Search of human proteins with 167466252

Search of human proteins with 167466252

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
sapiens]
         (418 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ...   852   0.0  
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ...   847   0.0  
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       369   e-102
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         368   e-102
gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        355   6e-98
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          354   9e-98
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        322   5e-88
gi|33695155 hepsin [Homo sapiens]                                     198   7e-51
gi|4504481 hepsin [Homo sapiens]                                      198   7e-51
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           191   1e-48
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   187   1e-47
gi|11415040 matriptase [Homo sapiens]                                 184   1e-46
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   183   2e-46
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   183   2e-46
gi|148613878 acrosin precursor [Homo sapiens]                         180   2e-45
gi|4506153 prostasin preproprotein [Homo sapiens]                     179   4e-45
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         179   4e-45
gi|223942069 enterokinase precursor [Homo sapiens]                    177   1e-44
gi|4503627 coagulation factor XI precursor [Homo sapiens]             174   1e-43
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   174   2e-43
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   174   2e-43
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]      173   3e-43
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           172   5e-43
gi|205360905 testis-specific serine protease 1 [Homo sapiens]         169   6e-42
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          165   6e-41
gi|29244926 corin [Homo sapiens]                                      164   2e-40
gi|5803197 testisin isoform 1 [Homo sapiens]                          163   2e-40
gi|145275213 coagulation factor XII precursor [Homo sapiens]          162   4e-40
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             162   5e-40
gi|21614531 testisin isoform 2 [Homo sapiens]                         161   1e-39

>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
           sapiens]
          Length = 418

 Score =  852 bits (2202), Expect = 0.0
 Identities = 418/418 (100%), Positives = 418/418 (100%)

Query: 1   MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP 60
           MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP
Sbjct: 1   MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP 60

Query: 61  QINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMV 120
           QINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMV
Sbjct: 61  QINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMV 120

Query: 121 FQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGKRVV 180
           FQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGKRVV
Sbjct: 121 FQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGKRVV 180

Query: 181 PLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQWTV 240
           PLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQWTV
Sbjct: 181 PLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQWTV 240

Query: 241 SFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEASASF 300
           SFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEASASF
Sbjct: 241 SFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEASASF 300

Query: 301 QPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGI 360
           QPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGI
Sbjct: 301 QPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGI 360

Query: 361 YDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI 418
           YDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI
Sbjct: 361 YDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI 418


>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
           sapiens]
          Length = 421

 Score =  847 bits (2188), Expect = 0.0
 Identities = 418/421 (99%), Positives = 418/421 (99%), Gaps = 3/421 (0%)

Query: 1   MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP 60
           MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP
Sbjct: 1   MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP 60

Query: 61  QINNNFGQSNTYQLKDLRETTENLV---DEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDV 117
           QINNNFGQSNTYQLKDLRETTENLV   DEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDV
Sbjct: 61  QINNNFGQSNTYQLKDLRETTENLVSQVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDV 120

Query: 118 IMVFQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGK 177
           IMVFQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGK
Sbjct: 121 IMVFQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGK 180

Query: 178 RVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQ 237
           RVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQ
Sbjct: 181 RVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQ 240

Query: 238 WTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEAS 297
           WTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEAS
Sbjct: 241 WTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEAS 300

Query: 298 ASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYM 357
           ASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYM
Sbjct: 301 ASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYM 360

Query: 358 EGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTG 417
           EGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTG
Sbjct: 361 EGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTG 420

Query: 418 I 418
           I
Sbjct: 421 I 421


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  369 bits (946), Expect = e-102
 Identities = 181/423 (42%), Positives = 273/423 (64%), Gaps = 5/423 (1%)

Query: 1   MMYRTVGFGTRSRNL-KPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEY-YHGSFKIL 58
           MMYR      R R   +PW+I ++I +SL V+AV IGL VH++ ++QKK Y Y+ +    
Sbjct: 1   MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT 60

Query: 59  DPQINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVI 118
             ++   FG+  +    ++ +  E++V   F  S  ++ ++K+QV++ + ++ GV   ++
Sbjct: 61  TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML 120

Query: 119 MVFQFPSTEQRAVREKKIQSILNQKIRNLRALP-INASSVQVNAMSSSTGELTVQASCG- 176
           ++ +F STE     +K +Q +L++K+++    P ++  SV++  ++ +  +  +   CG 
Sbjct: 121 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPQSVKIKKINKTETDSYLNHCCGT 180

Query: 177 KRVVPLNVN-RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNP 235
           +R   L  + RI  G    +  WPWQASLQ+D  H+CGATLI+ TWLV+AAHCF  YKNP
Sbjct: 181 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP 240

Query: 236 HQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPE 295
            +WT SFG  I P  MKR +RR I+HEKY+  + +YDI++ ++SS V +++ + ++CLP+
Sbjct: 241 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD 300

Query: 296 ASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAG 355
           AS  FQP   + +TGFGAL   G SQN LR+A+V +I    C +PQ Y + I P M CAG
Sbjct: 301 ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG 360

Query: 356 YMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASK 415
            +EG  DAC+GDSGGPLV+ D +D WYL GIVSWGD C + +KPGVYT+VT  R+WI SK
Sbjct: 361 SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK 420

Query: 416 TGI 418
           TGI
Sbjct: 421 TGI 423


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  368 bits (945), Expect = e-102
 Identities = 181/423 (42%), Positives = 273/423 (64%), Gaps = 5/423 (1%)

Query: 1   MMYRTVGFGTRSRNL-KPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEY-YHGSFKIL 58
           MMYR      R R   +PW+I ++I +SL V+AV IGL VH++ ++QKK Y Y+ +    
Sbjct: 1   MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT 60

Query: 59  DPQINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVI 118
             ++   FG+  +    ++ +  E++V   F  S  ++ ++K+QV++ + ++ GV   ++
Sbjct: 61  TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML 120

Query: 119 MVFQFPSTEQRAVREKKIQSILNQKIRNLRALP-INASSVQVNAMSSSTGELTVQASCG- 176
           ++ +F STE     +K +Q +L++K+++    P ++  SV++  ++ +  +  +   CG 
Sbjct: 121 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGT 180

Query: 177 KRVVPLNVN-RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNP 235
           +R   L  + RI  G    +  WPWQASLQ+D  H+CGATLI+ TWLV+AAHCF  YKNP
Sbjct: 181 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP 240

Query: 236 HQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPE 295
            +WT SFG  I P  MKR +RR I+HEKY+  + +YDI++ ++SS V +++ + ++CLP+
Sbjct: 241 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD 300

Query: 296 ASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAG 355
           AS  FQP   + +TGFGAL   G SQN LR+A+V +I    C +PQ Y + I P M CAG
Sbjct: 301 ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG 360

Query: 356 YMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASK 415
            +EG  DAC+GDSGGPLV+ D +D WYL GIVSWGD C + +KPGVYT+VT  R+WI SK
Sbjct: 361 SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK 420

Query: 416 TGI 418
           TGI
Sbjct: 421 TGI 423


>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  355 bits (910), Expect = 6e-98
 Identities = 188/439 (42%), Positives = 268/439 (61%), Gaps = 22/439 (5%)

Query: 1   MMYRTVGFGTRS-------RNLKPWMIAVLIVLSLTVVAV---TIGLLVHFLVFDQKKEY 50
           MMY  V F           R  + W    L + +L +VA+    IG++ HF+V D K  Y
Sbjct: 1   MMYAPVEFSEAEFSRAEYQRKQQFWDSVRLALFTLAIVAIIGIAIGIVTHFVVEDDKSFY 60

Query: 51  YHGSFKILDPQINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEE 110
           Y  SFK+ + +   N+G  ++ +  +     E ++  IF  S+    +IK+ V++L+P+E
Sbjct: 61  YLASFKVTNIKYKENYGIRSSREFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDE 120

Query: 111 DGVKVDVIMVFQFPSTEQRAVREKKIQSILNQKIRNLR-ALPINASSVQVNAMSSSTGEL 169
            GV + ++++F++PST+     +KKI+  L Q ++  + +L IN  S ++  + S     
Sbjct: 121 QGVDILIVLIFRYPSTDSAEQIKKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKKMRN 180

Query: 170 TVQASCGKRVVPLNV--------NRIASG-VIAPKAAWPWQASLQY-DNIHQCGATLISN 219
            + + CG R+   N+         RI  G   A +  WPWQASLQ   + HQCGA+LISN
Sbjct: 181 LLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISN 240

Query: 220 TWLVTAAHCFQKYKNPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVS 279
           TWL+TAAHCF K K+P QW  +FG  I PP +KRNVR+ I+HE Y     E DIA+VQ+S
Sbjct: 241 TWLLTAAHCFWKNKDPTQWIATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLS 300

Query: 280 SRVTFSDDIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQ 339
           + V FS+ ++++CLP++S    P  +V +TGFG++   G  QN LR+ARV+ IS DVC +
Sbjct: 301 TGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNR 360

Query: 340 PQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKP 399
             VY   I PGM CAG+MEG  DAC+GDSGGPLV  D  D WY++GIVSWG +C    KP
Sbjct: 361 KDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLV-YDNHDIWYIVGIVSWGQSCALPKKP 419

Query: 400 GVYTQVTYYRNWIASKTGI 418
           GVYT+VT YR+WIASKTG+
Sbjct: 420 GVYTRVTKYRDWIASKTGM 438


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  354 bits (908), Expect = 9e-98
 Identities = 168/418 (40%), Positives = 250/418 (59%), Gaps = 1/418 (0%)

Query: 2   MYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDPQ 61
           MYR     + SR L P+++  ++V  + ++AVTI LLV+FL FDQK  +Y  SF++L+ +
Sbjct: 1   MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVE 60

Query: 62  INNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMVF 121
            N+      T + + L    E+L+ + F +S  +  +I+  V +L  +  GV+ DV+M F
Sbjct: 61  YNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKF 120

Query: 122 QFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTV-QASCGKRVV 180
           QF      A  + +I+S+L Q + N   L IN S+   +    +     + +   G  ++
Sbjct: 121 QFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLI 180

Query: 181 PLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQWTV 240
            L+  RI  G  A + +WPWQ SL+ +N H CG +LI+N W++TAAHCF+   NP  W  
Sbjct: 181 TLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIA 240

Query: 241 SFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEASASF 300
           + G     P ++  VR  +IH  Y+SA  E DIA+V++ + VTF+ DI  +CLP A+ + 
Sbjct: 241 TSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNI 300

Query: 301 QPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGI 360
            P  T ++TG+GA  Y G +  +LR+ +V+IIS+DVC  P  Y   I  GM CAG  +G 
Sbjct: 301 PPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGG 360

Query: 361 YDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI 418
            DAC+GDSGGPLV  D +  W+++GIVSWGD CG  DKPGVYT+VT Y +WI  +TGI
Sbjct: 361 VDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI 418


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  322 bits (824), Expect = 5e-88
 Identities = 171/423 (40%), Positives = 248/423 (58%), Gaps = 13/423 (3%)

Query: 2   MYRTVGFGTRSRNLKPWMIAVLIVLSLT-VVAVTIGLLVHFLVFDQKKEYYHGSFKILDP 60
           MYR    G  S+   P    + I L +  ++ VTIGLLVHFL  + K  YY G F I   
Sbjct: 1   MYR---HGISSQRSWPLWTTIFIFLGVAAILGVTIGLLVHFLAVE-KTYYYQGDFHISGV 56

Query: 61  QINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMV 120
             N+N   + +    +L +  E  +   F +S+  K Y+K++V++L P  +G  V + + 
Sbjct: 57  TYNDNCENAASQASTNLSKDIETKMLNAFQNSSIYKEYVKSEVIKLLPNANGSNVQLQLK 116

Query: 121 FQFPSTEQRAVREK---KIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGK 177
           F+FP  E  ++R K   K+  +L   + +  A+P   +S+++  +S +  E+     CG+
Sbjct: 117 FKFPPAEGVSMRTKIKAKLHQMLKNNMASWNAVP---ASIKLMEISKAASEMLTNNCCGR 173

Query: 178 RVVP--LNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNP 235
           +V    +  N+I +G  + + AWPWQAS+Q+   H CGA+LIS+ WL++AAHCF K  N 
Sbjct: 174 QVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKKNNS 233

Query: 236 HQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPE 295
             WTV+FG  +N P M R V+  I HE Y S     DIA+VQ++  V+F++ IR+ICLPE
Sbjct: 234 KDWTVNFGIVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLPE 293

Query: 296 ASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAG 355
           A      N  V +TG+G LY  G     L+E  +KII + +C     Y   +   M CAG
Sbjct: 294 AKMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAG 353

Query: 356 YMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASK 415
           +M G  DAC+ DSGGPL   D ++ W+L+GIVSWGD CG+K+KPGVYT+VT YRNWI SK
Sbjct: 354 FMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWITSK 413

Query: 416 TGI 418
           TG+
Sbjct: 414 TGL 416


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  198 bits (504), Expect = 7e-51
 Identities = 107/250 (42%), Positives = 142/250 (56%), Gaps = 14/250 (5%)

Query: 175 CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCF-QKYK 233
           CG+R +P  V+RI  G       WPWQ SL+YD  H CG +L+S  W++TAAHCF ++ +
Sbjct: 153 CGRRKLP--VDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNR 210

Query: 234 NPHQWTVSFGT--KINPPLMKRNVRRFIIHEKY------RSAAREYDIAVVQVSSRVTFS 285
              +W V  G   + +P  ++  V+  + H  Y       S     DIA+V +SS +  +
Sbjct: 211 VLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270

Query: 286 DDIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGN 345
           + I+ +CLP A  +        +TG+G   Y G+    L+EARV IIS+DVC     YGN
Sbjct: 271 EYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGN 330

Query: 346 DIKPGMFCAGYMEGIYDACRGDSGGPLVTRD---LKDTWYLIGIVSWGDNCGQKDKPGVY 402
            IKP MFCAGY EG  DAC+GDSGGP V  D       W L GIVSWG  C    KPGVY
Sbjct: 331 QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVY 390

Query: 403 TQVTYYRNWI 412
           T+V+ +R WI
Sbjct: 391 TKVSDFREWI 400


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  198 bits (504), Expect = 7e-51
 Identities = 107/250 (42%), Positives = 142/250 (56%), Gaps = 14/250 (5%)

Query: 175 CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCF-QKYK 233
           CG+R +P  V+RI  G       WPWQ SL+YD  H CG +L+S  W++TAAHCF ++ +
Sbjct: 153 CGRRKLP--VDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNR 210

Query: 234 NPHQWTVSFGT--KINPPLMKRNVRRFIIHEKY------RSAAREYDIAVVQVSSRVTFS 285
              +W V  G   + +P  ++  V+  + H  Y       S     DIA+V +SS +  +
Sbjct: 211 VLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270

Query: 286 DDIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGN 345
           + I+ +CLP A  +        +TG+G   Y G+    L+EARV IIS+DVC     YGN
Sbjct: 271 EYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGN 330

Query: 346 DIKPGMFCAGYMEGIYDACRGDSGGPLVTRD---LKDTWYLIGIVSWGDNCGQKDKPGVY 402
            IKP MFCAGY EG  DAC+GDSGGP V  D       W L GIVSWG  C    KPGVY
Sbjct: 331 QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVY 390

Query: 403 TQVTYYRNWI 412
           T+V+ +R WI
Sbjct: 391 TKVSDFREWI 400


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  191 bits (485), Expect = 1e-48
 Identities = 97/234 (41%), Positives = 138/234 (58%), Gaps = 8/234 (3%)

Query: 185 NRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQK--YKNPHQWTVSF 242
           +RI  G ++ +  WPWQASLQ    H CG  LI++ W++TAAHCFQ+    +   WTV  
Sbjct: 575 SRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFL 634

Query: 243 GTKIN----PPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEASA 298
           G        P  +   V R ++H  +   + +YD+A++Q+   V  S  +R +CLP  S 
Sbjct: 635 GKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSH 694

Query: 299 SFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYME 358
            F+P L   ITG+GAL  GG   N L++  V++I  D+C +  VY   + P M CAGY +
Sbjct: 695 FFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLCSE--VYRYQVTPRMLCAGYRK 752

Query: 359 GIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWI 412
           G  DAC+GDSGGPLV + L   W+L G+VSWG  CG+ +  GVYT++T   +WI
Sbjct: 753 GKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWI 806


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  187 bits (476), Expect = 1e-47
 Identities = 135/417 (32%), Positives = 216/417 (51%), Gaps = 37/417 (8%)

Query: 15  LKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYY-HGSFKILDPQINNNFGQSNTYQ 73
           LK + I V+ +++L ++A+ IGL +HF   D   +Y    SFK ++  I    G S+   
Sbjct: 46  LKFFPIIVIGIIAL-ILALAIGLGIHF---DCSGKYRCRSSFKCIE-LIARCDGVSDCKD 100

Query: 74  LKD----LRETTENLVDEIFIDSAWK-------KNYIKNQVVRLTPEEDGVKVDVIMVFQ 122
            +D    +R   +N V ++F  ++WK       K +  N           V  D + V  
Sbjct: 101 GEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRV-- 158

Query: 123 FPSTEQRAVREK--KIQSIL-NQKIRNLRALPINASSVQVNAMSSSTGELTVQAS-CGKR 178
             S+ +   RE+   I  +L + K+  L        SV V    +S   +T+Q + CG R
Sbjct: 159 --SSLEGQFREEFVSIDHLLPDDKVTALH------HSVYVREGCASGHVVTLQCTACGHR 210

Query: 179 VVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQW 238
                 +RI  G ++  + WPWQASLQ+   H CG ++I+  W++TAAHC      P  W
Sbjct: 211 RG--YSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSW 268

Query: 239 TVSFG--TKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEA 296
           T+  G  + ++ P     V + + H KY+      DIA+++++  +TF++ I+ +CLP +
Sbjct: 269 TIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNS 328

Query: 297 SASFQPNLTVHITGFGALYYG-GESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAG 355
             +F        +G+GA   G G++   L  A V +IS+ +C    VYG  I P M CAG
Sbjct: 329 EENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAG 388

Query: 356 YMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWI 412
           Y+ G  D+C+GDSGGPLV ++ +  W L+G  S+G  C + +KPGVYT+VT + +WI
Sbjct: 389 YLTGGVDSCQGDSGGPLVCQE-RRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 444


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  184 bits (468), Expect = 1e-46
 Identities = 95/265 (35%), Positives = 142/265 (53%), Gaps = 14/265 (5%)

Query: 165 STGELTVQASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQ-YDNIHQCGATLISNTWLV 223
           S G       CG R       R+  G  A +  WPWQ SL      H CGA+LIS  WLV
Sbjct: 594 SDGSDEKDCDCGLRSFTRQA-RVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLV 652

Query: 224 TAAHCFQ-----KYKNPHQWTVSFGT-----KINPPLMKRNVRRFIIHEKYRSAAREYDI 273
           +AAHC+      +Y +P QWT   G      +  P + +R ++R I H  +     +YDI
Sbjct: 653 SAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDI 712

Query: 274 AVVQVSSRVTFSDDIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIIS 333
           A++++     +S  +R ICLP+AS  F     + +TG+G   YGG     L++  +++I+
Sbjct: 713 ALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVIN 772

Query: 334 DDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNC 393
              C+   +    I P M C G++ G  D+C+GDSGGPL + +     +  G+VSWGD C
Sbjct: 773 QTTCEN--LLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGC 830

Query: 394 GQKDKPGVYTQVTYYRNWIASKTGI 418
            Q++KPGVYT++  +R+WI   TG+
Sbjct: 831 AQRNKPGVYTRLPLFRDWIKENTGV 855


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  183 bits (465), Expect = 2e-46
 Identities = 94/244 (38%), Positives = 133/244 (54%), Gaps = 7/244 (2%)

Query: 174 SCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQK-Y 232
           +CG  +     +RI  G  A   AWPWQ SL   N+H CG ++I+  W+VTAAHC +K  
Sbjct: 280 ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPL 339

Query: 233 KNPHQWTVSFGTKINPPLM----KRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDI 288
            NP  WT +F   +    M       V + I H  Y S  +  DIA++++   +TF+D +
Sbjct: 340 NNPWHWT-AFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLV 398

Query: 289 RQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIK 348
           + +CLP      QP     I+G+GA    G++   L  A+V +I    C    VY N I 
Sbjct: 399 KPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLIT 458

Query: 349 PGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYY 408
           P M CAG+++G  D+C+GDSGGPLVT    + W+LIG  SWG  C +  +PGVY  V  +
Sbjct: 459 PAMICAGFLQGNVDSCQGDSGGPLVT-SKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 517

Query: 409 RNWI 412
            +WI
Sbjct: 518 TDWI 521


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  183 bits (465), Expect = 2e-46
 Identities = 94/244 (38%), Positives = 133/244 (54%), Gaps = 7/244 (2%)

Query: 174 SCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQK-Y 232
           +CG  +     +RI  G  A   AWPWQ SL   N+H CG ++I+  W+VTAAHC +K  
Sbjct: 243 ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPL 302

Query: 233 KNPHQWTVSFGTKINPPLM----KRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDI 288
            NP  WT +F   +    M       V + I H  Y S  +  DIA++++   +TF+D +
Sbjct: 303 NNPWHWT-AFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLV 361

Query: 289 RQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIK 348
           + +CLP      QP     I+G+GA    G++   L  A+V +I    C    VY N I 
Sbjct: 362 KPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLIT 421

Query: 349 PGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYY 408
           P M CAG+++G  D+C+GDSGGPLVT    + W+LIG  SWG  C +  +PGVY  V  +
Sbjct: 422 PAMICAGFLQGNVDSCQGDSGGPLVT-SKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 480

Query: 409 RNWI 412
            +WI
Sbjct: 481 TDWI 484


>gi|148613878 acrosin precursor [Homo sapiens]
          Length = 421

 Score =  180 bits (456), Expect = 2e-45
 Identities = 102/267 (38%), Positives = 139/267 (52%), Gaps = 19/267 (7%)

Query: 170 TVQASCGKRVV--PLNVNRIASGVIAPKAAWPWQASLQY-----DNIHQCGATLISNTWL 222
           T    CG R    P    RI  G  A   AWPW  SLQ         H CG +L+++ W+
Sbjct: 24  TCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWV 83

Query: 223 VTAAHCFQKYKNPHQWTVSFGTK---------INPPLMKRNVRRFIIHEKYRSAAREYDI 273
           +TAAHCF    N H W + FG K         +  PL +R V + IIHEKY SA    DI
Sbjct: 84  LTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDI 143

Query: 274 AVVQVSSRVTFSDDIRQICLPEASASF-QPNLTVHITGFGALYYGGESQND-LREARVKI 331
           A+V+++  ++    I   CLP   A   + + +  + G+G +       +  L EARV +
Sbjct: 144 ALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDL 203

Query: 332 ISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWY-LIGIVSWG 390
           I  D+C   Q Y   ++P   CAGY  G  D C+GDSGGPL+ +D K++ Y ++GI SWG
Sbjct: 204 IDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWG 263

Query: 391 DNCGQKDKPGVYTQVTYYRNWIASKTG 417
             C +  +PG+YT    Y NWIASK G
Sbjct: 264 VGCARAKRPGIYTATWPYLNWIASKIG 290


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  179 bits (454), Expect = 4e-45
 Identities = 105/268 (39%), Positives = 144/268 (53%), Gaps = 21/268 (7%)

Query: 162 MSSSTGELTVQASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTW 221
           + S TG    +A CG  V P    RI  G  A    WPWQ S+ Y+ +H CG +L+S  W
Sbjct: 24  LRSGTGAEGAEAPCG--VAPQA--RITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQW 79

Query: 222 LVTAAHCFQKYKNPHQWTVSFGT----KINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQ 277
           +++AAHCF    +   + V  G       +       ++  I H  Y     + DIA++Q
Sbjct: 80  VLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQ 139

Query: 278 VSSRVTFSDDIRQICLPEASASFQPNLTVHITGFG--ALYYGGESQNDLREARVKIISDD 335
           +S  +TFS  IR ICLP A+ASF   L   +TG+G  A      +   L++  V +IS +
Sbjct: 140 LSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRE 199

Query: 336 VCKQPQVYGNDIKP--------GMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIV 387
            C    +Y  D KP         M CAGY+EG  DAC+GDSGGPL +  ++  WYL GIV
Sbjct: 200 TCN--CLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPL-SCPVEGLWYLTGIV 256

Query: 388 SWGDNCGQKDKPGVYTQVTYYRNWIASK 415
           SWGD CG +++PGVYT  + Y +WI SK
Sbjct: 257 SWGDACGARNRPGVYTLASSYASWIQSK 284


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  179 bits (454), Expect = 4e-45
 Identities = 102/252 (40%), Positives = 138/252 (54%), Gaps = 9/252 (3%)

Query: 169 LTVQAS-CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAH 227
           +++Q S CG R +     RI  G +A  + WPWQ SL +   H CG TLI   W++TAAH
Sbjct: 310 ISLQCSHCGLRAM---TGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAH 366

Query: 228 CF--QKYKNPHQWTVSFGTKINPPLMK-RNVRRFIIHEKYRSAAREYDIAVVQVSSRVTF 284
           CF   + K    W V  GT     L +  ++   II+  Y     +YDIA++++S  +T 
Sbjct: 367 CFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTL 426

Query: 285 SDDIRQICLPEASASFQPNLTVHITGFGALYYGGESQND-LREARVKIISDDVCKQPQVY 343
           S  I   CLP    +F  N T  ITGFG      +  +  LRE +V +I    C    VY
Sbjct: 427 SAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVY 486

Query: 344 GNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYT 403
            + + P M CAG + G  D+C+GDSGGPLV  +  + WYL G+ SWG  CGQ++KPGVYT
Sbjct: 487 DSYLTPRMMCAGDLRGGRDSCQGDSGGPLVC-EQNNRWYLAGVTSWGTGCGQRNKPGVYT 545

Query: 404 QVTYYRNWIASK 415
           +VT    WI SK
Sbjct: 546 KVTEVLPWIYSK 557


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  177 bits (450), Expect = 1e-44
 Identities = 91/248 (36%), Positives = 145/248 (58%), Gaps = 9/248 (3%)

Query: 174  SCGKRVVPLNVN-RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHC-FQK 231
            SCGK++   ++  +I  G  A + AWPW   L Y     CGA+L+S+ WLV+AAHC + +
Sbjct: 771  SCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGR 830

Query: 232  YKNPHQWTVSFGTKI-----NPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSD 286
               P +WT   G  +     +P  + R +   +I+  Y    ++ DIA++ +  +V ++D
Sbjct: 831  NLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTD 890

Query: 287  DIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGND 346
             I+ ICLPE +  F P     I G+G + Y G + N L+EA V ++S++ C+Q Q+   +
Sbjct: 891  YIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQ-QMPEYN 949

Query: 347  IKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVT 406
            I   M CAGY EG  D+C+GDSGGPL+ ++  + W+L G+ S+G  C   ++PGVY +V+
Sbjct: 950  ITENMICAGYEEGGIDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALPNRPGVYARVS 1008

Query: 407  YYRNWIAS 414
             +  WI S
Sbjct: 1009 RFTEWIQS 1016



 Score = 38.5 bits (88), Expect = 0.011
 Identities = 41/167 (24%), Positives = 69/167 (41%), Gaps = 8/167 (4%)

Query: 19  MIAVLIVLSLTVVAV---TIGLLVHFLVFDQKKEYYHGSFKILDP-QINNNFGQSNTYQL 74
           + A+L+VL   ++AV   TI          Q  E    +FKI      N N     +   
Sbjct: 24  LFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEA-RATFKITSGVTYNPNLQDKLSVDF 82

Query: 75  KDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMVFQFPSTEQRAVREK 134
           K L    + ++DEIF+ S  K  Y  ++V++    E+G  + V  +F         V+E+
Sbjct: 83  KVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQF---ENGSIIVVFDLFFAQWVSDENVKEE 139

Query: 135 KIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGKRVVP 181
            IQ +   K   L    I+ +SV +    ++T  L    +     +P
Sbjct: 140 LIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNVSIECLP 186


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  174 bits (441), Expect = 1e-43
 Identities = 92/250 (36%), Positives = 142/250 (56%), Gaps = 15/250 (6%)

Query: 175 CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNI---HQCGATLISNTWLVTAAHCFQK 231
           C  ++ P    RI  G  + +  WPWQ +L   +    H CG ++I N W++TAAHCF  
Sbjct: 380 CTTKIKP----RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYG 435

Query: 232 YKNPHQWTVSFGTKINPPLMKRN-----VRRFIIHEKYRSAAREYDIAVVQVSSRVTFSD 286
            ++P    V  G  +N   +K +     V+  IIH++Y+ A   YDIA++++ + V ++D
Sbjct: 436 VESPKILRVYSGI-LNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTD 494

Query: 287 DIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGND 346
             R ICLP             +TG+G      + QN L++A++ +++++ C Q +  G+ 
Sbjct: 495 SQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEEC-QKRYRGHK 553

Query: 347 IKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVT 406
           I   M CAGY EG  DAC+GDSGGPL  +   + W+L+GI SWG+ C Q+++PGVYT V 
Sbjct: 554 ITHKMICAGYREGGKDACKGDSGGPLSCKH-NEVWHLVGITSWGEGCAQRERPGVYTNVV 612

Query: 407 YYRNWIASKT 416
            Y +WI  KT
Sbjct: 613 EYVDWILEKT 622


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  174 bits (440), Expect = 2e-43
 Identities = 91/240 (37%), Positives = 130/240 (54%), Gaps = 6/240 (2%)

Query: 174 SCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYK 233
           +CGK    L   R+  G  A   +WPWQ S+QYD  H CG +++   W++TAAHCF+K+ 
Sbjct: 190 ACGKS---LKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHT 246

Query: 234 NPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICL 293
           +   W V  G+          V + II E      ++ DIA++++   +TFS  +R ICL
Sbjct: 247 DVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICL 306

Query: 294 PEASASFQPNLTVHITGFG-ALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMF 352
           P       P   + I G+G     GG+  + L +A V++I    C     Y  ++   M 
Sbjct: 307 PFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMM 366

Query: 353 CAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWI 412
           CAG  EG  D C+GDSGGPL+ +   D W+++GIVSWG  CG    PGVYT+V+ Y NWI
Sbjct: 367 CAGIPEGGVDTCQGDSGGPLMYQ--SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 424


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  174 bits (440), Expect = 2e-43
 Identities = 91/240 (37%), Positives = 130/240 (54%), Gaps = 6/240 (2%)

Query: 174 SCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYK 233
           +CGK    L   R+  G  A   +WPWQ S+QYD  H CG +++   W++TAAHCF+K+ 
Sbjct: 195 ACGKS---LKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHT 251

Query: 234 NPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICL 293
           +   W V  G+          V + II E      ++ DIA++++   +TFS  +R ICL
Sbjct: 252 DVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICL 311

Query: 294 PEASASFQPNLTVHITGFG-ALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMF 352
           P       P   + I G+G     GG+  + L +A V++I    C     Y  ++   M 
Sbjct: 312 PFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMM 371

Query: 353 CAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWI 412
           CAG  EG  D C+GDSGGPL+ +   D W+++GIVSWG  CG    PGVYT+V+ Y NWI
Sbjct: 372 CAGIPEGGVDTCQGDSGGPLMYQ--SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429


>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
          Length = 321

 Score =  173 bits (438), Expect = 3e-43
 Identities = 100/249 (40%), Positives = 136/249 (54%), Gaps = 10/249 (4%)

Query: 170 TVQASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCF 229
           T+Q  CG+  V     RI  G  AP  AWPWQASL+   +H CG +L+S  W++TAAHCF
Sbjct: 21  TLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCF 80

Query: 230 QKYKNPHQWTVSFG-TKINPPLMKRNVRRFIIHEK-YRSAAREYDIAVVQVSSRVTFSDD 287
               N   + V  G  +I        VR+ I+H           DIA+V++S  VT S  
Sbjct: 81  SGSLNSSDYQVHLGELEITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSR 140

Query: 288 IRQICLPEASASFQPNLTVHITGFGALYYGG--ESQNDLREARVKIISDDVCKQ--PQVY 343
           I  +CLPEAS  F P +   +TG+G    G        LRE +V ++  + C++  P   
Sbjct: 141 ILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPG 200

Query: 344 GNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYT 403
           G+ ++P M CA    G  DAC+ DSGGPLV + +   W   GIVSWG+ CG+ ++PGVYT
Sbjct: 201 GSILQPDMLCA---RGPGDACQDDSGGPLVCQ-VNGAWVQAGIVSWGEGCGRPNRPGVYT 256

Query: 404 QVTYYRNWI 412
           +V  Y NWI
Sbjct: 257 RVPAYVNWI 265


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  172 bits (436), Expect = 5e-43
 Identities = 89/257 (34%), Positives = 143/257 (55%), Gaps = 7/257 (2%)

Query: 165 STGELTVQASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVT 224
           S G       CG +       RI  G+ A    +PWQASL+ +  H CGA +I+  WLV+
Sbjct: 181 SDGSDEAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVS 240

Query: 225 AAHCFQKYKNPHQWTVSFGTKI----NPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSS 280
           AAHCF ++++P +W    G           ++  V + + H  Y +   ++D+AV++++S
Sbjct: 241 AAHCFNEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTS 300

Query: 281 RVTFSDDIRQICLPEASASFQPNLTVHITGFGALYYGGESQND-LREARVKIISDDVCKQ 339
            + F   I+ +CLP A+  F P+    I+G+G L      + + L++A V+++   +C  
Sbjct: 301 PLPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS 360

Query: 340 PQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKP 399
             +YG+ +   M CAGY++G  D+C+GDSGGPLV  +    ++L GIVSWG  C +  +P
Sbjct: 361 --LYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRP 418

Query: 400 GVYTQVTYYRNWIASKT 416
           GVY +VT  R+WI   T
Sbjct: 419 GVYARVTRLRDWILEAT 435



 Score =  171 bits (434), Expect = 9e-43
 Identities = 90/241 (37%), Positives = 127/241 (52%), Gaps = 7/241 (2%)

Query: 175  CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNI-HQCGATLISNTWLVTAAHCFQKYK 233
            CG  + P  + RI  G  A +  WPWQ SL      H+CGA L++  WL++AAHCF  Y 
Sbjct: 817  CG--LAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYG 874

Query: 234  NPHQWTVSFGTKI--NPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQI 291
            +P QW    GT            V R   H  Y     +YD+A+++++  V  S  +R I
Sbjct: 875  DPKQWAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPI 934

Query: 292  CLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGM 351
            CLPE +          ITG+G++  GG     L++A V+++S+  C++   Y   I   M
Sbjct: 935  CLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRR--FYPVQISSRM 992

Query: 352  FCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNW 411
             CAG+ +G  D+C GD+GGPL  R+    W L G+ SWG  CG+   PGVYT+V   R W
Sbjct: 993  LCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGW 1052

Query: 412  I 412
            I
Sbjct: 1053 I 1053



 Score =  162 bits (410), Expect = 5e-40
 Identities = 89/243 (36%), Positives = 130/243 (53%), Gaps = 8/243 (3%)

Query: 175 CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYK- 233
           CG R       R+  G  A     PWQ SL+  + H CGAT++ + WL++AAHCF   K 
Sbjct: 492 CGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKV 551

Query: 234 ---NPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQ 290
                H  T S       P+ K  +RR ++H  Y     ++D+AV++++S + F+  I+ 
Sbjct: 552 EQVRAHLGTASLLGLGGSPV-KIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQP 610

Query: 291 ICLPEASASFQPNLTVHITGFGALYYGGESQNDL-REARVKIISDDVCKQPQVYGNDIKP 349
           +CLP A   F       I+G+G    G  ++ +L ++A V II    C    +Y   +  
Sbjct: 611 VCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV--LYNFSLTD 668

Query: 350 GMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYR 409
            M CAG++EG  D+C+GDSGGPL   +    +YL GIVSWG  C Q  KPGVYT++T  +
Sbjct: 669 RMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLK 728

Query: 410 NWI 412
            WI
Sbjct: 729 GWI 731


>gi|205360905 testis-specific serine protease 1 [Homo sapiens]
          Length = 318

 Score =  169 bits (427), Expect = 6e-42
 Identities = 96/256 (37%), Positives = 146/256 (57%), Gaps = 21/256 (8%)

Query: 172 QASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQK 231
           + +CG R +   V   A GV + +  WPWQASL+    H+CG +L+S  W+++AAHCFQK
Sbjct: 43  EEACGHREIHALV---AGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQK 99

Query: 232 YKNPHQWTVSFGTKINPPL--------MKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVT 283
           +  P +WTV  G   + P          +  V+  I++       R  DIA+++++S VT
Sbjct: 100 HYYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRN-DIALLRLASSVT 158

Query: 284 FSDDIRQICLPEASASFQPNLTVHITGFGALYYGG---ESQNDLREARVKIISDDVC--- 337
           ++  I+ IC+  ++ +F       +TG+G +   G       +LREA+V I+++  C   
Sbjct: 159 YNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYL 218

Query: 338 -KQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQK 396
            +QP    + I   MFCAG  +G  D C+GDSGGPLV  D    WY +GIVSWG +CGQ 
Sbjct: 219 FEQPS-SRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVC-DKDGLWYQVGIVSWGMDCGQP 276

Query: 397 DKPGVYTQVTYYRNWI 412
           ++PGVYT ++ Y +WI
Sbjct: 277 NRPGVYTNISVYFHWI 292


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  165 bits (418), Expect = 6e-41
 Identities = 87/246 (35%), Positives = 130/246 (52%), Gaps = 10/246 (4%)

Query: 173 ASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKY 232
           + CG R  PL  +RI  G       WPWQAS+     H CG ++++  W+VTAAHC   +
Sbjct: 207 SECGAR--PL-ASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSF 263

Query: 233 KNPH--QWTVSFGTKINPPLMKRN---VRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDD 287
           +      W V  G   +  +       V R I H  Y +   +YD+A++++ + + FSD 
Sbjct: 264 RLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDT 323

Query: 288 IRQICLPEASASFQPNLTVHITGFGALYYGGESQND-LREARVKIISDDVCKQPQVYGND 346
           +  +CLP     F       ++G+G  +      +D L++  V + S  +C    VY   
Sbjct: 324 VGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGA 383

Query: 347 IKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVT 406
           + P M CAGY++G  DAC+GDSGGPLV  D  DTW L+G+VSWG  C + + PGVY +V 
Sbjct: 384 LTPRMLCAGYLDGRADACQGDSGGPLVCPD-GDTWRLVGVVSWGRGCAEPNHPGVYAKVA 442

Query: 407 YYRNWI 412
            + +WI
Sbjct: 443 EFLDWI 448


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  164 bits (414), Expect = 2e-40
 Identities = 97/272 (35%), Positives = 140/272 (51%), Gaps = 12/272 (4%)

Query: 147  LRALPINASSVQVNAMSSSTGELTVQASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQY 206
            L  L +N  S +  +  S    L  +  CG+R       RI  G  +    WPWQ SLQ 
Sbjct: 765  LHELLVNGQSCESRSKISL---LCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQS 821

Query: 207  D-NIHQCGATLISNTWLVTAAHCFQKYKNPHQWTVSFG-TKINPP---LMKRNVRRFIIH 261
            + + H CG  LI+  W++T AHCF+  +N   W V  G   ++ P   +  R V+  I+H
Sbjct: 822  EPSGHICGCVLIAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILH 881

Query: 262  EKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEASASFQPNLTVHITGFGALYYGGESQ 321
             +Y  A  +YDI++V++S  ++ +  +R +CLP      +P+   +ITG+G  + G +  
Sbjct: 882  PRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWG--HMGNKMP 939

Query: 322  NDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTW 381
              L+E  V+IIS + C Q       I   M CAGY  G  D+C GDSGGPLV       W
Sbjct: 940  FKLQEGEVRIISLEHC-QSYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRW 998

Query: 382  YLIGIVSWGDNCGQKD-KPGVYTQVTYYRNWI 412
             L G+ SWG  C  K   PGVY+ V+Y+  WI
Sbjct: 999  TLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWI 1030


>gi|5803197 testisin isoform 1 [Homo sapiens]
          Length = 314

 Score =  163 bits (413), Expect = 2e-40
 Identities = 93/253 (36%), Positives = 139/253 (54%), Gaps = 19/253 (7%)

Query: 175 CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKY-- 232
           CG+RV+    +RI  G  A    WPWQ SL+  + H CG +L+S+ W +TAAHCF+ Y  
Sbjct: 33  CGRRVI---TSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSD 89

Query: 233 -KNPHQWTVSFGTKINPP---LMKRNVRRFIIHEKYRS----AAREYDIAVVQVSSRVTF 284
             +P  W V FG   + P    ++    R+ +   Y S        YDIA+V++S+ VT+
Sbjct: 90  LSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTY 149

Query: 285 SDDIRQICLPEASASFQPNLTVHITGFGALYYGG--ESQNDLREARVKIISDDVCKQ--- 339
           +  I+ ICL  ++  F+      +TG+G +       S + L+E +V II++ +C     
Sbjct: 150 TKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFL 209

Query: 340 PQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKP 399
              +  DI   M CAG  +G  DAC GDSGGPL   +    WY IG+VSWG  CG+ ++P
Sbjct: 210 KYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLAC-NKNGLWYQIGVVSWGVGCGRPNRP 268

Query: 400 GVYTQVTYYRNWI 412
           GVYT ++++  WI
Sbjct: 269 GVYTNISHHFEWI 281


>gi|145275213 coagulation factor XII precursor [Homo sapiens]
          Length = 615

 Score =  162 bits (411), Expect = 4e-40
 Identities = 92/257 (35%), Positives = 140/257 (54%), Gaps = 15/257 (5%)

Query: 174 SCGKRVVPL--NVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQK 231
           SCG+R+     ++ R+  G++A + A P+ A+L + +   C  +LI+  W++TAAHC Q 
Sbjct: 358 SCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSF-CAGSLIAPCWVLTAAHCLQD 416

Query: 232 YKNPHQWTVSFGTKIN----PPLMKRNVRRFIIHEKYRSAAREYDIAVVQVS-----SRV 282
              P   TV  G +       P     VR + +HE +   + ++D+A++++      S  
Sbjct: 417 RPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCA 476

Query: 283 TFSDDIRQICLPEASASFQPNLTVHITGFGALYYGGESQND-LREARVKIISDDVCKQPQ 341
             S  ++ +CLP  +A         + G+G  + G E     L+EA+V  +S + C  P 
Sbjct: 477 LLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPD 536

Query: 342 VYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRD--LKDTWYLIGIVSWGDNCGQKDKP 399
           V+G+ I PGM CAG++EG  DAC+GDSGGPLV  D   +    L GI+SWG  CG ++KP
Sbjct: 537 VHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKP 596

Query: 400 GVYTQVTYYRNWIASKT 416
           GVYT V YY  WI   T
Sbjct: 597 GVYTDVAYYLAWIREHT 613


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  162 bits (410), Expect = 5e-40
 Identities = 84/238 (35%), Positives = 129/238 (54%), Gaps = 9/238 (3%)

Query: 186 RIASGVIAPKAAWPWQASLQYD---NIHQCGATLISNTWLVTAAHCFQKYKNPHQWTVSF 242
           RI  G  +    WPWQ SLQ       H CG +LI + W++TAAHCF        W +  
Sbjct: 390 RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYS 449

Query: 243 G----TKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEASA 298
           G    + I        ++  IIH+ Y+ +   +DIA++++ + + +++  + ICLP    
Sbjct: 450 GILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGD 509

Query: 299 SFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYME 358
           +        +TG+G     GE QN L++  + +++++ C Q +     I   M CAGY E
Sbjct: 510 TSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEEC-QKRYQDYKITQRMVCAGYKE 568

Query: 359 GIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKT 416
           G  DAC+GDSGGPLV +     W L+GI SWG+ C ++++PGVYT+V  Y +WI  KT
Sbjct: 569 GGKDACKGDSGGPLVCKH-NGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKT 625


>gi|21614531 testisin isoform 2 [Homo sapiens]
          Length = 312

 Score =  161 bits (407), Expect = 1e-39
 Identities = 92/251 (36%), Positives = 138/251 (54%), Gaps = 17/251 (6%)

Query: 175 CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQ-KYK 233
           CG+RV+    +RI  G  A    WPWQ SL+  + H CG +L+S+ W +TAAHCF+    
Sbjct: 33  CGRRVI---TSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLS 89

Query: 234 NPHQWTVSFGTKINPP---LMKRNVRRFIIHEKYRS----AAREYDIAVVQVSSRVTFSD 286
           +P  W V FG   + P    ++    R+ +   Y S        YDIA+V++S+ VT++ 
Sbjct: 90  DPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTK 149

Query: 287 DIRQICLPEASASFQPNLTVHITGFGALYYGG--ESQNDLREARVKIISDDVCKQ---PQ 341
            I+ ICL  ++  F+      +TG+G +       S + L+E +V II++ +C       
Sbjct: 150 HIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKY 209

Query: 342 VYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGV 401
            +  DI   M CAG  +G  DAC GDSGGPL   +    WY IG+VSWG  CG+ ++PGV
Sbjct: 210 SFRKDIFGDMVCAGNAQGGKDACFGDSGGPLAC-NKNGLWYQIGVVSWGVGCGRPNRPGV 268

Query: 402 YTQVTYYRNWI 412
           YT ++++  WI
Sbjct: 269 YTNISHHFEWI 279


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,885,788
Number of Sequences: 37866
Number of extensions: 606471
Number of successful extensions: 1900
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 158
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 1306
Number of HSP's gapped (non-prelim): 198
length of query: 418
length of database: 18,247,518
effective HSP length: 105
effective length of query: 313
effective length of database: 14,271,588
effective search space: 4467007044
effective search space used: 4467007044
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.