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Search of human proteins with 110825982
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110825982 hect domain and RLD 5 [Homo sapiens]
(1024 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110825982 hect domain and RLD 5 [Homo sapiens] 2093 0.0
gi|61563742 hect domain and RLD 6 [Homo sapiens] 936 0.0
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 635 0.0
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 634 0.0
gi|7657152 hect domain and RLD 3 [Homo sapiens] 621 e-177
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 230 4e-60
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 230 4e-60
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 230 4e-60
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 201 3e-51
gi|222352183 neural precursor cell expressed, developmentally do... 167 5e-41
gi|21361472 neural precursor cell expressed, developmentally dow... 167 5e-41
gi|222352094 neural precursor cell expressed, developmentally do... 167 5e-41
gi|222352092 neural precursor cell expressed, developmentally do... 167 5e-41
gi|222352090 neural precursor cell expressed, developmentally do... 167 5e-41
gi|222352088 neural precursor cell expressed, developmentally do... 167 5e-41
gi|222352086 neural precursor cell expressed, developmentally do... 167 5e-41
gi|222352084 neural precursor cell expressed, developmentally do... 167 5e-41
gi|222352082 neural precursor cell expressed, developmentally do... 167 5e-41
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 166 1e-40
gi|114520609 neural precursor cell expressed, developmentally do... 164 5e-40
gi|114520607 neural precursor cell expressed, developmentally do... 164 5e-40
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 155 2e-37
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 155 2e-37
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 151 3e-36
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 147 5e-35
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 147 5e-35
gi|126032348 hect domain and RLD 2 [Homo sapiens] 144 4e-34
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 139 1e-32
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 137 7e-32
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 137 7e-32
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 2093 bits (5422), Expect = 0.0
Identities = 1024/1024 (100%), Positives = 1024/1024 (100%)
Query: 1 MERRSRRKSRRNGRSTAGKAAATQPAKSPGAQLWLFPSAAGLHRALLRRVEVTRQLCCSP 60
MERRSRRKSRRNGRSTAGKAAATQPAKSPGAQLWLFPSAAGLHRALLRRVEVTRQLCCSP
Sbjct: 1 MERRSRRKSRRNGRSTAGKAAATQPAKSPGAQLWLFPSAAGLHRALLRRVEVTRQLCCSP 60
Query: 61 GRLAVLERGGAGVQVHQLLAGSGGARTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFE 120
GRLAVLERGGAGVQVHQLLAGSGGARTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFE
Sbjct: 61 GRLAVLERGGAGVQVHQLLAGSGGARTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFE 120
Query: 121 YDNYSMKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTT 180
YDNYSMKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTT
Sbjct: 121 YDNYSMKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTT 180
Query: 181 TPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGL 240
TPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGL
Sbjct: 181 TPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGL 240
Query: 241 DNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQI 300
DNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQI
Sbjct: 241 DNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQI 300
Query: 301 ACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKE 360
ACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKE
Sbjct: 301 ACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKE 360
Query: 361 LIMIAGGNQSILLWIKKENSYVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFS 420
LIMIAGGNQSILLWIKKENSYVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFS
Sbjct: 361 LIMIAGGNQSILLWIKKENSYVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFS 420
Query: 421 SPACLTGSFLRKRRTTEMMPVYLDLNKARNIFKELTQKDWITNMITTCLKDNLLKRLPFH 480
SPACLTGSFLRKRRTTEMMPVYLDLNKARNIFKELTQKDWITNMITTCLKDNLLKRLPFH
Sbjct: 421 SPACLTGSFLRKRRTTEMMPVYLDLNKARNIFKELTQKDWITNMITTCLKDNLLKRLPFH 480
Query: 481 SPPQEALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFS 540
SPPQEALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFS
Sbjct: 481 SPPQEALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFS 540
Query: 541 KLVQMFKTAVICQLDYWDESAEENGNVQALLEMLKKLHRVNQVKCQLPESIFQVDELLHR 600
KLVQMFKTAVICQLDYWDESAEENGNVQALLEMLKKLHRVNQVKCQLPESIFQVDELLHR
Sbjct: 541 KLVQMFKTAVICQLDYWDESAEENGNVQALLEMLKKLHRVNQVKCQLPESIFQVDELLHR 600
Query: 601 LNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKA 660
LNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKA
Sbjct: 601 LNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKA 660
Query: 661 YLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGY 720
YLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGY
Sbjct: 661 YLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGY 720
Query: 721 DLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFN 780
DLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFN
Sbjct: 721 DLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFN 780
Query: 781 CNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHW 840
CNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHW
Sbjct: 781 CNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHW 840
Query: 841 DRNDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLF 900
DRNDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLF
Sbjct: 841 DRNDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLF 900
Query: 901 HPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLT 960
HPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLT
Sbjct: 901 HPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLT 960
Query: 961 GTDRLQMKDLNNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNN 1020
GTDRLQMKDLNNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNN
Sbjct: 961 GTDRLQMKDLNNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNN 1020
Query: 1021 RGFG 1024
RGFG
Sbjct: 1021 RGFG 1024
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 936 bits (2418), Expect = 0.0
Identities = 504/1017 (49%), Positives = 671/1017 (65%), Gaps = 39/1017 (3%)
Query: 26 AKSPGAQLWLFPSAAGLHRALLRRVEVTRQLCCSPGRLAVLERGGAGVQVHQLLAGSGGA 85
A SPGA+L +A+G +LL R L C L R GA
Sbjct: 18 AGSPGAEL--LQAASGERHSLLLLTN-HRVLSCGDNSRGQLGRRGAQ-----------RG 63
Query: 86 RTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHL---RFESI-------- 134
P+ I+ + + + V G EH L + G+ F + S L F+ I
Sbjct: 64 ELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIM 123
Query: 135 -LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPL 193
L + KIIQ++CG YHSLALSK ++F+WG+N HGQLG+G++FPS +PQ V L G+PL
Sbjct: 124 TLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPL 183
Query: 194 AQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTE---SKDDPSLIEGLDNQKVEFVAC 250
AQ++AG AHS ALS+ G + WG N GQL L + P + L N V +++C
Sbjct: 184 AQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISC 243
Query: 251 GGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAY 310
G +H+A+LTQDG +FTFG + GQLG++ T + P LV + G V+QI CG +HTLAY
Sbjct: 244 GDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGSYHTLAY 302
Query: 311 VSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGGNQS 370
V G+V SFG G + T + + +S + E + + AG +
Sbjct: 303 VHTTGQVVSFGHGPSDT--SKPTHPEALTENFDISCL--ISAEDFVDVQVKHIFAGTYAN 358
Query: 371 ILLWIKKENSYVNLKRTIPTLN---EGTVKRWIA-DVETKRWQSTKREIQEIFSSPACLT 426
+ + +S +T+P ++ + ++WIA + + K EI+ IFSSPACLT
Sbjct: 359 FVTTHQDTSSTRAPGKTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFSSPACLT 418
Query: 427 GSFLRKRRTTEMMPVYLDLNKARNIFKELTQKDWITNMITTCLKDNLLKRLPFHSPPQEA 486
SFL+KR T E + +DL AR+ FK+LT+K+WI++MITTCL+D+LL+ LP HSP QEA
Sbjct: 419 ASFLKKRGTGETTSIDVDLEMARDTFKKLTKKEWISSMITTCLEDDLLRALPCHSPHQEA 478
Query: 487 LEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFSKLVQMF 546
L +F LLPECP+MH S NW++LVVPFAK VC+MS QS VL++ WA LQES+ + L+QM
Sbjct: 479 LSVFLLLPECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQML 538
Query: 547 KTAVICQLDYWDESAEENGNVQALLEMLKKLHRVNQVKCQLPESIFQVDELLHRLNFFVE 606
K A+I QL + ++ +++ NV+ALL M+K+LH+VN+ C+LPE+ F ++EL + LNF+++
Sbjct: 539 KAAIISQLLHQTKTEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINELSNLLNFYID 598
Query: 607 VCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAA 666
R+ + +E VIFS FPFIFN+LSKIKLL D+ +K++ + KAY+
Sbjct: 599 RGRQLFRDNHLIPAETPSP-VIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHE 657
Query: 667 IEEERESEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVK 726
+++ EF P F L VRR+ L++D L QLSQ E D K L V F EI + GGV
Sbjct: 658 TILQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVS 717
Query: 727 KEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANL 786
EFF+C+F EM +PEYGMFMYPE SCMWFP KPK EKKRYF FG+LCGLSLFN NVANL
Sbjct: 718 SEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANL 777
Query: 787 PFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTN 846
PFPLAL+KKLLDQ PSLEDLKELSP LGK+LQ +LDD D+ + I F++HWD+ND +
Sbjct: 778 PFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWDQNDVD 837
Query: 847 LIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELK 906
LIPNG SI V+QTNKRDYVSKYI+YIFN SVKAVYEEF+RGFY++C+++I++ F+PEEL
Sbjct: 838 LIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELM 897
Query: 907 DVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQ 966
I+GNTDYDWK FE+N++YE GY SHPTI +FWKAFHKLTL+EKKKFL FLTG DRL
Sbjct: 898 TAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLH 957
Query: 967 MKDLNNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+ + M+I F CPE+++ERD ++TC ++L LPKYSTME +EEALQ AINNNRGF
Sbjct: 958 ARGIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 635 bits (1638), Expect = 0.0
Identities = 349/927 (37%), Positives = 544/927 (58%), Gaps = 44/927 (4%)
Query: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194
L + +I+Q+ CG YHSLALSK E+F WGQN +GQLG+G T+PQ+++ L G+P
Sbjct: 134 LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFM 193
Query: 195 QISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSH 254
Q++AG AHS L++SG I+ WG+N+ GQLGL + P+L++ L +QK+ ++ CG H
Sbjct: 194 QVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDH 253
Query: 255 SALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDL 314
+A LT++G +FTFGAG +GQLGHNST +E+ P V EL+G VT+IACGR HT A+V
Sbjct: 254 TAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSS 313
Query: 315 GKVFSFGSGKDGQLGNGGTRDQLMPLPVKVS-------SSEELKLESHTSEKELIMIAGG 367
G+++SFG G +GQLG G T ++ P VK + ++ E + K + +GG
Sbjct: 314 GRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKRI--FSGG 371
Query: 368 NQSILLWIKKEN-------SYVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFS 420
+QS + +N N + I T+NE +++W++ + EI FS
Sbjct: 372 DQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFS 431
Query: 421 SPACLTGSFL------RKRRTTEMMPVYLDLNKARNIFKELTQKD--WITNMITTCLKDN 472
S CL GSFL R T V D+N AR +F +L Q D I+ + L+ N
Sbjct: 432 SSGCLNGSFLAVSNDDHYRTGTRFSGV--DMNAARLLFHKLIQPDHPQISQQVAASLEKN 489
Query: 473 LLKRLPFHSPPQEALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWA 532
L+ +L P EAL + LPECP+M SNN+ ++ +PF + + VLE +W+
Sbjct: 490 LIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWS 549
Query: 533 TLQESTFSKLVQMFKTAVICQLDYW------DESAEENGNVQALLEMLKKLHRVNQVKCQ 586
L+ F K+V++FK V+ L + E N + L++L+ LHRVN+ Q
Sbjct: 550 VLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQ 609
Query: 587 LPE----SIFQVDELLHRLNFFVEVCRRYLWKMTVD--ASENVQCCVIFSHFPFIFNNLS 640
+ + I +V EL+ N ++ ++ + M V+ +E V +PF+F+ +
Sbjct: 610 IIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQA 669
Query: 641 KIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQLSQ 700
K LL TD +L+++ +A+ ++ + E ++ P L VRR +++ D + L +
Sbjct: 670 KTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIE-SVNPCLILVVRRENIVGDAMEVLRK 728
Query: 701 FENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKP 760
+N D +K L V F GE D GGV+KEFF + E++ P+YGMF Y E + +WF K
Sbjct: 729 TKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKT 788
Query: 761 KFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTL 820
+ + GV+CGL+++NC + +L FPLAL+KKLL + PSL+DLKEL PD+G+++Q L
Sbjct: 789 FEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQL 848
Query: 821 LDDEGDNFEEVFYIHFNVHWDR----NDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDS 876
LD D+ EE F ++F + + L+ NG+ VN+ N++++V Y++YIFN S
Sbjct: 849 LDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKS 908
Query: 877 VKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPT 936
V ++++ F GF+K+C ++ LF P EL+ +++GNT+YDWK EKN Y+ Y + HPT
Sbjct: 909 VASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPT 968
Query: 937 IVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNERDPIRALTCFS 996
I +FW+ FH+L LE+KK+FL+FLTG+DR+ + + ++K+ E P+ + TCF+
Sbjct: 969 IKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPV-SHTCFN 1027
Query: 997 VLFLPKYSTMETVEEALQEAINNNRGF 1023
+L LPKY+ ET+ L +AI++N GF
Sbjct: 1028 LLDLPKYTEKETLRSKLIQAIDHNEGF 1054
Score = 91.3 bits (225), Expect = 4e-18
Identities = 55/175 (31%), Positives = 89/175 (50%), Gaps = 5/175 (2%)
Query: 159 LFAWGQNLHGQLGVGR-KFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGK 217
+ WG GQLG+G P+ + + + G H++ + G +Y+ G
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 218 NECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGH 277
N+ GQ LGH +S+ P + LD Q + V+CG +H+ L G ++ +G GQLG
Sbjct: 61 NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118
Query: 278 NSTQNELR-PCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNG 331
++ +R P + L ++ Q+ACG +H+LA +S +VF +G K GQLG G
Sbjct: 119 VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLA-LSKASEVFCWGQNKYGQLGLG 172
Score = 78.6 bits (192), Expect = 3e-14
Identities = 45/140 (32%), Positives = 77/140 (55%), Gaps = 6/140 (4%)
Query: 215 WGKNECGQLGLGHTESKD--DPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKH 272
WG GQLGLG + + +P + N++V V CG H+ + DG ++T G
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 273 GQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGG 332
GQLGH ++ +P V L + ++CG HTLA ++D G+V+++G DGQLG G
Sbjct: 64 GQLGHEKSRK--KPEQVVALDAQNIVAVSCGEAHTLA-LNDKGQVYAWGLDSDGQLGLVG 120
Query: 333 TRDQLMPLPVKVSSSEELKL 352
+ ++ + +P + S ++++
Sbjct: 121 S-EECIRVPRNIKSLSDIQI 139
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 634 bits (1635), Expect = 0.0
Identities = 348/925 (37%), Positives = 541/925 (58%), Gaps = 48/925 (5%)
Query: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194
L + +I+Q+ CG YHSLALSK E+F WGQN +GQLG+G T+PQ+++ L G+P
Sbjct: 134 LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFM 193
Query: 195 QISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSH 254
Q++AG AHS L++SG I+ WG+N+ GQLGL + P+L++ L +QK+ ++ CG H
Sbjct: 194 QVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDH 253
Query: 255 SALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDL 314
+A LT++G +FTFGAG +GQLGHNST +E+ P V EL+G VT+IACGR HT A+V
Sbjct: 254 TAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSS 313
Query: 315 GKVFSFGSGKDGQLGNGGTRDQLMPLPVKVS-------SSEELKLESHTSEKELIMIAGG 367
G+++SFG G +GQLG G T ++ P VK + ++ E + K + +GG
Sbjct: 314 GRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKRI--FSGG 371
Query: 368 NQSILLWIKKEN-------SYVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFS 420
+QS + +N N + I T+NE +++W++ + EI FS
Sbjct: 372 DQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFS 431
Query: 421 SPACLTGSFL------RKRRTTEMMPVYLDLNKARNIFKELTQKD--WITNMITTCLKDN 472
S CL GSFL R T V D+N AR +F +L Q D I+ + L+ N
Sbjct: 432 SSGCLNGSFLAVSNDDHYRTGTRFSGV--DMNAARLLFHKLIQPDHPQISQQVAASLEKN 489
Query: 473 LLKRLPFHSPPQEALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWA 532
L+ +L P EAL + LPECP+M SNN+ ++ +PF + + VLE +W+
Sbjct: 490 LIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWS 549
Query: 533 TLQESTFSKLVQMFKTAVICQLDYW------DESAEENGNVQALLEMLKKLHRVNQVKCQ 586
L+ F K+V++FK V+ L + E N + L++L+ LHRVN+ Q
Sbjct: 550 VLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQ 609
Query: 587 LPE----SIFQVDELLHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKI 642
+ + I +V EL+ N ++ ++ + M D V +PF+F+ +K
Sbjct: 610 IIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLADIP------VTICTYPFVFDAQAKT 663
Query: 643 KLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQLSQFE 702
LL TD +L+++ +A+ ++ + E ++ P L VRR +++ D + L + +
Sbjct: 664 TLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIE-SVNPCLILVVRRENIVGDAMEVLRKTK 722
Query: 703 NEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKF 762
N D +K L V F GE D GGV+KEFF + E++ P+YGMF Y E + +WF K
Sbjct: 723 NIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFE 782
Query: 763 EKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLD 822
+ + GV+CGL+++NC + +L FPLAL+KKLL + PSL+DLKEL PD+G+++Q LLD
Sbjct: 783 DSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLD 842
Query: 823 DEGDNFEEVFYIHFNVHWDR----NDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVK 878
D+ EE F ++F + + L+ NG+ VN+ N++++V Y++YIFN SV
Sbjct: 843 YPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVA 902
Query: 879 AVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIV 938
++++ F GF+K+C ++ LF P EL+ +++GNT+YDWK EKN Y+ Y + HPTI
Sbjct: 903 SLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIK 962
Query: 939 MFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNERDPIRALTCFSVL 998
+FW+ FH+L LE+KK+FL+FLTG+DR+ + + ++K+ E P+ + TCF++L
Sbjct: 963 IFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPV-SHTCFNLL 1021
Query: 999 FLPKYSTMETVEEALQEAINNNRGF 1023
LPKY+ ET+ L +AI++N GF
Sbjct: 1022 DLPKYTEKETLRSKLIQAIDHNEGF 1046
Score = 91.3 bits (225), Expect = 4e-18
Identities = 55/175 (31%), Positives = 89/175 (50%), Gaps = 5/175 (2%)
Query: 159 LFAWGQNLHGQLGVGR-KFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGK 217
+ WG GQLG+G P+ + + + G H++ + G +Y+ G
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 218 NECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGH 277
N+ GQ LGH +S+ P + LD Q + V+CG +H+ L G ++ +G GQLG
Sbjct: 61 NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118
Query: 278 NSTQNELR-PCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNG 331
++ +R P + L ++ Q+ACG +H+LA +S +VF +G K GQLG G
Sbjct: 119 VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLA-LSKASEVFCWGQNKYGQLGLG 172
Score = 78.6 bits (192), Expect = 3e-14
Identities = 45/140 (32%), Positives = 77/140 (55%), Gaps = 6/140 (4%)
Query: 215 WGKNECGQLGLGHTESKD--DPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKH 272
WG GQLGLG + + +P + N++V V CG H+ + DG ++T G
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 273 GQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGG 332
GQLGH ++ +P V L + ++CG HTLA ++D G+V+++G DGQLG G
Sbjct: 64 GQLGHEKSRK--KPEQVVALDAQNIVAVSCGEAHTLA-LNDKGQVYAWGLDSDGQLGLVG 120
Query: 333 TRDQLMPLPVKVSSSEELKL 352
+ ++ + +P + S ++++
Sbjct: 121 S-EECIRVPRNIKSLSDIQI 139
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 621 bits (1601), Expect = e-177
Identities = 354/958 (36%), Positives = 550/958 (57%), Gaps = 41/958 (4%)
Query: 105 GAEHMLILSSDGKPFEYDNYSMKHL------------RFESILQEKKIIQITCGDYHSLA 152
G H L LS G+ F + S L R L ++ I+Q++CG++H LA
Sbjct: 92 GESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLA 151
Query: 153 LSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNI 212
L+ G+ F WG+N HGQLG+G++FPS +PQ V L G+PLAQ++AG AHS ALS+SG +
Sbjct: 152 LAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAV 211
Query: 213 YSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKH 272
+ WG N GQLGL + ++ P ++ L QKV +++CG H+A+LT+ G +FTFGAG
Sbjct: 212 FGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSC 271
Query: 273 GQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGG 332
GQLGH+S +E+ P V EL+G VTQIACGR HTLA+V G +++FG G GQLG G
Sbjct: 272 GQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGH 331
Query: 333 TRDQLMPLPVK---VSSSEELKLESHTSEKELI--MIAGGNQSILLWIKKEN-------S 380
T + P PVK + S +L + + ++ + +GG+Q+ +L K EN
Sbjct: 332 TCNVKCPSPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAVDFR 391
Query: 381 YVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFSSPACLTGSFLRKR-----RT 435
+N +N+ T+ W + +T + +I SS AC GSFL K+ +T
Sbjct: 392 TMNQAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILSSAACWNGSFLEKKIDEHFKT 451
Query: 436 TEMMPVYLDLNKARNIFKEL--TQKDWITNMITTCLKDNLLKRLPFHSPPQEALEIFFLL 493
+ +P +DLN R +F++L +Q I I + L+ +L P EA+ I+ +L
Sbjct: 452 SPKIP-GIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYLIL 510
Query: 494 PECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFSKLVQMFKTAVICQ 553
PE P++ S + +L +P A + ++ S VL+ +W+ + F KLV ++K AV+
Sbjct: 511 PEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGAVLYL 570
Query: 554 L---DYWDESAEENGNVQALLEMLKKLHRVNQVKCQLPESIFQVDELLHRLNFFVEVCRR 610
L + N + A L++L+KL++VN + F + E+ + ++ +
Sbjct: 571 LRGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMW 630
Query: 611 YLWKMTVDASEN-VQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEE 669
+L + + A + +Q V +PFIF+ +K K+L TD L+++ + A L++ +
Sbjct: 631 FLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLL 690
Query: 670 ERESEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEF 729
E A P L VRRN+L+ D L +LS + DL+K L V F GE D GGV KEF
Sbjct: 691 TLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEF 750
Query: 730 FYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFP 789
F L E++ P YGMF Y + ++ +WF E + G+ CGL+++N V +L FP
Sbjct: 751 FLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFP 810
Query: 790 LALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDR----NDT 845
LAL+KKLL+ P LEDLKELSP G++LQ LLD G++ EE F ++F + +
Sbjct: 811 LALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQK 870
Query: 846 NLIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEEL 905
LIP G ++TV + N++++V Y+NY+F SV Y F GF K+C +++LF P EL
Sbjct: 871 KLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSEL 930
Query: 906 KDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRL 965
+ ++VGN++Y+W+ E+ A Y+ Y+++HPT+ +FW+ FH+ LE+KKKFL+FLTG+DR+
Sbjct: 931 RAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRI 990
Query: 966 QMKDLNNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+ + +++I S E P+ A TC+++L LPKYS+ E + L +A++N GF
Sbjct: 991 PIYGMASLQIVIQSTASGEEYLPV-AHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
Score = 128 bits (321), Expect = 3e-29
Identities = 81/235 (34%), Positives = 122/235 (51%), Gaps = 6/235 (2%)
Query: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194
+ ++ + ++ CG HS+ L + GE++ G N GQLG R+ P+ + LA +
Sbjct: 31 ISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHERE---GNKPEQIGALADQHII 87
Query: 195 QISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTE-SKDDPSLIEGLDNQKVEFVACGGS 253
++ GE+HS+ALS G ++SWG GQLGL TE S P LI+ L+ Q + V+CG
Sbjct: 88 HVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNW 147
Query: 254 HSALLTQDGLLFTFGAGKHGQLG-HNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVS 312
H L DG FT+G HGQLG ++ P V L G + Q+A G H+ A +S
Sbjct: 148 HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA-LS 206
Query: 313 DLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGG 367
G VF +G GQLG +D+ P VK+ ++++ S E ++ G
Sbjct: 207 LSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSG 261
Score = 106 bits (265), Expect = 1e-22
Identities = 62/175 (35%), Positives = 93/175 (53%), Gaps = 5/175 (2%)
Query: 159 LFAWGQNLHGQLGVGRKFPSTTT-PQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGK 217
+ WG GQ G+ PQ+ ++ + +++ G HS+ L G +Y+ G
Sbjct: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
Query: 218 NECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGH 277
N GQ LGH + P I L +Q + VACG SHS L+ G LF++GAG GQLG
Sbjct: 61 NTKGQ--LGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGL 118
Query: 278 NSTQNELR-PCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNG 331
+T++ + P L+ +L + Q++CG WH LA +D G+ F++G GQLG G
Sbjct: 119 MTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAAD-GQFFTWGKNSHGQLGLG 172
Score = 85.5 bits (210), Expect = 2e-16
Identities = 54/178 (30%), Positives = 87/178 (48%), Gaps = 6/178 (3%)
Query: 215 WGKNECGQLGLGHTESK--DDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKH 272
WG GQ G+ +P + + ++ V+ VACGG+HS L +DG ++T G
Sbjct: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63
Query: 273 GQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGG 332
GQLGH N +P + L + +ACG H+LA +SD G++FS+G+G DGQLG
Sbjct: 64 GQLGHEREGN--KPEQIGALADQHIIHVACGESHSLA-LSDRGQLFSWGAGSDGQLGLMT 120
Query: 333 TRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGGNQSILLWIKKENSYVNLKRTIPT 390
T D + + +++ L+ + +A Q W K + + L + P+
Sbjct: 121 TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQ-FFTWGKNSHGQLGLGKEFPS 177
Score = 44.3 bits (103), Expect = 6e-04
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 12/99 (12%)
Query: 87 TPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFESI-----------L 135
+P +KL + K+ + G EH +L+ G F + S L +S+ L
Sbjct: 232 SPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLEL 291
Query: 136 QEKKIIQITCGDYHSLA-LSKGGELFAWGQNLHGQLGVG 173
++ QI CG H+LA + G ++A+G GQLG G
Sbjct: 292 MGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTG 330
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 230 bits (587), Expect = 4e-60
Identities = 148/458 (32%), Positives = 245/458 (53%), Gaps = 31/458 (6%)
Query: 580 VNQVKCQLPESIFQVDELLHR-LNFFVEVCRRY-LWKMTVDASENVQCCVIFSHFPFIFN 637
V + C+ P + +E ++ LN +E+ + Y +K+ + + C PFI N
Sbjct: 431 VKTLDCRKP--LIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTC------PFILN 482
Query: 638 NLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQ 697
++K L+ D +++ S++ L S ++ L P L VRR+H+I+D L +
Sbjct: 483 AVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQ------LNPYLRLKVRRDHIIDDALVR 536
Query: 698 LSQFENE---DLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCM 754
L E DL+K+L+V F GE G D GGV KEFF + E+ P+ GMF Y E
Sbjct: 537 LEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLF 596
Query: 755 WFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLG 814
WF + ++ G++ GL+++N + ++ FP+ +++KL+ + + DL + P L
Sbjct: 597 WFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLY 656
Query: 815 KNLQTLLDDEGDNFEEVFYIHFNVHWDRNDT-------NLIPNGSSITVNQTNKRDYVSK 867
++L+ LL+ EG N E+ I F + + D +L NG I + N++++V+
Sbjct: 657 QSLKDLLEYEG-NVEDDMMITFQI--SQTDLFGNPMMYDLKENGDKIPITNENRKEFVNL 713
Query: 868 YINYIFNDSVKAVYEEFRRGFYKMCDEDIIK-LFHPEELKDVIVGNTDYDWKTFEKNARY 926
Y +YI N SV+ ++ FRRGF+ + +E +K LF PEE++ +I G+ + D++ E+ Y
Sbjct: 714 YSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY 773
Query: 927 EPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNER 986
+ GY I FW+ H T E+K+ FL F TGTDR + L +K+ ER
Sbjct: 774 DGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTER 833
Query: 987 DPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG 1024
P + TCF+VL LP+YS+ E ++E L +AI +GFG
Sbjct: 834 LP-TSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFG 870
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 230 bits (587), Expect = 4e-60
Identities = 148/458 (32%), Positives = 245/458 (53%), Gaps = 31/458 (6%)
Query: 580 VNQVKCQLPESIFQVDELLHR-LNFFVEVCRRY-LWKMTVDASENVQCCVIFSHFPFIFN 637
V + C+ P + +E ++ LN +E+ + Y +K+ + + C PFI N
Sbjct: 411 VKTLDCRKP--LIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTC------PFILN 462
Query: 638 NLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQ 697
++K L+ D +++ S++ L S ++ L P L VRR+H+I+D L +
Sbjct: 463 AVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQ------LNPYLRLKVRRDHIIDDALVR 516
Query: 698 LSQFENE---DLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCM 754
L E DL+K+L+V F GE G D GGV KEFF + E+ P+ GMF Y E
Sbjct: 517 LEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLF 576
Query: 755 WFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLG 814
WF + ++ G++ GL+++N + ++ FP+ +++KL+ + + DL + P L
Sbjct: 577 WFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLY 636
Query: 815 KNLQTLLDDEGDNFEEVFYIHFNVHWDRNDT-------NLIPNGSSITVNQTNKRDYVSK 867
++L+ LL+ EG N E+ I F + + D +L NG I + N++++V+
Sbjct: 637 QSLKDLLEYEG-NVEDDMMITFQI--SQTDLFGNPMMYDLKENGDKIPITNENRKEFVNL 693
Query: 868 YINYIFNDSVKAVYEEFRRGFYKMCDEDIIK-LFHPEELKDVIVGNTDYDWKTFEKNARY 926
Y +YI N SV+ ++ FRRGF+ + +E +K LF PEE++ +I G+ + D++ E+ Y
Sbjct: 694 YSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY 753
Query: 927 EPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNER 986
+ GY I FW+ H T E+K+ FL F TGTDR + L +K+ ER
Sbjct: 754 DGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTER 813
Query: 987 DPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG 1024
P + TCF+VL LP+YS+ E ++E L +AI +GFG
Sbjct: 814 LP-TSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFG 850
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 230 bits (587), Expect = 4e-60
Identities = 148/458 (32%), Positives = 245/458 (53%), Gaps = 31/458 (6%)
Query: 580 VNQVKCQLPESIFQVDELLHR-LNFFVEVCRRY-LWKMTVDASENVQCCVIFSHFPFIFN 637
V + C+ P + +E ++ LN +E+ + Y +K+ + + C PFI N
Sbjct: 434 VKTLDCRKP--LIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTC------PFILN 485
Query: 638 NLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQ 697
++K L+ D +++ S++ L S ++ L P L VRR+H+I+D L +
Sbjct: 486 AVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQ------LNPYLRLKVRRDHIIDDALVR 539
Query: 698 LSQFENE---DLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCM 754
L E DL+K+L+V F GE G D GGV KEFF + E+ P+ GMF Y E
Sbjct: 540 LEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLF 599
Query: 755 WFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLG 814
WF + ++ G++ GL+++N + ++ FP+ +++KL+ + + DL + P L
Sbjct: 600 WFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLY 659
Query: 815 KNLQTLLDDEGDNFEEVFYIHFNVHWDRNDT-------NLIPNGSSITVNQTNKRDYVSK 867
++L+ LL+ EG N E+ I F + + D +L NG I + N++++V+
Sbjct: 660 QSLKDLLEYEG-NVEDDMMITFQI--SQTDLFGNPMMYDLKENGDKIPITNENRKEFVNL 716
Query: 868 YINYIFNDSVKAVYEEFRRGFYKMCDEDIIK-LFHPEELKDVIVGNTDYDWKTFEKNARY 926
Y +YI N SV+ ++ FRRGF+ + +E +K LF PEE++ +I G+ + D++ E+ Y
Sbjct: 717 YSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY 776
Query: 927 EPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNER 986
+ GY I FW+ H T E+K+ FL F TGTDR + L +K+ ER
Sbjct: 777 DGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTER 836
Query: 987 DPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG 1024
P + TCF+VL LP+YS+ E ++E L +AI +GFG
Sbjct: 837 LP-TSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFG 873
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 201 bits (511), Expect = 3e-51
Identities = 122/414 (29%), Positives = 214/414 (51%), Gaps = 25/414 (6%)
Query: 629 FSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRN 688
F +PF+ + +K ++ D+ ++ + ++ + + + + ++ VRR
Sbjct: 368 FCQYPFVISVAAKKIIIQRDSEQQMINIARQSLVDKVSRRQRPDMNILF---LNMKVRRT 424
Query: 689 HLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYP 748
HL+ D L++L++ + DL+K+L V+F GE G D+GG+ KE+F L ++ P+YGMF Y
Sbjct: 425 HLVSDSLDELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYH 483
Query: 749 EGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQ--MPS---- 802
+ + C WF + G+L GL+++N ++ FP +KKLL +PS
Sbjct: 484 KDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNI 543
Query: 803 --------LEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDR----NDTNLIPN 850
++DL ++ P+L L LL EG N EE FY F V + NL P
Sbjct: 544 PVGICNVTVDDLCQIMPELAHGLSELLSHEG-NVEEDFYSTFQVFQEEFGIIKSYNLKPG 602
Query: 851 GSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIV 910
G I+V N+++YV Y +++ N S+ + F GF+ +C + + L PEE++ ++
Sbjct: 603 GDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVC 662
Query: 911 GNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDL 970
G+ D D +++ +Y+ GY + TI FW L+ +KK L F TG+DR+ + +
Sbjct: 663 GSPDLDMHALQRSTQYD-GYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGM 721
Query: 971 NNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG 1024
++ E+ P+ A TCF+ L LP Y + + +++ L I+N+ GFG
Sbjct: 722 ADLNFKISKNETSTNCLPV-AHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFG 774
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 167 bits (423), Expect = 5e-41
Identities = 107/356 (30%), Positives = 178/356 (50%), Gaps = 15/356 (4%)
Query: 681 FDLTVRRNHLIEDVLNQLSQFENED-LRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQ 739
F++ + RN++ E+ ++ + D L+ LW+ F E G D GGV +E+F+ L EM
Sbjct: 497 FEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556
Query: 740 PEYGMFMYPEGASCMWFPVKPKF-----EKKRYF-FFGVLCGLSLFNCNVANLPFPLALF 793
P YG+F Y + P + YF F G + GL++F+ + + F +
Sbjct: 557 PYYGLFEY-SATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFY 615
Query: 794 KKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSS 853
K +L + +L D++ + + +L+ +L+++ + +F I +L PNGS
Sbjct: 616 KMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSE 675
Query: 854 ITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNT 913
I V NKR+Y+ I + F + V+ F GF ++ D+IK+F EL+ ++ G
Sbjct: 676 IMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG 735
Query: 914 DYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDL--- 970
D D + +++ Y+ GY +HP I FWKA + E++ + L F+TGT R+ M
Sbjct: 736 DVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAEL 795
Query: 971 --NNMKITFCCPESWNERDPI-RALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+N F E W + + RA TCF+ L LP Y T E + E L A+ N +GF
Sbjct: 796 YGSNGPQLFTI-EQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 167 bits (423), Expect = 5e-41
Identities = 107/356 (30%), Positives = 178/356 (50%), Gaps = 15/356 (4%)
Query: 681 FDLTVRRNHLIEDVLNQLSQFENED-LRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQ 739
F++ + RN++ E+ ++ + D L+ LW+ F E G D GGV +E+F+ L EM
Sbjct: 598 FEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 657
Query: 740 PEYGMFMYPEGASCMWFPVKPKF-----EKKRYF-FFGVLCGLSLFNCNVANLPFPLALF 793
P YG+F Y + P + YF F G + GL++F+ + + F +
Sbjct: 658 PYYGLFEY-SATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFY 716
Query: 794 KKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSS 853
K +L + +L D++ + + +L+ +L+++ + +F I +L PNGS
Sbjct: 717 KMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSE 776
Query: 854 ITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNT 913
I V NKR+Y+ I + F + V+ F GF ++ D+IK+F EL+ ++ G
Sbjct: 777 IMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG 836
Query: 914 DYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDL--- 970
D D + +++ Y+ GY +HP I FWKA + E++ + L F+TGT R+ M
Sbjct: 837 DVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAEL 896
Query: 971 --NNMKITFCCPESWNERDPI-RALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+N F E W + + RA TCF+ L LP Y T E + E L A+ N +GF
Sbjct: 897 YGSNGPQLFTI-EQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 167 bits (423), Expect = 5e-41
Identities = 107/356 (30%), Positives = 178/356 (50%), Gaps = 15/356 (4%)
Query: 681 FDLTVRRNHLIEDVLNQLSQFENED-LRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQ 739
F++ + RN++ E+ ++ + D L+ LW+ F E G D GGV +E+F+ L EM
Sbjct: 477 FEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 536
Query: 740 PEYGMFMYPEGASCMWFPVKPKF-----EKKRYF-FFGVLCGLSLFNCNVANLPFPLALF 793
P YG+F Y + P + YF F G + GL++F+ + + F +
Sbjct: 537 PYYGLFEY-SATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFY 595
Query: 794 KKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSS 853
K +L + +L D++ + + +L+ +L+++ + +F I +L PNGS
Sbjct: 596 KMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSE 655
Query: 854 ITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNT 913
I V NKR+Y+ I + F + V+ F GF ++ D+IK+F EL+ ++ G
Sbjct: 656 IMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG 715
Query: 914 DYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDL--- 970
D D + +++ Y+ GY +HP I FWKA + E++ + L F+TGT R+ M
Sbjct: 716 DVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAEL 775
Query: 971 --NNMKITFCCPESWNERDPI-RALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+N F E W + + RA TCF+ L LP Y T E + E L A+ N +GF
Sbjct: 776 YGSNGPQLFTI-EQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 167 bits (423), Expect = 5e-41
Identities = 107/356 (30%), Positives = 178/356 (50%), Gaps = 15/356 (4%)
Query: 681 FDLTVRRNHLIEDVLNQLSQFENED-LRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQ 739
F++ + RN++ E+ ++ + D L+ LW+ F E G D GGV +E+F+ L EM
Sbjct: 477 FEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 536
Query: 740 PEYGMFMYPEGASCMWFPVKPKF-----EKKRYF-FFGVLCGLSLFNCNVANLPFPLALF 793
P YG+F Y + P + YF F G + GL++F+ + + F +
Sbjct: 537 PYYGLFEY-SATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFY 595
Query: 794 KKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSS 853
K +L + +L D++ + + +L+ +L+++ + +F I +L PNGS
Sbjct: 596 KMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSE 655
Query: 854 ITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNT 913
I V NKR+Y+ I + F + V+ F GF ++ D+IK+F EL+ ++ G
Sbjct: 656 IMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG 715
Query: 914 DYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDL--- 970
D D + +++ Y+ GY +HP I FWKA + E++ + L F+TGT R+ M
Sbjct: 716 DVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAEL 775
Query: 971 --NNMKITFCCPESWNERDPI-RALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+N F E W + + RA TCF+ L LP Y T E + E L A+ N +GF
Sbjct: 776 YGSNGPQLFTI-EQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 167 bits (423), Expect = 5e-41
Identities = 107/356 (30%), Positives = 178/356 (50%), Gaps = 15/356 (4%)
Query: 681 FDLTVRRNHLIEDVLNQLSQFENED-LRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQ 739
F++ + RN++ E+ ++ + D L+ LW+ F E G D GGV +E+F+ L EM
Sbjct: 590 FEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 649
Query: 740 PEYGMFMYPEGASCMWFPVKPKF-----EKKRYF-FFGVLCGLSLFNCNVANLPFPLALF 793
P YG+F Y + P + YF F G + GL++F+ + + F +
Sbjct: 650 PYYGLFEY-SATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFY 708
Query: 794 KKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSS 853
K +L + +L D++ + + +L+ +L+++ + +F I +L PNGS
Sbjct: 709 KMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSE 768
Query: 854 ITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNT 913
I V NKR+Y+ I + F + V+ F GF ++ D+IK+F EL+ ++ G
Sbjct: 769 IMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG 828
Query: 914 DYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDL--- 970
D D + +++ Y+ GY +HP I FWKA + E++ + L F+TGT R+ M
Sbjct: 829 DVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAEL 888
Query: 971 --NNMKITFCCPESWNERDPI-RALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+N F E W + + RA TCF+ L LP Y T E + E L A+ N +GF
Sbjct: 889 YGSNGPQLFTI-EQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 167 bits (423), Expect = 5e-41
Identities = 107/356 (30%), Positives = 178/356 (50%), Gaps = 15/356 (4%)
Query: 681 FDLTVRRNHLIEDVLNQLSQFENED-LRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQ 739
F++ + RN++ E+ ++ + D L+ LW+ F E G D GGV +E+F+ L EM
Sbjct: 610 FEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 669
Query: 740 PEYGMFMYPEGASCMWFPVKPKF-----EKKRYF-FFGVLCGLSLFNCNVANLPFPLALF 793
P YG+F Y + P + YF F G + GL++F+ + + F +
Sbjct: 670 PYYGLFEY-SATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFY 728
Query: 794 KKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSS 853
K +L + +L D++ + + +L+ +L+++ + +F I +L PNGS
Sbjct: 729 KMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSE 788
Query: 854 ITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNT 913
I V NKR+Y+ I + F + V+ F GF ++ D+IK+F EL+ ++ G
Sbjct: 789 IMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG 848
Query: 914 DYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDL--- 970
D D + +++ Y+ GY +HP I FWKA + E++ + L F+TGT R+ M
Sbjct: 849 DVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAEL 908
Query: 971 --NNMKITFCCPESWNERDPI-RALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+N F E W + + RA TCF+ L LP Y T E + E L A+ N +GF
Sbjct: 909 YGSNGPQLFTI-EQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 963
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 167 bits (423), Expect = 5e-41
Identities = 107/356 (30%), Positives = 178/356 (50%), Gaps = 15/356 (4%)
Query: 681 FDLTVRRNHLIEDVLNQLSQFENED-LRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQ 739
F++ + RN++ E+ ++ + D L+ LW+ F E G D GGV +E+F+ L EM
Sbjct: 618 FEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 677
Query: 740 PEYGMFMYPEGASCMWFPVKPKF-----EKKRYF-FFGVLCGLSLFNCNVANLPFPLALF 793
P YG+F Y + P + YF F G + GL++F+ + + F +
Sbjct: 678 PYYGLFEY-SATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFY 736
Query: 794 KKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSS 853
K +L + +L D++ + + +L+ +L+++ + +F I +L PNGS
Sbjct: 737 KMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSE 796
Query: 854 ITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNT 913
I V NKR+Y+ I + F + V+ F GF ++ D+IK+F EL+ ++ G
Sbjct: 797 IMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG 856
Query: 914 DYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDL--- 970
D D + +++ Y+ GY +HP I FWKA + E++ + L F+TGT R+ M
Sbjct: 857 DVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAEL 916
Query: 971 --NNMKITFCCPESWNERDPI-RALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+N F E W + + RA TCF+ L LP Y T E + E L A+ N +GF
Sbjct: 917 YGSNGPQLFTI-EQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 971
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 167 bits (423), Expect = 5e-41
Identities = 107/356 (30%), Positives = 178/356 (50%), Gaps = 15/356 (4%)
Query: 681 FDLTVRRNHLIEDVLNQLSQFENED-LRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQ 739
F++ + RN++ E+ ++ + D L+ LW+ F E G D GGV +E+F+ L EM
Sbjct: 497 FEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556
Query: 740 PEYGMFMYPEGASCMWFPVKPKF-----EKKRYF-FFGVLCGLSLFNCNVANLPFPLALF 793
P YG+F Y + P + YF F G + GL++F+ + + F +
Sbjct: 557 PYYGLFEY-SATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFY 615
Query: 794 KKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSS 853
K +L + +L D++ + + +L+ +L+++ + +F I +L PNGS
Sbjct: 616 KMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSE 675
Query: 854 ITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNT 913
I V NKR+Y+ I + F + V+ F GF ++ D+IK+F EL+ ++ G
Sbjct: 676 IMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG 735
Query: 914 DYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDL--- 970
D D + +++ Y+ GY +HP I FWKA + E++ + L F+TGT R+ M
Sbjct: 736 DVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAEL 795
Query: 971 --NNMKITFCCPESWNERDPI-RALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+N F E W + + RA TCF+ L LP Y T E + E L A+ N +GF
Sbjct: 796 YGSNGPQLFTI-EQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 167 bits (423), Expect = 5e-41
Identities = 107/356 (30%), Positives = 178/356 (50%), Gaps = 15/356 (4%)
Query: 681 FDLTVRRNHLIEDVLNQLSQFENED-LRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQ 739
F++ + RN++ E+ ++ + D L+ LW+ F E G D GGV +E+F+ L EM
Sbjct: 497 FEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556
Query: 740 PEYGMFMYPEGASCMWFPVKPKF-----EKKRYF-FFGVLCGLSLFNCNVANLPFPLALF 793
P YG+F Y + P + YF F G + GL++F+ + + F +
Sbjct: 557 PYYGLFEY-SATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFY 615
Query: 794 KKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSS 853
K +L + +L D++ + + +L+ +L+++ + +F I +L PNGS
Sbjct: 616 KMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSE 675
Query: 854 ITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNT 913
I V NKR+Y+ I + F + V+ F GF ++ D+IK+F EL+ ++ G
Sbjct: 676 IMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG 735
Query: 914 DYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDL--- 970
D D + +++ Y+ GY +HP I FWKA + E++ + L F+TGT R+ M
Sbjct: 736 DVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAEL 795
Query: 971 --NNMKITFCCPESWNERDPI-RALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+N F E W + + RA TCF+ L LP Y T E + E L A+ N +GF
Sbjct: 796 YGSNGPQLFTI-EQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 166 bits (420), Expect = 1e-40
Identities = 103/353 (29%), Positives = 176/353 (49%), Gaps = 11/353 (3%)
Query: 683 LTVRRNHLIEDVLNQLSQFENEDL-RKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPE 741
L +RR+HL+ED NQ+ + +DL R +L+V+F GE G D G +EFF+ + E+ P
Sbjct: 1218 LIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPY 1277
Query: 742 YGMFMYP--EGASCMWFPVKPKFEKKR--YFFFGVLCGLSLFNCNVANLPFPLALFKKLL 797
YG+F Y + + P+ + + F G + GL+L + + + F +K LL
Sbjct: 1278 YGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALL 1337
Query: 798 DQMPSLEDLKELSPDLGKNLQTLLDDE-GDNFEEVFYIHFNVHWDRNDTNLIPNGSSITV 856
+ L DL+ L + ++LQ + D++ D + F ++ V + L P G++I V
Sbjct: 1338 RILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPV 1397
Query: 857 NQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYD 916
+ NK++Y+ + + + V E RGFY++ D ++ +F EL+ VI G + D
Sbjct: 1398 TEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEID 1457
Query: 917 WKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKIT 976
+ N Y GY+ +H I FW A + E++ + L F+TGT + + +++ +
Sbjct: 1458 LSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGS 1517
Query: 977 ----FCCPESWNERDPI-RALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG 1024
C E W + + RA TCF+ L LP Y + + E L A+ FG
Sbjct: 1518 NGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFG 1570
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 164 bits (414), Expect = 5e-40
Identities = 101/356 (28%), Positives = 183/356 (51%), Gaps = 15/356 (4%)
Query: 681 FDLTVRRNHLIEDVLNQLSQFENED-LRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQ 739
F++ +RR ++ED ++ + D L+ LW+ F GE G D GGV +E+F+ + EM
Sbjct: 543 FEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 602
Query: 740 PEYGMFMYPEGASCMWFPVKPKF-----EKKRYF-FFGVLCGLSLFNCNVANLPFPLALF 793
P YG+F Y + P + YF F G + G+++++ + + F +
Sbjct: 603 PYYGLFEY-SATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFY 661
Query: 794 KKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSS 853
K +L + +L D++ + + +L+ +L+++ + F I + + L GS
Sbjct: 662 KMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSE 721
Query: 854 ITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNT 913
I V NK++Y+ I + F + ++ F+ GF+++ +D+IK+F EL+ ++ G
Sbjct: 722 IVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLG 781
Query: 914 DYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDL--- 970
D D + ++ +Y+ GY+++H I FWKA + E++ + L F+TGT R+ M
Sbjct: 782 DVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAEL 841
Query: 971 --NNMKITFCCPESWNERDPI-RALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+N +F E W + + RA TCF+ L LP Y + E + + LQ AI N +GF
Sbjct: 842 YGSNGPQSFTV-EQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 896
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 164 bits (414), Expect = 5e-40
Identities = 101/356 (28%), Positives = 183/356 (51%), Gaps = 15/356 (4%)
Query: 681 FDLTVRRNHLIEDVLNQLSQFENED-LRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQ 739
F++ +RR ++ED ++ + D L+ LW+ F GE G D GGV +E+F+ + EM
Sbjct: 890 FEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 949
Query: 740 PEYGMFMYPEGASCMWFPVKPKF-----EKKRYF-FFGVLCGLSLFNCNVANLPFPLALF 793
P YG+F Y + P + YF F G + G+++++ + + F +
Sbjct: 950 PYYGLFEY-SATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFY 1008
Query: 794 KKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSS 853
K +L + +L D++ + + +L+ +L+++ + F I + + L GS
Sbjct: 1009 KMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSE 1068
Query: 854 ITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNT 913
I V NK++Y+ I + F + ++ F+ GF+++ +D+IK+F EL+ ++ G
Sbjct: 1069 IVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLG 1128
Query: 914 DYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDL--- 970
D D + ++ +Y+ GY+++H I FWKA + E++ + L F+TGT R+ M
Sbjct: 1129 DVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAEL 1188
Query: 971 --NNMKITFCCPESWNERDPI-RALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+N +F E W + + RA TCF+ L LP Y + E + + LQ AI N +GF
Sbjct: 1189 YGSNGPQSFTV-EQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
Length = 862
Score = 155 bits (392), Expect = 2e-37
Identities = 105/363 (28%), Positives = 181/363 (49%), Gaps = 14/363 (3%)
Query: 674 EFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCL 733
+ A+ +TV R L ED Q+ F +DLR+ LWV F GE G D GGV +E+F+ L
Sbjct: 500 QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL 559
Query: 734 FAEMIQPEYGMFMYPEGASCMWFPVKPKF----EKKRYF-FFGVLCGLSLFNCNVANLPF 788
E++ P Y +F Y G + P + +YF F G ++LF+ + F
Sbjct: 560 SHEVLNPMYCLFEY-AGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGF 618
Query: 789 PLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDD--EGDNFEEVFYIHFNVHWDRNDTN 846
L +K++L++ L+DL+ + P+ +L + ++ E + E F + + + +
Sbjct: 619 SLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHD 678
Query: 847 LIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELK 906
L PNG +I V + NK +Y+ + + V+ + F GF ++ + ++ F +EL+
Sbjct: 679 LKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELE 738
Query: 907 DVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQ 966
++ G + D ++++A Y Y + I+ FW+ ++ E++ + L F+TGT RL
Sbjct: 739 VLLCGMQEIDLNDWQRHAIYR-HYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLP 797
Query: 967 M---KDL--NNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNR 1021
+ DL +N FC + E R+ TCF+ L LP Y + E ++E L AI
Sbjct: 798 VGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETE 857
Query: 1022 GFG 1024
GFG
Sbjct: 858 GFG 860
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 155 bits (392), Expect = 2e-37
Identities = 101/353 (28%), Positives = 170/353 (48%), Gaps = 11/353 (3%)
Query: 683 LTVRRNHLIEDVLNQLSQFENEDL-RKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPE 741
L +RR+HL+E NQ+ + ++L R +L+V+F GE G D G +EFF+ L E+ P
Sbjct: 1252 LIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPY 1311
Query: 742 YGMFMYP--EGASCMWFPVKPKFEK--KRYFFFGVLCGLSLFNCNVANLPFPLALFKKLL 797
YG+F Y + + P+ E + + F G + GL+L + + + F +K LL
Sbjct: 1312 YGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALL 1371
Query: 798 DQMPSLEDLKELSPDLGKNLQTLLDDE-GDNFEEVFYIHFNVHWDRNDTNLIPNGSSITV 856
L DL+ L + ++LQ + D+ D + F ++ V + L G++ V
Sbjct: 1372 RLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQV 1431
Query: 857 NQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYD 916
+ NK++Y+ + + + V E RGFY++ D ++ +F EL+ VI G + D
Sbjct: 1432 TEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEID 1491
Query: 917 WKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMK-- 974
+ N Y GY+ H I FW A + E++ + L F+TGT + + ++
Sbjct: 1492 LNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGS 1551
Query: 975 --ITFCCPESWNERDPI-RALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG 1024
+ C E W + + RA TCF+ L LP Y + + E L A+ FG
Sbjct: 1552 NGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFG 1604
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 151 bits (381), Expect = 3e-36
Identities = 101/354 (28%), Positives = 177/354 (50%), Gaps = 16/354 (4%)
Query: 683 LTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEY 742
+ V R + E+ Q+ + +DL K L + F GE G D GGV +E+ Y L EM+ P Y
Sbjct: 395 IEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYY 454
Query: 743 GMFMYPEGASCMWFPVKPKF----EKKRYFFF-GVLCGLSLFNCNVANLPFPLALFKKLL 797
G+F Y + P E YF F G + G+++F+ + + F L +K+LL
Sbjct: 455 GLFQYSRD-DIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLL 513
Query: 798 DQMPSLEDLKELSPDLGKNLQTLLDDEGDN-FEEVFYIHFNVHWDRNDTNLIPNGSSITV 856
+ +L+D++ + PDL +L +L+++ + F + N + + L PNG SI V
Sbjct: 514 GKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPV 573
Query: 857 NQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYD 916
N+ NK++YV Y+N+ F ++A + ++GF ++ + ++K F +EL+ +I G D
Sbjct: 574 NEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKID 633
Query: 917 WKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMK-- 974
++ N R + S+ + FWKA E + + L F+TG+ R+ ++ ++
Sbjct: 634 VNDWKVNTRLKHCTPDSN-IVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGA 692
Query: 975 -----ITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
T ++ P +A TCF+ + +P Y + E + E L AI GF
Sbjct: 693 AGPRLFTIHQIDACTNNLP-KAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 147 bits (371), Expect = 5e-35
Identities = 100/357 (28%), Positives = 175/357 (49%), Gaps = 19/357 (5%)
Query: 683 LTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEY 742
+ V R + E+ Q+ + +DL+K L V F GE G D GGV +E+ Y L EM+ P Y
Sbjct: 401 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYY 460
Query: 743 GMFMYPEGASCMWFPVKPKF----EKKRYF-FFGVLCGLSLFNCNVANLPFPLALFKKLL 797
G+F Y M + P + YF F G + GL++F+ + N F + +K+LL
Sbjct: 461 GLFQYSTDNIYM-LQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLL 519
Query: 798 DQMPSLEDLKELSPDLGKNLQTLLD-DEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITV 856
+ L DL+ + P+L K+L +L+ D + F + N L PNG ++ V
Sbjct: 520 GKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPV 579
Query: 857 NQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYD 916
+ NK++YV Y+N+ F ++A + ++GF ++ + ++K F +EL+ +I G D
Sbjct: 580 TEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKID 639
Query: 917 WKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMK-- 974
++ N R + S+ + FW+A E + + L F+TG+ R+ ++ ++
Sbjct: 640 LNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGS 698
Query: 975 --------ITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
T ++ + P +A TCF+ + +P Y + E + E L A+ GF
Sbjct: 699 TGAAGPRLFTIHLIDANTDNLP-KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 754
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 147 bits (371), Expect = 5e-35
Identities = 100/357 (28%), Positives = 175/357 (49%), Gaps = 19/357 (5%)
Query: 683 LTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEY 742
+ V R + E+ Q+ + +DL+K L V F GE G D GGV +E+ Y L EM+ P Y
Sbjct: 375 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYY 434
Query: 743 GMFMYPEGASCMWFPVKPKF----EKKRYF-FFGVLCGLSLFNCNVANLPFPLALFKKLL 797
G+F Y M + P + YF F G + GL++F+ + N F + +K+LL
Sbjct: 435 GLFQYSTDNIYM-LQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLL 493
Query: 798 DQMPSLEDLKELSPDLGKNLQTLLD-DEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITV 856
+ L DL+ + P+L K+L +L+ D + F + N L PNG ++ V
Sbjct: 494 GKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPV 553
Query: 857 NQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYD 916
+ NK++YV Y+N+ F ++A + ++GF ++ + ++K F +EL+ +I G D
Sbjct: 554 TEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKID 613
Query: 917 WKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMK-- 974
++ N R + S+ + FW+A E + + L F+TG+ R+ ++ ++
Sbjct: 614 LNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGS 672
Query: 975 --------ITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
T ++ + P +A TCF+ + +P Y + E + E L A+ GF
Sbjct: 673 TGAAGPRLFTIHLIDANTDNLP-KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 144 bits (363), Expect = 4e-34
Identities = 91/262 (34%), Positives = 141/262 (53%), Gaps = 18/262 (6%)
Query: 95 KNMKIHSVDQGAEHMLILSSDGKPFEY---DNYSMKHL--------RFESILQEKKIIQI 143
K + +HS G H L+ DGK F + D+ + H R L+ K+I I
Sbjct: 3048 KKVAVHS---GGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDI 3104
Query: 144 TCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAG--EA 201
CG HS AL+ GEL+ WG +G+LG G + P++V+ L G + Q++ G +A
Sbjct: 3105 ACGSSHSAALTSSGELYTWGLGEYGRLGHGDN-TTQLKPKMVKVLLGHRVIQVACGSRDA 3163
Query: 202 HSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQD 261
++AL+ G ++SWG + G+LG G +E + P IE L+ Q V + CG S LT+
Sbjct: 3164 QTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKS 3223
Query: 262 GLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFG 321
G+++T+G G + +LGH S + +P +V L G ++ +A G H LA V+D G+V+++G
Sbjct: 3224 GVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLA-VTDSGQVYAWG 3282
Query: 322 SGKDGQLGNGGTRDQLMPLPVK 343
GQ GNG T P V+
Sbjct: 3283 DNDHGQQGNGTTTVNRKPTLVQ 3304
Score = 142 bits (358), Expect = 2e-33
Identities = 76/213 (35%), Positives = 127/213 (59%), Gaps = 5/213 (2%)
Query: 131 FESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAG 190
F L ++Q+ G A++ G+++A G+ +G+LG+G + P+ + L+
Sbjct: 2985 FSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSS 3044
Query: 191 VPLAQIS--AGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFV 248
+ +++ +G H+ AL++ G ++SWG+ + G+LG + D P LIE L +++ +
Sbjct: 3045 YVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDI 3104
Query: 249 ACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGR--WH 306
ACG SHSA LT G L+T+G G++G+LGH +L+P +V L+G+RV Q+ACG
Sbjct: 3105 ACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQ 3164
Query: 307 TLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMP 339
TLA ++D G VFS+G G G+LG GG+ +P
Sbjct: 3165 TLA-LTDEGLVFSWGDGDFGKLGRGGSEGCNIP 3196
Score = 138 bits (348), Expect = 2e-32
Identities = 79/206 (38%), Positives = 125/206 (60%), Gaps = 6/206 (2%)
Query: 141 IQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQIS--A 198
+Q+ G+ A++ G+L+A G G+LG+G S +TP ++E + V + +++ +
Sbjct: 3988 VQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGT-ESVSTPTLLESIQHVFIKKVAVNS 4046
Query: 199 GEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALL 258
G H +ALS G +YSWG+ E G+LG G+ D P +IE L +V VA GG+HSA +
Sbjct: 4047 GGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACV 4106
Query: 259 TQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRW--HTLAYVSDLGK 316
T G L+T+G G++G+LGH+ ++++L+P LV L G+RV IACG TL D
Sbjct: 4107 TAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDD-DT 4165
Query: 317 VFSFGSGKDGQLGNGGTRDQLMPLPV 342
V+S+G G G+LG GG+ +P+ +
Sbjct: 4166 VWSWGDGDYGKLGRGGSDGCKVPMKI 4191
Score = 130 bits (328), Expect = 5e-30
Identities = 75/238 (31%), Positives = 123/238 (51%), Gaps = 14/238 (5%)
Query: 88 PKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEY-----------DNYSMKHLRFESILQ 136
P+ I+ K +I + G+ H L+S G+ + + DN + + +L
Sbjct: 3090 PRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLL 3149
Query: 137 EKKIIQITCG--DYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194
++IQ+ CG D +LAL+ G +F+WG G+LG G PQ +E L G +
Sbjct: 3150 GHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGS-EGCNIPQNIERLNGQGVC 3208
Query: 195 QISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSH 254
QI G S+AL+ SG +++WGK + +LG G P ++EGL +K+ VA G H
Sbjct: 3209 QIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALH 3268
Query: 255 SALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVS 312
+T G ++ +G HGQ G+ +T +P LV L G ++T++ACG H++A+ +
Sbjct: 3269 CLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3326
Score = 125 bits (313), Expect = 3e-28
Identities = 85/311 (27%), Positives = 151/311 (48%), Gaps = 28/311 (9%)
Query: 79 LAGSGGARTPKCIKLGKNMKIH--SVDQGAEHMLILSSDGKPFEYDNYSMKHL------- 129
+ G+ TP ++ +++ I +V+ G +H L LSS+G+ + + L
Sbjct: 4019 IGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSP 4078
Query: 130 ----RFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIV 185
R L+ +++ + G HS ++ G+L+ WG+ +G+LG P++V
Sbjct: 4079 CDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS-EDQLKPKLV 4137
Query: 186 EHLAGVPLAQIS--AGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQ 243
E L G + I+ +G+A ++ L+ ++SWG + G+LG G ++ P I+ L
Sbjct: 4138 EALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGL 4197
Query: 244 KVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACG 303
V V CG S LT+ G ++T+G G + +LGH S + RP V L G +V IA G
Sbjct: 4198 GVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATG 4257
Query: 304 RWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIM 363
H + D G+V+++G +GQLG+G T ++ + +L + K++
Sbjct: 4258 SLHCVCCTED-GEVYTWGDNDEGQLGDGTT-----------NAIQRPRLVAALQGKKVNR 4305
Query: 364 IAGGNQSILLW 374
+A G+ L W
Sbjct: 4306 VACGSAHTLAW 4316
Score = 124 bits (311), Expect = 5e-28
Identities = 73/202 (36%), Positives = 115/202 (56%), Gaps = 20/202 (9%)
Query: 140 IIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAG 199
+ QI C + L LS+ G ++ N T PQ+V+ LA + +I+A
Sbjct: 453 VTQIACAEKRFLILSRNGRVYTQAYN-----------SDTLAPQLVQGLASRNIVKIAAH 501
Query: 200 EA--HSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQK----VEFVACGGS 253
H +AL+ +G +YSWG + G+LG G T ++P +I ++ V +ACG +
Sbjct: 502 SDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGST 561
Query: 254 HSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRW--HTLAYV 311
+SA +T +G L+T+G G +G+LGH S+++E P LVA L G +V +ACG TLA V
Sbjct: 562 YSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLA-V 620
Query: 312 SDLGKVFSFGSGKDGQLGNGGT 333
++ G+V+S+G G G+LG GG+
Sbjct: 621 TENGQVWSWGDGDYGKLGRGGS 642
Score = 120 bits (301), Expect = 7e-27
Identities = 81/292 (27%), Positives = 145/292 (49%), Gaps = 25/292 (8%)
Query: 55 QLCCSPGRLAVLERGGAGVQVHQLLAGSGGARTPKCIK--LGKNMKIHSVDQGAEHMLIL 112
Q+ C+ R +L R G +V+ A + P+ ++ +N+ + H L L
Sbjct: 455 QIACAEKRFLILSRNG---RVYTQ-AYNSDTLAPQLVQGLASRNIVKIAAHSDGHHYLAL 510
Query: 113 SSDGKPFEY-----------DNYSMKHLRFESILQEKK----IIQITCGDYHSLALSKGG 157
++ G+ + + D ++ + S K+ ++ I CG +S A++ G
Sbjct: 511 AATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEG 570
Query: 158 ELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQIS--AGEAHSMALSMSGNIYSW 215
EL+ WG+ +G+LG G P +V L G+ + ++ +G+A ++A++ +G ++SW
Sbjct: 571 ELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSW 629
Query: 216 GKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQL 275
G + G+LG G ++ P LIE L + V V CG S LT+DG ++++G G + +L
Sbjct: 630 GDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRL 689
Query: 276 GHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQ 327
GH + ++ P L+ L G +V +A G H LA D +V S+GS Q
Sbjct: 690 GHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTED-SEVHSWGSNDQCQ 740
Score = 114 bits (286), Expect = 4e-25
Identities = 74/246 (30%), Positives = 130/246 (52%), Gaps = 13/246 (5%)
Query: 96 NMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFESI--LQEKKIIQITCGD--YHSL 151
N+ + + + LILS +G+ + Y+ L + + L + I++I +H L
Sbjct: 450 NLGVTQIACAEKRFLILSRNGRVYT-QAYNSDTLAPQLVQGLASRNIVKIAAHSDGHHYL 508
Query: 152 ALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHL----AGVPLAQISAGEAHSMALS 207
AL+ GE+++WG G+LG G P P+++ AG + I+ G +S A++
Sbjct: 509 ALAATGEVYSWGCGDGGRLGHGDTVP-LEEPKVISAFSGKQAGKHVVHIACGSTYSAAIT 567
Query: 208 MSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALL--TQDGLLF 265
G +Y+WG+ G+LG G +E + P L+ GL KV VACG + L T++G ++
Sbjct: 568 AEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVW 627
Query: 266 TFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKD 325
++G G +G+LG + P L+ +L V ++ CG ++A D G+V+S+G G +
Sbjct: 628 SWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKD-GQVYSWGKGDN 686
Query: 326 GQLGNG 331
+LG+G
Sbjct: 687 QRLGHG 692
Score = 108 bits (270), Expect = 3e-23
Identities = 69/190 (36%), Positives = 104/190 (54%), Gaps = 5/190 (2%)
Query: 158 ELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGK 217
++F WG N QLG G K P E L+ + + Q++ G A+++ G +Y+ G+
Sbjct: 2960 KVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGE 3018
Query: 218 NECGQLGLG-HTESKDDPSLIEGLDNQKVEFVA--CGGSHSALLTQDGLLFTFGAGKHGQ 274
G+LGLG + + P I L + V+ VA GG H+ LT DG +F++G G G+
Sbjct: 3019 ATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGK 3078
Query: 275 LGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTR 334
LGH S N +P L+ L R+ IACG H+ A S G+++++G G+ G+LG+G
Sbjct: 3079 LGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSS-GELYTWGLGEYGRLGHGDNT 3137
Query: 335 DQLMPLPVKV 344
QL P VKV
Sbjct: 3138 TQLKPKMVKV 3147
Score = 108 bits (270), Expect = 3e-23
Identities = 64/195 (32%), Positives = 105/195 (53%), Gaps = 4/195 (2%)
Query: 147 DYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMAL 206
D +L+ G ++ WG N GQLG G + P E LA + Q+ GE A+
Sbjct: 3942 DDWTLSAGGSGTIYGWGHNHRGQLG-GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAV 4000
Query: 207 SMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVA--CGGSHSALLTQDGLL 264
+ G +Y+ G G+LG+G TES P+L+E + + ++ VA GG H L+ +G +
Sbjct: 4001 TADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEV 4060
Query: 265 FTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGK 324
+++G + G+LGH + RP ++ L G V +A G H+ A V+ G ++++G G+
Sbjct: 4061 YSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHS-ACVTAAGDLYTWGKGR 4119
Query: 325 DGQLGNGGTRDQLMP 339
G+LG+ + DQL P
Sbjct: 4120 YGRLGHSDSEDQLKP 4134
Score = 99.4 bits (246), Expect = 2e-20
Identities = 57/180 (31%), Positives = 95/180 (52%), Gaps = 3/180 (1%)
Query: 135 LQEKKIIQITCG--DYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVP 192
L+ K+I + CG D +LA+++ G++++WG +G+LG G TP+++E L +
Sbjct: 600 LKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLIEKLQDLD 658
Query: 193 LAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGG 252
+ ++ G S+AL+ G +YSWGK + +LG G E P L+EGL +KV VA G
Sbjct: 659 VVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGS 718
Query: 253 SHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVS 312
+H LT+D + ++G+ Q + P + L + IACG + A+ S
Sbjct: 719 THCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSS 778
Score = 78.6 bits (192), Expect = 3e-14
Identities = 71/259 (27%), Positives = 117/259 (45%), Gaps = 16/259 (6%)
Query: 769 FFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNF 828
F GVL G+++ + +L ++K+L ++ DL E+ D L + D+E +
Sbjct: 4535 FLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSE 4594
Query: 829 E-EVFYIHFNV-HWDRNDTNLIPNGSSITVNQTNKRDYVSKYINYI---FNDSVKAVYEE 883
E E + F V D L + IT++ N+ +YV INY F++ V AV
Sbjct: 4595 EFEAMSLPFTVPSASGQDIQLSSKHTHITLD--NRAEYVRLAINYRLHEFDEQVAAV--- 4649
Query: 884 FRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKA 943
R G ++ ++ LF EL+ ++ G+ D + A Y+ G S I FW+
Sbjct: 4650 -REGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYK-GIEPSASLIQWFWEV 4707
Query: 944 FHKLTLEEKKKFLVFLTGTDRLQ--MKDLNNMKITFCCPESWNERDPI--RALTCFSVLF 999
+ E+ FL F+ G RL + D + +N D + TCF +L
Sbjct: 4708 MESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLK 4767
Query: 1000 LPKYSTMETVEEALQEAIN 1018
LP+YS + +EE L+ AI+
Sbjct: 4768 LPRYSCKQVLEEKLKYAIH 4786
Score = 70.9 bits (172), Expect = 6e-12
Identities = 51/192 (26%), Positives = 91/192 (47%), Gaps = 25/192 (13%)
Query: 158 ELFAWGQNLHGQLGVGRKFPSTTTPQI-VEHLAGVPLAQISAGEAHSMALSMSGNIYSWG 216
E+ WG +G K+ + I E LA + + QI+ E + LS +G +Y+
Sbjct: 424 EVIGWGL-------IGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQA 476
Query: 217 KNECGQLGLGHTESKDDPSLIEGLDNQKVEFVAC--GGSHSALLTQDGLLFTFGAGKHGQ 274
N P L++GL ++ + +A G H L G ++++G G G+
Sbjct: 477 YNS----------DTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGR 526
Query: 275 LGHNSTQNELRPCLVAEL----VGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGN 330
LGH T P +++ G V IACG ++ A ++ G+++++G G G+LG+
Sbjct: 527 LGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAE-GELYTWGRGNYGRLGH 585
Query: 331 GGTRDQLMPLPV 342
G + D+ +P+ V
Sbjct: 586 GSSEDEAIPMLV 597
Score = 33.1 bits (74), Expect = 1.4
Identities = 24/91 (26%), Positives = 46/91 (50%), Gaps = 12/91 (13%)
Query: 76 HQLLAGSGG-ARTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEY-DN---------- 123
H+L GS R P+ ++ + K+ ++ G+ H + + DG+ + + DN
Sbjct: 4227 HRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTT 4286
Query: 124 YSMKHLRFESILQEKKIIQITCGDYHSLALS 154
+++ R + LQ KK+ ++ CG H+LA S
Sbjct: 4287 NAIQRPRLVAALQGKKVNRVACGSAHTLAWS 4317
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 139 bits (350), Expect = 1e-32
Identities = 75/206 (36%), Positives = 116/206 (56%), Gaps = 4/206 (1%)
Query: 142 QITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQI---SA 198
Q+ CG + + G + A G+ +G+LG G ++ L G + Q+
Sbjct: 4031 QVICGQNCTFVIQANGTVLACGEGSYGRLGQGNS-DDLHVLTVISALQGFVVTQLVTSCG 4089
Query: 199 GEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALL 258
+ HSMAL+ SG ++SWG + G+LG G+++ + P IE L ++V ++CG HSA++
Sbjct: 4090 SDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVV 4149
Query: 259 TQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVF 318
T DG LFTFG G +G+LG +T N+ P V L GY++ Q+ACG HTLA +D V+
Sbjct: 4150 TSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVW 4209
Query: 319 SFGSGKDGQLGNGGTRDQLMPLPVKV 344
+FG G G+LG G + + P + V
Sbjct: 4210 AFGDGDYGKLGLGNSTAKSSPQKIDV 4235
Score = 125 bits (313), Expect = 3e-28
Identities = 70/200 (35%), Positives = 117/200 (58%), Gaps = 3/200 (1%)
Query: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194
LQ ++++Q++CG HS ++ G+LF +G +G+LG+G + P+ V L G +
Sbjct: 4131 LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNT-SNKKLPERVTALEGYQIG 4189
Query: 195 QISAGEAHSMALSMSGN-IYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGS 253
Q++ G H++A+S G+ ++++G + G+LGLG++ +K P I+ L ++ VACG
Sbjct: 4190 QVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQ 4249
Query: 254 HSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSD 313
S LT+DG ++TFG + L +N RP + L G + +A G HTLA S+
Sbjct: 4250 FSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASN 4309
Query: 314 LGKVFSFGSGKDGQLGNGGT 333
G V+++GS +GQLG G T
Sbjct: 4310 -GDVYAWGSNSEGQLGLGHT 4328
Score = 124 bits (312), Expect = 3e-28
Identities = 92/341 (26%), Positives = 161/341 (47%), Gaps = 33/341 (9%)
Query: 10 RRNGRSTAGKAAATQPAKSPGAQLWLFPSAAGLHRALLRRVEVTRQLCCSPGRLAVLERG 69
RR+ S+A ++ +P ++ L+ +A L + R + C SP + + G
Sbjct: 307 RRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI---QTG 363
Query: 70 GAGVQVHQLLAGSGGARTPKCIKLGKNMKI------------HSVDQGAEHMLILSSDGK 117
A + G+ + + G KI +++ G ++S+DG
Sbjct: 364 DAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGS 423
Query: 118 PF-------------EYDNYS-MKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWG 163
+ +N S +K L FE KK+ D H+LA + GE+F+WG
Sbjct: 424 VRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWG 483
Query: 164 QNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQL 223
+G+LG G I L G + +SAG HS A++ G +Y+WG+ + G+L
Sbjct: 484 DGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRL 543
Query: 224 GLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDG-LLFTFGAGKHGQLGHNSTQN 282
G G + S++ P+L++ + N V V+CG SH+ L++DG +++FG G +G+LGH T
Sbjct: 544 GHGDSNSRNIPTLVKDISN--VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNR 601
Query: 283 ELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSG 323
+P ++ L G + ++ G +LA S G+V+++G G
Sbjct: 602 VYKPKVIEALQGMFIRKVCAGSQSSLALTS-TGQVYAWGCG 641
Score = 120 bits (301), Expect = 7e-27
Identities = 69/228 (30%), Positives = 121/228 (53%), Gaps = 5/228 (2%)
Query: 143 ITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIV--EHLAGVPLAQISAGE 200
I G Y + +S G + A G+ +G+LG+G +T ++ H + ++ +
Sbjct: 408 IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSD 467
Query: 201 AHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEG-LDNQKVEFVACGGSHSALLT 259
H++A + G ++SWG + G+LG G++ ++ P LI+G L + V V+ G HSA +T
Sbjct: 468 GHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVT 527
Query: 260 QDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFS 319
+DG L+T+G G G+LGH + + P LV ++ V +++CG HT+A D V+S
Sbjct: 528 EDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN--VGEVSCGSSHTIALSKDGRTVWS 585
Query: 320 FGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGG 367
FG G +G+LG+G T P ++ ++ S+ L + + G
Sbjct: 586 FGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTG 633
Score = 110 bits (276), Expect = 5e-24
Identities = 69/239 (28%), Positives = 124/239 (51%), Gaps = 13/239 (5%)
Query: 86 RTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFESILQEK------- 138
R P+ I+ + ++ + G +H +++SDGK F + N L + +K
Sbjct: 4123 RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTA 4182
Query: 139 ----KIIQITCGDYHSLALSKGGEL-FAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPL 193
+I Q+ CG H+LA+S G + +A+G +G+LG+G + ++PQ ++ L G+ +
Sbjct: 4183 LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNS-TAKSSPQKIDVLCGIGI 4241
Query: 194 AQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGS 253
+++ G S+AL+ G++Y++G++ L G + + P I L +E VA G
Sbjct: 4242 KKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAE 4301
Query: 254 HSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVS 312
H+ L +G ++ +G+ GQLG T + P LV L G V QI+ GR H+ A+ +
Sbjct: 4302 HTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTA 4360
Score = 95.5 bits (236), Expect = 2e-19
Identities = 58/193 (30%), Positives = 99/193 (51%), Gaps = 13/193 (6%)
Query: 79 LAGSGGARTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPF------EYDNYSMKHLRFE 132
L + + P+ + + +I V G H L +S+DG +Y + + +
Sbjct: 4168 LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 4227
Query: 133 SILQEKKII------QITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVE 186
S Q+ ++ ++ CG S+AL+K G ++ +GQ+ L GR + PQ +
Sbjct: 4228 SSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNRPQQIP 4286
Query: 187 HLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVE 246
LAGV + ++ G H++AL+ +G++Y+WG N GQLGLGHT +P+L+ GL + V
Sbjct: 4287 VLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVR 4346
Query: 247 FVACGGSHSALLT 259
++ G HSA T
Sbjct: 4347 QISAGRCHSAAWT 4359
Score = 94.4 bits (233), Expect = 5e-19
Identities = 71/248 (28%), Positives = 124/248 (50%), Gaps = 19/248 (7%)
Query: 81 GSGGARTPKCIKLGKN----MKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHL------- 129
G G + T K KL + + V G H ++ DG+ + + L
Sbjct: 491 GHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNS 550
Query: 130 -RFESILQE-KKIIQITCGDYHSLALSKGGE-LFAWGQNLHGQLGVGRKFPSTTTPQIVE 186
+++++ + +++CG H++ALSK G ++++G +G+LG G P+++E
Sbjct: 551 RNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDT-NRVYKPKVIE 609
Query: 187 HLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKD-DPSLIEGLDNQKV 245
L G+ + ++ AG S+AL+ +G +Y+WG C LG G +E+ P LIE L ++
Sbjct: 610 ALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRI 667
Query: 246 EFVACGGSHSALLTQDGLLFTFGAGKHGQLGH-NSTQNELRPCLVAELVGYRVTQIACGR 304
V+ G SH L+ D ++ +G GQ G NST +P V+ L G + QI+ G
Sbjct: 668 VDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGT 727
Query: 305 WHTLAYVS 312
H+LA+ +
Sbjct: 728 SHSLAWTA 735
Score = 77.8 bits (190), Expect = 5e-14
Identities = 61/238 (25%), Positives = 115/238 (48%), Gaps = 16/238 (6%)
Query: 131 FESILQEKKIIQITCGDYHSLA------LSKGGELFAWGQNLHGQLGVGRKFPSTTTPQI 184
FE + + TC S+ +S+ E++ WG N QL G + P++
Sbjct: 340 FEEVCRMASDYSRTCASPDSIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQ-EKILQPKL 398
Query: 185 VEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQK 244
+ I AG+ + +S G++ + GK G+LGLG + ++ + ++
Sbjct: 399 APSFSDAQT--IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRS 456
Query: 245 VEFVACG---GSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLV-AELVGYRVTQI 300
++ V+ H+ T +G +F++G G +G+LGH ++ + P L+ L G V +
Sbjct: 457 IKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCV 516
Query: 301 ACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVK-VSSSEELKL-ESHT 356
+ G H+ A D G+++++G G G+LG+G + + +P VK +S+ E+ SHT
Sbjct: 517 SAGYRHSAAVTED-GELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHT 573
Score = 75.5 bits (184), Expect = 2e-13
Identities = 66/264 (25%), Positives = 125/264 (47%), Gaps = 11/264 (4%)
Query: 766 RYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLL--DD 823
++ F G+L G+++ +L ++K+L +LEDL+E+ + L ++L +D
Sbjct: 4578 QFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIED 4637
Query: 824 EG---DNFEEVFYIHFNVHW--DRNDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVK 878
G ++F E+ + V D +IP G+SI + +N+++YV + I Y ++ +
Sbjct: 4638 SGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDR 4697
Query: 879 AVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIV 938
V R G + ++ L ++L+ ++ G + + +K RY + H +
Sbjct: 4698 QV-AAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQ 4755
Query: 939 MFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNERDPI-RALTCFSV 997
FW + + EE+ F+ F++G RL + + F + D + + TCF
Sbjct: 4756 WFWHTLEEFSNEERVLFMRFVSGRSRLPANTAD-ISQRFQIMKVDRPYDSLPTSQTCFFQ 4814
Query: 998 LFLPKYSTMETVEEALQEAINNNR 1021
L LP YS+ + E L+ AINN R
Sbjct: 4815 LRLPPYSSQLVMAERLRYAINNCR 4838
Score = 71.6 bits (174), Expect = 3e-12
Identities = 49/149 (32%), Positives = 73/149 (48%), Gaps = 13/149 (8%)
Query: 88 PKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYD--------NYSMKHLRFESI--LQE 137
PK I+ + M I V G++ L L+S G+ + + + LR + I L
Sbjct: 605 PKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAA 664
Query: 138 KKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQIS 197
+I+ ++ GD H LALS E++AWG N GQ G G T P+ V L G+ + QIS
Sbjct: 665 TRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQIS 724
Query: 198 AGEAHSM---ALSMSGNIYSWGKNECGQL 223
AG +HS+ AL + +W + C L
Sbjct: 725 AGTSHSLAWTALPRDRQVVAWHRPYCVDL 753
Score = 58.2 bits (139), Expect = 4e-08
Identities = 41/146 (28%), Positives = 75/146 (51%), Gaps = 13/146 (8%)
Query: 211 NIYSWGKNECGQL---GLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTF 267
++Y WG GQL G PS + + V CG + + ++ +G +
Sbjct: 3998 DVYLWGAGRHGQLAEAGRNVMVPAAAPSF------SQAQQVICGQNCTFVIQANGTVLAC 4051
Query: 268 GAGKHGQLGHNSTQNELRPCLVAELVGYRVTQI--ACGR-WHTLAYVSDLGKVFSFGSGK 324
G G +G+LG ++ + +++ L G+ VTQ+ +CG H++A +++ G+VFS+G G
Sbjct: 4052 GEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMA-LTESGEVFSWGDGD 4110
Query: 325 DGQLGNGGTRDQLMPLPVKVSSSEEL 350
G+LG+G + Q P ++ EE+
Sbjct: 4111 YGKLGHGNSDRQRRPRQIEALQGEEV 4136
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 137 bits (344), Expect = 7e-32
Identities = 97/361 (26%), Positives = 170/361 (47%), Gaps = 14/361 (3%)
Query: 676 ALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFA 735
AL ++V R L ED Q+ + DLR+ L++ GE G D GG+ +E+F+ L
Sbjct: 71 ALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSH 130
Query: 736 EMIQPEYGMFMYPEGASCMWFPVKPKF----EKKRYF-FFGVLCGLSLFNCNVANLPFPL 790
E++ P Y +F Y G + + P + YF F G ++L++ + F L
Sbjct: 131 EVLNPMYCLFEY-AGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTL 189
Query: 791 ALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDD--EGDNFEEVFYIHFNVHWDRNDTNLI 848
+K++L++ P+L+DL+ + P+ ++ + ++ E E F + L
Sbjct: 190 PFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELK 249
Query: 849 PNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDV 908
G SI V + NK +Y+ ++ F V+ + F GF ++ + ++ F +EL+ +
Sbjct: 250 EGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELM 309
Query: 909 IVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMK 968
+ G + D ++K+ Y Y + I FW+ ++ E++ + L F+TGT RL +
Sbjct: 310 LCGMQEIDMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVG 368
Query: 969 DL-----NNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+N FC + E R+ TCF+ L LP Y + E + E L AI GF
Sbjct: 369 GFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 428
Query: 1024 G 1024
G
Sbjct: 429 G 429
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 137 bits (344), Expect = 7e-32
Identities = 97/361 (26%), Positives = 170/361 (47%), Gaps = 14/361 (3%)
Query: 676 ALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFA 735
AL ++V R L ED Q+ + DLR+ L++ GE G D GG+ +E+F+ L
Sbjct: 510 ALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSH 569
Query: 736 EMIQPEYGMFMYPEGASCMWFPVKPKF----EKKRYF-FFGVLCGLSLFNCNVANLPFPL 790
E++ P Y +F Y G + + P + YF F G ++L++ + F L
Sbjct: 570 EVLNPMYCLFEY-AGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTL 628
Query: 791 ALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDD--EGDNFEEVFYIHFNVHWDRNDTNLI 848
+K++L++ P+L+DL+ + P+ ++ + ++ E E F + L
Sbjct: 629 PFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELK 688
Query: 849 PNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDV 908
G SI V + NK +Y+ ++ F V+ + F GF ++ + ++ F +EL+ +
Sbjct: 689 EGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELM 748
Query: 909 IVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMK 968
+ G + D ++K+ Y Y + I FW+ ++ E++ + L F+TGT RL +
Sbjct: 749 LCGMQEIDMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVG 807
Query: 969 DL-----NNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
+N FC + E R+ TCF+ L LP Y + E + E L AI GF
Sbjct: 808 GFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 867
Query: 1024 G 1024
G
Sbjct: 868 G 868
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,948,035
Number of Sequences: 37866
Number of extensions: 1836883
Number of successful extensions: 5150
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 4260
Number of HSP's gapped (non-prelim): 241
length of query: 1024
length of database: 18,247,518
effective HSP length: 112
effective length of query: 912
effective length of database: 14,006,526
effective search space: 12773951712
effective search space used: 12773951712
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.