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Search of human proteins with 164519122
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|164519122 LGN protein [Homo sapiens]
(684 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|164519122 LGN protein [Homo sapiens] 1367 0.0
gi|224548927 G-protein signaling modulator 1 (AGS3-like, C. eleg... 714 0.0
gi|224548925 G-protein signaling modulator 1 (AGS3-like, C. eleg... 552 e-157
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 212 8e-55
gi|224548929 G-protein signaling modulator 1 (AGS3-like, C. eleg... 145 2e-34
gi|68299799 Purkinje cell protein 2 [Homo sapiens] 65 2e-10
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 57 4e-08
gi|15619013 43 kD receptor-associated protein of the synapse iso... 57 7e-08
gi|38045928 43 kD receptor-associated protein of the synapse iso... 57 7e-08
gi|13899233 tetratricopeptide repeat domain 25 [Homo sapiens] 54 4e-07
gi|157785672 tetratricopeptide repeat domain 24 [Homo sapiens] 51 3e-06
gi|148612821 tetratricopeptide repeat domain 29 [Homo sapiens] 50 7e-06
gi|145386551 SH3 domain and tetratricopeptide repeats 1 [Homo sa... 49 2e-05
gi|38488692 SH3 domain and tetratricopeptide repeats 2 [Homo sap... 48 3e-05
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 46 1e-04
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 46 1e-04
gi|11545817 G-protein signaling modulator 3 (AGS3-like, C. elega... 45 2e-04
gi|83415184 transmembrane and tetratricopeptide repeat containin... 45 2e-04
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 44 6e-04
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ... 44 6e-04
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 39 0.021
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 39 0.021
gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapi... 38 0.027
gi|22749211 transmembrane and tetratricopeptide repeat containin... 37 0.061
gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens] 37 0.061
gi|38569411 AP1 gamma subunit binding protein 1 isoform 2 [Homo ... 36 0.13
gi|38569409 AP1 gamma subunit binding protein 1 isoform 1 [Homo ... 36 0.13
gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens] 35 0.18
gi|21264343 scaffold attachment factor B [Homo sapiens] 35 0.23
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 35 0.30
>gi|164519122 LGN protein [Homo sapiens]
Length = 684
Score = 1367 bits (3538), Expect = 0.0
Identities = 684/684 (100%), Positives = 684/684 (100%)
Query: 1 MEENLISMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKT 60
MEENLISMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKT
Sbjct: 1 MEENLISMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKT 60
Query: 61 LSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDE 120
LSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDE
Sbjct: 61 LSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDE 120
Query: 121 AIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQA 180
AIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQA
Sbjct: 121 AIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQA 180
Query: 181 AVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAA 240
AVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAA
Sbjct: 181 AVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAA 240
Query: 241 ERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEK 300
ERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEK
Sbjct: 241 ERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEK 300
Query: 301 AIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSG 360
AIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSG
Sbjct: 301 AIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSG 360
Query: 361 ELTARLNLSDLQMVLGLSYSTNNSIMSENTEIDSSLNGVRPKLGRRHSMENMELMKLTPE 420
ELTARLNLSDLQMVLGLSYSTNNSIMSENTEIDSSLNGVRPKLGRRHSMENMELMKLTPE
Sbjct: 361 ELTARLNLSDLQMVLGLSYSTNNSIMSENTEIDSSLNGVRPKLGRRHSMENMELMKLTPE 420
Query: 421 KVQNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKTNSSTKVLQDASNSIDHRIPNSQR 480
KVQNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKTNSSTKVLQDASNSIDHRIPNSQR
Sbjct: 421 KVQNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKTNSSTKVLQDASNSIDHRIPNSQR 480
Query: 481 KISADTIGDEGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSSTPPKMMLKTSSVPVV 540
KISADTIGDEGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSSTPPKMMLKTSSVPVV
Sbjct: 481 KISADTIGDEGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSSTPPKMMLKTSSVPVV 540
Query: 541 SPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQSVLSHLMTNDNKEADEDFFDI 600
SPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQSVLSHLMTNDNKEADEDFFDI
Sbjct: 541 SPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQSVLSHLMTNDNKEADEDFFDI 600
Query: 601 LVKCQGSRLDDQRCAPPPATTKGPTVPDEDFFSLILRSQGKRMDEQRVLLQRDQNRDTDF 660
LVKCQGSRLDDQRCAPPPATTKGPTVPDEDFFSLILRSQGKRMDEQRVLLQRDQNRDTDF
Sbjct: 601 LVKCQGSRLDDQRCAPPPATTKGPTVPDEDFFSLILRSQGKRMDEQRVLLQRDQNRDTDF 660
Query: 661 GLKDFLQNNALLEFKNSGKKSADH 684
GLKDFLQNNALLEFKNSGKKSADH
Sbjct: 661 GLKDFLQNNALLEFKNSGKKSADH 684
>gi|224548927 G-protein signaling modulator 1 (AGS3-like, C.
elegans) isoform a [Homo sapiens]
Length = 675
Score = 714 bits (1844), Expect = 0.0
Identities = 379/639 (59%), Positives = 462/639 (72%), Gaps = 20/639 (3%)
Query: 19 RMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDY 78
RMEASCLELALEGERLCK+GD + GV+FFEAAVQVGTEDLKTLSAIYSQLGNAYFYL ++
Sbjct: 23 RMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEH 82
Query: 79 AKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDK 138
+ALEYH HDL LARTIGD++GEAKASGNLGNTLKVLG FDEA VCCQRHL I++E DK
Sbjct: 83 GRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDK 142
Query: 139 VGEARALYNLGNVYHAKGKSFG---CPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTAL 195
VGEARALYN+GNVYHAKGK QD G P +VR+ L A +FYE NLSLV L
Sbjct: 143 VGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKEL 202
Query: 196 GDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFL 255
GDRAAQGRA+GNLGNTHYLLGNF +A H++RL IAKEFGDKAAERRAYSNLGNA++FL
Sbjct: 203 GDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFL 262
Query: 256 GEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQEL 315
G F+ A+EYYKKTL L+RQL+D+AVEAQ+CYSLGNTYTLLQDYE+A +YHL+HL IAQEL
Sbjct: 263 GRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQEL 322
Query: 316 NDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVL 375
DR+GEGRACWSLGNAY ++G QA+ FA+KHL+IS+E+GD+ GELTAR+N++ LQ+VL
Sbjct: 323 ADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVL 382
Query: 376 GLSYSTNNSIMSENTEIDS-SLNGVRPKLGRRHSMENMELMKLTPEKVQNWNS----EIL 430
G + SE ++ G RPK +R S E +L++L E+ QN +S +
Sbjct: 383 G---RLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLEREQNGDSHHSGDWR 439
Query: 431 AKQKPLIAKPSAKLLFVNRLKGKKYKTNSSTKVLQDASNSIDHRIPNSQRKISADTIGDE 490
+ + P + ++ S L A + + R S+D +E
Sbjct: 440 GPSRDSLPLPVRSRKYQEGPDAERRPREGSHSPLDSADVRVHVPRTSIPRAPSSD---EE 496
Query: 491 GFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSSTPPKMMLKTSSVPVVSPNTDEFLDL 550
FFDLL++FQS+RMDDQRC L + A T + T + + S SP T+EF DL
Sbjct: 497 CFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSM--TASPQTEEFFDL 554
Query: 551 LASSQSRRLDDQRASFSNLPGLRLT-QNSQSVLSHLMTNDNKEADEDFFDILVKCQGSRL 609
+ASSQSRRLDDQRAS +LPGLR+T N+ + H + +E +DFF++L+K Q SR+
Sbjct: 555 IASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGH---GEPQEPGDDFFNMLIKYQSSRI 611
Query: 610 DDQRCAPPPATTKGPTVPDEDFFSLILRSQGKRMDEQRV 648
DDQRC PP +GPT+PDEDFFSLI R Q KRMDEQRV
Sbjct: 612 DDQRCPPPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRV 650
Score = 30.0 bits (66), Expect = 7.4
Identities = 14/39 (35%), Positives = 21/39 (53%)
Query: 616 PPPATTKGPTVPDEDFFSLILRSQGKRMDEQRVLLQRDQ 654
P + + P+ +E FF L+ + Q RMD+QR L Q
Sbjct: 483 PRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQ 521
>gi|224548925 G-protein signaling modulator 1 (AGS3-like, C.
elegans) isoform b [Homo sapiens]
Length = 457
Score = 552 bits (1422), Expect = e-157
Identities = 269/361 (74%), Positives = 311/361 (86%), Gaps = 3/361 (0%)
Query: 19 RMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDY 78
RMEASCLELALEGERLCK+GD + GV+FFEAAVQVGTEDLKTLSAIYSQLGNAYFYL ++
Sbjct: 23 RMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEH 82
Query: 79 AKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDK 138
+ALEYH HDL LARTIGD++GEAKASGNLGNTLKVLG FDEA VCCQRHL I++E DK
Sbjct: 83 GRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDK 142
Query: 139 VGEARALYNLGNVYHAKGKSFG---CPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTAL 195
VGEARALYN+GNVYHAKGK QD G P +VR+ L A +FYE NLSLV L
Sbjct: 143 VGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKEL 202
Query: 196 GDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFL 255
GDRAAQGRA+GNLGNTHYLLGNF +A H++RL IAKEFGDKAAERRAYSNLGNA++FL
Sbjct: 203 GDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFL 262
Query: 256 GEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQEL 315
G F+ A+EYYKKTL L+RQL+D+AVEAQ+CYSLGNTYTLLQDYE+A +YHL+HL IAQEL
Sbjct: 263 GRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQEL 322
Query: 316 NDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVL 375
DR+GEGRACWSLGNAY ++G QA+ FA+KHL+IS+E+GD+ GELTAR+N++ LQ+VL
Sbjct: 323 ADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVL 382
Query: 376 G 376
G
Sbjct: 383 G 383
Score = 103 bits (257), Expect = 5e-22
Identities = 68/240 (28%), Positives = 111/240 (46%), Gaps = 28/240 (11%)
Query: 32 ERLCKSGDCRAGVSFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDL 89
E LCK+ + F+E + + E D Y LGN ++ L ++ +A +H L
Sbjct: 183 ETLCKASE------FYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERL 236
Query: 90 TLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLG 149
+A+ GD+ E +A NLGN LG FD A ++ L +SR+L D+ EA+A Y+LG
Sbjct: 237 AIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLG 296
Query: 150 NVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLG 209
N Y + + A +++ +L + L DR +GRA +LG
Sbjct: 297 NTY--------------------TLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLG 336
Query: 210 NTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTL 269
N + +G A+ ++ L I++E GD+ E A N+ + LG + + K L
Sbjct: 337 NAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDL 396
Score = 77.4 bits (189), Expect = 4e-14
Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 12/153 (7%)
Query: 240 AERRAYSNL----------GNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLG 289
A RR YS + G G+F+T +++ + + + D + LG
Sbjct: 16 AARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLG 73
Query: 290 NTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHL 349
N Y L+++ +A++YH L +A+ + DR+GE +A +LGN LG D+A ++HL
Sbjct: 74 NAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHL 133
Query: 350 EISREVGDKSGELTARLNLSDLQMVLGLSYSTN 382
I++E GDK GE A N+ ++ G S N
Sbjct: 134 SIAQEQGDKVGEARALYNIGNVYHAKGKQLSWN 166
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 212 bits (540), Expect = 8e-55
Identities = 135/407 (33%), Positives = 215/407 (52%), Gaps = 27/407 (6%)
Query: 27 LALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHH 86
+++ G+ L +G A V EAA+++GT LK +++S L +AY+ L + K+ Y
Sbjct: 199 VSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQ 258
Query: 87 HDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALY 146
DL +A+T+GDQ GE +A GNLG+ GN+ EA+ + L ++ +L D+ + AL
Sbjct: 259 QDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALS 318
Query: 147 NLGNVYHAKG---------KSFGCPGPQDVGEFPEE-----------VRDALQAAVDFYE 186
+LG+VY A G K Q E E + AV +E
Sbjct: 319 SLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHE 378
Query: 187 ENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYS 246
++L + LG++ + RA+ NLG+ ++ NF A+ H L +A+E +KA E RAY+
Sbjct: 379 QHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYA 438
Query: 247 NLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHL 306
LG+A + + E A +Y+++ L +A LKDRA E ++ +LG + + DY+ A+ H
Sbjct: 439 GLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHK 498
Query: 307 KHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARL 366
HL IAQEL+D +GRA ++GNAY ALG +DQA+ + + L+IS EV D++ + +
Sbjct: 499 THLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHG 558
Query: 367 NLSDLQMVLGL------SYSTNNSIMSENTEIDSSLNGVRPKLGRRH 407
NL+ LG Y + +I E +I S + LG H
Sbjct: 559 NLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARAL-SNLGNFH 604
Score = 191 bits (485), Expect = 2e-48
Identities = 121/379 (31%), Positives = 200/379 (52%), Gaps = 38/379 (10%)
Query: 36 KSGDCRA----GVSFF--------------EAAVQVGTEDLKTLSAIYSQLGNAYFYLHD 77
++G+CRA G +FF + + + +D + S+ S LG+ Y + D
Sbjct: 270 QTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGD 329
Query: 78 YAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELND 137
Y AL H + LA+ D+L EA+ GN+G +G+F+ A+ C ++HL I+++L +
Sbjct: 330 YPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGN 389
Query: 138 KVGEARALYNLGNVYHAKGK--------SFGCPGPQDVGEFPEEVR------------DA 177
K EARA NLG+ YH + ++ Q++ E E+R
Sbjct: 390 KREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQD 449
Query: 178 LQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGD 237
L+ A ++E+ L + L DRAA+GRA NLG H + G++ A+ H+ L IA+E D
Sbjct: 450 LERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSD 509
Query: 238 KAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQD 297
AA+ RAY N+GNAY LG ++ A +Y+++ L ++ ++ DRA +A + +L Y L
Sbjct: 510 YAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGA 569
Query: 298 YEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGD 357
+++A+ ++ HL IA+EL D E RA +LGN + + G + QA + E++L ++ ++ D
Sbjct: 570 HDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQD 629
Query: 358 KSGELTARLNLSDLQMVLG 376
GE NL LG
Sbjct: 630 MEGEGKVCHNLGYAHYCLG 648
Score = 181 bits (460), Expect = 2e-45
Identities = 116/382 (30%), Positives = 192/382 (50%), Gaps = 30/382 (7%)
Query: 30 EGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAI---------YSQLGNAYFYLHDYAK 80
E L G + FE AVQ + LK + YS LG+AY Y ++ K
Sbjct: 353 EARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDK 412
Query: 81 ALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVG 140
A+ YH++ L LA+ + ++ E +A LG+ + + + + A ++ L I+ +L D+
Sbjct: 413 AMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAA 472
Query: 141 EARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAA 200
E RA NLG ++ KG A+ ++ +L + L D AA
Sbjct: 473 EGRASSNLGIIHQMKGD--------------------YDTALKLHKTHLCIAQELSDYAA 512
Query: 201 QGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFET 260
QGRA+GN+GN + LG + AV H Q L I+ E D+A++ + NL AY LG +
Sbjct: 513 QGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDR 572
Query: 261 ASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIG 320
A ++Y+ L +AR+L+D EA++ +LGN + +Y +A Y+ ++L +A +L D G
Sbjct: 573 ALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEG 632
Query: 321 EGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYS 380
EG+ C +LG A+ LGN+ +A+ + E+ L +++++ DK + A NL L L++S
Sbjct: 633 EGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLG-LAFKALLNFS 691
Query: 381 TNNSIMSENTEIDSSLNGVRPK 402
+ SLN + K
Sbjct: 692 KAEECQKYLLSLAQSLNNSQAK 713
Score = 179 bits (453), Expect = 1e-44
Identities = 108/312 (34%), Positives = 169/312 (54%), Gaps = 20/312 (6%)
Query: 65 YSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVC 124
Y +GNAY L Y +A++YH +L ++ + D+ +A GNL + LG D A+
Sbjct: 517 YGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQH 576
Query: 125 CQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDF 184
Q HL+I+REL D EARAL NLGN + ++G + +QAA +
Sbjct: 577 YQNHLNIARELRDIQSEARALSNLGNFHCSRG-------------------EYVQAA-PY 616
Query: 185 YEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRA 244
YE+ L L L D +G+ NLG HY LGN+++AV +EQ L +AK+ DK ++ +A
Sbjct: 617 YEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKA 676
Query: 245 YSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDY 304
Y NLG A+ L F A E K L LA+ L + + ++ +LG+ + +D AI +
Sbjct: 677 YCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKF 736
Query: 305 HLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTA 364
+ + L +A ++ DR E A +LG AY + +D+A+ + + LE+ +E+ D GE A
Sbjct: 737 YEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRA 796
Query: 365 RLNLSDLQMVLG 376
+L+ + M LG
Sbjct: 797 HGHLAAVYMALG 808
Score = 174 bits (440), Expect = 3e-43
Identities = 113/407 (27%), Positives = 200/407 (49%), Gaps = 39/407 (9%)
Query: 34 LCKSGDCRAGVSFFEAAVQVG--TEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTL 91
+CK D + F+E + + +D + ++ Y+ LG AY + Y KAL YH +L +
Sbjct: 725 ICKK-DINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEV 783
Query: 92 ARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLG-- 149
+ + D GE +A G+L LG + A C + LD+ ++L D EA+ N+G
Sbjct: 784 YQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGIT 843
Query: 150 ----NVYHA-----------------------KGKSFGCPGPQDVGEFPEEVRDALQAAV 182
NV +G+++G ++G+ E + D + A+
Sbjct: 844 KMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYG-----NLGDCYEALGD-YEEAI 897
Query: 183 DFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAER 242
+YE+ LS+ +L Q +A+ LGN H +G+ + A++ E+RL++A E G+ +
Sbjct: 898 KYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKA 957
Query: 243 RAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAI 302
+AY LG+ + LG +E A ++ L +AR +KDRA+E+ + LG Y + +Y+ A+
Sbjct: 958 QAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTAL 1017
Query: 303 DYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGEL 362
YH L IA+E N+ +GRA +LG Y +LG ++A+ + E+HL I+ ++ D + +
Sbjct: 1018 QYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKT 1077
Query: 363 TARLNLSDLQMVLGLSYSTNNSIMSENTEIDSSLNGVRPKLGRRHSM 409
+ +L L +YS + E + L + RH +
Sbjct: 1078 VSYSSLGRTHHAL-QNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGL 1123
Score = 156 bits (395), Expect = 5e-38
Identities = 98/347 (28%), Positives = 180/347 (51%), Gaps = 25/347 (7%)
Query: 35 CKSGDCRAGVSFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLA 92
C G+ ++E +++ + D++ + LG A++ L +Y +A++Y+ DL LA
Sbjct: 605 CSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALA 664
Query: 93 RTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVY 152
+ + D+L +AKA NLG K L NF +A C + L +++ LN+ + RAL NLG+++
Sbjct: 665 KDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIF 724
Query: 153 HAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTH 212
K + A+ FYE+ L L + DR + A+ LG +
Sbjct: 725 ICKKD--------------------INGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAY 764
Query: 213 YLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLA 272
++ + A+ H Q L + +E D E RA+ +L Y+ LG++ A + Y++ L L
Sbjct: 765 RMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLG 824
Query: 273 RQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDR---IGEGRACWSLG 329
++LKD ++EAQ ++G T + E+AI Y + LA+ Q+L+ + GRA +LG
Sbjct: 825 QKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLG 884
Query: 330 NAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLG 376
+ Y ALG++++A+ + E++L +++ + + A L + +G
Sbjct: 885 DCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMG 931
Score = 140 bits (353), Expect = 4e-33
Identities = 87/290 (30%), Positives = 145/290 (50%), Gaps = 20/290 (6%)
Query: 54 GTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLK 113
G E + Y LG+ Y L DY +A++Y+ L++A+++ +AKA LGN +
Sbjct: 869 GNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHR 928
Query: 114 VLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEE 173
+G+ +A+VC ++ L ++ EL + +A+A LG+++ G
Sbjct: 929 AMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGN---------------- 972
Query: 174 VRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAK 233
+ A+ E L++ + DRA + A LG + +G + A+ H+ L IA+
Sbjct: 973 ----YEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAE 1028
Query: 234 EFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYT 293
E + + RAY NLG Y LG FE A Y ++ L +A Q+ D A + S SLG T+
Sbjct: 1029 ETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHH 1088
Query: 294 LLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMH 343
LQ+Y +A+ Y + L +A++L R E + LG + A GN ++A H
Sbjct: 1089 ALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQH 1138
Score = 115 bits (289), Expect = 1e-25
Identities = 109/446 (24%), Positives = 192/446 (43%), Gaps = 26/446 (5%)
Query: 21 EASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAK 80
+A +E + + C GD + + A+ V ++ +YS AY + Y K
Sbjct: 55 KAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNC----ILYSNRSAAYMKIQQYDK 110
Query: 81 ALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHL-DISRELNDKV 139
AL+ D AR + + KA G L+ LG +A+ L + L V
Sbjct: 111 ALD----DAIKARLLNPKW--PKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLV 164
Query: 140 GEARALY------NLGNVYHAKGKSFGCPGP-QDVGEFPEEVRDALQAAVDFYEENLSLV 192
G A +L Y K P V +E+ A +L
Sbjct: 165 GMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALK 224
Query: 193 TALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAY 252
+G F L + ++ LGN + +Q L +AK GD+ E RA+ NLG+A+
Sbjct: 225 IGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAF 284
Query: 253 IFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIA 312
G + A ++ L+LA +LKDR + + SLG+ YT + DY A+ H + + +A
Sbjct: 285 FSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLA 344
Query: 313 QELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSD-- 370
++ D + E R ++G Y A+G+ + A+ E+HL+I++++G+K E A NL
Sbjct: 345 KQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAY 404
Query: 371 -LQMVLGLSYSTNNSIMSENTEIDSSLNGVRPKLGRRHS---MENMELMKLTPEKVQNWN 426
+ + S +N ++ E+ +R G H+ M+++E K E+
Sbjct: 405 HYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIA 464
Query: 427 SEILAKQKPLIAKPSAKLLFVNRLKG 452
++ K + + S+ L ++++KG
Sbjct: 465 EDL--KDRAAEGRASSNLGIIHQMKG 488
>gi|224548929 G-protein signaling modulator 1 (AGS3-like, C.
elegans) isoform c [Homo sapiens]
Length = 166
Score = 145 bits (365), Expect = 2e-34
Identities = 78/146 (53%), Positives = 98/146 (67%), Gaps = 6/146 (4%)
Query: 504 MDDQRCCLQEKNCHTASTTTSSTPPKMMLKTSSVPVVSPNTDEFLDLLASSQSRRLDDQR 563
MDDQRC L + A T + T + + S SP T+EF DL+ASSQSRRLDDQR
Sbjct: 1 MDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMT--ASPQTEEFFDLIASSQSRRLDDQR 58
Query: 564 ASFSNLPGLRLTQNSQSVLSHLMTN-DNKEADEDFFDILVKCQGSRLDDQRCAPPPATTK 622
AS +LPGLR+T ++ HL + + +E +DFF++L+K Q SR+DDQRC PP +
Sbjct: 59 ASVGSLPGLRITHSNAG---HLRGHGEPQEPGDDFFNMLIKYQSSRIDDQRCPPPDVLPR 115
Query: 623 GPTVPDEDFFSLILRSQGKRMDEQRV 648
GPT+PDEDFFSLI R Q KRMDEQRV
Sbjct: 116 GPTMPDEDFFSLIQRVQAKRMDEQRV 141
Score = 47.4 bits (111), Expect = 4e-05
Identities = 43/166 (25%), Positives = 68/166 (40%), Gaps = 29/166 (17%)
Query: 467 ASNSIDHRIPNSQRKISADTIGDEGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSST 526
A+ +++ RI S T E FFDL++ QS R+DDQR + + + +
Sbjct: 20 AAPTLEDRIAQPSMTASPQT---EEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAG- 75
Query: 527 PPKMMLKTSSVPVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQSVLSHLM 586
L+ P D+F ++L QS R+DDQR + ++
Sbjct: 76 ----HLRGHGEP--QEPGDDFFNMLIKYQSSRIDDQRCPPPD----------------VL 113
Query: 587 TNDNKEADEDFFDILVKCQGSRLDDQR---CAPPPATTKGPTVPDE 629
DEDFF ++ + Q R+D+QR P GP P +
Sbjct: 114 PRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGGPEQGAGGPPEPQQ 159
>gi|68299799 Purkinje cell protein 2 [Homo sapiens]
Length = 136
Score = 65.1 bits (157), Expect = 2e-10
Identities = 36/84 (42%), Positives = 48/84 (57%), Gaps = 15/84 (17%)
Query: 490 EGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSSTPPKMMLKTSSVPVVSPNTDEFLD 549
EGFF+LLS Q +RM+ QRC LQ TT S + P +P D +D
Sbjct: 24 EGFFNLLSHVQGDRMEGQRCSLQ---AGPGQTTKSQSDP------------TPEMDSLMD 68
Query: 550 LLASSQSRRLDDQRASFSNLPGLR 573
+LAS+Q RR+DDQR + S+LPG +
Sbjct: 69 MLASTQGRRMDDQRVTVSSLPGFQ 92
Score = 45.4 bits (106), Expect = 2e-04
Identities = 25/60 (41%), Positives = 35/60 (58%), Gaps = 6/60 (10%)
Query: 595 EDFFDILVKCQGSRLDDQRC---APPPATTKG---PTVPDEDFFSLILRSQGKRMDEQRV 648
E FF++L QG R++ QRC A P TTK PT + ++ +QG+RMD+QRV
Sbjct: 24 EGFFNLLSHVQGDRMEGQRCSLQAGPGQTTKSQSDPTPEMDSLMDMLASTQGRRMDDQRV 83
Score = 38.5 bits (88), Expect = 0.021
Identities = 26/73 (35%), Positives = 35/73 (47%), Gaps = 10/73 (13%)
Query: 541 SPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQSVLSHLMTNDNKEADEDFFDI 600
SP+ + F +LL+ Q R++ QR S PG T SQS D + D+
Sbjct: 20 SPDQEGFFNLLSHVQGDRMEGQRCSLQAGPG--QTTKSQS--------DPTPEMDSLMDM 69
Query: 601 LVKCQGSRLDDQR 613
L QG R+DDQR
Sbjct: 70 LASTQGRRMDDQR 82
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 57.4 bits (137), Expect = 4e-08
Identities = 83/352 (23%), Positives = 138/352 (39%), Gaps = 65/352 (18%)
Query: 62 SAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEA 121
+A+ QLG YA+ALE H +L L D LG A A +G L + ++ A
Sbjct: 27 AALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGERLAEMEDYPAA 86
Query: 122 IVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAA 181
+ ++L+++ L + RA +G + D+ + + RDAL A
Sbjct: 87 LQHQHQYLELAHSLRNHTELQRAWATIGRTH------------LDIYDHCQS-RDALLQA 133
Query: 182 VDFYEENLSLV-TALGDRAAQG-------RAFGNLGNTHYLLGN-------FRDAVIAHE 226
+E++L++V L AQG R + NLG T L FR ++ E
Sbjct: 134 QAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIFLAE 193
Query: 227 QRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCY 286
Q L F RA NLG + G+ A + A ++ R +E++ C
Sbjct: 194 QNHLYEDLF-------RARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFMESECCV 246
Query: 287 SLGNTYTLLQDY--------------------EKAIDYHLKHLAIAQELNDRI--GEGR- 323
+ L D+ AI +L+H+ L ++ EGR
Sbjct: 247 VIAQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLEEAEGRD 306
Query: 324 ------ACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLS 369
C LG+ ++ G+ +A +K L + E+ D+ G A +++S
Sbjct: 307 PQGAMVICEQLGDLFSKAGDFPRAAEAYQKQLRFA-ELLDRPGAERAIIHVS 357
Score = 39.3 bits (90), Expect = 0.012
Identities = 76/372 (20%), Positives = 129/372 (34%), Gaps = 77/372 (20%)
Query: 48 EAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGN 107
E ++ +D + + ++G + DY AL++ H L LA ++ + +A
Sbjct: 53 ELQLRERADDPLGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWAT 112
Query: 108 LGNT--------------LKVLGNFDEAIVCCQRHLD---ISRELNDKVGEARALYNLGN 150
+G T L+ F++++ L+ ELN+ R NLG
Sbjct: 113 IGRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEM--RTRLYLNLGL 170
Query: 151 VYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGN 210
+ + ++ C D++ +++ L RA NLG
Sbjct: 171 TFESLQQTALCN--------------------DYFRKSIFLAEQNHLYEDLFRARYNLGT 210
Query: 211 THYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLL 270
H+ G A+ E A + E + LG+F A KK
Sbjct: 211 IHWRAGQHSQAMRCLEGARECAHTMRKRFMESECCVVIAQVLQDLGDFLAAKRALKKAYR 270
Query: 271 LARQ--------------------LKDRAVEAQS---------CYSLGNTYTLLQDYEKA 301
L Q L+ + EA+ C LG+ ++ D+ +A
Sbjct: 271 LGSQKPVQRAAICQNLQHVLAVVRLQQQLEEAEGRDPQGAMVICEQLGDLFSKAGDFPRA 330
Query: 302 IDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALG----NHDQAMHFAEKHLEISREVGD 357
+ + K L A EL DR G RA + A T LG +H H+ E E+ G+
Sbjct: 331 AEAYQKQLRFA-ELLDRPGAERAIIHVSLA-TTLGDMKDHHGAVRHYEE---ELRLRSGN 385
Query: 358 KSGELTARLNLS 369
E LN++
Sbjct: 386 VLEEAKTWLNIA 397
>gi|15619013 43 kD receptor-associated protein of the synapse
isoform 1 [Homo sapiens]
Length = 412
Score = 56.6 bits (135), Expect = 7e-08
Identities = 44/194 (22%), Positives = 82/194 (42%), Gaps = 9/194 (4%)
Query: 172 EEVRDALQAAVDFYEENLS---------LVTALGDRAAQGRAFGNLGNTHYLLGNFRDAV 222
++ + ++ + Y+ N + ++ D + R G L H +G +++ +
Sbjct: 4 DQTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEML 63
Query: 223 IAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEA 282
++ A+E D +Y NL + L EF Y K L L +
Sbjct: 64 KFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGG 123
Query: 283 QSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAM 342
Q S+GN + L ++KA++ K L A +D + E R C SLG+ Y + ++++A+
Sbjct: 124 QVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKAL 183
Query: 343 HFAEKHLEISREVG 356
F K E+ G
Sbjct: 184 FFPCKAAELVNNYG 197
Score = 52.8 bits (125), Expect = 1e-06
Identities = 59/290 (20%), Positives = 119/290 (41%), Gaps = 25/290 (8%)
Query: 97 DQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGN------ 150
D +G + G L +G + E + +D +REL D + NL
Sbjct: 38 DLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLC 97
Query: 151 -----VYHAKGKSFGCPGPQDVGEFPEEVR----------DALQAAVDFYEENLSLVTAL 195
+ + K G PG + + +V Q A++ +E+ L
Sbjct: 98 EFHKTISYCK-TCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNN 156
Query: 196 GDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDK-AAERRAYS--NLGNAY 252
D + R +LG+ + + ++ A+ + + +G + + RA S ++ AY
Sbjct: 157 DDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAY 216
Query: 253 IFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIA 312
LG +A E ++++ +A Q DR ++A + + D E A + ++I
Sbjct: 217 RLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIM 276
Query: 313 QELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGEL 362
E+ +R+G+ +A + + A D+A+ E+ +++ EVG+K +L
Sbjct: 277 TEIGNRLGQVQALLGVAKCWVARKALDKALDAIERAQDLAEEVGNKLSQL 326
Score = 52.0 bits (123), Expect = 2e-06
Identities = 71/356 (19%), Positives = 134/356 (37%), Gaps = 40/356 (11%)
Query: 49 AAVQVGT----EDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLART-IGDQLGEAK 103
A VQ+ T ED L Y L + L ++ K + Y L L T G QLG +
Sbjct: 66 AVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLG-GQ 124
Query: 104 ASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVY-----HAKGKS 158
S ++GN L F +A+ ++ L + +D + E R +LG+ Y + K
Sbjct: 125 VSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALF 184
Query: 159 FGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNF 218
F C + V + + +A ++ + + LLG
Sbjct: 185 FPCKAAELVNNYGKGWSLKYRAMSQYH----------------------MAVAYRLLGRL 222
Query: 219 RDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDR 278
A+ E+ + IA + GD+ + + + G+ ETA Y + + ++ +R
Sbjct: 223 GSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNR 282
Query: 279 AVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNH 338
+ Q+ + + + +KA+D + +A+E+ +++ + + + Y + G
Sbjct: 283 LGQVQALLGVAKCWVARKALDKALDAIERAQDLAEEVGNKLSQLKLHCLSESIYRSKGLQ 342
Query: 339 DQAMHFAEKHLEISREV-------GDKSGELTARLNLSDLQMVLGLSYSTNNSIMS 387
+ + E E G+ GE +RL + L NN S
Sbjct: 343 RELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCLQNNGTRS 398
Score = 31.2 bits (69), Expect = 3.3
Identities = 19/71 (26%), Positives = 37/71 (52%), Gaps = 3/71 (4%)
Query: 299 EKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDK 358
EKA+ K + ++ +D +G R L A++ +G + + + FA ++ +RE+ D
Sbjct: 23 EKALQVWTK---VLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDA 79
Query: 359 SGELTARLNLS 369
L + LNL+
Sbjct: 80 DFLLESYLNLA 90
>gi|38045928 43 kD receptor-associated protein of the synapse
isoform 2 [Homo sapiens]
Length = 353
Score = 56.6 bits (135), Expect = 7e-08
Identities = 44/194 (22%), Positives = 82/194 (42%), Gaps = 9/194 (4%)
Query: 172 EEVRDALQAAVDFYEENLS---------LVTALGDRAAQGRAFGNLGNTHYLLGNFRDAV 222
++ + ++ + Y+ N + ++ D + R G L H +G +++ +
Sbjct: 4 DQTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEML 63
Query: 223 IAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEA 282
++ A+E D +Y NL + L EF Y K L L +
Sbjct: 64 KFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGG 123
Query: 283 QSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAM 342
Q S+GN + L ++KA++ K L A +D + E R C SLG+ Y + ++++A+
Sbjct: 124 QVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKAL 183
Query: 343 HFAEKHLEISREVG 356
F K E+ G
Sbjct: 184 FFPCKAAELVNNYG 197
Score = 37.0 bits (84), Expect = 0.061
Identities = 29/140 (20%), Positives = 57/140 (40%), Gaps = 12/140 (8%)
Query: 29 LEGERLCKSGDCRAGVSFFEAAVQV---------GTEDLKTLSAIYSQLGNAYFYLHDYA 79
L G+ G+ G+S F+ A++ +D + LG+ Y + DY
Sbjct: 121 LGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYE 180
Query: 80 KALEYHHHDLTLARTIGDQLG---EAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELN 136
KAL + L G A + ++ ++LG A+ CC+ + I+ +
Sbjct: 181 KALFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHG 240
Query: 137 DKVGEARALYNLGNVYHAKG 156
D+ +A L +++ ++G
Sbjct: 241 DRPLQALCLLCFADIHRSRG 260
Score = 35.8 bits (81), Expect = 0.13
Identities = 55/254 (21%), Positives = 95/254 (37%), Gaps = 40/254 (15%)
Query: 49 AAVQVGT----EDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLART-IGDQLGEAK 103
A VQ+ T ED L Y L + L ++ K + Y L L T G QLG +
Sbjct: 66 AVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLG-GQ 124
Query: 104 ASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVY-----HAKGKS 158
S ++GN L F +A+ ++ L + +D + E R +LG+ Y + K
Sbjct: 125 VSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALF 184
Query: 159 FGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNF 218
F C + V + + +A ++ + + LLG
Sbjct: 185 FPCKAAELVNNYGKGWSLKYRAMSQYH----------------------MAVAYRLLGRL 222
Query: 219 RDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETA-------SEYYKKTLLL 271
A+ E+ + IA + GD+ + + + G+ E + SE ++ L
Sbjct: 223 GSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLELSQLKLHCLSESIYRSKGL 282
Query: 272 ARQLKDRAVEAQSC 285
R+L+ V C
Sbjct: 283 QRELRAHVVRFHEC 296
Score = 31.6 bits (70), Expect = 2.5
Identities = 27/127 (21%), Positives = 51/127 (40%)
Query: 231 IAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGN 290
+ ++ D R L A+ +G ++ ++ + AR+L+D +S +L
Sbjct: 32 VLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLAR 91
Query: 291 TYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLE 350
+ L ++ K I Y L + G+ S+GNA+ L +A+ EK L
Sbjct: 92 SNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALR 151
Query: 351 ISREVGD 357
+ D
Sbjct: 152 YAHNNDD 158
Score = 31.2 bits (69), Expect = 3.3
Identities = 19/71 (26%), Positives = 37/71 (52%), Gaps = 3/71 (4%)
Query: 299 EKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDK 358
EKA+ K + ++ +D +G R L A++ +G + + + FA ++ +RE+ D
Sbjct: 23 EKALQVWTK---VLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDA 79
Query: 359 SGELTARLNLS 369
L + LNL+
Sbjct: 80 DFLLESYLNLA 90
>gi|13899233 tetratricopeptide repeat domain 25 [Homo sapiens]
Length = 672
Score = 54.3 bits (129), Expect = 4e-07
Identities = 54/228 (23%), Positives = 103/228 (45%), Gaps = 10/228 (4%)
Query: 202 GRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETA 261
G + +GN LG A+ +H + L IAKE+ A+ RA N+G + +G+F+ A
Sbjct: 320 GNLYSCIGNAQIELGQMEAALQSHRKDLEIAKEYDLPDAKSRALDNIGRVFARVGKFQQA 379
Query: 262 SEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGE 321
+ +++ + LA+ ++ + +G Y L +A +Y K A+E D +
Sbjct: 380 IDTWEEKIPLAKTTLEK---TWLFHEIGRCYLELDQAWQAQNYGEKSQQCAEEEGDIEWQ 436
Query: 322 GRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYST 381
A + A L + + A++ EK LE ++ V + + L D +
Sbjct: 437 LNASVLVAQAQVKLRDFESAVNNFEKALERAKLVHNNEAQQAIISALDDANKGIIRELRK 496
Query: 382 NNSI--MSENTEIDSSLNGVRPKLGRRHSMENMELMKLTPEK-VQNWN 426
N + + E +E ++SL ++ R ++M ++ PEK V+ W+
Sbjct: 497 TNYVENLKEKSEGEASL--YEDRIITRE--KDMRRVRDEPEKVVKQWD 540
Score = 38.1 bits (87), Expect = 0.027
Identities = 43/188 (22%), Positives = 76/188 (40%), Gaps = 23/188 (12%)
Query: 64 IYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIV 123
+YS +GNA L AL+ H DL +A+ +++A N+G +G F +AI
Sbjct: 322 LYSCIGNAQIELGQMEAALQSHRKDLEIAKEYDLPDAKSRALDNIGRVFARVGKFQQAID 381
Query: 124 CCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVD 183
+ + +++ +K ++H ++G E+ A QA +
Sbjct: 382 TWEEKIPLAKTTLEKTW----------LFH------------EIGRCYLELDQAWQAQ-N 418
Query: 184 FYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERR 243
+ E++ GD Q A + L +F AV E+ L AK + A++
Sbjct: 419 YGEKSQQCAEEEGDIEWQLNASVLVAQAQVKLRDFESAVNNFEKALERAKLVHNNEAQQA 478
Query: 244 AYSNLGNA 251
S L +A
Sbjct: 479 IISALDDA 486
>gi|157785672 tetratricopeptide repeat domain 24 [Homo sapiens]
Length = 302
Score = 51.2 bits (121), Expect = 3e-06
Identities = 35/117 (29%), Positives = 59/117 (50%), Gaps = 1/117 (0%)
Query: 251 AYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLA 310
A+ LG ++ A E+++K L + R + +S SL + L D++ A D +L L
Sbjct: 2 AHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQ 61
Query: 311 IAQELNDRIGEGRACWSLGNAYTALGNHDQAM-HFAEKHLEISREVGDKSGELTARL 366
A++ D G+ +AC LG A LG +DQA+ ++ E + +E L A+L
Sbjct: 62 AARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRERLVAKL 118
Score = 51.2 bits (121), Expect = 3e-06
Identities = 32/103 (31%), Positives = 54/103 (52%)
Query: 179 QAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDK 238
Q A +F+++ L ++G R QGR+FG+L LG+ + A + L A++ GD
Sbjct: 10 QEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARDSGDM 69
Query: 239 AAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVE 281
+ +A LG A LG+++ A +YYK+ L ++ D E
Sbjct: 70 KGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRE 112
Score = 50.8 bits (120), Expect = 4e-06
Identities = 31/110 (28%), Positives = 54/110 (49%)
Query: 212 HYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLL 271
H LGN+++A H++ + G + + R++ +L A LG+ + A + Y L
Sbjct: 3 HNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQA 62
Query: 272 ARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGE 321
AR D + Q+C LG L Y++A+ Y+ + LA Q+ D + E
Sbjct: 63 ARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRE 112
Score = 35.8 bits (81), Expect = 0.13
Identities = 25/77 (32%), Positives = 34/77 (44%), Gaps = 7/77 (9%)
Query: 65 YSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFD----- 119
+ L A L D+ A + + H L AR GD G+ +A LG LG +D
Sbjct: 36 FGSLAFALSQLGDHKAARDNYLHALQAARDSGDMKGQWQACEGLGAAAARLGQYDQALKY 95
Query: 120 --EAIVCCQRHLDISRE 134
EA+ CQ+ D RE
Sbjct: 96 YKEALAQCQKEPDSVRE 112
Score = 31.6 bits (70), Expect = 2.5
Identities = 21/79 (26%), Positives = 37/79 (46%)
Query: 71 AYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLD 130
A+ L +Y +A E+H L ++G + + ++ G+L L LG+ A L
Sbjct: 2 AHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQ 61
Query: 131 ISRELNDKVGEARALYNLG 149
+R+ D G+ +A LG
Sbjct: 62 AARDSGDMKGQWQACEGLG 80
>gi|148612821 tetratricopeptide repeat domain 29 [Homo sapiens]
Length = 475
Score = 50.1 bits (118), Expect = 7e-06
Identities = 49/167 (29%), Positives = 81/167 (48%), Gaps = 19/167 (11%)
Query: 230 LIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKK--TLLLARQLKD---RAVEAQS 284
LI + G K AE A+ ++G Y G+ A+E+Y+ L R KD R++ +
Sbjct: 172 LIKIDCGKKEAE--AHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRIWKDETGRSLNLLA 229
Query: 285 CYSLGNTYTLLQD-------YEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGN 337
C SL TY LL D Y++AI +K IA+E +D+ E A + LG A+ A
Sbjct: 230 CESLLRTYRLLSDKMLENKEYKQAIKILIKASEIAKEGSDKKMEAEASYYLGLAHLAAEE 289
Query: 338 HDQAMHFAEKHLEISREVGD-----KSGELTARLNLSDLQMVLGLSY 379
++ A+ + + +IS ++ D + E A++ S +M + Y
Sbjct: 290 YETALTVLDTYCKISTDLDDDLSLGRGYEAIAKVLQSQGEMTEAIKY 336
Score = 45.4 bits (106), Expect = 2e-04
Identities = 26/111 (23%), Positives = 57/111 (51%)
Query: 243 RAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAI 302
R Y L + + E++ A + K +A++ D+ +EA++ Y LG + ++YE A+
Sbjct: 235 RTYRLLSDKMLENKEYKQAIKILIKASEIAKEGSDKKMEAEASYYLGLAHLAAEEYETAL 294
Query: 303 DYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISR 353
+ I+ +L+D + GR ++ + G +A+ + +K ++I+R
Sbjct: 295 TVLDTYCKISTDLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIAR 345
Score = 40.4 bits (93), Expect = 0.005
Identities = 45/191 (23%), Positives = 82/191 (42%), Gaps = 9/191 (4%)
Query: 231 IAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGN 290
IAKE DK E A LG A++ E+ETA ++ L D + ++
Sbjct: 263 IAKEGSDKKMEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLGRGYEAIAK 322
Query: 291 TYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLE 350
+ +AI Y K + IA+ + RA LG+ Y G +++A E
Sbjct: 323 VLQSQGEMTEAIKYLKKFVKIARNNFQSLDLVRASTMLGDIYNEKGYYNKAS-------E 375
Query: 351 ISREVGDKSGELTARLNLSDLQMVLGLSYSTNNSIMSENTEIDSS-LNGVRPKLGRRHSM 409
++ D + EL + + + ++ G++ + +++ N I+S+ L + L + S
Sbjct: 376 CFQQAFDTTVELMSMPLMDETKVHYGIA-KAHQMMLTVNNYIESADLTSLNYLLSWKESR 434
Query: 410 ENMELMKLTPE 420
N+E +T E
Sbjct: 435 GNIEPDPVTEE 445
Score = 33.5 bits (75), Expect = 0.67
Identities = 47/191 (24%), Positives = 78/191 (40%), Gaps = 30/191 (15%)
Query: 87 HDLTLARTIGDQLGEAK---ASGNLGNTLKVLGN-------FDEAIVCCQRHLDISRELN 136
H LT R D+ G + A +L T ++L + + +AI + +I++E +
Sbjct: 209 HQLTQGRIWKDETGRSLNLLACESLLRTYRLLSDKMLENKEYKQAIKILIKASEIAKEGS 268
Query: 137 DKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALG 196
DK EA A Y LG + A EE AL +D Y + T L
Sbjct: 269 DKKMEAEASYYLGLAHLAA----------------EEYETAL-TVLDTY---CKISTDLD 308
Query: 197 DRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLG 256
D + GR + + G +A+ ++ + IA+ RA + LG+ Y G
Sbjct: 309 DDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDLVRASTMLGDIYNEKG 368
Query: 257 EFETASEYYKK 267
+ ASE +++
Sbjct: 369 YYNKASECFQQ 379
Score = 33.1 bits (74), Expect = 0.87
Identities = 27/130 (20%), Positives = 54/130 (41%), Gaps = 2/130 (1%)
Query: 29 LEGERLCKSGDCRAGVSFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLHDYAKALEYHH 86
L +++ ++ + + + A ++ E D K + LG A+ +Y AL
Sbjct: 239 LLSDKMLENKEYKQAIKILIKASEIAKEGSDKKMEAEASYYLGLAHLAAEEYETALTVLD 298
Query: 87 HDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALY 146
++ + D L + + L+ G EAI ++ + I+R + RA
Sbjct: 299 TYCKISTDLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDLVRAST 358
Query: 147 NLGNVYHAKG 156
LG++Y+ KG
Sbjct: 359 MLGDIYNEKG 368
Score = 30.0 bits (66), Expect = 7.4
Identities = 24/105 (22%), Positives = 39/105 (37%)
Query: 197 DRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLG 256
D+ + A LG H + A+ + I+ + D + R Y + G
Sbjct: 269 DKKMEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLGRGYEAIAKVLQSQG 328
Query: 257 EFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKA 301
E A +Y KK + +AR ++ LG+ Y Y KA
Sbjct: 329 EMTEAIKYLKKFVKIARNNFQSLDLVRASTMLGDIYNEKGYYNKA 373
>gi|145386551 SH3 domain and tetratricopeptide repeats 1 [Homo
sapiens]
Length = 1336
Score = 48.9 bits (115), Expect = 2e-05
Identities = 74/343 (21%), Positives = 127/343 (37%), Gaps = 63/343 (18%)
Query: 80 KALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKV 139
+A E ++ L +AR +G Q +A N G G A Q +L + L ++
Sbjct: 881 QAAESYYRALRVARDLGQQRNQAVGLANFGALCLHAG----ASRLAQHYLLEAVRLFSRL 936
Query: 140 GEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRA 199
+ +V G GP G+ +YE L + +G
Sbjct: 937 PLGECGRDFTHVLLQLGHLCTRQGPAQQGK-------------GYYEWALLVAVEMGHVE 983
Query: 200 AQGRAFGNLGNTHY-LLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGE- 257
+Q RA L + + ++ + VI HE +L +A + DK E + + Y+ LG
Sbjct: 984 SQLRAVQRLCHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTE 1043
Query: 258 --FETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQ------------------- 296
+++A +Y K++L + L+ + EA + G Y +L+
Sbjct: 1044 RAYKSALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYT 1103
Query: 297 ----------------------DYEKAIDYHL-KHLAIAQELNDRIGEGRACWSLGNAYT 333
+ EKA+ ++ + L +A +R E R C L
Sbjct: 1104 GDPNLGLELFEAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLA 1163
Query: 334 ALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLG 376
L + + FA L +S +GD+ E A L+ LQ LG
Sbjct: 1164 TLEEPQEGLEFAHMALALSITLGDRLNERVAYHRLAALQHRLG 1206
Score = 45.8 bits (107), Expect = 1e-04
Identities = 49/235 (20%), Positives = 96/235 (40%), Gaps = 21/235 (8%)
Query: 120 EAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQ 179
+ ++ + L ++ ++ DKV E + L + +Y + G A +
Sbjct: 1005 QCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLG-----------------TERAYK 1047
Query: 180 AAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKA 239
+A+D+ + +L + L + + A+ G +Y+L + + +A GD
Sbjct: 1048 SALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPN 1107
Query: 240 AERRAYSNLGNAYIFLGEFE---TASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQ 296
+ G+ + F G +E S Y + L LA +R E + C L L+
Sbjct: 1108 LGLELFEAAGDIF-FDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLE 1166
Query: 297 DYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEI 351
+ ++ +++ LA++ L DR+ E A L LG+ + A HF K L +
Sbjct: 1167 EPQEGLEFAHMALALSITLGDRLNERVAYHRLAALQHRLGHGELAEHFYLKALSL 1221
Score = 45.1 bits (105), Expect = 2e-04
Identities = 81/362 (22%), Positives = 123/362 (33%), Gaps = 74/362 (20%)
Query: 31 GERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFY---LHDYAKALEYHHH 87
G + G + G ++E A+ V E S + + +FY + A+ + YH
Sbjct: 953 GHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRAVQRLCHFYSAVMPSEAQCVIYHEL 1012
Query: 88 DLTLARTIGDQLGEAKASGNLGNTLKVLGN---FDEAIVCCQRHLDISRELNDKVGEARA 144
L+LA + D++ E + + LG + A+ +R L I +L K EA A
Sbjct: 1013 QLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQKKEKEAHA 1072
Query: 145 LYNLGNVYH--------------AKGKSFGCPGPQDVGEFPEEVRDAL-------QAAVD 183
G +Y+ A+ + P E E D + AV
Sbjct: 1073 WLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNLGLELFEAAGDIFFDGAWEREKAVS 1132
Query: 184 FYEEN-LSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAER 242
FY + L L G+R A+ R L L ++ + L ++ GD+ ER
Sbjct: 1133 FYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGLEFAHMALALSITLGDRLNER 1192
Query: 243 RAYSNLGNAYIFLGEFETASEYYKKTLLLARQ-------------------------LKD 277
AY L LG E A +Y K L L LKD
Sbjct: 1193 VAYHRLAALQHRLGHGELAEHFYLKALSLCNSPLEFDEETLYYVKVYLVLGDIIFYDLKD 1252
Query: 278 RAVEA-------QSCYSLGNT--------------YTLLQDYEKAIDYHLKHLAIAQELN 316
A + LGN + L D EK++ ++ K A ELN
Sbjct: 1253 PFDAAGYYQLALAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQKARTFATELN 1312
Query: 317 DR 318
R
Sbjct: 1313 VR 1314
>gi|38488692 SH3 domain and tetratricopeptide repeats 2 [Homo sapiens]
Length = 1288
Score = 47.8 bits (112), Expect = 3e-05
Identities = 72/341 (21%), Positives = 131/341 (38%), Gaps = 31/341 (9%)
Query: 43 GVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLH---DYAKALEYHHHDLTLARTIGDQL 99
G+ +E A+ G S + + +FY + + YH H L LA+ + D+
Sbjct: 939 GLLCYEMALLFGLRHRHLKSQLQATKSLCHFYSSVSPNPEACITYHEHWLALAQQLRDRE 998
Query: 100 GEAKASGNLGNTLKVLG---NFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKG 156
E + +LG + L + ++ C + L I +L + A A G +++
Sbjct: 999 MEGRLLESLGQLYRNLNTARSLRRSLTCIKESLRIFIDLGETDKAAEAWLGAGRLHYLMQ 1058
Query: 157 KSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGN-LGNTHYLL 215
+ E V LQAA+ ++ + AL G F N + H+ +
Sbjct: 1059 ED-------------ELVELCLQAAIQTALKSEEPLLALKLYEEAGDVFFNGTRHRHHAV 1105
Query: 216 GNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQL 275
+R + +RL + E R ++ L I L +E A E+ L+
Sbjct: 1106 EYYRAGAVPLARRLKAVR------TELRIFNKLTELQISLEGYEKALEFATLAARLSTVT 1159
Query: 276 KDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIA----QELNDRIGEGRACWSLGN- 330
D+ E + + L Y L YE A D +LK L++ Q + + + + LG
Sbjct: 1160 GDQRQELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCPPWLQSPKEALYYAKVYYRLGRL 1219
Query: 331 AYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDL 371
+ L + A + L + +GD+ + T R L ++
Sbjct: 1220 TFCQLKDAHDATEYFLLALAAAVLLGDEELQDTIRSRLDNI 1260
Score = 41.2 bits (95), Expect = 0.003
Identities = 52/218 (23%), Positives = 85/218 (38%), Gaps = 24/218 (11%)
Query: 126 QRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFY 185
++ LD+ L + E +L G +Y+ G + G + A Y
Sbjct: 813 KKALDVLEPLLCSLKETESLTQRGVIYNLLGLALQGEG-------------RVNRAAKSY 859
Query: 186 EENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAY 245
L+ +GD Q A NLG H L ++ A L + + + A +
Sbjct: 860 LRALNRAQEVGDVHNQAVAMANLG--HLSLKSWAQHP-ARNYLLQAVRLYCELQASKETD 916
Query: 246 SNLGNAYIFLGEFETASEY-------YKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQ-D 297
L +++L + + Y+ LL + + + Q+ SL + Y+ + +
Sbjct: 917 MELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLCHFYSSVSPN 976
Query: 298 YEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTAL 335
E I YH LA+AQ+L DR EGR SLG Y L
Sbjct: 977 PEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNL 1014
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 45.8 bits (107), Expect = 1e-04
Identities = 85/392 (21%), Positives = 136/392 (34%), Gaps = 72/392 (18%)
Query: 61 LSAIYSQLGNAYFYLHDYAKALEYHHHDLTLAR--------------TIGDQLGEAKA-- 104
L+ YS LGN Y +A+E++ H L L GD G +A
Sbjct: 78 LAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYV 137
Query: 105 ------------SGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVY 152
+LGN LK LG +EA C + ++ A A NLG V+
Sbjct: 138 SALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNF------AVAWSNLGCVF 191
Query: 153 HAKGKSFGCPGPQDVGEFPEEVR-------------DALQAAVDFYEENLSLVTALGDRA 199
+A+G+ + + F + V + L+ A F + + AL
Sbjct: 192 NAQGEIW-----LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSP 246
Query: 200 AQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFE 259
GNL +Y G A+ + + + + F D AY NL NA G
Sbjct: 247 NHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD------AYCNLANALKEKGSVA 300
Query: 260 TASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRI 319
A + Y L L A S +L N + E+A+ + K L + E
Sbjct: 301 EAEDCYNTALRLC------PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAH 354
Query: 320 GE-GRACWSLGNAYTALGNHDQAMH----FAEKHLEIS---REVGDKSGELTARLNLSDL 371
G AL ++ +A+ FA+ + + +E+ D G L +
Sbjct: 355 SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQI 414
Query: 372 QMVLGLSYSTNNSIMSENTEIDSSLNGVRPKL 403
++S SI ++ I ++ R L
Sbjct: 415 NPAFADAHSNLASIHKDSGNIPEAIASYRTAL 446
Score = 34.3 bits (77), Expect = 0.39
Identities = 38/163 (23%), Positives = 66/163 (40%), Gaps = 31/163 (19%)
Query: 36 KSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTI 95
+ G+ V + A++V E +A +S L + +AL ++ + ++ T
Sbjct: 329 EQGNIEEAVRLYRKALEVFPE----FAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF 384
Query: 96 GDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAK 155
D A N+GNTLK + + A+ C R + I+ D A NL +++
Sbjct: 385 AD------AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFAD------AHSNLASIH--- 429
Query: 156 GKSFGCPGPQDVGEFPEEV---RDALQAAVDFYEENLSLVTAL 195
+D G PE + R AL+ DF + +L L
Sbjct: 430 ---------KDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCL 463
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 45.8 bits (107), Expect = 1e-04
Identities = 85/392 (21%), Positives = 136/392 (34%), Gaps = 72/392 (18%)
Query: 61 LSAIYSQLGNAYFYLHDYAKALEYHHHDLTLAR--------------TIGDQLGEAKA-- 104
L+ YS LGN Y +A+E++ H L L GD G +A
Sbjct: 88 LAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYV 147
Query: 105 ------------SGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVY 152
+LGN LK LG +EA C + ++ A A NLG V+
Sbjct: 148 SALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNF------AVAWSNLGCVF 201
Query: 153 HAKGKSFGCPGPQDVGEFPEEVR-------------DALQAAVDFYEENLSLVTALGDRA 199
+A+G+ + + F + V + L+ A F + + AL
Sbjct: 202 NAQGEIW-----LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSP 256
Query: 200 AQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFE 259
GNL +Y G A+ + + + + F D AY NL NA G
Sbjct: 257 NHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD------AYCNLANALKEKGSVA 310
Query: 260 TASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRI 319
A + Y L L A S +L N + E+A+ + K L + E
Sbjct: 311 EAEDCYNTALRLC------PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAH 364
Query: 320 GE-GRACWSLGNAYTALGNHDQAMH----FAEKHLEIS---REVGDKSGELTARLNLSDL 371
G AL ++ +A+ FA+ + + +E+ D G L +
Sbjct: 365 SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQI 424
Query: 372 QMVLGLSYSTNNSIMSENTEIDSSLNGVRPKL 403
++S SI ++ I ++ R L
Sbjct: 425 NPAFADAHSNLASIHKDSGNIPEAIASYRTAL 456
Score = 34.3 bits (77), Expect = 0.39
Identities = 38/163 (23%), Positives = 66/163 (40%), Gaps = 31/163 (19%)
Query: 36 KSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTI 95
+ G+ V + A++V E +A +S L + +AL ++ + ++ T
Sbjct: 339 EQGNIEEAVRLYRKALEVFPE----FAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF 394
Query: 96 GDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAK 155
D A N+GNTLK + + A+ C R + I+ D A NL +++
Sbjct: 395 AD------AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFAD------AHSNLASIH--- 439
Query: 156 GKSFGCPGPQDVGEFPEEV---RDALQAAVDFYEENLSLVTAL 195
+D G PE + R AL+ DF + +L L
Sbjct: 440 ---------KDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCL 473
>gi|11545817 G-protein signaling modulator 3 (AGS3-like, C. elegans)
[Homo sapiens]
Length = 160
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/132 (31%), Positives = 61/132 (46%), Gaps = 18/132 (13%)
Query: 520 STTTSSTPP---KMMLKTSSVPVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQ 576
S S PP L S ++S T+ LDL+A +QSRRL++QRA+F Q
Sbjct: 35 SAPPSPPPPGTRHTALGPRSASLLSLQTELLLDLVAEAQSRRLEEQRATFYT------PQ 88
Query: 577 NSQSVLSHLMTNDNKEADEDFFDILVKCQGSRLDDQRCAPPPATTKGPTVPDEDFFSLIL 636
N S+ + E E + ++ Q R++ QR PP ++ L+L
Sbjct: 89 NPSSLAPAPLR--PLEDREQLYSTILSHQCQRMEAQRSEPPLPP------GGQELLELLL 140
Query: 637 RSQ-GKRMDEQR 647
R Q G RM+EQR
Sbjct: 141 RVQGGGRMEEQR 152
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 45.1 bits (105), Expect = 2e-04
Identities = 88/415 (21%), Positives = 154/415 (37%), Gaps = 94/415 (22%)
Query: 48 EAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGN 107
E+ + G + L + ++ N +L D + E +H T + A A N
Sbjct: 361 ESLFRSGVQTLPHNAKVHYNYAN---FLKDQGRNKEAIYHYRTALKLYPRH---ASALNN 414
Query: 108 LGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDV 167
LG + + EA + QR L + + N RAL+NLGN+ ++ K
Sbjct: 415 LGTLTR---DTAEAKMYYQRALQLHPQHN------RALFNLGNLLKSQEKK--------- 456
Query: 168 GEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRA-------FGNLGNTHYLLGNFR- 219
E ++D+++ +F + SL + L ++ A N ++ L N+
Sbjct: 457 EEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGV 516
Query: 220 --------DAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLL 271
+ +AH Q+ + + A NLG Y LGE A E+YK+ L +
Sbjct: 517 FLVDTGLPEKAVAHYQQAIKLSP-----SHHVAMVNLGRLYRSLGENSMAEEWYKRALQV 571
Query: 272 ARQLKDRAVEAQSCYSLGNTYTLLQDYEKAI----DYHLKHLAIAQEL------------ 315
A + + + Y+ G LQ Y++A LA+AQ L
Sbjct: 572 AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKM 631
Query: 316 -NDRIGEGRACWS----LGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSD 370
N + E C L Y+ NHD+A+ +K L+ L D
Sbjct: 632 TNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQ---------------LKPKD 676
Query: 371 LQMVLGLSYSTNNSIMSENTEIDSSLNGVRPKLGRRHSMENMELMKLTPEKVQNW 425
+++ L ++ N + +N +D + R ++L P++ Q W
Sbjct: 677 PKVISELFFTKGNQLREQNL-LDKAFESYR------------VAVQLNPDQAQAW 718
>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
sapiens]
Length = 833
Score = 43.5 bits (101), Expect = 6e-04
Identities = 33/125 (26%), Positives = 59/125 (47%), Gaps = 15/125 (12%)
Query: 244 AYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAID 303
A +N GN G++E A+E+YK+ L++ + ++ Y++G TY L ++A+D
Sbjct: 495 ALTNKGNTVFANGDYEKAAEFYKEA------LRNDSSCTEALYNIGLTYEKLNRLDEALD 548
Query: 304 YHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEI---SREVGDKSG 360
LK AI + + + N Y + N QA+ + + + + +V K G
Sbjct: 549 CFLKLHAILR------NSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLG 602
Query: 361 ELTAR 365
EL R
Sbjct: 603 ELYDR 607
Score = 33.9 bits (76), Expect = 0.51
Identities = 62/297 (20%), Positives = 113/297 (38%), Gaps = 39/297 (13%)
Query: 68 LGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQR 127
+GN Y +Y+KA++++ L ++ Q+ K N+G T G + +AI +
Sbjct: 248 MGNIYLKQRNYSKAIKFYRMALDQVPSVNKQM-RIKIMQNIGVTFIQAGQYSDAINSYEH 306
Query: 128 HLDISRELNDKVGEARALYNLGNVYHAKG------KSFGCPGPQDVGEFPEEV-RDALQA 180
+ ++ L +A YNL Y A G K+F Q + P E+ D +
Sbjct: 307 IMSMAPNL-------KAGYNLTICYFAIGDREKMKKAF-----QKLITVPLEIDEDKYIS 354
Query: 181 AVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAA 240
D NL D Q Y++ + + E ++ +
Sbjct: 355 PSDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVV 414
Query: 241 ERRAYSNLGN--------AYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTY 292
+ Y L N Y+ ++ A E +L + KD V++ + +L Y
Sbjct: 415 KASQYVELANDLEINKAVTYLRQKDYNQAVE-----ILKVLEKKDSRVKSAAATNLSALY 469
Query: 293 TLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHL 349
+ +D+ +A Y A +DR A + GN A G++++A F ++ L
Sbjct: 470 YMGKDFAQASSY-----ADIAVNSDRYNPA-ALTNKGNTVFANGDYEKAAEFYKEAL 520
Score = 32.7 bits (73), Expect = 1.1
Identities = 26/90 (28%), Positives = 37/90 (41%), Gaps = 12/90 (13%)
Query: 63 AIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAI 122
A + GN F DY KA E++ L + +A N+G T + L DEA+
Sbjct: 494 AALTNKGNTVFANGDYEKAAEFYKEALR------NDSSCTEALYNIGLTYEKLNRLDEAL 547
Query: 123 VCCQRHLDISRELNDKVGEARALYNLGNVY 152
C + I R A LY + N+Y
Sbjct: 548 DCFLKLHAILR------NSAEVLYQIANIY 571
>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
sapiens]
Length = 824
Score = 43.5 bits (101), Expect = 6e-04
Identities = 33/125 (26%), Positives = 59/125 (47%), Gaps = 15/125 (12%)
Query: 244 AYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAID 303
A +N GN G++E A+E+YK+ L++ + ++ Y++G TY L ++A+D
Sbjct: 486 ALTNKGNTVFANGDYEKAAEFYKEA------LRNDSSCTEALYNIGLTYEKLNRLDEALD 539
Query: 304 YHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEI---SREVGDKSG 360
LK AI + + + N Y + N QA+ + + + + +V K G
Sbjct: 540 CFLKLHAILR------NSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLG 593
Query: 361 ELTAR 365
EL R
Sbjct: 594 ELYDR 598
Score = 33.9 bits (76), Expect = 0.51
Identities = 62/297 (20%), Positives = 113/297 (38%), Gaps = 39/297 (13%)
Query: 68 LGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQR 127
+GN Y +Y+KA++++ L ++ Q+ K N+G T G + +AI +
Sbjct: 239 MGNIYLKQRNYSKAIKFYRMALDQVPSVNKQM-RIKIMQNIGVTFIQAGQYSDAINSYEH 297
Query: 128 HLDISRELNDKVGEARALYNLGNVYHAKG------KSFGCPGPQDVGEFPEEV-RDALQA 180
+ ++ L +A YNL Y A G K+F Q + P E+ D +
Sbjct: 298 IMSMAPNL-------KAGYNLTICYFAIGDREKMKKAF-----QKLITVPLEIDEDKYIS 345
Query: 181 AVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAA 240
D NL D Q Y++ + + E ++ +
Sbjct: 346 PSDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVV 405
Query: 241 ERRAYSNLGN--------AYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTY 292
+ Y L N Y+ ++ A E +L + KD V++ + +L Y
Sbjct: 406 KASQYVELANDLEINKAVTYLRQKDYNQAVE-----ILKVLEKKDSRVKSAAATNLSALY 460
Query: 293 TLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHL 349
+ +D+ +A Y A +DR A + GN A G++++A F ++ L
Sbjct: 461 YMGKDFAQASSY-----ADIAVNSDRYNPA-ALTNKGNTVFANGDYEKAAEFYKEAL 511
Score = 32.7 bits (73), Expect = 1.1
Identities = 26/90 (28%), Positives = 37/90 (41%), Gaps = 12/90 (13%)
Query: 63 AIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAI 122
A + GN F DY KA E++ L + +A N+G T + L DEA+
Sbjct: 485 AALTNKGNTVFANGDYEKAAEFYKEALR------NDSSCTEALYNIGLTYEKLNRLDEAL 538
Query: 123 VCCQRHLDISRELNDKVGEARALYNLGNVY 152
C + I R A LY + N+Y
Sbjct: 539 DCFLKLHAILR------NSAEVLYQIANIY 562
>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
sapiens]
Length = 807
Score = 38.5 bits (88), Expect = 0.021
Identities = 26/95 (27%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 209 GNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKT 268
G T + G ++A+ + ++ L +F D AY +LG AY LG FE A+E ++K
Sbjct: 237 GLTFFHRGLLKEAIESFKEALKQKVDFID------AYKSLGQAYRELGNFEAATESFQKA 290
Query: 269 LLL-ARQLKDRAVEAQSCYSLGNTYTLLQDYEKAI 302
LLL ++ + Y G+ L+++++ +
Sbjct: 291 LLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCL 325
>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
sapiens]
Length = 860
Score = 38.5 bits (88), Expect = 0.021
Identities = 26/95 (27%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 209 GNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKT 268
G T + G ++A+ + ++ L +F D AY +LG AY LG FE A+E ++K
Sbjct: 290 GLTFFHRGLLKEAIESFKEALKQKVDFID------AYKSLGQAYRELGNFEAATESFQKA 343
Query: 269 LLL-ARQLKDRAVEAQSCYSLGNTYTLLQDYEKAI 302
LLL ++ + Y G+ L+++++ +
Sbjct: 344 LLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCL 378
>gi|224809578 RAP1 GTPase activating protein isoform a [Homo
sapiens]
Length = 727
Score = 38.1 bits (87), Expect = 0.027
Identities = 16/33 (48%), Positives = 24/33 (72%), Gaps = 1/33 (3%)
Query: 596 DFFDILVKCQGSRLDDQRCA-PPPATTKGPTVP 627
D F+++ K QGSR+D+QRC+ PPP T+ +P
Sbjct: 61 DLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIP 93
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 37.0 bits (84), Expect = 0.061
Identities = 56/224 (25%), Positives = 81/224 (36%), Gaps = 50/224 (22%)
Query: 96 GDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAK 155
G ++ AKA GNLGN LK EA + L + D LYNLG +
Sbjct: 487 GIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMAD------MLYNLGLLL--- 537
Query: 156 GKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLL 215
Q+ F E A+ +Y+ A+G R A+ N G
Sbjct: 538 ---------QENSRFAE--------ALHYYK------LAIGSRPTLASAYLNTGIILMNQ 574
Query: 216 GNFRDAVIAHEQRLLIAKEFGD---------KAAERRAYSNLGNAYIFLGEFETASEYYK 266
G +A + L E D K++ NLG Y G +E A YK
Sbjct: 575 GRTEEA----RRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYK 630
Query: 267 KTLLLARQLKDRAVEAQSCYS-LGNTYTLLQDYEKAIDYHLKHL 309
+ + Q R QS Y+ +G Y L +A ++++ L
Sbjct: 631 EAI----QKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESL 670
>gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens]
Length = 1316
Score = 37.0 bits (84), Expect = 0.061
Identities = 39/164 (23%), Positives = 69/164 (42%), Gaps = 17/164 (10%)
Query: 195 LGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIF 254
+ +R A R+F LG+ + + +A++A+EQ L + G A S +G A I
Sbjct: 715 IAERMANPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLA------SKMGKALIK 768
Query: 255 LGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKA---IDYHLKHLAI 311
+ A YY+ L + + CY L L+ Y+KA + + L H +
Sbjct: 769 THNYSMAITYYEAALKTGQ-------KNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPV 821
Query: 312 AQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREV 355
EL+ + +GR L Y+ + A+ ++ E+ V
Sbjct: 822 -NELSALMEDGRCQVLLAKVYSKMEKLGDAITALQQARELQARV 864
>gi|38569411 AP1 gamma subunit binding protein 1 isoform 2 [Homo
sapiens]
Length = 1302
Score = 35.8 bits (81), Expect = 0.13
Identities = 18/41 (43%), Positives = 22/41 (53%)
Query: 539 VVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQ 579
VV P D+F D +S+S LDD + F LP T NSQ
Sbjct: 450 VVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQ 490
>gi|38569409 AP1 gamma subunit binding protein 1 isoform 1 [Homo
sapiens]
Length = 1314
Score = 35.8 bits (81), Expect = 0.13
Identities = 18/41 (43%), Positives = 22/41 (53%)
Query: 539 VVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQ 579
VV P D+F D +S+S LDD + F LP T NSQ
Sbjct: 450 VVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQ 490
>gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens]
Length = 705
Score = 35.4 bits (80), Expect = 0.18
Identities = 37/141 (26%), Positives = 60/141 (42%), Gaps = 14/141 (9%)
Query: 2 EENLISMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAV---QVGTEDL 58
E L S+ +D + R E L AL+ + G+ +E A+ G E L
Sbjct: 82 EAFLASVEKDAKERAKRRRENKVLADALK-----EKGNEAFAEGNYETAILRYSEGLEKL 136
Query: 59 KTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNF 118
K + +Y+ AY L DY KAL D A ++ KA ++G L N+
Sbjct: 137 KDMKVLYTNRAQAYMKLEDYEKALV----DCEWALKCDEKC--TKAYFHMGKANLALKNY 190
Query: 119 DEAIVCCQRHLDISRELNDKV 139
+ C ++ L+I+ +L +V
Sbjct: 191 SVSRECYKKILEINPKLQTQV 211
>gi|21264343 scaffold attachment factor B [Homo sapiens]
Length = 915
Score = 35.0 bits (79), Expect = 0.23
Identities = 43/166 (25%), Positives = 73/166 (43%), Gaps = 17/166 (10%)
Query: 431 AKQKPLIAKPSAKLLFVNRLKGKKYKTNSSTKVLQDASNSIDHRIPNSQRKISADTIGDE 490
AK +P+ K S K GKK K+++S D S ++ R RK A GD+
Sbjct: 482 AKNEPVGKKTSDK----RDSDGKKEKSSNS-----DRSTNLK-RDDKCDRKDDAKK-GDD 530
Query: 491 GFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSSTPPKMMLKTSSVPVVSPNTDEFLDL 550
G S +S DDQ+ E++ T S + + +M K+ VPV+S T +
Sbjct: 531 G-----SGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKER 585
Query: 551 LASSQSRR-LDDQRASFSNLPGLRLTQNSQSVLSHLMTNDNKEADE 595
+ SQ R+ ++ S + ++ + S+ SH + E ++
Sbjct: 586 ASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQ 631
>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
protein) [Homo sapiens]
Length = 543
Score = 34.7 bits (78), Expect = 0.30
Identities = 18/62 (29%), Positives = 32/62 (51%), Gaps = 3/62 (4%)
Query: 36 KSGDCRAGVSFFEAAVQVGTE---DLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLA 92
+ GD E A++VG E D + ++ Y+++GN+YF Y A+ +++ L
Sbjct: 271 EKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEH 330
Query: 93 RT 94
RT
Sbjct: 331 RT 332
Score = 30.8 bits (68), Expect = 4.3
Identities = 51/225 (22%), Positives = 88/225 (39%), Gaps = 50/225 (22%)
Query: 101 EAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFG 160
+A LGN +FD A+ +H D ++EL+ + N VY KG
Sbjct: 224 QALKEKELGNDAYKKKDFDTAL----KHYDKAKELDPT--NMTYITNQAAVYFEKGDYNK 277
Query: 161 CPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRD 220
C R+ + A++ EN D +A+ +GN+++ ++D
Sbjct: 278 C-------------RELCEKAIEVGRENRE------DYRQIAKAYARIGNSYFKEEKYKD 318
Query: 221 AVIAHEQRLL------IAKEFGD-----KAAERRAY---------SNLGNAYIFLGEFET 260
A+ + + L + K+ K ER AY N GN G++
Sbjct: 319 AIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQ 378
Query: 261 ASEYYKKTLLLARQLKDRAVEAQ--SCYSLGNTYTL-LQDYEKAI 302
A ++Y T + R KD + + +CY+ + L L+D E+ I
Sbjct: 379 AMKHY--TEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECI 421
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,351,092
Number of Sequences: 37866
Number of extensions: 1041876
Number of successful extensions: 3539
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 3141
Number of HSP's gapped (non-prelim): 230
length of query: 684
length of database: 18,247,518
effective HSP length: 109
effective length of query: 575
effective length of database: 14,120,124
effective search space: 8119071300
effective search space used: 8119071300
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.