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Search of human proteins with 157674354
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157674354 WD repeat domain 72 [Homo sapiens]
(1102 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157674354 WD repeat domain 72 [Homo sapiens] 2242 0.0
gi|73747879 rabconnectin-3 beta isoform 2 [Homo sapiens] 605 e-173
gi|73747877 rabconnectin-3 beta isoform 1 [Homo sapiens] 602 e-172
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 51 5e-06
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 49 3e-05
gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens] 48 6e-05
gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens] 48 6e-05
gi|23199987 WD repeat domain 5B [Homo sapiens] 47 1e-04
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 47 1e-04
gi|21071067 TBP-associated factor 5 [Homo sapiens] 47 1e-04
gi|113865883 WD repeat domain 38 [Homo sapiens] 47 1e-04
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 46 2e-04
gi|55769546 PAK1 interacting protein 1 [Homo sapiens] 45 4e-04
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 45 4e-04
gi|221139921 EF-hand calcium binding domain 8 [Homo sapiens] 44 6e-04
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 44 6e-04
gi|16554629 WD repeat domain 5 [Homo sapiens] 44 8e-04
gi|16554627 WD repeat domain 5 [Homo sapiens] 44 8e-04
gi|32189425 WD repeat domain 69 [Homo sapiens] 44 8e-04
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 42 0.002
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 42 0.002
gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Ho... 42 0.002
gi|124028510 WD40-repeat protein upregulated in HCC isoform c [H... 42 0.002
gi|124028512 WD40-repeat protein upregulated in HCC isoform b [H... 42 0.002
gi|13376840 WD repeat domain 61 [Homo sapiens] 42 0.003
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 42 0.004
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 42 0.004
gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens] 42 0.004
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 42 0.004
gi|26665869 WD repeat domain 51B [Homo sapiens] 42 0.004
>gi|157674354 WD repeat domain 72 [Homo sapiens]
Length = 1102
Score = 2242 bits (5810), Expect = 0.0
Identities = 1102/1102 (100%), Positives = 1102/1102 (100%)
Query: 1 MRTSLQAVALWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFG 60
MRTSLQAVALWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFG
Sbjct: 1 MRTSLQAVALWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFG 60
Query: 61 HSASVTCLARARDFSKQPYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFR 120
HSASVTCLARARDFSKQPYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFR
Sbjct: 61 HSASVTCLARARDFSKQPYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFR 120
Query: 121 MTGEGWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSV 180
MTGEGWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSV
Sbjct: 121 MTGEGWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSV 180
Query: 181 AGELKVWDLSSSINSIQEKQDVYEKESKFLESLNCQTIRFCTYTERLLLVVFSKCWKVYD 240
AGELKVWDLSSSINSIQEKQDVYEKESKFLESLNCQTIRFCTYTERLLLVVFSKCWKVYD
Sbjct: 181 AGELKVWDLSSSINSIQEKQDVYEKESKFLESLNCQTIRFCTYTERLLLVVFSKCWKVYD 240
Query: 241 YCDFSLLLTEVSRNGQFFAGGEVIAAHRILIWTEDGHSYIYQLLNSGLSKSIYPADGRVL 300
YCDFSLLLTEVSRNGQFFAGGEVIAAHRILIWTEDGHSYIYQLLNSGLSKSIYPADGRVL
Sbjct: 241 YCDFSLLLTEVSRNGQFFAGGEVIAAHRILIWTEDGHSYIYQLLNSGLSKSIYPADGRVL 300
Query: 301 KETIYPHLLCSTSVQENKEQSRPFVMGYMNERKEPFYKVLFSGEVSGRITLWHIPDVPVS 360
KETIYPHLLCSTSVQENKEQSRPFVMGYMNERKEPFYKVLFSGEVSGRITLWHIPDVPVS
Sbjct: 301 KETIYPHLLCSTSVQENKEQSRPFVMGYMNERKEPFYKVLFSGEVSGRITLWHIPDVPVS 360
Query: 361 KFDGSPREIPVTATWTLQDNFDKHDTMSQSIIDYFSGLKDGAGTAVVTSSEYIPSLDKLI 420
KFDGSPREIPVTATWTLQDNFDKHDTMSQSIIDYFSGLKDGAGTAVVTSSEYIPSLDKLI
Sbjct: 361 KFDGSPREIPVTATWTLQDNFDKHDTMSQSIIDYFSGLKDGAGTAVVTSSEYIPSLDKLI 420
Query: 421 CGCEDGTIIITQALNAAKARLLEGGSLVKDSPPHKVLKGHHQSVTSLLYPHGLSSKLDQS 480
CGCEDGTIIITQALNAAKARLLEGGSLVKDSPPHKVLKGHHQSVTSLLYPHGLSSKLDQS
Sbjct: 421 CGCEDGTIIITQALNAAKARLLEGGSLVKDSPPHKVLKGHHQSVTSLLYPHGLSSKLDQS 480
Query: 481 WMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVA 540
WMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVA
Sbjct: 481 WMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVA 540
Query: 541 LLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERA 600
LLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERA
Sbjct: 541 LLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERA 600
Query: 601 RIILNCCDDSQLVKSVLPIASETLKHKSIEQRSSSPYQLGPLPCPGLQVESSCKVTDAKF 660
RIILNCCDDSQLVKSVLPIASETLKHKSIEQRSSSPYQLGPLPCPGLQVESSCKVTDAKF
Sbjct: 601 RIILNCCDDSQLVKSVLPIASETLKHKSIEQRSSSPYQLGPLPCPGLQVESSCKVTDAKF 660
Query: 661 CPRPFNVLPVKTKWSNVGFHILLFDLENLVELLLPTPLSDVDSSSSFYGGEVLRRAKSTV 720
CPRPFNVLPVKTKWSNVGFHILLFDLENLVELLLPTPLSDVDSSSSFYGGEVLRRAKSTV
Sbjct: 661 CPRPFNVLPVKTKWSNVGFHILLFDLENLVELLLPTPLSDVDSSSSFYGGEVLRRAKSTV 720
Query: 721 EKKTLTLRKSKTACGPLSAEALAKPITESLAQGDNTIKFSEENDGIKRQKKMKISKKMQP 780
EKKTLTLRKSKTACGPLSAEALAKPITESLAQGDNTIKFSEENDGIKRQKKMKISKKMQP
Sbjct: 721 EKKTLTLRKSKTACGPLSAEALAKPITESLAQGDNTIKFSEENDGIKRQKKMKISKKMQP 780
Query: 781 KPSRKVDASLTIDTAKLFLSCLLPWGVDKDLDYLCIKHLNILKLQGPISLGISLNEDNFS 840
KPSRKVDASLTIDTAKLFLSCLLPWGVDKDLDYLCIKHLNILKLQGPISLGISLNEDNFS
Sbjct: 781 KPSRKVDASLTIDTAKLFLSCLLPWGVDKDLDYLCIKHLNILKLQGPISLGISLNEDNFS 840
Query: 841 LMLPGWDLCNSGMIKDYSGVNLFSRKVLDLSDKYTATLPNQVGIPRGLENNCDSLRESDT 900
LMLPGWDLCNSGMIKDYSGVNLFSRKVLDLSDKYTATLPNQVGIPRGLENNCDSLRESDT
Sbjct: 841 LMLPGWDLCNSGMIKDYSGVNLFSRKVLDLSDKYTATLPNQVGIPRGLENNCDSLRESDT 900
Query: 901 IVYLLSRLFLVNKLVNMPLELACRVGSSFRMESIHNKMRGAGNDILNMSSFYSCLRNGKN 960
IVYLLSRLFLVNKLVNMPLELACRVGSSFRMESIHNKMRGAGNDILNMSSFYSCLRNGKN
Sbjct: 901 IVYLLSRLFLVNKLVNMPLELACRVGSSFRMESIHNKMRGAGNDILNMSSFYSCLRNGKN 960
Query: 961 ESHVPEADLSLLKLISCWRDQSVQVTEAIQAVLLAEVQQHMKSLGKIPVNSQPVSMAENG 1020
ESHVPEADLSLLKLISCWRDQSVQVTEAIQAVLLAEVQQHMKSLGKIPVNSQPVSMAENG
Sbjct: 961 ESHVPEADLSLLKLISCWRDQSVQVTEAIQAVLLAEVQQHMKSLGKIPVNSQPVSMAENG 1020
Query: 1021 NCEMKQMLPKLEWTEELELQCVRNTLPLQTPVSPVKHDSNSNSANFQDVEDMPDRCALEE 1080
NCEMKQMLPKLEWTEELELQCVRNTLPLQTPVSPVKHDSNSNSANFQDVEDMPDRCALEE
Sbjct: 1021 NCEMKQMLPKLEWTEELELQCVRNTLPLQTPVSPVKHDSNSNSANFQDVEDMPDRCALEE 1080
Query: 1081 SESPGEPRHHSWIAKVCPCKVS 1102
SESPGEPRHHSWIAKVCPCKVS
Sbjct: 1081 SESPGEPRHHSWIAKVCPCKVS 1102
>gi|73747879 rabconnectin-3 beta isoform 2 [Homo sapiens]
Length = 1457
Score = 605 bits (1561), Expect = e-173
Identities = 365/1034 (35%), Positives = 588/1034 (56%), Gaps = 81/1034 (7%)
Query: 8 VALWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTC 67
+ LWG+KAP H I+A+++TDD TIVTG +GQ+CLW+LS EL+I+ + LLFGH+AS+TC
Sbjct: 10 IVLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITC 69
Query: 68 LARARDFSKQPYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEGWL 127
L++A S + YIVSA+E+GEMC+W+V++G+C+E L HT I +Y S EG L
Sbjct: 70 LSKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFSVGNQREGRL 129
Query: 128 LCCGEYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVAGELKVW 187
LC G Y ++L++DA +L V++S S PDWI+ M I+ S R QED+++ +SV G LKVW
Sbjct: 130 LCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVW 189
Query: 188 DLSSSINSIQEKQDVYEKESKFLESLNCQTIRFCTYTERLLLVVFSKCWKVYDYCDFSLL 247
++S I+ +Q+ + ++E+ESK + NCQ+I FC +T+R LLVV SK W+V+D D+SLL
Sbjct: 190 IVTSEISDMQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLL 249
Query: 248 LTEVSRNGQFFAGGEVIAAHRILIWTEDGHSYIYQLLNSGL--SKSIYPADGRVLKETIY 305
+ S NGQ + GG+ +++ +++IWTE+G SYIY+L S L S S G+ ++ I
Sbjct: 250 CSGPSENGQTWTGGDFVSSDKVIIWTENGQSYIYKLPASCLPASDSFRSDVGKAVENLIP 309
Query: 306 P--HLLCSTSVQENKEQSRPFVMGYMNERKEPFYKVLFSGEVSGRITLWHIPDVPVSKFD 363
P H+L ++ + P V + +E F+K+L G+ SGR+ +W+I D +
Sbjct: 310 PVQHILLDR--KDKELLICPPVTRFFYGCREYFHKLLIQGDSSGRLNIWNISD--TADKQ 365
Query: 364 GSPREIPVTATWTLQDNFDKHDTMSQSIIDYFSGLKDGAGTAVVTSSEYIPSLDKLICGC 423
GS + +T + +LQ+ FDK + IID S + + VT+S YIP+ +L+CG
Sbjct: 366 GSEEGLAMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGR 425
Query: 424 EDGTIIITQALNAAKARLLEGGSLVKDS-PPHKVLKGHHQSVTSLLYPHGLSSKLDQSWM 482
EDG+I+I A A +LL+G +++ PPH+ L+GH VT LLYPH +S++ DQ ++
Sbjct: 426 EDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARYDQRYL 485
Query: 483 LSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVALL 542
+SG +D VI+WDIF+ E+ H F + G +T LL+ PE R + IC V DHSV LL
Sbjct: 486 ISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLL 545
Query: 543 HLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI 602
L K C++ A +HLFP+++IKW P +++L+VGC+D SVY+W+++TG L+R G A
Sbjct: 546 SLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVE 605
Query: 603 ILNCCDDSQLVKSVLPIASETLKHKSIEQRSS------------SPYQLGPLPCPGLQVE 650
ILN CD++ +P A ++L H ++ + + + ++L L L E
Sbjct: 606 ILNACDEA------VPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASE 659
Query: 651 SSCKVTDAKFCPRPFNVLPVKTKWSNVGFHILLFDLENLVELLLPTPLSDVDSSSSFYGG 710
+S K K+ V +KT ++ H+L FD+E L+ LL S +++
Sbjct: 660 ASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEAS--RPNTALISP 717
Query: 711 EVLRRAKSTVEKKTLTLRKSKTACGPLSAEALAKPITESLAQG--DNTIKFSEENDGIKR 768
E L++A + +K L + A L + + E++ + ++ + EE++ I R
Sbjct: 718 ENLQKASGSSDKGGSFLTGKRAA-------VLFQQVKETIKENIKEHLLDDEEEDEEIMR 770
Query: 769 QKKMKIS---KKMQPKPSRKVDASLTIDTAKLFLSCLLPWGVDKDLDYLCIKHLNILKLQ 825
Q++ + + + KP ++ +LT+DTAKLF+SCL WG+++ LD +C+ L +LK
Sbjct: 771 QRREESDPEYRSSKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPH 830
Query: 826 GPISLGISLNEDNFSLMLPGWDLCNSGMIKDYSGVNLFSRKVLDLSDKYTATLPNQVGIP 885
+S G+ + SLMLPG+ N K G RK LP G+
Sbjct: 831 CTVSFGLLSRGGHMSLMLPGY---NQPACKLSHGKTEVGRK-----------LPASEGVG 876
Query: 886 RGLENNCDSLRESDTIVYLLSRLFLVNKLVNMPLELACRVGSSFR-------MESIHNKM 938
+G + + T +LLS + L N L++M A +G + S +
Sbjct: 877 KGTY----GVSRAVTTQHLLSIISLANTLMSM--TNATFIGDHMKKGPTRPPRPSTPDLS 930
Query: 939 RGAGNDILNMSSFYSCLRNGKNESHVPEADL------------SLLKLIS-CWRDQSVQV 985
+ G+ + + ++ G ++ + LL++++ W+D+ ++V
Sbjct: 931 KARGSPPTSSNIVQGQIKQGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRCLEV 990
Query: 986 TEAIQAVLLAEVQQ 999
EA QA+LLAE+++
Sbjct: 991 REAAQALLLAELRR 1004
>gi|73747877 rabconnectin-3 beta isoform 1 [Homo sapiens]
Length = 1490
Score = 602 bits (1552), Expect = e-172
Identities = 347/932 (37%), Positives = 546/932 (58%), Gaps = 59/932 (6%)
Query: 8 VALWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTC 67
+ LWG+KAP H I+A+++TDD TIVTG +GQ+CLW+LS EL+I+ + LLFGH+AS+TC
Sbjct: 10 IVLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITC 69
Query: 68 LARARDFSKQPYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEGWL 127
L++A S + YIVSA+E+GEMC+W+V++G+C+E L HT I +Y S EG L
Sbjct: 70 LSKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFSVGNQREGRL 129
Query: 128 LCCGEYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVAGELKVW 187
LC G Y ++L++DA +L V++S S PDWI+ M I+ S R QED+++ +SV G LKVW
Sbjct: 130 LCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVW 189
Query: 188 DLSSSINSIQEKQDVYEKESKFLESLNCQTIRFCTYTERLLLVVFSKCWKVYDYCDFSLL 247
++S I+ +Q+ + ++E+ESK + NCQ+I FC +T+R LLVV SK W+V+D D+SLL
Sbjct: 190 IVTSEISDMQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLL 249
Query: 248 LTEVSRNGQFFAGGEVIAAHRILIWTEDGHSYIYQLLNSGL--SKSIYPADGRVLKETIY 305
+ S NGQ + GG+ +++ +++IWTE+G SYIY+L S L S S G+ ++ I
Sbjct: 250 CSGPSENGQTWTGGDFVSSDKVIIWTENGQSYIYKLPASCLPASDSFRSDVGKAVENLIP 309
Query: 306 P--HLLCSTSVQENKEQSRPFVMGYMNERKEPFYKVLFSGEVSGRITLWHIPDVPVSKFD 363
P H+L ++ + P V + +E F+K+L G+ SGR+ +W+I D +
Sbjct: 310 PVQHILLDR--KDKELLICPPVTRFFYGCREYFHKLLIQGDSSGRLNIWNISD--TADKQ 365
Query: 364 GSPREIPVTATWTLQDNFDKHDTMSQSIIDYFSGLKDGAGTAVVTSSEYIPSLDKLICGC 423
GS + +T + +LQ+ FDK + IID S + + VT+S YIP+ +L+CG
Sbjct: 366 GSEEGLAMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGR 425
Query: 424 EDGTIIITQALNAAKARLLEGGSLVKDS-PPHKVLKGHHQSVTSLLYPHGLSSKLDQSWM 482
EDG+I+I A A +LL+G +++ PPH+ L+GH VT LLYPH +S++ DQ ++
Sbjct: 426 EDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARYDQRYL 485
Query: 483 LSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVALL 542
+SG +D VI+WDIF+ E+ H F + G +T LL+ PE R + IC V DHSV LL
Sbjct: 486 ISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLL 545
Query: 543 HLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI 602
L K C++ A +HLFP+++IKW P +++L+VGC+D SVY+W+++TG L+R G A
Sbjct: 546 SLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVE 605
Query: 603 ILNCCDDSQLVKSVLPIASETLKHKSIEQRSS------------SPYQLGPLPCPGLQVE 650
ILN CD++ +P A ++L H ++ + + + ++L L L E
Sbjct: 606 ILNACDEA------VPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASE 659
Query: 651 SSCKVTDAKFCPRPFNVLPVKTKWSNVGFHILLFDLENLVELLLPTPLSDVDSSSSFYGG 710
+S K K+ V +KT ++ H+L FD+E L+ LL S +++
Sbjct: 660 ASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEAS--RPNTALISP 717
Query: 711 EVLRRAKSTVEKKTLTLRKSKTACGPLSAEALAKPITESLAQG--DNTIKFSEENDGIKR 768
E L++A + +K L + A L + + E++ + ++ + EE++ I R
Sbjct: 718 ENLQKASGSSDKGGSFLTGKRAA-------VLFQQVKETIKENIKEHLLDDEEEDEEIMR 770
Query: 769 QKKMKIS---KKMQPKPSRKVDASLTIDTAKLFLSCLLPWGVDKDLDYLCIKHLNILKLQ 825
Q++ + + + KP ++ +LT+DTAKLF+SCL WG+++ LD +C+ L +LK
Sbjct: 771 QRREESDPEYRSSKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPH 830
Query: 826 GPISLGISLNEDNFSLMLPGWDLCNSGMIKDYSGVNLFSRKVLDLSDKYTATLPNQVGIP 885
+S G+ + SLMLPG+ N K G RK LP G+
Sbjct: 831 CTVSFGLLSRGGHMSLMLPGY---NQPACKLSHGKTEVGRK-----------LPASEGVG 876
Query: 886 RGLENNCDSLRESDTIVYLLSRLFLVNKLVNM 917
+G + + T +LLS + L N L++M
Sbjct: 877 KGTY----GVSRAVTTQHLLSIISLANTLMSM 904
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 51.2 bits (121), Expect = 5e-06
Identities = 34/134 (25%), Positives = 62/134 (46%), Gaps = 14/134 (10%)
Query: 455 KVLKGHHQSVTSL-LYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVT 513
+ L GH ++ SL +P+G ++ SG D+ + LWDI + + ++ + V
Sbjct: 99 RTLMGHKANICSLDFHPYG-------EFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151
Query: 514 SLLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLI 573
L SP+ + + DH+V L L + H PV ++++HP E L
Sbjct: 152 CLRFSPDG------KWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLA 205
Query: 574 VGCADDSVYIWEIE 587
G +D ++ W++E
Sbjct: 206 SGSSDRTIRFWDLE 219
Score = 39.3 bits (90), Expect = 0.021
Identities = 43/197 (21%), Positives = 80/197 (40%), Gaps = 27/197 (13%)
Query: 404 TAVVTSSEYIPSLDKLICGCEDGTIIITQALNAAKARLLEGG------SLVKDSPPHKV- 456
T VVT + + L +++ + + ++ L A RLL G +L + P+ +
Sbjct: 3 TPVVTKTAW--KLQEIVAHASNVSSLV---LGKASGRLLATGGDDCRVNLWSINKPNCIM 57
Query: 457 -LKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSL 515
L GH V S+ + +++G + +WD+ +IL + SL
Sbjct: 58 SLTGHTSPVESVRL------NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSL 111
Query: 516 LMSPE-KFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIV 574
P +F G Q D ++ L + K C+ R H VR +++ P +L
Sbjct: 112 DFHPYGEFVASGSQ-------DTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLAS 164
Query: 575 GCADDSVYIWEIETGTL 591
D +V +W++ G +
Sbjct: 165 AADDHTVKLWDLTAGKM 181
Score = 36.6 bits (83), Expect = 0.13
Identities = 16/67 (23%), Positives = 31/67 (46%)
Query: 536 DHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHE 595
D V L + +C++ H PV ++ + E ++ G S+ +W++E + R
Sbjct: 42 DCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTL 101
Query: 596 TGERARI 602
G +A I
Sbjct: 102 MGHKANI 108
Score = 35.4 bits (80), Expect = 0.30
Identities = 41/187 (21%), Positives = 79/187 (42%), Gaps = 30/187 (16%)
Query: 8 VALWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKEL--LFGHSASV 65
++L G +P + ++ + + IV GSQ G + +W+L +AK L L GH A++
Sbjct: 57 MSLTGHTSP---VESVRLNTPEELIVAGSQSGSIRVWDLE-----AAKILRTLMGHKANI 108
Query: 66 TCLARARDFSKQ-PYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGE 124
L DF ++ S +++ + +W++ CV + YR + F G+
Sbjct: 109 CSL----DFHPYGEFVASGSQDTNIKLWDIRRKGCVFR----YRGHSQAVRCLRFSPDGK 160
Query: 125 GWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVAGE- 183
WL + V + D ++ F P V+ + + L+ S + +
Sbjct: 161 -WLASAADDHTVKLWDLTAGKMMSEFPGHTGP--------VNVVEFHPNEYLLASGSSDR 211
Query: 184 -LKVWDL 189
++ WDL
Sbjct: 212 TIRFWDL 218
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 48.5 bits (114), Expect = 3e-05
Identities = 59/228 (25%), Positives = 93/228 (40%), Gaps = 34/228 (14%)
Query: 455 KVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDI--FTEEILHKFFLEAGPV 512
K+L+GH V S + D S +LS D + WD+ FT +L++ A PV
Sbjct: 336 KILRGHCGPVYSTRF------LADSSGLLSCSEDMSIRYWDLGSFTNTVLYQG--HAYPV 387
Query: 513 TSLLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFL 572
L +SP D + L + L HL V +K+HP N+L
Sbjct: 388 WDLDISPYSLYFASGS------HDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYL 441
Query: 573 IVGCADDSVYIWEIETGTLERHETGERARII----------LNCCDDSQLVKSVLPIASE 622
G D +V +W + G R TG R ++ L + Q +K + +AS
Sbjct: 442 ATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLK-LWDLASG 500
Query: 623 TLKHKSIEQRSSSPYQLGPLPCPGL----QVESSCKVTDAK--FCPRP 664
TL +K + + + L P GL +++S +V D + +C P
Sbjct: 501 TL-YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAP 547
Score = 34.3 bits (77), Expect = 0.67
Identities = 25/126 (19%), Positives = 45/126 (35%), Gaps = 6/126 (4%)
Query: 478 DQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDH 537
+ +++ +G D V LW + F GPV SL SP + + D
Sbjct: 437 NSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG------KYLASAGEDQ 490
Query: 538 SVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETG 597
+ L L + R H + + + P + D+SV +W+I G
Sbjct: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADG 550
Query: 598 ERARII 603
+ ++
Sbjct: 551 SSSELV 556
>gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]
Length = 367
Score = 47.8 bits (112), Expect = 6e-05
Identities = 50/226 (22%), Positives = 95/226 (42%), Gaps = 39/226 (17%)
Query: 14 KAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARD 73
K H IT + + S++ + +W+L + ++ L GH+ VT LA + D
Sbjct: 100 KGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQ--PRQQLCGHAMVVTGLAVSPD 157
Query: 74 FSKQPYIVSAAENGEMCVWNVTNGQCVEKATLPYR-HTAICYYHCSFRMTGEGWLLCCGE 132
S+ + + + + + +W+V GQ VE+A++ T +C+ + E ++L E
Sbjct: 158 SSQ---LCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCW------VPREPYILQTSE 208
Query: 133 YQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVAG-------ELK 185
+ + + D++ L V H F + Q I C + D +S + E
Sbjct: 209 DKTLRLWDSRGLQVAHMFPAKQH---IQTYC-----EVSVDGHKCISCSNGFGGEGCEAT 260
Query: 186 VWDLSSSINSIQEKQDVYEKESKFLESLNCQTIRFCTYTERLLLVV 231
+WDL + N I E + + QT+ C + R L ++
Sbjct: 261 LWDLRQTRNRICEYKGHF------------QTVASCVFLPRALALM 294
Score = 39.3 bits (90), Expect = 0.021
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 6/91 (6%)
Query: 431 TQALNAAKARLLEGGSLVKDSPPHKVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSC 490
+Q +A++ R++ L S P + L GH VT GL+ D S + +G D+
Sbjct: 116 SQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVT------GLAVSPDSSQLCTGSRDNT 169
Query: 491 VILWDIFTEEILHKFFLEAGPVTSLLMSPEK 521
++LWD+ T + + + + VT L P +
Sbjct: 170 LLLWDVVTGQSVERASVSRNVVTHLCWVPRE 200
>gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]
Length = 366
Score = 47.8 bits (112), Expect = 6e-05
Identities = 50/226 (22%), Positives = 95/226 (42%), Gaps = 39/226 (17%)
Query: 14 KAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARD 73
K H IT + + S++ + +W+L + ++ L GH+ VT LA + D
Sbjct: 99 KGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQ--PRQQLCGHAMVVTGLAVSPD 156
Query: 74 FSKQPYIVSAAENGEMCVWNVTNGQCVEKATLPYR-HTAICYYHCSFRMTGEGWLLCCGE 132
S+ + + + + + +W+V GQ VE+A++ T +C+ + E ++L E
Sbjct: 157 SSQ---LCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCW------VPREPYILQTSE 207
Query: 133 YQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVAG-------ELK 185
+ + + D++ L V H F + Q I C + D +S + E
Sbjct: 208 DKTLRLWDSRGLQVAHMFPAKQH---IQTYC-----EVSVDGHKCISCSNGFGGEGCEAT 259
Query: 186 VWDLSSSINSIQEKQDVYEKESKFLESLNCQTIRFCTYTERLLLVV 231
+WDL + N I E + + QT+ C + R L ++
Sbjct: 260 LWDLRQTRNRICEYKGHF------------QTVASCVFLPRALALM 293
Score = 39.3 bits (90), Expect = 0.021
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 6/91 (6%)
Query: 431 TQALNAAKARLLEGGSLVKDSPPHKVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSC 490
+Q +A++ R++ L S P + L GH VT GL+ D S + +G D+
Sbjct: 115 SQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVT------GLAVSPDSSQLCTGSRDNT 168
Query: 491 VILWDIFTEEILHKFFLEAGPVTSLLMSPEK 521
++LWD+ T + + + + VT L P +
Sbjct: 169 LLLWDVVTGQSVERASVSRNVVTHLCWVPRE 199
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 47.0 bits (110), Expect = 1e-04
Identities = 49/192 (25%), Positives = 84/192 (43%), Gaps = 33/192 (17%)
Query: 431 TQALNAAKARLLEGGSL-----VKDSPPHKV---LKGHHQSVTSLLY-PHGLSSKLDQSW 481
T+ AKA+L S V ++P + + L GH ++V+S+ + P+G W
Sbjct: 3 TKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNG-------EW 55
Query: 482 MLSGDLDSCVILWDIFT---EEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHS 538
+ S D +I+W + E+ L+ LE ++ + S + +L D +
Sbjct: 56 LASSSADRLIIIWGAYDGKYEKTLYGHNLE---ISDVAWSSDSSRL------VSASDDKT 106
Query: 539 VALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETG----TLERH 594
+ L + CL + H V ++P N +I G D++V IWE++TG TL H
Sbjct: 107 LKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAH 166
Query: 595 ETGERARIILNC 606
A + NC
Sbjct: 167 SDPVSA-VHFNC 177
Score = 43.1 bits (100), Expect = 0.001
Identities = 58/308 (18%), Positives = 132/308 (42%), Gaps = 37/308 (12%)
Query: 19 SITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQP 78
+++++ + + + + S + + +W +++ K ++ L+GH+ ++ +A + D S+
Sbjct: 43 AVSSVKFSPNGEWLASSSADRLIIIWG-AYDGKY--EKTLYGHNLEISDVAWSSDSSR-- 97
Query: 79 YIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEGWLLCCGEYQD-VL 137
+VSA+++ + +W+V +G+C+ K + + C C+F L+ G + + V
Sbjct: 98 -LVSASDDKTLKLWDVRSGKCL-KTLKGHSNYVFC---CNFNPPSN--LIISGSFDETVK 150
Query: 138 IIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVA--GELKVWDLSSSINS 195
I + KT + + + P V ++ L+VS + G ++WD +S
Sbjct: 151 IWEVKTGKCLKTLSAHSDP--------VSAVHFNCSGSLIVSGSYDGLCRIWDAASG-QC 201
Query: 196 IQEKQDVYEKESKFLESLNCQTIRFCTYTERLLLVVFSKCWKVYDYCDFSLLLTEVSRNG 255
++ D F ++F + +L K++DY L T
Sbjct: 202 LKTLVDDDNPPVSF--------VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKN 253
Query: 256 Q---FFAGGEVIAAHRILIWTEDGHSYIYQLLNSGLSKSIYPADGRVLKETIYP--HLLC 310
+ FA V I+ +ED YI+ L + + + V+ +P +L+
Sbjct: 254 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIA 313
Query: 311 STSVQENK 318
S +++ +K
Sbjct: 314 SAALENDK 321
Score = 35.0 bits (79), Expect = 0.39
Identities = 42/188 (22%), Positives = 71/188 (37%), Gaps = 27/188 (14%)
Query: 448 VKDSPPHKVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFL 507
VK K L H V+++ + S ++SG D +WD + + L
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHF------NCSGSLIVSGSYDGLCRIWDAASGQCLKTLVD 207
Query: 508 EAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHL---------F 558
+ P S + KF G+ I+ D+++ L CL H F
Sbjct: 208 DDNPPVSFV----KFSPNGKYILTATL-DNTLKLWDYSRGRCLKTYTGHKNEKYCIFANF 262
Query: 559 PVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARIILNCCDDSQ-LVKSVL 617
V KW ++ G D+ VYIW ++T + + G +I C ++ L+ S
Sbjct: 263 SVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAA 316
Query: 618 PIASETLK 625
+T+K
Sbjct: 317 LENDKTIK 324
Score = 32.3 bits (72), Expect = 2.5
Identities = 32/150 (21%), Positives = 58/150 (38%), Gaps = 21/150 (14%)
Query: 455 KVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTS 514
K LKGH Y + + ++SG D V +W++ T + L + PV++
Sbjct: 119 KTLKGHSN------YVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSA 172
Query: 515 LLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLF-----PVRMIKWHPVE 569
+ F G I+ D + CL K L PV +K+ P
Sbjct: 173 V-----HFNCSGSLIVSGSY-DGLCRIWDAASGQCL----KTLVDDDNPPVSFVKFSPNG 222
Query: 570 NFLIVGCADDSVYIWEIETGTLERHETGER 599
+++ D+++ +W+ G + TG +
Sbjct: 223 KYILTATLDNTLKLWDYSRGRCLKTYTGHK 252
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 46.6 bits (109), Expect = 1e-04
Identities = 53/220 (24%), Positives = 89/220 (40%), Gaps = 27/220 (12%)
Query: 20 ITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQPY 79
+ ++ + D R IV+GS++ + LWN K + ++ HS V+C+ R S P
Sbjct: 108 VLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDE--SHSEWVSCV-RFSPNSSNPI 164
Query: 80 IVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEGWLLCCGEYQ-DVLI 138
IVS + + VWN+ N L H Y + ++ +G L G ++
Sbjct: 165 IVSCGWDKLVKVWNLAN------CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218
Query: 139 IDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVAGELKVWDLSSSINSIQE 198
D +++ D IN +C + L + +K+WDL I +
Sbjct: 219 WDLNEGKHLYTLDGG---DIINALCFSPNRY-----WLCAATGPSIKIWDLEGKIIVDEL 270
Query: 199 KQDVYEKESKFLESLNCQTIR--------FCTYTERLLLV 230
KQ+V SK E C ++ F YT+ L+ V
Sbjct: 271 KQEVISTSSK-AEPPQCTSLAWSADGQTLFAGYTDNLVRV 309
Score = 38.1 bits (87), Expect = 0.046
Identities = 35/144 (24%), Positives = 58/144 (40%), Gaps = 21/144 (14%)
Query: 457 LKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPV-TSL 515
LK +H T Y + ++ D S SG D +LWD+ E H + L+ G + +L
Sbjct: 184 LKTNHIGHTG--YLNTVTVSPDGSLCASGGKDGQAMLWDL--NEGKHLYTLDGGDIINAL 239
Query: 516 LMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRM---------IKWH 566
SP ++ L C S+ + LEGK + ++ + + W
Sbjct: 240 CFSPNRYWL-------CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 567 PVENFLIVGCADDSVYIWEIETGT 590
L G D+ V +W++ GT
Sbjct: 293 ADGQTLFAGYTDNLVRVWQVTIGT 316
Score = 33.1 bits (74), Expect = 1.5
Identities = 40/171 (23%), Positives = 71/171 (41%), Gaps = 19/171 (11%)
Query: 434 LNAAKARLLEGGSLVKDSP----PHKVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDS 489
L+A++ + + L +D P + L+GH V+ ++ +SS D + LSG D
Sbjct: 32 LSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV----ISS--DGQFALSGSWDG 85
Query: 490 CVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVALLHLEGK-S 548
+ LWD+ T +F V S+ S + + I D ++ L + G
Sbjct: 86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD------NRQIVSGSRDKTIKLWNTLGVCK 139
Query: 549 CLLHARKHLFPVRMIKWHP-VENFLIVGCA-DDSVYIWEIETGTLERHETG 597
+ H V +++ P N +IV C D V +W + L+ + G
Sbjct: 140 YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Score = 33.1 bits (74), Expect = 1.5
Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 18 HSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQ 77
H ++ ++I+ D + ++GS +G L LW+L+ + GH+ V +A + D
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTG---TTTRRFVGHTKDVLSVAFSSD---N 117
Query: 78 PYIVSAAENGEMCVWNVTNGQC 99
IVS + + + +WN T G C
Sbjct: 118 RQIVSGSRDKTIKLWN-TLGVC 138
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 46.6 bits (109), Expect = 1e-04
Identities = 40/151 (26%), Positives = 61/151 (40%), Gaps = 18/151 (11%)
Query: 455 KVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTS 514
K+L GH V +G S D++++LS D V LW + T L + PV
Sbjct: 537 KILYGHSGPV------YGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWD 590
Query: 515 LLMSPEKFKLRG---EQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENF 571
SP + +++ DH L G HL V ++HP N+
Sbjct: 591 TQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAG---------HLADVNCTRFHPNSNY 641
Query: 572 LIVGCADDSVYIWEIETGTLERHETGERARI 602
+ G AD +V +W++ G R TG + I
Sbjct: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPI 672
Score = 38.5 bits (88), Expect = 0.035
Identities = 21/62 (33%), Positives = 35/62 (56%), Gaps = 6/62 (9%)
Query: 12 GQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARA 71
G K P HS+T + + R + TG+ +G++ LW++ H L + L GH+ +V L +
Sbjct: 667 GHKGPIHSLT---FSPNGRFLATGATDGRVLLWDIGHGLMVGE---LKGHTDTVCSLRFS 720
Query: 72 RD 73
RD
Sbjct: 721 RD 722
Score = 31.6 bits (70), Expect = 4.3
Identities = 30/135 (22%), Positives = 47/135 (34%), Gaps = 14/135 (10%)
Query: 458 KGHHQSVTSLLY-PHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLL 516
KGH+ V + P+G + +SG D LW + L F V
Sbjct: 582 KGHNYPVWDTQFSPYGY-------YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTR 634
Query: 517 MSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGC 576
P + D +V L + +C+ H P+ + + P FL G
Sbjct: 635 FHPNS------NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGA 688
Query: 577 ADDSVYIWEIETGTL 591
D V +W+I G +
Sbjct: 689 TDGRVLLWDIGHGLM 703
Score = 31.2 bits (69), Expect = 5.7
Identities = 18/68 (26%), Positives = 29/68 (42%), Gaps = 6/68 (8%)
Query: 33 VTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQPYIVSAAENGEMCVW 92
V+G + LW H + + GH A V C R Y+ + + + + +W
Sbjct: 601 VSGGHDRVARLWATDHYQPL---RIFAGHLADVNC---TRFHPNSNYVATGSADRTVRLW 654
Query: 93 NVTNGQCV 100
+V NG CV
Sbjct: 655 DVLNGNCV 662
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 46.6 bits (109), Expect = 1e-04
Identities = 40/169 (23%), Positives = 69/169 (40%), Gaps = 17/169 (10%)
Query: 478 DQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDH 537
D +L+G D CV W+ + ++L + GPV SP+ G C D
Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD-----GHLFASASC-DC 85
Query: 538 SVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETG 597
+V L + CL + H V + + P L G D V +W++++G + R G
Sbjct: 86 TVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVG 145
Query: 598 ERARI-------ILNCCDDSQLVKSV----LPIASETLKHKSIEQRSSS 635
R I +NC +V L + + + H+++E S++
Sbjct: 146 HRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSAN 194
Score = 31.6 bits (70), Expect = 4.3
Identities = 32/169 (18%), Positives = 66/169 (39%), Gaps = 17/169 (10%)
Query: 32 IVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQPYIVSAAENGEMCV 91
+ TGS + + +W+L + + L GHSA+++CL +S + S + + + +
Sbjct: 162 LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC----YSASGLLASGSWDKTIHI 217
Query: 92 WNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEGWLLCCGEYQDVLIIDAKTLAVVHSFR 151
W T + L + + E WL G + V + D T + + +
Sbjct: 218 WKPTT-----SSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLK 272
Query: 152 SSQFPDWINCMCIVHSMRIQEDSLLVVSVAGELKVWDLSSSINSIQEKQ 200
+ + H+ D ++VS A + +S + S ++ Q
Sbjct: 273 --------GVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSKSPRDPQ 313
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 46.2 bits (108), Expect = 2e-04
Identities = 42/197 (21%), Positives = 84/197 (42%), Gaps = 25/197 (12%)
Query: 3 TSLQAVALWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLS-----HELKISAKEL 57
T L +GQK+ + + D + +VTGS +G + +WN + +LK A++
Sbjct: 203 TQLSRHIKFGQKS---HVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDN 259
Query: 58 LFGHSASVTCLARARDFSKQPYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHC 117
+V C+ +RD + + A++G++ VW + +GQC+ + + C
Sbjct: 260 FMMMDDAVLCMCFSRDTEM---LATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTC---L 313
Query: 118 SFRMTGEGWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLV 177
SF +L Q + I K+ + FR V+ +D +
Sbjct: 314 SF-SKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHS--------SFVNEATFTQDGHYI 364
Query: 178 VSVA--GELKVWDLSSS 192
+S + G +K+W++ ++
Sbjct: 365 ISASSDGTVKIWNMKTT 381
>gi|55769546 PAK1 interacting protein 1 [Homo sapiens]
Length = 392
Score = 45.1 bits (105), Expect = 4e-04
Identities = 21/84 (25%), Positives = 48/84 (57%), Gaps = 7/84 (8%)
Query: 18 HSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQ 77
H+ + + + R +VTGS++ + ++++ +++ A L HS ++TCL F
Sbjct: 41 HTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGA---LVHHSGTITCLK----FYGN 93
Query: 78 PYIVSAAENGEMCVWNVTNGQCVE 101
+++S AE+G +C+W+ +C++
Sbjct: 94 RHLISGAEDGLICIWDAKKWECLK 117
Score = 30.4 bits (67), Expect = 9.6
Identities = 42/198 (21%), Positives = 81/198 (40%), Gaps = 40/198 (20%)
Query: 404 TAVVTSSEYIPSLDKLICGCEDGTIIITQALNAAKARLLEGGSLVKDSPPHKVLKGHHQS 463
+AV +S ++ + G +D TI I + +E G+LV HH
Sbjct: 46 SAVAVNSRFV------VTGSKDETIHIYDM-----KKKIEHGALV-----------HHSG 83
Query: 464 VTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFK 523
+ L +G ++SG D + +WD E L G VT L + P
Sbjct: 84 TITCLKFYG------NRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHP---- 133
Query: 524 LRGEQIICCVCGDHSVALLHL-EGKSCLLHARKHLFPVRMIKWHP-VENFLIVGCADDSV 581
++ V D ++ +L EG+S + K +++W P E ++++ + +
Sbjct: 134 --SGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQ--NAHIVEWSPRGEQYVVI--IQNKI 187
Query: 582 YIWEIETGTLERHETGER 599
I++++T ++ T E+
Sbjct: 188 DIYQLDTASISGTITNEK 205
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 45.1 bits (105), Expect = 4e-04
Identities = 38/188 (20%), Positives = 81/188 (43%), Gaps = 14/188 (7%)
Query: 14 KAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARD 73
K H + +I + D R + +G + GQ+ LW+ S ++ L GHS +T L+
Sbjct: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVG--RTLAGHSKWITGLSWEPL 210
Query: 74 FSKQP--YIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEGWLLCCG 131
+ Y+ S++++G + +W+ T G+C E+ + + C R G+G L
Sbjct: 211 HANPECRYVASSSKDGSVRIWDTTAGRC-ERILTGHTQSVTC-----LRWGGDGLLYSAS 264
Query: 132 EYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVAGELKVWDLSS 191
+ + + + A + + + W+N M + ++ + + DL
Sbjct: 265 QDRTIKVWRAHDGVLCRTLQG--HGHWVNTMALSTDYALRTGAF--EPAEASVNPQDLQG 320
Query: 192 SINSIQEK 199
S+ ++E+
Sbjct: 321 SLQELKER 328
Score = 32.3 bits (72), Expect = 2.5
Identities = 38/148 (25%), Positives = 57/148 (38%), Gaps = 20/148 (13%)
Query: 457 LKGHHQSVTSLLY-PHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSL 515
L+GH ++V S+ + P G ++ SG D+ V WD+ TE V S+
Sbjct: 110 LEGHSEAVISVAFSPTG-------KYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSI 162
Query: 516 LMSPEKFKLRGEQIICCVCGDHSVALLHLE-GKSCLLHARKHLFPVRMIKWHPVE----- 569
SP+ KL C + + L GK H + + W P+
Sbjct: 163 SWSPDGRKLASG------CKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
Query: 570 NFLIVGCADDSVYIWEIETGTLERHETG 597
++ D SV IW+ G ER TG
Sbjct: 217 RYVASSSKDGSVRIWDTTAGRCERILTG 244
Score = 32.3 bits (72), Expect = 2.5
Identities = 24/111 (21%), Positives = 45/111 (40%), Gaps = 7/111 (6%)
Query: 482 MLSGDLDSCVILWDIFTEEI-LHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVA 540
++SG D + LW ++ L + + +L SP+ +I+ D S+
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDS------RIVASASFDKSIK 397
Query: 541 LLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTL 591
L L R H+ V I W L+ G +D ++ +W+++ L
Sbjct: 398 LWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL 448
>gi|221139921 EF-hand calcium binding domain 8 [Homo sapiens]
Length = 1288
Score = 44.3 bits (103), Expect = 6e-04
Identities = 40/147 (27%), Positives = 66/147 (44%), Gaps = 24/147 (16%)
Query: 453 PHKVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKF---FLEA 509
P ++KGH SVT H L + S ++S D + +WD+ L F F
Sbjct: 405 PVWLMKGHQTSVT-----HILVDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFAL 459
Query: 510 G--PVTSLLMSPEKFKLRGEQIICCVCGDHSVALL--HLEGKSCLLHARK---HLFPVRM 562
G P+TS + L +C +S+ +L +LE + L+ ARK H P+
Sbjct: 460 GNCPITSAYFFEKDNTL--------ICSTYSIGILKGYLEAQG-LIKARKRTTHCSPLCA 510
Query: 563 IKWHPVENFLIVGCADDSVYIWEIETG 589
+ + + ++ GC +V +WE+ TG
Sbjct: 511 VLYSKIFKQVVSGCLRGTVSVWEVVTG 537
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 44.3 bits (103), Expect = 6e-04
Identities = 42/175 (24%), Positives = 69/175 (39%), Gaps = 21/175 (12%)
Query: 434 LNAAKARLLEGGSLVKDS--------PPHK-VLKGHHQSVTSLLYPHGLSSKLDQSWMLS 484
LN AK GG L + PP K L GH VT +++ H + S M+S
Sbjct: 72 LNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIF-HPVFSV-----MVS 125
Query: 485 GDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVALLHL 544
D+ + +WD T + V + F G+ + C D ++ L
Sbjct: 126 ASEDATIKVWDYETGDFERTLKGHTDSVQDI-----SFDHSGKLLASC-SADMTIKLWDF 179
Query: 545 EGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGER 599
+G C+ H V + P + ++ D ++ +WE++TG + TG R
Sbjct: 180 QGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHR 234
Score = 40.0 bits (92), Expect = 0.012
Identities = 42/190 (22%), Positives = 73/190 (38%), Gaps = 45/190 (23%)
Query: 455 KVLKGHHQSVTSL-LYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVT 513
+ + GH +V+S+ + P+G ++S D + +W++ T + F V
Sbjct: 186 RTMHGHDHNVSSVAIMPNG-------DHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVR 238
Query: 514 SLLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVEN--- 570
+ + + G I C D +V + + K C R+H V I W P +
Sbjct: 239 MVRPNQD-----GTLIASC-SNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSS 292
Query: 571 -----------------FLIVGCADDSVYIWEIETG----TLERHETGER-------ARI 602
FL+ G D ++ +W++ TG TL H+ R +
Sbjct: 293 ISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKF 352
Query: 603 ILNCCDDSQL 612
IL+C DD L
Sbjct: 353 ILSCADDKTL 362
Score = 38.9 bits (89), Expect = 0.027
Identities = 25/105 (23%), Positives = 45/105 (42%), Gaps = 6/105 (5%)
Query: 481 WMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVA 540
++LSG D + +WD+ T L V +L F G+ I+ C D ++
Sbjct: 310 FLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVL-----FHSGGKFILSCA-DDKTLR 363
Query: 541 LLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWE 585
+ + K C+ H V + +H +++ G D +V +WE
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 43.9 bits (102), Expect = 8e-04
Identities = 57/308 (18%), Positives = 131/308 (42%), Gaps = 37/308 (12%)
Query: 19 SITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQP 78
+++++ + + + + S + + +W +++ K ++ + GH ++ +A + D +
Sbjct: 47 AVSSVKFSPNGEWLASSSADKLIKIWG-AYDGKF--EKTISGHKLGISDVAWSSDSN--- 100
Query: 79 YIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEGWLLCCGEY-QDVL 137
+VSA+++ + +W+V++G+C+ K + + C C+F L+ G + + V
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCL-KTLKGHSNYVFC---CNFNPQSN--LIVSGSFDESVR 154
Query: 138 IIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVA--GELKVWDLSSSINS 195
I D KT + + + P V ++ D L+VS + G ++WD +S
Sbjct: 155 IWDVKTGKCLKTLPAHSDP--------VSAVHFNRDGSLIVSSSYDGLCRIWDTASG-QC 205
Query: 196 IQEKQDVYEKESKFLESLNCQTIRFCTYTERLLLVVFSKCWKVYDYCDFSLLLTEVSRNG 255
++ D F ++F + +L K++DY L T
Sbjct: 206 LKTLIDDDNPPVSF--------VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257
Query: 256 Q---FFAGGEVIAAHRILIWTEDGHSYIYQLLNSGLSKSIYPADGRVLKETIYP--HLLC 310
+ FA V I+ +ED YI+ L + + + V+ +P +++
Sbjct: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIA 317
Query: 311 STSVQENK 318
S +++ +K
Sbjct: 318 SAALENDK 325
Score = 41.6 bits (96), Expect = 0.004
Identities = 34/163 (20%), Positives = 68/163 (41%), Gaps = 22/163 (13%)
Query: 436 AAKARLLEGGSLVKDSP----PHKVLK----GHHQSVTSLLY-PHGLSSKLDQSWMLSGD 486
AA+A+ S + P P+ LK GH ++V+S+ + P+G W+ S
Sbjct: 12 AARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNG-------EWLASSS 64
Query: 487 LDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVALLHLEG 546
D + +W + + ++ + S + ++ D ++ + +
Sbjct: 65 ADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS------NLLVSASDDKTLKIWDVSS 118
Query: 547 KSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETG 589
CL + H V ++P N ++ G D+SV IW+++TG
Sbjct: 119 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Score = 35.8 bits (81), Expect = 0.23
Identities = 42/188 (22%), Positives = 71/188 (37%), Gaps = 31/188 (16%)
Query: 448 VKDSPPHKVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFL 507
VK K L H V+++ + D S ++S D +WD + + L
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNR------DGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 508 EAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHL---------F 558
+ P S + KF G+ I+ D+++ L CL H F
Sbjct: 212 DDNPPVSFV----KFSPNGKYILAATL-DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 559 PVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARIILNCCDDSQLVKSVLP 618
V KW ++ G D+ VYIW ++T + + G +I C ++ +
Sbjct: 267 SVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI----- 315
Query: 619 IASETLKH 626
IAS L++
Sbjct: 316 IASAALEN 323
Score = 34.7 bits (78), Expect = 0.51
Identities = 32/150 (21%), Positives = 58/150 (38%), Gaps = 21/150 (14%)
Query: 455 KVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTS 514
K LKGH Y + + ++SG D V +WD+ T + L + PV++
Sbjct: 123 KTLKGHSN------YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA 176
Query: 515 LLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLF-----PVRMIKWHPVE 569
+ + R +I D + CL K L PV +K+ P
Sbjct: 177 VHFN------RDGSLIVSSSYDGLCRIWDTASGQCL----KTLIDDDNPPVSFVKFSPNG 226
Query: 570 NFLIVGCADDSVYIWEIETGTLERHETGER 599
+++ D+++ +W+ G + TG +
Sbjct: 227 KYILAATLDNTLKLWDYSKGKCLKTYTGHK 256
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 43.9 bits (102), Expect = 8e-04
Identities = 57/308 (18%), Positives = 131/308 (42%), Gaps = 37/308 (12%)
Query: 19 SITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQP 78
+++++ + + + + S + + +W +++ K ++ + GH ++ +A + D +
Sbjct: 47 AVSSVKFSPNGEWLASSSADKLIKIWG-AYDGKF--EKTISGHKLGISDVAWSSDSN--- 100
Query: 79 YIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEGWLLCCGEY-QDVL 137
+VSA+++ + +W+V++G+C+ K + + C C+F L+ G + + V
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCL-KTLKGHSNYVFC---CNFNPQSN--LIVSGSFDESVR 154
Query: 138 IIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVA--GELKVWDLSSSINS 195
I D KT + + + P V ++ D L+VS + G ++WD +S
Sbjct: 155 IWDVKTGKCLKTLPAHSDP--------VSAVHFNRDGSLIVSSSYDGLCRIWDTASG-QC 205
Query: 196 IQEKQDVYEKESKFLESLNCQTIRFCTYTERLLLVVFSKCWKVYDYCDFSLLLTEVSRNG 255
++ D F ++F + +L K++DY L T
Sbjct: 206 LKTLIDDDNPPVSF--------VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257
Query: 256 Q---FFAGGEVIAAHRILIWTEDGHSYIYQLLNSGLSKSIYPADGRVLKETIYP--HLLC 310
+ FA V I+ +ED YI+ L + + + V+ +P +++
Sbjct: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIA 317
Query: 311 STSVQENK 318
S +++ +K
Sbjct: 318 SAALENDK 325
Score = 41.6 bits (96), Expect = 0.004
Identities = 34/163 (20%), Positives = 68/163 (41%), Gaps = 22/163 (13%)
Query: 436 AAKARLLEGGSLVKDSP----PHKVLK----GHHQSVTSLLY-PHGLSSKLDQSWMLSGD 486
AA+A+ S + P P+ LK GH ++V+S+ + P+G W+ S
Sbjct: 12 AARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNG-------EWLASSS 64
Query: 487 LDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVALLHLEG 546
D + +W + + ++ + S + ++ D ++ + +
Sbjct: 65 ADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS------NLLVSASDDKTLKIWDVSS 118
Query: 547 KSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETG 589
CL + H V ++P N ++ G D+SV IW+++TG
Sbjct: 119 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Score = 35.8 bits (81), Expect = 0.23
Identities = 42/188 (22%), Positives = 71/188 (37%), Gaps = 31/188 (16%)
Query: 448 VKDSPPHKVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFL 507
VK K L H V+++ + D S ++S D +WD + + L
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNR------DGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 508 EAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHL---------F 558
+ P S + KF G+ I+ D+++ L CL H F
Sbjct: 212 DDNPPVSFV----KFSPNGKYILAATL-DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 559 PVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARIILNCCDDSQLVKSVLP 618
V KW ++ G D+ VYIW ++T + + G +I C ++ +
Sbjct: 267 SVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI----- 315
Query: 619 IASETLKH 626
IAS L++
Sbjct: 316 IASAALEN 323
Score = 34.7 bits (78), Expect = 0.51
Identities = 32/150 (21%), Positives = 58/150 (38%), Gaps = 21/150 (14%)
Query: 455 KVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTS 514
K LKGH Y + + ++SG D V +WD+ T + L + PV++
Sbjct: 123 KTLKGHSN------YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA 176
Query: 515 LLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLF-----PVRMIKWHPVE 569
+ + R +I D + CL K L PV +K+ P
Sbjct: 177 VHFN------RDGSLIVSSSYDGLCRIWDTASGQCL----KTLIDDDNPPVSFVKFSPNG 226
Query: 570 NFLIVGCADDSVYIWEIETGTLERHETGER 599
+++ D+++ +W+ G + TG +
Sbjct: 227 KYILAATLDNTLKLWDYSKGKCLKTYTGHK 256
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 43.9 bits (102), Expect = 8e-04
Identities = 42/186 (22%), Positives = 73/186 (39%), Gaps = 27/186 (14%)
Query: 404 TAVVTSSEYIPSLDKLICGCEDGTIIITQALNAAKARLLEGGSLVKDSPPHKVLKGHHQS 463
+A + S + S D++I G D T+++ A K +L GH
Sbjct: 219 SAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN---------------ILIGHCAE 263
Query: 464 VTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFK 523
++S S D S +L+G +D LWD + + G +L S F
Sbjct: 264 ISSA------SFNWDCSLILTGSMDKTCKLWDATNGKCVATL---TGHDDEILDSC--FD 312
Query: 524 LRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYI 583
G+ +I D + + + C+ H + I ++P N L+ G +D + I
Sbjct: 313 YTGK-LIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARI 371
Query: 584 WEIETG 589
W+ +TG
Sbjct: 372 WDAQTG 377
Score = 35.8 bits (81), Expect = 0.23
Identities = 25/133 (18%), Positives = 53/133 (39%), Gaps = 11/133 (8%)
Query: 457 LKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLL 516
L+GH V ++ + + K+ +G D LW + T + H F + L
Sbjct: 130 LEGHRNVVYAIAFNNPYGDKI-----ATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLS 184
Query: 517 MSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGC 576
+P+ ++ D + L ++ + R H + + ++ + +I G
Sbjct: 185 FNPQS------TLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGS 238
Query: 577 ADDSVYIWEIETG 589
D +V +W+ +TG
Sbjct: 239 FDHTVVVWDADTG 251
Score = 33.5 bits (75), Expect = 1.1
Identities = 20/73 (27%), Positives = 38/73 (52%), Gaps = 6/73 (8%)
Query: 32 IVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQPYIVSAAENGEMCV 91
I+TGS + + +W+ K++ +L GH A ++ + D S I++ + + +
Sbjct: 234 IITGSFDHTVVVWDADTGRKVN---ILIGHCAEISSASFNWDCS---LILTGSMDKTCKL 287
Query: 92 WNVTNGQCVEKAT 104
W+ TNG+CV T
Sbjct: 288 WDATNGKCVATLT 300
Score = 30.8 bits (68), Expect = 7.4
Identities = 33/149 (22%), Positives = 57/149 (38%), Gaps = 11/149 (7%)
Query: 455 KVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTS 514
KVLK H +T++ + S ++G D LWD + E L+ V +
Sbjct: 86 KVLKAHILPLTNV------ALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYA 139
Query: 515 LLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIV 574
+ + G++I D + L +E C R H + + ++P +
Sbjct: 140 IAFNNPY----GDKI-ATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVAT 194
Query: 575 GCADDSVYIWEIETGTLERHETGERARII 603
G D + +W+I+ G G A II
Sbjct: 195 GSMDTTAKLWDIQNGEEVYTLRGHSAEII 223
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 42.4 bits (98), Expect = 0.002
Identities = 42/171 (24%), Positives = 75/171 (43%), Gaps = 36/171 (21%)
Query: 32 IVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQPYIVSAAENGEMCV 91
+VT S++ + +W+++ I+ + +L GH A+V + DF + YIVSA+ + + V
Sbjct: 360 MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV----DFDDK-YIVSASGDRTIKV 414
Query: 92 WNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEG------WLLCCGEYQDVLIIDAKTLA 145
WN + + V R A Y ++G W + CG VL
Sbjct: 415 WNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVL-------- 466
Query: 146 VVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVA--GELKVWDLSSSIN 194
+ + C I+ D+ +VS A G++KVWDL ++++
Sbjct: 467 -------EGHEELVRC--------IRFDNKRIVSGAYDGKIKVWDLVAALD 502
Score = 37.7 bits (86), Expect = 0.060
Identities = 39/172 (22%), Positives = 77/172 (44%), Gaps = 35/172 (20%)
Query: 27 DDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQPYIVSAAEN 86
DDQ+ IV+G ++ + +W+ + + K +L GH+ SV CL + I++ + +
Sbjct: 276 DDQK-IVSGLRDNTIKIWDKN---TLECKRILTGHTGSVLCLQ-----YDERVIITGSSD 326
Query: 87 GEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEGWLLCCGEYQDVLIIDAKTLAV 146
+ VW+V G+ + TL + A+ H F G ++ C + + + + D +
Sbjct: 327 STVRVWDVNTGEMLN--TLIHHCEAV--LHLRF---NNGMMVTCSKDRSIAVWDMAS--- 376
Query: 147 VHSFRSSQFPDWINCMCIVHSMR-----IQEDSLLVVSVAGE--LKVWDLSS 191
P I ++ R + D +VS +G+ +KVW+ S+
Sbjct: 377 ---------PTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTST 419
Score = 34.7 bits (78), Expect = 0.51
Identities = 37/180 (20%), Positives = 68/180 (37%), Gaps = 49/180 (27%)
Query: 455 KVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTS 514
++L GH SV L Y D+ +++G DS V +WD+ T E+L+ V
Sbjct: 301 RILTGHTGSVLCLQY--------DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 352
Query: 515 L--------------------LMSPEKFKLR---------------GEQIICCVCGDHSV 539
L + SP LR ++ I GD ++
Sbjct: 353 LRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTI 412
Query: 540 ALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETG----TLERHE 595
+ + + H + +++ + ++ G +D+++ +W+IE G LE HE
Sbjct: 413 KVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 470
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 42.4 bits (98), Expect = 0.002
Identities = 42/171 (24%), Positives = 75/171 (43%), Gaps = 36/171 (21%)
Query: 32 IVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQPYIVSAAENGEMCV 91
+VT S++ + +W+++ I+ + +L GH A+V + DF + YIVSA+ + + V
Sbjct: 396 MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV----DFDDK-YIVSASGDRTIKV 450
Query: 92 WNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEG------WLLCCGEYQDVLIIDAKTLA 145
WN + + V R A Y ++G W + CG VL
Sbjct: 451 WNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVL-------- 502
Query: 146 VVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVA--GELKVWDLSSSIN 194
+ + C I+ D+ +VS A G++KVWDL ++++
Sbjct: 503 -------EGHEELVRC--------IRFDNKRIVSGAYDGKIKVWDLVAALD 538
Score = 37.7 bits (86), Expect = 0.060
Identities = 39/172 (22%), Positives = 77/172 (44%), Gaps = 35/172 (20%)
Query: 27 DDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQPYIVSAAEN 86
DDQ+ IV+G ++ + +W+ + + K +L GH+ SV CL + I++ + +
Sbjct: 312 DDQK-IVSGLRDNTIKIWDKN---TLECKRILTGHTGSVLCLQ-----YDERVIITGSSD 362
Query: 87 GEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEGWLLCCGEYQDVLIIDAKTLAV 146
+ VW+V G+ + TL + A+ H F G ++ C + + + + D +
Sbjct: 363 STVRVWDVNTGEMLN--TLIHHCEAV--LHLRF---NNGMMVTCSKDRSIAVWDMAS--- 412
Query: 147 VHSFRSSQFPDWINCMCIVHSMR-----IQEDSLLVVSVAGE--LKVWDLSS 191
P I ++ R + D +VS +G+ +KVW+ S+
Sbjct: 413 ---------PTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTST 455
Score = 34.7 bits (78), Expect = 0.51
Identities = 37/180 (20%), Positives = 68/180 (37%), Gaps = 49/180 (27%)
Query: 455 KVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTS 514
++L GH SV L Y D+ +++G DS V +WD+ T E+L+ V
Sbjct: 337 RILTGHTGSVLCLQY--------DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 388
Query: 515 L--------------------LMSPEKFKLR---------------GEQIICCVCGDHSV 539
L + SP LR ++ I GD ++
Sbjct: 389 LRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTI 448
Query: 540 ALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETG----TLERHE 595
+ + + H + +++ + ++ G +D+++ +W+IE G LE HE
Sbjct: 449 KVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 506
>gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 3526
Score = 42.4 bits (98), Expect = 0.002
Identities = 42/192 (21%), Positives = 80/192 (41%), Gaps = 25/192 (13%)
Query: 3 TSLQAVALWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELK----ISAKELL 58
T + ++ WGQ I + + ++TG +C+W + + ++ K+ L
Sbjct: 3071 TVYECLSEWGQ-------ILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTLKQAL 3123
Query: 59 FGHSASVTCLARARDFSKQPYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCS 118
GH+ +VTC + + IVS + + +W++ + T H A C
Sbjct: 3124 LGHTDTVTCATASLAYH---IIVSGSRDRTCIIWDLNK---LSFLTQLRGHRAPVSALCI 3177
Query: 119 FRMTGEGWLLCCGEYQDVLIIDAKTLAVVHSF--RSSQFPDWINCMCIVHSMRIQEDSLL 176
+TG+ + C G Y V I+ + V++F RS Q I C C+ +++
Sbjct: 3178 NELTGD-IVSCAGTYIHVWSINGNPIVSVNTFTGRSQQ----IICCCMSEMNEWDTQNVI 3232
Query: 177 VVSVA-GELKVW 187
V + G ++ W
Sbjct: 3233 VTGHSDGVVRFW 3244
>gi|124028510 WD40-repeat protein upregulated in HCC isoform c [Homo
sapiens]
Length = 552
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/106 (22%), Positives = 53/106 (50%), Gaps = 4/106 (3%)
Query: 20 ITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQPY 79
+TAI T D + +++G EG++ +W + + + +E L H +SV+C+ R+ +
Sbjct: 352 VTAIATTSDCKRVISGGGEGEVRVWQIGCQTQ-KLEEALKEHKSSVSCIRVKRNNEE--- 407
Query: 80 IVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEG 125
V+A+ +G +W++ + + +CY+ F++ G
Sbjct: 408 CVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSG 453
>gi|124028512 WD40-repeat protein upregulated in HCC isoform b [Homo
sapiens]
Length = 620
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/106 (22%), Positives = 53/106 (50%), Gaps = 4/106 (3%)
Query: 20 ITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQPY 79
+TAI T D + +++G EG++ +W + + + +E L H +SV+C+ R+ +
Sbjct: 420 VTAIATTSDCKRVISGGGEGEVRVWQIGCQTQ-KLEEALKEHKSSVSCIRVKRNNEE--- 475
Query: 80 IVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEG 125
V+A+ +G +W++ + + +CY+ F++ G
Sbjct: 476 CVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSG 521
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/113 (23%), Positives = 51/113 (45%), Gaps = 6/113 (5%)
Query: 478 DQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDH 537
D ++ SG +D + ++DI T ++LH A P+ SL SP+ Q++ D
Sbjct: 159 DGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPD------SQLLVTASDDG 212
Query: 538 SVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGT 590
+ + ++ + H V + + P + + +D SV +W++ T T
Sbjct: 213 YIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRT 265
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 41.6 bits (96), Expect = 0.004
Identities = 42/185 (22%), Positives = 79/185 (42%), Gaps = 36/185 (19%)
Query: 18 HSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQ 77
H+ + + +VT S++ + +W+++ I+ + +L GH A+V + DF +
Sbjct: 319 HNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV----DFDDK 374
Query: 78 PYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEG------WLLCCG 131
YIVSA+ + + VW+ + + V R A Y ++G W + CG
Sbjct: 375 -YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG 433
Query: 132 EYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVA--GELKVWDL 189
VL + + C I+ D+ +VS A G++KVWDL
Sbjct: 434 ACLRVL---------------EGHEELVRC--------IRFDNKRIVSGAYDGKIKVWDL 470
Query: 190 SSSIN 194
++++
Sbjct: 471 QAALD 475
Score = 37.4 bits (85), Expect = 0.079
Identities = 40/170 (23%), Positives = 71/170 (41%), Gaps = 30/170 (17%)
Query: 455 KVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTS 514
KVL GH SV L Y D+ +++G DS V +WD+ T E+L+ V
Sbjct: 274 KVLTGHTGSVLCLQY--------DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLH 325
Query: 515 LLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHAR---KHLFPVRMIKWHPVENF 571
L S G + C D S+A+ + + + R H V ++ + + +
Sbjct: 326 LRFS------NGLMVTC--SKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD--DKY 375
Query: 572 LIVGCADDSVYIWEIET----GTLERHETG-----ERARIILNCCDDSQL 612
++ D ++ +W T TL H+ G R R++++ D+ +
Sbjct: 376 IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTI 425
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 41.6 bits (96), Expect = 0.004
Identities = 42/185 (22%), Positives = 79/185 (42%), Gaps = 36/185 (19%)
Query: 18 HSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQ 77
H+ + + +VT S++ + +W+++ I+ + +L GH A+V + DF +
Sbjct: 285 HNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV----DFDDK 340
Query: 78 PYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEG------WLLCCG 131
YIVSA+ + + VW+ + + V R A Y ++G W + CG
Sbjct: 341 -YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG 399
Query: 132 EYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVA--GELKVWDL 189
VL + + C I+ D+ +VS A G++KVWDL
Sbjct: 400 ACLRVL---------------EGHEELVRC--------IRFDNKRIVSGAYDGKIKVWDL 436
Query: 190 SSSIN 194
++++
Sbjct: 437 QAALD 441
Score = 37.4 bits (85), Expect = 0.079
Identities = 40/170 (23%), Positives = 71/170 (41%), Gaps = 30/170 (17%)
Query: 455 KVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTS 514
KVL GH SV L Y D+ +++G DS V +WD+ T E+L+ V
Sbjct: 240 KVLTGHTGSVLCLQY--------DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLH 291
Query: 515 LLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHAR---KHLFPVRMIKWHPVENF 571
L S G + C D S+A+ + + + R H V ++ + + +
Sbjct: 292 LRFS------NGLMVTC--SKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD--DKY 341
Query: 572 LIVGCADDSVYIWEIET----GTLERHETG-----ERARIILNCCDDSQL 612
++ D ++ +W T TL H+ G R R++++ D+ +
Sbjct: 342 IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTI 391
>gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens]
Length = 400
Score = 41.6 bits (96), Expect = 0.004
Identities = 40/138 (28%), Positives = 57/138 (41%), Gaps = 19/138 (13%)
Query: 453 PHKVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPV 512
P K + H VT +L+ L+ W+LS D F G
Sbjct: 106 PVKNYQAHQSRVTMILFV------LELEWVLSTGQDKQ------FAWHCSESGQRLGGYR 153
Query: 513 TSLLMSPEKFKLRGEQIICCVCGDHS--VALLHLEGKSCLLHA--RKHLFPVRMIKWHPV 568
TS + S +F + + GDHS V +L LE ++C L R H V + W PV
Sbjct: 154 TSAVASGLQFDVETRHVFI---GDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPV 210
Query: 569 ENFLIVGCADDSVYIWEI 586
+ L G +D SV +W+I
Sbjct: 211 QRVLFSGSSDHSVIMWDI 228
Score = 30.4 bits (67), Expect = 9.6
Identities = 21/75 (28%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 20 ITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQPY 79
+TA+ QR + +GS + + +W++ K +A EL GH+ V L+ A+ +
Sbjct: 202 VTALCWDPVQRVLFSGSSDHSVIMWDIGGR-KGTAIELQ-GHNDRVQALSYAQHTRQ--- 256
Query: 80 IVSAAENGEMCVWNV 94
++S +G + VWN+
Sbjct: 257 LISCGGDGGIVVWNM 271
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 41.6 bits (96), Expect = 0.004
Identities = 42/185 (22%), Positives = 79/185 (42%), Gaps = 36/185 (19%)
Query: 18 HSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQ 77
H+ + + +VT S++ + +W+++ I+ + +L GH A+V + DF +
Sbjct: 306 HNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV----DFDDK 361
Query: 78 PYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEG------WLLCCG 131
YIVSA+ + + VW+ + + V R A Y ++G W + CG
Sbjct: 362 -YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG 420
Query: 132 EYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVA--GELKVWDL 189
VL + + C I+ D+ +VS A G++KVWDL
Sbjct: 421 ACLRVL---------------EGHEELVRC--------IRFDNKRIVSGAYDGKIKVWDL 457
Query: 190 SSSIN 194
++++
Sbjct: 458 QAALD 462
Score = 37.4 bits (85), Expect = 0.079
Identities = 40/170 (23%), Positives = 71/170 (41%), Gaps = 30/170 (17%)
Query: 455 KVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTS 514
KVL GH SV L Y D+ +++G DS V +WD+ T E+L+ V
Sbjct: 261 KVLTGHTGSVLCLQY--------DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLH 312
Query: 515 LLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHAR---KHLFPVRMIKWHPVENF 571
L S G + C D S+A+ + + + R H V ++ + + +
Sbjct: 313 LRFS------NGLMVTC--SKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD--DKY 362
Query: 572 LIVGCADDSVYIWEIET----GTLERHETG-----ERARIILNCCDDSQL 612
++ D ++ +W T TL H+ G R R++++ D+ +
Sbjct: 363 IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTI 412
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 41.6 bits (96), Expect = 0.004
Identities = 41/179 (22%), Positives = 71/179 (39%), Gaps = 25/179 (13%)
Query: 446 SLVKDSPPHKVLKGHHQSVTSL-LYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHK 504
S +D + KGH ++TSL L P+G SW D+ ++LW+ ++
Sbjct: 3 SATEDPVLERYFKGHKAAITSLDLSPNG-KQLATASW------DTFLMLWNFKPHARAYR 55
Query: 505 FFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIK 564
+ VTS+ SP ++ D +V L + + + H PVR +
Sbjct: 56 YVGHKDVVTSVQFSPHG------NLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVD 109
Query: 565 WHPVENFLIVGCADDSVYIWEIETG----TLERHETGER-------ARIILNCCDDSQL 612
+ FL D S+ +W + +L RH R R+I++C +D +
Sbjct: 110 FSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTI 168
Score = 34.7 bits (78), Expect = 0.51
Identities = 37/176 (21%), Positives = 75/176 (42%), Gaps = 17/176 (9%)
Query: 14 KAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARD 73
KA + ++ + D + + T S++ + +W++ + + + L+ H+ V C + D
Sbjct: 99 KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYS---LYRHTHWVRCAKFSPD 155
Query: 74 FSKQPYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEGWLLCCGEY 133
IVS +E+ + +W+ TN QCV + + F +G + G
Sbjct: 156 GR---LIVSCSEDKTIKIWDTTNKQCVNN----FSDSVGFANFVDFNPSGT-CIASAGSD 207
Query: 134 QDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVAGELKVWDL 189
Q V + D + ++ ++ +NC+ S + L+ S G LK+ DL
Sbjct: 208 QTVKVWDVRVNKLLQHYQVHS--GGVNCI----SFHPSGNYLITASSDGTLKILDL 257
Score = 33.5 bits (75), Expect = 1.1
Identities = 25/114 (21%), Positives = 46/114 (40%), Gaps = 6/114 (5%)
Query: 478 DQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDH 537
D ++S D + +WD ++ ++ F G + +P I D
Sbjct: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSG------TCIASAGSDQ 208
Query: 538 SVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTL 591
+V + + L H + H V I +HP N+LI +D ++ I ++ G L
Sbjct: 209 TVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRL 262
Score = 32.7 bits (73), Expect = 1.9
Identities = 19/117 (16%), Positives = 47/117 (40%), Gaps = 6/117 (5%)
Query: 478 DQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDH 537
D ++ + D + +W ++ + L+ + V SP+ G I+ C D
Sbjct: 113 DGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPD-----GRLIVSC-SEDK 166
Query: 538 SVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERH 594
++ + K C+ + + + ++P + +D +V +W++ L +H
Sbjct: 167 TIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQH 223
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,989,441
Number of Sequences: 37866
Number of extensions: 1953587
Number of successful extensions: 5915
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 118
Number of HSP's that attempted gapping in prelim test: 5205
Number of HSP's gapped (non-prelim): 684
length of query: 1102
length of database: 18,247,518
effective HSP length: 113
effective length of query: 989
effective length of database: 13,968,660
effective search space: 13815004740
effective search space used: 13815004740
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.