Search of human proteins with 168229161

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|168229161 coronin 7 [Homo sapiens]
         (925 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|168229161 coronin 7 [Homo sapiens]                                1875   0.0  
gi|5902134 coronin, actin binding protein, 1A [Homo sapiens]          240   4e-63
gi|65787364 coronin, actin binding protein, 1B [Homo sapiens]         235   2e-61
gi|14149734 coronin, actin binding protein, 1B [Homo sapiens]         235   2e-61
gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo sa...   233   5e-61
gi|109627650 coronin 6 [Homo sapiens]                                 219   9e-57
gi|209529711 coronin, actin binding protein, 2A [Homo sapiens]        210   4e-54
gi|16554585 coronin, actin binding protein, 2A [Homo sapiens]         210   4e-54
gi|148529011 coronin, actin binding protein, 2B [Homo sapiens]        209   7e-54
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            73   1e-12
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     69   3e-11
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     65   3e-10
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     65   3e-10
gi|15150805 transducin beta-like 1Y [Homo sapiens]                     65   3e-10
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     64   5e-10
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa...    64   6e-10
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa...    64   6e-10
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi...    64   6e-10
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          64   6e-10
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          64   6e-10
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          64   6e-10
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            64   6e-10
gi|62234438 Notchless gene homolog isoform b [Homo sapiens]            64   6e-10
gi|4757988 WD repeat domain 39 [Homo sapiens]                          64   8e-10
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]             64   8e-10
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...    63   1e-09
gi|26665869 WD repeat domain 51B [Homo sapiens]                        63   1e-09
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             62   2e-09
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             62   2e-09
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             62   2e-09

>gi|168229161 coronin 7 [Homo sapiens]
          Length = 925

 Score = 1875 bits (4857), Expect = 0.0
 Identities = 925/925 (100%), Positives = 925/925 (100%)

Query: 1   MNRFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPGVLGIVPL 60
           MNRFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPGVLGIVPL
Sbjct: 1   MNRFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPGVLGIVPL 60

Query: 61  QGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGV 120
           QGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGV
Sbjct: 61  QGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGV 120

Query: 121 VLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDG 180
           VLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDG
Sbjct: 121 VLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDG 180

Query: 181 ALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREV 240
           ALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREV
Sbjct: 181 ALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREV 240

Query: 241 KLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPV 300
           KLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPV
Sbjct: 241 KLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPV 300

Query: 301 TQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFPDT 360
           TQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFPDT
Sbjct: 301 TQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFPDT 360

Query: 361 AGCVPATDPHSWWAGDNQQVQKVSLNPACRPHPSFTSCLVPPAEPLPDTAQPAVMETPVG 420
           AGCVPATDPHSWWAGDNQQVQKVSLNPACRPHPSFTSCLVPPAEPLPDTAQPAVMETPVG
Sbjct: 361 AGCVPATDPHSWWAGDNQQVQKVSLNPACRPHPSFTSCLVPPAEPLPDTAQPAVMETPVG 420

Query: 421 DADASEGFSSPPSSLTSPSTPSSLGPSLSSTSGIGTSPSLRSLQSLLGPSSKFRHAQGTV 480
           DADASEGFSSPPSSLTSPSTPSSLGPSLSSTSGIGTSPSLRSLQSLLGPSSKFRHAQGTV
Sbjct: 421 DADASEGFSSPPSSLTSPSTPSSLGPSLSSTSGIGTSPSLRSLQSLLGPSSKFRHAQGTV 480

Query: 481 LHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVAVLELRKPGRLPDTALPT 540
           LHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVAVLELRKPGRLPDTALPT
Sbjct: 481 LHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVAVLELRKPGRLPDTALPT 540

Query: 541 LQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSL 600
           LQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSL
Sbjct: 541 LQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSL 600

Query: 601 RFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGR 660
           RFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGR
Sbjct: 601 RFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGR 660

Query: 661 VRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAEALAGG 720
           VRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAEALAGG
Sbjct: 661 VRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAEALAGG 720

Query: 721 PLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFLECNSFTSPDPHK 780
           PLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFLECNSFTSPDPHK
Sbjct: 721 PLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFLECNSFTSPDPHK 780

Query: 781 GLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTAVIWEPVLS 840
           GLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTAVIWEPVLS
Sbjct: 781 GLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTAVIWEPVLS 840

Query: 841 AEAWLQGANGQPWLLSLQPPDMSPVSQAPREAPARRAPSSAQYLEEKSDQQKKEELLNAM 900
           AEAWLQGANGQPWLLSLQPPDMSPVSQAPREAPARRAPSSAQYLEEKSDQQKKEELLNAM
Sbjct: 841 AEAWLQGANGQPWLLSLQPPDMSPVSQAPREAPARRAPSSAQYLEEKSDQQKKEELLNAM 900

Query: 901 VAKLGNREDPLPQDSFEGVDEDEWD 925
           VAKLGNREDPLPQDSFEGVDEDEWD
Sbjct: 901 VAKLGNREDPLPQDSFEGVDEDEWD 925


>gi|5902134 coronin, actin binding protein, 1A [Homo sapiens]
          Length = 461

 Score =  240 bits (613), Expect = 4e-63
 Identities = 155/456 (33%), Positives = 238/456 (52%), Gaps = 19/456 (4%)

Query: 470 SSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCA--NKLRVAVPLLSSGGQVAVLEL 527
           SSKFRH  G     D    +++    T      GFCA   K    +   S GG   VL L
Sbjct: 8   SSKFRHVFGQPAKADQCYEDVRVSQTTW---DSGFCAVNPKFVALICEASGGGAFLVLPL 64

Query: 528 RKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPE 587
            K GR+   A     + A V D+AW P + + +A   ED  + +W +P  GL   L  P 
Sbjct: 65  GKTGRVDKNAPTVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPLREPV 124

Query: 588 TVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKL--QGHQDQIFSLAW 645
             L GHT+++  + +H  A NVL S+  D  + +WD+  GA  L L  + H D I+S+ W
Sbjct: 125 VTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIYSVDW 184

Query: 646 SPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQS 705
           S DG  + T C+D RVR+  PR G    ++    +G R  R V+V +G+ +L +GF   S
Sbjct: 185 SRDGGLICTSCRDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGK-ILTTGFSRMS 243

Query: 706 ERQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESP 765
           ERQ+ L++ + L   PL++  LD +   LLP +DPDT +V L GKGD+ +  +E+  E+P
Sbjct: 244 ERQVALWDTKHLE-EPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAP 302

Query: 766 FFLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQD 825
           F    + F+S +  +G+  +PK   +V + E+ R  +L +   EP+A  +PR + + FQ+
Sbjct: 303 FLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERRCEPIAMTVPR-KSDLFQE 361

Query: 826 DVFPDTAVIWEPVLSAEAWLQGANGQPWLLSLQPPDMSPVSQAPR------EAPARRAPS 879
           D++P TA   +P L+AE WL G +  P L+SL+   + P S+  R          R AP 
Sbjct: 362 DLYPPTAGP-DPALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRGLDTGRRRAAPE 420

Query: 880 SAQYLEEKSDQQKKEEL--LNAMVAKLGNREDPLPQ 913
           ++      +  + +EE+  L A V +L  R D L +
Sbjct: 421 ASGTPSSDAVSRLEEEMRKLQATVQELQKRLDRLEE 456



 Score =  208 bits (530), Expect = 2e-53
 Identities = 130/424 (30%), Positives = 204/424 (48%), Gaps = 7/424 (1%)

Query: 5   RVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAF--NSDRPGVLGIVPLQG 62
           R SKFRH   +P + +    D+R             +   +A    +   G   ++PL  
Sbjct: 7   RSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVLPLGK 66

Query: 63  QGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALP-SAPGVV 121
            G   +    +  H+  V D+ + P +D ++A+GS D TV +W +P  G  LP   P V 
Sbjct: 67  TGRVDKNAPTVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPLREPVVT 126

Query: 122 LGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTELA--AHGDLVQSAVWSR 178
           L      V ++ +H T+  +L+SA     + VWD      +  L    H D + S  WSR
Sbjct: 127 LEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIYSVDWSR 186

Query: 179 DGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMRER 238
           DG L+ T+C+DK++RI +PR     ++  + HE +R  R  ++   + +++TGF++M ER
Sbjct: 187 DGGLICTSCRDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGK-ILTTGFSRMSER 245

Query: 239 EVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALS 298
           +V LWDT+     L+   LDTS G L+P  DPD+ ++ L GKG+  +  +E+  + P L 
Sbjct: 246 QVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLH 305

Query: 299 PVTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFP 358
            ++    +   RG   +P++ L V  CE+ R  +L +    PI   VPRK+  F EDL+P
Sbjct: 306 YLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERRCEPIAMTVPRKSDLFQEDLYP 365

Query: 359 DTAGCVPATDPHSWWAGDNQQVQKVSLNPACRPHPSFTSCLVPPAEPLPDTAQPAVMETP 418
            TAG  PA     W  G +     +SL     P  S    +    +     A P    TP
Sbjct: 366 PTAGPDPALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRGLDTGRRRAAPEASGTP 425

Query: 419 VGDA 422
             DA
Sbjct: 426 SSDA 429


>gi|65787364 coronin, actin binding protein, 1B [Homo sapiens]
          Length = 489

 Score =  235 bits (599), Expect = 2e-61
 Identities = 138/392 (35%), Positives = 212/392 (54%), Gaps = 12/392 (3%)

Query: 471 SKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCA--NKLRVAVPLLSSGGQVAVLELR 528
           SKFRH  G  +  D    +++   +T       FCA   K    +   S GG   VL L 
Sbjct: 10  SKFRHVFGQPVKNDQCYEDIRVSRVTWDST---FCAVNPKFLAVIVEASGGGAFLVLPLS 66

Query: 529 KPGRLPDTALPTL-QNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPE 587
           K GR+ D A PT+  +   V D+ W P +   +A   ED  + +W++P  GL   LT P 
Sbjct: 67  KTGRI-DKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPV 125

Query: 588 TVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQG-HQDQIFSLAWS 646
            VL GHT+++  + +HP A NVL S+  D  V IW++    +  +L   H D I++++W+
Sbjct: 126 VVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWN 185

Query: 647 PDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSE 706
            +G    + CKD  VR+  PR G    +     +G R  R +++ DG+ +  +GF   SE
Sbjct: 186 HNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGK-VFTTGFSRMSE 244

Query: 707 RQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPF 766
           RQL L++ E L   P+A+  LD +   LLP YDPDT +V + GKGD+ +  +E+  E P+
Sbjct: 245 RQLALWDPENLEE-PMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPY 303

Query: 767 FLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDD 826
               N+FTS +P +G+  +PK   +V + E+ R  +L +   EP+   +PR + + FQDD
Sbjct: 304 IHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPR-KSDLFQDD 362

Query: 827 VFPDTAVIWEPVLSAEAWLQGANGQPWLLSLQ 858
           ++PDTA   E  L AE W+ G +  P L+SL+
Sbjct: 363 LYPDTAGP-EAALEAEEWVSGRDADPILISLR 393



 Score =  205 bits (522), Expect = 1e-52
 Identities = 122/392 (31%), Positives = 201/392 (51%), Gaps = 6/392 (1%)

Query: 5   RVSKFRHTEARPPRRESWISDIRAG--TAPSCRNHIKSSCSLIAFNSDRPGVLGIVPLQG 62
           R SKFRH   +P + +    DIR    T  S    +      +   +   G   ++PL  
Sbjct: 8   RQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLSK 67

Query: 63  QGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALP-SAPGVV 121
            G   +    +  H+  V D+D+ P +D ++A+GS D TV +W++P  G   P + P VV
Sbjct: 68  TGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVV 127

Query: 122 LGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTEL-AAHGDLVQSAVWSRD 179
           L      V ++ +HPT+  +L+SA     V +W+    + L  L + H DL+ +  W+ +
Sbjct: 128 LEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHN 187

Query: 180 GALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMRERE 239
           G+L  +ACKDK +RI DPR     ++  +AHE +R  R  ++   + + +TGF++M ER+
Sbjct: 188 GSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGK-VFTTGFSRMSERQ 246

Query: 240 VKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSP 299
           + LWD       +A   LD+S G L+P  DPD+ ++ + GKG+  +  +E+  + P +  
Sbjct: 247 LALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPYIHF 306

Query: 300 VTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFPD 359
           +     +   RG   +P++ L V  CE+ R  +L +    PI   VPRK+  F +DL+PD
Sbjct: 307 LNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDLYPD 366

Query: 360 TAGCVPATDPHSWWAGDNQQVQKVSLNPACRP 391
           TAG   A +   W +G +     +SL  A  P
Sbjct: 367 TAGPEAALEAEEWVSGRDADPILISLREAYVP 398


>gi|14149734 coronin, actin binding protein, 1B [Homo sapiens]
          Length = 489

 Score =  235 bits (599), Expect = 2e-61
 Identities = 138/392 (35%), Positives = 212/392 (54%), Gaps = 12/392 (3%)

Query: 471 SKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCA--NKLRVAVPLLSSGGQVAVLELR 528
           SKFRH  G  +  D    +++   +T       FCA   K    +   S GG   VL L 
Sbjct: 10  SKFRHVFGQPVKNDQCYEDIRVSRVTWDST---FCAVNPKFLAVIVEASGGGAFLVLPLS 66

Query: 529 KPGRLPDTALPTL-QNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPE 587
           K GR+ D A PT+  +   V D+ W P +   +A   ED  + +W++P  GL   LT P 
Sbjct: 67  KTGRI-DKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPV 125

Query: 588 TVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQG-HQDQIFSLAWS 646
            VL GHT+++  + +HP A NVL S+  D  V IW++    +  +L   H D I++++W+
Sbjct: 126 VVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWN 185

Query: 647 PDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSE 706
            +G    + CKD  VR+  PR G    +     +G R  R +++ DG+ +  +GF   SE
Sbjct: 186 HNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGK-VFTTGFSRMSE 244

Query: 707 RQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPF 766
           RQL L++ E L   P+A+  LD +   LLP YDPDT +V + GKGD+ +  +E+  E P+
Sbjct: 245 RQLALWDPENLEE-PMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPY 303

Query: 767 FLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDD 826
               N+FTS +P +G+  +PK   +V + E+ R  +L +   EP+   +PR + + FQDD
Sbjct: 304 IHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPR-KSDLFQDD 362

Query: 827 VFPDTAVIWEPVLSAEAWLQGANGQPWLLSLQ 858
           ++PDTA   E  L AE W+ G +  P L+SL+
Sbjct: 363 LYPDTAGP-EAALEAEEWVSGRDADPILISLR 393



 Score =  205 bits (522), Expect = 1e-52
 Identities = 122/392 (31%), Positives = 201/392 (51%), Gaps = 6/392 (1%)

Query: 5   RVSKFRHTEARPPRRESWISDIRAG--TAPSCRNHIKSSCSLIAFNSDRPGVLGIVPLQG 62
           R SKFRH   +P + +    DIR    T  S    +      +   +   G   ++PL  
Sbjct: 8   RQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLSK 67

Query: 63  QGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALP-SAPGVV 121
            G   +    +  H+  V D+D+ P +D ++A+GS D TV +W++P  G   P + P VV
Sbjct: 68  TGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVV 127

Query: 122 LGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTEL-AAHGDLVQSAVWSRD 179
           L      V ++ +HPT+  +L+SA     V +W+    + L  L + H DL+ +  W+ +
Sbjct: 128 LEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHN 187

Query: 180 GALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMRERE 239
           G+L  +ACKDK +RI DPR     ++  +AHE +R  R  ++   + + +TGF++M ER+
Sbjct: 188 GSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGK-VFTTGFSRMSERQ 246

Query: 240 VKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSP 299
           + LWD       +A   LD+S G L+P  DPD+ ++ + GKG+  +  +E+  + P +  
Sbjct: 247 LALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPYIHF 306

Query: 300 VTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFPD 359
           +     +   RG   +P++ L V  CE+ R  +L +    PI   VPRK+  F +DL+PD
Sbjct: 307 LNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDLYPD 366

Query: 360 TAGCVPATDPHSWWAGDNQQVQKVSLNPACRP 391
           TAG   A +   W +G +     +SL  A  P
Sbjct: 367 TAGPEAALEAEEWVSGRDADPILISLREAYVP 398


>gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo
           sapiens]
          Length = 474

 Score =  233 bits (595), Expect = 5e-61
 Identities = 134/392 (34%), Positives = 213/392 (54%), Gaps = 12/392 (3%)

Query: 471 SKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLL--SSGGQVAVLELR 528
           SKFRH  G  +  D    +++   +T       FCA   R    ++  S GG   VL L 
Sbjct: 8   SKFRHVFGQAVKNDQCYDDIRVSRVTW---DSSFCAVNPRFVAIIIEASGGGAFLVLPLH 64

Query: 529 KPGRLPDTALPTL-QNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPE 587
           K GR+ D + PT+  +   V D+ W P +   +A   ED  + +W++P  GL   LT P 
Sbjct: 65  KTGRI-DKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPV 123

Query: 588 TVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQG-HQDQIFSLAWS 646
            +L GH++++  + +HP A NVL S+  D  + IW++  G   + L   H D I++++W+
Sbjct: 124 VILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWN 183

Query: 647 PDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSE 706
            +G  + T  KD +VRV  PR      ++    +G R  R +++ DG  +  +GF   SE
Sbjct: 184 RNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGN-VFTTGFSRMSE 242

Query: 707 RQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPF 766
           RQL L+  + +   P+A+  +D +   LLP YDPDT ++ L GKGD+ +  +E+  ESP+
Sbjct: 243 RQLALWNPKNMQE-PIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPY 301

Query: 767 FLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDD 826
               N+F+S +P +G+  +PK   DV + E+ R  +L +   EP+   +PR + + FQDD
Sbjct: 302 VHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPR-KSDLFQDD 360

Query: 827 VFPDTAVIWEPVLSAEAWLQGANGQPWLLSLQ 858
           ++PDTA   E  L AE W +G N  P L+SL+
Sbjct: 361 LYPDTAGP-EAALEAEEWFEGKNADPILISLK 391



 Score =  203 bits (516), Expect = 7e-52
 Identities = 118/386 (30%), Positives = 201/386 (52%), Gaps = 6/386 (1%)

Query: 5   RVSKFRHTEARPPRRESWISDIRAG--TAPSCRNHIKSSCSLIAFNSDRPGVLGIVPLQG 62
           R SKFRH   +  + +    DIR    T  S    +      I   +   G   ++PL  
Sbjct: 6   RQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHK 65

Query: 63  QGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALP-SAPGVV 121
            G   +    +  H+  V D+D+ P +D ++A+GS D TV +W++P  G  L  + P V+
Sbjct: 66  TGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVI 125

Query: 122 LGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTELA-AHGDLVQSAVWSRD 179
           L      V ++ +HPT+  +L+SA     + +W+    + L  L   H D++ +  W+R+
Sbjct: 126 LEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRN 185

Query: 180 GALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMRERE 239
           G+L+ TA KDK++R+ DPR +   ++  +AHE +R  R  ++    ++ +TGF++M ER+
Sbjct: 186 GSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADG-NVFTTGFSRMSERQ 244

Query: 240 VKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSP 299
           + LW+ +     +A   +DTS G L+P  DPD+ ++ L GKG+  +  +E+  + P +  
Sbjct: 245 LALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHY 304

Query: 300 VTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFPD 359
           +     +   RG   +P++ L V  CE+ R  +L +    PI   VPRK+  F +DL+PD
Sbjct: 305 LNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDDLYPD 364

Query: 360 TAGCVPATDPHSWWAGDNQQVQKVSL 385
           TAG   A +   W+ G N     +SL
Sbjct: 365 TAGPEAALEAEEWFEGKNADPILISL 390


>gi|109627650 coronin 6 [Homo sapiens]
          Length = 472

 Score =  219 bits (558), Expect = 9e-57
 Identities = 143/436 (32%), Positives = 218/436 (50%), Gaps = 27/436 (6%)

Query: 471 SKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVA--VLELR 528
           SKFRH  G     D    +++   +T       FCA   +    ++ +GG  A  VL L 
Sbjct: 9   SKFRHVFGQAAKADQAYEDIRVSKVTW---DSSFCAVNPKFLAIIVEAGGGGAFIVLPLA 65

Query: 529 KPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPET 588
           K GR+         + A V D+ W P + + +A A +D  I +W++P       +T P  
Sbjct: 66  KTGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPII 125

Query: 589 VLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQG-HQDQIFSLAWSP 647
            L GH++++  L +HP A NVL S+  D  + IW++  G   L L   H D I S+ W+ 
Sbjct: 126 TLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLDDMHPDVIHSVCWNS 185

Query: 648 DGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSER 707
           +G  LAT CKD  +R+  PR G    +     +G R  R V+   G  +  +GF   S+R
Sbjct: 186 NGSLLATTCKDKTLRIIDPRKGQVVAERFAAHEGMRPMRAVFTRQGH-IFTTGFTRMSQR 244

Query: 708 QLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFF 767
           +L L++       P+A+  +D +   LLP YDPD+ +V L GKGD+ +  +E+  E PF 
Sbjct: 245 ELGLWDPNNFEE-PVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFV 303

Query: 768 LECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDV 827
              N+F+S +P +G+  +PK   DV + E+ R  +L +   EP+   +PR + + FQDD+
Sbjct: 304 HYLNTFSSKEPQRGMGFMPKRGLDVSKCEIARFYKLHERKCEPIIMTVPR-KSDLFQDDL 362

Query: 828 FPDTAVIWEPVLSAEAWLQGANGQPWLLSLQ----PP-------------DMSPVSQAPR 870
           +PDT    EP L A+ WL G + +P L+SL+    PP             D+ P S   R
Sbjct: 363 YPDTPGP-EPALEADEWLSGQDAEPVLISLRDGYVPPKHRELRVTKRNILDVRPPSGPRR 421

Query: 871 EAPARRAPSSAQYLEE 886
              A  AP S Q+  E
Sbjct: 422 SQSASDAPLSQQHTLE 437



 Score =  201 bits (510), Expect = 3e-51
 Identities = 123/393 (31%), Positives = 196/393 (49%), Gaps = 8/393 (2%)

Query: 5   RVSKFRHTEARPPRRESWISDIRAG--TAPSCRNHIKSSCSLIAFNSDRPGVLGIVPLQG 62
           R SKFRH   +  + +    DIR    T  S    +      I   +   G   ++PL  
Sbjct: 7   RQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAK 66

Query: 63  QGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPG--PGQALPSAPGV 120
            G   +    +  H+  V D+D+ P +D ++A+ S D T+ +W++P   P + + + P +
Sbjct: 67  TGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNI-TEPII 125

Query: 121 VLGPEDLPVEVLQFHPTSDGILVSAAGTTVKV-WDAAKQQPLTELA-AHGDLVQSAVWSR 178
            L      V +L +HPT+  +L+SA G  V + W+    + L  L   H D++ S  W+ 
Sbjct: 126 TLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLDDMHPDVIHSVCWNS 185

Query: 179 DGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMRER 238
           +G+L+ T CKDK LRI DPR     ++   AHE  R  R  +     H+ +TGF +M +R
Sbjct: 186 NGSLLATTCKDKTLRIIDPRKGQVVAERFAAHEGMRPMRAVFTRQG-HIFTTGFTRMSQR 244

Query: 239 EVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALS 298
           E+ LWD   F   +A   +DTS G L+P  DPDS ++ L GKG+  +  +E+  + P + 
Sbjct: 245 ELGLWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVH 304

Query: 299 PVTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFP 358
            +     +   RG   +P++ L V  CE+ R  +L +    PI   VPRK+  F +DL+P
Sbjct: 305 YLNTFSSKEPQRGMGFMPKRGLDVSKCEIARFYKLHERKCEPIIMTVPRKSDLFQDDLYP 364

Query: 359 DTAGCVPATDPHSWWAGDNQQVQKVSLNPACRP 391
           DT G  PA +   W +G + +   +SL     P
Sbjct: 365 DTPGPEPALEADEWLSGQDAEPVLISLRDGYVP 397


>gi|209529711 coronin, actin binding protein, 2A [Homo sapiens]
          Length = 525

 Score =  210 bits (535), Expect = 4e-54
 Identities = 140/429 (32%), Positives = 226/429 (52%), Gaps = 20/429 (4%)

Query: 470 SSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCA-NKLRVAVPL-LSSGGQVAVLEL 527
           SSKFRH  G    +++   ++    +T     + FCA N   +AV    + GG   V+ L
Sbjct: 9   SSKFRHVFGKPASKENCYDSVP---ITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPL 65

Query: 528 RKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPE 587
            + G+L         +   V D+ W+PFD   +A   EDA I++W +P + L   LT   
Sbjct: 66  HQTGKLDPHYPKVCGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPKQLLTRNLTAYR 125

Query: 588 TVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRL-----KLQGHQDQIFS 642
             L GH  ++  + +HP AAN+L S+ YD  V IW+L      +      +  HQD I S
Sbjct: 126 KELVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMSTISCHQDVILS 185

Query: 643 LAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFD 702
           ++++ +G  LAT CKD ++RV  PR+G   LQE    KG R ++++++ + + L+ +G  
Sbjct: 186 MSFNTNGSLLATTCKDRKIRVIDPRAG-TVLQEA-SYKGHRASKVLFLGNLKKLMSTGTS 243

Query: 703 SQSERQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLP 762
             + RQ+ L++ + L+  PL    LD +   L P YD DT ++ + GKGD  +  YE+  
Sbjct: 244 RWNNRQVALWDQDNLS-VPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSA 302

Query: 763 ESPFFLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRL--RQSSLEPVAFRLPRVRK 820
           + P       + S +P KG+ ++PK   DV   E+ R  +L   +S +EP++  +PR R 
Sbjct: 303 DKPHLSYLTEYRSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPISMIVPR-RS 361

Query: 821 EFFQDDVFPDTAVIWEPVLSAEAWLQGANGQPWLLSLQP-PDMSPVSQAPREAPA--RRA 877
           E +Q+D++P TA   +P L+A+ WL G N  P L+SL+P  ++      P E P     A
Sbjct: 362 ESYQEDIYPPTAGA-QPSLTAQEWLSGMNRDPILVSLRPGSELLRPHPLPAERPIFNSMA 420

Query: 878 PSSAQYLEE 886
           P+S + L +
Sbjct: 421 PASPRLLNQ 429



 Score =  192 bits (487), Expect = 2e-48
 Identities = 126/426 (29%), Positives = 219/426 (51%), Gaps = 24/426 (5%)

Query: 3   RFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPG--VLGIVPL 60
           ++R SKFRH   +P  +E+    +    +    +    +   IA  ++  G     ++PL
Sbjct: 6   QYRSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPL 65

Query: 61  QGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGP--GQALPSAP 118
              G+       +  H   V D+ ++PFDDF +A+ S D T+K+W +P     + L +  
Sbjct: 66  HQTGKLDPHYPKVCGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPKQLLTRNLTAYR 125

Query: 119 GVVLGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQ-----PLTELAAHGDLVQ 172
             ++G     V ++++HPT+  IL SA     V +W+   ++     P++ ++ H D++ 
Sbjct: 126 KELVG-HARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMSTISCHQDVIL 184

Query: 173 SAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGF 232
           S  ++ +G+L+ T CKD+++R+ DPR      +++  ++  R S++ ++G  + L+STG 
Sbjct: 185 SMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEAS--YKGHRASKVLFLGNLKKLMSTGT 242

Query: 233 NQMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVP 292
           ++   R+V LWD    S  L    LD S G L P  D D+ +L + GKG+  +  YEV  
Sbjct: 243 SRWNNRQVALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSA 302

Query: 293 QQPALSPVTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDT--AIVPIGYHVPRKAV 350
            +P LS +T+    +  +G  ++P++ L V SCE+ R  +L  T   I PI   VPR++ 
Sbjct: 303 DKPHLSYLTEYRSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPISMIVPRRSE 362

Query: 351 EFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPA---CRPHPSFTSCLVPPAEPLP 407
            + ED++P TAG  P+     W +G N+    VSL P     RPHP      +P   P+ 
Sbjct: 363 SYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLRPGSELLRPHP------LPAERPIF 416

Query: 408 DTAQPA 413
           ++  PA
Sbjct: 417 NSMAPA 422


>gi|16554585 coronin, actin binding protein, 2A [Homo sapiens]
          Length = 525

 Score =  210 bits (535), Expect = 4e-54
 Identities = 140/429 (32%), Positives = 226/429 (52%), Gaps = 20/429 (4%)

Query: 470 SSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCA-NKLRVAVPL-LSSGGQVAVLEL 527
           SSKFRH  G    +++   ++    +T     + FCA N   +AV    + GG   V+ L
Sbjct: 9   SSKFRHVFGKPASKENCYDSVP---ITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPL 65

Query: 528 RKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPE 587
            + G+L         +   V D+ W+PFD   +A   EDA I++W +P + L   LT   
Sbjct: 66  HQTGKLDPHYPKVCGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPKQLLTRNLTAYR 125

Query: 588 TVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRL-----KLQGHQDQIFS 642
             L GH  ++  + +HP AAN+L S+ YD  V IW+L      +      +  HQD I S
Sbjct: 126 KELVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMSTISCHQDVILS 185

Query: 643 LAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFD 702
           ++++ +G  LAT CKD ++RV  PR+G   LQE    KG R ++++++ + + L+ +G  
Sbjct: 186 MSFNTNGSLLATTCKDRKIRVIDPRAG-TVLQEA-SYKGHRASKVLFLGNLKKLMSTGTS 243

Query: 703 SQSERQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLP 762
             + RQ+ L++ + L+  PL    LD +   L P YD DT ++ + GKGD  +  YE+  
Sbjct: 244 RWNNRQVALWDQDNLS-VPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSA 302

Query: 763 ESPFFLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRL--RQSSLEPVAFRLPRVRK 820
           + P       + S +P KG+ ++PK   DV   E+ R  +L   +S +EP++  +PR R 
Sbjct: 303 DKPHLSYLTEYRSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPISMIVPR-RS 361

Query: 821 EFFQDDVFPDTAVIWEPVLSAEAWLQGANGQPWLLSLQP-PDMSPVSQAPREAPA--RRA 877
           E +Q+D++P TA   +P L+A+ WL G N  P L+SL+P  ++      P E P     A
Sbjct: 362 ESYQEDIYPPTAGA-QPSLTAQEWLSGMNRDPILVSLRPGSELLRPHPLPAERPIFNSMA 420

Query: 878 PSSAQYLEE 886
           P+S + L +
Sbjct: 421 PASPRLLNQ 429



 Score =  192 bits (487), Expect = 2e-48
 Identities = 126/426 (29%), Positives = 219/426 (51%), Gaps = 24/426 (5%)

Query: 3   RFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPG--VLGIVPL 60
           ++R SKFRH   +P  +E+    +    +    +    +   IA  ++  G     ++PL
Sbjct: 6   QYRSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPL 65

Query: 61  QGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGP--GQALPSAP 118
              G+       +  H   V D+ ++PFDDF +A+ S D T+K+W +P     + L +  
Sbjct: 66  HQTGKLDPHYPKVCGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPKQLLTRNLTAYR 125

Query: 119 GVVLGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQ-----PLTELAAHGDLVQ 172
             ++G     V ++++HPT+  IL SA     V +W+   ++     P++ ++ H D++ 
Sbjct: 126 KELVG-HARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMSTISCHQDVIL 184

Query: 173 SAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGF 232
           S  ++ +G+L+ T CKD+++R+ DPR      +++  ++  R S++ ++G  + L+STG 
Sbjct: 185 SMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEAS--YKGHRASKVLFLGNLKKLMSTGT 242

Query: 233 NQMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVP 292
           ++   R+V LWD    S  L    LD S G L P  D D+ +L + GKG+  +  YEV  
Sbjct: 243 SRWNNRQVALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSA 302

Query: 293 QQPALSPVTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDT--AIVPIGYHVPRKAV 350
            +P LS +T+    +  +G  ++P++ L V SCE+ R  +L  T   I PI   VPR++ 
Sbjct: 303 DKPHLSYLTEYRSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPISMIVPRRSE 362

Query: 351 EFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPA---CRPHPSFTSCLVPPAEPLP 407
            + ED++P TAG  P+     W +G N+    VSL P     RPHP      +P   P+ 
Sbjct: 363 SYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLRPGSELLRPHP------LPAERPIF 416

Query: 408 DTAQPA 413
           ++  PA
Sbjct: 417 NSMAPA 422


>gi|148529011 coronin, actin binding protein, 2B [Homo sapiens]
          Length = 480

 Score =  209 bits (533), Expect = 7e-54
 Identities = 133/393 (33%), Positives = 203/393 (51%), Gaps = 12/393 (3%)

Query: 470 SSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSS--GGQVAVLEL 527
           SSKFR+  G V +R+       G+ +T     + FCA   R    +  S  GG   V+ L
Sbjct: 14  SSKFRNVYGKVANREHCFD---GIPITKNVHDNHFCAVNTRFLAIVTESAGGGSFLVIPL 70

Query: 528 RKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPE 587
            + GR+         +   V D+ W+PF  + +A   ED  +R+W +P  GL+  +T   
Sbjct: 71  EQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEAL 130

Query: 588 TVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSP 647
             L GH+ ++  + +HP   N+L S+ YD  V IW+L  G     +  H D I  ++++ 
Sbjct: 131 LELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNT 190

Query: 648 DGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSER 707
           DG  L T CKD ++RV  PRSG   LQE    K  R  R+V++ + + LL +G    + R
Sbjct: 191 DGSLLTTTCKDKKLRVIEPRSG-RVLQEA-NCKNHRVNRVVFLGNMKRLLTTGVSRWNTR 248

Query: 708 QLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFF 767
           Q+ L++ E L+  PL    +D     L P YD DT ++ L GKGD  +  YE+  E P+ 
Sbjct: 249 QIALWDQEDLS-MPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEKPYL 307

Query: 768 LECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRL--RQSSLEPVAFRLPRVRKEFFQD 825
                F SP P KGL ++PK   DV   E+ R  +L   +  +EP++  +PR R + +Q+
Sbjct: 308 SYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPR-RSDSYQE 366

Query: 826 DVFPDTAVIWEPVLSAEAWLQGANGQPWLLSLQ 858
           D++P T    EP L+ + WL G N  P L+SL+
Sbjct: 367 DIYPMTPGT-EPALTPDEWLGGINRDPVLMSLK 398



 Score =  177 bits (449), Expect = 4e-44
 Identities = 117/394 (29%), Positives = 198/394 (50%), Gaps = 18/394 (4%)

Query: 3   RFRVSKFRHTEARPPRRESWISDIRAGTAPSCRN-HIKSSCSL------IAFNSDRPGVL 55
           ++R SKFR+   +   RE     I     P  +N H    C++      I   S   G  
Sbjct: 11  QYRSSKFRNVYGKVANREHCFDGI-----PITKNVHDNHFCAVNTRFLAIVTESAGGGSF 65

Query: 56  GIVPLQGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALP 115
            ++PL+  G  +     +  H   V D+ ++PF D ++A+ S D +V++W +P  G    
Sbjct: 66  LVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRN 125

Query: 116 SAPGVV-LGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTELAAHGDLVQS 173
               ++ L      V ++++HPT++ IL SA     V +W+    +P+  +  H D++  
Sbjct: 126 MTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILC 185

Query: 174 AVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFN 233
             ++ DG+L+ T CKDK+LR+ +PR+  R  Q     +N R +R+ ++G  + L++TG +
Sbjct: 186 MSFNTDGSLLTTTCKDKKLRVIEPRSG-RVLQEANC-KNHRVNRVVFLGNMKRLLTTGVS 243

Query: 234 QMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQ 293
           +   R++ LWD    S  L    +D   G L P  D D+ +L LAGKG+  +  YE+  +
Sbjct: 244 RWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTE 303

Query: 294 QPALSPVTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDT--AIVPIGYHVPRKAVE 351
           +P LS + +    +  +G  ++P+  L V +CEV R  +L      I PI   VPR++  
Sbjct: 304 KPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRRSDS 363

Query: 352 FHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSL 385
           + ED++P T G  PA  P  W  G N+    +SL
Sbjct: 364 YQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSL 397


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 33/82 (40%), Positives = 51/82 (62%), Gaps = 1/82 (1%)

Query: 590 LTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDG 649
           L GH+E + S+ F P     LAS S D TVR WDL         +GH+  + S++WSPDG
Sbjct: 110 LEGHSEAVISVAFSP-TGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168

Query: 650 QQLATVCKDGRVRVYRPRSGPE 671
           ++LA+ CK+G++ ++ P +G +
Sbjct: 169 RKLASGCKNGQILLWDPSTGKQ 190



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 48/138 (34%), Positives = 71/138 (51%), Gaps = 11/138 (7%)

Query: 60  LQGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPG 119
           L    EDK+ +  +  H  L+  + FSP D  ++A+ S D+++KLW     G+ L S  G
Sbjct: 355 LWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD-GRTGKYLASLRG 412

Query: 120 VVLGPEDLPVEVLQFHPTSDG-ILVSAAG-TTVKVWDAAKQQPLTELAAHGDLVQSAVWS 177
            V         V Q   ++D  +LVS +  +T+KVWD   Q+   +L  H D V +  WS
Sbjct: 413 HVAA-------VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWS 465

Query: 178 RDGALVGTACKDKQLRIF 195
            DG  V +  KDK LRI+
Sbjct: 466 PDGQRVASGGKDKCLRIW 483



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 45/127 (35%), Positives = 64/127 (50%), Gaps = 12/127 (9%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLA 606
           V  ++W P D  +LA   ++ +I LW  P+ G +   T     L GH++ I  L + PL 
Sbjct: 159 VLSISWSP-DGRKLASGCKNGQILLWD-PSTGKQVGRT-----LAGHSKWITGLSWEPLH 211

Query: 607 AN----VLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVR 662
           AN     +ASSS D +VRIWD  AG     L GH   +  L W  DG  L +  +D  ++
Sbjct: 212 ANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIK 270

Query: 663 VYRPRSG 669
           V+R   G
Sbjct: 271 VWRAHDG 277



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 43/145 (29%), Positives = 71/145 (48%), Gaps = 37/145 (25%)

Query: 557 PHRLAVAGEDARIRLWRVPAEG-------------LEEVLTTPETVLT------------ 591
           P RL    +D  + LW  PAE              + +VL +P++ +             
Sbjct: 341 PERLVSGSDDFTLFLWS-PAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW 399

Query: 592 -GHTEK-ICSLRFHPLA---------ANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQI 640
            G T K + SLR H  A         + +L S S D T+++WD++A    + L GH D++
Sbjct: 400 DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEV 459

Query: 641 FSLAWSPDGQQLATVCKDGRVRVYR 665
           +++ WSPDGQ++A+  KD  +R++R
Sbjct: 460 YAVDWSPDGQRVASGGKDKCLRIWR 484



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 14/119 (11%)

Query: 134 FHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLR 193
           F PT   +   +  TTV+ WD + + P      H   V S  WS DG  + + CK+ Q+ 
Sbjct: 122 FSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQIL 181

Query: 194 IFDPRTKPRASQSTQAHENSRDSRLAWMG--TWEHLVSTG-----FNQMREREVKLWDT 245
           ++DP T  +  ++   H         W+   +WE L +        +  ++  V++WDT
Sbjct: 182 LWDPSTGKQVGRTLAGHSK-------WITGLSWEPLHANPECRYVASSSKDGSVRIWDT 233



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 31/106 (29%), Positives = 52/106 (49%), Gaps = 13/106 (12%)

Query: 547 VTDLAWDPFDPHR----LAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRF 602
           +T L+W+P   +     +A + +D  +R+W   A   E +LT       GHT+ +  LR+
Sbjct: 202 ITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILT-------GHTQSVTCLRW 254

Query: 603 HPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPD 648
                 +L S+S D T+++W    G     LQGH   + ++A S D
Sbjct: 255 G--GDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTD 298



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 30/111 (27%), Positives = 50/111 (45%), Gaps = 5/111 (4%)

Query: 93  LATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKV 152
           L +GS D T+ LW      + L      + G + L  +VL F P S  +  ++   ++K+
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTR----MTGHQALINQVL-FSPDSRIVASASFDKSIKL 398

Query: 153 WDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRA 203
           WD    + L  L  H   V    WS D  L+ +   D  L+++D + +  A
Sbjct: 399 WDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLA 449



 Score = 33.9 bits (76), Expect = 0.72
 Identities = 32/110 (29%), Positives = 54/110 (49%), Gaps = 11/110 (10%)

Query: 610 LASSSYDLTVRIWDLQAGADRL-KLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRS 668
           L S S D T+ +W        L ++ GHQ  I  + +SPD + +A+   D  ++++  R+
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 403

Query: 669 GPEPLQEGPGPKGGRGA--RIVWVCDGRCLLVSGFDSQSERQLLLYEAEA 716
           G    +     +G   A  +I W  D R LLVSG    S+  L +++ +A
Sbjct: 404 G----KYLASLRGHVAAVYQIAWSADSR-LLVSG---SSDSTLKVWDVKA 445



 Score = 33.5 bits (75), Expect = 0.94
 Identities = 31/126 (24%), Positives = 52/126 (41%), Gaps = 4/126 (3%)

Query: 72  HLGC--HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPV 129
           H  C  H   V  + +SP D   LA+G  +  + LW      Q   +  G       L  
Sbjct: 149 HFTCKGHRHWVLSISWSP-DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSW 207

Query: 130 EVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKD 189
           E L  +P    +  S+   +V++WD    +    L  H   V    W  DG L+ +A +D
Sbjct: 208 EPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQD 266

Query: 190 KQLRIF 195
           + ++++
Sbjct: 267 RTIKVW 272


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 52/160 (32%), Positives = 79/160 (49%), Gaps = 15/160 (9%)

Query: 557 PHRLAVAG-EDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSY 615
           P  L VAG +   IR+W + A    ++L T    L GH   ICSL FHP    V AS S 
Sbjct: 74  PEELIVAGSQSGSIRVWDLEAA---KILRT----LMGHKANICSLDFHPYGEFV-ASGSQ 125

Query: 616 DLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQE 675
           D  +++WD++      + +GH   +  L +SPDG+ LA+   D  V+++   +G + + E
Sbjct: 126 DTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG-KMMSE 184

Query: 676 GPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAE 715
            PG  G     +V       LL SG    S+R +  ++ E
Sbjct: 185 FPGHTG--PVNVVEFHPNEYLLASG---SSDRTIRFWDLE 219



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 39/120 (32%), Positives = 62/120 (51%), Gaps = 8/120 (6%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFH 135
           HS  V  L FSP D   LA+ + D TVKLW L   G+ +   PG        PV V++FH
Sbjct: 146 HSQAVRCLRFSP-DGKWLASAADDHTVKLWDLTA-GKMMSEFPG-----HTGPVNVVEFH 198

Query: 136 PTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIF 195
           P    +   ++  T++ WD  K Q ++ +      V+S +++ DG  + + C+D  LR++
Sbjct: 199 PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVY 257



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 39/119 (32%), Positives = 60/119 (50%), Gaps = 10/119 (8%)

Query: 546 AVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPL 605
           AV  L + P D   LA A +D  ++LW + A  +        +   GHT  +  + FHP 
Sbjct: 149 AVRCLRFSP-DGKWLASAADDHTVKLWDLTAGKMM-------SEFPGHTGPVNVVEFHP- 199

Query: 606 AANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
              +LAS S D T+R WDL+       ++G    + S+ ++PDG  L + C+D  +RVY
Sbjct: 200 NEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS-LRVY 257



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 42/176 (23%), Positives = 71/176 (40%), Gaps = 12/176 (6%)

Query: 69  RVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLP 128
           ++  +  H+  V+ L        LLATG  D  V LW +  P   +       L     P
Sbjct: 12  KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMS------LTGHTSP 65

Query: 129 VEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACK 188
           VE ++ +   + I+  +   +++VWD    + L  L  H   + S  +   G  V +  +
Sbjct: 66  VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQ 125

Query: 189 DKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLWD 244
           D  ++++D R K    +     +  R  R +  G W  L S       +  VKLWD
Sbjct: 126 DTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKW--LASAA----DDHTVKLWD 175



 Score = 30.4 bits (67), Expect = 7.9
 Identities = 15/75 (20%), Positives = 31/75 (41%)

Query: 590 LTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDG 649
           +  H   + SL     +  +LA+   D  V +W +      + L GH   + S+  +   
Sbjct: 16  IVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE 75

Query: 650 QQLATVCKDGRVRVY 664
           + +    + G +RV+
Sbjct: 76  ELIVAGSQSGSIRVW 90


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 38/131 (29%), Positives = 70/131 (53%), Gaps = 16/131 (12%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPL- 605
           V  + WDP     LA   +D  +++W +  +     L         H+++I ++++ P  
Sbjct: 362 VNAIKWDP-SGMLLASCSDDMTLKIWSMKQDACVHDLQA-------HSKEIYTIKWSPTG 413

Query: 606 -------AANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKD 658
                  ++ +LAS+S+D TVR+WD++ G     L  HQ+ ++S+A+SPDG+ LA+   D
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473

Query: 659 GRVRVYRPRSG 669
             V ++  +SG
Sbjct: 474 KYVHIWNTQSG 484



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 39/122 (31%), Positives = 54/122 (44%), Gaps = 17/122 (13%)

Query: 550 LAWDPFDPHR--------LAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLR 601
           + W P  P          LA A  D+ +RLW V     E+ + T    L  H E + S+ 
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDV-----EQGVCTH--TLMKHQEPVYSVA 459

Query: 602 FHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRV 661
           F P     LAS S+D  V IW+ Q+G+     QG    IF + W+  G ++     DG V
Sbjct: 460 FSP-DGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSV 517

Query: 662 RV 663
            V
Sbjct: 518 CV 519



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 41/140 (29%), Positives = 62/140 (44%), Gaps = 18/140 (12%)

Query: 577 EGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDL----QAGADRLK 632
           +G  E+     TVL GH  ++    ++P++ ++LAS S D T RIW+L      G+ +L 
Sbjct: 162 DGDVEIPPNKATVLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLV 220

Query: 633 LQ------GH----QDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGG 682
           L+      GH       + SL W+ DG  LA    DG  R++        L    G   G
Sbjct: 221 LRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKG 277

Query: 683 RGARIVWVCDGRCLLVSGFD 702
               + W   G  +L +G D
Sbjct: 278 PIFALKWNKKGNYVLSAGVD 297



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 36/142 (25%), Positives = 63/142 (44%), Gaps = 13/142 (9%)

Query: 70  VAHLGC---------HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPG--QALPSAP 118
           V  LGC         H++ V  + + P    LLA+ S D T+K+W +        L +  
Sbjct: 343 VCRLGCDHPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQDACVHDLQAHS 401

Query: 119 GVVLGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTELAAHGDLVQSAVWS 177
             +   +  P      +P S  +L SA+  +TV++WD  +      L  H + V S  +S
Sbjct: 402 KEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFS 461

Query: 178 RDGALVGTACKDKQLRIFDPRT 199
            DG  + +   DK + I++ ++
Sbjct: 462 PDGKYLASGSFDKYVHIWNTQS 483



 Score = 33.9 bits (76), Expect = 0.72
 Identities = 36/132 (27%), Positives = 54/132 (40%), Gaps = 10/132 (7%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRL----PGPGQALPSAPGVVLGPEDLP--V 129
           H   V    ++P  D LLA+GS D T ++W L     G    L     +  G  D+P   
Sbjct: 178 HESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236

Query: 130 EVLQFHPTSDGILVSAAGTT--VKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTAC 187
           +V      SDG L++        ++W        T L  H   + +  W++ G  V +A 
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIWTENGNLAST-LGQHKGPIFALKWNKKGNYVLSAG 295

Query: 188 KDKQLRIFDPRT 199
            DK   I+D  T
Sbjct: 296 VDKTTIIWDAHT 307



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 26/84 (30%), Positives = 39/84 (46%), Gaps = 12/84 (14%)

Query: 80  VTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSD 139
           VT LD++  D  LLA GS D   ++W   G   +        LG    P+  L+++   +
Sbjct: 238 VTSLDWNS-DGTLLAMGSYDGFARIWTENGNLAS-------TLGQHKGPIFALKWNKKGN 289

Query: 140 GILVSAAGTTVKVWDA----AKQQ 159
            +L +    T  +WDA    AKQQ
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQ 313



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 14/54 (25%), Positives = 27/54 (50%)

Query: 611 ASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
           AS S D+ + +  L         QGH +++ ++ W P G  LA+   D  ++++
Sbjct: 333 ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 34/134 (25%), Positives = 55/134 (41%), Gaps = 11/134 (8%)

Query: 551 AWDPFDPHRLAVAGEDARIRLWRVP--AEGLEEVLTTPETVLTG-----HTEKICSLRFH 603
           AW+P     LA    D+  R+W +   + G    L     +  G       + + SL ++
Sbjct: 186 AWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWN 244

Query: 604 PLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRV 663
                +LA  SYD   RIW  + G     L  H+  IF+L W+  G  + +   D    +
Sbjct: 245 S-DGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTII 302

Query: 664 YRPRSGPEPLQEGP 677
           +   +G E  Q+ P
Sbjct: 303 WDAHTG-EAKQQFP 315


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 38/131 (29%), Positives = 70/131 (53%), Gaps = 16/131 (12%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPL- 605
           V  + WDP     LA   +D  +++W +  +     L         H+++I ++++ P  
Sbjct: 362 VNAIKWDP-SGMLLASCSDDMTLKIWSMKQDACVHDLQA-------HSKEIYTIKWSPTG 413

Query: 606 -------AANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKD 658
                  ++ +LAS+S+D TVR+WD++ G     L  HQ+ ++S+A+SPDG+ LA+   D
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473

Query: 659 GRVRVYRPRSG 669
             V ++  +SG
Sbjct: 474 KYVHIWNTQSG 484



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 39/122 (31%), Positives = 54/122 (44%), Gaps = 17/122 (13%)

Query: 550 LAWDPFDPHR--------LAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLR 601
           + W P  P          LA A  D+ +RLW V     E+ + T    L  H E + S+ 
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDV-----EQGVCTH--TLMKHQEPVYSVA 459

Query: 602 FHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRV 661
           F P     LAS S+D  V IW+ Q+G+     QG    IF + W+  G ++     DG V
Sbjct: 460 FSP-DGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSV 517

Query: 662 RV 663
            V
Sbjct: 518 CV 519



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 41/140 (29%), Positives = 62/140 (44%), Gaps = 18/140 (12%)

Query: 577 EGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDL----QAGADRLK 632
           +G  E+     TVL GH  ++    ++P++ ++LAS S D T RIW+L      G+ +L 
Sbjct: 162 DGDVEIPPNKATVLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLV 220

Query: 633 LQ------GH----QDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGG 682
           L+      GH       + SL W+ DG  LA    DG  R++        L    G   G
Sbjct: 221 LRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKG 277

Query: 683 RGARIVWVCDGRCLLVSGFD 702
               + W   G  +L +G D
Sbjct: 278 PIFALKWNKKGNYVLSAGVD 297



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 36/142 (25%), Positives = 63/142 (44%), Gaps = 13/142 (9%)

Query: 70  VAHLGC---------HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPG--QALPSAP 118
           V  LGC         H++ V  + + P    LLA+ S D T+K+W +        L +  
Sbjct: 343 VCRLGCDHPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQDACVHDLQAHS 401

Query: 119 GVVLGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTELAAHGDLVQSAVWS 177
             +   +  P      +P S  +L SA+  +TV++WD  +      L  H + V S  +S
Sbjct: 402 KEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFS 461

Query: 178 RDGALVGTACKDKQLRIFDPRT 199
            DG  + +   DK + I++ ++
Sbjct: 462 PDGKYLASGSFDKYVHIWNTQS 483



 Score = 33.9 bits (76), Expect = 0.72
 Identities = 36/132 (27%), Positives = 54/132 (40%), Gaps = 10/132 (7%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRL----PGPGQALPSAPGVVLGPEDLP--V 129
           H   V    ++P  D LLA+GS D T ++W L     G    L     +  G  D+P   
Sbjct: 178 HESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236

Query: 130 EVLQFHPTSDGILVSAAGTT--VKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTAC 187
           +V      SDG L++        ++W        T L  H   + +  W++ G  V +A 
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIWTENGNLAST-LGQHKGPIFALKWNKKGNYVLSAG 295

Query: 188 KDKQLRIFDPRT 199
            DK   I+D  T
Sbjct: 296 VDKTTIIWDAHT 307



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 26/84 (30%), Positives = 39/84 (46%), Gaps = 12/84 (14%)

Query: 80  VTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSD 139
           VT LD++  D  LLA GS D   ++W   G   +        LG    P+  L+++   +
Sbjct: 238 VTSLDWNS-DGTLLAMGSYDGFARIWTENGNLAS-------TLGQHKGPIFALKWNKKGN 289

Query: 140 GILVSAAGTTVKVWDA----AKQQ 159
            +L +    T  +WDA    AKQQ
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQ 313



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 14/54 (25%), Positives = 27/54 (50%)

Query: 611 ASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
           AS S D+ + +  L         QGH +++ ++ W P G  LA+   D  ++++
Sbjct: 333 ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 34/134 (25%), Positives = 55/134 (41%), Gaps = 11/134 (8%)

Query: 551 AWDPFDPHRLAVAGEDARIRLWRVP--AEGLEEVLTTPETVLTG-----HTEKICSLRFH 603
           AW+P     LA    D+  R+W +   + G    L     +  G       + + SL ++
Sbjct: 186 AWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWN 244

Query: 604 PLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRV 663
                +LA  SYD   RIW  + G     L  H+  IF+L W+  G  + +   D    +
Sbjct: 245 S-DGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTII 302

Query: 664 YRPRSGPEPLQEGP 677
           +   +G E  Q+ P
Sbjct: 303 WDAHTG-EAKQQFP 315


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 38/131 (29%), Positives = 70/131 (53%), Gaps = 16/131 (12%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPL- 605
           V  + WDP     LA   +D  +++W +  +     L         H+++I ++++ P  
Sbjct: 362 VNAIKWDP-SGMLLASCSDDMTLKIWSMKQDACVHDLQA-------HSKEIYTIKWSPTG 413

Query: 606 -------AANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKD 658
                  ++ +LAS+S+D TVR+WD++ G     L  HQ+ ++S+A+SPDG+ LA+   D
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473

Query: 659 GRVRVYRPRSG 669
             V ++  +SG
Sbjct: 474 KYVHIWNTQSG 484



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 39/122 (31%), Positives = 54/122 (44%), Gaps = 17/122 (13%)

Query: 550 LAWDPFDPHR--------LAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLR 601
           + W P  P          LA A  D+ +RLW V     E+ + T    L  H E + S+ 
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDV-----EQGVCTH--TLMKHQEPVYSVA 459

Query: 602 FHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRV 661
           F P     LAS S+D  V IW+ Q+G+     QG    IF + W+  G ++     DG V
Sbjct: 460 FSP-DGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSV 517

Query: 662 RV 663
            V
Sbjct: 518 CV 519



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 41/140 (29%), Positives = 62/140 (44%), Gaps = 18/140 (12%)

Query: 577 EGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDL----QAGADRLK 632
           +G  E+     TVL GH  ++    ++P++ ++LAS S D T RIW+L      G+ +L 
Sbjct: 162 DGDVEIPPNKATVLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLV 220

Query: 633 LQ------GH----QDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGG 682
           L+      GH       + SL W+ DG  LA    DG  R++        L    G   G
Sbjct: 221 LRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKG 277

Query: 683 RGARIVWVCDGRCLLVSGFD 702
               + W   G  +L +G D
Sbjct: 278 PIFALKWNKKGNYVLSAGVD 297



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 36/142 (25%), Positives = 63/142 (44%), Gaps = 13/142 (9%)

Query: 70  VAHLGC---------HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPG--QALPSAP 118
           V  LGC         H++ V  + + P    LLA+ S D T+K+W +        L +  
Sbjct: 343 VCRLGCDHPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQDACVHDLQAHS 401

Query: 119 GVVLGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTELAAHGDLVQSAVWS 177
             +   +  P      +P S  +L SA+  +TV++WD  +      L  H + V S  +S
Sbjct: 402 KEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFS 461

Query: 178 RDGALVGTACKDKQLRIFDPRT 199
            DG  + +   DK + I++ ++
Sbjct: 462 PDGKYLASGSFDKYVHIWNTQS 483



 Score = 33.9 bits (76), Expect = 0.72
 Identities = 36/132 (27%), Positives = 54/132 (40%), Gaps = 10/132 (7%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRL----PGPGQALPSAPGVVLGPEDLP--V 129
           H   V    ++P  D LLA+GS D T ++W L     G    L     +  G  D+P   
Sbjct: 178 HESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236

Query: 130 EVLQFHPTSDGILVSAAGTT--VKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTAC 187
           +V      SDG L++        ++W        T L  H   + +  W++ G  V +A 
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIWTENGNLAST-LGQHKGPIFALKWNKKGNYVLSAG 295

Query: 188 KDKQLRIFDPRT 199
            DK   I+D  T
Sbjct: 296 VDKTTIIWDAHT 307



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 26/84 (30%), Positives = 39/84 (46%), Gaps = 12/84 (14%)

Query: 80  VTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSD 139
           VT LD++  D  LLA GS D   ++W   G   +        LG    P+  L+++   +
Sbjct: 238 VTSLDWNS-DGTLLAMGSYDGFARIWTENGNLAS-------TLGQHKGPIFALKWNKKGN 289

Query: 140 GILVSAAGTTVKVWDA----AKQQ 159
            +L +    T  +WDA    AKQQ
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQ 313



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 14/54 (25%), Positives = 27/54 (50%)

Query: 611 ASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
           AS S D+ + +  L         QGH +++ ++ W P G  LA+   D  ++++
Sbjct: 333 ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 34/134 (25%), Positives = 55/134 (41%), Gaps = 11/134 (8%)

Query: 551 AWDPFDPHRLAVAGEDARIRLWRVP--AEGLEEVLTTPETVLTG-----HTEKICSLRFH 603
           AW+P     LA    D+  R+W +   + G    L     +  G       + + SL ++
Sbjct: 186 AWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWN 244

Query: 604 PLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRV 663
                +LA  SYD   RIW  + G     L  H+  IF+L W+  G  + +   D    +
Sbjct: 245 S-DGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTII 302

Query: 664 YRPRSGPEPLQEGP 677
           +   +G E  Q+ P
Sbjct: 303 WDAHTG-EAKQQFP 315


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 41/123 (33%), Positives = 61/123 (49%), Gaps = 9/123 (7%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLA 606
           V DL   P+  +  A    D   RLW           T P  +  GH   +  ++FHP  
Sbjct: 387 VWDLDISPYSLY-FASGSHDRTARLWSFDR-------TYPLRIYAGHLADVDCVKFHP-N 437

Query: 607 ANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRP 666
           +N LA+ S D TVR+W  Q G       GH+  + SLA+SP+G+ LA+  +D R++++  
Sbjct: 438 SNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDL 497

Query: 667 RSG 669
            SG
Sbjct: 498 ASG 500



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 37/109 (33%), Positives = 52/109 (47%), Gaps = 8/109 (7%)

Query: 560 LAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTV 619
           LA    D  +RLW         + T       GH   + SL F P     LAS+  D  +
Sbjct: 441 LATGSTDKTVRLWSAQQGNSVRLFT-------GHRGPVLSLAFSP-NGKYLASAGEDQRL 492

Query: 620 RIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRS 668
           ++WDL +G    +L+GH D I SL +SPD   +A+   D  VRV+  R+
Sbjct: 493 KLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 34/121 (28%), Positives = 61/121 (50%), Gaps = 7/121 (5%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFH 135
           H+  V DLD SP+  +  A+GS DRT +LW          + P  +       V+ ++FH
Sbjct: 383 HAYPVWDLDISPYSLYF-ASGSHDRTARLWSFD------RTYPLRIYAGHLADVDCVKFH 435

Query: 136 PTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIF 195
           P S+ +   +   TV++W A +   +     H   V S  +S +G  + +A +D++L+++
Sbjct: 436 PNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLW 495

Query: 196 D 196
           D
Sbjct: 496 D 496



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 40/133 (30%), Positives = 61/133 (45%), Gaps = 10/133 (7%)

Query: 69  RVAHLGCHSDLVTDLD---FSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPE 125
           R   L  ++  + D+D   F P  ++L ATGS D+TV+LW     G ++    G      
Sbjct: 415 RTYPLRIYAGHLADVDCVKFHPNSNYL-ATGSTDKTVRLWSAQ-QGNSVRLFTG-----H 467

Query: 126 DLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGT 185
             PV  L F P    +  +     +K+WD A      EL  H D + S  +S D  L+ +
Sbjct: 468 RGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIAS 527

Query: 186 ACKDKQLRIFDPR 198
           A  D  +R++D R
Sbjct: 528 ASMDNSVRVWDIR 540



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 24/80 (30%), Positives = 40/80 (50%), Gaps = 1/80 (1%)

Query: 585 TPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLA 644
           T   +L GH   + S RF   ++ +L S S D+++R WDL +  + +  QGH   ++ L 
Sbjct: 333 TEMKILRGHCGPVYSTRFLADSSGLL-SCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLD 391

Query: 645 WSPDGQQLATVCKDGRVRVY 664
            SP     A+   D   R++
Sbjct: 392 ISPYSLYFASGSHDRTARLW 411


>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
           sapiens]
          Length = 390

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 45/170 (26%), Positives = 77/170 (45%), Gaps = 15/170 (8%)

Query: 529 KPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPET 588
           K G++ D       + A V D++W            +D ++ +W   +    +    P  
Sbjct: 177 KEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSK----PSH 232

Query: 589 VLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRL-KLQGHQDQIFSLAWSP 647
            +  HT ++  L F+P +  +LA+ S D TV +WDL+    +L   + H+D+IF + WSP
Sbjct: 233 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 292

Query: 648 DGQQ-LATVCKDGRVRVY-----RPRSGPEPLQEGPGP----KGGRGARI 687
             +  LA+   D R+ V+          PE  ++GP       GG  A+I
Sbjct: 293 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 342



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 29/83 (34%), Positives = 43/83 (51%), Gaps = 6/83 (7%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFH 135
           H+  V  L F+P+ +F+LATGSAD+TV LW L      L S            +  +Q+ 
Sbjct: 237 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS-----FESHKDEIFQVQWS 291

Query: 136 PTSDGILVSA-AGTTVKVWDAAK 157
           P ++ IL S+     + VWD +K
Sbjct: 292 PHNETILASSGTDRRLNVWDLSK 314



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 31/136 (22%), Positives = 61/136 (44%), Gaps = 21/136 (15%)

Query: 545 AAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHP 604
           A V  L+++P+    LA    D  + LW +    L+  L + E+    H ++I  +++ P
Sbjct: 239 AEVNCLSFNPYSEFILATGSADKTVALWDL--RNLKLKLHSFES----HKDEIFQVQWSP 292

Query: 605 LAANVLASSSYDLTVRIWDLQAGADRLKLQ--------------GHQDQIFSLAWSP-DG 649
               +LASS  D  + +WDL    +    +              GH  +I   +W+P + 
Sbjct: 293 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 352

Query: 650 QQLATVCKDGRVRVYR 665
             + +V +D  ++V++
Sbjct: 353 WVICSVSEDNIMQVWQ 368



 Score = 37.0 bits (84), Expect = 0.085
 Identities = 22/85 (25%), Positives = 38/85 (44%), Gaps = 7/85 (8%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPET-------VLTGHTEKICS 599
           +  + W P +   LA +G D R+ +W +   G E+     E        +  GHT KI  
Sbjct: 285 IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISD 344

Query: 600 LRFHPLAANVLASSSYDLTVRIWDL 624
             ++P    V+ S S D  +++W +
Sbjct: 345 FSWNPNEPWVICSVSEDNIMQVWQM 369



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 23/91 (25%), Positives = 43/91 (47%), Gaps = 8/91 (8%)

Query: 586 PETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKL-------QGHQD 638
           P+  L GH ++   L ++P  +  L S+S D T+ +WD+ A     K+        GH  
Sbjct: 134 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 193

Query: 639 QIFSLAWSPDGQQL-ATVCKDGRVRVYRPRS 668
            +  ++W    + L  +V  D ++ ++  RS
Sbjct: 194 VVEDVSWHLLHESLFGSVADDQKLMIWDTRS 224



 Score = 30.4 bits (67), Expect = 7.9
 Identities = 17/60 (28%), Positives = 28/60 (46%), Gaps = 5/60 (8%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFH 135
           H D +  + +SP ++ +LA+   DR + +W L   G+            ED P E+L  H
Sbjct: 281 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA-----EDGPPELLFIH 335


>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
           sapiens]
          Length = 424

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 45/170 (26%), Positives = 77/170 (45%), Gaps = 15/170 (8%)

Query: 529 KPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPET 588
           K G++ D       + A V D++W            +D ++ +W   +    +    P  
Sbjct: 211 KEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSK----PSH 266

Query: 589 VLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRL-KLQGHQDQIFSLAWSP 647
            +  HT ++  L F+P +  +LA+ S D TV +WDL+    +L   + H+D+IF + WSP
Sbjct: 267 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 326

Query: 648 DGQQ-LATVCKDGRVRVY-----RPRSGPEPLQEGPGP----KGGRGARI 687
             +  LA+   D R+ V+          PE  ++GP       GG  A+I
Sbjct: 327 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 376



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 29/83 (34%), Positives = 43/83 (51%), Gaps = 6/83 (7%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFH 135
           H+  V  L F+P+ +F+LATGSAD+TV LW L      L S            +  +Q+ 
Sbjct: 271 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS-----FESHKDEIFQVQWS 325

Query: 136 PTSDGILVSA-AGTTVKVWDAAK 157
           P ++ IL S+     + VWD +K
Sbjct: 326 PHNETILASSGTDRRLNVWDLSK 348



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 31/136 (22%), Positives = 61/136 (44%), Gaps = 21/136 (15%)

Query: 545 AAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHP 604
           A V  L+++P+    LA    D  + LW +    L+  L + E+    H ++I  +++ P
Sbjct: 273 AEVNCLSFNPYSEFILATGSADKTVALWDL--RNLKLKLHSFES----HKDEIFQVQWSP 326

Query: 605 LAANVLASSSYDLTVRIWDLQAGADRLKLQ--------------GHQDQIFSLAWSP-DG 649
               +LASS  D  + +WDL    +    +              GH  +I   +W+P + 
Sbjct: 327 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 386

Query: 650 QQLATVCKDGRVRVYR 665
             + +V +D  ++V++
Sbjct: 387 WVICSVSEDNIMQVWQ 402



 Score = 37.0 bits (84), Expect = 0.085
 Identities = 22/85 (25%), Positives = 38/85 (44%), Gaps = 7/85 (8%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPET-------VLTGHTEKICS 599
           +  + W P +   LA +G D R+ +W +   G E+     E        +  GHT KI  
Sbjct: 319 IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISD 378

Query: 600 LRFHPLAANVLASSSYDLTVRIWDL 624
             ++P    V+ S S D  +++W +
Sbjct: 379 FSWNPNEPWVICSVSEDNIMQVWQM 403



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 23/91 (25%), Positives = 43/91 (47%), Gaps = 8/91 (8%)

Query: 586 PETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKL-------QGHQD 638
           P+  L GH ++   L ++P  +  L S+S D T+ +WD+ A     K+        GH  
Sbjct: 168 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 227

Query: 639 QIFSLAWSPDGQQL-ATVCKDGRVRVYRPRS 668
            +  ++W    + L  +V  D ++ ++  RS
Sbjct: 228 VVEDVSWHLLHESLFGSVADDQKLMIWDTRS 258



 Score = 30.4 bits (67), Expect = 7.9
 Identities = 17/60 (28%), Positives = 28/60 (46%), Gaps = 5/60 (8%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFH 135
           H D +  + +SP ++ +LA+   DR + +W L   G+            ED P E+L  H
Sbjct: 315 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA-----EDGPPELLFIH 369


>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
           sapiens]
          Length = 425

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 45/170 (26%), Positives = 77/170 (45%), Gaps = 15/170 (8%)

Query: 529 KPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPET 588
           K G++ D       + A V D++W            +D ++ +W   +    +    P  
Sbjct: 212 KEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSK----PSH 267

Query: 589 VLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRL-KLQGHQDQIFSLAWSP 647
            +  HT ++  L F+P +  +LA+ S D TV +WDL+    +L   + H+D+IF + WSP
Sbjct: 268 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 327

Query: 648 DGQQ-LATVCKDGRVRVY-----RPRSGPEPLQEGPGP----KGGRGARI 687
             +  LA+   D R+ V+          PE  ++GP       GG  A+I
Sbjct: 328 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 377



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 29/83 (34%), Positives = 43/83 (51%), Gaps = 6/83 (7%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFH 135
           H+  V  L F+P+ +F+LATGSAD+TV LW L      L S            +  +Q+ 
Sbjct: 272 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS-----FESHKDEIFQVQWS 326

Query: 136 PTSDGILVSA-AGTTVKVWDAAK 157
           P ++ IL S+     + VWD +K
Sbjct: 327 PHNETILASSGTDRRLNVWDLSK 349



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 31/136 (22%), Positives = 61/136 (44%), Gaps = 21/136 (15%)

Query: 545 AAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHP 604
           A V  L+++P+    LA    D  + LW +    L+  L + E+    H ++I  +++ P
Sbjct: 274 AEVNCLSFNPYSEFILATGSADKTVALWDL--RNLKLKLHSFES----HKDEIFQVQWSP 327

Query: 605 LAANVLASSSYDLTVRIWDLQAGADRLKLQ--------------GHQDQIFSLAWSP-DG 649
               +LASS  D  + +WDL    +    +              GH  +I   +W+P + 
Sbjct: 328 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 387

Query: 650 QQLATVCKDGRVRVYR 665
             + +V +D  ++V++
Sbjct: 388 WVICSVSEDNIMQVWQ 403



 Score = 37.0 bits (84), Expect = 0.085
 Identities = 22/85 (25%), Positives = 38/85 (44%), Gaps = 7/85 (8%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPET-------VLTGHTEKICS 599
           +  + W P +   LA +G D R+ +W +   G E+     E        +  GHT KI  
Sbjct: 320 IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISD 379

Query: 600 LRFHPLAANVLASSSYDLTVRIWDL 624
             ++P    V+ S S D  +++W +
Sbjct: 380 FSWNPNEPWVICSVSEDNIMQVWQM 404



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 23/91 (25%), Positives = 43/91 (47%), Gaps = 8/91 (8%)

Query: 586 PETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKL-------QGHQD 638
           P+  L GH ++   L ++P  +  L S+S D T+ +WD+ A     K+        GH  
Sbjct: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 228

Query: 639 QIFSLAWSPDGQQL-ATVCKDGRVRVYRPRS 668
            +  ++W    + L  +V  D ++ ++  RS
Sbjct: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRS 259



 Score = 30.4 bits (67), Expect = 7.9
 Identities = 17/60 (28%), Positives = 28/60 (46%), Gaps = 5/60 (8%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFH 135
           H D +  + +SP ++ +LA+   DR + +W L   G+            ED P E+L  H
Sbjct: 316 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA-----EDGPPELLFIH 370


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 41/131 (31%), Positives = 71/131 (54%), Gaps = 16/131 (12%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLA 606
           V  + WDP     LA   +D  +++W +     +EV       L  H ++I ++++ P  
Sbjct: 364 VNAIKWDP-SGMLLASCSDDMTLKIWSMK----QEVCIHD---LQAHNKEIYTIKWSPTG 415

Query: 607 -------ANV-LASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKD 658
                  +N+ LAS+S+D TVR+WD++ G     L  HQ+ ++S+A+SPDG+ LA+   D
Sbjct: 416 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 475

Query: 659 GRVRVYRPRSG 669
             V ++  +SG
Sbjct: 476 KCVHIWNTQSG 486



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 41/140 (29%), Positives = 65/140 (46%), Gaps = 18/140 (12%)

Query: 577 EGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDL----QAGADRLK 632
           +G  E+ ++  TVL GH  ++    ++P++ ++LAS S D T RIW+L      G+ +L 
Sbjct: 164 DGEVEIPSSKATVLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLV 222

Query: 633 LQ------GH----QDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGG 682
           L+      GH       + SL W+ +G  LAT   DG  R++        L    G   G
Sbjct: 223 LRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQHKG 279

Query: 683 RGARIVWVCDGRCLLVSGFD 702
               + W   G  +L +G D
Sbjct: 280 PIFALKWNRKGNYILSAGVD 299



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 38/122 (31%), Positives = 53/122 (43%), Gaps = 17/122 (13%)

Query: 550 LAWDPFDPHR--------LAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLR 601
           + W P  P          LA A  D+ +RLW +     E  + T    LT H E + S+ 
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDI-----ERGVCTH--TLTKHQEPVYSVA 461

Query: 602 FHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRV 661
           F P     LAS S+D  V IW+ Q+G      +G    IF + W+  G ++     DG V
Sbjct: 462 FSP-DGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 519

Query: 662 RV 663
            V
Sbjct: 520 CV 521



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 36/142 (25%), Positives = 64/142 (45%), Gaps = 13/142 (9%)

Query: 70  VAHLGC---------HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPG--QALPSAP 118
           V  LGC         H++ V  + + P    LLA+ S D T+K+W +        L +  
Sbjct: 345 VCRLGCDRPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHN 403

Query: 119 GVVLGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTELAAHGDLVQSAVWS 177
             +   +  P      +P S+ +L SA+  +TV++WD  +      L  H + V S  +S
Sbjct: 404 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFS 463

Query: 178 RDGALVGTACKDKQLRIFDPRT 199
            DG  + +   DK + I++ ++
Sbjct: 464 PDGKYLASGSFDKCVHIWNTQS 485



 Score = 34.7 bits (78), Expect = 0.42
 Identities = 48/211 (22%), Positives = 74/211 (35%), Gaps = 56/211 (26%)

Query: 80  VTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSD 139
           VT LD++  +  LLATGS D   ++W   G   +        LG    P+  L+++   +
Sbjct: 240 VTSLDWNT-NGTLLATGSYDGFARIWTEDGNLAS-------TLGQHKGPIFALKWNRKGN 291

Query: 140 GILVSAAGTTVKVWDA----AKQQ------------------------------------ 159
            IL +    T  +WDA    AKQQ                                    
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 351

Query: 160 -PLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRL 218
            P+     H + V +  W   G L+ +   D  L+I+  + +       QAH N     +
Sbjct: 352 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEV-CIHDLQAH-NKEIYTI 409

Query: 219 AWMGTWEHLVSTGFNQMR-----EREVKLWD 244
            W  T     +   N M      +  V+LWD
Sbjct: 410 KWSPTGPATSNPNSNIMLASASFDSTVRLWD 440



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 14/54 (25%), Positives = 27/54 (50%)

Query: 611 ASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
           AS S D+ + +  L         QGH +++ ++ W P G  LA+   D  ++++
Sbjct: 335 ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 34/132 (25%), Positives = 54/132 (40%), Gaps = 10/132 (7%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRL----PGPGQALPSAPGVVLGPEDLP--V 129
           H   V    ++P  D LLA+GS D T ++W L     G    L     +  G  D+P   
Sbjct: 180 HESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 238

Query: 130 EVLQFHPTSDGILVSAAGTT--VKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTAC 187
           +V      ++G L++        ++W        T L  H   + +  W+R G  + +A 
Sbjct: 239 DVTSLDWNTNGTLLATGSYDGFARIWTEDGNLAST-LGQHKGPIFALKWNRKGNYILSAG 297

Query: 188 KDKQLRIFDPRT 199
            DK   I+D  T
Sbjct: 298 VDKTTIIWDAHT 309



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 34/134 (25%), Positives = 56/134 (41%), Gaps = 11/134 (8%)

Query: 551 AWDPFDPHRLAVAGEDARIRLWRVP--AEGLEEVLTTPETVLTG-----HTEKICSLRFH 603
           AW+P     LA    D+  R+W +   + G    L     +  G       + + SL ++
Sbjct: 188 AWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWN 246

Query: 604 PLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRV 663
                +LA+ SYD   RIW  + G     L  H+  IF+L W+  G  + +   D    +
Sbjct: 247 T-NGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTII 304

Query: 664 YRPRSGPEPLQEGP 677
           +   +G E  Q+ P
Sbjct: 305 WDAHTG-EAKQQFP 317



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 31/145 (21%), Positives = 55/145 (37%), Gaps = 21/145 (14%)

Query: 114 LPSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWD-------AAKQQPLTELAA 166
           +PS+   VL   +  V +  ++P SD +   +  +T ++W+        + Q  L     
Sbjct: 169 IPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIR 228

Query: 167 HGDL-------VQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLA 219
            G         V S  W+ +G L+ T   D   RI+   T+     ST          L 
Sbjct: 229 EGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALK 285

Query: 220 WMGTWEHLVSTGFNQMREREVKLWD 244
           W     +++S G     ++   +WD
Sbjct: 286 WNRKGNYILSAGV----DKTTIIWD 306


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 41/131 (31%), Positives = 71/131 (54%), Gaps = 16/131 (12%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLA 606
           V  + WDP     LA   +D  +++W +     +EV       L  H ++I ++++ P  
Sbjct: 364 VNAIKWDP-SGMLLASCSDDMTLKIWSMK----QEVCIHD---LQAHNKEIYTIKWSPTG 415

Query: 607 -------ANV-LASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKD 658
                  +N+ LAS+S+D TVR+WD++ G     L  HQ+ ++S+A+SPDG+ LA+   D
Sbjct: 416 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 475

Query: 659 GRVRVYRPRSG 669
             V ++  +SG
Sbjct: 476 KCVHIWNTQSG 486



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 41/140 (29%), Positives = 65/140 (46%), Gaps = 18/140 (12%)

Query: 577 EGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDL----QAGADRLK 632
           +G  E+ ++  TVL GH  ++    ++P++ ++LAS S D T RIW+L      G+ +L 
Sbjct: 164 DGEVEIPSSKATVLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLV 222

Query: 633 LQ------GH----QDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGG 682
           L+      GH       + SL W+ +G  LAT   DG  R++        L    G   G
Sbjct: 223 LRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQHKG 279

Query: 683 RGARIVWVCDGRCLLVSGFD 702
               + W   G  +L +G D
Sbjct: 280 PIFALKWNRKGNYILSAGVD 299



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 38/122 (31%), Positives = 53/122 (43%), Gaps = 17/122 (13%)

Query: 550 LAWDPFDPHR--------LAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLR 601
           + W P  P          LA A  D+ +RLW +     E  + T    LT H E + S+ 
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDI-----ERGVCTH--TLTKHQEPVYSVA 461

Query: 602 FHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRV 661
           F P     LAS S+D  V IW+ Q+G      +G    IF + W+  G ++     DG V
Sbjct: 462 FSP-DGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 519

Query: 662 RV 663
            V
Sbjct: 520 CV 521



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 36/142 (25%), Positives = 64/142 (45%), Gaps = 13/142 (9%)

Query: 70  VAHLGC---------HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPG--QALPSAP 118
           V  LGC         H++ V  + + P    LLA+ S D T+K+W +        L +  
Sbjct: 345 VCRLGCDRPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHN 403

Query: 119 GVVLGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTELAAHGDLVQSAVWS 177
             +   +  P      +P S+ +L SA+  +TV++WD  +      L  H + V S  +S
Sbjct: 404 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFS 463

Query: 178 RDGALVGTACKDKQLRIFDPRT 199
            DG  + +   DK + I++ ++
Sbjct: 464 PDGKYLASGSFDKCVHIWNTQS 485



 Score = 34.7 bits (78), Expect = 0.42
 Identities = 48/211 (22%), Positives = 74/211 (35%), Gaps = 56/211 (26%)

Query: 80  VTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSD 139
           VT LD++  +  LLATGS D   ++W   G   +        LG    P+  L+++   +
Sbjct: 240 VTSLDWNT-NGTLLATGSYDGFARIWTEDGNLAS-------TLGQHKGPIFALKWNRKGN 291

Query: 140 GILVSAAGTTVKVWDA----AKQQ------------------------------------ 159
            IL +    T  +WDA    AKQQ                                    
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 351

Query: 160 -PLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRL 218
            P+     H + V +  W   G L+ +   D  L+I+  + +       QAH N     +
Sbjct: 352 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEV-CIHDLQAH-NKEIYTI 409

Query: 219 AWMGTWEHLVSTGFNQMR-----EREVKLWD 244
            W  T     +   N M      +  V+LWD
Sbjct: 410 KWSPTGPATSNPNSNIMLASASFDSTVRLWD 440



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 14/54 (25%), Positives = 27/54 (50%)

Query: 611 ASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
           AS S D+ + +  L         QGH +++ ++ W P G  LA+   D  ++++
Sbjct: 335 ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 34/132 (25%), Positives = 54/132 (40%), Gaps = 10/132 (7%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRL----PGPGQALPSAPGVVLGPEDLP--V 129
           H   V    ++P  D LLA+GS D T ++W L     G    L     +  G  D+P   
Sbjct: 180 HESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 238

Query: 130 EVLQFHPTSDGILVSAAGTT--VKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTAC 187
           +V      ++G L++        ++W        T L  H   + +  W+R G  + +A 
Sbjct: 239 DVTSLDWNTNGTLLATGSYDGFARIWTEDGNLAST-LGQHKGPIFALKWNRKGNYILSAG 297

Query: 188 KDKQLRIFDPRT 199
            DK   I+D  T
Sbjct: 298 VDKTTIIWDAHT 309



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 34/134 (25%), Positives = 56/134 (41%), Gaps = 11/134 (8%)

Query: 551 AWDPFDPHRLAVAGEDARIRLWRVP--AEGLEEVLTTPETVLTG-----HTEKICSLRFH 603
           AW+P     LA    D+  R+W +   + G    L     +  G       + + SL ++
Sbjct: 188 AWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWN 246

Query: 604 PLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRV 663
                +LA+ SYD   RIW  + G     L  H+  IF+L W+  G  + +   D    +
Sbjct: 247 T-NGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTII 304

Query: 664 YRPRSGPEPLQEGP 677
           +   +G E  Q+ P
Sbjct: 305 WDAHTG-EAKQQFP 317



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 31/145 (21%), Positives = 55/145 (37%), Gaps = 21/145 (14%)

Query: 114 LPSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWD-------AAKQQPLTELAA 166
           +PS+   VL   +  V +  ++P SD +   +  +T ++W+        + Q  L     
Sbjct: 169 IPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIR 228

Query: 167 HGDL-------VQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLA 219
            G         V S  W+ +G L+ T   D   RI+   T+     ST          L 
Sbjct: 229 EGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALK 285

Query: 220 WMGTWEHLVSTGFNQMREREVKLWD 244
           W     +++S G     ++   +WD
Sbjct: 286 WNRKGNYILSAGV----DKTTIIWD 306


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 41/131 (31%), Positives = 71/131 (54%), Gaps = 16/131 (12%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLA 606
           V  + WDP     LA   +D  +++W +     +EV       L  H ++I ++++ P  
Sbjct: 415 VNAIKWDP-SGMLLASCSDDMTLKIWSMK----QEVCIHD---LQAHNKEIYTIKWSPTG 466

Query: 607 -------ANV-LASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKD 658
                  +N+ LAS+S+D TVR+WD++ G     L  HQ+ ++S+A+SPDG+ LA+   D
Sbjct: 467 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 526

Query: 659 GRVRVYRPRSG 669
             V ++  +SG
Sbjct: 527 KCVHIWNTQSG 537



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 41/140 (29%), Positives = 65/140 (46%), Gaps = 18/140 (12%)

Query: 577 EGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDL----QAGADRLK 632
           +G  E+ ++  TVL GH  ++    ++P++ ++LAS S D T RIW+L      G+ +L 
Sbjct: 215 DGEVEIPSSKATVLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLV 273

Query: 633 LQ------GH----QDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGG 682
           L+      GH       + SL W+ +G  LAT   DG  R++        L    G   G
Sbjct: 274 LRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQHKG 330

Query: 683 RGARIVWVCDGRCLLVSGFD 702
               + W   G  +L +G D
Sbjct: 331 PIFALKWNRKGNYILSAGVD 350



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 38/122 (31%), Positives = 53/122 (43%), Gaps = 17/122 (13%)

Query: 550 LAWDPFDPHR--------LAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLR 601
           + W P  P          LA A  D+ +RLW +     E  + T    LT H E + S+ 
Sbjct: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDI-----ERGVCTH--TLTKHQEPVYSVA 512

Query: 602 FHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRV 661
           F P     LAS S+D  V IW+ Q+G      +G    IF + W+  G ++     DG V
Sbjct: 513 FSP-DGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 570

Query: 662 RV 663
            V
Sbjct: 571 CV 572



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 36/142 (25%), Positives = 64/142 (45%), Gaps = 13/142 (9%)

Query: 70  VAHLGC---------HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPG--QALPSAP 118
           V  LGC         H++ V  + + P    LLA+ S D T+K+W +        L +  
Sbjct: 396 VCRLGCDRPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHN 454

Query: 119 GVVLGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTELAAHGDLVQSAVWS 177
             +   +  P      +P S+ +L SA+  +TV++WD  +      L  H + V S  +S
Sbjct: 455 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFS 514

Query: 178 RDGALVGTACKDKQLRIFDPRT 199
            DG  + +   DK + I++ ++
Sbjct: 515 PDGKYLASGSFDKCVHIWNTQS 536



 Score = 34.7 bits (78), Expect = 0.42
 Identities = 48/211 (22%), Positives = 74/211 (35%), Gaps = 56/211 (26%)

Query: 80  VTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSD 139
           VT LD++  +  LLATGS D   ++W   G   +        LG    P+  L+++   +
Sbjct: 291 VTSLDWNT-NGTLLATGSYDGFARIWTEDGNLAS-------TLGQHKGPIFALKWNRKGN 342

Query: 140 GILVSAAGTTVKVWDA----AKQQ------------------------------------ 159
            IL +    T  +WDA    AKQQ                                    
Sbjct: 343 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 402

Query: 160 -PLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRL 218
            P+     H + V +  W   G L+ +   D  L+I+  + +       QAH N     +
Sbjct: 403 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEV-CIHDLQAH-NKEIYTI 460

Query: 219 AWMGTWEHLVSTGFNQMR-----EREVKLWD 244
            W  T     +   N M      +  V+LWD
Sbjct: 461 KWSPTGPATSNPNSNIMLASASFDSTVRLWD 491



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 14/54 (25%), Positives = 27/54 (50%)

Query: 611 ASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
           AS S D+ + +  L         QGH +++ ++ W P G  LA+   D  ++++
Sbjct: 386 ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 34/132 (25%), Positives = 54/132 (40%), Gaps = 10/132 (7%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRL----PGPGQALPSAPGVVLGPEDLP--V 129
           H   V    ++P  D LLA+GS D T ++W L     G    L     +  G  D+P   
Sbjct: 231 HESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 289

Query: 130 EVLQFHPTSDGILVSAAGTT--VKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTAC 187
           +V      ++G L++        ++W        T L  H   + +  W+R G  + +A 
Sbjct: 290 DVTSLDWNTNGTLLATGSYDGFARIWTEDGNLAST-LGQHKGPIFALKWNRKGNYILSAG 348

Query: 188 KDKQLRIFDPRT 199
            DK   I+D  T
Sbjct: 349 VDKTTIIWDAHT 360



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 34/134 (25%), Positives = 56/134 (41%), Gaps = 11/134 (8%)

Query: 551 AWDPFDPHRLAVAGEDARIRLWRVP--AEGLEEVLTTPETVLTG-----HTEKICSLRFH 603
           AW+P     LA    D+  R+W +   + G    L     +  G       + + SL ++
Sbjct: 239 AWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWN 297

Query: 604 PLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRV 663
                +LA+ SYD   RIW  + G     L  H+  IF+L W+  G  + +   D    +
Sbjct: 298 T-NGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTII 355

Query: 664 YRPRSGPEPLQEGP 677
           +   +G E  Q+ P
Sbjct: 356 WDAHTG-EAKQQFP 368



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 31/145 (21%), Positives = 55/145 (37%), Gaps = 21/145 (14%)

Query: 114 LPSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWD-------AAKQQPLTELAA 166
           +PS+   VL   +  V +  ++P SD +   +  +T ++W+        + Q  L     
Sbjct: 220 IPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIR 279

Query: 167 HGDL-------VQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLA 219
            G         V S  W+ +G L+ T   D   RI+   T+     ST          L 
Sbjct: 280 EGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALK 336

Query: 220 WMGTWEHLVSTGFNQMREREVKLWD 244
           W     +++S G     ++   +WD
Sbjct: 337 WNRKGNYILSAGV----DKTTIIWD 357


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 41/131 (31%), Positives = 71/131 (54%), Gaps = 16/131 (12%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLA 606
           V  + WDP     LA   +D  +++W +     +EV       L  H ++I ++++ P  
Sbjct: 415 VNAIKWDP-SGMLLASCSDDMTLKIWSMK----QEVCIHD---LQAHNKEIYTIKWSPTG 466

Query: 607 -------ANV-LASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKD 658
                  +N+ LAS+S+D TVR+WD++ G     L  HQ+ ++S+A+SPDG+ LA+   D
Sbjct: 467 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 526

Query: 659 GRVRVYRPRSG 669
             V ++  +SG
Sbjct: 527 KCVHIWNTQSG 537



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 41/140 (29%), Positives = 65/140 (46%), Gaps = 18/140 (12%)

Query: 577 EGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDL----QAGADRLK 632
           +G  E+ ++  TVL GH  ++    ++P++ ++LAS S D T RIW+L      G+ +L 
Sbjct: 215 DGEVEIPSSKATVLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLV 273

Query: 633 LQ------GH----QDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGG 682
           L+      GH       + SL W+ +G  LAT   DG  R++        L    G   G
Sbjct: 274 LRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQHKG 330

Query: 683 RGARIVWVCDGRCLLVSGFD 702
               + W   G  +L +G D
Sbjct: 331 PIFALKWNRKGNYILSAGVD 350



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 38/122 (31%), Positives = 53/122 (43%), Gaps = 17/122 (13%)

Query: 550 LAWDPFDPHR--------LAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLR 601
           + W P  P          LA A  D+ +RLW +     E  + T    LT H E + S+ 
Sbjct: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDI-----ERGVCTH--TLTKHQEPVYSVA 512

Query: 602 FHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRV 661
           F P     LAS S+D  V IW+ Q+G      +G    IF + W+  G ++     DG V
Sbjct: 513 FSP-DGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 570

Query: 662 RV 663
            V
Sbjct: 571 CV 572



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 36/142 (25%), Positives = 64/142 (45%), Gaps = 13/142 (9%)

Query: 70  VAHLGC---------HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPG--QALPSAP 118
           V  LGC         H++ V  + + P    LLA+ S D T+K+W +        L +  
Sbjct: 396 VCRLGCDRPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHN 454

Query: 119 GVVLGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTELAAHGDLVQSAVWS 177
             +   +  P      +P S+ +L SA+  +TV++WD  +      L  H + V S  +S
Sbjct: 455 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFS 514

Query: 178 RDGALVGTACKDKQLRIFDPRT 199
            DG  + +   DK + I++ ++
Sbjct: 515 PDGKYLASGSFDKCVHIWNTQS 536



 Score = 34.7 bits (78), Expect = 0.42
 Identities = 48/211 (22%), Positives = 74/211 (35%), Gaps = 56/211 (26%)

Query: 80  VTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSD 139
           VT LD++  +  LLATGS D   ++W   G   +        LG    P+  L+++   +
Sbjct: 291 VTSLDWNT-NGTLLATGSYDGFARIWTEDGNLAS-------TLGQHKGPIFALKWNRKGN 342

Query: 140 GILVSAAGTTVKVWDA----AKQQ------------------------------------ 159
            IL +    T  +WDA    AKQQ                                    
Sbjct: 343 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 402

Query: 160 -PLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRL 218
            P+     H + V +  W   G L+ +   D  L+I+  + +       QAH N     +
Sbjct: 403 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEV-CIHDLQAH-NKEIYTI 460

Query: 219 AWMGTWEHLVSTGFNQMR-----EREVKLWD 244
            W  T     +   N M      +  V+LWD
Sbjct: 461 KWSPTGPATSNPNSNIMLASASFDSTVRLWD 491



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 14/54 (25%), Positives = 27/54 (50%)

Query: 611 ASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
           AS S D+ + +  L         QGH +++ ++ W P G  LA+   D  ++++
Sbjct: 386 ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 34/132 (25%), Positives = 54/132 (40%), Gaps = 10/132 (7%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRL----PGPGQALPSAPGVVLGPEDLP--V 129
           H   V    ++P  D LLA+GS D T ++W L     G    L     +  G  D+P   
Sbjct: 231 HESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 289

Query: 130 EVLQFHPTSDGILVSAAGTT--VKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTAC 187
           +V      ++G L++        ++W        T L  H   + +  W+R G  + +A 
Sbjct: 290 DVTSLDWNTNGTLLATGSYDGFARIWTEDGNLAST-LGQHKGPIFALKWNRKGNYILSAG 348

Query: 188 KDKQLRIFDPRT 199
            DK   I+D  T
Sbjct: 349 VDKTTIIWDAHT 360



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 34/134 (25%), Positives = 56/134 (41%), Gaps = 11/134 (8%)

Query: 551 AWDPFDPHRLAVAGEDARIRLWRVP--AEGLEEVLTTPETVLTG-----HTEKICSLRFH 603
           AW+P     LA    D+  R+W +   + G    L     +  G       + + SL ++
Sbjct: 239 AWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWN 297

Query: 604 PLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRV 663
                +LA+ SYD   RIW  + G     L  H+  IF+L W+  G  + +   D    +
Sbjct: 298 T-NGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTII 355

Query: 664 YRPRSGPEPLQEGP 677
           +   +G E  Q+ P
Sbjct: 356 WDAHTG-EAKQQFP 368



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 31/145 (21%), Positives = 55/145 (37%), Gaps = 21/145 (14%)

Query: 114 LPSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWD-------AAKQQPLTELAA 166
           +PS+   VL   +  V +  ++P SD +   +  +T ++W+        + Q  L     
Sbjct: 220 IPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIR 279

Query: 167 HGDL-------VQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLA 219
            G         V S  W+ +G L+ T   D   RI+   T+     ST          L 
Sbjct: 280 EGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALK 336

Query: 220 WMGTWEHLVSTGFNQMREREVKLWD 244
           W     +++S G     ++   +WD
Sbjct: 337 WNRKGNYILSAGV----DKTTIIWD 357


>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
          Length = 193

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 48/138 (34%), Positives = 71/138 (51%), Gaps = 11/138 (7%)

Query: 60  LQGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPG 119
           L    EDK+ +  +  H  L+  + FSP D  ++A+ S D+++KLW     G+ L S  G
Sbjct: 63  LWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD-GRTGKYLASLRG 120

Query: 120 VVLGPEDLPVEVLQFHPTSDG-ILVSAAG-TTVKVWDAAKQQPLTELAAHGDLVQSAVWS 177
            V         V Q   ++D  +LVS +  +T+KVWD   Q+   +L  H D V +  WS
Sbjct: 121 HVAA-------VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWS 173

Query: 178 RDGALVGTACKDKQLRIF 195
            DG  V +  KDK LRI+
Sbjct: 174 PDGQRVASGGKDKCLRIW 191



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 43/145 (29%), Positives = 71/145 (48%), Gaps = 37/145 (25%)

Query: 557 PHRLAVAGEDARIRLWRVPAEG-------------LEEVLTTPETVLT------------ 591
           P RL    +D  + LW  PAE              + +VL +P++ +             
Sbjct: 49  PERLVSGSDDFTLFLWS-PAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW 107

Query: 592 -GHTEK-ICSLRFHPLA---------ANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQI 640
            G T K + SLR H  A         + +L S S D T+++WD++A    + L GH D++
Sbjct: 108 DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEV 167

Query: 641 FSLAWSPDGQQLATVCKDGRVRVYR 665
           +++ WSPDGQ++A+  KD  +R++R
Sbjct: 168 YAVDWSPDGQRVASGGKDKCLRIWR 192



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 30/111 (27%), Positives = 50/111 (45%), Gaps = 5/111 (4%)

Query: 93  LATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKV 152
           L +GS D T+ LW      + L      + G + L  +VL F P S  +  ++   ++K+
Sbjct: 52  LVSGSDDFTLFLWSPAEDKKPLTR----MTGHQALINQVL-FSPDSRIVASASFDKSIKL 106

Query: 153 WDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRA 203
           WD    + L  L  H   V    WS D  L+ +   D  L+++D + +  A
Sbjct: 107 WDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLA 157



 Score = 33.9 bits (76), Expect = 0.72
 Identities = 32/110 (29%), Positives = 54/110 (49%), Gaps = 11/110 (10%)

Query: 610 LASSSYDLTVRIWDLQAGADRL-KLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRS 668
           L S S D T+ +W        L ++ GHQ  I  + +SPD + +A+   D  ++++  R+
Sbjct: 52  LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 111

Query: 669 GPEPLQEGPGPKGGRGA--RIVWVCDGRCLLVSGFDSQSERQLLLYEAEA 716
           G    +     +G   A  +I W  D R LLVSG    S+  L +++ +A
Sbjct: 112 G----KYLASLRGHVAAVYQIAWSADSR-LLVSG---SSDSTLKVWDVKA 153


>gi|4757988 WD repeat domain 39 [Homo sapiens]
          Length = 339

 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 51/164 (31%), Positives = 82/164 (50%), Gaps = 22/164 (13%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLA 606
           V  +AW P   + LA    D  + +W V  E   E ++    VL  HT+ +  + +HP +
Sbjct: 108 VKSVAWAP-SGNLLATCSRDKSVWVWEVDEEDEYECVS----VLNSHTQDVKHVVWHP-S 161

Query: 607 ANVLASSSYDLTVRIWDLQAG--ADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
             +LAS+SYD TV+++  +         L+GH+  ++SLA+ P GQ+LA+   D  VR++
Sbjct: 162 QELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221

Query: 665 RPRSGPEPLQEGPGPKGG---RGARIVWVCDGRCLLVSGFDSQS 705
           R        Q  PG + G    G+   W C      +SGF S++
Sbjct: 222 R--------QYLPGNEQGVACSGSDPSWKC---ICTLSGFHSRT 254



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 43/120 (35%), Positives = 64/120 (53%), Gaps = 14/120 (11%)

Query: 550 LAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLT-GHTEKICSLRFHPLAAN 608
           LAW+P     LA  G D RIR+W     G E      ++VL+ GH   +  + + P   N
Sbjct: 22  LAWNPAGT-LLASCGGDRRIRIW-----GTEGDSWICKSVLSEGHQRTVRKVAWSP-CGN 74

Query: 609 VLASSSYDLTVRIWDLQAGADRLK----LQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
            LAS+S+D T  IW  +   D  +    L+GH++++ S+AW+P G  LAT  +D  V V+
Sbjct: 75  YLASASFDATTCIW--KKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVW 132



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 44/144 (30%), Positives = 59/144 (40%), Gaps = 23/144 (15%)

Query: 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLA 606
           V  + W P     LA A  D  ++L+R   +      T     L GH   + SL F P +
Sbjct: 153 VKHVVWHP-SQELLASASYDDTVKLYREEEDDWVCCAT-----LEGHESTVWSLAFDP-S 205

Query: 607 ANVLASSSYDLTVRIWDLQ----------AGADR-----LKLQG-HQDQIFSLAWSPDGQ 650
              LAS S D TVRIW             +G+D        L G H   I+ +AW     
Sbjct: 206 GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTG 265

Query: 651 QLATVCKDGRVRVYRPRSGPEPLQ 674
            LAT C D  +RV++     +P Q
Sbjct: 266 ALATACGDDAIRVFQEDPNSDPQQ 289



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 29/145 (20%), Positives = 63/145 (43%), Gaps = 6/145 (4%)

Query: 92  LLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVK 151
           LLA+   DR +++W   G      S   V+       V  + + P  + +  ++   T  
Sbjct: 30  LLASCGGDRRIRIWGTEGDSWICKS---VLSEGHQRTVRKVAWSPCGNYLASASFDATTC 86

Query: 152 VWDAAKQ--QPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQA 209
           +W   +   + +T L  H + V+S  W+  G L+ T  +DK + +++   +      +  
Sbjct: 87  IWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVL 146

Query: 210 HENSRD-SRLAWMGTWEHLVSTGFN 233
           + +++D   + W  + E L S  ++
Sbjct: 147 NSHTQDVKHVVWHPSQELLASASYD 171



 Score = 37.0 bits (84), Expect = 0.085
 Identities = 28/104 (26%), Positives = 43/104 (41%), Gaps = 19/104 (18%)

Query: 565 EDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDL 624
           +D+ + L RVPA                H +  C       A  +LAS   D  +RIW  
Sbjct: 2   KDSLVLLGRVPA----------------HPDSRCWFLAWNPAGTLLASCGGDRRIRIWGT 45

Query: 625 QAGADRLKL---QGHQDQIFSLAWSPDGQQLATVCKDGRVRVYR 665
           +  +   K    +GHQ  +  +AWSP G  LA+   D    +++
Sbjct: 46  EGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWK 89



 Score = 34.3 bits (77), Expect = 0.55
 Identities = 42/174 (24%), Positives = 69/174 (39%), Gaps = 28/174 (16%)

Query: 70  VAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPV 129
           V+ L  H+  V  + + P  + LLA+ S D TVKL+R         +     L   +  V
Sbjct: 143 VSVLNSHTQDVKHVVWHPSQE-LLASASYDDTVKLYREEEDDWVCCAT----LEGHESTV 197

Query: 130 EVLQFHPTSDGILVSAAGTTVKVW----------------DAAKQQPLTELAAHGDLVQS 173
             L F P+   +   +   TV++W                D + +   T    H   +  
Sbjct: 198 WSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYD 257

Query: 174 AVWSRDGALVGTACKDKQLRIF--DPRTKP-RASQSTQAHENSRDSR----LAW 220
             W +    + TAC D  +R+F  DP + P + + S  AH +   S+    +AW
Sbjct: 258 IAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAW 311



 Score = 33.9 bits (76), Expect = 0.72
 Identities = 35/147 (23%), Positives = 58/147 (39%), Gaps = 20/147 (13%)

Query: 545 AAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPET--------VLTG-HTE 595
           + V  LA+DP    RLA   +D  +R+WR    G E+ +    +         L+G H+ 
Sbjct: 195 STVWSLAFDP-SGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSR 253

Query: 596 KICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKL---------QGHQDQIFSLAWS 646
            I  + +  L    LA++  D  +R++     +D  +          Q H   +  +AW+
Sbjct: 254 TIYDIAWCQLTG-ALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWN 312

Query: 647 PDGQQLATVCKDGRVRVYRPRSGPEPL 673
           P    L   C D     +     PE L
Sbjct: 313 PKEPGLLASCSDDGEVAFWKYQRPEGL 339


>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 45/170 (26%), Positives = 77/170 (45%), Gaps = 15/170 (8%)

Query: 529 KPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPET 588
           K G++ D       + A V D+AW            +D ++ +W    +      + P  
Sbjct: 211 KEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIW----DTRSNTTSKPSH 266

Query: 589 VLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRL-KLQGHQDQIFSLAWSP 647
           ++  HT ++  L F+P +  +LA+ S D TV +WDL+    +L   + H+D+IF + WSP
Sbjct: 267 LVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSP 326

Query: 648 DGQQ-LATVCKDGRVRVY-----RPRSGPEPLQEGPGP----KGGRGARI 687
             +  LA+   D R+ V+           E  ++GP       GG  A+I
Sbjct: 327 HNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKI 376



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 31/85 (36%), Positives = 44/85 (51%), Gaps = 10/85 (11%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFH 135
           H+  V  L F+P+ +F+LATGSAD+TV LW L      L +        E    E+ Q H
Sbjct: 271 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTF-------ESHKDEIFQVH 323

Query: 136 --PTSDGILVSA-AGTTVKVWDAAK 157
             P ++ IL S+     + VWD +K
Sbjct: 324 WSPHNETILASSGTDRRLNVWDLSK 348



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 35/152 (23%), Positives = 65/152 (42%), Gaps = 27/152 (17%)

Query: 529 KPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPET 588
           KP  L D       + A V  L+++P+    LA    D  + LW +    L+  L T E+
Sbjct: 263 KPSHLVDA------HTAEVNCLSFNPYSEFILATGSADKTVALWDL--RNLKLKLHTFES 314

Query: 589 VLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQ-------------- 634
               H ++I  + + P    +LASS  D  + +WDL    +    +              
Sbjct: 315 ----HKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHG 370

Query: 635 GHQDQIFSLAWSP-DGQQLATVCKDGRVRVYR 665
           GH  +I   +W+P +   + +V +D  +++++
Sbjct: 371 GHTAKISDFSWNPNEPWVICSVSEDNIMQIWQ 402



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 28/123 (22%), Positives = 56/123 (45%), Gaps = 4/123 (3%)

Query: 550 LAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANV 609
           L+W+      L  A +D  + LW + A   E  +   + + TGH+  +  + +H L  ++
Sbjct: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241

Query: 610 LASSSYDLTVRIWDLQAGADRLK---LQGHQDQIFSLAWSPDGQ-QLATVCKDGRVRVYR 665
             S + D  + IWD ++         +  H  ++  L+++P  +  LAT   D  V ++ 
Sbjct: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 301

Query: 666 PRS 668
            R+
Sbjct: 302 LRN 304



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 23/80 (28%), Positives = 36/80 (45%), Gaps = 7/80 (8%)

Query: 552 WDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPET-------VLTGHTEKICSLRFHP 604
           W P +   LA +G D R+ +W +   G E+     E        +  GHT KI    ++P
Sbjct: 324 WSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNP 383

Query: 605 LAANVLASSSYDLTVRIWDL 624
               V+ S S D  ++IW +
Sbjct: 384 NEPWVICSVSEDNIMQIWQM 403



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 31/126 (24%), Positives = 57/126 (45%), Gaps = 11/126 (8%)

Query: 554 PFDPHRLAVAGEDARIRLW---RVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVL 610
           P +PH +A     + + ++   + PA+        P+  L GH ++   L ++   +  L
Sbjct: 133 PQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHL 192

Query: 611 ASSSYDLTVRIWDLQAGADRLKL-------QGHQDQIFSLAWSPDGQQL-ATVCKDGRVR 662
            S+S D TV +WD+ AG    K+        GH   +  +AW    + L  +V  D ++ 
Sbjct: 193 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 252

Query: 663 VYRPRS 668
           ++  RS
Sbjct: 253 IWDTRS 258



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 17/60 (28%), Positives = 29/60 (48%), Gaps = 5/60 (8%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFH 135
           H D +  + +SP ++ +LA+   DR + +W L   G+   +        ED P E+L  H
Sbjct: 315 HKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDA-----EDGPPELLFIH 369



 Score = 30.4 bits (67), Expect = 7.9
 Identities = 38/185 (20%), Positives = 78/185 (42%), Gaps = 21/185 (11%)

Query: 593 HTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADR----------LKLQGHQDQIFS 642
           H  ++   R+ P   +++A+ +    V ++D      +          L+L+GHQ + + 
Sbjct: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 181

Query: 643 LAWSPD-GQQLATVCKDGRVRVYRPRSGPEP--LQEGPGPKGGRGA---RIVWVCDGRCL 696
           L+W+ +    L +   D  V ++   +GP+   + +      G  A    + W      L
Sbjct: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241

Query: 697 LVSGFDSQSERQLLLYEAEA-LAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRV 755
             S  D Q   +L++++  +     P  ++    A    L S++P +  +L TG  D  V
Sbjct: 242 FGSVADDQ---KLMIWDTRSNTTSKPSHLVDAHTAEVNCL-SFNPYSEFILATGSADKTV 297

Query: 756 FLYEL 760
            L++L
Sbjct: 298 ALWDL 302


>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
           sapiens]
          Length = 421

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 57/184 (30%), Positives = 87/184 (47%), Gaps = 24/184 (13%)

Query: 477 QGTVLHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVAVLELRKPGRLPDT 536
           Q  +LH   ++TN   L L     SDG   NK R  +  +  G  V  L          +
Sbjct: 68  QNFLLHGTKNVTNSSSLRLPRQN-SDGGQKNKPREHI--IDCGDIVWSLAF-------GS 117

Query: 537 ALPTLQNGAAVTDLAWDPF----DPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTG 592
           ++P  Q+     ++ W  F    D   LA    + RI++W V    L  +L      L  
Sbjct: 118 SVPEKQSRCV--NIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKL--LLN-----LVD 168

Query: 593 HTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLK-LQGHQDQIFSLAWSPDGQQ 651
           HTE +  L F P  + +L S+S D T+R+WDL+   + +K L+GHQ+ ++S A+SPD   
Sbjct: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228

Query: 652 LATV 655
           L +V
Sbjct: 229 LCSV 232



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 37/122 (30%), Positives = 59/122 (48%), Gaps = 5/122 (4%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFH 135
           H+++V DL F+P    +L + S D+T+++W L   G  +      VL      V    F 
Sbjct: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMK-----VLRGHQNWVYSCAFS 223

Query: 136 PTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIF 195
           P S  +    A   V +W+  K   + +L  H   V +  +S DGAL+ TA  D ++ I+
Sbjct: 224 PDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW 283

Query: 196 DP 197
           DP
Sbjct: 284 DP 285



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 18/64 (28%), Positives = 36/64 (56%), Gaps = 1/64 (1%)

Query: 150 VKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALV-GTACKDKQLRIFDPRTKPRASQSTQ 208
           +K+WD    + L  L  H ++V+   ++ DG+L+  +A +DK LR++D +      +  +
Sbjct: 152 IKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLR 211

Query: 209 AHEN 212
            H+N
Sbjct: 212 GHQN 215


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 50/173 (28%), Positives = 79/173 (45%), Gaps = 17/173 (9%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVV--LGPEDLPVEVLQ 133
           H D+VT + FSP  + LLA+ S DRTV+LW        +P   G          PV  + 
Sbjct: 59  HKDVVTSVQFSPHGN-LLASASRDRTVRLW--------IPDKRGKFSEFKAHTAPVRSVD 109

Query: 134 FHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLR 193
           F      +  ++   ++KVW   +Q+ L  L  H   V+ A +S DG L+ +  +DK ++
Sbjct: 110 FSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIK 169

Query: 194 IFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLWDTR 246
           I+D   K   +  + +   +        GT   + S G +Q     VK+WD R
Sbjct: 170 IWDTTNKQCVNNFSDSVGFANFVDFNPSGTC--IASAGSDQ----TVKVWDVR 216



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 37/120 (30%), Positives = 57/120 (47%), Gaps = 9/120 (7%)

Query: 545 AAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHP 604
           AA+T L   P +  +LA A  D  + LW                   GH + + S++F P
Sbjct: 19  AAITSLDLSP-NGKQLATASWDTFLMLWNFKPHARAYRYV-------GHKDVVTSVQFSP 70

Query: 605 LAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
              N+LAS+S D TVR+W         + + H   + S+ +S DGQ LAT  +D  ++V+
Sbjct: 71  -HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 26/80 (32%), Positives = 42/80 (52%), Gaps = 1/80 (1%)

Query: 587 ETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWS 646
           E    GH   I SL   P     LA++S+D  + +W+ +  A   +  GH+D + S+ +S
Sbjct: 11  ERYFKGHKAAITSLDLSPNGKQ-LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69

Query: 647 PDGQQLATVCKDGRVRVYRP 666
           P G  LA+  +D  VR++ P
Sbjct: 70  PHGNLLASASRDRTVRLWIP 89



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 32/121 (26%), Positives = 48/121 (39%), Gaps = 7/121 (5%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFH 135
           H+  V    FSP D  L+ + S D+T+K+W           +  V           + F+
Sbjct: 143 HTHWVRCAKFSP-DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA------NFVDFN 195

Query: 136 PTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIF 195
           P+   I  + +  TVKVWD    + L     H   V    +   G  + TA  D  L+I 
Sbjct: 196 PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKIL 255

Query: 196 D 196
           D
Sbjct: 256 D 256



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 27/112 (24%), Positives = 48/112 (42%), Gaps = 10/112 (8%)

Query: 555 FDPHR--LAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLAS 612
           F PH   LA A  D  +RLW     G         +    HT  + S+ F       LA+
Sbjct: 68  FSPHGNLLASASRDRTVRLWIPDKRG-------KFSEFKAHTAPVRSVDFSA-DGQFLAT 119

Query: 613 SSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
           +S D ++++W +        L  H   +    +SPDG+ + +  +D  ++++
Sbjct: 120 ASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 23/110 (20%), Positives = 45/110 (40%), Gaps = 12/110 (10%)

Query: 556 DPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPL--AANVLASS 613
           D   +    ED  I++W           TT +  +   ++ +    F     +   +AS+
Sbjct: 155 DGRLIVSCSEDKTIKIWD----------TTNKQCVNNFSDSVGFANFVDFNPSGTCIASA 204

Query: 614 SYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRV 663
             D TV++WD++        Q H   +  +++ P G  L T   DG +++
Sbjct: 205 GSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKI 254



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 29/128 (22%), Positives = 59/128 (46%), Gaps = 15/128 (11%)

Query: 75  CHSDLVTDLDFSPFDDF-----LLATGSADRTVKLW--RLPGPGQALPSAPGVVLGPEDL 127
           C ++    + F+ F DF      +A+  +D+TVK+W  R+    Q      G        
Sbjct: 178 CVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG-------- 229

Query: 128 PVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTAC 187
            V  + FHP+ + ++ +++  T+K+ D  + + +  L  H   V +  +S+ G L  +  
Sbjct: 230 GVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGG 289

Query: 188 KDKQLRIF 195
            D Q+ ++
Sbjct: 290 ADTQVLLW 297



 Score = 31.2 bits (69), Expect = 4.7
 Identities = 16/74 (21%), Positives = 34/74 (45%)

Query: 132 LQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQ 191
           L   P    +  ++  T + +W+            H D+V S  +S  G L+ +A +D+ 
Sbjct: 24  LDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRT 83

Query: 192 LRIFDPRTKPRASQ 205
           +R++ P  + + S+
Sbjct: 84  VRLWIPDKRGKFSE 97


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 40/127 (31%), Positives = 66/127 (51%), Gaps = 11/127 (8%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPG--VVLGPEDLPVEVLQ 133
           H D VT ++FSP    LLA+GS D+TV++W        +P+  G   V       V  + 
Sbjct: 22  HKDAVTCVNFSP-SGHLLASGSRDKTVRIW--------VPNVKGESTVFRAHTATVRSVH 72

Query: 134 FHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLR 193
           F       + ++   TVKVW   +Q+ L  L+ H + V+ A +S DG L+ +A  DK ++
Sbjct: 73  FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVK 132

Query: 194 IFDPRTK 200
           ++D  ++
Sbjct: 133 LWDKSSR 139



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 62/239 (25%), Positives = 92/239 (38%), Gaps = 31/239 (12%)

Query: 73  LGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPG--QALPSAPGVVLGPEDLPVE 130
           L  H + V    FSP D  L+ + S D+TVKLW         +     G V         
Sbjct: 103 LSQHINWVRCAKFSP-DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT-------- 153

Query: 131 VLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDK 190
            + FHP+   I  +    TVKVWD    + L     H   V    +   G  + TA  D 
Sbjct: 154 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 213

Query: 191 QLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLWDTRF--- 247
            L+I D   + R   +   H+    + +A+  T E+  S G     + +V +W + F   
Sbjct: 214 TLKILD-LMEGRLLYTLHGHQGPA-TTVAFSRTGEYFASGG----SDEQVMVWKSNFDIV 267

Query: 248 -----FSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPVT 301
                        TL +S+G L     P+    V  G+G R +   +  PQ+P   P T
Sbjct: 268 DHGEVTKVPRPPATLASSMGNL-----PEVDFPVPPGRG-RSVESVQSQPQEPVSVPQT 320



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 24/74 (32%), Positives = 37/74 (50%), Gaps = 1/74 (1%)

Query: 591 TGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQ 650
           TGH + +  + F P + ++LAS S D TVRIW      +    + H   + S+ +  DGQ
Sbjct: 20  TGHKDAVTCVNFSP-SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQ 78

Query: 651 QLATVCKDGRVRVY 664
              T   D  V+V+
Sbjct: 79  SFVTASDDKTVKVW 92



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 51/223 (22%), Positives = 87/223 (39%), Gaps = 33/223 (14%)

Query: 546 AVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPL 605
           AVT + + P   H LA    D  +R+W    +G         TV   HT  + S+ F   
Sbjct: 25  AVTCVNFSP-SGHLLASGSRDKTVRIWVPNVKG-------ESTVFRAHTATVRSVHFCSD 76

Query: 606 AANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYR 665
             + + +S  D TV++W          L  H + +    +SPDG+ + +   D  V+++ 
Sbjct: 77  GQSFVTASD-DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 135

Query: 666 PRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDS-------QSERQLLLYEAEALA 718
             S            GG    + +   G C+  +G D+       ++ R L  Y+  +  
Sbjct: 136 KSS--RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHS-- 191

Query: 719 GGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELL 761
               AV GL   PS          G  L+T   D+ + + +L+
Sbjct: 192 ---AAVNGLSFHPS----------GNYLITASSDSTLKILDLM 221



 Score = 34.3 bits (77), Expect = 0.55
 Identities = 14/51 (27%), Positives = 28/51 (54%)

Query: 616 DLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRP 666
           D  + +W ++  +   +  GH+D +  + +SP G  LA+  +D  VR++ P
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVP 52


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 40/127 (31%), Positives = 66/127 (51%), Gaps = 11/127 (8%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPG--VVLGPEDLPVEVLQ 133
           H D VT ++FSP    LLA+GS D+TV++W        +P+  G   V       V  + 
Sbjct: 60  HKDAVTCVNFSP-SGHLLASGSRDKTVRIW--------VPNVKGESTVFRAHTATVRSVH 110

Query: 134 FHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLR 193
           F       + ++   TVKVW   +Q+ L  L+ H + V+ A +S DG L+ +A  DK ++
Sbjct: 111 FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVK 170

Query: 194 IFDPRTK 200
           ++D  ++
Sbjct: 171 LWDKSSR 177



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 47/177 (26%), Positives = 70/177 (39%), Gaps = 17/177 (9%)

Query: 73  LGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPG--QALPSAPGVVLGPEDLPVE 130
           L  H + V    FSP D  L+ + S D+TVKLW         +     G V         
Sbjct: 141 LSQHINWVRCAKFSP-DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT-------- 191

Query: 131 VLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDK 190
            + FHP+   I  +    TVKVWD    + L     H   V    +   G  + TA  D 
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251

Query: 191 QLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLWDTRF 247
            L+I D   + R   +   H+    + +A+  T E+  S G     + +V +W + F
Sbjct: 252 TLKILD-LMEGRLLYTLHGHQGPA-TTVAFSRTGEYFASGG----SDEQVMVWKSNF 302



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 33/117 (28%), Positives = 53/117 (45%), Gaps = 8/117 (6%)

Query: 555 FDPHRLAVAGEDARIRLWRVPAEGLEEVLTT----PETV---LTGHTEKICSLRFHPLAA 607
           F  HR AV   D  I   ++ +  ++  L      P++     TGH + +  + F P + 
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP-SG 73

Query: 608 NVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
           ++LAS S D TVRIW      +    + H   + S+ +  DGQ   T   D  V+V+
Sbjct: 74  HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 51/223 (22%), Positives = 87/223 (39%), Gaps = 33/223 (14%)

Query: 546 AVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPL 605
           AVT + + P   H LA    D  +R+W    +G         TV   HT  + S+ F   
Sbjct: 63  AVTCVNFSP-SGHLLASGSRDKTVRIWVPNVKG-------ESTVFRAHTATVRSVHFCSD 114

Query: 606 AANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYR 665
             + + +S  D TV++W          L  H + +    +SPDG+ + +   D  V+++ 
Sbjct: 115 GQSFVTASD-DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173

Query: 666 PRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDS-------QSERQLLLYEAEALA 718
             S            GG    + +   G C+  +G D+       ++ R L  Y+  +  
Sbjct: 174 KSS--RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHS-- 229

Query: 719 GGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELL 761
               AV GL   PS          G  L+T   D+ + + +L+
Sbjct: 230 ---AAVNGLSFHPS----------GNYLITASSDSTLKILDLM 259



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 21/75 (28%), Positives = 39/75 (52%), Gaps = 1/75 (1%)

Query: 592 GHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQ 651
           GH + +  + F  +    LAS S D  + +W ++  +   +  GH+D +  + +SP G  
Sbjct: 17  GHRDAVTCVDFS-INTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75

Query: 652 LATVCKDGRVRVYRP 666
           LA+  +D  VR++ P
Sbjct: 76  LASGSRDKTVRIWVP 90


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 40/127 (31%), Positives = 66/127 (51%), Gaps = 11/127 (8%)

Query: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPG--VVLGPEDLPVEVLQ 133
           H D VT ++FSP    LLA+GS D+TV++W        +P+  G   V       V  + 
Sbjct: 60  HKDAVTCVNFSP-SGHLLASGSRDKTVRIW--------VPNVKGESTVFRAHTATVRSVH 110

Query: 134 FHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLR 193
           F       + ++   TVKVW   +Q+ L  L+ H + V+ A +S DG L+ +A  DK ++
Sbjct: 111 FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVK 170

Query: 194 IFDPRTK 200
           ++D  ++
Sbjct: 171 LWDKSSR 177



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 62/239 (25%), Positives = 92/239 (38%), Gaps = 31/239 (12%)

Query: 73  LGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPG--QALPSAPGVVLGPEDLPVE 130
           L  H + V    FSP D  L+ + S D+TVKLW         +     G V         
Sbjct: 141 LSQHINWVRCAKFSP-DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT-------- 191

Query: 131 VLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDK 190
            + FHP+   I  +    TVKVWD    + L     H   V    +   G  + TA  D 
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251

Query: 191 QLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLWDTRF--- 247
            L+I D   + R   +   H+    + +A+  T E+  S G     + +V +W + F   
Sbjct: 252 TLKILD-LMEGRLLYTLHGHQGPA-TTVAFSRTGEYFASGG----SDEQVMVWKSNFDIV 305

Query: 248 -----FSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPVT 301
                        TL +S+G L     P+    V  G+G R +   +  PQ+P   P T
Sbjct: 306 DHGEVTKVPRPPATLASSMGNL-----PEVDFPVPPGRG-RSVESVQSQPQEPVSVPQT 358



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 33/117 (28%), Positives = 53/117 (45%), Gaps = 8/117 (6%)

Query: 555 FDPHRLAVAGEDARIRLWRVPAEGLEEVLTT----PETV---LTGHTEKICSLRFHPLAA 607
           F  HR AV   D  I   ++ +  ++  L      P++     TGH + +  + F P + 
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP-SG 73

Query: 608 NVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
           ++LAS S D TVRIW      +    + H   + S+ +  DGQ   T   D  V+V+
Sbjct: 74  HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 51/223 (22%), Positives = 87/223 (39%), Gaps = 33/223 (14%)

Query: 546 AVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPL 605
           AVT + + P   H LA    D  +R+W    +G         TV   HT  + S+ F   
Sbjct: 63  AVTCVNFSP-SGHLLASGSRDKTVRIWVPNVKG-------ESTVFRAHTATVRSVHFCSD 114

Query: 606 AANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYR 665
             + + +S  D TV++W          L  H + +    +SPDG+ + +   D  V+++ 
Sbjct: 115 GQSFVTASD-DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173

Query: 666 PRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDS-------QSERQLLLYEAEALA 718
             S            GG    + +   G C+  +G D+       ++ R L  Y+  +  
Sbjct: 174 KSS--RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHS-- 229

Query: 719 GGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELL 761
               AV GL   PS          G  L+T   D+ + + +L+
Sbjct: 230 ---AAVNGLSFHPS----------GNYLITASSDSTLKILDLM 259



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 21/75 (28%), Positives = 39/75 (52%), Gaps = 1/75 (1%)

Query: 592 GHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQ 651
           GH + +  + F  +    LAS S D  + +W ++  +   +  GH+D +  + +SP G  
Sbjct: 17  GHRDAVTCVDFS-INTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75

Query: 652 LATVCKDGRVRVYRP 666
           LA+  +D  VR++ P
Sbjct: 76  LASGSRDKTVRIWVP 90


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,978,456
Number of Sequences: 37866
Number of extensions: 2246882
Number of successful extensions: 13016
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 191
Number of HSP's successfully gapped in prelim test: 299
Number of HSP's that attempted gapping in prelim test: 10039
Number of HSP's gapped (non-prelim): 2627
length of query: 925
length of database: 18,247,518
effective HSP length: 112
effective length of query: 813
effective length of database: 14,006,526
effective search space: 11387305638
effective search space used: 11387305638
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.