Guide to the Human Genome
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Search of human proteins with 110624794

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110624794 erythrocyte membrane protein band 4.1 like 4B
isoform 1 [Homo sapiens]
         (518 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo...  1073   0.0  
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo...   970   0.0  
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s...   553   e-157
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]        279   4e-75
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor...   273   3e-73
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor...   273   3e-73
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ...   273   3e-73
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s...   269   5e-72
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform...   265   1e-70
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform...   265   1e-70
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho...   261   1e-69
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi...   258   1e-68
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis...   258   1e-68
gi|117500790 FERM domain containing 3 [Homo sapiens]                  231   1e-60
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]         227   2e-59
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform...   211   1e-54
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi...   210   2e-54
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...   201   1e-51
gi|34916000 FERM domain containing 7 [Homo sapiens]                   193   4e-49
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i...   191   1e-48
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i...   190   3e-48
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ...   130   3e-30
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [...   126   4e-29
gi|38788243 myosin regulatory light chain interacting protein [H...   125   9e-29
gi|4506467 radixin [Homo sapiens]                                     116   4e-26
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i...   113   4e-25
gi|161702986 ezrin [Homo sapiens]                                     113   5e-25
gi|21614499 ezrin [Homo sapiens]                                      113   5e-25
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]                  112   6e-25
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]                  112   6e-25

>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
           1 [Homo sapiens]
          Length = 518

 Score = 1073 bits (2774), Expect = 0.0
 Identities = 518/518 (100%), Positives = 518/518 (100%)

Query: 1   MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60
           MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP
Sbjct: 1   MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60

Query: 61  AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120
           AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL
Sbjct: 61  AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120

Query: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180
           VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL
Sbjct: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180

Query: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240
           FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME
Sbjct: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240

Query: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300
           FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE
Sbjct: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300

Query: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360
           GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE
Sbjct: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360

Query: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420
           HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR
Sbjct: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420

Query: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVRPSFQDDRSHW 480
           RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVRPSFQDDRSHW
Sbjct: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVRPSFQDDRSHW 480

Query: 481 KASASGDDSHFDYVHDQNQKNLGGMQSMMYRDKLMTAL 518
           KASASGDDSHFDYVHDQNQKNLGGMQSMMYRDKLMTAL
Sbjct: 481 KASASGDDSHFDYVHDQNQKNLGGMQSMMYRDKLMTAL 518


>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
           2 [Homo sapiens]
          Length = 900

 Score =  970 bits (2507), Expect = 0.0
 Identities = 469/469 (100%), Positives = 469/469 (100%)

Query: 1   MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60
           MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP
Sbjct: 1   MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60

Query: 61  AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120
           AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL
Sbjct: 61  AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120

Query: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180
           VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL
Sbjct: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180

Query: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240
           FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME
Sbjct: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240

Query: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300
           FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE
Sbjct: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300

Query: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360
           GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE
Sbjct: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360

Query: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420
           HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR
Sbjct: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420

Query: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNV 469
           RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNV
Sbjct: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNV 469


>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
           sapiens]
          Length = 733

 Score =  553 bits (1426), Expect = e-157
 Identities = 289/474 (60%), Positives = 340/474 (71%), Gaps = 58/474 (12%)

Query: 1   MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFP 60
           ML F RRT GRRSM+++A     R A                                  
Sbjct: 1   MLSFFRRTLGRRSMRKHAEKERLREAQR-------------------------------- 28

Query: 61  AGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDL 120
                     AA HI AAG +K+ + CRV LLDGT+VSVDLPK AKGQ+LFDQI+YHLDL
Sbjct: 29  ----------AATHIPAAGDSKSIITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDL 78

Query: 121 VETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180
           +E+DYFGL+F+DSAQVAHWLD  K IKKQ+KIG  Y LH RVK+YSSEPNNLREE TRYL
Sbjct: 79  IESDYFGLRFMDSAQVAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYL 138

Query: 181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAME 240
           FVLQL+ DILSGKL CP++TAV+LAA  LQAELG+ +L EH+PELVSEFRF+P QTE ME
Sbjct: 139 FVLQLKQDILSGKLDCPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEME 198

Query: 241 FDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFE 300
             IF++WKE RG++PAQAE +YLNKAKWLEMYGVDMHVV+ RDG +YSLGLTPTG+L+FE
Sbjct: 199 LAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFE 258

Query: 301 GANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVE 360
           G  KIGLFFWPKIT++DFKK+KLTLVVVEDDDQG+EQEHTFVFRLD  + CKHLWKCAVE
Sbjct: 259 GDTKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVE 318

Query: 361 HHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSR 420
           HHAFFRLR P    S+RS FIRLGSRFR+SG+TEYQ T  ++ RR+++FER+PSKRY SR
Sbjct: 319 HHAFFRLRGPVQKSSHRSGFIRLGSRFRYSGKTEYQTTKTNKARRSTSFERRPSKRY-SR 377

Query: 421 RHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWH-----PHSPNV 469
           R    KA         C+ T PE  +         + SQ  W      P SP++
Sbjct: 378 RTLQMKA---------CA-TKPEELSVHNNVSTQSNGSQQAWGMRSALPVSPSI 421


>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
          Length = 686

 Score =  279 bits (714), Expect = 4e-75
 Identities = 151/377 (40%), Positives = 222/377 (58%), Gaps = 17/377 (4%)

Query: 80  AAKATLYCRVFLLDGTEVSVD-----LPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSA 134
           A     YC V LLD +++++      + K  KG  + D + +H++LVE DYFGL++ D +
Sbjct: 6   AVPEEFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRS 65

Query: 135 QVAHWLDHAKPI---KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILS 191
              +WLD AK +   K+ +  GP Y L+F +K+Y+ +P  L+EE TRY F LQ++ D+L 
Sbjct: 66  HQTYWLDPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQ 125

Query: 192 GKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECR 251
           G+L CP  TA +L A  +Q+ELG+ +  +HT   VSE+RF+P+Q E +E  I +  K   
Sbjct: 126 GRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLM 185

Query: 252 GKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWP 311
           G+ P++AEL+YL  AK LEMYGVD+H V G +  EY LGLTP G+++++   ++G +FWP
Sbjct: 186 GQIPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWP 245

Query: 312 KITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL-RTP 370
           +ITK+ FK+++  L V+  D      E +F F   S   CKHLWKC+VEHH FFR+    
Sbjct: 246 RITKVHFKETQFELRVLGKDC----NETSFFFEARSKTACKHLWKCSVEHHTFFRMPENE 301

Query: 371 GNSKSNR-SDFIRLGSRFRFSGRTEYQATHGSRL---RRTSTFERKPSKRYPSRRHSTFK 426
            NS S + S F  +  + R+SGRT  Q +    +   R      R  SK YP R   T  
Sbjct: 302 SNSLSRKLSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYPKRIAQTQP 361

Query: 427 ASNPVIAAQLCSKTNPE 443
           A +  I+    +  N E
Sbjct: 362 AESNSISRITANMENGE 378


>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score =  273 bits (698), Expect = 3e-73
 Identities = 150/335 (44%), Positives = 207/335 (61%), Gaps = 7/335 (2%)

Query: 84  TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
           T+ C+V LLDGTE S DL KHAKGQ LFD++  HL+L+E DYFGL F +S +  +WLD A
Sbjct: 217 TVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPA 276

Query: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203
           K IK+Q++  P +   F VK+Y  +P+ L E+ TRY   LQLR DI SG+L C + T   
Sbjct: 277 KEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHAL 335

Query: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
           L +  LQAELG+ +  EH    +SEF+F P QT+ +E  + +  K  RG SPAQA+  +L
Sbjct: 336 LGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFL 395

Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
             AK L MYGVD+H  +  +G +  LG+   G+LI++   +I  F WPKI K+ +K+S  
Sbjct: 396 ENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF 455

Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
            + V   + +  + E T  F+L + R  K LWK  VEHH F+RL +P   +  ++ F+ L
Sbjct: 456 YIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSP--EQPPKAKFLTL 511

Query: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
           GS+FR+SGRT+ Q    S L  R    FER  SKR
Sbjct: 512 GSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR 546


>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score =  273 bits (698), Expect = 3e-73
 Identities = 150/335 (44%), Positives = 207/335 (61%), Gaps = 7/335 (2%)

Query: 84  TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
           T+ C+V LLDGTE S DL KHAKGQ LFD++  HL+L+E DYFGL F +S +  +WLD A
Sbjct: 217 TVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPA 276

Query: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203
           K IK+Q++  P +   F VK+Y  +P+ L E+ TRY   LQLR DI SG+L C + T   
Sbjct: 277 KEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHAL 335

Query: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
           L +  LQAELG+ +  EH    +SEF+F P QT+ +E  + +  K  RG SPAQA+  +L
Sbjct: 336 LGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFL 395

Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
             AK L MYGVD+H  +  +G +  LG+   G+LI++   +I  F WPKI K+ +K+S  
Sbjct: 396 ENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF 455

Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
            + V   + +  + E T  F+L + R  K LWK  VEHH F+RL +P   +  ++ F+ L
Sbjct: 456 YIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSP--EQPPKAKFLTL 511

Query: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
           GS+FR+SGRT+ Q    S L  R    FER  SKR
Sbjct: 512 GSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR 546


>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
           [Homo sapiens]
          Length = 1005

 Score =  273 bits (698), Expect = 3e-73
 Identities = 150/335 (44%), Positives = 207/335 (61%), Gaps = 7/335 (2%)

Query: 84  TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
           T+ C+V LLDGTE S DL KHAKGQ LFD++  HL+L+E DYFGL F +S +  +WLD A
Sbjct: 217 TVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPA 276

Query: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203
           K IK+Q++  P +   F VK+Y  +P+ L E+ TRY   LQLR DI SG+L C + T   
Sbjct: 277 KEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHAL 335

Query: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
           L +  LQAELG+ +  EH    +SEF+F P QT+ +E  + +  K  RG SPAQA+  +L
Sbjct: 336 LGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFL 395

Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
             AK L MYGVD+H  +  +G +  LG+   G+LI++   +I  F WPKI K+ +K+S  
Sbjct: 396 ENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF 455

Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
            + V   + +  + E T  F+L + R  K LWK  VEHH F+RL +P   +  ++ F+ L
Sbjct: 456 YIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSP--EQPPKAKFLTL 511

Query: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
           GS+FR+SGRT+ Q    S L  R    FER  SKR
Sbjct: 512 GSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR 546


>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
           sapiens]
          Length = 1087

 Score =  269 bits (687), Expect = 5e-72
 Identities = 142/340 (41%), Positives = 207/340 (60%), Gaps = 8/340 (2%)

Query: 84  TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
           ++ C+V LLDG+E + D+ K ++GQ LFD++  HL+L+E DYFGL + D+    +WLD A
Sbjct: 109 SMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPA 168

Query: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203
           K IKKQ++ G A+   F VK+Y  +P  L E+ TRY   LQLR DI+SG+L C + T   
Sbjct: 169 KEIKKQVRSG-AWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLAL 227

Query: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
           L +  +Q+ELG+ +  E   + +SEFRF PN T+ +E  + +  K  RG +PA+AE+ +L
Sbjct: 228 LGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFL 287

Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
             AK L MYGVD+H  +  +G E  LG+  +G+LI+    +I  F WPK+ K+ +K++  
Sbjct: 288 ENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNF 347

Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
            + +   + +  + E T  F+L + R  K LWK  VEHH FFRL  P   ++    F+ L
Sbjct: 348 YIKIRPGEFE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLP---EAPPKKFLTL 402

Query: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421
           GS+FR+SGRT+ Q    S L  R    FER  SKRY   R
Sbjct: 403 GSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSR 442


>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
           [Homo sapiens]
          Length = 779

 Score =  265 bits (676), Expect = 1e-70
 Identities = 142/337 (42%), Positives = 199/337 (59%), Gaps = 8/337 (2%)

Query: 87  CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146
           CRV LLD +E   ++ KH +GQ LFD +  HL+L+E DYFGL F D+    +WLD +K I
Sbjct: 37  CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 96

Query: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206
           KKQ++  P +   F VK+Y  +P  L E+ TRY   LQLR DI++G+L C + T   L +
Sbjct: 97  KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 155

Query: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKA 266
             +QAELG+ +  EH    VSE RF PNQT  +E  I +  K  RG +P +AE+ +L  A
Sbjct: 156 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 215

Query: 267 KWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLV 326
           K L MYGVD+H  +  +G +  LG+   G+LI+    +I  F WPKI K+ +K+S   + 
Sbjct: 216 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 275

Query: 327 VVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSR 386
           +   + +  + E T  F+L + R+ K LWK  +EHH FFRL +P   +     F+ +GS+
Sbjct: 276 IRPGEYE--QFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSP---EPPPKGFLVMGSK 330

Query: 387 FRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421
           FR+SGRT+ Q    S L  R    FER  SKRY   R
Sbjct: 331 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 367


>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
           [Homo sapiens]
          Length = 881

 Score =  265 bits (676), Expect = 1e-70
 Identities = 142/337 (42%), Positives = 199/337 (59%), Gaps = 8/337 (2%)

Query: 87  CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146
           CRV LLD +E   ++ KH +GQ LFD +  HL+L+E DYFGL F D+    +WLD +K I
Sbjct: 99  CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 158

Query: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206
           KKQ++  P +   F VK+Y  +P  L E+ TRY   LQLR DI++G+L C + T   L +
Sbjct: 159 KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 217

Query: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKA 266
             +QAELG+ +  EH    VSE RF PNQT  +E  I +  K  RG +P +AE+ +L  A
Sbjct: 218 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 277

Query: 267 KWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLV 326
           K L MYGVD+H  +  +G +  LG+   G+LI+    +I  F WPKI K+ +K+S   + 
Sbjct: 278 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 337

Query: 327 VVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSR 386
           +   + +  + E T  F+L + R+ K LWK  +EHH FFRL +P   +     F+ +GS+
Sbjct: 338 IRPGEYE--QFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSP---EPPPKGFLVMGSK 392

Query: 387 FRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421
           FR+SGRT+ Q    S L  R    FER  SKRY   R
Sbjct: 393 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 429


>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
           sapiens]
          Length = 926

 Score =  261 bits (666), Expect = 1e-69
 Identities = 143/357 (40%), Positives = 211/357 (59%), Gaps = 10/357 (2%)

Query: 67  LTGGAAVHISAAGAAK----ATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVE 122
           L  G   ++ A+  A+      + C + LLD T  +  + KH +GQ L D +  HLDL E
Sbjct: 7   LPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTE 66

Query: 123 TDYFGLQFLD-SAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLF 181
            DYFGLQ  D S     WLD  KPI+KQ+K G  Y+L+FRVK++ S+PN L+EE+TRY +
Sbjct: 67  QDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQY 126

Query: 182 VLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEF 241
            LQ++ DIL+G+L CP  TA  LA+  +Q+ELG+ +  E+    +S++ FIPNQ +  E 
Sbjct: 127 FLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEK 186

Query: 242 DIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEG 301
           +I +  ++  G SPA+AE +YLN A+ LE+YGV+ H  R +   E  +G+   GILI++ 
Sbjct: 187 EIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKN 246

Query: 302 ANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEH 361
             ++  F W KI K+ FK  +  + + ++  + RE      F + + R CK+LWK  VEH
Sbjct: 247 RVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRET--LLGFNMVNYRACKNLWKACVEH 304

Query: 362 HAFFRLRTPGNSKSN-RSDFIRLGSRFRFSGRTEYQATH--GSRLRRTSTFERKPSK 415
           H FFRL  P   + N  + +  LGS+FR+ GRTE Q+      +  +   F R PSK
Sbjct: 305 HTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSK 361


>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 2 [Homo sapiens]
          Length = 641

 Score =  258 bits (658), Expect = 1e-68
 Identities = 138/334 (41%), Positives = 199/334 (59%), Gaps = 7/334 (2%)

Query: 85  LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
           ++C+V LLD T     + KHAKGQDL  ++  HL+L+E DYFGL   D+A    WLD AK
Sbjct: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60

Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
            IKKQ++ G  +   F VK+Y  +P  L E+ TRY   LQLR DI++G+L C + T   L
Sbjct: 61  EIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119

Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
            +  +Q+ELG+ +   H  + VS+F+  PNQT+ +E  + +  K  R  +PAQA+L +L 
Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179

Query: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLT 324
            AK L MYGVD+H  +  +G +  LG+  +G+L+++   +I  F WPK+ K+ +K+S   
Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239

Query: 325 LVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLG 384
           + +   + +  + E T  F+L S R  K LWK  VEHH FFRL +       +S F+ LG
Sbjct: 240 IKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTIPKSKFLALG 295

Query: 385 SRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
           S+FR+SGRT+ Q    S L  R    FER  SKR
Sbjct: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 329


>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
           RH-linked) isoform 3 [Homo sapiens]
          Length = 588

 Score =  258 bits (658), Expect = 1e-68
 Identities = 138/334 (41%), Positives = 199/334 (59%), Gaps = 7/334 (2%)

Query: 85  LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
           ++C+V LLD T     + KHAKGQDL  ++  HL+L+E DYFGL   D+A    WLD AK
Sbjct: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60

Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
            IKKQ++ G  +   F VK+Y  +P  L E+ TRY   LQLR DI++G+L C + T   L
Sbjct: 61  EIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119

Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
            +  +Q+ELG+ +   H  + VS+F+  PNQT+ +E  + +  K  R  +PAQA+L +L 
Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179

Query: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLT 324
            AK L MYGVD+H  +  +G +  LG+  +G+L+++   +I  F WPK+ K+ +K+S   
Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239

Query: 325 LVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLG 384
           + +   + +  + E T  F+L S R  K LWK  VEHH FFRL +       +S F+ LG
Sbjct: 240 IKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTIPKSKFLALG 295

Query: 385 SRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
           S+FR+SGRT+ Q    S L  R    FER  SKR
Sbjct: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 329


>gi|117500790 FERM domain containing 3 [Homo sapiens]
          Length = 597

 Score =  231 bits (589), Expect = 1e-60
 Identities = 131/369 (35%), Positives = 195/369 (52%), Gaps = 14/369 (3%)

Query: 76  SAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQ 135
           S+  +    + C + LLD +E+S  + +  KGQ L D I  +  L+E DYFG++++D  +
Sbjct: 23  SSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEK 82

Query: 136 VAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLK 195
             HWL+  K I KQMK  P Y + FRVK+Y  EP  ++EE TRYL  LQ++ DI  G+L 
Sbjct: 83  QRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLL 142

Query: 196 CPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWK-ECRGKS 254
           C +  A  L A  +QAELG+ +  EH    +SEF   P Q++ +E  I +  K E RG+S
Sbjct: 143 CSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQS 202

Query: 255 PAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKIT 314
           P  AE + L KA  LE YGVD H  +   G    LG T  G ++F+G  +I L  WP + 
Sbjct: 203 PPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVC 262

Query: 315 KMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSK 374
           K+ F+     ++  +     +E++    F   +   CKHLWKC VE+ AF++       K
Sbjct: 263 KLKFEGKTFYVIGTQ-----KEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIK 317

Query: 375 S-NRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIA 433
           + + S     GSRFR+SG+   +    S     S  +R+P + +  R + T   S+  + 
Sbjct: 318 TVSSSKIFFKGSRFRYSGKVAKEVVEAS-----SKIQREPPEVH--RANITQSRSSHSLN 370

Query: 434 AQLCSKTNP 442
            QL     P
Sbjct: 371 KQLIINMEP 379


>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
          Length = 570

 Score =  227 bits (579), Expect = 2e-59
 Identities = 126/351 (35%), Positives = 197/351 (56%), Gaps = 11/351 (3%)

Query: 87  CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146
           C V LLD +E +  + + AKGQ LFD + +HL+L+E DYFG++F+D  +  HWL+  K +
Sbjct: 19  CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78

Query: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206
            KQ++  P + + FRVK+Y ++P  L+EE TRYL  LQ++ D+  G+L C    A  LAA
Sbjct: 79  VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138

Query: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWK-ECRGKSPAQAELSYLNK 265
             LQAE+G+ +  +H     S+F+F P  +E +E  I +  K E  G++PA +EL++L K
Sbjct: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198

Query: 266 AKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTL 325
           A+ LE YGVD H  +   G    L  TP G ++ +G  ++    W ++TK+ F+     L
Sbjct: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258

Query: 326 VVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKS-NRSDFIRLG 384
            V     Q  E++    +   +   CKHLWKC +E+ AF++L      ++ + S+    G
Sbjct: 259 YV----SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKG 314

Query: 385 SRFRFSGRTEYQATHGS-RLRRTSTFERK----PSKRYPSRRHSTFKASNP 430
           SRFR+SGR   +    S +++R      +    PS+  PS  H    +S P
Sbjct: 315 SRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVP 365


>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
           [Homo sapiens]
          Length = 1045

 Score =  211 bits (537), Expect = 1e-54
 Identities = 140/426 (32%), Positives = 225/426 (52%), Gaps = 18/426 (4%)

Query: 88  RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147
           ++ +LD T+ + ++P+ A G+ L D +  HL+LVE DYFGL+F D  ++  WLD  KPI 
Sbjct: 43  KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIV 102

Query: 148 KQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAAL 207
           KQ++      + F VK++  +   L+EE TRYLF LQ++ D+  G+L C   +A  L + 
Sbjct: 103 KQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISH 162

Query: 208 CLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKAK 267
            +Q+E+G+ +      E +++ ++IP Q +A+E  I +      G++PA+++   L  A+
Sbjct: 163 IVQSEIGDFD-EALDREHLAKNKYIPQQ-DALEDKIVEFHHNHIGQTPAESDFQLLEIAR 220

Query: 268 WLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVV 327
            LEMYG+ +H  + R+G + +L +  TGIL+F+G  KI  F W K+ K+ FK+ +  L+ 
Sbjct: 221 RLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRF-LIK 279

Query: 328 VEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSRF 387
           +  D     Q+ T  F + S   CK  WK  VEHHAFFRL      K     F R GS F
Sbjct: 280 LRPDANSAYQD-TLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSR-GSSF 337

Query: 388 RFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRRHSTFKAS-NPVIAAQLCSKT---- 440
           RFSGRT+ Q     +    +   FERK SK +  R  ++     N  +  Q    T    
Sbjct: 338 RFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTF 397

Query: 441 -----NPEVHNYQPQYHPNIHPSQPRWHPHSPNVRPSFQDDRSHWKASASGDDSHFDYVH 495
                +P   + +    P +   +P  HP SP  R S   ++    A+++  +   + V 
Sbjct: 398 GEGAESPGGQSCRRGKEPKVSAGEPGSHP-SPAPRRSPAGNKQADGAASAPTEEEEEVVK 456

Query: 496 DQNQKN 501
           D+ Q++
Sbjct: 457 DRTQQS 462


>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 1 [Homo sapiens]
          Length = 775

 Score =  210 bits (535), Expect = 2e-54
 Identities = 114/283 (40%), Positives = 166/283 (58%), Gaps = 7/283 (2%)

Query: 136 VAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLK 195
           V  WLD AK IKKQ++ G  +   F VK+Y  +P  L E+ TRY   LQLR DI++G+L 
Sbjct: 226 VETWLDSAKEIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLP 284

Query: 196 CPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSP 255
           C + T   L +  +Q+ELG+ +   H  + VS+F+  PNQT+ +E  + +  K  R  +P
Sbjct: 285 CSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTP 344

Query: 256 AQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITK 315
           AQA+L +L  AK L MYGVD+H  +  +G +  LG+  +G+L+++   +I  F WPK+ K
Sbjct: 345 AQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLK 404

Query: 316 MDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKS 375
           + +K+S   + +   + +  + E T  F+L S R  K LWK  VEHH FFRL +      
Sbjct: 405 ISYKRSSFFIKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTI 460

Query: 376 NRSDFIRLGSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
            +S F+ LGS+FR+SGRT+ Q    S L  R    FER  SKR
Sbjct: 461 PKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 503


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
           sapiens]
          Length = 1054

 Score =  201 bits (512), Expect = 1e-51
 Identities = 122/344 (35%), Positives = 191/344 (55%), Gaps = 10/344 (2%)

Query: 85  LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
           L+ RV LLD T    D+     GQ L  Q+   L+LVE DYFG++F ++     WL+  K
Sbjct: 44  LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMK 103

Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
           PI +Q++      L   VK++  +P  L+EE+TRYLF LQL+ D+L  +L C   TA  L
Sbjct: 104 PIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALL 163

Query: 205 AALCLQAELGECELPEHTPEL-VSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
            +  LQ+E+G+ +       L V+E  ++P Q   +E  I +  ++  G++PA+++   L
Sbjct: 164 TSHLLQSEIGDYDETLDREHLKVNE--YLPGQQHCLE-KILEFHQKHVGQTPAESDFQVL 220

Query: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
             A+ LEMYG+  H+   R+G +  L ++  G+L+F+G  KI  F W K+ K+ FK+ + 
Sbjct: 221 EIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRF 280

Query: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
            L+ +  +  G  Q+ T  F L S   CK+ WK  VE+H FFRL      K+ ++ F   
Sbjct: 281 -LIKLHPEVHGPYQD-TLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKA-KAVFFSR 337

Query: 384 GSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKA 427
           GS FR+SGRT+ Q        + S  +R P +R  S+ H++ +A
Sbjct: 338 GSSFRYSGRTQKQLVD---YFKDSGMKRIPYERRHSKTHTSVRA 378


>gi|34916000 FERM domain containing 7 [Homo sapiens]
          Length = 714

 Score =  193 bits (490), Expect = 4e-49
 Identities = 132/414 (31%), Positives = 206/414 (49%), Gaps = 29/414 (7%)

Query: 85  LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
           L+ +V  LD ++    + + + G+ LF+    HL+L E +YFGL+F   +    WL+  K
Sbjct: 2   LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61

Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
           PI KQ+K        F VK++  +P +LREE TRYLF LQ++ D+  G+L C       +
Sbjct: 62  PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121

Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
            +  LQ+ELG+    E   + +++ R++PNQ + +E  I    ++  G+SPA++++  L+
Sbjct: 122 VSHILQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLD 179

Query: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL- 323
            A+ L+MYG+  H     +G +  L +   G+L+  G  KI  F W KI K+ FK+    
Sbjct: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239

Query: 324 ------TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNR 377
                  LV+ +D         T  F + S   CK  WK  VE+HAFFRL     SK  +
Sbjct: 240 IKLHANILVLCKD---------TLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKP-K 289

Query: 378 SDFIRLGSRFRFSGRTEYQATHGSRLRRTST--FERKPSKRYPSRRHSTFKASNPVIAAQ 435
           +     GS FR+SGRT+ Q     R  R  +  FER   K YPS+ H     S+P + + 
Sbjct: 290 TLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFER---KHYPSQYHERQCRSSPDLLSD 346

Query: 436 LCSKTNPEVHNYQPQYHPN---IHPSQPRWHPHSPN--VRPSFQDDRSHWKASA 484
           +  +       Y   Y+ N   +H S+P       N  +  +F  +  H K  A
Sbjct: 347 VSKQVEDLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEA 400


>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
           isoform 1 [Homo sapiens]
          Length = 913

 Score =  191 bits (485), Expect = 1e-48
 Identities = 112/348 (32%), Positives = 180/348 (51%), Gaps = 11/348 (3%)

Query: 82  KATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLD-SAQVAHWL 140
           ++ + C +  LDG   +  + K   GQ L D +  HL + E +YFGLQ  D S     WL
Sbjct: 26  RSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWL 85

Query: 141 DHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYET 200
           + +K I+KQ+K G    LHFRV+++  +PN L++E TR+L+ LQL+ DI  G+L CP  +
Sbjct: 86  EASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNS 145

Query: 201 AVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAEL 260
           AV LA+  +Q+  G+     H P  +S+  FIP+Q E     +    ++  G   ++AE 
Sbjct: 146 AVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAES 205

Query: 261 SYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKK 320
            Y+N A+ L+ YGV++H  R     +  +G+   G+ ++        + W  I K+ FK+
Sbjct: 206 CYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKR 265

Query: 321 SKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL-RTPGNSKSNRSD 379
            K    + +   Q   +EH   F + + R+CK+LWK  VEHH FF+  +     K+  S 
Sbjct: 266 KK--FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQ 323

Query: 380 FIRLGSR-FRFSGRTEY------QATHGSRLRRTSTFERKPSKRYPSR 420
           +  +GSR  + S   +Y             +RR+ + E   +K  PSR
Sbjct: 324 YWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSR 371


>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
           isoform 2 [Homo sapiens]
          Length = 868

 Score =  190 bits (482), Expect = 3e-48
 Identities = 114/380 (30%), Positives = 185/380 (48%), Gaps = 24/380 (6%)

Query: 82  KATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLD-SAQVAHWL 140
           ++ + C +  LDG   +  + K   GQ L D +  HL + E +YFGLQ  D S     WL
Sbjct: 26  RSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWL 85

Query: 141 DHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYET 200
           + +K I+KQ+K G    LHFRV+++  +PN L++E TR+L+ LQL+ DI  G+L CP  +
Sbjct: 86  EASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNS 145

Query: 201 AVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAEL 260
           AV LA+  +Q+  G+     H P  +S+  FIP+Q E     +    ++  G   ++AE 
Sbjct: 146 AVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAES 205

Query: 261 SYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKK 320
            Y+N A+ L+ YGV++H  R     +  +G+   G+ ++        + W  I K+ FK+
Sbjct: 206 CYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKR 265

Query: 321 SKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL-RTPGNSKSNRSD 379
            K    + +   Q   +EH   F + + R+CK+LWK  VEHH FF+  +     K+  S 
Sbjct: 266 KK--FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQ 323

Query: 380 FIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIAAQLCSK 439
           +  +GSR                    +T +R P  R+  R+     A N        ++
Sbjct: 324 YWTMGSR--------------------NTKKRSPRLRHEIRKPRHSSADNLANEMTYITE 363

Query: 440 TNPEVHNYQPQYHPNIHPSQ 459
           T    + Y+    P    S+
Sbjct: 364 TEDVFYTYKGSLAPQDSDSE 383


>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
           [Homo sapiens]
          Length = 1174

 Score =  130 bits (327), Expect = 3e-30
 Identities = 83/297 (27%), Positives = 145/297 (48%), Gaps = 17/297 (5%)

Query: 80  AAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHW 139
           ++K+ L  R+ LL+   V   L   + GQ+  + +   L+L E  YF L + +      W
Sbjct: 18  SSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRW 77

Query: 140 LDHAKPIKKQM-KIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPY 198
           +D  KP+KKQ+ K      ++F V +Y    + L++E TRY + LQL+ DIL G + C  
Sbjct: 78  VDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTL 137

Query: 199 ETAVELAALCLQAELGECELPEHTPELVSEFRFIP---NQTEAMEFDIFQR----WKECR 251
           E A++LA L +QA+ G+ +  E + + + +F   P    Q E +  +  Q+     ++ R
Sbjct: 138 EQAIQLAGLAVQADFGDFDQYE-SQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYR 196

Query: 252 GKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILI-FEGANKIGLFFW 310
           G +   AE+ Y+ + + ++ YG + +  +   G + S+G    GI +  +      +F W
Sbjct: 197 GLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRW 256

Query: 311 PKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL 367
             I  M   KS   L +         +E T  F+ +   T K++W+  V  H F+RL
Sbjct: 257 HDIANMSHNKSFFALELA-------NKEETIQFQTEDMETAKYIWRLCVARHKFYRL 306


>gi|34328899 protein tyrosine phosphatase, non-receptor type 14
           [Homo sapiens]
          Length = 1187

 Score =  126 bits (317), Expect = 4e-29
 Identities = 86/314 (27%), Positives = 149/314 (47%), Gaps = 23/314 (7%)

Query: 81  AKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWL 140
           +K     R+ LLD   +   L   + GQ+  + +   L+L ET YFGL FL  +Q A W+
Sbjct: 17  SKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWV 76

Query: 141 DHAKPIKKQM-KIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYE 199
           +  KP+KK + K      L F V +Y    + L++E TRY + LQ++ D+L G+L+C  +
Sbjct: 77  ELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLD 136

Query: 200 TAVELAALCLQAELGECELPEHTPELVSEFRFIPNQ-------TEAMEFDIFQRWKECRG 252
             + LA L +QA+ G+    + + + + E+   P          E +   + Q  K   G
Sbjct: 137 QVIRLAGLAVQADFGDYNQFD-SQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSG 195

Query: 253 KSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIG----LF 308
             PA+AEL Y+N+ + L+ +G ++  V+   G    LG+   GI +    N+IG    ++
Sbjct: 196 ILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFV---RNRIGRQAVIY 252

Query: 309 FWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLR 368
            W  +  +   KS + + ++        +E T +F  D     K++ +     H F++  
Sbjct: 253 RWNDMGNITHNKSTILVELI-------NKEETALFHTDDIENAKYISRLFATRHKFYKQN 305

Query: 369 TPGNSKSNRSDFIR 382
                +SN    IR
Sbjct: 306 KICTEQSNSPPPIR 319


>gi|38788243 myosin regulatory light chain interacting protein [Homo
           sapiens]
          Length = 445

 Score =  125 bits (314), Expect = 9e-29
 Identities = 88/289 (30%), Positives = 138/289 (47%), Gaps = 14/289 (4%)

Query: 85  LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
           + C V   D   + V++   A G+D  +Q+   L ++E DYFGLQF  S   + WL+   
Sbjct: 1   MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRN 60

Query: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
            I +QM     Y L  RVK++  EP+ + +E TR++F L ++  +L+G L C  E AVEL
Sbjct: 61  RISQQMDGLAPYRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVEL 119

Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
           +AL  Q + G+    ++T +   E       + A    I  + KE  G S A AE   L 
Sbjct: 120 SALLAQTKFGDYN--QNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQ 177

Query: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILI----FEGANKIGLFFWPKITKMDFKK 320
               +E YG++ H VR  +G +  +G+ P GI I    F   N+I    +P +       
Sbjct: 178 IVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIA---YPVVQMATQSG 234

Query: 321 SKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRT 369
             + L V ++           +F++ S R    L++   E HAF+R  T
Sbjct: 235 KNVYLTVTKESG----NSIVLLFKMISTRAASGLYRAITETHAFYRCDT 279


>gi|4506467 radixin [Homo sapiens]
          Length = 583

 Score =  116 bits (291), Expect = 4e-26
 Identities = 91/298 (30%), Positives = 146/298 (48%), Gaps = 23/298 (7%)

Query: 88  RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147
           RV  +D  E+   +  +  G+ LFDQ+V  + L E  +FGLQ++DS   + WL   K + 
Sbjct: 8   RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVT 66

Query: 148 KQ-MKIGPAYALHFRVKYYSSEPNN-LREEFTRYLFVLQLRHDILSGKLKCPYETAVELA 205
           +Q +K        FR K++  + +  L +E T+ LF LQ++  IL+ ++ CP ETAV LA
Sbjct: 67  QQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLA 126

Query: 206 ALCLQAELGECELPEHTPELVSEFRFIPNQ-------TEAMEFDIFQRW-KECRGKSPAQ 257
           +  +QA+ G+     H P  ++  R +P +       T+    +  Q W +E RG     
Sbjct: 127 SYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLRED 186

Query: 258 AELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGAN----KIGLFFWPKI 313
           + + YL  A+ LEMYGV+   ++ + G E  LG+   G+ I+E  +    KIG F W +I
Sbjct: 187 SMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIG-FPWSEI 245

Query: 314 TKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKH-LWKCAVEHHAFFRLRTP 370
             + F   K  +  ++      ++   FVF     R  K  L  C   H  + R R P
Sbjct: 246 RNISFNDKKFVIKPID------KKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKP 297


>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
           isoform 3 [Homo sapiens]
          Length = 782

 Score =  113 bits (283), Expect = 4e-25
 Identities = 70/241 (29%), Positives = 116/241 (48%), Gaps = 10/241 (4%)

Query: 188 DILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRW 247
           DI  G+L CP  +AV LA+  +Q+  G+     H P  +S+  FIP+Q E     +    
Sbjct: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61

Query: 248 KECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGL 307
           ++  G   ++AE  Y+N A+ L+ YGV++H  R     +  +G+   G+ ++        
Sbjct: 62  EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121

Query: 308 FFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL 367
           + W  I K+ FK+ K    + +   Q   +EH   F + + R+CK+LWK  VEHH FF+ 
Sbjct: 122 YPWVNILKISFKRKK--FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQA 179

Query: 368 -RTPGNSKSNRSDFIRLGSR-FRFSGRTEY------QATHGSRLRRTSTFERKPSKRYPS 419
            +     K+  S +  +GSR  + S   +Y             +RR+ + E   +K  PS
Sbjct: 180 KKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPS 239

Query: 420 R 420
           R
Sbjct: 240 R 240


>gi|161702986 ezrin [Homo sapiens]
          Length = 586

 Score =  113 bits (282), Expect = 5e-25
 Identities = 92/299 (30%), Positives = 139/299 (46%), Gaps = 25/299 (8%)

Query: 88  RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147
           RV  +D  E+   +  +  G+ LFDQ+V  + L E  YFGL ++D+     WL   K + 
Sbjct: 8   RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS 66

Query: 148 KQ--MKIGPAYALHFRVKYYSSE-PNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
            Q   K  P     FR K+Y  +    L ++ T+ LF LQ++  ILS ++ CP ETAV L
Sbjct: 67  AQEVRKENPLQ-FKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLL 125

Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQ-------TEAMEFDIFQRW-KECRGKSPA 256
            +  +QA+ G+     H    +S  R IP +       T     D  Q W  E RG    
Sbjct: 126 GSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKD 185

Query: 257 QAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGAN----KIGLFFWPK 312
            A L YL  A+ LEMYG++   ++ + G +  LG+   G+ I+E  +    KIG F W +
Sbjct: 186 NAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIG-FPWSE 244

Query: 313 ITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWK-CAVEHHAFFRLRTP 370
           I  + F   K  +  ++      ++   FVF     R  K + + C   H  + R R P
Sbjct: 245 IRNISFNDKKFVIKPID------KKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKP 297


>gi|21614499 ezrin [Homo sapiens]
          Length = 586

 Score =  113 bits (282), Expect = 5e-25
 Identities = 92/299 (30%), Positives = 139/299 (46%), Gaps = 25/299 (8%)

Query: 88  RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147
           RV  +D  E+   +  +  G+ LFDQ+V  + L E  YFGL ++D+     WL   K + 
Sbjct: 8   RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS 66

Query: 148 KQ--MKIGPAYALHFRVKYYSSE-PNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
            Q   K  P     FR K+Y  +    L ++ T+ LF LQ++  ILS ++ CP ETAV L
Sbjct: 67  AQEVRKENPLQ-FKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLL 125

Query: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQ-------TEAMEFDIFQRW-KECRGKSPA 256
            +  +QA+ G+     H    +S  R IP +       T     D  Q W  E RG    
Sbjct: 126 GSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKD 185

Query: 257 QAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGAN----KIGLFFWPK 312
            A L YL  A+ LEMYG++   ++ + G +  LG+   G+ I+E  +    KIG F W +
Sbjct: 186 NAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIG-FPWSE 244

Query: 313 ITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWK-CAVEHHAFFRLRTP 370
           I  + F   K  +  ++      ++   FVF     R  K + + C   H  + R R P
Sbjct: 245 IRNISFNDKKFVIKPID------KKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKP 297


>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score =  112 bits (281), Expect = 6e-25
 Identities = 83/302 (27%), Positives = 141/302 (46%), Gaps = 19/302 (6%)

Query: 84  TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
           T   R+  +D  E+  +     KG+DLFD +   L L ET +FGLQ+     VA      
Sbjct: 21  TFTVRIVTMDA-EMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDK 79

Query: 144 KPIKKQMKIGPAYALHFRVKYY-SSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAV 202
           K +   +        HF  K+Y  +    L +E T++LF LQ++  IL  K+ CP E +V
Sbjct: 80  KVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASV 139

Query: 203 ELAALCLQAELGECELPEHTPELVSEFRFIPNQT--------EAMEFDIFQRWKECRGKS 254
            LA+  +QA+ G+ +   H    +++   +P +         E  E  I   + E RG++
Sbjct: 140 LLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRA 199

Query: 255 PAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIG---LFFWP 311
             +AE+ YL  A+ LEMYGV+   +R + G E  LG+   G+ I++  N++     F W 
Sbjct: 200 RDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWN 259

Query: 312 KITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPG 371
           +I  + +   + T+  ++      ++   F F     R  K + +  + +H  F  R   
Sbjct: 260 EIRNISYSDKEFTIKPLD------KKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKA 313

Query: 372 NS 373
           +S
Sbjct: 314 DS 315


>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score =  112 bits (281), Expect = 6e-25
 Identities = 83/302 (27%), Positives = 141/302 (46%), Gaps = 19/302 (6%)

Query: 84  TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
           T   R+  +D  E+  +     KG+DLFD +   L L ET +FGLQ+     VA      
Sbjct: 21  TFTVRIVTMDA-EMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDK 79

Query: 144 KPIKKQMKIGPAYALHFRVKYY-SSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAV 202
           K +   +        HF  K+Y  +    L +E T++LF LQ++  IL  K+ CP E +V
Sbjct: 80  KVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASV 139

Query: 203 ELAALCLQAELGECELPEHTPELVSEFRFIPNQT--------EAMEFDIFQRWKECRGKS 254
            LA+  +QA+ G+ +   H    +++   +P +         E  E  I   + E RG++
Sbjct: 140 LLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRA 199

Query: 255 PAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIG---LFFWP 311
             +AE+ YL  A+ LEMYGV+   +R + G E  LG+   G+ I++  N++     F W 
Sbjct: 200 RDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWN 259

Query: 312 KITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPG 371
           +I  + +   + T+  ++      ++   F F     R  K + +  + +H  F  R   
Sbjct: 260 EIRNISYSDKEFTIKPLD------KKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKA 313

Query: 372 NS 373
           +S
Sbjct: 314 DS 315


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,101,421
Number of Sequences: 37866
Number of extensions: 1046031
Number of successful extensions: 6506
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 99
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 5711
Number of HSP's gapped (non-prelim): 649
length of query: 518
length of database: 18,247,518
effective HSP length: 107
effective length of query: 411
effective length of database: 14,195,856
effective search space: 5834496816
effective search space used: 5834496816
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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