BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform 1 [Homo sapiens] (518 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 1073 0.0 gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 970 0.0 gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 553 e-157 gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 279 4e-75 gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 273 3e-73 gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 273 3e-73 gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 273 3e-73 gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 269 5e-72 gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 265 1e-70 gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 265 1e-70 gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 261 1e-69 gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 258 1e-68 gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 258 1e-68 gi|117500790 FERM domain containing 3 [Homo sapiens] 231 1e-60 gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 227 2e-59 gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 211 1e-54 gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 210 2e-54 gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 201 1e-51 gi|34916000 FERM domain containing 7 [Homo sapiens] 193 4e-49 gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 191 1e-48 gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 190 3e-48 gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 130 3e-30 gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 126 4e-29 gi|38788243 myosin regulatory light chain interacting protein [H... 125 9e-29 gi|4506467 radixin [Homo sapiens] 116 4e-26 gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 113 4e-25 gi|161702986 ezrin [Homo sapiens] 113 5e-25 gi|21614499 ezrin [Homo sapiens] 113 5e-25 gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 112 6e-25 gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 112 6e-25 >gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform 1 [Homo sapiens] Length = 518 Score = 1073 bits (2774), Expect = 0.0 Identities = 518/518 (100%), Positives = 518/518 (100%) Query: 1 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP Sbjct: 1 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60 Query: 61 AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120 AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL Sbjct: 61 AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120 Query: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL Sbjct: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180 Query: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME Sbjct: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240 Query: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE Sbjct: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300 Query: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE Sbjct: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360 Query: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR Sbjct: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420 Query: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVRPSFQDDRSHW 480 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVRPSFQDDRSHW Sbjct: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVRPSFQDDRSHW 480 Query: 481 KASASGDDSHFDYVHDQNQKNLGGMQSMMYRDKLMTAL 518 KASASGDDSHFDYVHDQNQKNLGGMQSMMYRDKLMTAL Sbjct: 481 KASASGDDSHFDYVHDQNQKNLGGMQSMMYRDKLMTAL 518 >gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform 2 [Homo sapiens] Length = 900 Score = 970 bits (2507), Expect = 0.0 Identities = 469/469 (100%), Positives = 469/469 (100%) Query: 1 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP Sbjct: 1 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60 Query: 61 AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120 AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL Sbjct: 61 AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120 Query: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL Sbjct: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180 Query: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME Sbjct: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240 Query: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE Sbjct: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300 Query: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE Sbjct: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360 Query: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR Sbjct: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420 Query: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNV 469 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNV Sbjct: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNV 469 >gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo sapiens] Length = 733 Score = 553 bits (1426), Expect = e-157 Identities = 289/474 (60%), Positives = 340/474 (71%), Gaps = 58/474 (12%) Query: 1 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60 ML F RRT GRRSM+++A R A Sbjct: 1 MLSFFRRTLGRRSMRKHAEKERLREAQR-------------------------------- 28 Query: 61 AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120 AA HI AAG +K+ + CRV LLDGT+VSVDLPK AKGQ+LFDQI+YHLDL Sbjct: 29 ----------AATHIPAAGDSKSIITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDL 78 Query: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180 +E+DYFGL+F+DSAQVAHWLD K IKKQ+KIG Y LH RVK+YSSEPNNLREE TRYL Sbjct: 79 IESDYFGLRFMDSAQVAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYL 138 Query: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240 FVLQL+ DILSGKL CP++TAV+LAA LQAELG+ +L EH+PELVSEFRF+P QTE ME Sbjct: 139 FVLQLKQDILSGKLDCPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEME 198 Query: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300 IF++WKE RG++PAQAE +YLNKAKWLEMYGVDMHVV+ RDG +YSLGLTPTG+L+FE Sbjct: 199 LAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFE 258 Query: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360 G KIGLFFWPKIT++DFKK+KLTLVVVEDDDQG+EQEHTFVFRLD + CKHLWKCAVE Sbjct: 259 GDTKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVE 318 Query: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420 HHAFFRLR P S+RS FIRLGSRFR+SG+TEYQ T ++ RR+++FER+PSKRY SR Sbjct: 319 HHAFFRLRGPVQKSSHRSGFIRLGSRFRYSGKTEYQTTKTNKARRSTSFERRPSKRY-SR 377 Query: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWH-----PHSPNV 469 R KA C+ T PE + + SQ W P SP++ Sbjct: 378 RTLQMKA---------CA-TKPEELSVHNNVSTQSNGSQQAWGMRSALPVSPSI 421 >gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] Length = 686 Score = 279 bits (714), Expect = 4e-75 Identities = 151/377 (40%), Positives = 222/377 (58%), Gaps = 17/377 (4%) Query: 80 AAKATLYCRVFLLDGTEVSVD-----LPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSA 134 A YC V LLD +++++ + K KG + D + +H++LVE DYFGL++ D + Sbjct: 6 AVPEEFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRS 65 Query: 135 QVAHWLDHAKPI---KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILS 191 +WLD AK + K+ + GP Y L+F +K+Y+ +P L+EE TRY F LQ++ D+L Sbjct: 66 HQTYWLDPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQ 125 Query: 192 GKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECR 251 G+L CP TA +L A +Q+ELG+ + +HT VSE+RF+P+Q E +E I + K Sbjct: 126 GRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLM 185 Query: 252 GKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWP 311 G+ P++AEL+YL AK LEMYGVD+H V G + EY LGLTP G+++++ ++G +FWP Sbjct: 186 GQIPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWP 245 Query: 312 KITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL-RTP 370 +ITK+ FK+++ L V+ D E +F F S CKHLWKC+VEHH FFR+ Sbjct: 246 RITKVHFKETQFELRVLGKDC----NETSFFFEARSKTACKHLWKCSVEHHTFFRMPENE 301 Query: 371 GNSKSNR-SDFIRLGSRFRFSGRTEYQATHGSRL---RRTSTFERKPSKRYPSRRHSTFK 426 NS S + S F + + R+SGRT Q + + R R SK YP R T Sbjct: 302 SNSLSRKLSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYPKRIAQTQP 361 Query: 427 ASNPVIAAQLCSKTNPE 443 A + I+ + N E Sbjct: 362 AESNSISRITANMENGE 378 >gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b [Homo sapiens] Length = 673 Score = 273 bits (698), Expect = 3e-73 Identities = 150/335 (44%), Positives = 207/335 (61%), Gaps = 7/335 (2%) Query: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143 T+ C+V LLDGTE S DL KHAKGQ LFD++ HL+L+E DYFGL F +S + +WLD A Sbjct: 217 TVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPA 276 Query: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203 K IK+Q++ P + F VK+Y +P+ L E+ TRY LQLR DI SG+L C + T Sbjct: 277 KEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHAL 335 Query: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263 L + LQAELG+ + EH +SEF+F P QT+ +E + + K RG SPAQA+ +L Sbjct: 336 LGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFL 395 Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323 AK L MYGVD+H + +G + LG+ G+LI++ +I F WPKI K+ +K+S Sbjct: 396 ENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF 455 Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383 + V + + + E T F+L + R K LWK VEHH F+RL +P + ++ F+ L Sbjct: 456 YIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSP--EQPPKAKFLTL 511 Query: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416 GS+FR+SGRT+ Q S L R FER SKR Sbjct: 512 GSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR 546 >gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b [Homo sapiens] Length = 673 Score = 273 bits (698), Expect = 3e-73 Identities = 150/335 (44%), Positives = 207/335 (61%), Gaps = 7/335 (2%) Query: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143 T+ C+V LLDGTE S DL KHAKGQ LFD++ HL+L+E DYFGL F +S + +WLD A Sbjct: 217 TVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPA 276 Query: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203 K IK+Q++ P + F VK+Y +P+ L E+ TRY LQLR DI SG+L C + T Sbjct: 277 KEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHAL 335 Query: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263 L + LQAELG+ + EH +SEF+F P QT+ +E + + K RG SPAQA+ +L Sbjct: 336 LGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFL 395 Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323 AK L MYGVD+H + +G + LG+ G+LI++ +I F WPKI K+ +K+S Sbjct: 396 ENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF 455 Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383 + V + + + E T F+L + R K LWK VEHH F+RL +P + ++ F+ L Sbjct: 456 YIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSP--EQPPKAKFLTL 511 Query: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416 GS+FR+SGRT+ Q S L R FER SKR Sbjct: 512 GSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR 546 >gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a [Homo sapiens] Length = 1005 Score = 273 bits (698), Expect = 3e-73 Identities = 150/335 (44%), Positives = 207/335 (61%), Gaps = 7/335 (2%) Query: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143 T+ C+V LLDGTE S DL KHAKGQ LFD++ HL+L+E DYFGL F +S + +WLD A Sbjct: 217 TVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPA 276 Query: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203 K IK+Q++ P + F VK+Y +P+ L E+ TRY LQLR DI SG+L C + T Sbjct: 277 KEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHAL 335 Query: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263 L + LQAELG+ + EH +SEF+F P QT+ +E + + K RG SPAQA+ +L Sbjct: 336 LGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFL 395 Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323 AK L MYGVD+H + +G + LG+ G+LI++ +I F WPKI K+ +K+S Sbjct: 396 ENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF 455 Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383 + V + + + E T F+L + R K LWK VEHH F+RL +P + ++ F+ L Sbjct: 456 YIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSP--EQPPKAKFLTL 511 Query: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416 GS+FR+SGRT+ Q S L R FER SKR Sbjct: 512 GSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR 546 >gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo sapiens] Length = 1087 Score = 269 bits (687), Expect = 5e-72 Identities = 142/340 (41%), Positives = 207/340 (60%), Gaps = 8/340 (2%) Query: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143 ++ C+V LLDG+E + D+ K ++GQ LFD++ HL+L+E DYFGL + D+ +WLD A Sbjct: 109 SMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPA 168 Query: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203 K IKKQ++ G A+ F VK+Y +P L E+ TRY LQLR DI+SG+L C + T Sbjct: 169 KEIKKQVRSG-AWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLAL 227 Query: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263 L + +Q+ELG+ + E + +SEFRF PN T+ +E + + K RG +PA+AE+ +L Sbjct: 228 LGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFL 287 Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323 AK L MYGVD+H + +G E LG+ +G+LI+ +I F WPK+ K+ +K++ Sbjct: 288 ENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNF 347 Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383 + + + + + E T F+L + R K LWK VEHH FFRL P ++ F+ L Sbjct: 348 YIKIRPGEFE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLP---EAPPKKFLTL 402 Query: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421 GS+FR+SGRT+ Q S L R FER SKRY R Sbjct: 403 GSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSR 442 >gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b [Homo sapiens] Length = 779 Score = 265 bits (676), Expect = 1e-70 Identities = 142/337 (42%), Positives = 199/337 (59%), Gaps = 8/337 (2%) Query: 87 CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146 CRV LLD +E ++ KH +GQ LFD + HL+L+E DYFGL F D+ +WLD +K I Sbjct: 37 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 96 Query: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206 KKQ++ P + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L + Sbjct: 97 KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 155 Query: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKA 266 +QAELG+ + EH VSE RF PNQT +E I + K RG +P +AE+ +L A Sbjct: 156 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 215 Query: 267 KWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLV 326 K L MYGVD+H + +G + LG+ G+LI+ +I F WPKI K+ +K+S + Sbjct: 216 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 275 Query: 327 VVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSR 386 + + + + E T F+L + R+ K LWK +EHH FFRL +P + F+ +GS+ Sbjct: 276 IRPGEYE--QFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSP---EPPPKGFLVMGSK 330 Query: 387 FRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421 FR+SGRT+ Q S L R FER SKRY R Sbjct: 331 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 367 >gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a [Homo sapiens] Length = 881 Score = 265 bits (676), Expect = 1e-70 Identities = 142/337 (42%), Positives = 199/337 (59%), Gaps = 8/337 (2%) Query: 87 CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146 CRV LLD +E ++ KH +GQ LFD + HL+L+E DYFGL F D+ +WLD +K I Sbjct: 99 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 158 Query: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206 KKQ++ P + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L + Sbjct: 159 KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 217 Query: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKA 266 +QAELG+ + EH VSE RF PNQT +E I + K RG +P +AE+ +L A Sbjct: 218 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 277 Query: 267 KWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLV 326 K L MYGVD+H + +G + LG+ G+LI+ +I F WPKI K+ +K+S + Sbjct: 278 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 337 Query: 327 VVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSR 386 + + + + E T F+L + R+ K LWK +EHH FFRL +P + F+ +GS+ Sbjct: 338 IRPGEYE--QFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSP---EPPPKGFLVMGSK 392 Query: 387 FRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421 FR+SGRT+ Q S L R FER SKRY R Sbjct: 393 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 429 >gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo sapiens] Length = 926 Score = 261 bits (666), Expect = 1e-69 Identities = 143/357 (40%), Positives = 211/357 (59%), Gaps = 10/357 (2%) Query: 67 LTGGAAVHISAAGAAK----ATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVE 122 L G ++ A+ A+ + C + LLD T + + KH +GQ L D + HLDL E Sbjct: 7 LPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTE 66 Query: 123 TDYFGLQFLD-SAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLF 181 DYFGLQ D S WLD KPI+KQ+K G Y+L+FRVK++ S+PN L+EE+TRY + Sbjct: 67 QDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQY 126 Query: 182 VLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEF 241 LQ++ DIL+G+L CP TA LA+ +Q+ELG+ + E+ +S++ FIPNQ + E Sbjct: 127 FLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEK 186 Query: 242 DIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEG 301 +I + ++ G SPA+AE +YLN A+ LE+YGV+ H R + E +G+ GILI++ Sbjct: 187 EIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKN 246 Query: 302 ANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEH 361 ++ F W KI K+ FK + + + ++ + RE F + + R CK+LWK VEH Sbjct: 247 RVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRET--LLGFNMVNYRACKNLWKACVEH 304 Query: 362 HAFFRLRTPGNSKSN-RSDFIRLGSRFRFSGRTEYQATH--GSRLRRTSTFERKPSK 415 H FFRL P + N + + LGS+FR+ GRTE Q+ + + F R PSK Sbjct: 305 HTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSK 361 >gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) isoform 2 [Homo sapiens] Length = 641 Score = 258 bits (658), Expect = 1e-68 Identities = 138/334 (41%), Positives = 199/334 (59%), Gaps = 7/334 (2%) Query: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144 ++C+V LLD T + KHAKGQDL ++ HL+L+E DYFGL D+A WLD AK Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60 Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204 IKKQ++ G + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L Sbjct: 61 EIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119 Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264 + +Q+ELG+ + H + VS+F+ PNQT+ +E + + K R +PAQA+L +L Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179 Query: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLT 324 AK L MYGVD+H + +G + LG+ +G+L+++ +I F WPK+ K+ +K+S Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239 Query: 325 LVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLG 384 + + + + + E T F+L S R K LWK VEHH FFRL + +S F+ LG Sbjct: 240 IKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTIPKSKFLALG 295 Query: 385 SRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416 S+FR+SGRT+ Q S L R FER SKR Sbjct: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 329 >gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) isoform 3 [Homo sapiens] Length = 588 Score = 258 bits (658), Expect = 1e-68 Identities = 138/334 (41%), Positives = 199/334 (59%), Gaps = 7/334 (2%) Query: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144 ++C+V LLD T + KHAKGQDL ++ HL+L+E DYFGL D+A WLD AK Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60 Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204 IKKQ++ G + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L Sbjct: 61 EIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119 Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264 + +Q+ELG+ + H + VS+F+ PNQT+ +E + + K R +PAQA+L +L Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179 Query: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLT 324 AK L MYGVD+H + +G + LG+ +G+L+++ +I F WPK+ K+ +K+S Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239 Query: 325 LVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLG 384 + + + + + E T F+L S R K LWK VEHH FFRL + +S F+ LG Sbjct: 240 IKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTIPKSKFLALG 295 Query: 385 SRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416 S+FR+SGRT+ Q S L R FER SKR Sbjct: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 329 >gi|117500790 FERM domain containing 3 [Homo sapiens] Length = 597 Score = 231 bits (589), Expect = 1e-60 Identities = 131/369 (35%), Positives = 195/369 (52%), Gaps = 14/369 (3%) Query: 76 SAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQ 135 S+ + + C + LLD +E+S + + KGQ L D I + L+E DYFG++++D + Sbjct: 23 SSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEK 82 Query: 136 VAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLK 195 HWL+ K I KQMK P Y + FRVK+Y EP ++EE TRYL LQ++ DI G+L Sbjct: 83 QRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLL 142 Query: 196 CPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWK-ECRGKS 254 C + A L A +QAELG+ + EH +SEF P Q++ +E I + K E RG+S Sbjct: 143 CSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQS 202 Query: 255 PAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKIT 314 P AE + L KA LE YGVD H + G LG T G ++F+G +I L WP + Sbjct: 203 PPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVC 262 Query: 315 KMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSK 374 K+ F+ ++ + +E++ F + CKHLWKC VE+ AF++ K Sbjct: 263 KLKFEGKTFYVIGTQ-----KEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIK 317 Query: 375 S-NRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIA 433 + + S GSRFR+SG+ + S S +R+P + + R + T S+ + Sbjct: 318 TVSSSKIFFKGSRFRYSGKVAKEVVEAS-----SKIQREPPEVH--RANITQSRSSHSLN 370 Query: 434 AQLCSKTNP 442 QL P Sbjct: 371 KQLIINMEP 379 >gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] Length = 570 Score = 227 bits (579), Expect = 2e-59 Identities = 126/351 (35%), Positives = 197/351 (56%), Gaps = 11/351 (3%) Query: 87 CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146 C V LLD +E + + + AKGQ LFD + +HL+L+E DYFG++F+D + HWL+ K + Sbjct: 19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78 Query: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206 KQ++ P + + FRVK+Y ++P L+EE TRYL LQ++ D+ G+L C A LAA Sbjct: 79 VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138 Query: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWK-ECRGKSPAQAELSYLNK 265 LQAE+G+ + +H S+F+F P +E +E I + K E G++PA +EL++L K Sbjct: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198 Query: 266 AKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTL 325 A+ LE YGVD H + G L TP G ++ +G ++ W ++TK+ F+ L Sbjct: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258 Query: 326 VVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKS-NRSDFIRLG 384 V Q E++ + + CKHLWKC +E+ AF++L ++ + S+ G Sbjct: 259 YV----SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKG 314 Query: 385 SRFRFSGRTEYQATHGS-RLRRTSTFERK----PSKRYPSRRHSTFKASNP 430 SRFR+SGR + S +++R + PS+ PS H +S P Sbjct: 315 SRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVP 365 >gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1 [Homo sapiens] Length = 1045 Score = 211 bits (537), Expect = 1e-54 Identities = 140/426 (32%), Positives = 225/426 (52%), Gaps = 18/426 (4%) Query: 88 RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147 ++ +LD T+ + ++P+ A G+ L D + HL+LVE DYFGL+F D ++ WLD KPI Sbjct: 43 KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIV 102 Query: 148 KQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAAL 207 KQ++ + F VK++ + L+EE TRYLF LQ++ D+ G+L C +A L + Sbjct: 103 KQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISH 162 Query: 208 CLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKAK 267 +Q+E+G+ + E +++ ++IP Q +A+E I + G++PA+++ L A+ Sbjct: 163 IVQSEIGDFD-EALDREHLAKNKYIPQQ-DALEDKIVEFHHNHIGQTPAESDFQLLEIAR 220 Query: 268 WLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVV 327 LEMYG+ +H + R+G + +L + TGIL+F+G KI F W K+ K+ FK+ + L+ Sbjct: 221 RLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRF-LIK 279 Query: 328 VEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSRF 387 + D Q+ T F + S CK WK VEHHAFFRL K F R GS F Sbjct: 280 LRPDANSAYQD-TLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSR-GSSF 337 Query: 388 RFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRRHSTFKAS-NPVIAAQLCSKT---- 440 RFSGRT+ Q + + FERK SK + R ++ N + Q T Sbjct: 338 RFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTF 397 Query: 441 -----NPEVHNYQPQYHPNIHPSQPRWHPHSPNVRPSFQDDRSHWKASASGDDSHFDYVH 495 +P + + P + +P HP SP R S ++ A+++ + + V Sbjct: 398 GEGAESPGGQSCRRGKEPKVSAGEPGSHP-SPAPRRSPAGNKQADGAASAPTEEEEEVVK 456 Query: 496 DQNQKN 501 D+ Q++ Sbjct: 457 DRTQQS 462 >gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) isoform 1 [Homo sapiens] Length = 775 Score = 210 bits (535), Expect = 2e-54 Identities = 114/283 (40%), Positives = 166/283 (58%), Gaps = 7/283 (2%) Query: 136 VAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLK 195 V WLD AK IKKQ++ G + F VK+Y +P L E+ TRY LQLR DI++G+L Sbjct: 226 VETWLDSAKEIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLP 284 Query: 196 CPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSP 255 C + T L + +Q+ELG+ + H + VS+F+ PNQT+ +E + + K R +P Sbjct: 285 CSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTP 344 Query: 256 AQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITK 315 AQA+L +L AK L MYGVD+H + +G + LG+ +G+L+++ +I F WPK+ K Sbjct: 345 AQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLK 404 Query: 316 MDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKS 375 + +K+S + + + + + E T F+L S R K LWK VEHH FFRL + Sbjct: 405 ISYKRSSFFIKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTI 460 Query: 376 NRSDFIRLGSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416 +S F+ LGS+FR+SGRT+ Q S L R FER SKR Sbjct: 461 PKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 503 >gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sapiens] Length = 1054 Score = 201 bits (512), Expect = 1e-51 Identities = 122/344 (35%), Positives = 191/344 (55%), Gaps = 10/344 (2%) Query: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144 L+ RV LLD T D+ GQ L Q+ L+LVE DYFG++F ++ WL+ K Sbjct: 44 LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMK 103 Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204 PI +Q++ L VK++ +P L+EE+TRYLF LQL+ D+L +L C TA L Sbjct: 104 PIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALL 163 Query: 205 AALCLQAELGECELPEHTPEL-VSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263 + LQ+E+G+ + L V+E ++P Q +E I + ++ G++PA+++ L Sbjct: 164 TSHLLQSEIGDYDETLDREHLKVNE--YLPGQQHCLE-KILEFHQKHVGQTPAESDFQVL 220 Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323 A+ LEMYG+ H+ R+G + L ++ G+L+F+G KI F W K+ K+ FK+ + Sbjct: 221 EIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRF 280 Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383 L+ + + G Q+ T F L S CK+ WK VE+H FFRL K+ ++ F Sbjct: 281 -LIKLHPEVHGPYQD-TLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKA-KAVFFSR 337 Query: 384 GSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKA 427 GS FR+SGRT+ Q + S +R P +R S+ H++ +A Sbjct: 338 GSSFRYSGRTQKQLVD---YFKDSGMKRIPYERRHSKTHTSVRA 378 >gi|34916000 FERM domain containing 7 [Homo sapiens] Length = 714 Score = 193 bits (490), Expect = 4e-49 Identities = 132/414 (31%), Positives = 206/414 (49%), Gaps = 29/414 (7%) Query: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144 L+ +V LD ++ + + + G+ LF+ HL+L E +YFGL+F + WL+ K Sbjct: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61 Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204 PI KQ+K F VK++ +P +LREE TRYLF LQ++ D+ G+L C + Sbjct: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121 Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264 + LQ+ELG+ E + +++ R++PNQ + +E I ++ G+SPA++++ L+ Sbjct: 122 VSHILQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLD 179 Query: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL- 323 A+ L+MYG+ H +G + L + G+L+ G KI F W KI K+ FK+ Sbjct: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239 Query: 324 ------TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNR 377 LV+ +D T F + S CK WK VE+HAFFRL SK + Sbjct: 240 IKLHANILVLCKD---------TLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKP-K 289 Query: 378 SDFIRLGSRFRFSGRTEYQATHGSRLRRTST--FERKPSKRYPSRRHSTFKASNPVIAAQ 435 + GS FR+SGRT+ Q R R + FER K YPS+ H S+P + + Sbjct: 290 TLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFER---KHYPSQYHERQCRSSPDLLSD 346 Query: 436 LCSKTNPEVHNYQPQYHPN---IHPSQPRWHPHSPN--VRPSFQDDRSHWKASA 484 + + Y Y+ N +H S+P N + +F + H K A Sbjct: 347 VSKQVEDLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEA 400 >gi|223941876 protein tyrosine phosphatase, non-receptor type 3 isoform 1 [Homo sapiens] Length = 913 Score = 191 bits (485), Expect = 1e-48 Identities = 112/348 (32%), Positives = 180/348 (51%), Gaps = 11/348 (3%) Query: 82 KATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLD-SAQVAHWL 140 ++ + C + LDG + + K GQ L D + HL + E +YFGLQ D S WL Sbjct: 26 RSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWL 85 Query: 141 DHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYET 200 + +K I+KQ+K G LHFRV+++ +PN L++E TR+L+ LQL+ DI G+L CP + Sbjct: 86 EASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNS 145 Query: 201 AVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAEL 260 AV LA+ +Q+ G+ H P +S+ FIP+Q E + ++ G ++AE Sbjct: 146 AVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAES 205 Query: 261 SYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKK 320 Y+N A+ L+ YGV++H R + +G+ G+ ++ + W I K+ FK+ Sbjct: 206 CYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKR 265 Query: 321 SKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL-RTPGNSKSNRSD 379 K + + Q +EH F + + R+CK+LWK VEHH FF+ + K+ S Sbjct: 266 KK--FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQ 323 Query: 380 FIRLGSR-FRFSGRTEY------QATHGSRLRRTSTFERKPSKRYPSR 420 + +GSR + S +Y +RR+ + E +K PSR Sbjct: 324 YWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSR 371 >gi|223941879 protein tyrosine phosphatase, non-receptor type 3 isoform 2 [Homo sapiens] Length = 868 Score = 190 bits (482), Expect = 3e-48 Identities = 114/380 (30%), Positives = 185/380 (48%), Gaps = 24/380 (6%) Query: 82 KATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLD-SAQVAHWL 140 ++ + C + LDG + + K GQ L D + HL + E +YFGLQ D S WL Sbjct: 26 RSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWL 85 Query: 141 DHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYET 200 + +K I+KQ+K G LHFRV+++ +PN L++E TR+L+ LQL+ DI G+L CP + Sbjct: 86 EASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNS 145 Query: 201 AVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAEL 260 AV LA+ +Q+ G+ H P +S+ FIP+Q E + ++ G ++AE Sbjct: 146 AVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAES 205 Query: 261 SYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKK 320 Y+N A+ L+ YGV++H R + +G+ G+ ++ + W I K+ FK+ Sbjct: 206 CYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKR 265 Query: 321 SKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL-RTPGNSKSNRSD 379 K + + Q +EH F + + R+CK+LWK VEHH FF+ + K+ S Sbjct: 266 KK--FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQ 323 Query: 380 FIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIAAQLCSK 439 + +GSR +T +R P R+ R+ A N ++ Sbjct: 324 YWTMGSR--------------------NTKKRSPRLRHEIRKPRHSSADNLANEMTYITE 363 Query: 440 TNPEVHNYQPQYHPNIHPSQ 459 T + Y+ P S+ Sbjct: 364 TEDVFYTYKGSLAPQDSDSE 383 >gi|150418005 protein tyrosine phosphatase, non-receptor type 21 [Homo sapiens] Length = 1174 Score = 130 bits (327), Expect = 3e-30 Identities = 83/297 (27%), Positives = 145/297 (48%), Gaps = 17/297 (5%) Query: 80 AAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHW 139 ++K+ L R+ LL+ V L + GQ+ + + L+L E YF L + + W Sbjct: 18 SSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRW 77 Query: 140 LDHAKPIKKQM-KIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPY 198 +D KP+KKQ+ K ++F V +Y + L++E TRY + LQL+ DIL G + C Sbjct: 78 VDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTL 137 Query: 199 ETAVELAALCLQAELGECELPEHTPELVSEFRFIP---NQTEAMEFDIFQR----WKECR 251 E A++LA L +QA+ G+ + E + + + +F P Q E + + Q+ ++ R Sbjct: 138 EQAIQLAGLAVQADFGDFDQYE-SQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYR 196 Query: 252 GKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILI-FEGANKIGLFFW 310 G + AE+ Y+ + + ++ YG + + + G + S+G GI + + +F W Sbjct: 197 GLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRW 256 Query: 311 PKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL 367 I M KS L + +E T F+ + T K++W+ V H F+RL Sbjct: 257 HDIANMSHNKSFFALELA-------NKEETIQFQTEDMETAKYIWRLCVARHKFYRL 306 >gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [Homo sapiens] Length = 1187 Score = 126 bits (317), Expect = 4e-29 Identities = 86/314 (27%), Positives = 149/314 (47%), Gaps = 23/314 (7%) Query: 81 AKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWL 140 +K R+ LLD + L + GQ+ + + L+L ET YFGL FL +Q A W+ Sbjct: 17 SKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWV 76 Query: 141 DHAKPIKKQM-KIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYE 199 + KP+KK + K L F V +Y + L++E TRY + LQ++ D+L G+L+C + Sbjct: 77 ELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLD 136 Query: 200 TAVELAALCLQAELGECELPEHTPELVSEFRFIPNQ-------TEAMEFDIFQRWKECRG 252 + LA L +QA+ G+ + + + + E+ P E + + Q K G Sbjct: 137 QVIRLAGLAVQADFGDYNQFD-SQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSG 195 Query: 253 KSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIG----LF 308 PA+AEL Y+N+ + L+ +G ++ V+ G LG+ GI + N+IG ++ Sbjct: 196 ILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFV---RNRIGRQAVIY 252 Query: 309 FWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLR 368 W + + KS + + ++ +E T +F D K++ + H F++ Sbjct: 253 RWNDMGNITHNKSTILVELI-------NKEETALFHTDDIENAKYISRLFATRHKFYKQN 305 Query: 369 TPGNSKSNRSDFIR 382 +SN IR Sbjct: 306 KICTEQSNSPPPIR 319 >gi|38788243 myosin regulatory light chain interacting protein [Homo sapiens] Length = 445 Score = 125 bits (314), Expect = 9e-29 Identities = 88/289 (30%), Positives = 138/289 (47%), Gaps = 14/289 (4%) Query: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144 + C V D + V++ A G+D +Q+ L ++E DYFGLQF S + WL+ Sbjct: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRN 60 Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204 I +QM Y L RVK++ EP+ + +E TR++F L ++ +L+G L C E AVEL Sbjct: 61 RISQQMDGLAPYRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVEL 119 Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264 +AL Q + G+ ++T + E + A I + KE G S A AE L Sbjct: 120 SALLAQTKFGDYN--QNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQ 177 Query: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILI----FEGANKIGLFFWPKITKMDFKK 320 +E YG++ H VR +G + +G+ P GI I F N+I +P + Sbjct: 178 IVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIA---YPVVQMATQSG 234 Query: 321 SKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRT 369 + L V ++ +F++ S R L++ E HAF+R T Sbjct: 235 KNVYLTVTKESG----NSIVLLFKMISTRAASGLYRAITETHAFYRCDT 279 >gi|4506467 radixin [Homo sapiens] Length = 583 Score = 116 bits (291), Expect = 4e-26 Identities = 91/298 (30%), Positives = 146/298 (48%), Gaps = 23/298 (7%) Query: 88 RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147 RV +D E+ + + G+ LFDQ+V + L E +FGLQ++DS + WL K + Sbjct: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVT 66 Query: 148 KQ-MKIGPAYALHFRVKYYSSEPNN-LREEFTRYLFVLQLRHDILSGKLKCPYETAVELA 205 +Q +K FR K++ + + L +E T+ LF LQ++ IL+ ++ CP ETAV LA Sbjct: 67 QQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLA 126 Query: 206 ALCLQAELGECELPEHTPELVSEFRFIPNQ-------TEAMEFDIFQRW-KECRGKSPAQ 257 + +QA+ G+ H P ++ R +P + T+ + Q W +E RG Sbjct: 127 SYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLRED 186 Query: 258 AELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGAN----KIGLFFWPKI 313 + + YL A+ LEMYGV+ ++ + G E LG+ G+ I+E + KIG F W +I Sbjct: 187 SMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIG-FPWSEI 245 Query: 314 TKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKH-LWKCAVEHHAFFRLRTP 370 + F K + ++ ++ FVF R K L C H + R R P Sbjct: 246 RNISFNDKKFVIKPID------KKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKP 297 >gi|223941882 protein tyrosine phosphatase, non-receptor type 3 isoform 3 [Homo sapiens] Length = 782 Score = 113 bits (283), Expect = 4e-25 Identities = 70/241 (29%), Positives = 116/241 (48%), Gaps = 10/241 (4%) Query: 188 DILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRW 247 DI G+L CP +AV LA+ +Q+ G+ H P +S+ FIP+Q E + Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61 Query: 248 KECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGL 307 ++ G ++AE Y+N A+ L+ YGV++H R + +G+ G+ ++ Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121 Query: 308 FFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL 367 + W I K+ FK+ K + + Q +EH F + + R+CK+LWK VEHH FF+ Sbjct: 122 YPWVNILKISFKRKK--FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQA 179 Query: 368 -RTPGNSKSNRSDFIRLGSR-FRFSGRTEY------QATHGSRLRRTSTFERKPSKRYPS 419 + K+ S + +GSR + S +Y +RR+ + E +K PS Sbjct: 180 KKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPS 239 Query: 420 R 420 R Sbjct: 240 R 240 >gi|161702986 ezrin [Homo sapiens] Length = 586 Score = 113 bits (282), Expect = 5e-25 Identities = 92/299 (30%), Positives = 139/299 (46%), Gaps = 25/299 (8%) Query: 88 RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147 RV +D E+ + + G+ LFDQ+V + L E YFGL ++D+ WL K + Sbjct: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS 66 Query: 148 KQ--MKIGPAYALHFRVKYYSSE-PNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204 Q K P FR K+Y + L ++ T+ LF LQ++ ILS ++ CP ETAV L Sbjct: 67 AQEVRKENPLQ-FKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLL 125 Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQ-------TEAMEFDIFQRW-KECRGKSPA 256 + +QA+ G+ H +S R IP + T D Q W E RG Sbjct: 126 GSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKD 185 Query: 257 QAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGAN----KIGLFFWPK 312 A L YL A+ LEMYG++ ++ + G + LG+ G+ I+E + KIG F W + Sbjct: 186 NAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIG-FPWSE 244 Query: 313 ITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWK-CAVEHHAFFRLRTP 370 I + F K + ++ ++ FVF R K + + C H + R R P Sbjct: 245 IRNISFNDKKFVIKPID------KKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKP 297 >gi|21614499 ezrin [Homo sapiens] Length = 586 Score = 113 bits (282), Expect = 5e-25 Identities = 92/299 (30%), Positives = 139/299 (46%), Gaps = 25/299 (8%) Query: 88 RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147 RV +D E+ + + G+ LFDQ+V + L E YFGL ++D+ WL K + Sbjct: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS 66 Query: 148 KQ--MKIGPAYALHFRVKYYSSE-PNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204 Q K P FR K+Y + L ++ T+ LF LQ++ ILS ++ CP ETAV L Sbjct: 67 AQEVRKENPLQ-FKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLL 125 Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQ-------TEAMEFDIFQRW-KECRGKSPA 256 + +QA+ G+ H +S R IP + T D Q W E RG Sbjct: 126 GSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKD 185 Query: 257 QAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGAN----KIGLFFWPK 312 A L YL A+ LEMYG++ ++ + G + LG+ G+ I+E + KIG F W + Sbjct: 186 NAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIG-FPWSE 244 Query: 313 ITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWK-CAVEHHAFFRLRTP 370 I + F K + ++ ++ FVF R K + + C H + R R P Sbjct: 245 IRNISFNDKKFVIKPID------KKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKP 297 >gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] Length = 590 Score = 112 bits (281), Expect = 6e-25 Identities = 83/302 (27%), Positives = 141/302 (46%), Gaps = 19/302 (6%) Query: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143 T R+ +D E+ + KG+DLFD + L L ET +FGLQ+ VA Sbjct: 21 TFTVRIVTMDA-EMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDK 79 Query: 144 KPIKKQMKIGPAYALHFRVKYY-SSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAV 202 K + + HF K+Y + L +E T++LF LQ++ IL K+ CP E +V Sbjct: 80 KVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASV 139 Query: 203 ELAALCLQAELGECELPEHTPELVSEFRFIPNQT--------EAMEFDIFQRWKECRGKS 254 LA+ +QA+ G+ + H +++ +P + E E I + E RG++ Sbjct: 140 LLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRA 199 Query: 255 PAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIG---LFFWP 311 +AE+ YL A+ LEMYGV+ +R + G E LG+ G+ I++ N++ F W Sbjct: 200 RDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWN 259 Query: 312 KITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPG 371 +I + + + T+ ++ ++ F F R K + + + +H F R Sbjct: 260 EIRNISYSDKEFTIKPLD------KKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKA 313 Query: 372 NS 373 +S Sbjct: 314 DS 315 >gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] Length = 590 Score = 112 bits (281), Expect = 6e-25 Identities = 83/302 (27%), Positives = 141/302 (46%), Gaps = 19/302 (6%) Query: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143 T R+ +D E+ + KG+DLFD + L L ET +FGLQ+ VA Sbjct: 21 TFTVRIVTMDA-EMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDK 79 Query: 144 KPIKKQMKIGPAYALHFRVKYY-SSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAV 202 K + + HF K+Y + L +E T++LF LQ++ IL K+ CP E +V Sbjct: 80 KVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASV 139 Query: 203 ELAALCLQAELGECELPEHTPELVSEFRFIPNQT--------EAMEFDIFQRWKECRGKS 254 LA+ +QA+ G+ + H +++ +P + E E I + E RG++ Sbjct: 140 LLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRA 199 Query: 255 PAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIG---LFFWP 311 +AE+ YL A+ LEMYGV+ +R + G E LG+ G+ I++ N++ F W Sbjct: 200 RDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWN 259 Query: 312 KITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPG 371 +I + + + T+ ++ ++ F F R K + + + +H F R Sbjct: 260 EIRNISYSDKEFTIKPLD------KKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKA 313 Query: 372 NS 373 +S Sbjct: 314 DS 315 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.136 0.422 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,101,421 Number of Sequences: 37866 Number of extensions: 1046031 Number of successful extensions: 6506 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 99 Number of HSP's successfully gapped in prelim test: 113 Number of HSP's that attempted gapping in prelim test: 5711 Number of HSP's gapped (non-prelim): 649 length of query: 518 length of database: 18,247,518 effective HSP length: 107 effective length of query: 411 effective length of database: 14,195,856 effective search space: 5834496816 effective search space used: 5834496816 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.