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Search of human proteins with 16418431
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16418431 nitric oxide synthase trafficker isoform 1 [Homo
sapiens]
(428 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo sap... 847 0.0
gi|16418431 nitric oxide synthase trafficker isoform 1 [Homo sap... 847 0.0
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 83 4e-16
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 76 5e-14
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 76 5e-14
gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens] 69 6e-12
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 69 8e-12
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 69 8e-12
gi|11321634 CD2-associated protein [Homo sapiens] 65 1e-10
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 65 2e-10
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 64 2e-10
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 64 2e-10
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 62 1e-09
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 60 5e-09
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 59 6e-09
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 59 6e-09
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 59 6e-09
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo... 59 6e-09
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ... 59 6e-09
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 59 6e-09
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 59 8e-09
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 59 1e-08
gi|55956916 myosin IE [Homo sapiens] 59 1e-08
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 58 1e-08
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 58 1e-08
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 58 1e-08
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 57 3e-08
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 57 4e-08
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 57 4e-08
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 56 7e-08
>gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo
sapiens]
Length = 506
Score = 847 bits (2187), Expect = 0.0
Identities = 428/428 (100%), Positives = 428/428 (100%)
Query: 1 MKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNWNQQIKAKK 60
MKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNWNQQIKAKK
Sbjct: 79 MKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNWNQQIKAKK 138
Query: 61 KLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEKEDENYYQKNMAGYSTR 120
KLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEKEDENYYQKNMAGYSTR
Sbjct: 139 KLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEKEDENYYQKNMAGYSTR 198
Query: 121 LKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKIDIE 180
LKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKIDIE
Sbjct: 199 LKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKIDIE 258
Query: 181 KDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRLQRDIEKASK 240
KDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRLQRDIEKASK
Sbjct: 259 KDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRLQRDIEKASK 318
Query: 241 DKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELEQRPQ 300
DKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELEQRPQ
Sbjct: 319 DKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELEQRPQ 378
Query: 301 PSHPCSNSIFRWREKEHTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQL 360
PSHPCSNSIFRWREKEHTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQL
Sbjct: 379 PSHPCSNSIFRWREKEHTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQL 438
Query: 361 SSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSN 420
SSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSN
Sbjct: 439 SSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSN 498
Query: 421 AGNTATKA 428
AGNTATKA
Sbjct: 499 AGNTATKA 506
>gi|16418431 nitric oxide synthase trafficker isoform 1 [Homo
sapiens]
Length = 428
Score = 847 bits (2187), Expect = 0.0
Identities = 428/428 (100%), Positives = 428/428 (100%)
Query: 1 MKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNWNQQIKAKK 60
MKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNWNQQIKAKK
Sbjct: 1 MKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNWNQQIKAKK 60
Query: 61 KLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEKEDENYYQKNMAGYSTR 120
KLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEKEDENYYQKNMAGYSTR
Sbjct: 61 KLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEKEDENYYQKNMAGYSTR 120
Query: 121 LKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKIDIE 180
LKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKIDIE
Sbjct: 121 LKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKIDIE 180
Query: 181 KDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRLQRDIEKASK 240
KDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRLQRDIEKASK
Sbjct: 181 KDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRLQRDIEKASK 240
Query: 241 DKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELEQRPQ 300
DKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELEQRPQ
Sbjct: 241 DKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELEQRPQ 300
Query: 301 PSHPCSNSIFRWREKEHTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQL 360
PSHPCSNSIFRWREKEHTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQL
Sbjct: 301 PSHPCSNSIFRWREKEHTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQL 360
Query: 361 SSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSN 420
SSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSN
Sbjct: 361 SSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSN 420
Query: 421 AGNTATKA 428
AGNTATKA
Sbjct: 421 AGNTATKA 428
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 83.2 bits (204), Expect = 4e-16
Identities = 98/436 (22%), Positives = 184/436 (42%), Gaps = 39/436 (8%)
Query: 15 IELEAIKPTYQVLNVQEKKRKSLDNEVE---KTANLVISNWNQQIKAKKKLMVSTKKHEA 71
+ELE + +E +RK+ + E K L W +Q++ +K+L +K
Sbjct: 376 MELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRL----EKQRE 431
Query: 72 LFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEK----EDENYYQKNMAGYSTRLKWENTL 127
L + E+E+RK + + + ++LE+ E E ++ + R + E
Sbjct: 432 L--------ERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVR 483
Query: 128 ENCYQSILELEKERIQLLCNNLNQYSQHISLFGQT----LTTCHTQIHCAISKI-DIEKD 182
N + L LE E + ++ Q + L QT L Q I +I ++++
Sbjct: 484 LNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQE 543
Query: 183 IQAVMEETAILSTENK--SEFLLTDYFEEDPNSAMDKERRKSLLKPKLL-RLQRDIEKAS 239
+Q + L E + +E + F P+S + +KSL K +L RL+ ++ +
Sbjct: 544 LQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD--A 601
Query: 240 KDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDEN--NLKLDLLEANSYKLSSMLAELEQ 297
+KE ++ + S + + + +T L E +K D L+ K ++ + +
Sbjct: 602 LEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKL 661
Query: 298 RPQPSHPCSNSIFR-WRE---KEHTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTP 353
+ + W+E KE ++ ++++ KA + + +
Sbjct: 662 EDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKA 721
Query: 354 APGAAQLSSRLC--KALYSFQARQDDELNLEKGDIVIIHEKK--EEGWWFGSLNGKKGHF 409
+ +S L +ALY F+AR DE++ GDI+ + EK E GW +GS G G F
Sbjct: 722 EEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWF 781
Query: 410 PAAYVEELPSNAGNTA 425
P YVE++PS+ A
Sbjct: 782 PCNYVEKMPSSENEKA 797
Score = 62.8 bits (151), Expect = 6e-10
Identities = 30/75 (40%), Positives = 49/75 (65%), Gaps = 2/75 (2%)
Query: 347 NPGSSTPAPGAAQLSSRL-CKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGK 405
+PGS +P G Q+ L +AL S+ A++D+ LN K DI+ + E+ +E WWFG ++G
Sbjct: 857 SPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGG 915
Query: 406 KGHFPAAYVEELPSN 420
+G FP +YV+ +P +
Sbjct: 916 RGWFPKSYVKIIPGS 930
Score = 50.1 bits (118), Expect = 4e-06
Identities = 19/49 (38%), Positives = 30/49 (61%)
Query: 367 ALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVE 415
A+Y + A +DEL+ KG ++ + K + WW G +NG G FP+ YV+
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1155
Score = 46.6 bits (109), Expect = 4e-05
Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 12/82 (14%)
Query: 341 SSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFG 400
S G S G+S P AQ++S ++ A ++L+L G +++I +K GWW G
Sbjct: 1014 SFGSASKSGASNKKPEIAQVTS-------AYVASGSEQLSLAPGQLILILKKNTSGWWQG 1066
Query: 401 SLNGK-----KGHFPAAYVEEL 417
L + KG FPA++V+ L
Sbjct: 1067 ELQARGKKRQKGWFPASHVKLL 1088
Score = 44.7 bits (104), Expect = 2e-04
Identities = 88/452 (19%), Positives = 176/452 (38%), Gaps = 77/452 (17%)
Query: 31 EKKRKSLDNEVEKTANLV--ISNWNQQIKAKKKLMVSTKKHEALFQLVESSKQSMTEKEK 88
++ ++ LD ++TA+ + + ++N Q+K ++ + AL QL + + + E E+
Sbjct: 593 QRLKEQLDALEKETASKLSEMDSFNNQLKELRETY--NTQQLALEQLYKIKRDKLKEIER 650
Query: 89 RKLLNKLTKSTE-----KLEKEDENYYQKNMAGYST----RLKWENTLENCYQSILELE- 138
++L K E K ++ EN +++N+ RL+ E T E + + E
Sbjct: 651 KRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEE 710
Query: 139 ---KERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKID---IEKDIQAVMEETAI 192
K++ L + + + + + L + H +S I+ D + V E +
Sbjct: 711 KQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWL 770
Query: 193 L-STENKSEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRLQRDIEKASKDKEGLERMLKT 251
S + + +Y E+ P+S + EKA K+ L +
Sbjct: 771 YGSFQGNFGWFPCNYVEKMPSS--------------------ENEKAVSPKKALLPPTVS 810
Query: 252 YSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELEQRPQPSHPC------ 305
S+TS+ S+ S A++ D N+ L N+ P P
Sbjct: 811 LSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQV 870
Query: 306 -----SNSIFRWREKEHTH-SYVKISRPFLMKRLENIVSKASSGGQS---------NPGS 350
+ ++ W K+ H ++ K ++++ EN GG+ PGS
Sbjct: 871 VENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGS 930
Query: 351 STPAPGAAQLSSRLCK--------------ALYSFQARQDDELNLEKGDIVIIHEKKEEG 396
L + + K ALY + + + +L +G+ +++ +K E
Sbjct: 931 EVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGE- 989
Query: 397 WWFGSLNGKKGHFPAAYVEELPSNAGNTATKA 428
WW GS+ + G FP+ YV+ + +A+K+
Sbjct: 990 WWTGSIGDRSGIFPSNYVKPKDQESFGSASKS 1021
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 76.3 bits (186), Expect = 5e-14
Identities = 103/461 (22%), Positives = 186/461 (40%), Gaps = 62/461 (13%)
Query: 15 IELEAIKPTYQVLNVQEKKRKSLDNEVE---KTANLVISNWNQQIKAKKKLMVSTKKHEA 71
+ELE + +E +RK+ + E K L W +Q++ +K+L +K
Sbjct: 376 MELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRL----EKQRE 431
Query: 72 LFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEK----EDENYYQKNMAGYSTRLKWENTL 127
L + E+E+RK + + + ++LE+ E E ++ + R + E
Sbjct: 432 L--------ERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVR 483
Query: 128 ENCYQSILELEKERIQLLCNNLNQYSQHISLFGQT----LTTCHTQIHCAISKI-DIEKD 182
N + L LE E + ++ Q + L QT L Q I +I ++++
Sbjct: 484 LNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQE 543
Query: 183 IQAVMEETAILSTENK--SEFLLTDYFEEDPNSAMDKERRKSLLKPKLL-RLQRDIEKAS 239
+Q + L E + +E + F P+S + +KSL K +L RL+ ++
Sbjct: 544 LQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALE 603
Query: 240 KDKEGLERMLKTYSST---SSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLA--- 293
K+ + ++++ + D+ Q + L NNL L L E + LA
Sbjct: 604 KETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQ 663
Query: 294 -----------------ELEQRPQPSHPCSNSIFR-----WRE---KEHTHSYVKISRPF 328
EL Q+ + + + W+E KE ++
Sbjct: 664 LYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEK 723
Query: 329 LMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLC--KALYSFQARQDDELNLEKGDI 386
++++ KA + + + + +S L +ALY F+AR DE++ GDI
Sbjct: 724 TQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDI 783
Query: 387 VIIHEKK--EEGWWFGSLNGKKGHFPAAYVEELPSNAGNTA 425
+ + EK E GW +GS G G FP YVE++PS+ A
Sbjct: 784 IQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKA 824
Score = 62.8 bits (151), Expect = 6e-10
Identities = 30/75 (40%), Positives = 49/75 (65%), Gaps = 2/75 (2%)
Query: 347 NPGSSTPAPGAAQLSSRL-CKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGK 405
+PGS +P G Q+ L +AL S+ A++D+ LN K DI+ + E+ +E WWFG ++G
Sbjct: 884 SPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGG 942
Query: 406 KGHFPAAYVEELPSN 420
+G FP +YV+ +P +
Sbjct: 943 RGWFPKSYVKIIPGS 957
Score = 50.1 bits (118), Expect = 4e-06
Identities = 19/49 (38%), Positives = 30/49 (61%)
Query: 367 ALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVE 415
A+Y + A +DEL+ KG ++ + K + WW G +NG G FP+ YV+
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
Score = 46.6 bits (109), Expect = 4e-05
Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 12/82 (14%)
Query: 341 SSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFG 400
S G S G+S P AQ++S ++ A ++L+L G +++I +K GWW G
Sbjct: 1041 SFGSASKSGASNKKPEIAQVTS-------AYVASGSEQLSLAPGQLILILKKNTSGWWQG 1093
Query: 401 SLNGK-----KGHFPAAYVEEL 417
L + KG FPA++V+ L
Sbjct: 1094 ELQARGKKRQKGWFPASHVKLL 1115
Score = 43.5 bits (101), Expect = 4e-04
Identities = 48/228 (21%), Positives = 88/228 (38%), Gaps = 36/228 (15%)
Query: 236 EKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAEL 295
EKA K+ L + S+TS+ S+ S A++ D N+ L N+
Sbjct: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
Query: 296 EQRPQPSHPC-----------SNSIFRWREKEHTH-SYVKISRPFLMKRLENIVSKASSG 343
P P + ++ W K+ H ++ K ++++ EN G
Sbjct: 882 TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHG 941
Query: 344 GQS---------NPGSSTPAPGAAQLSSRLCK--------------ALYSFQARQDDELN 380
G+ PGS L + + K ALY + + + +L
Sbjct: 942 GRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLT 1001
Query: 381 LEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSNAGNTATKA 428
+G+ +++ +K E WW GS+ + G FP+ YV+ + +A+K+
Sbjct: 1002 FTEGEEILVTQKDGE-WWTGSIGDRSGIFPSNYVKPKDQESFGSASKS 1048
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 76.3 bits (186), Expect = 5e-14
Identities = 103/461 (22%), Positives = 186/461 (40%), Gaps = 62/461 (13%)
Query: 15 IELEAIKPTYQVLNVQEKKRKSLDNEVE---KTANLVISNWNQQIKAKKKLMVSTKKHEA 71
+ELE + +E +RK+ + E K L W +Q++ +K+L +K
Sbjct: 376 MELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRL----EKQRE 431
Query: 72 LFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEK----EDENYYQKNMAGYSTRLKWENTL 127
L + E+E+RK + + + ++LE+ E E ++ + R + E
Sbjct: 432 L--------ERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVR 483
Query: 128 ENCYQSILELEKERIQLLCNNLNQYSQHISLFGQT----LTTCHTQIHCAISKI-DIEKD 182
N + L LE E + ++ Q + L QT L Q I +I ++++
Sbjct: 484 LNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQE 543
Query: 183 IQAVMEETAILSTENK--SEFLLTDYFEEDPNSAMDKERRKSLLKPKLL-RLQRDIEKAS 239
+Q + L E + +E + F P+S + +KSL K +L RL+ ++
Sbjct: 544 LQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALE 603
Query: 240 KDKEGLERMLKTYSST---SSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLA--- 293
K+ + ++++ + D+ Q + L NNL L L E + LA
Sbjct: 604 KETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQ 663
Query: 294 -----------------ELEQRPQPSHPCSNSIFR-----WRE---KEHTHSYVKISRPF 328
EL Q+ + + + W+E KE ++
Sbjct: 664 LYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEK 723
Query: 329 LMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLC--KALYSFQARQDDELNLEKGDI 386
++++ KA + + + + +S L +ALY F+AR DE++ GDI
Sbjct: 724 TQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDI 783
Query: 387 VIIHEKK--EEGWWFGSLNGKKGHFPAAYVEELPSNAGNTA 425
+ + EK E GW +GS G G FP YVE++PS+ A
Sbjct: 784 IQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKA 824
Score = 62.8 bits (151), Expect = 6e-10
Identities = 30/75 (40%), Positives = 49/75 (65%), Gaps = 2/75 (2%)
Query: 347 NPGSSTPAPGAAQLSSRL-CKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGK 405
+PGS +P G Q+ L +AL S+ A++D+ LN K DI+ + E+ +E WWFG ++G
Sbjct: 884 SPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGG 942
Query: 406 KGHFPAAYVEELPSN 420
+G FP +YV+ +P +
Sbjct: 943 RGWFPKSYVKIIPGS 957
Score = 50.1 bits (118), Expect = 4e-06
Identities = 19/49 (38%), Positives = 30/49 (61%)
Query: 367 ALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVE 415
A+Y + A +DEL+ KG ++ + K + WW G +NG G FP+ YV+
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
Score = 46.6 bits (109), Expect = 4e-05
Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 12/82 (14%)
Query: 341 SSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFG 400
S G S G+S P AQ++S ++ A ++L+L G +++I +K GWW G
Sbjct: 1041 SFGSASKSGASNKKPEIAQVTS-------AYVASGSEQLSLAPGQLILILKKNTSGWWQG 1093
Query: 401 SLNGK-----KGHFPAAYVEEL 417
L + KG FPA++V+ L
Sbjct: 1094 ELQARGKKRQKGWFPASHVKLL 1115
Score = 43.5 bits (101), Expect = 4e-04
Identities = 48/228 (21%), Positives = 88/228 (38%), Gaps = 36/228 (15%)
Query: 236 EKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAEL 295
EKA K+ L + S+TS+ S+ S A++ D N+ L N+
Sbjct: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
Query: 296 EQRPQPSHPC-----------SNSIFRWREKEHTH-SYVKISRPFLMKRLENIVSKASSG 343
P P + ++ W K+ H ++ K ++++ EN G
Sbjct: 882 TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHG 941
Query: 344 GQS---------NPGSSTPAPGAAQLSSRLCK--------------ALYSFQARQDDELN 380
G+ PGS L + + K ALY + + + +L
Sbjct: 942 GRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLT 1001
Query: 381 LEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSNAGNTATKA 428
+G+ +++ +K E WW GS+ + G FP+ YV+ + +A+K+
Sbjct: 1002 FTEGEEILVTQKDGE-WWTGSIGDRSGIFPSNYVKPKDQESFGSASKS 1048
>gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]
Length = 368
Score = 69.3 bits (168), Expect = 6e-12
Identities = 52/202 (25%), Positives = 88/202 (43%), Gaps = 10/202 (4%)
Query: 217 KERRKSLLKPKLLRLQRDIEKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNL 276
K++R+ + + LR + +EK + KE E + T ++ A +D +
Sbjct: 171 KKKRQGKIPDEELR--QALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQ 228
Query: 277 KLDLLEANSYKLSSMLAELEQRPQPSH-PCSNSIFRWREKEHTHSYVKISRPFLMKRLEN 335
+ +L+ + KL + E RP+ + P F E E ++ F
Sbjct: 229 AVQILDELAEKLKRRMREASSRPKREYKPKPREPFDLGEPEQSNG------GFPCTTAPK 282
Query: 336 IVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEE 395
I + +S P TP+ L CKALY F+ D EL +GD++ + + +E
Sbjct: 283 IAASSSFRSSDKP-IRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDE 341
Query: 396 GWWFGSLNGKKGHFPAAYVEEL 417
W+ G L+G+ G FP +YVE L
Sbjct: 342 NWYEGMLDGQSGFFPLSYVEVL 363
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 68.9 bits (167), Expect = 8e-12
Identities = 102/452 (22%), Positives = 187/452 (41%), Gaps = 81/452 (17%)
Query: 2 KSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNW--------- 52
K +L ++L K ELE + + ++ +R++ E+E+ L W
Sbjct: 404 KRQLELEKQLEKQRELERQREEERRKEIE--RREAAKRELERQRQL---EWERNRRQELL 458
Query: 53 NQQIKAKKKLMVSTKKHEAL-FQLVE-SSKQSMTEKEKRKLLNKLTKSTEKLEKEDENYY 110
NQ+ K ++ ++V K + L F+L + K+ E + + + +LT T++ E E N
Sbjct: 459 NQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLT--TQRQEIESTNKS 516
Query: 111 QKNMAGYSTRLKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQI 170
++ T L+ + L+ Q + L E+ Q+L + L Q Q+ SL +L T +
Sbjct: 517 RELRIAEITHLQQQ--LQESQQMLGRLIPEK-QILNDQLKQVQQN-SLHRDSLVTLKRAL 572
Query: 171 --------HCAISKIDIEKDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKS 222
H ++EK+ ++ ++E I + + K + + + +M+ ER K
Sbjct: 573 EAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQ 632
Query: 223 LLKP-KLLRLQRDIEKASK-----DKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNL 276
+ K++ L++ E+A + DK+ LE + + K ++ +E+
Sbjct: 633 KEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQ---EDEHQRPRKLHEEEKLKREESVK 689
Query: 277 KLDLLEANSYKLSSMLAEL-EQRPQPSHPCSNSIFRWREKEHTHSYVKISRPFLMKRLEN 335
K D E + L L Q +P+ P + + EK P + EN
Sbjct: 690 KKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKG----------PLTISAQEN 739
Query: 336 IVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIH----- 390
+ +ALY F++R DE+ ++ GDIV++
Sbjct: 740 V------------------------KVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVD 775
Query: 391 --EKKEEGWWFGSLNGKKGHFPAAYVEELPSN 420
+ E GW G L GK G FPA Y E++P N
Sbjct: 776 ESQTGEPGWLGGELKGKTGWFPANYAEKIPEN 807
Score = 55.5 bits (132), Expect = 9e-08
Identities = 25/68 (36%), Positives = 44/68 (64%), Gaps = 4/68 (5%)
Query: 351 STPAPGAAQ---LSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKG 407
S+P+P Q + +ALY ++A++D+ LN K D++ + E+++ WWFG + G+KG
Sbjct: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKG 959
Query: 408 HFPAAYVE 415
FP +YV+
Sbjct: 960 WFPKSYVK 967
Score = 53.1 bits (126), Expect = 5e-07
Identities = 26/74 (35%), Positives = 40/74 (54%), Gaps = 5/74 (6%)
Query: 347 NPGSSTPAPGAAQLSSRLCKA-----LYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGS 401
+PG+S P S+ L +Y + A+ DDEL KG I+ + K++ WW G
Sbjct: 1137 SPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGE 1196
Query: 402 LNGKKGHFPAAYVE 415
+NG+ G FP+ YV+
Sbjct: 1197 VNGQVGLFPSNYVK 1210
Score = 50.4 bits (119), Expect = 3e-06
Identities = 32/111 (28%), Positives = 55/111 (49%), Gaps = 9/111 (8%)
Query: 320 SYVKISRPFLMKRLENIVSKASSGGQSNPGS--STPAPGAAQL-SSRLCKALYSFQARQD 376
SYVK+ + K + SG +P S +P A + S A+Y++++ +
Sbjct: 964 SYVKLISGPIRKS-----TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQ 1018
Query: 377 DELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSNAGNTATK 427
+L ++GD++++ KK+ WW G++ K G FP+ YV S TA K
Sbjct: 1019 GDLTFQQGDVILV-TKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGK 1068
Score = 43.5 bits (101), Expect = 4e-04
Identities = 31/99 (31%), Positives = 46/99 (46%), Gaps = 10/99 (10%)
Query: 335 NIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKE 394
N V S G G + G+ + + + S+ A ++L L G +++I +K
Sbjct: 1053 NYVRLKDSEGSGTAGKT----GSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNP 1108
Query: 395 EGWWFGSL--NGKK---GHFPAAYVEEL-PSNAGNTATK 427
GWW G L GKK G FPA YV+ L P + T T+
Sbjct: 1109 GGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTE 1147
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 68.9 bits (167), Expect = 8e-12
Identities = 102/452 (22%), Positives = 187/452 (41%), Gaps = 81/452 (17%)
Query: 2 KSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNW--------- 52
K +L ++L K ELE + + ++ +R++ E+E+ L W
Sbjct: 404 KRQLELEKQLEKQRELERQREEERRKEIE--RREAAKRELERQRQL---EWERNRRQELL 458
Query: 53 NQQIKAKKKLMVSTKKHEAL-FQLVE-SSKQSMTEKEKRKLLNKLTKSTEKLEKEDENYY 110
NQ+ K ++ ++V K + L F+L + K+ E + + + +LT T++ E E N
Sbjct: 459 NQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLT--TQRQEIESTNKS 516
Query: 111 QKNMAGYSTRLKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQI 170
++ T L+ + L+ Q + L E+ Q+L + L Q Q+ SL +L T +
Sbjct: 517 RELRIAEITHLQQQ--LQESQQMLGRLIPEK-QILNDQLKQVQQN-SLHRDSLVTLKRAL 572
Query: 171 --------HCAISKIDIEKDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKS 222
H ++EK+ ++ ++E I + + K + + + +M+ ER K
Sbjct: 573 EAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQ 632
Query: 223 LLKP-KLLRLQRDIEKASK-----DKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNL 276
+ K++ L++ E+A + DK+ LE + + K ++ +E+
Sbjct: 633 KEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQ---EDEHQRPRKLHEEEKLKREESVK 689
Query: 277 KLDLLEANSYKLSSMLAEL-EQRPQPSHPCSNSIFRWREKEHTHSYVKISRPFLMKRLEN 335
K D E + L L Q +P+ P + + EK P + EN
Sbjct: 690 KKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKG----------PLTISAQEN 739
Query: 336 IVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIH----- 390
+ +ALY F++R DE+ ++ GDIV++
Sbjct: 740 V------------------------KVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVD 775
Query: 391 --EKKEEGWWFGSLNGKKGHFPAAYVEELPSN 420
+ E GW G L GK G FPA Y E++P N
Sbjct: 776 ESQTGEPGWLGGELKGKTGWFPANYAEKIPEN 807
Score = 55.5 bits (132), Expect = 9e-08
Identities = 25/68 (36%), Positives = 44/68 (64%), Gaps = 4/68 (5%)
Query: 351 STPAPGAAQ---LSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKG 407
S+P+P Q + +ALY ++A++D+ LN K D++ + E+++ WWFG + G+KG
Sbjct: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKG 959
Query: 408 HFPAAYVE 415
FP +YV+
Sbjct: 960 WFPKSYVK 967
Score = 53.1 bits (126), Expect = 5e-07
Identities = 26/74 (35%), Positives = 40/74 (54%), Gaps = 5/74 (6%)
Query: 347 NPGSSTPAPGAAQLSSRLCKA-----LYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGS 401
+PG+S P S+ L +Y + A+ DDEL KG I+ + K++ WW G
Sbjct: 1137 SPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGE 1196
Query: 402 LNGKKGHFPAAYVE 415
+NG+ G FP+ YV+
Sbjct: 1197 VNGQVGLFPSNYVK 1210
Score = 50.4 bits (119), Expect = 3e-06
Identities = 32/111 (28%), Positives = 55/111 (49%), Gaps = 9/111 (8%)
Query: 320 SYVKISRPFLMKRLENIVSKASSGGQSNPGS--STPAPGAAQL-SSRLCKALYSFQARQD 376
SYVK+ + K + SG +P S +P A + S A+Y++++ +
Sbjct: 964 SYVKLISGPIRKS-----TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQ 1018
Query: 377 DELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSNAGNTATK 427
+L ++GD++++ KK+ WW G++ K G FP+ YV S TA K
Sbjct: 1019 GDLTFQQGDVILV-TKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGK 1068
Score = 43.5 bits (101), Expect = 4e-04
Identities = 31/99 (31%), Positives = 46/99 (46%), Gaps = 10/99 (10%)
Query: 335 NIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKE 394
N V S G G + G+ + + + S+ A ++L L G +++I +K
Sbjct: 1053 NYVRLKDSEGSGTAGKT----GSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNP 1108
Query: 395 EGWWFGSL--NGKK---GHFPAAYVEEL-PSNAGNTATK 427
GWW G L GKK G FPA YV+ L P + T T+
Sbjct: 1109 GGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTE 1147
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 65.1 bits (157), Expect = 1e-10
Identities = 28/55 (50%), Positives = 40/55 (72%)
Query: 363 RLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 417
R CK L+ + + +DEL L+ GDI+ I+E+ EEGWW G+LN K G FP+ +V+EL
Sbjct: 111 RQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKEL 165
Score = 51.2 bits (121), Expect = 2e-06
Identities = 21/55 (38%), Positives = 35/55 (63%), Gaps = 2/55 (3%)
Query: 365 CKALYSFQARQDDELNLEKGDIV--IIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 417
C+ L++++ +DEL ++G+I+ I E E GWW G LNGK+G FP + ++
Sbjct: 274 CRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
Score = 47.0 bits (110), Expect = 3e-05
Identities = 21/50 (42%), Positives = 33/50 (66%), Gaps = 1/50 (2%)
Query: 369 YSFQARQDDELNLEKGDIVI-IHEKKEEGWWFGSLNGKKGHFPAAYVEEL 417
Y + A DDEL + G+I+ + + +EEGW G LNG++G FP +V+E+
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEI 57
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 64.7 bits (156), Expect = 2e-10
Identities = 31/80 (38%), Positives = 45/80 (56%), Gaps = 2/80 (2%)
Query: 338 SKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGW 397
S +GG S+ G TP P Q+ C+ALY F+ + EL ++GDI+ + + +E W
Sbjct: 270 STQPNGGLSHTG--TPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENW 327
Query: 398 WFGSLNGKKGHFPAAYVEEL 417
+ G L+G G FP YVE L
Sbjct: 328 YEGMLHGHSGFFPINYVEIL 347
>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
Length = 628
Score = 64.3 bits (155), Expect = 2e-10
Identities = 33/99 (33%), Positives = 54/99 (54%), Gaps = 4/99 (4%)
Query: 322 VKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNL 381
+++ FL +E + K + P SS + S CK ++ ++A+ DDEL +
Sbjct: 194 IEVENDFLP--VEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 251
Query: 382 EKGDIVIIHEKK--EEGWWFGSLNGKKGHFPAAYVEELP 418
++GDIV + K + GWW G LNG++G FP +V+ LP
Sbjct: 252 KEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLP 290
Score = 61.6 bits (148), Expect = 1e-09
Identities = 26/55 (47%), Positives = 38/55 (69%)
Query: 363 RLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 417
R C+ +S+ + DDEL L+ GDI+ + + EEGWW G LNGK G FP+ +++EL
Sbjct: 64 RRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 118
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 64.3 bits (155), Expect = 2e-10
Identities = 33/99 (33%), Positives = 54/99 (54%), Gaps = 4/99 (4%)
Query: 322 VKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNL 381
+++ FL +E + K + P SS + S CK ++ ++A+ DDEL +
Sbjct: 231 IEVENDFLP--VEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 288
Query: 382 EKGDIVIIHEKK--EEGWWFGSLNGKKGHFPAAYVEELP 418
++GDIV + K + GWW G LNG++G FP +V+ LP
Sbjct: 289 KEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLP 327
Score = 61.6 bits (148), Expect = 1e-09
Identities = 26/55 (47%), Positives = 38/55 (69%)
Query: 363 RLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 417
R C+ +S+ + DDEL L+ GDI+ + + EEGWW G LNGK G FP+ +++EL
Sbjct: 101 RRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 155
Score = 53.1 bits (126), Expect = 5e-07
Identities = 20/49 (40%), Positives = 33/49 (67%)
Query: 369 YSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 417
+ +QA+ DDEL + G+I+ K++ GWW G +NG++G FP +V E+
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREI 56
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 61.6 bits (148), Expect = 1e-09
Identities = 27/65 (41%), Positives = 43/65 (66%)
Query: 364 LCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSNAGN 423
+ KA ++F+ +DEL++ KGDI+ + +E GWW G+LNG+ G FP+ YV E+ S+
Sbjct: 164 IVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERP 223
Query: 424 TATKA 428
+ KA
Sbjct: 224 LSPKA 228
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 59.7 bits (143), Expect = 5e-09
Identities = 31/67 (46%), Positives = 44/67 (65%), Gaps = 2/67 (2%)
Query: 351 STPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIV-IIHEKKEEGWWFGSLNGKKGHF 409
S PA G+ + KA Y F AR EL+L++GDI+ I+++K ++GWW G + G+ G F
Sbjct: 774 SRPAVGSTKYFGT-AKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWF 832
Query: 410 PAAYVEE 416
PA YVEE
Sbjct: 833 PANYVEE 839
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 59.3 bits (142), Expect = 6e-09
Identities = 24/63 (38%), Positives = 41/63 (65%)
Query: 366 KALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSNAGNTA 425
+A ++FQ +DEL+ KGD++ + +E GWW G+LNG+ G FP+ YV E+ ++ +
Sbjct: 12 RAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVS 71
Query: 426 TKA 428
K+
Sbjct: 72 PKS 74
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 59.3 bits (142), Expect = 6e-09
Identities = 24/63 (38%), Positives = 41/63 (65%)
Query: 366 KALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSNAGNTA 425
+A ++FQ +DEL+ KGD++ + +E GWW G+LNG+ G FP+ YV E+ ++ +
Sbjct: 140 RAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVS 199
Query: 426 TKA 428
K+
Sbjct: 200 PKS 202
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 59.3 bits (142), Expect = 6e-09
Identities = 24/63 (38%), Positives = 41/63 (65%)
Query: 366 KALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSNAGNTA 425
+A ++FQ +DEL+ KGD++ + +E GWW G+LNG+ G FP+ YV E+ ++ +
Sbjct: 190 RAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVS 249
Query: 426 TKA 428
K+
Sbjct: 250 PKS 252
>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
sapiens]
Length = 782
Score = 59.3 bits (142), Expect = 6e-09
Identities = 24/63 (38%), Positives = 41/63 (65%)
Query: 366 KALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSNAGNTA 425
+A ++FQ +DEL+ KGD++ + +E GWW G+LNG+ G FP+ YV E+ ++ +
Sbjct: 169 RAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVS 228
Query: 426 TKA 428
K+
Sbjct: 229 PKS 231
>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 59.3 bits (142), Expect = 6e-09
Identities = 24/63 (38%), Positives = 41/63 (65%)
Query: 366 KALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSNAGNTA 425
+A ++FQ +DEL+ KGD++ + +E GWW G+LNG+ G FP+ YV E+ ++ +
Sbjct: 12 RAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVS 71
Query: 426 TKA 428
K+
Sbjct: 72 PKS 74
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 59.3 bits (142), Expect = 6e-09
Identities = 38/103 (36%), Positives = 51/103 (49%), Gaps = 4/103 (3%)
Query: 319 HSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKAL-YSFQARQDD 377
H PFL +R S SN G S P + R L + FQA+
Sbjct: 341 HKMADGGSPFLGRRDFVYPSSTRDPSASNGGGS---PARREEKKRKAARLKFDFQAQSPK 397
Query: 378 ELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSN 420
EL L+KGDIV IH++ ++ W G +G+ G FPA YVE LP++
Sbjct: 398 ELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPAD 440
Score = 44.3 bits (103), Expect = 2e-04
Identities = 25/76 (32%), Positives = 42/76 (55%), Gaps = 3/76 (3%)
Query: 342 SGGQSNP-GSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFG 400
S G S+P T +P +Q+ +A+Y ++ + +DEL L +GD V + ++ ++GW+ G
Sbjct: 593 SRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVG 652
Query: 401 --SLNGKKGHFPAAYV 414
K G FP YV
Sbjct: 653 VSRRTQKFGTFPGNYV 668
Score = 38.5 bits (88), Expect = 0.012
Identities = 18/51 (35%), Positives = 31/51 (60%), Gaps = 2/51 (3%)
Query: 367 ALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSL--NGKKGHFPAAYVE 415
A Y+F+ + EL+ KG+ + + K E W+ G + G++G FPA+YV+
Sbjct: 461 AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 511
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 58.9 bits (141), Expect = 8e-09
Identities = 37/95 (38%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 327 PFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKAL-YSFQARQDDELNLEKGD 385
PFL +R S SN G S P + R L + FQA+ EL L+KGD
Sbjct: 7 PFLGRRDFVYPSSTRDPSASNGGGS---PARREEKKRKAARLKFDFQAQSPKELTLQKGD 63
Query: 386 IVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSN 420
IV IH++ ++ W G +G+ G FPA YVE LP++
Sbjct: 64 IVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPAD 98
Score = 44.3 bits (103), Expect = 2e-04
Identities = 25/76 (32%), Positives = 42/76 (55%), Gaps = 3/76 (3%)
Query: 342 SGGQSNP-GSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFG 400
S G S+P T +P +Q+ +A+Y ++ + +DEL L +GD V + ++ ++GW+ G
Sbjct: 251 SRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVG 310
Query: 401 --SLNGKKGHFPAAYV 414
K G FP YV
Sbjct: 311 VSRRTQKFGTFPGNYV 326
Score = 38.5 bits (88), Expect = 0.012
Identities = 18/51 (35%), Positives = 31/51 (60%), Gaps = 2/51 (3%)
Query: 367 ALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSL--NGKKGHFPAAYVE 415
A Y+F+ + EL+ KG+ + + K E W+ G + G++G FPA+YV+
Sbjct: 119 AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 169
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 58.5 bits (140), Expect = 1e-08
Identities = 31/84 (36%), Positives = 47/84 (55%), Gaps = 5/84 (5%)
Query: 336 IVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKK-- 393
+ S + G S SST + G+A + L ALY ++AR +DEL+L +G +V + +
Sbjct: 14 VSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAA 73
Query: 394 ---EEGWWFGSLNGKKGHFPAAYV 414
+EGWW G + + G FPA YV
Sbjct: 74 VSGDEGWWAGQVQRRLGIFPANYV 97
>gi|55956916 myosin IE [Homo sapiens]
Length = 1108
Score = 58.5 bits (140), Expect = 1e-08
Identities = 30/76 (39%), Positives = 42/76 (55%), Gaps = 6/76 (7%)
Query: 342 SGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGS 401
+GG+ P P P Q CKALY++ A+ DEL+ DI+ I ++ GWW G
Sbjct: 1039 AGGRPKP-QPKPKPQVPQ-----CKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGR 1092
Query: 402 LNGKKGHFPAAYVEEL 417
L GK+G FP YV ++
Sbjct: 1093 LRGKQGLFPNNYVTKI 1108
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 58.2 bits (139), Expect = 1e-08
Identities = 28/64 (43%), Positives = 40/64 (62%), Gaps = 3/64 (4%)
Query: 363 RLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEEL---PS 419
R CK +S+ Q DEL L+ G+IV + ++ E+GWW G NG+ G FP+ +VE L P
Sbjct: 86 RWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145
Query: 420 NAGN 423
+ GN
Sbjct: 146 SLGN 149
Score = 44.7 bits (104), Expect = 2e-04
Identities = 19/51 (37%), Positives = 31/51 (60%), Gaps = 2/51 (3%)
Query: 366 KALYSFQARQDDELNLEKGDIVIIHEK--KEEGWWFGSLNGKKGHFPAAYV 414
+ L+ +Q DEL L +GD+V + K +++GWW G G++G FP +V
Sbjct: 187 RVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 237
Score = 38.9 bits (89), Expect = 0.009
Identities = 19/52 (36%), Positives = 30/52 (57%), Gaps = 1/52 (1%)
Query: 368 LYSFQARQDDELNLEKGDIVI-IHEKKEEGWWFGSLNGKKGHFPAAYVEELP 418
L ++A+++DEL+L GD+V + GW G G+ G FP V+E+P
Sbjct: 6 LAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIP 57
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 58.2 bits (139), Expect = 1e-08
Identities = 47/197 (23%), Positives = 81/197 (41%), Gaps = 8/197 (4%)
Query: 227 KLLRLQRDIEKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSY 286
K + Q+ K ++ ++ T S +S D ++NL L +A S
Sbjct: 295 KTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQ 354
Query: 287 KLSSMLAELEQRPQPSHPCSNSIFRWRE----KEHTHSYVKISRPFLMKRLE----NIVS 338
+ L RP+P HP + R K+ ++Y++ + R+ I++
Sbjct: 355 VFKNQDPVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIIT 414
Query: 339 KASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWW 398
+S P + A + L+ F A Q D+LNL G+IV + EK + W+
Sbjct: 415 PLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWY 474
Query: 399 FGSLNGKKGHFPAAYVE 415
G+ + G FPA YV+
Sbjct: 475 RGNCRNQIGIFPANYVK 491
Score = 51.2 bits (121), Expect = 2e-06
Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 8/84 (9%)
Query: 338 SKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGW 397
+K G ++ +S PA C+AL+SF A D+L+ ++GD + I E+ + W
Sbjct: 588 TKKEDSGSNSQVNSLPA--------EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDW 639
Query: 398 WFGSLNGKKGHFPAAYVEELPSNA 421
G L ++G FPA +V P+ A
Sbjct: 640 CRGRLQDREGIFPAVFVRPCPAEA 663
Score = 50.4 bits (119), Expect = 3e-06
Identities = 23/55 (41%), Positives = 32/55 (58%)
Query: 363 RLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 417
R KALY F+ +DEL+ + GDI+ E ++ W G L GK G FP Y++ L
Sbjct: 674 RKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
Score = 44.3 bits (103), Expect = 2e-04
Identities = 21/62 (33%), Positives = 34/62 (54%), Gaps = 3/62 (4%)
Query: 365 CKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAY---VEELPSNA 421
C A + + Q DEL+ +G+I+I+ E E W G + G+ G FP + VE+ P++
Sbjct: 517 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSG 576
Query: 422 GN 423
N
Sbjct: 577 AN 578
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 58.2 bits (139), Expect = 1e-08
Identities = 47/197 (23%), Positives = 81/197 (41%), Gaps = 8/197 (4%)
Query: 227 KLLRLQRDIEKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSY 286
K + Q+ K ++ ++ T S +S D ++NL L +A S
Sbjct: 331 KTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQ 390
Query: 287 KLSSMLAELEQRPQPSHPCSNSIFRWRE----KEHTHSYVKISRPFLMKRLE----NIVS 338
+ L RP+P HP + R K+ ++Y++ + R+ I++
Sbjct: 391 VFKNQDPVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIIT 450
Query: 339 KASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWW 398
+S P + A + L+ F A Q D+LNL G+IV + EK + W+
Sbjct: 451 PLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWY 510
Query: 399 FGSLNGKKGHFPAAYVE 415
G+ + G FPA YV+
Sbjct: 511 RGNCRNQIGIFPANYVK 527
Score = 51.2 bits (121), Expect = 2e-06
Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 8/84 (9%)
Query: 338 SKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGW 397
+K G ++ +S PA C+AL+SF A D+L+ ++GD + I E+ + W
Sbjct: 624 TKKEDSGSNSQVNSLPA--------EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDW 675
Query: 398 WFGSLNGKKGHFPAAYVEELPSNA 421
G L ++G FPA +V P+ A
Sbjct: 676 CRGRLQDREGIFPAVFVRPCPAEA 699
Score = 50.4 bits (119), Expect = 3e-06
Identities = 23/55 (41%), Positives = 32/55 (58%)
Query: 363 RLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 417
R KALY F+ +DEL+ + GDI+ E ++ W G L GK G FP Y++ L
Sbjct: 710 RKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
Score = 44.3 bits (103), Expect = 2e-04
Identities = 21/62 (33%), Positives = 34/62 (54%), Gaps = 3/62 (4%)
Query: 365 CKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAY---VEELPSNA 421
C A + + Q DEL+ +G+I+I+ E E W G + G+ G FP + VE+ P++
Sbjct: 553 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSG 612
Query: 422 GN 423
N
Sbjct: 613 AN 614
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 57.0 bits (136), Expect = 3e-08
Identities = 27/55 (49%), Positives = 33/55 (60%)
Query: 363 RLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 417
R KAL F+ DDEL K DI+ I +K+E W G LNG +G FPA +VE L
Sbjct: 483 RRAKALLDFERHDDDELGFRKNDIITIVSQKDEHCWVGELNGLRGWFPAKFVEVL 537
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 56.6 bits (135), Expect = 4e-08
Identities = 101/458 (22%), Positives = 183/458 (39%), Gaps = 94/458 (20%)
Query: 35 KSLDNEVEKTANLVISNWNQQIKAKKKLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNK 94
KS NE KTA ++ K L +KH+A F+ S+ QS ++
Sbjct: 586 KSWVNEKMKTAT------DEAYKDPSNLQGKVQKHQA-FEAELSANQSR--------IDA 630
Query: 95 LTKSTEKLEKEDENYYQKNMAGYSTRLK-----WENTLENCYQSILELEKERIQLLCNN- 148
L K+ +KL D N+Y K+ + R+ W+ LE ++L + Q N
Sbjct: 631 LEKAGQKLI--DVNHYAKDEV--AARMNEVISLWKKLLEATELKGIKLREANQQQQFNRN 686
Query: 149 -------LNQYSQHISL--FGQTLTTCHT-QIHCAISKIDIEKD--------IQA-VMEE 189
L + H++ +G+ LT Q A+ + D+ IQA ++
Sbjct: 687 VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQD 746
Query: 190 TAILSTEN---KSEFLLTDYFE-EDPNSAMDKERRKSLLKPKLLRLQRDIEKASKDKE-- 243
EN K E L+ Y ++P A ++ SL +L R D E ++KE
Sbjct: 747 AGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPI 806
Query: 244 -----------GLERMLKTYSSTSSFSDAKSQKDTA------ALMDENNLKLDLLEANSY 286
G++ +LK + + + + A A+++E + + ++A +
Sbjct: 807 AASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLH 866
Query: 287 KLS----SMLAELEQRPQPSHPCSNSIFRWREKEHTHSYVKISRPF-------------- 328
+L+ ++ A+ QR Q + + + S+++ P
Sbjct: 867 ELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAE 926
Query: 329 -LMKRLENIVSKASSGG--------QSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDEL 379
L+K+ E ++S S+ G Q+ AP + L ALY +Q + E+
Sbjct: 927 ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREV 986
Query: 380 NLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 417
++KGDI+ + + WW +N ++G PAAYV++L
Sbjct: 987 TMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKL 1024
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 56.6 bits (135), Expect = 4e-08
Identities = 101/458 (22%), Positives = 183/458 (39%), Gaps = 94/458 (20%)
Query: 35 KSLDNEVEKTANLVISNWNQQIKAKKKLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNK 94
KS NE KTA ++ K L +KH+A F+ S+ QS ++
Sbjct: 586 KSWVNEKMKTAT------DEAYKDPSNLQGKVQKHQA-FEAELSANQSR--------IDA 630
Query: 95 LTKSTEKLEKEDENYYQKNMAGYSTRLK-----WENTLENCYQSILELEKERIQLLCNN- 148
L K+ +KL D N+Y K+ + R+ W+ LE ++L + Q N
Sbjct: 631 LEKAGQKLI--DVNHYAKDEV--AARMNEVISLWKKLLEATELKGIKLREANQQQQFNRN 686
Query: 149 -------LNQYSQHISL--FGQTLTTCHT-QIHCAISKIDIEKD--------IQA-VMEE 189
L + H++ +G+ LT Q A+ + D+ IQA ++
Sbjct: 687 VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQD 746
Query: 190 TAILSTEN---KSEFLLTDYFE-EDPNSAMDKERRKSLLKPKLLRLQRDIEKASKDKE-- 243
EN K E L+ Y ++P A ++ SL +L R D E ++KE
Sbjct: 747 AGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPI 806
Query: 244 -----------GLERMLKTYSSTSSFSDAKSQKDTA------ALMDENNLKLDLLEANSY 286
G++ +LK + + + + A A+++E + + ++A +
Sbjct: 807 AASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLH 866
Query: 287 KLS----SMLAELEQRPQPSHPCSNSIFRWREKEHTHSYVKISRPF-------------- 328
+L+ ++ A+ QR Q + + + S+++ P
Sbjct: 867 ELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAE 926
Query: 329 -LMKRLENIVSKASSGG--------QSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDEL 379
L+K+ E ++S S+ G Q+ AP + L ALY +Q + E+
Sbjct: 927 ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREV 986
Query: 380 NLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 417
++KGDI+ + + WW +N ++G PAAYV++L
Sbjct: 987 TMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKL 1024
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 55.8 bits (133), Expect = 7e-08
Identities = 57/220 (25%), Positives = 95/220 (43%), Gaps = 34/220 (15%)
Query: 204 TDYFEEDPNSAMDKERRKSLLKPKLLRLQR--DIEKASKDKEGLERMLKTYSSTSSFSDA 261
T F +P S + E KS +L+ +R + ++S D+ LER + + S S F
Sbjct: 121 TRKFRSEPRSIFEYEPGKS----SILQHERPASLYQSSIDRS-LERPMSSASMASDFRKR 175
Query: 262 KSQKDTAA----LMDENNLKLDLLEANSYKLSSMLAELEQRPQPSHPCSNSIFRWREKEH 317
+ + L D++ + + S+ L + PS P R +++E
Sbjct: 176 RKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-----RAKDRES 230
Query: 318 THSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDD 377
SY S + G+S P P +L + KA+Y F+A+
Sbjct: 231 PRSYS---------------STLTDMGRSAPRERRGTPEKEKLPA---KAVYDFKAQTSK 272
Query: 378 ELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 417
EL+ +KGD V I K ++ W+ G +G+ G FP +YVE+L
Sbjct: 273 ELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 312
Score = 47.8 bits (112), Expect = 2e-05
Identities = 34/111 (30%), Positives = 55/111 (49%), Gaps = 12/111 (10%)
Query: 312 WREKEHTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSF 371
W E EH H V I P + V K + ++ P P ++ + K Y+F
Sbjct: 292 WYEGEH-HGRVGIF-PI------SYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK--YNF 341
Query: 372 QARQDDELNLEKGDIVIIHEKKEEGWWFGSLNG--KKGHFPAAYVEELPSN 420
A + EL+L KGD VI+ ++ ++ W+ G + G ++G FP +YVE + N
Sbjct: 342 NADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 392
Score = 46.2 bits (108), Expect = 6e-05
Identities = 21/54 (38%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Query: 366 KALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKK--GHFPAAYVEEL 417
+ALY++ R +DEL L + D++ + EK ++GW+ G+ K G FP YV+ L
Sbjct: 439 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.344
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,245,112
Number of Sequences: 37866
Number of extensions: 657966
Number of successful extensions: 4342
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 222
Number of HSP's successfully gapped in prelim test: 425
Number of HSP's that attempted gapping in prelim test: 3468
Number of HSP's gapped (non-prelim): 1173
length of query: 428
length of database: 18,247,518
effective HSP length: 105
effective length of query: 323
effective length of database: 14,271,588
effective search space: 4609722924
effective search space used: 4609722924
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.