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Search of human proteins with 16445438
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16445438 bromodomain and WD repeat domain containing 1
isoform B [Homo sapiens]
(2269 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16445438 bromodomain and WD repeat domain containing 1 isofor... 4583 0.0
gi|16445436 bromodomain and WD repeat domain containing 1 isofor... 4424 0.0
gi|153791630 bromodomain and WD repeat domain containing 3 [Homo... 1882 0.0
gi|34996489 pleckstrin homology domain interacting protein [Homo... 1826 0.0
gi|55956930 bromodomain and WD repeat domain containing 1 isofor... 232 3e-60
gi|32189425 WD repeat domain 69 [Homo sapiens] 116 2e-25
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 103 1e-21
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 103 1e-21
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 103 1e-21
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 103 1e-21
gi|23199987 WD repeat domain 5B [Homo sapiens] 103 1e-21
gi|16554629 WD repeat domain 5 [Homo sapiens] 99 6e-20
gi|16554627 WD repeat domain 5 [Homo sapiens] 99 6e-20
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 98 8e-20
gi|113865883 WD repeat domain 38 [Homo sapiens] 98 8e-20
gi|21071067 TBP-associated factor 5 [Homo sapiens] 94 2e-18
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 93 3e-18
gi|19913367 transducin beta-like 1Y [Homo sapiens] 92 4e-18
gi|19913365 transducin beta-like 1Y [Homo sapiens] 92 4e-18
gi|15150805 transducin beta-like 1Y [Homo sapiens] 92 4e-18
gi|26665869 WD repeat domain 51B [Homo sapiens] 91 1e-17
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 90 2e-17
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 88 8e-17
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 88 8e-17
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 84 2e-15
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 84 2e-15
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 84 2e-15
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 84 2e-15
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 83 3e-15
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 81 1e-14
>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
[Homo sapiens]
Length = 2269
Score = 4583 bits (11887), Expect = 0.0
Identities = 2269/2269 (100%), Positives = 2269/2269 (100%)
Query: 1 MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN 60
MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN
Sbjct: 1 MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN 60
Query: 61 RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRH 120
RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRH
Sbjct: 61 RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRH 120
Query: 121 TVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR 180
TVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR
Sbjct: 121 TVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR 180
Query: 181 RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN 240
RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN
Sbjct: 181 RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN 240
Query: 241 TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCF 300
TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCF
Sbjct: 241 TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCF 300
Query: 301 WQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK 360
WQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK
Sbjct: 301 WQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK 360
Query: 361 IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSE 420
IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSE
Sbjct: 361 IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSE 420
Query: 421 EERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFD 480
EERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFD
Sbjct: 421 EERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFD 480
Query: 481 SRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL 540
SRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL
Sbjct: 481 SRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL 540
Query: 541 LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPH 600
LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPH
Sbjct: 541 LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPH 600
Query: 601 PTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIR 660
PTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIR
Sbjct: 601 PTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIR 660
Query: 661 QLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH 720
QLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH
Sbjct: 661 QLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH 720
Query: 721 QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQL 780
QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQL
Sbjct: 721 QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQL 780
Query: 781 SHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSS 840
SHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSS
Sbjct: 781 SHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSS 840
Query: 841 EEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIS 900
EEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIS
Sbjct: 841 EEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIS 900
Query: 901 TENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQ 960
TENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQ
Sbjct: 901 TENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQ 960
Query: 961 MGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLC 1020
MGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLC
Sbjct: 961 MGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLC 1020
Query: 1021 CLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDA 1080
CLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDA
Sbjct: 1021 CLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDA 1080
Query: 1081 WWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISV 1140
WWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISV
Sbjct: 1081 WWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISV 1140
Query: 1141 TTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTV 1200
TTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTV
Sbjct: 1141 TTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTV 1200
Query: 1201 VAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKF 1260
VAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKF
Sbjct: 1201 VAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKF 1260
Query: 1261 IKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKK 1320
IKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKK
Sbjct: 1261 IKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKK 1320
Query: 1321 QCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCK 1380
QCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCK
Sbjct: 1321 QCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCK 1380
Query: 1381 DIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQ 1440
DIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQ
Sbjct: 1381 DIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQ 1440
Query: 1441 RQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGV 1500
RQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGV
Sbjct: 1441 RQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGV 1500
Query: 1501 TSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARES 1560
TSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARES
Sbjct: 1501 TSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARES 1560
Query: 1561 SSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKA 1620
SSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKA
Sbjct: 1561 SSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKA 1620
Query: 1621 RAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSED 1680
RAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSED
Sbjct: 1621 RAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSED 1680
Query: 1681 EQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKS 1740
EQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKS
Sbjct: 1681 EQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKS 1740
Query: 1741 HTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPGRSGG 1800
HTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPGRSGG
Sbjct: 1741 HTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPGRSGG 1800
Query: 1801 RKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCS 1860
RKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCS
Sbjct: 1801 RKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCS 1860
Query: 1861 SDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKA 1920
SDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKA
Sbjct: 1861 SDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKA 1920
Query: 1921 RTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCE 1980
RTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCE
Sbjct: 1921 RTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCE 1980
Query: 1981 GSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDA 2040
GSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDA
Sbjct: 1981 GSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDA 2040
Query: 2041 PSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRR 2100
PSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRR
Sbjct: 2041 PSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRR 2100
Query: 2101 LRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDL 2160
LRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDL
Sbjct: 2101 LRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDL 2160
Query: 2161 GSVTESDIDCTDNTKTKRRKTKGKAKVVRKGKTFTANISKTVRRQRQSKRPRLSVDDNDW 2220
GSVTESDIDCTDNTKTKRRKTKGKAKVVRKGKTFTANISKTVRRQRQSKRPRLSVDDNDW
Sbjct: 2161 GSVTESDIDCTDNTKTKRRKTKGKAKVVRKGKTFTANISKTVRRQRQSKRPRLSVDDNDW 2220
Query: 2221 EDLDYAKSKRVLRRSKIKTRNQGRRTVRYHDGDDDRSLENVLDFNGCTL 2269
EDLDYAKSKRVLRRSKIKTRNQGRRTVRYHDGDDDRSLENVLDFNGCTL
Sbjct: 2221 EDLDYAKSKRVLRRSKIKTRNQGRRTVRYHDGDDDRSLENVLDFNGCTL 2269
>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
[Homo sapiens]
Length = 2320
Score = 4424 bits (11473), Expect = 0.0
Identities = 2190/2190 (100%), Positives = 2190/2190 (100%)
Query: 1 MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN 60
MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN
Sbjct: 1 MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN 60
Query: 61 RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRH 120
RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRH
Sbjct: 61 RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRH 120
Query: 121 TVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR 180
TVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR
Sbjct: 121 TVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR 180
Query: 181 RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN 240
RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN
Sbjct: 181 RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN 240
Query: 241 TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCF 300
TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCF
Sbjct: 241 TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCF 300
Query: 301 WQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK 360
WQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK
Sbjct: 301 WQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK 360
Query: 361 IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSE 420
IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSE
Sbjct: 361 IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSE 420
Query: 421 EERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFD 480
EERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFD
Sbjct: 421 EERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFD 480
Query: 481 SRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL 540
SRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL
Sbjct: 481 SRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL 540
Query: 541 LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPH 600
LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPH
Sbjct: 541 LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPH 600
Query: 601 PTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIR 660
PTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIR
Sbjct: 601 PTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIR 660
Query: 661 QLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH 720
QLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH
Sbjct: 661 QLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH 720
Query: 721 QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQL 780
QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQL
Sbjct: 721 QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQL 780
Query: 781 SHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSS 840
SHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSS
Sbjct: 781 SHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSS 840
Query: 841 EEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIS 900
EEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIS
Sbjct: 841 EEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIS 900
Query: 901 TENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQ 960
TENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQ
Sbjct: 901 TENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQ 960
Query: 961 MGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLC 1020
MGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLC
Sbjct: 961 MGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLC 1020
Query: 1021 CLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDA 1080
CLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDA
Sbjct: 1021 CLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDA 1080
Query: 1081 WWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISV 1140
WWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISV
Sbjct: 1081 WWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISV 1140
Query: 1141 TTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTV 1200
TTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTV
Sbjct: 1141 TTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTV 1200
Query: 1201 VAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKF 1260
VAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKF
Sbjct: 1201 VAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKF 1260
Query: 1261 IKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKK 1320
IKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKK
Sbjct: 1261 IKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKK 1320
Query: 1321 QCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCK 1380
QCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCK
Sbjct: 1321 QCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCK 1380
Query: 1381 DIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQ 1440
DIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQ
Sbjct: 1381 DIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQ 1440
Query: 1441 RQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGV 1500
RQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGV
Sbjct: 1441 RQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGV 1500
Query: 1501 TSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARES 1560
TSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARES
Sbjct: 1501 TSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARES 1560
Query: 1561 SSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKA 1620
SSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKA
Sbjct: 1561 SSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKA 1620
Query: 1621 RAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSED 1680
RAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSED
Sbjct: 1621 RAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSED 1680
Query: 1681 EQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKS 1740
EQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKS
Sbjct: 1681 EQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKS 1740
Query: 1741 HTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPGRSGG 1800
HTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPGRSGG
Sbjct: 1741 HTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPGRSGG 1800
Query: 1801 RKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCS 1860
RKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCS
Sbjct: 1801 RKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCS 1860
Query: 1861 SDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKA 1920
SDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKA
Sbjct: 1861 SDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKA 1920
Query: 1921 RTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCE 1980
RTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCE
Sbjct: 1921 RTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCE 1980
Query: 1981 GSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDA 2040
GSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDA
Sbjct: 1981 GSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDA 2040
Query: 2041 PSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRR 2100
PSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRR
Sbjct: 2041 PSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRR 2100
Query: 2101 LRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDL 2160
LRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDL
Sbjct: 2101 LRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDL 2160
Query: 2161 GSVTESDIDCTDNTKTKRRKTKGKAKVVRK 2190
GSVTESDIDCTDNTKTKRRKTKGKAKVVRK
Sbjct: 2161 GSVTESDIDCTDNTKTKRRKTKGKAKVVRK 2190
Score = 170 bits (430), Expect = 2e-41
Identities = 189/670 (28%), Positives = 294/670 (43%), Gaps = 84/670 (12%)
Query: 1328 LIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFS 1387
L+ ED + + ++ E D ++ ++ N DS E D+R+
Sbjct: 1674 LLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESE--SDLRVARK 1731
Query: 1388 N--AKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQRQNCK 1445
N A Y + + + L++ + EE K SD C
Sbjct: 1732 NWHANGYKSHTPAPSKTKFLKIESS-EEDSKSHDSDHA--------------------CN 1770
Query: 1446 GDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGVTSGDS 1505
+ P+ S++ LK + + + P G +T HK ++ DS
Sbjct: 1771 RTAGPSTSVQKLKAESISEEADSEPGRSGGRKYNTF--------HKNASFFKKTKILSDS 1822
Query: 1506 SDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSSRSG 1565
DS E +++R + + + +L + + SS+ E+ S
Sbjct: 1823 EDS----ESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCSSDHGCETDL---DSDDDK 1875
Query: 1566 LSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKARAGNN 1625
+ + +N S NG RK +RKRV SDSD++ + KAR G
Sbjct: 1876 IEKPNNFM----------KDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKARTGLL 1925
Query: 1626 RKVLRKCAAVAANKIKLMSDVE----ENSSSESVCSGRKLPHRNASAVARKKLLHNSEDE 1681
R + R+CAA AANKIKLMSDVE EN + S +GRK P A A+KKL S+ E
Sbjct: 1926 R-ITRRCAATAANKIKLMSDVEDVSLENVHTRSK-NGRKKPLHLACTTAKKKL---SDCE 1980
Query: 1682 QSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKSH 1741
S+ E+ E+ E + P S + + ++ N DS+SE L K+ H N +K
Sbjct: 1981 GSVHCEVPSEQYACEGKP-PDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHK-- 2037
Query: 1742 TPAPSKTKFLKIESSEEDSKSHDSDHACNRT-AGPSTSVQKLKAESISE-EADSEPGRSG 1799
APSK K + SS EDSKSH +RT + ST QK AE+ E E + R
Sbjct: 2038 IDAPSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWN 2097
Query: 1800 GRKYNTFHKNASFFKKTKILSDSEDSESEE--QDREDGKCHKMEMNPISGNLNCDPIAMS 1857
GR+ T+ K F KTK++ DS+++ +E + R + ++++ +GN P S
Sbjct: 2098 GRRLRTYGKAP--FSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSS 2155
Query: 1858 QCSSDHGC--ETDLDSDDDKIEKPNN-------FMKDSASQDNGLSRKISRKRVCSSDSD 1908
+ SSD G E+D+D D+ K K+ +D + K+ R C +
Sbjct: 2156 K-SSDLGSVTESDIDCTDNTKTKRRKTKGKAKVVRKEFVPRDREPNTKV---RTCMHNQK 2211
Query: 1909 SSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDV--SLENVHTRSKNGRKKPLH 1966
++Q+ ++ KA+ ++ RRCA AANKIK+MS++++ ENV R K+ RK P
Sbjct: 2212 DAVQMPSETLKAKMVPEKVPRRCATVAANKIKIMSNLKETISGPENVWIR-KSSRKLPHR 2270
Query: 1967 LACTTAKKKL 1976
A AKKKL
Sbjct: 2271 NASAAAKKKL 2280
Score = 84.3 bits (207), Expect = 1e-15
Identities = 66/200 (33%), Positives = 98/200 (49%), Gaps = 17/200 (8%)
Query: 1504 DSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSSR 1563
DS ++AE +RKR+ P +SE+ SS +S ++ +++
Sbjct: 2117 DSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTDNTKT 2176
Query: 1564 SGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKARAG 1623
+V R R P T+ R + + + E LKA+
Sbjct: 2177 KRRKTKGKAKVVRKEFVPRDREP----------NTKVRTCMHNQKDAVQMPSETLKAKMV 2226
Query: 1624 NNRKVLRKCAAVAANKIKLMSDVEEN-SSSESVC---SGRKLPHRNASAVARKKLLH-NS 1678
KV R+CA VAANKIK+MS+++E S E+V S RKLPHRNASA A+KKLL+
Sbjct: 2227 PE-KVPRRCATVAANKIKIMSNLKETISGPENVWIRKSSRKLPHRNASAAAKKKLLNVYK 2285
Query: 1679 EDEQSLKSEIEEEELKDENQ 1698
ED+ ++ SE E+EL+D N+
Sbjct: 2286 EDDTTINSE-SEKELEDINR 2304
>gi|153791630 bromodomain and WD repeat domain containing 3 [Homo
sapiens]
Length = 1802
Score = 1882 bits (4875), Expect = 0.0
Identities = 966/1653 (58%), Positives = 1187/1653 (71%), Gaps = 101/1653 (6%)
Query: 14 IESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHV 73
IE+ELY+LIAR+L +GPC ++AQVLVQELE++QL+P+RLDWEG EH RS+E+LV +N H+
Sbjct: 8 IEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANAHI 67
Query: 74 APDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHR 133
PD+LL+IC+RIGP+LDKEIP S+ V +LLG GRQSLLR AKDC+ T+W GSAFAALHR
Sbjct: 68 PPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHR 127
Query: 134 GRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVA 193
GRPPE+PVNY PPN+V I +QLTGCS F FP + YQHIKMH+RILGHLS+VYCVA
Sbjct: 128 GRPPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHLSSVYCVA 187
Query: 194 FDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIR 253
FDR+G RIFTGSDDCLVKIW+T +GRLL+TLRGHSAEISDMAVNYENT+IAAGSCDK++R
Sbjct: 188 FDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVR 247
Query: 254 VWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPR 313
VWCLRTCAPVAVLQGH+ SITS+QF P KG+ RY+ STGADGT+CFWQW ++++KF R
Sbjct: 248 VWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDR 307
Query: 314 PLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDS 373
P+KFTE+ RPGVQ+ CSSFS GGMF+ TGSTDHVIR+Y+LG E PEKIAELESHTDKV +
Sbjct: 308 PVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVA 367
Query: 374 IQFCNNGD--RFLSGSRDGTARIWRFEQLEWRSILLDMATRISG-DLSSEEERFMKPKVT 430
+QFCNNGD RF+SGSRDGTARIW+++Q EW+SI+LDMAT+++G +L S E++ K KVT
Sbjct: 368 VQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVT 427
Query: 431 MIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHD 490
M+AW++ D+ V+TAVN+ +LKVWNS TGQLLH L GH DEVFVLE HPFD RI+LSAGHD
Sbjct: 428 MVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHD 487
Query: 491 GSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKP 550
G+IFIWD+ +GTK+++YFNMIEGQGHGAVFDCKFS DG HFACTDSHGHLL+FGFGCSK
Sbjct: 488 GNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKY 547
Query: 551 YEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKYQRLVPG 610
YEKIPDQMFFHTDYRPLIRD+NNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTK+QRLVPG
Sbjct: 548 YEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPG 607
Query: 611 RENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRM 670
REN DE LIPQLGYVA DGEV+EQ+I QTND DE SILDG+IR+LQ++QD R+
Sbjct: 608 RENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDE-----SILDGIIRELQREQDLRL 662
Query: 671 GADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRR-SGQVEGVRQMHQNAPRSQIA 729
++ +P N + R ++DI S PNI LRR S Q+EGVRQMH NAPRSQ+A
Sbjct: 663 -INEGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMA 721
Query: 730 TERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQLSHKSDSVVL 789
TERDL AW RRVVV E+ G+ R E+ R KG+ E +LY + +K+K + ++D
Sbjct: 722 TERDLMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPS 781
Query: 790 VSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSSEEDE--WRS 847
+S +RT R++ Y R S E +S + S Q + SSEEDE S
Sbjct: 782 CGRSLRRTQRKRQHTYQTR--------SNIEHNSQASCQNSGVQEDSDSSSEEDETVGTS 833
Query: 848 DRKSE------SYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIST 901
D E SSSDSSS YSDWTADAGINLQPP R + R+ + CSSS++
Sbjct: 834 DASVEDPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQT-RQTTRKICSSSDE---- 888
Query: 902 ENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQM 961
ENL + R+K+ K+ + KK L + E E+ P WI DT R+SPFVPQM
Sbjct: 889 ENLKSLEERQKKPKQTRKKKGGLVSIAG------EPNEEWFAPQWILDTIPRRSPFVPQM 942
Query: 962 GDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLCC 1021
GDE+IYFRQGHEAY+ AVR++ IY +N K+PW KMDLR+QE VKIVGI+YEVGPPTLCC
Sbjct: 943 GDELIYFRQGHEAYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCC 1002
Query: 1022 LKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDAW 1081
LKLAF+DP +GK+ +SFSI+YHDMPDVIDFLVL QFY+EA++RNWQ DRFRSIIDDAW
Sbjct: 1003 LKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAW 1062
Query: 1082 WFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISVT 1141
WFGTV SQ+P+QP+YPDS FQCY V WDN E EK+SPWDMEPIP+ P+E+GA + V+
Sbjct: 1063 WFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVS 1122
Query: 1142 TDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVV 1201
+EL LLYKPQ GEWG SRDEEC+R+I GI+ LL+LD A+ FA PVDL YP YCTVV
Sbjct: 1123 QEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVV 1182
Query: 1202 AYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFI 1261
AYPTDL TIR RL NRFYRR+SAL+WEVRYIEHNARTFNEP+S I ++AK +TD LL+FI
Sbjct: 1183 AYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFI 1242
Query: 1262 KNQHCTNISELSNTSENDEQNAEDLD--------DSDLPKTSSGRRRVHDGKKSIRATNY 1313
+Q CT+I + N + +E+N+ D + DSD P TSSGR+ G++ N
Sbjct: 1243 GDQSCTDILDTYNKIKAEERNSTDAEEDTEIVDLDSDGPGTSSGRKVKCRGRRQSLKCN- 1301
Query: 1314 VESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYP------------------------- 1348
WKKQCKEL++LI++ EDSEPFRQP DL+ YP
Sbjct: 1302 -PDAWKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSE 1360
Query: 1349 DYRDIIDTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLS 1408
DY+D+IDTP+DF TV+ETL+AGNY SPLEF KD+R IF+N+KAYT NK+S+IYSM LRLS
Sbjct: 1361 DYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLS 1420
Query: 1409 ALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQRQNCKGDSQPNKSIRNLKPKRLKSQ--- 1465
ALFE +K I S++K + ++ R R + R + S K K++K Q
Sbjct: 1421 ALFESHIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKN 1480
Query: 1466 ---TKIIPELVGSPTQSTSSRTA-----YLGTHKTSAGISSG-----VTSGDSSDSAESS 1512
T + SP S S A YL + SS SG+S D ++
Sbjct: 1481 DQNTSVSHARTSSPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAK 1540
Query: 1513 ERRKR----------NRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSS 1562
R R + P+TNG E + L S++ E +E+
Sbjct: 1541 SFRNRVLPVKQDHSLDGPLTNG---DGREPRTGIKRKLLSASEEDENMGGEDKEKKETKE 1597
Query: 1563 RSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGR 1595
+S LS S + + + +++ G S + R
Sbjct: 1598 KSHLSTSESGELGSSLSSESTCGSDSDSESTSR 1630
Score = 39.7 bits (91), Expect = 0.034
Identities = 24/61 (39%), Positives = 34/61 (55%), Gaps = 5/61 (8%)
Query: 2203 RRQRQSKRPRLSVDDNDWEDLDYAKSKRVLRRSKIKTRNQGRRTVRYHDGDDDRSLENVL 2262
R ++KR R++ D+ D S R R +IKTRNQGRRTV Y+D D+ + +
Sbjct: 1718 RGATRAKRARIADDE-----FDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTE 1772
Query: 2263 D 2263
D
Sbjct: 1773 D 1773
Score = 34.7 bits (78), Expect = 1.1
Identities = 46/237 (19%), Positives = 95/237 (40%), Gaps = 21/237 (8%)
Query: 1540 LSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATR 1599
L SS+SS S S + ++ + N V+ R + + PVS A A
Sbjct: 1452 LRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTSSPFSSPVSDA------AEG 1505
Query: 1600 KRVYLSDSDNNSLETGEILK--ARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCS 1657
+YL D + + + +R+GN+ + + +++ +++S + +
Sbjct: 1506 LSLYLLDDEPDGPFSSSSFGGYSRSGNSHDP----GKAKSFRNRVLPVKQDHSLDGPLTN 1561
Query: 1658 GRKLPHRNASAVARKKLLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESEN 1717
G R ++KLL SE+++++ E +E++ E L S S S++
Sbjct: 1562 G---DGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELGSSLSSEST 1618
Query: 1718 RDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAG 1774
S+S+S+ + +G + +KF++ + K H + +T G
Sbjct: 1619 CGSDSDSESTSRTDQDYVDGDHDY------SKFIQTRPKRKLRKQHGNGKRNWKTRG 1669
Score = 32.3 bits (72), Expect = 5.4
Identities = 20/73 (27%), Positives = 37/73 (50%), Gaps = 3/73 (4%)
Query: 1815 KTKILSDSEDSES---EEQDREDGKCHKMEMNPISGNLNCDPIAMSQCSSDHGCETDLDS 1871
K K+LS SE+ E+ E++++++ K SG L + S C SD E+ +
Sbjct: 1572 KRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELGSSLSSESTCGSDSDSESTSRT 1631
Query: 1872 DDDKIEKPNNFMK 1884
D D ++ +++ K
Sbjct: 1632 DQDYVDGDHDYSK 1644
>gi|34996489 pleckstrin homology domain interacting protein [Homo
sapiens]
Length = 1821
Score = 1826 bits (4729), Expect = 0.0
Identities = 941/1676 (56%), Positives = 1172/1676 (69%), Gaps = 89/1676 (5%)
Query: 5 SSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYE 64
S R+ + + SELYFLIAR+L GPC++AAQVL++E+ + +LLP+R DW G EH R+Y+
Sbjct: 2 SCERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQ 61
Query: 65 ELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWK 124
LV +H+APDHLLQIC R+GP+L++EIP S+ V +LLGAGRQSLLRT K C+H VWK
Sbjct: 62 NLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWK 121
Query: 125 GSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILG 184
GSA AALH GRPPE PVNYGSPP++ + ++L G P +YQH+KMH+RILG
Sbjct: 122 GSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILG 181
Query: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
HLS+VYCV FDRTG RIFTGSDDCLVKIW+T +GRLL+TLRGH+AEISDMAVNYENTMIA
Sbjct: 182 HLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIA 241
Query: 245 AGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWD 304
AGSCDK+IRVWCLRTCAP+AVLQGH+ SITSLQFSP+ GS+RY+ STGADGT+CFW WD
Sbjct: 242 AGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWD 301
Query: 305 LESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAEL 364
+LK +PRP KFTE+PRPGVQM+CSSFS GGMFLATGSTDH+IR+YF G PEKI+EL
Sbjct: 302 AGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISEL 361
Query: 365 ESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISG-DLSSEEER 423
E HTDKVDSIQF N +RF+SGSRDGTARIW+F++ EW+SILLDMATR +G +L E++
Sbjct: 362 EFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDK 421
Query: 424 FMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRI 483
K KVTM+AW+++D+ V+TAVN+ LKVWNSYTGQL+H LMGH DEVFVLE HPFD R+
Sbjct: 422 ITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRV 481
Query: 484 MLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIF 543
+ SAGHDG++ +WD+ +G K++ YFNMIEGQGHGAVFDCK S DGQHFACTDSHGHLLIF
Sbjct: 482 LFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIF 541
Query: 544 GFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTK 603
GFG S Y+KI DQMFFH+DYRPLIRD+NN+VLDEQTQQAPHLMPPPFLVDVDGNPHP++
Sbjct: 542 GFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSR 601
Query: 604 YQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQ 663
YQRLVPGREN +E LIPQ+G TS G + Q++S Q N E S LD MI++LQ
Sbjct: 602 YQRLVPGRENCREEQLIPQMG--VTSSG--LNQVLSQQANQ------EISPLDSMIQRLQ 651
Query: 664 QQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNA 723
Q+QD R + G+SN R S ++ SPPN+GLRRSGQ+EGVRQMH NA
Sbjct: 652 QEQDLRRSGE-----AGISNTSRLSRGSISSTS-EVHSPPNVGLRRSGQIEGVRQMHSNA 705
Query: 724 PRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQLSHK 783
PRS+IATERDL AW RRVVVPE+ G+ + E++R KGEEE Y KRK L + K
Sbjct: 706 PRSEIATERDLVAWSRRVVVPELSAGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVP-K 764
Query: 784 SDSVVLVSQS-------------RQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETS 830
+ + VS++ +Q+T + Y + R SSS
Sbjct: 765 ENKIPTVSKNHAHEHFLDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGEV 824
Query: 831 CDQSEGSGSSEEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITR 890
S G+ EE W SD SSSD SS YSDWTADAGINLQPP + +
Sbjct: 825 VAVSGGTSEEEERAWHSD-------GSSSDYSSDYSDWTADAGINLQPPKKVPKNKTKKA 877
Query: 891 FCSSSEDEISTENLSPPKRRRKRK-----------KENKPKKENLRRMTPAELA-NMEHL 938
SS E+E S + ++ K+K K+ KPK+ +R+ EL N L
Sbjct: 878 ESSSDEEEESEKQKQKQIKKEKKKVNEEKDGPISPKKKKPKERKQKRLAVGELTENGLTL 937
Query: 939 YEFHPPVWITDTTLRKSPFVPQMGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMD 998
E+ P WITDT R+ PFVPQMGDEV YFRQGHEAY+E R+N IY +NP K+PW KM+
Sbjct: 938 EEWLPSTWITDTIPRRCPFVPQMGDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKME 997
Query: 999 LRDQELVKIVGIRYEVGPPTLCCLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQF 1058
LR+QEL+KIVGI+YEVG PTLCCLKLAF+DP TGKL SF+++YHDMPDVIDFLVLRQ
Sbjct: 998 LREQELMKIVGIKYEVGLPTLCCLKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQ 1057
Query: 1059 YDEARQRNWQSCDRFRSIIDDAWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSP 1118
+D+A+ R W DRFRS+IDDAWWFGT+ SQEP Q +YPDS FQCY V WDN + EK+SP
Sbjct: 1058 FDDAKYRRWNIGDRFRSVIDDAWWFGTIESQEPLQLEYPDSLFQCYNVCWDNGDTEKMSP 1117
Query: 1119 WDMEPIPDNVDPPEELGASISVTTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLN 1178
WDME IP+N PEELG S+ +T E L+YKP GEWG RDEEC+RI++GI+QL+
Sbjct: 1118 WDMELIPNNAVFPEELGTSVPLTDGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMT 1177
Query: 1179 LDIAAAFAGPVDLCTYPKYCTVVAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNART 1238
LDIA+AF PVDL YP YCTVVAYPTDL TI+ RL NRFYRR+S+L+WEVRYIEHN RT
Sbjct: 1178 LDIASAFVAPVDLQAYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRT 1237
Query: 1239 FNEPESVIARSAKKITDQLLKFIKNQHCTNISELSNTSEND--EQNAEDLDDSDLPKTSS 1296
FNEP S I +SAK +TD LL FIK+Q C NI L N+ + + ++ D+D+P TS+
Sbjct: 1238 FNEPGSPIVKSAKFVTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDSEDEEKDADVPGTST 1297
Query: 1297 GRRRVHDGKKSI--RATNYVESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDII 1354
+R+ H ++ + RA +Y WKKQC+EL+NLIFQCEDSEPFRQPVDL+EYPDYRDII
Sbjct: 1298 RKRKDHQPRRRLRNRAQSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDII 1357
Query: 1355 DTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEK 1414
DTPMDF TVRETL+AGNY+SP+E CKD+RLIFSN+KAYTP+KRS+IYSM+LRLSA FEE
Sbjct: 1358 DTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEH 1417
Query: 1415 MKKISSDFKIGQKFNEKLRRSQRFKQRQ-----NCKGDSQPNKSIRNLKPKRLKSQTKII 1469
+ + SD+K +F+++ ++R K+R + S P + R LKP +LKS++
Sbjct: 1418 ISSVLSDYKSALRFHKRNTITKRRKKRNRSSSVSSSAASSPERKKRILKP-QLKSESS-- 1474
Query: 1470 PELVGSPTQSTSSR------------TAYLGTHKTSAGISSGVTSGDSSDSAESSERRKR 1517
+PT+S R ++ + T + VT S+ SA + K
Sbjct: 1475 TSAFSTPTRSIPPRHNAAQINGKTESSSVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKA 1534
Query: 1518 NRPITNGSTLSESEVEDSLA-TSLSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTR 1576
N G T+ E+ V+ S A +LSS SS ++ A+E+ + +
Sbjct: 1535 NASAIPGKTILENSVKHSKALNTLSSPGQSSFSHGTRNNSAKEN-------------MEK 1581
Query: 1577 TRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEI-LKARAGNNRKVLRK 1631
+ +RK L + + D NN+L G I + G K++++
Sbjct: 1582 EKPVKRKMKSSVLPKASTLSKSSAVIEQGDCKNNALVPGTIQVNGHGGQPSKLVKR 1637
Score = 45.4 bits (106), Expect = 6e-04
Identities = 64/276 (23%), Positives = 112/276 (40%), Gaps = 28/276 (10%)
Query: 1993 ACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDAPSKRKSSSVTSS 2052
A GK +S +K L+ L+ S + + N+ K + P KRK S
Sbjct: 1538 AIPGKTILENSVKHSKALN-TLSSPGQSSFSHGTRNNSAKENMEK-EKPVKRKMKS---- 1591
Query: 2053 GEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKT 2112
S +P + T S S + ++ +NN V + G+ + + P K
Sbjct: 1592 -----SVLPKAST---LSKSSAVIEQGDCKNNALVPGTIQVNGHGGQPSKLVKRGPGRKP 1643
Query: 2113 KVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTD 2172
KV ++ KR R +L+ K + N+ + L S T + + T+
Sbjct: 1644 KVEVNTNSGEIIHKKRGRKPKKLQYAKPEDLEQNNVH----PIRDEVLPSSTCNFLSETN 1699
Query: 2173 NTKTK--RRKTKGKAKVVRKGKTFTAN----ISKTVRRQRQSKRPRLSVDDNDWEDLDYA 2226
N K ++K +G K RK KT + + +V+ R+S R ++ ++ E+ +
Sbjct: 1700 NVKEDLLQKKNRGGRKPKRKMKTQKLDADLLVPASVKVLRRSNRKKIDDPIDEEEEFEEL 1759
Query: 2227 KSKRVLRRSKIKTRNQGRRTVRYHDGDDDRSLENVL 2262
K ++TRNQGRRT Y++ D + +L
Sbjct: 1760 KGSE----PHMRTRNQGRRTAFYNEDDSEEEQRQLL 1791
Score = 32.7 bits (73), Expect = 4.2
Identities = 31/159 (19%), Positives = 69/159 (43%), Gaps = 17/159 (10%)
Query: 2019 DSEDMLNSEHKHR-HTNIHKIDAPSKRKSSSVTSSGEDSKSHIPGS---ETDRTFSSEST 2074
+S+ ++H +R + + + PS+ + +SS E + G E +R + S+ +
Sbjct: 785 ESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGEVVAVSGGTSEEEERAWHSDGS 844
Query: 2075 LAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPE 2134
+ ++ +++ + G L+ K P +KTK S + E+ K+K+ +
Sbjct: 845 SSDYSSDYSDWTADA--------GINLQPPKKVPKNKTKKAESSSDEEEESEKQKQKQIK 896
Query: 2135 LENVKISE-----TTGNSKFRPDTSSKSSDLGSVTESDI 2168
E K++E + K + K +G +TE+ +
Sbjct: 897 KEKKKVNEEKDGPISPKKKKPKERKQKRLAVGELTENGL 935
>gi|55956930 bromodomain and WD repeat domain containing 1 isoform C
[Homo sapiens]
Length = 120
Score = 232 bits (592), Expect = 3e-60
Identities = 116/116 (100%), Positives = 116/116 (100%)
Query: 1 MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN 60
MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN
Sbjct: 1 MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN 60
Query: 61 RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAK 116
RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAK
Sbjct: 61 RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAK 116
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 116 bits (291), Expect = 2e-25
Identities = 88/315 (27%), Positives = 145/315 (46%), Gaps = 34/315 (10%)
Query: 184 GHLSAVYCVAFDRT-GHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTM 242
GH + VY +AF+ G +I TGS D K+WS G+ T RGH+AEI ++ N ++T+
Sbjct: 132 GHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTL 191
Query: 243 IAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQ 302
+A GS D ++W ++ V L+GH+ I SL F+ S +++ D TV W
Sbjct: 192 VATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNT----SGDRIITGSFDHTVVVWD 247
Query: 303 WDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIA 362
D K ++ +SF+ + TGS D +++ + +A
Sbjct: 248 ADTGR--------KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW--DATNGKCVA 297
Query: 363 ELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATR-ISGDLSSEE 421
L H D++ F G + S DGTARI+ ATR L E
Sbjct: 298 TLTGHDDEILDSCFDYTGKLIATASADGTARIF------------SAATRKCIAKLEGHE 345
Query: 422 ERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDS 481
+++ I++N + ++T +D ++W++ TGQ L L GH DE+F + +
Sbjct: 346 -----GEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN-YKG 399
Query: 482 RIMLSAGHDGSIFIW 496
I+++ D + IW
Sbjct: 400 NIVITGSKDNTCRIW 414
Score = 105 bits (263), Expect = 4e-22
Identities = 78/277 (28%), Positives = 118/277 (42%), Gaps = 30/277 (10%)
Query: 177 KMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAV 236
K + GH + + C++F+ + TGS D K+W NG + TLRGHSAEI ++
Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227
Query: 237 NYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADG 296
N I GS D + VW T V +L GH I+S F+ ++ TG+
Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS-----LILTGSMD 282
Query: 297 TVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFE 356
C WD + K + ++L S F G +AT S D R++
Sbjct: 283 KTC-KLWDATNGKCVATLTGHDD------EILDSCFDYTGKLIATASADGTARIF--SAA 333
Query: 357 APEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGD 416
+ IA+LE H ++ I F G+ L+GS D TARIW + + +L I
Sbjct: 334 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFS- 392
Query: 417 LSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVW 453
A+N +IV+T D+ ++W
Sbjct: 393 ---------------CAFNYKGNIVITGSKDNTCRIW 414
Score = 99.4 bits (246), Expect = 4e-20
Identities = 69/214 (32%), Positives = 101/214 (47%), Gaps = 16/214 (7%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMI 243
GH + + ++F+ +G RI TGS D V +W GR ++ L GH AEIS + N++ ++I
Sbjct: 217 GHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLI 276
Query: 244 AAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQW 303
GS DK ++W VA L GH I F K + + ADGT
Sbjct: 277 LTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK----LIATASADGTARI--- 329
Query: 304 DLESLKFSPRPLKFTEKPRPGVQMLCS-SFSVGGMFLATGSTDHVIRMYFLGFEAPEKIA 362
FS K K + SF+ G L TGS+D R++ + + +
Sbjct: 330 ------FSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW--DAQTGQCLQ 381
Query: 363 ELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWR 396
LE HTD++ S F G+ ++GS+D T RIWR
Sbjct: 382 VLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 84.7 bits (208), Expect = 9e-16
Identities = 69/317 (21%), Positives = 137/317 (43%), Gaps = 35/317 (11%)
Query: 214 STHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSI 273
S H L L+ H ++++A+N + GS D+ ++W + + L+GH +
Sbjct: 78 SNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVV 137
Query: 274 TSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFS 333
++ F+ ++TG+ C W +E+ K T +++C SF+
Sbjct: 138 YAIAFN----NPYGDKIATGSFDKTC-KLWSVETGKCYHTFRGHT------AEIVCLSFN 186
Query: 334 VGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTAR 393
+ATGS D +++ + E++ L H+ ++ S+ F +GDR ++GS D T
Sbjct: 187 PQSTLVATGSMDTTAKLW--DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVV 244
Query: 394 IWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVW 453
+W + +IL+ IS ++N + S+++T D K+W
Sbjct: 245 VWDADTGRKVNILIGHCAEISS----------------ASFNWDCSLILTGSMDKTCKLW 288
Query: 454 NSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEG 513
++ G+ + L GH DE+ + + +++ +A DG+ I+ + +EG
Sbjct: 289 DATNGKCVATLTGHDDEI-LDSCFDYTGKLIATASADGTARIF----SAATRKCIAKLEG 343
Query: 514 QGHGAVFDCKFSQDGQH 530
G + F+ G H
Sbjct: 344 H-EGEISKISFNPQGNH 359
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 103 bits (258), Expect = 1e-21
Identities = 113/487 (23%), Positives = 207/487 (42%), Gaps = 67/487 (13%)
Query: 54 WEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAG---RQS 110
W G E + +EL+ S + H++Q+ I P ++ + + +L +
Sbjct: 126 WSGPEKLLALDELIDSCEPTQVKHMMQV---IEPQFQRDFISLLPKELALYVLSFLEPKD 182
Query: 111 LLRTAKDCRHTVWKGSAFA-ALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFP 169
LL+ A+ CR+ W+ A L R + E ++ + I R K + S
Sbjct: 183 LLQAAQTCRY--WRILAEDNLLWREKCKEEGID-----EPLHIKRRKVIKPGFIHSPWKS 235
Query: 170 GTMYQH----------IKMHRRILGHLSAVY-CVAFDRTGHRIFTGSDDCLVKIWSTHNG 218
+ QH +K + + GH V C+ F G+RI +GSDD +K+WS G
Sbjct: 236 AYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTG 293
Query: 219 RLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQF 278
+ L TL GH+ + + + +I +GS D+ ++VW T + L GHT ++ +
Sbjct: 294 KCLRTLVGHTGGV--WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 351
Query: 279 SPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMF 338
++ +VS D T+ W D+E+ + + R C + G
Sbjct: 352 H------EKRVVSGSRDATLRVW--DIETGQCLHVLMGHVAAVR------CVQYD--GRR 395
Query: 339 LATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFE 398
+ +G+ D +++++ E + L+ HT++V S+QF +G +SGS D + R+W E
Sbjct: 396 VVSGAYDFMVKVW--DPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVE 451
Query: 399 QLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTG 458
L + SG D+I+V+ D +K+W+ TG
Sbjct: 452 TGNCIHTLTGHQSLTSG------------------MELKDNILVSGNADSTVKIWDIKTG 493
Query: 459 QLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGA 518
Q L L G + F+ ++++ DG++ +WD+ G +++ + G G
Sbjct: 494 QCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 553
Query: 519 VFDCKFS 525
V+ + S
Sbjct: 554 VWRIRAS 560
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 103 bits (258), Expect = 1e-21
Identities = 113/487 (23%), Positives = 207/487 (42%), Gaps = 67/487 (13%)
Query: 54 WEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAG---RQS 110
W G E + +EL+ S + H++Q+ I P ++ + + +L +
Sbjct: 244 WSGPEKLLALDELIDSCEPTQVKHMMQV---IEPQFQRDFISLLPKELALYVLSFLEPKD 300
Query: 111 LLRTAKDCRHTVWKGSAFA-ALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFP 169
LL+ A+ CR+ W+ A L R + E ++ + I R K + S
Sbjct: 301 LLQAAQTCRY--WRILAEDNLLWREKCKEEGID-----EPLHIKRRKVIKPGFIHSPWKS 353
Query: 170 GTMYQH----------IKMHRRILGHLSAVY-CVAFDRTGHRIFTGSDDCLVKIWSTHNG 218
+ QH +K + + GH V C+ F G+RI +GSDD +K+WS G
Sbjct: 354 AYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTG 411
Query: 219 RLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQF 278
+ L TL GH+ + + + +I +GS D+ ++VW T + L GHT ++ +
Sbjct: 412 KCLRTLVGHTGGV--WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 469
Query: 279 SPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMF 338
++ +VS D T+ W D+E+ + + R C + G
Sbjct: 470 H------EKRVVSGSRDATLRVW--DIETGQCLHVLMGHVAAVR------CVQYD--GRR 513
Query: 339 LATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFE 398
+ +G+ D +++++ E + L+ HT++V S+QF +G +SGS D + R+W E
Sbjct: 514 VVSGAYDFMVKVW--DPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVE 569
Query: 399 QLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTG 458
L + SG D+I+V+ D +K+W+ TG
Sbjct: 570 TGNCIHTLTGHQSLTSG------------------MELKDNILVSGNADSTVKIWDIKTG 611
Query: 459 QLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGA 518
Q L L G + F+ ++++ DG++ +WD+ G +++ + G G
Sbjct: 612 QCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 671
Query: 519 VFDCKFS 525
V+ + S
Sbjct: 672 VWRIRAS 678
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 103 bits (258), Expect = 1e-21
Identities = 113/487 (23%), Positives = 207/487 (42%), Gaps = 67/487 (13%)
Query: 54 WEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAG---RQS 110
W G E + +EL+ S + H++Q+ I P ++ + + +L +
Sbjct: 164 WSGPEKLLALDELIDSCEPTQVKHMMQV---IEPQFQRDFISLLPKELALYVLSFLEPKD 220
Query: 111 LLRTAKDCRHTVWKGSAFA-ALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFP 169
LL+ A+ CR+ W+ A L R + E ++ + I R K + S
Sbjct: 221 LLQAAQTCRY--WRILAEDNLLWREKCKEEGID-----EPLHIKRRKVIKPGFIHSPWKS 273
Query: 170 GTMYQH----------IKMHRRILGHLSAVY-CVAFDRTGHRIFTGSDDCLVKIWSTHNG 218
+ QH +K + + GH V C+ F G+RI +GSDD +K+WS G
Sbjct: 274 AYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTG 331
Query: 219 RLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQF 278
+ L TL GH+ + + + +I +GS D+ ++VW T + L GHT ++ +
Sbjct: 332 KCLRTLVGHTGGV--WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 389
Query: 279 SPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMF 338
++ +VS D T+ W D+E+ + + R C + G
Sbjct: 390 H------EKRVVSGSRDATLRVW--DIETGQCLHVLMGHVAAVR------CVQYD--GRR 433
Query: 339 LATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFE 398
+ +G+ D +++++ E + L+ HT++V S+QF +G +SGS D + R+W E
Sbjct: 434 VVSGAYDFMVKVW--DPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVE 489
Query: 399 QLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTG 458
L + SG D+I+V+ D +K+W+ TG
Sbjct: 490 TGNCIHTLTGHQSLTSG------------------MELKDNILVSGNADSTVKIWDIKTG 531
Query: 459 QLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGA 518
Q L L G + F+ ++++ DG++ +WD+ G +++ + G G
Sbjct: 532 QCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 591
Query: 519 VFDCKFS 525
V+ + S
Sbjct: 592 VWRIRAS 598
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 103 bits (258), Expect = 1e-21
Identities = 80/317 (25%), Positives = 148/317 (46%), Gaps = 26/317 (8%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNG-RLLSTLRGHSAEISDMAVNYENTM 242
GH VYC F G + + D L+ +W+ + +TL+GHS + ++ N + +M
Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
Query: 243 IAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGA-DGTVCFW 301
+ + S DK + VW T V L+GHT + S P +G Q +V TG+ DGTV
Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCY--PARRGPQ--LVCTGSDDGTVKL- 178
Query: 302 QWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKI 361
WD+ K + + + T Q+L +F+ + +G D+ I+++ L +
Sbjct: 179 -WDIRK-KAAIQTFQNT------YQVLAVTFNDTSDQIISGGIDNDIKVWDL--RQNKLT 228
Query: 362 AELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEE 421
+ H D V + + G LS + D T R+W + + + G++ + E
Sbjct: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKI---FQGNVHNFE 285
Query: 422 ERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDS 481
+ ++ +W+ + S + D + VW++ + ++L+ L GHA + + HP D
Sbjct: 286 KNLLR-----CSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP-DE 339
Query: 482 RIMLSAGHDGSIFIWDI 498
I++SA D +++ +I
Sbjct: 340 PIIISASSDKRLYMGEI 356
Score = 75.9 bits (185), Expect = 4e-13
Identities = 71/328 (21%), Positives = 134/328 (40%), Gaps = 41/328 (12%)
Query: 256 CLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPL 315
C AP+ +L GH G + +F P GS + S G D + W + ++
Sbjct: 52 CSSLQAPIMLLSGHEGEVYCCKFHP--NGST--LASAGFDRLILLWNVYGDCDNYA---- 103
Query: 316 KFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQ 375
T K G M ++ G L + STD + ++ E E++ L+ HT V+S
Sbjct: 104 --TLKGHSGAVMEL-HYNTDGSMLFSASTDKTVAVW--DSETGERVKRLKGHTSFVNSCY 158
Query: 376 FCNNGDRFL-SGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAW 434
G + + +GS DGT ++W R + + + + +V + +
Sbjct: 159 PARRGPQLVCTGSDDGTVKLWDI--------------RKKAAIQTFQNTY---QVLAVTF 201
Query: 435 NQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIF 494
N +++ D+ +KVW+ +L + + GHAD V L + +LS D ++
Sbjct: 202 NDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSS-EGSYLLSNAMDNTVR 260
Query: 495 IWDITKGTKMKHYFNMIEGQGHG---AVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPY 551
+WD+ + + +G H + C +S DG A + + ++ +
Sbjct: 261 VWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL 320
Query: 552 EKIP------DQMFFHTDYRPLIRDSNN 573
K+P +++ FH D +I S++
Sbjct: 321 YKLPGHAGSINEVAFHPDEPIIISASSD 348
Score = 58.5 bits (140), Expect = 7e-08
Identities = 58/262 (22%), Positives = 102/262 (38%), Gaps = 52/262 (19%)
Query: 172 MYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEI 231
+Y + + GH AV + ++ G +F+ S D V +W + G + L+GH++ +
Sbjct: 95 VYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFV 154
Query: 232 SD----------------------------------------MAVNYENT--MIAAGSCD 249
+ +AV + +T I +G D
Sbjct: 155 NSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGID 214
Query: 250 KIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLK 309
I+VW LR ++GH S+T L S ++GS Y++S D TV WD+
Sbjct: 215 NDIKVWDLRQNKLTYTMRGHADSVTGLSLS--SEGS--YLLSNAMDNTVRV--WDVRPFA 268
Query: 310 FSPRPLKFTEKPRPGVQ--MLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESH 367
R +K + + +L S+S G +A GS D + Y + + +L H
Sbjct: 269 PKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFV--YVWDTTSRRILYKLPGH 326
Query: 368 TDKVDSIQFCNNGDRFLSGSRD 389
++ + F + +S S D
Sbjct: 327 AGSINEVAFHPDEPIIISASSD 348
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 103 bits (258), Expect = 1e-21
Identities = 81/316 (25%), Positives = 142/316 (44%), Gaps = 27/316 (8%)
Query: 182 ILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENT 241
++GH AV V F G + + S D L+ IW ++G+ TL GH+ EISD+A + +++
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 242 MIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFW 301
+ + S DK +++W +R+ + L+GH+ + F+P ++S D TV W
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP----PSNLIISGSFDETVKIW 152
Query: 302 QWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKI 361
+ + L P V CS G + +GS D + R++ K
Sbjct: 153 EVKTGKCL---KTLSAHSDPVSAVHFNCS-----GSLIVSGSYDGLCRIWDAASGQCLKT 204
Query: 362 AELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEE 421
++ V ++F NG L+ + D T ++W + R L T G + +
Sbjct: 205 L-VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYS----RGRCLKTYT---GHKNEKY 256
Query: 422 ERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDS 481
F VT W +V+ D+++ +WN T +++ L GH D V HP ++
Sbjct: 257 CIFANFSVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN 310
Query: 482 RIMLSA-GHDGSIFIW 496
I +A +D +I +W
Sbjct: 311 LIASAALENDKTIKLW 326
Score = 81.3 bits (199), Expect = 1e-14
Identities = 66/284 (23%), Positives = 124/284 (43%), Gaps = 31/284 (10%)
Query: 217 NGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSL 276
N L TL GH+ +S + + +A+ S D++I +W L GH I+ +
Sbjct: 30 NYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDV 89
Query: 277 QFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGG 336
+S +VS D T+ WD+ S K + LK + C +F+
Sbjct: 90 AWS----SDSSRLVSASDDKTLKL--WDVRSGK-CLKTLKGHSN-----YVFCCNFNPPS 137
Query: 337 MFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWR 396
+ +GS D ++++ + + + + L +H+D V ++ F +G +SGS DG RIW
Sbjct: 138 NLIISGSFDETVKIWEV--KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Query: 397 FEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSY 456
+ L+D P V+ + ++ N ++TA D+ LK+W+
Sbjct: 196 AASGQCLKTLVDDD---------------NPPVSFVKFSPNGKYILTATLDNTLKLWDYS 240
Query: 457 TGQLLHNLMGHADEVFVLETH--PFDSRIMLSAGHDGSIFIWDI 498
G+ L GH +E + + + + ++S D ++IW++
Sbjct: 241 RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 284
Score = 75.1 bits (183), Expect = 7e-13
Identities = 62/260 (23%), Positives = 114/260 (43%), Gaps = 48/260 (18%)
Query: 177 KMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAV 236
K + + GH + VA+ R+ + SDD +K+W +G+ L TL+GHS +
Sbjct: 74 KYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNF 133
Query: 237 NYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADG 296
N + +I +GS D+ +++W ++T + L H+ ++++ F+ GS +VS DG
Sbjct: 134 NPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFN--CSGS--LIVSGSYDG 189
Query: 297 TVCFWQW---------------DLESLKFSP----------------------RPLKFTE 319
W + +KFSP R LK
Sbjct: 190 LCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT 249
Query: 320 KPRPGVQMLCSSFSV-GGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCN 378
+ + ++FSV GG ++ +GS D+++ Y + E + +L+ HTD V S C+
Sbjct: 250 GHKNEKYCIFANFSVTGGKWIVSGSEDNLV--YIWNLQTKEIVQKLQGHTDVVISAA-CH 306
Query: 379 NGDRFLSGS---RDGTARIW 395
+ ++ + D T ++W
Sbjct: 307 PTENLIASAALENDKTIKLW 326
Score = 52.8 bits (125), Expect = 4e-06
Identities = 52/232 (22%), Positives = 85/232 (36%), Gaps = 64/232 (27%)
Query: 364 LESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEER 423
L HT+ V S++F NG+ S S D IW ++ L IS
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISD-------- 88
Query: 424 FMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHP----- 478
+AW+ + S +V+A +D LK+W+ +G+ L L GH++ VF +P
Sbjct: 89 --------VAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLI 140
Query: 479 ----FDSRI--------------------------------MLSAGHDGSIFIWDITKGT 502
FD + ++S +DG IWD G
Sbjct: 141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ 200
Query: 503 KMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFG---CSKPY 551
+K +++ F KFS +G++ L ++ + C K Y
Sbjct: 201 CLK---TLVDDDNPPVSF-VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY 248
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 98.6 bits (244), Expect = 6e-20
Identities = 80/341 (23%), Positives = 153/341 (44%), Gaps = 27/341 (7%)
Query: 157 QLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTH 216
Q T S+ + + P + + + + GH AV V F G + + S D L+KIW +
Sbjct: 16 QPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY 75
Query: 217 NGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSL 276
+G+ T+ GH ISD+A + ++ ++ + S DK +++W + + + L+GH+ +
Sbjct: 76 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135
Query: 277 QFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGG 336
F+P + +VS D +V WD+++ K + L P V F+ G
Sbjct: 136 NFNPQS----NLIVSGSFDESVRI--WDVKTGK-CLKTLPAHSDPVSAVH-----FNRDG 183
Query: 337 MFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWR 396
+ + S D + R++ K ++ V ++F NG L+ + D T ++W
Sbjct: 184 SLIVSSSYDGLCRIWDTASGQCLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
Query: 397 FEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSY 456
+ + + +G + + F VT W +V+ D+++ +WN
Sbjct: 243 YSKGK-------CLKTYTGHKNEKYCIFANFSVTGGKW------IVSGSEDNLVYIWNLQ 289
Query: 457 TGQLLHNLMGHADEVFVLETHPFDSRIMLSA-GHDGSIFIW 496
T +++ L GH D V HP ++ I +A +D +I +W
Sbjct: 290 TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 56.6 bits (135), Expect = 3e-07
Identities = 54/237 (22%), Positives = 91/237 (38%), Gaps = 74/237 (31%)
Query: 364 LESHTDKVDSIQFCNNGDRFLSGSRDGTARIW-----RFEQLEWRSILLDMATRISGDLS 418
L HT V S++F NG+ S S D +IW +FE+ ISG
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT------------ISGH-- 86
Query: 419 SEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHP 478
K ++ +AW+ + +++V+A +D LK+W+ +G+ L L GH++ VF +P
Sbjct: 87 -------KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139
Query: 479 F-----------------------------------------DSRIMLSAGHDGSIFIWD 497
D +++S+ +DG IWD
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Query: 498 ITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFG---CSKPY 551
G +K +I+ F KFS +G++ L ++ + C K Y
Sbjct: 200 TASGQCLK---TLIDDDNPPVSF-VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 98.6 bits (244), Expect = 6e-20
Identities = 80/341 (23%), Positives = 153/341 (44%), Gaps = 27/341 (7%)
Query: 157 QLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTH 216
Q T S+ + + P + + + + GH AV V F G + + S D L+KIW +
Sbjct: 16 QPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY 75
Query: 217 NGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSL 276
+G+ T+ GH ISD+A + ++ ++ + S DK +++W + + + L+GH+ +
Sbjct: 76 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135
Query: 277 QFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGG 336
F+P + +VS D +V WD+++ K + L P V F+ G
Sbjct: 136 NFNPQS----NLIVSGSFDESVRI--WDVKTGK-CLKTLPAHSDPVSAVH-----FNRDG 183
Query: 337 MFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWR 396
+ + S D + R++ K ++ V ++F NG L+ + D T ++W
Sbjct: 184 SLIVSSSYDGLCRIWDTASGQCLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
Query: 397 FEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSY 456
+ + + +G + + F VT W +V+ D+++ +WN
Sbjct: 243 YSKGK-------CLKTYTGHKNEKYCIFANFSVTGGKW------IVSGSEDNLVYIWNLQ 289
Query: 457 TGQLLHNLMGHADEVFVLETHPFDSRIMLSA-GHDGSIFIW 496
T +++ L GH D V HP ++ I +A +D +I +W
Sbjct: 290 TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 56.6 bits (135), Expect = 3e-07
Identities = 54/237 (22%), Positives = 91/237 (38%), Gaps = 74/237 (31%)
Query: 364 LESHTDKVDSIQFCNNGDRFLSGSRDGTARIW-----RFEQLEWRSILLDMATRISGDLS 418
L HT V S++F NG+ S S D +IW +FE+ ISG
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT------------ISGH-- 86
Query: 419 SEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHP 478
K ++ +AW+ + +++V+A +D LK+W+ +G+ L L GH++ VF +P
Sbjct: 87 -------KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139
Query: 479 F-----------------------------------------DSRIMLSAGHDGSIFIWD 497
D +++S+ +DG IWD
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Query: 498 ITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFG---CSKPY 551
G +K +I+ F KFS +G++ L ++ + C K Y
Sbjct: 200 TASGQCLK---TLIDDDNPPVSF-VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 98.2 bits (243), Expect = 8e-20
Identities = 63/223 (28%), Positives = 101/223 (45%), Gaps = 15/223 (6%)
Query: 180 RRILGHLSAVYCVAFDRTGHRIF-TGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNY 238
+ I+ H S V + + R+ TG DDC V +WS + + +L GH++ + + +N
Sbjct: 14 QEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNT 73
Query: 239 ENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTV 298
+I AGS IRVW L + L GH +I SL F P + ++ S D +
Sbjct: 74 PEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGE----FVASGSQDTNI 129
Query: 299 CFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAP 358
W + F R + C FS G +LA+ + DH ++++ L A
Sbjct: 130 KLWDIRRKGCVFRYR--------GHSQAVRCLRFSPDGKWLASAADDHTVKLWDL--TAG 179
Query: 359 EKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE 401
+ ++E HT V+ ++F N SGS D T R W E+ +
Sbjct: 180 KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQ 222
Score = 71.2 bits (173), Expect = 1e-11
Identities = 70/292 (23%), Positives = 129/292 (44%), Gaps = 25/292 (8%)
Query: 91 KEIPPSISRVTSL-LGAGRQSLLRTA-KDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPN 148
+EI S V+SL LG LL T DCR +W ++++ + SP
Sbjct: 14 QEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLW------SINKPNCIMSLTGHTSPVE 67
Query: 149 LVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDC 208
V ++ ++L + S + + K+ R ++GH + + + F G + +GS D
Sbjct: 68 SVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
Query: 209 LVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQG 268
+K+W + RGHS + + + + +A+ + D +++W L ++ G
Sbjct: 128 NIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG 187
Query: 269 HTGSITSLQFSPMAKGSQRYMVSTG-ADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQM 327
HTG + ++F P Y++++G +D T+ F WDLE + +P P +
Sbjct: 188 HTGPVNVVEFHP-----NEYLLASGSSDRTIRF--WDLEKFQVVS---CIEGEPGPVRSV 237
Query: 328 LCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNN 379
L F+ G L +G D +R+Y G+E + + KV + CN+
Sbjct: 238 L---FNPDGCCLYSGCQDS-LRVY--GWEPERCFDVVLVNWGKVADLAICND 283
Score = 63.5 bits (153), Expect = 2e-09
Identities = 58/238 (24%), Positives = 101/238 (42%), Gaps = 39/238 (16%)
Query: 336 GMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW 395
G LATG D + ++ + P I L HT V+S++ + ++GS+ G+ R+W
Sbjct: 33 GRLLATGGDDCRVNLWSIN--KPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVW 90
Query: 396 RFEQLE-WRSILLDMATRISGDLSSEEE-------------------------RFMKPKV 429
E + R+++ A S D E R V
Sbjct: 91 DLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAV 150
Query: 430 TMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGH 489
+ ++ + + +A +DH +K+W+ G+++ GH V V+E HP + ++ S
Sbjct: 151 RCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHP-NEYLLASGSS 209
Query: 490 DGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDG--QHFACTDSHGHLLIFGF 545
D +I WD+ K + IEG+ G V F+ DG + C DS L ++G+
Sbjct: 210 DRTIRFWDLEK----FQVVSCIEGE-PGPVRSVLFNPDGCCLYSGCQDS---LRVYGW 259
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 98.2 bits (243), Expect = 8e-20
Identities = 85/307 (27%), Positives = 137/307 (44%), Gaps = 31/307 (10%)
Query: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
H V AF G + TGS+D V W T +G+LL L GH+ + + + + A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 245 AGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWD 304
+ SCD +R+W + + VL+GH S+ ++ FSP R + S G D V WD
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSP----DSRQLASGGWDKRVML--WD 133
Query: 305 LESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAE- 363
++ S + L+ R +Q S FS LATGS D + ++ L P +
Sbjct: 134 VQ----SGQMLRLLVGHRDSIQ--SSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
Query: 364 LESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEER 423
LE H+ + + + +G SGS D T IW+ S+L+ + ++
Sbjct: 188 LEGHSANISCLCYSASG-LLASGSWDKTIHIWK---PTTSSLLIQLKGHVTW-------- 235
Query: 424 FMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRI 483
V IA++ ++ + +A ++KVW+ TG+ L L G D P D +I
Sbjct: 236 -----VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTP-DGKI 289
Query: 484 MLSAGHD 490
++S D
Sbjct: 290 LVSGAAD 296
Score = 75.9 bits (185), Expect = 4e-13
Identities = 57/216 (26%), Positives = 96/216 (44%), Gaps = 14/216 (6%)
Query: 181 RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN 240
R+ GH V F GH + S DC V++W + L L+GH + ++ + ++
Sbjct: 58 RLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDS 117
Query: 241 TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGA-DGTVC 299
+A+G DK + +W +++ + +L GH SI S FSP ++TG+ D TV
Sbjct: 118 RQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVN-----CLATGSWDSTVH 172
Query: 300 FWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPE 359
W + + S + L E + LC +S G+ LA+GS D I ++
Sbjct: 173 IWDLRMVTPAVSHQAL---EGHSANISCLC--YSASGL-LASGSWDKTIHIW--KPTTSS 224
Query: 360 KIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW 395
+ +L+ H V SI F + S ++W
Sbjct: 225 LLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
Score = 59.3 bits (142), Expect = 4e-08
Identities = 51/221 (23%), Positives = 91/221 (41%), Gaps = 20/221 (9%)
Query: 177 KMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAV 236
K R + GH +V V+F ++ +G D V +W +G++L L GH I
Sbjct: 96 KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDF 155
Query: 237 NYENTMIAAGSCDKIIRVWCLRTCAPVA---VLQGHTGSITSLQFSPMAKGSQRYMVSTG 293
+ +A GS D + +W LR P L+GH+ +I+ L +S
Sbjct: 156 SPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYS-------------- 201
Query: 294 ADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCS-SFSVGGMFLATGSTDHVIRMYF 352
A G + WD + P + + V + S +FS ++LA+ +++++
Sbjct: 202 ASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW- 260
Query: 353 LGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTAR 393
+ + L+ D + F +G +SG+ D T R
Sbjct: 261 -DCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 46.6 bits (109), Expect = 3e-04
Identities = 37/151 (24%), Positives = 61/151 (40%), Gaps = 21/151 (13%)
Query: 357 APEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW--RFEQLEWRSILLDMATRIS 414
A ++ H +V+S F +G L+GS DG W R QL WR +
Sbjct: 10 AVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR---------LG 60
Query: 415 GDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVL 474
G V ++ + + +A D +++W+ + L L GH V +
Sbjct: 61 GHTGP---------VKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV 111
Query: 475 ETHPFDSRIMLSAGHDGSIFIWDITKGTKMK 505
P DSR + S G D + +WD+ G ++
Sbjct: 112 SFSP-DSRQLASGGWDKRVMLWDVQSGQMLR 141
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 94.0 bits (232), Expect = 2e-18
Identities = 61/224 (27%), Positives = 102/224 (45%), Gaps = 18/224 (8%)
Query: 182 ILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENT 241
+ GH VY +F + + + S+D V++WS L +GH+ + D +
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
Query: 242 MIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFW 301
+G D++ R+W P+ + GH + +F P + Y+ + AD TV W
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP----NSNYVATGSADRTVRLW 654
Query: 302 QWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKI 361
+ ++ + + L +FS G FLATG+TD + ++ +G +
Sbjct: 655 D------VLNGNCVRIFTGHKGPIHSL--TFSPNGRFLATGATDGRVLLWDIGHGL--MV 704
Query: 362 AELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW----RFEQLE 401
EL+ HTD V S++F +G+ SGS D T R+W FE LE
Sbjct: 705 GELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLE 748
Score = 73.9 bits (180), Expect = 2e-12
Identities = 75/317 (23%), Positives = 123/317 (38%), Gaps = 50/317 (15%)
Query: 204 GSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPV 263
G D V++WS +L S + SD++ +I S D + R+ +T + +
Sbjct: 488 GFADSTVRVWSVTPKKLRSV-----KQASDLS------LIDKESDDVLERIMDEKTASEL 536
Query: 264 AVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWD----LESLKFSPRPLKFTE 319
+L GH+G + FSP + Y++S+ DGTV W L K P+ T+
Sbjct: 537 KILYGHSGPVYGASFSP----DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQ 592
Query: 320 KPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNN 379
FS G + +G D V R++ P +I H V+ +F N
Sbjct: 593 ------------FSPYGYYFVSGGHDRVARLWATDHYQPLRI--FAGHLADVNCTRFHPN 638
Query: 380 GDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDS 439
+ +GS D T R+W +L RI K + + ++ N
Sbjct: 639 SNYVATGSADRTVRLW--------DVLNGNCVRIFTG--------HKGPIHSLTFSPNGR 682
Query: 440 IVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDIT 499
+ T D + +W+ G ++ L GH D V L D I+ S D ++ +WD
Sbjct: 683 FLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLR-FSRDGEILASGSMDNTVRLWDAI 741
Query: 500 KGTKMKHYFNMIEGQGH 516
K + + GH
Sbjct: 742 KAFEDLETDDFTTATGH 758
Score = 70.5 bits (171), Expect = 2e-11
Identities = 53/205 (25%), Positives = 90/205 (43%), Gaps = 16/205 (7%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMI 243
GH V+ F G+ +G D + ++W+T + + L GH A+++ + + +
Sbjct: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV 642
Query: 244 AAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQW 303
A GS D+ +R+W + V + GH G I SL FSP + R++ + DG V W
Sbjct: 643 ATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSP----NGRFLATGATDGRVLLWDI 698
Query: 304 DLESLKFSPRPLKFTEKPRPGVQMLCS-SFSVGGMFLATGSTDHVIRMYFLGFEAPEKIA 362
+ + + +CS FS G LA+GS D+ +R++ +A E +
Sbjct: 699 GHGLM---------VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD-AIKAFEDL- 747
Query: 363 ELESHTDKVDSIQFCNNGDRFLSGS 387
E + T I N L G+
Sbjct: 748 ETDDFTTATGHINLPENSQELLLGT 772
Score = 64.7 bits (156), Expect = 1e-09
Identities = 37/127 (29%), Positives = 56/127 (44%), Gaps = 4/127 (3%)
Query: 175 HIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDM 234
H + R GHL+ V C F + + TGS D V++W NG + GH I +
Sbjct: 616 HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL 675
Query: 235 AVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGA 294
+ +A G+ D + +W + V L+GHT ++ SL+FS + S
Sbjct: 676 TFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS----RDGEILASGSM 731
Query: 295 DGTVCFW 301
D TV W
Sbjct: 732 DNTVRLW 738
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 93.2 bits (230), Expect = 3e-18
Identities = 135/715 (18%), Positives = 255/715 (35%), Gaps = 25/715 (3%)
Query: 1475 SPTQSTSSRTAYLGTHKTSAGISSGVTSGDSSDSAESSERRKRNRPITNGSTLSESEVED 1534
S + S+ S + S+ S S DSSDS++SS+ + + + S+ S+S+ +
Sbjct: 583 SDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDS 642
Query: 1535 SLATSLSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCG 1594
S + S SS +S S +S SS + +SS S S SS+ ++ S +
Sbjct: 643 SDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSS-------SSDSSNSSDSSDSSDS 695
Query: 1595 RKATRKRVYLSDSDNNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSES 1654
++ SD++S ++ + + + ++ ++N + SS+S
Sbjct: 696 SNSSESSDSSDSSDSDSSDSSDSSNSNSSDSD---------SSNSSDSSDSSNSSDSSDS 746
Query: 1655 VCSGRKLPHRNASAVARKKLLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDE 1714
S ++S + +S D + D + S S + + +
Sbjct: 747 SDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNS 806
Query: 1715 SENRDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSE-EDSKSHDSDHACNRTA 1773
S++ DS SD + + +N S + S +SS+ DS S + + N +
Sbjct: 807 SDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSD 866
Query: 1774 GPSTSVQKLKAESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDS-----ESE 1828
+S ++S S+ +DS + ++ + + S + SDS DS SE
Sbjct: 867 SSDSSDSSNSSDS-SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSE 925
Query: 1829 EQDREDGKCHKMEMNPISGNLNCDPIAMSQCSSDHGCETDLDSDDDKIEKPNNFMKDSAS 1888
+ D N + + D S S+ DS D ++ S S
Sbjct: 926 SSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDS 985
Query: 1889 QDNGLSRKISRKRVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDV 1948
D+ S S S+ SDSS S + + ++ ++ SD D
Sbjct: 986 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDS 1045
Query: 1949 SLENVHTRSKNGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTK 2008
S + + S N + + + S E + S+ S
Sbjct: 1046 SDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDS 1105
Query: 2009 VLSQALNGDSDSEDMLNSEHKHRHTNIHKIDAPSKRKSSSVTSSGEDSKSHIPGSETDRT 2068
S + SDS D NS ++ D+ SS + S E S S +D +
Sbjct: 1106 SDSSDSSDSSDSSDSSNSSDSSDSSD--SSDSSDSSNSSDSSDSSESSDSSDSSDSSDSS 1163
Query: 2069 FSSESTLAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKR 2128
SS+S+ + ++ +N + + + + S + DS ++++
Sbjct: 1164 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1223
Query: 2129 KRSHPELENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTDNTKTKRRKTKG 2183
S N + + SS SSD ++S D D + ++ + G
Sbjct: 1224 DSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNG 1278
Score = 90.1 bits (222), Expect = 2e-17
Identities = 128/603 (21%), Positives = 226/603 (37%), Gaps = 43/603 (7%)
Query: 1475 SPTQSTSSRTAYLGTHKTSAGISSGVTSGDSSDSAESSERRKRNRPITNGSTLSESEVED 1534
S S SS ++ S+ S S DSSDS++SS+ + + + + S+ D
Sbjct: 737 SSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSD 796
Query: 1535 SLATSLSSSASSSSEES----KESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLA 1590
S +S SS++S SS+ S +SS + +SS+ S S SSN + + +
Sbjct: 797 SSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSS 856
Query: 1591 NGCGRKATRKRVYLSDSDNNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEENS 1650
N + SDS N+S + + N+ SD +S
Sbjct: 857 NRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD---------------SSDSSNSS 901
Query: 1651 SSESVCSGRKLPHRNASAVARKKLLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQS 1710
S+S S ++S + NS D + + D + SS+ + S
Sbjct: 902 DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSD----SSNSSDSS 957
Query: 1711 NVDESENRDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHACN 1770
N +S N S+S+ + + +++ + + + +S + S S DS + N
Sbjct: 958 NSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSN 1017
Query: 1771 RTAGPSTSVQKLKAESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDSESEEQ 1830
+ ++S ++S S+ S ++ N+S + SDS DS S+
Sbjct: 1018 SSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS-SDSS 1076
Query: 1831 DREDGKCHKMEMNPISGNLNCDPIAMSQCSSDHGCETDLDSDDDKIEKPNNFMKDSASQD 1890
D D E + S + N + S SSD +D D + N+ S S D
Sbjct: 1077 DSSDSS----ESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNS----SDSSD 1128
Query: 1891 NGLSRKISRKRVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDVSL 1950
+ S S S SDSS S + + ++ ++ SD D S
Sbjct: 1129 SSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1188
Query: 1951 ENVHTRSKNGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTKVL 2010
+ + S + ++ SD S S+ DS S+
Sbjct: 1189 SSDSSDSSD----------SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSS 1238
Query: 2011 SQALNGDS-DSEDMLNSEHKHRHTNIHKIDAPSKRKSSSVTSSGEDSKSHIPGSETDRTF 2069
+ + DS +S D +S T+ ++ S+ KS + ++G DS S GS+++ +
Sbjct: 1239 DSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHST 1298
Query: 2070 SSE 2072
S +
Sbjct: 1299 SDD 1301
Score = 74.7 bits (182), Expect = 1e-12
Identities = 149/759 (19%), Positives = 265/759 (34%), Gaps = 95/759 (12%)
Query: 1426 QKFNEKLRRSQRFKQRQNCKGDSQP--NKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSR 1483
QK N R S+R + R + ++ + ++ K S + I + VG + +
Sbjct: 345 QKLNH--RESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDK 402
Query: 1484 TAYLGTHKTSAGISSGVTSGDSSDSAESSERRKRNRPITNGSTLSESEVE-----DSLAT 1538
G H G + T G+ + ++ + + + +T S+S + D
Sbjct: 403 ----GQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDK 458
Query: 1539 SLSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKAT 1598
S+ +SS+ES + A S + SR A+ NG K
Sbjct: 459 SMQGDDPNSSDESNGNDDANSESDNNSSSRGD--------ASYNSDESKDNGNGSDSKGA 510
Query: 1599 RKRVYLSDSD-NNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCS 1657
S SD NNS G N++ ++ K SD ++ SS+S
Sbjct: 511 EDDDSDSTSDTNNSDSNGNGNNGNDDNDK----------SDSGKGKSDSSDSDSSDS--- 557
Query: 1658 GRKLPHRNASAVARKKLLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESEN 1717
NS D S+ + + D N SS + S+ +S++
Sbjct: 558 ------------------SNSSDS----SDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDS 595
Query: 1718 RDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPST 1777
DS + SD + + ++ + + S + + +SS+ DSKS SD + ++ S
Sbjct: 596 SDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSD 655
Query: 1778 SVQKLKAESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDS--ESEEQDREDG 1835
S + + S+ +DS ++ + + S SDS DS SE D D
Sbjct: 656 SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDS--------SDSSDSSNSSESSDSSDS 707
Query: 1836 KCHKMEMNPISGNLNCDPIAMSQCSSDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSR 1895
+ S N N S S DS D ++ DS+ N
Sbjct: 708 SDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDS 767
Query: 1896 KISRKRVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDVSLENVHT 1955
S SSDS +S S+ + + ++ ++ SD D S ++ +
Sbjct: 768 SDSSDSSDSSDSSNSSDSNDSSNSSDSS--------DSSNSSDSSNSSDSSD-SSDSSDS 818
Query: 1956 RSKNGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALN 2015
S N ++ SD S + S+ DS+ S + S +
Sbjct: 819 DSSN----------SSDSSNSSDSSDSSNSSDSSDS---SDSSDGSDSDSSNRSDSSNSS 865
Query: 2016 GDSDSEDMLNSEHKHRHTNIHKIDAPSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTL 2075
SDS D NS ++ ++ S SS +S + S S +D + SS+S+
Sbjct: 866 DSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSE 925
Query: 2076 AQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPEL 2135
+ ++ +N N + + + S + DS +++ +
Sbjct: 926 SSNSSDNSNSSDSSN------SSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDS 979
Query: 2136 ENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTDNT 2174
N S + +S D+S S+ S SD + N+
Sbjct: 980 SNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNS 1018
Score = 67.4 bits (163), Expect = 2e-10
Identities = 124/616 (20%), Positives = 218/616 (35%), Gaps = 59/616 (9%)
Query: 1263 NQHCTNISELSNTSEN----DEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNW 1318
+ + ++ S+ SN+S++ D N+ D DS SS D S ++N +SN
Sbjct: 728 SSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSND 787
Query: 1319 KKQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEF 1378
+ DS + + D D D+ + D+ N +
Sbjct: 788 SSNSSD-------SSDSSNSSDSSNSSDSSDSSDSSDSDSS-----NSSDSSNSSDSSDS 835
Query: 1379 CKDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRF 1438
S+ + + S S + S + SSD NE S
Sbjct: 836 SNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSS 895
Query: 1439 KQRQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISS 1498
+ DS + + + S + + S SS ++ S+ S
Sbjct: 896 DSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSD 955
Query: 1499 GVTSGDSSDSAESSERRKR-NRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRA 1557
S DSS+S++SS+ + +N S S+S + S SS SS S +S +SS +
Sbjct: 956 SSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1015
Query: 1558 RESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEI 1617
SS S S SSN + + + S ++ + SDS ++S +
Sbjct: 1016 SNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD--SSDSSDSSDSSDSS 1073
Query: 1618 LKARAGNNRKVLRKCAAVAANKIKLMSDVEENS-SSESVCSGRKLPHRNASAVARKKLLH 1676
+ + ++ + + ++ SD ++S SS+S S N+S +
Sbjct: 1074 DSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1133
Query: 1677 NSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHAN 1736
+S D + + E D + S S + + D S++ DS + SD ++
Sbjct: 1134 DSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD--------SSD 1185
Query: 1737 GYKSHTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPG 1796
S + S +SS+ S SD ++ S S + +E +DS
Sbjct: 1186 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSD-----SSDSSDSSDSSDSSDSNESSDSSDS 1240
Query: 1797 RSGGRKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAM 1856
N+ + S SDS DS S+ D D + SGN N
Sbjct: 1241 SDSSDSSNSSDSSDS--------SDSSDSTSDSNDESDSQSK-------SGNGN------ 1279
Query: 1857 SQCSSDHGCETDLDSD 1872
++G ++D DS+
Sbjct: 1280 -----NNGSDSDSDSE 1290
Score = 54.7 bits (130), Expect = 1e-06
Identities = 68/322 (21%), Positives = 124/322 (38%), Gaps = 32/322 (9%)
Query: 1447 DSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGVTSGDSS 1506
DS + N S + + S S SS ++ S+ S S DSS
Sbjct: 1008 DSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1067
Query: 1507 DSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSSRSGL 1566
DS++SS+ ++ S SES + S SS SS S +S +SS + +SS S
Sbjct: 1068 DSSDSSDS-------SDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1120
Query: 1567 SRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKARAGNNR 1626
S SS+ + + + +N + + SDS ++S + + + +
Sbjct: 1121 SNSSD-----SSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSD-- 1173
Query: 1627 KVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSEDEQSLKS 1686
++ ++N + + SS+S S ++S + +S D
Sbjct: 1174 ------SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1227
Query: 1687 EIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKSHTPAPS 1746
+ E D + S S + + D S++ DS S+S+ ++ NG + +
Sbjct: 1228 SSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGS---- 1283
Query: 1747 KTKFLKIESSEEDSKSHDSDHA 1768
S+ DS+ DS+H+
Sbjct: 1284 --------DSDSDSEGSDSNHS 1297
Score = 35.4 bits (80), Expect = 0.64
Identities = 20/47 (42%), Positives = 24/47 (51%)
Query: 816 SSGNESSSSVRHETSCDQSEGSGSSEEDEWRSDRKSESYSESSSDSS 862
S ++SS S S D S SE D SD KS+S +SSDSS
Sbjct: 605 SDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSS 651
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/52 (36%), Positives = 26/52 (50%)
Query: 816 SSGNESSSSVRHETSCDQSEGSGSSEEDEWRSDRKSESYSESSSDSSSRYSD 867
S ++SS+S S D S+ S SS+ + +SD S SDS S SD
Sbjct: 593 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSD 644
Score = 33.1 bits (74), Expect = 3.2
Identities = 20/49 (40%), Positives = 27/49 (55%), Gaps = 1/49 (2%)
Query: 816 SSGNESSSSVRHETSCDQSEGSGSSEEDEW-RSDRKSESYSESSSDSSS 863
S+ ++SS S S D S+ S S+ D RSD + S S SSDSS+
Sbjct: 827 SNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSN 875
Score = 32.0 bits (71), Expect = 7.1
Identities = 21/51 (41%), Positives = 26/51 (50%), Gaps = 2/51 (3%)
Query: 816 SSGNESSSSVRHETSCDQSEGSGSSEEDEWRSDRKSESYSESSSDSSSRYS 866
S + SS S S D S+ S SSE + S S+S S SSDSS+ S
Sbjct: 675 SDSSSSSDSSNSSDSSDSSDSSNSSESSD--SSDSSDSDSSDSSDSSNSNS 723
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 92.4 bits (228), Expect = 4e-18
Identities = 92/382 (24%), Positives = 159/382 (41%), Gaps = 62/382 (16%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
GH S V+ A++ + +GS D +IW+ ++ G LR GH
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236
Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
+++ + N + T++A GS D R+W + L H G I +L+++ KG+ Y+
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNK--KGN--YV 291
Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
+S G D T W K + F P V M A+ STD I
Sbjct: 292 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQ------NNMTFASCSTDMCIH 342
Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
+ LG + P K + HT++V++I++ +G S S D T +IW +Q
Sbjct: 343 VCRLGCDHPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 390
Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
D + + ++ I W N N SI++ + + D +++W+ G
Sbjct: 391 ------DACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVC 444
Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
H LM H + V+ + P D + + S D + IW+ G+ + Y QG G +F
Sbjct: 445 THTLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSY------QGTGGIF 497
Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
+ ++ G + S G + +
Sbjct: 498 EVCWNARGDKVGASASDGSVCV 519
Score = 50.8 bits (120), Expect = 1e-05
Identities = 41/154 (26%), Positives = 63/154 (40%), Gaps = 12/154 (7%)
Query: 358 PEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRIS 414
P K L H +V + D SGS D TARIW + ++L R
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228
Query: 415 G-DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFV 473
G D+ S ++ VT + WN + +++ D ++W G L L H +F
Sbjct: 229 GHDVPSNKD------VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFA 281
Query: 474 LETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
L+ + +LSAG D + IWD G + +
Sbjct: 282 LKWNK-KGNYVLSAGVDKTTIIWDAHTGEAKQQF 314
Score = 48.1 bits (113), Expect = 1e-04
Identities = 39/154 (25%), Positives = 70/154 (45%), Gaps = 15/154 (9%)
Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
G L CS T +M Q +H + H +Y + + TG + + S
Sbjct: 371 GMLLASCSDDMTLKIWSMKQDACVHD-LQAHSKEIYTIKWSPTGPATSNPNSSIMLASAS 429
Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
D V++W G TL H + +A + + +A+GS DK + +W ++ + V
Sbjct: 430 FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489
Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
QG TG I + ++ A+G + + ++ +DG+VC
Sbjct: 490 YQG-TGGIFEVCWN--ARGDK--VGASASDGSVC 518
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 92.4 bits (228), Expect = 4e-18
Identities = 92/382 (24%), Positives = 159/382 (41%), Gaps = 62/382 (16%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
GH S V+ A++ + +GS D +IW+ ++ G LR GH
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236
Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
+++ + N + T++A GS D R+W + L H G I +L+++ KG+ Y+
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNK--KGN--YV 291
Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
+S G D T W K + F P V M A+ STD I
Sbjct: 292 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQ------NNMTFASCSTDMCIH 342
Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
+ LG + P K + HT++V++I++ +G S S D T +IW +Q
Sbjct: 343 VCRLGCDHPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 390
Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
D + + ++ I W N N SI++ + + D +++W+ G
Sbjct: 391 ------DACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVC 444
Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
H LM H + V+ + P D + + S D + IW+ G+ + Y QG G +F
Sbjct: 445 THTLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSY------QGTGGIF 497
Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
+ ++ G + S G + +
Sbjct: 498 EVCWNARGDKVGASASDGSVCV 519
Score = 50.8 bits (120), Expect = 1e-05
Identities = 41/154 (26%), Positives = 63/154 (40%), Gaps = 12/154 (7%)
Query: 358 PEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRIS 414
P K L H +V + D SGS D TARIW + ++L R
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228
Query: 415 G-DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFV 473
G D+ S ++ VT + WN + +++ D ++W G L L H +F
Sbjct: 229 GHDVPSNKD------VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFA 281
Query: 474 LETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
L+ + +LSAG D + IWD G + +
Sbjct: 282 LKWNK-KGNYVLSAGVDKTTIIWDAHTGEAKQQF 314
Score = 48.1 bits (113), Expect = 1e-04
Identities = 39/154 (25%), Positives = 70/154 (45%), Gaps = 15/154 (9%)
Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
G L CS T +M Q +H + H +Y + + TG + + S
Sbjct: 371 GMLLASCSDDMTLKIWSMKQDACVHD-LQAHSKEIYTIKWSPTGPATSNPNSSIMLASAS 429
Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
D V++W G TL H + +A + + +A+GS DK + +W ++ + V
Sbjct: 430 FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489
Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
QG TG I + ++ A+G + + ++ +DG+VC
Sbjct: 490 YQG-TGGIFEVCWN--ARGDK--VGASASDGSVC 518
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 92.4 bits (228), Expect = 4e-18
Identities = 92/382 (24%), Positives = 159/382 (41%), Gaps = 62/382 (16%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
GH S V+ A++ + +GS D +IW+ ++ G LR GH
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236
Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
+++ + N + T++A GS D R+W + L H G I +L+++ KG+ Y+
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNK--KGN--YV 291
Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
+S G D T W K + F P V M A+ STD I
Sbjct: 292 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQ------NNMTFASCSTDMCIH 342
Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
+ LG + P K + HT++V++I++ +G S S D T +IW +Q
Sbjct: 343 VCRLGCDHPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 390
Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
D + + ++ I W N N SI++ + + D +++W+ G
Sbjct: 391 ------DACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVC 444
Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
H LM H + V+ + P D + + S D + IW+ G+ + Y QG G +F
Sbjct: 445 THTLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSY------QGTGGIF 497
Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
+ ++ G + S G + +
Sbjct: 498 EVCWNARGDKVGASASDGSVCV 519
Score = 50.8 bits (120), Expect = 1e-05
Identities = 41/154 (26%), Positives = 63/154 (40%), Gaps = 12/154 (7%)
Query: 358 PEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRIS 414
P K L H +V + D SGS D TARIW + ++L R
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228
Query: 415 G-DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFV 473
G D+ S ++ VT + WN + +++ D ++W G L L H +F
Sbjct: 229 GHDVPSNKD------VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFA 281
Query: 474 LETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
L+ + +LSAG D + IWD G + +
Sbjct: 282 LKWNK-KGNYVLSAGVDKTTIIWDAHTGEAKQQF 314
Score = 48.1 bits (113), Expect = 1e-04
Identities = 39/154 (25%), Positives = 70/154 (45%), Gaps = 15/154 (9%)
Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
G L CS T +M Q +H + H +Y + + TG + + S
Sbjct: 371 GMLLASCSDDMTLKIWSMKQDACVHD-LQAHSKEIYTIKWSPTGPATSNPNSSIMLASAS 429
Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
D V++W G TL H + +A + + +A+GS DK + +W ++ + V
Sbjct: 430 FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489
Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
QG TG I + ++ A+G + + ++ +DG+VC
Sbjct: 490 YQG-TGGIFEVCWN--ARGDK--VGASASDGSVC 518
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 90.9 bits (224), Expect = 1e-17
Identities = 81/320 (25%), Positives = 133/320 (41%), Gaps = 38/320 (11%)
Query: 225 RGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKG 284
+GH A I+ + ++ +A S D + +W + A GH +TS+QFSP
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHG-- 72
Query: 285 SQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGST 344
+ S D TV W D KF+E + FS G FLAT S
Sbjct: 73 --NLLASASRDRTVRLWIPDKRG--------KFSEFKAHTAPVRSVDFSADGQFLATASE 122
Query: 345 DHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRS 404
D I+++ + L HT V +F +G +S S D T +IW
Sbjct: 123 DKSIKVW--SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW--------- 171
Query: 405 ILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNL 464
D + + S+ F + +N + + + +A +D +KVW+ +LL +
Sbjct: 172 ---DTTNKQCVNNFSDSVGF----ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHY 224
Query: 465 MGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGH-GAVFDCK 523
H+ V + HP +++A DG++ I D+ +G + QGH G VF
Sbjct: 225 QVHSGGVNCISFHP-SGNYLITASSDGTLKILDLLEGRLIYTL------QGHTGPVFTVS 277
Query: 524 FSQDGQHFACTDSHGHLLIF 543
FS+ G+ FA + +L++
Sbjct: 278 FSKGGELFASGGADTQVLLW 297
Score = 75.5 bits (184), Expect = 6e-13
Identities = 60/223 (26%), Positives = 96/223 (43%), Gaps = 16/223 (7%)
Query: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
H + V V F G + T S+D +K+WS + R L +L H+ + + + +I
Sbjct: 101 HTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIV 160
Query: 245 AGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWD 304
+ S DK I++W V G + F+P S + S G+D TV W
Sbjct: 161 SCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNP----SGTCIASAGSDQTVKVWDVR 216
Query: 305 LESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAEL 364
+ L L+ + GV C SF G +L T S+D +++ L I L
Sbjct: 217 VNKL------LQHYQVHSGGVN--CISFHPSGNYLITASSDGTLKI--LDLLEGRLIYTL 266
Query: 365 ESHTDKVDSIQFCNNGDRFLSGSRDGTARIWR--FEQLEWRSI 405
+ HT V ++ F G+ F SG D +WR F++L + +
Sbjct: 267 QGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGL 309
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 90.1 bits (222), Expect = 2e-17
Identities = 97/385 (25%), Positives = 163/385 (42%), Gaps = 60/385 (15%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMI 243
GH AV VAF TG + +GS D V+ W T +GH + ++ + + +
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKL 171
Query: 244 AAGSCDKIIRVWCLRTCAPVA-VLQGHTGSITSLQFSPM-AKGSQRYMVSTGADGTVCFW 301
A+G + I +W T V L GH+ IT L + P+ A RY+ S+ DG+V W
Sbjct: 172 ASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIW 231
Query: 302 ---------------------QWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLA 340
+W + L +S + + R +LC + G ++
Sbjct: 232 DTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVN 291
Query: 341 TG--STDHVIRMYFLGFEAPE----------KIAELESHTDKVDSIQFCNNGDRFLSGSR 388
T STD+ +R FE E + EL+ ++ +R +SGS
Sbjct: 292 TMALSTDYALRTG--AFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSD 349
Query: 389 DGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDH 448
D T +W E + L TR++G + + + ++ + IV +A D
Sbjct: 350 DFTLFLW--SPAEDKKPL----TRMTGH---------QALINQVLFSPDSRIVASASFDK 394
Query: 449 VLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYF 508
+K+W+ TG+ L +L GH V+ + DSR+++S D ++ +WD+ K K+
Sbjct: 395 SIKLWDGRTGKYLASLRGHVAAVYQI-AWSADSRLLVSGSSDSTLKVWDV-KAQKL---- 448
Query: 509 NMIEGQGHG-AVFDCKFSQDGQHFA 532
++ GH V+ +S DGQ A
Sbjct: 449 -AMDLPGHADEVYAVDWSPDGQRVA 472
Score = 64.7 bits (156), Expect = 1e-09
Identities = 87/367 (23%), Positives = 149/367 (40%), Gaps = 48/367 (13%)
Query: 219 RLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQF 278
R S+L GHS + +A + +A+GS D +R W L T P +GH + S+ +
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
Query: 279 SPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMF 338
SP R + S +G + WD + K R L K G+ + +
Sbjct: 165 SP----DGRKLASGCKNGQILL--WDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRY 218
Query: 339 LATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFE 398
+A+ S D +R++ E+I L HT V +++ +G S S+D T ++WR
Sbjct: 219 VASSSKDGSVRIWDTTAGRCERI--LTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAH 275
Query: 399 Q-------------LEWRSILLDMATR---------------ISGDLSSEEERFMKPKVT 430
+ ++ D A R + G L +ER + +
Sbjct: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALS-RYN 334
Query: 431 MIAWNQNDSIVVTAVNDHVLKVWN-SYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGH 489
++ Q +V+ +D L +W+ + + L + GH + + P DSRI+ SA
Sbjct: 335 LVR-GQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASF 392
Query: 490 DGSIFIWDITKGTKMKHYFNMIEGQGH-GAVFDCKFSQDGQHFACTDSHGHLLIFGFGCS 548
D SI +WD G K+ ++ +GH AV+ +S D + S L ++
Sbjct: 393 DKSIKLWD---GRTGKYLASL---RGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446
Query: 549 KPYEKIP 555
K +P
Sbjct: 447 KLAMDLP 453
Score = 64.3 bits (155), Expect = 1e-09
Identities = 57/264 (21%), Positives = 105/264 (39%), Gaps = 60/264 (22%)
Query: 177 KMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAV 236
+ R + GH +V C+ + G +++ S D +K+W H+G L TL+GH ++ MA+
Sbjct: 237 RCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMAL 295
Query: 237 NYENTM------------------------------------------IAAGSCDKIIRV 254
+ + + + +GS D + +
Sbjct: 296 STDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFL 355
Query: 255 WC-LRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPR 313
W P+ + GH I + FSP R + S D ++ W R
Sbjct: 356 WSPAEDKKPLTRMTGHQALINQVLFSP----DSRIVASASFDKSIKLWDG---------R 402
Query: 314 PLKFTEKPRPGVQMLCS-SFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVD 372
K+ R V + ++S L +GS+D ++++ + +A + +L H D+V
Sbjct: 403 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV--KAQKLAMDLPGHADEVY 460
Query: 373 SIQFCNNGDRFLSGSRDGTARIWR 396
++ + +G R SG +D RIWR
Sbjct: 461 AVDWSPDGQRVASGGKDKCLRIWR 484
Score = 62.4 bits (150), Expect = 5e-09
Identities = 41/155 (26%), Positives = 74/155 (47%), Gaps = 4/155 (2%)
Query: 148 NLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDD 207
NLV ++L S T F + + K R+ GH + + V F + + S D
Sbjct: 334 NLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFD 393
Query: 208 CLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQ 267
+K+W G+ L++LRGH A + +A + ++ ++ +GS D ++VW ++ L
Sbjct: 394 KSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLP 453
Query: 268 GHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQ 302
GH + ++ +SP QR + S G D + W+
Sbjct: 454 GHADEVYAVDWSP---DGQR-VASGGKDKCLRIWR 484
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 88.2 bits (217), Expect = 8e-17
Identities = 73/288 (25%), Positives = 131/288 (45%), Gaps = 36/288 (12%)
Query: 182 ILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEIS--DMAVNYE 239
I H V C AF I T S D VKIW++ G L+ T HS +++ +
Sbjct: 653 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 712
Query: 240 NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
+ ++A GS D +++W L + GHT S+ +FSP + + S ADGT+
Sbjct: 713 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSP----DDKLLASCSADGTLK 768
Query: 300 FWQWDLESLKFSPRPLKF---TEKPRPGVQML--CSSFSVGGMFLATGSTDHVIRMYFLG 354
W + + S +F E P+ ++++ C S+S G + + + +++
Sbjct: 769 LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN---KIFLWN 825
Query: 355 FEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRIS 414
++ K+A+ H V + F +G FL+ S D T R+W +++ S ++
Sbjct: 826 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVM------- 878
Query: 415 GDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHV--LKVWNSYTGQL 460
+K +V ++ Q + ++V AV DH+ L++ N TGQ+
Sbjct: 879 ----------LKQEVDVVF--QENEVMVLAV-DHIRRLQLINGRTGQI 913
Score = 56.2 bits (134), Expect = 4e-07
Identities = 46/195 (23%), Positives = 81/195 (41%), Gaps = 22/195 (11%)
Query: 367 HTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMK 426
HTD V F +G R S D T ++++ E E LL++ +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEK---LLEIKAH-------------E 657
Query: 427 PKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLS 486
+V A++ +D + T D +K+WNS TG+L+H H+++V ++L+
Sbjct: 658 DEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLA 717
Query: 487 AG-HDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGF 545
G D + +WD+ + F H C+FS D + A + G L ++
Sbjct: 718 TGSSDCFLKLWDLNQKECRNTMFGHTNSVNH-----CRFSPDDKLLASCSADGTLKLWDA 772
Query: 546 GCSKPYEKIPDQMFF 560
+ + I + FF
Sbjct: 773 TSANERKSINVKQFF 787
Score = 54.7 bits (130), Expect = 1e-06
Identities = 77/370 (20%), Positives = 136/370 (36%), Gaps = 80/370 (21%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNG------------------------- 218
GHLS V+ V F G T SDD +++W T
Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 896
Query: 219 ----RLLSTLRGHS--------AEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVL 266
R L + G + A++S ++ IA G + I + L
Sbjct: 897 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 956
Query: 267 QGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQ 326
H ++ +QF+ ++ ++S+ D + W W L+ F L+ ++ +
Sbjct: 957 FQHKKTVWHIQFT----ADEKTLISSSDDAEIQVWNWQLDKCIF----LRGHQETVKDFR 1008
Query: 327 MLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSG 386
+L +S + F T ++I K + H V S ++ +F S
Sbjct: 1009 LLKNSRLLSWSFDGTVKVWNII--------TGNKEKDFVCHQGTVLSCDISHDATKFSST 1060
Query: 387 SRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVN 446
S D TA+IW F+ L L E R V A++ + +++ T +
Sbjct: 1061 SADKTAKIWSFDLL----------------LPLHELRGHNGCVRCSAFSVDSTLLATGDD 1104
Query: 447 DHVLKVWNSYTGQLLH--------NLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDI 498
+ +++WN G+LLH H V L P D ++++SAG G I W++
Sbjct: 1105 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP-DGKMLISAG--GYIKWWNV 1161
Query: 499 TKGTKMKHYF 508
G + ++
Sbjct: 1162 VTGESSQTFY 1171
Score = 49.7 bits (117), Expect = 3e-05
Identities = 58/282 (20%), Positives = 115/282 (40%), Gaps = 21/282 (7%)
Query: 224 LRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAK 283
+R H+ + + + IA+ DK ++V+ T + ++ H + FS
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFST--- 667
Query: 284 GSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSF--SVGGMFLAT 341
R++ + D V W L + + E Q+ C F S + LAT
Sbjct: 668 -DDRFIATCSVDKKVKIWNSMTGELVHT-----YDEHSE---QVNCCHFTNSSHHLLLAT 718
Query: 342 GSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE 401
GS+D ++++ L E + HT+ V+ +F + S S DGT ++W
Sbjct: 719 GSSDCFLKLWDL--NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSAN 776
Query: 402 WRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLL 461
R + ++ + E+ M+ V +W+ + + ++ A + + +WN+ + +
Sbjct: 777 ERKSINVKQFFLNLEDPQED---MEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKV 832
Query: 462 HNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTK 503
+ GH V + P D L++ D +I +W+ K K
Sbjct: 833 ADCRGHLSWVHGVMFSP-DGSSFLTSSDDQTIRLWETKKVCK 873
Score = 49.3 bits (116), Expect = 4e-05
Identities = 48/207 (23%), Positives = 90/207 (43%), Gaps = 29/207 (14%)
Query: 332 FSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSG-SRDG 390
FS G +A+ D ++++ E EK+ E+++H D+V F + DRF++ S D
Sbjct: 623 FSEDGQRIASCGADKTLQVFKA--ETGEKLLEIKAHEDEVLCCAF-STDDRFIATCSVDK 679
Query: 391 TARIWRFEQLEWRSILLDMATRISGDL-SSEEERFMKPKVTMIAWNQNDSIVVTAVNDHV 449
+IW ++G+L + +E + + + ++ T +D
Sbjct: 680 KVKIW---------------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 724
Query: 450 LKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDIT-----KGTKM 504
LK+W+ + + + GH + V P D +++ S DG++ +WD T K +
Sbjct: 725 LKLWDLNQKECRNTMFGHTNSVNHCRFSP-DDKLLASCSADGTLKLWDATSANERKSINV 783
Query: 505 KHYFNMIEGQGHG---AVFDCKFSQDG 528
K +F +E V C +S DG
Sbjct: 784 KQFFLNLEDPQEDMEVIVKCCSWSADG 810
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 88.2 bits (217), Expect = 8e-17
Identities = 73/288 (25%), Positives = 131/288 (45%), Gaps = 36/288 (12%)
Query: 182 ILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEIS--DMAVNYE 239
I H V C AF I T S D VKIW++ G L+ T HS +++ +
Sbjct: 642 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 701
Query: 240 NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
+ ++A GS D +++W L + GHT S+ +FSP + + S ADGT+
Sbjct: 702 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSP----DDKLLASCSADGTLK 757
Query: 300 FWQWDLESLKFSPRPLKF---TEKPRPGVQML--CSSFSVGGMFLATGSTDHVIRMYFLG 354
W + + S +F E P+ ++++ C S+S G + + + +++
Sbjct: 758 LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN---KIFLWN 814
Query: 355 FEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRIS 414
++ K+A+ H V + F +G FL+ S D T R+W +++ S ++
Sbjct: 815 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVM------- 867
Query: 415 GDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHV--LKVWNSYTGQL 460
+K +V ++ Q + ++V AV DH+ L++ N TGQ+
Sbjct: 868 ----------LKQEVDVVF--QENEVMVLAV-DHIRRLQLINGRTGQI 902
Score = 56.2 bits (134), Expect = 4e-07
Identities = 46/195 (23%), Positives = 81/195 (41%), Gaps = 22/195 (11%)
Query: 367 HTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMK 426
HTD V F +G R S D T ++++ E E LL++ +
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEK---LLEIKAH-------------E 646
Query: 427 PKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLS 486
+V A++ +D + T D +K+WNS TG+L+H H+++V ++L+
Sbjct: 647 DEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLA 706
Query: 487 AG-HDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGF 545
G D + +WD+ + F H C+FS D + A + G L ++
Sbjct: 707 TGSSDCFLKLWDLNQKECRNTMFGHTNSVNH-----CRFSPDDKLLASCSADGTLKLWDA 761
Query: 546 GCSKPYEKIPDQMFF 560
+ + I + FF
Sbjct: 762 TSANERKSINVKQFF 776
Score = 54.7 bits (130), Expect = 1e-06
Identities = 77/370 (20%), Positives = 136/370 (36%), Gaps = 80/370 (21%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNG------------------------- 218
GHLS V+ V F G T SDD +++W T
Sbjct: 826 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 885
Query: 219 ----RLLSTLRGHS--------AEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVL 266
R L + G + A++S ++ IA G + I + L
Sbjct: 886 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 945
Query: 267 QGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQ 326
H ++ +QF+ ++ ++S+ D + W W L+ F L+ ++ +
Sbjct: 946 FQHKKTVWHIQFT----ADEKTLISSSDDAEIQVWNWQLDKCIF----LRGHQETVKDFR 997
Query: 327 MLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSG 386
+L +S + F T ++I K + H V S ++ +F S
Sbjct: 998 LLKNSRLLSWSFDGTVKVWNII--------TGNKEKDFVCHQGTVLSCDISHDATKFSST 1049
Query: 387 SRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVN 446
S D TA+IW F+ L L E R V A++ + +++ T +
Sbjct: 1050 SADKTAKIWSFDLL----------------LPLHELRGHNGCVRCSAFSVDSTLLATGDD 1093
Query: 447 DHVLKVWNSYTGQLLH--------NLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDI 498
+ +++WN G+LLH H V L P D ++++SAG G I W++
Sbjct: 1094 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP-DGKMLISAG--GYIKWWNV 1150
Query: 499 TKGTKMKHYF 508
G + ++
Sbjct: 1151 VTGESSQTFY 1160
Score = 49.7 bits (117), Expect = 3e-05
Identities = 58/282 (20%), Positives = 115/282 (40%), Gaps = 21/282 (7%)
Query: 224 LRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAK 283
+R H+ + + + IA+ DK ++V+ T + ++ H + FS
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFST--- 656
Query: 284 GSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSF--SVGGMFLAT 341
R++ + D V W L + + E Q+ C F S + LAT
Sbjct: 657 -DDRFIATCSVDKKVKIWNSMTGELVHT-----YDEHSE---QVNCCHFTNSSHHLLLAT 707
Query: 342 GSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE 401
GS+D ++++ L E + HT+ V+ +F + S S DGT ++W
Sbjct: 708 GSSDCFLKLWDL--NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSAN 765
Query: 402 WRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLL 461
R + ++ + E+ M+ V +W+ + + ++ A + + +WN+ + +
Sbjct: 766 ERKSINVKQFFLNLEDPQED---MEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKV 821
Query: 462 HNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTK 503
+ GH V + P D L++ D +I +W+ K K
Sbjct: 822 ADCRGHLSWVHGVMFSP-DGSSFLTSSDDQTIRLWETKKVCK 862
Score = 49.3 bits (116), Expect = 4e-05
Identities = 48/207 (23%), Positives = 90/207 (43%), Gaps = 29/207 (14%)
Query: 332 FSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSG-SRDG 390
FS G +A+ D ++++ E EK+ E+++H D+V F + DRF++ S D
Sbjct: 612 FSEDGQRIASCGADKTLQVFKA--ETGEKLLEIKAHEDEVLCCAF-STDDRFIATCSVDK 668
Query: 391 TARIWRFEQLEWRSILLDMATRISGDL-SSEEERFMKPKVTMIAWNQNDSIVVTAVNDHV 449
+IW ++G+L + +E + + + ++ T +D
Sbjct: 669 KVKIW---------------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 713
Query: 450 LKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDIT-----KGTKM 504
LK+W+ + + + GH + V P D +++ S DG++ +WD T K +
Sbjct: 714 LKLWDLNQKECRNTMFGHTNSVNHCRFSP-DDKLLASCSADGTLKLWDATSANERKSINV 772
Query: 505 KHYFNMIEGQGHG---AVFDCKFSQDG 528
K +F +E V C +S DG
Sbjct: 773 KQFFLNLEDPQEDMEVIVKCCSWSADG 799
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 84.0 bits (206), Expect = 2e-15
Identities = 87/382 (22%), Positives = 158/382 (41%), Gaps = 62/382 (16%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
GH S V+ A++ + +GS D +IW+ ++ G LR GH
Sbjct: 179 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 238
Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
+++ + N T++A GS D R+W + L H G I +L+++ KG+ Y+
Sbjct: 239 DVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWN--RKGN--YI 293
Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
+S G D T W K + F P V ++ A+ STD I
Sbjct: 294 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQNNTT------FASCSTDMCIH 344
Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
+ LG + P K + HT++V++I++ +G S S D T +IW +Q
Sbjct: 345 VCRLGCDRPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 392
Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
++ + + ++ I W N N +I++ + + D +++W+ G
Sbjct: 393 ------EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 446
Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
H L H + V+ + P D + + S D + IW+ G + Y +G G +F
Sbjct: 447 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQSGNLVHSY------RGTGGIF 499
Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
+ ++ G + S G + +
Sbjct: 500 EVCWNARGDKVGASASDGSVCV 521
Score = 51.2 bits (121), Expect = 1e-05
Identities = 42/152 (27%), Positives = 63/152 (41%), Gaps = 12/152 (7%)
Query: 360 KIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRISG- 415
K L H +V + D SGS D TARIW + ++L R G
Sbjct: 173 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 232
Query: 416 DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLE 475
D+ S ++ VT + WN N +++ T D ++W G L L H +F L+
Sbjct: 233 DVPSNKD------VTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALK 285
Query: 476 THPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
+ +LSAG D + IWD G + +
Sbjct: 286 WNR-KGNYILSAGVDKTTIIWDAHTGEAKQQF 316
Score = 46.6 bits (109), Expect = 3e-04
Identities = 38/154 (24%), Positives = 70/154 (45%), Gaps = 15/154 (9%)
Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
G L CS T +M Q + +H + H +Y + + TG + + S
Sbjct: 373 GMLLASCSDDMTLKIWSMKQEVCIHD-LQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 431
Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
D V++W G TL H + +A + + +A+GS DK + +W ++ V
Sbjct: 432 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 491
Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
+G TG I + ++ A+G + + ++ +DG+VC
Sbjct: 492 YRG-TGGIFEVCWN--ARGDK--VGASASDGSVC 520
Score = 40.4 bits (93), Expect = 0.020
Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 1/74 (1%)
Query: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
H VY VAF G + +GS D V IW+T +G L+ + RG + I ++ N +
Sbjct: 453 HQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVG 511
Query: 245 AGSCDKIIRVWCLR 258
A + D + V LR
Sbjct: 512 ASASDGSVCVLDLR 525
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 84.0 bits (206), Expect = 2e-15
Identities = 87/382 (22%), Positives = 158/382 (41%), Gaps = 62/382 (16%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
GH S V+ A++ + +GS D +IW+ ++ G LR GH
Sbjct: 179 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 238
Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
+++ + N T++A GS D R+W + L H G I +L+++ KG+ Y+
Sbjct: 239 DVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWN--RKGN--YI 293
Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
+S G D T W K + F P V ++ A+ STD I
Sbjct: 294 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQNNTT------FASCSTDMCIH 344
Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
+ LG + P K + HT++V++I++ +G S S D T +IW +Q
Sbjct: 345 VCRLGCDRPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 392
Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
++ + + ++ I W N N +I++ + + D +++W+ G
Sbjct: 393 ------EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 446
Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
H L H + V+ + P D + + S D + IW+ G + Y +G G +F
Sbjct: 447 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQSGNLVHSY------RGTGGIF 499
Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
+ ++ G + S G + +
Sbjct: 500 EVCWNARGDKVGASASDGSVCV 521
Score = 51.2 bits (121), Expect = 1e-05
Identities = 42/152 (27%), Positives = 63/152 (41%), Gaps = 12/152 (7%)
Query: 360 KIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRISG- 415
K L H +V + D SGS D TARIW + ++L R G
Sbjct: 173 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 232
Query: 416 DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLE 475
D+ S ++ VT + WN N +++ T D ++W G L L H +F L+
Sbjct: 233 DVPSNKD------VTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALK 285
Query: 476 THPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
+ +LSAG D + IWD G + +
Sbjct: 286 WNR-KGNYILSAGVDKTTIIWDAHTGEAKQQF 316
Score = 46.6 bits (109), Expect = 3e-04
Identities = 38/154 (24%), Positives = 70/154 (45%), Gaps = 15/154 (9%)
Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
G L CS T +M Q + +H + H +Y + + TG + + S
Sbjct: 373 GMLLASCSDDMTLKIWSMKQEVCIHD-LQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 431
Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
D V++W G TL H + +A + + +A+GS DK + +W ++ V
Sbjct: 432 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 491
Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
+G TG I + ++ A+G + + ++ +DG+VC
Sbjct: 492 YRG-TGGIFEVCWN--ARGDK--VGASASDGSVC 520
Score = 40.4 bits (93), Expect = 0.020
Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 1/74 (1%)
Query: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
H VY VAF G + +GS D V IW+T +G L+ + RG + I ++ N +
Sbjct: 453 HQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVG 511
Query: 245 AGSCDKIIRVWCLR 258
A + D + V LR
Sbjct: 512 ASASDGSVCVLDLR 525
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 84.0 bits (206), Expect = 2e-15
Identities = 87/382 (22%), Positives = 158/382 (41%), Gaps = 62/382 (16%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
GH S V+ A++ + +GS D +IW+ ++ G LR GH
Sbjct: 230 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 289
Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
+++ + N T++A GS D R+W + L H G I +L+++ KG+ Y+
Sbjct: 290 DVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWN--RKGN--YI 344
Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
+S G D T W K + F P V ++ A+ STD I
Sbjct: 345 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQNNTT------FASCSTDMCIH 395
Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
+ LG + P K + HT++V++I++ +G S S D T +IW +Q
Sbjct: 396 VCRLGCDRPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 443
Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
++ + + ++ I W N N +I++ + + D +++W+ G
Sbjct: 444 ------EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 497
Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
H L H + V+ + P D + + S D + IW+ G + Y +G G +F
Sbjct: 498 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQSGNLVHSY------RGTGGIF 550
Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
+ ++ G + S G + +
Sbjct: 551 EVCWNARGDKVGASASDGSVCV 572
Score = 51.2 bits (121), Expect = 1e-05
Identities = 42/152 (27%), Positives = 63/152 (41%), Gaps = 12/152 (7%)
Query: 360 KIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRISG- 415
K L H +V + D SGS D TARIW + ++L R G
Sbjct: 224 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 283
Query: 416 DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLE 475
D+ S ++ VT + WN N +++ T D ++W G L L H +F L+
Sbjct: 284 DVPSNKD------VTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALK 336
Query: 476 THPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
+ +LSAG D + IWD G + +
Sbjct: 337 WNR-KGNYILSAGVDKTTIIWDAHTGEAKQQF 367
Score = 46.6 bits (109), Expect = 3e-04
Identities = 38/154 (24%), Positives = 70/154 (45%), Gaps = 15/154 (9%)
Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
G L CS T +M Q + +H + H +Y + + TG + + S
Sbjct: 424 GMLLASCSDDMTLKIWSMKQEVCIHD-LQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 482
Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
D V++W G TL H + +A + + +A+GS DK + +W ++ V
Sbjct: 483 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 542
Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
+G TG I + ++ A+G + + ++ +DG+VC
Sbjct: 543 YRG-TGGIFEVCWN--ARGDK--VGASASDGSVC 571
Score = 40.4 bits (93), Expect = 0.020
Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 1/74 (1%)
Query: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
H VY VAF G + +GS D V IW+T +G L+ + RG + I ++ N +
Sbjct: 504 HQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVG 562
Query: 245 AGSCDKIIRVWCLR 258
A + D + V LR
Sbjct: 563 ASASDGSVCVLDLR 576
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 84.0 bits (206), Expect = 2e-15
Identities = 87/382 (22%), Positives = 158/382 (41%), Gaps = 62/382 (16%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
GH S V+ A++ + +GS D +IW+ ++ G LR GH
Sbjct: 230 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 289
Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
+++ + N T++A GS D R+W + L H G I +L+++ KG+ Y+
Sbjct: 290 DVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWN--RKGN--YI 344
Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
+S G D T W K + F P V ++ A+ STD I
Sbjct: 345 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQNNTT------FASCSTDMCIH 395
Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
+ LG + P K + HT++V++I++ +G S S D T +IW +Q
Sbjct: 396 VCRLGCDRPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 443
Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
++ + + ++ I W N N +I++ + + D +++W+ G
Sbjct: 444 ------EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 497
Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
H L H + V+ + P D + + S D + IW+ G + Y +G G +F
Sbjct: 498 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQSGNLVHSY------RGTGGIF 550
Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
+ ++ G + S G + +
Sbjct: 551 EVCWNARGDKVGASASDGSVCV 572
Score = 51.2 bits (121), Expect = 1e-05
Identities = 42/152 (27%), Positives = 63/152 (41%), Gaps = 12/152 (7%)
Query: 360 KIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRISG- 415
K L H +V + D SGS D TARIW + ++L R G
Sbjct: 224 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 283
Query: 416 DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLE 475
D+ S ++ VT + WN N +++ T D ++W G L L H +F L+
Sbjct: 284 DVPSNKD------VTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALK 336
Query: 476 THPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
+ +LSAG D + IWD G + +
Sbjct: 337 WNR-KGNYILSAGVDKTTIIWDAHTGEAKQQF 367
Score = 46.6 bits (109), Expect = 3e-04
Identities = 38/154 (24%), Positives = 70/154 (45%), Gaps = 15/154 (9%)
Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
G L CS T +M Q + +H + H +Y + + TG + + S
Sbjct: 424 GMLLASCSDDMTLKIWSMKQEVCIHD-LQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 482
Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
D V++W G TL H + +A + + +A+GS DK + +W ++ V
Sbjct: 483 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 542
Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
+G TG I + ++ A+G + + ++ +DG+VC
Sbjct: 543 YRG-TGGIFEVCWN--ARGDK--VGASASDGSVC 571
Score = 40.4 bits (93), Expect = 0.020
Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 1/74 (1%)
Query: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
H VY VAF G + +GS D V IW+T +G L+ + RG + I ++ N +
Sbjct: 504 HQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVG 562
Query: 245 AGSCDKIIRVWCLR 258
A + D + V LR
Sbjct: 563 ASASDGSVCVLDLR 576
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 83.2 bits (204), Expect = 3e-15
Identities = 86/382 (22%), Positives = 159/382 (41%), Gaps = 62/382 (16%)
Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLRG----------HSA 229
GH S V+ A++ + +GS D +IW+ + +G LR +
Sbjct: 167 GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNK 226
Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
+++ + N E T++A GS D R+W + + L H G I +L+++ KG+ ++
Sbjct: 227 DVTSLDWNSEGTLLATGSYDGFARIWT-KDGNLASTLGQHKGPIFALKWNK--KGN--FI 281
Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
+S G D T W K + F P V ++ A+ STD I
Sbjct: 282 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQSNNT------FASCSTDMCIH 332
Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
+ LG + P I + HT++V++I++ G+ S S D T +IW +Q
Sbjct: 333 VCKLGQDRP--IKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQ---------- 380
Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
D + + ++ I W N N ++++ + + D +++W+ G
Sbjct: 381 ------DNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGIC 434
Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
+H L H + V+ + P D R + S D + IW+ G + Y +G G +F
Sbjct: 435 IHTLTKHQEPVYSVAFSP-DGRYLASGSFDKCVHIWNTQTGALVHSY------RGTGGIF 487
Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
+ ++ G + S G + +
Sbjct: 488 EVCWNAAGDKVGASASDGSVCV 509
Score = 53.1 bits (126), Expect = 3e-06
Identities = 42/154 (27%), Positives = 63/154 (40%), Gaps = 12/154 (7%)
Query: 358 PEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEW---RSILLDMATRIS 414
P K L H +V + D SGS D TARIW + ++L R
Sbjct: 159 PNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREG 218
Query: 415 G-DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFV 473
G D+ S ++ VT + WN +++ T D ++W G L L H +F
Sbjct: 219 GQDVPSNKD------VTSLDWNSEGTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFA 271
Query: 474 LETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
L+ + +LSAG D + IWD G + +
Sbjct: 272 LKWNK-KGNFILSAGVDKTTIIWDAHTGEAKQQF 304
Score = 48.1 bits (113), Expect = 1e-04
Identities = 40/154 (25%), Positives = 70/154 (45%), Gaps = 15/154 (9%)
Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGH---------RIFTGS 205
G L CS T +M Q +H + H +Y + + TG + + S
Sbjct: 361 GNLLASCSDDMTLKIWSMKQDNCVHD-LQAHNKEIYTIKWSPTGPGTNNPNANLMLASAS 419
Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
D V++W G + TL H + +A + + +A+GS DK + +W +T A V
Sbjct: 420 FDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHS 479
Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
+G TG I + ++ A G + + ++ +DG+VC
Sbjct: 480 YRG-TGGIFEVCWN--AAGDK--VGASASDGSVC 508
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 80.9 bits (198), Expect = 1e-14
Identities = 56/241 (23%), Positives = 109/241 (45%), Gaps = 31/241 (12%)
Query: 267 QGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQ 326
+GH ++T + FS K + S D + W +K R +FT
Sbjct: 16 KGHRDAVTCVDFSINTK----QLASGSMDSCLMVWH-----MKPQSRAYRFTGHKDA--- 63
Query: 327 MLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSG 386
+ C +FS G LA+GS D +R++ + + +HT V S+ FC++G F++
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQSFVTA 121
Query: 387 SRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVN 446
S D T ++W + + L ++ I+ V ++ + ++V+A +
Sbjct: 122 SDDKTVKVWATHR---QKFLFSLSQHINW-------------VRCAKFSPDGRLIVSASD 165
Query: 447 DHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKH 506
D +K+W+ + + +H+ H V ++ HP + I +AG D ++ +WD+ ++H
Sbjct: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIA-AAGMDNTVKVWDVRTHRLLQH 224
Query: 507 Y 507
Y
Sbjct: 225 Y 225
Score = 77.4 bits (189), Expect = 1e-13
Identities = 65/320 (20%), Positives = 123/320 (38%), Gaps = 33/320 (10%)
Query: 178 MHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVN 237
+ R GH AV CV F ++ +GS D + +W GH ++ + +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 238 YENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGT 297
++A+GS DK +R+W V + HT ++ S+ F + V+ D T
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFC----SDGQSFVTASDDKT 126
Query: 298 VCFWQWDLESLKFS-PRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFE 356
V W + FS + + + C+ FS G + + S D ++++
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVR---------CAKFSPDGRLIVSASDDKTVKLW--DKS 175
Query: 357 APEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGD 416
+ E + H V + F +G + D T ++W D+ T
Sbjct: 176 SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW------------DVRTH---- 219
Query: 417 LSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLET 476
+ + V ++++ + + ++TA +D LK+ + G+LL+ L GH +
Sbjct: 220 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV-A 278
Query: 477 HPFDSRIMLSAGHDGSIFIW 496
S G D + +W
Sbjct: 279 FSRTGEYFASGGSDEQVMVW 298
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,141,331
Number of Sequences: 37866
Number of extensions: 4225588
Number of successful extensions: 23114
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 346
Number of HSP's successfully gapped in prelim test: 494
Number of HSP's that attempted gapping in prelim test: 14865
Number of HSP's gapped (non-prelim): 5670
length of query: 2269
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2151
effective length of database: 13,779,330
effective search space: 29639338830
effective search space used: 29639338830
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.