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Search of human proteins with 110624794
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110624794 erythrocyte membrane protein band 4.1 like 4B
isoform 1 [Homo sapiens]
(518 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 1073 0.0
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 970 0.0
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 553 e-157
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 279 4e-75
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 273 3e-73
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 273 3e-73
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 273 3e-73
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 269 5e-72
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 265 1e-70
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 265 1e-70
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 261 1e-69
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 258 1e-68
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 258 1e-68
gi|117500790 FERM domain containing 3 [Homo sapiens] 231 1e-60
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 227 2e-59
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 211 1e-54
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 210 2e-54
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 201 1e-51
gi|34916000 FERM domain containing 7 [Homo sapiens] 193 4e-49
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 191 1e-48
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 190 3e-48
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 130 3e-30
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 126 4e-29
gi|38788243 myosin regulatory light chain interacting protein [H... 125 9e-29
gi|4506467 radixin [Homo sapiens] 116 4e-26
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 113 4e-25
gi|161702986 ezrin [Homo sapiens] 113 5e-25
gi|21614499 ezrin [Homo sapiens] 113 5e-25
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 112 6e-25
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 112 6e-25
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 1073 bits (2774), Expect = 0.0
Identities = 518/518 (100%), Positives = 518/518 (100%)
Query: 1 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60
MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP
Sbjct: 1 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60
Query: 61 AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120
AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL
Sbjct: 61 AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120
Query: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180
VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL
Sbjct: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180
Query: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240
FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME
Sbjct: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240
Query: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300
FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE
Sbjct: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300
Query: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360
GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE
Sbjct: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360
Query: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420
HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR
Sbjct: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420
Query: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVRPSFQDDRSHW 480
RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVRPSFQDDRSHW
Sbjct: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVRPSFQDDRSHW 480
Query: 481 KASASGDDSHFDYVHDQNQKNLGGMQSMMYRDKLMTAL 518
KASASGDDSHFDYVHDQNQKNLGGMQSMMYRDKLMTAL
Sbjct: 481 KASASGDDSHFDYVHDQNQKNLGGMQSMMYRDKLMTAL 518
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 970 bits (2507), Expect = 0.0
Identities = 469/469 (100%), Positives = 469/469 (100%)
Query: 1 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60
MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP
Sbjct: 1 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60
Query: 61 AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120
AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL
Sbjct: 61 AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120
Query: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180
VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL
Sbjct: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180
Query: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240
FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME
Sbjct: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240
Query: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300
FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE
Sbjct: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300
Query: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360
GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE
Sbjct: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360
Query: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420
HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR
Sbjct: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420
Query: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNV 469
RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNV
Sbjct: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNV 469
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 553 bits (1426), Expect = e-157
Identities = 289/474 (60%), Positives = 340/474 (71%), Gaps = 58/474 (12%)
Query: 1 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60
ML F RRT GRRSM+++A R A
Sbjct: 1 MLSFFRRTLGRRSMRKHAEKERLREAQR-------------------------------- 28
Query: 61 AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120
AA HI AAG +K+ + CRV LLDGT+VSVDLPK AKGQ+LFDQI+YHLDL
Sbjct: 29 ----------AATHIPAAGDSKSIITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDL 78
Query: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180
+E+DYFGL+F+DSAQVAHWLD K IKKQ+KIG Y LH RVK+YSSEPNNLREE TRYL
Sbjct: 79 IESDYFGLRFMDSAQVAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYL 138
Query: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240
FVLQL+ DILSGKL CP++TAV+LAA LQAELG+ +L EH+PELVSEFRF+P QTE ME
Sbjct: 139 FVLQLKQDILSGKLDCPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEME 198
Query: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300
IF++WKE RG++PAQAE +YLNKAKWLEMYGVDMHVV+ RDG +YSLGLTPTG+L+FE
Sbjct: 199 LAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFE 258
Query: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360
G KIGLFFWPKIT++DFKK+KLTLVVVEDDDQG+EQEHTFVFRLD + CKHLWKCAVE
Sbjct: 259 GDTKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVE 318
Query: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420
HHAFFRLR P S+RS FIRLGSRFR+SG+TEYQ T ++ RR+++FER+PSKRY SR
Sbjct: 319 HHAFFRLRGPVQKSSHRSGFIRLGSRFRYSGKTEYQTTKTNKARRSTSFERRPSKRY-SR 377
Query: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWH-----PHSPNV 469
R KA C+ T PE + + SQ W P SP++
Sbjct: 378 RTLQMKA---------CA-TKPEELSVHNNVSTQSNGSQQAWGMRSALPVSPSI 421
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 279 bits (714), Expect = 4e-75
Identities = 151/377 (40%), Positives = 222/377 (58%), Gaps = 17/377 (4%)
Query: 80 AAKATLYCRVFLLDGTEVSVD-----LPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSA 134
A YC V LLD +++++ + K KG + D + +H++LVE DYFGL++ D +
Sbjct: 6 AVPEEFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRS 65
Query: 135 QVAHWLDHAKPI---KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILS 191
+WLD AK + K+ + GP Y L+F +K+Y+ +P L+EE TRY F LQ++ D+L
Sbjct: 66 HQTYWLDPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQ 125
Query: 192 GKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECR 251
G+L CP TA +L A +Q+ELG+ + +HT VSE+RF+P+Q E +E I + K
Sbjct: 126 GRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLM 185
Query: 252 GKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWP 311
G+ P++AEL+YL AK LEMYGVD+H V G + EY LGLTP G+++++ ++G +FWP
Sbjct: 186 GQIPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWP 245
Query: 312 KITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL-RTP 370
+ITK+ FK+++ L V+ D E +F F S CKHLWKC+VEHH FFR+
Sbjct: 246 RITKVHFKETQFELRVLGKDC----NETSFFFEARSKTACKHLWKCSVEHHTFFRMPENE 301
Query: 371 GNSKSNR-SDFIRLGSRFRFSGRTEYQATHGSRL---RRTSTFERKPSKRYPSRRHSTFK 426
NS S + S F + + R+SGRT Q + + R R SK YP R T
Sbjct: 302 SNSLSRKLSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYPKRIAQTQP 361
Query: 427 ASNPVIAAQLCSKTNPE 443
A + I+ + N E
Sbjct: 362 AESNSISRITANMENGE 378
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 273 bits (698), Expect = 3e-73
Identities = 150/335 (44%), Positives = 207/335 (61%), Gaps = 7/335 (2%)
Query: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
T+ C+V LLDGTE S DL KHAKGQ LFD++ HL+L+E DYFGL F +S + +WLD A
Sbjct: 217 TVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPA 276
Query: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203
K IK+Q++ P + F VK+Y +P+ L E+ TRY LQLR DI SG+L C + T
Sbjct: 277 KEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHAL 335
Query: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
L + LQAELG+ + EH +SEF+F P QT+ +E + + K RG SPAQA+ +L
Sbjct: 336 LGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFL 395
Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
AK L MYGVD+H + +G + LG+ G+LI++ +I F WPKI K+ +K+S
Sbjct: 396 ENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF 455
Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
+ V + + + E T F+L + R K LWK VEHH F+RL +P + ++ F+ L
Sbjct: 456 YIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSP--EQPPKAKFLTL 511
Query: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
GS+FR+SGRT+ Q S L R FER SKR
Sbjct: 512 GSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR 546
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 273 bits (698), Expect = 3e-73
Identities = 150/335 (44%), Positives = 207/335 (61%), Gaps = 7/335 (2%)
Query: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
T+ C+V LLDGTE S DL KHAKGQ LFD++ HL+L+E DYFGL F +S + +WLD A
Sbjct: 217 TVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPA 276
Query: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203
K IK+Q++ P + F VK+Y +P+ L E+ TRY LQLR DI SG+L C + T
Sbjct: 277 KEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHAL 335
Query: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
L + LQAELG+ + EH +SEF+F P QT+ +E + + K RG SPAQA+ +L
Sbjct: 336 LGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFL 395
Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
AK L MYGVD+H + +G + LG+ G+LI++ +I F WPKI K+ +K+S
Sbjct: 396 ENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF 455
Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
+ V + + + E T F+L + R K LWK VEHH F+RL +P + ++ F+ L
Sbjct: 456 YIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSP--EQPPKAKFLTL 511
Query: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
GS+FR+SGRT+ Q S L R FER SKR
Sbjct: 512 GSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR 546
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 273 bits (698), Expect = 3e-73
Identities = 150/335 (44%), Positives = 207/335 (61%), Gaps = 7/335 (2%)
Query: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
T+ C+V LLDGTE S DL KHAKGQ LFD++ HL+L+E DYFGL F +S + +WLD A
Sbjct: 217 TVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPA 276
Query: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203
K IK+Q++ P + F VK+Y +P+ L E+ TRY LQLR DI SG+L C + T
Sbjct: 277 KEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHAL 335
Query: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
L + LQAELG+ + EH +SEF+F P QT+ +E + + K RG SPAQA+ +L
Sbjct: 336 LGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFL 395
Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
AK L MYGVD+H + +G + LG+ G+LI++ +I F WPKI K+ +K+S
Sbjct: 396 ENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF 455
Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
+ V + + + E T F+L + R K LWK VEHH F+RL +P + ++ F+ L
Sbjct: 456 YIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSP--EQPPKAKFLTL 511
Query: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
GS+FR+SGRT+ Q S L R FER SKR
Sbjct: 512 GSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR 546
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 269 bits (687), Expect = 5e-72
Identities = 142/340 (41%), Positives = 207/340 (60%), Gaps = 8/340 (2%)
Query: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
++ C+V LLDG+E + D+ K ++GQ LFD++ HL+L+E DYFGL + D+ +WLD A
Sbjct: 109 SMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPA 168
Query: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203
K IKKQ++ G A+ F VK+Y +P L E+ TRY LQLR DI+SG+L C + T
Sbjct: 169 KEIKKQVRSG-AWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLAL 227
Query: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
L + +Q+ELG+ + E + +SEFRF PN T+ +E + + K RG +PA+AE+ +L
Sbjct: 228 LGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFL 287
Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
AK L MYGVD+H + +G E LG+ +G+LI+ +I F WPK+ K+ +K++
Sbjct: 288 ENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNF 347
Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
+ + + + + E T F+L + R K LWK VEHH FFRL P ++ F+ L
Sbjct: 348 YIKIRPGEFE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLP---EAPPKKFLTL 402
Query: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421
GS+FR+SGRT+ Q S L R FER SKRY R
Sbjct: 403 GSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSR 442
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 265 bits (676), Expect = 1e-70
Identities = 142/337 (42%), Positives = 199/337 (59%), Gaps = 8/337 (2%)
Query: 87 CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146
CRV LLD +E ++ KH +GQ LFD + HL+L+E DYFGL F D+ +WLD +K I
Sbjct: 37 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 96
Query: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206
KKQ++ P + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L +
Sbjct: 97 KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 155
Query: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKA 266
+QAELG+ + EH VSE RF PNQT +E I + K RG +P +AE+ +L A
Sbjct: 156 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 215
Query: 267 KWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLV 326
K L MYGVD+H + +G + LG+ G+LI+ +I F WPKI K+ +K+S +
Sbjct: 216 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 275
Query: 327 VVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSR 386
+ + + + E T F+L + R+ K LWK +EHH FFRL +P + F+ +GS+
Sbjct: 276 IRPGEYE--QFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSP---EPPPKGFLVMGSK 330
Query: 387 FRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421
FR+SGRT+ Q S L R FER SKRY R
Sbjct: 331 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 367
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 265 bits (676), Expect = 1e-70
Identities = 142/337 (42%), Positives = 199/337 (59%), Gaps = 8/337 (2%)
Query: 87 CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146
CRV LLD +E ++ KH +GQ LFD + HL+L+E DYFGL F D+ +WLD +K I
Sbjct: 99 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 158
Query: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206
KKQ++ P + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L +
Sbjct: 159 KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 217
Query: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKA 266
+QAELG+ + EH VSE RF PNQT +E I + K RG +P +AE+ +L A
Sbjct: 218 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 277
Query: 267 KWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLV 326
K L MYGVD+H + +G + LG+ G+LI+ +I F WPKI K+ +K+S +
Sbjct: 278 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 337
Query: 327 VVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSR 386
+ + + + E T F+L + R+ K LWK +EHH FFRL +P + F+ +GS+
Sbjct: 338 IRPGEYE--QFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSP---EPPPKGFLVMGSK 392
Query: 387 FRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421
FR+SGRT+ Q S L R FER SKRY R
Sbjct: 393 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 429
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 261 bits (666), Expect = 1e-69
Identities = 143/357 (40%), Positives = 211/357 (59%), Gaps = 10/357 (2%)
Query: 67 LTGGAAVHISAAGAAK----ATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVE 122
L G ++ A+ A+ + C + LLD T + + KH +GQ L D + HLDL E
Sbjct: 7 LPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTE 66
Query: 123 TDYFGLQFLD-SAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLF 181
DYFGLQ D S WLD KPI+KQ+K G Y+L+FRVK++ S+PN L+EE+TRY +
Sbjct: 67 QDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQY 126
Query: 182 VLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEF 241
LQ++ DIL+G+L CP TA LA+ +Q+ELG+ + E+ +S++ FIPNQ + E
Sbjct: 127 FLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEK 186
Query: 242 DIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEG 301
+I + ++ G SPA+AE +YLN A+ LE+YGV+ H R + E +G+ GILI++
Sbjct: 187 EIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKN 246
Query: 302 ANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEH 361
++ F W KI K+ FK + + + ++ + RE F + + R CK+LWK VEH
Sbjct: 247 RVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRET--LLGFNMVNYRACKNLWKACVEH 304
Query: 362 HAFFRLRTPGNSKSN-RSDFIRLGSRFRFSGRTEYQATH--GSRLRRTSTFERKPSK 415
H FFRL P + N + + LGS+FR+ GRTE Q+ + + F R PSK
Sbjct: 305 HTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSK 361
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 258 bits (658), Expect = 1e-68
Identities = 138/334 (41%), Positives = 199/334 (59%), Gaps = 7/334 (2%)
Query: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
++C+V LLD T + KHAKGQDL ++ HL+L+E DYFGL D+A WLD AK
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
IKKQ++ G + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L
Sbjct: 61 EIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
+ +Q+ELG+ + H + VS+F+ PNQT+ +E + + K R +PAQA+L +L
Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179
Query: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLT 324
AK L MYGVD+H + +G + LG+ +G+L+++ +I F WPK+ K+ +K+S
Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239
Query: 325 LVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLG 384
+ + + + + E T F+L S R K LWK VEHH FFRL + +S F+ LG
Sbjct: 240 IKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTIPKSKFLALG 295
Query: 385 SRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
S+FR+SGRT+ Q S L R FER SKR
Sbjct: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 329
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 258 bits (658), Expect = 1e-68
Identities = 138/334 (41%), Positives = 199/334 (59%), Gaps = 7/334 (2%)
Query: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
++C+V LLD T + KHAKGQDL ++ HL+L+E DYFGL D+A WLD AK
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
IKKQ++ G + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L
Sbjct: 61 EIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
+ +Q+ELG+ + H + VS+F+ PNQT+ +E + + K R +PAQA+L +L
Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179
Query: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLT 324
AK L MYGVD+H + +G + LG+ +G+L+++ +I F WPK+ K+ +K+S
Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239
Query: 325 LVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLG 384
+ + + + + E T F+L S R K LWK VEHH FFRL + +S F+ LG
Sbjct: 240 IKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTIPKSKFLALG 295
Query: 385 SRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
S+FR+SGRT+ Q S L R FER SKR
Sbjct: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 329
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 231 bits (589), Expect = 1e-60
Identities = 131/369 (35%), Positives = 195/369 (52%), Gaps = 14/369 (3%)
Query: 76 SAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQ 135
S+ + + C + LLD +E+S + + KGQ L D I + L+E DYFG++++D +
Sbjct: 23 SSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEK 82
Query: 136 VAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLK 195
HWL+ K I KQMK P Y + FRVK+Y EP ++EE TRYL LQ++ DI G+L
Sbjct: 83 QRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLL 142
Query: 196 CPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWK-ECRGKS 254
C + A L A +QAELG+ + EH +SEF P Q++ +E I + K E RG+S
Sbjct: 143 CSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQS 202
Query: 255 PAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKIT 314
P AE + L KA LE YGVD H + G LG T G ++F+G +I L WP +
Sbjct: 203 PPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVC 262
Query: 315 KMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSK 374
K+ F+ ++ + +E++ F + CKHLWKC VE+ AF++ K
Sbjct: 263 KLKFEGKTFYVIGTQ-----KEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIK 317
Query: 375 S-NRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIA 433
+ + S GSRFR+SG+ + S S +R+P + + R + T S+ +
Sbjct: 318 TVSSSKIFFKGSRFRYSGKVAKEVVEAS-----SKIQREPPEVH--RANITQSRSSHSLN 370
Query: 434 AQLCSKTNP 442
QL P
Sbjct: 371 KQLIINMEP 379
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 227 bits (579), Expect = 2e-59
Identities = 126/351 (35%), Positives = 197/351 (56%), Gaps = 11/351 (3%)
Query: 87 CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146
C V LLD +E + + + AKGQ LFD + +HL+L+E DYFG++F+D + HWL+ K +
Sbjct: 19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78
Query: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206
KQ++ P + + FRVK+Y ++P L+EE TRYL LQ++ D+ G+L C A LAA
Sbjct: 79 VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138
Query: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWK-ECRGKSPAQAELSYLNK 265
LQAE+G+ + +H S+F+F P +E +E I + K E G++PA +EL++L K
Sbjct: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198
Query: 266 AKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTL 325
A+ LE YGVD H + G L TP G ++ +G ++ W ++TK+ F+ L
Sbjct: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258
Query: 326 VVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKS-NRSDFIRLG 384
V Q E++ + + CKHLWKC +E+ AF++L ++ + S+ G
Sbjct: 259 YV----SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKG 314
Query: 385 SRFRFSGRTEYQATHGS-RLRRTSTFERK----PSKRYPSRRHSTFKASNP 430
SRFR+SGR + S +++R + PS+ PS H +S P
Sbjct: 315 SRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVP 365
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 211 bits (537), Expect = 1e-54
Identities = 140/426 (32%), Positives = 225/426 (52%), Gaps = 18/426 (4%)
Query: 88 RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147
++ +LD T+ + ++P+ A G+ L D + HL+LVE DYFGL+F D ++ WLD KPI
Sbjct: 43 KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIV 102
Query: 148 KQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAAL 207
KQ++ + F VK++ + L+EE TRYLF LQ++ D+ G+L C +A L +
Sbjct: 103 KQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISH 162
Query: 208 CLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKAK 267
+Q+E+G+ + E +++ ++IP Q +A+E I + G++PA+++ L A+
Sbjct: 163 IVQSEIGDFD-EALDREHLAKNKYIPQQ-DALEDKIVEFHHNHIGQTPAESDFQLLEIAR 220
Query: 268 WLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVV 327
LEMYG+ +H + R+G + +L + TGIL+F+G KI F W K+ K+ FK+ + L+
Sbjct: 221 RLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRF-LIK 279
Query: 328 VEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSRF 387
+ D Q+ T F + S CK WK VEHHAFFRL K F R GS F
Sbjct: 280 LRPDANSAYQD-TLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSR-GSSF 337
Query: 388 RFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRRHSTFKAS-NPVIAAQLCSKT---- 440
RFSGRT+ Q + + FERK SK + R ++ N + Q T
Sbjct: 338 RFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTF 397
Query: 441 -----NPEVHNYQPQYHPNIHPSQPRWHPHSPNVRPSFQDDRSHWKASASGDDSHFDYVH 495
+P + + P + +P HP SP R S ++ A+++ + + V
Sbjct: 398 GEGAESPGGQSCRRGKEPKVSAGEPGSHP-SPAPRRSPAGNKQADGAASAPTEEEEEVVK 456
Query: 496 DQNQKN 501
D+ Q++
Sbjct: 457 DRTQQS 462
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 210 bits (535), Expect = 2e-54
Identities = 114/283 (40%), Positives = 166/283 (58%), Gaps = 7/283 (2%)
Query: 136 VAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLK 195
V WLD AK IKKQ++ G + F VK+Y +P L E+ TRY LQLR DI++G+L
Sbjct: 226 VETWLDSAKEIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLP 284
Query: 196 CPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSP 255
C + T L + +Q+ELG+ + H + VS+F+ PNQT+ +E + + K R +P
Sbjct: 285 CSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTP 344
Query: 256 AQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITK 315
AQA+L +L AK L MYGVD+H + +G + LG+ +G+L+++ +I F WPK+ K
Sbjct: 345 AQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLK 404
Query: 316 MDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKS 375
+ +K+S + + + + + E T F+L S R K LWK VEHH FFRL +
Sbjct: 405 ISYKRSSFFIKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTI 460
Query: 376 NRSDFIRLGSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
+S F+ LGS+FR+SGRT+ Q S L R FER SKR
Sbjct: 461 PKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 503
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 201 bits (512), Expect = 1e-51
Identities = 122/344 (35%), Positives = 191/344 (55%), Gaps = 10/344 (2%)
Query: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
L+ RV LLD T D+ GQ L Q+ L+LVE DYFG++F ++ WL+ K
Sbjct: 44 LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMK 103
Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
PI +Q++ L VK++ +P L+EE+TRYLF LQL+ D+L +L C TA L
Sbjct: 104 PIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALL 163
Query: 205 AALCLQAELGECELPEHTPEL-VSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
+ LQ+E+G+ + L V+E ++P Q +E I + ++ G++PA+++ L
Sbjct: 164 TSHLLQSEIGDYDETLDREHLKVNE--YLPGQQHCLE-KILEFHQKHVGQTPAESDFQVL 220
Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
A+ LEMYG+ H+ R+G + L ++ G+L+F+G KI F W K+ K+ FK+ +
Sbjct: 221 EIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRF 280
Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
L+ + + G Q+ T F L S CK+ WK VE+H FFRL K+ ++ F
Sbjct: 281 -LIKLHPEVHGPYQD-TLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKA-KAVFFSR 337
Query: 384 GSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKA 427
GS FR+SGRT+ Q + S +R P +R S+ H++ +A
Sbjct: 338 GSSFRYSGRTQKQLVD---YFKDSGMKRIPYERRHSKTHTSVRA 378
>gi|34916000 FERM domain containing 7 [Homo sapiens]
Length = 714
Score = 193 bits (490), Expect = 4e-49
Identities = 132/414 (31%), Positives = 206/414 (49%), Gaps = 29/414 (7%)
Query: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
L+ +V LD ++ + + + G+ LF+ HL+L E +YFGL+F + WL+ K
Sbjct: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
PI KQ+K F VK++ +P +LREE TRYLF LQ++ D+ G+L C +
Sbjct: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
+ LQ+ELG+ E + +++ R++PNQ + +E I ++ G+SPA++++ L+
Sbjct: 122 VSHILQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLD 179
Query: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL- 323
A+ L+MYG+ H +G + L + G+L+ G KI F W KI K+ FK+
Sbjct: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239
Query: 324 ------TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNR 377
LV+ +D T F + S CK WK VE+HAFFRL SK +
Sbjct: 240 IKLHANILVLCKD---------TLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKP-K 289
Query: 378 SDFIRLGSRFRFSGRTEYQATHGSRLRRTST--FERKPSKRYPSRRHSTFKASNPVIAAQ 435
+ GS FR+SGRT+ Q R R + FER K YPS+ H S+P + +
Sbjct: 290 TLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFER---KHYPSQYHERQCRSSPDLLSD 346
Query: 436 LCSKTNPEVHNYQPQYHPN---IHPSQPRWHPHSPN--VRPSFQDDRSHWKASA 484
+ + Y Y+ N +H S+P N + +F + H K A
Sbjct: 347 VSKQVEDLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEA 400
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 191 bits (485), Expect = 1e-48
Identities = 112/348 (32%), Positives = 180/348 (51%), Gaps = 11/348 (3%)
Query: 82 KATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLD-SAQVAHWL 140
++ + C + LDG + + K GQ L D + HL + E +YFGLQ D S WL
Sbjct: 26 RSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWL 85
Query: 141 DHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYET 200
+ +K I+KQ+K G LHFRV+++ +PN L++E TR+L+ LQL+ DI G+L CP +
Sbjct: 86 EASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNS 145
Query: 201 AVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAEL 260
AV LA+ +Q+ G+ H P +S+ FIP+Q E + ++ G ++AE
Sbjct: 146 AVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAES 205
Query: 261 SYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKK 320
Y+N A+ L+ YGV++H R + +G+ G+ ++ + W I K+ FK+
Sbjct: 206 CYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKR 265
Query: 321 SKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL-RTPGNSKSNRSD 379
K + + Q +EH F + + R+CK+LWK VEHH FF+ + K+ S
Sbjct: 266 KK--FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQ 323
Query: 380 FIRLGSR-FRFSGRTEY------QATHGSRLRRTSTFERKPSKRYPSR 420
+ +GSR + S +Y +RR+ + E +K PSR
Sbjct: 324 YWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSR 371
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 190 bits (482), Expect = 3e-48
Identities = 114/380 (30%), Positives = 185/380 (48%), Gaps = 24/380 (6%)
Query: 82 KATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLD-SAQVAHWL 140
++ + C + LDG + + K GQ L D + HL + E +YFGLQ D S WL
Sbjct: 26 RSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWL 85
Query: 141 DHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYET 200
+ +K I+KQ+K G LHFRV+++ +PN L++E TR+L+ LQL+ DI G+L CP +
Sbjct: 86 EASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNS 145
Query: 201 AVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAEL 260
AV LA+ +Q+ G+ H P +S+ FIP+Q E + ++ G ++AE
Sbjct: 146 AVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAES 205
Query: 261 SYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKK 320
Y+N A+ L+ YGV++H R + +G+ G+ ++ + W I K+ FK+
Sbjct: 206 CYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKR 265
Query: 321 SKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL-RTPGNSKSNRSD 379
K + + Q +EH F + + R+CK+LWK VEHH FF+ + K+ S
Sbjct: 266 KK--FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQ 323
Query: 380 FIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIAAQLCSK 439
+ +GSR +T +R P R+ R+ A N ++
Sbjct: 324 YWTMGSR--------------------NTKKRSPRLRHEIRKPRHSSADNLANEMTYITE 363
Query: 440 TNPEVHNYQPQYHPNIHPSQ 459
T + Y+ P S+
Sbjct: 364 TEDVFYTYKGSLAPQDSDSE 383
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 130 bits (327), Expect = 3e-30
Identities = 83/297 (27%), Positives = 145/297 (48%), Gaps = 17/297 (5%)
Query: 80 AAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHW 139
++K+ L R+ LL+ V L + GQ+ + + L+L E YF L + + W
Sbjct: 18 SSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRW 77
Query: 140 LDHAKPIKKQM-KIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPY 198
+D KP+KKQ+ K ++F V +Y + L++E TRY + LQL+ DIL G + C
Sbjct: 78 VDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTL 137
Query: 199 ETAVELAALCLQAELGECELPEHTPELVSEFRFIP---NQTEAMEFDIFQR----WKECR 251
E A++LA L +QA+ G+ + E + + + +F P Q E + + Q+ ++ R
Sbjct: 138 EQAIQLAGLAVQADFGDFDQYE-SQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYR 196
Query: 252 GKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILI-FEGANKIGLFFW 310
G + AE+ Y+ + + ++ YG + + + G + S+G GI + + +F W
Sbjct: 197 GLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRW 256
Query: 311 PKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL 367
I M KS L + +E T F+ + T K++W+ V H F+RL
Sbjct: 257 HDIANMSHNKSFFALELA-------NKEETIQFQTEDMETAKYIWRLCVARHKFYRL 306
>gi|34328899 protein tyrosine phosphatase, non-receptor type 14
[Homo sapiens]
Length = 1187
Score = 126 bits (317), Expect = 4e-29
Identities = 86/314 (27%), Positives = 149/314 (47%), Gaps = 23/314 (7%)
Query: 81 AKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWL 140
+K R+ LLD + L + GQ+ + + L+L ET YFGL FL +Q A W+
Sbjct: 17 SKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWV 76
Query: 141 DHAKPIKKQM-KIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYE 199
+ KP+KK + K L F V +Y + L++E TRY + LQ++ D+L G+L+C +
Sbjct: 77 ELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLD 136
Query: 200 TAVELAALCLQAELGECELPEHTPELVSEFRFIPNQ-------TEAMEFDIFQRWKECRG 252
+ LA L +QA+ G+ + + + + E+ P E + + Q K G
Sbjct: 137 QVIRLAGLAVQADFGDYNQFD-SQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSG 195
Query: 253 KSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIG----LF 308
PA+AEL Y+N+ + L+ +G ++ V+ G LG+ GI + N+IG ++
Sbjct: 196 ILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFV---RNRIGRQAVIY 252
Query: 309 FWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLR 368
W + + KS + + ++ +E T +F D K++ + H F++
Sbjct: 253 RWNDMGNITHNKSTILVELI-------NKEETALFHTDDIENAKYISRLFATRHKFYKQN 305
Query: 369 TPGNSKSNRSDFIR 382
+SN IR
Sbjct: 306 KICTEQSNSPPPIR 319
>gi|38788243 myosin regulatory light chain interacting protein [Homo
sapiens]
Length = 445
Score = 125 bits (314), Expect = 9e-29
Identities = 88/289 (30%), Positives = 138/289 (47%), Gaps = 14/289 (4%)
Query: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
+ C V D + V++ A G+D +Q+ L ++E DYFGLQF S + WL+
Sbjct: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRN 60
Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
I +QM Y L RVK++ EP+ + +E TR++F L ++ +L+G L C E AVEL
Sbjct: 61 RISQQMDGLAPYRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVEL 119
Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
+AL Q + G+ ++T + E + A I + KE G S A AE L
Sbjct: 120 SALLAQTKFGDYN--QNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQ 177
Query: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILI----FEGANKIGLFFWPKITKMDFKK 320
+E YG++ H VR +G + +G+ P GI I F N+I +P +
Sbjct: 178 IVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIA---YPVVQMATQSG 234
Query: 321 SKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRT 369
+ L V ++ +F++ S R L++ E HAF+R T
Sbjct: 235 KNVYLTVTKESG----NSIVLLFKMISTRAASGLYRAITETHAFYRCDT 279
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 116 bits (291), Expect = 4e-26
Identities = 91/298 (30%), Positives = 146/298 (48%), Gaps = 23/298 (7%)
Query: 88 RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147
RV +D E+ + + G+ LFDQ+V + L E +FGLQ++DS + WL K +
Sbjct: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVT 66
Query: 148 KQ-MKIGPAYALHFRVKYYSSEPNN-LREEFTRYLFVLQLRHDILSGKLKCPYETAVELA 205
+Q +K FR K++ + + L +E T+ LF LQ++ IL+ ++ CP ETAV LA
Sbjct: 67 QQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLA 126
Query: 206 ALCLQAELGECELPEHTPELVSEFRFIPNQ-------TEAMEFDIFQRW-KECRGKSPAQ 257
+ +QA+ G+ H P ++ R +P + T+ + Q W +E RG
Sbjct: 127 SYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLRED 186
Query: 258 AELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGAN----KIGLFFWPKI 313
+ + YL A+ LEMYGV+ ++ + G E LG+ G+ I+E + KIG F W +I
Sbjct: 187 SMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIG-FPWSEI 245
Query: 314 TKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKH-LWKCAVEHHAFFRLRTP 370
+ F K + ++ ++ FVF R K L C H + R R P
Sbjct: 246 RNISFNDKKFVIKPID------KKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKP 297
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 113 bits (283), Expect = 4e-25
Identities = 70/241 (29%), Positives = 116/241 (48%), Gaps = 10/241 (4%)
Query: 188 DILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRW 247
DI G+L CP +AV LA+ +Q+ G+ H P +S+ FIP+Q E +
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 248 KECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGL 307
++ G ++AE Y+N A+ L+ YGV++H R + +G+ G+ ++
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 308 FFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL 367
+ W I K+ FK+ K + + Q +EH F + + R+CK+LWK VEHH FF+
Sbjct: 122 YPWVNILKISFKRKK--FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQA 179
Query: 368 -RTPGNSKSNRSDFIRLGSR-FRFSGRTEY------QATHGSRLRRTSTFERKPSKRYPS 419
+ K+ S + +GSR + S +Y +RR+ + E +K PS
Sbjct: 180 KKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPS 239
Query: 420 R 420
R
Sbjct: 240 R 240
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 113 bits (282), Expect = 5e-25
Identities = 92/299 (30%), Positives = 139/299 (46%), Gaps = 25/299 (8%)
Query: 88 RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147
RV +D E+ + + G+ LFDQ+V + L E YFGL ++D+ WL K +
Sbjct: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS 66
Query: 148 KQ--MKIGPAYALHFRVKYYSSE-PNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
Q K P FR K+Y + L ++ T+ LF LQ++ ILS ++ CP ETAV L
Sbjct: 67 AQEVRKENPLQ-FKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLL 125
Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQ-------TEAMEFDIFQRW-KECRGKSPA 256
+ +QA+ G+ H +S R IP + T D Q W E RG
Sbjct: 126 GSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKD 185
Query: 257 QAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGAN----KIGLFFWPK 312
A L YL A+ LEMYG++ ++ + G + LG+ G+ I+E + KIG F W +
Sbjct: 186 NAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIG-FPWSE 244
Query: 313 ITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWK-CAVEHHAFFRLRTP 370
I + F K + ++ ++ FVF R K + + C H + R R P
Sbjct: 245 IRNISFNDKKFVIKPID------KKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKP 297
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 113 bits (282), Expect = 5e-25
Identities = 92/299 (30%), Positives = 139/299 (46%), Gaps = 25/299 (8%)
Query: 88 RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147
RV +D E+ + + G+ LFDQ+V + L E YFGL ++D+ WL K +
Sbjct: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS 66
Query: 148 KQ--MKIGPAYALHFRVKYYSSE-PNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
Q K P FR K+Y + L ++ T+ LF LQ++ ILS ++ CP ETAV L
Sbjct: 67 AQEVRKENPLQ-FKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLL 125
Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQ-------TEAMEFDIFQRW-KECRGKSPA 256
+ +QA+ G+ H +S R IP + T D Q W E RG
Sbjct: 126 GSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKD 185
Query: 257 QAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGAN----KIGLFFWPK 312
A L YL A+ LEMYG++ ++ + G + LG+ G+ I+E + KIG F W +
Sbjct: 186 NAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIG-FPWSE 244
Query: 313 ITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWK-CAVEHHAFFRLRTP 370
I + F K + ++ ++ FVF R K + + C H + R R P
Sbjct: 245 IRNISFNDKKFVIKPID------KKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKP 297
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 112 bits (281), Expect = 6e-25
Identities = 83/302 (27%), Positives = 141/302 (46%), Gaps = 19/302 (6%)
Query: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
T R+ +D E+ + KG+DLFD + L L ET +FGLQ+ VA
Sbjct: 21 TFTVRIVTMDA-EMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDK 79
Query: 144 KPIKKQMKIGPAYALHFRVKYY-SSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAV 202
K + + HF K+Y + L +E T++LF LQ++ IL K+ CP E +V
Sbjct: 80 KVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASV 139
Query: 203 ELAALCLQAELGECELPEHTPELVSEFRFIPNQT--------EAMEFDIFQRWKECRGKS 254
LA+ +QA+ G+ + H +++ +P + E E I + E RG++
Sbjct: 140 LLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRA 199
Query: 255 PAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIG---LFFWP 311
+AE+ YL A+ LEMYGV+ +R + G E LG+ G+ I++ N++ F W
Sbjct: 200 RDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWN 259
Query: 312 KITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPG 371
+I + + + T+ ++ ++ F F R K + + + +H F R
Sbjct: 260 EIRNISYSDKEFTIKPLD------KKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKA 313
Query: 372 NS 373
+S
Sbjct: 314 DS 315
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 112 bits (281), Expect = 6e-25
Identities = 83/302 (27%), Positives = 141/302 (46%), Gaps = 19/302 (6%)
Query: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
T R+ +D E+ + KG+DLFD + L L ET +FGLQ+ VA
Sbjct: 21 TFTVRIVTMDA-EMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDK 79
Query: 144 KPIKKQMKIGPAYALHFRVKYY-SSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAV 202
K + + HF K+Y + L +E T++LF LQ++ IL K+ CP E +V
Sbjct: 80 KVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASV 139
Query: 203 ELAALCLQAELGECELPEHTPELVSEFRFIPNQT--------EAMEFDIFQRWKECRGKS 254
LA+ +QA+ G+ + H +++ +P + E E I + E RG++
Sbjct: 140 LLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRA 199
Query: 255 PAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIG---LFFWP 311
+AE+ YL A+ LEMYGV+ +R + G E LG+ G+ I++ N++ F W
Sbjct: 200 RDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWN 259
Query: 312 KITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPG 371
+I + + + T+ ++ ++ F F R K + + + +H F R
Sbjct: 260 EIRNISYSDKEFTIKPLD------KKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKA 313
Query: 372 NS 373
+S
Sbjct: 314 DS 315
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,101,421
Number of Sequences: 37866
Number of extensions: 1046031
Number of successful extensions: 6506
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 99
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 5711
Number of HSP's gapped (non-prelim): 649
length of query: 518
length of database: 18,247,518
effective HSP length: 107
effective length of query: 411
effective length of database: 14,195,856
effective search space: 5834496816
effective search space used: 5834496816
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.