Search of human proteins with 157674358

Search of human proteins with 157674358

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157674358 leucine rich repeat containing 50 [Homo sapiens]
         (725 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157674358 leucine rich repeat containing 50 [Homo sapiens]        1471   0.0  
gi|55743114 leucine rich repeat containing 49 [Homo sapiens]           92   1e-18
gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo sap...    88   2e-17
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  83   8e-16
gi|194272228 leucine rich repeat containing 48 isoform b [Homo s...    80   5e-15
gi|194272226 leucine rich repeat containing 48 isoform b [Homo s...    80   5e-15
gi|194272224 leucine rich repeat containing 48 isoform a [Homo s...    80   5e-15
gi|194272222 leucine rich repeat containing 48 isoform a [Homo s...    80   5e-15
gi|61966709 leucine rich repeat containing 67 [Homo sapiens]           76   1e-13
gi|15529980 leucine rich repeat containing 46 [Homo sapiens]           75   3e-13
gi|21389483 leucine-rich repeats and guanylate kinase domain con...    71   4e-12
gi|31621309 leucine rich repeat containing 6 [Homo sapiens]            70   9e-12
gi|239752518 PREDICTED: similar to leucine rich repeat containin...    67   4e-11
gi|117414162 sodium channel associated protein 2 isoform a [Homo...    67   4e-11
gi|33286446 opioid growth factor receptor [Homo sapiens]               60   7e-09
gi|53828918 Rab geranylgeranyltransferase alpha [Homo sapiens]         60   7e-09
gi|33469951 Rab geranylgeranyltransferase alpha [Homo sapiens]         60   7e-09
gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 famil...    59   2e-08
gi|4503743 flightless I homolog [Homo sapiens]                         57   5e-08
gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 famil...    57   6e-08
gi|31377705 centrosomal protein 97kDa [Homo sapiens]                   57   6e-08
gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 fami...    55   2e-07
gi|56549694 enabled homolog isoform a [Homo sapiens]                   55   3e-07
gi|39930375 enabled homolog isoform b [Homo sapiens]                   55   3e-07
gi|157738619 smoothelin-like 1 [Homo sapiens]                          54   4e-07
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              54   7e-07
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    54   7e-07
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     53   9e-07
gi|164607156 axonemal dynein light chain 1 [Homo sapiens]              52   1e-06
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]           52   2e-06

>gi|157674358 leucine rich repeat containing 50 [Homo sapiens]
          Length = 725

 Score = 1471 bits (3807), Expect = 0.0
 Identities = 725/725 (100%), Positives = 725/725 (100%)

Query: 1   MHPEPSEPATGGAAELDCAQEPGVEESAGDHGSAGRGGCKEEINDPKEICVGSSDTSYHS 60
           MHPEPSEPATGGAAELDCAQEPGVEESAGDHGSAGRGGCKEEINDPKEICVGSSDTSYHS
Sbjct: 1   MHPEPSEPATGGAAELDCAQEPGVEESAGDHGSAGRGGCKEEINDPKEICVGSSDTSYHS 60

Query: 61  QQKQSGDNGSGGHFAHPREDREDRGPRMTKSSLQKLCKQHKLYITPALNDTLYLHFKGFD 120
           QQKQSGDNGSGGHFAHPREDREDRGPRMTKSSLQKLCKQHKLYITPALNDTLYLHFKGFD
Sbjct: 61  QQKQSGDNGSGGHFAHPREDREDRGPRMTKSSLQKLCKQHKLYITPALNDTLYLHFKGFD 120

Query: 121 RIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNL 180
           RIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNL
Sbjct: 121 RIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNL 180

Query: 181 SNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSI 240
           SNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSI
Sbjct: 181 SNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSI 240

Query: 241 LESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYA 300
           LESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYA
Sbjct: 241 LESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYA 300

Query: 301 AEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAE 360
           AEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAE
Sbjct: 301 AEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAE 360

Query: 361 GKEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEAKREDGGPEPEGTLPAET 420
           GKEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEAKREDGGPEPEGTLPAET
Sbjct: 361 GKEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEAKREDGGPEPEGTLPAET 420

Query: 421 LLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPPVEVKGEDGDQEPEGTLPAETLLLSPPVK 480
           LLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPPVEVKGEDGDQEPEGTLPAETLLLSPPVK
Sbjct: 421 LLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPPVEVKGEDGDQEPEGTLPAETLLLSPPVK 480

Query: 481 VKGEDGDREPEGTLPAEAPPPPPLGAAREEPTPQAVATEGVFVTELDGTRTEDLETIRLE 540
           VKGEDGDREPEGTLPAEAPPPPPLGAAREEPTPQAVATEGVFVTELDGTRTEDLETIRLE
Sbjct: 481 VKGEDGDREPEGTLPAEAPPPPPLGAAREEPTPQAVATEGVFVTELDGTRTEDLETIRLE 540

Query: 541 TKETFCIDDLPDLEDDDETGKSLEDQNMCFPKIEVISSLSDDSDPELDYTSLPVLENLPT 600
           TKETFCIDDLPDLEDDDETGKSLEDQNMCFPKIEVISSLSDDSDPELDYTSLPVLENLPT
Sbjct: 541 TKETFCIDDLPDLEDDDETGKSLEDQNMCFPKIEVISSLSDDSDPELDYTSLPVLENLPT 600

Query: 601 DTLSNIFAVSKDTSKAARVPFTDIFKKEAKRDLEIRKQDTKSPRPLIQELSDEDPSGQLL 660
           DTLSNIFAVSKDTSKAARVPFTDIFKKEAKRDLEIRKQDTKSPRPLIQELSDEDPSGQLL
Sbjct: 601 DTLSNIFAVSKDTSKAARVPFTDIFKKEAKRDLEIRKQDTKSPRPLIQELSDEDPSGQLL 660

Query: 661 MPPTCQRDAAPLTSSGDRDSDFLAASSPVPTESAATPPETCVGVAQPSQALPTWDLTAFP 720
           MPPTCQRDAAPLTSSGDRDSDFLAASSPVPTESAATPPETCVGVAQPSQALPTWDLTAFP
Sbjct: 661 MPPTCQRDAAPLTSSGDRDSDFLAASSPVPTESAATPPETCVGVAQPSQALPTWDLTAFP 720

Query: 721 APKAS 725
           APKAS
Sbjct: 721 APKAS 725


>gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
          Length = 686

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 68/208 (32%), Positives = 104/208 (50%), Gaps = 4/208 (1%)

Query: 111 TLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLE 170
           +L L+    + I  L     LR L L  N I+KI NLE    L  L L  N + KIEN+ 
Sbjct: 138 SLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENIN 197

Query: 171 PLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHN 230
            L +L  LNL+ N++  ++NL+ L  L  L + HN +  V D+ +L  CL+   L LS N
Sbjct: 198 HLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNL-PCLQ--HLFLSFN 254

Query: 231 KLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRAC 290
            +S  + +S L     L  +   GNP I Q   Y+ TV   +  L  LD + +  ++R  
Sbjct: 255 NISSFDSVSCLADSSSLSDITFDGNP-IAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 313

Query: 291 AEAWARGGYAAEKEERQQWESRERKKIT 318
           A   A+     ++E  +Q   +E+K++T
Sbjct: 314 ASVLAKKEEEKKRESHKQSLLKEKKRLT 341


>gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo
           sapiens]
          Length = 360

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 63/156 (40%), Positives = 88/156 (56%), Gaps = 7/156 (4%)

Query: 122 IENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLS 181
           IENLEE   LR L L  N I+KIENLEA TEL  L +  NLLR IE ++ L +L  L L 
Sbjct: 113 IENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLV 172

Query: 182 NNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSIL 241
           NN I  IENLS L  L  L++  N +  +E+I  L     L  L L  NK++    L  L
Sbjct: 173 NNKISKIENLSNLHQLQMLELGSNRIRAIENIDTL---TNLESLFLGKNKITK---LQNL 226

Query: 242 ESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTY 277
           +++ +L VL++  N  + +I   +  V +R  +L++
Sbjct: 227 DALTNLTVLSMQSNR-LTKIEGLQNLVNLRELYLSH 261



 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 64/189 (33%), Positives = 92/189 (48%), Gaps = 11/189 (5%)

Query: 91  SSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQ 150
           S ++ L   H+L +       L L       IEN++  T L  L+L  N I K++NL+A 
Sbjct: 177 SKIENLSNLHQLQM-------LELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDAL 229

Query: 151 TELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETV 210
           T L  L +Q N L KIE L+ L  L  L LS+N I+ IE L     L  L +A N ++ +
Sbjct: 230 TNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKI 289

Query: 211 EDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTV 270
           E+I HL E     + D   N L     L  L+    L  + L  NP +++ P YRR V +
Sbjct: 290 ENISHLTELQEFWMND---NLLESWSDLDELKGARSLETVYLERNP-LQKDPQYRRKVML 345

Query: 271 RLKHLTYLD 279
            L  +  +D
Sbjct: 346 ALPSVRQID 354



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 59/171 (34%), Positives = 91/171 (53%), Gaps = 15/171 (8%)

Query: 110 DTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENL 169
           + L + F     IE +++ T L+ L+L +N I KIENL    +L+ L L  N +R IEN+
Sbjct: 145 EILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENI 204

Query: 170 EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSH 229
           + L  L++L L  N I  ++NL  L  L  L M  N L  +E +Q+L   + L  L LSH
Sbjct: 205 DTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNL---VNLRELYLSH 261

Query: 230 NKLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDD 280
           N +   E++  LE+   L +L++  N  I++I N        + HLT L +
Sbjct: 262 NGI---EVIEGLENNNKLTMLDIASNR-IKKIEN--------ISHLTELQE 300



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 57/192 (29%), Positives = 96/192 (50%), Gaps = 12/192 (6%)

Query: 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEP 171
           L L+     +IENLE  T L  L +  N ++ IE ++  T L+ LFL  N + KIENL  
Sbjct: 125 LDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSN 184

Query: 172 LQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNK 231
           L +L  L L +N I+ IEN+  L  L +L +  N    +  +Q+L     L VL +  N+
Sbjct: 185 LHQLQMLELGSNRIRAIENIDTLTNLESLFLGKN---KITKLQNLDALTNLTVLSMQSNR 241

Query: 232 LSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTV--------RLKHLTYLDDRPV 283
           L+  E L  L ++ +L  L+  G  VI  + N  +   +        +++++++L +   
Sbjct: 242 LTKIEGLQNLVNLREL-YLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE 300

Query: 284 FPKDRACAEAWA 295
           F  +    E+W+
Sbjct: 301 FWMNDNLLESWS 312



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 60/221 (27%), Positives = 105/221 (47%), Gaps = 15/221 (6%)

Query: 33  SAGRGGCKEEINDPKEICVGSSDTSYHSQQK--QSGDNGSGGHFAHPRE----DREDRGP 86
           +A RG  +++  +  E+     D    S++   + G   S G  A   E    D E+RG 
Sbjct: 2   AAERGAGQQQSQEMMEV-----DRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGE 56

Query: 87  RMTKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIEN 146
              +   +       + +     D    H++   +IE  E    ++ L L+ N I+ IEN
Sbjct: 57  EDPEEEHELPVDMETINLDRDAEDVDLNHYR-IGKIEGFEVLKKVKTLCLRQNLIKCIEN 115

Query: 147 LEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNH 206
           LE    LR L L  N ++KIENLE L +L+ L++S N ++ IE +  L  L  L + +N 
Sbjct: 116 LEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNK 175

Query: 207 LETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDL 247
           +  +E++ +L +   L +L+L  N++   E +  L ++  L
Sbjct: 176 ISKIENLSNLHQ---LQMLELGSNRIRAIENIDTLTNLESL 213


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 83.2 bits (204), Expect = 8e-16
 Identities = 86/268 (32%), Positives = 128/268 (47%), Gaps = 22/268 (8%)

Query: 103 YITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQK---IENLEAQTELRCLFLQ 159
           YIT AL        K   + +NL     L  L L  +G +K   IENLE   +L  L L 
Sbjct: 82  YITEAL-------IKKLTKQDNLALIKSLN-LSLSKDGGKKFKYIENLEKCVKLEVLNLS 133

Query: 160 MNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQEC 219
            NL+ KIE L+ L KL  LNLS N I  IE +  +  L  L +A N +E +  +   ++ 
Sbjct: 134 YNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHI-PVWLGKKL 192

Query: 220 LRLCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLD 279
             L VL+L  NK+S  + +S L+ + DL  L L+ NPV+  +P+Y +     L+ L  L+
Sbjct: 193 KSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVV-TLPHYLQFTIFHLRSLESLE 251

Query: 280 DRPVFPKDRACAEAWARGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQ-- 337
            +PV  +DR   EA+ R       EE ++ E    KK+ ++ E  +   +  EE K Q  
Sbjct: 252 GQPVTTQDR--QEAFER----FSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDK 305

Query: 338 -RESQERGEMTSSDDGENVPASAEGKEE 364
             +S +   M      E + +    K E
Sbjct: 306 LNKSLKEEAMLQKQSCEELKSDLNTKNE 333


>gi|194272228 leucine rich repeat containing 48 isoform b [Homo
           sapiens]
          Length = 457

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 59/171 (34%), Positives = 89/171 (52%), Gaps = 7/171 (4%)

Query: 83  DRGPRMTKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQ 142
           D+GP+       +L KQ  +     L+  L L F+   RI+NL ++  LR L L +N I+
Sbjct: 24  DQGPQ---EEAGQLAKQEGILFKDVLS--LQLDFRNILRIDNLWQFENLRKLQLDNNIIE 78

Query: 143 KIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQM 202
           KIE LE    L  L L  N +  IE L+ L  L+ L+L NN I  I++L  L  L  L +
Sbjct: 79  KIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSL 138

Query: 203 AHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPE--ILSILESMPDLRVLN 251
            +N ++ + +I +L+    L  L LS N +S+ E   + I   +PDL  L+
Sbjct: 139 GNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLD 189


>gi|194272226 leucine rich repeat containing 48 isoform b [Homo
           sapiens]
          Length = 457

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 59/171 (34%), Positives = 89/171 (52%), Gaps = 7/171 (4%)

Query: 83  DRGPRMTKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQ 142
           D+GP+       +L KQ  +     L+  L L F+   RI+NL ++  LR L L +N I+
Sbjct: 24  DQGPQ---EEAGQLAKQEGILFKDVLS--LQLDFRNILRIDNLWQFENLRKLQLDNNIIE 78

Query: 143 KIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQM 202
           KIE LE    L  L L  N +  IE L+ L  L+ L+L NN I  I++L  L  L  L +
Sbjct: 79  KIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSL 138

Query: 203 AHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPE--ILSILESMPDLRVLN 251
            +N ++ + +I +L+    L  L LS N +S+ E   + I   +PDL  L+
Sbjct: 139 GNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLD 189


>gi|194272224 leucine rich repeat containing 48 isoform a [Homo
           sapiens]
          Length = 523

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 59/171 (34%), Positives = 89/171 (52%), Gaps = 7/171 (4%)

Query: 83  DRGPRMTKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQ 142
           D+GP+       +L KQ  +     L+  L L F+   RI+NL ++  LR L L +N I+
Sbjct: 24  DQGPQ---EEAGQLAKQEGILFKDVLS--LQLDFRNILRIDNLWQFENLRKLQLDNNIIE 78

Query: 143 KIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQM 202
           KIE LE    L  L L  N +  IE L+ L  L+ L+L NN I  I++L  L  L  L +
Sbjct: 79  KIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSL 138

Query: 203 AHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPE--ILSILESMPDLRVLN 251
            +N ++ + +I +L+    L  L LS N +S+ E   + I   +PDL  L+
Sbjct: 139 GNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLD 189


>gi|194272222 leucine rich repeat containing 48 isoform a [Homo
           sapiens]
          Length = 523

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 59/171 (34%), Positives = 89/171 (52%), Gaps = 7/171 (4%)

Query: 83  DRGPRMTKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQ 142
           D+GP+       +L KQ  +     L+  L L F+   RI+NL ++  LR L L +N I+
Sbjct: 24  DQGPQ---EEAGQLAKQEGILFKDVLS--LQLDFRNILRIDNLWQFENLRKLQLDNNIIE 78

Query: 143 KIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQM 202
           KIE LE    L  L L  N +  IE L+ L  L+ L+L NN I  I++L  L  L  L +
Sbjct: 79  KIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSL 138

Query: 203 AHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPE--ILSILESMPDLRVLN 251
            +N ++ + +I +L+    L  L LS N +S+ E   + I   +PDL  L+
Sbjct: 139 GNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLD 189


>gi|61966709 leucine rich repeat containing 67 [Homo sapiens]
          Length = 228

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 66/206 (32%), Positives = 93/206 (45%), Gaps = 32/206 (15%)

Query: 104 ITPALNDTLYLHF--KGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMN 161
           I+  L    +++F  K  D IE+L     L  L+L  N I +I NL   T L  L+LQ N
Sbjct: 23  ISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNN 82

Query: 162 LLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLR 221
            +  IENL  L+KL+ L L  NYI  IE L  L  L  L + +  L   E +      L 
Sbjct: 83  CISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLH 142

Query: 222 -----LCVLDLSHNKLSDPEILSILESMPDLRV-----------------------LNLM 253
                LC+L++S+N + D   L +LE++  L                         ++L 
Sbjct: 143 SLAKSLCILNISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLN 202

Query: 254 GNPVIRQIPNYRRTVTVRLKHL-TYL 278
           GNPV  + P YR  + +  K L TYL
Sbjct: 203 GNPVCLK-PKYRDRLILVSKSLGTYL 227


>gi|15529980 leucine rich repeat containing 46 [Homo sapiens]
          Length = 321

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 63/196 (32%), Positives = 92/196 (46%), Gaps = 19/196 (9%)

Query: 152 ELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVE 211
           EL+ + L    +  I NLE LQ L +L L  N I+ IENL+C+P L  L +A N +  VE
Sbjct: 45  ELQTVRLDREGITTIRNLEGLQNLHSLYLQGNKIQQIENLACIPSLRFLSLAGNQIRQVE 104

Query: 212 DIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVR 271
           ++  L  CL+   LDLS N +   E L + E    L +LNL GN    Q   YR  VT  
Sbjct: 105 NLLDL-PCLQF--LDLSENLI---ETLKLDEFPQSLLILNLSGNSCTNQ-DGYRELVTEA 157

Query: 272 LKHLTYLDDRPVFPKDRACAEAWARGGYAAEKEERQQWESRERKKITDSIEALAMIKQRA 331
           L  L  LD +PV        E W      +++E+    +    +           +K+  
Sbjct: 158 LPLLLDLDGQPV-------VERW-----ISDEEDEASSDEEFPELSGPFCSERGFLKELE 205

Query: 332 EERKRQRESQERGEMT 347
           +E  R RE +++  +T
Sbjct: 206 QELSRHREHRQQTALT 221


>gi|21389483 leucine-rich repeats and guanylate kinase domain
           containing [Homo sapiens]
          Length = 825

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 53/168 (31%), Positives = 86/168 (51%), Gaps = 5/168 (2%)

Query: 124 NLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNN 183
           +L  Y  L  L L  N I++I  LE    L  L L  N +  I  L  L  +  L LSNN
Sbjct: 210 DLSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKLP-IKILCLSNN 268

Query: 184 YIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILES 243
            I+ I  L  L  L  L ++HN + +++ +++      L V++L  NK+++   +  +++
Sbjct: 269 QIEMITGLEDLKALQNLDLSHNQISSLQGLENHD---LLEVINLEDNKIAELREIEYIKN 325

Query: 244 MPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACA 291
           +P LRVLNL+ NP I++   Y   V   L  LT LD + +  +++  A
Sbjct: 326 LPILRVLNLLENP-IQEKSEYWFFVIFMLLRLTELDQKKIKVEEKVSA 372



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 26/76 (34%), Positives = 40/76 (52%), Gaps = 6/76 (7%)

Query: 172 LQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNK 231
           LQKLD   LS N I+ +  +SC+P L  L  + N+L T  + +  +    L   D SHN+
Sbjct: 151 LQKLD---LSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPK---NLKKADFSHNQ 204

Query: 232 LSDPEILSILESMPDL 247
           +S+   LS   ++  L
Sbjct: 205 ISEICDLSAYHALTKL 220


>gi|31621309 leucine rich repeat containing 6 [Homo sapiens]
          Length = 466

 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 59/220 (26%), Positives = 99/220 (45%), Gaps = 38/220 (17%)

Query: 134 LWLQSNGIQKIENLEAQT-ELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLS 192
           L L    I+++E+++    +L+ L+LQ NL+ KIEN+  L+KL+ LNL+ N I+ IENL 
Sbjct: 26  LSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENL- 84

Query: 193 CLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNL 252
                                   + C  L  LDL+ N + +   +  L+    L+ L L
Sbjct: 85  ------------------------EGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL 120

Query: 253 MGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAEKEERQQWESR 312
           MGNP      +YR  V   L  L +LD + + P +R  A            ++    E +
Sbjct: 121 MGNP-CASFDHYREFVVATLPQLKWLDGKEIEPSERIKA-----------LQDYSVIEPQ 168

Query: 313 ERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDG 352
            R++  D     A +K+ A+ + ++ +  E     +  DG
Sbjct: 169 IREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDG 208



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 37/115 (32%), Positives = 56/115 (48%), Gaps = 10/115 (8%)

Query: 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEP 171
           LYL      +IEN+ +   L  L L  N I+KIENLE   EL  L L +N + ++ +++ 
Sbjct: 49  LYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKN 108

Query: 172 LQ---KLDALNLSNNYIKTIEN-----LSCLPVLNTLQMAHNHLETVEDIQHLQE 218
           LQ    L  L L  N   + ++     ++ LP L  L      +E  E I+ LQ+
Sbjct: 109 LQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLD--GKEIEPSERIKALQD 161


>gi|239752518 PREDICTED: similar to leucine rich repeat containing
           50, partial [Homo sapiens]
          Length = 489

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 57/193 (29%), Positives = 85/193 (44%), Gaps = 32/193 (16%)

Query: 129 TGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNN---YI 185
           + L  L L  N I KIEN+    ELR L L  N L  ++NL  L  L  LNL +N   ++
Sbjct: 3   SNLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFV 62

Query: 186 KTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMP 245
           + ++NL CL                   QH         L LS N +S  + +S L    
Sbjct: 63  RDVDNLPCL-------------------QH---------LFLSFNNISSFDSVSCLADSS 94

Query: 246 DLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAEKEE 305
            L  +   GNP I Q   Y+ TV   +  L  LD + +  ++R  A   A+     ++E 
Sbjct: 95  SLSDITFDGNP-IAQESWYKHTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEKKRES 153

Query: 306 RQQWESRERKKIT 318
            +Q   +E+K++T
Sbjct: 154 HKQSLLKEKKRLT 166


>gi|117414162 sodium channel associated protein 2 isoform a [Homo
           sapiens]
          Length = 1032

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 58/176 (32%), Positives = 84/176 (47%), Gaps = 11/176 (6%)

Query: 117 KGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLD 176
           KG   I  L   + L  + L  N I KIE ++    L+ L L  N + +IE L  L KL 
Sbjct: 31  KGLQSISELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLNTLTKLC 90

Query: 177 ALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECL-RLCVLDLSHNKLSDP 235
            LNLS N I  +E L  L  L  L +++NH++ +  +  L     +L  +DL  N++   
Sbjct: 91  TLNLSCNLITKVEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRID-- 148

Query: 236 EILSILESMPDLRVL-NLM------GNPVIRQIPNYRRTVTVRLKHLTYLDDRPVF 284
            I  +L+ M  L  L NL+       NPV R +P YR  +   L  L  LD + +F
Sbjct: 149 SIHHLLQCMVGLHFLTNLILEKDGDDNPVCR-LPGYRAVILQTLPQLRILDCKNIF 203



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 55/168 (32%), Positives = 83/168 (49%), Gaps = 17/168 (10%)

Query: 107 ALNDTLY---LHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLL 163
           +L+ TL+   LH     +IE ++    L+ L L SN I +IE L   T+L  L L  NL+
Sbjct: 40  SLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLNTLTKLCTLNLSCNLI 99

Query: 164 RKIENLEPLQKLDALNLSNNYIKTIENLSCL-PVLNTLQMAHNHLETVEDIQHLQECL-- 220
            K+E LE L  L  LN+S N+I  +  L  L  + + L+    H   ++ I HL +C+  
Sbjct: 100 TKVEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVG 159

Query: 221 --RLCVLDLSHNKLSDPEI------LSILESMPDLRVL---NLMGNPV 257
              L  L L  +   +P          IL+++P LR+L   N+ G PV
Sbjct: 160 LHFLTNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPV 207



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 3/107 (2%)

Query: 143 KIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQM 202
           ++EN +  +    +      L+ I  L     L A+NL  N I  IE +  +  L  L +
Sbjct: 13  EVENEDGDSSCGDVCFMDKGLQSISELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDL 72

Query: 203 AHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRV 249
           + N +  +E +  L    +LC L+LS N ++  E L  L ++  L V
Sbjct: 73  SSNQISRIEGLNTL---TKLCTLNLSCNLITKVEGLEELINLTRLNV 116


>gi|33286446 opioid growth factor receptor [Homo sapiens]
          Length = 677

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 47/129 (36%), Positives = 56/129 (43%), Gaps = 12/129 (9%)

Query: 391 PEKPSGEEPPVEAKREDGGPEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPP 450
           P  P+G+EP  E+  E  GP P G  PA      SP E  G    G P    PAE+P   
Sbjct: 546 PAGPAGDEP-AESPSETPGPRPAG--PAGDEPAESPSETPGPSPAG-PTRDEPAESPSET 601

Query: 451 PPVEVKGEDGDQEPEGTLPAETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPPLGAAREE 510
           P     G  GD+  E   P+ET    P  +  G  GD   E   P+E P P P G  R+E
Sbjct: 602 PGPRPAGPAGDEPAES--PSET----PGPRPAGPAGDEPAES--PSETPGPSPAGPTRDE 653

Query: 511 PTPQAVATE 519
           P     A E
Sbjct: 654 PAKAGEAAE 662



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 47/130 (36%), Positives = 56/130 (43%), Gaps = 12/130 (9%)

Query: 391 PEKPSGEEPPVEAKREDGGPEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPP 450
           P  P+G+EP  E+  E  GP P G  PA      SP E  G    G P G  PAE+P   
Sbjct: 526 PAGPAGDEP-AESPSETPGPRPAG--PAGDEPAESPSETPGPRPAG-PAGDEPAESPSET 581

Query: 451 PPVEVKGEDGDQEPEGTLPAETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPPLGAAREE 510
           P     G   D+  E   P+ET    P  +  G  GD   E   P+E P P P G A +E
Sbjct: 582 PGPSPAGPTRDEPAES--PSET----PGPRPAGPAGDEPAES--PSETPGPRPAGPAGDE 633

Query: 511 PTPQAVATEG 520
           P      T G
Sbjct: 634 PAESPSETPG 643



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 56/190 (29%), Positives = 72/190 (37%), Gaps = 25/190 (13%)

Query: 334 RKRQRESQERGEMTSSDDGENVPASAEGKEEPPGDRETRQKMELFVKESFEAKD---ELC 390
           RKR++  +  G+  +   G     +  G   P G  +     E  V+E  E +    E  
Sbjct: 456 RKRRKVDEGAGDSAAVASGGAQTLALAGSPAPSGHPKAGHS-ENGVEEDTEGRTGPKEGT 514

Query: 391 PEKPSGEEPPVEAKREDGGPEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPP 450
           P  PS          E  GP P G  PA      SP E  G    G P G  PAE+P   
Sbjct: 515 PGSPS----------ETPGPSPAG--PAGDEPAESPSETPGPRPAG-PAGDEPAESPSET 561

Query: 451 PPVEVKGEDGDQEPEGTLPAETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPPLGAAREE 510
           P     G  GD+  E   P+ET   SP    + E  +       P+E P P P G A +E
Sbjct: 562 PGPRPAGPAGDEPAES--PSETPGPSPAGPTRDEPAES------PSETPGPRPAGPAGDE 613

Query: 511 PTPQAVATEG 520
           P      T G
Sbjct: 614 PAESPSETPG 623



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 48/207 (23%), Positives = 74/207 (35%), Gaps = 33/207 (15%)

Query: 336 RQRESQERGEMTSSDDGENVPASAEGKEEPPGDRETRQ-KMELFVKESFEAKDELCPEKP 394
           R  E Q+ G +  S  G+      E + EP   +E+++ K+EL  +E          + P
Sbjct: 348 RSVEPQDAGPLERSQ-GDEAGGHGEDRPEPLSPKESKKRKLELSRRE----------QPP 396

Query: 395 SGEEPPVEAKREDGGPEPEGTLPAETLLLSSPVEVKGED-GDG-----EPEGTLPAEAPP 448
           +   P   ++ E      EG   ++  L +   EV G+D G+      +P G   A+   
Sbjct: 397 TEPGPQSASEVEKIALNLEGCALSQGSLRTGTQEVGGQDPGEAVQPCRQPLGARVADKVR 456

Query: 449 PPPPVEVKGEDGDQEPEGTLPAETLLLSPPVK---------------VKGEDGDREPEGT 493
               V+    D      G      L  SP                   +G  G +E    
Sbjct: 457 KRRKVDEGAGDSAAVASGGAQTLALAGSPAPSGHPKAGHSENGVEEDTEGRTGPKEGTPG 516

Query: 494 LPAEAPPPPPLGAAREEPTPQAVATEG 520
            P+E P P P G A +EP      T G
Sbjct: 517 SPSETPGPSPAGPAGDEPAESPSETPG 543


>gi|53828918 Rab geranylgeranyltransferase alpha [Homo sapiens]
          Length = 567

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 45/132 (34%), Positives = 72/132 (54%), Gaps = 8/132 (6%)

Query: 131 LRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIEN 190
           LR  +L  N + K+E      E+R L L    L  + +LE L  +  L+LS+N ++T+  
Sbjct: 425 LRSKFLLENSVLKME----YAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPP 480

Query: 191 -LSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRV 249
            L+ L  L  LQ + N +E+++ + +L    RL  L L +N+L  P +L  L S P L +
Sbjct: 481 ALAALRCLEVLQASDNAIESLDGVTNLP---RLQELLLCNNRLQQPAVLQPLASCPRLVL 537

Query: 250 LNLMGNPVIRQI 261
           LNL GNP+ + +
Sbjct: 538 LNLQGNPLCQAV 549



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 38/122 (31%), Positives = 63/122 (51%), Gaps = 3/122 (2%)

Query: 127 EYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIEN-LEPLQKLDALNLSNNYI 185
           EY  +R L L    +  + +LE    +  L L  N LR +   L  L+ L+ L  S+N I
Sbjct: 439 EYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAI 498

Query: 186 KTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMP 245
           ++++ ++ LP L  L + +N L+    +Q L  C RL +L+L  N L   + + ILE + 
Sbjct: 499 ESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPLC--QAVGILEQLA 556

Query: 246 DL 247
           +L
Sbjct: 557 EL 558


>gi|33469951 Rab geranylgeranyltransferase alpha [Homo sapiens]
          Length = 567

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 45/132 (34%), Positives = 72/132 (54%), Gaps = 8/132 (6%)

Query: 131 LRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIEN 190
           LR  +L  N + K+E      E+R L L    L  + +LE L  +  L+LS+N ++T+  
Sbjct: 425 LRSKFLLENSVLKME----YAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPP 480

Query: 191 -LSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRV 249
            L+ L  L  LQ + N +E+++ + +L    RL  L L +N+L  P +L  L S P L +
Sbjct: 481 ALAALRCLEVLQASDNAIESLDGVTNLP---RLQELLLCNNRLQQPAVLQPLASCPRLVL 537

Query: 250 LNLMGNPVIRQI 261
           LNL GNP+ + +
Sbjct: 538 LNLQGNPLCQAV 549



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 38/122 (31%), Positives = 63/122 (51%), Gaps = 3/122 (2%)

Query: 127 EYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIEN-LEPLQKLDALNLSNNYI 185
           EY  +R L L    +  + +LE    +  L L  N LR +   L  L+ L+ L  S+N I
Sbjct: 439 EYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAI 498

Query: 186 KTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMP 245
           ++++ ++ LP L  L + +N L+    +Q L  C RL +L+L  N L   + + ILE + 
Sbjct: 499 ESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPLC--QAVGILEQLA 556

Query: 246 DL 247
           +L
Sbjct: 557 EL 558


>gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member A [Homo sapiens]
          Length = 249

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 58/227 (25%), Positives = 104/227 (45%), Gaps = 14/227 (6%)

Query: 165 KIENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLC 223
           K+E L +  ++L+ L+  N  + +I NL  L  L  L+++ N +    ++   ++C  L 
Sbjct: 33  KLEGLTDEFEELEFLSTINVGLTSIANLPKLNKLKKLELSDNRVSGGLEVL-AEKCPNLT 91

Query: 224 VLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLD--DR 281
            L+LS NK+ D   +  L+ + +L+ L+L  N  +  + +YR  V   L  LTYLD  DR
Sbjct: 92  HLNLSGNKIKDLSTIEPLKKLENLKSLDLF-NCEVTNLNDYRENVFKLLPQLTYLDGYDR 150

Query: 282 PVFPKDRACAEAWARGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQ 341
                  + AE +  G    E++E ++    + + + D        ++  +E +   E  
Sbjct: 151 DDKEAPDSDAEGYVEGLDDEEEDEDEEEYDEDAQVVED--------EEDEDEEEEGEEED 202

Query: 342 ERGEMTSSDDGEN-VPASAEGKEEPPGDRETRQKMELFVKESFEAKD 387
             GE    ++G N      E  EE  G+ E  QK +   ++  E  D
Sbjct: 203 VSGEEEEDEEGYNDGEVDDEEDEEELGEEERGQKRKREPEDEGEDDD 249


>gi|4503743 flightless I homolog [Homo sapiens]
          Length = 1269

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 55/140 (39%), Positives = 75/140 (53%), Gaps = 14/140 (10%)

Query: 145 ENLEAQTELRCLFLQMNLLRKI-ENLEPLQKLDALNLSNNYIKTIE-NLSCLPVLNTLQM 202
           EN++A T LR L L    L  + E L  LQKL+ L++S+N + T+   LS LP L  +  
Sbjct: 27  ENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVA 86

Query: 203 AHNHLE---TVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIR 259
             N L+     +DI  L +   L VLDLSHN+L+  E    LE+  ++ VLNL  N  I 
Sbjct: 87  RANSLKNSGVPDDIFKLDD---LSVLDLSHNQLT--ECPRELENAKNMLVLNLSHNS-ID 140

Query: 260 QIPNYRRTVTVRLKHLTYLD 279
            IPN    + + L  L YLD
Sbjct: 141 TIPN---QLFINLTDLLYLD 157


>gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member B [Homo sapiens]
          Length = 251

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 62/248 (25%), Positives = 107/248 (43%), Gaps = 31/248 (12%)

Query: 165 KIENLEP-LQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLC 223
           KIE L      L+ L+L N  + ++ NL  LP L  L+++ N +    D+   ++   L 
Sbjct: 33  KIEGLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELSENRIFGGLDML-AEKLPNLT 91

Query: 224 VLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPV 283
            L+LS NKL D   L  L+ +  L+ L+L  N  +  + +YR +V   L  LTYLD    
Sbjct: 92  HLNLSGNKLKDISTLEPLKKLECLKSLDLF-NCEVTNLNDYRESVFKLLPQLTYLD---- 146

Query: 284 FPKDRACAEAWARGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQER 343
                         GY  E +E    ++         ++ +   ++  E    + E  E 
Sbjct: 147 --------------GYDREDQEAPDSDAE--------VDGVDEEEEDEEGEDEEDEDDED 184

Query: 344 GEMTSSDDGENVPASAEGKEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEA 403
           GE    D+ ++     EG E+   D  + ++ E  + E  E +DE   E+  G+    + 
Sbjct: 185 GEEEEFDEEDDEDEDVEGDED--DDEVSEEEEEFGLDEEDEDEDEDEEEEEGGKGEKRKR 242

Query: 404 KREDGGPE 411
           + +D G +
Sbjct: 243 ETDDEGED 250


>gi|31377705 centrosomal protein 97kDa [Homo sapiens]
          Length = 865

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 56/217 (25%), Positives = 88/217 (40%), Gaps = 48/217 (22%)

Query: 124 NLEEYTGLRCLWLQSNGIQKIENLE----------------------AQTELRCLFLQMN 161
           NL     +  L L  N I K+ENLE                        T LR L L  N
Sbjct: 31  NLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHN 90

Query: 162 LLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQE--- 218
            +  +E L+ L  L+ LNL+ N +K +E ++    L  L ++ N++  + D+  L     
Sbjct: 91  SIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKT 150

Query: 219 ---------CLR---------LCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQ 260
                     LR         L +L L+ N++ D   +S L S+ +L  L++M NP +  
Sbjct: 151 LLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVMA 210

Query: 261 IP-----NYRRTVTVRLKHLTYLDDRPVFPKDRACAE 292
            P     +YR  +     +L  LD   +  K+   AE
Sbjct: 211 TPSIPGFDYRPYIVSWCLNLRVLDGYVISQKESLKAE 247


>gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member E isoform 1 [Homo sapiens]
          Length = 268

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 58/246 (23%), Positives = 112/246 (45%), Gaps = 30/246 (12%)

Query: 165 KIENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLC 223
           +IE L +  ++L+ L+++N  + ++  L  L  L  L+++ N +    ++   ++C  L 
Sbjct: 33  EIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVL-AEKCPNLT 91

Query: 224 VLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPV 283
            L+LS NK+ D   +  L+++ +L+ L+L  N  I  + +YR ++   L+ +TYLD    
Sbjct: 92  YLNLSGNKIKDLSTVEALQNLKNLKSLDLF-NCEITNLEDYRESIFELLQQITYLDG--- 147

Query: 284 FPKDRACAEAWARGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQER 343
           F ++            A + EE    +  E  +  +  EA        EE + + E ++ 
Sbjct: 148 FDQE---------DNEAPDSEEEDDEDGDEDDEEEEENEAGPPEGYEEEEEEEEEEDEDE 198

Query: 344 GEMTSSDDGENVPASAEGKEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEA 403
            E    D+ E      EG+EE          +   +KE  + +++       GEE   E 
Sbjct: 199 DE----DEDEAGSELGEGEEE--------VGLSYLMKEEIQDEEDDDDYVEEGEE---EE 243

Query: 404 KREDGG 409
           + E+GG
Sbjct: 244 EEEEGG 249


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 59/227 (25%), Positives = 87/227 (38%), Gaps = 34/227 (14%)

Query: 303 KEERQQWESRERKKIT-DSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAEG 361
           + ER + E  ER+++  + +E   + ++R E+ + +RE QER      +  E +      
Sbjct: 157 ERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERL 216

Query: 362 KEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEAKREDGGPEPEGTLPAETL 421
           + +   DRE +++ E    E  E + +    +   E   +E +RE            ET 
Sbjct: 217 ERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETP 276

Query: 422 LLSSPVEVKGEDGDGEP---EGTLPAE------------APPPPPPVEVKGEDGDQEPEG 466
           L S    V G+    EP     + PAE            APPPPPP+          P G
Sbjct: 277 LNS----VLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPL----------PPG 322

Query: 467 TLPAETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPPLGAAREEPTP 513
              A   L  PP    G         T P   PPPPPL      P P
Sbjct: 323 PAQASVALPPPP----GPPPPPPLPSTGPPPPPPPPPLPNQVPPPPP 365



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 70/274 (25%), Positives = 106/274 (38%), Gaps = 37/274 (13%)

Query: 236 EILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWA 295
           E+L+  E+ P L   N      ++  P+ +  + ++ + L     +    ++R   E   
Sbjct: 109 EVLNSQETGPTLPRQNSQLPAQVQNGPS-QEELEIQRRQLQEQQRQKELERERLERERME 167

Query: 296 RGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAE--ERKRQRESQERGEMTSSDDGE 353
           R     E+ ER++ E RER +  + +E     ++R E  ER+ + E QER E     D E
Sbjct: 168 RERLERERLERERLE-RERLE-QEQLERERQERERQERLERQERLERQERLERQERLDRE 225

Query: 354 NVP-ASAEGKEEPPGDRETRQKMELFVKESFEAKDE---LCPEKPSGEEPPVEAKREDGG 409
                  E  E    +R+ R++ E   +E  E + E        P+  E P+ +   D  
Sbjct: 226 RQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSS 285

Query: 410 PEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPPVEVKGEDGDQEPEGTLP 469
               G   A     S P E   + G       L   APPPPPP+          P G   
Sbjct: 286 ASEPGLQAA-----SQPAETPSQQGI-----VLGPLAPPPPPPL----------PPGPAQ 325

Query: 470 AETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPP 503
           A   L  PP           P   LP+  PPPPP
Sbjct: 326 ASVALPPPP--------GPPPPPPLPSTGPPPPP 351



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 44/163 (26%), Positives = 64/163 (39%), Gaps = 22/163 (13%)

Query: 302 EKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAEG 361
           E+ ERQ+   RER++  +  E L  +++  +ER+RQ E  ER ++    +     A+A  
Sbjct: 214 ERLERQERLDRERQERQER-ERLERLERERQERERQ-EQLEREQLEWERERRISSAAAPA 271

Query: 362 KEEPP-----GDRETRQKMELFVKESFEAKDE-------LCPEKPSGEEPPVEAKREDGG 409
             E P     GD    +       +  E   +       L P  P    PP  A+     
Sbjct: 272 SVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPP-PLPPGPAQASVAL 330

Query: 410 PEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPP 452
           P P G  P   L  + P           P   LP + PPPPPP
Sbjct: 331 PPPPGPPPPPPLPSTGPPPPP-------PPPPLPNQVPPPPPP 366



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 42/164 (25%), Positives = 65/164 (39%), Gaps = 18/164 (10%)

Query: 302 EKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAEG 361
           E++ER++ E  ER++  +  E L   ++R +  +++R+ +ER E    +  E        
Sbjct: 194 ERQERERQERLERQERLERQERLER-QERLDRERQERQERERLERLERERQERERQEQLE 252

Query: 362 KEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEP-------PVEAKREDG------ 408
           +E+   +RE R+        S E          S  EP       P E   + G      
Sbjct: 253 REQLEWERE-RRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPL 311

Query: 409 GPEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPP 452
            P P   LP      S  V +    G   P   LP+  PPPPPP
Sbjct: 312 APPPPPPLPPGPAQAS--VALPPPPGPPPPP-PLPSTGPPPPPP 352


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 59/227 (25%), Positives = 87/227 (38%), Gaps = 34/227 (14%)

Query: 303 KEERQQWESRERKKIT-DSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAEG 361
           + ER + E  ER+++  + +E   + ++R E+ + +RE QER      +  E +      
Sbjct: 157 ERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERL 216

Query: 362 KEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEAKREDGGPEPEGTLPAETL 421
           + +   DRE +++ E    E  E + +    +   E   +E +RE            ET 
Sbjct: 217 ERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETP 276

Query: 422 LLSSPVEVKGEDGDGEP---EGTLPAE------------APPPPPPVEVKGEDGDQEPEG 466
           L S    V G+    EP     + PAE            APPPPPP+          P G
Sbjct: 277 LNS----VLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPL----------PPG 322

Query: 467 TLPAETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPPLGAAREEPTP 513
              A   L  PP    G         T P   PPPPPL      P P
Sbjct: 323 PAQASVALPPPP----GPPPPPPLPSTGPPPPPPPPPLPNQVPPPPP 365



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 70/274 (25%), Positives = 106/274 (38%), Gaps = 37/274 (13%)

Query: 236 EILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWA 295
           E+L+  E+ P L   N      ++  P+ +  + ++ + L     +    ++R   E   
Sbjct: 109 EVLNSQETGPTLPRQNSQLPAQVQNGPS-QEELEIQRRQLQEQQRQKELERERLERERME 167

Query: 296 RGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAE--ERKRQRESQERGEMTSSDDGE 353
           R     E+ ER++ E RER +  + +E     ++R E  ER+ + E QER E     D E
Sbjct: 168 RERLERERLERERLE-RERLE-QEQLERERQERERQERLERQERLERQERLERQERLDRE 225

Query: 354 NVP-ASAEGKEEPPGDRETRQKMELFVKESFEAKDE---LCPEKPSGEEPPVEAKREDGG 409
                  E  E    +R+ R++ E   +E  E + E        P+  E P+ +   D  
Sbjct: 226 RQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSS 285

Query: 410 PEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPPVEVKGEDGDQEPEGTLP 469
               G   A     S P E   + G       L   APPPPPP+          P G   
Sbjct: 286 ASEPGLQAA-----SQPAETPSQQGI-----VLGPLAPPPPPPL----------PPGPAQ 325

Query: 470 AETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPP 503
           A   L  PP           P   LP+  PPPPP
Sbjct: 326 ASVALPPPP--------GPPPPPPLPSTGPPPPP 351



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 44/163 (26%), Positives = 64/163 (39%), Gaps = 22/163 (13%)

Query: 302 EKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAEG 361
           E+ ERQ+   RER++  +  E L  +++  +ER+RQ E  ER ++    +     A+A  
Sbjct: 214 ERLERQERLDRERQERQER-ERLERLERERQERERQ-EQLEREQLEWERERRISSAAAPA 271

Query: 362 KEEPP-----GDRETRQKMELFVKESFEAKDE-------LCPEKPSGEEPPVEAKREDGG 409
             E P     GD    +       +  E   +       L P  P    PP  A+     
Sbjct: 272 SVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPP-PLPPGPAQASVAL 330

Query: 410 PEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPP 452
           P P G  P   L  + P           P   LP + PPPPPP
Sbjct: 331 PPPPGPPPPPPLPSTGPPPPP-------PPPPLPNQVPPPPPP 366



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 42/164 (25%), Positives = 65/164 (39%), Gaps = 18/164 (10%)

Query: 302 EKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAEG 361
           E++ER++ E  ER++  +  E L   ++R +  +++R+ +ER E    +  E        
Sbjct: 194 ERQERERQERLERQERLERQERLER-QERLDRERQERQERERLERLERERQERERQEQLE 252

Query: 362 KEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEP-------PVEAKREDG------ 408
           +E+   +RE R+        S E          S  EP       P E   + G      
Sbjct: 253 REQLEWERE-RRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPL 311

Query: 409 GPEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPP 452
            P P   LP      S  V +    G   P   LP+  PPPPPP
Sbjct: 312 APPPPPPLPPGPAQAS--VALPPPPGPPPPP-PLPSTGPPPPPP 352


>gi|157738619 smoothelin-like 1 [Homo sapiens]
          Length = 512

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 57/243 (23%), Positives = 90/243 (37%), Gaps = 37/243 (15%)

Query: 302 EKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAEG 361
           E   R++    E K+  +    LA  KQ+AEE++ + ES ++ +    D  E      E 
Sbjct: 128 EMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEE 187

Query: 362 KEEPPGDRETRQKMELFVKESFEAKDELC----------------PEKPSGEEPPVEAKR 405
             +     ET Q+ E   +   +A DE                  P++P G+E      +
Sbjct: 188 DAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAK 247

Query: 406 EDGGPEPEGTLPAETLLLSSPVEVKGEDGDGEPEG------TLPAEAPPPP--------- 450
           E+   + E    AE     SP E + +D + EPEG      + P E P  P         
Sbjct: 248 EEADAKEEAE-DAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLST 306

Query: 451 ----PPVEVKGEDGDQEPEGTLPAETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPPLGA 506
               P     G+      E + P++     P     GE  ++ PE  + A A P  P   
Sbjct: 307 DGLGPDCVASGQTSPSASESS-PSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQ 365

Query: 507 ARE 509
            R+
Sbjct: 366 NRK 368



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 53/225 (23%), Positives = 83/225 (36%), Gaps = 28/225 (12%)

Query: 287 DRACAEAWARGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEM 346
           D    E+    G   + E   + E  E+++ T   + +     R EE K + +  E  E 
Sbjct: 92  DEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMT---GRKEETKSEPKEAEEKES 148

Query: 347 TSSDDGENVPASAEGKEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEAKRE 406
           T + + +     AE KE  P   E+ QK +   ++  E K  +  E           +R+
Sbjct: 149 TLASEKQK----AEEKEAKP---ESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRK 201

Query: 407 DGGPEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPPVEVK---GEDGDQE 463
           +   EP+     E        E K E      E    AE   P    E K    E+ D +
Sbjct: 202 ECSTEPKEKATDE--------EAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAK 253

Query: 464 PEGTLPAETLLLSPPVKVKGEDGDREPEG------TLPAEAPPPP 502
            E    AE      P + + +D ++EPEG      + P E P  P
Sbjct: 254 EEAE-DAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESP 297


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 98/470 (20%), Positives = 162/470 (34%), Gaps = 82/470 (17%)

Query: 285  PKDRACAEAWARGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERG 344
            P+    A+  + G  A E E   Q    E +  ++ +EA           + + E+Q   
Sbjct: 1838 PEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEA----------PEAEGEAQPES 1887

Query: 345  EMTSSDDGE-NVPASAEGKEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEA 403
            E   + + E  V   +EG E P  ++E + + E       E +DE   E    +E    A
Sbjct: 1888 EDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAA 1947

Query: 404  KREDGGPEPEGTL-------------PAETLLLSSPVEVKGEDGDGEPEG---------- 440
            +  +G  +PE  +               +   L   VE +  +G+ +PE           
Sbjct: 1948 QEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEG 2007

Query: 441  ---TLPAEAPPPPPPV------------EVKGE----DGDQEPEG----TLPAETLLLSP 477
                   EA P    V            EV+GE    +GD +PE        AE      
Sbjct: 2008 EMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEA 2067

Query: 478  PVKVKGEDGDREPEG------TLPAEAPPPPPLGAAREEPTPQAVATEGVFVTELDGTRT 531
              +V+  +G+  PE           EA P    G    E   +A   EG+   E +G   
Sbjct: 2068 EGEVQEAEGEAHPESEDVDAQEAEGEAQPESE-GVEAPEAEGEAQKAEGIEAPETEGEAQ 2126

Query: 532  EDLETIRLETKETFCIDDLPDLEDDDETGKSLEDQNMCFPKIEVISS--LSDDSDPELDY 589
             + E I     E     +   +E  D  G++        P+ E I +    +++ PEL+ 
Sbjct: 2127 PESEGIEAPEAEGEAQPESEGVEAQDAEGEAQ-------PESEGIEAQEAEEEAQPELEG 2179

Query: 590  TSLPVLENLPTDTLSNIFAVSKDTSKAARVPFTDIFKKEAKRDLEIRKQDTKSPRPLIQE 649
               P  E         I A   +      +   +  + E +   E    +T       Q 
Sbjct: 2180 VEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQP 2239

Query: 650  LSDEDPSGQLLMPPTCQRDAAPLTSSGDRDSDFLA-ASSPVPTESAATPP 698
             S+ +  G        ++  +P  S GD  S+  + +SSPVP +    PP
Sbjct: 2240 ESEGETQG--------EKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPP 2281



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 87/431 (20%), Positives = 153/431 (35%), Gaps = 58/431 (13%)

Query: 302  EKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAEG 361
            E E     + RE K       A + + +  +E +   E  E G   S  +      +A G
Sbjct: 1762 EAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAG 1821

Query: 362  KEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVE--AKREDGGPEPEGTLPAE 419
             ++ PG  +  + +     E+ EA+ E  PE    E P  E  A+  +G  +PE      
Sbjct: 1822 GDQDPGQSDGAEGI-----EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPE------ 1870

Query: 420  TLLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPPVEVKGE-DGDQEPEGTLPAETLLLSPP 478
                S  VE    +G+ +PE     +   P    EV+ E +G + PE    A+    S  
Sbjct: 1871 ----SEDVEAPEAEGEAQPES---EDVETPEAEWEVQPESEGAEAPEAEKEAQPETES-- 1921

Query: 479  VKVKGEDGDREPEGTLPAEAPPPPPLGAAREEPTPQAVATEGVFVTELDGTRTEDLETIR 538
            V+    +G+ EPE               A  +  P++   E     E     +ED+E + 
Sbjct: 1922 VEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALE 1981

Query: 539  LETK----ETFCIDDLPDLEDDDETGKSLEDQNMCFPKIEVISS---------------- 578
            +E +    E     +  D+E  +  G+  E +    P+ + + +                
Sbjct: 1982 VEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGET 2041

Query: 579  --LSDDSDPELDYTSLPVLENLPTDTLSNIFAVSKDTSKAARVPFTDIFKKEAKRDLEIR 636
                 D+ PE D    P  E    +    +    ++    A     D+  +EA+ + +  
Sbjct: 2042 QKTEGDAQPESDGVEAPEAEEEAQEAEGEV----QEAEGEAHPESEDVDAQEAEGEAQPE 2097

Query: 637  KQDTKSPRPLIQELSDEDPSGQLLMPPTCQRDAAPLTSSGDRDSDFLAASSPVPTESAAT 696
             +  ++P     E   E    + +  P  + +A P  S G    +    + P   ES   
Sbjct: 2098 SEGVEAP-----EAEGEAQKAEGIEAPETEGEAQP-ESEGIEAPEAEGEAQP---ESEGV 2148

Query: 697  PPETCVGVAQP 707
              +   G AQP
Sbjct: 2149 EAQDAEGEAQP 2159



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 61/239 (25%), Positives = 89/239 (37%), Gaps = 36/239 (15%)

Query: 282  PVFPKDRACAEAWARGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRES- 340
            P F   RACA A        ++ ER   E R    +    E     + + EE K   E  
Sbjct: 1259 PTFLNARACACATNE-----DEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGE 1313

Query: 341  --QERG---EMTSSDDG---ENVPASAEGKEEPPGDRETRQKMELFVKESFEAKDELCPE 392
              QE     E T +++G   E V      + E  G +E   ++E   +   E   E   +
Sbjct: 1314 GLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQ 1373

Query: 393  KPSGEEPPV---------EAKREDGGPEPEGTLPAETLLLSSPVEVKG--EDGDGEPEGT 441
                +E P          E  +E+G P  EG++  + L  +S  + KG  ED   + E  
Sbjct: 1374 LEEVKEGPEGGLQGEALEEGLKEEGLP-EEGSVHGQELSEASSPDGKGSQEDDPVQEEEA 1432

Query: 442  LPAEAPPPPPPVEVKGEDGDQEPEGTLPAETLLLSPPVKVKGEDGDREPEGTLPAEAPP 500
              A A   P P E     G +EP  T P   L  + P   + + G +   G    E PP
Sbjct: 1433 GRASASAEPCPAE-----GTEEP--TEPPSHLSETDPSASERQSGSQLEPG---LEKPP 1481


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 77/305 (25%), Positives = 125/305 (40%), Gaps = 54/305 (17%)

Query: 288 RACAEAWARGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMT 347
           +A  EA A+     E+EERQ+ E  ER K  + +EA    ++R E+ KR+R+ Q+  E  
Sbjct: 342 KAMQEALAK---LKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERK 398

Query: 348 SSDDGENVPASAEGKEEPPGDRETRQKMELFVK------ESFEAKDELCPEKPSGEEPPV 401
                       EGK      RE R + E  +K          +KD L  ++P  E    
Sbjct: 399 ER-------LKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYE---- 447

Query: 402 EAKREDGGPEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPPVEVKGEDGD 461
           + KR+    + E    +E++ L + VEV  E G  E E T        PPPVE + E+ D
Sbjct: 448 DKKRKKIPQQLESKEVSESMELCAAVEVM-EQGVPEKEET--------PPPVEPE-EEED 497

Query: 462 QEPEGTLPAETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPPLGAAREEPTPQAVATEGV 521
            E  G    E +          E+ ++     +  E    P      EE           
Sbjct: 498 TEDAGLDDWEAM-------ASDEETEKVEGNKVHIEVKENPEEEEEEEE----------- 539

Query: 522 FVTELDGTRTEDLETIRLETKETFCIDDLPDLEDDDETGKSLEDQNMCFPKIEVISSLSD 581
              E +   +E+ E    E++ +   ++   + D+ ++GK+L+ +    P  E+ S    
Sbjct: 540 --EEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKK----PSKEMSSDSEY 593

Query: 582 DSDPE 586
           DSD +
Sbjct: 594 DSDDD 598



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 73/336 (21%), Positives = 135/336 (40%), Gaps = 42/336 (12%)

Query: 302 EKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAEG 361
           EKEE+++ + +   K T      A+ K + EE +++RE +ER                + 
Sbjct: 324 EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEER---------------IKR 368

Query: 362 KEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEAKREDGGPEPEGTLPAETL 421
            EE    R+  +++E   +E  + K++   E+   E   +   + +     E TL    L
Sbjct: 369 LEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATL---KL 425

Query: 422 LLSSPVEVKGEDGDGEPEGTLPAEAPPPPPPVEVKGEDGDQEPEGTLPAETLLLSPPVKV 481
           L +  VEV  +D       +LP + P      + K +   Q+ E    +E++ L   V+V
Sbjct: 426 LQAQGVEVPSKD-------SLPKKRPIYE---DKKRKKIPQQLESKEVSESMELCAAVEV 475

Query: 482 KGEDGDREPEGTLPAEAPPPPPLGAAREEPTPQAVATEGVFVTELDGTRTEDLETIRLET 541
             E G  E E T       PPP+    EE T  A   +   +   + T   +   + +E 
Sbjct: 476 M-EQGVPEKEET-------PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEV 527

Query: 542 KETFCIDDLPDLEDDDETGKSLEDQNMCFPKIEVISSLSDDSDPELDYTSLPVLENLPTD 601
           KE    ++  + E+++E  +  E++     + E      +D     +  S   L+  P+ 
Sbjct: 528 KEN--PEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSK 585

Query: 602 TLSNIFAVSKDTSKAARVPFTDIFKKEAKRDLEIRK 637
            +S+      D  +       D    +AKR +E R+
Sbjct: 586 EMSSDSEYDSDDDRTKEERAYD----KAKRRIEKRR 617


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 59/233 (25%), Positives = 90/233 (38%), Gaps = 23/233 (9%)

Query: 301 AEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAE 360
           +EKE     E  E  ++T+ +      ++  E ++ + + +E GE   ++ GE    S  
Sbjct: 450 SEKETVIVEEQTEETQVTEEVTE----EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPP 505

Query: 361 GKEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEP-----PVEAK---REDGGPEP 412
            +E    ++E +  ++   K   EAK    PEK   + P     P +AK   +E+    P
Sbjct: 506 AEEAASPEKEAKSPVKEEAKSPAEAKS---PEKEEAKSPAEVKSPEKAKSPAKEEAKSPP 562

Query: 413 EGTLPAETLLLSSPVEVKGEDGDGEP---EGTLPAEAPPPPPPVEVKGEDGDQEPEGTLP 469
           E   P E     SP EVK  +    P   E   PAEA  P        E+     E   P
Sbjct: 563 EAKSP-EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSP 621

Query: 470 AETLLLSPPVKVKGEDGDREP---EGTLPAEAPPPPPLGAAREEPTPQAVATE 519
            +    S P +VK  +  + P   E   P +A  P    A   E     V  E
Sbjct: 622 VKEEAKS-PAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE 673



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 53/223 (23%), Positives = 91/223 (40%), Gaps = 26/223 (11%)

Query: 310 ESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAEGKEEPPGDR 369
           +S  ++++    +A + +K+ A  +  ++E  ++ E+ S    E  P   + KE P    
Sbjct: 786 KSPVKEEVKSPEKAKSPLKEDA--KAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAE 843

Query: 370 ETRQKMELFVKESFEAKDELCPEKPSGEEPPVEAKREDGGPEPEGTLPAETLLLSSPVEV 429
           E +       +E  ++K E  P+K    +P VE K+E    +P+           S VE 
Sbjct: 844 EEKAPATPKTEEKKDSKKEEAPKK-EAPKPKVEEKKEPAVEKPK----------ESKVEA 892

Query: 430 KGEDGDGE-----PEGTLPAEA-------PPPPPPVEVKGEDGDQEPEGTLPAETLLLSP 477
           K E+ + +     PE   PA+        P     V  K  D  +  E + PAE    +P
Sbjct: 893 KKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAP 952

Query: 478 PVKVKGEDGDREPEGTLPAEAPPPPPLGAAREEPT-PQAVATE 519
             K   E+  ++PE     EA          +EP+ P+A   E
Sbjct: 953 EKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAE 995



 Score = 33.5 bits (75), Expect = 0.71
 Identities = 71/369 (19%), Positives = 133/369 (36%), Gaps = 30/369 (8%)

Query: 295 ARGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGEN 354
           A+    A+  E+++ +S    K  +  ++ A  + ++    +  E +E          E 
Sbjct: 524 AKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEK 583

Query: 355 VPASAEGKEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEE--PPVEAKREDGGPEP 412
             + A+ + + P + ++ +K +  VKE  EAK     + P  EE   P E K  +    P
Sbjct: 584 AKSPAKEEAKSPAEAKSPEKAKSPVKE--EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641

Query: 413 EGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPP-----PPPVEVKGEDGDQEPEGT 467
                       SP + + +  + + +  + AEA  P     P   E K  +  + P   
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPE-KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKE 700

Query: 468 LPAETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPPLGAAREEPTPQAVATEGVFVTELD 527
                     PVK + +  ++           P       +EE      A        LD
Sbjct: 701 EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD 760

Query: 528 GTRTEDLETIRLETKETFCIDDLPDLEDDDETGKSLEDQNMCFPKIEVISSLSDDSD--- 584
               E     + E +     D  P      E  KS   + +  P+ +  S L +D+    
Sbjct: 761 VKSPEAKTPAKEEARSP--ADKFP------EKAKSPVKEEVKSPE-KAKSPLKEDAKAPE 811

Query: 585 ---PELDYTSLPVL-ENLPTDTLSNIFAVSKDTSKAARVPFTDIFKKEAKRDLEIRKQDT 640
              P+ +    PV  E  P +          +  KA   P T+  KK++K++   +K+  
Sbjct: 812 KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE-EKKDSKKEEAPKKE-- 868

Query: 641 KSPRPLIQE 649
            +P+P ++E
Sbjct: 869 -APKPKVEE 876


>gi|164607156 axonemal dynein light chain 1 [Homo sapiens]
          Length = 190

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 51/174 (29%), Positives = 80/174 (45%), Gaps = 15/174 (8%)

Query: 126 EEYTGLRC-------LWLQSNGIQKIE-NLEAQTELRCLFLQMNLLRKIENLEPLQKLDA 177
           EE TG R        L+ Q   I+K++ +L        L L  N + KI NL  L+ L  
Sbjct: 15  EEKTGQRPSEAKEIKLYAQIPPIEKMDASLSMLANCEKLSLSTNCIEKIANLNGLKNLRI 74

Query: 178 LNLSNNYIKTIENLSCL-PVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPE 236
           L+L  N IK +  L  +   L  L +++N +E ++ I  ++   +L +L +S+N + D  
Sbjct: 75  LSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKLKGIHIMK---KLKILYMSNNLVKDWA 131

Query: 237 ILSILESMPDLRVLNLMGNPVIRQIP---NYRRTVTVRLKHLTYLDDRPVFPKD 287
               L  +P L  L  +GNP+  +     N+    T R+  L  LD  PV   D
Sbjct: 132 EFVKLAELPCLEDLVFVGNPLEEKHSAENNWIEEATKRVPKLKKLDGTPVIKGD 185


>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
          Length = 582

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 42/132 (31%), Positives = 75/132 (56%), Gaps = 9/132 (6%)

Query: 120 DRIENLEEYTGLRCLWLQSNGIQKIENLEAQTE-LRCLFLQMNLLRKIE-NLEPLQKLDA 177
           D ++NL++   LR L L+ N +++I ++  + + L  L+L+ N +  +E +++ L KL  
Sbjct: 163 DSLDNLKK---LRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSM 219

Query: 178 LNLSNNYIKTIE-NLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSD-P 235
           L++  N IK +   +  L  L TL +AHN LE +   + +  C ++  LDL HN+L D P
Sbjct: 220 LSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLP--KEIGNCTQITNLDLQHNELLDLP 277

Query: 236 EILSILESMPDL 247
           + +  L S+  L
Sbjct: 278 DTIGNLSSLSRL 289


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.131    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,328,980
Number of Sequences: 37866
Number of extensions: 2144985
Number of successful extensions: 19869
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 1075
Number of HSP's that attempted gapping in prelim test: 13050
Number of HSP's gapped (non-prelim): 5470
length of query: 725
length of database: 18,247,518
effective HSP length: 110
effective length of query: 615
effective length of database: 14,082,258
effective search space: 8660588670
effective search space used: 8660588670
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.