Guide to the Human Genome
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Search of human proteins with 16445438

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16445438 bromodomain and WD repeat domain containing 1
isoform B [Homo sapiens]
         (2269 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16445438 bromodomain and WD repeat domain containing 1 isofor...  4583   0.0  
gi|16445436 bromodomain and WD repeat domain containing 1 isofor...  4424   0.0  
gi|153791630 bromodomain and WD repeat domain containing 3 [Homo...  1882   0.0  
gi|34996489 pleckstrin homology domain interacting protein [Homo...  1826   0.0  
gi|55956930 bromodomain and WD repeat domain containing 1 isofor...   232   3e-60
gi|32189425 WD repeat domain 69 [Homo sapiens]                        116   2e-25
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   103   1e-21
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   103   1e-21
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   103   1e-21
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]   103   1e-21
gi|23199987 WD repeat domain 5B [Homo sapiens]                        103   1e-21
gi|16554629 WD repeat domain 5 [Homo sapiens]                          99   6e-20
gi|16554627 WD repeat domain 5 [Homo sapiens]                          99   6e-20
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     98   8e-20
gi|113865883 WD repeat domain 38 [Homo sapiens]                        98   8e-20
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     94   2e-18
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    93   3e-18
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     92   4e-18
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     92   4e-18
gi|15150805 transducin beta-like 1Y [Homo sapiens]                     92   4e-18
gi|26665869 WD repeat domain 51B [Homo sapiens]                        91   1e-17
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            90   2e-17
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...    88   8e-17
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...    88   8e-17
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          84   2e-15
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          84   2e-15
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          84   2e-15
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            84   2e-15
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    83   3e-15
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             81   1e-14

>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
            [Homo sapiens]
          Length = 2269

 Score = 4583 bits (11887), Expect = 0.0
 Identities = 2269/2269 (100%), Positives = 2269/2269 (100%)

Query: 1    MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN 60
            MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN
Sbjct: 1    MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN 60

Query: 61   RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRH 120
            RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRH
Sbjct: 61   RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRH 120

Query: 121  TVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR 180
            TVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR
Sbjct: 121  TVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR 180

Query: 181  RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN 240
            RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN
Sbjct: 181  RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN 240

Query: 241  TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCF 300
            TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCF
Sbjct: 241  TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCF 300

Query: 301  WQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK 360
            WQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK
Sbjct: 301  WQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK 360

Query: 361  IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSE 420
            IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSE
Sbjct: 361  IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSE 420

Query: 421  EERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFD 480
            EERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFD
Sbjct: 421  EERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFD 480

Query: 481  SRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL 540
            SRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL
Sbjct: 481  SRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL 540

Query: 541  LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPH 600
            LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPH
Sbjct: 541  LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPH 600

Query: 601  PTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIR 660
            PTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIR
Sbjct: 601  PTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIR 660

Query: 661  QLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH 720
            QLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH
Sbjct: 661  QLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH 720

Query: 721  QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQL 780
            QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQL
Sbjct: 721  QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQL 780

Query: 781  SHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSS 840
            SHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSS
Sbjct: 781  SHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSS 840

Query: 841  EEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIS 900
            EEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIS
Sbjct: 841  EEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIS 900

Query: 901  TENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQ 960
            TENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQ
Sbjct: 901  TENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQ 960

Query: 961  MGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLC 1020
            MGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLC
Sbjct: 961  MGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLC 1020

Query: 1021 CLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDA 1080
            CLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDA
Sbjct: 1021 CLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDA 1080

Query: 1081 WWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISV 1140
            WWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISV
Sbjct: 1081 WWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISV 1140

Query: 1141 TTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTV 1200
            TTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTV
Sbjct: 1141 TTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTV 1200

Query: 1201 VAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKF 1260
            VAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKF
Sbjct: 1201 VAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKF 1260

Query: 1261 IKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKK 1320
            IKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKK
Sbjct: 1261 IKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKK 1320

Query: 1321 QCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCK 1380
            QCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCK
Sbjct: 1321 QCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCK 1380

Query: 1381 DIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQ 1440
            DIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQ
Sbjct: 1381 DIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQ 1440

Query: 1441 RQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGV 1500
            RQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGV
Sbjct: 1441 RQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGV 1500

Query: 1501 TSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARES 1560
            TSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARES
Sbjct: 1501 TSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARES 1560

Query: 1561 SSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKA 1620
            SSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKA
Sbjct: 1561 SSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKA 1620

Query: 1621 RAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSED 1680
            RAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSED
Sbjct: 1621 RAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSED 1680

Query: 1681 EQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKS 1740
            EQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKS
Sbjct: 1681 EQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKS 1740

Query: 1741 HTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPGRSGG 1800
            HTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPGRSGG
Sbjct: 1741 HTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPGRSGG 1800

Query: 1801 RKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCS 1860
            RKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCS
Sbjct: 1801 RKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCS 1860

Query: 1861 SDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKA 1920
            SDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKA
Sbjct: 1861 SDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKA 1920

Query: 1921 RTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCE 1980
            RTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCE
Sbjct: 1921 RTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCE 1980

Query: 1981 GSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDA 2040
            GSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDA
Sbjct: 1981 GSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDA 2040

Query: 2041 PSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRR 2100
            PSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRR
Sbjct: 2041 PSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRR 2100

Query: 2101 LRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDL 2160
            LRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDL
Sbjct: 2101 LRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDL 2160

Query: 2161 GSVTESDIDCTDNTKTKRRKTKGKAKVVRKGKTFTANISKTVRRQRQSKRPRLSVDDNDW 2220
            GSVTESDIDCTDNTKTKRRKTKGKAKVVRKGKTFTANISKTVRRQRQSKRPRLSVDDNDW
Sbjct: 2161 GSVTESDIDCTDNTKTKRRKTKGKAKVVRKGKTFTANISKTVRRQRQSKRPRLSVDDNDW 2220

Query: 2221 EDLDYAKSKRVLRRSKIKTRNQGRRTVRYHDGDDDRSLENVLDFNGCTL 2269
            EDLDYAKSKRVLRRSKIKTRNQGRRTVRYHDGDDDRSLENVLDFNGCTL
Sbjct: 2221 EDLDYAKSKRVLRRSKIKTRNQGRRTVRYHDGDDDRSLENVLDFNGCTL 2269


>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
            [Homo sapiens]
          Length = 2320

 Score = 4424 bits (11473), Expect = 0.0
 Identities = 2190/2190 (100%), Positives = 2190/2190 (100%)

Query: 1    MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN 60
            MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN
Sbjct: 1    MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN 60

Query: 61   RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRH 120
            RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRH
Sbjct: 61   RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRH 120

Query: 121  TVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR 180
            TVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR
Sbjct: 121  TVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR 180

Query: 181  RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN 240
            RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN
Sbjct: 181  RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN 240

Query: 241  TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCF 300
            TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCF
Sbjct: 241  TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCF 300

Query: 301  WQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK 360
            WQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK
Sbjct: 301  WQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK 360

Query: 361  IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSE 420
            IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSE
Sbjct: 361  IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSE 420

Query: 421  EERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFD 480
            EERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFD
Sbjct: 421  EERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFD 480

Query: 481  SRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL 540
            SRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL
Sbjct: 481  SRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL 540

Query: 541  LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPH 600
            LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPH
Sbjct: 541  LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPH 600

Query: 601  PTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIR 660
            PTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIR
Sbjct: 601  PTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIR 660

Query: 661  QLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH 720
            QLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH
Sbjct: 661  QLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH 720

Query: 721  QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQL 780
            QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQL
Sbjct: 721  QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQL 780

Query: 781  SHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSS 840
            SHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSS
Sbjct: 781  SHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSS 840

Query: 841  EEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIS 900
            EEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIS
Sbjct: 841  EEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIS 900

Query: 901  TENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQ 960
            TENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQ
Sbjct: 901  TENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQ 960

Query: 961  MGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLC 1020
            MGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLC
Sbjct: 961  MGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLC 1020

Query: 1021 CLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDA 1080
            CLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDA
Sbjct: 1021 CLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDA 1080

Query: 1081 WWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISV 1140
            WWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISV
Sbjct: 1081 WWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISV 1140

Query: 1141 TTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTV 1200
            TTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTV
Sbjct: 1141 TTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTV 1200

Query: 1201 VAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKF 1260
            VAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKF
Sbjct: 1201 VAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKF 1260

Query: 1261 IKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKK 1320
            IKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKK
Sbjct: 1261 IKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKK 1320

Query: 1321 QCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCK 1380
            QCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCK
Sbjct: 1321 QCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCK 1380

Query: 1381 DIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQ 1440
            DIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQ
Sbjct: 1381 DIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQ 1440

Query: 1441 RQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGV 1500
            RQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGV
Sbjct: 1441 RQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGV 1500

Query: 1501 TSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARES 1560
            TSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARES
Sbjct: 1501 TSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARES 1560

Query: 1561 SSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKA 1620
            SSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKA
Sbjct: 1561 SSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKA 1620

Query: 1621 RAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSED 1680
            RAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSED
Sbjct: 1621 RAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSED 1680

Query: 1681 EQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKS 1740
            EQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKS
Sbjct: 1681 EQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKS 1740

Query: 1741 HTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPGRSGG 1800
            HTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPGRSGG
Sbjct: 1741 HTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPGRSGG 1800

Query: 1801 RKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCS 1860
            RKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCS
Sbjct: 1801 RKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCS 1860

Query: 1861 SDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKA 1920
            SDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKA
Sbjct: 1861 SDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKA 1920

Query: 1921 RTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCE 1980
            RTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCE
Sbjct: 1921 RTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCE 1980

Query: 1981 GSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDA 2040
            GSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDA
Sbjct: 1981 GSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDA 2040

Query: 2041 PSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRR 2100
            PSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRR
Sbjct: 2041 PSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRR 2100

Query: 2101 LRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDL 2160
            LRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDL
Sbjct: 2101 LRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDL 2160

Query: 2161 GSVTESDIDCTDNTKTKRRKTKGKAKVVRK 2190
            GSVTESDIDCTDNTKTKRRKTKGKAKVVRK
Sbjct: 2161 GSVTESDIDCTDNTKTKRRKTKGKAKVVRK 2190



 Score =  170 bits (430), Expect = 2e-41
 Identities = 189/670 (28%), Positives = 294/670 (43%), Gaps = 84/670 (12%)

Query: 1328 LIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFS 1387
            L+   ED +  +  ++  E  D   ++             ++ N DS  E   D+R+   
Sbjct: 1674 LLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESE--SDLRVARK 1731

Query: 1388 N--AKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQRQNCK 1445
            N  A  Y  +  +   +  L++ +  EE  K   SD                      C 
Sbjct: 1732 NWHANGYKSHTPAPSKTKFLKIESS-EEDSKSHDSDHA--------------------CN 1770

Query: 1446 GDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGVTSGDS 1505
              + P+ S++ LK + +  +    P   G    +T         HK ++         DS
Sbjct: 1771 RTAGPSTSVQKLKAESISEEADSEPGRSGGRKYNTF--------HKNASFFKKTKILSDS 1822

Query: 1506 SDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSSRSG 1565
             DS    E  +++R       +  + +  +L     + +  SS+   E+      S    
Sbjct: 1823 EDS----ESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCSSDHGCETDL---DSDDDK 1875

Query: 1566 LSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKARAGNN 1625
            + + +N                S  NG  RK +RKRV  SDSD++     +  KAR G  
Sbjct: 1876 IEKPNNFM----------KDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKARTGLL 1925

Query: 1626 RKVLRKCAAVAANKIKLMSDVE----ENSSSESVCSGRKLPHRNASAVARKKLLHNSEDE 1681
            R + R+CAA AANKIKLMSDVE    EN  + S  +GRK P   A   A+KKL   S+ E
Sbjct: 1926 R-ITRRCAATAANKIKLMSDVEDVSLENVHTRSK-NGRKKPLHLACTTAKKKL---SDCE 1980

Query: 1682 QSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKSH 1741
             S+  E+  E+   E +  P   S  +   + ++ N DS+SE  L    K+ H N +K  
Sbjct: 1981 GSVHCEVPSEQYACEGKP-PDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHK-- 2037

Query: 1742 TPAPSKTKFLKIESSEEDSKSHDSDHACNRT-AGPSTSVQKLKAESISE-EADSEPGRSG 1799
              APSK K   + SS EDSKSH      +RT +  ST  QK  AE+  E E +    R  
Sbjct: 2038 IDAPSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWN 2097

Query: 1800 GRKYNTFHKNASFFKKTKILSDSEDSESEE--QDREDGKCHKMEMNPISGNLNCDPIAMS 1857
            GR+  T+ K    F KTK++ DS+++  +E  + R   +   ++++  +GN    P   S
Sbjct: 2098 GRRLRTYGKAP--FSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSS 2155

Query: 1858 QCSSDHGC--ETDLDSDDDKIEKPNN-------FMKDSASQDNGLSRKISRKRVCSSDSD 1908
            + SSD G   E+D+D  D+   K            K+   +D   + K+   R C  +  
Sbjct: 2156 K-SSDLGSVTESDIDCTDNTKTKRRKTKGKAKVVRKEFVPRDREPNTKV---RTCMHNQK 2211

Query: 1909 SSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDV--SLENVHTRSKNGRKKPLH 1966
             ++Q+  ++ KA+    ++ RRCA  AANKIK+MS++++     ENV  R K+ RK P  
Sbjct: 2212 DAVQMPSETLKAKMVPEKVPRRCATVAANKIKIMSNLKETISGPENVWIR-KSSRKLPHR 2270

Query: 1967 LACTTAKKKL 1976
             A   AKKKL
Sbjct: 2271 NASAAAKKKL 2280



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 66/200 (33%), Positives = 98/200 (49%), Gaps = 17/200 (8%)

Query: 1504 DSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSSR 1563
            DS ++AE   +RKR+ P      +SE+          SS +S     ++      +++  
Sbjct: 2117 DSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTDNTKT 2176

Query: 1564 SGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKARAG 1623
                     +V R     R   P           T+ R  + +  +      E LKA+  
Sbjct: 2177 KRRKTKGKAKVVRKEFVPRDREP----------NTKVRTCMHNQKDAVQMPSETLKAKMV 2226

Query: 1624 NNRKVLRKCAAVAANKIKLMSDVEEN-SSSESVC---SGRKLPHRNASAVARKKLLH-NS 1678
               KV R+CA VAANKIK+MS+++E  S  E+V    S RKLPHRNASA A+KKLL+   
Sbjct: 2227 PE-KVPRRCATVAANKIKIMSNLKETISGPENVWIRKSSRKLPHRNASAAAKKKLLNVYK 2285

Query: 1679 EDEQSLKSEIEEEELKDENQ 1698
            ED+ ++ SE  E+EL+D N+
Sbjct: 2286 EDDTTINSE-SEKELEDINR 2304


>gi|153791630 bromodomain and WD repeat domain containing 3 [Homo
            sapiens]
          Length = 1802

 Score = 1882 bits (4875), Expect = 0.0
 Identities = 966/1653 (58%), Positives = 1187/1653 (71%), Gaps = 101/1653 (6%)

Query: 14   IESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHV 73
            IE+ELY+LIAR+L +GPC ++AQVLVQELE++QL+P+RLDWEG EH RS+E+LV +N H+
Sbjct: 8    IEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANAHI 67

Query: 74   APDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHR 133
             PD+LL+IC+RIGP+LDKEIP S+  V +LLG GRQSLLR AKDC+ T+W GSAFAALHR
Sbjct: 68   PPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHR 127

Query: 134  GRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVA 193
            GRPPE+PVNY  PPN+V I   +QLTGCS F   FP + YQHIKMH+RILGHLS+VYCVA
Sbjct: 128  GRPPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHLSSVYCVA 187

Query: 194  FDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIR 253
            FDR+G RIFTGSDDCLVKIW+T +GRLL+TLRGHSAEISDMAVNYENT+IAAGSCDK++R
Sbjct: 188  FDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVR 247

Query: 254  VWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPR 313
            VWCLRTCAPVAVLQGH+ SITS+QF P  KG+ RY+ STGADGT+CFWQW ++++KF  R
Sbjct: 248  VWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDR 307

Query: 314  PLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDS 373
            P+KFTE+ RPGVQ+ CSSFS GGMF+ TGSTDHVIR+Y+LG E PEKIAELESHTDKV +
Sbjct: 308  PVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVA 367

Query: 374  IQFCNNGD--RFLSGSRDGTARIWRFEQLEWRSILLDMATRISG-DLSSEEERFMKPKVT 430
            +QFCNNGD  RF+SGSRDGTARIW+++Q EW+SI+LDMAT+++G +L S E++  K KVT
Sbjct: 368  VQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVT 427

Query: 431  MIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHD 490
            M+AW++ D+ V+TAVN+ +LKVWNS TGQLLH L GH DEVFVLE HPFD RI+LSAGHD
Sbjct: 428  MVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHD 487

Query: 491  GSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKP 550
            G+IFIWD+ +GTK+++YFNMIEGQGHGAVFDCKFS DG HFACTDSHGHLL+FGFGCSK 
Sbjct: 488  GNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKY 547

Query: 551  YEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKYQRLVPG 610
            YEKIPDQMFFHTDYRPLIRD+NNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTK+QRLVPG
Sbjct: 548  YEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPG 607

Query: 611  RENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRM 670
            REN  DE LIPQLGYVA  DGEV+EQ+I  QTND DE     SILDG+IR+LQ++QD R+
Sbjct: 608  RENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDE-----SILDGIIRELQREQDLRL 662

Query: 671  GADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRR-SGQVEGVRQMHQNAPRSQIA 729
              ++  +P    N   +     R  ++DI S PNI LRR S Q+EGVRQMH NAPRSQ+A
Sbjct: 663  -INEGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMA 721

Query: 730  TERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQLSHKSDSVVL 789
            TERDL AW RRVVV E+  G+ R  E+ R  KG+ E +LY + +K+K    + ++D    
Sbjct: 722  TERDLMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPS 781

Query: 790  VSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSSEEDE--WRS 847
              +S +RT R++   Y  R        S  E +S    + S  Q +   SSEEDE    S
Sbjct: 782  CGRSLRRTQRKRQHTYQTR--------SNIEHNSQASCQNSGVQEDSDSSSEEDETVGTS 833

Query: 848  DRKSE------SYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIST 901
            D   E          SSSDSSS YSDWTADAGINLQPP R + R+   + CSSS++    
Sbjct: 834  DASVEDPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQT-RQTTRKICSSSDE---- 888

Query: 902  ENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQM 961
            ENL   + R+K+ K+ + KK  L  +        E   E+  P WI DT  R+SPFVPQM
Sbjct: 889  ENLKSLEERQKKPKQTRKKKGGLVSIAG------EPNEEWFAPQWILDTIPRRSPFVPQM 942

Query: 962  GDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLCC 1021
            GDE+IYFRQGHEAY+ AVR++ IY +N  K+PW KMDLR+QE VKIVGI+YEVGPPTLCC
Sbjct: 943  GDELIYFRQGHEAYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCC 1002

Query: 1022 LKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDAW 1081
            LKLAF+DP +GK+  +SFSI+YHDMPDVIDFLVL QFY+EA++RNWQ  DRFRSIIDDAW
Sbjct: 1003 LKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAW 1062

Query: 1082 WFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISVT 1141
            WFGTV SQ+P+QP+YPDS FQCY V WDN E EK+SPWDMEPIP+    P+E+GA + V+
Sbjct: 1063 WFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVS 1122

Query: 1142 TDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVV 1201
             +EL  LLYKPQ GEWG  SRDEEC+R+I GI+ LL+LD A+ FA PVDL  YP YCTVV
Sbjct: 1123 QEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVV 1182

Query: 1202 AYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFI 1261
            AYPTDL TIR RL NRFYRR+SAL+WEVRYIEHNARTFNEP+S I ++AK +TD LL+FI
Sbjct: 1183 AYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFI 1242

Query: 1262 KNQHCTNISELSNTSENDEQNAEDLD--------DSDLPKTSSGRRRVHDGKKSIRATNY 1313
             +Q CT+I +  N  + +E+N+ D +        DSD P TSSGR+    G++     N 
Sbjct: 1243 GDQSCTDILDTYNKIKAEERNSTDAEEDTEIVDLDSDGPGTSSGRKVKCRGRRQSLKCN- 1301

Query: 1314 VESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYP------------------------- 1348
                WKKQCKEL++LI++ EDSEPFRQP DL+ YP                         
Sbjct: 1302 -PDAWKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSE 1360

Query: 1349 DYRDIIDTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLS 1408
            DY+D+IDTP+DF TV+ETL+AGNY SPLEF KD+R IF+N+KAYT NK+S+IYSM LRLS
Sbjct: 1361 DYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLS 1420

Query: 1409 ALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQRQNCKGDSQPNKSIRNLKPKRLKSQ--- 1465
            ALFE  +K I S++K   +  ++ R   R + R +    S         K K++K Q   
Sbjct: 1421 ALFESHIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKN 1480

Query: 1466 ---TKIIPELVGSPTQSTSSRTA-----YLGTHKTSAGISSG-----VTSGDSSDSAESS 1512
               T +      SP  S  S  A     YL   +     SS        SG+S D  ++ 
Sbjct: 1481 DQNTSVSHARTSSPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAK 1540

Query: 1513 ERRKR----------NRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSS 1562
              R R          + P+TNG      E    +   L S++        E    +E+  
Sbjct: 1541 SFRNRVLPVKQDHSLDGPLTNG---DGREPRTGIKRKLLSASEEDENMGGEDKEKKETKE 1597

Query: 1563 RSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGR 1595
            +S LS S +  +  + +++   G  S +    R
Sbjct: 1598 KSHLSTSESGELGSSLSSESTCGSDSDSESTSR 1630



 Score = 39.7 bits (91), Expect = 0.034
 Identities = 24/61 (39%), Positives = 34/61 (55%), Gaps = 5/61 (8%)

Query: 2203 RRQRQSKRPRLSVDDNDWEDLDYAKSKRVLRRSKIKTRNQGRRTVRYHDGDDDRSLENVL 2262
            R   ++KR R++ D+      D   S R  R  +IKTRNQGRRTV Y+D  D+ +  +  
Sbjct: 1718 RGATRAKRARIADDE-----FDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTE 1772

Query: 2263 D 2263
            D
Sbjct: 1773 D 1773



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 46/237 (19%), Positives = 95/237 (40%), Gaps = 21/237 (8%)

Query: 1540 LSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATR 1599
            L SS+SS S     S + ++   +       N  V+  R +   + PVS A      A  
Sbjct: 1452 LRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTSSPFSSPVSDA------AEG 1505

Query: 1600 KRVYLSDSDNNSLETGEILK--ARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCS 1657
              +YL D + +   +       +R+GN+           + + +++   +++S    + +
Sbjct: 1506 LSLYLLDDEPDGPFSSSSFGGYSRSGNSHDP----GKAKSFRNRVLPVKQDHSLDGPLTN 1561

Query: 1658 GRKLPHRNASAVARKKLLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESEN 1717
            G     R      ++KLL  SE+++++  E +E++   E   L  S S    S++     
Sbjct: 1562 G---DGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELGSSLSSEST 1618

Query: 1718 RDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAG 1774
              S+S+S+        + +G   +      +KF++     +  K H +     +T G
Sbjct: 1619 CGSDSDSESTSRTDQDYVDGDHDY------SKFIQTRPKRKLRKQHGNGKRNWKTRG 1669



 Score = 32.3 bits (72), Expect = 5.4
 Identities = 20/73 (27%), Positives = 37/73 (50%), Gaps = 3/73 (4%)

Query: 1815 KTKILSDSEDSES---EEQDREDGKCHKMEMNPISGNLNCDPIAMSQCSSDHGCETDLDS 1871
            K K+LS SE+ E+   E++++++ K         SG L     + S C SD   E+   +
Sbjct: 1572 KRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELGSSLSSESTCGSDSDSESTSRT 1631

Query: 1872 DDDKIEKPNNFMK 1884
            D D ++  +++ K
Sbjct: 1632 DQDYVDGDHDYSK 1644


>gi|34996489 pleckstrin homology domain interacting protein [Homo
            sapiens]
          Length = 1821

 Score = 1826 bits (4729), Expect = 0.0
 Identities = 941/1676 (56%), Positives = 1172/1676 (69%), Gaps = 89/1676 (5%)

Query: 5    SSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYE 64
            S  R+ +  + SELYFLIAR+L  GPC++AAQVL++E+ + +LLP+R DW G EH R+Y+
Sbjct: 2    SCERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQ 61

Query: 65   ELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWK 124
             LV   +H+APDHLLQIC R+GP+L++EIP S+  V +LLGAGRQSLLRT K C+H VWK
Sbjct: 62   NLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWK 121

Query: 125  GSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILG 184
            GSA AALH GRPPE PVNYGSPP++ +    ++L G        P  +YQH+KMH+RILG
Sbjct: 122  GSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILG 181

Query: 185  HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
            HLS+VYCV FDRTG RIFTGSDDCLVKIW+T +GRLL+TLRGH+AEISDMAVNYENTMIA
Sbjct: 182  HLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIA 241

Query: 245  AGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWD 304
            AGSCDK+IRVWCLRTCAP+AVLQGH+ SITSLQFSP+  GS+RY+ STGADGT+CFW WD
Sbjct: 242  AGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWD 301

Query: 305  LESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAEL 364
              +LK +PRP KFTE+PRPGVQM+CSSFS GGMFLATGSTDH+IR+YF G   PEKI+EL
Sbjct: 302  AGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISEL 361

Query: 365  ESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISG-DLSSEEER 423
            E HTDKVDSIQF N  +RF+SGSRDGTARIW+F++ EW+SILLDMATR +G +L   E++
Sbjct: 362  EFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDK 421

Query: 424  FMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRI 483
              K KVTM+AW+++D+ V+TAVN+  LKVWNSYTGQL+H LMGH DEVFVLE HPFD R+
Sbjct: 422  ITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRV 481

Query: 484  MLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIF 543
            + SAGHDG++ +WD+ +G K++ YFNMIEGQGHGAVFDCK S DGQHFACTDSHGHLLIF
Sbjct: 482  LFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIF 541

Query: 544  GFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTK 603
            GFG S  Y+KI DQMFFH+DYRPLIRD+NN+VLDEQTQQAPHLMPPPFLVDVDGNPHP++
Sbjct: 542  GFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSR 601

Query: 604  YQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQ 663
            YQRLVPGREN  +E LIPQ+G   TS G  + Q++S Q N       E S LD MI++LQ
Sbjct: 602  YQRLVPGRENCREEQLIPQMG--VTSSG--LNQVLSQQANQ------EISPLDSMIQRLQ 651

Query: 664  QQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNA 723
            Q+QD R   +      G+SN     R      S ++ SPPN+GLRRSGQ+EGVRQMH NA
Sbjct: 652  QEQDLRRSGE-----AGISNTSRLSRGSISSTS-EVHSPPNVGLRRSGQIEGVRQMHSNA 705

Query: 724  PRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQLSHK 783
            PRS+IATERDL AW RRVVVPE+  G+  + E++R  KGEEE   Y    KRK L +  K
Sbjct: 706  PRSEIATERDLVAWSRRVVVPELSAGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVP-K 764

Query: 784  SDSVVLVSQS-------------RQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETS 830
             + +  VS++             +Q+T +  Y        + R        SSS      
Sbjct: 765  ENKIPTVSKNHAHEHFLDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGEV 824

Query: 831  CDQSEGSGSSEEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITR 890
               S G+   EE  W SD        SSSD SS YSDWTADAGINLQPP +    +    
Sbjct: 825  VAVSGGTSEEEERAWHSD-------GSSSDYSSDYSDWTADAGINLQPPKKVPKNKTKKA 877

Query: 891  FCSSSEDEISTENLSPPKRRRKRK-----------KENKPKKENLRRMTPAELA-NMEHL 938
              SS E+E S +      ++ K+K           K+ KPK+   +R+   EL  N   L
Sbjct: 878  ESSSDEEEESEKQKQKQIKKEKKKVNEEKDGPISPKKKKPKERKQKRLAVGELTENGLTL 937

Query: 939  YEFHPPVWITDTTLRKSPFVPQMGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMD 998
             E+ P  WITDT  R+ PFVPQMGDEV YFRQGHEAY+E  R+N IY +NP K+PW KM+
Sbjct: 938  EEWLPSTWITDTIPRRCPFVPQMGDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKME 997

Query: 999  LRDQELVKIVGIRYEVGPPTLCCLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQF 1058
            LR+QEL+KIVGI+YEVG PTLCCLKLAF+DP TGKL   SF+++YHDMPDVIDFLVLRQ 
Sbjct: 998  LREQELMKIVGIKYEVGLPTLCCLKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQ 1057

Query: 1059 YDEARQRNWQSCDRFRSIIDDAWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSP 1118
            +D+A+ R W   DRFRS+IDDAWWFGT+ SQEP Q +YPDS FQCY V WDN + EK+SP
Sbjct: 1058 FDDAKYRRWNIGDRFRSVIDDAWWFGTIESQEPLQLEYPDSLFQCYNVCWDNGDTEKMSP 1117

Query: 1119 WDMEPIPDNVDPPEELGASISVTTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLN 1178
            WDME IP+N   PEELG S+ +T  E   L+YKP  GEWG   RDEEC+RI++GI+QL+ 
Sbjct: 1118 WDMELIPNNAVFPEELGTSVPLTDGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMT 1177

Query: 1179 LDIAAAFAGPVDLCTYPKYCTVVAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNART 1238
            LDIA+AF  PVDL  YP YCTVVAYPTDL TI+ RL NRFYRR+S+L+WEVRYIEHN RT
Sbjct: 1178 LDIASAFVAPVDLQAYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRT 1237

Query: 1239 FNEPESVIARSAKKITDQLLKFIKNQHCTNISELSNTSEND--EQNAEDLDDSDLPKTSS 1296
            FNEP S I +SAK +TD LL FIK+Q C NI  L N+ +      + ++  D+D+P TS+
Sbjct: 1238 FNEPGSPIVKSAKFVTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDSEDEEKDADVPGTST 1297

Query: 1297 GRRRVHDGKKSI--RATNYVESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDII 1354
             +R+ H  ++ +  RA +Y    WKKQC+EL+NLIFQCEDSEPFRQPVDL+EYPDYRDII
Sbjct: 1298 RKRKDHQPRRRLRNRAQSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDII 1357

Query: 1355 DTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEK 1414
            DTPMDF TVRETL+AGNY+SP+E CKD+RLIFSN+KAYTP+KRS+IYSM+LRLSA FEE 
Sbjct: 1358 DTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEH 1417

Query: 1415 MKKISSDFKIGQKFNEKLRRSQRFKQRQ-----NCKGDSQPNKSIRNLKPKRLKSQTKII 1469
            +  + SD+K   +F+++   ++R K+R      +    S P +  R LKP +LKS++   
Sbjct: 1418 ISSVLSDYKSALRFHKRNTITKRRKKRNRSSSVSSSAASSPERKKRILKP-QLKSESS-- 1474

Query: 1470 PELVGSPTQSTSSR------------TAYLGTHKTSAGISSGVTSGDSSDSAESSERRKR 1517
                 +PT+S   R            ++ + T      +   VT   S+ SA  +   K 
Sbjct: 1475 TSAFSTPTRSIPPRHNAAQINGKTESSSVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKA 1534

Query: 1518 NRPITNGSTLSESEVEDSLA-TSLSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTR 1576
            N     G T+ E+ V+ S A  +LSS   SS      ++ A+E+             + +
Sbjct: 1535 NASAIPGKTILENSVKHSKALNTLSSPGQSSFSHGTRNNSAKEN-------------MEK 1581

Query: 1577 TRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEI-LKARAGNNRKVLRK 1631
             +  +RK     L        +   +   D  NN+L  G I +    G   K++++
Sbjct: 1582 EKPVKRKMKSSVLPKASTLSKSSAVIEQGDCKNNALVPGTIQVNGHGGQPSKLVKR 1637



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 64/276 (23%), Positives = 112/276 (40%), Gaps = 28/276 (10%)

Query: 1993 ACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDAPSKRKSSSVTSS 2052
            A  GK    +S   +K L+  L+    S     + +     N+ K + P KRK  S    
Sbjct: 1538 AIPGKTILENSVKHSKALN-TLSSPGQSSFSHGTRNNSAKENMEK-EKPVKRKMKS---- 1591

Query: 2053 GEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKT 2112
                 S +P + T    S  S + ++   +NN  V     +    G+  +   + P  K 
Sbjct: 1592 -----SVLPKAST---LSKSSAVIEQGDCKNNALVPGTIQVNGHGGQPSKLVKRGPGRKP 1643

Query: 2113 KVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTD 2172
            KV  ++        KR R   +L+  K  +   N+        +   L S T + +  T+
Sbjct: 1644 KVEVNTNSGEIIHKKRGRKPKKLQYAKPEDLEQNNVH----PIRDEVLPSSTCNFLSETN 1699

Query: 2173 NTKTK--RRKTKGKAKVVRKGKTFTAN----ISKTVRRQRQSKRPRLSVDDNDWEDLDYA 2226
            N K    ++K +G  K  RK KT   +    +  +V+  R+S R ++    ++ E+ +  
Sbjct: 1700 NVKEDLLQKKNRGGRKPKRKMKTQKLDADLLVPASVKVLRRSNRKKIDDPIDEEEEFEEL 1759

Query: 2227 KSKRVLRRSKIKTRNQGRRTVRYHDGDDDRSLENVL 2262
            K         ++TRNQGRRT  Y++ D +     +L
Sbjct: 1760 KGSE----PHMRTRNQGRRTAFYNEDDSEEEQRQLL 1791



 Score = 32.7 bits (73), Expect = 4.2
 Identities = 31/159 (19%), Positives = 69/159 (43%), Gaps = 17/159 (10%)

Query: 2019 DSEDMLNSEHKHR-HTNIHKIDAPSKRKSSSVTSSGEDSKSHIPGS---ETDRTFSSEST 2074
            +S+    ++H +R  + + +   PS+   +  +SS E     + G    E +R + S+ +
Sbjct: 785  ESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGEVVAVSGGTSEEEERAWHSDGS 844

Query: 2075 LAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPE 2134
             +  ++  +++  +         G  L+   K P +KTK    S +  E+  K+K+   +
Sbjct: 845  SSDYSSDYSDWTADA--------GINLQPPKKVPKNKTKKAESSSDEEEESEKQKQKQIK 896

Query: 2135 LENVKISE-----TTGNSKFRPDTSSKSSDLGSVTESDI 2168
             E  K++E      +   K   +   K   +G +TE+ +
Sbjct: 897  KEKKKVNEEKDGPISPKKKKPKERKQKRLAVGELTENGL 935


>gi|55956930 bromodomain and WD repeat domain containing 1 isoform C
           [Homo sapiens]
          Length = 120

 Score =  232 bits (592), Expect = 3e-60
 Identities = 116/116 (100%), Positives = 116/116 (100%)

Query: 1   MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN 60
           MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN
Sbjct: 1   MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHN 60

Query: 61  RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAK 116
           RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAK
Sbjct: 61  RSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAK 116


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  116 bits (291), Expect = 2e-25
 Identities = 88/315 (27%), Positives = 145/315 (46%), Gaps = 34/315 (10%)

Query: 184 GHLSAVYCVAFDRT-GHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTM 242
           GH + VY +AF+   G +I TGS D   K+WS   G+   T RGH+AEI  ++ N ++T+
Sbjct: 132 GHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTL 191

Query: 243 IAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQ 302
           +A GS D   ++W ++    V  L+GH+  I SL F+     S   +++   D TV  W 
Sbjct: 192 VATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNT----SGDRIITGSFDHTVVVWD 247

Query: 303 WDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIA 362
            D           K         ++  +SF+     + TGS D   +++       + +A
Sbjct: 248 ADTGR--------KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW--DATNGKCVA 297

Query: 363 ELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATR-ISGDLSSEE 421
            L  H D++    F   G    + S DGTARI+              ATR     L   E
Sbjct: 298 TLTGHDDEILDSCFDYTGKLIATASADGTARIF------------SAATRKCIAKLEGHE 345

Query: 422 ERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDS 481
                 +++ I++N   + ++T  +D   ++W++ TGQ L  L GH DE+F    + +  
Sbjct: 346 -----GEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN-YKG 399

Query: 482 RIMLSAGHDGSIFIW 496
            I+++   D +  IW
Sbjct: 400 NIVITGSKDNTCRIW 414



 Score =  105 bits (263), Expect = 4e-22
 Identities = 78/277 (28%), Positives = 118/277 (42%), Gaps = 30/277 (10%)

Query: 177 KMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAV 236
           K +    GH + + C++F+     + TGS D   K+W   NG  + TLRGHSAEI  ++ 
Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227

Query: 237 NYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADG 296
           N     I  GS D  + VW   T   V +L GH   I+S  F+         ++ TG+  
Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS-----LILTGSMD 282

Query: 297 TVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFE 356
             C   WD  + K         +      ++L S F   G  +AT S D   R++     
Sbjct: 283 KTC-KLWDATNGKCVATLTGHDD------EILDSCFDYTGKLIATASADGTARIF--SAA 333

Query: 357 APEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGD 416
             + IA+LE H  ++  I F   G+  L+GS D TARIW  +  +   +L      I   
Sbjct: 334 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFS- 392

Query: 417 LSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVW 453
                           A+N   +IV+T   D+  ++W
Sbjct: 393 ---------------CAFNYKGNIVITGSKDNTCRIW 414



 Score = 99.4 bits (246), Expect = 4e-20
 Identities = 69/214 (32%), Positives = 101/214 (47%), Gaps = 16/214 (7%)

Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMI 243
           GH + +  ++F+ +G RI TGS D  V +W    GR ++ L GH AEIS  + N++ ++I
Sbjct: 217 GHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLI 276

Query: 244 AAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQW 303
             GS DK  ++W       VA L GH   I    F    K     + +  ADGT      
Sbjct: 277 LTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK----LIATASADGTARI--- 329

Query: 304 DLESLKFSPRPLKFTEKPRPGVQMLCS-SFSVGGMFLATGSTDHVIRMYFLGFEAPEKIA 362
                 FS    K   K       +   SF+  G  L TGS+D   R++    +  + + 
Sbjct: 330 ------FSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW--DAQTGQCLQ 381

Query: 363 ELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWR 396
            LE HTD++ S  F   G+  ++GS+D T RIWR
Sbjct: 382 VLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415



 Score = 84.7 bits (208), Expect = 9e-16
 Identities = 69/317 (21%), Positives = 137/317 (43%), Gaps = 35/317 (11%)

Query: 214 STHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSI 273
           S H   L   L+ H   ++++A+N   +    GS D+  ++W   +   +  L+GH   +
Sbjct: 78  SNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVV 137

Query: 274 TSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFS 333
            ++ F+          ++TG+    C   W +E+ K        T       +++C SF+
Sbjct: 138 YAIAFN----NPYGDKIATGSFDKTC-KLWSVETGKCYHTFRGHT------AEIVCLSFN 186

Query: 334 VGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTAR 393
                +ATGS D   +++    +  E++  L  H+ ++ S+ F  +GDR ++GS D T  
Sbjct: 187 PQSTLVATGSMDTTAKLW--DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVV 244

Query: 394 IWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVW 453
           +W  +     +IL+     IS                  ++N + S+++T   D   K+W
Sbjct: 245 VWDADTGRKVNILIGHCAEISS----------------ASFNWDCSLILTGSMDKTCKLW 288

Query: 454 NSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEG 513
           ++  G+ +  L GH DE+ +     +  +++ +A  DG+  I+        +     +EG
Sbjct: 289 DATNGKCVATLTGHDDEI-LDSCFDYTGKLIATASADGTARIF----SAATRKCIAKLEG 343

Query: 514 QGHGAVFDCKFSQDGQH 530
              G +    F+  G H
Sbjct: 344 H-EGEISKISFNPQGNH 359


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  103 bits (258), Expect = 1e-21
 Identities = 113/487 (23%), Positives = 207/487 (42%), Gaps = 67/487 (13%)

Query: 54  WEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAG---RQS 110
           W G E   + +EL+ S +     H++Q+   I P   ++    + +  +L        + 
Sbjct: 126 WSGPEKLLALDELIDSCEPTQVKHMMQV---IEPQFQRDFISLLPKELALYVLSFLEPKD 182

Query: 111 LLRTAKDCRHTVWKGSAFA-ALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFP 169
           LL+ A+ CR+  W+  A    L R +  E  ++       + I R K +      S    
Sbjct: 183 LLQAAQTCRY--WRILAEDNLLWREKCKEEGID-----EPLHIKRRKVIKPGFIHSPWKS 235

Query: 170 GTMYQH----------IKMHRRILGHLSAVY-CVAFDRTGHRIFTGSDDCLVKIWSTHNG 218
             + QH          +K  + + GH   V  C+ F   G+RI +GSDD  +K+WS   G
Sbjct: 236 AYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTG 293

Query: 219 RLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQF 278
           + L TL GH+  +   +    + +I +GS D+ ++VW   T   +  L GHT ++  +  
Sbjct: 294 KCLRTLVGHTGGV--WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 351

Query: 279 SPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMF 338
                  ++ +VS   D T+  W  D+E+ +     +      R      C  +   G  
Sbjct: 352 H------EKRVVSGSRDATLRVW--DIETGQCLHVLMGHVAAVR------CVQYD--GRR 395

Query: 339 LATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFE 398
           + +G+ D +++++    E    +  L+ HT++V S+QF  +G   +SGS D + R+W  E
Sbjct: 396 VVSGAYDFMVKVW--DPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVE 451

Query: 399 QLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTG 458
                  L    +  SG                      D+I+V+   D  +K+W+  TG
Sbjct: 452 TGNCIHTLTGHQSLTSG------------------MELKDNILVSGNADSTVKIWDIKTG 493

Query: 459 QLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGA 518
           Q L  L G       +    F+   ++++  DG++ +WD+  G  +++   +  G   G 
Sbjct: 494 QCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 553

Query: 519 VFDCKFS 525
           V+  + S
Sbjct: 554 VWRIRAS 560


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  103 bits (258), Expect = 1e-21
 Identities = 113/487 (23%), Positives = 207/487 (42%), Gaps = 67/487 (13%)

Query: 54  WEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAG---RQS 110
           W G E   + +EL+ S +     H++Q+   I P   ++    + +  +L        + 
Sbjct: 244 WSGPEKLLALDELIDSCEPTQVKHMMQV---IEPQFQRDFISLLPKELALYVLSFLEPKD 300

Query: 111 LLRTAKDCRHTVWKGSAFA-ALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFP 169
           LL+ A+ CR+  W+  A    L R +  E  ++       + I R K +      S    
Sbjct: 301 LLQAAQTCRY--WRILAEDNLLWREKCKEEGID-----EPLHIKRRKVIKPGFIHSPWKS 353

Query: 170 GTMYQH----------IKMHRRILGHLSAVY-CVAFDRTGHRIFTGSDDCLVKIWSTHNG 218
             + QH          +K  + + GH   V  C+ F   G+RI +GSDD  +K+WS   G
Sbjct: 354 AYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTG 411

Query: 219 RLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQF 278
           + L TL GH+  +   +    + +I +GS D+ ++VW   T   +  L GHT ++  +  
Sbjct: 412 KCLRTLVGHTGGV--WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 469

Query: 279 SPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMF 338
                  ++ +VS   D T+  W  D+E+ +     +      R      C  +   G  
Sbjct: 470 H------EKRVVSGSRDATLRVW--DIETGQCLHVLMGHVAAVR------CVQYD--GRR 513

Query: 339 LATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFE 398
           + +G+ D +++++    E    +  L+ HT++V S+QF  +G   +SGS D + R+W  E
Sbjct: 514 VVSGAYDFMVKVW--DPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVE 569

Query: 399 QLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTG 458
                  L    +  SG                      D+I+V+   D  +K+W+  TG
Sbjct: 570 TGNCIHTLTGHQSLTSG------------------MELKDNILVSGNADSTVKIWDIKTG 611

Query: 459 QLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGA 518
           Q L  L G       +    F+   ++++  DG++ +WD+  G  +++   +  G   G 
Sbjct: 612 QCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 671

Query: 519 VFDCKFS 525
           V+  + S
Sbjct: 672 VWRIRAS 678


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  103 bits (258), Expect = 1e-21
 Identities = 113/487 (23%), Positives = 207/487 (42%), Gaps = 67/487 (13%)

Query: 54  WEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAG---RQS 110
           W G E   + +EL+ S +     H++Q+   I P   ++    + +  +L        + 
Sbjct: 164 WSGPEKLLALDELIDSCEPTQVKHMMQV---IEPQFQRDFISLLPKELALYVLSFLEPKD 220

Query: 111 LLRTAKDCRHTVWKGSAFA-ALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFP 169
           LL+ A+ CR+  W+  A    L R +  E  ++       + I R K +      S    
Sbjct: 221 LLQAAQTCRY--WRILAEDNLLWREKCKEEGID-----EPLHIKRRKVIKPGFIHSPWKS 273

Query: 170 GTMYQH----------IKMHRRILGHLSAVY-CVAFDRTGHRIFTGSDDCLVKIWSTHNG 218
             + QH          +K  + + GH   V  C+ F   G+RI +GSDD  +K+WS   G
Sbjct: 274 AYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTG 331

Query: 219 RLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQF 278
           + L TL GH+  +   +    + +I +GS D+ ++VW   T   +  L GHT ++  +  
Sbjct: 332 KCLRTLVGHTGGV--WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 389

Query: 279 SPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMF 338
                  ++ +VS   D T+  W  D+E+ +     +      R      C  +   G  
Sbjct: 390 H------EKRVVSGSRDATLRVW--DIETGQCLHVLMGHVAAVR------CVQYD--GRR 433

Query: 339 LATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFE 398
           + +G+ D +++++    E    +  L+ HT++V S+QF  +G   +SGS D + R+W  E
Sbjct: 434 VVSGAYDFMVKVW--DPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVE 489

Query: 399 QLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTG 458
                  L    +  SG                      D+I+V+   D  +K+W+  TG
Sbjct: 490 TGNCIHTLTGHQSLTSG------------------MELKDNILVSGNADSTVKIWDIKTG 531

Query: 459 QLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGA 518
           Q L  L G       +    F+   ++++  DG++ +WD+  G  +++   +  G   G 
Sbjct: 532 QCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 591

Query: 519 VFDCKFS 525
           V+  + S
Sbjct: 592 VWRIRAS 598


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score =  103 bits (258), Expect = 1e-21
 Identities = 80/317 (25%), Positives = 148/317 (46%), Gaps = 26/317 (8%)

Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNG-RLLSTLRGHSAEISDMAVNYENTM 242
           GH   VYC  F   G  + +   D L+ +W+ +      +TL+GHS  + ++  N + +M
Sbjct: 64  GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123

Query: 243 IAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGA-DGTVCFW 301
           + + S DK + VW   T   V  L+GHT  + S    P  +G Q  +V TG+ DGTV   
Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCY--PARRGPQ--LVCTGSDDGTVKL- 178

Query: 302 QWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKI 361
            WD+   K + +  + T       Q+L  +F+     + +G  D+ I+++ L     +  
Sbjct: 179 -WDIRK-KAAIQTFQNT------YQVLAVTFNDTSDQIISGGIDNDIKVWDL--RQNKLT 228

Query: 362 AELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEE 421
             +  H D V  +   + G   LS + D T R+W       +   + +     G++ + E
Sbjct: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKI---FQGNVHNFE 285

Query: 422 ERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDS 481
           +  ++      +W+ + S +     D  + VW++ + ++L+ L GHA  +  +  HP D 
Sbjct: 286 KNLLR-----CSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP-DE 339

Query: 482 RIMLSAGHDGSIFIWDI 498
            I++SA  D  +++ +I
Sbjct: 340 PIIISASSDKRLYMGEI 356



 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 71/328 (21%), Positives = 134/328 (40%), Gaps = 41/328 (12%)

Query: 256 CLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPL 315
           C    AP+ +L GH G +   +F P   GS   + S G D  +  W    +   ++    
Sbjct: 52  CSSLQAPIMLLSGHEGEVYCCKFHP--NGST--LASAGFDRLILLWNVYGDCDNYA---- 103

Query: 316 KFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQ 375
             T K   G  M    ++  G  L + STD  + ++    E  E++  L+ HT  V+S  
Sbjct: 104 --TLKGHSGAVMEL-HYNTDGSMLFSASTDKTVAVW--DSETGERVKRLKGHTSFVNSCY 158

Query: 376 FCNNGDRFL-SGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAW 434
               G + + +GS DGT ++W                R    + + +  +   +V  + +
Sbjct: 159 PARRGPQLVCTGSDDGTVKLWDI--------------RKKAAIQTFQNTY---QVLAVTF 201

Query: 435 NQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIF 494
           N     +++   D+ +KVW+    +L + + GHAD V  L     +   +LS   D ++ 
Sbjct: 202 NDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSS-EGSYLLSNAMDNTVR 260

Query: 495 IWDITKGTKMKHYFNMIEGQGHG---AVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPY 551
           +WD+      +    + +G  H     +  C +S DG   A   +   + ++     +  
Sbjct: 261 VWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL 320

Query: 552 EKIP------DQMFFHTDYRPLIRDSNN 573
            K+P      +++ FH D   +I  S++
Sbjct: 321 YKLPGHAGSINEVAFHPDEPIIISASSD 348



 Score = 58.5 bits (140), Expect = 7e-08
 Identities = 58/262 (22%), Positives = 102/262 (38%), Gaps = 52/262 (19%)

Query: 172 MYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEI 231
           +Y     +  + GH  AV  + ++  G  +F+ S D  V +W +  G  +  L+GH++ +
Sbjct: 95  VYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFV 154

Query: 232 SD----------------------------------------MAVNYENT--MIAAGSCD 249
           +                                         +AV + +T   I +G  D
Sbjct: 155 NSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGID 214

Query: 250 KIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLK 309
             I+VW LR       ++GH  S+T L  S  ++GS  Y++S   D TV    WD+    
Sbjct: 215 NDIKVWDLRQNKLTYTMRGHADSVTGLSLS--SEGS--YLLSNAMDNTVRV--WDVRPFA 268

Query: 310 FSPRPLKFTEKPRPGVQ--MLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESH 367
              R +K  +      +  +L  S+S  G  +A GS D  +  Y     +   + +L  H
Sbjct: 269 PKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFV--YVWDTTSRRILYKLPGH 326

Query: 368 TDKVDSIQFCNNGDRFLSGSRD 389
              ++ + F  +    +S S D
Sbjct: 327 AGSINEVAFHPDEPIIISASSD 348


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  103 bits (258), Expect = 1e-21
 Identities = 81/316 (25%), Positives = 142/316 (44%), Gaps = 27/316 (8%)

Query: 182 ILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENT 241
           ++GH  AV  V F   G  + + S D L+ IW  ++G+   TL GH+ EISD+A + +++
Sbjct: 37  LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96

Query: 242 MIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFW 301
            + + S DK +++W +R+   +  L+GH+  +    F+P        ++S   D TV  W
Sbjct: 97  RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP----PSNLIISGSFDETVKIW 152

Query: 302 QWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKI 361
           +          + L     P   V   CS     G  + +GS D + R++        K 
Sbjct: 153 EVKTGKCL---KTLSAHSDPVSAVHFNCS-----GSLIVSGSYDGLCRIWDAASGQCLKT 204

Query: 362 AELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEE 421
             ++     V  ++F  NG   L+ + D T ++W +     R   L   T   G  + + 
Sbjct: 205 L-VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYS----RGRCLKTYT---GHKNEKY 256

Query: 422 ERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDS 481
             F    VT   W      +V+   D+++ +WN  T +++  L GH D V     HP ++
Sbjct: 257 CIFANFSVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN 310

Query: 482 RIMLSA-GHDGSIFIW 496
            I  +A  +D +I +W
Sbjct: 311 LIASAALENDKTIKLW 326



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 66/284 (23%), Positives = 124/284 (43%), Gaps = 31/284 (10%)

Query: 217 NGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSL 276
           N  L  TL GH+  +S +  +     +A+ S D++I +W          L GH   I+ +
Sbjct: 30  NYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDV 89

Query: 277 QFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGG 336
            +S         +VS   D T+    WD+ S K   + LK          + C +F+   
Sbjct: 90  AWS----SDSSRLVSASDDKTLKL--WDVRSGK-CLKTLKGHSN-----YVFCCNFNPPS 137

Query: 337 MFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWR 396
             + +GS D  ++++ +  +  + +  L +H+D V ++ F  +G   +SGS DG  RIW 
Sbjct: 138 NLIISGSFDETVKIWEV--KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195

Query: 397 FEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSY 456
               +    L+D                  P V+ + ++ N   ++TA  D+ LK+W+  
Sbjct: 196 AASGQCLKTLVDDD---------------NPPVSFVKFSPNGKYILTATLDNTLKLWDYS 240

Query: 457 TGQLLHNLMGHADEVFVLETH--PFDSRIMLSAGHDGSIFIWDI 498
            G+ L    GH +E + +  +      + ++S   D  ++IW++
Sbjct: 241 RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 284



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 62/260 (23%), Positives = 114/260 (43%), Gaps = 48/260 (18%)

Query: 177 KMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAV 236
           K  + + GH   +  VA+     R+ + SDD  +K+W   +G+ L TL+GHS  +     
Sbjct: 74  KYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNF 133

Query: 237 NYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADG 296
           N  + +I +GS D+ +++W ++T   +  L  H+  ++++ F+    GS   +VS   DG
Sbjct: 134 NPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFN--CSGS--LIVSGSYDG 189

Query: 297 TVCFWQW---------------DLESLKFSP----------------------RPLKFTE 319
               W                  +  +KFSP                      R LK   
Sbjct: 190 LCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT 249

Query: 320 KPRPGVQMLCSSFSV-GGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCN 378
             +     + ++FSV GG ++ +GS D+++  Y    +  E + +L+ HTD V S   C+
Sbjct: 250 GHKNEKYCIFANFSVTGGKWIVSGSEDNLV--YIWNLQTKEIVQKLQGHTDVVISAA-CH 306

Query: 379 NGDRFLSGS---RDGTARIW 395
             +  ++ +    D T ++W
Sbjct: 307 PTENLIASAALENDKTIKLW 326



 Score = 52.8 bits (125), Expect = 4e-06
 Identities = 52/232 (22%), Positives = 85/232 (36%), Gaps = 64/232 (27%)

Query: 364 LESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEER 423
           L  HT+ V S++F  NG+   S S D    IW     ++   L      IS         
Sbjct: 37  LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISD-------- 88

Query: 424 FMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHP----- 478
                   +AW+ + S +V+A +D  LK+W+  +G+ L  L GH++ VF    +P     
Sbjct: 89  --------VAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLI 140

Query: 479 ----FDSRI--------------------------------MLSAGHDGSIFIWDITKGT 502
               FD  +                                ++S  +DG   IWD   G 
Sbjct: 141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ 200

Query: 503 KMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFG---CSKPY 551
            +K    +++       F  KFS +G++         L ++ +    C K Y
Sbjct: 201 CLK---TLVDDDNPPVSF-VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY 248


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 80/341 (23%), Positives = 153/341 (44%), Gaps = 27/341 (7%)

Query: 157 QLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTH 216
           Q T  S+ + + P  +  +  +   + GH  AV  V F   G  + + S D L+KIW  +
Sbjct: 16  QPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY 75

Query: 217 NGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSL 276
           +G+   T+ GH   ISD+A + ++ ++ + S DK +++W + +   +  L+GH+  +   
Sbjct: 76  DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135

Query: 277 QFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGG 336
            F+P +      +VS   D +V    WD+++ K   + L     P   V      F+  G
Sbjct: 136 NFNPQS----NLIVSGSFDESVRI--WDVKTGK-CLKTLPAHSDPVSAVH-----FNRDG 183

Query: 337 MFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWR 396
             + + S D + R++        K   ++     V  ++F  NG   L+ + D T ++W 
Sbjct: 184 SLIVSSSYDGLCRIWDTASGQCLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242

Query: 397 FEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSY 456
           + + +            +G  + +   F    VT   W      +V+   D+++ +WN  
Sbjct: 243 YSKGK-------CLKTYTGHKNEKYCIFANFSVTGGKW------IVSGSEDNLVYIWNLQ 289

Query: 457 TGQLLHNLMGHADEVFVLETHPFDSRIMLSA-GHDGSIFIW 496
           T +++  L GH D V     HP ++ I  +A  +D +I +W
Sbjct: 290 TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 56.6 bits (135), Expect = 3e-07
 Identities = 54/237 (22%), Positives = 91/237 (38%), Gaps = 74/237 (31%)

Query: 364 LESHTDKVDSIQFCNNGDRFLSGSRDGTARIW-----RFEQLEWRSILLDMATRISGDLS 418
           L  HT  V S++F  NG+   S S D   +IW     +FE+             ISG   
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT------------ISGH-- 86

Query: 419 SEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHP 478
                  K  ++ +AW+ + +++V+A +D  LK+W+  +G+ L  L GH++ VF    +P
Sbjct: 87  -------KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139

Query: 479 F-----------------------------------------DSRIMLSAGHDGSIFIWD 497
                                                     D  +++S+ +DG   IWD
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199

Query: 498 ITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFG---CSKPY 551
              G  +K    +I+       F  KFS +G++         L ++ +    C K Y
Sbjct: 200 TASGQCLK---TLIDDDNPPVSF-VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 80/341 (23%), Positives = 153/341 (44%), Gaps = 27/341 (7%)

Query: 157 QLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTH 216
           Q T  S+ + + P  +  +  +   + GH  AV  V F   G  + + S D L+KIW  +
Sbjct: 16  QPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY 75

Query: 217 NGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSL 276
           +G+   T+ GH   ISD+A + ++ ++ + S DK +++W + +   +  L+GH+  +   
Sbjct: 76  DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135

Query: 277 QFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGG 336
            F+P +      +VS   D +V    WD+++ K   + L     P   V      F+  G
Sbjct: 136 NFNPQS----NLIVSGSFDESVRI--WDVKTGK-CLKTLPAHSDPVSAVH-----FNRDG 183

Query: 337 MFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWR 396
             + + S D + R++        K   ++     V  ++F  NG   L+ + D T ++W 
Sbjct: 184 SLIVSSSYDGLCRIWDTASGQCLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242

Query: 397 FEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSY 456
           + + +            +G  + +   F    VT   W      +V+   D+++ +WN  
Sbjct: 243 YSKGK-------CLKTYTGHKNEKYCIFANFSVTGGKW------IVSGSEDNLVYIWNLQ 289

Query: 457 TGQLLHNLMGHADEVFVLETHPFDSRIMLSA-GHDGSIFIW 496
           T +++  L GH D V     HP ++ I  +A  +D +I +W
Sbjct: 290 TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 56.6 bits (135), Expect = 3e-07
 Identities = 54/237 (22%), Positives = 91/237 (38%), Gaps = 74/237 (31%)

Query: 364 LESHTDKVDSIQFCNNGDRFLSGSRDGTARIW-----RFEQLEWRSILLDMATRISGDLS 418
           L  HT  V S++F  NG+   S S D   +IW     +FE+             ISG   
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT------------ISGH-- 86

Query: 419 SEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHP 478
                  K  ++ +AW+ + +++V+A +D  LK+W+  +G+ L  L GH++ VF    +P
Sbjct: 87  -------KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139

Query: 479 F-----------------------------------------DSRIMLSAGHDGSIFIWD 497
                                                     D  +++S+ +DG   IWD
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199

Query: 498 ITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFG---CSKPY 551
              G  +K    +I+       F  KFS +G++         L ++ +    C K Y
Sbjct: 200 TASGQCLK---TLIDDDNPPVSF-VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 98.2 bits (243), Expect = 8e-20
 Identities = 63/223 (28%), Positives = 101/223 (45%), Gaps = 15/223 (6%)

Query: 180 RRILGHLSAVYCVAFDRTGHRIF-TGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNY 238
           + I+ H S V  +   +   R+  TG DDC V +WS +    + +L GH++ +  + +N 
Sbjct: 14  QEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNT 73

Query: 239 ENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTV 298
              +I AGS    IRVW L     +  L GH  +I SL F P  +    ++ S   D  +
Sbjct: 74  PEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGE----FVASGSQDTNI 129

Query: 299 CFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAP 358
             W    +   F  R             + C  FS  G +LA+ + DH ++++ L   A 
Sbjct: 130 KLWDIRRKGCVFRYR--------GHSQAVRCLRFSPDGKWLASAADDHTVKLWDL--TAG 179

Query: 359 EKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE 401
           + ++E   HT  V+ ++F  N     SGS D T R W  E+ +
Sbjct: 180 KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQ 222



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 70/292 (23%), Positives = 129/292 (44%), Gaps = 25/292 (8%)

Query: 91  KEIPPSISRVTSL-LGAGRQSLLRTA-KDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPN 148
           +EI    S V+SL LG     LL T   DCR  +W      ++++         + SP  
Sbjct: 14  QEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLW------SINKPNCIMSLTGHTSPVE 67

Query: 149 LVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDC 208
            V ++  ++L    + S +      +  K+ R ++GH + +  + F   G  + +GS D 
Sbjct: 68  SVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127

Query: 209 LVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQG 268
            +K+W       +   RGHS  +  +  + +   +A+ + D  +++W L     ++   G
Sbjct: 128 NIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG 187

Query: 269 HTGSITSLQFSPMAKGSQRYMVSTG-ADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQM 327
           HTG +  ++F P       Y++++G +D T+ F  WDLE  +          +P P   +
Sbjct: 188 HTGPVNVVEFHP-----NEYLLASGSSDRTIRF--WDLEKFQVVS---CIEGEPGPVRSV 237

Query: 328 LCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNN 379
           L   F+  G  L +G  D  +R+Y  G+E       +  +  KV  +  CN+
Sbjct: 238 L---FNPDGCCLYSGCQDS-LRVY--GWEPERCFDVVLVNWGKVADLAICND 283



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 58/238 (24%), Positives = 101/238 (42%), Gaps = 39/238 (16%)

Query: 336 GMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW 395
           G  LATG  D  + ++ +    P  I  L  HT  V+S++     +  ++GS+ G+ R+W
Sbjct: 33  GRLLATGGDDCRVNLWSIN--KPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVW 90

Query: 396 RFEQLE-WRSILLDMATRISGDLSSEEE-------------------------RFMKPKV 429
             E  +  R+++   A   S D     E                         R     V
Sbjct: 91  DLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAV 150

Query: 430 TMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGH 489
             + ++ +   + +A +DH +K+W+   G+++    GH   V V+E HP +  ++ S   
Sbjct: 151 RCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHP-NEYLLASGSS 209

Query: 490 DGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDG--QHFACTDSHGHLLIFGF 545
           D +I  WD+ K        + IEG+  G V    F+ DG   +  C DS   L ++G+
Sbjct: 210 DRTIRFWDLEK----FQVVSCIEGE-PGPVRSVLFNPDGCCLYSGCQDS---LRVYGW 259


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 98.2 bits (243), Expect = 8e-20
 Identities = 85/307 (27%), Positives = 137/307 (44%), Gaps = 31/307 (10%)

Query: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
           H   V   AF   G  + TGS+D  V  W T +G+LL  L GH+  +     + +  + A
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79

Query: 245 AGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWD 304
           + SCD  +R+W +     + VL+GH  S+ ++ FSP      R + S G D  V    WD
Sbjct: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSP----DSRQLASGGWDKRVML--WD 133

Query: 305 LESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAE- 363
           ++    S + L+     R  +Q   S FS     LATGS D  + ++ L    P    + 
Sbjct: 134 VQ----SGQMLRLLVGHRDSIQ--SSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187

Query: 364 LESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEER 423
           LE H+  +  + +  +G    SGS D T  IW+       S+L+ +   ++         
Sbjct: 188 LEGHSANISCLCYSASG-LLASGSWDKTIHIWK---PTTSSLLIQLKGHVTW-------- 235

Query: 424 FMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRI 483
                V  IA++ ++  + +A    ++KVW+  TG+ L  L G  D        P D +I
Sbjct: 236 -----VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTP-DGKI 289

Query: 484 MLSAGHD 490
           ++S   D
Sbjct: 290 LVSGAAD 296



 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 57/216 (26%), Positives = 96/216 (44%), Gaps = 14/216 (6%)

Query: 181 RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYEN 240
           R+ GH   V    F   GH   + S DC V++W     + L  L+GH   +  ++ + ++
Sbjct: 58  RLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDS 117

Query: 241 TMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGA-DGTVC 299
             +A+G  DK + +W +++   + +L GH  SI S  FSP         ++TG+ D TV 
Sbjct: 118 RQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVN-----CLATGSWDSTVH 172

Query: 300 FWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPE 359
            W   + +   S + L   E     +  LC  +S  G+ LA+GS D  I ++        
Sbjct: 173 IWDLRMVTPAVSHQAL---EGHSANISCLC--YSASGL-LASGSWDKTIHIW--KPTTSS 224

Query: 360 KIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW 395
            + +L+ H   V SI F  +     S       ++W
Sbjct: 225 LLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 260



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 51/221 (23%), Positives = 91/221 (41%), Gaps = 20/221 (9%)

Query: 177 KMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAV 236
           K  R + GH  +V  V+F     ++ +G  D  V +W   +G++L  L GH   I     
Sbjct: 96  KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDF 155

Query: 237 NYENTMIAAGSCDKIIRVWCLRTCAPVA---VLQGHTGSITSLQFSPMAKGSQRYMVSTG 293
           +     +A GS D  + +W LR   P      L+GH+ +I+ L +S              
Sbjct: 156 SPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYS-------------- 201

Query: 294 ADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCS-SFSVGGMFLATGSTDHVIRMYF 352
           A G +    WD     + P       + +  V  + S +FS   ++LA+     +++++ 
Sbjct: 202 ASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW- 260

Query: 353 LGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTAR 393
                 + +  L+   D   +  F  +G   +SG+ D T R
Sbjct: 261 -DCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 37/151 (24%), Positives = 61/151 (40%), Gaps = 21/151 (13%)

Query: 357 APEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW--RFEQLEWRSILLDMATRIS 414
           A  ++     H  +V+S  F  +G   L+GS DG    W  R  QL WR         + 
Sbjct: 10  AVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR---------LG 60

Query: 415 GDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVL 474
           G             V    ++ +  +  +A  D  +++W+    + L  L GH   V  +
Sbjct: 61  GHTGP---------VKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV 111

Query: 475 ETHPFDSRIMLSAGHDGSIFIWDITKGTKMK 505
              P DSR + S G D  + +WD+  G  ++
Sbjct: 112 SFSP-DSRQLASGGWDKRVMLWDVQSGQMLR 141


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 61/224 (27%), Positives = 102/224 (45%), Gaps = 18/224 (8%)

Query: 182 ILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENT 241
           + GH   VY  +F    + + + S+D  V++WS      L   +GH+  + D   +    
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598

Query: 242 MIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFW 301
              +G  D++ R+W      P+ +  GH   +   +F P    +  Y+ +  AD TV  W
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP----NSNYVATGSADRTVRLW 654

Query: 302 QWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKI 361
                    +   ++     +  +  L  +FS  G FLATG+TD  + ++ +G      +
Sbjct: 655 D------VLNGNCVRIFTGHKGPIHSL--TFSPNGRFLATGATDGRVLLWDIGHGL--MV 704

Query: 362 AELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW----RFEQLE 401
            EL+ HTD V S++F  +G+   SGS D T R+W     FE LE
Sbjct: 705 GELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLE 748



 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 75/317 (23%), Positives = 123/317 (38%), Gaps = 50/317 (15%)

Query: 204 GSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPV 263
           G  D  V++WS    +L S       + SD++      +I   S D + R+   +T + +
Sbjct: 488 GFADSTVRVWSVTPKKLRSV-----KQASDLS------LIDKESDDVLERIMDEKTASEL 536

Query: 264 AVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWD----LESLKFSPRPLKFTE 319
            +L GH+G +    FSP     + Y++S+  DGTV  W       L   K    P+  T+
Sbjct: 537 KILYGHSGPVYGASFSP----DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQ 592

Query: 320 KPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNN 379
                       FS  G +  +G  D V R++      P +I     H   V+  +F  N
Sbjct: 593 ------------FSPYGYYFVSGGHDRVARLWATDHYQPLRI--FAGHLADVNCTRFHPN 638

Query: 380 GDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDS 439
            +   +GS D T R+W         +L     RI            K  +  + ++ N  
Sbjct: 639 SNYVATGSADRTVRLW--------DVLNGNCVRIFTG--------HKGPIHSLTFSPNGR 682

Query: 440 IVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDIT 499
            + T   D  + +W+   G ++  L GH D V  L     D  I+ S   D ++ +WD  
Sbjct: 683 FLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLR-FSRDGEILASGSMDNTVRLWDAI 741

Query: 500 KGTKMKHYFNMIEGQGH 516
           K  +     +     GH
Sbjct: 742 KAFEDLETDDFTTATGH 758



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 53/205 (25%), Positives = 90/205 (43%), Gaps = 16/205 (7%)

Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMI 243
           GH   V+   F   G+   +G  D + ++W+T + + L    GH A+++    +  +  +
Sbjct: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV 642

Query: 244 AAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQW 303
           A GS D+ +R+W +     V +  GH G I SL FSP    + R++ +   DG V  W  
Sbjct: 643 ATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSP----NGRFLATGATDGRVLLWDI 698

Query: 304 DLESLKFSPRPLKFTEKPRPGVQMLCS-SFSVGGMFLATGSTDHVIRMYFLGFEAPEKIA 362
               +           + +     +CS  FS  G  LA+GS D+ +R++    +A E + 
Sbjct: 699 GHGLM---------VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD-AIKAFEDL- 747

Query: 363 ELESHTDKVDSIQFCNNGDRFLSGS 387
           E +  T     I    N    L G+
Sbjct: 748 ETDDFTTATGHINLPENSQELLLGT 772



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 37/127 (29%), Positives = 56/127 (44%), Gaps = 4/127 (3%)

Query: 175 HIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDM 234
           H +  R   GHL+ V C  F    + + TGS D  V++W   NG  +    GH   I  +
Sbjct: 616 HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL 675

Query: 235 AVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGA 294
             +     +A G+ D  + +W +     V  L+GHT ++ SL+FS         + S   
Sbjct: 676 TFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS----RDGEILASGSM 731

Query: 295 DGTVCFW 301
           D TV  W
Sbjct: 732 DNTVRLW 738


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 93.2 bits (230), Expect = 3e-18
 Identities = 135/715 (18%), Positives = 255/715 (35%), Gaps = 25/715 (3%)

Query: 1475 SPTQSTSSRTAYLGTHKTSAGISSGVTSGDSSDSAESSERRKRNRPITNGSTLSESEVED 1534
            S + S+ S  +       S+  S    S DSSDS++SS+ +  +    + S+ S+S+ + 
Sbjct: 583  SDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDS 642

Query: 1535 SLATSLSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCG 1594
            S + S  SS +S S +S  SS + +SS  S  S SS+       ++       S  +   
Sbjct: 643  SDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSS-------SSDSSNSSDSSDSSDS 695

Query: 1595 RKATRKRVYLSDSDNNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSES 1654
              ++        SD++S ++ +   + + ++          ++N          + SS+S
Sbjct: 696  SNSSESSDSSDSSDSDSSDSSDSSNSNSSDSD---------SSNSSDSSDSSNSSDSSDS 746

Query: 1655 VCSGRKLPHRNASAVARKKLLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDE 1714
              S       ++S  +      +S D           +  D +     S S  +  + + 
Sbjct: 747  SDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNS 806

Query: 1715 SENRDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSE-EDSKSHDSDHACNRTA 1773
            S++ DS   SD   +  +  +N   S   + S       +SS+  DS S +   + N + 
Sbjct: 807  SDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSD 866

Query: 1774 GPSTSVQKLKAESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDS-----ESE 1828
               +S     ++S S+ +DS    +     ++ + + S    +   SDS DS      SE
Sbjct: 867  SSDSSDSSNSSDS-SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSE 925

Query: 1829 EQDREDGKCHKMEMNPISGNLNCDPIAMSQCSSDHGCETDLDSDDDKIEKPNNFMKDSAS 1888
              +  D        N    + + D    S  S+        DS D      ++    S S
Sbjct: 926  SSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDS 985

Query: 1889 QDNGLSRKISRKRVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDV 1948
             D+  S   S     S+ SDSS       S   +     +    ++ ++     SD  D 
Sbjct: 986  SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDS 1045

Query: 1949 SLENVHTRSKNGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTK 2008
            S  +  + S N          + +       + S   E      +         S+ S  
Sbjct: 1046 SDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDS 1105

Query: 2009 VLSQALNGDSDSEDMLNSEHKHRHTNIHKIDAPSKRKSSSVTSSGEDSKSHIPGSETDRT 2068
              S   +  SDS D  NS      ++    D+     SS  + S E S S      +D +
Sbjct: 1106 SDSSDSSDSSDSSDSSNSSDSSDSSD--SSDSSDSSNSSDSSDSSESSDSSDSSDSSDSS 1163

Query: 2069 FSSESTLAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKR 2128
             SS+S+ +  ++  +N     +      +     +   +  S +    DS ++++     
Sbjct: 1164 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1223

Query: 2129 KRSHPELENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTDNTKTKRRKTKG 2183
              S     N     +  +       SS SSD    ++S  D  D + ++ +   G
Sbjct: 1224 DSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNG 1278



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 128/603 (21%), Positives = 226/603 (37%), Gaps = 43/603 (7%)

Query: 1475 SPTQSTSSRTAYLGTHKTSAGISSGVTSGDSSDSAESSERRKRNRPITNGSTLSESEVED 1534
            S   S SS ++       S+  S    S DSSDS++SS+    +    +  + + S+  D
Sbjct: 737  SSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSD 796

Query: 1535 SLATSLSSSASSSSEES----KESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLA 1590
            S  +S SS++S SS+ S     +SS + +SS+ S  S SSN   +   +          +
Sbjct: 797  SSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSS 856

Query: 1591 NGCGRKATRKRVYLSDSDNNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEENS 1650
            N      +      SDS N+S  +       + N+                  SD   +S
Sbjct: 857  NRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD---------------SSDSSNSS 901

Query: 1651 SSESVCSGRKLPHRNASAVARKKLLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQS 1710
             S+S  S       ++S  +      NS D  +        +  D +     SS+ +  S
Sbjct: 902  DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSD----SSNSSDSS 957

Query: 1711 NVDESENRDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHACN 1770
            N  +S N    S+S+   +  + +++     + +   +      +S + S S DS  + N
Sbjct: 958  NSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSN 1017

Query: 1771 RTAGPSTSVQKLKAESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDSESEEQ 1830
             +   ++S     ++S      S+   S     ++   N+S    +   SDS DS S+  
Sbjct: 1018 SSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS-SDSS 1076

Query: 1831 DREDGKCHKMEMNPISGNLNCDPIAMSQCSSDHGCETDLDSDDDKIEKPNNFMKDSASQD 1890
            D  D      E +  S + N    + S  SSD    +D     D  +  N+    S S D
Sbjct: 1077 DSSDSS----ESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNS----SDSSD 1128

Query: 1891 NGLSRKISRKRVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDVSL 1950
            +  S   S     S  SDSS       S   +     +    ++ ++     SD  D S 
Sbjct: 1129 SSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1188

Query: 1951 ENVHTRSKNGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTKVL 2010
             +  + S +          ++     SD   S      S+           DS  S+   
Sbjct: 1189 SSDSSDSSD----------SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSS 1238

Query: 2011 SQALNGDS-DSEDMLNSEHKHRHTNIHKIDAPSKRKSSSVTSSGEDSKSHIPGSETDRTF 2069
              + + DS +S D  +S      T+    ++ S+ KS +  ++G DS S   GS+++ + 
Sbjct: 1239 DSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHST 1298

Query: 2070 SSE 2072
            S +
Sbjct: 1299 SDD 1301



 Score = 74.7 bits (182), Expect = 1e-12
 Identities = 149/759 (19%), Positives = 265/759 (34%), Gaps = 95/759 (12%)

Query: 1426 QKFNEKLRRSQRFKQRQNCKGDSQP--NKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSR 1483
            QK N   R S+R + R   + ++        + ++ K   S  + I + VG   +    +
Sbjct: 345  QKLNH--RESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDK 402

Query: 1484 TAYLGTHKTSAGISSGVTSGDSSDSAESSERRKRNRPITNGSTLSESEVE-----DSLAT 1538
                G H    G  +  T G+  +     ++ +    + + +T S+S  +     D    
Sbjct: 403  ----GQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDK 458

Query: 1539 SLSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKAT 1598
            S+     +SS+ES  +  A   S  +  SR          A+          NG   K  
Sbjct: 459  SMQGDDPNSSDESNGNDDANSESDNNSSSRGD--------ASYNSDESKDNGNGSDSKGA 510

Query: 1599 RKRVYLSDSD-NNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCS 1657
                  S SD NNS   G        N++          ++  K  SD  ++ SS+S   
Sbjct: 511  EDDDSDSTSDTNNSDSNGNGNNGNDDNDK----------SDSGKGKSDSSDSDSSDS--- 557

Query: 1658 GRKLPHRNASAVARKKLLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESEN 1717
                               NS D     S+  + +  D N      SS +  S+  +S++
Sbjct: 558  ------------------SNSSDS----SDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDS 595

Query: 1718 RDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPST 1777
             DS + SD   +  +  ++     + + S +   + +SS+ DSKS  SD   + ++  S 
Sbjct: 596  SDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSD 655

Query: 1778 SVQKLKAESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDS--ESEEQDREDG 1835
            S     + + S+ +DS          ++ + + S        SDS DS   SE  D  D 
Sbjct: 656  SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDS--------SDSSDSSNSSESSDSSDS 707

Query: 1836 KCHKMEMNPISGNLNCDPIAMSQCSSDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSR 1895
                   +  S N N      S  S         DS D      ++   DS+   N    
Sbjct: 708  SDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDS 767

Query: 1896 KISRKRVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDVSLENVHT 1955
              S     SSDS +S      S+ + +          ++ ++     SD  D S ++  +
Sbjct: 768  SDSSDSSDSSDSSNSSDSNDSSNSSDSS--------DSSNSSDSSNSSDSSD-SSDSSDS 818

Query: 1956 RSKNGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALN 2015
             S N          ++     SD   S +    S+           DS+ S +  S   +
Sbjct: 819  DSSN----------SSDSSNSSDSSDSSNSSDSSDS---SDSSDGSDSDSSNRSDSSNSS 865

Query: 2016 GDSDSEDMLNSEHKHRHTNIHKIDAPSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTL 2075
              SDS D  NS      ++ ++    S    SS +S  + S S      +D + SS+S+ 
Sbjct: 866  DSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSE 925

Query: 2076 AQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPEL 2135
            +  ++  +N     N      +     +   +  S +    DS  +++          + 
Sbjct: 926  SSNSSDNSNSSDSSN------SSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDS 979

Query: 2136 ENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTDNT 2174
             N   S  + +S    D+S  S+   S   SD   + N+
Sbjct: 980  SNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNS 1018



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 124/616 (20%), Positives = 218/616 (35%), Gaps = 59/616 (9%)

Query: 1263 NQHCTNISELSNTSEN----DEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNW 1318
            + + ++ S+ SN+S++    D  N+ D  DS     SS      D   S  ++N  +SN 
Sbjct: 728  SSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSND 787

Query: 1319 KKQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEF 1378
                 +         DS       +  +  D  D  D+         + D+ N     + 
Sbjct: 788  SSNSSD-------SSDSSNSSDSSNSSDSSDSSDSSDSDSS-----NSSDSSNSSDSSDS 835

Query: 1379 CKDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRF 1438
                    S+  +   +  S   S +   S   +      SSD       NE    S   
Sbjct: 836  SNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSS 895

Query: 1439 KQRQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISS 1498
                +   DS  + +  +       S +        +   S SS ++       S+  S 
Sbjct: 896  DSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSD 955

Query: 1499 GVTSGDSSDSAESSERRKR-NRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRA 1557
               S DSS+S++SS+     +   +N S  S+S      + S  SS SS S +S +SS +
Sbjct: 956  SSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1015

Query: 1558 RESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEI 1617
              SS  S  S SSN   +   +    +   S ++     +       SDS ++S  +   
Sbjct: 1016 SNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD--SSDSSDSSDSSDSS 1073

Query: 1618 LKARAGNNRKVLRKCAAVAANKIKLMSDVEENS-SSESVCSGRKLPHRNASAVARKKLLH 1676
              + + ++ +      +  ++     SD  ++S SS+S  S       N+S  +      
Sbjct: 1074 DSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1133

Query: 1677 NSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHAN 1736
            +S D  +     +  E  D +     S S  +  + D S++ DS + SD         ++
Sbjct: 1134 DSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD--------SSD 1185

Query: 1737 GYKSHTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPG 1796
               S   + S       +SS+    S  SD     ++  S S     +   +E +DS   
Sbjct: 1186 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSD-----SSDSSDSSDSSDSSDSNESSDSSDS 1240

Query: 1797 RSGGRKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAM 1856
                   N+   + S        SDS DS S+  D  D +         SGN N      
Sbjct: 1241 SDSSDSSNSSDSSDS--------SDSSDSTSDSNDESDSQSK-------SGNGN------ 1279

Query: 1857 SQCSSDHGCETDLDSD 1872
                 ++G ++D DS+
Sbjct: 1280 -----NNGSDSDSDSE 1290



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 68/322 (21%), Positives = 124/322 (38%), Gaps = 32/322 (9%)

Query: 1447 DSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGVTSGDSS 1506
            DS  +    N       S +    +   S   S SS ++       S+  S    S DSS
Sbjct: 1008 DSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1067

Query: 1507 DSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSSRSGL 1566
            DS++SS+        ++ S  SES      + S  SS SS S +S +SS + +SS  S  
Sbjct: 1068 DSSDSSDS-------SDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1120

Query: 1567 SRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKARAGNNR 1626
            S SS+     +  +   +     +N      + +    SDS ++S  +     + + +  
Sbjct: 1121 SNSSD-----SSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSD-- 1173

Query: 1627 KVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSEDEQSLKS 1686
                  ++ ++N        + + SS+S  S       ++S  +      +S D      
Sbjct: 1174 ------SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1227

Query: 1687 EIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKSHTPAPS 1746
              +  E  D +     S S  +  + D S++ DS S+S+     ++   NG  + +    
Sbjct: 1228 SSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGS---- 1283

Query: 1747 KTKFLKIESSEEDSKSHDSDHA 1768
                     S+ DS+  DS+H+
Sbjct: 1284 --------DSDSDSEGSDSNHS 1297



 Score = 35.4 bits (80), Expect = 0.64
 Identities = 20/47 (42%), Positives = 24/47 (51%)

Query: 816 SSGNESSSSVRHETSCDQSEGSGSSEEDEWRSDRKSESYSESSSDSS 862
           S  ++SS S     S D    S  SE D   SD KS+S   +SSDSS
Sbjct: 605 SDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSS 651



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 19/52 (36%), Positives = 26/52 (50%)

Query: 816 SSGNESSSSVRHETSCDQSEGSGSSEEDEWRSDRKSESYSESSSDSSSRYSD 867
           S  ++SS+S     S D S+ S SS+  + +SD        S SDS S  SD
Sbjct: 593 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSD 644



 Score = 33.1 bits (74), Expect = 3.2
 Identities = 20/49 (40%), Positives = 27/49 (55%), Gaps = 1/49 (2%)

Query: 816 SSGNESSSSVRHETSCDQSEGSGSSEEDEW-RSDRKSESYSESSSDSSS 863
           S+ ++SS S     S D S+ S  S+ D   RSD  + S S  SSDSS+
Sbjct: 827 SNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSN 875



 Score = 32.0 bits (71), Expect = 7.1
 Identities = 21/51 (41%), Positives = 26/51 (50%), Gaps = 2/51 (3%)

Query: 816 SSGNESSSSVRHETSCDQSEGSGSSEEDEWRSDRKSESYSESSSDSSSRYS 866
           S  + SS S     S D S+ S SSE  +  S   S+S S  SSDSS+  S
Sbjct: 675 SDSSSSSDSSNSSDSSDSSDSSNSSESSD--SSDSSDSDSSDSSDSSNSNS 723


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 92/382 (24%), Positives = 159/382 (41%), Gaps = 62/382 (16%)

Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
           GH S V+  A++     + +GS D   +IW+    ++ G     LR      GH      
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236

Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
           +++ +  N + T++A GS D   R+W        + L  H G I +L+++   KG+  Y+
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNK--KGN--YV 291

Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
           +S G D T   W       K   +   F   P   V           M  A+ STD  I 
Sbjct: 292 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQ------NNMTFASCSTDMCIH 342

Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
           +  LG + P K    + HT++V++I++  +G    S S D T +IW  +Q          
Sbjct: 343 VCRLGCDHPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 390

Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
                 D    + +    ++  I W        N N SI++ + + D  +++W+   G  
Sbjct: 391 ------DACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVC 444

Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
            H LM H + V+ +   P D + + S   D  + IW+   G+ +  Y      QG G +F
Sbjct: 445 THTLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSY------QGTGGIF 497

Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
           +  ++  G     + S G + +
Sbjct: 498 EVCWNARGDKVGASASDGSVCV 519



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 41/154 (26%), Positives = 63/154 (40%), Gaps = 12/154 (7%)

Query: 358 PEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRIS 414
           P K   L  H  +V    +    D   SGS D TARIW   +        ++L    R  
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228

Query: 415 G-DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFV 473
           G D+ S ++      VT + WN + +++     D   ++W    G L   L  H   +F 
Sbjct: 229 GHDVPSNKD------VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFA 281

Query: 474 LETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
           L+ +      +LSAG D +  IWD   G   + +
Sbjct: 282 LKWNK-KGNYVLSAGVDKTTIIWDAHTGEAKQQF 314



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 39/154 (25%), Positives = 70/154 (45%), Gaps = 15/154 (9%)

Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
           G  L  CS   T    +M Q   +H  +  H   +Y + +  TG           + + S
Sbjct: 371 GMLLASCSDDMTLKIWSMKQDACVHD-LQAHSKEIYTIKWSPTGPATSNPNSSIMLASAS 429

Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
            D  V++W    G    TL  H   +  +A + +   +A+GS DK + +W  ++ + V  
Sbjct: 430 FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489

Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
            QG TG I  + ++  A+G +  + ++ +DG+VC
Sbjct: 490 YQG-TGGIFEVCWN--ARGDK--VGASASDGSVC 518


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 92/382 (24%), Positives = 159/382 (41%), Gaps = 62/382 (16%)

Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
           GH S V+  A++     + +GS D   +IW+    ++ G     LR      GH      
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236

Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
           +++ +  N + T++A GS D   R+W        + L  H G I +L+++   KG+  Y+
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNK--KGN--YV 291

Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
           +S G D T   W       K   +   F   P   V           M  A+ STD  I 
Sbjct: 292 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQ------NNMTFASCSTDMCIH 342

Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
           +  LG + P K    + HT++V++I++  +G    S S D T +IW  +Q          
Sbjct: 343 VCRLGCDHPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 390

Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
                 D    + +    ++  I W        N N SI++ + + D  +++W+   G  
Sbjct: 391 ------DACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVC 444

Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
            H LM H + V+ +   P D + + S   D  + IW+   G+ +  Y      QG G +F
Sbjct: 445 THTLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSY------QGTGGIF 497

Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
           +  ++  G     + S G + +
Sbjct: 498 EVCWNARGDKVGASASDGSVCV 519



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 41/154 (26%), Positives = 63/154 (40%), Gaps = 12/154 (7%)

Query: 358 PEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRIS 414
           P K   L  H  +V    +    D   SGS D TARIW   +        ++L    R  
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228

Query: 415 G-DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFV 473
           G D+ S ++      VT + WN + +++     D   ++W    G L   L  H   +F 
Sbjct: 229 GHDVPSNKD------VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFA 281

Query: 474 LETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
           L+ +      +LSAG D +  IWD   G   + +
Sbjct: 282 LKWNK-KGNYVLSAGVDKTTIIWDAHTGEAKQQF 314



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 39/154 (25%), Positives = 70/154 (45%), Gaps = 15/154 (9%)

Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
           G  L  CS   T    +M Q   +H  +  H   +Y + +  TG           + + S
Sbjct: 371 GMLLASCSDDMTLKIWSMKQDACVHD-LQAHSKEIYTIKWSPTGPATSNPNSSIMLASAS 429

Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
            D  V++W    G    TL  H   +  +A + +   +A+GS DK + +W  ++ + V  
Sbjct: 430 FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489

Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
            QG TG I  + ++  A+G +  + ++ +DG+VC
Sbjct: 490 YQG-TGGIFEVCWN--ARGDK--VGASASDGSVC 518


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 92/382 (24%), Positives = 159/382 (41%), Gaps = 62/382 (16%)

Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
           GH S V+  A++     + +GS D   +IW+    ++ G     LR      GH      
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236

Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
           +++ +  N + T++A GS D   R+W        + L  H G I +L+++   KG+  Y+
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNK--KGN--YV 291

Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
           +S G D T   W       K   +   F   P   V           M  A+ STD  I 
Sbjct: 292 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQ------NNMTFASCSTDMCIH 342

Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
           +  LG + P K    + HT++V++I++  +G    S S D T +IW  +Q          
Sbjct: 343 VCRLGCDHPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 390

Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
                 D    + +    ++  I W        N N SI++ + + D  +++W+   G  
Sbjct: 391 ------DACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVC 444

Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
            H LM H + V+ +   P D + + S   D  + IW+   G+ +  Y      QG G +F
Sbjct: 445 THTLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSY------QGTGGIF 497

Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
           +  ++  G     + S G + +
Sbjct: 498 EVCWNARGDKVGASASDGSVCV 519



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 41/154 (26%), Positives = 63/154 (40%), Gaps = 12/154 (7%)

Query: 358 PEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRIS 414
           P K   L  H  +V    +    D   SGS D TARIW   +        ++L    R  
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228

Query: 415 G-DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFV 473
           G D+ S ++      VT + WN + +++     D   ++W    G L   L  H   +F 
Sbjct: 229 GHDVPSNKD------VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFA 281

Query: 474 LETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
           L+ +      +LSAG D +  IWD   G   + +
Sbjct: 282 LKWNK-KGNYVLSAGVDKTTIIWDAHTGEAKQQF 314



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 39/154 (25%), Positives = 70/154 (45%), Gaps = 15/154 (9%)

Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
           G  L  CS   T    +M Q   +H  +  H   +Y + +  TG           + + S
Sbjct: 371 GMLLASCSDDMTLKIWSMKQDACVHD-LQAHSKEIYTIKWSPTGPATSNPNSSIMLASAS 429

Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
            D  V++W    G    TL  H   +  +A + +   +A+GS DK + +W  ++ + V  
Sbjct: 430 FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489

Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
            QG TG I  + ++  A+G +  + ++ +DG+VC
Sbjct: 490 YQG-TGGIFEVCWN--ARGDK--VGASASDGSVC 518


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 81/320 (25%), Positives = 133/320 (41%), Gaps = 38/320 (11%)

Query: 225 RGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKG 284
           +GH A I+ + ++     +A  S D  + +W  +  A      GH   +TS+QFSP    
Sbjct: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHG-- 72

Query: 285 SQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGST 344
               + S   D TV  W  D           KF+E       +    FS  G FLAT S 
Sbjct: 73  --NLLASASRDRTVRLWIPDKRG--------KFSEFKAHTAPVRSVDFSADGQFLATASE 122

Query: 345 DHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRS 404
           D  I+++         +  L  HT  V   +F  +G   +S S D T +IW         
Sbjct: 123 DKSIKVW--SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW--------- 171

Query: 405 ILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNL 464
              D   +   +  S+   F       + +N + + + +A +D  +KVW+    +LL + 
Sbjct: 172 ---DTTNKQCVNNFSDSVGF----ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHY 224

Query: 465 MGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGH-GAVFDCK 523
             H+  V  +  HP     +++A  DG++ I D+ +G  +         QGH G VF   
Sbjct: 225 QVHSGGVNCISFHP-SGNYLITASSDGTLKILDLLEGRLIYTL------QGHTGPVFTVS 277

Query: 524 FSQDGQHFACTDSHGHLLIF 543
           FS+ G+ FA   +   +L++
Sbjct: 278 FSKGGELFASGGADTQVLLW 297



 Score = 75.5 bits (184), Expect = 6e-13
 Identities = 60/223 (26%), Positives = 96/223 (43%), Gaps = 16/223 (7%)

Query: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
           H + V  V F   G  + T S+D  +K+WS +  R L +L  H+  +     + +  +I 
Sbjct: 101 HTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIV 160

Query: 245 AGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWD 304
           + S DK I++W       V       G    + F+P    S   + S G+D TV  W   
Sbjct: 161 SCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNP----SGTCIASAGSDQTVKVWDVR 216

Query: 305 LESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAEL 364
           +  L      L+  +    GV   C SF   G +L T S+D  +++  L       I  L
Sbjct: 217 VNKL------LQHYQVHSGGVN--CISFHPSGNYLITASSDGTLKI--LDLLEGRLIYTL 266

Query: 365 ESHTDKVDSIQFCNNGDRFLSGSRDGTARIWR--FEQLEWRSI 405
           + HT  V ++ F   G+ F SG  D    +WR  F++L  + +
Sbjct: 267 QGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGL 309


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 97/385 (25%), Positives = 163/385 (42%), Gaps = 60/385 (15%)

Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMI 243
           GH  AV  VAF  TG  + +GS D  V+ W         T +GH   +  ++ + +   +
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKL 171

Query: 244 AAGSCDKIIRVWCLRTCAPVA-VLQGHTGSITSLQFSPM-AKGSQRYMVSTGADGTVCFW 301
           A+G  +  I +W   T   V   L GH+  IT L + P+ A    RY+ S+  DG+V  W
Sbjct: 172 ASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIW 231

Query: 302 ---------------------QWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLA 340
                                +W  + L +S    +  +  R    +LC +    G ++ 
Sbjct: 232 DTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVN 291

Query: 341 TG--STDHVIRMYFLGFEAPE----------KIAELESHTDKVDSIQFCNNGDRFLSGSR 388
           T   STD+ +R     FE  E           + EL+       ++      +R +SGS 
Sbjct: 292 TMALSTDYALRTG--AFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSD 349

Query: 389 DGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDH 448
           D T  +W     E +  L    TR++G          +  +  + ++ +  IV +A  D 
Sbjct: 350 DFTLFLW--SPAEDKKPL----TRMTGH---------QALINQVLFSPDSRIVASASFDK 394

Query: 449 VLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYF 508
            +K+W+  TG+ L +L GH   V+ +     DSR+++S   D ++ +WD+ K  K+    
Sbjct: 395 SIKLWDGRTGKYLASLRGHVAAVYQI-AWSADSRLLVSGSSDSTLKVWDV-KAQKL---- 448

Query: 509 NMIEGQGHG-AVFDCKFSQDGQHFA 532
             ++  GH   V+   +S DGQ  A
Sbjct: 449 -AMDLPGHADEVYAVDWSPDGQRVA 472



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 87/367 (23%), Positives = 149/367 (40%), Gaps = 48/367 (13%)

Query: 219 RLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQF 278
           R  S+L GHS  +  +A +     +A+GS D  +R W L T  P    +GH   + S+ +
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164

Query: 279 SPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMF 338
           SP      R + S   +G +    WD  + K   R L    K   G+       +    +
Sbjct: 165 SP----DGRKLASGCKNGQILL--WDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRY 218

Query: 339 LATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFE 398
           +A+ S D  +R++       E+I  L  HT  V  +++  +G    S S+D T ++WR  
Sbjct: 219 VASSSKDGSVRIWDTTAGRCERI--LTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAH 275

Query: 399 Q-------------LEWRSILLDMATR---------------ISGDLSSEEERFMKPKVT 430
                         +   ++  D A R               + G L   +ER +  +  
Sbjct: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALS-RYN 334

Query: 431 MIAWNQNDSIVVTAVNDHVLKVWN-SYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGH 489
           ++   Q    +V+  +D  L +W+ +   + L  + GH   +  +   P DSRI+ SA  
Sbjct: 335 LVR-GQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASF 392

Query: 490 DGSIFIWDITKGTKMKHYFNMIEGQGH-GAVFDCKFSQDGQHFACTDSHGHLLIFGFGCS 548
           D SI +WD   G   K+  ++   +GH  AV+   +S D +      S   L ++     
Sbjct: 393 DKSIKLWD---GRTGKYLASL---RGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446

Query: 549 KPYEKIP 555
           K    +P
Sbjct: 447 KLAMDLP 453



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 57/264 (21%), Positives = 105/264 (39%), Gaps = 60/264 (22%)

Query: 177 KMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAV 236
           +  R + GH  +V C+ +   G  +++ S D  +K+W  H+G L  TL+GH   ++ MA+
Sbjct: 237 RCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMAL 295

Query: 237 NYENTM------------------------------------------IAAGSCDKIIRV 254
           + +  +                                          + +GS D  + +
Sbjct: 296 STDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFL 355

Query: 255 WC-LRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPR 313
           W       P+  + GH   I  + FSP      R + S   D ++  W           R
Sbjct: 356 WSPAEDKKPLTRMTGHQALINQVLFSP----DSRIVASASFDKSIKLWDG---------R 402

Query: 314 PLKFTEKPRPGVQMLCS-SFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVD 372
             K+    R  V  +   ++S     L +GS+D  ++++ +  +A +   +L  H D+V 
Sbjct: 403 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV--KAQKLAMDLPGHADEVY 460

Query: 373 SIQFCNNGDRFLSGSRDGTARIWR 396
           ++ +  +G R  SG +D   RIWR
Sbjct: 461 AVDWSPDGQRVASGGKDKCLRIWR 484



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 41/155 (26%), Positives = 74/155 (47%), Gaps = 4/155 (2%)

Query: 148 NLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDD 207
           NLV     ++L   S   T F  +  +  K   R+ GH + +  V F      + + S D
Sbjct: 334 NLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFD 393

Query: 208 CLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQ 267
             +K+W    G+ L++LRGH A +  +A + ++ ++ +GS D  ++VW ++       L 
Sbjct: 394 KSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLP 453

Query: 268 GHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQ 302
           GH   + ++ +SP     QR + S G D  +  W+
Sbjct: 454 GHADEVYAVDWSP---DGQR-VASGGKDKCLRIWR 484


>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
           sapiens]
          Length = 1205

 Score = 88.2 bits (217), Expect = 8e-17
 Identities = 73/288 (25%), Positives = 131/288 (45%), Gaps = 36/288 (12%)

Query: 182 ILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEIS--DMAVNYE 239
           I  H   V C AF      I T S D  VKIW++  G L+ T   HS +++      +  
Sbjct: 653 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 712

Query: 240 NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
           + ++A GS D  +++W L        + GHT S+   +FSP      + + S  ADGT+ 
Sbjct: 713 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSP----DDKLLASCSADGTLK 768

Query: 300 FWQWDLESLKFSPRPLKF---TEKPRPGVQML--CSSFSVGGMFLATGSTDHVIRMYFLG 354
            W     + + S    +F    E P+  ++++  C S+S  G  +   + +   +++   
Sbjct: 769 LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN---KIFLWN 825

Query: 355 FEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRIS 414
            ++  K+A+   H   V  + F  +G  FL+ S D T R+W  +++   S ++       
Sbjct: 826 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVM------- 878

Query: 415 GDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHV--LKVWNSYTGQL 460
                     +K +V ++   Q + ++V AV DH+  L++ N  TGQ+
Sbjct: 879 ----------LKQEVDVVF--QENEVMVLAV-DHIRRLQLINGRTGQI 913



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 46/195 (23%), Positives = 81/195 (41%), Gaps = 22/195 (11%)

Query: 367 HTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMK 426
           HTD V    F  +G R  S   D T ++++ E  E    LL++                +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEK---LLEIKAH-------------E 657

Query: 427 PKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLS 486
            +V   A++ +D  + T   D  +K+WNS TG+L+H    H+++V           ++L+
Sbjct: 658 DEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLA 717

Query: 487 AG-HDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGF 545
            G  D  + +WD+ +       F       H     C+FS D +  A   + G L ++  
Sbjct: 718 TGSSDCFLKLWDLNQKECRNTMFGHTNSVNH-----CRFSPDDKLLASCSADGTLKLWDA 772

Query: 546 GCSKPYEKIPDQMFF 560
             +   + I  + FF
Sbjct: 773 TSANERKSINVKQFF 787



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 77/370 (20%), Positives = 136/370 (36%), Gaps = 80/370 (21%)

Query: 184  GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNG------------------------- 218
            GHLS V+ V F   G    T SDD  +++W T                            
Sbjct: 837  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 896

Query: 219  ----RLLSTLRGHS--------AEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVL 266
                R L  + G +        A++S   ++     IA G  +  I +  L         
Sbjct: 897  VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 956

Query: 267  QGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQ 326
              H  ++  +QF+      ++ ++S+  D  +  W W L+   F    L+  ++     +
Sbjct: 957  FQHKKTVWHIQFT----ADEKTLISSSDDAEIQVWNWQLDKCIF----LRGHQETVKDFR 1008

Query: 327  MLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSG 386
            +L +S  +   F  T    ++I           K  +   H   V S    ++  +F S 
Sbjct: 1009 LLKNSRLLSWSFDGTVKVWNII--------TGNKEKDFVCHQGTVLSCDISHDATKFSST 1060

Query: 387  SRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVN 446
            S D TA+IW F+ L                L   E R     V   A++ + +++ T  +
Sbjct: 1061 SADKTAKIWSFDLL----------------LPLHELRGHNGCVRCSAFSVDSTLLATGDD 1104

Query: 447  DHVLKVWNSYTGQLLH--------NLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDI 498
            +  +++WN   G+LLH            H   V  L   P D ++++SAG  G I  W++
Sbjct: 1105 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP-DGKMLISAG--GYIKWWNV 1161

Query: 499  TKGTKMKHYF 508
              G   + ++
Sbjct: 1162 VTGESSQTFY 1171



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 58/282 (20%), Positives = 115/282 (40%), Gaps = 21/282 (7%)

Query: 224 LRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAK 283
           +R H+  +     + +   IA+   DK ++V+   T   +  ++ H   +    FS    
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFST--- 667

Query: 284 GSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSF--SVGGMFLAT 341
              R++ +   D  V  W      L  +     + E      Q+ C  F  S   + LAT
Sbjct: 668 -DDRFIATCSVDKKVKIWNSMTGELVHT-----YDEHSE---QVNCCHFTNSSHHLLLAT 718

Query: 342 GSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE 401
           GS+D  ++++ L     E    +  HT+ V+  +F  +     S S DGT ++W      
Sbjct: 719 GSSDCFLKLWDL--NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSAN 776

Query: 402 WRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLL 461
            R  +      ++ +   E+   M+  V   +W+ + + ++ A  + +  +WN+ +   +
Sbjct: 777 ERKSINVKQFFLNLEDPQED---MEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKV 832

Query: 462 HNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTK 503
            +  GH   V  +   P D    L++  D +I +W+  K  K
Sbjct: 833 ADCRGHLSWVHGVMFSP-DGSSFLTSSDDQTIRLWETKKVCK 873



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 48/207 (23%), Positives = 90/207 (43%), Gaps = 29/207 (14%)

Query: 332 FSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSG-SRDG 390
           FS  G  +A+   D  ++++    E  EK+ E+++H D+V    F +  DRF++  S D 
Sbjct: 623 FSEDGQRIASCGADKTLQVFKA--ETGEKLLEIKAHEDEVLCCAF-STDDRFIATCSVDK 679

Query: 391 TARIWRFEQLEWRSILLDMATRISGDL-SSEEERFMKPKVTMIAWNQNDSIVVTAVNDHV 449
             +IW                 ++G+L  + +E   +        + +  ++ T  +D  
Sbjct: 680 KVKIW---------------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 724

Query: 450 LKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDIT-----KGTKM 504
           LK+W+    +  + + GH + V      P D +++ S   DG++ +WD T     K   +
Sbjct: 725 LKLWDLNQKECRNTMFGHTNSVNHCRFSP-DDKLLASCSADGTLKLWDATSANERKSINV 783

Query: 505 KHYFNMIEGQGHG---AVFDCKFSQDG 528
           K +F  +E         V  C +S DG
Sbjct: 784 KQFFLNLEDPQEDMEVIVKCCSWSADG 810


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
           sapiens]
          Length = 1194

 Score = 88.2 bits (217), Expect = 8e-17
 Identities = 73/288 (25%), Positives = 131/288 (45%), Gaps = 36/288 (12%)

Query: 182 ILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEIS--DMAVNYE 239
           I  H   V C AF      I T S D  VKIW++  G L+ T   HS +++      +  
Sbjct: 642 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 701

Query: 240 NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
           + ++A GS D  +++W L        + GHT S+   +FSP      + + S  ADGT+ 
Sbjct: 702 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSP----DDKLLASCSADGTLK 757

Query: 300 FWQWDLESLKFSPRPLKF---TEKPRPGVQML--CSSFSVGGMFLATGSTDHVIRMYFLG 354
            W     + + S    +F    E P+  ++++  C S+S  G  +   + +   +++   
Sbjct: 758 LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN---KIFLWN 814

Query: 355 FEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRIS 414
            ++  K+A+   H   V  + F  +G  FL+ S D T R+W  +++   S ++       
Sbjct: 815 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVM------- 867

Query: 415 GDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHV--LKVWNSYTGQL 460
                     +K +V ++   Q + ++V AV DH+  L++ N  TGQ+
Sbjct: 868 ----------LKQEVDVVF--QENEVMVLAV-DHIRRLQLINGRTGQI 902



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 46/195 (23%), Positives = 81/195 (41%), Gaps = 22/195 (11%)

Query: 367 HTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMK 426
           HTD V    F  +G R  S   D T ++++ E  E    LL++                +
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEK---LLEIKAH-------------E 646

Query: 427 PKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLS 486
            +V   A++ +D  + T   D  +K+WNS TG+L+H    H+++V           ++L+
Sbjct: 647 DEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLA 706

Query: 487 AG-HDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGF 545
            G  D  + +WD+ +       F       H     C+FS D +  A   + G L ++  
Sbjct: 707 TGSSDCFLKLWDLNQKECRNTMFGHTNSVNH-----CRFSPDDKLLASCSADGTLKLWDA 761

Query: 546 GCSKPYEKIPDQMFF 560
             +   + I  + FF
Sbjct: 762 TSANERKSINVKQFF 776



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 77/370 (20%), Positives = 136/370 (36%), Gaps = 80/370 (21%)

Query: 184  GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNG------------------------- 218
            GHLS V+ V F   G    T SDD  +++W T                            
Sbjct: 826  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 885

Query: 219  ----RLLSTLRGHS--------AEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVL 266
                R L  + G +        A++S   ++     IA G  +  I +  L         
Sbjct: 886  VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 945

Query: 267  QGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQ 326
              H  ++  +QF+      ++ ++S+  D  +  W W L+   F    L+  ++     +
Sbjct: 946  FQHKKTVWHIQFT----ADEKTLISSSDDAEIQVWNWQLDKCIF----LRGHQETVKDFR 997

Query: 327  MLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSG 386
            +L +S  +   F  T    ++I           K  +   H   V S    ++  +F S 
Sbjct: 998  LLKNSRLLSWSFDGTVKVWNII--------TGNKEKDFVCHQGTVLSCDISHDATKFSST 1049

Query: 387  SRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVN 446
            S D TA+IW F+ L                L   E R     V   A++ + +++ T  +
Sbjct: 1050 SADKTAKIWSFDLL----------------LPLHELRGHNGCVRCSAFSVDSTLLATGDD 1093

Query: 447  DHVLKVWNSYTGQLLH--------NLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDI 498
            +  +++WN   G+LLH            H   V  L   P D ++++SAG  G I  W++
Sbjct: 1094 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP-DGKMLISAG--GYIKWWNV 1150

Query: 499  TKGTKMKHYF 508
              G   + ++
Sbjct: 1151 VTGESSQTFY 1160



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 58/282 (20%), Positives = 115/282 (40%), Gaps = 21/282 (7%)

Query: 224 LRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAK 283
           +R H+  +     + +   IA+   DK ++V+   T   +  ++ H   +    FS    
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFST--- 656

Query: 284 GSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSF--SVGGMFLAT 341
              R++ +   D  V  W      L  +     + E      Q+ C  F  S   + LAT
Sbjct: 657 -DDRFIATCSVDKKVKIWNSMTGELVHT-----YDEHSE---QVNCCHFTNSSHHLLLAT 707

Query: 342 GSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE 401
           GS+D  ++++ L     E    +  HT+ V+  +F  +     S S DGT ++W      
Sbjct: 708 GSSDCFLKLWDL--NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSAN 765

Query: 402 WRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLL 461
            R  +      ++ +   E+   M+  V   +W+ + + ++ A  + +  +WN+ +   +
Sbjct: 766 ERKSINVKQFFLNLEDPQED---MEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKV 821

Query: 462 HNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTK 503
            +  GH   V  +   P D    L++  D +I +W+  K  K
Sbjct: 822 ADCRGHLSWVHGVMFSP-DGSSFLTSSDDQTIRLWETKKVCK 862



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 48/207 (23%), Positives = 90/207 (43%), Gaps = 29/207 (14%)

Query: 332 FSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSG-SRDG 390
           FS  G  +A+   D  ++++    E  EK+ E+++H D+V    F +  DRF++  S D 
Sbjct: 612 FSEDGQRIASCGADKTLQVFKA--ETGEKLLEIKAHEDEVLCCAF-STDDRFIATCSVDK 668

Query: 391 TARIWRFEQLEWRSILLDMATRISGDL-SSEEERFMKPKVTMIAWNQNDSIVVTAVNDHV 449
             +IW                 ++G+L  + +E   +        + +  ++ T  +D  
Sbjct: 669 KVKIW---------------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 713

Query: 450 LKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDIT-----KGTKM 504
           LK+W+    +  + + GH + V      P D +++ S   DG++ +WD T     K   +
Sbjct: 714 LKLWDLNQKECRNTMFGHTNSVNHCRFSP-DDKLLASCSADGTLKLWDATSANERKSINV 772

Query: 505 KHYFNMIEGQGHG---AVFDCKFSQDG 528
           K +F  +E         V  C +S DG
Sbjct: 773 KQFFLNLEDPQEDMEVIVKCCSWSADG 799


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 87/382 (22%), Positives = 158/382 (41%), Gaps = 62/382 (16%)

Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
           GH S V+  A++     + +GS D   +IW+    ++ G     LR      GH      
Sbjct: 179 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 238

Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
           +++ +  N   T++A GS D   R+W        + L  H G I +L+++   KG+  Y+
Sbjct: 239 DVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWN--RKGN--YI 293

Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
           +S G D T   W       K   +   F   P   V    ++        A+ STD  I 
Sbjct: 294 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQNNTT------FASCSTDMCIH 344

Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
           +  LG + P K    + HT++V++I++  +G    S S D T +IW  +Q          
Sbjct: 345 VCRLGCDRPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 392

Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
                 ++   + +    ++  I W        N N +I++ + + D  +++W+   G  
Sbjct: 393 ------EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 446

Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
            H L  H + V+ +   P D + + S   D  + IW+   G  +  Y      +G G +F
Sbjct: 447 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQSGNLVHSY------RGTGGIF 499

Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
           +  ++  G     + S G + +
Sbjct: 500 EVCWNARGDKVGASASDGSVCV 521



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 42/152 (27%), Positives = 63/152 (41%), Gaps = 12/152 (7%)

Query: 360 KIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRISG- 415
           K   L  H  +V    +    D   SGS D TARIW   +        ++L    R  G 
Sbjct: 173 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 232

Query: 416 DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLE 475
           D+ S ++      VT + WN N +++ T   D   ++W    G L   L  H   +F L+
Sbjct: 233 DVPSNKD------VTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALK 285

Query: 476 THPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
            +      +LSAG D +  IWD   G   + +
Sbjct: 286 WNR-KGNYILSAGVDKTTIIWDAHTGEAKQQF 316



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 38/154 (24%), Positives = 70/154 (45%), Gaps = 15/154 (9%)

Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
           G  L  CS   T    +M Q + +H  +  H   +Y + +  TG           + + S
Sbjct: 373 GMLLASCSDDMTLKIWSMKQEVCIHD-LQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 431

Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
            D  V++W    G    TL  H   +  +A + +   +A+GS DK + +W  ++   V  
Sbjct: 432 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 491

Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
            +G TG I  + ++  A+G +  + ++ +DG+VC
Sbjct: 492 YRG-TGGIFEVCWN--ARGDK--VGASASDGSVC 520



 Score = 40.4 bits (93), Expect = 0.020
 Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 1/74 (1%)

Query: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
           H   VY VAF   G  + +GS D  V IW+T +G L+ + RG +  I ++  N     + 
Sbjct: 453 HQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVG 511

Query: 245 AGSCDKIIRVWCLR 258
           A + D  + V  LR
Sbjct: 512 ASASDGSVCVLDLR 525


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 87/382 (22%), Positives = 158/382 (41%), Gaps = 62/382 (16%)

Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
           GH S V+  A++     + +GS D   +IW+    ++ G     LR      GH      
Sbjct: 179 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 238

Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
           +++ +  N   T++A GS D   R+W        + L  H G I +L+++   KG+  Y+
Sbjct: 239 DVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWN--RKGN--YI 293

Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
           +S G D T   W       K   +   F   P   V    ++        A+ STD  I 
Sbjct: 294 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQNNTT------FASCSTDMCIH 344

Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
           +  LG + P K    + HT++V++I++  +G    S S D T +IW  +Q          
Sbjct: 345 VCRLGCDRPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 392

Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
                 ++   + +    ++  I W        N N +I++ + + D  +++W+   G  
Sbjct: 393 ------EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 446

Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
            H L  H + V+ +   P D + + S   D  + IW+   G  +  Y      +G G +F
Sbjct: 447 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQSGNLVHSY------RGTGGIF 499

Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
           +  ++  G     + S G + +
Sbjct: 500 EVCWNARGDKVGASASDGSVCV 521



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 42/152 (27%), Positives = 63/152 (41%), Gaps = 12/152 (7%)

Query: 360 KIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRISG- 415
           K   L  H  +V    +    D   SGS D TARIW   +        ++L    R  G 
Sbjct: 173 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 232

Query: 416 DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLE 475
           D+ S ++      VT + WN N +++ T   D   ++W    G L   L  H   +F L+
Sbjct: 233 DVPSNKD------VTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALK 285

Query: 476 THPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
            +      +LSAG D +  IWD   G   + +
Sbjct: 286 WNR-KGNYILSAGVDKTTIIWDAHTGEAKQQF 316



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 38/154 (24%), Positives = 70/154 (45%), Gaps = 15/154 (9%)

Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
           G  L  CS   T    +M Q + +H  +  H   +Y + +  TG           + + S
Sbjct: 373 GMLLASCSDDMTLKIWSMKQEVCIHD-LQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 431

Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
            D  V++W    G    TL  H   +  +A + +   +A+GS DK + +W  ++   V  
Sbjct: 432 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 491

Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
            +G TG I  + ++  A+G +  + ++ +DG+VC
Sbjct: 492 YRG-TGGIFEVCWN--ARGDK--VGASASDGSVC 520



 Score = 40.4 bits (93), Expect = 0.020
 Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 1/74 (1%)

Query: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
           H   VY VAF   G  + +GS D  V IW+T +G L+ + RG +  I ++  N     + 
Sbjct: 453 HQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVG 511

Query: 245 AGSCDKIIRVWCLR 258
           A + D  + V  LR
Sbjct: 512 ASASDGSVCVLDLR 525


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 87/382 (22%), Positives = 158/382 (41%), Gaps = 62/382 (16%)

Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
           GH S V+  A++     + +GS D   +IW+    ++ G     LR      GH      
Sbjct: 230 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 289

Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
           +++ +  N   T++A GS D   R+W        + L  H G I +L+++   KG+  Y+
Sbjct: 290 DVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWN--RKGN--YI 344

Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
           +S G D T   W       K   +   F   P   V    ++        A+ STD  I 
Sbjct: 345 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQNNTT------FASCSTDMCIH 395

Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
           +  LG + P K    + HT++V++I++  +G    S S D T +IW  +Q          
Sbjct: 396 VCRLGCDRPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 443

Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
                 ++   + +    ++  I W        N N +I++ + + D  +++W+   G  
Sbjct: 444 ------EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 497

Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
            H L  H + V+ +   P D + + S   D  + IW+   G  +  Y      +G G +F
Sbjct: 498 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQSGNLVHSY------RGTGGIF 550

Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
           +  ++  G     + S G + +
Sbjct: 551 EVCWNARGDKVGASASDGSVCV 572



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 42/152 (27%), Positives = 63/152 (41%), Gaps = 12/152 (7%)

Query: 360 KIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRISG- 415
           K   L  H  +V    +    D   SGS D TARIW   +        ++L    R  G 
Sbjct: 224 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 283

Query: 416 DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLE 475
           D+ S ++      VT + WN N +++ T   D   ++W    G L   L  H   +F L+
Sbjct: 284 DVPSNKD------VTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALK 336

Query: 476 THPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
            +      +LSAG D +  IWD   G   + +
Sbjct: 337 WNR-KGNYILSAGVDKTTIIWDAHTGEAKQQF 367



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 38/154 (24%), Positives = 70/154 (45%), Gaps = 15/154 (9%)

Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
           G  L  CS   T    +M Q + +H  +  H   +Y + +  TG           + + S
Sbjct: 424 GMLLASCSDDMTLKIWSMKQEVCIHD-LQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 482

Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
            D  V++W    G    TL  H   +  +A + +   +A+GS DK + +W  ++   V  
Sbjct: 483 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 542

Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
            +G TG I  + ++  A+G +  + ++ +DG+VC
Sbjct: 543 YRG-TGGIFEVCWN--ARGDK--VGASASDGSVC 571



 Score = 40.4 bits (93), Expect = 0.020
 Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 1/74 (1%)

Query: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
           H   VY VAF   G  + +GS D  V IW+T +G L+ + RG +  I ++  N     + 
Sbjct: 504 HQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVG 562

Query: 245 AGSCDKIIRVWCLR 258
           A + D  + V  LR
Sbjct: 563 ASASDGSVCVLDLR 576


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 87/382 (22%), Positives = 158/382 (41%), Gaps = 62/382 (16%)

Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLR------GHSA---- 229
           GH S V+  A++     + +GS D   +IW+    ++ G     LR      GH      
Sbjct: 230 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 289

Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
           +++ +  N   T++A GS D   R+W        + L  H G I +L+++   KG+  Y+
Sbjct: 290 DVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWN--RKGN--YI 344

Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
           +S G D T   W       K   +   F   P   V    ++        A+ STD  I 
Sbjct: 345 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQNNTT------FASCSTDMCIH 395

Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
           +  LG + P K    + HT++V++I++  +G    S S D T +IW  +Q          
Sbjct: 396 VCRLGCDRPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---------- 443

Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
                 ++   + +    ++  I W        N N +I++ + + D  +++W+   G  
Sbjct: 444 ------EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 497

Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
            H L  H + V+ +   P D + + S   D  + IW+   G  +  Y      +G G +F
Sbjct: 498 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQSGNLVHSY------RGTGGIF 550

Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
           +  ++  G     + S G + +
Sbjct: 551 EVCWNARGDKVGASASDGSVCV 572



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 42/152 (27%), Positives = 63/152 (41%), Gaps = 12/152 (7%)

Query: 360 KIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE---WRSILLDMATRISG- 415
           K   L  H  +V    +    D   SGS D TARIW   +        ++L    R  G 
Sbjct: 224 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 283

Query: 416 DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLE 475
           D+ S ++      VT + WN N +++ T   D   ++W    G L   L  H   +F L+
Sbjct: 284 DVPSNKD------VTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALK 336

Query: 476 THPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
            +      +LSAG D +  IWD   G   + +
Sbjct: 337 WNR-KGNYILSAGVDKTTIIWDAHTGEAKQQF 367



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 38/154 (24%), Positives = 70/154 (45%), Gaps = 15/154 (9%)

Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHR---------IFTGS 205
           G  L  CS   T    +M Q + +H  +  H   +Y + +  TG           + + S
Sbjct: 424 GMLLASCSDDMTLKIWSMKQEVCIHD-LQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 482

Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
            D  V++W    G    TL  H   +  +A + +   +A+GS DK + +W  ++   V  
Sbjct: 483 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 542

Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
            +G TG I  + ++  A+G +  + ++ +DG+VC
Sbjct: 543 YRG-TGGIFEVCWN--ARGDK--VGASASDGSVC 571



 Score = 40.4 bits (93), Expect = 0.020
 Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 1/74 (1%)

Query: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
           H   VY VAF   G  + +GS D  V IW+T +G L+ + RG +  I ++  N     + 
Sbjct: 504 HQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVG 562

Query: 245 AGSCDKIIRVWCLR 258
           A + D  + V  LR
Sbjct: 563 ASASDGSVCVLDLR 576


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 83.2 bits (204), Expect = 3e-15
 Identities = 86/382 (22%), Positives = 159/382 (41%), Gaps = 62/382 (16%)

Query: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS----THNGRLLSTLRG----------HSA 229
           GH S V+  A++     + +GS D   +IW+    + +G     LR            + 
Sbjct: 167 GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNK 226

Query: 230 EISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYM 289
           +++ +  N E T++A GS D   R+W  +     + L  H G I +L+++   KG+  ++
Sbjct: 227 DVTSLDWNSEGTLLATGSYDGFARIWT-KDGNLASTLGQHKGPIFALKWNK--KGN--FI 281

Query: 290 VSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIR 349
           +S G D T   W       K   +   F   P   V    ++        A+ STD  I 
Sbjct: 282 LSAGVDKTTIIWDAHTGEAK---QQFPFHSAPALDVDWQSNNT------FASCSTDMCIH 332

Query: 350 MYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 409
           +  LG + P  I   + HT++V++I++   G+   S S D T +IW  +Q          
Sbjct: 333 VCKLGQDRP--IKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQ---------- 380

Query: 410 ATRISGDLSSEEERFMKPKVTMIAW--------NQNDSIVVTAVN-DHVLKVWNSYTGQL 460
                 D    + +    ++  I W        N N ++++ + + D  +++W+   G  
Sbjct: 381 ------DNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGIC 434

Query: 461 LHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVF 520
           +H L  H + V+ +   P D R + S   D  + IW+   G  +  Y      +G G +F
Sbjct: 435 IHTLTKHQEPVYSVAFSP-DGRYLASGSFDKCVHIWNTQTGALVHSY------RGTGGIF 487

Query: 521 DCKFSQDGQHFACTDSHGHLLI 542
           +  ++  G     + S G + +
Sbjct: 488 EVCWNAAGDKVGASASDGSVCV 509



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 42/154 (27%), Positives = 63/154 (40%), Gaps = 12/154 (7%)

Query: 358 PEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEW---RSILLDMATRIS 414
           P K   L  H  +V    +    D   SGS D TARIW   +        ++L    R  
Sbjct: 159 PNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREG 218

Query: 415 G-DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFV 473
           G D+ S ++      VT + WN   +++ T   D   ++W    G L   L  H   +F 
Sbjct: 219 GQDVPSNKD------VTSLDWNSEGTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFA 271

Query: 474 LETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHY 507
           L+ +      +LSAG D +  IWD   G   + +
Sbjct: 272 LKWNK-KGNFILSAGVDKTTIIWDAHTGEAKQQF 304



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 40/154 (25%), Positives = 70/154 (45%), Gaps = 15/154 (9%)

Query: 155 GKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGH---------RIFTGS 205
           G  L  CS   T    +M Q   +H  +  H   +Y + +  TG           + + S
Sbjct: 361 GNLLASCSDDMTLKIWSMKQDNCVHD-LQAHNKEIYTIKWSPTGPGTNNPNANLMLASAS 419

Query: 206 DDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAV 265
            D  V++W    G  + TL  H   +  +A + +   +A+GS DK + +W  +T A V  
Sbjct: 420 FDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHS 479

Query: 266 LQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVC 299
            +G TG I  + ++  A G +  + ++ +DG+VC
Sbjct: 480 YRG-TGGIFEVCWN--AAGDK--VGASASDGSVC 508


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 56/241 (23%), Positives = 109/241 (45%), Gaps = 31/241 (12%)

Query: 267 QGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQ 326
           +GH  ++T + FS   K     + S   D  +  W      +K   R  +FT        
Sbjct: 16  KGHRDAVTCVDFSINTK----QLASGSMDSCLMVWH-----MKPQSRAYRFTGHKDA--- 63

Query: 327 MLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSG 386
           + C +FS  G  LA+GS D  +R++    +    +    +HT  V S+ FC++G  F++ 
Sbjct: 64  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQSFVTA 121

Query: 387 SRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVN 446
           S D T ++W   +   +  L  ++  I+              V    ++ +  ++V+A +
Sbjct: 122 SDDKTVKVWATHR---QKFLFSLSQHINW-------------VRCAKFSPDGRLIVSASD 165

Query: 447 DHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKH 506
           D  +K+W+  + + +H+   H   V  ++ HP  + I  +AG D ++ +WD+     ++H
Sbjct: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIA-AAGMDNTVKVWDVRTHRLLQH 224

Query: 507 Y 507
           Y
Sbjct: 225 Y 225



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 65/320 (20%), Positives = 123/320 (38%), Gaps = 33/320 (10%)

Query: 178 MHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVN 237
           + R   GH  AV CV F     ++ +GS D  + +W            GH   ++ +  +
Sbjct: 11  LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70

Query: 238 YENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGT 297
               ++A+GS DK +R+W         V + HT ++ S+ F        +  V+   D T
Sbjct: 71  PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFC----SDGQSFVTASDDKT 126

Query: 298 VCFWQWDLESLKFS-PRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFE 356
           V  W    +   FS  + + +           C+ FS  G  + + S D  ++++     
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVR---------CAKFSPDGRLIVSASDDKTVKLW--DKS 175

Query: 357 APEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGD 416
           + E +     H   V  + F  +G    +   D T ++W            D+ T     
Sbjct: 176 SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW------------DVRTH---- 219

Query: 417 LSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLET 476
              +  +     V  ++++ + + ++TA +D  LK+ +   G+LL+ L GH      +  
Sbjct: 220 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV-A 278

Query: 477 HPFDSRIMLSAGHDGSIFIW 496
                    S G D  + +W
Sbjct: 279 FSRTGEYFASGGSDEQVMVW 298


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,141,331
Number of Sequences: 37866
Number of extensions: 4225588
Number of successful extensions: 23114
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 346
Number of HSP's successfully gapped in prelim test: 494
Number of HSP's that attempted gapping in prelim test: 14865
Number of HSP's gapped (non-prelim): 5670
length of query: 2269
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2151
effective length of database: 13,779,330
effective search space: 29639338830
effective search space used: 29639338830
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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