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Search of human proteins with 16418439
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16418439 WD repeat and FYVE domain containing 2 [Homo
sapiens]
(400 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens] 837 0.0
gi|18482373 WD repeat and FYVE domain containing 1 [Homo sapiens] 570 e-163
gi|4758528 hepatocyte growth factor-regulated tyrosine kinase su... 75 8e-14
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 69 1e-11
gi|21071067 TBP-associated factor 5 [Homo sapiens] 58 2e-08
gi|32189425 WD repeat domain 69 [Homo sapiens] 57 3e-08
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 56 7e-08
gi|55741864 zinc finger, FYVE domain containing 28 [Homo sapiens] 55 9e-08
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform... 55 9e-08
gi|26665869 WD repeat domain 51B [Homo sapiens] 55 9e-08
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 55 1e-07
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 55 1e-07
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 55 1e-07
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 55 1e-07
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 54 2e-07
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 54 2e-07
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 54 2e-07
gi|113865883 WD repeat domain 38 [Homo sapiens] 53 6e-07
gi|30795182 zinc finger, FYVE domain containing 1 isoform 2 [Hom... 53 6e-07
gi|30795180 zinc finger, FYVE domain containing 1 isoform 1 [Hom... 53 6e-07
gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens] 52 7e-07
gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens] 52 7e-07
gi|13375827 phafin 2 [Homo sapiens] 52 7e-07
gi|31317270 WD repeat and FYVE domain containing 3 isoform 3 [Ho... 52 7e-07
gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Ho... 52 7e-07
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 52 7e-07
gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo s... 52 1e-06
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 51 2e-06
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 51 2e-06
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 51 2e-06
>gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens]
Length = 400
Score = 837 bits (2163), Expect = 0.0
Identities = 400/400 (100%), Positives = 400/400 (100%)
Query: 1 MAAEIQPKPLTRKPILLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYW 60
MAAEIQPKPLTRKPILLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYW
Sbjct: 1 MAAEIQPKPLTRKPILLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYW 60
Query: 61 PSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMI 120
PSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMI
Sbjct: 61 PSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMI 120
Query: 121 LFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDHSGQVT 180
LFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDHSGQVT
Sbjct: 121 LFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDHSGQVT 180
Query: 181 ILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQG 240
ILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQG
Sbjct: 181 ILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQG 240
Query: 241 HNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQ 300
HNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQ
Sbjct: 241 HNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQ 300
Query: 301 MWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDEERAPTA 360
MWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDEERAPTA
Sbjct: 301 MWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDEERAPTA 360
Query: 361 TFHDSKHNIVHVHFDATRGWLLTSGTDKVIKLWDMTPVVS 400
TFHDSKHNIVHVHFDATRGWLLTSGTDKVIKLWDMTPVVS
Sbjct: 361 TFHDSKHNIVHVHFDATRGWLLTSGTDKVIKLWDMTPVVS 400
>gi|18482373 WD repeat and FYVE domain containing 1 [Homo sapiens]
Length = 410
Score = 570 bits (1470), Expect = e-163
Identities = 247/399 (61%), Positives = 324/399 (81%)
Query: 1 MAAEIQPKPLTRKPILLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYW 60
MAAEI +P + +P+LL ++EG Q+ V A+++PKE+GVI+ SEDRT+RVWLKRDSGQYW
Sbjct: 1 MAAEIHSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYW 60
Query: 61 PSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMI 120
PS+YH M SPCS M+++ ++RR+ +G DNG + EF +SED+NKM +K Y AHQ+RV+ I
Sbjct: 61 PSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAI 120
Query: 121 LFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDHSGQVT 180
+F L EWV+STG DK +W C+ SG LG + ++ AS LQ+D +T++ F+GD+SGQ+T
Sbjct: 121 IFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQIT 180
Query: 181 ILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQG 240
+LKLEQ C+++TT +GH G V L WDP+QR+LFSG+SD+S+IMWDIGGRKG + LQG
Sbjct: 181 LLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQG 240
Query: 241 HNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQ 300
H+D+VQ+L Y Q TRQL+SC DGGI VWNMDV R+E P+WL+SDSCQKC+QPFFWN KQ
Sbjct: 241 HHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVSREEAPQWLESDSCQKCEQPFFWNIKQ 300
Query: 301 MWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDEERAPTA 360
MWD+K +GLRQHHCRKCG+AVCGKCSSKRSS P+MGFEF+VRVCDSC+++I DE+R A
Sbjct: 301 MWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDEDRTSLA 360
Query: 361 TFHDSKHNIVHVHFDATRGWLLTSGTDKVIKLWDMTPVV 399
TFH+ KHNI H+ D RG ++T GTD+++K+WDMTPVV
Sbjct: 361 TFHEGKHNISHMSMDIARGLMVTCGTDRIVKIWDMTPVV 399
>gi|4758528 hepatocyte growth factor-regulated tyrosine kinase
substrate [Homo sapiens]
Length = 777
Score = 75.5 bits (184), Expect = 8e-14
Identities = 32/76 (42%), Positives = 45/76 (59%), Gaps = 11/76 (14%)
Query: 276 QETPEWLDSDSCQKCDQPFFWNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLM 335
+ P+W+D++ C +C F + R+HHCR CG+ CGKCSSK S+IP
Sbjct: 155 ERAPDWVDAEECHRCRVQF-----------GVMTRKHHCRACGQIFCGKCSSKYSTIPKF 203
Query: 336 GFEFEVRVCDSCHEAI 351
G E EVRVC+ C+E +
Sbjct: 204 GIEKEVRVCEPCYEQL 219
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 68.6 bits (166), Expect = 1e-11
Identities = 68/272 (25%), Positives = 112/272 (41%), Gaps = 25/272 (9%)
Query: 39 VISVSEDRTVRVWLKRDSGQYWPSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILS 98
VI+ S D+TVR W W Y C F+P+ + + G D + I
Sbjct: 160 VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC---KFSPDGKYVVSGFD---VDHGICI 213
Query: 99 EDYNKMTPVKNYQAHQSR-VTMILFVLELEWVLSTGQDKQF-AWHCSESGQRLGGYRT-S 155
D +T V + H +R +T F + + V S D+ W + L + S
Sbjct: 214 MDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHS 273
Query: 156 AVASGLQFDVETRHVFIGDHSGQVTILKL---EQENC-TLVTTFRGHTGGVTALCWDPVQ 211
S F + + I + E NC VT +GH G V++ +
Sbjct: 274 NAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS 333
Query: 212 RVLFSGSSDHSVIMWDI--GGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVW 269
L SG D +V +WD+ G RK + L+GHND V ++ + + + ++S D + +W
Sbjct: 334 SFLISGGFDRTVAIWDVAEGYRK---LSLKGHNDWVMDVAISNNKKWILSASKDRTMRLW 390
Query: 270 NMD-------VERQETPEWLDSDSCQKCDQPF 294
N++ V + + L C++CD+PF
Sbjct: 391 NIEEIDEIPLVIKYKKAVGLKLKQCERCDRPF 422
Score = 50.4 bits (119), Expect = 3e-06
Identities = 55/276 (19%), Positives = 109/276 (39%), Gaps = 46/276 (16%)
Query: 129 VLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIG---DHSGQVTILKLE 185
V++ DK E+G+ L R +F + ++V G DH I ++
Sbjct: 160 VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHG----ICIMD 215
Query: 186 QENCTLVTTFRGH-TGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDR 244
EN T V+ + H T +T+ C+DP + + S S D + +WD+ + + H++
Sbjct: 216 AENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNA 275
Query: 245 VQALSYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQMWDS 304
+ + L + D + +WN+ T E+ + +C
Sbjct: 276 ISNCCFTFSGHFLCTSSWDKNLKIWNV-----HTGEFRNCGAC----------------- 313
Query: 305 KKIGLRQHHCRKCGKAVCGKCSSKRSSIPLM--GFEFEVRVCDSCHEAITDEERAPTATF 362
+ L Q H + C R S L+ GF+ V + D + + R +
Sbjct: 314 --VTLMQGH-----EGSVSSCHFARDSSFLISGGFDRTVAIWD-----VAEGYRKLSLKG 361
Query: 363 HDSKHNIVHVHFDATRGWLLTSGTDKVIKLWDMTPV 398
H+ ++ V + W+L++ D+ ++LW++ +
Sbjct: 362 HNDW--VMDVAISNNKKWILSASKDRTMRLWNIEEI 395
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 57.8 bits (138), Expect = 2e-08
Identities = 53/210 (25%), Positives = 92/210 (43%), Gaps = 10/210 (4%)
Query: 63 VYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILF 122
+ + P SF+P+ L ++GT+ + L T + Y+ H V F
Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT----FTCLVGYKGHNYPVWDTQF 593
Query: 123 VLELEWVLSTGQDKQFAWHCSESGQRLGGYRTS-AVASGLQFDVETRHVFIGDHSGQVTI 181
+ +S G D+ ++ Q L + A + +F + +V G V +
Sbjct: 594 SPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRL 653
Query: 182 LKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAI-ELQG 240
+ NC V F GH G + +L + P R L +G++D V++WDIG G + EL+G
Sbjct: 654 WDVLNGNC--VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG--HGLMVGELKG 709
Query: 241 HNDRVQALSYAQHTRQLISCGGDGGIVVWN 270
H D V +L +++ L S D + +W+
Sbjct: 710 HTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 41.2 bits (95), Expect = 0.002
Identities = 20/78 (25%), Positives = 41/78 (52%), Gaps = 3/78 (3%)
Query: 195 FRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIEL-QGHNDRVQALSYAQH 253
F GH V + P + +GS+D +V +WD+ G + + GH + +L+++ +
Sbjct: 623 FAGHLADVNCTRFHPNSNYVATGSADRTVRLWDV--LNGNCVRIFTGHKGPIHSLTFSPN 680
Query: 254 TRQLISCGGDGGIVVWNM 271
R L + DG +++W++
Sbjct: 681 GRFLATGATDGRVLLWDI 698
Score = 32.3 bits (72), Expect = 0.78
Identities = 20/89 (22%), Positives = 39/89 (43%), Gaps = 1/89 (1%)
Query: 184 LEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHND 243
++++ + + GH+G V + P + L S S D +V +W + + +GHN
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL-QTFTCLVGYKGHNY 586
Query: 244 RVQALSYAQHTRQLISCGGDGGIVVWNMD 272
V ++ + +S G D +W D
Sbjct: 587 PVWDTQFSPYGYYFVSGGHDRVARLWATD 615
Score = 29.3 bits (64), Expect = 6.6
Identities = 27/109 (24%), Positives = 42/109 (38%), Gaps = 6/109 (5%)
Query: 27 VNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYWPSVYHAMPSPCSCMSFNPETRRLSIG 86
VN P V + S DRTVR+W + ++ P ++F+P R L+ G
Sbjct: 630 VNCTRFHPNSNYVATGSADRTVRLWDVLNGN--CVRIFTGHKGPIHSLTFSPNGRFLATG 687
Query: 87 LDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFVLELEWVLSTGQD 135
+G +L D V + H V + F + E + S D
Sbjct: 688 ATDGR----VLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMD 732
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 57.0 bits (136), Expect = 3e-08
Identities = 55/219 (25%), Positives = 88/219 (40%), Gaps = 35/219 (15%)
Query: 194 TFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQH 253
TFRGHT + L ++P ++ +GS D + +WDI + L+GH+ + +LS+
Sbjct: 172 TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGE-EVYTLRGHSAEIISLSFNTS 230
Query: 254 TRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQMWDSKKI--GLRQ 311
++I+ D +VVW+ D R+ + C + F WD I G
Sbjct: 231 GDRIITGSFDHTVVVWDADTGRKVN---ILIGHCAEISSASF-----NWDCSLILTGSMD 282
Query: 312 HHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHE----------------AITDEE 355
C K A GKC + L G + E + DSC + +
Sbjct: 283 KTC-KLWDATNGKCVA-----TLTGHDDE--ILDSCFDYTGKLIATASADGTARIFSAAT 334
Query: 356 RAPTATFHDSKHNIVHVHFDATRGWLLTSGTDKVIKLWD 394
R A + I + F+ LLT +DK ++WD
Sbjct: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Score = 48.9 bits (115), Expect = 8e-06
Identities = 51/258 (19%), Positives = 107/258 (41%), Gaps = 15/258 (5%)
Query: 17 LQRMEGSQEVVN-MAVIVPKEEGVISVSEDRTVRVWLKRDSGQYWPSVYHAMPSPCSCMS 75
L +EG + VV +A P + + + S D+T ++W Y + + C+S
Sbjct: 127 LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCY--HTFRGHTAEIVCLS 184
Query: 76 FNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFVLELEWVLSTGQD 135
FNP++ ++ G + T + D V + H + + + F + +++ D
Sbjct: 185 FNPQSTLVATGSMDTTAKLW----DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFD 240
Query: 136 KQFAWHCSESGQRLG---GYRTSAVASGLQFDVETRHVFIGDHSGQVTILKLEQENCTLV 192
+++G+++ G+ A S F+ + + G S T + N V
Sbjct: 241 HTVVVWDADTGRKVNILIGH--CAEISSASFNWDCSLILTG--SMDKTCKLWDATNGKCV 296
Query: 193 TTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQ 252
T GH + C+D +++ + S+D + ++ RK A +L+GH + +S+
Sbjct: 297 ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIA-KLEGHEGEISKISFNP 355
Query: 253 HTRQLISCGGDGGIVVWN 270
L++ D +W+
Sbjct: 356 QGNHLLTGSSDKTARIWD 373
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 55.8 bits (133), Expect = 7e-08
Identities = 30/106 (28%), Positives = 50/106 (47%), Gaps = 3/106 (2%)
Query: 169 HVFIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDI 228
H+ +G G + I L + TF GH +T L +D + L SGS D +I+WD+
Sbjct: 79 HLAVGYEDGSIRIFSLLSGEGNV--TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDV 136
Query: 229 GGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVE 274
G L+GH D + + + L++ G D + W++D +
Sbjct: 137 INESG-LYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQ 181
Score = 39.3 bits (90), Expect = 0.006
Identities = 40/147 (27%), Positives = 59/147 (40%), Gaps = 12/147 (8%)
Query: 87 LDNGTISEFILSEDYNKMTPVKNYQ----AHQSRVTMILFVLELEWVLSTGQDKQFAWHC 142
L N + + L+ PV+ + H+S V + F + VLS D W+
Sbjct: 384 LQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNR 443
Query: 143 SESGQRLGGYRTSAVASGLQ--FDVETRHVFIGDHSGQVTILKLEQENCTLVTTFRGHTG 200
S L RT L F R V IG +G++ + L N L+ T H G
Sbjct: 444 ST----LQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGN--LLETIDAHDG 497
Query: 201 GVTALCWDPVQRVLFSGSSDHSVIMWD 227
+ ++ P QR +G +D SV WD
Sbjct: 498 ALWSMSLSPDQRGFVTGGADKSVKFWD 524
Score = 38.1 bits (87), Expect = 0.014
Identities = 52/221 (23%), Positives = 96/221 (43%), Gaps = 47/221 (21%)
Query: 38 GVISVSEDRTVRVWLKRDSGQYW--PSVYHA----------------MPSPCSCMSFNPE 79
GVI + V V L+ + G+Y P+ H + +C+ +P+
Sbjct: 17 GVIGSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPD 76
Query: 80 TRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFVLELEWVLSTGQDKQ-- 137
L++G ++G+I F L +T + H++ +T + + +L L++G
Sbjct: 77 GLHLAVGYEDGSIRIFSLLSGEGNVT----FNGHKAAITTLKYD-QLGGRLASGSKDTDI 131
Query: 138 FAWHC-SESG-QRLGGYRTSAVASGLQFDVETRHVFIGDH-----SGQVTILK---LEQE 187
W +ESG RL G++ D T+ +F+ + SG+ T++K L+ +
Sbjct: 132 IVWDVINESGLYRLKGHK----------DAITQALFLREKNLLVTSGKDTMVKWWDLDTQ 181
Query: 188 NCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDI 228
+C T GH V L ++ L +G+SD + +WDI
Sbjct: 182 HC--FKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
Score = 34.7 bits (78), Expect = 0.16
Identities = 26/104 (25%), Positives = 44/104 (42%), Gaps = 10/104 (9%)
Query: 198 HTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIE-LQGHNDRVQALSYAQHTRQ 256
H V L + P + F+ DH + WD K I+ L+GH+ + L+ +
Sbjct: 632 HDDSVMYLQFVPKSHLFFTAGKDHKIKQWD--ADKFEHIQTLEGHHQEIWCLAVSPSGDY 689
Query: 257 LISCGGDGGIVVWN-------MDVERQETPEWLDSDSCQKCDQP 293
++S D + +W ++ ER+ E +S K DQP
Sbjct: 690 VVSSSHDKSLRLWERTREPLILEEEREMEREAEYEESVAKEDQP 733
>gi|55741864 zinc finger, FYVE domain containing 28 [Homo sapiens]
Length = 887
Score = 55.5 bits (132), Expect = 9e-08
Identities = 27/80 (33%), Positives = 39/80 (48%), Gaps = 14/80 (17%)
Query: 272 DVERQETPEWLDSDSC---QKCDQPFFWNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSK 328
D + ++ PEW+ ++C C PF + R+HHCR CGK C +CSS
Sbjct: 805 DGDFEDPPEWVPDEACGFCTACKAPF-----------TVIRRKHHCRSCGKIFCSRCSSH 853
Query: 329 RSSIPLMGFEFEVRVCDSCH 348
+ +P G VRVC C+
Sbjct: 854 SAPLPRYGQVKPVRVCTHCY 873
>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
[Homo sapiens]
Length = 1170
Score = 55.5 bits (132), Expect = 9e-08
Identities = 35/114 (30%), Positives = 54/114 (47%), Gaps = 25/114 (21%)
Query: 241 HNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQ 300
+N V +Y T+QL+ +D+ +E P W D C +C F
Sbjct: 1075 NNQGVNIFNYQVATKQLL---------FRLLDMLSKEPP-WCDGSYCYECTARF------ 1118
Query: 301 MWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFE--VRVCDSCHEAIT 352
+ R+HHCR CG+ +C KCS+K IP++ F+ VRVC+ C + +T
Sbjct: 1119 -----GVTTRKHHCRHCGRLLCHKCSTK--EIPIIKFDLNKPVRVCNICFDVLT 1165
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 55.5 bits (132), Expect = 9e-08
Identities = 56/257 (21%), Positives = 110/257 (42%), Gaps = 10/257 (3%)
Query: 19 RMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYWPSVYHAMPSPCSCMSFNP 78
R G ++VV P + S S DRTVR+W+ G++ S + A +P + F+
Sbjct: 55 RYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKF--SEFKAHTAPVRSVDFSA 112
Query: 79 ETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFVLELEWVLSTGQDKQF 138
+ + L+ ++ +I + + Y + Y+ H V F + ++S +DK
Sbjct: 113 DGQFLATASEDKSIKVWSM---YRQRFLYSLYR-HTHWVRCAKFSPDGRLIVSCSEDKTI 168
Query: 139 AWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDHSGQVTILKLEQENCTLVTTFRGH 198
+ + Q + + + +V D I T+ + L+ ++ H
Sbjct: 169 KIWDTTNKQCVNNF-SDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVH 227
Query: 199 TGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAI-ELQGHNDRVQALSYAQHTRQL 257
+GGV + + P L + SSD ++ + D+ +G I LQGH V +S+++
Sbjct: 228 SGGVNCISFHPSGNYLITASSDGTLKILDL--LEGRLIYTLQGHTGPVFTVSFSKGGELF 285
Query: 258 ISCGGDGGIVVWNMDVE 274
S G D +++W + +
Sbjct: 286 ASGGADTQVLLWRTNFD 302
Score = 39.7 bits (91), Expect = 0.005
Identities = 42/218 (19%), Positives = 83/218 (38%), Gaps = 17/218 (7%)
Query: 187 ENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQ 246
E+ L F+GH +T+L P + L + S D +++W+ A GH D V
Sbjct: 6 EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPH-ARAYRYVGHKDVVT 64
Query: 247 ALSYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFK------- 299
++ ++ H L S D + +W D + + + + D F
Sbjct: 65 SVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDK 124
Query: 300 --QMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDEERA 357
++W + R C K S I + +++ D+ ++ +
Sbjct: 125 SIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN---- 180
Query: 358 PTATFHDSKHNIVHVHFDATRGWLLTSGTDKVIKLWDM 395
F DS V F+ + + ++G+D+ +K+WD+
Sbjct: 181 ---NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/103 (32%), Positives = 51/103 (49%), Gaps = 2/103 (1%)
Query: 173 GDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRK 232
G QV I ++ + V T RGH V+ + P Q ++ S S D S+ +WD+ R
Sbjct: 223 GADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRT 282
Query: 233 GTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVER 275
G + H DR L+ A L + G DGG++V+ ++ ER
Sbjct: 283 GVQTFRRDH-DRFWVLA-AHPNLNLFAAGHDGGMIVFKLERER 323
Score = 45.8 bits (107), Expect = 7e-05
Identities = 30/116 (25%), Positives = 50/116 (43%), Gaps = 3/116 (2%)
Query: 155 SAVASGLQFDVETRHVFIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVL 214
SA GL F + + H+G + + + CTL+ F H G V + + Q +
Sbjct: 9 SARVKGLSFHPKRPWILTSLHNGVIQLW--DYRMCTLIDKFDEHDGPVRGIDFHKQQPLF 66
Query: 215 FSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWN 270
SG D+ + +W+ R+ L GH D ++ + ++S D I VWN
Sbjct: 67 VSGGDDYKIKVWNYKLRR-CLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWN 121
Score = 36.2 bits (82), Expect = 0.054
Identities = 54/245 (22%), Positives = 89/245 (36%), Gaps = 43/245 (17%)
Query: 74 MSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFVLELEWVLSTG 133
+SF+P+ + L NG I + DY T + + H V I F + +S G
Sbjct: 15 LSFHPKRPWILTSLHNGVIQLW----DYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGG 70
Query: 134 QD---KQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDHSGQVTILKLEQENCT 190
D K + + L G+ + + + +I S TI ++ T
Sbjct: 71 DDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHE----YPWILSASDDQTIRVWNWQSRT 126
Query: 191 LVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGG---------------RKGTA 235
V GH V + P + ++ S S D +V +WDI G R T
Sbjct: 127 CVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITG 186
Query: 236 IELQGHNDRVQALSYAQHTR------------QLISCGGDGGIVVWNMDVERQETPEWLD 283
++L G D V H R ++S D + +W M+ E+ W +
Sbjct: 187 VDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN----ESKAW-E 241
Query: 284 SDSCQ 288
D+C+
Sbjct: 242 VDTCR 246
Score = 34.7 bits (78), Expect = 0.16
Identities = 23/106 (21%), Positives = 45/106 (42%), Gaps = 4/106 (3%)
Query: 11 TRKPILLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYWPSVYHAMPSP 70
T ++ +EG VN A P ++S ++DR V++W +S + +
Sbjct: 192 TTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNN 251
Query: 71 CSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSR 116
SC F+P + ++ +I + D +K T V+ ++ R
Sbjct: 252 VSCAVFHPRQELILSNSEDKSIRVW----DMSKRTGVQTFRRDHDR 293
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/103 (32%), Positives = 51/103 (49%), Gaps = 2/103 (1%)
Query: 173 GDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRK 232
G QV I ++ + V T RGH V+ + P Q ++ S S D S+ +WD+ R
Sbjct: 223 GADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRT 282
Query: 233 GTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVER 275
G + H DR L+ A L + G DGG++V+ ++ ER
Sbjct: 283 GVQTFRRDH-DRFWVLA-AHPNLNLFAAGHDGGMIVFKLERER 323
Score = 45.8 bits (107), Expect = 7e-05
Identities = 30/116 (25%), Positives = 50/116 (43%), Gaps = 3/116 (2%)
Query: 155 SAVASGLQFDVETRHVFIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVL 214
SA GL F + + H+G + + + CTL+ F H G V + + Q +
Sbjct: 9 SARVKGLSFHPKRPWILTSLHNGVIQLW--DYRMCTLIDKFDEHDGPVRGIDFHKQQPLF 66
Query: 215 FSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWN 270
SG D+ + +W+ R+ L GH D ++ + ++S D I VWN
Sbjct: 67 VSGGDDYKIKVWNYKLRR-CLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWN 121
Score = 36.2 bits (82), Expect = 0.054
Identities = 54/245 (22%), Positives = 89/245 (36%), Gaps = 43/245 (17%)
Query: 74 MSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFVLELEWVLSTG 133
+SF+P+ + L NG I + DY T + + H V I F + +S G
Sbjct: 15 LSFHPKRPWILTSLHNGVIQLW----DYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGG 70
Query: 134 QD---KQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDHSGQVTILKLEQENCT 190
D K + + L G+ + + + +I S TI ++ T
Sbjct: 71 DDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHE----YPWILSASDDQTIRVWNWQSRT 126
Query: 191 LVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGG---------------RKGTA 235
V GH V + P + ++ S S D +V +WDI G R T
Sbjct: 127 CVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITG 186
Query: 236 IELQGHNDRVQALSYAQHTR------------QLISCGGDGGIVVWNMDVERQETPEWLD 283
++L G D V H R ++S D + +W M+ E+ W +
Sbjct: 187 VDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN----ESKAW-E 241
Query: 284 SDSCQ 288
D+C+
Sbjct: 242 VDTCR 246
Score = 34.7 bits (78), Expect = 0.16
Identities = 23/106 (21%), Positives = 45/106 (42%), Gaps = 4/106 (3%)
Query: 11 TRKPILLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYWPSVYHAMPSP 70
T ++ +EG VN A P ++S ++DR V++W +S + +
Sbjct: 192 TTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNN 251
Query: 71 CSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSR 116
SC F+P + ++ +I + D +K T V+ ++ R
Sbjct: 252 VSCAVFHPRQELILSNSEDKSIRVW----DMSKRTGVQTFRRDHDR 293
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 54.7 bits (130), Expect = 1e-07
Identities = 26/78 (33%), Positives = 45/78 (57%), Gaps = 1/78 (1%)
Query: 192 VTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYA 251
+ + RGH V + W R+L SGSSD ++ +WD+ +K A++L GH D V A+ ++
Sbjct: 115 LASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQK-LAMDLPGHADEVYAVDWS 173
Query: 252 QHTRQLISCGGDGGIVVW 269
+++ S G D + +W
Sbjct: 174 PDGQRVASGGKDKCLRIW 191
Score = 45.4 bits (106), Expect = 9e-05
Identities = 24/85 (28%), Positives = 45/85 (52%), Gaps = 3/85 (3%)
Query: 192 VTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAI-ELQGHNDRVQALSY 250
+T GH + + + P R++ S S D S+ +WD GR G + L+GH V +++
Sbjct: 73 LTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD--GRTGKYLASLRGHVAAVYQIAW 130
Query: 251 AQHTRQLISCGGDGGIVVWNMDVER 275
+ +R L+S D + VW++ ++
Sbjct: 131 SADSRLLVSGSSDSTLKVWDVKAQK 155
Score = 30.4 bits (67), Expect = 3.0
Identities = 14/57 (24%), Positives = 26/57 (45%)
Query: 214 LFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWN 270
L SGS D ++ +W K + GH + + ++ +R + S D I +W+
Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 108
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 54.7 bits (130), Expect = 1e-07
Identities = 26/78 (33%), Positives = 45/78 (57%), Gaps = 1/78 (1%)
Query: 192 VTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYA 251
+ + RGH V + W R+L SGSSD ++ +WD+ +K A++L GH D V A+ ++
Sbjct: 407 LASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQK-LAMDLPGHADEVYAVDWS 465
Query: 252 QHTRQLISCGGDGGIVVW 269
+++ S G D + +W
Sbjct: 466 PDGQRVASGGKDKCLRIW 483
Score = 47.0 bits (110), Expect = 3e-05
Identities = 29/112 (25%), Positives = 47/112 (41%), Gaps = 5/112 (4%)
Query: 171 FIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGG 230
++ SG T+ + T T +GH V ++ W P R L SG + +++WD
Sbjct: 128 YLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPST 187
Query: 231 RKGTAIELQGHNDRVQALSYA-----QHTRQLISCGGDGGIVVWNMDVERQE 277
K L GH+ + LS+ R + S DG + +W+ R E
Sbjct: 188 GKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCE 239
Score = 45.4 bits (106), Expect = 9e-05
Identities = 24/85 (28%), Positives = 45/85 (52%), Gaps = 3/85 (3%)
Query: 192 VTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAI-ELQGHNDRVQALSY 250
+T GH + + + P R++ S S D S+ +WD GR G + L+GH V +++
Sbjct: 365 LTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD--GRTGKYLASLRGHVAAVYQIAW 422
Query: 251 AQHTRQLISCGGDGGIVVWNMDVER 275
+ +R L+S D + VW++ ++
Sbjct: 423 SADSRLLVSGSSDSTLKVWDVKAQK 447
Score = 43.5 bits (101), Expect = 3e-04
Identities = 30/112 (26%), Positives = 52/112 (46%), Gaps = 3/112 (2%)
Query: 165 VETRHVFIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVI 224
VET V + Q CT ++ GH+ V ++ + P + L SGS D +V
Sbjct: 82 VETEKVLDIIYQPQAIFRVRAVTRCT--SSLEGHSEAVISVAFSPTGKYLASGSGDTTVR 139
Query: 225 MWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVERQ 276
WD+ + +GH V ++S++ R+L S +G I++W+ +Q
Sbjct: 140 FWDL-STETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQ 190
Score = 30.4 bits (67), Expect = 3.0
Identities = 14/57 (24%), Positives = 26/57 (45%)
Query: 214 LFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWN 270
L SGS D ++ +W K + GH + + ++ +R + S D I +W+
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400
>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 54.3 bits (129), Expect = 2e-07
Identities = 27/71 (38%), Positives = 35/71 (49%), Gaps = 16/71 (22%)
Query: 281 WLDSDS---CQKCDQPFFWNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGF 337
WL D C++C++ F I R+HHCR CG C CSS ++P +
Sbjct: 531 WLKDDEATHCRQCEKEF-----------SISRRKHHCRNCGHIFCNTCSSNELALP--SY 577
Query: 338 EFEVRVCDSCH 348
VRVCDSCH
Sbjct: 578 PKPVRVCDSCH 588
>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 54.3 bits (129), Expect = 2e-07
Identities = 27/71 (38%), Positives = 35/71 (49%), Gaps = 16/71 (22%)
Query: 281 WLDSDS---CQKCDQPFFWNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGF 337
WL D C++C++ F I R+HHCR CG C CSS ++P +
Sbjct: 531 WLKDDEATHCRQCEKEF-----------SISRRKHHCRNCGHIFCNTCSSNELALP--SY 577
Query: 338 EFEVRVCDSCH 348
VRVCDSCH
Sbjct: 578 PKPVRVCDSCH 588
>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
Length = 708
Score = 54.3 bits (129), Expect = 2e-07
Identities = 27/71 (38%), Positives = 35/71 (49%), Gaps = 16/71 (22%)
Query: 281 WLDSDS---CQKCDQPFFWNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGF 337
WL D C++C++ F I R+HHCR CG C CSS ++P +
Sbjct: 639 WLKDDEATHCRQCEKEF-----------SISRRKHHCRNCGHIFCNTCSSNELALP--SY 685
Query: 338 EFEVRVCDSCH 348
VRVCDSCH
Sbjct: 686 PKPVRVCDSCH 696
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 52.8 bits (125), Expect = 6e-07
Identities = 54/267 (20%), Positives = 105/267 (39%), Gaps = 39/267 (14%)
Query: 159 SGLQFDVETRHV-FIGDHSGQVT----------ILKLEQENCT---------LVTTFRGH 198
SG+ + R V F G H G+V +L ++ C L+ GH
Sbjct: 3 SGVPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGH 62
Query: 199 TGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLI 258
TG V + P + S S D +V +WD+ K + L+GH V+ +S++ +RQL
Sbjct: 63 TGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRV-LKGHQRSVETVSFSPDSRQLA 121
Query: 259 SCGGDGGIVVWNMD--------VERQETPEWLDSDSCQKCDQPFFWNFK-QMWDSKKIGL 309
S G D +++W++ V +++ + D C W+ +WD + +
Sbjct: 122 SGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTP 181
Query: 310 RQHHCRKCGKA--VCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDEERAPTATFHDSKH 367
H G + + C S + ++ + + ++ + +
Sbjct: 182 AVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTW------ 235
Query: 368 NIVHVHFDATRGWLLTSGTDKVIKLWD 394
+ + F WL ++G +++K+WD
Sbjct: 236 -VKSIAFSPDELWLASAGYSRMVKVWD 261
Score = 50.1 bits (118), Expect = 4e-06
Identities = 57/248 (22%), Positives = 99/248 (39%), Gaps = 14/248 (5%)
Query: 27 VNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYWPSVYHAMPSPCSCMSFNPETRRLSIG 86
VN + P + +++ SED V W R W H P F+P+ +
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHT--GPVKFCRFSPDGHLFASA 81
Query: 87 LDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFVLELEWVLSTGQDKQFAWHCSESG 146
+ T+ + D + ++ + HQ V + F + + S G DK+ +SG
Sbjct: 82 SCDCTVRLW----DVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG 137
Query: 147 QRLG---GYRTSAVASGLQFDVETRHVFIGDHSGQVTILKLEQENCTLV-TTFRGHTGGV 202
Q L G+R S +S F + G V I L + GH+ +
Sbjct: 138 QMLRLLVGHRDSIQSS--DFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI 195
Query: 203 TALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLISCGG 262
+ LC+ +L SGS D ++ +W I+L+GH V++++++ L S G
Sbjct: 196 SCLCYS-ASGLLASGSWDKTIHIWK-PTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGY 253
Query: 263 DGGIVVWN 270
+ VW+
Sbjct: 254 SRMVKVWD 261
Score = 44.3 bits (103), Expect = 2e-04
Identities = 43/177 (24%), Positives = 73/177 (41%), Gaps = 13/177 (7%)
Query: 107 VKNYQAHQSRVTMILFVLELEWVLSTGQDK-QFAWHCSESGQ---RLGGYRTSAVASGLQ 162
VK + H V F + + +L+ +D + W + SGQ RLGG+
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWE-TRSGQLLWRLGGHTGPVKFCRFS 72
Query: 163 FDVETRHVFIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHS 222
D H+F S T+ + + +GH V + + P R L SG D
Sbjct: 73 PD---GHLF-ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKR 128
Query: 223 VIMWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVERQETP 279
V++WD+ + + L GH D +Q+ ++ L + D + +W++ R TP
Sbjct: 129 VMLWDVQSGQMLRL-LVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL---RMVTP 181
>gi|30795182 zinc finger, FYVE domain containing 1 isoform 2 [Homo
sapiens]
Length = 362
Score = 52.8 bits (125), Expect = 6e-07
Identities = 53/176 (30%), Positives = 75/176 (42%), Gaps = 36/176 (20%)
Query: 184 LEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHND 243
+E NC +V R + G DPV V+ + V +W GT L+ +N+
Sbjct: 94 IECPNCGVVYRSRQYWFGNQ----DPVDTVVRT----EIVHVWP-----GTDGFLKDNNN 140
Query: 244 RVQAL----SYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDS----CQKCDQPFF 295
Q L ++ + +S G + W D Q P + +S C KC F
Sbjct: 141 AAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTD---QIAPAYWRPNSQILSCNKCATSFK 197
Query: 296 WNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGF-EFEVRVCDSCHEA 350
N D+K HHCR CG+ C CSSK +P G+ VRVCD+C+EA
Sbjct: 198 DN-----DTK------HHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEA 242
Score = 50.8 bits (120), Expect = 2e-06
Identities = 19/43 (44%), Positives = 29/43 (67%)
Query: 307 IGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHE 349
I L +HHCR CG+ C +CS R ++P G++ VRVC +C++
Sbjct: 315 IKLSKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNK 357
>gi|30795180 zinc finger, FYVE domain containing 1 isoform 1 [Homo
sapiens]
Length = 777
Score = 52.8 bits (125), Expect = 6e-07
Identities = 53/176 (30%), Positives = 75/176 (42%), Gaps = 36/176 (20%)
Query: 184 LEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHND 243
+E NC +V R + G DPV V+ + V +W GT L+ +N+
Sbjct: 509 IECPNCGVVYRSRQYWFGNQ----DPVDTVVRT----EIVHVWP-----GTDGFLKDNNN 555
Query: 244 RVQAL----SYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDS----CQKCDQPFF 295
Q L ++ + +S G + W D Q P + +S C KC F
Sbjct: 556 AAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTD---QIAPAYWRPNSQILSCNKCATSFK 612
Query: 296 WNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGF-EFEVRVCDSCHEA 350
N D+K HHCR CG+ C CSSK +P G+ VRVCD+C+EA
Sbjct: 613 DN-----DTK------HHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEA 657
Score = 50.8 bits (120), Expect = 2e-06
Identities = 19/43 (44%), Positives = 29/43 (67%)
Query: 307 IGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHE 349
I L +HHCR CG+ C +CS R ++P G++ VRVC +C++
Sbjct: 730 IKLSKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNK 772
>gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]
Length = 367
Score = 52.4 bits (124), Expect = 7e-07
Identities = 41/164 (25%), Positives = 71/164 (43%), Gaps = 16/164 (9%)
Query: 180 TILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQ 239
T++ + +V F+GH +T + P FS S D V+MWD+ G +L
Sbjct: 84 TVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLC 143
Query: 240 GHNDRVQALSYAQHTRQLISCGGDGGIVVWNM----DVERQETPEWLDSDSCQKCDQPFF 295
GH V L+ + + QL + D +++W++ VER + + C +P+
Sbjct: 144 GHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYI 203
Query: 296 WNFKQ-----MWDSKKIGL------RQHHCRKCGKAVCG-KCSS 327
+ +WDS+ + + +QH C +V G KC S
Sbjct: 204 LQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCIS 247
Score = 35.4 bits (80), Expect = 0.092
Identities = 29/122 (23%), Positives = 55/122 (45%), Gaps = 7/122 (5%)
Query: 16 LLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYWPSVY-HAMPSPCSCM 74
+++R +G + + +PK S S DR V +W S Q + HAM + +
Sbjct: 95 VVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAM--VVTGL 152
Query: 75 SFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFVLELEWVLSTGQ 134
+ +P++ +L G + T +L D V+ ++ VT + +V ++L T +
Sbjct: 153 AVSPDSSQLCTGSRDNT----LLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSE 208
Query: 135 DK 136
DK
Sbjct: 209 DK 210
Score = 31.6 bits (70), Expect = 1.3
Identities = 14/38 (36%), Positives = 23/38 (60%)
Query: 17 LQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKR 54
++R S+ VV VP+E ++ SED+T+R+W R
Sbjct: 181 VERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSR 218
>gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]
Length = 366
Score = 52.4 bits (124), Expect = 7e-07
Identities = 41/164 (25%), Positives = 71/164 (43%), Gaps = 16/164 (9%)
Query: 180 TILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQ 239
T++ + +V F+GH +T + P FS S D V+MWD+ G +L
Sbjct: 83 TVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLC 142
Query: 240 GHNDRVQALSYAQHTRQLISCGGDGGIVVWNM----DVERQETPEWLDSDSCQKCDQPFF 295
GH V L+ + + QL + D +++W++ VER + + C +P+
Sbjct: 143 GHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYI 202
Query: 296 WNFKQ-----MWDSKKIGL------RQHHCRKCGKAVCG-KCSS 327
+ +WDS+ + + +QH C +V G KC S
Sbjct: 203 LQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCIS 246
Score = 35.4 bits (80), Expect = 0.092
Identities = 29/122 (23%), Positives = 55/122 (45%), Gaps = 7/122 (5%)
Query: 16 LLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYWPSVY-HAMPSPCSCM 74
+++R +G + + +PK S S DR V +W S Q + HAM + +
Sbjct: 94 VVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAM--VVTGL 151
Query: 75 SFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFVLELEWVLSTGQ 134
+ +P++ +L G + T +L D V+ ++ VT + +V ++L T +
Sbjct: 152 AVSPDSSQLCTGSRDNT----LLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSE 207
Query: 135 DK 136
DK
Sbjct: 208 DK 209
Score = 31.6 bits (70), Expect = 1.3
Identities = 14/38 (36%), Positives = 23/38 (60%)
Query: 17 LQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKR 54
++R S+ VV VP+E ++ SED+T+R+W R
Sbjct: 180 VERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSR 217
>gi|13375827 phafin 2 [Homo sapiens]
Length = 249
Score = 52.4 bits (124), Expect = 7e-07
Identities = 22/48 (45%), Positives = 31/48 (64%), Gaps = 1/48 (2%)
Query: 310 RQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDEERA 357
R+HHCRKCG VCG CS KR +P + VR+CD C++ ++ + A
Sbjct: 171 RRHHCRKCGFVVCGPCSEKRFLLPSQSSK-PVRICDFCYDLLSAGDMA 217
>gi|31317270 WD repeat and FYVE domain containing 3 isoform 3 [Homo
sapiens]
Length = 281
Score = 52.4 bits (124), Expect = 7e-07
Identities = 32/119 (26%), Positives = 50/119 (42%), Gaps = 16/119 (13%)
Query: 241 HNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVE--RQETPEWLDS---DSCQKCDQPFF 295
H V AL ++ +++ G + W++ + R W+ DSC C F
Sbjct: 164 HPAEVTALGISKDHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRF- 222
Query: 296 WNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDE 354
+ R+HHCR CG+ C KCS +S I + VRVC +C+ + E
Sbjct: 223 ----------SLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHE 271
>gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 3526
Score = 52.4 bits (124), Expect = 7e-07
Identities = 32/119 (26%), Positives = 50/119 (42%), Gaps = 16/119 (13%)
Query: 241 HNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVE--RQETPEWLDS---DSCQKCDQPFF 295
H V AL ++ +++ G + W++ + R W+ DSC C F
Sbjct: 3409 HPAEVTALGISKDHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRF- 3467
Query: 296 WNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDE 354
+ R+HHCR CG+ C KCS +S I + VRVC +C+ + E
Sbjct: 3468 ----------SLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHE 3516
Score = 50.8 bits (120), Expect = 2e-06
Identities = 47/189 (24%), Positives = 81/189 (42%), Gaps = 22/189 (11%)
Query: 104 MTPVKNYQAHQSRVTM----ILFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVAS 159
+TPVK + ++ IL V + + ++ +K FAW ++ RLG Y + +
Sbjct: 3012 LTPVKELKEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAMT 3071
Query: 160 GLQFDVE-----------TRHVFIGDHSGQVTILKL-----EQENCTLVTTFRGHTGGVT 203
+ E + V G S V + ++ + + TL GHT VT
Sbjct: 3072 VYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTLKQALLGHTDTVT 3131
Query: 204 ALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGD 263
++ SGS D + I+WD+ + +L+GH V AL + T ++SC G
Sbjct: 3132 CATASLAYHIIVSGSRDRTCIIWDL-NKLSFLTQLRGHRAPVSALCINELTGDIVSCAGT 3190
Query: 264 GGIVVWNMD 272
I VW+++
Sbjct: 3191 -YIHVWSIN 3198
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 52.4 bits (124), Expect = 7e-07
Identities = 49/196 (25%), Positives = 88/196 (44%), Gaps = 17/196 (8%)
Query: 38 GVISVSEDRTVRVWLKRDSGQYWPSV-YHAMPSPCSCMSFNPETRRLSIGLDNGTISEFI 96
G++S SED ++R W D G + +V Y P + +P + + G + T +
Sbjct: 356 GLLSCSEDMSIRYW---DLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWS 412
Query: 97 LSEDYNKMTPVKNYQAHQSRVTMILFVLELEWVLSTGQDKQFAWHCSESGQRLG---GYR 153
Y P++ Y H + V + F ++ + DK ++ G + G+R
Sbjct: 413 FDRTY----PLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHR 468
Query: 154 TSAVASGLQFDVETRHVFIGDHSGQVTILKL-EQENCTLVTTFRGHTGGVTALCWDPVQR 212
++ L F +++ +G+ LKL + + TL RGHT +T+L + P
Sbjct: 469 GPVLS--LAFSPNGKYLA---SAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSG 523
Query: 213 VLFSGSSDHSVIMWDI 228
++ S S D+SV +WDI
Sbjct: 524 LIASASMDNSVRVWDI 539
>gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo
sapiens]
Length = 475
Score = 51.6 bits (122), Expect = 1e-06
Identities = 45/185 (24%), Positives = 80/185 (43%), Gaps = 21/185 (11%)
Query: 107 VKNYQAHQSRVTMILFVLELEWVLSTGQDKQFAWHCSESGQRLG--------------GY 152
++ + HQ +T ++ + + S +D ESG++L G+
Sbjct: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
Query: 153 RTSAVASGLQFDVETRHVFIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQR 212
+ + + D +++ GD S + I E ++C + TF GH V+ L +
Sbjct: 199 SSHVLCMAISSD--GKYLASGDRSKLILIW--EAQSCQHLYTFTGHRDAVSGLAFRRGTH 254
Query: 213 VLFSGSSDHSVIMWDIGGRKGTAIE-LQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNM 271
L+S S D SV +W++ + + +E L GH D V AL + + G DG + VW +
Sbjct: 255 QLYSTSHDRSVKVWNVA--ENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKI 312
Query: 272 DVERQ 276
E Q
Sbjct: 313 PEESQ 317
Score = 47.4 bits (111), Expect = 2e-05
Identities = 50/240 (20%), Positives = 103/240 (42%), Gaps = 28/240 (11%)
Query: 20 MEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYWPSVYHAMP----------S 69
+ G Q + V+ P + + S ++D ++ W +SG+ + A S
Sbjct: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKW-SVESGRKLHVIPRAKKGAEGKPPGHSS 200
Query: 70 PCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFVLELEWV 129
CM+ + + + L+ +G S+ IL + + + H+ V+ + F +
Sbjct: 201 HVLCMAISSDGKYLA----SGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256
Query: 130 LSTGQDKQF-AWHCSESG--QRLGGYRTSAVASGLQFDVETRH--VFIGDHSGQVTILKL 184
ST D+ W+ +E+ + L G++ + A D +R V G G V + K+
Sbjct: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAA----LDALSRECCVTAGGRDGTVRVWKI 312
Query: 185 EQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDR 244
+E+ + F GH G + + + ++ SG+ D SV +W + ++ A++ + H R
Sbjct: 313 PEESQLV---FYGHQGSIDCIHLINEEHMV-SGADDGSVALWGLSKKRPLALQREAHGLR 368
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 51.2 bits (121), Expect = 2e-06
Identities = 32/102 (31%), Positives = 53/102 (51%), Gaps = 7/102 (6%)
Query: 171 FIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGG 230
+I SG TI C V T GH G+ L + R++ SGSSD+++ +WDI
Sbjct: 402 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDI-- 457
Query: 231 RKGTAIE-LQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNM 271
G + L+GH + V+ + + ++++S DG I VW++
Sbjct: 458 ECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 497
Score = 45.8 bits (107), Expect = 7e-05
Identities = 45/168 (26%), Positives = 70/168 (41%), Gaps = 23/168 (13%)
Query: 106 PVKNYQAHQSRVTMILFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDV 165
P Y+A ++ + +E W G+ HC TS LQ+D
Sbjct: 228 PNSFYRALYPKIIQDIETIESNW--RCGRHSLQRIHCRSE--------TSKGVYCLQYD- 276
Query: 166 ETRHVFIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIM 225
+ + G + I C + T GHTG V L +D +RV+ +GSSD +V +
Sbjct: 277 -DQKIVSGLRDNTIKIWDKNTLECKRILT--GHTGSVLCLQYD--ERVIITGSSDSTVRV 331
Query: 226 WDI--GGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNM 271
WD+ G T I H + V L + + +++C D I VW+M
Sbjct: 332 WDVNTGEMLNTLIH---HCEAVLHLRF--NNGMMVTCSKDRSIAVWDM 374
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 51.2 bits (121), Expect = 2e-06
Identities = 32/102 (31%), Positives = 53/102 (51%), Gaps = 7/102 (6%)
Query: 171 FIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGG 230
+I SG TI C V T GH G+ L + R++ SGSSD+++ +WDI
Sbjct: 438 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDI-- 493
Query: 231 RKGTAIE-LQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNM 271
G + L+GH + V+ + + ++++S DG I VW++
Sbjct: 494 ECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 533
Score = 45.8 bits (107), Expect = 7e-05
Identities = 45/168 (26%), Positives = 70/168 (41%), Gaps = 23/168 (13%)
Query: 106 PVKNYQAHQSRVTMILFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDV 165
P Y+A ++ + +E W G+ HC TS LQ+D
Sbjct: 264 PNSFYRALYPKIIQDIETIESNW--RCGRHSLQRIHCRSE--------TSKGVYCLQYD- 312
Query: 166 ETRHVFIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIM 225
+ + G + I C + T GHTG V L +D +RV+ +GSSD +V +
Sbjct: 313 -DQKIVSGLRDNTIKIWDKNTLECKRILT--GHTGSVLCLQYD--ERVIITGSSDSTVRV 367
Query: 226 WDI--GGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNM 271
WD+ G T I H + V L + + +++C D I VW+M
Sbjct: 368 WDVNTGEMLNTLIH---HCEAVLHLRF--NNGMMVTCSKDRSIAVWDM 410
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 51.2 bits (121), Expect = 2e-06
Identities = 32/102 (31%), Positives = 53/102 (51%), Gaps = 7/102 (6%)
Query: 171 FIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGG 230
+I SG TI C V T GH G+ L + R++ SGSSD+++ +WDI
Sbjct: 375 YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDI-- 430
Query: 231 RKGTAIE-LQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNM 271
G + L+GH + V+ + + ++++S DG I VW++
Sbjct: 431 ECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 470
Score = 48.5 bits (114), Expect = 1e-05
Identities = 37/112 (33%), Positives = 55/112 (49%), Gaps = 11/112 (9%)
Query: 161 LQFDVETRHVFIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSD 220
LQ+D E + G + I C V T GHTG V L +D +RV+ +GSSD
Sbjct: 246 LQYDDEK--IISGLRDNSIKIWDKTSLECLKVLT--GHTGSVLCLQYD--ERVIVTGSSD 299
Query: 221 HSVIMWDIGGRKGTAIE-LQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNM 271
+V +WD+ G + L HN+ V L ++ +++C D I VW+M
Sbjct: 300 STVRVWDV--NTGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDM 347
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,136,780
Number of Sequences: 37866
Number of extensions: 739702
Number of successful extensions: 4669
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 196
Number of HSP's successfully gapped in prelim test: 181
Number of HSP's that attempted gapping in prelim test: 2968
Number of HSP's gapped (non-prelim): 1593
length of query: 400
length of database: 18,247,518
effective HSP length: 104
effective length of query: 296
effective length of database: 14,309,454
effective search space: 4235598384
effective search space used: 4235598384
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.