH----NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLS 115
+I W KDG +SG + L + N G DAG Y C A ++V R +L+
Sbjct: 2877 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTA---ENAVGRARRRVHLT 2933
Query: 116 VLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG 175
+L P F P + + + + C A+G P P I W V +T DG
Sbjct: 2934 ILVLPVFTTLPGDR-SLRLGDRLWLRCAARGSPTPRIGW-----TVNDRPVTEGVSEQDG 2987
Query: 176 G--LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID--GMSV 231
G LQ + + +D+G + C+A N G Q +++ V AP + +G S +++ G S+
Sbjct: 2988 GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE-AP-VLQGEAFSYLVEPVGGSI 3045
Query: 232 VLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATN 291
L C G P P I W K L ++ L++GSL I T DAG Y CLA N
Sbjct: 3046 QLDCVVRGDPVPDIHWIKDGLPLRGSHLR----HQLQNGSLTIHRTERDDAGRYQCLAEN 3101
Query: 292 SRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAP 347
GV + LV+ + PQD +V G ++ C T +P TI L+ G P
Sbjct: 3102 EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQP 3157
Score = 104 bits (259), Expect = 2e-22
Identities = 88/303 (29%), Positives = 128/303 (42%), Gaps = 27/303 (8%)
Query: 61 IIWKKDGVLLSGG------ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 114
I W+KDG L G +S R L + + G Y CE S+ V + + L
Sbjct: 1003 ISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCEC---SNVVGNSSQDLQL 1059
Query: 115 SVLEPPQFV--KEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 172
V PPQ +EP ++ + V + C A G PPP++TW +D V E L Q
Sbjct: 1060 EVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAE-LGLQLQN 1118
Query: 173 NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS----TVIDG 228
L + TG + C A N AG + L+V + P G LD T
Sbjct: 1119 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSV--LVPPELIGDLDPLTNITAALH 1176
Query: 229 MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGS--LLISPTHISDAGTYT 286
+ L CE G P PAI W +GE ++ G T L +G L ++ T D+G Y+
Sbjct: 1177 SPLTLLCEAMGIPPPAIRWFRGEEPVSPG-----EDTYLLAGGWMLKMTQTQEQDSGLYS 1231
Query: 287 CLATNSRGVDEASADLVVWARTRITKPPQDQ--SVIKGTQASMVCGVTHDPRVTIRQLRP 344
CLA+N G + + V I ++ V+ G A ++C VT P+ + +
Sbjct: 1232 CLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKD 1291
Query: 345 GAP 347
G P
Sbjct: 1292 GRP 1294
Score = 103 bits (258), Expect = 2e-22
Identities = 82/302 (27%), Positives = 135/302 (44%), Gaps = 25/302 (8%)
Query: 61 IIWKKDG----VLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
+ W++DG L + + + L + + G Y C A + R LSV
Sbjct: 1099 VTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVA---ENLAGRAERKFELSV 1155
Query: 117 LEPPQFVKE--PERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 174
L PP+ + + P +ITA + + + C+A G+PPP+I W++ V + T
Sbjct: 1156 LVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLA--- 1212
Query: 175 GG--LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDST--VIDGMS 230
GG L+++ D+G++ C A N AGE + + + V + P+I L+ V+DG +
Sbjct: 1213 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL-VPPSIENEDLEEVIKVLDGQT 1271
Query: 231 VVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLAT 290
L C +G P+P +TW K R LA G +P + L + ++S AG Y+C+A
Sbjct: 1272 AHLMCNVTGHPQPKLTWFKDGRPLARGDAH--HISP-DGVLLQVLQANLSSAGHYSCIAA 1328
Query: 291 NSRGVDEASADLVVWARTRITKPPQDQ-----SVIKGTQASMVCGVTHDPRVTIRQLRPG 345
N+ G L V I +D +V S++C P I ++ G
Sbjct: 1329 NAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDG 1388
Query: 346 AP 347
AP
Sbjct: 1389 AP 1390
Score = 102 bits (254), Expect = 6e-22
Identities = 89/305 (29%), Positives = 128/305 (41%), Gaps = 32/305 (10%)
Query: 52 PTRPLIKLHIIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPS 107
P R +H+ W KDG+ L + L I +DAG + C A +S
Sbjct: 2145 PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVA---ASPAGV 2201
Query: 108 VVRGAYLSVLEPPQFVKEP---ERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE 164
R L V PP V EP + + +V++PC+A+GVP P ++W KD E
Sbjct: 2202 ADRNFTLQVQVPP--VLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDG-----E 2254
Query: 165 KLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI--TRGPLD 222
L LQ+ + D+G + C A + AGE + L V P+I + P +
Sbjct: 2255 PLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME-PPHIEDSGQPTE 2313
Query: 223 STVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDA 282
++ G + L C+ G P+P ITW K + L T LE+ S + DA
Sbjct: 2314 LSLTPGAPMELLCDAQGTPQPNITWHKDGQAL----------TRLENNSRATRVLRVRDA 2363
Query: 283 GTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMV--CGVTHDPRVTIR 340
G YTCLA + G E S + V A I P + V+ +V C V +P I
Sbjct: 2364 GLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT 2423
Query: 341 QLRPG 345
R G
Sbjct: 2424 WHRDG 2428
Score = 101 bits (252), Expect = 1e-21
Identities = 91/325 (28%), Positives = 134/325 (41%), Gaps = 22/325 (6%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I W ++G+ S + + + L + +DA Y C A ++ S + L V
Sbjct: 1686 ISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT---LRV 1742
Query: 117 LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
PP+ +TA + V +PC P P +TWYKD+ + + + F
Sbjct: 1743 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEV-FLLPGTHT 1801
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAP---NITRGPLDSTVID-GMSVV 232
LQ+ D+GM+ C A NAAG Q L+V + P RGP D+ ++ G V
Sbjct: 1802 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVL-VPPAFRQAPRGPQDAVLVRVGDKAV 1860
Query: 233 LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATN 291
L+CET P P +TW K + L V R L G L I +SD G Y+C +N
Sbjct: 1861 LSCETDALPEPTVTWYKDGQPL----VLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSN 1916
Query: 292 SRGVDEASADLVVWARTRITKPPQDQ-SVIKGTQASMVCGVTHDPRVTIRQLRPGAP--- 347
G + L V P + S + G+ + C V+ P T+ L+ P
Sbjct: 1917 VAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 1976
Query: 348 SGGHWTYDSLYSHPQMRLRGAQVGT 372
S H RL+ AQ GT
Sbjct: 1977 SAVHGVVSRGGRLQLSRLQPAQAGT 2001
Score = 100 bits (249), Expect = 2e-21
Identities = 85/299 (28%), Positives = 128/299 (42%), Gaps = 17/299 (5%)
Query: 61 IIWKKDGVLLSGG------ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 114
++W KDG +S + R LT+ + SD+G Y C AV S+V + L
Sbjct: 818 LMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV---SAVGEDRQDVVL 874
Query: 115 SVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 174
V PP + E E +++ + V + CQ+ +PPP ++W+KD +E +
Sbjct: 875 QVHMPPSILGE-ELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHL-SADK 932
Query: 175 GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLA 234
LQ+ D G + C A N AG + L V R TV +G L+
Sbjct: 933 ALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLS 992
Query: 235 CETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSR 293
CE G P P I+W+K + L L + + G LL + ++ GTYTC +N
Sbjct: 993 CECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV--GRLLYLGQAQLAQEGTYTCECSNVV 1050
Query: 294 GVDEASADLVVWARTRIT---KPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSG 349
G L V +I +PP SV++ A++ C T P T+ R G P G
Sbjct: 1051 GNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVG 1109
Score = 98.6 bits (244), Expect = 9e-21
Identities = 77/245 (31%), Positives = 106/245 (43%), Gaps = 14/245 (5%)
Query: 63 WKKDGVLLSGGISDHNRRLTIPNPTGS--DAGYYECEAVLRSSSVPSVVRGAYLSVLEPP 120
W + ++ G+S+ + T+ S D+G Y C A R +V +++ V E P
Sbjct: 2971 WTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAV---SFVHVKEAP 3027
Query: 121 QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQIS 180
E ++ + + + C +G P P I W KD + L Q +G L I
Sbjct: 3028 VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH--QLQNGSLTIH 3085
Query: 181 GLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGA 240
DD G +QC A N G + L + S AP P D TV G V L C+ +G
Sbjct: 3086 RTERDDAGRYQCLAENEMGVAKKVVILVLQS-APVFQVEPQDMTVRSGDDVALRCQATGE 3144
Query: 241 PRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEAS 299
P P I W Q G+ + AS R L GSL + DAGTY C+A N G A
Sbjct: 3145 PTPTIEWLQAGQPLRASR-----RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 3199
Query: 300 ADLVV 304
A LVV
Sbjct: 3200 AFLVV 3204
Score = 97.8 bits (242), Expect = 2e-20
Identities = 77/297 (25%), Positives = 127/297 (42%), Gaps = 19/297 (6%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I W +DG++L + R L + + +D+G Y C A + S R + +
Sbjct: 2422 ITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR---VEI 2478
Query: 117 LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
P P + + + +PCQA GVP P ++W KD ++ + RF +G
Sbjct: 2479 HTVPTIRSGPPA-VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD-PRSPRFEILPEGS 2536
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACE 236
L+I ++ D G + C A N+AG + L V P I P + T+ +L CE
Sbjct: 2537 LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE-PPAIAPSPSNLTLTAHTPALLPCE 2595
Query: 237 TSGAPRPAITWQK-GERI---LASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 292
SG+P+P + W K G+++ L G+ +L L S +LL++ D+ + C+ +N
Sbjct: 2596 ASGSPKPLVVWWKDGQKLDFRLQQGAYRL-----LPSNALLLTAPGPQDSAQFECVVSNE 2650
Query: 293 RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSG 349
G + V I D +V + C T P T+ + GA G
Sbjct: 2651 VGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLG 2707
Score = 97.4 bits (241), Expect = 2e-20
Identities = 83/276 (30%), Positives = 124/276 (44%), Gaps = 33/276 (11%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
+ W KDG L+ G IS L + S AG+Y C A +++V + LSV
Sbjct: 1286 LTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIA---ANAVGEKTKHFQLSV 1342
Query: 117 LEPPQFVKEPE----RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 172
L P + E +T + + + C+A P P+ITW KD A E + +
Sbjct: 1343 LLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPG 1402
Query: 173 NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG-PLDSTVIDGM-- 229
G LQI +D G + C N GE + ++ V I P+I++ PL + +
Sbjct: 1403 THG-LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IPPSISKDDPLGEVGVKEVKT 1460
Query: 230 ----SVVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLL-ISPTHISDAG 283
++ L CE+ P P I W K G+ + S +Q+ L G LL I PT +SD+G
Sbjct: 1461 KVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQV-----LGEGRLLQIQPTQVSDSG 1515
Query: 284 TYTCLATNSRGVDEASADLVVWARTRITKPPQDQSV 319
Y C+ATN G D+ +++ I PP Q V
Sbjct: 1516 RYLCVATNVAGEDDQDFNVL------IQVPPMFQKV 1545
Score = 90.5 bits (223), Expect = 2e-18
Identities = 59/172 (34%), Positives = 84/172 (48%), Gaps = 5/172 (2%)
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACE 236
LQI + D G++ C A N AGE + L V + PNI GP++ V++ SV L C
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECL 717
Query: 237 TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 296
SG P P ++W KG + ++S + ++ L I +SDAG+Y C+A+N G
Sbjct: 718 ASGVPPPDVSWFKGHQPVSS---WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 774
Query: 297 EASADLVVWARTRITKPPQ-DQSVIKGTQASMVCGVTHDPRVTIRQLRPGAP 347
E L V RIT PP V+ T + C T P T+ L+ G P
Sbjct: 775 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP 826
Score = 89.7 bits (221), Expect = 4e-18
Identities = 87/327 (26%), Positives = 136/327 (41%), Gaps = 35/327 (10%)
Query: 63 WKKDGV-LLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL 117
W KD +L GG + + + L I D G Y+C A S R L V
Sbjct: 251 WTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAF---SPAGQQARDFQLRVH 307
Query: 118 EPPQFVKEPERHITAEMEK-VVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
PP E A ME +V + C+A+GVP P+ITW+KD A++ + R
Sbjct: 308 APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY-TRGGRQ 366
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG---PLDSTVIDGMSVVL 233
LQ+ D G++ C A NA G + +T L V + P I P + G V L
Sbjct: 367 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVPPTIEGAGGRPYVVKAVAGRPVAL 425
Query: 234 ACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 292
C G P P ++W +G + S +L + L + + +G Y+C+A++
Sbjct: 426 ECVARGHPSPTLSWHHEGLPVAESNESRL----ETDGSVLRLESPGEASSGLYSCVASSP 481
Query: 293 RG--VDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGG 350
G V + S ++ V + + + + I G + C + P TI+ L+ G P+
Sbjct: 482 AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPA-- 539
Query: 351 HWTYDSLYSHPQMRLRGAQVGTRGSRL 377
L G QV ++G+ L
Sbjct: 540 ------------EELAGVQVASQGTTL 554
Score = 84.7 bits (208), Expect = 1e-16
Identities = 78/298 (26%), Positives = 122/298 (40%), Gaps = 26/298 (8%)
Query: 61 IIWKKDGVLLSGGISDHNR------RLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 114
+ W KDG L + H R L + SDAG Y C A + R +
Sbjct: 2058 VAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVA---HNPAGEDARLHTV 2114
Query: 115 SVLEPPQFVKEPERH--ITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 172
+VL PP + + + + ++V + C +G PP ++W KD + + + T
Sbjct: 2115 NVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRT-LLHG 2173
Query: 173 NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI--TRGPLDSTVIDGMS 230
+ L+IS + D G+F C A + AG + L V + P + D V+ G
Sbjct: 2174 SGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV-QVPPVLEPVEFQNDVVVVRGSL 2232
Query: 231 VVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 289
V L CE G P P ++W K GE +L+ Q P SL + D+GTY+C+A
Sbjct: 2233 VELPCEARGVPLPLVSWMKDGEPLLSQSLEQGP--------SLQLEAVGAGDSGTYSCVA 2284
Query: 290 TNSRGVDEASADLVVWARTRI--TKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPG 345
+ G L V I + P + S+ G ++C P+ I + G
Sbjct: 2285 VSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 2342
Score = 83.6 bits (205), Expect = 3e-16
Identities = 74/261 (28%), Positives = 105/261 (40%), Gaps = 12/261 (4%)
Query: 90 DAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPP 149
D G Y C A ++ R L VL PP P E V + C A GVPP
Sbjct: 668 DEGIYTCAA---TNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVT-LECLASGVPP 723
Query: 150 PSITWYKDAAVVEVEKLTRFRQRNDGG-LQISGLVPDDTGMFQCFARNAAGEVQTSTYLA 208
P ++W+K V DG L+I D G ++C A N AG + L
Sbjct: 724 PDVSWFKGHQ--PVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLR 781
Query: 209 VTSIAPNITRGP-LDSTVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQLPRFTP 266
V ++ P IT P L V+ V L C +GAP P + W K G + +G+ L F
Sbjct: 782 V-NVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFP- 839
Query: 267 LESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQAS 326
L ++ SD+G Y+C+A ++ G D L V I + SV+ +
Sbjct: 840 -GGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVA 898
Query: 327 MVCGVTHDPRVTIRQLRPGAP 347
+ C P + + G P
Sbjct: 899 LECQSHAMPPPVLSWWKDGRP 919
Score = 83.6 bits (205), Expect = 3e-16
Identities = 83/284 (29%), Positives = 114/284 (40%), Gaps = 19/284 (6%)
Query: 74 ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY-LSVLEPPQFVKEPERHITA 132
+S R L I SDAG Y C A S+V Y L V PP+ P
Sbjct: 743 VSVDGRVLRIEQAQLSDAGSYRCVA----SNVAGSTELRYGLRVNVPPRITLPPSLPGPV 798
Query: 133 EMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG--LQISGLVPDDTGMF 190
+ V + C A G P P++ W KD V T Q GG L ++ D+G +
Sbjct: 799 LVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAG-TPGLQVFPGGRVLTLASARASDSGRY 857
Query: 191 QCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKG 250
C A +A GE + L V + P+I L+ +V+ SV L C++ P P ++W K
Sbjct: 858 SCVAVSAVGEDRQDVVLQV-HMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKD 916
Query: 251 ERILASGSVQLPR---FTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW-A 306
R L PR + L + + DAG YTC A N G E +L VW A
Sbjct: 917 GRPLE------PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVA 970
Query: 307 RTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGG 350
+ +V +G S+ C P I + G P G
Sbjct: 971 PVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPG 1014
Score = 83.2 bits (204), Expect = 4e-16
Identities = 72/260 (27%), Positives = 111/260 (42%), Gaps = 23/260 (8%)
Query: 60 HIIWKKDGVLLSGGI----SDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLS 115
+I W KDG LL + R+L + SDAG Y C+A S++V + + L
Sbjct: 342 NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKA---SNAVGAAEKATRLD 398
Query: 116 VLEPPQFVKEPERH--ITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN 173
V PP R + A + V + C A+G P P+++W+ + + V + R
Sbjct: 399 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG--LPVAESNESRLET 456
Query: 174 DGG-LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPN--ITRGPLDSTVIDGMS 230
DG L++ +G++ C A + AGE Y + P + G T I G
Sbjct: 457 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQ-YSVEVQVPPQLLVAEGLGQVTTIVGQP 515
Query: 231 VVLACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 289
+ L C+ SG+P P I W Q G VQ+ + +L I + +G + C A
Sbjct: 516 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVAS----QGTTLHIDHVELDHSGLFACQA 571
Query: 290 TNSRGVDEASADLVV---WA 306
TN G A ++ V WA
Sbjct: 572 TNEAGTAGAEVEVSVHGEWA 591
Score = 72.0 bits (175), Expect = 9e-13
Identities = 86/307 (28%), Positives = 122/307 (39%), Gaps = 44/307 (14%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSS----------VP 106
I W KDG ++ + R L I SD+G Y C A + VP
Sbjct: 1480 IRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVP 1539
Query: 107 SVVR--GAYLSVLEPPQFVKEPERHITAEMEKVVDIP----CQAKGVPPPSITWYKD--- 157
+ + G + + E +E +T E V + P C +PPP +TWY++
Sbjct: 1540 PMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQP 1599
Query: 158 -AAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI 216
+A EV L R LQI + ++ G + C A N GE L V + P +
Sbjct: 1600 LSAGDEVSVLQGGRV-----LQIPLVRAENAGRYSCKASNEVGEDWLHYELLV--LTPPV 1652
Query: 217 TRGPLDS-----TVIDGMSVVLACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESG 270
G + TV +V L C G P P I+W Q G S PR LE G
Sbjct: 1653 ILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPS-----PRLQVLEDG 1707
Query: 271 SLL-ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQ-SVIKGTQASMV 328
+L +S ++DA +Y C+A N G E L V RI +Q + I + S+
Sbjct: 1708 QVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLP 1767
Query: 329 CGVTHDP 335
C V P
Sbjct: 1768 CDVHAHP 1774
Score = 71.2 bits (173), Expect = 2e-12
Identities = 63/218 (28%), Positives = 91/218 (41%), Gaps = 15/218 (6%)
Query: 138 VDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG-LQISGLVPDDTGMFQCFARN 196
V++ C GVP P + W KD V + + + DG L+I+G D G +QC A +
Sbjct: 235 VELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFS 293
Query: 197 AAGEVQTSTYLAVTSIAPNITRGPLDS---TVIDGMSVVLACETSGAPRPAITWQKGERI 253
AG+ L V AP G ++ V++ V L CE G P P ITW K +
Sbjct: 294 PAGQQARDFQLRVH--APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL 351
Query: 254 LASGSVQLPRFTPLESG-SLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITK 312
L + + + G L + SDAG YTC A+N+ G E + L V+ I
Sbjct: 352 LPTST----KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEG 407
Query: 313 P---PQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAP 347
P + G ++ C P T+ G P
Sbjct: 408 AGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLP 445
Score = 70.1 bits (170), Expect = 3e-12
Identities = 77/298 (25%), Positives = 119/298 (39%), Gaps = 38/298 (12%)
Query: 81 LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPER-HITAEMEKVVD 139
L + + + +D+G YEC+A ++ V S R A L V PP ++ + +++ + +
Sbjct: 59 LFLASVSPADSGDYECQA---TNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLT 115
Query: 140 IPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFAR---- 195
+ C A G P P I W KDA +V V + G Q+ G D G F R
Sbjct: 116 LECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPG 175
Query: 196 -------NAAGEVQTS--------------TYLAVTSIAPNITRGPLDSTVIDGMS---V 231
A G QT T A + AP G + + G++ V
Sbjct: 176 RSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADV 235
Query: 232 VLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLAT 290
L C TSG P P + W K + + G P E G +L I+ +H+ D G Y C+A
Sbjct: 236 ELQCWTSGVPTPQVEWTKDRQPVLPGG---PHLQVQEDGQVLRITGSHVGDEGRYQCVAF 292
Query: 291 NSRGVDEASADLVVWARTRI--TKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGA 346
+ G L V A I + + +V++ ++C P I + GA
Sbjct: 293 SPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGA 350
Score = 54.3 bits (129), Expect = 2e-07
Identities = 41/156 (26%), Positives = 60/156 (38%), Gaps = 28/156 (17%)
Query: 142 CQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEV 201
C G P P +TW K + + +G L ++ + P D+G ++C A N G
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83
Query: 202 QTSTYLAVTSIAPNITRGPLDSTV--IDGMSVVLACETSGAPRPAITWQK---------- 249
L V + P+I + V + G S+ L C+ +G P P I W K
Sbjct: 84 SRRAKLVVY-VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLG 142
Query: 250 --------------GERILASG-SVQLPRFTPLESG 270
G R+L G S+ PR P SG
Sbjct: 143 WAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSG 178
Score = 51.6 bits (122), Expect = 1e-06
Identities = 45/162 (27%), Positives = 66/162 (40%), Gaps = 22/162 (13%)
Query: 235 CETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRG 294
C T G P+P +TW+KG + P LE GSL ++ +D+G Y C ATN G
Sbjct: 24 CGTHGTPKPQVTWRKGPS--SEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG 81
Query: 295 VDEASADLVVWARTRITKPPQDQSV--IKGTQASMVCGVTHDPRVTIRQLRP----GAP- 347
A LVV+ I + + +V + G ++ C P I L+ G P
Sbjct: 82 STSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPL 141
Query: 348 -------------SGGHWTYDSLYSHPQMRLRGAQVGTRGSR 376
GGH D S R++ + G RG++
Sbjct: 142 GWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQ 183
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 122 bits (307), Expect = 4e-28
Identities = 90/288 (31%), Positives = 131/288 (45%), Gaps = 16/288 (5%)
Query: 50 QGPTRPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVV 109
QG +P +I W KDG L+ ++N R T DAG Y C L S ++
Sbjct: 3520 QGTPQP----NITWHKDGQALTR--LENNSRATRVLRV-RDAGLYTC---LAESPAGAIE 3569
Query: 110 RGAYLSVLEPPQFV-KEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTR 168
+ + V PP V R + + + C + P P ITW++D V++ + T+
Sbjct: 3570 KSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQ 3629
Query: 169 FRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDG 228
F +R LQ+ L D+G + C ARNAAG + + + ++ P I GP V
Sbjct: 3630 FPERGRF-LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV-PTIRSGPPAVNVSVN 3687
Query: 229 MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 288
+ +L C+ G P P ++W+K L S PRF L GSL I P DAG Y CL
Sbjct: 3688 QTALLPCQADGVPAPLVSWRKDRVPLDPRS---PRFEILPEGSLRIQPVLAQDAGHYLCL 3744
Query: 289 ATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPR 336
A+NS G D DL V I P + ++ T A + C + P+
Sbjct: 3745 ASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPK 3792
Score = 114 bits (285), Expect = 2e-25
Identities = 92/307 (29%), Positives = 132/307 (42%), Gaps = 22/307 (7%)
Query: 51 GPTRPLIKLHIIWKKDGVLLSGGISDHNRRLTIPN------PTGSDAGYYECEAVLRSSS 104
G +PL+ +W KDG L + RL N P D+ +EC S+
Sbjct: 3789 GSPKPLV----VWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVV---SNE 3841
Query: 105 VPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE 164
V R ++V PP + + + T M V + C + G+P P+++W K A +
Sbjct: 3842 VGEAHRLYQVTVHVPPT-IADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGAR 3900
Query: 165 KLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDST 224
+ +R G L+I +P G + C ARN+AG +L V + +P + P
Sbjct: 3901 G-SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQA-SPVVKPLPSVVR 3958
Query: 225 VIDGMSVVLACETSGAPRPAITWQKGERILASG-SVQLPRFTPLESGSLLISPTHISDAG 283
+ V+L CE SG PRP ITWQK +A+G S Q+ L G L I+ DAG
Sbjct: 3959 AVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV-----LPGGQLRIAHASPEDAG 4013
Query: 284 TYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLR 343
Y C+A NS G LVV I D S +G+ A + C P I +
Sbjct: 4014 NYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK 4073
Query: 344 PGAPSGG 350
G P G
Sbjct: 4074 DGQPVSG 4080
Score = 113 bits (283), Expect = 3e-25
Identities = 91/301 (30%), Positives = 124/301 (41%), Gaps = 25/301 (8%)
Query: 61 IIWKKDGV---------LLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRG 111
+ W KDG L GG +RL I SD G Y C+ S+ VR
Sbjct: 3064 VTWYKDGQPLVLAQRTQALRGG-----QRLEIQEAQVSDKGLYSCKV---SNVAGEAVRT 3115
Query: 112 AYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQ 171
L+V PP F ++ + + C GVP P++TW KD VE +
Sbjct: 3116 FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVS 3175
Query: 172 RNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPL--DSTVIDGM 229
R G LQ+S L P G + C A N E + +AV +AP I + + V++G
Sbjct: 3176 RG-GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVL-VAPRIRSSGVAREHHVLEGQ 3233
Query: 230 SVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 289
V L CE G P P + W K L RF L+ GSL++ SDAG YTC+A
Sbjct: 3234 EVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY-LDGGSLVLKGLRASDAGAYTCVA 3292
Query: 290 TNSRGVDEASADLVVWARTRITKPPQDQSVI---KGTQASMVCGVTHDPRVTIRQLRPGA 346
N G D + V I + + G +MVC V P + + L+ G
Sbjct: 3293 HNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGL 3352
Query: 347 P 347
P
Sbjct: 3353 P 3353
Score = 112 bits (279), Expect = 8e-25
Identities = 88/267 (32%), Positives = 122/267 (45%), Gaps = 24/267 (8%)
Query: 89 SDAGYYECEAVLRSSSVPSVVRGA-YLSVLEPPQF-VKEPERHITAEMEKVVDIPCQAKG 146
+D G Y+C A S+ V R + +L V E PQ + +H + +E V + C A G
Sbjct: 580 TDGGRYQCVA----SNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE--VKVSCSASG 633
Query: 147 VPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTY 206
P P I+W +++ ++ + +R G L I G+ P+D G + C A N G Q +
Sbjct: 634 YPTPHISWSRESQALQED--SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVT 691
Query: 207 LAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKG--ERILA-SGSVQLPR 263
L T P+++ V G VL CE SG P P + W +G E ILA GS
Sbjct: 692 LYYTD-PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS----- 745
Query: 264 FTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGT 323
SG L I DAGTYTC A N G A L V ++T+ P+D +V G
Sbjct: 746 ----SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGR 801
Query: 324 QASMVCGVTHDPRVTIRQLR-PGAPSG 349
A + C T P T+ R G P G
Sbjct: 802 SALLACRATGRPPPTVTWRRGDGQPLG 828
Score = 110 bits (275), Expect = 2e-24
Identities = 96/327 (29%), Positives = 140/327 (42%), Gaps = 23/327 (7%)
Query: 61 IIWKKDGV-LLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEP 119
+IW + G+ ++ + +L IP DAG Y C AV + ++ L+V
Sbjct: 729 VIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQ---LAVGHA 785
Query: 120 PQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKL-----TRFRQRND 174
PQ + P R +T E+ + + C+A G PPP++TW + +L +R RQ +
Sbjct: 786 PQLTELP-RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS 844
Query: 175 GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIA-PNITRGPLDSTVIDGMSVVL 233
G L + P+D + C ARN G+VQ L VT A P I V++G V L
Sbjct: 845 GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSL 904
Query: 234 AC-ETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 292
C +G P P W K R L GS R + GSL + AG Y+C+ATN+
Sbjct: 905 PCIVLAGRPLPERHWLKDGRPLPPGS----RHSIRADGSLHLDRALQEHAGRYSCVATNT 960
Query: 293 RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTI---RQLRPGAPSG 349
G +LVV RI +G AS+ C + P TI ++ G
Sbjct: 961 AGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRG 1020
Query: 350 GHWTYDS----LYSHPQMRLRGAQVGT 372
H+ L + P + GA V T
Sbjct: 1021 PHYNVSKEGTLLIAQPSAQDAGAYVCT 1047
Score = 110 bits (274), Expect = 3e-24
Identities = 91/296 (30%), Positives = 133/296 (44%), Gaps = 23/296 (7%)
Query: 60 HIIWKKDGVLLSGGISDH----NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLS 115
+I W KDG +SG + L + N G DAG Y C A ++V R +L+
Sbjct: 4068 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTA---ENAVGRARRRVHLT 4124
Query: 116 VLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG 175
+L P F P + + + + C A+G P P I W V +T DG
Sbjct: 4125 ILVLPVFTTLPGDR-SLRLGDRLWLRCAARGSPTPRIGW-----TVNDRPVTEGVSEQDG 4178
Query: 176 G--LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID--GMSV 231
G LQ + + +D+G + C+A N G Q +++ V AP + +G S +++ G S+
Sbjct: 4179 GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE-AP-VLQGEAFSYLVEPVGGSI 4236
Query: 232 VLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATN 291
L C G P P I W K L ++ L++GSL I T DAG Y CLA N
Sbjct: 4237 QLDCVVRGDPVPDIHWIKDGLPLRGSHLR----HQLQNGSLTIHRTERDDAGRYQCLAEN 4292
Query: 292 SRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAP 347
GV + LV+ + PQD +V G ++ C T +P TI L+ G P
Sbjct: 4293 EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQP 4348
Score = 105 bits (263), Expect = 6e-23
Identities = 78/266 (29%), Positives = 118/266 (44%), Gaps = 15/266 (5%)
Query: 89 SDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVP 148
++ G YEC AV R+ + + + PPQ V P ++T + + C+ G
Sbjct: 489 AEEGTYECTAVSRAGT--GRAKAQIVVTDPPPQLVPAP--NVTVSPGETAVLSCRVLGEA 544
Query: 149 PPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLA 208
P ++TW +D V+ R Q D L+ISG++P D G +QC A NA G + S +L
Sbjct: 545 PYNLTWVRDWRVLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLL 603
Query: 209 VTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLE 268
V AP ++ G+ V ++C SG P P I+W + + L S R
Sbjct: 604 VRE-APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS----RIHVDA 658
Query: 269 SGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMV 328
G+L+I DAG Y+C ATN G D+ + L ++ V G +A +V
Sbjct: 659 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 718
Query: 329 CGVTHDPRVTIRQLRPG-----APSG 349
C + P + R G AP G
Sbjct: 719 CEASGVPPPRVIWYRGGLEMILAPEG 744
Score = 104 bits (259), Expect = 2e-22
Identities = 88/303 (29%), Positives = 128/303 (42%), Gaps = 27/303 (8%)
Query: 61 IIWKKDGVLLSGG------ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 114
I W+KDG L G +S R L + + G Y CE S+ V + + L
Sbjct: 2194 ISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCEC---SNVVGNSSQDLQL 2250
Query: 115 SVLEPPQFV--KEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 172
V PPQ +EP ++ + V + C A G PPP++TW +D V E L Q
Sbjct: 2251 EVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAE-LGLQLQN 2309
Query: 173 NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS----TVIDG 228
L + TG + C A N AG + L+V + P G LD T
Sbjct: 2310 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSV--LVPPELIGDLDPLTNITAALH 2367
Query: 229 MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGS--LLISPTHISDAGTYT 286
+ L CE G P PAI W +GE ++ G T L +G L ++ T D+G Y+
Sbjct: 2368 SPLTLLCEAMGIPPPAIRWFRGEEPVSPG-----EDTYLLAGGWMLKMTQTQEQDSGLYS 2422
Query: 287 CLATNSRGVDEASADLVVWARTRITKPPQDQ--SVIKGTQASMVCGVTHDPRVTIRQLRP 344
CLA+N G + + V I ++ V+ G A ++C VT P+ + +
Sbjct: 2423 CLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKD 2482
Query: 345 GAP 347
G P
Sbjct: 2483 GRP 2485
Score = 103 bits (258), Expect = 2e-22
Identities = 82/302 (27%), Positives = 135/302 (44%), Gaps = 25/302 (8%)
Query: 61 IIWKKDG----VLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
+ W++DG L + + + L + + G Y C A + R LSV
Sbjct: 2290 VTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVA---ENLAGRAERKFELSV 2346
Query: 117 LEPPQFVKE--PERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 174
L PP+ + + P +ITA + + + C+A G+PPP+I W++ V + T
Sbjct: 2347 LVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLA--- 2403
Query: 175 GG--LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDST--VIDGMS 230
GG L+++ D+G++ C A N AGE + + + V + P+I L+ V+DG +
Sbjct: 2404 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL-VPPSIENEDLEEVIKVLDGQT 2462
Query: 231 VVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLAT 290
L C +G P+P +TW K R LA G +P + L + ++S AG Y+C+A
Sbjct: 2463 AHLMCNVTGHPQPKLTWFKDGRPLARGDAH--HISP-DGVLLQVLQANLSSAGHYSCIAA 2519
Query: 291 NSRGVDEASADLVVWARTRITKPPQDQ-----SVIKGTQASMVCGVTHDPRVTIRQLRPG 345
N+ G L V I +D +V S++C P I ++ G
Sbjct: 2520 NAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDG 2579
Query: 346 AP 347
AP
Sbjct: 2580 AP 2581
Score = 102 bits (254), Expect = 6e-22
Identities = 89/305 (29%), Positives = 128/305 (41%), Gaps = 32/305 (10%)
Query: 52 PTRPLIKLHIIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPS 107
P R +H+ W KDG+ L + L I +DAG + C A +S
Sbjct: 3336 PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVA---ASPAGV 3392
Query: 108 VVRGAYLSVLEPPQFVKEP---ERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE 164
R L V PP V EP + + +V++PC+A+GVP P ++W KD E
Sbjct: 3393 ADRNFTLQVQVPP--VLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDG-----E 3445
Query: 165 KLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI--TRGPLD 222
L LQ+ + D+G + C A + AGE + L V P+I + P +
Sbjct: 3446 PLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME-PPHIEDSGQPTE 3504
Query: 223 STVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDA 282
++ G + L C+ G P+P ITW K + L T LE+ S + DA
Sbjct: 3505 LSLTPGAPMELLCDAQGTPQPNITWHKDGQAL----------TRLENNSRATRVLRVRDA 3554
Query: 283 GTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMV--CGVTHDPRVTIR 340
G YTCLA + G E S + V A I P + V+ +V C V +P I
Sbjct: 3555 GLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT 3614
Query: 341 QLRPG 345
R G
Sbjct: 3615 WHRDG 3619
Score = 101 bits (252), Expect = 1e-21
Identities = 91/325 (28%), Positives = 134/325 (41%), Gaps = 22/325 (6%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I W ++G+ S + + + L + +DA Y C A ++ S + L V
Sbjct: 2877 ISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT---LRV 2933
Query: 117 LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
PP+ +TA + V +PC P P +TWYKD+ + + + F
Sbjct: 2934 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEV-FLLPGTHT 2992
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAP---NITRGPLDSTVID-GMSVV 232
LQ+ D+GM+ C A NAAG Q L+V + P RGP D+ ++ G V
Sbjct: 2993 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVL-VPPAFRQAPRGPQDAVLVRVGDKAV 3051
Query: 233 LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATN 291
L+CET P P +TW K + L V R L G L I +SD G Y+C +N
Sbjct: 3052 LSCETDALPEPTVTWYKDGQPL----VLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSN 3107
Query: 292 SRGVDEASADLVVWARTRITKPPQDQ-SVIKGTQASMVCGVTHDPRVTIRQLRPGAP--- 347
G + L V P + S + G+ + C V+ P T+ L+ P
Sbjct: 3108 VAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 3167
Query: 348 SGGHWTYDSLYSHPQMRLRGAQVGT 372
S H RL+ AQ GT
Sbjct: 3168 SAVHGVVSRGGRLQLSRLQPAQAGT 3192
Score = 100 bits (249), Expect = 2e-21
Identities = 85/299 (28%), Positives = 128/299 (42%), Gaps = 17/299 (5%)
Query: 61 IIWKKDGVLLSGG------ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 114
++W KDG +S + R LT+ + SD+G Y C AV S+V + L
Sbjct: 2009 LMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV---SAVGEDRQDVVL 2065
Query: 115 SVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 174
V PP + E E +++ + V + CQ+ +PPP ++W+KD +E +
Sbjct: 2066 QVHMPPSILGE-ELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHL-SADK 2123
Query: 175 GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLA 234
LQ+ D G + C A N AG + L V R TV +G L+
Sbjct: 2124 ALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLS 2183
Query: 235 CETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSR 293
CE G P P I+W+K + L L + + G LL + ++ GTYTC +N
Sbjct: 2184 CECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV--GRLLYLGQAQLAQEGTYTCECSNVV 2241
Query: 294 GVDEASADLVVWARTRIT---KPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSG 349
G L V +I +PP SV++ A++ C T P T+ R G P G
Sbjct: 2242 GNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVG 2300
Score = 98.6 bits (244), Expect = 9e-21
Identities = 77/245 (31%), Positives = 106/245 (43%), Gaps = 14/245 (5%)
Query: 63 WKKDGVLLSGGISDHNRRLTIPNPTGS--DAGYYECEAVLRSSSVPSVVRGAYLSVLEPP 120
W + ++ G+S+ + T+ S D+G Y C A R +V +++ V E P
Sbjct: 4162 WTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAV---SFVHVKEAP 4218
Query: 121 QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQIS 180
E ++ + + + C +G P P I W KD + L Q +G L I
Sbjct: 4219 VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH--QLQNGSLTIH 4276
Query: 181 GLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGA 240
DD G +QC A N G + L + S AP P D TV G V L C+ +G
Sbjct: 4277 RTERDDAGRYQCLAENEMGVAKKVVILVLQS-APVFQVEPQDMTVRSGDDVALRCQATGE 4335
Query: 241 PRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEAS 299
P P I W Q G+ + AS R L GSL + DAGTY C+A N G A
Sbjct: 4336 PTPTIEWLQAGQPLRASR-----RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 4390
Query: 300 ADLVV 304
A LVV
Sbjct: 4391 AFLVV 4395
Score = 97.8 bits (242), Expect = 2e-20
Identities = 77/297 (25%), Positives = 127/297 (42%), Gaps = 19/297 (6%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I W +DG++L + R L + + +D+G Y C A + S R + +
Sbjct: 3613 ITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR---VEI 3669
Query: 117 LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
P P + + + +PCQA GVP P ++W KD ++ + RF +G
Sbjct: 3670 HTVPTIRSGPPA-VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD-PRSPRFEILPEGS 3727
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACE 236
L+I ++ D G + C A N+AG + L V P I P + T+ +L CE
Sbjct: 3728 LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE-PPAIAPSPSNLTLTAHTPALLPCE 3786
Query: 237 TSGAPRPAITWQK-GERI---LASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 292
SG+P+P + W K G+++ L G+ +L L S +LL++ D+ + C+ +N
Sbjct: 3787 ASGSPKPLVVWWKDGQKLDFRLQQGAYRL-----LPSNALLLTAPGPQDSAQFECVVSNE 3841
Query: 293 RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSG 349
G + V I D +V + C T P T+ + GA G
Sbjct: 3842 VGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLG 3898
Score = 97.4 bits (241), Expect = 2e-20
Identities = 83/276 (30%), Positives = 124/276 (44%), Gaps = 33/276 (11%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
+ W KDG L+ G IS L + S AG+Y C A +++V + LSV
Sbjct: 2477 LTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIA---ANAVGEKTKHFQLSV 2533
Query: 117 LEPPQFVKEPE----RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 172
L P + E +T + + + C+A P P+ITW KD A E + +
Sbjct: 2534 LLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPG 2593
Query: 173 NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG-PLDSTVIDGM-- 229
G LQI +D G + C N GE + ++ V I P+I++ PL + +
Sbjct: 2594 THG-LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IPPSISKDDPLGEVGVKEVKT 2651
Query: 230 ----SVVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLL-ISPTHISDAG 283
++ L CE+ P P I W K G+ + S +Q+ L G LL I PT +SD+G
Sbjct: 2652 KVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQV-----LGEGRLLQIQPTQVSDSG 2706
Query: 284 TYTCLATNSRGVDEASADLVVWARTRITKPPQDQSV 319
Y C+ATN G D+ +++ I PP Q V
Sbjct: 2707 RYLCVATNVAGEDDQDFNVL------IQVPPMFQKV 2736
Score = 94.7 bits (234), Expect = 1e-19
Identities = 77/279 (27%), Positives = 121/279 (43%), Gaps = 27/279 (9%)
Query: 62 IWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQ 121
+W++ G+L SG L + D+G+YEC A S+ S L V PPQ
Sbjct: 1072 VWEEYGLLPSGS-------LRLAQVQVGDSGHYECTA---SNPAGSASHRYVLGVQVPPQ 1121
Query: 122 FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISG 181
P R + + + +D+ C A+G P P ++W KD V++ + G + +
Sbjct: 1122 VQPGP-RVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQ-------GRGPQGSVHFAA 1173
Query: 182 LVPDDTGMFQCFARNAAGEVQTSTYLAVTSI---APNITRGPLDSTVIDGMSVVLACETS 238
+ D G ++C A N+AG L V + T G L+ + G + L C
Sbjct: 1174 IRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLER--VAGENASLPCPAR 1231
Query: 239 GAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEA 298
G P+P +TW+KG + P LE GSL ++ +D+G Y C ATN G
Sbjct: 1232 GTPKPQVTWRKGPS--SEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSR 1289
Query: 299 SADLVVWARTRITKPPQDQSV--IKGTQASMVCGVTHDP 335
A LVV+ I + + +V + G ++ C P
Sbjct: 1290 RAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFP 1328
Score = 90.5 bits (223), Expect = 2e-18
Identities = 59/172 (34%), Positives = 84/172 (48%), Gaps = 5/172 (2%)
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACE 236
LQI + D G++ C A N AGE + L V + PNI GP++ V++ SV L C
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECL 1908
Query: 237 TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 296
SG P P ++W KG + ++S + ++ L I +SDAG+Y C+A+N G
Sbjct: 1909 ASGVPPPDVSWFKGHQPVSS---WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 1965
Query: 297 EASADLVVWARTRITKPPQ-DQSVIKGTQASMVCGVTHDPRVTIRQLRPGAP 347
E L V RIT PP V+ T + C T P T+ L+ G P
Sbjct: 1966 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP 2017
Score = 89.7 bits (221), Expect = 4e-18
Identities = 75/285 (26%), Positives = 123/285 (43%), Gaps = 25/285 (8%)
Query: 81 LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPER-HITAEMEKVVD 139
L + + + +D+G YEC+A ++ V S R A L V PP ++ + +++ + +
Sbjct: 1263 LFLASVSPADSGDYECQA---TNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLT 1319
Query: 140 IPCQAKGVPPPSITWYKDAAVVEVE-------------KLTRFRQRNDG-GLQISGLVPD 185
+ C A G P P I W KDA +V V ++ R ++G L +
Sbjct: 1320 LECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEG 1379
Query: 186 DTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTV-IDGMSVVLACETSGAPRPA 244
D+G++ C A N AG Q +L V + + G + + G V L C TSG P P
Sbjct: 1380 DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQ 1439
Query: 245 ITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSRGVDEASADLV 303
+ W K + + G P E G +L I+ +H+ D G Y C+A + G L
Sbjct: 1440 VEWTKDRQPVLPGG---PHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLR 1496
Query: 304 VWARTRI--TKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGA 346
V A I + + +V++ ++C P I + GA
Sbjct: 1497 VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGA 1541
Score = 89.7 bits (221), Expect = 4e-18
Identities = 87/327 (26%), Positives = 136/327 (41%), Gaps = 35/327 (10%)
Query: 63 WKKDGV-LLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL 117
W KD +L GG + + + L I D G Y+C A S R L V
Sbjct: 1442 WTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAF---SPAGQQARDFQLRVH 1498
Query: 118 EPPQFVKEPERHITAEMEK-VVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
PP E A ME +V + C+A+GVP P+ITW+KD A++ + R
Sbjct: 1499 APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY-TRGGRQ 1557
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG---PLDSTVIDGMSVVL 233
LQ+ D G++ C A NA G + +T L V + P I P + G V L
Sbjct: 1558 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVPPTIEGAGGRPYVVKAVAGRPVAL 1616
Query: 234 ACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 292
C G P P ++W +G + S +L + L + + +G Y+C+A++
Sbjct: 1617 ECVARGHPSPTLSWHHEGLPVAESNESRL----ETDGSVLRLESPGEASSGLYSCVASSP 1672
Query: 293 RG--VDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGG 350
G V + S ++ V + + + + I G + C + P TI+ L+ G P+
Sbjct: 1673 AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPA-- 1730
Query: 351 HWTYDSLYSHPQMRLRGAQVGTRGSRL 377
L G QV ++G+ L
Sbjct: 1731 ------------EELAGVQVASQGTTL 1745
Score = 84.7 bits (208), Expect = 1e-16
Identities = 78/298 (26%), Positives = 122/298 (40%), Gaps = 26/298 (8%)
Query: 61 IIWKKDGVLLSGGISDHNR------RLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 114
+ W KDG L + H R L + SDAG Y C A + R +
Sbjct: 3249 VAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVA---HNPAGEDARLHTV 3305
Query: 115 SVLEPPQFVKEPERH--ITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 172
+VL PP + + + + ++V + C +G PP ++W KD + + + T
Sbjct: 3306 NVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRT-LLHG 3364
Query: 173 NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI--TRGPLDSTVIDGMS 230
+ L+IS + D G+F C A + AG + L V + P + D V+ G
Sbjct: 3365 SGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV-QVPPVLEPVEFQNDVVVVRGSL 3423
Query: 231 VVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 289
V L CE G P P ++W K GE +L+ Q P SL + D+GTY+C+A
Sbjct: 3424 VELPCEARGVPLPLVSWMKDGEPLLSQSLEQGP--------SLQLEAVGAGDSGTYSCVA 3475
Query: 290 TNSRGVDEASADLVVWARTRI--TKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPG 345
+ G L V I + P + S+ G ++C P+ I + G
Sbjct: 3476 VSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 3533
Score = 83.6 bits (205), Expect = 3e-16
Identities = 96/363 (26%), Positives = 135/363 (37%), Gaps = 89/363 (24%)
Query: 54 RPLIKLHIIWKKDGVLLSGGISDHNRR----LTIPNPTGSDAGYYECEAVLRSSSVPSVV 109
RPL + H W KDG L G S H+ R L + AG Y C A +++ S
Sbjct: 912 RPLPERH--WLKDGRPLPPG-SRHSIRADGSLHLDRALQEHAGRYSCVA---TNTAGSQH 965
Query: 110 RGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRF 169
R L V PP+ HIT E +PC A GVP P+ITW K+ + + +
Sbjct: 966 RDVELVVQVPPRIHPTATHHITNEGVPA-SLPCVASGVPAPTITWTKETNAL-TSRGPHY 1023
Query: 170 RQRNDGGLQISGLVPDDTGMFQCFARNAAG------------------------------ 199
+G L I+ D G + C A N G
Sbjct: 1024 NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGS 1083
Query: 200 ----EVQ------------------TSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACET 237
+VQ + Y+ + P + GP V+ G ++ L C
Sbjct: 1084 LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVA 1143
Query: 238 SGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDE 297
G P P ++W K +L Q GS+ + SDAG Y C A+NS GVD
Sbjct: 1144 EGNPEPQLSWSKDGVVLQGRGPQ---------GSVHFAAIRTSDAGRYRCEASNSAGVDA 1194
Query: 298 ASADLVVWARTRITKPPQ---DQSV-----IKGTQASMVCGV--THDPRVTIRQLRPGAP 347
+L R+ +PP D++ + G AS+ C T P+VT R+ P
Sbjct: 1195 WEVEL------RVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEP 1248
Query: 348 SGG 350
G
Sbjct: 1249 LHG 1251
Score = 83.6 bits (205), Expect = 3e-16
Identities = 74/261 (28%), Positives = 105/261 (40%), Gaps = 12/261 (4%)
Query: 90 DAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPP 149
D G Y C A ++ R L VL PP P E V + C A GVPP
Sbjct: 1859 DEGIYTCAA---TNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVT-LECLASGVPP 1914
Query: 150 PSITWYKDAAVVEVEKLTRFRQRNDGG-LQISGLVPDDTGMFQCFARNAAGEVQTSTYLA 208
P ++W+K V DG L+I D G ++C A N AG + L
Sbjct: 1915 PDVSWFKGHQ--PVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLR 1972
Query: 209 VTSIAPNITRGP-LDSTVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQLPRFTP 266
V ++ P IT P L V+ V L C +GAP P + W K G + +G+ L F
Sbjct: 1973 V-NVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFP- 2030
Query: 267 LESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQAS 326
L ++ SD+G Y+C+A ++ G D L V I + SV+ +
Sbjct: 2031 -GGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVA 2089
Query: 327 MVCGVTHDPRVTIRQLRPGAP 347
+ C P + + G P
Sbjct: 2090 LECQSHAMPPPVLSWWKDGRP 2110
Score = 83.6 bits (205), Expect = 3e-16
Identities = 83/284 (29%), Positives = 114/284 (40%), Gaps = 19/284 (6%)
Query: 74 ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY-LSVLEPPQFVKEPERHITA 132
+S R L I SDAG Y C A S+V Y L V PP+ P
Sbjct: 1934 VSVDGRVLRIEQAQLSDAGSYRCVA----SNVAGSTELRYGLRVNVPPRITLPPSLPGPV 1989
Query: 133 EMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG--LQISGLVPDDTGMF 190
+ V + C A G P P++ W KD V T Q GG L ++ D+G +
Sbjct: 1990 LVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAG-TPGLQVFPGGRVLTLASARASDSGRY 2048
Query: 191 QCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKG 250
C A +A GE + L V + P+I L+ +V+ SV L C++ P P ++W K
Sbjct: 2049 SCVAVSAVGEDRQDVVLQV-HMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKD 2107
Query: 251 ERILASGSVQLPR---FTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW-A 306
R L PR + L + + DAG YTC A N G E +L VW A
Sbjct: 2108 GRPLE------PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVA 2161
Query: 307 RTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGG 350
+ +V +G S+ C P I + G P G
Sbjct: 2162 PVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPG 2205
Score = 83.2 bits (204), Expect = 4e-16
Identities = 72/260 (27%), Positives = 111/260 (42%), Gaps = 23/260 (8%)
Query: 60 HIIWKKDGVLLSGGI----SDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLS 115
+I W KDG LL + R+L + SDAG Y C+A S++V + + L
Sbjct: 1533 NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKA---SNAVGAAEKATRLD 1589
Query: 116 VLEPPQFVKEPERH--ITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN 173
V PP R + A + V + C A+G P P+++W+ + + V + R
Sbjct: 1590 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG--LPVAESNESRLET 1647
Query: 174 DGG-LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPN--ITRGPLDSTVIDGMS 230
DG L++ +G++ C A + AGE Y + P + G T I G
Sbjct: 1648 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQ-YSVEVQVPPQLLVAEGLGQVTTIVGQP 1706
Query: 231 VVLACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 289
+ L C+ SG+P P I W Q G VQ+ + +L I + +G + C A
Sbjct: 1707 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVAS----QGTTLHIDHVELDHSGLFACQA 1762
Query: 290 TNSRGVDEASADLVV---WA 306
TN G A ++ V WA
Sbjct: 1763 TNEAGTAGAEVEVSVHGEWA 1782
Score = 82.4 bits (202), Expect = 7e-16
Identities = 84/315 (26%), Positives = 123/315 (39%), Gaps = 38/315 (12%)
Query: 61 IIWKKDGVLLS-----------------GG--ISDHNRRLTIPNPTGSDAGYYECEAVLR 101
I+W KD L+ GG + D + L P D+G Y C A
Sbjct: 1332 IVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRA--- 1388
Query: 102 SSSVPSVVRGAYLSVLEPPQFV-KEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAV 160
+ + R +L VL PP + + + V++ C GVP P + W KD
Sbjct: 1389 ENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQP 1448
Query: 161 VEVEKLTRFRQRNDGG-LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG 219
V + + + DG L+I+G D G +QC A + AG+ L V AP G
Sbjct: 1449 V-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVH--APPTIWG 1505
Query: 220 PLDS---TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESG-SLLIS 275
++ V++ V L CE G P P ITW K +L + + + G L +
Sbjct: 1506 SNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST----KVVYTRGGRQLQLG 1561
Query: 276 PTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKP---PQDQSVIKGTQASMVCGVT 332
SDAG YTC A+N+ G E + L V+ I P + G ++ C
Sbjct: 1562 RAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVAR 1621
Query: 333 HDPRVTIRQLRPGAP 347
P T+ G P
Sbjct: 1622 GHPSPTLSWHHEGLP 1636
Score = 78.2 bits (191), Expect = 1e-14
Identities = 78/293 (26%), Positives = 105/293 (35%), Gaps = 23/293 (7%)
Query: 23 GHRTPFPWGPSEYPHGTSRGPLWKIRPQGPTRPLIKLHIIWKKD-----GVLLSGGISDH 77
GH P + R L R G P + W++ G+ L G
Sbjct: 783 GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVT----WRRGDGQPLGLRLGAGRGSR 838
Query: 78 NRR-----LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITA 132
+R+ L + D Y CEA V + R ++ PPQ
Sbjct: 839 SRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEAR-LIVTGHAPPQIASSAPTVRVL 897
Query: 133 EMEKVVDIPCQA-KGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQ 191
E + V +PC G P P W KD + +R R DG L + + + G +
Sbjct: 898 EGQPV-SLPCIVLAGRPLPERHWLKDGRPLPPG--SRHSIRADGSLHLDRALQEHAGRYS 954
Query: 192 CFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGE 251
C A N AG L V + P I +G+ L C SG P P ITW K
Sbjct: 955 CVATNTAGSQHRDVELVV-QVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKET 1013
Query: 252 RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVV 304
L S P + + G+LLI+ DAG Y C ATN+ G L V
Sbjct: 1014 NALTSRG---PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063
Score = 72.0 bits (175), Expect = 9e-13
Identities = 86/307 (28%), Positives = 122/307 (39%), Gaps = 44/307 (14%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSS----------VP 106
I W KDG ++ + R L I SD+G Y C A + VP
Sbjct: 2671 IRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVP 2730
Query: 107 SVVR--GAYLSVLEPPQFVKEPERHITAEMEKVVDIP----CQAKGVPPPSITWYKD--- 157
+ + G + + E +E +T E V + P C +PPP +TWY++
Sbjct: 2731 PMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQP 2790
Query: 158 -AAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI 216
+A EV L R LQI + ++ G + C A N GE L V + P +
Sbjct: 2791 LSAGDEVSVLQGGRV-----LQIPLVRAENAGRYSCKASNEVGEDWLHYELLV--LTPPV 2843
Query: 217 TRGPLDS-----TVIDGMSVVLACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESG 270
G + TV +V L C G P P I+W Q G S PR LE G
Sbjct: 2844 ILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPS-----PRLQVLEDG 2898
Query: 271 SLL-ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQ-SVIKGTQASMV 328
+L +S ++DA +Y C+A N G E L V RI +Q + I + S+
Sbjct: 2899 QVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLP 2958
Query: 329 CGVTHDP 335
C V P
Sbjct: 2959 CDVHAHP 2965
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 122 bits (307), Expect = 4e-28
Identities = 90/288 (31%), Positives = 131/288 (45%), Gaps = 16/288 (5%)
Query: 50 QGPTRPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVV 109
QG +P +I W KDG L+ ++N R T DAG Y C L S ++
Sbjct: 2238 QGTPQP----NITWHKDGQALTR--LENNSRATRVLRV-RDAGLYTC---LAESPAGAIE 2287
Query: 110 RGAYLSVLEPPQFV-KEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTR 168
+ + V PP V R + + + C + P P ITW++D V++ + T+
Sbjct: 2288 KSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQ 2347
Query: 169 FRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDG 228
F +R LQ+ L D+G + C ARNAAG + + + ++ P I GP V
Sbjct: 2348 FPERGRF-LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV-PTIRSGPPAVNVSVN 2405
Query: 229 MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 288
+ +L C+ G P P ++W+K L S PRF L GSL I P DAG Y CL
Sbjct: 2406 QTALLPCQADGVPAPLVSWRKDRVPLDPRS---PRFEILPEGSLRIQPVLAQDAGHYLCL 2462
Query: 289 ATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPR 336
A+NS G D DL V I P + ++ T A + C + P+
Sbjct: 2463 ASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPK 2510
Score = 114 bits (285), Expect = 2e-25
Identities = 92/307 (29%), Positives = 132/307 (42%), Gaps = 22/307 (7%)
Query: 51 GPTRPLIKLHIIWKKDGVLLSGGISDHNRRLTIPN------PTGSDAGYYECEAVLRSSS 104
G +PL+ +W KDG L + RL N P D+ +EC S+
Sbjct: 2507 GSPKPLV----VWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVV---SNE 2559
Query: 105 VPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE 164
V R ++V PP + + + T M V + C + G+P P+++W K A +
Sbjct: 2560 VGEAHRLYQVTVHVPPT-IADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGAR 2618
Query: 165 KLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDST 224
+ +R G L+I +P G + C ARN+AG +L V + +P + P
Sbjct: 2619 G-SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQA-SPVVKPLPSVVR 2676
Query: 225 VIDGMSVVLACETSGAPRPAITWQKGERILASG-SVQLPRFTPLESGSLLISPTHISDAG 283
+ V+L CE SG PRP ITWQK +A+G S Q+ L G L I+ DAG
Sbjct: 2677 AVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV-----LPGGQLRIAHASPEDAG 2731
Query: 284 TYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLR 343
Y C+A NS G LVV I D S +G+ A + C P I +
Sbjct: 2732 NYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK 2791
Query: 344 PGAPSGG 350
G P G
Sbjct: 2792 DGQPVSG 2798
Score = 113 bits (283), Expect = 3e-25
Identities = 91/301 (30%), Positives = 124/301 (41%), Gaps = 25/301 (8%)
Query: 61 IIWKKDGV---------LLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRG 111
+ W KDG L GG +RL I SD G Y C+ S+ VR
Sbjct: 1782 VTWYKDGQPLVLAQRTQALRGG-----QRLEIQEAQVSDKGLYSCKV---SNVAGEAVRT 1833
Query: 112 AYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQ 171
L+V PP F ++ + + C GVP P++TW KD VE +
Sbjct: 1834 FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVS 1893
Query: 172 RNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPL--DSTVIDGM 229
R G LQ+S L P G + C A N E + +AV +AP I + + V++G
Sbjct: 1894 RG-GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVL-VAPRIRSSGVAREHHVLEGQ 1951
Query: 230 SVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 289
V L CE G P P + W K L RF L+ GSL++ SDAG YTC+A
Sbjct: 1952 EVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY-LDGGSLVLKGLRASDAGAYTCVA 2010
Query: 290 TNSRGVDEASADLVVWARTRITKPPQDQSVI---KGTQASMVCGVTHDPRVTIRQLRPGA 346
N G D + V I + + G +MVC V P + + L+ G
Sbjct: 2011 HNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGL 2070
Query: 347 P 347
P
Sbjct: 2071 P 2071
Score = 110 bits (274), Expect = 3e-24
Identities = 91/296 (30%), Positives = 133/296 (44%), Gaps = 23/296 (7%)
Query: 60 HIIWKKDGVLLSGGISDH----NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLS 115
+I W KDG +SG + L + N G DAG Y C A ++V R +L+
Sbjct: 2786 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTA---ENAVGRARRRVHLT 2842
Query: 116 VLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG 175
+L P F P + + + + C A+G P P I W V +T DG
Sbjct: 2843 ILVLPVFTTLPGDR-SLRLGDRLWLRCAARGSPTPRIGW-----TVNDRPVTEGVSEQDG 2896
Query: 176 G--LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID--GMSV 231
G LQ + + +D+G + C+A N G Q +++ V AP + +G S +++ G S+
Sbjct: 2897 GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE-AP-VLQGEAFSYLVEPVGGSI 2954
Query: 232 VLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATN 291
L C G P P I W K L ++ L++GSL I T DAG Y CLA N
Sbjct: 2955 QLDCVVRGDPVPDIHWIKDGLPLRGSHLR----HQLQNGSLTIRRTERDDAGRYQCLAEN 3010
Query: 292 SRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAP 347
GV + LV+ + PQD +V G ++ C T +P TI L+ G P
Sbjct: 3011 EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQP 3066
Score = 104 bits (259), Expect = 2e-22
Identities = 88/303 (29%), Positives = 128/303 (42%), Gaps = 27/303 (8%)
Query: 61 IIWKKDGVLLSGG------ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 114
I W+KDG L G +S R L + + G Y CE S+ V + + L
Sbjct: 912 ISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCEC---SNVVGNSSQDLQL 968
Query: 115 SVLEPPQFV--KEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 172
V PPQ +EP ++ + V + C A G PPP++TW +D V E L Q
Sbjct: 969 EVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAE-LGLQLQN 1027
Query: 173 NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS----TVIDG 228
L + TG + C A N AG + L+V + P G LD T
Sbjct: 1028 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSV--LVPPELIGDLDPLTNITAALH 1085
Query: 229 MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGS--LLISPTHISDAGTYT 286
+ L CE G P PAI W +GE ++ G T L +G L ++ T D+G Y+
Sbjct: 1086 SPLTLLCEAMGIPPPAIRWFRGEEPVSPG-----EDTYLLAGGWMLKMTQTQEQDSGLYS 1140
Query: 287 CLATNSRGVDEASADLVVWARTRITKPPQDQ--SVIKGTQASMVCGVTHDPRVTIRQLRP 344
CLA+N G + + V I ++ V+ G A ++C VT P+ + +
Sbjct: 1141 CLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKD 1200
Query: 345 GAP 347
G P
Sbjct: 1201 GRP 1203
Score = 103 bits (258), Expect = 2e-22
Identities = 82/302 (27%), Positives = 135/302 (44%), Gaps = 25/302 (8%)
Query: 61 IIWKKDG----VLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
+ W++DG L + + + L + + G Y C A + R LSV
Sbjct: 1008 VTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVA---ENLAGRAERKFELSV 1064
Query: 117 LEPPQFVKE--PERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 174
L PP+ + + P +ITA + + + C+A G+PPP+I W++ V + T
Sbjct: 1065 LVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLA--- 1121
Query: 175 GG--LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDST--VIDGMS 230
GG L+++ D+G++ C A N AGE + + + V + P+I L+ V+DG +
Sbjct: 1122 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL-VPPSIENEDLEEVIKVLDGQT 1180
Query: 231 VVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLAT 290
L C +G P+P +TW K R LA G +P + L + ++S AG Y+C+A
Sbjct: 1181 AHLMCNVTGHPQPKLTWFKDGRPLARGDAH--HISP-DGVLLQVLQANLSSAGHYSCIAA 1237
Query: 291 NSRGVDEASADLVVWARTRITKPPQDQ-----SVIKGTQASMVCGVTHDPRVTIRQLRPG 345
N+ G L V I +D +V S++C P I ++ G
Sbjct: 1238 NAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDG 1297
Query: 346 AP 347
AP
Sbjct: 1298 AP 1299
Score = 102 bits (254), Expect = 6e-22
Identities = 89/305 (29%), Positives = 128/305 (41%), Gaps = 32/305 (10%)
Query: 52 PTRPLIKLHIIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPS 107
P R +H+ W KDG+ L + L I +DAG + C A +S
Sbjct: 2054 PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVA---ASPAGV 2110
Query: 108 VVRGAYLSVLEPPQFVKEP---ERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE 164
R L V PP V EP + + +V++PC+A+GVP P ++W KD E
Sbjct: 2111 ADRNFTLQVQVPP--VLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDG-----E 2163
Query: 165 KLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI--TRGPLD 222
L LQ+ + D+G + C A + AGE + L V P+I + P +
Sbjct: 2164 PLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME-PPHIEDSGQPTE 2222
Query: 223 STVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDA 282
++ G + L C+ G P+P ITW K + L T LE+ S + DA
Sbjct: 2223 LSLTPGAPMELLCDAQGTPQPNITWHKDGQAL----------TRLENNSRATRVLRVRDA 2272
Query: 283 GTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMV--CGVTHDPRVTIR 340
G YTCLA + G E S + V A I P + V+ +V C V +P I
Sbjct: 2273 GLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT 2332
Query: 341 QLRPG 345
R G
Sbjct: 2333 WHRDG 2337
Score = 101 bits (252), Expect = 1e-21
Identities = 91/325 (28%), Positives = 134/325 (41%), Gaps = 22/325 (6%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I W ++G+ S + + + L + +DA Y C A ++ S + L V
Sbjct: 1595 ISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT---LRV 1651
Query: 117 LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
PP+ +TA + V +PC P P +TWYKD+ + + + F
Sbjct: 1652 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEV-FLLPGTHT 1710
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAP---NITRGPLDSTVID-GMSVV 232
LQ+ D+GM+ C A NAAG Q L+V + P RGP D+ ++ G V
Sbjct: 1711 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVL-VPPAFRQAPRGPQDAVLVRVGDKAV 1769
Query: 233 LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATN 291
L+CET P P +TW K + L V R L G L I +SD G Y+C +N
Sbjct: 1770 LSCETDALPEPTVTWYKDGQPL----VLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSN 1825
Query: 292 SRGVDEASADLVVWARTRITKPPQDQ-SVIKGTQASMVCGVTHDPRVTIRQLRPGAP--- 347
G + L V P + S + G+ + C V+ P T+ L+ P
Sbjct: 1826 VAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 1885
Query: 348 SGGHWTYDSLYSHPQMRLRGAQVGT 372
S H RL+ AQ GT
Sbjct: 1886 SAVHGVVSRGGRLQLSRLQPAQAGT 1910
Score = 100 bits (248), Expect = 3e-21
Identities = 85/299 (28%), Positives = 128/299 (42%), Gaps = 17/299 (5%)
Query: 61 IIWKKDGVLLSGG------ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 114
++W KDG +S + R LT+ + SD+G Y C AV S+V + L
Sbjct: 727 LMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV---SAVGEDRQDVVL 783
Query: 115 SVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 174
V PP + E E +++ + V + CQ+ +PPP ++W+KD +E +
Sbjct: 784 QVHMPPSILGE-ELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHL-SADK 841
Query: 175 GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLA 234
LQ+ D G + C A N AG + L V R TV +G L+
Sbjct: 842 ALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLS 901
Query: 235 CETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSR 293
CE G P P I+W+K + L L + + G LL + ++ GTYTC +N
Sbjct: 902 CECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV--GRLLYLGQAQLAQEGTYTCECSNVV 959
Query: 294 GVDEASADLVVWARTRIT---KPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSG 349
G L V +I +PP SV++ A++ C T P T+ R G P G
Sbjct: 960 GNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVG 1018
Score = 98.6 bits (244), Expect = 9e-21
Identities = 77/245 (31%), Positives = 106/245 (43%), Gaps = 14/245 (5%)
Query: 63 WKKDGVLLSGGISDHNRRLTIPNPTGS--DAGYYECEAVLRSSSVPSVVRGAYLSVLEPP 120
W + ++ G+S+ + T+ S D+G Y C A R +V +++ V E P
Sbjct: 2880 WTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAV---SFVHVKEAP 2936
Query: 121 QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQIS 180
E ++ + + + C +G P P I W KD + L Q +G L I
Sbjct: 2937 VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH--QLQNGSLTIR 2994
Query: 181 GLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGA 240
DD G +QC A N G + L + S AP P D TV G V L C+ +G
Sbjct: 2995 RTERDDAGRYQCLAENEMGVAKKVVILVLQS-APVFQVEPQDMTVRSGDDVALRCQATGE 3053
Query: 241 PRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEAS 299
P P I W Q G+ + AS R L GSL + DAGTY C+A N G A
Sbjct: 3054 PTPTIEWLQAGQPLRASR-----RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 3108
Query: 300 ADLVV 304
A LVV
Sbjct: 3109 AFLVV 3113
Score = 97.8 bits (242), Expect = 2e-20
Identities = 77/297 (25%), Positives = 127/297 (42%), Gaps = 19/297 (6%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I W +DG++L + R L + + +D+G Y C A + S R + +
Sbjct: 2331 ITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR---VEI 2387
Query: 117 LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
P P + + + +PCQA GVP P ++W KD ++ + RF +G
Sbjct: 2388 HTVPTIRSGPPA-VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD-PRSPRFEILPEGS 2445
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACE 236
L+I ++ D G + C A N+AG + L V P I P + T+ +L CE
Sbjct: 2446 LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE-PPAIAPSPSNLTLTAHTPALLPCE 2504
Query: 237 TSGAPRPAITWQK-GERI---LASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 292
SG+P+P + W K G+++ L G+ +L L S +LL++ D+ + C+ +N
Sbjct: 2505 ASGSPKPLVVWWKDGQKLDFRLQQGAYRL-----LPSNALLLTAPGPQDSAQFECVVSNE 2559
Query: 293 RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSG 349
G + V I D +V + C T P T+ + GA G
Sbjct: 2560 VGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLG 2616
Score = 97.1 bits (240), Expect = 3e-20
Identities = 83/276 (30%), Positives = 124/276 (44%), Gaps = 33/276 (11%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
+ W KDG L+ G IS L + S AG+Y C A +++V + LSV
Sbjct: 1195 LTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIA---ANAVGEKTKHFQLSV 1251
Query: 117 LEPPQFVKEPE----RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 172
L P + E +T + + + C+A P P+ITW KD A E + +
Sbjct: 1252 LLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPG 1311
Query: 173 NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG-PLDSTVIDGM-- 229
G LQI +D G + C N GE + ++ V I P+I++ PL + +
Sbjct: 1312 THG-LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IPPSISKDDPLAEVGVKEVKT 1369
Query: 230 ----SVVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLL-ISPTHISDAG 283
++ L CE+ P P I W K G+ + S +Q+ L G LL I PT +SD+G
Sbjct: 1370 KVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQV-----LGEGRLLQIQPTQVSDSG 1424
Query: 284 TYTCLATNSRGVDEASADLVVWARTRITKPPQDQSV 319
Y C+ATN G D+ +++ I PP Q V
Sbjct: 1425 RYLCVATNVAGEDDQDFNVL------IQVPPMFQKV 1454
Score = 90.5 bits (223), Expect = 2e-18
Identities = 59/172 (34%), Positives = 84/172 (48%), Gaps = 5/172 (2%)
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACE 236
LQI + D G++ C A N AGE + L V + PNI GP++ V++ SV L C
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECL 626
Query: 237 TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 296
SG P P ++W KG + ++S + ++ L I +SDAG+Y C+A+N G
Sbjct: 627 ASGVPPPDVSWFKGHQPVSS---WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 683
Query: 297 EASADLVVWARTRITKPPQ-DQSVIKGTQASMVCGVTHDPRVTIRQLRPGAP 347
E L V RIT PP V+ T + C T P T+ L+ G P
Sbjct: 684 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP 735
Score = 89.7 bits (221), Expect = 4e-18
Identities = 87/327 (26%), Positives = 136/327 (41%), Gaps = 35/327 (10%)
Query: 63 WKKDGV-LLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL 117
W KD +L GG + + + L I D G Y+C A S R L V
Sbjct: 160 WTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAF---SPAGQQARDFQLRVH 216
Query: 118 EPPQFVKEPERHITAEMEK-VVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 176
PP E A ME +V + C+A+GVP P+ITW+KD A++ + R
Sbjct: 217 APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY-TRGGRQ 275
Query: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG---PLDSTVIDGMSVVL 233
LQ+ D G++ C A NA G + +T L V + P I P + G V L
Sbjct: 276 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVPPTIEGAGGRPYVVKAVAGRPVAL 334
Query: 234 ACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 292
C G P P ++W +G + S +L + L + + +G Y+C+A++
Sbjct: 335 ECVARGHPSPTLSWHHEGLPVAESNESRL----ETDGSVLRLESPGEASSGLYSCVASSP 390
Query: 293 RG--VDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGG 350
G V + S ++ V + + + + I G + C + P TI+ L+ G P+
Sbjct: 391 AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPA-- 448
Query: 351 HWTYDSLYSHPQMRLRGAQVGTRGSRL 377
L G QV ++G+ L
Sbjct: 449 ------------EELAGVQVASQGTTL 463
Score = 84.7 bits (208), Expect = 1e-16
Identities = 78/298 (26%), Positives = 122/298 (40%), Gaps = 26/298 (8%)
Query: 61 IIWKKDGVLLSGGISDHNR------RLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 114
+ W KDG L + H R L + SDAG Y C A + R +
Sbjct: 1967 VAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVA---HNPAGEDARLHTV 2023
Query: 115 SVLEPPQFVKEPERH--ITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 172
+VL PP + + + + ++V + C +G PP ++W KD + + + T
Sbjct: 2024 NVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRT-LLHG 2082
Query: 173 NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI--TRGPLDSTVIDGMS 230
+ L+IS + D G+F C A + AG + L V + P + D V+ G
Sbjct: 2083 SGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV-QVPPVLEPVEFQNDVVVVRGSL 2141
Query: 231 VVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 289
V L CE G P P ++W K GE +L+ Q P SL + D+GTY+C+A
Sbjct: 2142 VELPCEARGVPLPLVSWMKDGEPLLSQSLEQGP--------SLQLEAVGAGDSGTYSCVA 2193
Query: 290 TNSRGVDEASADLVVWARTRI--TKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPG 345
+ G L V I + P + S+ G ++C P+ I + G
Sbjct: 2194 VSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 2251
Score = 83.6 bits (205), Expect = 3e-16
Identities = 74/261 (28%), Positives = 105/261 (40%), Gaps = 12/261 (4%)
Query: 90 DAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPP 149
D G Y C A ++ R L VL PP P E V + C A GVPP
Sbjct: 577 DEGIYTCAA---TNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVT-LECLASGVPP 632
Query: 150 PSITWYKDAAVVEVEKLTRFRQRNDGG-LQISGLVPDDTGMFQCFARNAAGEVQTSTYLA 208
P ++W+K V DG L+I D G ++C A N AG + L
Sbjct: 633 PDVSWFKGHQ--PVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLR 690
Query: 209 VTSIAPNITRGP-LDSTVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQLPRFTP 266
V ++ P IT P L V+ V L C +GAP P + W K G + +G+ L F
Sbjct: 691 V-NVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFP- 748
Query: 267 LESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQAS 326
L ++ SD+G Y+C+A ++ G D L V I + SV+ +
Sbjct: 749 -GGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVA 807
Query: 327 MVCGVTHDPRVTIRQLRPGAP 347
+ C P + + G P
Sbjct: 808 LECQSHAMPPPVLSWWKDGRP 828
Score = 83.2 bits (204), Expect = 4e-16
Identities = 72/260 (27%), Positives = 111/260 (42%), Gaps = 23/260 (8%)
Query: 60 HIIWKKDGVLLSGGI----SDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLS 115
+I W KDG LL + R+L + SDAG Y C+A S++V + + L
Sbjct: 251 NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKA---SNAVGAAEKATRLD 307
Query: 116 VLEPPQFVKEPERH--ITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN 173
V PP R + A + V + C A+G P P+++W+ + + V + R
Sbjct: 308 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG--LPVAESNESRLET 365
Query: 174 DGG-LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPN--ITRGPLDSTVIDGMS 230
DG L++ +G++ C A + AGE Y + P + G T I G
Sbjct: 366 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQ-YSVEVQVPPQLLVAEGLGQVTTIVGQP 424
Query: 231 VVLACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 289
+ L C+ SG+P P I W Q G VQ+ + +L I + +G + C A
Sbjct: 425 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVAS----QGTTLHIDHVELDHSGLFACQA 480
Query: 290 TNSRGVDEASADLVV---WA 306
TN G A ++ V WA
Sbjct: 481 TNEAGTAGAEVEVSVHGEWA 500
Score = 82.4 bits (202), Expect = 7e-16
Identities = 84/315 (26%), Positives = 123/315 (39%), Gaps = 38/315 (12%)
Query: 61 IIWKKDGVLLS-----------------GG--ISDHNRRLTIPNPTGSDAGYYECEAVLR 101
I+W KD L+ GG + D + L P D+G Y C A
Sbjct: 50 IVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRA--- 106
Query: 102 SSSVPSVVRGAYLSVLEPPQFV-KEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAV 160
+ + R +L VL PP + + + V++ C GVP P + W KD
Sbjct: 107 ENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQP 166
Query: 161 VEVEKLTRFRQRNDGG-LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG 219
V + + + DG L+I+G D G +QC A + AG+ L V AP G
Sbjct: 167 V-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVH--APPTIWG 223
Query: 220 PLDS---TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESG-SLLIS 275
++ V++ V L CE G P P ITW K +L + + + G L +
Sbjct: 224 SNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST----KVVYTRGGRQLQLG 279
Query: 276 PTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKP---PQDQSVIKGTQASMVCGVT 332
SDAG YTC A+N+ G E + L V+ I P + G ++ C
Sbjct: 280 RAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVAR 339
Query: 333 HDPRVTIRQLRPGAP 347
P T+ G P
Sbjct: 340 GHPSPTLSWHHEGLP 354
Score = 81.6 bits (200), Expect = 1e-15
Identities = 73/238 (30%), Positives = 99/238 (41%), Gaps = 18/238 (7%)
Query: 74 ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY-LSVLEPPQFVKEPERHITA 132
+S R L I SDAG Y C A S+V Y L V PP+ P
Sbjct: 652 VSVDGRVLRIEQAQLSDAGSYRCVA----SNVAGSTELRYGLRVNVPPRITLPPSLPGPV 707
Query: 133 EMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG--LQISGLVPDDTGMF 190
+ V + C A G P P++ W KD V T Q GG L ++ D+G +
Sbjct: 708 LVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAG-TPGLQVFPGGRVLTLASARASDSGRY 766
Query: 191 QCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKG 250
C A +A GE + L V + P+I L+ +V+ SV L C++ P P ++W K
Sbjct: 767 SCVAVSAVGEDRQDVVLQV-HMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKD 825
Query: 251 ERILASGSVQLPR---FTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW 305
R L PR + L + + DAG YTC A N G E +L VW
Sbjct: 826 GRPLE------PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVW 877
Score = 75.1 bits (183), Expect = 1e-13
Identities = 63/247 (25%), Positives = 102/247 (41%), Gaps = 23/247 (9%)
Query: 120 PQFVKEPER--HITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE------------- 164
P ++E R +++ + + + C A G P P I W KDA +V V
Sbjct: 16 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75
Query: 165 KLTRFRQRNDG-GLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS 223
++ R ++G L + D+G++ C A N AG Q +L V + + G
Sbjct: 76 QVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQE 135
Query: 224 TV-IDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISD 281
+ + G V L C TSG P P + W K + + G P E G +L I+ +H+ D
Sbjct: 136 VLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGG---PHLQVQEDGQVLRITGSHVGD 192
Query: 282 AGTYTCLATNSRGVDEASADLVVWARTRI--TKPPQDQSVIKGTQASMVCGVTHDPRVTI 339
G Y C+A + G L V A I + + +V++ ++C P I
Sbjct: 193 EGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI 252
Query: 340 RQLRPGA 346
+ GA
Sbjct: 253 TWFKDGA 259
Score = 72.0 bits (175), Expect = 9e-13
Identities = 86/307 (28%), Positives = 122/307 (39%), Gaps = 44/307 (14%)
Query: 61 IIWKKDGVLLSGG----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSS----------VP 106
I W KDG ++ + R L I SD+G Y C A + VP
Sbjct: 1389 IRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVP 1448
Query: 107 SVVR--GAYLSVLEPPQFVKEPERHITAEMEKVVDIP----CQAKGVPPPSITWYKD--- 157
+ + G + + E +E +T E V + P C +PPP +TWY++
Sbjct: 1449 PMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQP 1508
Query: 158 -AAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI 216
+A EV L R LQI + ++ G + C A N GE L V + P +
Sbjct: 1509 LSAGDEVSVLQGGRV-----LQIPLVRAENAGRYSCKASNEVGEDWLHYELLV--LTPPV 1561
Query: 217 TRGPLDS-----TVIDGMSVVLACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESG 270
G + TV +V L C G P P I+W Q G S PR LE G
Sbjct: 1562 ILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPS-----PRLQVLEDG 1616
Query: 271 SLL-ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQ-SVIKGTQASMV 328
+L +S ++DA +Y C+A N G E L V RI +Q + I + S+
Sbjct: 1617 QVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLP 1676
Query: 329 CGVTHDP 335
C V P
Sbjct: 1677 CDVHAHP 1683
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 117 bits (292), Expect = 2e-26
Identities = 85/287 (29%), Positives = 131/287 (45%), Gaps = 25/287 (8%)
Query: 61 IIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPP 120
I W+K LS + L IP+ + D G YECEA +S V+G + +P
Sbjct: 271 IKWRKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEA--ENSKGRDTVQGRIIVQAQPE 328
Query: 121 --QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKD----AAVVEVEKLTRFRQRND 174
+ + + E I + + C A G P P++ W ++ A+ VE L
Sbjct: 329 WLKVISDTEADIGSNLRW----GCAAAGKPRPTVRWLRNGEPLASQNRVEVLA------- 377
Query: 175 GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTV--IDGMSVV 232
G L+ S L +D+GM+QC A N G + S LAV ++AP+ P+ + G ++
Sbjct: 378 GDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEIL 437
Query: 233 LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 292
+ C+ AP+ + W KG IL + S R T G+L+I SD G YTC A N
Sbjct: 438 IPCQPRAAPKAVVLWSKGTEILVNSS----RVTVTPDGTLIIRNISRSDEGKYTCFAENF 493
Query: 293 RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTI 339
G ++ L V T+IT P + G ++ C +HDP + +
Sbjct: 494 MGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDL 540
Score = 81.3 bits (199), Expect = 1e-15
Identities = 83/282 (29%), Positives = 113/282 (40%), Gaps = 25/282 (8%)
Query: 81 LTIPNPT-GSDAGYYECEAVLRSSSVPSVV-RGAYLSVLEPPQFVKEPERHITAEMEKVV 138
L I NPT DAG Y+C L S+ V +VV R A L +F KE + A V
Sbjct: 95 LVIMNPTKAQDAGVYQC---LASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGV 151
Query: 139 DIPCQAKG-VPPPSITWYKDAAVVEVEKLTR-FRQRNDGGLQISGLVPDDTGMFQCFARN 196
+PC P S W + + R F + G L I+ D G + C A +
Sbjct: 152 MLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATS 211
Query: 197 AAGEVQTSTYLAVTSI----------APNI-TRGPLDSTVIDGMSVVLACETSGAPRPAI 245
S + + AP+I R P ++ + G V L C G P P I
Sbjct: 212 HMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRI 271
Query: 246 TWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW 305
W+K + L+ P++T E +L I D GTY C A NS+G D ++V
Sbjct: 272 KWRKVDGSLS------PQWTTAEP-TLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQ 324
Query: 306 ARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAP 347
A+ K D G+ C PR T+R LR G P
Sbjct: 325 AQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEP 366
Score = 60.8 bits (146), Expect = 2e-09
Identities = 68/274 (24%), Positives = 104/274 (37%), Gaps = 25/274 (9%)
Query: 45 WKIRPQGPTRPLIKLHIIWKKDGVLLSGGISDHNR------RLTIPNPTGSDAGYYECEA 98
W G RP ++ W ++G L+ NR L + D+G Y+C A
Sbjct: 346 WGCAAAGKPRPTVR----WLRNGEPLAS----QNRVEVLAGDLRFSKLSLEDSGMYQCVA 397
Query: 99 VLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDA 158
+ ++ + A + L P + R I A + IPCQ + P + W K
Sbjct: 398 ENKHGTIYASAELA-VQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGT 456
Query: 159 AVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITR 218
++ +R DG L I + D G + CFA N G+ ++ L+V A IT
Sbjct: 457 EILV--NSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRD-ATKITL 513
Query: 219 GPLDSTVIDGMSVVLACETSGAPRPAIT--WQKGERIL---ASGSVQLPRFTPLESGSLL 273
P + + G ++ L C S P +T W + + G G L
Sbjct: 514 APSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLT 573
Query: 274 ISPTHISDAGTYTCLATNSRGVDEASADLVVWAR 307
I + G YTC+A VD AS + V R
Sbjct: 574 ILNAQLRHGGKYTCMAQTV--VDSASKEATVLVR 605
Score = 55.8 bits (133), Expect = 7e-08
Identities = 56/240 (23%), Positives = 101/240 (42%), Gaps = 29/240 (12%)
Query: 135 EKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFA 194
E+ V + C+A+ PP + W + +++E +R + + ++ D G++QC A
Sbjct: 54 EEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLA 113
Query: 195 RNAAGEVQTSTYLAVTSIAPNITRGPLDST-VIDGMSVVLACETSGAPRPAITWQKGERI 253
N G V + + ++ D +G V+L C A P +++ R
Sbjct: 114 SNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPP-AHYPGLSY----RW 168
Query: 254 LASGSVQLPRFTPLE--------SGSLLISPTHISDAGTYTCLAT-----NSRGVDEASA 300
L + + P F P + +G+L I+ T+ SD G Y+CLAT +++ V A
Sbjct: 169 LLN---EFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFA 225
Query: 301 DLVVWAR-TRITKP------PQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGGHWT 353
L + A TR+ P P + + G Q ++ C +P I+ + WT
Sbjct: 226 QLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWT 285
>gi|28373126 contactin 4 isoform c precursor [Homo sapiens]
Length = 698
Score = 116 bits (291), Expect = 3e-26
Identities = 75/209 (35%), Positives = 106/209 (50%), Gaps = 11/209 (5%)
Query: 134 MEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFR-QRNDGGLQISGLVPDDTGMFQC 192
ME+ V C+A G P P+ W K+ + LTR R Q G L I+ + D GM+QC
Sbjct: 1 MEENVFWECKANGRPKPTYKWLKNGEPL----LTRDRIQIEQGTLNITIVNLSDAGMYQC 56
Query: 193 FARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID--GMSVVLACETSGAPRPAITWQKG 250
A N G + ++ L+V ++ P+ +R L + G VV+ C+ +P+P TW+KG
Sbjct: 57 LAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKG 116
Query: 251 ERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRI 310
IL R T E G+L I SDAG+YTC+ATN G ++ +LVV TR+
Sbjct: 117 RDILKENE----RITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRV 172
Query: 311 TKPPQDQSVIKGTQASMVCGVTHDPRVTI 339
PP V G + C VTHD + I
Sbjct: 173 MVPPSSMDVTVGESIVLPCQVTHDHSLDI 201
Score = 68.2 bits (165), Expect = 1e-11
Identities = 73/269 (27%), Positives = 109/269 (40%), Gaps = 19/269 (7%)
Query: 45 WKIRPQGPTRPLIKLHIIWKKDG--VLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRS 102
W+ + G +P K W K+G +L I L I SDAG Y+C A +
Sbjct: 7 WECKANGRPKPTYK----WLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKH 62
Query: 103 SSVPSVVRGAYLSVLEP-PQFVKEPERHIT-AEMEKVVDIPCQAKGVPPPSITWYKDAAV 160
+ S A LSV+ P F + + +T ++ V I C+ K P P TW K +
Sbjct: 63 GVIFS---NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDI 119
Query: 161 VEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGP 220
++ + R DG L+I + D G + C A N G ++ L V + P
Sbjct: 120 LKENE--RITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD-PTRVMVPP 176
Query: 221 LDSTVIDGMSVVLACETSGAPRPAI--TWQKGERILA--SGSVQLPRFTPLES-GSLLIS 275
V G S+VL C+ + I TW ++ R +S G L+I
Sbjct: 177 SSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIR 236
Query: 276 PTHISDAGTYTCLATNSRGVDEASADLVV 304
+ AG Y C+ S A+ADL+V
Sbjct: 237 NIQLKHAGKYVCMVQTSVDRLSAAADLIV 265
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 116 bits (290), Expect = 4e-26
Identities = 94/309 (30%), Positives = 145/309 (46%), Gaps = 28/309 (9%)
Query: 55 PLIKLHIIWKKDGVLLSGGISDHNRRLT-----IPNPTGS-----DAGYYECEAVLRSSS 104
P+IK WKKDG+ L+ G+ + ++L+ I N S D G Y+CEA L S
Sbjct: 70 PVIK----WKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSG 125
Query: 105 VPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA-VVEV 163
+ R A ++V P +F+ + E +TA M V + C+ G P P+I W K+ + +
Sbjct: 126 -SIISRTAKVAVAGPLRFLSQTES-VTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPI 183
Query: 164 EKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIA-PNITRG--- 219
+R G LQIS L P D G+++C ARN A +T V ++ P + R
Sbjct: 184 PGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASS-RTGNEAEVRILSDPGLHRQLYF 242
Query: 220 ---PLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISP 276
P + I+G VL C SG P P+ TW +GE ++ ++ +++ L +LLIS
Sbjct: 243 LQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVI---QLRSKKYSLLGGSNLLISN 299
Query: 277 THISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPR 336
D+G YTC+ T ASA+L V P + + C V+ P
Sbjct: 300 VTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPV 359
Query: 337 VTIRQLRPG 345
T+ ++ G
Sbjct: 360 PTVNWMKNG 368
Score = 83.6 bits (205), Expect = 3e-16
Identities = 74/274 (27%), Positives = 108/274 (39%), Gaps = 28/274 (10%)
Query: 80 RLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVD 139
R + NP S G EA +R S P + R Y F++ P + E + V
Sbjct: 211 RCSARNPASSRTGN---EAEVRILSDPGLHRQLY--------FLQRPSNVVAIEGKDAV- 258
Query: 140 IPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAG 199
+ C G PPPS TW + V+++ ++ L IS + DD+GM+ C
Sbjct: 259 LECCVSGYPPPSFTWLRGEEVIQLRS-KKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNE 317
Query: 200 EVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSV 259
+ S L V + P P + + M + C SG P P + W K +G V
Sbjct: 318 NISASAELTVL-VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMK------NGDV 370
Query: 260 QLPR--FTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQ 317
+P F + +L I SD G Y C+A N G + SA L+V KP
Sbjct: 371 VIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV------PKPAIPS 424
Query: 318 SVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGGH 351
S + + V V R RP A + G+
Sbjct: 425 SSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGN 458
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 115 bits (289), Expect = 5e-26
Identities = 101/317 (31%), Positives = 143/317 (45%), Gaps = 27/317 (8%)
Query: 45 WKIRPQGPTRPLIKLHIIWKKDGVLLSGGISD--HNRRLTIPNPTGSDAGYYECEAVLRS 102
++ + QG +P ++ WKKD L G D + L I +D G Y C A R
Sbjct: 260 FRCQVQGDPQPTVR----WKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENR- 314
Query: 103 SSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVE 162
V + A L+V PPQFV P I A+ + V PC+ KG P P++ W K+ +
Sbjct: 315 --VGKMEASATLTVRAPPQFVVRPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNL 371
Query: 163 V------EKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIA--- 213
+ + +R G L I+ + D G + C A AG + L VT +
Sbjct: 372 LFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDR 431
Query: 214 --PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGS 271
P I +GP + T+ + +L C+ +G P P I+W K E G + PR T E G+
Sbjct: 432 PPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLK-EGFTFPG--RDPRATIQEQGT 488
Query: 272 LLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQAS-MVCG 330
L I ISD GTYTC+AT+S G SA L V D S + G + V
Sbjct: 489 LQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTD 548
Query: 331 VTHDPRVTIRQLRPGAP 347
VT + VT+ +PG P
Sbjct: 549 VTKN-SVTL-SWQPGTP 563
Score = 103 bits (256), Expect = 4e-22
Identities = 87/301 (28%), Positives = 130/301 (43%), Gaps = 25/301 (8%)
Query: 61 IIWKKDGVLLSGGISD-HNRRLTIPNPT------------GSDAGYYECEAVLRSSSVPS 107
I W KDG + D + R+ +P+ + D G Y C V R+ +
Sbjct: 78 IEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVC--VARNYLGEA 135
Query: 108 VVRGAYLSV-LEPPQFVKEPERHITAEMEKVVDIPCQA-KGVPPPSITWYKDAAVVEVEK 165
V R A L V L F + P + A E + + CQ +G P P+I W KD ++ +K
Sbjct: 136 VSRNASLEVALLRDDFRQNPTDVVVAAGEPAI-LECQPPRGHPEPTIYWKKDKVRID-DK 193
Query: 166 LTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTV 225
R R G L IS D GM+ C N GE + P R P++ V
Sbjct: 194 EERISIRG-GKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVV 252
Query: 226 IDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTY 285
++ +V C+ G P+P + W+K + L G R+ + +L I T +D GTY
Sbjct: 253 LEEEAVEFRCQVQGDPQPTVRWKKDDADLPRG-----RYDIKDDYTLRIKKTMSTDEGTY 307
Query: 286 TCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPG 345
C+A N G EASA L V A + P+DQ V +G + C +P+ + + G
Sbjct: 308 MCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEG 367
Query: 346 A 346
+
Sbjct: 368 S 368
Score = 102 bits (253), Expect = 8e-22
Identities = 75/233 (32%), Positives = 108/233 (46%), Gaps = 16/233 (6%)
Query: 119 PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR---NDG 175
PP+ V+ P I ++ E + C+A+G P P+I WYKD VE +K R G
Sbjct: 46 PPRIVEHPSDVIVSKGEPTT-LNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 104
Query: 176 GLQISGLV-----PDDTGMFQCFARNAAGE-VQTSTYLAVTSIAPNITRGPLDSTVIDGM 229
L +V D G + C ARN GE V + L V + + + P D V G
Sbjct: 105 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 164
Query: 230 SVVLACE-TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 288
+L C+ G P P I W+K + + ++ + G L+IS T SDAG YTC+
Sbjct: 165 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERI----SIRGGKLMISNTRKSDAGMYTCV 220
Query: 289 ATNSRGV-DEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIR 340
TN G D A+L V+ R + P +Q V++ C V DP+ T+R
Sbjct: 221 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVR 273
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 115 bits (289), Expect = 5e-26
Identities = 101/317 (31%), Positives = 143/317 (45%), Gaps = 27/317 (8%)
Query: 45 WKIRPQGPTRPLIKLHIIWKKDGVLLSGGISD--HNRRLTIPNPTGSDAGYYECEAVLRS 102
++ + QG +P ++ WKKD L G D + L I +D G Y C A R
Sbjct: 244 FRCQVQGDPQPTVR----WKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENR- 298
Query: 103 SSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVE 162
V + A L+V PPQFV P I A+ + V PC+ KG P P++ W K+ +
Sbjct: 299 --VGKMEASATLTVRAPPQFVVRPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNL 355
Query: 163 V------EKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIA--- 213
+ + +R G L I+ + D G + C A AG + L VT +
Sbjct: 356 LFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDR 415
Query: 214 --PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGS 271
P I +GP + T+ + +L C+ +G P P I+W K E G + PR T E G+
Sbjct: 416 PPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLK-EGFTFPG--RDPRATIQEQGT 472
Query: 272 LLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQAS-MVCG 330
L I ISD GTYTC+AT+S G SA L V D S + G + V
Sbjct: 473 LQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTD 532
Query: 331 VTHDPRVTIRQLRPGAP 347
VT + VT+ +PG P
Sbjct: 533 VTKN-SVTL-SWQPGTP 547
Score = 103 bits (256), Expect = 4e-22
Identities = 87/301 (28%), Positives = 130/301 (43%), Gaps = 25/301 (8%)
Query: 61 IIWKKDGVLLSGGISD-HNRRLTIPNPT------------GSDAGYYECEAVLRSSSVPS 107
I W KDG + D + R+ +P+ + D G Y C V R+ +
Sbjct: 62 IEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVC--VARNYLGEA 119
Query: 108 VVRGAYLSV-LEPPQFVKEPERHITAEMEKVVDIPCQA-KGVPPPSITWYKDAAVVEVEK 165
V R A L V L F + P + A E + + CQ +G P P+I W KD ++ +K
Sbjct: 120 VSRNASLEVALLRDDFRQNPTDVVVAAGEPAI-LECQPPRGHPEPTIYWKKDKVRID-DK 177
Query: 166 LTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTV 225
R R G L IS D GM+ C N GE + P R P++ V
Sbjct: 178 EERISIRG-GKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVV 236
Query: 226 IDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTY 285
++ +V C+ G P+P + W+K + L G R+ + +L I T +D GTY
Sbjct: 237 LEEEAVEFRCQVQGDPQPTVRWKKDDADLPRG-----RYDIKDDYTLRIKKTMSTDEGTY 291
Query: 286 TCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPG 345
C+A N G EASA L V A + P+DQ V +G + C +P+ + + G
Sbjct: 292 MCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEG 351
Query: 346 A 346
+
Sbjct: 352 S 352
Score = 102 bits (253), Expect = 8e-22
Identities = 75/233 (32%), Positives = 108/233 (46%), Gaps = 16/233 (6%)
Query: 119 PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR---NDG 175
PP+ V+ P I ++ E + C+A+G P P+I WYKD VE +K R G
Sbjct: 30 PPRIVEHPSDVIVSKGEPTT-LNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 88
Query: 176 GLQISGLV-----PDDTGMFQCFARNAAGE-VQTSTYLAVTSIAPNITRGPLDSTVIDGM 229
L +V D G + C ARN GE V + L V + + + P D V G
Sbjct: 89 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 148
Query: 230 SVVLACE-TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 288
+L C+ G P P I W+K + + ++ + G L+IS T SDAG YTC+
Sbjct: 149 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERI----SIRGGKLMISNTRKSDAGMYTCV 204
Query: 289 ATNSRGV-DEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIR 340
TN G D A+L V+ R + P +Q V++ C V DP+ T+R
Sbjct: 205 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVR 257
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 114 bits (286), Expect = 1e-25
Identities = 79/226 (34%), Positives = 114/226 (50%), Gaps = 15/226 (6%)
Query: 81 LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDI 140
L I N D+G Y C A ++++ SV A++ V PQF P+ + E + VD
Sbjct: 397 LYIQNVVQGDSGEYACSA---TNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQ-TVDF 452
Query: 141 PCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGE 200
C+AKG PPP I W K + + V++ R + G L+ISG+ D G ++C A N G
Sbjct: 453 QCEAKGNPPPVIAWTKGGSQLSVDR--RHLVLSSGTLRISGVALHDQGQYECQAVNIIGS 510
Query: 201 VQTSTYLAVTS-IAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK-GERILASGS 258
+ +L V + P P D+TV G +V L C + G P PAITW K G ++ SG
Sbjct: 511 QKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESG- 569
Query: 259 VQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVV 304
+F G L I+ +DAG Y C+A N+ G AS +V+
Sbjct: 570 ----KFHISPEGFLTINDVGPADAGRYECVARNTIG--SASVSMVL 609
Score = 108 bits (271), Expect = 7e-24
Identities = 75/251 (29%), Positives = 115/251 (45%), Gaps = 14/251 (5%)
Query: 106 PSVVRGAYLSVLEPPQFVKEPERHITAEME-------KVVDIPCQAKGVPPPSITWYKDA 158
P ++G ++ + P + E R IT+E + V C+A+G P P I W ++
Sbjct: 225 PRRIQGRSVATITPEELNCERPR-ITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNN 283
Query: 159 AVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLA---VTSIAPN 215
+ ++ +R +DG L I D G++QC A+N AGEV+T + P
Sbjct: 284 NELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPT 343
Query: 216 ITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLIS 275
P ++ V+ G SV L C +G P P I+W +G+R PR SG L I
Sbjct: 344 FVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVD---PRVNITPSGGLYIQ 400
Query: 276 PTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDP 335
D+G Y C ATN+ A+A ++V A + T PQD+ VI+G C +P
Sbjct: 401 NVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNP 460
Query: 336 RVTIRQLRPGA 346
I + G+
Sbjct: 461 PPVIAWTKGGS 471
Score = 107 bits (266), Expect = 2e-23
Identities = 92/307 (29%), Positives = 126/307 (41%), Gaps = 21/307 (6%)
Query: 48 RPQGPTRPLIKLHIIWKKDGVLLSGGISDH-----NRRLTIPNPTGSDAGYYECEAVLRS 102
R +G +P IIW ++ LS + L I N +D G Y+C A +
Sbjct: 268 RAEGNPKP----EIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVA 323
Query: 103 SSVPSV-VRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYK-DAAV 160
V + V Y P FV +P+ E V + C A G PPP I+W + D
Sbjct: 324 GEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVT-LECSATGHPPPRISWTRGDRTP 382
Query: 161 VEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGP 220
+ V+ R GGL I +V D+G + C A N V + ++ V ++ P T P
Sbjct: 383 LPVDP--RVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQAL-PQFTVTP 439
Query: 221 LDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHIS 280
D VI+G +V CE G P P I W KG L+ R L SG+L IS +
Sbjct: 440 QDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDR----RHLVLSSGTLRISGVALH 495
Query: 281 DAGTYTCLATNSRGVDEASADLVVWARTR--ITKPPQDQSVIKGTQASMVCGVTHDPRVT 338
D G Y C A N G + A L V R P D +V G + C +P
Sbjct: 496 DQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPA 555
Query: 339 IRQLRPG 345
I + G
Sbjct: 556 ITWNKDG 562
Score = 68.9 bits (167), Expect = 7e-12
Identities = 55/163 (33%), Positives = 77/163 (47%), Gaps = 13/163 (7%)
Query: 61 IIWKKDGVLLSGG---ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL 117
I W K G LS + + L I D G YEC+AV S V A+L+V
Sbjct: 464 IAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVV---AHLTVQ 520
Query: 118 E--PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG 175
P F P T E+ V +PC ++G P P+ITW KD V+V + +F +G
Sbjct: 521 PRVTPVFASIPS-DTTVEVGANVQLPCSSQGEPEPAITWNKDG--VQVTESGKFHISPEG 577
Query: 176 GLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITR 218
L I+ + P D G ++C ARN G S L+V P+++R
Sbjct: 578 FLTINDVGPADAGRYECVARNTIGSASVSMVLSVN--VPDVSR 618
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 112 bits (279), Expect = 8e-25
Identities = 89/307 (28%), Positives = 134/307 (43%), Gaps = 30/307 (9%)
Query: 45 WKIRPQGPTRPLIKLHIIWKKDGVLLSGGISD--HNRRLTIPNPTGSDAGYYECEAVLRS 102
+K +G P ++ W+KD L + + L I T D G Y C A
Sbjct: 242 FKCEARGDPVPTVR----WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA---E 294
Query: 103 SSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA--- 159
+ V A L+V EPP FV +P + A + + V C+A G P P+I W ++ +
Sbjct: 295 NMVGKAEASATLTVQEPPHFVVKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNL 353
Query: 160 ---VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIA--- 213
+ +RF G L I+ + D G + C N AG + T YL VT +
Sbjct: 354 LFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADR 413
Query: 214 --PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGS 271
P I +GP++ TV + VL+C +G+P P I W+K ++ S Q R LE+G
Sbjct: 414 PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLV---STQDSRIKQLENGV 470
Query: 272 LLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGV 331
L I + D G YTC+A+ G SA + V +PP + T +++
Sbjct: 471 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP------RPTDPNLIPSA 524
Query: 332 THDPRVT 338
P VT
Sbjct: 525 PSKPEVT 531
Score = 93.6 bits (231), Expect = 3e-19
Identities = 73/233 (31%), Positives = 104/233 (44%), Gaps = 16/233 (6%)
Query: 119 PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR---NDG 175
PP+ V+ P I ++ E + C+A+G P P+I WYK VE +K R G
Sbjct: 28 PPRIVEHPSDLIVSKGEPAT-LNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 176 GLQISGLV-----PDDTGMFQCFARNAAGE-VQTSTYLAVTSIAPNITRGPLDSTVIDGM 229
L +V D G++ C ARN GE V + L V + + + P D V G
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 230 SVVLACE-TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 288
V+ C+ G P P I+W+K L ++ + G L+I+ T SDAG Y C+
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERI----TIRGGKLMITYTRKSDAGKYVCV 202
Query: 289 ATNSRGVDEAS-ADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIR 340
TN G E+ A+L V R K P + +V A C DP T+R
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVR 255
Score = 89.4 bits (220), Expect = 5e-18
Identities = 76/259 (29%), Positives = 110/259 (42%), Gaps = 12/259 (4%)
Query: 90 DAGYYECEAVLRSSSVPSVVRGAYLSV-LEPPQFVKEPERHITAEMEKVVDIPCQA-KGV 147
D G Y C V R+ +V A L V + F + P + A E V + CQ +G
Sbjct: 102 DEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAV-MECQPPRGH 158
Query: 148 PPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYL 207
P P+I+W KD + ++ +K R R G L I+ D G + C N GE ++
Sbjct: 159 PEPTISWKKDGSPLD-DKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVAE 216
Query: 208 AVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPL 267
P+ + P + V S CE G P P + W+K + G + R+
Sbjct: 217 LTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD-----GELPKSRYEIR 271
Query: 268 ESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASM 327
+ +L I D G+YTC+A N G EASA L V P+DQ V G +
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTF 331
Query: 328 VCGVTHDPRVTIRQLRPGA 346
C T +P+ I R G+
Sbjct: 332 QCEATGNPQPAIFWRREGS 350
Score = 47.8 bits (112), Expect = 2e-05
Identities = 44/143 (30%), Positives = 52/143 (36%), Gaps = 9/143 (6%)
Query: 214 PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSL 272
P I P D V G L C+ G P P I W K GER+ L SGSL
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 273 LI-----SPTHISDAGTYTCLATNSRG--VDEASADLVVWARTRITKPPQDQSVIKGTQA 325
D G Y C+A N G V ++ V R + P D V G A
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 326 SMVCGVTH-DPRVTIRQLRPGAP 347
M C P TI + G+P
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSP 171
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 112 bits (279), Expect = 8e-25
Identities = 79/264 (29%), Positives = 124/264 (46%), Gaps = 14/264 (5%)
Query: 76 DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEME 135
+HN+ L + D G Y C L +S+ S Y++V P ++ +P+ H+ E
Sbjct: 287 NHNKTLQLLKVGEEDDGEYRC---LAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGE 343
Query: 136 KVVDIPCQAKGVPPPSITW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFA 194
+ CQ +G P P +TW V E+ K ++R + G L +S + P DT + QC A
Sbjct: 344 -TARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR-GALILSNVQPSDTMVTQCEA 401
Query: 195 RNAAGEVQTSTYLAVTSIAPNI-TRGPLDSTVIDGMSVVLACETSGAPRPAITW--QKGE 251
RN G + + Y+ V + I T + G + L C+ GAP P++ W + G
Sbjct: 402 RNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 461
Query: 252 RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRIT 311
+L Q RF P +G+L I +D G Y CLA N + A+L V T+IT
Sbjct: 462 TVL-----QDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQIT 516
Query: 312 KPPQDQSVIKGTQASMVCGVTHDP 335
+ P+ KG++ + C + DP
Sbjct: 517 QGPRSTIEKKGSRVTFTCQASFDP 540
Score = 83.2 bits (204), Expect = 4e-16
Identities = 76/281 (27%), Positives = 117/281 (41%), Gaps = 19/281 (6%)
Query: 32 PSEYPHGTSRGPLWKIRPQGPTRPLIKLHIIWKKDGVLLSGGISDHNRR-----LTIPNP 86
P + +G + QG +P + W+ +G+ + D R L + N
Sbjct: 334 PQSHLYGPGETARLDCQVQGRPQP----EVTWRINGIPVEELAKDQKYRIQRGALILSNV 389
Query: 87 TGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE-PPQFVKEPERHITAEMEKVVDIPCQAK 145
SD +CEA R + + AY+ V++ P + + + A + C+A
Sbjct: 390 QPSDTMVTQCEARNRHGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAF 446
Query: 146 GVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTST 205
G P PS+ W + ++ RF +G L I L +DTG + C A N V
Sbjct: 447 GAPVPSVQWLDEDGTTVLQD-ERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMA 505
Query: 206 YLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP--RPAITWQKGERILASGSVQLPR 263
L V A IT+GP + G V C+ S P +P+ITW+ R L
Sbjct: 506 NLKVKD-ATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKY 564
Query: 264 FTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVV 304
F +E G L+I SD G Y+C+A+ V E+ A L+V
Sbjct: 565 F--IEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV 603
Score = 72.0 bits (175), Expect = 9e-13
Identities = 57/224 (25%), Positives = 104/224 (46%), Gaps = 9/224 (4%)
Query: 122 FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISG 181
F H+ A + + + C A+G P P+I W + + + +++T Q ++ LQ+
Sbjct: 239 FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVT--YQNHNKTLQLLK 296
Query: 182 LVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP 241
+ +D G ++C A N+ G + + Y+ V + AP P G + L C+ G P
Sbjct: 297 VGEEDDGEYRCLAENSLGSARHAYYVTVEA-APYWLHKPQSHLYGPGETARLDCQVQGRP 355
Query: 242 RPAITWQ-KGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 300
+P +TW+ G + Q R ++ G+L++S SD C A N G+ A+A
Sbjct: 356 QPEVTWRINGIPVEELAKDQKYR---IQRGALILSNVQPSDTMVTQCEARNRHGLLLANA 412
Query: 301 DL-VVWARTRI-TKPPQDQSVIKGTQASMVCGVTHDPRVTIRQL 342
+ VV +I T Q ++G+ A ++C P +++ L
Sbjct: 413 YIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL 456
Score = 53.1 bits (126), Expect = 4e-07
Identities = 54/254 (21%), Positives = 98/254 (38%), Gaps = 24/254 (9%)
Query: 116 VLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEK---LTRFRQR 172
++EPP ++ R + + + C+A G P W +D + ++ +T ++
Sbjct: 26 LMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSP 85
Query: 173 NDGGLQISG----LVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDST-VID 227
+ G I+G G+++CFA N G + + AP + + V +
Sbjct: 86 HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE 145
Query: 228 GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISD------ 281
G SVVL C + P + +IL Q R T ++G+L + SD
Sbjct: 146 GESVVLPCNPPPSAEPLRIYWMNSKIL--HIKQDERVTMGQNGNLYFANVLTSDNHSDYI 203
Query: 282 -----AGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQS---VIKGTQASMVCGVTH 333
GT T + + + + ++ + R+ P S ++G + C
Sbjct: 204 CHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEG 263
Query: 334 DPRVTIRQLRPGAP 347
P TI+ LRP P
Sbjct: 264 FPTPTIKWLRPSGP 277
Score = 46.6 bits (109), Expect = 4e-05
Identities = 67/311 (21%), Positives = 111/311 (35%), Gaps = 33/311 (10%)
Query: 63 WKKDGVLLSG----GI----SDHNRRLTIPNPTGSDA----GYYECEAVLRSSSVPSVVR 110
W +DGV G+ S H+ TI + A G Y C A + + S
Sbjct: 64 WTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMS--H 121
Query: 111 GAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFR 170
L P++ KE + + E + V +PC P ++ ++ ++ +++ R
Sbjct: 122 EIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT 181
Query: 171 QRNDGGLQISG-LVPDDTGMFQCFA---------RNAAGEVQTSTYLAVTSIAPNI---T 217
+G L + L D+ + C A + +++ ++ P + T
Sbjct: 182 MGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPT 241
Query: 218 RGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFT-PLESGSLLISP 276
+ G +VL C G P P I W + SG + R T + +L +
Sbjct: 242 NSSSHLVALQGQPLVLECIAEGFPTPTIKWLR-----PSGPMPADRVTYQNHNKTLQLLK 296
Query: 277 THISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPR 336
D G Y CLA NS G + + V A PQ G A + C V P+
Sbjct: 297 VGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQ 356
Query: 337 VTIRQLRPGAP 347
+ G P
Sbjct: 357 PEVTWRINGIP 367
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 112 bits (279), Expect = 8e-25
Identities = 79/264 (29%), Positives = 124/264 (46%), Gaps = 14/264 (5%)
Query: 76 DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEME 135
+HN+ L + D G Y C L +S+ S Y++V P ++ +P+ H+ E
Sbjct: 292 NHNKTLQLLKVGEEDDGEYRC---LAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGE 348
Query: 136 KVVDIPCQAKGVPPPSITW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFA 194
+ CQ +G P P +TW V E+ K ++R + G L +S + P DT + QC A
Sbjct: 349 -TARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR-GALILSNVQPSDTMVTQCEA 406
Query: 195 RNAAGEVQTSTYLAVTSIAPNI-TRGPLDSTVIDGMSVVLACETSGAPRPAITW--QKGE 251
RN G + + Y+ V + I T + G + L C+ GAP P++ W + G
Sbjct: 407 RNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 466
Query: 252 RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRIT 311
+L Q RF P +G+L I +D G Y CLA N + A+L V T+IT
Sbjct: 467 TVL-----QDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQIT 521
Query: 312 KPPQDQSVIKGTQASMVCGVTHDP 335
+ P+ KG++ + C + DP
Sbjct: 522 QGPRSTIEKKGSRVTFTCQASFDP 545
Score = 83.2 bits (204), Expect = 4e-16
Identities = 76/281 (27%), Positives = 117/281 (41%), Gaps = 19/281 (6%)
Query: 32 PSEYPHGTSRGPLWKIRPQGPTRPLIKLHIIWKKDGVLLSGGISDHNRR-----LTIPNP 86
P + +G + QG +P + W+ +G+ + D R L + N
Sbjct: 339 PQSHLYGPGETARLDCQVQGRPQP----EVTWRINGIPVEELAKDQKYRIQRGALILSNV 394
Query: 87 TGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE-PPQFVKEPERHITAEMEKVVDIPCQAK 145
SD +CEA R + + AY+ V++ P + + + A + C+A
Sbjct: 395 QPSDTMVTQCEARNRHGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAF 451
Query: 146 GVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTST 205
G P PS+ W + ++ RF +G L I L +DTG + C A N V
Sbjct: 452 GAPVPSVQWLDEDGTTVLQD-ERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMA 510
Query: 206 YLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP--RPAITWQKGERILASGSVQLPR 263
L V A IT+GP + G V C+ S P +P+ITW+ R L
Sbjct: 511 NLKVKD-ATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKY 569
Query: 264 FTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVV 304
F +E G L+I SD G Y+C+A+ V E+ A L+V
Sbjct: 570 F--IEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV 608
Score = 72.0 bits (175), Expect = 9e-13
Identities = 57/224 (25%), Positives = 104/224 (46%), Gaps = 9/224 (4%)
Query: 122 FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISG 181
F H+ A + + + C A+G P P+I W + + + +++T Q ++ LQ+
Sbjct: 244 FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVT--YQNHNKTLQLLK 301
Query: 182 LVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP 241
+ +D G ++C A N+ G + + Y+ V + AP P G + L C+ G P
Sbjct: 302 VGEEDDGEYRCLAENSLGSARHAYYVTVEA-APYWLHKPQSHLYGPGETARLDCQVQGRP 360
Query: 242 RPAITWQ-KGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 300
+P +TW+ G + Q R ++ G+L++S SD C A N G+ A+A
Sbjct: 361 QPEVTWRINGIPVEELAKDQKYR---IQRGALILSNVQPSDTMVTQCEARNRHGLLLANA 417
Query: 301 DL-VVWARTRI-TKPPQDQSVIKGTQASMVCGVTHDPRVTIRQL 342
+ VV +I T Q ++G+ A ++C P +++ L
Sbjct: 418 YIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL 461
Score = 54.3 bits (129), Expect = 2e-07
Identities = 55/254 (21%), Positives = 98/254 (38%), Gaps = 24/254 (9%)
Query: 116 VLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEK---LTRFRQR 172
V+EPP ++ R + + + C+A G P W +D + ++ +T ++
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSP 90
Query: 173 NDGGLQISG----LVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDST-VID 227
+ G I+G G+++CFA N G + + AP + + V +
Sbjct: 91 HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE 150
Query: 228 GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISD------ 281
G SVVL C + P + +IL Q R T ++G+L + SD
Sbjct: 151 GESVVLPCNPPPSAEPLRIYWMNSKIL--HIKQDERVTMGQNGNLYFANVLTSDNHSDYI 208
Query: 282 -----AGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQS---VIKGTQASMVCGVTH 333
GT T + + + + ++ + R+ P S ++G + C
Sbjct: 209 CHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEG 268
Query: 334 DPRVTIRQLRPGAP 347
P TI+ LRP P
Sbjct: 269 FPTPTIKWLRPSGP 282
Score = 46.6 bits (109), Expect = 4e-05
Identities = 67/311 (21%), Positives = 111/311 (35%), Gaps = 33/311 (10%)
Query: 63 WKKDGVLLSG----GI----SDHNRRLTIPNPTGSDA----GYYECEAVLRSSSVPSVVR 110
W +DGV G+ S H+ TI + A G Y C A + + S
Sbjct: 69 WTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMS--H 126
Query: 111 GAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFR 170
L P++ KE + + E + V +PC P ++ ++ ++ +++ R
Sbjct: 127 EIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT 186
Query: 171 QRNDGGLQISG-LVPDDTGMFQCFA---------RNAAGEVQTSTYLAVTSIAPNI---T 217
+G L + L D+ + C A + +++ ++ P + T
Sbjct: 187 MGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPT 246
Query: 218 RGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFT-PLESGSLLISP 276
+ G +VL C G P P I W + SG + R T + +L +
Sbjct: 247 NSSSHLVALQGQPLVLECIAEGFPTPTIKWLR-----PSGPMPADRVTYQNHNKTLQLLK 301
Query: 277 THISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPR 336
D G Y CLA NS G + + V A PQ G A + C V P+
Sbjct: 302 VGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQ 361
Query: 337 VTIRQLRPGAP 347
+ G P
Sbjct: 362 PEVTWRINGIP 372
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 112 bits (279), Expect = 8e-25
Identities = 79/264 (29%), Positives = 124/264 (46%), Gaps = 14/264 (5%)
Query: 76 DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEME 135
+HN+ L + D G Y C L +S+ S Y++V P ++ +P+ H+ E
Sbjct: 292 NHNKTLQLLKVGEEDDGEYRC---LAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGE 348
Query: 136 KVVDIPCQAKGVPPPSITW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFA 194
+ CQ +G P P +TW V E+ K ++R + G L +S + P DT + QC A
Sbjct: 349 -TARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR-GALILSNVQPSDTMVTQCEA 406
Query: 195 RNAAGEVQTSTYLAVTSIAPNI-TRGPLDSTVIDGMSVVLACETSGAPRPAITW--QKGE 251
RN G + + Y+ V + I T + G + L C+ GAP P++ W + G
Sbjct: 407 RNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 466
Query: 252 RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRIT 311
+L Q RF P +G+L I +D G Y CLA N + A+L V T+IT
Sbjct: 467 TVL-----QDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQIT 521
Query: 312 KPPQDQSVIKGTQASMVCGVTHDP 335
+ P+ KG++ + C + DP
Sbjct: 522 QGPRSTIEKKGSRVTFTCQASFDP 545
Score = 83.2 bits (204), Expect = 4e-16
Identities = 76/281 (27%), Positives = 117/281 (41%), Gaps = 19/281 (6%)
Query: 32 PSEYPHGTSRGPLWKIRPQGPTRPLIKLHIIWKKDGVLLSGGISDHNRR-----LTIPNP 86
P + +G + QG +P + W+ +G+ + D R L + N
Sbjct: 339 PQSHLYGPGETARLDCQVQGRPQP----EVTWRINGIPVEELAKDQKYRIQRGALILSNV 394
Query: 87 TGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE-PPQFVKEPERHITAEMEKVVDIPCQAK 145
SD +CEA R + + AY+ V++ P + + + A + C+A
Sbjct: 395 QPSDTMVTQCEARNRHGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAF 451
Query: 146 GVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTST 205
G P PS+ W + ++ RF +G L I L +DTG + C A N V
Sbjct: 452 GAPVPSVQWLDEDGTTVLQD-ERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMA 510
Query: 206 YLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP--RPAITWQKGERILASGSVQLPR 263
L V A IT+GP + G V C+ S P +P+ITW+ R L
Sbjct: 511 NLKVKD-ATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKY 569
Query: 264 FTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVV 304
F +E G L+I SD G Y+C+A+ V E+ A L+V
Sbjct: 570 F--IEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV 608
Score = 72.0 bits (175), Expect = 9e-13
Identities = 57/224 (25%), Positives = 104/224 (46%), Gaps = 9/224 (4%)
Query: 122 FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISG 181
F H+ A + + + C A+G P P+I W + + + +++T Q ++ LQ+
Sbjct: 244 FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVT--YQNHNKTLQLLK 301
Query: 182 LVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP 241
+ +D G ++C A N+ G + + Y+ V + AP P G + L C+ G P
Sbjct: 302 VGEEDDGEYRCLAENSLGSARHAYYVTVEA-APYWLHKPQSHLYGPGETARLDCQVQGRP 360
Query: 242 RPAITWQ-KGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 300
+P +TW+ G + Q R ++ G+L++S SD C A N G+ A+A
Sbjct: 361 QPEVTWRINGIPVEELAKDQKYR---IQRGALILSNVQPSDTMVTQCEARNRHGLLLANA 417
Query: 301 DL-VVWARTRI-TKPPQDQSVIKGTQASMVCGVTHDPRVTIRQL 342
+ VV +I T Q ++G+ A ++C P +++ L
Sbjct: 418 YIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL 461
Score = 54.3 bits (129), Expect = 2e-07
Identities = 55/254 (21%), Positives = 98/254 (38%), Gaps = 24/254 (9%)
Query: 116 VLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEK---LTRFRQR 172
V+EPP ++ R + + + C+A G P W +D + ++ +T ++
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSP 90
Query: 173 NDGGLQISG----LVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDST-VID 227
+ G I+G G+++CFA N G + + AP + + V +
Sbjct: 91 HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE 150
Query: 228 GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISD------ 281
G SVVL C + P + +IL Q R T ++G+L + SD
Sbjct: 151 GESVVLPCNPPPSAEPLRIYWMNSKIL--HIKQDERVTMGQNGNLYFANVLTSDNHSDYI 208
Query: 282 -----AGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQS---VIKGTQASMVCGVTH 333
GT T + + + + ++ + R+ P S ++G + C
Sbjct: 209 CHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEG 268
Query: 334 DPRVTIRQLRPGAP 347
P TI+ LRP P
Sbjct: 269 FPTPTIKWLRPSGP 282
Score = 46.6 bits (109), Expect = 4e-05
Identities = 67/311 (21%), Positives = 111/311 (35%), Gaps = 33/311 (10%)
Query: 63 WKKDGVLLSG----GI----SDHNRRLTIPNPTGSDA----GYYECEAVLRSSSVPSVVR 110
W +DGV G+ S H+ TI + A G Y C A + + S
Sbjct: 69 WTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMS--H 126
Query: 111 GAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFR 170
L P++ KE + + E + V +PC P ++ ++ ++ +++ R
Sbjct: 127 EIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT 186
Query: 171 QRNDGGLQISG-LVPDDTGMFQCFA---------RNAAGEVQTSTYLAVTSIAPNI---T 217
+G L + L D+ + C A + +++ ++ P + T
Sbjct: 187 MGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPT 246
Query: 218 RGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFT-PLESGSLLISP 276
+ G +VL C G P P I W + SG + R T + +L +
Sbjct: 247 NSSSHLVALQGQPLVLECIAEGFPTPTIKWLR-----PSGPMPADRVTYQNHNKTLQLLK 301
Query: 277 THISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPR 336
D G Y CLA NS G + + V A PQ G A + C V P+
Sbjct: 302 VGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQ 361
Query: 337 VTIRQLRPGAP 347
+ G P
Sbjct: 362 PEVTWRINGIP 372
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 112 bits (279), Expect = 8e-25
Identities = 88/267 (32%), Positives = 122/267 (45%), Gaps = 24/267 (8%)
Query: 89 SDAGYYECEAVLRSSSVPSVVRGA-YLSVLEPPQF-VKEPERHITAEMEKVVDIPCQAKG 146
+D G Y+C A S+ V R + +L V E PQ + +H + +E V + C A G
Sbjct: 463 TDGGRYQCVA----SNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE--VKVSCSASG 516
Query: 147 VPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTY 206
P P I+W +++ ++ + +R G L I G+ P+D G + C A N G Q +
Sbjct: 517 YPTPHISWSRESQALQED--SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVT 574
Query: 207 LAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKG--ERILA-SGSVQLPR 263
L T P+++ V G VL CE SG P P + W +G E ILA GS
Sbjct: 575 LYYTD-PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS----- 628
Query: 264 FTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGT 323
SG L I DAGTYTC A N G A L V ++T+ P+D +V G
Sbjct: 629 ----SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGR 684
Query: 324 QASMVCGVTHDPRVTIRQLR-PGAPSG 349
A + C T P T+ R G P G
Sbjct: 685 SALLACRATGRPPPTVTWRRGDGQPLG 711
Score = 110 bits (275), Expect = 2e-24
Identities = 96/327 (29%), Positives = 140/327 (42%), Gaps = 23/327 (7%)
Query: 61 IIWKKDGV-LLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEP 119
+IW + G+ ++ + +L IP DAG Y C AV + ++ L+V
Sbjct: 612 VIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQ---LAVGHA 668
Query: 120 PQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKL-----TRFRQRND 174
PQ + P R +T E+ + + C+A G PPP++TW + +L +R RQ +
Sbjct: 669 PQLTELP-RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS 727
Query: 175 GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIA-PNITRGPLDSTVIDGMSVVL 233
G L + P+D + C ARN G+VQ L VT A P I V++G V L
Sbjct: 728 GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSL 787
Query: 234 AC-ETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 292
C +G P P W K R L GS R + GSL + AG Y+C+ATN+
Sbjct: 788 PCIVLAGRPLPERHWLKDGRPLPPGS----RHSIRADGSLHLDRALQEHAGRYSCVATNT 843
Query: 293 RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTI---RQLRPGAPSG 349
G +LVV RI +G AS+ C + P TI ++ G
Sbjct: 844 AGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRG 903
Query: 350 GHWTYDS----LYSHPQMRLRGAQVGT 372
H+ L + P + GA V T
Sbjct: 904 PHYNVSKEGTLLIAQPSAQDAGAYVCT 930
Score = 105 bits (263), Expect = 6e-23
Identities = 78/266 (29%), Positives = 118/266 (44%), Gaps = 15/266 (5%)
Query: 89 SDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVP 148
++ G YEC AV R+ + + + PPQ V P ++T + + C+ G
Sbjct: 372 AEEGTYECTAVSRAGT--GRAKAQIVVTDPPPQLVPAP--NVTVSPGETAVLSCRVLGEA 427
Query: 149 PPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLA 208
P ++TW +D V+ R Q D L+ISG++P D G +QC A NA G + S +L
Sbjct: 428 PYNLTWVRDWRVLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLL 486
Query: 209 VTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLE 268
V AP ++ G+ V ++C SG P P I+W + + L S R
Sbjct: 487 VRE-APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS----RIHVDA 541
Query: 269 SGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMV 328
G+L+I DAG Y+C ATN G D+ + L ++ V G +A +V
Sbjct: 542 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 601
Query: 329 CGVTHDPRVTIRQLRPG-----APSG 349
C + P + R G AP G
Sbjct: 602 CEASGVPPPRVIWYRGGLEMILAPEG 627
Score = 99.0 bits (245), Expect = 7e-21
Identities = 89/276 (32%), Positives = 121/276 (43%), Gaps = 23/276 (8%)
Query: 54 RPLIKLHIIWKKDGVLLSGGISDHNRR----LTIPNPTGSDAGYYECEAVLRSSSVPSVV 109
RPL + H W KDG L G S H+ R L + AG Y C A +++ S
Sbjct: 795 RPLPERH--WLKDGRPLPPG-SRHSIRADGSLHLDRALQEHAGRYSCVA---TNTAGSQH 848
Query: 110 RGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRF 169
R L V PP+ HIT E +PC A GVP P+ITW K+ + + +
Sbjct: 849 RDVELVVQVPPRIHPTATHHITNEGVPA-SLPCVASGVPAPTITWTKETNAL-TSRGPHY 906
Query: 170 RQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTS---IAPNITRG---PLDS 223
+G L I+ D G + C A N G L+V + I N +R PL
Sbjct: 907 NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQV 966
Query: 224 TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAG 283
T G V L CE G+P P +TW K R + + R+ L SGSL ++ + D+G
Sbjct: 967 TAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT---NRYGLLPSGSLRLAQVQVGDSG 1023
Query: 284 TYTCLATNSRGVDEASADLVVWARTRITKPPQDQSV 319
Y C A+N G AS V+ + R + PQ V
Sbjct: 1024 HYECTASNPAG--SASHRYVLGVQGRTSWQPQSLPV 1057
Score = 84.0 bits (206), Expect = 2e-16
Identities = 92/370 (24%), Positives = 127/370 (34%), Gaps = 30/370 (8%)
Query: 23 GHRTPFPWGPSEYPHGTSRGPLWKIRPQGPTRPLIKLHIIWKKD-----GVLLSGGISDH 77
GH P + R L R G P + W++ G+ L G
Sbjct: 666 GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVT----WRRGDGQPLGLRLGAGRGSR 721
Query: 78 NRR-----LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITA 132
+R+ L + D Y CEA V + R ++ PPQ
Sbjct: 722 SRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEAR-LIVTGHAPPQIASSAPTVRVL 780
Query: 133 EMEKVVDIPCQA-KGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQ 191
E + V +PC G P P W KD + +R R DG L + + + G +
Sbjct: 781 EGQPV-SLPCIVLAGRPLPERHWLKDGRPLPPG--SRHSIRADGSLHLDRALQEHAGRYS 837
Query: 192 CFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGE 251
C A N AG L V + P I +G+ L C SG P P ITW K
Sbjct: 838 CVATNTAGSQHRDVELVV-QVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKET 896
Query: 252 RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRI- 310
L S P + + G+LLI+ DAG Y C ATN+ G L V + RI
Sbjct: 897 NALTSRG---PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIH 953
Query: 311 ------TKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGGHWTYDSLYSHPQMR 364
P + G + ++ C P + + P L +R
Sbjct: 954 MNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLR 1013
Query: 365 LRGAQVGTRG 374
L QVG G
Sbjct: 1014 LAQVQVGDSG 1023
Score = 64.7 bits (156), Expect = 1e-10
Identities = 57/195 (29%), Positives = 85/195 (43%), Gaps = 17/195 (8%)
Query: 61 IIWKKDGVLLSGGISDHN----RRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 116
I W K+ L+ +N L I P+ DAG Y C A +++V + LSV
Sbjct: 890 ITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTA---TNTVGFSSQEMRLSV 946
Query: 117 LEPPQFVKEPERH------ITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFR 170
P+ R+ +TA+ + V + C+AKG PPP +TW KD+ V R+
Sbjct: 947 NTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVP-PITNRYG 1005
Query: 171 QRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAV---TSIAPNITRGPLDSTVID 227
G L+++ + D+G ++C A N AG L V TS P P +
Sbjct: 1006 LLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLS 1065
Query: 228 GMSVVLACETSGAPR 242
G+SV L T + R
Sbjct: 1066 GLSVPLLQPTPRSVR 1080
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 112 bits (279), Expect = 8e-25
Identities = 89/307 (28%), Positives = 134/307 (43%), Gaps = 30/307 (9%)
Query: 45 WKIRPQGPTRPLIKLHIIWKKDGVLLSGGISD--HNRRLTIPNPTGSDAGYYECEAVLRS 102
+K +G P ++ W+KD L + + L I T D G Y C A
Sbjct: 281 FKCEARGDPVPTVR----WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA---E 333
Query: 103 SSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA--- 159
+ V A L+V EPP FV +P + A + + V C+A G P P+I W ++ +
Sbjct: 334 NMVGKAEASATLTVQEPPHFVVKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNL 392
Query: 160 ---VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIA--- 213
+ +RF G L I+ + D G + C N AG + T YL VT +
Sbjct: 393 LFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADR 452
Query: 214 --PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGS 271
P I +GP++ TV + VL+C +G+P P I W+K ++ S Q R LE+G
Sbjct: 453 PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLV---STQDSRIKQLENGV 509
Query: 272 LLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGV 331
L I + D G YTC+A+ G SA + V +PP + T +++
Sbjct: 510 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP------RPTDPNLIPSA 563
Query: 332 THDPRVT 338
P VT
Sbjct: 564 PSKPEVT 570
Score = 93.6 bits (231), Expect = 3e-19
Identities = 73/233 (31%), Positives = 104/233 (44%), Gaps = 16/233 (6%)
Query: 119 PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR---NDG 175
PP+ V+ P I ++ E + C+A+G P P+I WYK VE +K R G
Sbjct: 67 PPRIVEHPSDLIVSKGEPAT-LNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125
Query: 176 GLQISGLV-----PDDTGMFQCFARNAAGE-VQTSTYLAVTSIAPNITRGPLDSTVIDGM 229
L +V D G++ C ARN GE V + L V + + + P D V G
Sbjct: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185
Query: 230 SVVLACE-TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 288
V+ C+ G P P I+W+K L ++ + G L+I+ T SDAG Y C+
Sbjct: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERI----TIRGGKLMITYTRKSDAGKYVCV 241
Query: 289 ATNSRGVDEAS-ADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIR 340
TN G E+ A+L V R K P + +V A C DP T+R
Sbjct: 242 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVR 294
Score = 89.4 bits (220), Expect = 5e-18
Identities = 76/259 (29%), Positives = 110/259 (42%), Gaps = 12/259 (4%)
Query: 90 DAGYYECEAVLRSSSVPSVVRGAYLSV-LEPPQFVKEPERHITAEMEKVVDIPCQA-KGV 147
D G Y C V R+ +V A L V + F + P + A E V + CQ +G
Sbjct: 141 DEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAV-MECQPPRGH 197
Query: 148 PPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYL 207
P P+I+W KD + ++ +K R R G L I+ D G + C N GE ++
Sbjct: 198 PEPTISWKKDGSPLD-DKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVAE 255
Query: 208 AVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPL 267
P+ + P + V S CE G P P + W+K + G + R+
Sbjct: 256 LTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD-----GELPKSRYEIR 310
Query: 268 ESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASM 327
+ +L I D G+YTC+A N G EASA L V P+DQ V G +
Sbjct: 311 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTF 370
Query: 328 VCGVTHDPRVTIRQLRPGA 346
C T +P+ I R G+
Sbjct: 371 QCEATGNPQPAIFWRREGS 389
Score = 48.9 bits (115), Expect = 8e-06
Identities = 46/154 (29%), Positives = 55/154 (35%), Gaps = 9/154 (5%)
Query: 203 TSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQL 261
T + L P I P D V G L C+ G P P I W K GER+
Sbjct: 57 TGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 116
Query: 262 PRFTPLESGSLLI-----SPTHISDAGTYTCLATNSRG--VDEASADLVVWARTRITKPP 314
L SGSL D G Y C+A N G V ++ V R + P
Sbjct: 117 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 176
Query: 315 QDQSVIKGTQASMVCGVTH-DPRVTIRQLRPGAP 347
D V G A M C P TI + G+P
Sbjct: 177 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP 210
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 111 bits (277), Expect = 1e-24
Identities = 74/231 (32%), Positives = 111/231 (48%), Gaps = 9/231 (3%)
Query: 118 EPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGL 177
+ P+ EP+ + V C+A+G P P I W + +++E TR +DG L
Sbjct: 232 QSPRITFEPQ-DVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTL 290
Query: 178 QISGLVPDDTGMFQCFARNAAGEVQT-STYLAVTSI--APNITRGPLDSTVIDGMSVVLA 234
I D G++QC ARN+AGE +T S L +S+ P+ P D+ V+ G S L
Sbjct: 291 MIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLE 350
Query: 235 CETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRG 294
C +G P P ITW + + GS R SG L + T D G +TC A NS G
Sbjct: 351 CMATGHPHPLITWTRDNGLELDGS----RHVATSSGLYLQNITQ-RDHGRFTCHANNSHG 405
Query: 295 VDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPG 345
+A+A+++V A + T P+DQ V++ +C +P I + G
Sbjct: 406 TVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTG 456
Score = 102 bits (253), Expect = 8e-22
Identities = 86/272 (31%), Positives = 120/272 (44%), Gaps = 20/272 (7%)
Query: 81 LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGA---YLSVLEPPQFVKEPERHITAEMEKV 137
L I N SD G Y+C A R+S+ + + A Y S+ P FV +P+ +
Sbjct: 290 LMIRNTRESDQGVYQCMA--RNSAGEAKTQSAMLRYSSLPAKPSFVIQPQ-DTEVLIGTS 346
Query: 138 VDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQ-RNDGGLQISGLVPDDTGMFQCFARN 196
+ C A G P P ITW +D + +L R GL + + D G F C A N
Sbjct: 347 TTLECMATGHPHPLITWTRDNGL----ELDGSRHVATSSGLYLQNITQRDHGRFTCHANN 402
Query: 197 AAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK-GERILA 255
+ G VQ + + V + P T P D V++ +V CE G P P I W K G ++
Sbjct: 403 SHGTVQAAANIIVQA-PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV 461
Query: 256 SGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVV--WARTRITKP 313
G + T L SG+L I D G Y C A +S GV + S L V A T+
Sbjct: 462 EG-----QHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQL 516
Query: 314 PQDQSVIKGTQASMVCGVTHDPRVTIRQLRPG 345
PQD SV G ++ C +P+ I + G
Sbjct: 517 PQDTSVEVGKNINISCHAQGEPQPIITWNKEG 548
Score = 99.4 bits (246), Expect = 5e-21
Identities = 81/251 (32%), Positives = 118/251 (47%), Gaps = 17/251 (6%)
Query: 61 IIWKKDGVLLSGGISDH---NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL 117
I W +D L G S H + L + N T D G + C A ++S +V A + V
Sbjct: 361 ITWTRDNGLELDG-SRHVATSSGLYLQNITQRDHGRFTCHA---NNSHGTVQAAANIIVQ 416
Query: 118 EPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGL 177
PPQF P+ + E E V+ C+A G PPP I W K + VE + + G L
Sbjct: 417 APPQFTVTPKDQVVLE-EHAVEWLCEADGNPPPVIVWTKTGGQLPVEG--QHTVLSSGTL 473
Query: 178 QISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI-TRGPLDSTVIDGMSVVLACE 236
+I D G ++C A ++ G + S L V A + T+ P D++V G ++ ++C
Sbjct: 474 RIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCH 533
Query: 237 TSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGV 295
G P+P ITW K G +I SG +F + G+L I D G Y C+A NS G+
Sbjct: 534 AQGEPQPIITWNKEGVQITESG-----KFHVDDEGTLTIYDAGFPDQGRYECVARNSFGL 588
Query: 296 DEASADLVVWA 306
+ L V A
Sbjct: 589 AVTNMFLTVTA 599
Score = 67.0 bits (162), Expect = 3e-11
Identities = 55/181 (30%), Positives = 83/181 (45%), Gaps = 31/181 (17%)
Query: 45 WKIRPQGPTRPLIKLHIIWKKDG---------VLLSGGISDHNRRLTIPNPTGSDAGYYE 95
W G P+I +W K G +LS G L I D G YE
Sbjct: 438 WLCEADGNPPPVI----VWTKTGGQLPVEGQHTVLSSGT------LRIDRAAQHDQGQYE 487
Query: 96 CEAV----LRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPS 151
C+AV ++ SV V+ L+V F + P+ + E+ K ++I C A+G P P
Sbjct: 488 CQAVSSLGVKKVSVQLTVKPKALAV-----FTQLPQ-DTSVEVGKNINISCHAQGEPQPI 541
Query: 152 ITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTS 211
ITW K+ V++ + +F ++G L I D G ++C ARN+ G T+ +L VT+
Sbjct: 542 ITWNKEG--VQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTA 599
Query: 212 I 212
I
Sbjct: 600 I 600
>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
Length = 1018
Score = 110 bits (275), Expect = 2e-24
Identities = 85/291 (29%), Positives = 132/291 (45%), Gaps = 39/291 (13%)
Query: 61 IIWKK--DGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRG-----AY 113
I W+K + + + IS L I N D G YECEA +RG A
Sbjct: 273 IRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEA--------ENIRGKDKHQAR 324
Query: 114 LSVLEPPQFVKEPERHIT-AEMEKVVDI--PCQAKGVPPPSITWYKDAAVVEVEKLTRFR 170
+ V P++V+ HI E++ D+ PC A G P P+I W K+
Sbjct: 325 IYVQAFPEWVE----HINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAY--------- 371
Query: 171 QRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVI--DG 228
+ G L++ + ++ GM+QC A N G + + L + ++AP P+ ++ G
Sbjct: 372 --HKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKG 429
Query: 229 MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 288
V++ C+ AP+P +W KG L + S R E GSL I+ +D G YTC
Sbjct: 430 GRVIIECKPKAAPKPKFSWSKGTEWLVNSS----RILIWEDGSLEINNITRNDGGIYTCF 485
Query: 289 ATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTI 339
A N+RG ++ LV+ TRI P + + G A+M C + DP + +
Sbjct: 486 AENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDL 536
Score = 80.5 bits (197), Expect = 2e-15
Identities = 68/242 (28%), Positives = 107/242 (44%), Gaps = 13/242 (5%)
Query: 70 LSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE-PPQFVKEP-E 127
L G + H L + + T +AG Y+C A ++ ++ A L +L P F P +
Sbjct: 365 LKNGYAYHKGELRLYDVTFENAGMYQCIA---ENTYGAIYANAELKILALAPTFEMNPMK 421
Query: 128 RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDT 187
+ I A V I C+ K P P +W K + +R DG L+I+ + +D
Sbjct: 422 KKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLV--NSSRILIWEDGSLEINNITRNDG 479
Query: 188 GMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAIT- 246
G++ CFA N G+ ++ L +T I P+++ + G + + C S P +T
Sbjct: 480 GIYTCFAENNRGKANSTGTLVITD-PTRIILAPINADITVGENATMQCAASFDPALDLTF 538
Query: 247 -WQKGERILASG--SVQLPRFTPLES-GSLLISPTHISDAGTYTCLATNSRGVDEASADL 302
W ++ ++ R L+S G LLI + AG YTC A ASADL
Sbjct: 539 VWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADL 598
Query: 303 VV 304
VV
Sbjct: 599 VV 600
Score = 70.5 bits (171), Expect = 3e-12
Identities = 63/241 (26%), Positives = 99/241 (41%), Gaps = 27/241 (11%)
Query: 74 ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPE------ 127
+S N L I N SD G Y C + S S+ V ++ ++ P+ +P
Sbjct: 189 VSQTNGNLYIANVEASDKGNYSC--FVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVV 246
Query: 128 --RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPD 185
+ + A M + V + C A G P P I W K V+E T + L+I + +
Sbjct: 247 QFKDVYALMGQNVTLECFALGNPVPDIRWRK---VLEPMPSTAEISTSGAVLKIFNIQLE 303
Query: 186 DTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAI 245
D G+++C A N G+ + + V + P D+ V G + C +G P P I
Sbjct: 304 DEGIYECEAENIRGKDKHQARIYVQAF-PEWVEHINDTEVDIGSDLYWPCVATGKPIPTI 362
Query: 246 TWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW 305
W K G ++L T +AG Y C+A N+ G A+A+L +
Sbjct: 363 RWLKNGYAYHKGELRLYDVT-------------FENAGMYQCIAENTYGAIYANAELKIL 409
Query: 306 A 306
A
Sbjct: 410 A 410
Score = 61.2 bits (147), Expect = 2e-09
Identities = 87/335 (25%), Positives = 130/335 (38%), Gaps = 28/335 (8%)
Query: 81 LTIPNPTGS-DAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVD 139
L I NP DAG Y C A V S L+P F E + + K +
Sbjct: 98 LVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDP--FPPEERPEVRVKEGKGMV 155
Query: 140 IPCQAKGVPPPSITW---YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARN 196
+ C P +++ + V RF + +G L I+ + D G + CF +
Sbjct: 156 LLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 215
Query: 197 AAGEVQT-STYLAVTSIAPNITRG-PLDSTV-------IDGMSVVLACETSGAPRPAITW 247
+ S ++ + I T+ P D V + G +V L C G P P I W
Sbjct: 216 PSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRW 275
Query: 248 QKG-ERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSRGVDEASADLVVW 305
+K E + ++ + SG++L I + D G Y C A N RG D+ A + V
Sbjct: 276 RKVLEPMPSTAEIST-------SGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQ 328
Query: 306 ARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAP--SGGHWTYDSLYSHPQM 363
A + D V G+ C T P TIR L+ G G YD + + M
Sbjct: 329 AFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGELRLYDVTFENAGM 388
Query: 364 RLRGAQVGTRGSRLLANTDSQRTYQRPQFEKHLMK 398
A+ T G+ + AN + + P FE + MK
Sbjct: 389 YQCIAE-NTYGA-IYANAELKILALAPTFEMNPMK 421
Score = 33.9 bits (76), Expect = 0.27
Identities = 20/67 (29%), Positives = 33/67 (49%), Gaps = 7/67 (10%)
Query: 231 VVLACETSGAPRPAITWQKGERILASGSVQLP--RFTPLESGSLLISPTHISDAGTYTCL 288
V L C +P P W+ + +G V L R++ + ++ +P DAG Y CL
Sbjct: 61 VSLNCRARASPFPVYKWR-----MNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCL 115
Query: 289 ATNSRGV 295
A+N+ G+
Sbjct: 116 ASNNYGM 122
>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
Length = 1007
Score = 110 bits (275), Expect = 2e-24
Identities = 85/291 (29%), Positives = 132/291 (45%), Gaps = 39/291 (13%)
Query: 61 IIWKK--DGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRG-----AY 113
I W+K + + + IS L I N D G YECEA +RG A
Sbjct: 262 IRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEA--------ENIRGKDKHQAR 313
Query: 114 LSVLEPPQFVKEPERHIT-AEMEKVVDI--PCQAKGVPPPSITWYKDAAVVEVEKLTRFR 170
+ V P++V+ HI E++ D+ PC A G P P+I W K+
Sbjct: 314 IYVQAFPEWVE----HINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAY--------- 360
Query: 171 QRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVI--DG 228
+ G L++ + ++ GM+QC A N G + + L + ++AP P+ ++ G
Sbjct: 361 --HKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKG 418
Query: 229 MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 288
V++ C+ AP+P +W KG L + S R E GSL I+ +D G YTC
Sbjct: 419 GRVIIECKPKAAPKPKFSWSKGTEWLVNSS----RILIWEDGSLEINNITRNDGGIYTCF 474
Query: 289 ATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTI 339
A N+RG ++ LV+ TRI P + + G A+M C + DP + +
Sbjct: 475 AENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDL 525
Score = 80.5 bits (197), Expect = 2e-15
Identities = 68/242 (28%), Positives = 107/242 (44%), Gaps = 13/242 (5%)
Query: 70 LSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE-PPQFVKEP-E 127
L G + H L + + T +AG Y+C A ++ ++ A L +L P F P +
Sbjct: 354 LKNGYAYHKGELRLYDVTFENAGMYQCIA---ENTYGAIYANAELKILALAPTFEMNPMK 410
Query: 128 RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDT 187
+ I A V I C+ K P P +W K + +R DG L+I+ + +D
Sbjct: 411 KKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLV--NSSRILIWEDGSLEINNITRNDG 468
Query: 188 GMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAIT- 246
G++ CFA N G+ ++ L +T I P+++ + G + + C S P +T
Sbjct: 469 GIYTCFAENNRGKANSTGTLVITD-PTRIILAPINADITVGENATMQCAASFDPALDLTF 527
Query: 247 -WQKGERILASG--SVQLPRFTPLES-GSLLISPTHISDAGTYTCLATNSRGVDEASADL 302
W ++ ++ R L+S G LLI + AG YTC A ASADL
Sbjct: 528 VWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADL 587
Query: 303 VV 304
VV
Sbjct: 588 VV 589
Score = 70.5 bits (171), Expect = 3e-12
Identities = 63/241 (26%), Positives = 99/241 (41%), Gaps = 27/241 (11%)
Query: 74 ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPE------ 127
+S N L I N SD G Y C + S S+ V ++ ++ P+ +P
Sbjct: 178 VSQTNGNLYIANVEASDKGNYSC--FVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVV 235
Query: 128 --RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPD 185
+ + A M + V + C A G P P I W K V+E T + L+I + +
Sbjct: 236 QFKDVYALMGQNVTLECFALGNPVPDIRWRK---VLEPMPSTAEISTSGAVLKIFNIQLE 292
Query: 186 DTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAI 245
D G+++C A N G+ + + V + P D+ V G + C +G P P I
Sbjct: 293 DEGIYECEAENIRGKDKHQARIYVQAF-PEWVEHINDTEVDIGSDLYWPCVATGKPIPTI 351
Query: 246 TWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW 305
W K G ++L T +AG Y C+A N+ G A+A+L +
Sbjct: 352 RWLKNGYAYHKGELRLYDVT-------------FENAGMYQCIAENTYGAIYANAELKIL 398
Query: 306 A 306
A
Sbjct: 399 A 399
Score = 61.2 bits (147), Expect = 2e-09
Identities = 87/335 (25%), Positives = 130/335 (38%), Gaps = 28/335 (8%)
Query: 81 LTIPNPTGS-DAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVD 139
L I NP DAG Y C A V S L+P F E + + K +
Sbjct: 87 LVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDP--FPPEERPEVRVKEGKGMV 144
Query: 140 IPCQAKGVPPPSITW---YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARN 196
+ C P +++ + V RF + +G L I+ + D G + CF +
Sbjct: 145 LLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 204
Query: 197 AAGEVQT-STYLAVTSIAPNITRG-PLDSTV-------IDGMSVVLACETSGAPRPAITW 247
+ S ++ + I T+ P D V + G +V L C G P P I W
Sbjct: 205 PSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRW 264
Query: 248 QKG-ERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSRGVDEASADLVVW 305
+K E + ++ + SG++L I + D G Y C A N RG D+ A + V
Sbjct: 265 RKVLEPMPSTAEIST-------SGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQ 317
Query: 306 ARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAP--SGGHWTYDSLYSHPQM 363
A + D V G+ C T P TIR L+ G G YD + + M
Sbjct: 318 AFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGELRLYDVTFENAGM 377
Query: 364 RLRGAQVGTRGSRLLANTDSQRTYQRPQFEKHLMK 398
A+ T G+ + AN + + P FE + MK
Sbjct: 378 YQCIAE-NTYGA-IYANAELKILALAPTFEMNPMK 410
Score = 33.9 bits (76), Expect = 0.27
Identities = 20/67 (29%), Positives = 33/67 (49%), Gaps = 7/67 (10%)
Query: 231 VVLACETSGAPRPAITWQKGERILASGSVQLP--RFTPLESGSLLISPTHISDAGTYTCL 288
V L C +P P W+ + +G V L R++ + ++ +P DAG Y CL
Sbjct: 50 VSLNCRARASPFPVYKWR-----MNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCL 104
Query: 289 ATNSRGV 295
A+N+ G+
Sbjct: 105 ASNNYGM 111
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 110 bits (274), Expect = 3e-24
Identities = 71/225 (31%), Positives = 108/225 (48%), Gaps = 7/225 (3%)
Query: 123 VKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGL-QISG 181
+ P + A +E+V C + P P I+W ++ ++++ TR+ R +G L I
Sbjct: 30 ITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFD-TRYSIRENGQLLTILS 88
Query: 182 LVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP 241
+ D G++ C A N G S + P ITR P++ +I+G+ VL C T G P
Sbjct: 89 VEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNP 148
Query: 242 RPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEAS-A 300
+P+++W KG+ L S R LESGSL I DAG Y C+A NS G +
Sbjct: 149 KPSVSWIKGDSPLRENS----RIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVV 204
Query: 301 DLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPG 345
L V RI + P+ +V G+ ++ C T P TI + G
Sbjct: 205 KLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENG 249
Score = 90.9 bits (224), Expect = 2e-18
Identities = 68/240 (28%), Positives = 105/240 (43%), Gaps = 15/240 (6%)
Query: 61 IIWKKDGVLLS-----GGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGA-YL 114
I W ++ +L+ I ++ + LTI + SD G Y C A ++ V V L
Sbjct: 59 ISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTA---NNGVGGAVESCGAL 115
Query: 115 SVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 174
V P+ + P E K V +PC G P PS++W K + + + +R
Sbjct: 116 QVKMKPKITRPPINVKIIEGLKAV-LPCTTMGNPKPSVSWIKGDS--PLRENSRIAVLES 172
Query: 175 GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLA 234
G L+I + +D G ++C A+N+ G + + I R P V G V L
Sbjct: 173 GSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLH 232
Query: 235 CETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRG 294
C +G P P ITW + ++SGS+Q + L + I+ G YTC+ATN G
Sbjct: 233 CTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQL---FITKPGLYTCIATNKHG 289
Score = 52.0 bits (123), Expect = 9e-07
Identities = 40/140 (28%), Positives = 70/140 (50%), Gaps = 11/140 (7%)
Query: 213 APNITRGPLDSTVIDGMSVVLA---CETSGAPRPAITWQKGERILASGSVQLPRFTPLES 269
AP IT PL++ +D + +A C P+P I+W + + ++ R++ E+
Sbjct: 27 APVITT-PLET--VDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDT---RYSIREN 80
Query: 270 GSLL-ISPTHISDAGTYTCLATNS-RGVDEASADLVVWARTRITKPPQDQSVIKGTQASM 327
G LL I SD G Y C A N G E+ L V + +IT+PP + +I+G +A +
Sbjct: 81 GQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVL 140
Query: 328 VCGVTHDPRVTIRQLRPGAP 347
C +P+ ++ ++ +P
Sbjct: 141 PCTTMGNPKPSVSWIKGDSP 160
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 108 bits (271), Expect = 7e-24
Identities = 90/281 (32%), Positives = 118/281 (41%), Gaps = 20/281 (7%)
Query: 81 LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDI 140
L IPN DAG YEC A +S + RG L V P +V E + +
Sbjct: 354 LEIPNVQLDDAGIYECRA--ENSRGKNSFRGQ-LQVYTYPHWV-EKLNDTQLDSGSPLRW 409
Query: 141 PCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGE 200
C+A G P P+ W K+ V + +R N G L I + D GM+QC A N G
Sbjct: 410 ECKATGKPRPTYRWLKNG--VPLSPQSRVEMVN-GVLMIHNVNQSDAGMYQCLAENKYGA 466
Query: 201 VQTSTYLAVTSIAPNITRGPLDSTVI--DGMSVVLACETSGAPRPAITWQKGERILASGS 258
+ S L + + AP L T+I VV+ C+ G+P+P I+W+KG+R +
Sbjct: 467 IYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENK 526
Query: 259 VQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQS 318
R L GSL I SD G Y C N G E A L V TRI P+
Sbjct: 527 ----RIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTE 582
Query: 319 VIKGTQASMVCGVTHDPR--VTIRQLRPGAP-----SGGHW 352
+ G + C HD VT G P GGH+
Sbjct: 583 LTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHF 623
Score = 71.6 bits (174), Expect = 1e-12
Identities = 69/278 (24%), Positives = 101/278 (36%), Gaps = 20/278 (7%)
Query: 83 IPNPT-GSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIP 141
I NP+ D+G+Y+C A S+ S R A L F ++ + V +
Sbjct: 159 ISNPSEAKDSGHYQCLATNTVGSILS--REATLQFAYLGNFSGRTRSAVSVREGQGVVLM 216
Query: 142 CQAKGVPPPSI-TW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAG 199
C P I +W + + E RF + G L IS + D G + C +N
Sbjct: 217 CSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVT 276
Query: 200 EVQTSTYLAVTSIAPNITRG----------PLDSTVIDGMSVVLACETSGAPRPAITWQK 249
+ + ++ + G P T G +V + C G P P ITW K
Sbjct: 277 NARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMK 336
Query: 250 GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTR 309
+G + L I + DAG Y C A NSRG + L V+
Sbjct: 337 -----VNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPH 391
Query: 310 ITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAP 347
+ D + G+ C T PR T R L+ G P
Sbjct: 392 WVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVP 429
Score = 67.4 bits (163), Expect = 2e-11
Identities = 75/276 (27%), Positives = 112/276 (40%), Gaps = 22/276 (7%)
Query: 40 SRGPL-WKIRPQGPTRPLIKLHIIWKKDGVLLS--GGISDHNRRLTIPNPTGSDAGYYEC 96
S PL W+ + G RP + W K+GV LS + N L I N SDAG Y+C
Sbjct: 403 SGSPLRWECKATGKPRPTYR----WLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQC 458
Query: 97 EAVLRSSSVPSVVRGAYLSVL--EPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITW 154
L + ++ A L +L P + + ++ I ++ V I C+ +G P P+I+W
Sbjct: 459 ---LAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISW 515
Query: 155 YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAP 214
K V K R DG L+I D G + C N G + L+V
Sbjct: 516 KKGDRAVRENK--RIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE-PT 572
Query: 215 NITRGPLDSTVIDGMSVVLACETSGAPRPAITWQ---KGERI---LASGSVQLPRFTPLE 268
I P + + G S+VL C+ +T+ KG+ I G + R
Sbjct: 573 RIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIR-AQAS 631
Query: 269 SGSLLISPTHISDAGTYTCLATNSRGVDEASADLVV 304
S L+I + AG Y C + A+L+V
Sbjct: 632 SADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLV 667
Score = 66.6 bits (161), Expect = 4e-11
Identities = 57/182 (31%), Positives = 83/182 (45%), Gaps = 15/182 (8%)
Query: 120 PQFVKEPERHI--TAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGL 177
P FV+EP+ I T EK V + C+ +G P PS W ++ +++E R+ DG
Sbjct: 99 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRY-SLIDGTF 157
Query: 178 QISG-LVPDDTGMFQCFARNAAGEV---QTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL 233
IS D+G +QC A N G + + + A TR + +V +G VVL
Sbjct: 158 IISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAV--SVREGQGVVL 215
Query: 234 ACE-TSGAPRPAITWQKGE--RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLAT 290
C +P +W E +A S RF E+G+L IS SD G+Y CL
Sbjct: 216 MCSPPPHSPEIIYSWVFNEFPSFVAEDS---RRFISQETGNLYISKVQTSDVGSYICLVK 272
Query: 291 NS 292
N+
Sbjct: 273 NT 274
Score = 40.0 bits (92), Expect = 0.004
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 7/76 (9%)
Query: 220 PLDSTVIDGMSVVLACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTH 278
P DS D V L CE G P P+ W + G I R++ ++ ++ +P+
Sbjct: 111 PTDS---DEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDY---RYSLIDGTFIISNPSE 164
Query: 279 ISDAGTYTCLATNSRG 294
D+G Y CLATN+ G
Sbjct: 165 AKDSGHYQCLATNTVG 180
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 108 bits (271), Expect = 7e-24
Identities = 90/281 (32%), Positives = 118/281 (41%), Gaps = 20/281 (7%)
Query: 81 LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDI 140
L IPN DAG YEC A +S + RG L V P +V E + +
Sbjct: 280 LEIPNVQLDDAGIYECRA--ENSRGKNSFRGQ-LQVYTYPHWV-EKLNDTQLDSGSPLRW 335
Query: 141 PCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGE 200
C+A G P P+ W K+ V + +R N G L I + D GM+QC A N G
Sbjct: 336 ECKATGKPRPTYRWLKNG--VPLSPQSRVEMVN-GVLMIHNVNQSDAGMYQCLAENKYGA 392
Query: 201 VQTSTYLAVTSIAPNITRGPLDSTVI--DGMSVVLACETSGAPRPAITWQKGERILASGS 258
+ S L + + AP L T+I VV+ C+ G+P+P I+W+KG+R +
Sbjct: 393 IYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENK 452
Query: 259 VQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQS 318
R L GSL I SD G Y C N G E A L V TRI P+
Sbjct: 453 ----RIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTE 508
Query: 319 VIKGTQASMVCGVTHDPR--VTIRQLRPGAP-----SGGHW 352
+ G + C HD VT G P GGH+
Sbjct: 509 LTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHF 549
Score = 71.6 bits (174), Expect = 1e-12
Identities = 69/278 (24%), Positives = 101/278 (36%), Gaps = 20/278 (7%)
Query: 83 IPNPT-GSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIP 141
I NP+ D+G+Y+C A S+ S R A L F ++ + V +
Sbjct: 85 ISNPSEAKDSGHYQCLATNTVGSILS--REATLQFAYLGNFSGRTRSAVSVREGQGVVLM 142
Query: 142 CQAKGVPPPSI-TW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAG 199
C P I +W + + E RF + G L IS + D G + C +N
Sbjct: 143 CSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVT 202
Query: 200 EVQTSTYLAVTSIAPNITRG----------PLDSTVIDGMSVVLACETSGAPRPAITWQK 249
+ + ++ + G P T G +V + C G P P ITW K
Sbjct: 203 NARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMK 262
Query: 250 GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTR 309
+G + L I + DAG Y C A NSRG + L V+
Sbjct: 263 -----VNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPH 317
Query: 310 ITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAP 347
+ D + G+ C T PR T R L+ G P
Sbjct: 318 WVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVP 355
Score = 67.4 bits (163), Expect = 2e-11
Identities = 75/276 (27%), Positives = 112/276 (40%), Gaps = 22/276 (7%)
Query: 40 SRGPL-WKIRPQGPTRPLIKLHIIWKKDGVLLS--GGISDHNRRLTIPNPTGSDAGYYEC 96
S PL W+ + G RP + W K+GV LS + N L I N SDAG Y+C
Sbjct: 329 SGSPLRWECKATGKPRPTYR----WLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQC 384
Query: 97 EAVLRSSSVPSVVRGAYLSVL--EPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITW 154
L + ++ A L +L P + + ++ I ++ V I C+ +G P P+I+W
Sbjct: 385 ---LAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISW 441
Query: 155 YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAP 214
K V K R DG L+I D G + C N G + L+V
Sbjct: 442 KKGDRAVRENK--RIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE-PT 498
Query: 215 NITRGPLDSTVIDGMSVVLACETSGAPRPAITWQ---KGERI---LASGSVQLPRFTPLE 268
I P + + G S+VL C+ +T+ KG+ I G + R
Sbjct: 499 RIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIR-AQAS 557
Query: 269 SGSLLISPTHISDAGTYTCLATNSRGVDEASADLVV 304
S L+I + AG Y C + A+L+V
Sbjct: 558 SADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLV 593
Score = 66.6 bits (161), Expect = 4e-11
Identities = 57/182 (31%), Positives = 83/182 (45%), Gaps = 15/182 (8%)
Query: 120 PQFVKEPERHI--TAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGL 177
P FV+EP+ I T EK V + C+ +G P PS W ++ +++E R+ DG
Sbjct: 25 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRY-SLIDGTF 83
Query: 178 QISG-LVPDDTGMFQCFARNAAGEV---QTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL 233
IS D+G +QC A N G + + + A TR + +V +G VVL
Sbjct: 84 IISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAV--SVREGQGVVL 141
Query: 234 ACE-TSGAPRPAITWQKGE--RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLAT 290
C +P +W E +A S RF E+G+L IS SD G+Y CL
Sbjct: 142 MCSPPPHSPEIIYSWVFNEFPSFVAEDS---RRFISQETGNLYISKVQTSDVGSYICLVK 198
Query: 291 NS 292
N+
Sbjct: 199 NT 200
Score = 40.0 bits (92), Expect = 0.004
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 7/76 (9%)
Query: 220 PLDSTVIDGMSVVLACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTH 278
P DS D V L CE G P P+ W + G I R++ ++ ++ +P+
Sbjct: 37 PTDS---DEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDY---RYSLIDGTFIISNPSE 90
Query: 279 ISDAGTYTCLATNSRG 294
D+G Y CLATN+ G
Sbjct: 91 AKDSGHYQCLATNTVG 106
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 106 bits (265), Expect = 3e-23
Identities = 89/310 (28%), Positives = 134/310 (43%), Gaps = 33/310 (10%)
Query: 45 WKIRPQGPTRPLIKLHIIWKKDGVLLSGGISD--HNRRLTIPNPTGSDAGYYECEAVLRS 102
+K +G P ++ W+KD L + + L I T D G Y C A
Sbjct: 242 FKCEARGDPVPTVR----WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA---E 294
Query: 103 SSVPSVVRGAYLSVL---EPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA 159
+ V A L+V EPP FV +P + A + + V C+A G P P+I W ++ +
Sbjct: 295 NMVGKAEASATLTVQVGSEPPHFVVKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGS 353
Query: 160 ------VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIA 213
+ +RF G L I+ + D G + C N AG + T YL VT +
Sbjct: 354 QNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 413
Query: 214 -----PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLE 268
P I +GP++ TV + VL+C +G+P P I W+K ++ S Q R LE
Sbjct: 414 ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLV---STQDSRIKQLE 470
Query: 269 SGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMV 328
+G L I + D G YTC+A+ G SA + V +PP + T +++
Sbjct: 471 NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP------RPTDPNLI 524
Query: 329 CGVTHDPRVT 338
P VT
Sbjct: 525 PSAPSKPEVT 534
Score = 93.6 bits (231), Expect = 3e-19
Identities = 73/233 (31%), Positives = 104/233 (44%), Gaps = 16/233 (6%)
Query: 119 PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR---NDG 175
PP+ V+ P I ++ E + C+A+G P P+I WYK VE +K R G
Sbjct: 28 PPRIVEHPSDLIVSKGEPAT-LNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 176 GLQISGLV-----PDDTGMFQCFARNAAGE-VQTSTYLAVTSIAPNITRGPLDSTVIDGM 229
L +V D G++ C ARN GE V + L V + + + P D V G
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 230 SVVLACE-TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 288
V+ C+ G P P I+W+K L ++ + G L+I+ T SDAG Y C+
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERI----TIRGGKLMITYTRKSDAGKYVCV 202
Query: 289 ATNSRGVDEAS-ADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIR 340
TN G E+ A+L V R K P + +V A C DP T+R
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVR 255
Score = 85.1 bits (209), Expect = 1e-16
Identities = 76/262 (29%), Positives = 111/262 (42%), Gaps = 15/262 (5%)
Query: 90 DAGYYECEAVLRSSSVPSVVRGAYLSV-LEPPQFVKEPERHITAEMEKVVDIPCQA-KGV 147
D G Y C V R+ +V A L V + F + P + A E V + CQ +G
Sbjct: 102 DEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAV-MECQPPRGH 158
Query: 148 PPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYL 207
P P+I+W KD + ++ +K R R G L I+ D G + C N GE ++
Sbjct: 159 PEPTISWKKDGSPLD-DKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVAE 216
Query: 208 AVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPL 267
P+ + P + V S CE G P P + W+K + G + R+
Sbjct: 217 LTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD-----GELPKSRYEIR 271
Query: 268 ESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWART---RITKPPQDQSVIKGTQ 324
+ +L I D G+YTC+A N G EASA L V + P+DQ V G
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRT 331
Query: 325 ASMVCGVTHDPRVTIRQLRPGA 346
+ C T +P+ I R G+
Sbjct: 332 VTFQCEATGNPQPAIFWRREGS 353
Score = 47.8 bits (112), Expect = 2e-05
Identities = 44/143 (30%), Positives = 52/143 (36%), Gaps = 9/143 (6%)
Query: 214 PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSL 272
P I P D V G L C+ G P P I W K GER+ L SGSL
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 273 LI-----SPTHISDAGTYTCLATNSRG--VDEASADLVVWARTRITKPPQDQSVIKGTQA 325
D G Y C+A N G V ++ V R + P D V G A
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 326 SMVCGVTH-DPRVTIRQLRPGAP 347
M C P TI + G+P
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSP 171
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,876,976
Number of Sequences: 37866
Number of extensions: 901073
Number of successful extensions: 6941
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 239
Number of HSP's successfully gapped in prelim test: 185
Number of HSP's that attempted gapping in prelim test: 2302
Number of HSP's gapped (non-prelim): 2134
length of query: 399
length of database: 18,247,518
effective HSP length: 104
effective length of query: 295
effective length of database: 14,309,454
effective search space: 4221288930
effective search space used: 4221288930
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.