Guide to the Human Genome
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Search of human proteins with 157502179

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157502179 tetratricopeptide repeat domain 21A isoform 1
[Homo sapiens]
         (1321 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo...  2624   0.0  
gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo...  2617   0.0  
gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens]      1373   0.0  
gi|7661950 SH2 domain binding protein 1 [Homo sapiens]                 51   6e-06
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]                     50   1e-05
gi|83415184 transmembrane and tetratricopeptide repeat containin...    50   1e-05
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]       45   6e-04
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]       45   6e-04
gi|34304360 nephrocystin 3 [Homo sapiens]                              44   8e-04
gi|22749211 transmembrane and tetratricopeptide repeat containin...    44   0.001
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi...    42   0.004
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi...    42   0.004
gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sap...    40   0.019
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi...    39   0.025
gi|118402596 cell division cycle protein 23 [Homo sapiens]             39   0.043
gi|224809432 transmembrane and tetratricopeptide repeat containi...    38   0.056
gi|110225358 tetratricopeptide repeat domain 7A [Homo sapiens]         37   0.096
gi|95147555 microtubule-associated protein 1A [Homo sapiens]           37   0.16 
gi|17149828 NMDA receptor regulated 1 [Homo sapiens]                   37   0.16 
gi|225735593 RNA polymerase II associated protein 3 isoform 2 [H...    36   0.21 
gi|225735591 RNA polymerase II associated protein 3 isoform 1 [H...    36   0.21 
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ...    36   0.21 
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ...    36   0.21 
gi|15619013 43 kD receptor-associated protein of the synapse iso...    35   0.48 
gi|209976994 adenylate cyclase 10 [Homo sapiens]                       35   0.62 
gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens]          35   0.62 
gi|4503729 FK506 binding protein 52 [Homo sapiens]                     34   1.1  
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...    33   1.4  
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...    33   1.4  
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom...    33   1.4  

>gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo
            sapiens]
          Length = 1321

 Score = 2624 bits (6802), Expect = 0.0
 Identities = 1321/1321 (100%), Positives = 1321/1321 (100%)

Query: 1    MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAIS 60
            MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAIS
Sbjct: 1    MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAIS 60

Query: 61   DLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFL 120
            DLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFL
Sbjct: 61   DLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFL 120

Query: 121  WLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDV 180
            WLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDV
Sbjct: 121  WLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDV 180

Query: 181  LGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRI 240
            LGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRI
Sbjct: 181  LGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRI 240

Query: 241  LEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLK 300
            LEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLK
Sbjct: 241  LEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLK 300

Query: 301  KIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEA 360
            KIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEA
Sbjct: 301  KIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEA 360

Query: 361  MKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHK 420
            MKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHK
Sbjct: 361  MKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHK 420

Query: 421  GEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIV 480
            GEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIV
Sbjct: 421  GEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIV 480

Query: 481  SPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHL 540
            SPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHL
Sbjct: 481  SPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHL 540

Query: 541  LMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVI 600
            LMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVI
Sbjct: 541  LMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVI 600

Query: 601  KLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEE 660
            KLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEE
Sbjct: 601  KLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEE 660

Query: 661  NRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYR 720
            NRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYR
Sbjct: 661  NRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYR 720

Query: 721  ELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYT 780
            ELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYT
Sbjct: 721  ELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYT 780

Query: 781  EAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKC 840
            EAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKC
Sbjct: 781  EAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKC 840

Query: 841  LLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHY 900
            LLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHY
Sbjct: 841  LLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHY 900

Query: 901  LAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETA 960
            LAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETA
Sbjct: 901  LAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETA 960

Query: 961  SVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKK 1020
            SVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKK
Sbjct: 961  SVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKK 1020

Query: 1021 VSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEV 1080
            VSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEV
Sbjct: 1021 VSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEV 1080

Query: 1081 VGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATRE 1140
            VGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATRE
Sbjct: 1081 VGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATRE 1140

Query: 1141 KANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAED 1200
            KANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAED
Sbjct: 1141 KANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAED 1200

Query: 1201 LEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYK 1260
            LEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYK
Sbjct: 1201 LEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYK 1260

Query: 1261 LAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDYPKIREEILEKARRSLR 1320
            LAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDYPKIREEILEKARRSLR
Sbjct: 1261 LAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDYPKIREEILEKARRSLR 1320

Query: 1321 P 1321
            P
Sbjct: 1321 P 1321


>gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo
            sapiens]
          Length = 1320

 Score = 2617 bits (6784), Expect = 0.0
 Identities = 1320/1321 (99%), Positives = 1320/1321 (99%), Gaps = 1/1321 (0%)

Query: 1    MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAIS 60
            MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAIS
Sbjct: 1    MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAIS 60

Query: 61   DLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFL 120
            DLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFL
Sbjct: 61   DLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFL 120

Query: 121  WLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDV 180
            WLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDV
Sbjct: 121  WLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDV 180

Query: 181  LGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRI 240
            LGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRI
Sbjct: 181  LGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRI 240

Query: 241  LEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLK 300
            LEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLK
Sbjct: 241  LEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLK 300

Query: 301  KIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEA 360
            KIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEA
Sbjct: 301  KIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEA 360

Query: 361  MKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHK 420
            MKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHK
Sbjct: 361  MKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHK 420

Query: 421  GEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIV 480
            GEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIV
Sbjct: 421  GEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIV 480

Query: 481  SPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHL 540
            SPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYS ELENAQSILQRCLELDPASVDAHL
Sbjct: 481  SPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYS-ELENAQSILQRCLELDPASVDAHL 539

Query: 541  LMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVI 600
            LMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVI
Sbjct: 540  LMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVI 599

Query: 601  KLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEE 660
            KLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEE
Sbjct: 600  KLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEE 659

Query: 661  NRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYR 720
            NRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYR
Sbjct: 660  NRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYR 719

Query: 721  ELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYT 780
            ELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYT
Sbjct: 720  ELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYT 779

Query: 781  EAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKC 840
            EAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKC
Sbjct: 780  EAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKC 839

Query: 841  LLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHY 900
            LLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHY
Sbjct: 840  LLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHY 899

Query: 901  LAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETA 960
            LAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETA
Sbjct: 900  LAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETA 959

Query: 961  SVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKK 1020
            SVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKK
Sbjct: 960  SVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKK 1019

Query: 1021 VSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEV 1080
            VSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEV
Sbjct: 1020 VSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEV 1079

Query: 1081 VGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATRE 1140
            VGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATRE
Sbjct: 1080 VGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATRE 1139

Query: 1141 KANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAED 1200
            KANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAED
Sbjct: 1140 KANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAED 1199

Query: 1201 LEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYK 1260
            LEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYK
Sbjct: 1200 LEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYK 1259

Query: 1261 LAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDYPKIREEILEKARRSLR 1320
            LAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDYPKIREEILEKARRSLR
Sbjct: 1260 LAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDYPKIREEILEKARRSLR 1319

Query: 1321 P 1321
            P
Sbjct: 1320 P 1320


>gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens]
          Length = 1316

 Score = 1373 bits (3555), Expect = 0.0
 Identities = 677/1315 (51%), Positives = 942/1315 (71%), Gaps = 13/1315 (0%)

Query: 12   IIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDV 71
            I YY QE+YFHHV   A+ G++++ +DPV +F+ AYG L E   Q+A+ + E+I++  DV
Sbjct: 10   INYYCQERYFHHVLLVASEGIKRYGSDPVFRFYHAYGTLMEGKTQEALREFEAIKNKQDV 69

Query: 72   SLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKE 131
            SLCS +ALIYAHK     DREAI E +  +KE RK     ALY+AGLFLW IGRHDKA+E
Sbjct: 70   SLCSLLALIYAHKMSPNPDREAILESDARVKEQRKGAGEKALYHAGLFLWHIGRHDKARE 129

Query: 132  YIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFM 191
            YIDRM+KIS G ++ +VL+ W+D+T  K    KKA++Y E+G+QD  D   L+GKA    
Sbjct: 130  YIDRMIKISDGSKQGHVLKAWLDITRGKEPYTKKALKYFEEGLQDGNDTFALLGKAQCLE 189

Query: 192  MQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNIDAC 251
            M+QNYS ALE VNQI V   SFLPA V KM+L LA QDW+QTVE   R+L +D  N++A 
Sbjct: 190  MRQNYSGALETVNQIIVNFPSFLPAFVKKMKLQLALQDWDQTVETAQRLLLQDSQNVEAL 249

Query: 252  QILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGS 311
            ++  ++ + REG++        +KA+  + NL   L+  EP+N  L     +  SR CG 
Sbjct: 250  RMQALYYVCREGDI--------EKASTKLENLGNTLDAMEPQNAQLFYNITLAFSRTCGR 301

Query: 312  HQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGL 371
             Q+IL  + + +ER F   P     ATELGY  IL+ +VKEAL WY  AM LD+  ++ L
Sbjct: 302  SQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSAL 361

Query: 372  TGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTALLKE 431
             G I C ++EG L++A+ +LEFL E+Q+S+GKS  LI+L A+L  +K+K +EE   LL +
Sbjct: 362  VGFIQCQLIEGQLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLND 421

Query: 432  AVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVIL 491
             ++ HFS ++G+PLG +YFEKL+P FL+ I  EYL FCP QP  PGQ + PLL++   +L
Sbjct: 422  VLDTHFSQLEGLPLGIQYFEKLNPDFLLEIVMEYLSFCPMQPASPGQPLCPLLRRCISVL 481

Query: 492  NPVVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMCQIYLAQGN 551
              VV+  P L+  ++L+A+V+Y SG++E A + LQ CLE +P+  DAHLL+ Q+YL+Q  
Sbjct: 482  ETVVRTVPGLLQTVFLIAKVKYLSGDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQEK 541

Query: 552  FGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKK---E 608
              +C   LEL +S++F+VRD+PLYHLIKA++  K G+  +AIKTL M + LP +K+    
Sbjct: 542  VKLCSQSLELCLSYDFKVRDYPLYHLIKAQSQKKMGEIADAIKTLHMAMSLPGMKRIGAS 601

Query: 609  EGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANV 668
               K  +  V  S R SI LEL++  RLNGE HEATKV+QD I+EF GT EE R+TIAN 
Sbjct: 602  TKSKDRKTEVDTSHRLSIFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIANA 661

Query: 669  DLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPG 728
            DL L++G+++ AL++L+N+  +Q  ++EAREKMA+IYL+  +D+ LYI C+RE+ E +  
Sbjct: 662  DLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMAN 721

Query: 729  PHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEA 788
            P + LLLGDA M+ILEPE+A+  Y++A  QNP D +LAS++G A +K H Y+ AI YYEA
Sbjct: 722  PRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEA 781

Query: 789  AQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVY 848
            A K   +++LC DL +LLLKLK  +KAEKVL+ AL H+ V ++ ++M D +C +LLAKVY
Sbjct: 782  ALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVY 841

Query: 849  -KSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYD 907
             K  K    I  L +A +LQ+R+LKRV +EQP+ +P+QK LAA IC + A+H +A+++Y+
Sbjct: 842  SKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQRDYE 901

Query: 908  KAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADL 967
            KA++ Y++   +  TDNK+MLELA+LYL Q   D C + CA+LLQ++Q++E A+++MADL
Sbjct: 902  KAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMADL 961

Query: 968  MFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPL 1027
            MFRKQ +E A+    Q+LE+ PDN++ L +LIDLLRR GKLED+P FF +A+K +SR  L
Sbjct: 962  MFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMAEKRNSRAKL 1021

Query: 1028 EPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFE 1087
            EPGF YC+G+Y W+ G+PN+AL+  NKARKD  WGQ+A+Y+M++ICLNPDNE VGGE FE
Sbjct: 1022 EPGFQYCKGLYLWYTGEPNDALRHFNKARKDRDWGQNALYNMIEICLNPDNETVGGEVFE 1081

Query: 1088 N-QGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATREKANMEA 1146
            N  G   N  EK+E  Q  V TAEKLL+E  P +     QLR+++  C +AT++K+N+E 
Sbjct: 1082 NLDGDLGNSTEKQESVQLAVRTAEKLLKELKPQTVQGHVQLRIMENYCLMATKQKSNVEQ 1141

Query: 1147 ALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWL 1206
            AL +F +IA +EK+ +PALL +A AY+ LKQ P+AR QLKR+AK  W   +AE+ EKSWL
Sbjct: 1142 ALNTFTEIAASEKEHIPALLGMATAYMILKQTPRARNQLKRIAKMNWNAIDAEEFEKSWL 1201

Query: 1207 LLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYS 1266
            LLADIY Q +K+D+A +LL+RC+++N+SC KAYEYMG+IMEKEQ+Y DA  NY++AWKYS
Sbjct: 1202 LLADIYIQSAKYDMAEDLLKRCLRHNRSCCKAYEYMGYIMEKEQAYTDAALNYEMAWKYS 1261

Query: 1267 HHANPAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDYPKIREEILEKARRSLRP 1321
            +  NPA+G+KLAFNYLK K++V++I+IC+ VL  HP YPKIR++IL+KAR SLRP
Sbjct: 1262 NRTNPAVGYKLAFNYLKAKRYVDSIDICHQVLEAHPTYPKIRKDILDKARASLRP 1316


>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
          Length = 1173

 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 117/600 (19%), Positives = 236/600 (39%), Gaps = 88/600 (14%)

Query: 734  LLGDALMSILEPEK--ALEVYDEAYRQNPH-DASLASRIGHAYVKAHQYTEAIEYYEAAQ 790
            LLG A +S  + +   AL  Y +A R NP   A +   +GH +VK ++  +A   +  A 
Sbjct: 166  LLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRAL 225

Query: 791  KINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALE-----HDIVQDIPSMMNDVKCLLLLA 845
            ++N +   C      L  L+  NK    +K  ++     + I    P ++N +       
Sbjct: 226  ELNSK---CVGALVGLAVLELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLANHFFFK 282

Query: 846  KVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKE 905
            K Y   +  A+    N  ++                      + A  C Q A  +  +++
Sbjct: 283  KDYSKVQHLALHAFHNTEVEA---------------------MQAESCYQLARSFHVQED 321

Query: 906  YDKAVQSYKDVFSYLPTDNKV-MLELAQLYLLQGHLDLCEQHC--AILLQTEQNHETASV 962
            YD+A Q Y     +  +   +    L Q+Y+ +G  +   Q C   +L     N+ET  +
Sbjct: 322  YDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQ-CFEKVLKAYPNNYETMKI 380

Query: 963  L--MADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFE---- 1016
            L  +      ++K + A     +V E+ PD+     +L  +L ++     + A+      
Sbjct: 381  LGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGALSAYGTATRI 440

Query: 1017 LAKKVSSRVPLEPGFNYCRGIYCWHIGQPNEALKF----LNKARKDSTWGQSAIYHMVQI 1072
            L +KV + VP E   N   G   + +G   EA K+    L++A+ ++   +   Y+ + +
Sbjct: 441  LQEKVQADVPPEILNNV--GALHFRLGNLGEAKKYFLASLDRAKAEAEHDEH-YYNAISV 497

Query: 1073 CLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQG 1132
              + +   +     E   AE  Y              + +LRE   H +     LRL   
Sbjct: 498  TTSYNLARLYEAMCEFHEAEKLY--------------KNILRE---HPNYVDCYLRL--- 537

Query: 1133 LCRLATREKANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTP 1192
                  R+K N   A   F +  Q  +D   A   +   ++  ++    + + +R+ K P
Sbjct: 538  --GAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQP 595

Query: 1193 WVLSEAEDLEKSWLLLADIYCQ------------GSKFDLALELLRRCVQYNKSCYKAYE 1240
               S+      S L L +++ Q                D AL + ++ ++ +     A  
Sbjct: 596  STQSDT----YSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAAN 651

Query: 1241 YMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDVLRE 1300
             +G ++  +  +++A   +    + +   +  +   LA  Y++ K+++ A+++  + LR+
Sbjct: 652  GIGAVLAHKGYFREARDVFAQVREATADISD-VWLNLAHIYVEQKQYISAVQMYENCLRK 710



 Score = 37.7 bits (86), Expect = 0.073
 Identities = 70/327 (21%), Positives = 130/327 (39%), Gaps = 54/327 (16%)

Query: 731  TSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQ 790
            TS  L     ++ E  +A ++Y    R++P+      R+G        + EA ++++ A 
Sbjct: 499  TSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEAL 558

Query: 791  KINGQDF--LCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVY 848
            +IN QD       +G L L  ++    +K  ++ L+       PS  +D   +L L  V+
Sbjct: 559  QIN-QDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQ------PSTQSDTYSMLALGNVW 611

Query: 849  ------KSHKKEAVIETLNKALDLQSRIL-------------------KRVPLEQPEMIP 883
                   +  +E      ++AL +  ++L                   K    E  ++  
Sbjct: 612  LQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFA 671

Query: 884  SQKQLAASIC---IQFAEHYLAEKEYDKAVQSYKDVFS--YLPTDNKVMLELAQLYLLQG 938
              ++  A I    +  A  Y+ +K+Y  AVQ Y++     Y   + +V+L LA+     G
Sbjct: 672  QVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCG 731

Query: 939  HLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKL 998
             L  C+Q    LL+      + +VLM ++    Q+      L   VL+    N      L
Sbjct: 732  KLQECKQ---TLLKARHVAPSDTVLMFNVALVLQR------LATSVLKDEKSN------L 776

Query: 999  IDLLRRSGKLEDIPAFFELAKKVSSRV 1025
             ++L    +LE    +F    KV  ++
Sbjct: 777  KEVLNAVKELELAHRYFSYLSKVGDKM 803



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 38/182 (20%), Positives = 74/182 (40%), Gaps = 16/182 (8%)

Query: 701 MANIYLQTL--------RDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPE----KA 748
           + N++LQTL        +++R   R      + L     +L   + + ++L  +    +A
Sbjct: 607 LGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREA 666

Query: 749 LEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQK---INGQDFLCCDLGKL 805
            +V+ +        + +   + H YV+  QY  A++ YE   +    +    +   L + 
Sbjct: 667 RDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARA 726

Query: 806 LLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLNKALD 865
           L K  K+ + ++ L +A  H    D   M N    L  LA      +K  + E LN   +
Sbjct: 727 LFKCGKLQECKQTLLKA-RHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVKE 785

Query: 866 LQ 867
           L+
Sbjct: 786 LE 787


>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
          Length = 519

 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 57/257 (22%), Positives = 108/257 (42%), Gaps = 34/257 (13%)

Query: 746 EKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDF-LCCDLGK 804
           +++LE++      +P  A    ++  +     ++  AIE Y  A K+N +D+ +  +LG 
Sbjct: 84  QESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGV 143

Query: 805 LLLKLKKVNKAEKVLKQAL---EHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLN 861
             + LK+ NKA+  L  AL    HD+              ++L K+   H  E     L+
Sbjct: 144 CYIYLKQFNKAQDQLHNALNLNRHDLT------------YIMLGKI---HLLEG---DLD 185

Query: 862 KALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLP 921
           KA+++  + ++  P E  E++ +   L           YL    Y KA +   +  +Y P
Sbjct: 186 KAIEVYKKAVEFSP-ENTELLTTLGLL-----------YLQLGIYQKAFEHLGNALTYDP 233

Query: 922 TDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLY 981
           T+ K +L    +    G  D+      ++             +    F K+K+ AAI+  
Sbjct: 234 TNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCL 293

Query: 982 HQVLEKAPDNFLVLHKL 998
            +    AP ++ +L+ L
Sbjct: 294 KRANYLAPFDWKILYNL 310



 Score = 34.3 bits (77), Expect = 0.81
 Identities = 44/205 (21%), Positives = 88/205 (42%), Gaps = 9/205 (4%)

Query: 585 KAGDYPEAIKTLKMVIKLPALKK--EEGRKFLRPSVQPSQRASILLELVEAL--RLNGEL 640
           KA ++P  ++    +I L  ++K  E  +  ++  +Q +Q        V+AL  RL G +
Sbjct: 25  KAPEFP-ILEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNI 83

Query: 641 HEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREK 700
            E+ ++ Q T         +N   +A    +L K    + +      L ++   +     
Sbjct: 84  QESLELFQ-TCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLG 142

Query: 701 MANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNP 760
           +  IYL+     +  +     L  H     T ++LG   +   + +KA+EVY +A   +P
Sbjct: 143 VCYIYLKQFNKAQDQLHNALNLNRH---DLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSP 199

Query: 761 HDASLASRIGHAYVKAHQYTEAIEY 785
            +  L + +G  Y++   Y +A E+
Sbjct: 200 ENTELLTTLGLLYLQLGIYQKAFEH 224


>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
            [Homo sapiens]
          Length = 774

 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 68/361 (18%), Positives = 142/361 (39%), Gaps = 36/361 (9%)

Query: 658  PEENRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIR 717
            P+ NR      +L+ S+   + A+ +L++ +     + +A   +A++  +  R +     
Sbjct: 437  PQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAE-E 495

Query: 718  CYRELCEHLPGP---HTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYV 774
             Y+   ++ P     H +   G  L+    PEKA+  Y +A + +P        +G  Y 
Sbjct: 496  IYQTGIKNCPDSSDLHNNY--GVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYR 553

Query: 775  KAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSM 834
               + + A E+Y+ A ++  +  +   LG L     +  +A ++ ++A        +   
Sbjct: 554  SLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAA------LQPS 607

Query: 835  MNDVKCLLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICI 894
              +++  L          KEA             ++   +  E+   +   + L+A    
Sbjct: 608  QRELRLALAQVLAVMGQTKEA------------EKMTNHIVSEETGCLECYRLLSAI--- 652

Query: 895  QFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLEL----AQLYLLQGHLDLCEQHCAIL 950
                 Y  ++ +DKA+ +        P D KV+ EL          Q  LD   +   + 
Sbjct: 653  -----YSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVA 707

Query: 951  LQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLED 1010
            +Q   +   A + M  +   K K+ +A   Y + L+  PD+ L+   L  L R   +L++
Sbjct: 708  VQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQE 767

Query: 1011 I 1011
            +
Sbjct: 768  V 768


>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
          Length = 1036

 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 65/282 (23%), Positives = 114/282 (40%), Gaps = 21/282 (7%)

Query: 755  AYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFL--CCDLGKLLLKLKKV 812
            A +QNP  A   S +G+ Y +  Q  EAIE+Y  A ++   DF+    +L   L+    +
Sbjct: 71   AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLK-PDFIDGYINLAAALVAAGDM 129

Query: 813  NKAEKVLKQALEHDIVQDIPSMMNDVKCLL-----------LLAKVYKSHKKEAVI-ETL 860
              A +    AL+++   D+  + +D+  LL              K  ++    AV    L
Sbjct: 130  EGAVQAYVSALQYN--PDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNL 187

Query: 861  NKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKE-YDKAVQSYKDVFSY 919
                + Q  I   +   +  +      L A I +    + L E   +D+AV +Y    S 
Sbjct: 188  GCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLG---NVLKEARIFDRAVAAYLRALSL 244

Query: 920  LPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAIN 979
             P    V   LA +Y  QG +DL        ++ + +   A   +A+ +  K     A +
Sbjct: 245  SPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAED 304

Query: 980  LYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKV 1021
             Y+  L   P +   L+ L ++ R  G +E+    +  A +V
Sbjct: 305  CYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEV 346



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 64/304 (21%), Positives = 125/304 (41%), Gaps = 23/304 (7%)

Query: 735  LGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKING 794
            LG+      + ++A+E Y  A R  P        +  A V A     A++ Y +A + N 
Sbjct: 85   LGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYN- 143

Query: 795  QDFLCC--DLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLL-LLAKVYKS- 850
             D  C   DLG LL  L ++ +A+    +A+E     +     +++ C+     +++ + 
Sbjct: 144  PDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQ--PNFAVAWSNLGCVFNAQGEIWLAI 201

Query: 851  -HKKEAVI---ETLNKALDL-----QSRILKRVP---LEQPEMIPSQKQLAASICIQFAE 898
             H ++AV      L+  ++L     ++RI  R     L    + P+   +  ++   + E
Sbjct: 202  HHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYE 261

Query: 899  HYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHE 958
              L     D A+ +Y+      P        LA     +G +   E      L+    H 
Sbjct: 262  QGLI----DLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHA 317

Query: 959  TASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELA 1018
             +   +A++   +   E A+ LY + LE  P+       L  +L++ GKL++    ++ A
Sbjct: 318  DSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEA 377

Query: 1019 KKVS 1022
             ++S
Sbjct: 378  IRIS 381



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 70/344 (20%), Positives = 131/344 (38%), Gaps = 43/344 (12%)

Query: 331 PSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEA--- 387
           P      + LG ++  + Q++EA+  Y  A++L  D + G   +    +  G +E A   
Sbjct: 76  PLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQA 135

Query: 388 -----EYRLEF------LKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTALLKEAVELH 436
                +Y  +       L  + K+LG+ E     +A     K    +   A+    +   
Sbjct: 136 YVSALQYNPDLYCVRSDLGNLLKALGRLE-----EAKACYLKAIETQPNFAVAWSNLGCV 190

Query: 437 FSSMQGIPLGSEYFEK---LDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVILNP 493
           F++   I L   +FEK   LDP FL       L    K+ R+  + V+  L+ +++  N 
Sbjct: 191 FNAQGEIWLAIHHFEKAVTLDPNFLDAYIN--LGNVLKEARIFDRAVAAYLRALSLSPNH 248

Query: 494 VVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFG 553
            V            +A V Y  G ++ A    +R +EL P   DA+  +      +G+  
Sbjct: 249 AVVHGN--------LACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVA 300

Query: 554 MCFHC----LELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKKEE 609
               C    L L  +H   + +        A    + G+  EA++  +  +++       
Sbjct: 301 EAEDCYNTALRLCPTHADSLNN-------LANIKREQGNIEEAVRLYRKALEVFPEFAAA 353

Query: 610 GRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINE 653
                    Q  +    L+   EA+R++    +A   M +T+ E
Sbjct: 354 HSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKE 397



 Score = 35.0 bits (79), Expect = 0.48
 Identities = 60/297 (20%), Positives = 114/297 (38%), Gaps = 29/297 (9%)

Query: 516 GELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLY 575
           G LE A++   + +E  P    A   +  ++ AQG   +  H  E  V+ +    D    
Sbjct: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDA--- 217

Query: 576 HLIKARALNKAGDYPEAIKTLKMVIKLP-----------ALKKEEGRKFLRPSVQPSQRA 624
           ++     L +A  +  A+      + L             +  E+G   +  ++   +RA
Sbjct: 218 YINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQG--LIDLAIDTYRRA 275

Query: 625 SIL--------LELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGN 676
             L          L  AL+  G + EA     +T      T  ++   +AN+     +GN
Sbjct: 276 IELQPHFPDAYCNLANALKEKGSVAEAEDCY-NTALRLCPTHADSLNNLANIKR--EQGN 332

Query: 677 VDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLL-L 735
           ++ A+ + R  L     +  A   +A++  Q  + +   +  Y+E     P    +   +
Sbjct: 333 IEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMH-YKEAIRISPTFADAYSNM 391

Query: 736 GDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKI 792
           G+ L  + + + AL+ Y  A + NP  A   S +   +  +    EAI  Y  A K+
Sbjct: 392 GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKL 448



 Score = 31.6 bits (70), Expect = 5.3
 Identities = 42/196 (21%), Positives = 72/196 (36%), Gaps = 14/196 (7%)

Query: 484 LKQVAVILNPVVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMC 543
           L++  +     ++ +P   D    M        +++ A     R ++++PA  DAH  + 
Sbjct: 367 LQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLA 426

Query: 544 QIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLP 603
            I+   GN           +       D P  +   A  L    D+ +  + +K ++ + 
Sbjct: 427 SIHKDSGNIPEAIASYRTALKLK---PDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIV 483

Query: 604 ALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRI 663
           A + E+ R    PSV P    S+L  L    R          +  D IN     P E+  
Sbjct: 484 ADQLEKNR---LPSVHPHH--SMLYPLSHGFR-KAIAERHGNLCLDKINVLHKPPYEH-- 535

Query: 664 TIANVDLVLSKGNVDV 679
                DL LS G + V
Sbjct: 536 ---PKDLKLSDGRLRV 548


>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
          Length = 1046

 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 65/282 (23%), Positives = 114/282 (40%), Gaps = 21/282 (7%)

Query: 755  AYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFL--CCDLGKLLLKLKKV 812
            A +QNP  A   S +G+ Y +  Q  EAIE+Y  A ++   DF+    +L   L+    +
Sbjct: 81   AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLK-PDFIDGYINLAAALVAAGDM 139

Query: 813  NKAEKVLKQALEHDIVQDIPSMMNDVKCLL-----------LLAKVYKSHKKEAVI-ETL 860
              A +    AL+++   D+  + +D+  LL              K  ++    AV    L
Sbjct: 140  EGAVQAYVSALQYN--PDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNL 197

Query: 861  NKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKE-YDKAVQSYKDVFSY 919
                + Q  I   +   +  +      L A I +    + L E   +D+AV +Y    S 
Sbjct: 198  GCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLG---NVLKEARIFDRAVAAYLRALSL 254

Query: 920  LPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAIN 979
             P    V   LA +Y  QG +DL        ++ + +   A   +A+ +  K     A +
Sbjct: 255  SPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAED 314

Query: 980  LYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKV 1021
             Y+  L   P +   L+ L ++ R  G +E+    +  A +V
Sbjct: 315  CYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEV 356



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 64/304 (21%), Positives = 125/304 (41%), Gaps = 23/304 (7%)

Query: 735  LGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKING 794
            LG+      + ++A+E Y  A R  P        +  A V A     A++ Y +A + N 
Sbjct: 95   LGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYN- 153

Query: 795  QDFLCC--DLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLL-LLAKVYKS- 850
             D  C   DLG LL  L ++ +A+    +A+E     +     +++ C+     +++ + 
Sbjct: 154  PDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQ--PNFAVAWSNLGCVFNAQGEIWLAI 211

Query: 851  -HKKEAVI---ETLNKALDL-----QSRILKRVP---LEQPEMIPSQKQLAASICIQFAE 898
             H ++AV      L+  ++L     ++RI  R     L    + P+   +  ++   + E
Sbjct: 212  HHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYE 271

Query: 899  HYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHE 958
              L     D A+ +Y+      P        LA     +G +   E      L+    H 
Sbjct: 272  QGLI----DLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHA 327

Query: 959  TASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELA 1018
             +   +A++   +   E A+ LY + LE  P+       L  +L++ GKL++    ++ A
Sbjct: 328  DSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEA 387

Query: 1019 KKVS 1022
             ++S
Sbjct: 388  IRIS 391



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 70/344 (20%), Positives = 131/344 (38%), Gaps = 43/344 (12%)

Query: 331 PSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEA--- 387
           P      + LG ++  + Q++EA+  Y  A++L  D + G   +    +  G +E A   
Sbjct: 86  PLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQA 145

Query: 388 -----EYRLEF------LKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTALLKEAVELH 436
                +Y  +       L  + K+LG+ E     +A     K    +   A+    +   
Sbjct: 146 YVSALQYNPDLYCVRSDLGNLLKALGRLE-----EAKACYLKAIETQPNFAVAWSNLGCV 200

Query: 437 FSSMQGIPLGSEYFEK---LDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVILNP 493
           F++   I L   +FEK   LDP FL       L    K+ R+  + V+  L+ +++  N 
Sbjct: 201 FNAQGEIWLAIHHFEKAVTLDPNFLDAYIN--LGNVLKEARIFDRAVAAYLRALSLSPNH 258

Query: 494 VVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFG 553
            V            +A V Y  G ++ A    +R +EL P   DA+  +      +G+  
Sbjct: 259 AVVHGN--------LACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVA 310

Query: 554 MCFHC----LELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKKEE 609
               C    L L  +H   + +        A    + G+  EA++  +  +++       
Sbjct: 311 EAEDCYNTALRLCPTHADSLNN-------LANIKREQGNIEEAVRLYRKALEVFPEFAAA 363

Query: 610 GRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINE 653
                    Q  +    L+   EA+R++    +A   M +T+ E
Sbjct: 364 HSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKE 407



 Score = 35.0 bits (79), Expect = 0.48
 Identities = 60/297 (20%), Positives = 114/297 (38%), Gaps = 29/297 (9%)

Query: 516 GELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLY 575
           G LE A++   + +E  P    A   +  ++ AQG   +  H  E  V+ +    D    
Sbjct: 171 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDA--- 227

Query: 576 HLIKARALNKAGDYPEAIKTLKMVIKLP-----------ALKKEEGRKFLRPSVQPSQRA 624
           ++     L +A  +  A+      + L             +  E+G   +  ++   +RA
Sbjct: 228 YINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQG--LIDLAIDTYRRA 285

Query: 625 SIL--------LELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGN 676
             L          L  AL+  G + EA     +T      T  ++   +AN+     +GN
Sbjct: 286 IELQPHFPDAYCNLANALKEKGSVAEAEDCY-NTALRLCPTHADSLNNLANIKR--EQGN 342

Query: 677 VDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLL-L 735
           ++ A+ + R  L     +  A   +A++  Q  + +   +  Y+E     P    +   +
Sbjct: 343 IEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMH-YKEAIRISPTFADAYSNM 401

Query: 736 GDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKI 792
           G+ L  + + + AL+ Y  A + NP  A   S +   +  +    EAI  Y  A K+
Sbjct: 402 GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKL 458



 Score = 31.6 bits (70), Expect = 5.3
 Identities = 42/196 (21%), Positives = 72/196 (36%), Gaps = 14/196 (7%)

Query: 484 LKQVAVILNPVVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMC 543
           L++  +     ++ +P   D    M        +++ A     R ++++PA  DAH  + 
Sbjct: 377 LQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLA 436

Query: 544 QIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLP 603
            I+   GN           +       D P  +   A  L    D+ +  + +K ++ + 
Sbjct: 437 SIHKDSGNIPEAIASYRTALKLK---PDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIV 493

Query: 604 ALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRI 663
           A + E+ R    PSV P    S+L  L    R          +  D IN     P E+  
Sbjct: 494 ADQLEKNR---LPSVHPHH--SMLYPLSHGFR-KAIAERHGNLCLDKINVLHKPPYEH-- 545

Query: 664 TIANVDLVLSKGNVDV 679
                DL LS G + V
Sbjct: 546 ---PKDLKLSDGRLRV 558


>gi|34304360 nephrocystin 3 [Homo sapiens]
          Length = 1330

 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 65/293 (22%), Positives = 128/293 (43%), Gaps = 29/293 (9%)

Query: 746  EKALEVYDEAY-RQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGK 804
            ++ALE+ + AY   +P+ A     +   Y K ++Y +A  + + + KI+          K
Sbjct: 1009 KQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQ---------K 1059

Query: 805  LLLKLKKVNKAEKVLKQALEHD---IVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLN 861
             + K   +     + ++AL+ +   + +D P     +  L +L   Y  +  E   + L 
Sbjct: 1060 AIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVL--YYLQNNLETADQFLK 1117

Query: 862  KALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSY-L 920
            ++L+++ R+L     + P+   S   LAA +C +  ++  AE+ Y++A+   +   +   
Sbjct: 1118 RSLEMRERVLGP---DHPDCAQSLNNLAA-LCNEKKQYDKAEELYERALDIRRRALAPDH 1173

Query: 921  PTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNH--------ETASVLMADLMFRKQ 972
            P+    +  LA LY   G LD       + ++  Q           TA V +A L  + +
Sbjct: 1174 PSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMK 1233

Query: 973  KHEAAINLYHQVLEKAPDNFLVLHKLI-DLLRRSGKLEDIPAFFELAKKVSSR 1024
            KH  A+ LY + L+   D+   +H  + + L+    L      FE A ++  R
Sbjct: 1234 KHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKR 1286


>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
           [Homo sapiens]
          Length = 836

 Score = 43.9 bits (102), Expect = 0.001
 Identities = 67/262 (25%), Positives = 113/262 (43%), Gaps = 46/262 (17%)

Query: 707 QTLRDRRLYIRCYRELCEHLPGPH------TSLL--LGDALMSILEPEKALEVYDEAYRQ 758
           +T   RR +++C     E+L  PH      TS L  LG         E+AL VY EA ++
Sbjct: 576 RTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635

Query: 759 NPHD---ASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDL--GKLLLKLKKVN 813
            P      SL + +G AY++  +  EA  +Y  + + +  D +   L  GKLL    + +
Sbjct: 636 MPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLR-SKTDHIPAHLTYGKLLALTGRKS 694

Query: 814 KAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLNKALDLQSRILKR 873
           +AEK+  +A+E D     P+  N   C +        H  + ++E        ++R+   
Sbjct: 695 EAEKLFLKAIELD-----PTKGN---CYM--------HYGQFLLE--------EARL--- 727

Query: 874 VPLEQPEMIPSQKQL-AASICIQF-AEHYLAEKEYDKAVQSYKDVFSYL-PTDNKVMLEL 930
             +E  EM     +L +    + F A H L +   ++A + Y D+ + L P     ++ L
Sbjct: 728 --IEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNL 785

Query: 931 AQLYLLQGHLDLCEQHCAILLQ 952
             +  L G L   E +    LQ
Sbjct: 786 GAILHLNGRLQKAEANYLRALQ 807


>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
           sapiens]
          Length = 830

 Score = 42.0 bits (97), Expect = 0.004
 Identities = 40/151 (26%), Positives = 64/151 (42%), Gaps = 2/151 (1%)

Query: 678 DVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPG-PHTSLLLG 736
           DVAL++L   L             A       R+  + I+ ++   +  P   +   LLG
Sbjct: 555 DVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLG 614

Query: 737 DALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQ- 795
              +   E +KAL  +  A R NP   +    +G  Y K  +++ A  +++ A  IN Q 
Sbjct: 615 HEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQS 674

Query: 796 DFLCCDLGKLLLKLKKVNKAEKVLKQALEHD 826
             L C +G +   LKK  KA   L +A+  D
Sbjct: 675 SVLLCHIGVVQHALKKSEKALDTLNKAIVID 705



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 37/158 (23%), Positives = 66/158 (41%), Gaps = 33/158 (20%)

Query: 309 CGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEAL-------------- 354
           C S Q    +   F +R     P+Y +  T LG+ F+L  ++ +AL              
Sbjct: 582 CFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHY 641

Query: 355 -LWYSEAM---KLDKDGMAGL-----------TGIILCHI--LEGHLEEAEYRLEFLKEV 397
             WY   M   K +K  +A +           + ++LCHI  ++  L+++E  L+ L + 
Sbjct: 642 NAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKA 701

Query: 398 QKSLGKSEVLIFLQA--LLMSRKHKGEEETTALLKEAV 433
                K+ +  F +A  L  + K+K   +    LK+ V
Sbjct: 702 IVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIV 739


>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
           sapiens]
          Length = 824

 Score = 42.0 bits (97), Expect = 0.004
 Identities = 40/151 (26%), Positives = 64/151 (42%), Gaps = 2/151 (1%)

Query: 678 DVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPG-PHTSLLLG 736
           DVAL++L   L             A       R+  + I+ ++   +  P   +   LLG
Sbjct: 549 DVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLG 608

Query: 737 DALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQ- 795
              +   E +KAL  +  A R NP   +    +G  Y K  +++ A  +++ A  IN Q 
Sbjct: 609 HEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQS 668

Query: 796 DFLCCDLGKLLLKLKKVNKAEKVLKQALEHD 826
             L C +G +   LKK  KA   L +A+  D
Sbjct: 669 SVLLCHIGVVQHALKKSEKALDTLNKAIVID 699



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 37/158 (23%), Positives = 66/158 (41%), Gaps = 33/158 (20%)

Query: 309 CGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEAL-------------- 354
           C S Q    +   F +R     P+Y +  T LG+ F+L  ++ +AL              
Sbjct: 576 CFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHY 635

Query: 355 -LWYSEAM---KLDKDGMAGL-----------TGIILCHI--LEGHLEEAEYRLEFLKEV 397
             WY   M   K +K  +A +           + ++LCHI  ++  L+++E  L+ L + 
Sbjct: 636 NAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKA 695

Query: 398 QKSLGKSEVLIFLQA--LLMSRKHKGEEETTALLKEAV 433
                K+ +  F +A  L  + K+K   +    LK+ V
Sbjct: 696 IVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIV 733


>gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sapiens]
          Length = 504

 Score = 39.7 bits (91), Expect = 0.019
 Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 23/123 (18%)

Query: 1200 DLEKSWLLLADIYCQGSKFDLALELLRRCV---QYNKSC---YKAYEYMGFIMEKEQS-- 1251
            D  +++  ++ +Y Q    +L+L  +R C+   Q +K C   YK  + +  ++E  +   
Sbjct: 220  DNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELI 279

Query: 1252 ----YKDAVTNYKLAWKYSHHANPAIGF-------KLAFNYLKDKKFVEAIEICNDVLRE 1300
                Y DA + Y+   K      P+I         ++   + KD+K VEAI +C++VL+ 
Sbjct: 280  RDGRYTDATSKYESVMK----TEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQM 335

Query: 1301 HPD 1303
             PD
Sbjct: 336  EPD 338



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 28/113 (24%), Positives = 52/113 (46%), Gaps = 14/113 (12%)

Query: 744 EPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLG 803
           +P +A+ V  E  +  P + +       AY+    Y EAI+ YE AQ+ N  D       
Sbjct: 321 KPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQI---- 376

Query: 804 KLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAV 856
                 + + KA+++LKQ+ + D  + +    N  K      ++ K+++K A+
Sbjct: 377 -----REGLEKAQRLLKQSQKRDYYKILGVKRNAKK-----QEIIKAYRKLAL 419



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 70/350 (20%), Positives = 129/350 (36%), Gaps = 64/350 (18%)

Query: 670 LVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIY----LQTLRDRRL----------- 714
           L+L +G +D A +  + +L       E +E  + +     +Q LR + L           
Sbjct: 114 LLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAA 173

Query: 715 --YIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHA 772
             ++    E+C  +       L  +  +   EP KA+     A +    +     +I   
Sbjct: 174 IAFLDKILEVC--VWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTL 231

Query: 773 YVKAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKK-VNKAEKVLKQALEHDIVQDI 831
           Y +   +  ++       K++     C    K + KL K +  AE++++     D     
Sbjct: 232 YYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKY 291

Query: 832 PSMMNDVKCLLLLAKVYKSHKKEAVIETLNK------ALDLQSRILKRVPLEQPEMIPSQ 885
            S+M     +      Y    KE +    +K      A+ + S +L+     +P+ + + 
Sbjct: 292 ESVMKTEPSIA----EYTVRSKERICHCFSKDEKPVEAIRVCSEVLQM----EPDNVNAL 343

Query: 886 KQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVM--LELAQLYLLQGHLDLC 943
           K  A        E YL E+ YD+A+Q Y+    +   D ++   LE AQ           
Sbjct: 344 KDRA--------EAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQR---------- 385

Query: 944 EQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQV-LEKAPDNF 992
                 LL+  Q  +   +L      R  K +  I  Y ++ L+  PDNF
Sbjct: 386 ------LLKQSQKRDYYKILGVK---RNAKKQEIIKAYRKLALQWHPDNF 426


>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
            protein) [Homo sapiens]
          Length = 543

 Score = 39.3 bits (90), Expect = 0.025
 Identities = 78/395 (19%), Positives = 151/395 (38%), Gaps = 90/395 (22%)

Query: 736  GDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQ 795
            G+  +S+   + AL+ Y EA + +PH+  L S    AY K   Y +A  Y +  + ++  
Sbjct: 11   GNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKA--YEDGCKTVD-- 66

Query: 796  DFLCCDLGK-------LLLKLKKVNKAEKVLKQALEHD-----IVQDIPSM--------- 834
              L  D GK        L  L +  +A++  ++ L+H+     + + + +M         
Sbjct: 67   --LKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKF 124

Query: 835  MNDVKCLLLLAKVYKSHK----------KEAVIETLNKALDL-----QSRILKRV----- 874
            MN      L  K+    +          +E + +  NK  DL       RI+  +     
Sbjct: 125  MNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLG 184

Query: 875  --------------------PLEQPEMIPSQKQLAASICIQFAEHYLAEKEY-----DKA 909
                                P ++ +  P ++ L  +      E  L    Y     D A
Sbjct: 185  VDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTA 244

Query: 910  VQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQT-EQNHE------TASV 962
            ++ Y       PT+   +   A +Y  +G  + C + C   ++   +N E       A  
Sbjct: 245  LKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYA 304

Query: 963  LMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVS 1022
             + +  F+++K++ AI+ Y++ L +        H+  D+L++  + E I    E    ++
Sbjct: 305  RIGNSYFKEEKYKDAIHFYNKSLAE--------HRTPDVLKKCQQAEKILKEQERLAYIN 356

Query: 1023 SRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARK 1057
              + LE      +G  C+  G   +A+K   +A K
Sbjct: 357  PDLALE---EKNKGNECFQKGDYPQAMKHYTEAIK 388


>gi|118402596 cell division cycle protein 23 [Homo sapiens]
          Length = 597

 Score = 38.5 bits (88), Expect = 0.043
 Identities = 66/306 (21%), Positives = 123/306 (40%), Gaps = 33/306 (10%)

Query: 676 NVDVALNMLRNILPKQSCYMEAREKMANI-YLQTLRDRRLYIRCYRELCE-HLPGPHTSL 733
           ++D AL++   +  +    +E  +  +N+ Y+++++    Y+     LCE       T  
Sbjct: 278 DIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLA--HNLCEIDKYRVETCC 335

Query: 734 LLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKIN 793
           ++G+      + EKA   +  A + NP      + +GH Y++    + AI+ Y  A ++N
Sbjct: 336 VIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVN 395

Query: 794 GQDFLC-CDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHK 852
            +D+     LG+    LK         ++A  H +        ND + L+ L + Y    
Sbjct: 396 KRDYRAWYGLGQTYEILKMPFYCLYYYRRA--HQL------RPNDSRMLVALGECY---- 443

Query: 853 KEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQ- 911
                E LN+ ++ +    +   +   E +   K   A +  Q  E   A + Y K +Q 
Sbjct: 444 -----EKLNQLVEAKKCYWRAYAVGDVEKMALVK--LAKLHEQLTESEQAAQCYIKYIQD 496

Query: 912 --SYKDVFSYLPTDNKVMLELAQLYL---LQGHLDLCEQHCAILLQTEQNHETASVLMAD 966
             S  ++  +L  ++     LAQ Y    L      C Q C     T +  E  ++L   
Sbjct: 497 IYSCGEIVEHL-EESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTRE--EGKALLRQI 553

Query: 967 LMFRKQ 972
           L  R Q
Sbjct: 554 LQLRNQ 559


>gi|224809432 transmembrane and tetratricopeptide repeat containing 3
            [Homo sapiens]
          Length = 914

 Score = 38.1 bits (87), Expect = 0.056
 Identities = 60/292 (20%), Positives = 120/292 (41%), Gaps = 26/292 (8%)

Query: 786  YEAAQKINGQDF-LCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLL 844
            + +A K+N  +  L  ++G  L   K   +A K   QA  H    DI + MN       +
Sbjct: 435  FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQAT-HVQPDDIGAHMN-------V 486

Query: 845  AKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAA------SICIQFAE 898
             + YK+         LN+  + +   +    L  P++IP +K  A       ++ I  A 
Sbjct: 487  GRTYKN---------LNRTKEAEESYMMAKSL-MPQIIPGKKYAARIAPNHLNVYINLAN 536

Query: 899  HYLA-EKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNH 957
               A E   ++A Q Y+   S  P   +  +   +L L        ++     L+ ++N+
Sbjct: 537  LIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNN 596

Query: 958  ETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFEL 1017
                  +A +    ++   A+  +++ LE  P + L L     +++ SG+++  P   + 
Sbjct: 597  ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKR 656

Query: 1018 AKKVSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHM 1069
                 +  PL+    +  G+      + NEA  ++ KA K     +SA++++
Sbjct: 657  LLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNL 708



 Score = 34.7 bits (78), Expect = 0.62
 Identities = 71/355 (20%), Positives = 132/355 (37%), Gaps = 41/355 (11%)

Query: 298 HLKKIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWY 357
           HL   I ++ L  +++  L        +     P +       G L +  N+  +A   Y
Sbjct: 527 HLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAY 586

Query: 358 SEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSR 417
            +A++LD++       + + HI    L+E    L+      +   K ++ +F  A++M  
Sbjct: 587 LKALELDRNNADLWYNLAIVHI---ELKEPNEALKNFNRALELNPKHKLALFNSAIVMQ- 642

Query: 418 KHKGEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAK---EYLLFCPKQPR 474
               E     L  EA +   S +   PL +  +  L    L    K   E  ++  K  +
Sbjct: 643 ----ESGEVKLRPEARKRLLSYINEEPLDANGYFNLG--MLAMDDKKDNEAEIWMKKAIK 696

Query: 475 LPGQIVSPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSGELEN-------------- 520
           L     S L   +A++ +   K   AL  P+ L   +RYY   ++               
Sbjct: 697 LQADFRSALFN-LALLYSQTAKELKAL--PI-LEELLRYYPDHIKGLILKGDILMNQKKD 752

Query: 521 ---AQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHL 577
              A+   +R LE+DP++V     +C +Y  + +      CL         +  H  Y  
Sbjct: 753 ILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCL----LETLALAPHEEY-- 806

Query: 578 IKARALNKAGDYPEAIKTLKMVIKLPALKKEEGRKFLRPSVQPSQRASILLELVE 632
              R LN   D   +   ++ +     +   EG+K    SV+  +  S   ++V+
Sbjct: 807 -IQRHLNIVRDKISSSSFIEPIFPTSKISSVEGKKIPTESVKEIRGESRQTQIVK 860


>gi|110225358 tetratricopeptide repeat domain 7A [Homo sapiens]
          Length = 858

 Score = 37.4 bits (85), Expect = 0.096
 Identities = 68/302 (22%), Positives = 116/302 (38%), Gaps = 33/302 (10%)

Query: 732  SLLLGDALMSILEPE---KALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEA 788
            SL   DA +   + E   KAL+  + A +  P D  +   +        Q + A+E  + 
Sbjct: 498  SLQATDATLKSKQDELHRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAMEQLQE 557

Query: 789  AQKINGQDFLCCDLGKLLLKLKKVNK-AEKVLKQAL-EHDIVQDIPSMMNDVKC------ 840
            A K+   D     L  LL   +K ++ A  V+  A+ EH   ++   M   VK       
Sbjct: 558  ALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHP--ENFNLMFTKVKLEQVLKG 615

Query: 841  ----------LLLLAKVYKSHKKEAVIE---TLNKALDLQSRILKRVPLEQPEMIPSQKQ 887
                      +L L +   S  +   +E   +  + L ++ +    + L       S  +
Sbjct: 616  PEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAHDADSGSR 675

Query: 888  LAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLD---LCE 944
             A+SI     E  ++E     +V   +       T  ++ L+ A+L++ Q HL     C 
Sbjct: 676  RASSIAASRLEEAMSELTMPSSVLK-QGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCI 734

Query: 945  QHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRR 1004
            Q  A L  T  +       +A++   K   E A  LY + L   PD   ++H L  +L R
Sbjct: 735  QEAAGLFPTSHSVLYMRGRLAEV---KGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSR 791

Query: 1005 SG 1006
             G
Sbjct: 792  LG 793


>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
          Length = 2803

 Score = 36.6 bits (83), Expect = 0.16
 Identities = 69/285 (24%), Positives = 107/285 (37%), Gaps = 45/285 (15%)

Query: 744  EPEKALEVYDEAYRQNPHDASLASRIGHAYVK---AHQYTEAIEYYEAAQKINGQDFLCC 800
            EPE   EV  +  +   H   +  +    Y K    H   EA++  + A +  G+D    
Sbjct: 1359 EPEPKDEVLQQKDKTLEHKEVVEPKDTAIYQKDEALHVKNEAVKQQDKALEQKGRDLEQK 1418

Query: 801  DLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETL 860
            D   L  K K +   +K L+   E D   +    + + K   L  K     +K+  +E  
Sbjct: 1419 DTA-LEQKDKALEPKDKDLE---EKDKALEQKDKIPEEKDKALEQKDTALEQKDKALEPK 1474

Query: 861  NKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAE-----------KEYDKA 909
            +K L+ + R+L     EQ E IP +K  A    ++  EH   E           ++ DKA
Sbjct: 1475 DKDLEQKDRVL-----EQKEKIPEEKDKALDQKVRSVEHKAPEDTVAEMKDRDLEQTDKA 1529

Query: 910  ------VQSYKDVFSYLPTDNKVMLELAQLYLLQGHLD-LCEQHCAILLQTEQNHETASV 962
                   Q  KD  S      K    L Q Y   G  D   EQ+   L +  Q  E  S+
Sbjct: 1530 PEQKHQAQEQKDKVS-----EKKDQALEQKYWALGQKDEALEQNIQALEENHQTQEQESL 1584

Query: 963  LMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGK 1007
            +  D   RK K          + EK+P+    + + ++ L    K
Sbjct: 1585 VQED-KTRKPK---------MLEEKSPEKVKAMEEKLEALLEKTK 1619


>gi|17149828 NMDA receptor regulated 1 [Homo sapiens]
          Length = 866

 Score = 36.6 bits (83), Expect = 0.16
 Identities = 52/240 (21%), Positives = 95/240 (39%), Gaps = 19/240 (7%)

Query: 707 QTLRDRRLYIRCYRELCEHLPGPHTSLLL----GDALMSILEPEKALEVYDEAYRQNPHD 762
           Q LR+  LY      LC +       L +    G+ L+ +   E A +VY     +NP +
Sbjct: 198 QVLREAGLYREALEHLCTYEKQICDKLAVEETKGELLLQLCRLEDAADVYRGLQERNPEN 257

Query: 763 ASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQA 822
            +    +  A +K     E ++ YE A     +  +     +L L      K ++ L + 
Sbjct: 258 WAYYKGLEKA-LKPANMLERLKIYEEAWTKYPRGLV---PRRLPLNFLSGEKFKECLDKF 313

Query: 823 LEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMI 882
           L  +  +  P + N ++ L      YK  +K A+IE L    +     LK   L  P   
Sbjct: 314 LRMNFSKGCPPVFNTLRSL------YKDKEKVAIIEELVVGYETS---LKSCRLFNPNDD 364

Query: 883 PSQKQLAASICIQF--AEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHL 940
             ++     + +Q+  A+HY    +   A++         PT  ++ L  A++Y   G++
Sbjct: 365 GKEEPPTTLLWVQYYLAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYKHAGNI 424


>gi|225735593 RNA polymerase II associated protein 3 isoform 2 [Homo
           sapiens]
          Length = 631

 Score = 36.2 bits (82), Expect = 0.21
 Identities = 28/117 (23%), Positives = 46/117 (39%), Gaps = 3/117 (2%)

Query: 882 IPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLD 941
           + SQK L      +    Y  + +YD+A+  Y       P +  +    A  Y       
Sbjct: 128 VDSQKALVLK---EKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFA 184

Query: 942 LCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKL 998
           + E  C + +   +++  A        F  QK E A   Y +VLE  P+NF   ++L
Sbjct: 185 VAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNEL 241


>gi|225735591 RNA polymerase II associated protein 3 isoform 1 [Homo
           sapiens]
          Length = 665

 Score = 36.2 bits (82), Expect = 0.21
 Identities = 28/117 (23%), Positives = 46/117 (39%), Gaps = 3/117 (2%)

Query: 882 IPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLD 941
           + SQK L      +    Y  + +YD+A+  Y       P +  +    A  Y       
Sbjct: 128 VDSQKALVLK---EKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFA 184

Query: 942 LCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKL 998
           + E  C + +   +++  A        F  QK E A   Y +VLE  P+NF   ++L
Sbjct: 185 VAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNEL 241



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 39/151 (25%), Positives = 68/151 (45%), Gaps = 22/151 (14%)

Query: 164 KKAIEYLEQGIQ-DTKDVLGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLK-- 220
           ++AIE   +GI  D  + L    +AM ++  Q Y EA +   Q  +  GS+  A   +  
Sbjct: 299 ERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGT 358

Query: 221 MQLFL-----ARQDWEQT--VEMGHRILEKDESNIDACQILTVHELAREGNMTTVSSLKT 273
            + FL     A+QD+E    +E G++    + S I         EL  +G+   V    T
Sbjct: 359 ARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIK-------KELIEKGHWDDVFLDST 411

Query: 274 QKATNHVRNLIKALETREPENPSLHLKKIIV 304
           Q+     +N++K ++       +  LKK+I+
Sbjct: 412 QR-----QNVVKPIDNPPHPGSTKPLKKVII 437


>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
            sapiens]
          Length = 833

 Score = 36.2 bits (82), Expect = 0.21
 Identities = 52/286 (18%), Positives = 107/286 (37%), Gaps = 60/286 (20%)

Query: 736  GDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQ 795
            G+ + +  + EKA E Y EA R +         IG  Y K ++  EA++ +         
Sbjct: 500  GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCF--------- 550

Query: 796  DFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEA 855
                       LKL  +                     + N  + L  +A +Y+      
Sbjct: 551  -----------LKLHAI---------------------LRNSAEVLYQIANIYE------ 572

Query: 856  VIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKD 915
            ++E  ++A++   +++  +P + P+++            +  E Y  E +  +A Q Y +
Sbjct: 573  LMENPSQAIEWLMQVVSVIPTD-PQVLS-----------KLGELYDREGDKSQAFQYYYE 620

Query: 916  VFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHE 975
             + Y P + +V+  L   Y+     +   Q+       +       +++A    R   ++
Sbjct: 621  SYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQ 680

Query: 976  AAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKV 1021
             A++ Y     K P+N   L  L+ L    G L+D   +    K++
Sbjct: 681  KALDTYKDTHRKFPENVECLRFLVRLCTDLG-LKDAQEYARKLKRL 725



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 35/158 (22%), Positives = 67/158 (42%), Gaps = 7/158 (4%)

Query: 637 NGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGN-VDVALNMLRNILPKQSCYM 695
           NG+  +A +  ++ +       E     + N+ L   K N +D AL+    +        
Sbjct: 506 NGDYEKAAEFYKEALRNDSSCTE----ALYNIGLTYEKLNRLDEALDCFLKLHAILRNSA 561

Query: 696 EAREKMANIYLQTLRDRRLYIRCYRELCEHLP-GPHTSLLLGDALMSILEPEKALEVYDE 754
           E   ++ANIY + + +    I    ++   +P  P     LG+      +  +A + Y E
Sbjct: 562 EVLYQIANIY-ELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYE 620

Query: 755 AYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKI 792
           +YR  P +  +   +G  Y+    + +AI+Y+E A  I
Sbjct: 621 SYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLI 658


>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
            sapiens]
          Length = 824

 Score = 36.2 bits (82), Expect = 0.21
 Identities = 52/286 (18%), Positives = 107/286 (37%), Gaps = 60/286 (20%)

Query: 736  GDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQ 795
            G+ + +  + EKA E Y EA R +         IG  Y K ++  EA++ +         
Sbjct: 491  GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCF--------- 541

Query: 796  DFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEA 855
                       LKL  +                     + N  + L  +A +Y+      
Sbjct: 542  -----------LKLHAI---------------------LRNSAEVLYQIANIYE------ 563

Query: 856  VIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKD 915
            ++E  ++A++   +++  +P + P+++            +  E Y  E +  +A Q Y +
Sbjct: 564  LMENPSQAIEWLMQVVSVIPTD-PQVLS-----------KLGELYDREGDKSQAFQYYYE 611

Query: 916  VFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHE 975
             + Y P + +V+  L   Y+     +   Q+       +       +++A    R   ++
Sbjct: 612  SYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQ 671

Query: 976  AAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKV 1021
             A++ Y     K P+N   L  L+ L    G L+D   +    K++
Sbjct: 672  KALDTYKDTHRKFPENVECLRFLVRLCTDLG-LKDAQEYARKLKRL 716



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 35/158 (22%), Positives = 67/158 (42%), Gaps = 7/158 (4%)

Query: 637 NGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGN-VDVALNMLRNILPKQSCYM 695
           NG+  +A +  ++ +       E     + N+ L   K N +D AL+    +        
Sbjct: 497 NGDYEKAAEFYKEALRNDSSCTE----ALYNIGLTYEKLNRLDEALDCFLKLHAILRNSA 552

Query: 696 EAREKMANIYLQTLRDRRLYIRCYRELCEHLP-GPHTSLLLGDALMSILEPEKALEVYDE 754
           E   ++ANIY + + +    I    ++   +P  P     LG+      +  +A + Y E
Sbjct: 553 EVLYQIANIY-ELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYE 611

Query: 755 AYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKI 792
           +YR  P +  +   +G  Y+    + +AI+Y+E A  I
Sbjct: 612 SYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLI 649


>gi|15619013 43 kD receptor-associated protein of the synapse
           isoform 1 [Homo sapiens]
          Length = 412

 Score = 35.0 bits (79), Expect = 0.48
 Identities = 54/223 (24%), Positives = 92/223 (41%), Gaps = 48/223 (21%)

Query: 719 YRELCEHLPGPHT--------SLLLGDALMSILEPEKALEVYDEA--YRQNPHDASLASR 768
           Y + C  LPG           SL +G+A + +   +KALE +++A  Y  N  DA L  R
Sbjct: 105 YCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECR 164

Query: 769 I----GHAYVKAHQYTEAIEY-YEAAQKING------------QDFLCCDLGKLLLKL-K 810
           +    G  Y +   Y +A+ +  +AA+ +N               +      +LL +L  
Sbjct: 165 VCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAYRLLGRLGS 224

Query: 811 KVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSH-KKEAVIETLNKALDLQSR 869
            +   E+ +K AL+H    D P       CLL  A +++S    E      + A+ + + 
Sbjct: 225 AMECCEESMKIALQHG---DRPL---QALCLLCFADIHRSRGDLETAFPRYDSAMSIMTE 278

Query: 870 ILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQS 912
           I  R+          Q Q    +    A+ ++A K  DKA+ +
Sbjct: 279 IGNRL---------GQVQALLGV----AKCWVARKALDKALDA 308


>gi|209976994 adenylate cyclase 10 [Homo sapiens]
          Length = 1610

 Score = 34.7 bits (78), Expect = 0.62
 Identities = 38/152 (25%), Positives = 65/152 (42%), Gaps = 22/152 (14%)

Query: 858  ETLNKALDLQSRILKRVPLEQPEMIPSQ----KQLAASICIQFAEHYLAEKEYDKAVQSY 913
            E   K L+    +L ++     ++IP +    +++   + +  A H+LA  E DKA+  +
Sbjct: 1029 EIREKILNFFDHVLTKMKTSDEDIIPLESCQCEEILEIVILPLAHHFLALGENDKALYYF 1088

Query: 914  KDVFS-YLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQ 972
             ++ S YL   +  M   A +YL +G           LL+T +  ++ S       F   
Sbjct: 1089 LEIASAYLIFCDNYM---AYMYLNEGQK---------LLKTLKKDKSWSQTFESATFYSL 1136

Query: 973  KHEAAINLYHQVLEKAPDNFLVLHKLIDLLRR 1004
            K E   N+   VL K      +L K + LL R
Sbjct: 1137 KGEVCFNMGQIVLAKK-----MLRKALKLLNR 1163


>gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens]
          Length = 843

 Score = 34.7 bits (78), Expect = 0.62
 Identities = 21/94 (22%), Positives = 45/94 (47%)

Query: 908  KAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADL 967
            KA+ +++   S  PTD++    LA    +   +     +    LQ + +   +  L+A L
Sbjct: 499  KALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALL 558

Query: 968  MFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDL 1001
            +  ++ +  A+N+    L + P+NF++L   + L
Sbjct: 559  LSAQKHYHDALNIIDMALSEYPENFILLFSKVKL 592


>gi|4503729 FK506 binding protein 52 [Homo sapiens]
          Length = 459

 Score = 33.9 bits (76), Expect = 1.1
 Identities = 51/204 (25%), Positives = 79/204 (38%), Gaps = 43/204 (21%)

Query: 1110 EKLLREFYPHSDSSQTQLRLLQGLCRLATREKANMEAALGSFIQIAQAEKDSVPALLALA 1169
            E  L  +Y      Q +LR   G       E  N++   G    I + EK    +++ L 
Sbjct: 171  EVALEGYYKDKLFDQRELRFEIG-------EGENLDLPYGLERAIQRMEKGE-HSIVYLK 222

Query: 1170 QAYVFLK------QIP-----KARMQLKRL--AKTPWVLSEAEDLEKSWLLL--ADIYCQ 1214
             +Y F        QIP     K  + LK    AK  W ++  E LE+S ++     +Y +
Sbjct: 223  PSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFK 282

Query: 1215 GSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIG 1274
              K+  AL   ++ V +              +E E S+ +       A + + H N    
Sbjct: 283  EGKYKQALLQYKKIVSW--------------LEYESSFSNEEAQKAQALRLASHLN---- 324

Query: 1275 FKLAFNYLKDKKFVEAIEICNDVL 1298
              LA  +LK + F  AIE CN  L
Sbjct: 325  --LAMCHLKLQAFSAAIESCNKAL 346


>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 33.5 bits (75), Expect = 1.4
 Identities = 61/310 (19%), Positives = 118/310 (38%), Gaps = 64/310 (20%)

Query: 773  YVKAHQYTEAIEYYEAAQKINGQD---------FLCCDLGKLLLKLKKVNKAEKVLKQAL 823
            YV++    E I+YYE+  KI  ++         F  C  G +  KL K+  A        
Sbjct: 885  YVESDLPQEVIKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSA-------- 936

Query: 824  EHDIVQDIPSMMNDVKCLLLLAKVYKS-----HKKEAVIETLNKALDLQSRILKRVPLEQ 878
                       MND++ ++LL  ++ +     H      + +N+ALD  + I K      
Sbjct: 937  -----------MNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHK------ 979

Query: 879  PEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQG 938
                    +      +  AE Y  +K+   A+ +Y       PTD  +     ++Y +  
Sbjct: 980  ------YNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITN 1033

Query: 939  HLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKH--------EAAINLYHQVLEKAPD 990
             +   +     +    +   T ++L   L + + ++         A +N+ HQ   +A  
Sbjct: 1034 KVLAIDDFSKCIFYDPK--RTDALLKRGLFYCENENWFAAIEDFTALLNIDHQ-NSQARG 1090

Query: 991  NFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYCWHIGQPNEALK 1050
             +L++ K  DL + +     I    E+ K +S   P++    Y    +C +  +  E L 
Sbjct: 1091 QYLLMMKYYDLAKFT-----IYQIAEMDKGLSELSPMQQALIYS---FCENHDKAIEVLD 1142

Query: 1051 FLNKARKDST 1060
             ++  R + T
Sbjct: 1143 GISWNRAEMT 1152


>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 33.5 bits (75), Expect = 1.4
 Identities = 61/310 (19%), Positives = 118/310 (38%), Gaps = 64/310 (20%)

Query: 773  YVKAHQYTEAIEYYEAAQKINGQD---------FLCCDLGKLLLKLKKVNKAEKVLKQAL 823
            YV++    E I+YYE+  KI  ++         F  C  G +  KL K+  A        
Sbjct: 885  YVESDLPQEVIKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSA-------- 936

Query: 824  EHDIVQDIPSMMNDVKCLLLLAKVYKS-----HKKEAVIETLNKALDLQSRILKRVPLEQ 878
                       MND++ ++LL  ++ +     H      + +N+ALD  + I K      
Sbjct: 937  -----------MNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHK------ 979

Query: 879  PEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQG 938
                    +      +  AE Y  +K+   A+ +Y       PTD  +     ++Y +  
Sbjct: 980  ------YNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITN 1033

Query: 939  HLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKH--------EAAINLYHQVLEKAPD 990
             +   +     +    +   T ++L   L + + ++         A +N+ HQ   +A  
Sbjct: 1034 KVLAIDDFSKCIFYDPK--RTDALLKRGLFYCENENWFAAIEDFTALLNIDHQ-NSQARG 1090

Query: 991  NFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYCWHIGQPNEALK 1050
             +L++ K  DL + +     I    E+ K +S   P++    Y    +C +  +  E L 
Sbjct: 1091 QYLLMMKYYDLAKFT-----IYQIAEMDKGLSELSPMQQALIYS---FCENHDKAIEVLD 1142

Query: 1051 FLNKARKDST 1060
             ++  R + T
Sbjct: 1143 GISWNRAEMT 1152


>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
            sapiens]
          Length = 1614

 Score = 33.5 bits (75), Expect = 1.4
 Identities = 61/310 (19%), Positives = 118/310 (38%), Gaps = 64/310 (20%)

Query: 773  YVKAHQYTEAIEYYEAAQKINGQD---------FLCCDLGKLLLKLKKVNKAEKVLKQAL 823
            YV++    E I+YYE+  KI  ++         F  C  G +  KL K+  A        
Sbjct: 885  YVESDLPQEVIKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSA-------- 936

Query: 824  EHDIVQDIPSMMNDVKCLLLLAKVYKS-----HKKEAVIETLNKALDLQSRILKRVPLEQ 878
                       MND++ ++LL  ++ +     H      + +N+ALD  + I K      
Sbjct: 937  -----------MNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHK------ 979

Query: 879  PEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQG 938
                    +      +  AE Y  +K+   A+ +Y       PTD  +     ++Y +  
Sbjct: 980  ------YNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITN 1033

Query: 939  HLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKH--------EAAINLYHQVLEKAPD 990
             +   +     +    +   T ++L   L + + ++         A +N+ HQ   +A  
Sbjct: 1034 KVLAIDDFSKCIFYDPK--RTDALLKRGLFYCENENWFAAIEDFTALLNIDHQ-NSQARG 1090

Query: 991  NFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYCWHIGQPNEALK 1050
             +L++ K  DL + +     I    E+ K +S   P++    Y    +C +  +  E L 
Sbjct: 1091 QYLLMMKYYDLAKFT-----IYQIAEMDKGLSELSPMQQALIYS---FCENHDKAIEVLD 1142

Query: 1051 FLNKARKDST 1060
             ++  R + T
Sbjct: 1143 GISWNRAEMT 1152


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,190,327
Number of Sequences: 37866
Number of extensions: 1989244
Number of successful extensions: 6165
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 5879
Number of HSP's gapped (non-prelim): 284
length of query: 1321
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1207
effective length of database: 13,930,794
effective search space: 16814468358
effective search space used: 16814468358
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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