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Search of human proteins with 157388975
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157388975 coiled-coil domain containing 99 [Homo sapiens]
(605 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157388975 coiled-coil domain containing 99 [Homo sapiens] 1165 0.0
gi|55770834 centromere protein F [Homo sapiens] 91 2e-18
gi|71061468 centromere protein E [Homo sapiens] 91 3e-18
gi|58530840 desmoplakin isoform I [Homo sapiens] 89 1e-17
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 88 2e-17
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 85 2e-16
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 85 2e-16
gi|31982906 cingulin-like 1 [Homo sapiens] 84 5e-16
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 83 6e-16
gi|4506751 restin isoform a [Homo sapiens] 83 6e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 83 6e-16
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 83 8e-16
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 82 2e-15
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 81 2e-15
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 81 2e-15
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 81 2e-15
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 81 2e-15
gi|45439327 periplakin [Homo sapiens] 81 2e-15
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 81 3e-15
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 81 3e-15
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 80 5e-15
gi|21735548 centrosomal protein 2 [Homo sapiens] 80 7e-15
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 80 7e-15
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 79 9e-15
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 79 1e-14
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 79 1e-14
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 78 3e-14
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 77 6e-14
gi|109134347 NY-REN-58 antigen [Homo sapiens] 77 6e-14
gi|109134355 NY-REN-58 antigen [Homo sapiens] 77 6e-14
>gi|157388975 coiled-coil domain containing 99 [Homo sapiens]
Length = 605
Score = 1165 bits (3015), Expect = 0.0
Identities = 605/605 (100%), Positives = 605/605 (100%)
Query: 1 MEADIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKY 60
MEADIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKY
Sbjct: 1 MEADIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKY 60
Query: 61 TLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVEL 120
TLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVEL
Sbjct: 61 TLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVEL 120
Query: 121 DEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTL 180
DEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTL
Sbjct: 121 DEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTL 180
Query: 181 KEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQL 240
KEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQL
Sbjct: 181 KEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQL 240
Query: 241 DQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQI 300
DQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQI
Sbjct: 241 DQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQI 300
Query: 301 ATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGT 360
ATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGT
Sbjct: 301 ATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGT 360
Query: 361 LEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLS 420
LEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLS
Sbjct: 361 LEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLS 420
Query: 421 ESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRL 480
ESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRL
Sbjct: 421 ESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRL 480
Query: 481 PPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPA 540
PPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPA
Sbjct: 481 PPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPA 540
Query: 541 DAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKETCKKLHPILYVSSKSTPET 600
DAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKETCKKLHPILYVSSKSTPET
Sbjct: 541 DAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKETCKKLHPILYVSSKSTPET 600
Query: 601 QCPQQ 605
QCPQQ
Sbjct: 601 QCPQQ 605
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 91.3 bits (225), Expect = 2e-18
Identities = 150/665 (22%), Positives = 276/665 (41%), Gaps = 136/665 (20%)
Query: 5 IITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYT--- 61
++++ + L+E E+ ++ + VE LQNQL + + + E K T
Sbjct: 2232 LLSSFKSLLEEKEQAEIQIKEESKTAVEM---LQNQLKELNEAVAALCGDQEIMKATEQS 2288
Query: 62 ----LQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLK 117
++ E +L++ +E L EA +++Q L++L+E S H + LK ++E L+
Sbjct: 2289 LDPPIEEEHQLRNS-IEKLRARLEADEKKQLCVLQQLKE--SEHHA---DLLKGRVENLE 2342
Query: 118 VELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMK 177
EL+ AR +++ + ++ K E+ + ++ E M+ + L++++ + S K
Sbjct: 2343 RELEIARTNQEHAALEAENSKG-------EVETLKAKI-EGMTQSLRGLELDVVTIRSEK 2394
Query: 178 TTLKEEVNELQYRQEQLELL---ITNLMRQVDRLKEEKEEREKEAV-------------- 220
L E+ + Q R +LE++ N++++ ++ K + +E+ A+
Sbjct: 2395 ENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERV 2454
Query: 221 -SYYNALEKARVANQDLQVQ--------------LDQALQQALDPNSKGNSLFAEVEDRR 265
+ +N E + Q+L Q LD+A + S N L EVED +
Sbjct: 2455 AALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK 2514
Query: 266 AAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQ 325
+E++ E++ R+K QI + QE+L++ L Q
Sbjct: 2515 QKLEKK------------------DEEISRLKNQI-------------QDQEQLVSKLSQ 2543
Query: 326 KNGEIKHLLGEIRNLEKFKNLYDSMESKPSV---DSGTLEDNTYYTDLLQMKLDNLNKEI 382
GE H L + +NLE +NL +E K V + +L+D ++LQ NL E+
Sbjct: 2544 VEGE--HQLWKEQNLE-LRNLTVELEQKIQVLQSKNASLQDT---LEVLQSSYKNLENEL 2597
Query: 383 ESTK---------------GELSIQR-----MKALFESQRALDIERKLFANERCLQLSES 422
E TK E +QR + E Q L E+ A E L L E
Sbjct: 2598 ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEI 2657
Query: 423 ENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPP 482
++ K D+LK E T+E LKK + + D K+ V ++ RL
Sbjct: 2658 KSSK-----DQLK-----ELTLENSELKKSLDCMHKD-QVEKEGKVREEIAEYQL-RLHE 2705
Query: 483 QKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPH--KNLPVDMQLKKEKKCVKLIGVPA 540
+++ Q+ L D N Q E + Y ++ + +++ L K K + A
Sbjct: 2706 AEKKHQAL---LLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKA 2762
Query: 541 DAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKETCKKLHPILYVSSKSTPET 600
+ L E ++ + + K + E +GK KL ++CK+L + K +
Sbjct: 2763 TTQILEELKKTKMDNLKYVNQLKKENERAQGK---MKLLIKSCKQLEEEKEILQKELSQL 2819
Query: 601 QCPQQ 605
Q Q+
Sbjct: 2820 QAAQE 2824
Score = 85.5 bits (210), Expect = 1e-16
Identities = 150/644 (23%), Positives = 275/644 (42%), Gaps = 112/644 (17%)
Query: 6 ITNLRCRLKEAEEERL----KAAQYGLQLVESQNEL---QNQLDKCRNEMMTMTESYEQ- 57
I L RL+ E+E K + LQL +++ EL + L+KCR+E++ T Y+Q
Sbjct: 294 INELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQA 353
Query: 58 -EKYTLQREVELKSRMLESLSCECE-------AIKQQQKMHLEKLEEQLSRSH------- 102
KYT E +LK ++ E LSC+ + +++Q+ K ++ +E+LSR
Sbjct: 354 STKYT-ALEQKLK-KLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLD 411
Query: 103 ----------GQEVNELKTKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMS 152
QE+ + K L+ ELD+ ++QL++ ++ K+ L C++E+ S
Sbjct: 412 QECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL-CRAEQAFQAS 470
Query: 153 E-------RVQESMSSEMLALQI-------ELTEMESMKTTLKEEVNELQYRQEQLELLI 198
+ R E M E L+ E+ +E+ +K+ +N+ Q E+++
Sbjct: 471 QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKN 530
Query: 199 TNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLD---QALQQALDPNSKGN 255
T+ + L+E+ ++E LEK ++A DL+ Q D L++ + N
Sbjct: 531 TSQETMLRDLQEKINQQENSL-----TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLN 585
Query: 256 SLFAEVEDRRAAMERQLISMKVKYQSLKKQ-NVFNREQMQRMKLQIATLLQMKGSQTEFE 314
++ E A+ L K +Y+ LK++ +F+ + + KL + + Q++
Sbjct: 586 DKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKIN 645
Query: 315 QQERLLAMLEQKNGEIKHLLGEIRNLE--------KFKNLYDSMESKPSVDSGT------ 360
E L + K+ E +R LE + +NL++ ++SK SV+ T
Sbjct: 646 HLETCLKTQQIKSHEYNE---RVRTLEMDRENLSVEIRNLHNVLDSK-SVEVETQKLAYM 701
Query: 361 -LEDNTYYTDLL-QMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQ 418
L+ ++D Q +++N+ + G++ K S +D +RC Q
Sbjct: 702 ELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD-------KDRCYQ 754
Query: 419 LSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVY 478
+E LR D LK K T E +R +L D A N + GE
Sbjct: 755 DLHAEYESLR---DLLKSKDASLVTNE----DHQRSLLAFDQQPAMHHSFAN--IIGEQG 805
Query: 479 RLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGV 538
+P ++ E + + N+ L+ V + SL K + D+Q K+C +L+ +
Sbjct: 806 SMPSERSECRLEADQSPKNSAILQNRVD--SLEFSLESQKQMNSDLQ----KQCEELVQI 859
Query: 539 PADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKET 582
+ E + AE Q+ V E + SKL+++T
Sbjct: 860 KGEIE-----------ENLMKAEQMHQSFVAETSQRISKLQEDT 892
Score = 77.4 bits (189), Expect = 4e-14
Identities = 134/619 (21%), Positives = 257/619 (41%), Gaps = 122/619 (19%)
Query: 36 ELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLE 95
+++N+L + R+E ++ E L E +L+ E L E + +Q+ + LE
Sbjct: 1899 DVENELSRIRSEKASI------EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVC--LE 1950
Query: 96 EQLSRSHGQEVNELKTKIE---KLKVELDEARLSEKQLKHQVD-HQKELLSCKSEELRVM 151
E+LS + N+L+ +++ K LD+ K+ +++ HQ E L C ++V
Sbjct: 1951 EELSVVTSER-NQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHC----IQVA 2005
Query: 152 SERVQESMSSEML-ALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKE 210
V+E +E+L L +++E+ KT L+E++ L+ + L L L Q+ +L +
Sbjct: 2006 EAEVKEK--TELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNK 2063
Query: 211 EKE--------------EREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNS 256
EKE E + E ++ ALE A V + ++L ++
Sbjct: 2064 EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEK 2123
Query: 257 LFAEVE----------DRRAAMERQLISMKVKYQSLKKQNVFNREQM-------QRMKLQ 299
L +E ++ ER+ S+K K ++L+++ + E + K +
Sbjct: 2124 LRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAE 2183
Query: 300 IATLL----QMKGSQTEFE--------QQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLY 347
+ TL +M S FE ++E L +++K G++ L + L FK+L
Sbjct: 2184 VETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL---DKLLSSFKSL- 2239
Query: 348 DSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIE 407
+E K + E++ ++LQ +L LN+ + + G+ I +
Sbjct: 2240 --LEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMK-------------- 2283
Query: 408 RKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRRE------------- 454
A E+ L E +LR +++L+ + E +E ++ VL++ +E
Sbjct: 2284 ----ATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVE 2339
Query: 455 ----VLPVDITTAKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTP 510
L + T + A + GEV L K + + SL L +
Sbjct: 2340 NLERELEIARTNQEHAALEAENSKGEVETL---KAKIEGMTQSLRGLELDV--------- 2387
Query: 511 VVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEAL---SERSGNTPNSPRLAAESKLQTE 567
V S +NL ++Q K++++ +L + + E + E+ A LQT+
Sbjct: 2388 VTIRSEKENLTNELQ-KEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ 2446
Query: 568 VKEGKETSSKL--EKETCK 584
+KE E + L ++E CK
Sbjct: 2447 LKELNERVAALHNDQEACK 2465
Score = 61.6 bits (148), Expect = 2e-09
Identities = 66/291 (22%), Positives = 128/291 (43%), Gaps = 44/291 (15%)
Query: 14 KEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRML 73
KE E +R + + + E Q EL + ++ E+ + E + K L+ S +
Sbjct: 2617 KETELQR-EMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELK 2675
Query: 74 ESLSC-ECEAIKQQQKMHLEKLEEQLSRSHGQEVN-------------ELKTKIEKL--- 116
+SL C + ++++ K+ E E QL ++ + E++T EKL
Sbjct: 2676 KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSK 2735
Query: 117 -------KVELDEARLSEKQLKHQVDHQ----KELLSCKSEELRVMSE--RVQESMSSEM 163
K+E+D + S+++L + + +EL K + L+ +++ + E +M
Sbjct: 2736 EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM 2795
Query: 164 LALQIELTEMESMKTTLKEEVNELQYRQEQ------LELLITNLMRQVDRLKEEKEEREK 217
L ++E K L++E+++LQ QE+ ++ + L ++ LKE EE+ K
Sbjct: 2796 KLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTK 2855
Query: 218 EAVSYYN-------ALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEV 261
EA Y + + EK A + L+ Q+ Q +S+G+ L V
Sbjct: 2856 EADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPV 2906
Score = 51.6 bits (122), Expect = 2e-06
Identities = 114/538 (21%), Positives = 203/538 (37%), Gaps = 83/538 (15%)
Query: 36 ELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLE 95
EL+ QLDK + E QR+ +L S E KQ+QK+ EK E
Sbjct: 22 ELEGQLDKLKKEKQ-------------QRQFQLDS-------LEAALQKQKQKVENEKTE 61
Query: 96 EQLSRSHGQEVNELKTKIEKLKVELD-EARLSEKQL----------KHQVDH-QKELLSC 143
+ Q + E+ +EK K ++ E ++ E Q+ K Q++ ++EL C
Sbjct: 62 GTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRC 121
Query: 144 KSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMR 203
KSE ER Q++ S ++L T + T L Y + E L +
Sbjct: 122 KSE-----LERSQQAAQSADVSLNPCNTPQKIFTTPL---TPSQYYSGSKYEDLKEKYNK 173
Query: 204 QVDRLKE-EKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVE 262
+V+ K E E + +A L +A + ++D + QA +
Sbjct: 174 EVEERKRLEAEVKALQAKKASQTLPQATMNHRD--IARHQASSSVFSWQQEKTPSHLSSN 231
Query: 263 DRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAM 322
+R + R Y S +++ +R +Q K S + LL
Sbjct: 232 SQRTPIRR---DFSASYFSGEQEVTPSRSTLQIGK------RDANSSFFDNSSSPHLLDQ 282
Query: 323 LEQKNGEIKHLLGEIR------------NLEKFKNLYDSMESKPSVD-----------SG 359
L+ +N E+++ + E+ + KF+ L +E K V+
Sbjct: 283 LKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLE-KAKVELIEKEKVLNKCRD 341
Query: 360 TLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQL 419
L T D K L ++++ +LS QR A ES R +E+K+ E+ Q
Sbjct: 342 ELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNA--ESARC-SLEQKIKEKEKEFQE 398
Query: 420 SESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVD---ITTAKDACVNN-SALGG 475
S + LD+ ++ + T E+ K VL + +T+ K NN
Sbjct: 399 ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQ 458
Query: 476 EVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCV 533
++ R + +Q N L + +++K ++ + ++ +LK K+C+
Sbjct: 459 KLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516
Score = 49.3 bits (116), Expect = 1e-05
Identities = 61/309 (19%), Positives = 130/309 (42%), Gaps = 62/309 (20%)
Query: 25 QYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVEL---------------- 68
Q + L++ N +D+ + +++ Y+QEK L + E
Sbjct: 988 QEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQ 1047
Query: 69 -KSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSE 127
K+ LE L EC ++ + +K LE+L+E ++ H + + +L E+
Sbjct: 1048 EKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEER------------ 1095
Query: 128 KQLKHQVDHQKELLSCKSEELRVMSERV--QESMSSEMLALQIELTEMESMKTTLKEEVN 185
+Q +L ++ + + SE Q + SE L+ E+ ++ + +++EVN
Sbjct: 1096 --------NQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVN 1147
Query: 186 ELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQ-DLQVQLDQAL 244
+L EQL +V + K E + E E + + E+ NQ + + Q+D +
Sbjct: 1148 DLLQENEQL--------MKVMKTKHECQNLESEPIR-NSVKERESERNQCNFKPQMDLEV 1198
Query: 245 QQ-ALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMK--LQIA 301
++ +LD + +E L + ++K Q +K+ + ++Q ++ L+ +
Sbjct: 1199 KEISLD----------SYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETS 1248
Query: 302 TLLQMKGSQ 310
L M+ +
Sbjct: 1249 NLQDMQSQE 1257
Score = 47.8 bits (112), Expect = 3e-05
Identities = 124/591 (20%), Positives = 227/591 (38%), Gaps = 137/591 (23%)
Query: 14 KEAEE-ERLKAAQYGLQLVESQNEL----QNQLDKCRNEMMTMTESYEQEKYTLQREVEL 68
KE EE +RL+A LQ ++ L N D R++ + S++QEK
Sbjct: 173 KEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEK--------- 223
Query: 69 KSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEK 128
Q+ + + S QEV ++ ++ K + + +
Sbjct: 224 ---------TPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNS 274
Query: 129 QLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQ 188
H +D L +++ELR ++ E L L+++ E E +K +VN+ Q
Sbjct: 275 SSPHLLDQ----LKAQNQELR---NKINE------LELRLQGHEKE-----MKGQVNKFQ 316
Query: 189 YRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQAL 248
Q QLE L+ + L + ++E + Y A K Q L+ + Q
Sbjct: 317 ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQ 376
Query: 249 DPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQ-------------------NVFN 289
+ S SL +++++ + +L + +Q+L ++ NV
Sbjct: 377 NAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQ 436
Query: 290 RE--QMQRMKLQIATLL----------------------QMKGSQTEFEQQERLL-AMLE 324
E ++ +K Q+ L +++ S E +++ LL + E
Sbjct: 437 AELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE 496
Query: 325 QKNGEIKHLLGEIRN----LEKFKNLYDSMESKPSVDSGTLED---------NTYYTDLL 371
QK E+ HL E++N L + +N + M++K + L D N+ + L
Sbjct: 497 QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKL 556
Query: 372 QMKLDNLNKE--------------IESTKGELS--IQRMKALF-------ESQRALDIER 408
++ + +L K+ IE +LS + KAL + L E+
Sbjct: 557 KLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEK 616
Query: 409 KLFA-----NERCLQLSESENMKLRAKLDELK--LKYEP----EETVEVPVLKKRREVLP 457
LF+ NE+ L ESE L++K++ L+ LK + E V L+ RE L
Sbjct: 617 TLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLS 676
Query: 458 VDITTAKDACVNNSALGGEVYRLP----PQKEETQSCPNSLEDNNLQLEKS 504
V+I + +++ ++ E +L QK E + E N+ L+ S
Sbjct: 677 VEIRNLHNV-LDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTS 726
Score = 46.6 bits (109), Expect = 7e-05
Identities = 106/553 (19%), Positives = 216/553 (39%), Gaps = 77/553 (13%)
Query: 91 LEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRV 150
LE+ +E L Q++ EL+ +++KLK E + + L+ + QK+ + + E
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
Query: 151 MSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKE 210
+ Q M ES++ T ++ +ELQ ++ Q+ Q++ K+
Sbjct: 65 LKRENQRLMEI-----------CESLEKTKQKISHELQVKESQVNF----QEGQLNSGKK 109
Query: 211 EKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMER 270
+ E+ E+E + LE+++ A Q V +L+P + +F +
Sbjct: 110 QIEKLEQELKRCKSELERSQQAAQSADV--------SLNPCNTPQKIFT------TPLTP 155
Query: 271 QLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQT--EFEQQERLLAMLE---- 324
KY+ LK++ E+ +R++ ++ L K SQT + R +A +
Sbjct: 156 SQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSS 215
Query: 325 ----QKNGEIKHLLGEIRNL---EKFKNLYDSMESKPSVDSGTLE-----------DNTY 366
Q+ HL + F Y S E + + TL+ DN+
Sbjct: 216 VFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSS 275
Query: 367 YTDLLQMKLDNLNKEIESTKGELSI------QRMKALFESQRALDIER-----KLFANER 415
LL +L N+E+ + EL + + MK + L ++ +L E+
Sbjct: 276 SPHLLD-QLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEK 334
Query: 416 CLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDA-CVNNSALG 474
L E ++ A+ D+ KY T LKK E L A+ A C +
Sbjct: 335 VLNKCRDELVRTTAQYDQASTKY----TALEQKLKKLTEDLSCQRQNAESARCSLEQKIK 390
Query: 475 GEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVK 534
+ + Q +L+ +Q++ ++ L KN+ +Q + +K
Sbjct: 391 EKEKEFQEELSRQQRSFQTLDQECIQMKARLT-----QELQQAKNMHNVLQAELDKLTSV 445
Query: 535 LIGVPADAEALSERSGNTPNSPRLA--AESKLQTEVKEGKETSSKLEKETCKKLHPILYV 592
+ + E ++ + + + E++L+ ++E K+ ++ L+ + +K + ++
Sbjct: 446 KQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHL 505
Query: 593 SSKSTPETQCPQQ 605
++ QC Q
Sbjct: 506 EAELKNIKQCLNQ 518
Score = 40.8 bits (94), Expect = 0.004
Identities = 64/312 (20%), Positives = 132/312 (42%), Gaps = 43/312 (13%)
Query: 54 SYEQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRS---HGQEVNELK 110
S ++E T + ++ +E L CE +Q LEKLEE++ +E+ EL+
Sbjct: 1530 SLQEENLTRKETPSAPAKGVEELESLCEVYRQS----LEKLEEKMESQGIMKNKEIQELE 1585
Query: 111 TKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSE-ELRVMSERVQE---SMSSEMLAL 166
+ + ELD L ++ L Q++L S E E ++ +E+ Q S+ E+ L
Sbjct: 1586 QLLSSERQELD--CLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARL 1643
Query: 167 QIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNAL 226
Q++ ++ S + + +Q R E ++ + E E K V +
Sbjct: 1644 QLQGLDLSSRSLLGIDTEDAIQGRNESCDI-------SKEHTSETTERTPKHDV--HQIC 1694
Query: 227 EKARVANQDLQVQLDQALQQ-ALDP-------NSKGNSLFAEVEDRRAAMERQL--ISMK 276
+K A QDL + +++ + A+ P S + ED+ + +S
Sbjct: 1695 DKD--AQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFS 1752
Query: 277 VKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGE 336
+ + N+E + ++L++ + + RLL ++E ++ +++ LL E
Sbjct: 1753 GPNALVPMDFLGNQEDIHNLQLRV---------KETSNENLRLLHVIEDRDRKVESLLNE 1803
Query: 337 IRNLEKFKNLYD 348
++ L+ +L +
Sbjct: 1804 MKELDSKLHLQE 1815
Score = 38.9 bits (89), Expect = 0.014
Identities = 115/605 (19%), Positives = 240/605 (39%), Gaps = 82/605 (13%)
Query: 17 EEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESL 76
+EE L + + EL++ + R + + E E + +E++ ++L S
Sbjct: 1532 QEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSE 1591
Query: 77 SCECEAIKQQQKMHLEKLEEQLSRSHGQEVNEL---KTKIEKLKVELDEARLSEKQLKHQ 133
E + +++Q E+ +++L+ + ++L K + E+L +EL+ ARL QL+
Sbjct: 1592 RQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARL---QLQGL 1648
Query: 134 VDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQ 193
+ LL +E+ + +S E + E+ + T K +V+++ + Q
Sbjct: 1649 DLSSRSLLGIDTED-AIQGRNESCDISKEHTS--------ETTERTPKHDVHQICDKDAQ 1699
Query: 194 LEL-LITNLMRQVDRLK-------------------EEKEEREKEAVSYYNALEKARVAN 233
+L L + + +K E+K + E +S + +
Sbjct: 1700 QDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVP 1759
Query: 234 QDL---QVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNR 290
D Q + + + +++ L +EDR +E L MK L Q V
Sbjct: 1760 MDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEV--- 1816
Query: 291 EQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSM 350
++ +I +++ E+++ L+++N ++ LE F + +
Sbjct: 1817 ----QLMTKIEACIEL----------EKIVGELKKENSDLS------EKLEYFSCDHQEL 1856
Query: 351 ESKPSVDSGTLEDNTYYTDLLQMK--LDNLNKEIESTKGE-LSIQRMKALFESQRALDIE 407
+ G D + D + DN+ K +S K L ++ + S++A IE
Sbjct: 1857 LQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKA-SIE 1915
Query: 408 RKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDAC 467
+ E L++ ++E + L K +E K K E+ V+ R L ++ T
Sbjct: 1916 HEALYLEADLEVVQTEKLCLE-KDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKT 1974
Query: 468 VNNSALGGEVYRLPPQKEETQS-CPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDM-Q 525
L ++ + E QS C + ++ ++++ + + L D+ +
Sbjct: 1975 TALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELL---------QTLSSDVSE 2025
Query: 526 LKKEKKCV--KLIGVPADAEALSERSGNTPNS-PRLAAESKLQTEVKEGKETSSKLEKET 582
L K+K + KL + D++ALS N +L E +L VKE + ++L +
Sbjct: 2026 LLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELL--VKESESLQARLSESD 2083
Query: 583 CKKLH 587
+KL+
Sbjct: 2084 YEKLN 2088
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 90.9 bits (224), Expect = 3e-18
Identities = 128/621 (20%), Positives = 270/621 (43%), Gaps = 85/621 (13%)
Query: 13 LKEAEEERLKAAQYGLQLVESQN-ELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSR 71
LK+ +E R KA LQ +ES+ EL N+L + + E+ M + E+ K R
Sbjct: 1550 LKQFKEHR-KAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMK-----------R 1597
Query: 72 MLESLSCECEAIKQQQKMHLEKLEEQLSRSHG-------QEVNELKTKIEKLKVELDEAR 124
+ E+L E + +K+ K + K++E + + E E +IE LK + + +
Sbjct: 1598 VQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQK 1657
Query: 125 LSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEV 184
L+ + ++ + ++L EE+R +++ + S E + E + +K L+E +
Sbjct: 1658 LNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVE----ETLKVERDQLKENLRETI 1713
Query: 185 NELQYRQEQLELLITNLMRQ---VDRLKEEKEEREKEAVSYYNALEKARVA--NQDLQVQ 239
+QE+L+++ +L +D+L+ E+ E + LE + A QDL++Q
Sbjct: 1714 TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ 1773
Query: 240 LD-----QALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQ 294
+ L++ + K + +E D+ + M++ L + K Q ++ N Q+
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833
Query: 295 RMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKP 354
+K + +Q + + E+L ++ ++ + L EI NL + L++++E
Sbjct: 1834 TLKKDV------NETQKKVSEMEQLKKQIKDQSLTLSKL--EIENLNLAQKLHENLEEMK 1885
Query: 355 SVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKG-------ELSIQRMKALFESQRALDIE 407
SV ++ + L+++ D L + ++ TK EL RM + + +
Sbjct: 1886 SV-MKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLR 1944
Query: 408 RKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDAC 467
K+ +E+ +Q+S+ + ++K DEL+ K + + E+ +L+ + +V
Sbjct: 1945 EKI--SEKTIQISDIQKDLDKSK-DELQKKIQELQKKELQLLRVKEDV------NMSHKK 1995
Query: 468 VNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLK 527
+N E+ +L Q E S+ +N QL K + H++L +
Sbjct: 1996 IN------EMEQLKKQFEAQNLSMQSVRMDNFQLTKKL-----------HESLEEIRIVA 2038
Query: 528 KEKKCVKLIGVPADAE------ALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKE 581
KE+ ++ I E L E + ++ E +L + +G++ ++ +E
Sbjct: 2039 KERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRL---LSDGQQHLTESLRE 2095
Query: 582 TCKKLHPILYVSSKSTPETQC 602
C ++ +L S+ +C
Sbjct: 2096 KCSRIKELLKRYSEMDDHYEC 2116
Score = 72.0 bits (175), Expect = 1e-12
Identities = 132/623 (21%), Positives = 274/623 (43%), Gaps = 63/623 (10%)
Query: 2 EADIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYT 61
E+D+ +N L E E +L+ +N ++++L+ R + + YEQ + T
Sbjct: 468 ESDVFSNTLDTLSEIEWNP------ATKLLNQEN-IESELNSLRADYDNLVLDYEQLR-T 519
Query: 62 LQREVELKSRMLESLSCECEAIKQQQKMHLE-KLEEQLSRS---------HGQEV-NELK 110
+ E+ELK + L E EA++++ K E +L ++S + Q++ NEL
Sbjct: 520 EKEEMELKLKEKNDLD-EFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELS 578
Query: 111 TKIEKLKVELDEARLSEKQLKHQ-VDHQKELLSCKSEELRVMSERVQESMSSEMLALQI- 168
+K+E L+ + D+ + ++ + Q +++ K LS E + + Q +E +AL
Sbjct: 579 SKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAK 638
Query: 169 -ELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALE 227
E + S LKE++ EL +Q+E I Q++ K+ + + EKE S +N +
Sbjct: 639 RESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEIT 698
Query: 228 KARVANQDLQVQLDQALQQALDP--NSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQ 285
K + D +V D L+ L EVE+ A E ++ ++K + +
Sbjct: 699 KL-TSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVE 757
Query: 286 NVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRN------ 339
+ Q + +L I T + K ++ R+ +LE+ G+ K L ++
Sbjct: 758 RLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEE-IGKTKDDLATTQSNYKSTD 816
Query: 340 --LEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKAL 397
+ FK L+ E K + LE+N + + ++ NL+KE + L + +
Sbjct: 817 QEFQNFKTLHMDFEQKYKM---VLEEN----ERMNQEIVNLSKEAQKFDSSLGALKTELS 869
Query: 398 FESQRALDIERKLFANERCLQLSESENMKLRAKLDELKLK-YEPEETVEVPVLKKRREVL 456
+++Q + R++ ER L+E E +K + + + L+ E E+T+ L++ E +
Sbjct: 870 YKTQELQEKTREV--QER---LNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV 924
Query: 457 PVDITTAKDAC--------VNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIY 508
+T KD + L +++ +TQ + ++ Q +++++
Sbjct: 925 KT-LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL 983
Query: 509 TPVVSLSPHKNLPVDMQL--KKEKKCVKLIGV--PADAEALSER--SGNTPNSPRLAAES 562
+S +NL ++ K++ K++G+ D EA + + + + ++ + +
Sbjct: 984 KSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQR 1043
Query: 563 KLQTEVKEGKETSSKLEKETCKK 585
K+ + ++E E LE +K
Sbjct: 1044 KIFSLIQEKNELQQMLESVIAEK 1066
Score = 71.2 bits (173), Expect = 3e-12
Identities = 135/625 (21%), Positives = 276/625 (44%), Gaps = 91/625 (14%)
Query: 12 RLKEAEE--ERLKAAQYGLQLVESQNEL-QNQLDKCRNEMMTMTESYE-----QEKYTLQ 63
RL E E+ E+L+ LQ VE + L +L + E+ T+T+ + QE ++
Sbjct: 885 RLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIE 944
Query: 64 REVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEK-------L 116
R+ +LKS + ++++ + ++Q + LE L++ H + +N LK+KI + +
Sbjct: 945 RD-QLKSDIHDTVNMNIDT-QEQLRNALESLKQ-----HQETINTLKSKISEEVSRNLHM 997
Query: 117 KVELDEARLSEKQLKHQVDHQKELLSCKSEEL-------------RVMSERVQESMSSEM 163
+ E + +Q +D +++L + ++ L R + +QE +
Sbjct: 998 EENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQ 1057
Query: 164 LALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKE---EREKEAV 220
+ L+ + E E +KT LKE + QE+L LL L +Q + + +EK ++E E
Sbjct: 1058 M-LESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116
Query: 221 SYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQ 280
+ L + ++ QL + QQ L+ V++ + M++++ ++
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLN-----------VQEEMSEMQKKINEIENLKN 1165
Query: 281 SLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIK--HLLGEIR 338
LK + + E M+ +L++A L + + +ER + QK+ E + HL G IR
Sbjct: 1166 ELKNKEL-TLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIR 1224
Query: 339 NLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIEST----KGELSIQ-R 393
+E L E K + L+++ D L+ + +I +T K +Q
Sbjct: 1225 EIEA-TGLQTKEELK--IAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEE 1281
Query: 394 MKALFESQRALDIERKLFANERCLQ----LSESENMK-----LRAKLDELKLKYEPEET- 443
+ L E Q L +++ + + L+E K R +++ L+L + +E+
Sbjct: 1282 IPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQ 1341
Query: 444 VEVPVLKKRREVLPVDITTAKDAC-VNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLE 502
E+ L K R+ ++ T K+A V + L + + +E+Q S ++ +L ++
Sbjct: 1342 EEIKSLTKERD----NLKTIKEALEVKHDQLKEHIRETLAKIQESQ----SKQEQSLNMK 1393
Query: 503 KSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAES 562
+ + T +VS +M+ K K L+ + + LS+R + + + A+
Sbjct: 1394 EKDNETTKIVS---------EMEQFKPKDSA-LLRIEIEMLGLSKRLQESHDEMKSVAKE 1443
Query: 563 KLQTE-VKEGKETSSKLEKETCKKL 586
K + ++E ++ S KE K++
Sbjct: 1444 KDDLQRLQEVLQSESDQLKENIKEI 1468
Score = 66.6 bits (161), Expect = 6e-11
Identities = 117/591 (19%), Positives = 247/591 (41%), Gaps = 75/591 (12%)
Query: 17 EEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESL 76
E+E L + + E+ NEL+ ++ + T E E+ L + + ++SL
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL 1347
Query: 77 SCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLKHQVDH 136
+ +++ +L+ ++E L H Q LK I + ++ E++ ++Q + +
Sbjct: 1348 T--------KERDNLKTIKEALEVKHDQ----LKEHIRETLAKIQESQSKQEQSLNMKEK 1395
Query: 137 QKELLSCKSE-ELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLE 195
E SE E + + EML L L E ++ +E ++LQ QE L+
Sbjct: 1396 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQ 1455
Query: 196 LLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGN 255
L + + + E E+E + L++ +L+V L
Sbjct: 1456 SESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL--------------- 1500
Query: 256 SLFAEVEDRRAAMERQLISMKVKYQS-----LKKQNVFNREQMQRMKLQIATLLQMKGSQ 310
+E E + +++QL ++ K Q+ +K+ FN +Q+ ++ ++ L Q K +
Sbjct: 1501 ---SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHR 1557
Query: 311 TEFEQQERLLAMLEQKNGEIKHLLGE--------IRNLEKFKNLYDSMESKPSVDSGTLE 362
+ ++ L +E K E+ + L E I+ E+ K + ++++ ++ L+
Sbjct: 1558 ---KAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQ----IERDQLK 1610
Query: 363 DNTYYTDLLQMKLDNLNKEI---------ESTKGELSIQRMKALFESQRALDIERKLFAN 413
+NT +++ ++ KE E+ + I+ +K FE+Q+ L++E N
Sbjct: 1611 ENT--KEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQK-LNLENIETEN 1667
Query: 414 ERCLQLSESENMKLRAKLDELKLKYEPEETVEV---PVLKKRREVLPVDITTAKDACVNN 470
R Q+ ++R+ E EET++V + + RE + D+ ++ + +
Sbjct: 1668 IRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVH 1727
Query: 471 SALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPV-DMQLKKE 529
L + + N + + LE S + L + L + M LK++
Sbjct: 1728 MHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS-NDALKAQDLKIQEELRIAHMHLKEQ 1786
Query: 530 KKCV-KLIGVPAD-AEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKL 578
++ + KL G+ ++ + LS + NS +KLQ +++E K +L
Sbjct: 1787 QETIDKLRGIVSEKTDKLSNMQKDLENS-----NAKLQEKIQELKANEHQL 1832
Score = 63.2 bits (152), Expect = 7e-10
Identities = 100/511 (19%), Positives = 221/511 (43%), Gaps = 68/511 (13%)
Query: 4 DIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQ---NQLDKCRNEMMT---MTESYEQ 57
D + + +LKE ++ + Q L + E +E+Q N+++ +NE+ E E
Sbjct: 1120 DRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMET 1179
Query: 58 EKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLK 117
E+ L +++ ++S++ E + +K+ QK E + G + E++ + K
Sbjct: 1180 ERLELAQKLNENYEEVKSITKERKVLKELQK----SFETERDHLRGY-IREIEATGLQTK 1234
Query: 118 VELDEARLSEKQLKHQVDHQKELLSCKSEELRVMS--ERVQESMSSEMLALQIELTEMES 175
EL A + K+ + +D + +S K+ ++ E+ + E+ L E + +
Sbjct: 1235 EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPN 1294
Query: 176 MK--TTLKEEVNELQYRQEQLELLITNLMRQVD----RLKEEKEEREKEAVSYYNALEKA 229
+K + +E +NEL+ EQ + + +++ RL E+ +E ++E S +
Sbjct: 1295 VKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL 1354
Query: 230 RVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKK----Q 285
+ + L+V+ DQ + A++++ ++ E Q ++MK K K
Sbjct: 1355 KTIKEALEVKHDQLKEHI-------RETLAKIQESQSKQE-QSLNMKEKDNETTKIVSEM 1406
Query: 286 NVFNREQMQRMKLQIATL----------LQMKGSQTEFEQQERLLAMLEQKNGEIKHLLG 335
F + ++++I L +MK E + +RL +L+ ++ ++K +
Sbjct: 1407 EQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIK 1466
Query: 336 EI--RNLEKFKNLYDS-----------MESKPSVDSGTLEDNTYYTDL--LQMKLDNLNK 380
EI ++LE + L + E + ++ E +T L + KL N +
Sbjct: 1467 EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQ 1526
Query: 381 EIESTKGELSIQRMKALFESQRAL-DIERKLFANERCLQLSESENMKLRAKLDELKLKYE 439
EI + + +I+++ + E L + A + LQ ES+ ++L +L E
Sbjct: 1527 EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQ------E 1580
Query: 440 PEETVEVPV-----LKKRREVLPVDITTAKD 465
+E +++ + +K+ +E L ++ K+
Sbjct: 1581 SQEEIQIMIKEKEEMKRVQEALQIERDQLKE 1611
Score = 42.4 bits (98), Expect = 0.001
Identities = 117/615 (19%), Positives = 231/615 (37%), Gaps = 73/615 (11%)
Query: 30 LVESQNELQNQLDKCRNEMMTMTESYE---QEKYTLQREVELKSRMLESLSCECEAIKQQ 86
L ES E +++ + M + YE + L++E+E + + + ++
Sbjct: 2089 LTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANL-SLPYL 2147
Query: 87 QKMHLEKL---EEQLSRSHGQEVNELK---TKIEKLKVELDEA-RLSEKQLKHQVDHQKE 139
Q H+EKL ++ S + + +LK + + K+K E E+ E +V+ QKE
Sbjct: 2148 QTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKE 2207
Query: 140 LL----------SCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNE--- 186
LL S ELR + + E + +E S+KT ++ ++
Sbjct: 2208 LLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKE 2267
Query: 187 -LQYRQE------QLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQ 239
Q+ +E +E L + ++ DR+ + ++ N + + + +
Sbjct: 2268 MTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKE 2327
Query: 240 LDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNR-EQMQRMKL 298
+Q L+ + N K LF + + ++ + Q K +V +R Q+ K+
Sbjct: 2328 WEQDLKSLKEKNEK---LFKNYQTLKTSLASG-AQVNPTTQDNKNPHVTSRATQLTTEKI 2383
Query: 299 QIATLLQMKGSQTEFEQQERLLAM---LEQKNGEIKHLLGEIRN----LEKFKNLYDSME 351
+ + ++ ++ +++ M LE N I L ++ LEK K ++
Sbjct: 2384 RELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQ 2443
Query: 352 SKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLF 411
K ++ + ++ + +K+D L K + + E I KA E Q+ ++ R L
Sbjct: 2444 DKVALGAKPYKEEIEDLKMKLVKID-LEKMKNAKEFEKEISATKATVEYQK--EVIRLLR 2500
Query: 412 ANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNS 471
N R Q ++ ++ + +P+ + + + V T A +
Sbjct: 2501 ENLRRSQQAQDTSV--------ISEHTDPQPSNKPLTCGGGSGI--VQNTKALILKSEHI 2550
Query: 472 ALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKK 531
L E+ +L Q E+ N L NN L V + K + + K+
Sbjct: 2551 RLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTW---------KERTLKREAHKQVT 2601
Query: 532 CVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLE--KETCKKLHPI 589
C P S++ TP+ E LQ V + S + ++ HP+
Sbjct: 2602 CENSPKSPKVTGTASKKKQITPSQ---CKERNLQDPVPKESPKSCFFDSRSKSLPSPHPV 2658
Query: 590 LYVSSKS---TPETQ 601
Y + S PE Q
Sbjct: 2659 RYFDNSSLGLCPEVQ 2673
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 89.0 bits (219), Expect = 1e-17
Identities = 122/633 (19%), Positives = 275/633 (43%), Gaps = 63/633 (9%)
Query: 15 EAEEERLKAAQ-YGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRML 73
E E E K Y +++ +N+ + +++ + + +T E++ + +++ +R
Sbjct: 1343 EYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTREN 1402
Query: 74 ESLSCECEAIKQ---QQKMHLEKLEE--QLSRSHGQEVNELKTKIEKLKVELDEARLSEK 128
SLS E + +K Q +L ++EE Q ++ G EV++ K ++E ++ + R E
Sbjct: 1403 RSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEES 1462
Query: 129 -QLKHQVDHQKELLSCKSEELRVMSERVQES------MSSEMLALQIELTEMESMKTTLK 181
+ K +D + + K++E+ + + + + + E LQ +++ ++
Sbjct: 1463 VRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSAT 1522
Query: 182 EEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLD 241
E +N+L+ ++++L T L +R+ +E+ ++++ + N+L++ ++ Q ++ +L+
Sbjct: 1523 ETINKLKVQEQEL----TRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELN 1578
Query: 242 QALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIA 301
+ + A + + K L E+E R +++ Q I + Q L++ ++ + ++ Q
Sbjct: 1579 RLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD 1638
Query: 302 TL-LQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGT 360
L ++ Q E+ RL + +E + LL E ++++ + + S +
Sbjct: 1639 VLDGHLREKQRTQEELRRLSSEVEALR---RQLLQEQESVKQAHLRNEHFQKAIEDKSRS 1695
Query: 361 LEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMK----ALFESQRALDIERKLFANERC 416
L ++ + LQ +NL KE + EL R++ S+ D +
Sbjct: 1696 LNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQ 1755
Query: 417 LQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVD--ITTAKDACV----NN 470
LQ+S + ++L+ +++L+ E + + K +++ L I +K+ C
Sbjct: 1756 LQISNNRTLELQGLINDLQ---RERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQER 1812
Query: 471 SALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDM---QLK 527
+L ++ L K Q + L LE + + ++ Q
Sbjct: 1813 ESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYS 1872
Query: 528 KEKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVK------------EGKETS 575
++++ ++ I E+ E+S NS R E +LQ E+K +ET
Sbjct: 1873 RKEEAIRKI------ESEREKSEREKNSLRSEIE-RLQAEIKRIEERCRRKLEDSTRETQ 1925
Query: 576 SKLEKETCK------KLHPILYVSSKSTPETQC 602
S+LE E + KL Y S + T +T+C
Sbjct: 1926 SQLETERSRYQREIDKLRQRPYGSHRET-QTEC 1957
Score = 65.1 bits (157), Expect = 2e-10
Identities = 105/486 (21%), Positives = 219/486 (45%), Gaps = 61/486 (12%)
Query: 6 ITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQE---KYTL 62
+T LR + +ER Q + S ELQ Q K E+ + + ++ + L
Sbjct: 1535 LTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKL 1594
Query: 63 QREVELKSRMLESLSCECEAIKQQ-------QKMHLEKLEEQLSRSHG---------QEV 106
+ E+E R L+ + + + QQ +K + L +Q G +E+
Sbjct: 1595 EEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEEL 1654
Query: 107 NELKTKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEEL---RVMSERVQ---ESMS 160
L +++E L+ +L + + S KQ + +H ++ + KS L ++ ER+Q E+++
Sbjct: 1655 RRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLT 1714
Query: 161 SEMLALQIEL--------------TEMESMK-TTLKEEVNELQY---RQEQLELLITNLM 202
E L L+ EL +E +S K T+ E ++LQ R +L+ LI +L
Sbjct: 1715 KEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQ 1774
Query: 203 RQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQ-VQLDQALQQALDPNSKGNSLFAEV 261
R+ + L++E E+ +K+A+ N +++++ NQ Q VQ ++L + + + +
Sbjct: 1775 RERENLRQEIEKFQKQALEASNRIQESK--NQCTQVVQERESLLVKIKVLEQDKARLQRL 1832
Query: 262 EDR----RAAMERQL-ISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQ 316
ED ++ +E + + +++ + + QN N+ + Q + + A ++ ++E E+
Sbjct: 1833 EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEA----IRKIESEREKS 1888
Query: 317 ERLLAMLEQKNGEIKHLLGEIRNLEK--FKNLYDSMESKPSVDSGTLEDNTYYTDLLQMK 374
ER L EI+ L EI+ +E+ + L DS S D L+ +
Sbjct: 1889 EREKNSL---RSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1945
Query: 375 LDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDEL 434
++E + T+ E ++ K +F+ R +L+ + + + + +K + ++E+
Sbjct: 1946 PYGSHRETQ-TECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV 2004
Query: 435 KLKYEP 440
+ +P
Sbjct: 2005 ASEIQP 2010
Score = 57.8 bits (138), Expect = 3e-08
Identities = 96/481 (19%), Positives = 193/481 (40%), Gaps = 85/481 (17%)
Query: 14 KEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRML 73
KE E ERL+ + + E +N+L K RN Y +E L+ + E + +
Sbjct: 1167 KEYEIERLRVLLQ--EEGTRKREYENELAKVRNH-------YNEEMSNLRNKYETEINIT 1217
Query: 74 ESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLKHQ 133
++ E K+ +L ++LSR E +LK +I +L + +A ++ +
Sbjct: 1218 KTTIKEISMQKEDDSKNLRNQLDRLSR----ENRDLKDEIVRLNDSILQATEQRRRAEEN 1273
Query: 134 VDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQ 193
QK +C SE +M ++ L+IEL ++ ++ E+ + E+
Sbjct: 1274 ALQQK---ACGSE---IMQKKQH---------LEIELKQVMQQRS---EDNARHKQSLEE 1315
Query: 194 LELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSK 253
I + ++++RLK E +E K Y N L K R + + L + +
Sbjct: 1316 AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEI----- 1370
Query: 254 GNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIA-TLLQMKGSQTE 312
N + E + + +L ++N E+++R+K + T ++ + +
Sbjct: 1371 -NITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEED 1429
Query: 313 FEQQERLLAMLEQKNGEIKHLLGEI--------------------------RNLEKFKNL 346
+QQ+ + + Q+ +++ L ++ + +E+ K L
Sbjct: 1430 IQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQL 1489
Query: 347 YDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDI 406
D K + D LED +Q L N T +L +Q + ++ +D
Sbjct: 1490 ID----KETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQEL---TRLRIDY 1542
Query: 407 ERKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDA 466
ER + ER ++ + + + + L EL+L+ + E E+ LK+ T ++D+
Sbjct: 1543 ER--VSQERTVK--DQDITRFQNSLKELQLQKQKVEE-ELNRLKR---------TASEDS 1588
Query: 467 C 467
C
Sbjct: 1589 C 1589
Score = 51.6 bits (122), Expect = 2e-06
Identities = 100/522 (19%), Positives = 209/522 (40%), Gaps = 85/522 (16%)
Query: 139 ELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESM--KTTLKEEVNELQYRQEQLEL 196
ELL+ + R +SE ++ ++ +IE+ E E + E N+ ++ + L+
Sbjct: 1005 ELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ- 1063
Query: 197 LITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNS 256
+ + E + + + S +A + + + LD+ Q + N K
Sbjct: 1064 ----------KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR 1113
Query: 257 LFAEVED---RRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEF 313
L E+ED RR ++E + K Y L+K +E + KL+ ++ K + E
Sbjct: 1114 LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEK--EYEI 1171
Query: 314 EQQERLLAMLEQKNGEIKHLLGEIRN--LEKFKNLYDSMESKPSVDSGTLEDNTYYTD-- 369
E+ LL + E ++ L ++RN E+ NL + E++ ++ T+++ + +
Sbjct: 1172 ERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDD 1231
Query: 370 --LLQMKLDNLNKEIESTKGEL----------SIQRMKA-------------LFESQRAL 404
L+ +LD L++E K E+ + QR +A + + ++ L
Sbjct: 1232 SKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHL 1291
Query: 405 DIERKLFANER----------------CLQLSESENMKLRAKL-DELKLKYEPEETVEVP 447
+IE K +R +Q E +L+A+ +E K ++E E
Sbjct: 1292 EIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENE---- 1347
Query: 448 VLKKRREVLPVDITTAKDACVNN-SALGGEVYRLPPQKEETQSCPNSLEDN----NLQLE 502
L K R +I + K+ + +++L QKEE S + DN N L
Sbjct: 1348 -LSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLS 1406
Query: 503 KSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAES 562
+ + ++ + V+ ++++K A +S+R R +
Sbjct: 1407 EEIKRLKNTLTQTTENLRRVEEDIQQQK---------ATGSEVSQRKQQLEVELRQVTQM 1457
Query: 563 KLQTEV--KEGKETSSKLEKETCKKLHPILYVSSKSTPETQC 602
+ + V K+ + ++K ++ K++ + + K T + +C
Sbjct: 1458 RTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKC 1499
Score = 41.6 bits (96), Expect = 0.002
Identities = 48/275 (17%), Positives = 118/275 (42%), Gaps = 24/275 (8%)
Query: 76 LSCECEAIKQQQKMHLE---------KLEEQLSRSHG--QEVNELKTKIEKLKVELDEAR 124
++ EC +QQ+ ++ +E+ ++ G + + + +++K+K +L
Sbjct: 187 VTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADL---- 242
Query: 125 LSEKQLKHQVDHQKE-LLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEE 183
EK +Q++ + E LL E + + + ++ + I E E + ++
Sbjct: 243 -REKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDK 301
Query: 184 VNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQA 243
+ +QE + ++ L + L + K+E ++ ++ + A +K LQ Q
Sbjct: 302 NTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWI 361
Query: 244 LQ--QALDPNSKGNS----LFAEVEDRRAAMERQLISMKVKYQSLKKQNVFN-REQMQRM 296
LQ + +D + K N+ F E + A ++ S++ KY K + + EQ++ +
Sbjct: 362 LQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKEL 421
Query: 297 KLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIK 331
+ + +L+ K + + + L+ +N + +
Sbjct: 422 EKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYR 456
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 88.2 bits (217), Expect = 2e-17
Identities = 118/492 (23%), Positives = 217/492 (44%), Gaps = 80/492 (16%)
Query: 62 LQREVELKSRMLESLSC----ECEAIKQQQKMHLEKLEEQLSRSHGQEV----------- 106
L R+ EL +L SLS E ++ KQ+ +HL ++ + L + QEV
Sbjct: 18 LPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAG 77
Query: 107 -------NELKTKIEKLKVELDEARLSE-----KQLKHQVDHQKELLSCKSEELRVMSER 154
N+LKTK+ KL+ EL+ A+ S + L++++ ++ L K EL M +
Sbjct: 78 EEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKE 137
Query: 155 VQ-ESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKE--- 210
++ E +E LAL+ E E E+ K L+ E L+ + EQL I + +Q+D KE
Sbjct: 138 LEKEKKVNEQLALRNEEAENENSK--LRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLL 195
Query: 211 -----------EKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFA 259
+ ++ E + Y + ++ AN+ ++VQ +Q +++ L+ + +
Sbjct: 196 SRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQ-NQEMRKNLEESVQEMEKMT 254
Query: 260 EVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTE------F 313
+ +R A+ Q ++ LKK+N + Q+Q ++ LL+ K + +
Sbjct: 255 DEYNRMKAIVHQTDNV---IDQLKKENDHYQLQVQ----ELTDLLKSKNEEDDPIMVAVN 307
Query: 314 EQQERLLAMLEQKNGEIKHLLGEIRNL-EKFKNL-YDSMESKPSVDSGTLEDNTYYTDLL 371
+ E +L K+ EI + NL EK KN D+ +S +++ +L
Sbjct: 308 AKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKML 367
Query: 372 QMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKL 431
+++ KE+E K I+ D++ +L N+ LS+ +MK+++ L
Sbjct: 368 TEQVEQYTKEME--KNTCIIE------------DLKNELQRNKGASTLSQQTHMKIQSTL 413
Query: 432 DELKLK-YEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQKEETQSC 490
D LK K E E T E+ R + + +A VY L E ++C
Sbjct: 414 DILKEKTKEAERTAELAEADAREKDKEL-----VEALKRLKDYESGVYGLEDAVVEIKNC 468
Query: 491 PNSLEDNNLQLE 502
N ++ + ++E
Sbjct: 469 KNQIKIRDREIE 480
Score = 63.5 bits (153), Expect = 5e-10
Identities = 128/668 (19%), Positives = 272/668 (40%), Gaps = 110/668 (16%)
Query: 12 RLKEAEEERLKAAQYGLQLVESQNELQ-----NQLDKCRNEMMTMTES-----------Y 55
+ +E + E +K + L ++ + ELQ N+ + ++M + +
Sbjct: 1565 KAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLA 1624
Query: 56 EQEKYTLQREVELKSRM--LESLSCECEAIKQQQKMHLEKLEE---QLSRSHGQEVNELK 110
E E+ +++ L S + L+ +S + E ++ ++ +++ E QL +H EV ++K
Sbjct: 1625 EMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVK 1684
Query: 111 TKIEKLKVELDEARLSEKQLKHQVDHQKELLS-CKSEELRVMSERVQESMS---SEMLAL 166
++E LK LD+++ + LK ++ QKE S + +R + ER++ ++ + AL
Sbjct: 1685 AEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKAL 1744
Query: 167 QIELTEMESMKTTLKEEVNELQYRQEQLELLITNLM-RQVDRLKEEKEEREKEAVSYYNA 225
L E+ + T EE Q++ L + ++ R LK + E+ + + A
Sbjct: 1745 SRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEA 1804
Query: 226 LEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVE-------DRRAAMERQLISMKVK 278
L+ ++ L L+ + N + E E + + ++R ++ K
Sbjct: 1805 LKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGK 1864
Query: 279 YQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTE---------------FEQQERLLAML 323
+ KQ++ E++QR ++ L+ K + + +E+ ++ A +
Sbjct: 1865 PLTDNKQSLI--EELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKI 1922
Query: 324 EQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYT-----DLLQMKLDNL 378
E ++K GE+ L K N + +K + TL+ T +L ++
Sbjct: 1923 EGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALES 1982
Query: 379 NKEIES-TKGELSIQRMKALFESQRALD--------------IERKLFANERCL------ 417
KE+E K L ++ + +AL ++ KL A E+
Sbjct: 1983 EKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYS 2042
Query: 418 ----------------QLSESENMKLRAKLDELKLKYEPEETVEVPVLKKR-REVLPVDI 460
Q + EN+KL ++ ELK + E + ++P LK + R++ +
Sbjct: 2043 KPSISGIESDDHCQREQELQKENLKLSSENIELKFQLE-QANKDLPRLKNQVRDLKEMCE 2101
Query: 461 TTAKDACVNNSALG-----GEVYRLPPQKEET----QSCPNSLEDNNLQLEKSVSIYTPV 511
K+ LG G + P+ E+T + ++ N QL+K+ I
Sbjct: 2102 FLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGI---- 2157
Query: 512 VSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAES-KLQTEVKE 570
L+ K ++ + +K K ++ + + T + ++ AE+ +L+ E+K+
Sbjct: 2158 --LTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKK 2215
Query: 571 GKETSSKL 578
+ + KL
Sbjct: 2216 ETDAAEKL 2223
Score = 57.4 bits (137), Expect = 4e-08
Identities = 131/644 (20%), Positives = 264/644 (40%), Gaps = 103/644 (15%)
Query: 5 IITNLRCRLK----EAEEERLKAAQYGLQLVESQNE-LQNQLDKCRNEMMTMTESYEQEK 59
++ NLR +LK +A++ + A Q G+Q +SQ + L Q+++ EM T E K
Sbjct: 330 MLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLK 389
Query: 60 YTLQREV---ELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKL 116
LQR L + + + +K++ K E+ E ++ EL +++L
Sbjct: 390 NELQRNKGASTLSQQTHMKIQSTLDILKEKTK-EAERTAELAEADAREKDKELVEALKRL 448
Query: 117 K------VELDEARLSEKQLKHQV---DHQKELLSCKSEELRVM-------SERVQESMS 160
K L++A + K K+Q+ D + E+L+ + +L + +E ++E +
Sbjct: 449 KDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVG 508
Query: 161 SEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEK-------- 212
E + I+LTE + K + + QYR E LL ++++ L+EE+
Sbjct: 509 LEPKTM-IDLTEFRNSK-----HLKQQQYRAENQILL-----KEIESLEEERLDLKKKIR 557
Query: 213 ---EEREKEAVSY------YNALEKARVANQDLQVQLD-QALQQALDPNSKGNSLFAEVE 262
+ER K + + N E ++ + +LD +L+ + SK L E+
Sbjct: 558 QMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELI 617
Query: 263 DRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQ-------MKGSQTE--F 313
++ +ER ++ K+Q+ K+ V +Q++ +I ++ +KG +T
Sbjct: 618 EKERDLERSR-TVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLII 676
Query: 314 EQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYD-SMESKPSVDSGTLEDNTYYTDLLQ 372
ERL+ +E KN E ++D S+ K VD T + +L +
Sbjct: 677 PSLERLVNAIESKNAE---------------GIFDASLHLKAQVDQLTGRNEELRQELRE 721
Query: 373 MKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFAN--------ERCLQLSESEN 424
+ + +N + K L I ++ R + +F + S+N
Sbjct: 722 SRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQN 781
Query: 425 MKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQK 484
L L EL+ K + + +E + R+ + + +L + Y +
Sbjct: 782 EYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIR---------HQQSLLYKEYLSEKET 832
Query: 485 EETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKE--KKCVKLIGVPADA 542
+T+S ++++ +LE V + + + NL +Q+ + KK +
Sbjct: 833 WKTES--KTIKEEKRKLEDQVQ--QDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITV 888
Query: 543 EALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKETCKKL 586
++E+S + + E +L+ E ++ K +E E C+K+
Sbjct: 889 LQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKI 932
Score = 57.4 bits (137), Expect = 4e-08
Identities = 127/622 (20%), Positives = 252/622 (40%), Gaps = 106/622 (17%)
Query: 13 LKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRM 72
++ EEERL + Q+ + + + ++ E + +TE+ Q +R+++L S
Sbjct: 542 IESLEEERLDLKKKIRQMAQERGK-RSATSGLTTEDLNLTENISQGDRISERKLDLLS-- 598
Query: 73 LESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLKH 132
L+++S EA + + + E +E++ +++ +T I K + +L E KQL+
Sbjct: 599 LKNMS---EAQSKNEFLSRELIEKE------RDLERSRTVIAKFQNKLKELVEENKQLE- 648
Query: 133 QVDHQKELLSCKSEELRVMSERVQESM----SSEMLALQIELTEMESM---KTTLKEEVN 185
+ KE+L E + + E+ S E L IE E + LK +V+
Sbjct: 649 --EGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVD 706
Query: 186 ELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQ 245
+L R E+L ++E E KEA++Y L KA + L+ + Q
Sbjct: 707 QLTGRNEEL--------------RQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQ 752
Query: 246 QALDPNSKGNSLF---AEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIAT 302
S+G+++ ++ D A +I+ + +Y Q + N+E+
Sbjct: 753 ------SEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEK---------- 796
Query: 303 LLQMKGSQTEFEQQERLLAMLEQKNGEI-KHLLGEIR----NLEKFKNLYDSMESKPSVD 357
++K + E R A++ + + K L E + K +E + D
Sbjct: 797 --KLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQD 854
Query: 358 SGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRM--KALFESQRAL-DIERKLFANE 414
+ +++ + LQM D + K + ++++ ++ K+L L ++ER+L
Sbjct: 855 AIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQL---- 910
Query: 415 RCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALG 474
EN K + +L L E E ++ L++ +E+ I A V+NS
Sbjct: 911 ------RKENEKQKNEL----LSMEAEVCEKIGCLQRFKEMAIFKI-AALQKVVDNSVSL 959
Query: 475 GEV-------------YRLPPQKE----ETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPH 517
E+ YR QK+ + S LE N+ L++ V + ++
Sbjct: 960 SELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKE 1019
Query: 518 KNLPVDMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSK 577
K ++ ++E K + ++ + + NS ++ K+ + E KE + +
Sbjct: 1020 KLHTIEQAWEQETKL-------GNESSMDKAKKSITNSDIVSISKKI--TMLEMKELNER 1070
Query: 578 LEKETCKKLHPILYVSSKSTPE 599
E C+K++ L S K E
Sbjct: 1071 QRAEHCQKMYEHLRTSLKQMEE 1092
Score = 57.0 bits (136), Expect = 5e-08
Identities = 118/577 (20%), Positives = 238/577 (41%), Gaps = 76/577 (13%)
Query: 30 LVESQNELQNQLDKCR---NEMMTMTESYEQEKYTLQREVELKSRMLES--LSCECEAIK 84
L ++ N+L N+L K + N+++ E +QE L+R+++ + L+ L+ +++
Sbjct: 1815 LTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLI 1874
Query: 85 QQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSE-KQLKHQVDHQKELLSC 143
++ + ++KLE QL +EV+ K + K EL R E K+ + +++ + L
Sbjct: 1875 EELQRKVKKLENQLE-GKVEEVDLKPMKEKNAKEEL--IRWEEGKKWQAKIEGIRNKLKE 1931
Query: 144 KSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLM- 202
K E+ +++++ A + +LT +KTT L R + E + L
Sbjct: 1932 KEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKK 1991
Query: 203 RQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVE 262
R +D + R +A+ + +E + N+ LQ +L AL++ ++ + +E
Sbjct: 1992 RNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKL-HALEKQFSKDTYSKPSISGIE 2050
Query: 263 -DRRAAMERQLISMKVKYQSLKKQNVFNREQ----MQRMKLQIATLLQMKGSQTEFEQQE 317
D E++L +K S + F EQ + R+K Q+ L +M EF
Sbjct: 2051 SDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEM----CEF---- 2102
Query: 318 RLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDN 377
L+++ E++ LG +R + +E + +E K+
Sbjct: 2103 -----LKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVE-----------KVQR 2146
Query: 378 LNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELK-- 435
N++++ G L+ ++M + E EN KL+A+L++LK
Sbjct: 2147 ENEQLKKASGILTSEKMANI-----------------------EQENEKLKAELEKLKAH 2183
Query: 436 ------LKYEPEETVEVPVL---KKRREVLPVDITTAKDACVNNSALGGEVYRLPPQKEE 486
+ YE + ++ ++ R+ L + A+ + + L ++ Q EE
Sbjct: 2184 LGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEE 2243
Query: 487 TQSCPNSLEDNNLQLEKSVS-IYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEAL 545
T E QLE + S + +V ++ +++ KK + + +
Sbjct: 2244 TGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEA 2303
Query: 546 SERSGNTPN-SPRLAAESKLQTEVKEGKETSSKLEKE 581
+ER + L + K+ V EG ET L++E
Sbjct: 2304 TEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRE 2340
Score = 55.1 bits (131), Expect = 2e-07
Identities = 117/530 (22%), Positives = 214/530 (40%), Gaps = 113/530 (21%)
Query: 1 MEADIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKY 60
MEA++ + C + E K A LQ V + ++L+ + +T Y
Sbjct: 924 MEAEVCEKIGCLQRFKEMAIFKIA--ALQKVVDNSVSLSELELANKQYNELTAKYRD--- 978
Query: 61 TLQREVELKSRM--LESLSCECEAIKQQQKMHLEKLEEQLSRSH------------GQEV 106
LQ++ L R LE L CE ++K+Q + ++LE + H G E
Sbjct: 979 ILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNES 1038
Query: 107 NELKTK----------IEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSER-- 154
+ K K I K L+ L+E+Q + +H +++ L+ M ER
Sbjct: 1039 SMDKAKKSITNSDIVSISKKITMLEMKELNERQ---RAEHCQKMYEHLRTSLKQMEERNF 1095
Query: 155 VQESMSSEMLALQIELTEMESM-------------KTTLKEEVNELQYRQEQLELLITNL 201
E+ +E+ + ++ ++E M ++ + EL+ + +L++ ++ L
Sbjct: 1096 ELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKL 1155
Query: 202 -------MRQVDRLKEEKEEREKEAVSYYNAL--------EKARVA---NQDLQVQLDQA 243
RQV+ L +++ R+KE S L EK+ +A ++ +QL +A
Sbjct: 1156 REISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEA 1215
Query: 244 ----------------------LQQALDPNSKGNSLFAEVEDR-RAAMERQLI-SMKVKY 279
L+Q LD + +A +E R RA RQ I S++ ++
Sbjct: 1216 TALGKLESITSKLQKMEAYNLRLEQKLDEKEQA-LYYARLEGRNRAKHLRQTIQSLRRQF 1274
Query: 280 QS---LKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGE 336
L +Q F++ +Q ++ + +MK SQ E E +E K +K L
Sbjct: 1275 SGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELK---LKGLEEL 1331
Query: 337 IRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMK-----LDNLNKEIESTKGELS- 390
I L+ K + ++ L++ +L++ K L+N+ E E T L
Sbjct: 1332 ISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEE 1391
Query: 391 --IQRMKALFE-----SQRALDIERKLFANERCLQLSESENMKLRAKLDE 433
+Q+ K E QR +D+ER+L +R ++E + K +E
Sbjct: 1392 EIVQQNKFHEERQMAWDQREVDLERQLDIFDR----QQNEILNAAQKFEE 1437
Score = 51.2 bits (121), Expect = 3e-06
Identities = 67/324 (20%), Positives = 142/324 (43%), Gaps = 21/324 (6%)
Query: 5 IITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQR 64
I+T+ + E E E+LKA +L + + L +QL TE E L++
Sbjct: 2157 ILTSEKMANIEQENEKLKA-----ELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRK 2211
Query: 65 EVELKSRMLESLSC---ECEAIKQQQKMHLEKLEEQL--SRSHGQEVNELKTKIEKLKVE 119
E++ ++ E L E + ++ + LE+ ++L + S G ++ +K K V
Sbjct: 2212 ELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVV 2271
Query: 120 LDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQE-SMSSEMLALQIELT----EME 174
K+L+ + + + ++ + ++ +ER Q+ + +E L QI++ E
Sbjct: 2272 TRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGA 2331
Query: 175 SMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQ 234
+ LK E+ L+ QL+ L+ Q++ K++ A S ++ + +
Sbjct: 2332 ETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSG-----AESTIPDADQLKEKIK 2386
Query: 235 DLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQ 294
DL+ QL + + + L E+E+ + ++ +K Y+ K+N+ E+++
Sbjct: 2387 DLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVK 2446
Query: 295 RMKLQIAT-LLQMKGSQTEFEQQE 317
++ Q+ L + EFE +E
Sbjct: 2447 KLSEQLGVELTSPVAASEEFEDEE 2470
Score = 50.1 bits (118), Expect = 6e-06
Identities = 78/369 (21%), Positives = 161/369 (43%), Gaps = 40/369 (10%)
Query: 12 RLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYE---QEKYTLQRE--- 65
R +E ++E LK + ++L + L + +N++ + E E +EK +QR+
Sbjct: 2057 REQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGH 2116
Query: 66 VELKSRMLESLSCECEAIKQQQKMHLEKLE---EQLSRSHG----QEVNELKTKIEKLKV 118
V R +++ E E K +EK++ EQL ++ G +++ ++ + EKLK
Sbjct: 2117 VRGSGRSGKTIP-ELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKA 2175
Query: 119 ELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLA---LQIELTEME- 174
EL++ + L HQ+ E + +E++ +ER+++ + E A L+I +E
Sbjct: 2176 ELEKLKA---HLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEI 2232
Query: 175 ---SMKTTLKEEVNELQY---RQEQLE---------LLITNLMRQVDRLKEEKEEREKEA 219
M L+E LQ+ R QLE +++T + + E ++ ++
Sbjct: 2233 LNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQS 2292
Query: 220 VSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKY 279
++ L K + + ++ L+Q + K E + ++R+L +++
Sbjct: 2293 ITDLKQLVKEATEREQKVNKYNEDLEQQI----KILKHVPEGAETEQGLKRELQVLRLAN 2348
Query: 280 QSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRN 339
L K+ Q++ K Q + + E+ + L L+ + E +HL EI+
Sbjct: 2349 HQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
Query: 340 LEKFKNLYD 348
L+K +D
Sbjct: 2409 LKKELENFD 2417
Score = 48.9 bits (115), Expect = 1e-05
Identities = 117/550 (21%), Positives = 220/550 (40%), Gaps = 141/550 (25%)
Query: 5 IITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQ- 63
+I + +LKE EE + + +++++ E+Q D E + S E+ ++
Sbjct: 629 VIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIES 688
Query: 64 ----------------------REVELKSRMLESLSCECEAIKQQQKM--------HLEK 93
R EL+ + ES EAI Q++ HLEK
Sbjct: 689 KNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRK---EAINYSQQLAKANLKIDHLEK 745
Query: 94 LEEQLSRSHGQEV----------------NELKTKIEKLKVELDEARLSEKQLKHQVD-- 135
L +S G V + + ++ E L L E EK+LK+ D
Sbjct: 746 ETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSL 805
Query: 136 -----------HQ-----KELLSCKS----------EELRVMSERVQESM------SSEM 163
HQ KE LS K EE R + ++VQ+ ++ +
Sbjct: 806 EDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLL 865
Query: 164 LALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSY- 222
ALQ++ EM+ + ++ LQ ++ L T L+ +L++E E+++ E +S
Sbjct: 866 NALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSME 925
Query: 223 YNALEKARVAN--QDLQVQLDQALQQALD----------PNSKGNSLFAEVED------- 263
EK +++ + ALQ+ +D N + N L A+ D
Sbjct: 926 AEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNM 985
Query: 264 --RRAA----MERQLISMKVKYQSLKKQNVFNREQM--------QRMKL-QIATLLQMKG 308
+R + +E + IS+K + +S+ K+ +E++ Q KL +++ + K
Sbjct: 986 LVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKK 1045
Query: 309 SQT--EFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSME-SKPSVDSGTLEDNT 365
S T + + + MLE K L E + E + +Y+ + S ++ E T
Sbjct: 1046 SITNSDIVSISKKITMLEMKE------LNERQRAEHCQKMYEHLRTSLKQMEERNFELET 1099
Query: 366 YYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENM 425
+ +L ++ LD K + + EL+ KA+ ++ R +R L+L ++E M
Sbjct: 1100 KFAELTKINLD-AQKVEQMLRDELADSVSKAVSDADR-----------QRILELEKNE-M 1146
Query: 426 KLRAKLDELK 435
+L+ ++ +L+
Sbjct: 1147 ELKVEVSKLR 1156
Score = 47.4 bits (111), Expect = 4e-05
Identities = 104/539 (19%), Positives = 226/539 (41%), Gaps = 87/539 (16%)
Query: 13 LKEAEEERLKAAQYGLQLVESQNELQNQLDKCR---NEMMTMTESYEQEKYTLQREVELK 69
+ +A+ +R+ L+L +++ EL+ ++ K R + E ++ + +EVE
Sbjct: 1130 VSDADRQRI------LELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESL 1183
Query: 70 SRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHG----QEVNELKTKIEKLKVELDEARL 125
L + + K+H + QLS + + + K+E + L++ +L
Sbjct: 1184 RMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQ-KL 1242
Query: 126 SEKQL---------KHQVDHQKELL-SCKSEELRVMSERVQESMSSEMLALQIE-LTEME 174
EK+ +++ H ++ + S + + + QE S M+ LQ + L M+
Sbjct: 1243 DEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQ 1302
Query: 175 SMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQ 234
MK + +E N ++ + ++EL + L + LK+ K ++ ++++ +E+ R+
Sbjct: 1303 EMKNSQQEHRN-MENKTLEMELKLKGLEELISTLKDTK--GAQKVINWHMKIEELRLQ-- 1357
Query: 235 DLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQ 294
+++L++ L + + N++ +E E +++E +++ +QN F+ E+
Sbjct: 1358 --ELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIV----------QQNKFHEER-- 1403
Query: 295 RMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKP 354
QM Q E + ER L + +++ EI + +KF+ S+ P
Sbjct: 1404 ----------QMAWDQREVD-LERQLDIFDRQQNEI------LNAAQKFEEATGSIPD-P 1445
Query: 355 SVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANE 414
S+ + L++ L + + I I +A +S +E KL E
Sbjct: 1446 SLP---------LPNQLEIALRKIKENIR------IILETRATCKS-----LEEKLKEKE 1485
Query: 415 RCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLK-KRREVLPVDITTAKDACVNNSAL 473
L+L+E + ++EL+L+ E + + R+E+ P T K + + +
Sbjct: 1486 SALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLK---IAHQTI 1542
Query: 474 GGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHK-NLPVDMQLKKEKK 531
RL ++E + LE + + V + + + H+ L D L K K+
Sbjct: 1543 ANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQ 1601
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/244 (22%), Positives = 105/244 (43%), Gaps = 34/244 (13%)
Query: 13 LKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRM 72
L E +L+ LQ ES+ D + + +T YE + L+ ++ K++
Sbjct: 2233 LNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQS 2292
Query: 73 LESLS-CECEAIKQQQKMHL--EKLEEQLSR----SHGQEVNE-LKTKIEKLKVELDEAR 124
+ L EA +++QK++ E LE+Q+ G E + LK +++ L++ +
Sbjct: 2293 ITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLD 2352
Query: 125 LSEKQLKHQVDHQKELLSCKS---------------EELRVMSERVQESMSSEMLALQIE 169
+ +L HQ++ K+ +S E MS+ ++ + E+ L+ E
Sbjct: 2353 KEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKE 2412
Query: 170 LT--------EMESMKTTLKEEVNELQYRQEQLELLITNL---MRQVDRLKEEKEEREKE 218
L E+E +K KEEV + +E+++ L L + EE E+ E+
Sbjct: 2413 LENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEES 2472
Query: 219 AVSY 222
V++
Sbjct: 2473 PVNF 2476
Score = 37.7 bits (86), Expect = 0.031
Identities = 76/366 (20%), Positives = 149/366 (40%), Gaps = 52/366 (14%)
Query: 14 KEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESY----------EQEKYTLQ 63
K A+EE ++ + G + ++N+L + E+ T+T+ ++EK TLQ
Sbjct: 1903 KNAKEELIRWEE-GKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQ 1961
Query: 64 REVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEA 123
R+++ ++ Q + + LE + +E+ ELK + L+ ++
Sbjct: 1962 RKLKTTGMTVD------------QVLGIRALESE------KELEELKKRNLDLENDILYM 2003
Query: 124 RLSEKQLKHQVDHQKELLS-CKSEELRVMSERVQESMSSEMLALQIELT-----EMESMK 177
R + + V L + E+L + ++ + S+ IE E E K
Sbjct: 2004 RAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQK 2063
Query: 178 TTLK--EEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQD 235
LK E EL+++ EQ + L QV LKE E +K EKA V +
Sbjct: 2064 ENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKK---------EKAEVQRKL 2114
Query: 236 LQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQL-----ISMKVKYQSLKKQNVFNR 290
V+ + + K L +V ++ QL I K +++++N +
Sbjct: 2115 GHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLK 2174
Query: 291 EQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSM 350
+++++K + L M +++ + E+++A E+ E+K L KN + +
Sbjct: 2175 AELEKLKAHLGHQLSMH-YESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEIL 2233
Query: 351 ESKPSV 356
K +V
Sbjct: 2234 NEKMTV 2239
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 85.1 bits (209), Expect = 2e-16
Identities = 121/593 (20%), Positives = 249/593 (41%), Gaps = 79/593 (13%)
Query: 13 LKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQ------REV 66
LK+ E+ K Q E N+LQ QLD+ + T +++ + + T +++
Sbjct: 536 LKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQL 595
Query: 67 ELKSRMLESLSCECEAIKQQQKMHLEKLE-----EQLSRSHGQE-VNELKTKIEKLKVEL 120
E +R L+ +C E K + + L+ E+ R+HG E +N+L+ +I L+ +L
Sbjct: 596 ESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDL 655
Query: 121 DEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTL 180
++ L +V+ +K L + +L ++ M+ ++ +Q L + E+
Sbjct: 656 KNGKI----LLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKAT 711
Query: 181 KEEVNELQYRQEQLELLITNLMRQVD-RLKEEKEEREKEAVSYYNALEKARVANQDL--- 236
K + + E +E + M++++ +L EE+ ++K A ++ + + DL
Sbjct: 712 KARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQS 771
Query: 237 QVQLDQALQQ--ALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQ 294
Q ++++ L+Q L+ + + +L E E ++ + + + M+ + + K + +Q
Sbjct: 772 QQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQEN 831
Query: 295 RMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKP 354
+++ L+ + ++ E+Q+ +G++K L ++ + F LY + +
Sbjct: 832 NHLMEMKMNLEKQNAELRKERQD--------ADGQMKELQDQLEAEQYFSTLYKTQVREL 883
Query: 355 SVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANE 414
+ E+ T LQ K L E +S +L I KA E Q A I + +++
Sbjct: 884 KEE---CEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSE-QLARSIAEEQYSD- 938
Query: 415 RCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALG 474
E E + ++ E+ +++ E T + + E N L
Sbjct: 939 -----LEKEKIMKELEIKEMMARHKQELTEKDATIASLEE--------------TNRTLT 979
Query: 475 GEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVK 534
+V L +KEE N L+D QL + LK E+
Sbjct: 980 SDVANLANEKEELN---NKLKDVQEQLSR----------------------LKDEEISAA 1014
Query: 535 LIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKETCKKLH 587
I + + L+ER+ T +LA + VK G +T + +++ +KLH
Sbjct: 1015 AIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLH 1067
Score = 60.1 bits (144), Expect = 6e-09
Identities = 88/392 (22%), Positives = 166/392 (42%), Gaps = 86/392 (21%)
Query: 10 RCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQE---KYTLQREV 66
RC L + + LK +Q + NEL Q D ++ +T EQE + Q ++
Sbjct: 760 RCSLLDCD---LKQSQQKI------NELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDL 810
Query: 67 ELKSRMLESLSCECEAIKQQQ------KMHLEKLEEQLSRSHGQ---EVNEL-------- 109
+++++ + +L + +KQ+ KM+LEK +L + ++ EL
Sbjct: 811 KMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQ 870
Query: 110 ------KTKIEKLKVELDEARLSEKQL---KHQVDHQKELLSCK---------SEEL-RV 150
KT++ +LK E +E K+L K ++ +++ L+ + SE+L R
Sbjct: 871 YFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARS 930
Query: 151 MSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKE 210
++E + E + ++E+ EM + K+E+ E LE L V L
Sbjct: 931 IAEEQYSDLEKEKIMKELEIKEMMARH---KQELTEKDATIASLEETNRTLTSDVANLAN 987
Query: 211 EKEE-----------------REKEAVSYYNALEKARVANQDLQVQLDQALQQAL---DP 250
EKEE E A + EK + + L+ Q L + + +P
Sbjct: 988 EKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEP 1047
Query: 251 NSKGNSLFAEVEDRRAAMERQLISMKVK--YQSLKKQNVFNREQMQRMKLQIATLLQMKG 308
+GN + + RR E + + M++K + L +Q + ++++ M+ QIA +
Sbjct: 1048 VKRGN----DTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIA-----EE 1098
Query: 309 SQTEFEQQERLLAMLEQKNGEIKHLLGEIRNL 340
SQ E Q L+ K+ +I+ L +++ L
Sbjct: 1099 SQIRIELQ----MTLDSKDSDIEQLRSQLQAL 1126
Score = 44.7 bits (104), Expect = 3e-04
Identities = 61/280 (21%), Positives = 129/280 (46%), Gaps = 47/280 (16%)
Query: 7 TNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEM-MTMTESYEQEKYTLQRE 65
T + +++E +EE + + G +L + + ELQ++ D ++ +T+T++ ++ E
Sbjct: 874 TLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAE 933
Query: 66 VELKSRMLESLSCECEAIKQQQKMHLEKLE---------EQLSRSHGQEVNELKTKIEKL 116
+ E + E E IK+ H ++L E+ +R+ +V L + E+L
Sbjct: 934 EQYSDLEKEKIMKELE-IKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEEL 992
Query: 117 KVELDEARLSEKQLKHQVDHQKELLSCKSE-ELRVMSERVQESMSSEMLALQIELTEMES 175
+L + ++QL D + + K++ E ++++ER ++ + LA E+ +
Sbjct: 993 NNKLKDV---QEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLA------EIMN 1043
Query: 176 MKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALE--KARVAN 233
K +K N+ R+++ E ++ LK E+E+ ++ + Y L +A++A
Sbjct: 1044 RKEPVKRG-NDTDVRRKEKENRKLHM-----ELKSEREKLTQQMIKYQKELNEMQAQIAE 1097
Query: 234 Q-----DLQVQLD-------------QALQQALDPNSKGN 255
+ +LQ+ LD QAL LD +S G+
Sbjct: 1098 ESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGS 1137
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 84.7 bits (208), Expect = 2e-16
Identities = 122/592 (20%), Positives = 257/592 (43%), Gaps = 50/592 (8%)
Query: 18 EERLKAAQYGLQLVESQNE-LQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESL 76
E L+ ++ + L+E + E L ++ E + + +++ +TLQ +V +++ E L
Sbjct: 529 EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ-LQEKNHTLQEQV---TQLTEKL 584
Query: 77 SCECEAIKQQQKMHLEKLEEQLS--RSHGQEVNELKTKIEKLKVELDEARLSEKQLKHQV 134
+ E+ KQ Q+ ++++EQ + R+ V L+T + +L +L+E++ QL Q+
Sbjct: 585 KNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI 644
Query: 135 DHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQL 194
+ ELL +Q + + ALQ + E+ + T L + +LQ +QE
Sbjct: 645 KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHC 704
Query: 195 ELLITNLMRQVDR---LKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPN 251
L ++L ++ L+++ EE E + + + + + L Q Q D
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLE 764
Query: 252 SKGNSLFAEVEDRRAAMERQLISMKVK---YQSLKKQNVFNREQMQRMKLQIATLLQMKG 308
+ L ++E + + + ++ K +S+K++ E+ Q +K TL Q
Sbjct: 765 LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETK 824
Query: 309 SQTEFEQQERL---LAMLEQKNGEIKHLLGEIRNL-EKFKNLYDSME-SKPSVDSGTLED 363
Q E E R+ + L++ E + L+ E+ + +K + DS++ SK + +
Sbjct: 825 IQHE-ELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKG 883
Query: 364 NTYYTDL----------LQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFAN 413
DL LQ++++N KE + K L ++ + ++ +L
Sbjct: 884 KAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA 943
Query: 414 ERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSAL 473
+ L+ +E E +L+ ++ELK E ++ ++ L+ ++ + T ++ L
Sbjct: 944 QNTLKQNEKEEQQLQGNINELKQSSE-QKKKQIEALQGELKIAVLQKTELENKL--QQQL 1000
Query: 474 GGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCV 533
L +KE+ N+ E + ++ S + S + L LK ++ +
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES----ELLATRQDLKSVEEKL 1056
Query: 534 KLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKETCKK 585
L A + +S R+ ++ ++KL E+K K T LE+++ KK
Sbjct: 1057 SL----AQEDLISNRN-------QIGNQNKLIQELKTAKAT---LEQDSAKK 1094
Score = 80.1 bits (196), Expect = 5e-15
Identities = 119/611 (19%), Positives = 267/611 (43%), Gaps = 83/611 (13%)
Query: 6 ITNLRCRLKEAEEERL-----------KAAQYGLQL--VESQNELQNQLDKCRNEMMT-M 51
+ +L +L+EA+ E KAAQ ++ ++S+ + + L + + +T +
Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL 196
Query: 52 TESYEQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKT 111
TE +E +Q +LK+ +L+ E A+ +++ + ++ L + ++ +E +LK
Sbjct: 197 TEELNKEATVIQ---DLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD 253
Query: 112 KIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQE------SMSSEMLA 165
+ +KL+ + + + QL+ ++ + ++ +EL+ + V E +++ +L
Sbjct: 254 ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLK 313
Query: 166 LQIELTEME-----------SMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEE 214
+ + T++E +++ TL ++ + Q Q +L T+L R L E+ E
Sbjct: 314 KEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEA 373
Query: 215 REKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLIS 274
+K L + Q L+ + Q QQ + G L +E+ + +
Sbjct: 374 TQK----LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ 429
Query: 275 MKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLL 334
+ + LK+Q + E++ + Q+A LQ+K S+ E + +E++ + E++H
Sbjct: 430 LGEAHGRLKEQRQLSSEKLMDKEQQVAD-LQLKLSRLEEQLKEKV-----TNSTELQH-- 481
Query: 335 GEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRM 394
L+K K + ++ L+ +T KL ++E ++
Sbjct: 482 ----QLDKTKQQHQEQQA--------LQQST------TAKLREAQNDLEQVLRQIG---- 519
Query: 395 KALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRRE 454
+ Q+ ++E L ++ + L E E L A K++ ET + L+++
Sbjct: 520 ---DKDQKIQNLEALLQKSKENISLLEKEREDLYA-----KIQAGEGETAVLNQLQEKNH 571
Query: 455 VLPVDITTAKDACVNNSALGGEVY-RLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVS 513
L +T + N S + L Q +E ++ + +D L LE SV+ ++
Sbjct: 572 TLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN 631
Query: 514 LSPHKNLPVDMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKE 573
S K +D+Q+K + + + + A+A ++R+ + A++ LQ + +E +
Sbjct: 632 ESKEKVSQLDIQIKAKTELL----LSAEAAKTAQRADLQNHLD--TAQNALQDKQQELNK 685
Query: 574 TSSKLEKETCK 584
+++L++ T K
Sbjct: 686 ITTQLDQVTAK 696
Score = 79.3 bits (194), Expect = 9e-15
Identities = 136/628 (21%), Positives = 259/628 (41%), Gaps = 71/628 (11%)
Query: 3 ADIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTL 62
AD+ +L ++++ + + QL + +LQ++ + C +++ + + Y+++ +L
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHC-SQLESHLKEYKEKYLSL 721
Query: 63 QR---EVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVE 119
++ E+E + + LE+ S E +A K+Q L++ + QL+ EL ++E K
Sbjct: 722 EQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ-QRQLNTDLELRATELSKQLEMEKEI 780
Query: 120 LDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTE-MESMKT 178
+ RL ++ ++ K+ L+ + EE +++ + E++S E EL +++ T
Sbjct: 781 VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDF-ETLSQETKIQHEELNNRIQTTVT 839
Query: 179 TLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQV 238
L++ E + +L + L + D LK K E EKE A+ ++L+
Sbjct: 840 ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
Query: 239 QLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMK---VKYQSLKKQNVFNREQMQR 295
QL ++ L + + ++ ++ +L SM+ ++ Q+ KQN +Q+Q
Sbjct: 900 QLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQG 959
Query: 296 MKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIK----------HLLGEIRNL----- 340
++ + K Q E Q E +A+L++ E K L E +
Sbjct: 960 NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1019
Query: 341 ------EKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQM----------KLDNLNK---- 380
E FK L + S T +D + L + ++ N NK
Sbjct: 1020 NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE 1079
Query: 381 --------EIESTKGELSIQ-RMKALFESQRALDIERKLFANERCLQLSESENMKLRAKL 431
E +S K E +Q R KAL + Q+ ++ K NE+ KL A++
Sbjct: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKS---------KL-AEI 1129
Query: 432 DELKLKYEPEETVEVPVLKKRREVLPVDITTAKDA----CVNNSALGGEVYRLPPQKEET 487
+E+K + E E T LK + +IT KDA L G+ L E+
Sbjct: 1130 EEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQE 1189
Query: 488 QSCPNSLEDNNLQLEKSVS---IYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEA 544
+ L+D + E+ + I S K V M+ +E + + + A E
Sbjct: 1190 KRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNEN 1249
Query: 545 LSERSGNTPNSPRLAAESKLQTEVKEGK 572
L +S R +E + QT+ G+
Sbjct: 1250 LGTVKKEWQSSQRRVSELEKQTDDLRGE 1277
Score = 75.5 bits (184), Expect = 1e-13
Identities = 138/622 (22%), Positives = 268/622 (43%), Gaps = 85/622 (13%)
Query: 31 VESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECEAIKQQQKMH 90
+E L+ +L + + M MT E+E L+ E + L+S EA Q +
Sbjct: 220 IEDVAVLKKELVQVQTLMDNMTLERERESEKLKDEC----KKLQSQYASSEATISQLRSE 275
Query: 91 LEKLEEQLSRSHGQEVNELKTKIEKL------------KVELDEARLSEKQLKHQVD--- 135
L K ++++ + QE+ +LK+ + +L K E D +L EK + V
Sbjct: 276 LAKGPQEVA-VYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKN 334
Query: 136 -----HQKELLSCKSEELRVMSE-----RVQESMSSEMLA---LQIELTEMESMKTTLKE 182
HQK+L C+ + R+ + R+ +S + A L+ EL+E+E+ LK
Sbjct: 335 IQATLHQKDL-DCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKA 393
Query: 183 EVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQ 242
E +LQ ++E+ E L ++++L + E E++ + L++ R + + + +Q
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
Query: 243 ALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMK-LQIA 301
+ A+++ + + +E QL L+ Q ++Q Q + LQ +
Sbjct: 454 QV--------------ADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQS 499
Query: 302 TLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGE----IRNLEKFK-NLYDSM---ESK 353
T +++ +Q + EQ R + +QK ++ LL + I LEK + +LY + E +
Sbjct: 500 TTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE 559
Query: 354 PSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGEL-----SIQRMKALFESQRALDIER 408
+V + E N + + + L + ES K +Q KA + + +
Sbjct: 560 TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL 619
Query: 409 KLFANERCLQLSESE------NMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITT 462
+ NE QL+ES+ +++++AK EL L E +T + R L + T
Sbjct: 620 ETSVNELNSQLNESKEKVSQLDIQIKAK-TELLLSAEAAKTAQ-------RADLQNHLDT 671
Query: 463 AKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPV 522
A++A + E+ ++ Q ++ + +++ QLE + Y K +
Sbjct: 672 AQNALQDKQQ---ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEEL 728
Query: 523 DMQLKK---EKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLE 579
+ Q+KK + VK A + +R NT R A E Q E+++ +S++L+
Sbjct: 729 EGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELR-ATELSKQLEMEKEIVSSTRLD 787
Query: 580 KETCKKLHPILYVSSKSTPETQ 601
+ KK + + K T + +
Sbjct: 788 LQ--KKSEALESIKQKLTKQEE 807
Score = 73.9 bits (180), Expect = 4e-13
Identities = 117/564 (20%), Positives = 233/564 (41%), Gaps = 98/564 (17%)
Query: 15 EAEEERLKAAQYGLQLVESQNE-LQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRML 73
E R++ LQ V+ + E L +L ++++ +++S + K ++E + +
Sbjct: 828 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI 887
Query: 74 ESLSCECEAIKQQQKMHLEK-----------LEEQLSRSHGQE----------------- 105
L C+ +K Q ++ +E LE++ SH +
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 106 -------------VNEL-------KTKIEKLKVELDEARLS----EKQLKHQVDHQKELL 141
+NEL K +IE L+ EL A L E +L+ Q+ + L
Sbjct: 948 KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
Query: 142 SCKSEELRVMS---ERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQL---E 195
+ + E++ V+ E+ QE+ +E+ + + LK +L QE L
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Query: 196 LLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGN 255
I N + + LK K E+++ L++ A QD+Q + ++ ++ SK
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSK-- 1125
Query: 256 SLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMK-LQIATLLQMKGS----- 309
AE+E+ + E+++ + + +S K +++ ++ K L I L+++G
Sbjct: 1126 --LAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLK 1183
Query: 310 ---QTEFEQQERLLAMLEQKNGEIK--------HLLGEIRNLEKFKNLYDSMESKPSVDS 358
+ E Q+ L ++++ E+K L EI+ E ++ E+K ++
Sbjct: 1184 AAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQI 1243
Query: 359 GTLEDNTYYT----DLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANE 414
L +N Q ++ L K+ + +GE+++ ++A ++ + D R L E
Sbjct: 1244 TALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAV--LEATVQNNQ--DERRALL--E 1297
Query: 415 RCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITT------AKDACV 468
RCL+ E E KL+ K+ EL+ K + T V L + + L + T A+D V
Sbjct: 1298 RCLK-GEGEIEKLQTKVLELQRKLD-NTTAAVQELGRENQSLQIKHTQALNRKWAEDNEV 1355
Query: 469 NNSALGGEVYRLPPQKEETQSCPN 492
N G+ + + ++ + C N
Sbjct: 1356 QNCMACGKGFSVTVRRHHCRQCGN 1379
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 83.6 bits (205), Expect = 5e-16
Identities = 132/583 (22%), Positives = 260/583 (44%), Gaps = 81/583 (13%)
Query: 14 KEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRML 73
KE +E+ L+ + +L + L+ ++ EM + E Y+ E L+ VE ++ +
Sbjct: 746 KEEQEDLLRKRER--ELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV 803
Query: 74 ESLSCECEAIKQQQ---KMHLEKLEEQLSRSHGQE------VNELKTKIEKLKVELDEAR 124
E L+ +Q Q +M ++ L+E+ + G+ V +L+ +IE LK + +A+
Sbjct: 804 EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK 863
Query: 125 LSEKQLKHQVDHQKE-LLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEE 183
+ K+ + ++ +E L+ + EE +S R ++ +E+ A Q L++ + L E+
Sbjct: 864 ETLKKYEGEIRQLEEALVHARKEEKEAVSAR--RALENELEAAQGNLSQTTQEQKQLSEK 921
Query: 184 VNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQA 243
+ E ++EQL L + + L + E+ +KE + +E +R + +LQ QLD+
Sbjct: 922 LKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMA---DIVEASRTSTLELQNQLDEY 978
Query: 244 LQQALDPNSKGNSLFAEVEDRR--AAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIA 301
++ +RR A M+RQL K K +K + + M+L
Sbjct: 979 KEK----------------NRRELAEMQRQL---KEKTLEAEKSRLTAMKMQDEMRLMEE 1019
Query: 302 TLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKN-LYDSMESKPSVDSGT 360
L + +Q E + +LL EQ ++++ L +L+ ++ L ME K S
Sbjct: 1020 ELRDYQRAQDEALTKRQLL---EQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEME 1076
Query: 361 LEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRM--------KALFESQRALDIERKLFA 412
LE+ +DLL ++ +++E + EL +R K E Q D++ ++
Sbjct: 1077 LEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNK-DLKSRIIH 1135
Query: 413 NERCLQLS-ESENMKLRAKLDELKLKYEPEE--TVEVPVLKKRRE------VLPVD---- 459
E + S E +++ A++ EL+ + E EE + + +R E V+ VD
Sbjct: 1136 LEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHL 1195
Query: 460 -ITTAKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPH- 517
+T KD L + + Q EE + + LE + +L++ + + ++ H
Sbjct: 1196 SLTDQKD------QLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELE---EQMDMNEHL 1246
Query: 518 ----KNLPVDMQLKKEKKCVKLIGVPADAEALSERSGNTPNSP 556
++ D++LKK K++ D + LS G+ +P
Sbjct: 1247 QGQLNSMKKDLRLKKLPS--KVLDDMDDDDDLSTDGGSLYEAP 1287
Score = 78.2 bits (191), Expect = 2e-14
Identities = 89/399 (22%), Positives = 177/399 (44%), Gaps = 35/399 (8%)
Query: 13 LKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRM 72
+++ EE + A + + V ++ L+N+L+ + + T+ +Q L+ E E K +
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQ- 931
Query: 73 LESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLS------ 126
L L E E ++ HL K E+L + V +T +L+ +LDE +
Sbjct: 932 LRRLKNEME----NERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELA 987
Query: 127 --EKQLKHQ-VDHQKELLSC--KSEELRVMSE------RVQESMSSEMLALQIELTEME- 174
++QLK + ++ +K L+ +E+R+M E R Q+ ++ L+ L ++E
Sbjct: 988 EMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEY 1047
Query: 175 --SMKTTLKEE----VNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEK 228
K+ LK++ V +++ + QLE+ + D L E ++ N L +
Sbjct: 1048 ELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQ 1107
Query: 229 ARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVF 288
R A QDL+ +Q D S+ L R++ E ++ M+ + L+ +
Sbjct: 1108 ERAARQDLECDKISLERQNKDLKSRIIHLEGSY---RSSKEGLVVQMEARIAELEDR--L 1162
Query: 289 NREQMQRMKLQIAT-LLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLY 347
E+ R LQ++ L+ K + + + L++ +QK+ L R +E+ +
Sbjct: 1163 ESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEI 1222
Query: 348 DSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTK 386
D +ES LE+ + LQ +L+++ K++ K
Sbjct: 1223 DRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKK 1261
Score = 74.3 bits (181), Expect = 3e-13
Identities = 131/622 (21%), Positives = 268/622 (43%), Gaps = 104/622 (16%)
Query: 9 LRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVEL 68
LR L+E + +++ Q+ ++ +LQ+QL + +E+ + S ++EK L E+
Sbjct: 679 LRKNLEELFQVKMEREQHQTEI----RDLQDQLSEMHDELDSAKRSEDREKGALIEELLQ 734
Query: 69 KSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEK 128
+ L+ L K++Q+ L K E +L+ G LK ++ E+D
Sbjct: 735 AKQDLQDLL----IAKEEQEDLLRKRERELTALKG----ALKEEVSSHDQEMD------- 779
Query: 129 QLKHQVDHQKELLSCKSEELRVMSERVQESMSS-EMLALQIELTEMESMKT-----TLKE 182
+LK Q D EL+ + E V+E+ + E+LA + +E + T L+E
Sbjct: 780 KLKEQYD----------AELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQE 829
Query: 183 EVNELQYRQEQLELLITNLMRQVDRLKEEK------------------------EEREKE 218
E +LQ R E+LE + L RQ++ LK ++ + EKE
Sbjct: 830 ENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKE 889
Query: 219 AVSYYNALEKARVANQ-------DLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQ 271
AVS ALE A Q Q QL + L++ + + L E+E+ R + +
Sbjct: 890 AVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKT 949
Query: 272 LISMK---------VKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAM 322
+ ++ + +L+ QN + E ++ + ++A + + +T ++ RL AM
Sbjct: 950 IEKLQKEMADIVEASRTSTLELQNQLD-EYKEKNRRELAEMQRQLKEKTLEAEKSRLTAM 1008
Query: 323 LEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEI 382
Q E++ + E+R+ ++ D +K + TL+D Y + D+ ++ +
Sbjct: 1009 KMQ--DEMRLMEEELRD---YQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLV 1063
Query: 383 ESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRA-----KLDELKLK 437
+ + ++S M+ E + + ++ + ++ +E ++ RA + D++ L+
Sbjct: 1064 KQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLE 1123
Query: 438 YEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDN 497
+ ++ LK R L ++K+ V + + L + E + +L+ +
Sbjct: 1124 RQNKD------LKSRIIHLEGSYRSSKEGLV--VQMEARIAELEDRLESEERDRANLQLS 1175
Query: 498 NLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPR 557
N +LE+ V +V ++L + Q K++ ++L + E E +S
Sbjct: 1176 NRRLERKVK---ELVMQVDDEHLSLTDQ--KDQLSLRLKAMKRQVEEAEEEIDRLESS-- 1228
Query: 558 LAAESKLQTEVKEGKETSSKLE 579
+ KLQ E++E + + L+
Sbjct: 1229 ---KKKLQRELEEQMDMNEHLQ 1247
Score = 58.9 bits (141), Expect = 1e-08
Identities = 104/432 (24%), Positives = 187/432 (43%), Gaps = 68/432 (15%)
Query: 57 QEKYTLQREVELKSRML-----ESLSCECEAIKQQQKMHLEKLEEQLSRSHGQ------- 104
Q++ T Q E ++L E + +A K++ + EK++ SR+ G
Sbjct: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQA 602
Query: 105 -----EVNELKTKIEKLKVELDEA-RLSEKQLKHQ--VDHQKELLSCKSEELRVM-SERV 155
EV +L + KL +E+ E R + ++K+Q + ++E + EELR +E+V
Sbjct: 603 CNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKV 662
Query: 156 QESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEE---- 211
+E+ + LQ L E E EE+ +++ +EQ + I +L Q+ + +E
Sbjct: 663 EENST-----LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSA 717
Query: 212 --KEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAME 269
E+REK A+ +E+ A QDLQ L +Q ED E
Sbjct: 718 KRSEDREKGAL-----IEELLQAKQDLQDLLIAKEEQ---------------EDLLRKRE 757
Query: 270 RQLISMKVKYQSLKKQNVFNREQMQRMKLQI-ATLLQMKGSQTEFEQQERLLAM------ 322
R+L ++K +LK++ + ++M ++K Q A L ++ S E + +LA
Sbjct: 758 RELTALK---GALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSE 814
Query: 323 LEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEI 382
+Q E++ L + N EK + + +E + + +ED + K K+
Sbjct: 815 QDQAGTEMRVKLLQEEN-EKLQGRSEELERRVAQLQRQIED----LKGDEAKAKETLKKY 869
Query: 383 ESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPEE 442
E +L + A E + A+ R L Q + S+ + + +L E KLK E E+
Sbjct: 870 EGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSE-KLKEESEQ 928
Query: 443 TVEVPVLKKRRE 454
++ LK E
Sbjct: 929 KEQLRRLKNEME 940
Score = 33.1 bits (74), Expect = 0.76
Identities = 32/131 (24%), Positives = 59/131 (45%), Gaps = 14/131 (10%)
Query: 6 ITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQRE 65
I L RL+ E +R +L EL Q+D +E +++T+ +Q L
Sbjct: 1155 IAELEDRLESEERDRANLQLSNRRLERKVKELVMQVD---DEHLSLTDQKDQ----LSLR 1207
Query: 66 VELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNE-LKTKIEKLKVELDEAR 124
++ R +E E + ++ +K +LEEQ+ ++NE L+ ++ +K +L +
Sbjct: 1208 LKAMKRQVEEAEEEIDRLESSKKKLQRELEEQM------DMNEHLQGQLNSMKKDLRLKK 1261
Query: 125 LSEKQLKHQVD 135
L K L D
Sbjct: 1262 LPSKVLDDMDD 1272
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 83.2 bits (204), Expect = 6e-16
Identities = 131/579 (22%), Positives = 250/579 (43%), Gaps = 86/579 (14%)
Query: 13 LKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMT--------------MTESYEQE 58
LK+ E+ K +Q E ++LQ QL++ + + T M++S Q
Sbjct: 519 LKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQL 578
Query: 59 KYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQE-VNELKTKIEKLK 117
+ +L RE++ ++R+LE+ + + Q + LE E+ R H E + +L+ +I L+
Sbjct: 579 E-SLNRELQERNRILENSKSQTDKDYYQLQAILE--AERRDRGHDSEMIGDLQARITSLQ 635
Query: 118 VELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELT-EMESM 176
E+ K LKH ++ K E R ++ + E L+I+L +++S+
Sbjct: 636 EEV-------KHLKHNLE--------KVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSL 680
Query: 177 KTTLKEEVNELQYRQEQL--------ELLITNLMRQVDRLKEEKEEREKEAVSYYNALEK 228
+ L++EVNE + + +L E + +LKEE+E REK ++
Sbjct: 681 QQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQ 740
Query: 229 ARVANQDLQVQLDQALQ------QALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSL 282
+ + DL+ Q Q L+ + ++ K +L E E + R L+ ++K Q+
Sbjct: 741 CSMLDVDLK-QSQQKLEHLTGNKERMEDEVKNLTLQLEQESNK----RLLLQNELKTQAF 795
Query: 283 KKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEK 342
+ N+ E ++MK +I TLL+ K EFE + L G+++ L ++ +
Sbjct: 796 EADNLKGLE--KQMKQEINTLLEAK-RLLEFELAQ-LTKQYRGNEGQMRELQDQLEAEQY 851
Query: 343 FKNLY--------DSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIES---TKGELSI 391
F LY + +E K + +++ + L +LD + ES +G L
Sbjct: 852 FSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEE 911
Query: 392 QRMKALFESQRALDIERKLFANE---------------RCLQLSESENMKLRAKLDELKL 436
Q + ES++A R+ ++ + +++ EN +L K+ + +
Sbjct: 912 QYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEE 971
Query: 437 KYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSA--LGGEVYRLPPQKEETQSCPNSL 494
+Y+ E+ E+ LK E T K VN A + + +++ +K TQ
Sbjct: 972 EYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKE 1031
Query: 495 EDN-NLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKC 532
++N LQLE + + H+ DMQ + ++C
Sbjct: 1032 KENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEEC 1070
Score = 64.7 bits (156), Expect = 2e-10
Identities = 112/540 (20%), Positives = 229/540 (42%), Gaps = 77/540 (14%)
Query: 88 KMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEE 147
+ +L +R+ L+ ++K +L+E +E QLK +++ + + K +
Sbjct: 403 RRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLD- 461
Query: 148 LRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDR 207
++M E +E ++ L+ ++++E K L+ +NE Q + EQ N+ +V
Sbjct: 462 -KIMKELDEEG--NQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVST 518
Query: 208 LKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAA 267
LK++ E+ +K + + +++AN+ L QL + L++A D + +
Sbjct: 519 LKDQLEDLKKVS-------QNSQLANEKLS-QLQKQLEEANDLLRTESDTAVRLRKSHTE 570
Query: 268 MERQLISMKVKYQSLKKQNVF---NREQMQRMKLQIATLLQM----KGSQTEF--EQQER 318
M + + ++ + L+++N ++ Q + Q+ +L+ +G +E + Q R
Sbjct: 571 MSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQAR 630
Query: 319 LLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNL 378
+ ++ E E+KHL NLEK + + E++ ++ E N D L KL +L
Sbjct: 631 ITSLQE----EVKHLK---HNLEKVEG--ERKEAQDMLNHSEKEKNNLEID-LNYKLKSL 680
Query: 379 NKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELKLKY 438
+ +E E + + + + Q + E++++ + +LK +
Sbjct: 681 QQRLEQEVNEHKVTKARLTDKHQ----------------SIEEAKSVAMCEMEKKLKEER 724
Query: 439 EPEETVE--VPVLKKRREVLPVDITTAKDACV----NNSALGGEVYRLPPQKEETQSCPN 492
E E E V ++K+ +L VD+ ++ N + EV L Q E
Sbjct: 725 EAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLE------- 777
Query: 493 SLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCV---KLIGVPADAEALSERS 549
+++N +L + T K L + Q+K+E + K + A+ +
Sbjct: 778 --QESNKRLLLQNELKTQAFEADNLKGL--EKQMKQEINTLLEAKRLLEFELAQLTKQYR 833
Query: 550 GNTPN----SPRLAAE----SKLQTEVKEGKETSSKLEKETCKKLHPILYVSSKSTPETQ 601
GN +L AE + +T+VKE KE + +E KK+ + + K T TQ
Sbjct: 834 GNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQEL--QNEKETLATQ 891
Score = 61.2 bits (147), Expect = 3e-09
Identities = 128/649 (19%), Positives = 264/649 (40%), Gaps = 114/649 (17%)
Query: 46 NEMMTMTESYEQEKYTLQREVELKSRMLESLSCECEAIK--------------------- 84
N ++ ES ++ Y L+ ++ + ++ + + +C
Sbjct: 419 NADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLE 478
Query: 85 ------QQQKMHLE----------KLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEK 128
+++KM L+ + E + R+ EV+ LK ++E LK ++L+ +
Sbjct: 479 STVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANE 538
Query: 129 ---QLKHQVDHQKELLSCKSE-ELRVMSERVQESMS-SEMLALQIELTE----MESMKTT 179
QL+ Q++ +LL +S+ +R+ + S S S++ +L EL E +E+ K+
Sbjct: 539 KLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQ 598
Query: 180 LKEEVNELQYRQE--------------QLELLITNLMRQVDRLKEEKEEREKEAVSYYNA 225
++ +LQ E L+ IT+L +V LK E+ E E +
Sbjct: 599 TDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDM 658
Query: 226 LEKARVANQDLQVQLD---QALQQALDPNSKGNSLF-AEVEDRRAAMERQLISMKVKYQS 281
L + +L++ L+ ++LQQ L+ + + A + D+ ++E + +
Sbjct: 659 LNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEK 718
Query: 282 LKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQ--ERLLAMLEQKNGEIKHLLGEIRN 339
K+ RE+ + +QI M + QQ E L E+ E+K+L ++
Sbjct: 719 KLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQ 778
Query: 340 LEKFKNLYDSMESKPSVDSGTL---------EDNTYY--TDLLQMKLDNLNKEIESTKGE 388
+ L + + ++ L E NT LL+ +L L K+ +G+
Sbjct: 779 ESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQ 838
Query: 389 L--------SIQRMKALFESQ---RALDIERKLFANERCLQLSESENMKLRAKLDELKLK 437
+ + Q L+++Q +IE K N + +Q ++E L +LD + K
Sbjct: 839 MRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETK 898
Query: 438 YEPEETV---------------EVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPP 482
E E+ + + R+E+ D T ++ NS L ++ L
Sbjct: 899 AESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSR-LEEANSMLTKDIEILRR 957
Query: 483 QKEE-TQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKE--KKCVKLIGVP 539
+ EE T+ + E+ L+ E+ +S + + KN+ + LK + K +++
Sbjct: 958 ENEELTEKMKKAEEEYKLEKEEEIS----NLKAAFEKNINTERTLKTQAVNKLAEIMN-- 1011
Query: 540 ADAEALSERSGNTPNSPRLAAES-KLQTEVKEGKETSSKLEKETCKKLH 587
+ + NT + + E+ KLQ E+ + +E +++ + K+L+
Sbjct: 1012 RKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELN 1060
Score = 59.7 bits (143), Expect = 8e-09
Identities = 108/487 (22%), Positives = 216/487 (44%), Gaps = 63/487 (12%)
Query: 2 EADIITNLRCRLKEAEEERLKAAQYGLQLVESQN----ELQNQLDKCRN--------EMM 49
++++I +L+ R+ +EE +K ++ L+ VE + ++ N +K +N ++
Sbjct: 620 DSEMIGDLQARITSLQEE-VKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLK 678
Query: 50 TMTESYEQE----KYTLQREVELKSRMLESLS---CECEAIKQQQKMHLEKLEEQLSRSH 102
++ + EQE K T R + + E+ S CE E ++++ EK E ++ +
Sbjct: 679 SLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIE 738
Query: 103 GQ------EVNELKTKIEKLKVELDEARLSEKQLKHQVDHQ--KELL--------SCKSE 146
Q ++ + + K+E L + K L Q++ + K LL + +++
Sbjct: 739 KQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEAD 798
Query: 147 ELRVMSERVQESMSSEMLA---LQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMR 203
L+ + +++++ +++ + A L+ EL ++ + ++ ELQ + E + T
Sbjct: 799 NLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKT 858
Query: 204 QVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSL------ 257
QV LKEE EE+ +E + L+ + + L QLD A +A L
Sbjct: 859 QVKELKEEIEEKNRENLKKIQELQNEK---ETLATQLDLAETKAESEQLARGLLEEQYFE 915
Query: 258 FAEVEDRRAAMERQLISMKVKYQS-LKKQNVFNREQMQRMKLQIATLLQ-MKGSQTEF-- 313
+ + A+ RQ I+ K S L++ N + ++ ++ + L + MK ++ E+
Sbjct: 916 LTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKL 975
Query: 314 ---EQQERLLAMLEQK-NGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTD 369
E+ L A E+ N E + L + N D + ++ L
Sbjct: 976 EKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENR 1035
Query: 370 LLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLS--ESENMKL 427
LQ++ LN+E E ++ ++ K L + Q L +E NE +QL+ ES+ +L
Sbjct: 1036 KLQLE---LNQEREKF-NQMVVKHQKELNDMQAQL-VEECAHRNELQMQLASKESDIEQL 1090
Query: 428 RAKLDEL 434
RAKL +L
Sbjct: 1091 RAKLLDL 1097
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 83.2 bits (204), Expect = 6e-16
Identities = 115/521 (22%), Positives = 223/521 (42%), Gaps = 60/521 (11%)
Query: 13 LKEAEEERLKAAQYGLQLVESQNELQN----------QLDKCRNEMMTMTESYEQEKYTL 62
L E + ER + A+ + E + EL +L+ +++ TM E+ ++EK L
Sbjct: 368 LAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVEL 427
Query: 63 QREVELKSRMLESLS--CECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVEL 120
++E + R +E L E E+I + KLE + Q + KTK +KL+ EL
Sbjct: 428 LNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQREL 487
Query: 121 DEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTL 180
++ R++ K ++ ++ L+ + +E+ + R++ + + + M +L
Sbjct: 488 EDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDV----------DMSLSL 537
Query: 181 KEEVNELQYRQEQLELLITNLMRQVDRLKE----EKEEREKEAVSYYNALEKARVANQDL 236
+E++ L QE+LE+ T+ R++ LKE +E +KE + Y A EK N+ L
Sbjct: 538 LQEISSL---QEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESL 594
Query: 237 QVQLDQALQQALDPNSKGNS-LFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQR 295
+ +L+ A ++ D + S L + + AME +S + + + Q+++
Sbjct: 595 KSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEK 654
Query: 296 MKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPS 355
M+L ++ +Q + E+ M + +K + + +LE ++ D E +
Sbjct: 655 MRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHL 714
Query: 356 VD-SGTL------EDNTYYTDLLQMK-------LDNLNKEIESTKGEL------------ 389
V+ TL E ++LQ K +DN ++++T+ +L
Sbjct: 715 VEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSE 774
Query: 390 SIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEV--- 446
MK L + A + + K E+ + S++ ++ + ELKL E EV
Sbjct: 775 GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 834
Query: 447 -PVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQKEE 486
L+K ++L A + V+ E QKEE
Sbjct: 835 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEE 875
Score = 68.9 bits (167), Expect = 1e-11
Identities = 99/589 (16%), Positives = 243/589 (41%), Gaps = 57/589 (9%)
Query: 36 ELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLE 95
EL+ Q++K R + E+ + ++ E ++ +E+L + + ++++ LE +
Sbjct: 647 ELKTQIEKMRLDYQHEIENLQNQQ---DSERAAHAKEMEALRAKLMKVIKEKENSLEAIR 703
Query: 96 EQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLK---HQVDHQKELLSCKSEELRVMS 152
+L ++ Q + E++ + KL+ EA + K+L+ + + Q +++ + +L+
Sbjct: 704 SKLDKAEDQHLVEMEDTLNKLQ----EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATE 759
Query: 153 ERV----------------QESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLEL 196
E++ + + ++ A + ++ +E K + + + + EL
Sbjct: 760 EKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL 819
Query: 197 LITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNS 256
+TNL + + + KE EKE +A +Q + + + + + N
Sbjct: 820 KLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNM 879
Query: 257 LFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKG-SQTEFEQ 315
L +++E R L M+ K++ ++ + ++++ IA +++M G + ++ +
Sbjct: 880 LSSDLEKLR----ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTK 935
Query: 316 QERLLAMLEQKNGEIKHLLGEIRNLEKF--KNLYDSMESKPSVDSGTLEDNTYYTDLLQM 373
L + E+ E++ L + F K++ D + + L+
Sbjct: 936 MNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELER 995
Query: 374 KLDNLNKEIESTKGELSIQRMKALFE----------SQRALDIERKLFANERCLQLSESE 423
KL +L K++E++ + Q +KA +E + ++++ L E L+ + E
Sbjct: 996 KLSDLEKKMETSHNQ--CQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREE 1053
Query: 424 NMKLRAKLDELKL---KYEPEETVE--VPVLKKRREVLPVDITTAKDACVNNSALGGEVY 478
N L +L+EL+ K + +T E + ++++ + + + +D N+ L E+
Sbjct: 1054 NSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELD 1113
Query: 479 RLPPQK----EETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVK 534
L EE L N ++E+ + + K+ + ++ K +
Sbjct: 1114 TLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAE 1173
Query: 535 LIGVPAD---AEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEK 580
+G D + E + N+ L + + +K+ E + L+K
Sbjct: 1174 ELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK 1222
Score = 68.6 bits (166), Expect = 2e-11
Identities = 89/425 (20%), Positives = 182/425 (42%), Gaps = 50/425 (11%)
Query: 9 LRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVEL 68
LR + ++ EE +LK + Q +++ K + +E+EK L+R++
Sbjct: 940 LRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD 999
Query: 69 KSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARL-SE 127
+ +E+ +C+ +K + + + +E KTK E++ L + L +E
Sbjct: 1000 LEKKMETSHNQCQELKAR---------------YERATSETKTKHEEILQNLQKTLLDTE 1044
Query: 128 KQLKHQVDHQKELLSCKSEELRVMSERVQESMSSE-MLALQIELTEMESMKTTLKEEVNE 186
+LK + LL + EELR +++ + + ++E + + ++T+ ++ E+ +
Sbjct: 1045 DKLKGAREENSGLLQ-ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQ 1103
Query: 187 LQYR-QEQLELLITNLMRQVDRLKEEKE------EREKEAVSYYNALEKARV-------A 232
+ Q +L+ L N ++ V+ L + KE ++ +E L++A A
Sbjct: 1104 TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSA 1163
Query: 233 NQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQ 292
Q+ V+L + L ++ D + L E+ R+ + QL+ MK + K +
Sbjct: 1164 LQEENVKLAEELGRSRDEVTSHQKL----EEERSVLNNQLLEMKKRESKFIKDADEEKAS 1219
Query: 293 MQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLE--------KFK 344
+Q+ + LL K E E+ + +L +N K L ++ LE K K
Sbjct: 1220 LQKSISITSALLTEK--DAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVK 1277
Query: 345 NL-YDSMESKPSVDSGTLEDNTYYTD---LLQMKLDNLNKEIESTKGELSIQRMKALFES 400
NL E+K + S + +T + + ++D LN I + + +MK S
Sbjct: 1278 NLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMS 1337
Query: 401 QRALD 405
+ AL+
Sbjct: 1338 EAALN 1342
Score = 52.4 bits (124), Expect = 1e-06
Identities = 73/329 (22%), Positives = 143/329 (43%), Gaps = 38/329 (11%)
Query: 4 DIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCR-----NEMMTMTESYEQE 58
+I+ NL+ L + E++ A + L++ EL+ Q DK + + M + E +E
Sbjct: 1031 EILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKE 1090
Query: 59 KYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKL--EEQLSRSHGQEVNELKTKIEKL 116
K +E + L E + +K+ ++E+L ++L Q++ E + +IE L
Sbjct: 1091 KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETL 1150
Query: 117 KVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERV--QESMSSEMLALQIELTEME 174
K A +QL + +L +EEL + V + + E L +L EM+
Sbjct: 1151 K---QAAAQKSQQLSALQEENVKL----AEELGRSRDEVTSHQKLEEERSVLNNQLLEMK 1203
Query: 175 SMKTTLKEEVNE----LQYRQEQLELLITNLMRQVDRLKEE------KEEREKEAVSYYN 224
++ ++ +E LQ L+T ++++L+ E + K S
Sbjct: 1204 KRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQ 1263
Query: 225 ALE----KARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQ 280
LE K + ++L++QL + +Q +S GN+ ED R A E Q+ +
Sbjct: 1264 TLESDKVKLELKVKNLELQLKENKRQL--SSSSGNTDTQADEDER-AQESQIDFLNSVIV 1320
Query: 281 SLKKQNVFNREQMQRMKLQIATLLQMKGS 309
L+++N Q +MK+++ + + G+
Sbjct: 1321 DLQRKN-----QDLKMKVEMMSEAALNGN 1344
Score = 41.6 bits (96), Expect = 0.002
Identities = 67/317 (21%), Positives = 128/317 (40%), Gaps = 56/317 (17%)
Query: 162 EMLALQIELTEMESMKTT--LKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEA 219
E L + +L E K T + E EL ++ + + L ++D+L+ E ++E
Sbjct: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
Query: 220 VSYYNALEKARVANQDLQVQLDQAL---------------------QQALDPNSKGNSLF 258
V N LE+ + +DLQ ++++ Q L +K + L
Sbjct: 425 VELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQ 484
Query: 259 AEVEDRRAA--MERQLISMKVKYQSLKKQNVFN-REQMQRMK-----------LQIATLL 304
E+ED R A E+ I K +L+ Q V R +++ K LQ + L
Sbjct: 485 RELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSL 544
Query: 305 QMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDN 364
Q K T + Q + ++ E E + ++ K LY + E +
Sbjct: 545 QEKLEVTRTDHQREITSLKEHFGAR------EETHQKEIKALYTATEKLSKEN------- 591
Query: 365 TYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESEN 424
+ L+ KL++ NKE + A+ Q+A++ + F+ + L +E
Sbjct: 592 ----ESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFS--KGLGTETAEF 645
Query: 425 MKLRAKLDELKLKYEPE 441
+L+ ++++++L Y+ E
Sbjct: 646 AELKTQIEKMRLDYQHE 662
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 83.2 bits (204), Expect = 6e-16
Identities = 135/667 (20%), Positives = 273/667 (40%), Gaps = 108/667 (16%)
Query: 14 KEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYE----------QEKYTLQ 63
K+ E+R+ A+ QL E + + +N L K RN+ M E QE +
Sbjct: 1001 KKLMEDRI--AECSSQLAEEEEKAKN-LAKIRNKQEVMISDLEERLKKEEKTRQELEKAK 1057
Query: 64 REVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKV----- 118
R+++ ++ L+ E +A + K+ L K EE+L + + +E K LKV
Sbjct: 1058 RKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ 1117
Query: 119 ----ELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEME 174
EL E SEK +++ + QK LS + E L+ E ++ +++ E+
Sbjct: 1118 AQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177
Query: 175 SMKTTLKEEVN----ELQYRQEQLELLITNLMRQVDRLKEEKEEREK----------EAV 220
+K L+EE ++Q +++ + L Q+++ K K EK E
Sbjct: 1178 ELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELA 1237
Query: 221 SYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQ 280
L++ + ++ + +LD +Q+ S+G+ L E+ ++ + ++ +L ++ +
Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE 1297
Query: 281 SLKK-------------------QNVFNREQMQRMKL--QIATLLQMKGSQTEFEQQE-- 317
+K Q + E Q++ L +I L + K S E +++E
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357
Query: 318 -------RLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDL 370
++LA+ Q K + ++ +E + + S LE+ D
Sbjct: 1358 ARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK 1417
Query: 371 LQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAK 430
L+ + L +E++ +L QR Q A ++E+K ++ L +S + + +
Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQR-------QVASNLEKKQKKFDQLLAEEKSISARYAEE 1470
Query: 431 LDELKLKYEPEETVEVPVLKKRREVLPV----------------DITTAKDACVNN---- 470
D + + +ET + + + E L D+ ++KD N
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530
Query: 471 ----SALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQL 526
AL +V + Q EE + + ED L+LE ++ + ++L +
Sbjct: 1531 EKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ----AMKAQFERDLQTRDEQ 1586
Query: 527 KKEKKCVKLIGV-PADAEALSERSGNTPNSPRLAAESKLQTEVKEGK---ETSSKLEKET 582
+EKK + + V +AE ER + +A++ K++ ++K+ + E ++K E
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERK---QRALAVASKKKMEIDLKDLEAQIEAANKARDEV 1643
Query: 583 CKKLHPI 589
K+L +
Sbjct: 1644 IKQLRKL 1650
Score = 77.8 bits (190), Expect = 3e-14
Identities = 99/449 (22%), Positives = 200/449 (44%), Gaps = 59/449 (13%)
Query: 13 LKEAEEERLKAAQYGLQLVESQNELQNQLDKCRN----EMMTMTESYEQEKYTLQREVEL 68
L+EA+++ LK A+ Q +E + ++L+K +N E+ +T + ++ +E
Sbjct: 1390 LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASN-LEK 1448
Query: 69 KSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEK 128
K + + L E ++I + ++ E + + ++ + E L+ + +E K
Sbjct: 1449 KQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAK-EEFERQNK 1507
Query: 129 QLK-----------------HQVDHQKELLSCKSEELRVMSERVQESM-SSEMLALQIEL 170
QL+ H+++ K L + EE+R E +++ + ++E L++E+
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 171 TEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKAR 230
M++MK + + LQ R EQ E L++QV L+ E E+ K+ + +K
Sbjct: 1568 N-MQAMKAQFERD---LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKME 1623
Query: 231 VANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNR 290
+ +DL+ Q++ A + + + L A+++D +R+L + + Q ++
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKD----YQRELEEARASRDEIFAQ---SK 1676
Query: 291 EQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKN-LYDS 349
E +++K A +LQ+ Q E ER EQ+ E L EI N K+ L D
Sbjct: 1677 ESEKKLKSLEAEILQL---QEELASSERARRHAEQERDE---LADEITNSASGKSALLDE 1730
Query: 350 ---MESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDI 406
+E++ + LE+ +LL + ++++ EL+ +R A
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ--------- 1781
Query: 407 ERKLFANERCLQLSESENMKLRAKLDELK 435
++ Q E +N +L+AKL EL+
Sbjct: 1782 -----KSDNARQQLERQNKELKAKLQELE 1805
Score = 75.1 bits (183), Expect = 2e-13
Identities = 138/648 (21%), Positives = 268/648 (41%), Gaps = 112/648 (17%)
Query: 17 EEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESL 76
EE+ + A Q ++++ EL + ++ R + + E+ + L+ VE + + L
Sbjct: 887 EEKNILAEQ-----LQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQIL 941
Query: 77 SCECEAIKQQQKMHLEKLEEQLSRSHGQ------EVNELKTKIEKLKVE----------- 119
E K++ + H++ LEEQL G E + KI+K++ E
Sbjct: 942 QNE----KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKF 997
Query: 120 -----LDEARLSE--KQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTE 172
L E R++E QL + + K L ++++ VM ++E + E Q E
Sbjct: 998 IKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQ-EVMISDLEERLKKEEKTRQ----E 1052
Query: 173 MESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKE----EREKEAVSYYNALEK 228
+E K L E +LQ + +L+ I L Q+ + +EE + + E + NAL+
Sbjct: 1053 LEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKV 1112
Query: 229 ARVANQDLQVQL--------------DQALQQALDPNSKGNSLFAEVEDR---------- 264
R +LQ Q+ ++A +Q D + + +L E+ED
Sbjct: 1113 VR----ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQEL 1168
Query: 265 RAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLE 324
R E+++ +K ++L+++ + Q+Q M+ + AT L+ Q EQ +R A LE
Sbjct: 1169 RTKREQEVAELK---KALEEETKNHEAQIQDMRQRHATALEELSEQ--LEQAKRFKANLE 1223
Query: 325 Q-KNG---EIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKL----D 376
+ K G + K L E++ L++ K + K L D L+++L
Sbjct: 1224 KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283
Query: 377 NLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELK- 435
L E+++ L K + ++ A +E +L + LQ + + L +++ +L+
Sbjct: 1284 KLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEE 1343
Query: 436 ----LKYEPEETVEV------------PVLKKRREVLPVDITTAKDACVNNSALGGEVYR 479
L+ + EE E L ++ + D+ T + L +
Sbjct: 1344 EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA 1403
Query: 480 LPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVP 539
L + EE + LE +L++ + T V L + + +++ KK+KK +L+
Sbjct: 1404 LSQRLEEKALAYDKLEKTKNRLQQELDDLT--VDLDHQRQVASNLE-KKQKKFDQLL--- 1457
Query: 540 ADAEALSERSGNTPNSPRLAAESK------LQTEVKEGKETSSKLEKE 581
A+ +++S R + A K L ++E E + E++
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQ 1505
Score = 62.0 bits (149), Expect = 2e-09
Identities = 77/349 (22%), Positives = 150/349 (42%), Gaps = 57/349 (16%)
Query: 6 ITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQRE 65
+ +R +L+E E+E L+L + ++ Q ++ ++ T E E++K L ++
Sbjct: 1541 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER---DLQTRDEQNEEKKRLLIKQ 1597
Query: 66 V-ELKSRMLESLSCECEAIKQQQKMH--LEKLEEQLSRSHG------QEVNELKTKIEKL 116
V EL++ + + A+ ++KM L+ LE Q+ ++ +++ +L+ +++
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY 1657
Query: 117 KVELDEARLSEKQLKHQV-DHQKELLSCKSEELRVM-----SERVQESMSSEMLALQIEL 170
+ EL+EAR S ++ Q + +K+L S ++E L++ SER + E L E+
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEI 1717
Query: 171 TEMESMKTTLKEEVNELQYRQEQLEL----------LITNLMR----QVDRLKEEKEERE 216
T S K+ L +E L+ R QLE L+ + R QVD L E
Sbjct: 1718 TNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777
Query: 217 KEAVSYYNALEKARVANQDLQV-------------------------QLDQALQQALDPN 251
A NA ++ N++L+ QL++ L+Q
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKER 1837
Query: 252 SKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQI 300
+ N L E + + Q+ + K+Q +M+++K Q+
Sbjct: 1838 AAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQL 1886
Score = 59.3 bits (142), Expect = 1e-08
Identities = 49/261 (18%), Positives = 118/261 (45%), Gaps = 9/261 (3%)
Query: 14 KEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRML 73
+E EE R + Q ES+ +L++ + + S ++ Q EL +
Sbjct: 1659 RELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIT 1718
Query: 74 ESLSCECEAIKQQQKMH--LEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARL---SEK 128
S S + + +++++ + +LEE+L + L + K +++D +E+
Sbjct: 1719 NSASGKSALLDEKRRLEARIAQLEEELEEEQSN-MELLNDRFRKTTLQVDTLNAELAAER 1777
Query: 129 QLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQ 188
+ D+ ++ L +++EL+ + ++ ++ S+ A ++ +E+ L+E++ +
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKAT---ISALEAKIGQLEEQLEQEA 1834
Query: 189 YRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQAL 248
+ L+ +++ + + E+ + A Y +EKA + L+ QL++A ++A
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEAT 1894
Query: 249 DPNSKGNSLFAEVEDRRAAME 269
N+ L E++D A E
Sbjct: 1895 RANASRRKLQRELDDATEANE 1915
Score = 55.5 bits (132), Expect = 1e-07
Identities = 90/442 (20%), Positives = 169/442 (38%), Gaps = 70/442 (15%)
Query: 133 QVDHQKELLSCKSEELRVMSERV---------QESMSSEMLALQIELTEMESMKTTLKEE 183
QV Q+E L K EEL + E+ E ++L + L E +T L E
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 184 VNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQA 243
E++ R + + ++ ++ EE+EER + N +K + QDL+ QLD
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQ---ILQNEKKKMQAHIQDLEEQLD-- 960
Query: 244 LQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQ----MQRMKLQ 299
E E R ++ + ++ + K + ++++ + +Q ++ KL
Sbjct: 961 ----------------EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLM 1004
Query: 300 IATLLQMKGSQTEFEQQERLLAMLEQKNG-EIKHLLGEIRNLEKFKNLYDSMESKPSVDS 358
+ + E E++ + LA + K I L ++ EK + + + K ++
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET 1064
Query: 359 GTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKA---LFESQRALDIERKLFANER 415
L+D LQ ++D L ++ + EL + AL + R+L A
Sbjct: 1065 TDLQDQIAE---LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIA 1121
Query: 416 CLQLSESENMKLRAKLDELK---------LKYEPEETVEVPV----LKKRREVLPVDITT 462
LQ R K ++ K LK E E+T++ L+ +RE ++
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181
Query: 463 AKDACVNN----------------SALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVS 506
A + N L ++ + K + LE +N +L V
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241
Query: 507 IYTPVVSLSPHKNLPVDMQLKK 528
+ V + S HK +D Q+++
Sbjct: 1242 VLQQVKAESEHKRKKLDAQVQE 1263
Score = 45.1 bits (105), Expect = 2e-04
Identities = 89/457 (19%), Positives = 187/457 (40%), Gaps = 73/457 (15%)
Query: 168 IELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEK----EEREKEAVSYY 223
+++T E EE+ +++ +Q ++E + + R+ +L EEK E+ + E +
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 224 NALE-KARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSL 282
A E +AR+A + + +L++ L S E E+R ++ + M+ Q L
Sbjct: 905 EAEEMRARLAAK--KQELEEILHDL-------ESRVEEEEERNQILQNEKKKMQAHIQDL 955
Query: 283 KKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEI---KHLLGE--- 336
++Q + E+ R KLQ L+ ++ + ++ E + +LE +N + K L+ +
Sbjct: 956 EEQ--LDEEEGARQKLQ----LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIA 1009
Query: 337 ------IRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEI--ESTKGE 388
EK KNL + +K V LE+ + + +L+ +++ E+T +
Sbjct: 1010 ECSSQLAEEEEKAKNL-AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 389 LSIQRMKALFESQRALDIERKLFANERCLQLSESENM----------KLRAKLDELKLKY 438
I ++A + + L + +K + L + E + +L+A++ EL+ +
Sbjct: 1069 DQIAELQAQIDELK-LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDF 1127
Query: 439 EPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDNN 498
E E+ K++R+ L E+ L + E+T + ++
Sbjct: 1128 ESEKASRNKAEKQKRD------------------LSEELEALKTELEDTLDTTAAQQELR 1169
Query: 499 LQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEAL--------SERSG 550
+ E+ V+ + KN +Q +++ L + E + G
Sbjct: 1170 TKREQEVAELKKALE-EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQG 1228
Query: 551 NTPNSPRLAAESKLQTEVKEGKETSSKLEKETCKKLH 587
++ LA E K+ +VK E K ++LH
Sbjct: 1229 LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELH 1265
Score = 38.5 bits (88), Expect = 0.018
Identities = 40/210 (19%), Positives = 91/210 (43%), Gaps = 31/210 (14%)
Query: 266 AAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQ 325
A ++QL ++KV ++ Q R+ ++ LLQ+ + E + ++ L +++
Sbjct: 807 AKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKE 866
Query: 326 KNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIEST 385
K +++ GE+ +E+ LE+ + LQ + + L E E
Sbjct: 867 KQTKVE---GELEEMER-------------KHQQLLEEKNILAEQLQAETE-LFAEAEEM 909
Query: 386 KGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPEE--- 442
+ L+ ++ + + D+E ++ E Q+ ++E K++A + +L+ + + EE
Sbjct: 910 RARLAAKKQEL---EEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 966
Query: 443 --------TVEVPVLKKRREVLPVDITTAK 464
T E + K E+L ++ +K
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEILLLEDQNSK 996
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 82.8 bits (203), Expect = 8e-16
Identities = 111/486 (22%), Positives = 211/486 (43%), Gaps = 90/486 (18%)
Query: 8 NLRCRLKEAEEERLKAAQYGLQL-VESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREV 66
N +C E ++RL+ L + VE N LDK + + ++Q+ Q E+
Sbjct: 1412 NSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAEL 1471
Query: 67 ELKSRMLESLSCECEAIKQQQKMHLEKLE--EQLSRSHGQEVNELKTKIEKLKVELDEAR 124
E + SLS E +K + L+ LE ++ +++ QE+++L +I + + E
Sbjct: 1472 EASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHEL- 1530
Query: 125 LSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEV 184
+++K Q+DH+K L EE +E E ++L +Q+EL +++S E
Sbjct: 1531 ---EKVKKQLDHEKSELQTSLEE----AEASLEHEEGKILRIQLELNQVKS------EID 1577
Query: 185 NELQYRQEQLELLITNLMRQVD-----------------RLKEEKE-----------ERE 216
++ + E+L+ L N +R V+ R+K++ E
Sbjct: 1578 RKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHAN 1637
Query: 217 KEAVSYYNALEKARVANQDLQVQLDQAL-------QQALDPNSKGNSLFAEVEDRRAAME 269
++A L + +D Q+ LD A+ +Q + N + AEVE+ RA++E
Sbjct: 1638 RQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLE 1697
Query: 270 RQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGE 329
R K+ Q L + E++Q + Q +L+ K ++L + Q GE
Sbjct: 1698 RTERGRKMAEQELLDAS----ERVQLLHTQNTSLINTK---------KKLETDISQIQGE 1744
Query: 330 IKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGEL 389
++ ++ E RN E+ ++K ++ M + L KE +++
Sbjct: 1745 MEDIVQEARNAEE--------KAKKAITDAA------------MMAEELKKEQDTS---A 1781
Query: 390 SIQRMKALFESQRALDIERKL-FANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPV 448
++RMK E Q D++ +L A + L+ + + KL A++ EL+ + E E+ V
Sbjct: 1782 HLERMKKNME-QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEA 1840
Query: 449 LKKRRE 454
+K R+
Sbjct: 1841 VKGLRK 1846
Score = 67.4 bits (163), Expect = 4e-11
Identities = 126/628 (20%), Positives = 259/628 (41%), Gaps = 111/628 (17%)
Query: 9 LRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEM----MTMTESYEQEKYTLQR 64
L ++KE E + +L + +L+++ + + ++ +T+ + E+EK+ +
Sbjct: 919 LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK-VEKEKHATEN 977
Query: 65 EV----ELKSRMLESLSCECEAIKQQQKMHLEKLEE-QLSRSHGQEVNELKTKIEKLKVE 119
+V E + + E+++ + K Q+ H + L++ Q+ + + KTK+E+ +
Sbjct: 978 KVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDD 1037
Query: 120 LDEARLSEKQLKHQVDHQKELLSCK---SEELRVMSERVQESMSS-------EMLALQIE 169
L+ + EK+L ++ K L ++E + +E ++ ++ EM LQ +
Sbjct: 1038 LEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGK 1097
Query: 170 LTEMESMKTTLKEEVNELQYRQEQLELLI--------------TNLMRQVDRLKEEKEER 215
+ + +++ L++++ ELQ R E+LE I ++L R+++ + E EE
Sbjct: 1098 IEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1157
Query: 216 EKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISM 275
+ +K Q ++ L+++ L + +L + D A + Q+ S+
Sbjct: 1158 GGATSAQIEMNKKREAEFQKMRRDLEES---TLQHEATAAALRKKHADSVAELGEQIDSL 1214
Query: 276 KVKYQSLKKQN----------VFNREQMQRMKLQIATLL-----QMKGSQTEFEQQERLL 320
+ Q L+K+ N E + + K + Q+ +T+ E+Q+RL+
Sbjct: 1215 QRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLI 1274
Query: 321 -------AMLEQKNGEIKHLLGE---------------IRNLEKFKNLYDSMESKPSVDS 358
A L ++GE L E + +E+ K + S +
Sbjct: 1275 NELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLA 1334
Query: 359 GTLEDNTYYTDL--------------LQMKLDNLNKEIES--TKGEL-SIQRMKALFE-- 399
L+ + DL LQ + N E+ TK E +IQR + L E
Sbjct: 1335 HALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 400 ---SQRALDIERKLFA-NERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREV 455
+QR D E + A N +C L E +L+ ++++L + E + + KK+R
Sbjct: 1395 KKLAQRLQDAEEHVEAVNSKCASL-EKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNF 1453
Query: 456 LPV---------DITTAKDACVNNS-ALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSV 505
V + +A S +L E++++ EE+ +L+ N L++ +
Sbjct: 1454 DKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEI 1513
Query: 506 SIYTPVVSLSP---HKNLPVDMQLKKEK 530
S T ++ H+ V QL EK
Sbjct: 1514 SDLTEQIAEGGKHIHELEKVKKQLDHEK 1541
Score = 64.7 bits (156), Expect = 2e-10
Identities = 98/443 (22%), Positives = 182/443 (41%), Gaps = 74/443 (16%)
Query: 15 EAEEERLKAAQYGLQLVESQ-----NELQNQLDKCRNEMMTMTESYEQEKYTLQREVELK 69
E EE ++ Q L V+S+ E +LD+ + + + ES + TL E+ +
Sbjct: 1556 EHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQS---TLDAEIRSR 1612
Query: 70 SRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTK------IEKLKVELDEA 123
+ L IK++ + L ++E QL+ ++ Q L+ ++ ++ LD+A
Sbjct: 1613 NDALR--------IKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDA 1664
Query: 124 RLSEKQLKHQ---VDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTL 180
+ LK Q V+ + L+ + EELR ER + ++ E E + +
Sbjct: 1665 IRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGR---------KMAEQELLDAS- 1714
Query: 181 KEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQL 240
E V L + L L + +++ E E+ +EA NA EKA+ A D +
Sbjct: 1715 -ERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEA---RNAEEKAKKAITDAAMMA 1770
Query: 241 DQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQI 300
++ ++ +D A +ER +M+ + L+ ++L
Sbjct: 1771 EELKKE---------------QDTSAHLERMKKNMEQTVKDLQ------------LRLDE 1803
Query: 301 ATLLQMKGSQTEFEQQERLLAMLEQK-NGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSG 359
A L +KG + + ++ E + LE + E KH + ++ L K + + + D
Sbjct: 1804 AEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRK 1863
Query: 360 TLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQL 419
+ D LQ K+ ++ E + + ++ K R L E + A ER +
Sbjct: 1864 NILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKF-----RKLQHELEE-AKERA-DI 1916
Query: 420 SESENMKLRAKLDELKLKYEPEE 442
+ES+ KLR K E+ K EE
Sbjct: 1917 AESQVNKLRVKSREVHTKVISEE 1939
Score = 62.0 bits (149), Expect = 2e-09
Identities = 119/608 (19%), Positives = 255/608 (41%), Gaps = 84/608 (13%)
Query: 13 LKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRM 72
LK AE E+ + A + +++ EL K R E+ + QEK LQ +V+ ++
Sbjct: 844 LKSAETEK-EMANMKEEFEKTKEELAKTEAK-RKELEEKMVTLMQEKNDLQLQVQAEADA 901
Query: 73 LESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLKH 132
L C+ + + + K++E R+ +E + +K K+E DE +LK
Sbjct: 902 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE-DEC----SELKK 956
Query: 133 QVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKE----EVNELQ 188
+D EL K E+ + +E ++++ EM L + ++ K L+E +++LQ
Sbjct: 957 DID-DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1015
Query: 189 YRQEQLELLI---TNLMRQVDRLKEEKEEREKEAVSYYNA-------LEKARVANQDLQV 238
++++ L T L +QVD L+ E+ +K + A L+ A+ + D +
Sbjct: 1016 MEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTEN 1075
Query: 239 QLDQALQQALDPNSKGNSLFAEVEDRRA---AMERQLISMKVKYQSLKKQNVFNREQMQR 295
Q ++ + ++L ++ED +A +++++ ++ + + L+++ R +
Sbjct: 1076 DKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAK 1135
Query: 296 MKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPS 355
+ Q + L + + E + LE+ G +I +K + + M +
Sbjct: 1136 AEKQRSDLSR---------ELEEISERLEEAGGATS---AQIEMNKKREAEFQKM--RRD 1181
Query: 356 VDSGTLEDNTYYTDLLQMKLDN---LNKEIESTKGELSIQRMKALFESQRALDIERKLFA 412
++ TL+ L + D+ L ++I+ S+QR+K E +++ E K+
Sbjct: 1182 LEESTLQHEATAAALRKKHADSVAELGEQID------SLQRVKQKLEKEKS---ELKMEI 1232
Query: 413 NERCLQLSESENMK---------LRAKLDELKLKYEPEETV--EVPVLKKRREVLPVDIT 461
N+ + K L +L E+K K E ++ + E+ K R + +
Sbjct: 1233 NDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFS 1292
Query: 462 ---TAKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHK 518
KDA V+ + G + + ++ + LE+ K+ S + + H
Sbjct: 1293 RQLDEKDAMVSQLSRGKQAF-----TQQIEELKRQLEEET----KAKSTLAHALQSARHD 1343
Query: 519 NLPVDMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKL 578
+ Q ++E+ +A+A +R + NS +K +T+ + E +
Sbjct: 1344 CDLLREQYEEEQ----------EAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEA 1393
Query: 579 EKETCKKL 586
+K+ ++L
Sbjct: 1394 KKKLAQRL 1401
Score = 48.5 bits (114), Expect = 2e-05
Identities = 77/364 (21%), Positives = 149/364 (40%), Gaps = 66/364 (18%)
Query: 128 KQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNEL 187
K L + +KE+ + K E E E+ + + E+E TL +E N+L
Sbjct: 841 KPLLKSAETEKEMANMKEEF---------EKTKEELAKTEAKRKELEEKMVTLMQEKNDL 891
Query: 188 QYR-----------QEQLELLITNLMRQVDRLKEEKEERE-KEAVSYYNALEKARVANQ- 234
Q + +E+ + LI ++ ++KE E E +E ++ +K ++ ++
Sbjct: 892 QLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 951
Query: 235 --------DLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKK-- 284
DL++ L + ++ +K +L E+ A ++ + + + ++L++
Sbjct: 952 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM----AGLDETIAKLTKEKKALQEAH 1007
Query: 285 QNVFNREQMQRMKLQIATLLQMKGSQT------EFEQQERLLAMLEQK----NGEIKHLL 334
Q + QM+ K+ T + K Q EQ+++L LE+ G++K
Sbjct: 1008 QQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQ 1067
Query: 335 GEIRNLEKFKNLYDSMESKPSVD----SGTLEDNTYYTDLLQMKLDNLNKEIESTKGELS 390
+ E K + K + G +ED LQ K+ L IE + E+
Sbjct: 1068 ESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIE 1127
Query: 391 IQR-MKALFESQRALDIERKLFANERCLQLS--------------ESENMKLRAKLDELK 435
+R +A E QR+ D+ R+L L+ + E+E K+R L+E
Sbjct: 1128 AERASRAKAEKQRS-DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEST 1186
Query: 436 LKYE 439
L++E
Sbjct: 1187 LQHE 1190
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 81.6 bits (200), Expect = 2e-15
Identities = 127/625 (20%), Positives = 275/625 (44%), Gaps = 78/625 (12%)
Query: 6 ITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQRE 65
IT L+CRL+E + L+ E+Q +L + DK E M + E++ +Q
Sbjct: 230 ITILQCRLQELQ----------LEFTETQ-KLTLKKDKFLQEKDEMLQELEKKLTQVQNS 278
Query: 66 VELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARL 125
+ K + LE C ++ K E + +S E L+ +++KLK L+EA+
Sbjct: 279 LLKKEKELEKQQCMATELEMTVK------EAKQDKSKEAECKALQAEVQKLKNSLEEAKQ 332
Query: 126 SEKQLKHQVDHQKE---LLSCKSEELRVMSER---VQESMSSEMLALQIELTEMESMKTT 179
E+ Q KE L C E+ + ++ + + + + LQ EL ++ +
Sbjct: 333 QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSM 392
Query: 180 LKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREK----EAVSYYNALEKARVANQD 235
++E + R E+L L ++ +R+++ +EK + +K + + + L++ + +++
Sbjct: 393 AEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHRE 452
Query: 236 ---LQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISM----KVKYQSLKKQNVF 288
++ +L++ LQ+A + ++ ME +L ++ K K ++LK+ +
Sbjct: 453 QGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRK 512
Query: 289 NREQMQRMKLQI-ATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEI-----RNLEK 342
E+ + ++ ++ Q++ S ++ ++++ L ++ K L + + L+K
Sbjct: 513 LEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQK 572
Query: 343 FKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQR 402
K+ + +K + D+ + + DL Q L+ LN TK S+Q+ + ++
Sbjct: 573 EKHYLQTTITKEAYDALSRKSAACQDDLTQ-ALEKLNHVTSETK---SLQQSLTQTQEKK 628
Query: 403 ALDIERKLFANERCLQLSESENMKLRA--------------KLDELK---LKYEPEETVE 445
A +E ++ A E ++ +E KLR KL+E+ L+++ + +
Sbjct: 629 A-QLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQND 687
Query: 446 VPVLKKRREVL---PVDITTAKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLE 502
+ +L + E L ++ K+ + + E LP +C L N Q+
Sbjct: 688 LKMLAAKEEQLREFQEEMAALKENLLEDDK---EPCCLPQWSVPKDTC--RLYRGNDQIM 742
Query: 503 KSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEALSERSGNT--PNSPRLAA 560
++ + ++ K + QL+++ K + + D E S NT P+SP +
Sbjct: 743 TNLEQWAKQQKVANEK---LGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSP---S 796
Query: 561 ESKLQTEVKEGKETSSKLEKETCKK 585
S L + + ++ + KL+KE +K
Sbjct: 797 HSHLHSVMVHLQQENKKLKKEIEEK 821
Score = 80.1 bits (196), Expect = 5e-15
Identities = 137/572 (23%), Positives = 252/572 (44%), Gaps = 92/572 (16%)
Query: 11 CRLKEAEEERLKAAQYGLQLVESQN---ELQNQLDKCRNEMMTMTESYEQEKYTLQREVE 67
C ++E +E + + ++ ++ + + EL+N+L C N ++ E+EK ++ + +
Sbjct: 85 CMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKL-ACSNALVL-----EREKALIKLQAD 138
Query: 68 LKS-----RMLESLSCECEAIK------QQQK----MHLEKLEEQLS--RSHGQEVNELK 110
S R S S ECE IK Q+QK +H+E+ + + R + V+E K
Sbjct: 139 FASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQK 198
Query: 111 TKIEK--LKVELDEARLSEKQLKH--QVDHQKELLSCKSEELRVMSERVQESMSSEMLAL 166
I K +K+ELD L E+ H + D +L C+ +EL++ Q+ + L
Sbjct: 199 RNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFL 258
Query: 167 QIELTEMESMKTTLKEEVNELQYRQEQLE---LLITNLMRQVDRLKEEKEER------EK 217
Q + ++ ++ L + N L ++++LE + T L V K++K + +
Sbjct: 259 QEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQA 318
Query: 218 EAVSYYNALEKAR-----VANQDLQVQLDQA-----LQQALDPNSKGNSLFAEVEDRRAA 267
E N+LE+A+ A Q Q + + A L+ KG L + D
Sbjct: 319 EVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQE 378
Query: 268 MERQLISMKVKYQSLKKQNVFNREQMQRMKLQIA-TLLQMKGSQTEFEQQERLLAMLEQK 326
++R+L ++ + +K+ NR++++ + L+++ L +++ S E Q ++ +A + K
Sbjct: 379 LQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMK 438
Query: 327 NGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTK 386
++ L++ K+ + + S+ ED T LL+ K + L K E K
Sbjct: 439 MNDM---------LDRIKHQH---REQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEK 486
Query: 387 ---GELSIQRM------KALFESQRALDIERK-LFANERC--LQLSESEN------MKLR 428
GEL R K L E+ R L+ E + L A +C QL S N ++
Sbjct: 487 LMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQ 546
Query: 429 AKLDELKLKYEPEETVEVPV---LKKRREVLPVDIT-TAKDACVNNSA-----LGGEVYR 479
E+ L+ E +++ + L+K + L IT A DA SA L + +
Sbjct: 547 DLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEK 606
Query: 480 LPPQKEETQSCPNSL---EDNNLQLEKSVSIY 508
L ET+S SL ++ QLE+ + Y
Sbjct: 607 LNHVTSETKSLQQSLTQTQEKKAQLEEEIIAY 638
Score = 36.6 bits (83), Expect = 0.069
Identities = 68/316 (21%), Positives = 137/316 (43%), Gaps = 48/316 (15%)
Query: 34 QNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEK 93
Q++L L+K N + + T+S +Q +L + E K+++ E E I +++M +K
Sbjct: 597 QDDLTQALEKL-NHVTSETKSLQQ---SLTQTQEKKAQLEE------EIIAYEERM--KK 644
Query: 94 LEEQLSRSHG-QEVNELKTKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMS 152
L +L + G + +EL+ K+E ++ + Q +HQ D ++L+ K E+LR
Sbjct: 645 LNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQND--LKMLAAKEEQLREFQ 702
Query: 153 ERVQESMSSEMLALQIELTEMESMKTTLKE-----EVNELQYRQEQLELLITNLMRQVDR 207
E EM AL+ L E + L + + L +Q+ + +Q
Sbjct: 703 E--------EMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKV 754
Query: 208 LKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAA 267
E+ + +E V Y L + D+ +A PN+ S +
Sbjct: 755 ANEKLGNQLREQVKYIAKLSGEK----------DREPTRASSPNTTRPS-----SPSHSH 799
Query: 268 MERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKN 327
+ ++ ++ + + LKK+ ++M+ ++ T + S+TE Q+E++ L K
Sbjct: 800 LHSVMVHLQQENKKLKKE--IEEKKMKAENTRLCT-KALGPSRTESTQREKVCGTLGWKG 856
Query: 328 GEIKHLLGEIRNLEKF 343
+ +G+ +L K+
Sbjct: 857 --LPQDMGQRMDLTKY 870
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 81.3 bits (199), Expect = 2e-15
Identities = 157/683 (22%), Positives = 280/683 (40%), Gaps = 112/683 (16%)
Query: 4 DIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRN------EMMTMTESYEQ 57
D + + R ++AE E + Q QL E +N LQ QL EM + +Q
Sbjct: 859 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 918
Query: 58 EKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLK 117
E + E+E + E + +A +++ + LEEQL +E K ++EK+
Sbjct: 919 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE---EEAARQKLQLEKVT 975
Query: 118 VELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQ--------------------- 156
E +L ++ L +D Q LS +E +++ ER+
Sbjct: 976 AEAKIKKLEDEILV--MDDQNNKLS---KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 157 --ESMSSEM-LALQIE---LTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKE 210
ESM SE+ + L+ E E+E +K L+ + ++ + L+ I L Q+ + +E
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 211 EKEER----EKEAVSYYNALEKARVAN---QDLQVQLD-------QALQQALDPNSKGNS 256
E + + E NAL+K R DLQ LD +A +Q D + +
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 257 LFAEVEDR----------RAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQM 306
L E+ED RA E+++ +K ++L ++ + Q+Q M+ + A ++
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLK---KALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 307 KGSQTEFEQQERLLAMLEQKNGEIKH----LLGEIRNLEKFKNLYDSMESKPSVDSGTLE 362
Q EQ +R A L++ ++ L GE+R L + K + + K L+
Sbjct: 1208 LTEQ--LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 363 ----DNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQ 418
D L K+ L E+ES G L+ KA+ ++ + +L + LQ
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 419 LSESENMKLRAKLDELK-----LKYEPEETVEVPV-LKKRREVLPVDITTAK----DACV 468
+ + + KL +L+ L+ + +E +E L++ L + ++ +K D
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 469 NNSAL-------GGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLP 521
AL E+ L Q EE + + LE +L++ + VV L + L
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD--DLVVDLDNQRQLV 1443
Query: 522 VDMQLKKEKKCVKLIGVP-------ADAEALSERSGNTPNSPRLAAESKLQ--TEVKEGK 572
+++ KK++K +L+ AD +E + L+ L+ E KE
Sbjct: 1444 SNLE-KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 573 ETSSKLEKETCKKLHPILYVSSK 595
E ++K+ K + L VSSK
Sbjct: 1503 ERTNKMLKAEMEDL-----VSSK 1520
Score = 70.5 bits (171), Expect = 4e-12
Identities = 111/577 (19%), Positives = 233/577 (40%), Gaps = 84/577 (14%)
Query: 22 KAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECE 81
KAA Y +L +++N LQ +LD +++ ++ Q L +E K R + L E +
Sbjct: 1411 KAAAYD-KLEKTKNRLQQELD----DLVVDLDNQRQ----LVSNLEKKQRKFDQLLAEEK 1461
Query: 82 AIKQQQKMHLEKLEEQLSRSHG---------QEVNELKTKIEK----LKVELDEARLSEK 128
I + ++ E + +E E K ++E+ LK E+++ S+
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1521
Query: 129 QLK---HQVDHQKELLSCKSEELRVMSERVQESM-SSEMLALQIELTEMESMKTTLKEEV 184
+ H+++ K L + EE++ E +++ + ++E L++E+ M+++K + +
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN-MQALKGQFERD- 1579
Query: 185 NELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQAL 244
LQ R EQ E L RQ+ + E E+ K+ A +K +DL++Q D A+
Sbjct: 1580 --LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 245 QQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLL 304
+ + + L A+++D + +E S + + K E ++ K A L+
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK-------ENEKKAKSLEADLM 1690
Query: 305 QMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDN 364
Q++ E+ + Q + E + L E+ + +N + +
Sbjct: 1691 QLQEDLAAAERARK------QADLEKEELAEELASSLSGRNALQDEKRR----------- 1733
Query: 365 TYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESEN 424
L+ ++ L +E+E +G + + +Q+A + +L Q +ES
Sbjct: 1734 ------LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 425 MKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQK 484
+L + EL+ K E K L I ++ ++ +
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE-------------QVEQEA 1834
Query: 485 EETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEA 544
E Q+ SL+ + +L++ ++ + + + + + EK ++ + E
Sbjct: 1835 REKQAATKSLKQKDKKLKEI------LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 545 LSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKE 581
E S + R KLQ E+ E E++ + +E
Sbjct: 1889 AEEESQRINANRR-----KLQRELDEATESNEAMGRE 1920
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/538 (21%), Positives = 228/538 (42%), Gaps = 61/538 (11%)
Query: 57 QEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKL 116
QE+ +E EL+ E E + +QK E+ L + Q EL + E++
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 117 KVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESM 176
+V L + +++ H+++ + E + ++L+ +ER + M+ +ML L+ +L E E+
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ--AER--KKMAQQMLDLEEQLEEEEAA 965
Query: 177 KTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDL 236
+ L+ E + + ++LE I + Q ++L +E++ E+ DL
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI--------------SDL 1011
Query: 237 QVQLDQALQQALD---PNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQM 293
L + ++A + +K S+ +E+E R E+ ++ + L+ EQ+
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 294 QRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESK 353
++ QIA L+M+ ++ E E+ + LA L+ + + + L +IR LE ++ D E
Sbjct: 1072 ADLQAQIAE-LKMQLAKKE-EELQAALARLDDEIAQKNNALKKIRELE--GHISDLQEDL 1127
Query: 354 PSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFAN 413
S + + DL + +L+ L E+E T + Q+ Q +++ L
Sbjct: 1128 DSERAARNKAEKQKRDLGE-ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL--- 1183
Query: 414 ERCLQLSESENMKLRAKLDELKLKYE---PEETVEVPVLKKRREVLPVDITTAKDACVNN 470
+ E A++ E++ K+ E T ++ K+ + L + T + N
Sbjct: 1184 -------DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK---EN 1233
Query: 471 SALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVS--------IYTPVVSLSPHKNLPV 522
+ L GE+ L K+E + LE +L+ S + V L
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293
Query: 523 DMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEK 580
M + E K +KL D +LS + +T + LQ E ++ S+KL +
Sbjct: 1294 GMLNEAEGKAIKL---AKDVASLSSQLQDT--------QELLQEETRQKLNVSTKLRQ 1340
Score = 58.5 bits (140), Expect = 2e-08
Identities = 91/391 (23%), Positives = 161/391 (41%), Gaps = 74/391 (18%)
Query: 133 QVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQE 192
QV Q+E + K +EL+ ER Q++ + EL E+E + L EE N LQ + +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKA--------ENELKELEQKHSQLTEEKNLLQEQLQ 897
Query: 193 QLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNS 252
L RL +K+E E+ LE+ Q LQ + + QQ LD
Sbjct: 898 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD--- 954
Query: 253 KGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTE 312
+E QL + Q L+ + V ++++++ +I L M +
Sbjct: 955 ---------------LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI---LVMDDQNNK 996
Query: 313 FEQQERLLAMLEQKNGEIKHLLGE----IRNLEKFKNLYDSMESKPSVDSGTLEDNTYYT 368
++ +L LE++ ++ L E +NL K KN ++SM S+ LE
Sbjct: 997 LSKERKL---LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE-------LEVRLKKE 1046
Query: 369 DLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLR 428
+ + +L+ L +++E + F Q A D++ ++ + L E E
Sbjct: 1047 EKSRQELEKLKRKLEGDASD---------FHEQIA-DLQAQIAELKMQLAKKEEELQAAL 1096
Query: 429 AKLDELKLKYEPEETVEVPVLKKRREV------LPVDITTAKDACVNNSA------LGGE 476
A+LD+ E + LKK RE+ L D+ + + A N A LG E
Sbjct: 1097 ARLDD-------EIAQKNNALKKIRELEGHISDLQEDLDSERAA--RNKAEKQKRDLGEE 1147
Query: 477 VYRLPPQKEETQSCPNSLEDNNLQLEKSVSI 507
+ L + E+T + ++ + E+ V++
Sbjct: 1148 LEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Score = 38.5 bits (88), Expect = 0.018
Identities = 65/337 (19%), Positives = 135/337 (40%), Gaps = 24/337 (7%)
Query: 266 AAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQ 325
A ++QL +MKV ++ Q R+ ++ LLQ+ + E + +E L ++
Sbjct: 807 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKE 866
Query: 326 K----NGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKE 381
+ E+K L + L + KNL + E+ + +L+ + E
Sbjct: 867 RQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHE 926
Query: 382 IESTKGE-------LSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKL--- 431
+E+ E L +R K +Q+ LD+E +L E Q + E + AK+
Sbjct: 927 MEARLEEEEDRGQQLQAERKKM---AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 983
Query: 432 -DELKLKYEPEETV--EVPVLKKRREVLPVDITTAKDACVNNSALGGE----VYRLPPQK 484
DE+ + + + E +L++R L ++ ++ N + L + + L +
Sbjct: 984 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1043
Query: 485 EETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEA 544
++ + LE +LE S + ++ + + MQL K+++ ++ D E
Sbjct: 1044 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1103
Query: 545 LSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKE 581
+ + S LQ ++ + +K EK+
Sbjct: 1104 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Score = 32.0 bits (71), Expect = 1.7
Identities = 27/96 (28%), Positives = 42/96 (43%), Gaps = 1/96 (1%)
Query: 13 LKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRM 72
L + E+ER A QY Q E N QL + E ++ + LQRE++ +
Sbjct: 1855 LLQVEDERKMAEQYKEQ-AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Query: 73 LESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNE 108
E++ E A+K + + E RS G+ V E
Sbjct: 1914 NEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1949
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 81.3 bits (199), Expect = 2e-15
Identities = 157/683 (22%), Positives = 280/683 (40%), Gaps = 112/683 (16%)
Query: 4 DIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRN------EMMTMTESYEQ 57
D + + R ++AE E + Q QL E +N LQ QL EM + +Q
Sbjct: 866 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 925
Query: 58 EKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLK 117
E + E+E + E + +A +++ + LEEQL +E K ++EK+
Sbjct: 926 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE---EEAARQKLQLEKVT 982
Query: 118 VELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQ--------------------- 156
E +L ++ L +D Q LS +E +++ ER+
Sbjct: 983 AEAKIKKLEDEILV--MDDQNNKLS---KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 157 --ESMSSEM-LALQIE---LTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKE 210
ESM SE+ + L+ E E+E +K L+ + ++ + L+ I L Q+ + +E
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097
Query: 211 EKEER----EKEAVSYYNALEKARVAN---QDLQVQLD-------QALQQALDPNSKGNS 256
E + + E NAL+K R DLQ LD +A +Q D + +
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 257 LFAEVEDR----------RAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQM 306
L E+ED RA E+++ +K ++L ++ + Q+Q M+ + A ++
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLK---KALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 307 KGSQTEFEQQERLLAMLEQKNGEIKH----LLGEIRNLEKFKNLYDSMESKPSVDSGTLE 362
Q EQ +R A L++ ++ L GE+R L + K + + K L+
Sbjct: 1215 LTEQ--LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 363 ----DNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQ 418
D L K+ L E+ES G L+ KA+ ++ + +L + LQ
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 419 LSESENMKLRAKLDELK-----LKYEPEETVEVPV-LKKRREVLPVDITTAK----DACV 468
+ + + KL +L+ L+ + +E +E L++ L + ++ +K D
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 469 NNSAL-------GGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLP 521
AL E+ L Q EE + + LE +L++ + VV L + L
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD--DLVVDLDNQRQLV 1450
Query: 522 VDMQLKKEKKCVKLIGVP-------ADAEALSERSGNTPNSPRLAAESKLQ--TEVKEGK 572
+++ KK++K +L+ AD +E + L+ L+ E KE
Sbjct: 1451 SNLE-KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 573 ETSSKLEKETCKKLHPILYVSSK 595
E ++K+ K + L VSSK
Sbjct: 1510 ERTNKMLKAEMEDL-----VSSK 1527
Score = 70.5 bits (171), Expect = 4e-12
Identities = 111/577 (19%), Positives = 233/577 (40%), Gaps = 84/577 (14%)
Query: 22 KAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECE 81
KAA Y +L +++N LQ +LD +++ ++ Q L +E K R + L E +
Sbjct: 1418 KAAAYD-KLEKTKNRLQQELD----DLVVDLDNQRQ----LVSNLEKKQRKFDQLLAEEK 1468
Query: 82 AIKQQQKMHLEKLEEQLSRSHG---------QEVNELKTKIEK----LKVELDEARLSEK 128
I + ++ E + +E E K ++E+ LK E+++ S+
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1528
Query: 129 QLK---HQVDHQKELLSCKSEELRVMSERVQESM-SSEMLALQIELTEMESMKTTLKEEV 184
+ H+++ K L + EE++ E +++ + ++E L++E+ M+++K + +
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN-MQALKGQFERD- 1586
Query: 185 NELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQAL 244
LQ R EQ E L RQ+ + E E+ K+ A +K +DL++Q D A+
Sbjct: 1587 --LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 245 QQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLL 304
+ + + L A+++D + +E S + + K E ++ K A L+
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK-------ENEKKAKSLEADLM 1697
Query: 305 QMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDN 364
Q++ E+ + Q + E + L E+ + +N + +
Sbjct: 1698 QLQEDLAAAERARK------QADLEKEELAEELASSLSGRNALQDEKRR----------- 1740
Query: 365 TYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESEN 424
L+ ++ L +E+E +G + + +Q+A + +L Q +ES
Sbjct: 1741 ------LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 425 MKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQK 484
+L + EL+ K E K L I ++ ++ +
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE-------------QVEQEA 1841
Query: 485 EETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEA 544
E Q+ SL+ + +L++ ++ + + + + + EK ++ + E
Sbjct: 1842 REKQAATKSLKQKDKKLKEI------LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 545 LSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKE 581
E S + R KLQ E+ E E++ + +E
Sbjct: 1896 AEEESQRINANRR-----KLQRELDEATESNEAMGRE 1927
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/538 (21%), Positives = 228/538 (42%), Gaps = 61/538 (11%)
Query: 57 QEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKL 116
QE+ +E EL+ E E + +QK E+ L + Q EL + E++
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 117 KVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESM 176
+V L + +++ H+++ + E + ++L+ +ER + M+ +ML L+ +L E E+
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ--AER--KKMAQQMLDLEEQLEEEEAA 972
Query: 177 KTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDL 236
+ L+ E + + ++LE I + Q ++L +E++ E+ DL
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI--------------SDL 1018
Query: 237 QVQLDQALQQALD---PNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQM 293
L + ++A + +K S+ +E+E R E+ ++ + L+ EQ+
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 294 QRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESK 353
++ QIA L+M+ ++ E E+ + LA L+ + + + L +IR LE ++ D E
Sbjct: 1079 ADLQAQIAE-LKMQLAKKE-EELQAALARLDDEIAQKNNALKKIRELE--GHISDLQEDL 1134
Query: 354 PSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFAN 413
S + + DL + +L+ L E+E T + Q+ Q +++ L
Sbjct: 1135 DSERAARNKAEKQKRDLGE-ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL--- 1190
Query: 414 ERCLQLSESENMKLRAKLDELKLKYE---PEETVEVPVLKKRREVLPVDITTAKDACVNN 470
+ E A++ E++ K+ E T ++ K+ + L + T + N
Sbjct: 1191 -------DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK---EN 1240
Query: 471 SALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVS--------IYTPVVSLSPHKNLPV 522
+ L GE+ L K+E + LE +L+ S + V L
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300
Query: 523 DMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEK 580
M + E K +KL D +LS + +T + LQ E ++ S+KL +
Sbjct: 1301 GMLNEAEGKAIKL---AKDVASLSSQLQDT--------QELLQEETRQKLNVSTKLRQ 1347
Score = 58.5 bits (140), Expect = 2e-08
Identities = 91/391 (23%), Positives = 161/391 (41%), Gaps = 74/391 (18%)
Query: 133 QVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQE 192
QV Q+E + K +EL+ ER Q++ + EL E+E + L EE N LQ + +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKA--------ENELKELEQKHSQLTEEKNLLQEQLQ 904
Query: 193 QLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNS 252
L RL +K+E E+ LE+ Q LQ + + QQ LD
Sbjct: 905 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD--- 961
Query: 253 KGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTE 312
+E QL + Q L+ + V ++++++ +I L M +
Sbjct: 962 ---------------LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI---LVMDDQNNK 1003
Query: 313 FEQQERLLAMLEQKNGEIKHLLGE----IRNLEKFKNLYDSMESKPSVDSGTLEDNTYYT 368
++ +L LE++ ++ L E +NL K KN ++SM S+ LE
Sbjct: 1004 LSKERKL---LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE-------LEVRLKKE 1053
Query: 369 DLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLR 428
+ + +L+ L +++E + F Q A D++ ++ + L E E
Sbjct: 1054 EKSRQELEKLKRKLEGDASD---------FHEQIA-DLQAQIAELKMQLAKKEEELQAAL 1103
Query: 429 AKLDELKLKYEPEETVEVPVLKKRREV------LPVDITTAKDACVNNSA------LGGE 476
A+LD+ E + LKK RE+ L D+ + + A N A LG E
Sbjct: 1104 ARLDD-------EIAQKNNALKKIRELEGHISDLQEDLDSERAA--RNKAEKQKRDLGEE 1154
Query: 477 VYRLPPQKEETQSCPNSLEDNNLQLEKSVSI 507
+ L + E+T + ++ + E+ V++
Sbjct: 1155 LEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Score = 38.5 bits (88), Expect = 0.018
Identities = 65/337 (19%), Positives = 135/337 (40%), Gaps = 24/337 (7%)
Query: 266 AAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQ 325
A ++QL +MKV ++ Q R+ ++ LLQ+ + E + +E L ++
Sbjct: 814 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKE 873
Query: 326 K----NGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKE 381
+ E+K L + L + KNL + E+ + +L+ + E
Sbjct: 874 RQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHE 933
Query: 382 IESTKGE-------LSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKL--- 431
+E+ E L +R K +Q+ LD+E +L E Q + E + AK+
Sbjct: 934 MEARLEEEEDRGQQLQAERKKM---AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 990
Query: 432 -DELKLKYEPEETV--EVPVLKKRREVLPVDITTAKDACVNNSALGGE----VYRLPPQK 484
DE+ + + + E +L++R L ++ ++ N + L + + L +
Sbjct: 991 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1050
Query: 485 EETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEA 544
++ + LE +LE S + ++ + + MQL K+++ ++ D E
Sbjct: 1051 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1110
Query: 545 LSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKE 581
+ + S LQ ++ + +K EK+
Sbjct: 1111 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Score = 32.0 bits (71), Expect = 1.7
Identities = 27/96 (28%), Positives = 42/96 (43%), Gaps = 1/96 (1%)
Query: 13 LKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRM 72
L + E+ER A QY Q E N QL + E ++ + LQRE++ +
Sbjct: 1862 LLQVEDERKMAEQYKEQ-AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Query: 73 LESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNE 108
E++ E A+K + + E RS G+ V E
Sbjct: 1921 NEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1956
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 81.3 bits (199), Expect = 2e-15
Identities = 157/683 (22%), Positives = 280/683 (40%), Gaps = 112/683 (16%)
Query: 4 DIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRN------EMMTMTESYEQ 57
D + + R ++AE E + Q QL E +N LQ QL EM + +Q
Sbjct: 866 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 925
Query: 58 EKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLK 117
E + E+E + E + +A +++ + LEEQL +E K ++EK+
Sbjct: 926 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE---EEAARQKLQLEKVT 982
Query: 118 VELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQ--------------------- 156
E +L ++ L +D Q LS +E +++ ER+
Sbjct: 983 AEAKIKKLEDEILV--MDDQNNKLS---KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 157 --ESMSSEM-LALQIE---LTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKE 210
ESM SE+ + L+ E E+E +K L+ + ++ + L+ I L Q+ + +E
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097
Query: 211 EKEER----EKEAVSYYNALEKARVAN---QDLQVQLD-------QALQQALDPNSKGNS 256
E + + E NAL+K R DLQ LD +A +Q D + +
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 257 LFAEVEDR----------RAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQM 306
L E+ED RA E+++ +K ++L ++ + Q+Q M+ + A ++
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLK---KALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 307 KGSQTEFEQQERLLAMLEQKNGEIKH----LLGEIRNLEKFKNLYDSMESKPSVDSGTLE 362
Q EQ +R A L++ ++ L GE+R L + K + + K L+
Sbjct: 1215 LTEQ--LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 363 ----DNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQ 418
D L K+ L E+ES G L+ KA+ ++ + +L + LQ
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 419 LSESENMKLRAKLDELK-----LKYEPEETVEVPV-LKKRREVLPVDITTAK----DACV 468
+ + + KL +L+ L+ + +E +E L++ L + ++ +K D
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 469 NNSAL-------GGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLP 521
AL E+ L Q EE + + LE +L++ + VV L + L
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD--DLVVDLDNQRQLV 1450
Query: 522 VDMQLKKEKKCVKLIGVP-------ADAEALSERSGNTPNSPRLAAESKLQ--TEVKEGK 572
+++ KK++K +L+ AD +E + L+ L+ E KE
Sbjct: 1451 SNLE-KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 573 ETSSKLEKETCKKLHPILYVSSK 595
E ++K+ K + L VSSK
Sbjct: 1510 ERTNKMLKAEMEDL-----VSSK 1527
Score = 70.5 bits (171), Expect = 4e-12
Identities = 111/577 (19%), Positives = 233/577 (40%), Gaps = 84/577 (14%)
Query: 22 KAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECE 81
KAA Y +L +++N LQ +LD +++ ++ Q L +E K R + L E +
Sbjct: 1418 KAAAYD-KLEKTKNRLQQELD----DLVVDLDNQRQ----LVSNLEKKQRKFDQLLAEEK 1468
Query: 82 AIKQQQKMHLEKLEEQLSRSHG---------QEVNELKTKIEK----LKVELDEARLSEK 128
I + ++ E + +E E K ++E+ LK E+++ S+
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1528
Query: 129 QLK---HQVDHQKELLSCKSEELRVMSERVQESM-SSEMLALQIELTEMESMKTTLKEEV 184
+ H+++ K L + EE++ E +++ + ++E L++E+ M+++K + +
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN-MQALKGQFERD- 1586
Query: 185 NELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQAL 244
LQ R EQ E L RQ+ + E E+ K+ A +K +DL++Q D A+
Sbjct: 1587 --LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 245 QQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLL 304
+ + + L A+++D + +E S + + K E ++ K A L+
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK-------ENEKKAKSLEADLM 1697
Query: 305 QMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDN 364
Q++ E+ + Q + E + L E+ + +N + +
Sbjct: 1698 QLQEDLAAAERARK------QADLEKEELAEELASSLSGRNALQDEKRR----------- 1740
Query: 365 TYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESEN 424
L+ ++ L +E+E +G + + +Q+A + +L Q +ES
Sbjct: 1741 ------LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 425 MKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQK 484
+L + EL+ K E K L I ++ ++ +
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE-------------QVEQEA 1841
Query: 485 EETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEA 544
E Q+ SL+ + +L++ ++ + + + + + EK ++ + E
Sbjct: 1842 REKQAATKSLKQKDKKLKEI------LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 545 LSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKE 581
E S + R KLQ E+ E E++ + +E
Sbjct: 1896 AEEESQRINANRR-----KLQRELDEATESNEAMGRE 1927
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/538 (21%), Positives = 228/538 (42%), Gaps = 61/538 (11%)
Query: 57 QEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKL 116
QE+ +E EL+ E E + +QK E+ L + Q EL + E++
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 117 KVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESM 176
+V L + +++ H+++ + E + ++L+ +ER + M+ +ML L+ +L E E+
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ--AER--KKMAQQMLDLEEQLEEEEAA 972
Query: 177 KTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDL 236
+ L+ E + + ++LE I + Q ++L +E++ E+ DL
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI--------------SDL 1018
Query: 237 QVQLDQALQQALD---PNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQM 293
L + ++A + +K S+ +E+E R E+ ++ + L+ EQ+
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 294 QRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESK 353
++ QIA L+M+ ++ E E+ + LA L+ + + + L +IR LE ++ D E
Sbjct: 1079 ADLQAQIAE-LKMQLAKKE-EELQAALARLDDEIAQKNNALKKIRELE--GHISDLQEDL 1134
Query: 354 PSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFAN 413
S + + DL + +L+ L E+E T + Q+ Q +++ L
Sbjct: 1135 DSERAARNKAEKQKRDLGE-ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL--- 1190
Query: 414 ERCLQLSESENMKLRAKLDELKLKYE---PEETVEVPVLKKRREVLPVDITTAKDACVNN 470
+ E A++ E++ K+ E T ++ K+ + L + T + N
Sbjct: 1191 -------DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK---EN 1240
Query: 471 SALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVS--------IYTPVVSLSPHKNLPV 522
+ L GE+ L K+E + LE +L+ S + V L
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300
Query: 523 DMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEK 580
M + E K +KL D +LS + +T + LQ E ++ S+KL +
Sbjct: 1301 GMLNEAEGKAIKL---AKDVASLSSQLQDT--------QELLQEETRQKLNVSTKLRQ 1347
Score = 58.5 bits (140), Expect = 2e-08
Identities = 91/391 (23%), Positives = 161/391 (41%), Gaps = 74/391 (18%)
Query: 133 QVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQE 192
QV Q+E + K +EL+ ER Q++ + EL E+E + L EE N LQ + +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKA--------ENELKELEQKHSQLTEEKNLLQEQLQ 904
Query: 193 QLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNS 252
L RL +K+E E+ LE+ Q LQ + + QQ LD
Sbjct: 905 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD--- 961
Query: 253 KGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTE 312
+E QL + Q L+ + V ++++++ +I L M +
Sbjct: 962 ---------------LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI---LVMDDQNNK 1003
Query: 313 FEQQERLLAMLEQKNGEIKHLLGE----IRNLEKFKNLYDSMESKPSVDSGTLEDNTYYT 368
++ +L LE++ ++ L E +NL K KN ++SM S+ LE
Sbjct: 1004 LSKERKL---LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE-------LEVRLKKE 1053
Query: 369 DLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLR 428
+ + +L+ L +++E + F Q A D++ ++ + L E E
Sbjct: 1054 EKSRQELEKLKRKLEGDASD---------FHEQIA-DLQAQIAELKMQLAKKEEELQAAL 1103
Query: 429 AKLDELKLKYEPEETVEVPVLKKRREV------LPVDITTAKDACVNNSA------LGGE 476
A+LD+ E + LKK RE+ L D+ + + A N A LG E
Sbjct: 1104 ARLDD-------EIAQKNNALKKIRELEGHISDLQEDLDSERAA--RNKAEKQKRDLGEE 1154
Query: 477 VYRLPPQKEETQSCPNSLEDNNLQLEKSVSI 507
+ L + E+T + ++ + E+ V++
Sbjct: 1155 LEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Score = 38.5 bits (88), Expect = 0.018
Identities = 65/337 (19%), Positives = 135/337 (40%), Gaps = 24/337 (7%)
Query: 266 AAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQ 325
A ++QL +MKV ++ Q R+ ++ LLQ+ + E + +E L ++
Sbjct: 814 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKE 873
Query: 326 K----NGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKE 381
+ E+K L + L + KNL + E+ + +L+ + E
Sbjct: 874 RQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHE 933
Query: 382 IESTKGE-------LSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKL--- 431
+E+ E L +R K +Q+ LD+E +L E Q + E + AK+
Sbjct: 934 MEARLEEEEDRGQQLQAERKKM---AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 990
Query: 432 -DELKLKYEPEETV--EVPVLKKRREVLPVDITTAKDACVNNSALGGE----VYRLPPQK 484
DE+ + + + E +L++R L ++ ++ N + L + + L +
Sbjct: 991 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1050
Query: 485 EETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEA 544
++ + LE +LE S + ++ + + MQL K+++ ++ D E
Sbjct: 1051 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1110
Query: 545 LSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKE 581
+ + S LQ ++ + +K EK+
Sbjct: 1111 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 81.3 bits (199), Expect = 2e-15
Identities = 157/683 (22%), Positives = 280/683 (40%), Gaps = 112/683 (16%)
Query: 4 DIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRN------EMMTMTESYEQ 57
D + + R ++AE E + Q QL E +N LQ QL EM + +Q
Sbjct: 859 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 918
Query: 58 EKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLK 117
E + E+E + E + +A +++ + LEEQL +E K ++EK+
Sbjct: 919 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE---EEAARQKLQLEKVT 975
Query: 118 VELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQ--------------------- 156
E +L ++ L +D Q LS +E +++ ER+
Sbjct: 976 AEAKIKKLEDEILV--MDDQNNKLS---KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 157 --ESMSSEM-LALQIE---LTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKE 210
ESM SE+ + L+ E E+E +K L+ + ++ + L+ I L Q+ + +E
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 211 EKEER----EKEAVSYYNALEKARVAN---QDLQVQLD-------QALQQALDPNSKGNS 256
E + + E NAL+K R DLQ LD +A +Q D + +
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 257 LFAEVEDR----------RAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQM 306
L E+ED RA E+++ +K ++L ++ + Q+Q M+ + A ++
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLK---KALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 307 KGSQTEFEQQERLLAMLEQKNGEIKH----LLGEIRNLEKFKNLYDSMESKPSVDSGTLE 362
Q EQ +R A L++ ++ L GE+R L + K + + K L+
Sbjct: 1208 LTEQ--LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 363 ----DNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQ 418
D L K+ L E+ES G L+ KA+ ++ + +L + LQ
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 419 LSESENMKLRAKLDELK-----LKYEPEETVEVPV-LKKRREVLPVDITTAK----DACV 468
+ + + KL +L+ L+ + +E +E L++ L + ++ +K D
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 469 NNSAL-------GGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLP 521
AL E+ L Q EE + + LE +L++ + VV L + L
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD--DLVVDLDNQRQLV 1443
Query: 522 VDMQLKKEKKCVKLIGVP-------ADAEALSERSGNTPNSPRLAAESKLQ--TEVKEGK 572
+++ KK++K +L+ AD +E + L+ L+ E KE
Sbjct: 1444 SNLE-KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 573 ETSSKLEKETCKKLHPILYVSSK 595
E ++K+ K + L VSSK
Sbjct: 1503 ERTNKMLKAEMEDL-----VSSK 1520
Score = 70.5 bits (171), Expect = 4e-12
Identities = 111/577 (19%), Positives = 233/577 (40%), Gaps = 84/577 (14%)
Query: 22 KAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECE 81
KAA Y +L +++N LQ +LD +++ ++ Q L +E K R + L E +
Sbjct: 1411 KAAAYD-KLEKTKNRLQQELD----DLVVDLDNQRQ----LVSNLEKKQRKFDQLLAEEK 1461
Query: 82 AIKQQQKMHLEKLEEQLSRSHG---------QEVNELKTKIEK----LKVELDEARLSEK 128
I + ++ E + +E E K ++E+ LK E+++ S+
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1521
Query: 129 QLK---HQVDHQKELLSCKSEELRVMSERVQESM-SSEMLALQIELTEMESMKTTLKEEV 184
+ H+++ K L + EE++ E +++ + ++E L++E+ M+++K + +
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN-MQALKGQFERD- 1579
Query: 185 NELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQAL 244
LQ R EQ E L RQ+ + E E+ K+ A +K +DL++Q D A+
Sbjct: 1580 --LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 245 QQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLL 304
+ + + L A+++D + +E S + + K E ++ K A L+
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK-------ENEKKAKSLEADLM 1690
Query: 305 QMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDN 364
Q++ E+ + Q + E + L E+ + +N + +
Sbjct: 1691 QLQEDLAAAERARK------QADLEKEELAEELASSLSGRNALQDEKRR----------- 1733
Query: 365 TYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESEN 424
L+ ++ L +E+E +G + + +Q+A + +L Q +ES
Sbjct: 1734 ------LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 425 MKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQK 484
+L + EL+ K E K L I ++ ++ +
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE-------------QVEQEA 1834
Query: 485 EETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEA 544
E Q+ SL+ + +L++ ++ + + + + + EK ++ + E
Sbjct: 1835 REKQAATKSLKQKDKKLKEI------LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 545 LSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKE 581
E S + R KLQ E+ E E++ + +E
Sbjct: 1889 AEEESQRINANRR-----KLQRELDEATESNEAMGRE 1920
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/538 (21%), Positives = 228/538 (42%), Gaps = 61/538 (11%)
Query: 57 QEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKL 116
QE+ +E EL+ E E + +QK E+ L + Q EL + E++
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 117 KVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESM 176
+V L + +++ H+++ + E + ++L+ +ER + M+ +ML L+ +L E E+
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ--AER--KKMAQQMLDLEEQLEEEEAA 965
Query: 177 KTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDL 236
+ L+ E + + ++LE I + Q ++L +E++ E+ DL
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI--------------SDL 1011
Query: 237 QVQLDQALQQALD---PNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQM 293
L + ++A + +K S+ +E+E R E+ ++ + L+ EQ+
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 294 QRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESK 353
++ QIA L+M+ ++ E E+ + LA L+ + + + L +IR LE ++ D E
Sbjct: 1072 ADLQAQIAE-LKMQLAKKE-EELQAALARLDDEIAQKNNALKKIRELE--GHISDLQEDL 1127
Query: 354 PSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFAN 413
S + + DL + +L+ L E+E T + Q+ Q +++ L
Sbjct: 1128 DSERAARNKAEKQKRDLGE-ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL--- 1183
Query: 414 ERCLQLSESENMKLRAKLDELKLKYE---PEETVEVPVLKKRREVLPVDITTAKDACVNN 470
+ E A++ E++ K+ E T ++ K+ + L + T + N
Sbjct: 1184 -------DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK---EN 1233
Query: 471 SALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVS--------IYTPVVSLSPHKNLPV 522
+ L GE+ L K+E + LE +L+ S + V L
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293
Query: 523 DMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEK 580
M + E K +KL D +LS + +T + LQ E ++ S+KL +
Sbjct: 1294 GMLNEAEGKAIKL---AKDVASLSSQLQDT--------QELLQEETRQKLNVSTKLRQ 1340
Score = 58.5 bits (140), Expect = 2e-08
Identities = 91/391 (23%), Positives = 161/391 (41%), Gaps = 74/391 (18%)
Query: 133 QVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQE 192
QV Q+E + K +EL+ ER Q++ + EL E+E + L EE N LQ + +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKA--------ENELKELEQKHSQLTEEKNLLQEQLQ 897
Query: 193 QLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNS 252
L RL +K+E E+ LE+ Q LQ + + QQ LD
Sbjct: 898 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD--- 954
Query: 253 KGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTE 312
+E QL + Q L+ + V ++++++ +I L M +
Sbjct: 955 ---------------LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI---LVMDDQNNK 996
Query: 313 FEQQERLLAMLEQKNGEIKHLLGE----IRNLEKFKNLYDSMESKPSVDSGTLEDNTYYT 368
++ +L LE++ ++ L E +NL K KN ++SM S+ LE
Sbjct: 997 LSKERKL---LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE-------LEVRLKKE 1046
Query: 369 DLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLR 428
+ + +L+ L +++E + F Q A D++ ++ + L E E
Sbjct: 1047 EKSRQELEKLKRKLEGDASD---------FHEQIA-DLQAQIAELKMQLAKKEEELQAAL 1096
Query: 429 AKLDELKLKYEPEETVEVPVLKKRREV------LPVDITTAKDACVNNSA------LGGE 476
A+LD+ E + LKK RE+ L D+ + + A N A LG E
Sbjct: 1097 ARLDD-------EIAQKNNALKKIRELEGHISDLQEDLDSERAA--RNKAEKQKRDLGEE 1147
Query: 477 VYRLPPQKEETQSCPNSLEDNNLQLEKSVSI 507
+ L + E+T + ++ + E+ V++
Sbjct: 1148 LEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Score = 38.5 bits (88), Expect = 0.018
Identities = 65/337 (19%), Positives = 135/337 (40%), Gaps = 24/337 (7%)
Query: 266 AAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQ 325
A ++QL +MKV ++ Q R+ ++ LLQ+ + E + +E L ++
Sbjct: 807 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKE 866
Query: 326 K----NGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKE 381
+ E+K L + L + KNL + E+ + +L+ + E
Sbjct: 867 RQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHE 926
Query: 382 IESTKGE-------LSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKL--- 431
+E+ E L +R K +Q+ LD+E +L E Q + E + AK+
Sbjct: 927 MEARLEEEEDRGQQLQAERKKM---AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 983
Query: 432 -DELKLKYEPEETV--EVPVLKKRREVLPVDITTAKDACVNNSALGGE----VYRLPPQK 484
DE+ + + + E +L++R L ++ ++ N + L + + L +
Sbjct: 984 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1043
Query: 485 EETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEA 544
++ + LE +LE S + ++ + + MQL K+++ ++ D E
Sbjct: 1044 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1103
Query: 545 LSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKE 581
+ + S LQ ++ + +K EK+
Sbjct: 1104 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 81.3 bits (199), Expect = 2e-15
Identities = 110/478 (23%), Positives = 208/478 (43%), Gaps = 55/478 (11%)
Query: 6 ITNLRCRLKEAE------EERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEK 59
+ NLR L E E EE+L++ Q L+ + + Q ++ + E++ E EK
Sbjct: 1188 VANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGP-QVEVKEVTKEVIKYKTDPEMEK 1246
Query: 60 --YTLQREVELKSRMLESLSCECEAIKQQ------QKMHLEKLEEQLSRSHGQEVNELKT 111
L+ E+ K+R++E E +K++ K ++ E QE + K
Sbjct: 1247 ELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKE 1306
Query: 112 KIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERV--------------QE 157
++ L+ +L E + + L+ + Q+E ++ K EEL + ERV +
Sbjct: 1307 EVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRA 1366
Query: 158 SMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEE--- 214
S+ ++ +EL +++ L+ E+ LQ R+ +LE + L R+ +E + E
Sbjct: 1367 EASAFAESIDVELRQIDK----LRAELRRLQRRRTELERQLEELERERQARREAEREVQR 1422
Query: 215 -REKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLI 273
+++ A E +V L Q QQA + ++ E + RR +E +L
Sbjct: 1423 LQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQARE-HALLRLQLEEEQHRRQLLEGELE 1481
Query: 274 SMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHL 333
+++ K +L+K V + K+ ++ +Q++ TE E Q RL + LE+++ + L
Sbjct: 1482 TLRRKLAALEKAEV-------KEKVVLSESVQVEKGDTEQEIQ-RLKSSLEEESRSKREL 1533
Query: 334 LGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDL----LQMKLDNLNKEIESTKGEL 389
E+ LE + + SK S + L + + L LQ++ L EI E
Sbjct: 1534 DVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATET 1593
Query: 390 SIQRMKALFES-----QRALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPEE 442
R + +S R +ER+L +R + + E +L+ +L + +K E E
Sbjct: 1594 RDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRE 1651
Score = 59.3 bits (142), Expect = 1e-08
Identities = 101/480 (21%), Positives = 213/480 (44%), Gaps = 58/480 (12%)
Query: 36 ELQNQLDKCRNEMMTMTESYEQEKYTLQREV----ELKSRMLESLSCECEAIKQQQKMHL 91
+L+ +L+ R + + E E LQ+ V E KSR E ++ E E +K Q L
Sbjct: 1012 QLREELEALRRQK----GAREAEVLLLQQRVAALAEEKSRAQEKVT-EKEVVKLQNDPQL 1066
Query: 92 EKLEEQLSRSH----------GQEVNELKTKIEKLKVE--LDEARLSEKQ-LKHQVD--H 136
E +QL H +E++ L+ K+++L+ E + E +++ K+ LK + D
Sbjct: 1067 EAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAAT 1126
Query: 137 QKELLS-CKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLE 195
++E+ + E R + +E+L +I E E+ K ++E+V E+ + E
Sbjct: 1127 EREVSDLTRQYEDEAAKARASQREKTELLR-KIWALEEENAKVVVQEKVREIVRPDPKAE 1185
Query: 196 LLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQ--LDQALQQALDPNSK 253
+ NL ++ + + E++ SY + LE R ++V+ + ++ DP +
Sbjct: 1186 SEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEME 1245
Query: 254 G--NSLFAEVEDRRAAMER---QLISMKVKYQSLK--KQNVFNREQMQRMKLQIATLLQM 306
L E+ D+ +ER ++ +K + Q+LK K V +E +Q + LQ Q
Sbjct: 1246 KELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEI-LQFQEDPQT 1304
Query: 307 KGSQTEF-----EQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSME-SKPSVDSGT 360
K E+Q++ + + ++ + + + + L + K E + + G
Sbjct: 1305 KEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGL 1364
Query: 361 LEDNTYYTDLLQMKLDNLNK------EIESTKGELSIQRMKALFESQRALDIERKLFANE 414
+ + + + + ++L ++K ++ + EL Q + E Q + ER++ +
Sbjct: 1365 RAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQ 1424
Query: 415 RCLQLSESENMKLRAKL---DELKLKYEPEETVEVPVLK-------KRREVLPVDITTAK 464
+ L E E + R K+ ++ L+ +P++ E +L+ RR++L ++ T +
Sbjct: 1425 QRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLR 1484
Score = 48.5 bits (114), Expect = 2e-05
Identities = 108/548 (19%), Positives = 226/548 (41%), Gaps = 72/548 (13%)
Query: 22 KAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECE 81
K+ Q +L+ + NQ D E + +S QE + E++ + +L + +
Sbjct: 619 KSLQQSWELLATHENHLNQ-DDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQ 677
Query: 82 AIKQ-------QQKMHLEKLEEQLSRSH--GQEVNELKTKIEKLKVELDEARLSEKQLKH 132
A KQ + + H LE Q + H GQ N L+ ++E+ L A+ + +
Sbjct: 678 AAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHR 737
Query: 133 QVDHQKELL----SCKSEELRVMSE-----RVQESMSSEMLALQIELTEMESMKTTLKEE 183
DH + L S + +E +S+ + Q+++ E+ + + E+ ++ + ++
Sbjct: 738 GHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQA 797
Query: 184 VNELQYRQEQLELLI-------------TNLMRQVDRLKEEKEEREKEAVSYYNALEKAR 230
V + + E+L L+ L ++KEE+ + Y A+ + R
Sbjct: 798 VKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVY-AINRQR 856
Query: 231 VAN---------QDLQVQLDQALQQALDPNS------KGNSLFAEVEDRRAAMERQLISM 275
+ N Q +V++ Q P+S K E +RR +E ++ S
Sbjct: 857 LQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKST 916
Query: 276 KVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKN----GEIK 331
+ + +L+ Q Q ++ ++ + + F+Q +R LA + KN E++
Sbjct: 917 QEEIWTLRNQG----PQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELE 972
Query: 332 HLLGEIRNLEKFKNLYDSMESKPSVDSGTLE-DNTYYTDLLQMK--LDNLNKEIESTKGE 388
L ++R LE + D + + +E D ++LQ++ L+ L ++ + + E
Sbjct: 973 ALQLQLRALE--QETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAE 1030
Query: 389 LSI--QRMKALFE-----SQRALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPE 441
+ + QR+ AL E ++ + E N+ L+ + + + D+L+ K E E
Sbjct: 1031 VLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEE 1090
Query: 442 ETV---EVPVLKKRREVLPVDITTAKDACV-NNSALGGEVYRLPPQKEETQSCPNSLEDN 497
+ ++ L+K R + IT + V ++A EV L Q E+ + + +
Sbjct: 1091 LSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE 1150
Query: 498 NLQLEKSV 505
+L + +
Sbjct: 1151 KTELLRKI 1158
Score = 32.7 bits (73), Expect = 0.99
Identities = 68/335 (20%), Positives = 128/335 (38%), Gaps = 50/335 (14%)
Query: 42 DKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRS 101
D ++ ++ + K TLQ+ E+ E+ + +Q L+K+ L R
Sbjct: 464 DSLGSQYRSVRQKAAGSKRTLQQRYEVLKT--ENPGDASDLQGRQLLAGLDKVASDLDRQ 521
Query: 102 HGQEVNELKTKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSS 161
L+ +E+ + D A + K+L + +E LR+ E+ + +
Sbjct: 522 EKAITGILRPPLEQGRAVQDSA-----------ERAKDLKNITNELLRIEPEKTRSTAEG 570
Query: 162 EMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVD---RLKEEKEEREKE 218
E I+ L+ V + + E L L+ +VD RL++ ++ +
Sbjct: 571 EAF---IQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWEL 627
Query: 219 AVSYYNAL-------EKARV----------------ANQDLQVQLDQALQQALDPNSKGN 255
++ N L E +RV A + L +++Q LQ A +S
Sbjct: 628 LATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLA 687
Query: 256 SLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIA-------TLLQMKG 308
S F E E ++ + ++ +L++Q + +Q K +LQ
Sbjct: 688 SRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLV 747
Query: 309 SQTEFEQQER-LLAMLEQKNGEIKHLLGEIRNLEK 342
S +E QE L+ +E K K+LL EI + E+
Sbjct: 748 SIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQ 782
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 80.9 bits (198), Expect = 3e-15
Identities = 121/620 (19%), Positives = 256/620 (41%), Gaps = 60/620 (9%)
Query: 6 ITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQRE 65
+ L+ + E E R + A +L + + L + ++ +T+ + + LQ
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDT 1313
Query: 66 VEL---KSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHG--QEVNELKTKIEKLKVEL 120
EL ++R SLS + + ++ ++ E+LEE+ H +++ L ++ +K ++
Sbjct: 1314 QELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKM 1373
Query: 121 DEA---RLSEKQLKHQVDHQKELLSCKSEELRVMSERVQES---MSSEMLALQIELTEME 174
+++ + +++K ++ E LS + EE ++++++ + E+ L ++L
Sbjct: 1374 EDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQR 1433
Query: 175 SMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQ 234
L+++ + + + + + DR + E E+E +A+S ALE+A
Sbjct: 1434 QSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKA 1493
Query: 235 DLQ---VQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNRE 291
+L+ Q ++ + E+E + A+E+Q+ MK + + L+ + +
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE----LQ 1549
Query: 292 QMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSME 351
+ KL++ LQ +Q E + Q R EQ + K L+ ++R +E L D +
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGR----DEQSEEKKKQLVRQVREME--AELEDERK 1603
Query: 352 SKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLF 411
+ + + L+M L +L I+S + + R L + K
Sbjct: 1604 QRSMAVAARKK--------LEMDLKDLEAHIDSAN-----KNRDEAIKQLRKLQAQMKDC 1650
Query: 412 ANERCLQLSESENMKLRAKLDELKLKYEPEETV----EVPVLKKRREVLPVDITTAKDAC 467
E + E + +AK +E KLK E + E+ ++ + + D
Sbjct: 1651 MRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710
Query: 468 VNNSALG-----------GEVYRLPPQKEETQSCPNSLEDN----NLQLEKSVSIYTPVV 512
N+S G + +L + EE Q + D NLQ+++ ++ +
Sbjct: 1711 ANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQ-INTDLNLE 1769
Query: 513 SLSPHKNLPVDMQLKKEKK--CVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKE 570
KN QL+++ K VKL + ++ + S + E +L E KE
Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKE 1829
Query: 571 GKETSSKLEKETCKKLHPIL 590
++ + K + T KKL +L
Sbjct: 1830 -RQAACKQVRRTEKKLKDVL 1848
Score = 77.0 bits (188), Expect = 5e-14
Identities = 108/517 (20%), Positives = 226/517 (43%), Gaps = 53/517 (10%)
Query: 12 RLKEAE--EERLKAAQYGLQ-LVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVEL 68
RL E E + +L A + LQ ++++ EL + ++ R + + E+ + L+ VE
Sbjct: 867 RLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEE 926
Query: 69 KSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEK 128
+ + L E + ++Q + E+LEE+ S ++ ++ T+ + K+E ++ L ++
Sbjct: 927 EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ 986
Query: 129 QLKHQVDHQKELLSCKSEELRV-MSERVQESMSSEMLALQIE--LTEMESMKTTLKEEVN 185
K + +K+LL + E ++E ++S S L + E +T++E +++
Sbjct: 987 NCK--LAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQ 1044
Query: 186 ELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQ 245
EL+ + +LE T+L Q+ L+ + E + + L+ A ++ Q + AL+
Sbjct: 1045 ELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK 1104
Query: 246 QALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQ 305
+ + S+ + L ++E RA+ + +KQ E+++ +K ++ L
Sbjct: 1105 KIRELESQISELQEDLESERASRNK-----------AEKQKRDLGEELEALKTELEDTLD 1153
Query: 306 MKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNT 365
+Q E + EQ+ +K L E + + M K S L +
Sbjct: 1154 STAAQQELRSKR------EQEVNILKKTLEE--EAKTHEAQIQEMRQKHSQAVEELAEQL 1205
Query: 366 YYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENM 425
T ++ L+ + +E+ +GEL+ +K L + + SE +
Sbjct: 1206 EQTKRVKANLEKAKQTLENERGELA-NEVKVLLQGKGD----------------SEHKRK 1248
Query: 426 KLRAKLDELKLKYEPEETVEVPVLKKRREV-LPVDITTA--KDACVNNSALGGEVYRLPP 482
K+ A+L EL++K+ E V + K ++ + +D T + +S L + L
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 483 QKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKN 519
Q ++TQ L++ N Q +S+ T + + KN
Sbjct: 1309 QLQDTQEL---LQEENRQ---KLSLSTKLKQVEDEKN 1339
Score = 74.3 bits (181), Expect = 3e-13
Identities = 102/504 (20%), Positives = 209/504 (41%), Gaps = 69/504 (13%)
Query: 4 DIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQ 63
D + + RL++ ++ L + Q + + Q + D+ E T++ Y +E+ +
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468
Query: 64 REVELKSRMLESLSCECEAIKQQQKMHLEKLEEQL------------------------S 99
E K SL+ E +QK LE+L +Q
Sbjct: 1469 AEAREKETKALSLARALEEA-MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSK 1527
Query: 100 RSHGQEVNELKTKIEKLKVEL---DEARLS------------EKQLKHQVDHQKE----- 139
R+ Q+V E+KT++E+L+ EL ++A+L E+ L+ + + +E
Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQL 1587
Query: 140 LLSCKSEELRVMSERVQESMS-SEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLI 198
+ + E + ER Q SM+ + L+++L ++E+ + + +E + +L+ +
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQM 1647
Query: 199 TNLMRQVDRLKEEKEE--------------REKEAVSYYNALEKARVANQDLQVQLDQAL 244
+ MR++D + +EE E E + L A A + Q + D+
Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707
Query: 245 QQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATL- 303
+ NS G A E RR +E ++ ++ + + + +++++ LQI +
Sbjct: 1708 DEI--ANSSGKGALALEEKRR--LEARIAQLEEELEEEQGNTELINDRLKKANLQIDQIN 1763
Query: 304 LQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNL--EKFKNLYDSMESKPSVDSGTL 361
+ ++ ++ E LE++N E+K L E+ K+K ++E+K + L
Sbjct: 1764 TDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQL 1823
Query: 362 EDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSE 421
++ T ++ K+++ ++ +R A +A +L +R QL E
Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKR--QLEE 1881
Query: 422 SENMKLRAKLDELKLKYEPEETVE 445
+E RA KL+ E E+ E
Sbjct: 1882 AEEEAQRANASRRKLQRELEDATE 1905
Score = 35.0 bits (79), Expect = 0.20
Identities = 35/178 (19%), Positives = 75/178 (42%), Gaps = 20/178 (11%)
Query: 266 AAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQ 325
A ++QL +MKV ++ Q R+ ++ LLQ+ + E +E L + +
Sbjct: 800 AKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVRE 859
Query: 326 KNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIEST 385
K ++ L E+ ++++S+ + L++ L + + L + +
Sbjct: 860 KQLAAENRLTEM----------ETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909
Query: 386 KGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPEET 443
K EL + D+E ++ E Q ++E K++ + EL+ + E EE+
Sbjct: 910 KQEL----------EEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 80.9 bits (198), Expect = 3e-15
Identities = 100/479 (20%), Positives = 211/479 (44%), Gaps = 61/479 (12%)
Query: 9 LRCRLKEAEEERLKAAQYGLQLVESQNELQ---NQLDKCRNEMMTMTESYEQEKYTLQRE 65
L+ + EE +K Q L + EL NQL+ + + + +E Y LQ+E
Sbjct: 830 LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889
Query: 66 VELKSRMLESLSCE----CEAIKQQQKM--------------------HLEKLEEQLSRS 101
+++K+ L+ S + ++QQQ+M + KLE++L +
Sbjct: 890 LKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQ 949
Query: 102 HGQEVNELKTKIEKLKVELDEARL----------SEKQLKHQVDHQKELLS-CKSEELRV 150
+L+ EK + EA L + +Q+K ++D KE LS + E + +
Sbjct: 950 RESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHL 1009
Query: 151 MSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKE 210
+ ++M L + ++ T+ E K T V EL+ Q E +T +++ + L+
Sbjct: 1010 KRDGENKAMHLSQLDMILDQTKTELEKKT--NAVKELEKLQHSTETELTEALQKREVLET 1067
Query: 211 EKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMER 270
E + E S L++ R Q Q+ L++ D ++ E+ED++ +
Sbjct: 1068 ELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKK----Q 1123
Query: 271 QLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQ-ERLLAMLEQKNGE 329
+L+ M Q+LK++N +++ ++ T+ + +G E EQ+ +L LE+ E
Sbjct: 1124 ELLEMD---QALKERNWELKQRAAQVTHLDMTIREHRG---EMEQKIIKLEGTLEKSELE 1177
Query: 330 IKHLLGEIRNL-EKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGE 388
+K +I +L +K +N + + K + + N L+ +++ + ++ +
Sbjct: 1178 LKECNKQIESLNDKLQNAKEQLREKEFI----MLQNEQEISQLKKEIERTQQRMKEMESV 1233
Query: 389 LSIQRMKALFESQRALDIERKLFANERCLQ-----LSESENMKLRAKLDELKLKYEPEE 442
+ Q + + A+D+ ++L +Q L+E+ + +++A+ + +L E E+
Sbjct: 1234 MKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELED 1292
Score = 73.9 bits (180), Expect = 4e-13
Identities = 105/541 (19%), Positives = 234/541 (43%), Gaps = 69/541 (12%)
Query: 28 LQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQ----REVELKSRMLES----LSCE 79
L+ + ++L++++ K ++++T+ + E++ + EL+ ++E S E
Sbjct: 679 LEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLE 738
Query: 80 CEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLKHQVDHQKE 139
+ +K+ L E+ + H ++ E++ +IE+L+ +L++ K+ + + ++
Sbjct: 739 TNINTEHEKICLAF--EKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ 796
Query: 140 LLSCKSEELRVMSERVQESMSSEMLALQIELTE-MESMKTTLKEEVNELQYRQEQLELLI 198
+ CK L + + ES EM ++ E +++++ + EE +++ LE+
Sbjct: 797 DIICKQHHLESLDRLLTES-KGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICK 855
Query: 199 TNLMRQVDRLKEEKEEREKE----AVSYYNALEKARVANQDLQ------VQLDQALQQAL 248
L+ +++L+ KE+ EK+ + Y ++ ++ N LQ V L LQQ
Sbjct: 856 EELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQ 915
Query: 249 DPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKG 308
+ E+ED + +E+Q+ ++ Q L+KQ + E++++M+
Sbjct: 916 QMLQQETIRNGELEDTQTKLEKQVSKLE---QELQKQRESSAEKLRKME----------- 961
Query: 309 SQTEFEQQERLLAMLEQKNGEIKHLLGEIR----NLEKFKNLYDSMESKPSVDSGTLEDN 364
E+ E + K ++ L G R ++++K ME + E+
Sbjct: 962 -----EKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENK 1016
Query: 365 TYYTDLLQMKLDNLNKEIE-STKGELSIQRMKALFESQRALDIERKLFANERCLQLSESE 423
+ L M LD E+E T +++++ E++ ++++ E LQ + E
Sbjct: 1017 AMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVL-ETELQNAHGE 1075
Query: 424 NMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQ 483
+L EL+ VL+K + L TT KD E+ +
Sbjct: 1076 LKSTLRQLQELR-----------DVLQKAQLSLEEKYTTIKDLTAELRECKMEI---EDK 1121
Query: 484 KEETQSCPNSLEDNNLQLEKSVSIYTPV-VSLSPHKNLPVDMQLKKEKKCVKLIGVPADA 542
K+E +L++ N +L++ + T + +++ H+ + E+K +KL G +
Sbjct: 1122 KQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRG-------EMEQKIIKLEGTLEKS 1174
Query: 543 E 543
E
Sbjct: 1175 E 1175
Score = 56.2 bits (134), Expect = 8e-08
Identities = 66/299 (22%), Positives = 131/299 (43%), Gaps = 33/299 (11%)
Query: 4 DIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESY-EQEKYTL 62
D+ LR E E+++ + + L E EL+ + + + MT+ E E E+ +
Sbjct: 1106 DLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKII 1165
Query: 63 QREVELKSRMLESLSC--ECEAIKQQQKMHLEKLEEQ--LSRSHGQEVNELKTKIEKLKV 118
+ E L+ LE C + E++ + + E+L E+ + + QE+++LK +IE+ +
Sbjct: 1166 KLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQ 1225
Query: 119 ELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQES-------------------- 158
+ E K+ + + Q + +ELR+ E+VQ S
Sbjct: 1226 RMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIER 1285
Query: 159 MSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELL----ITNLMRQVDRLKE---- 210
+SSE+ ++ E ++ L EE+ + R+ LE I L +V+ LKE
Sbjct: 1286 LSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHM 1345
Query: 211 EKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAME 269
E ++ + + + + + Q L QL++A + + ++L +V+DR +E
Sbjct: 1346 EMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIE 1404
Score = 50.4 bits (119), Expect = 5e-06
Identities = 43/160 (26%), Positives = 77/160 (48%), Gaps = 14/160 (8%)
Query: 6 ITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMT-MTESYEQEKYTLQR 64
+ N L EA ++++A Q ++ + S+ E QL K ++ + E K R
Sbjct: 1262 VQNSHTELAEARHQQVQA-QREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKV---R 1317
Query: 65 EVELKSRM---LESLSCECEAIKQQQKMHLEKLEEQLSR------SHGQEVNELKTKIEK 115
E L++RM ++ LS E E++K+ M + +E ++ S V +L ++EK
Sbjct: 1318 EAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEK 1377
Query: 116 LKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERV 155
K+EL+EA+ + L QV + E++ +E L E V
Sbjct: 1378 AKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417
Score = 42.0 bits (97), Expect = 0.002
Identities = 113/600 (18%), Positives = 242/600 (40%), Gaps = 79/600 (13%)
Query: 6 ITNLRCRLKEAEEERLKAAQYGL---QLVESQNELQNQLDKCRNEMMTMTESYEQEKYTL 62
+T R ++ E + +AA + Q++ + E+ Q DK E E + +K +
Sbjct: 266 LTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQ-DKVLREAENKLE--QSQKMVI 322
Query: 63 QREVELKSRMLESLSCECEAI---KQQQKMHLEKLE-----EQLSRSHGQEVNELKTKIE 114
++E L+ E + + + + KQ ++ ++ E E+LS++ Q ++ K+E
Sbjct: 323 EKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLE 382
Query: 115 KLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEME 174
K++ E + + + + +E EL ++ E+ L +++
Sbjct: 383 KVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEK---------------LRQLK 427
Query: 175 SMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEE-----REKEAVSYYNALEKA 229
KE++ + + ++ +T + + +L+ E E R+K ++ N K
Sbjct: 428 EENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKV 487
Query: 230 RVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFN 289
RVA Q+ ++ L QQ ++ +S+ E + ++R+L K Y S + + F+
Sbjct: 488 RVAAQNERLDL---CQQEIE-SSRVELRSLEKIISQLPLKRELFGFK-SYLSKYQMSSFS 542
Query: 290 REQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDS 349
++ + + A L + L L K EI+ L + + ++L
Sbjct: 543 NKEDRCIGCCEANKLVI----------SELRIKLAIKEAEIQKLHANLTANQLSQSLITC 592
Query: 350 MESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERK 409
+S+ S +LE +KL ++ ES K + + M +E +R +
Sbjct: 593 NDSQESSKLSSLETE-------PVKLGG-HQVAESVKDQ-NQHTMNKQYEKERQRLVTGI 643
Query: 410 LFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVN 469
+ +Q+ E+EN L+ + ++ + ++ +L+K ++ K
Sbjct: 644 EELRTKLIQI-EAENSDLKVNMAHRTSQF---QLIQEELLEKASNSSKLESEMTKKC--- 696
Query: 470 NSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKE 529
++ L Q EE +S+ N +LE+ + + ++L ++ + E
Sbjct: 697 -----SQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKI-----RSLETNINTEHE 746
Query: 530 KKCVKLIGVPADAEALSERSGNTPNSPRLAAE-SKLQTEVKEGKETSSKLEKE-TCKKLH 587
K C L A L + RL A+ K + KE ++T S L+++ CK+ H
Sbjct: 747 KIC--LAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHH 804
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 80.1 bits (196), Expect = 5e-15
Identities = 137/572 (23%), Positives = 252/572 (44%), Gaps = 92/572 (16%)
Query: 11 CRLKEAEEERLKAAQYGLQLVESQN---ELQNQLDKCRNEMMTMTESYEQEKYTLQREVE 67
C ++E +E + + ++ ++ + + EL+N+L C N ++ E+EK ++ + +
Sbjct: 230 CMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKL-ACSNALVL-----EREKALIKLQAD 283
Query: 68 LKS-----RMLESLSCECEAIK------QQQK----MHLEKLEEQLS--RSHGQEVNELK 110
S R S S ECE IK Q+QK +H+E+ + + R + V+E K
Sbjct: 284 FASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQK 343
Query: 111 TKIEK--LKVELDEARLSEKQLKH--QVDHQKELLSCKSEELRVMSERVQESMSSEMLAL 166
I K +K+ELD L E+ H + D +L C+ +EL++ Q+ + L
Sbjct: 344 RNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFL 403
Query: 167 QIELTEMESMKTTLKEEVNELQYRQEQLE---LLITNLMRQVDRLKEEKEER------EK 217
Q + ++ ++ L + N L ++++LE + T L V K++K + +
Sbjct: 404 QEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQA 463
Query: 218 EAVSYYNALEKAR-----VANQDLQVQLDQA-----LQQALDPNSKGNSLFAEVEDRRAA 267
E N+LE+A+ A Q Q + + A L+ KG L + D
Sbjct: 464 EVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQE 523
Query: 268 MERQLISMKVKYQSLKKQNVFNREQMQRMKLQIA-TLLQMKGSQTEFEQQERLLAMLEQK 326
++R+L ++ + +K+ NR++++ + L+++ L +++ S E Q ++ +A + K
Sbjct: 524 LQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMK 583
Query: 327 NGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTK 386
++ L++ K+ + + S+ ED T LL+ K + L K E K
Sbjct: 584 MNDM---------LDRIKHQH---REQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEK 631
Query: 387 ---GELSIQRM------KALFESQRALDIERK-LFANERC--LQLSESEN------MKLR 428
GEL R K L E+ R L+ E + L A +C QL S N ++
Sbjct: 632 LMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQ 691
Query: 429 AKLDELKLKYEPEETVEVPV---LKKRREVLPVDIT-TAKDACVNNSA-----LGGEVYR 479
E+ L+ E +++ + L+K + L IT A DA SA L + +
Sbjct: 692 DLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEK 751
Query: 480 LPPQKEETQSCPNSL---EDNNLQLEKSVSIY 508
L ET+S SL ++ QLE+ + Y
Sbjct: 752 LNHVTSETKSLQQSLTQTQEKKAQLEEEIIAY 783
Score = 79.0 bits (193), Expect = 1e-14
Identities = 98/478 (20%), Positives = 214/478 (44%), Gaps = 53/478 (11%)
Query: 6 ITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQRE 65
IT L+CRL+E + L+ E+Q +L + DK E M + E++ +Q
Sbjct: 375 ITILQCRLQELQ----------LEFTETQ-KLTLKKDKFLQEKDEMLQELEKKLTQVQNS 423
Query: 66 VELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARL 125
+ K + LE C ++ K E + +S E L+ +++KLK L+EA+
Sbjct: 424 LLKKEKELEKQQCMATELEMTVK------EAKQDKSKEAECKALQAEVQKLKNSLEEAKQ 477
Query: 126 SEKQLKHQVDHQKE---LLSCKSEELRVMSER---VQESMSSEMLALQIELTEMESMKTT 179
E+ Q KE L C E+ + ++ + + + + LQ EL ++ +
Sbjct: 478 QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSM 537
Query: 180 LKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREK----EAVSYYNALEKARVANQD 235
++E + R E+L L ++ +R+++ +EK + +K + + + L++ + +++
Sbjct: 538 AEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHRE 597
Query: 236 ---LQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISM----KVKYQSLKKQNVF 288
++ +L++ LQ+A + ++ ME +L ++ K K ++LK+ +
Sbjct: 598 QGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRK 657
Query: 289 NREQMQRMKLQI-ATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEI-----RNLEK 342
E+ + ++ ++ Q++ S ++ ++++ L ++ K L + + L+K
Sbjct: 658 LEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQK 717
Query: 343 FKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQR 402
K+ + +K + D+ + + DL Q L+ LN TK S+Q+ + ++
Sbjct: 718 EKHYLQTTITKEAYDALSRKSAACQDDLTQ-ALEKLNHVTSETK---SLQQSLTQTQEKK 773
Query: 403 ALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDI 460
A +E ++ A E ++ +E KLR + E +EV K+ E + +
Sbjct: 774 A-QLEEEIIAYEERMKKLNTELRKLRG--------FHQESELEVHAFDKKLEEMSCQV 822
Score = 63.9 bits (154), Expect = 4e-10
Identities = 105/470 (22%), Positives = 206/470 (43%), Gaps = 57/470 (12%)
Query: 11 CRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEM-MTMTESYEQEKYTLQREVELK 69
C L++ + + K Q ++ ELQ +L + E M E K + +EL
Sbjct: 498 CHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELS 557
Query: 70 S--RMLESLSCECEAIKQ---QQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEAR 124
R LE+ E +++ +Q M + + +++ H +E +K K+E+ +L EA
Sbjct: 558 EALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQH-REQGSIKCKLEE---DLQEAT 613
Query: 125 --LSEK--QLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIE----LTEMESM 176
L +K QLK +H+K L+ + E LR ++ +++ L+ E E++
Sbjct: 614 KLLEDKREQLKKSKEHEK-LMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCC 672
Query: 177 KTTLKEEVNELQYRQEQLELL----------ITNLMRQVDR-LKEEKEERE----KEAVS 221
T L+ +N+ Q+ ++ L + +L Q+D+ L++EK + KEA
Sbjct: 673 STQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEA-- 730
Query: 222 YYNALEKARVANQDLQVQLDQALQQALDPNSKGNSL---FAEVEDRRAAMERQLIS---- 274
Y+AL + A QD L QAL++ S+ SL + ++++A +E ++I+
Sbjct: 731 -YDALSRKSAACQD---DLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEER 786
Query: 275 MKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERL-LAMLEQKNGEIKHL 333
MK L+K F++E + L +M ++++Q + L ML K +++
Sbjct: 787 MKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREF 846
Query: 334 LGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQR 393
E+ L++ NL + + + ++ +T L D + +E + +
Sbjct: 847 QEEMAALKE--NLLEDDKEPCCLPQWSVPKDTCR---LYRGNDQIMTNLEQWAKQQKVAN 901
Query: 394 MKALFESQRALDIERKLFANERCLQLS----ESENMKLRAKLDELKLKYE 439
K + + + KL + L + EN KL+ +++E K+K E
Sbjct: 902 EKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAE 951
Score = 38.5 bits (88), Expect = 0.018
Identities = 96/526 (18%), Positives = 208/526 (39%), Gaps = 75/526 (14%)
Query: 104 QEVNELKTKIEKLKVELDEAR-LSEKQLKHQVDHQ---KELLSCKSEELRVMSERVQESM 159
+EV+ L +K+ L++++ + ++Q K D+Q +E ++ ++ + + +ES
Sbjct: 10 REVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESE 69
Query: 160 SSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEE----- 214
+ Q L +++ +K L EL++ E+L+ +L + L+++ +
Sbjct: 70 VEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLH 129
Query: 215 -----REKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAME 269
+E E + Y E+ N++ +L A +Q A D+ A++E
Sbjct: 130 HHCKLKEDEVILYE---EEMGNHNENTGEKLHLAQEQ-----------LALAGDKIASLE 175
Query: 270 RQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLL----QMKGSQT------------EF 313
R L + KYQS Q++ ++ ++ ++ + KG + E
Sbjct: 176 RSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEH 235
Query: 314 EQQERLLAMLEQKNGEIKHLLGEIRN---------LEKFKNLYDSMESKPSVDSGTLEDN 364
++ ++ L+ + QK + L+ E+RN LE+ K L K D +
Sbjct: 236 QETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALI-----KLQADFASCTAT 290
Query: 365 TYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESEN 424
Y + +++ K ++ + + Q + D+ +L A + +
Sbjct: 291 HRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDM 350
Query: 425 MKLRAKLDELKLK---YEPEETVEVPVLKKRREVLPVDIT-TAKDACVNNSALGGEVYRL 480
MKL L L+ + + + ++ +L+ R + L ++ T T K + L + L
Sbjct: 351 MKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEML 410
Query: 481 PPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPA 540
+++ NSL +LEK + T + + V + + K + + A
Sbjct: 411 QELEKKLTQVQNSLLKKEKELEKQQCMATEL-------EMTVKEAKQDKSKEAECKALQA 463
Query: 541 DAEALSERSGNTPNSPRLAAESKLQTEVKEG------KETSSKLEK 580
+ + L RLAA+ Q + + ++T KL+K
Sbjct: 464 EVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQK 509
Score = 35.8 bits (81), Expect = 0.12
Identities = 56/249 (22%), Positives = 105/249 (42%), Gaps = 38/249 (15%)
Query: 34 QNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEK 93
Q++L L+K N + + T+S +Q +L + E K+++ E E I +++M +K
Sbjct: 742 QDDLTQALEKL-NHVTSETKSLQQ---SLTQTQEKKAQLEE------EIIAYEERM--KK 789
Query: 94 LEEQLSRSHG-QEVNELKTKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMS 152
L +L + G + +EL+ K+E ++ + Q +HQ D ++L+ K E+LR
Sbjct: 790 LNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQND--LKMLAAKEEQLREFQ 847
Query: 153 ERVQESMSSEMLALQIELTEMESMKTTLKE-----EVNELQYRQEQLELLITNLMRQVDR 207
E EM AL+ L E + L + + L +Q+ + +Q
Sbjct: 848 E--------EMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKV 899
Query: 208 LKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAA 267
E+ + +E V Y L + + V L Q + L E+E+++
Sbjct: 900 ANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQ----------ENKKLKKEIEEKKMK 949
Query: 268 MERQLISMK 276
E + K
Sbjct: 950 AENTRLCTK 958
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 79.7 bits (195), Expect = 7e-15
Identities = 143/603 (23%), Positives = 262/603 (43%), Gaps = 93/603 (15%)
Query: 9 LRCRLKEAEEERLKAAQYGLQL---VESQNELQNQLDKCRNEMMTMTESYEQEKYTLQR- 64
LR RL++ ER A + L V+S ++ + L K R E+ E EQE + L+R
Sbjct: 433 LRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRV 492
Query: 65 EVELKSRMLESLSCECEAIKQQQKMHL-----EKLEEQLSRSHGQEVNELKTKIEKLKVE 119
VEL+ L+ S + + +QQ+++HL E+L+E L ++ L I L+
Sbjct: 493 NVELQ---LQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELIT-LREA 548
Query: 120 LDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTT 179
L+ + L + ELL + E+ R ++S++ E+ S + T
Sbjct: 549 LESSHL-----------EGELLRQEQTEVTAALARAEQSIA-----------ELSSSENT 586
Query: 180 LKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQ 239
LK EV +L+ +L L L L ++ + E+E S + +E A A LQV
Sbjct: 587 LKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
Query: 240 LDQA--LQQAL-DPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRM 296
L +A ++AL + N+ + + E+ A ++ L ++ + + ++K+ +R Q +
Sbjct: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAA 706
Query: 297 KLQIATLLQMKGSQTEFEQQERLLA-MLEQKNGEIKHLLG-EIRNLEKFKNLYDSMESKP 354
Q+ L Q E ++QE +LA +++K ++ E+R ++ D E
Sbjct: 707 TTQLEQLHQ------EAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQ 760
Query: 355 SVDSGTLEDNTYYTDLLQMKL---DNLNKEIESTKGELSIQ-----RMKALFESQ----- 401
+ S +LL+ L N IE TKG+L +Q + K + + +
Sbjct: 761 GLSSA--------KELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLK 812
Query: 402 RALDIERKLFANER---CLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPV 458
LD ER ER QL+++E + + L++ K +E E +K R
Sbjct: 813 LELDTERSQAEQERDAAARQLAQAE-QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQ 871
Query: 459 DITTAKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHK 518
++ A ++ + + E+ RL Q+ E ++ E+ Q E ++
Sbjct: 872 ELAKALES-LEREKMELEM-RLKEQQTEMEAIQAQREEERTQAESAL------------- 916
Query: 519 NLPVDMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKL 578
MQL+ EK+ V L+ + E + + RL + K+Q ++KE +ET+ L
Sbjct: 917 ---CQMQLETEKERVSLLETLLQTQ--KELADASQQLERLRQDMKVQ-KLKE-QETTGIL 969
Query: 579 EKE 581
+ +
Sbjct: 970 QTQ 972
Score = 75.5 bits (184), Expect = 1e-13
Identities = 96/465 (20%), Positives = 209/465 (44%), Gaps = 41/465 (8%)
Query: 7 TNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREV 66
T+L +L++AEE + + E + E+Q +L + R++ T EQ +R+
Sbjct: 662 THLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQE 721
Query: 67 ELKSRMLE----------SLSCECEAIKQQQKMHLEKLE-----EQLSRSHGQEVNELKT 111
E+ +R ++ +L +A+++ ++ E+L+ ++L S E + +
Sbjct: 722 EVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNS 781
Query: 112 KIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIE-L 170
IE K +L+ + Q K + + L + + R +E+ +++ + ++ + E
Sbjct: 782 VIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK 841
Query: 171 TEMESMKTTLKEEVNELQYR-QEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKA 229
T +E K ++EVN+L+ + +++ L + ++ L+ EK E E +E
Sbjct: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901
Query: 230 RVANQDLQVQLDQAL-QQALDPNSKGNSLF-------AEVEDRRAAMERQLISMKVKYQS 281
+ ++ + Q + AL Q L+ + SL E+ D +ER MKV Q
Sbjct: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV--QK 959
Query: 282 LKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLE 341
LK+Q Q Q LQ A Q + + + ++ L A+ E+ + ++ + + +E
Sbjct: 960 LKEQETTGILQTQ---LQEA---QRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVE 1013
Query: 342 KFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRM---KALF 398
K+ + + + +++ T + + + KE+E K L++ M + L
Sbjct: 1014 DLKSQLVAQDDSQRLVEQEVQEKLRET----QEYNRIQKELEREKASLTLSLMEKEQRLL 1069
Query: 399 ESQRALDI-ERKLFANERCLQLSESENMKLRAKLDELKLKYEPEE 442
Q A I +++L A + +Q ++ E +L A+++ L+ + + +E
Sbjct: 1070 VLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKE 1114
Score = 70.9 bits (172), Expect = 3e-12
Identities = 101/443 (22%), Positives = 202/443 (45%), Gaps = 41/443 (9%)
Query: 9 LRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVEL 68
L+ + +E E ER +A Q ++ Q EL+ K E + + E+ + EVE
Sbjct: 1388 LKLKNEEVESERERA-----QALQEQGELKVAQGKALQENLALLTQTLAER---EEEVET 1439
Query: 69 KSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEK 128
++ L E ++ QK LE L L + + QEV+ + +I+ EL++ R +
Sbjct: 1440 LRGQIQEL----EKQREMQKAALELLSLDLKKRN-QEVDLQQEQIQ----ELEKCRSVLE 1490
Query: 129 QLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQ 188
L V +++ L+ + E++R + E+ +E+ + + +EL + + M + + +V +L+
Sbjct: 1491 HLPMAVQEREQKLTVQREQIREL-EKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLK 1549
Query: 189 YRQEQLELLITNLMR-------QVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLD 241
+ LE L L Q +KE + +RE + V+ + +Q+LQ Q
Sbjct: 1550 KQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQ-- 1607
Query: 242 QALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIA 301
Q D S L E+++R ++++ S + + + L++Q + ++R ++
Sbjct: 1608 --SSQIHDLESHSTVLARELQER----DQEVKSQREQIEELQRQKEHLTQDLERRDQEL- 1660
Query: 302 TLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEI-RNLEKFKNLYDSMESKPSVDSGT 360
+LQ + Q +Q+ R +LE+ +IK L E R L + L M+ + G
Sbjct: 1661 -MLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQL---MQERAEEGKGP 1716
Query: 361 LEDNTYYTDLLQMKLDNLNKEIESTKGEL-SIQRMKALFESQRALDIERKLFANERCLQL 419
+ + +++ L + KE+E + + +Q +K E Q+ + RK+ L
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLE-QQLQGLHRKVGETSLLLSQ 1775
Query: 420 SESENMKLRAKLDELKLKYEPEE 442
E E + L+ +L E + + E +E
Sbjct: 1776 REQEIVVLQQQLQEAREQGELKE 1798
Score = 68.2 bits (165), Expect = 2e-11
Identities = 112/528 (21%), Positives = 216/528 (40%), Gaps = 66/528 (12%)
Query: 15 EAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLE 74
+ E +R+ L L E ELQ Q + + E L RE++ + + ++
Sbjct: 1582 QRETQRVALTHLTLDLEERSQELQAQSSQIHD--------LESHSTVLARELQERDQEVK 1633
Query: 75 SLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLKHQV 134
S +++Q L++ +E L++ + EL + E+++V D+ K L+ +
Sbjct: 1634 S--------QREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDL 1685
Query: 135 DHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLK----------EEV 184
+ K L + EL + +QE + + +E MK L+ E +
Sbjct: 1686 EQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHI 1745
Query: 185 NELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKAR----VANQDLQVQL 240
+ELQ ++QLE + L R+V +RE+E V L++AR + Q LQ QL
Sbjct: 1746 HELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL 1805
Query: 241 DQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNRE---QMQRMK 297
D+A + + + +L E + + ER +L++ ++ +E ++Q K
Sbjct: 1806 DEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHK 1865
Query: 298 LQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEK----FKNLYDSMESK 353
Q L + E + R + LE+ G+++ E R EK + +
Sbjct: 1866 EQARRL------EEELAVEGRRVQALEEVLGDLR---AESREQEKALLALQQQCAEQAQE 1916
Query: 354 PSVDSGTLEDNTYYTDLL----QMKLDNLNKEIESTKGELSIQR------MKALFESQRA 403
V++ L+D+ + +L+ L E +S++ + R +AL ++ A
Sbjct: 1917 HEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAA 1976
Query: 404 LD-IERKLFANERCLQLSESENMKLRAKLDELKL-KYEPEETVEVPVLKKRREVLPVDIT 461
L E+ L + E+ L+A LD + + EE + + + E+ D+
Sbjct: 1977 LQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI----QEGEIQDQDLR 2032
Query: 462 TAKDACVNNSALGGEVYRLPPQKEETQSCPNSL----EDNNLQLEKSV 505
+D AL L Q+E Q SL ++N +Q ++++
Sbjct: 2033 YQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNL 2080
Score = 61.6 bits (148), Expect = 2e-09
Identities = 84/346 (24%), Positives = 157/346 (45%), Gaps = 53/346 (15%)
Query: 15 EAEEERLKAAQYGLQLVESQNE----LQNQLDKCRNEMMTMTESYEQEKYTLQREV---- 66
+AE+ER AA+ QL +++ E L+ Q E+ + E +E+E+ Q+E+
Sbjct: 821 QAEQERDAAAR---QLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
Query: 67 --------ELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKV 118
EL+ R+ E + E EAI+ Q++ + E L +++ + EK +V
Sbjct: 878 ESLEREKMELEMRLKEQQT-EMEAIQAQREEERTQAESALC--------QMQLETEKERV 928
Query: 119 ELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKT 178
L E L QKEL S++L ER+++ M + L Q E T + ++T
Sbjct: 929 SLLETLLQT---------QKELADA-SQQL----ERLRQDMKVQKLKEQ-ETTGI--LQT 971
Query: 179 TLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQV 238
L+E EL+ Q + L + L ++K + +K+ L+ VA D Q
Sbjct: 972 QLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQV----EDLKSQLVAQDDSQR 1027
Query: 239 QLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKL 298
++Q +Q+ L + N + E+E +A++ L+ + + L++ + ++++ ++
Sbjct: 1028 LVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR- 1086
Query: 299 QIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFK 344
+ + +G Q E Q LL E K E L E + LE+ +
Sbjct: 1087 --QDMQEAQGEQKELSAQMELLRQ-EVKEKEADFLAQEAQLLEELE 1129
Score = 55.8 bits (133), Expect = 1e-07
Identities = 112/549 (20%), Positives = 232/549 (42%), Gaps = 86/549 (15%)
Query: 14 KEAEEER-------LKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREV 66
KE E E+ ++ Q L L E+ + Q +L R +M EQ++ + Q E+
Sbjct: 1048 KELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQG--EQKELSAQMEL 1105
Query: 67 ---ELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRS-HGQEVN--ELKTKIEKLKVEL 120
E+K + + L+ E + +++ + H+ E+QL S QE +L+ ++ + +L
Sbjct: 1106 LRQEVKEKEADFLAQEAQLLEELEASHIT--EQQLRASLWAQEAKAAQLQLRLRSTESQL 1163
Query: 121 DEARLSEKQLKHQVDHQKELLS------------CKSE-ELR------------------ 149
EA +E+Q +Q Q +L S C+S EL
Sbjct: 1164 -EALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNG 1222
Query: 150 ---------VMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYR-------QEQ 193
+++ E+++S + L +L + + + L+++V +L+ R + Q
Sbjct: 1223 ARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQ 1282
Query: 194 LELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSK 253
+ + +L RQ+ + +EEK + E + S + L + LQ +L +A Q ++ +
Sbjct: 1283 VHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGE 1342
Query: 254 GNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEF 313
L A E+ A +E L + V+ ++ E ++ + + L++K + E
Sbjct: 1343 RELLQAAKENLTAQVE-HLQAAVVEARAQASAAGILEEDLRTAR----SALKLKNEEVES 1397
Query: 314 EQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQM 373
E +ER A+ EQ GE+K G+ +++ ++ + TL + + L+
Sbjct: 1398 E-RERAQALQEQ--GELKVAQGK------------ALQENLALLTQTLAEREEEVETLRG 1442
Query: 374 KLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDE 433
++ L K+ E K L + + +Q + ++ E+C + E M ++ + +
Sbjct: 1443 QIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQK 1502
Query: 434 LKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQKEETQSCPNS 493
L ++ E +E + +R VL + + + G+V L Q +
Sbjct: 1503 LTVQREQIRELEKD-RETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALE 1561
Query: 494 LEDNNLQLE 502
LE+N+ ++E
Sbjct: 1562 LEENHHKME 1570
Score = 49.7 bits (117), Expect = 8e-06
Identities = 81/435 (18%), Positives = 181/435 (41%), Gaps = 39/435 (8%)
Query: 4 DIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQ 63
+++ +LR +E E+ L Q + + L + + + +QE L+
Sbjct: 1887 EVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR 1946
Query: 64 REVELKSRMLESLSCECEAIK----------QQQKMHLEKLEEQLSRSHGQEVNELKTKI 113
E + E+ EA++ Q ++ HL + + +LSRS L+ +
Sbjct: 1947 AESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLE-QAELSRSLEASTATLQASL 2005
Query: 114 EKLK---------VELDEARLSEKQLKHQVDHQK--ELLSCKSEELRVMSERVQESMSSE 162
+ + + + E + ++ L++Q D Q+ + L+ + EELR ER E + +
Sbjct: 2006 DACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQER--EQLLEK 2063
Query: 163 MLALQIE---LTEMESM-KTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKE 218
LA +++ + E +++ + +EE+ L +L+L + +++ L+E ++ E
Sbjct: 2064 SLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLE 2123
Query: 219 AVSY---YNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISM 275
A+ + + +E+ + L+ +L + L++ + + E ++ + L
Sbjct: 2124 ALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQT 2183
Query: 276 KVKYQSLKKQNVFNREQM-----QRMKLQIATLLQMKGSQTEFEQQERLLAMLE-QKNGE 329
K SL++ +F + + ++ +LQ L + + E + E GE
Sbjct: 2184 KASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGE 2243
Query: 330 IKHLLGEIRNLEKFKNLYDSMESKP-SVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGE 388
LGE+ +E + D ME + L+ ++ + +L N ++ ST +
Sbjct: 2244 QGVQLGEVSGVEA-EPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ 2302
Query: 389 LSIQRMKALFESQRA 403
+ +R K E+ RA
Sbjct: 2303 VERERRKLKREAMRA 2317
Score = 49.3 bits (116), Expect = 1e-05
Identities = 101/459 (22%), Positives = 193/459 (42%), Gaps = 66/459 (14%)
Query: 9 LRCRLKEAEEERLKAAQYGLQLVESQNELQN--------QLDKCRNEMMTMTESYEQEKY 60
L + +E E+E + +Q +QL +SQ +L+ +L + E YE+
Sbjct: 249 LLAKTQELEKEAHERSQELIQL-KSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIK 307
Query: 61 TLQREVE-LKSRMLESLSCECEAIK--QQQKMHLEKLEEQLSRSHGQEVNEL-KTKIEKL 116
L+ VE L++ E + E + Q++K+ L+++ + +++ +E + + + +
Sbjct: 308 ALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHEN 367
Query: 117 KVELDEARLSEKQLKHQVDHQKELLSCKS---------EELRVMSERVQESMSSEMLALQ 167
+ELD + S Q +Q D K L +S ++LR QE+++ LQ
Sbjct: 368 SLELDSSIFS--QFDYQ-DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVN----LLQ 420
Query: 168 IELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALE 227
+ + E L++ + +L ++ L +L +VD L +E+E L+
Sbjct: 421 QQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERE-----------LLQ 469
Query: 228 KARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNV 287
KAR ++L+ QL+ Q+A RR +E QL + Q ++Q
Sbjct: 470 KAR---EELRQQLEVLEQEAW-------------RLRRVNVELQLQGDSAQGQKEEQQEE 513
Query: 288 FNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLY 347
+ +R +LQ L+ ++ Q+ E L+ + E E HL GE+ E+ +
Sbjct: 514 LHLAVRERERLQ-EMLMGLEAKQS--ESLSELITLREAL--ESSHLEGELLRQEQTEVTA 568
Query: 348 DSMESKPSVDSGTLEDNTYYTDLLQM-----KLDNLNKEIESTKGELSIQRMKALFESQR 402
++ S+ + +NT T++ + KL LN+ + K L+ Q ++ E+Q
Sbjct: 569 ALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQS 628
Query: 403 ALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPE 441
LQ+ +E K R L E E +
Sbjct: 629 VCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQ 667
Score = 43.1 bits (100), Expect = 7e-04
Identities = 86/411 (20%), Positives = 171/411 (41%), Gaps = 72/411 (17%)
Query: 73 LESLSCECEAIKQ---QQKMHLEKLEEQLSRSHGQEVNE-LKTKIEKLKVELDEAR--LS 126
LE CE++ + Q ++H+EK + VN+ L+ +EKL V+ AR L
Sbjct: 103 LEEEQQRCESLAEVNTQLRLHMEKADV---------VNKALREDVEKLTVDWSRARDELM 153
Query: 127 EKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNE 186
K+ + Q++ + K E R++S + E++ + EM K+ ++ E
Sbjct: 154 RKESQWQMEQEFFKGYLKGEHGRLLS------LWREVVTFRRHFLEM---KSATDRDLME 204
Query: 187 LQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVA-----NQDLQVQLD 241
L+ +L +L+ RL + RE + E A++ Q+L+ +
Sbjct: 205 LKAEHVRLS---GSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAH 261
Query: 242 QALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIA 301
+ Q+ + S+G+ AE++DR + L + + + +K RE ++ ++
Sbjct: 262 ERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHT 321
Query: 302 TLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTL 361
L++ + S + Q+E+L L+Q +I ++ +E ++ G+
Sbjct: 322 ELMEHEASLSRNAQEEKL--SLQQVIKDITQVM---------------VEEGDNIAQGSG 364
Query: 362 EDNTYYTD---LLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQ 418
+N+ D Q + +K + + L+ +R Q D+ ++L + +
Sbjct: 365 HENSLELDSSIFSQFDYQDADKALTLVRSVLTRRR-------QAVQDLRQQLAGCQEAVN 417
Query: 419 LS-------ESENMKLRAKLDELKLKYE--PEETV----EVPVLKKRREVL 456
L E E LR +L +L + + +TV EV L K RE+L
Sbjct: 418 LLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL 468
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 79.7 bits (195), Expect = 7e-15
Identities = 154/663 (23%), Positives = 273/663 (41%), Gaps = 125/663 (18%)
Query: 19 ERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMT--ESYEQEKYTLQREVELKSRMLESL 76
ER + + L +E +NEL + K N +T E+ EQE L+RE + L+S
Sbjct: 625 ERAEELENELHHLEKENELLQK--KITNLKITCEKIEALEQENSELERENRKLKKTLDSF 682
Query: 77 SCECEAIKQQQKMHLEKLEEQLS-RSHGQEVNELKTKIEKLKVELDEARLSEKQLKHQVD 135
++ +K + + EE L R + + + K+ +L++E E ++QLK ++
Sbjct: 683 KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE 742
Query: 136 HQK------ELLSCKSEELRVMSERVQ---ESMSSEMLALQIELTEMESMKTTLKEEVNE 186
K E L + L + ++R+Q E+ + ++ L+ EL ++E TL++ + E
Sbjct: 743 LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE 802
Query: 187 LQY---RQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQA 243
L+ R EQLE +L ++ +L+++K++ EKE N+ L+ Q +
Sbjct: 803 LKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE--------------NKRLRQQA-EI 847
Query: 244 LQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATL 303
L+ N N +E + +++ K LK+ N+E ++R + I TL
Sbjct: 848 KDTTLEEN---NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
Query: 304 LQMKGSQT------------------EFEQ----QERLLAMLEQKNGEIKHLLGEIRNLE 341
+ ++ E E+ +ERLL EQ + ++ L E +
Sbjct: 905 VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD-EQSTDDSRYKLLESKLES 963
Query: 342 KFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRM------- 394
K + E K + LE++T Y L+ +L + K E+ K +RM
Sbjct: 964 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1023
Query: 395 -----KALFESQRA----LDIERKLFANERCLQLSESENMKLRAKLDELKLKYE------ 439
K ESQ L ++ +L ER ++E L+ +L +L+ +
Sbjct: 1024 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1083
Query: 440 ---PEETVEV----PVLKKRREVLPVDITTAK-----------DACVNNSALGGEVYRLP 481
+TV + L+ + L V+ +T + S+L E +
Sbjct: 1084 LALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1143
Query: 482 PQKEETQSCPNSL----EDNNLQLEKSVSIYTPVVS-----LSPHKNLPVD--------M 524
++E+ +S +SL E L E+ S Y ++S S HKNL V+
Sbjct: 1144 KEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1203
Query: 525 QLKKEK----KCVKLIGVPADAEALSERSGNTPNSPRLAAE-SKLQTEVKEGKETSSKLE 579
QL K+K K++ V + L ++ T +AAE KL E T S+L
Sbjct: 1204 QLLKQKGQLEDLEKMLKVEQEKMLLENKNHET-----VAAEYKKLCGENDRLNHTYSQLL 1258
Query: 580 KET 582
KET
Sbjct: 1259 KET 1261
Score = 78.2 bits (191), Expect = 2e-14
Identities = 113/487 (23%), Positives = 206/487 (42%), Gaps = 60/487 (12%)
Query: 4 DIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQ 63
DI T + R ++ E+LK Q L + +EL+ ++ + ++ +S + +Y L
Sbjct: 900 DIKTLVTLR-EDLVSEKLKTQQMNNDLEKLTHELE-KIGLNKERLLHDEQSTDDSRYKLL 957
Query: 64 REVELKSRMLESLSCECEAIKQQQKMHLE-KLEEQLSRSHG--QEVNELKTKIEKLKVEL 120
E +L+S + +SL IK+++ LE +LEE + + QE+ +K E LK
Sbjct: 958 -ESKLESTLKKSLE-----IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011
Query: 121 DEARLSE----------KQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIEL 170
DE R+ + K + + +ELL K + V ER ++ +E AL+ +L
Sbjct: 1012 DEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV--ERNNATLQAEKQALKTQL 1069
Query: 171 TEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKAR 230
++E+ L+ ++ LQ + L+ T L Q +L+ E ++ S N +
Sbjct: 1070 KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL 1129
Query: 231 VANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLI---SMKVKYQSLKKQNV 287
+ L+ + + +++ D S +SL + E ERQ S+ K+ +LK +
Sbjct: 1130 IQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHK 1189
Query: 288 FNREQMQRMKLQIATLLQMKGSQTEFE-----QQERLLAMLEQKN-----GEIKHLLGEI 337
+ + ++ + LL+ KG + E +QE++L LE KN E K L GE
Sbjct: 1190 NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML--LENKNHETVAAEYKKLCGEN 1247
Query: 338 ---------------------RNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLD 376
+NL+ N +++ + L++ D+ KL+
Sbjct: 1248 DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1307
Query: 377 NLNKEIESTKGELSIQRMKALFESQRALDIERKLF-ANERCLQLSESENMKLRAKLDELK 435
N + + KG L + L + Q + R L N L E + KL+EL+
Sbjct: 1308 NQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELR 1367
Query: 436 LKYEPEE 442
+ E E
Sbjct: 1368 RQKEKLE 1374
Score = 68.2 bits (165), Expect = 2e-11
Identities = 111/536 (20%), Positives = 232/536 (43%), Gaps = 103/536 (19%)
Query: 19 ERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSC 78
E LK + L+ +E +N+ L++ +++ + E+E L+++ E+K LE +
Sbjct: 801 EELKISSKRLEQLEKENK---SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV 857
Query: 79 ECEAIKQQQK----------------MHLEKLEEQLSR-----------------SHGQE 105
+ ++++ K LEK ++L + S +
Sbjct: 858 KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917
Query: 106 VNELKTKIEKLKVELDEARLSEKQLKHQV----DHQKELLSCKSEELRVMSERVQESMSS 161
++ +EKL EL++ L++++L H D + +LL K E S ++E +
Sbjct: 918 TQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIA 977
Query: 162 EMLALQIELT----EMESMKTTLKEEVNELQYRQEQLELLITN--LMRQVDRLKEEKEER 215
+ A E T ++ T+K+ L+ RQ++ ++ ++ + + ++ + E +E
Sbjct: 978 ALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQET 1037
Query: 216 EKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISM 275
+E + + L + N LQ + Q ++ N+L A++ A++RQ +S+
Sbjct: 1038 TRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI----LALQRQTVSL 1093
Query: 276 KVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLL---AMLEQKNGEIKH 332
+ + +L+ QN KLQ+ S + Q +LL + LE +N +
Sbjct: 1094 QEQNTTLQTQNA---------KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV-- 1142
Query: 333 LLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQ 392
I+ E K+LYDS+ ++D+ KL+ L+ E ++++ E I
Sbjct: 1143 ----IKEREDLKSLYDSL----------IKDHE--------KLELLH-ERQASEYESLIS 1179
Query: 393 RMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELK--LKYEPEETVEVPVLK 450
+ L + + L++E R L+ ++ +K + +L++L+ LK E E+ + +
Sbjct: 1180 KHGTLKSAHKNLEVE------HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML---LEN 1230
Query: 451 KRREVLPVDITTAKDACVNNSALGGEVYRLPPQKEETQSCPNSLED--NNLQLEKS 504
K E + + K C N L +L + E Q+ +L+ NN +LE++
Sbjct: 1231 KNHETVAAEY---KKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1283
Score = 68.2 bits (165), Expect = 2e-11
Identities = 111/475 (23%), Positives = 194/475 (40%), Gaps = 68/475 (14%)
Query: 12 RLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSR 71
RLKE E+E + + +++ L+ L + + M E+ + L++ K R
Sbjct: 882 RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER 941
Query: 72 MLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLK 131
+L E + K+ KLE L +S E+ E KI L+ L+E+ +QL+
Sbjct: 942 LLHD---EQSTDDSRYKLLESKLESTLKKS--LEIKE--EKIAALEARLEESTNYNQQLR 994
Query: 132 HQVDHQK---ELLSCKSEELRVMS------------ERVQESMSSEMLALQIELTEMESM 176
++ K E L + +E R++ ER + + E+L ++ L E+E
Sbjct: 995 QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERN 1054
Query: 177 KTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDL 236
TL+ E L+ + +QLE NL Q+ L+ + +++ + K +V N L
Sbjct: 1055 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL 1114
Query: 237 QVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSL----KKQNVFNREQ 292
Q + Q + +SL E E+ ER+ +K Y SL +K + + Q
Sbjct: 1115 NSQSTSLMNQNAQLLIQQSSL--ENENESVIKERE--DLKSLYDSLIKDHEKLELLHERQ 1170
Query: 293 MQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYD---- 348
+ I+ +K + E + R LE + ++ G++ +LEK +
Sbjct: 1171 ASEYESLISKHGTLKSAHKNLEVEHR---DLEDRYNQLLKQKGQLEDLEKMLKVEQEKML 1227
Query: 349 ---------SMESKPSVDSGTLEDNTY-----YTDLLQMKLDNL-----NKEIESTKGEL 389
+ E K ++TY T++LQ NL N ++E T+ E
Sbjct: 1228 LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA 1287
Query: 390 SIQRMKALFESQRALDI-ERKLFANERCLQLS------ESENMKLRAKLDELKLK 437
++K E + LDI KL N +C LS E EN L ++ L L+
Sbjct: 1288 EFSKLK---EQYQQLDITSTKL--NNQCELLSQLKGNLEEENRHLLDQIQTLMLQ 1337
Score = 61.2 bits (147), Expect = 3e-09
Identities = 130/659 (19%), Positives = 274/659 (41%), Gaps = 94/659 (14%)
Query: 9 LRCRLKEAEEERLKAAQYGLQLVES---QNELQNQLDKCRNEMMTMTESYEQEKYTLQRE 65
++C+ KE ER++ + + + Q NQ + + M +T+ +++ L +
Sbjct: 133 VQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKN 192
Query: 66 VELKSRML-----ESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEK-LKVE 119
+ L + L E E +++ +H ++S +T+ + L VE
Sbjct: 193 MALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE 252
Query: 120 LDEARLSEKQLKHQVDHQKE-LLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKT 178
L +A+ ++L+ +++ + E LL CK E + ++IEL ++
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQE----------------LEQMEIELKRLQQENM 296
Query: 179 TLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEA--VSYYNALEKARVANQDL 236
L + + +++L+ L +R VD+L+ E ++ + +Y A + +D
Sbjct: 297 NLLSDARSARMYRDELDALREKAVR-VDKLESEVSRYKERLHDIEFYKA--RVEELKEDN 353
Query: 237 QVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRM 296
QV L+ + L+ +G + D+ +E++ + +K K ++ + +R++++ +
Sbjct: 354 QVLLET--KTMLEDQLEGTRARS---DKLHELEKENLQLKAKLHDMEMERDMDRKKIEEL 408
Query: 297 KLQIATLLQMKGSQT---------EFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLY 347
+ TL +M Q+ E EQ R + E + H + E+ + K
Sbjct: 409 MEENMTL-EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
Query: 348 DSM-------ESKPSVDSGTLEDNTYYTDLLQMKLDN--LNKEIESTKGELSIQRM---- 394
++ E + +VDS +E N + +L+M+ +N L+K++E + E+ ++
Sbjct: 468 ENQSLTKTVEELRTTVDS--VEGNA--SKILKMEKENQRLSKKVEILENEIVQEKQSLQN 523
Query: 395 -----KALFESQRALD--IERKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVP 447
K L + + L+ IE +ER +++ E EN L + L+ + + V
Sbjct: 524 CQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVK 583
Query: 448 VLKKRREVLPVDI--TTAKDACV--NNSALGGEVYRLPPQKEETQSCPNS---LEDNNLQ 500
++K ++L I T++K + + + E+ + E + N LE N
Sbjct: 584 DIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENEL 643
Query: 501 LEKSVS---IYTPVVSLSPHKNLPVDMQLKKEKKCV--------KLIGVPADAEALSERS 549
L+K ++ I + +N ++ + +K KK + +L + + L E +
Sbjct: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEEN 703
Query: 550 ---GNTPNSPRLAAESKLQTEVKEGKETSSKLEKETCKKLHPILYVSSKSTPETQCPQQ 605
S + A+ Q ++ E KE S EKE KK +L S K T + Q
Sbjct: 704 LELRRNVESLKCASMKMAQLQL-ENKELES--EKEQLKKGLELLKASFKKTERLEVSYQ 759
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 79.3 bits (194), Expect = 9e-15
Identities = 154/667 (23%), Positives = 278/667 (41%), Gaps = 134/667 (20%)
Query: 19 ERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMT--ESYEQEKYTLQREVELKSRMLESL 76
ER + + L +E +NEL + K N +T E+ EQE L+RE + L+S
Sbjct: 625 ERAEELENELHHLEKENELLQK--KITNLKITCEKIEALEQENSELERENRKLKKTLDSF 682
Query: 77 SCECEAIKQQQKMHLEKLEEQLS-RSHGQEVNELKTKIEKLKVELDEARLSEKQLKHQVD 135
++ +K + + EE L R + + + K+ +L++E E ++QLK ++
Sbjct: 683 KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE 742
Query: 136 HQK------ELLSCKSEELRVMSERVQ---ESMSSEMLALQIELTEMESMKTTLKEEVNE 186
K E L + L + ++R+Q E+ + ++ L+ EL ++E TL++ + E
Sbjct: 743 LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE 802
Query: 187 LQY---RQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQA 243
L+ R EQLE +L ++ +L+++K++ EKE N+ L+ Q +
Sbjct: 803 LKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE--------------NKRLRQQA-EI 847
Query: 244 LQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATL 303
L+ N N +E + +++ K LK+ N+E ++R + I TL
Sbjct: 848 KDTTLEEN---NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
Query: 304 LQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNL---------------EKFKNLYD 348
+ ++ E E+L +Q N +++ L E+ + +++K L
Sbjct: 905 VTLR----EDLVSEKL--KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLES 958
Query: 349 SMES--KPSVD---------SGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRM--- 394
+ES K S++ LE++T Y L+ +L + K E+ K +RM
Sbjct: 959 KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS 1018
Query: 395 ---------KALFESQRA----LDIERKLFANERCLQLSESENMKLRAKLDELKLKYE-- 439
K ESQ L ++ +L ER ++E L+ +L +L+ +
Sbjct: 1019 SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL 1078
Query: 440 -------PEETVEV----PVLKKRREVLPVDITTAK-----------DACVNNSALGGEV 477
+TV + L+ + L V+ +T + S+L E
Sbjct: 1079 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN 1138
Query: 478 YRLPPQKEETQSCPNSL----EDNNLQLEKSVSIYTPVVS-----LSPHKNLPVD----- 523
+ ++E+ +S +SL E L E+ S Y ++S S HKNL V+
Sbjct: 1139 ESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLE 1198
Query: 524 ---MQLKKEK----KCVKLIGVPADAEALSERSGNTPNSPRLAAE-SKLQTEVKEGKETS 575
QL K+K K++ V + L ++ T +AAE KL E T
Sbjct: 1199 DRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHET-----VAAEYKKLCGENDRLNHTY 1253
Query: 576 SKLEKET 582
S+L KET
Sbjct: 1254 SQLLKET 1260
Score = 77.0 bits (188), Expect = 5e-14
Identities = 116/488 (23%), Positives = 205/488 (42%), Gaps = 63/488 (12%)
Query: 4 DIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQN-QLDKCRNEMMTMTESYEQEKYTL 62
DI T + R ++ E+LK Q L + +EL+ L+K E + E ++Y L
Sbjct: 900 DIKTLVTLR-EDLVSEKLKTQQMNNDLEKLTHELEKIGLNK---ERLLHDEQSTDDRYKL 955
Query: 63 QREVELKSRMLESLSCECEAIKQQQKMHLE-KLEEQLSRSHG--QEVNELKTKIEKLKVE 119
E +L+S + +SL IK+++ LE +LEE + + QE+ +K E LK
Sbjct: 956 L-ESKLESTLKKSLE-----IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1009
Query: 120 LDEARLSE----------KQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIE 169
DE R+ + K + + +ELL K + V ER ++ +E AL+ +
Sbjct: 1010 QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV--ERNNATLQAEKQALKTQ 1067
Query: 170 LTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKA 229
L ++E+ L+ ++ LQ + L+ T L Q +L+ E ++ S N +
Sbjct: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
Query: 230 RVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLI---SMKVKYQSLKKQN 286
+ L+ + + +++ D S +SL + E ERQ S+ K+ +LK +
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAH 1187
Query: 287 VFNREQMQRMKLQIATLLQMKGSQTEFE-----QQERLLAMLEQKN-----GEIKHLLGE 336
+ + ++ + LL+ KG + E +QE++L LE KN E K L GE
Sbjct: 1188 KNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML--LENKNHETVAAEYKKLCGE 1245
Query: 337 I---------------------RNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKL 375
+NL+ N +++ + L++ D+ KL
Sbjct: 1246 NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL 1305
Query: 376 DNLNKEIESTKGELSIQRMKALFESQRALDIERKLF-ANERCLQLSESENMKLRAKLDEL 434
+N + + KG L + L + Q + R L N L E + KL+EL
Sbjct: 1306 NNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1365
Query: 435 KLKYEPEE 442
+ + E E
Sbjct: 1366 RRQKEKLE 1373
Score = 69.3 bits (168), Expect = 1e-11
Identities = 111/535 (20%), Positives = 232/535 (43%), Gaps = 102/535 (19%)
Query: 19 ERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSC 78
E LK + L+ +E +N+ L++ +++ + E+E L+++ E+K LE +
Sbjct: 801 EELKISSKRLEQLEKENK---SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV 857
Query: 79 ECEAIKQQQK----------------MHLEKLEEQLSR-----------------SHGQE 105
+ ++++ K LEK ++L + S +
Sbjct: 858 KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917
Query: 106 VNELKTKIEKLKVELDEARLSEKQLKH---QVDHQKELLSCKSEELRVMSERVQESMSSE 162
++ +EKL EL++ L++++L H D + +LL K E S ++E +
Sbjct: 918 TQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAA 977
Query: 163 MLALQIELT----EMESMKTTLKEEVNELQYRQEQLELLITN--LMRQVDRLKEEKEERE 216
+ A E T ++ T+K+ L+ RQ++ ++ ++ + + ++ + E +E
Sbjct: 978 LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETT 1037
Query: 217 KEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMK 276
+E + + L + N LQ + Q ++ N+L A++ A++RQ +S++
Sbjct: 1038 RELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI----LALQRQTVSLQ 1093
Query: 277 VKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLL---AMLEQKNGEIKHL 333
+ +L+ QN KLQ+ S + Q +LL + LE +N +
Sbjct: 1094 EQNTTLQTQNA---------KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV--- 1141
Query: 334 LGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQR 393
I+ E K+LYDS+ ++D+ KL+ L+ E ++++ E I +
Sbjct: 1142 ---IKEREDLKSLYDSL----------IKDHE--------KLELLH-ERQASEYESLISK 1179
Query: 394 MKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELK--LKYEPEETVEVPVLKK 451
L + + L++E R L+ ++ +K + +L++L+ LK E E+ + + K
Sbjct: 1180 HGTLKSAHKNLEVE------HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML---LENK 1230
Query: 452 RREVLPVDITTAKDACVNNSALGGEVYRLPPQKEETQSCPNSLED--NNLQLEKS 504
E + + K C N L +L + E Q+ +L+ NN +LE++
Sbjct: 1231 NHETVAAEY---KKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1282
Score = 68.2 bits (165), Expect = 2e-11
Identities = 110/475 (23%), Positives = 196/475 (41%), Gaps = 69/475 (14%)
Query: 12 RLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSR 71
RLKE E+E + + +++ L+ L + + M E+ + L++ K R
Sbjct: 882 RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER 941
Query: 72 MLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLK 131
+L + ++ + K+ KLE L +S E+ E KI L+ L+E+ +QL+
Sbjct: 942 LLH----DEQSTDDRYKLLESKLESTLKKS--LEIKE--EKIAALEARLEESTNYNQQLR 993
Query: 132 HQVDHQK---ELLSCKSEELRVMS------------ERVQESMSSEMLALQIELTEMESM 176
++ K E L + +E R++ ER + + E+L ++ L E+E
Sbjct: 994 QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERN 1053
Query: 177 KTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDL 236
TL+ E L+ + +QLE NL Q+ L+ + +++ + K +V N L
Sbjct: 1054 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL 1113
Query: 237 QVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSL----KKQNVFNREQ 292
Q + Q + +SL E E+ ER+ +K Y SL +K + + Q
Sbjct: 1114 NSQSTSLMNQNAQLLIQQSSL--ENENESVIKERE--DLKSLYDSLIKDHEKLELLHERQ 1169
Query: 293 MQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYD---- 348
+ I+ +K + E + R LE + ++ G++ +LEK +
Sbjct: 1170 ASEYESLISKHGTLKSAHKNLEVEHR---DLEDRYNQLLKQKGQLEDLEKMLKVEQEKML 1226
Query: 349 ---------SMESKPSVDSGTLEDNTY-----YTDLLQMKLDNL-----NKEIESTKGEL 389
+ E K ++TY T++LQ NL N ++E T+ E
Sbjct: 1227 LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA 1286
Query: 390 SIQRMKALFESQRALDI-ERKLFANERCLQLS------ESENMKLRAKLDELKLK 437
++K E + LDI KL N +C LS E EN L ++ L L+
Sbjct: 1287 EFSKLK---EQYQQLDITSTKL--NNQCELLSQLKGNLEEENRHLLDQIQTLMLQ 1336
Score = 61.2 bits (147), Expect = 3e-09
Identities = 130/659 (19%), Positives = 274/659 (41%), Gaps = 94/659 (14%)
Query: 9 LRCRLKEAEEERLKAAQYGLQLVES---QNELQNQLDKCRNEMMTMTESYEQEKYTLQRE 65
++C+ KE ER++ + + + Q NQ + + M +T+ +++ L +
Sbjct: 133 VQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKN 192
Query: 66 VELKSRML-----ESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEK-LKVE 119
+ L + L E E +++ +H ++S +T+ + L VE
Sbjct: 193 MALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE 252
Query: 120 LDEARLSEKQLKHQVDHQKE-LLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKT 178
L +A+ ++L+ +++ + E LL CK E + ++IEL ++
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQE----------------LEQMEIELKRLQQENM 296
Query: 179 TLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEA--VSYYNALEKARVANQDL 236
L + + +++L+ L +R VD+L+ E ++ + +Y A + +D
Sbjct: 297 NLLSDARSARMYRDELDALREKAVR-VDKLESEVSRYKERLHDIEFYKA--RVEELKEDN 353
Query: 237 QVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRM 296
QV L+ + L+ +G + D+ +E++ + +K K ++ + +R++++ +
Sbjct: 354 QVLLET--KTMLEDQLEGTRARS---DKLHELEKENLQLKAKLHDMEMERDMDRKKIEEL 408
Query: 297 KLQIATLLQMKGSQT---------EFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLY 347
+ TL +M Q+ E EQ R + E + H + E+ + K
Sbjct: 409 MEENMTL-EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
Query: 348 DSM-------ESKPSVDSGTLEDNTYYTDLLQMKLDN--LNKEIESTKGELSIQRM---- 394
++ E + +VDS +E N + +L+M+ +N L+K++E + E+ ++
Sbjct: 468 ENQSLTKTVEELRTTVDS--VEGNA--SKILKMEKENQRLSKKVEILENEIVQEKQSLQN 523
Query: 395 -----KALFESQRALD--IERKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVP 447
K L + + L+ IE +ER +++ E EN L + L+ + + V
Sbjct: 524 CQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVK 583
Query: 448 VLKKRREVLPVDI--TTAKDACV--NNSALGGEVYRLPPQKEETQSCPNS---LEDNNLQ 500
++K ++L I T++K + + + E+ + E + N LE N
Sbjct: 584 DIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENEL 643
Query: 501 LEKSVS---IYTPVVSLSPHKNLPVDMQLKKEKKCV--------KLIGVPADAEALSERS 549
L+K ++ I + +N ++ + +K KK + +L + + L E +
Sbjct: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEEN 703
Query: 550 ---GNTPNSPRLAAESKLQTEVKEGKETSSKLEKETCKKLHPILYVSSKSTPETQCPQQ 605
S + A+ Q ++ E KE S EKE KK +L S K T + Q
Sbjct: 704 LELRRNVESLKCASMKMAQLQL-ENKELES--EKEQLKKGLELLKASFKKTERLEVSYQ 759
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 79.0 bits (193), Expect = 1e-14
Identities = 152/694 (21%), Positives = 293/694 (42%), Gaps = 128/694 (18%)
Query: 6 ITNLRCRLKEAE------EERLKAAQYGLQLVESQNE-LQNQLDKCRNEMMTMTESYEQE 58
+ L+ R+K E +E +++ + L+ S+ E LQ QLD+ E+ + + + E
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE 340
Query: 59 KYTLQREVELKSRMLESLSCECEAI----KQQQKMHLEKLEEQLSR---------SHGQE 105
K L ++ ++E L + + K+Q LE EE++++ + G+E
Sbjct: 341 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
Query: 106 VNELKTKIEKLKVELDEARLS--------EKQLKHQVDHQKELLSCKSEELRVMSER--- 154
+ E K K E+ E E LS ++LK ++D Q + + SEE R+ ++
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELS 460
Query: 155 --------VQESMSSEMLALQIELTEME----SMKTTLKEEVNELQYRQEQLELLITNLM 202
V + S E +A +L E E + T K + E ++ QEQ+++ +
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREF-QEQMKVALEKSQ 519
Query: 203 RQVDRLKEEKEEREKEAVSYYNALEKARVAN-----QDLQ----------VQLDQALQQA 247
+ ++ +EKE++E A+ +KA + +DLQ ++L+ +L+++
Sbjct: 520 SEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKS 579
Query: 248 LDPN-SKGNSLFAEVEDRRAAMERQLISM----KVKYQSLK-KQNVFNREQMQRMKLQIA 301
L N ++ L +E + +++ M K + +SLK +Q+ E++Q +K Q
Sbjct: 580 LQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ 639
Query: 302 TLLQMKGSQTEFEQQ------------------ERLLAMLEQKNGEIKHLLGEIRNLEKF 343
T ++ + E E++ E+ L L+ K E++ L E+ + K
Sbjct: 640 TEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKA 699
Query: 344 KNLYDSMESKPSVDSGTLEDNT-YYTDLLQMKLD----NLNKEIES--TKGELSIQRM-K 395
++ +E + SV L+D T L+ K+D + ++++S + E+SIQR K
Sbjct: 700 RH---KLEEELSV----LKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEK 752
Query: 396 ALFESQRALDI---ERKLFANER---------CLQLSESENMKLRAKLDELK----LKYE 439
AL + L++ ER E ++ SE E + AKLD + +E
Sbjct: 753 ALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHE 812
Query: 440 PEETVEVPVLKKRREVLPVD---ITTAKDACVNNSALGGEVYRLPPQKEETQSCPNSLED 496
+ E + + ++++L ++ I K + L K + Q LE
Sbjct: 813 QTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEK 872
Query: 497 NNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEALSERSGNTPN-- 554
N ++E+ V T V KE++ K I V + L R G
Sbjct: 873 QNSEMEQKVKSLTQVYESKLEDG-------NKEQEQTKQILVEKENMILQMREGQKKEIE 925
Query: 555 --SPRLAAESKLQTEVKEGKETSSKLEKETCKKL 586
+ +L+A+ + E ET K +++ +K+
Sbjct: 926 ILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKV 959
Score = 63.9 bits (154), Expect = 4e-10
Identities = 110/611 (18%), Positives = 265/611 (43%), Gaps = 73/611 (11%)
Query: 6 ITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQRE 65
+ L+ +L + E ER+ + ++ + ++ +LD + ++ + + E++ ++++
Sbjct: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQK 880
Query: 66 VELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARL 125
V+ +++ ES + ++Q K L + E + + + E++ +KL + D +
Sbjct: 881 VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI 940
Query: 126 SEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVN 185
++ + + +Q++ K E+++ ++ +QE++ ++L + +L + E T L+
Sbjct: 941 LNEEYETKFKNQEK----KMEKVKQKAKEMQETLKKKLLDQEAKL-KKELENTALELSQK 995
Query: 186 ELQYRQEQLELLITN---LMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQ 242
E Q+ + LE+ N + V RL+ ++E+ + + R N + + +
Sbjct: 996 EKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR-----RELNDVISIWEKK 1050
Query: 243 ALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIAT 302
QQA + E E A ++++++ + + + K+ + +E+
Sbjct: 1051 LNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEE---------- 1100
Query: 303 LLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVD-SGTL 361
+K T E QE+ L+QK+ + L ++ K K + +E VD + +L
Sbjct: 1101 --GVKQDTTLNELQEQ----LKQKSAHVNSL---AQDETKLKAHLEKLE----VDLNKSL 1147
Query: 362 EDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSE 421
++NT+ LQ +L L E K ++S ++ KL + Q +
Sbjct: 1148 KENTF----LQEQLVELKMLAEEDKRKVS--------------ELTSKLKTTDEEFQSLK 1189
Query: 422 SENMKLRAKLDELKLKYE---PEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVY 478
S + K L++ L+++ E +++ + K+ E L ++ T + +++S +
Sbjct: 1190 SSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEAL-LEAKTNELINISSSKTNAILS 1248
Query: 479 RLPPQKEET---------QSCP-NSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKK 528
R+ + T ++C + LE QL + + + H+ + Q+K
Sbjct: 1249 RISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKS 1308
Query: 529 EKKCVKLIGVPADAEALSERSGNTPN--SPRLAAESKLQTEVKEGKETSSKLEKETCKKL 586
K ++ + + EAL + GN S + + ++L+ E+ E + +++E +K
Sbjct: 1309 MKADIE--SLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKK 1366
Query: 587 HPILYVSSKST 597
I +S + T
Sbjct: 1367 VEISSLSKQLT 1377
Score = 63.5 bits (153), Expect = 5e-10
Identities = 98/446 (21%), Positives = 185/446 (41%), Gaps = 57/446 (12%)
Query: 14 KEAEEERLKAAQYGLQLVESQNELQNQLDKCRNE--MMTMTESYEQEKYTLQREVELKSR 71
+E +E++++ + QL + +LQN + E + ++ + Y++EK L +V+ S
Sbjct: 1360 EELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSF 1419
Query: 72 MLESLSCECEAIKQQQKMHLEKLEEQLSRS------HGQEVNELKTKIEKLKVELDEARL 125
+++LS E + +Q K E ++ H V EL+ ++E E E
Sbjct: 1420 KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDE 1479
Query: 126 SEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVN 185
LK ++D Q + C E+ ++++ S+ L+ EL + L++ +
Sbjct: 1480 QINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESN----LETELKSQTARIMELEDHIT 1535
Query: 186 ELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQ 245
+ E L ++ N +Q D E KE L Q LQ
Sbjct: 1536 QKTIEIESLNEVLKNYNQQKDI--EHKE--------------------------LVQKLQ 1567
Query: 246 QALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQ 305
+ + ++ E E++ +E Q+ SMK + ++ KK+ ++ + ++ L
Sbjct: 1568 HFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALED 1627
Query: 306 MKGSQTEFEQQERLLAMLEQKNGEI-KHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDN 364
S++ + E L EQK I K LL ++ EK + ES S + L++
Sbjct: 1628 RLESESAAKLAE-LKRKAEQKIAAIKKQLLSQME--EKEEQYKKGTESHLSELNTKLQER 1684
Query: 365 TYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESEN 424
+L+ KL K +ES++ E I A A E++ ++ C+Q + E
Sbjct: 1685 EREVHILEEKL----KSVESSQSETLIVPRSA---KNVAAYTEQEEADSQGCVQKTYEEK 1737
Query: 425 MK-LRAKLDE-----LKLKYEPEETV 444
+ L+ L E ++ E EETV
Sbjct: 1738 ISVLQRNLTEKEKLLQRVGQEKEETV 1763
Score = 63.5 bits (153), Expect = 5e-10
Identities = 79/362 (21%), Positives = 164/362 (45%), Gaps = 40/362 (11%)
Query: 14 KEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRML 73
K +E+ L ++ E + L Q + R EM +T YE K ++++ +++
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYE--KLQALQQMDGRNKPT 1897
Query: 74 ESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKI-----EKLKVELDEARLSEK 128
E L E +++ K HL ++ +L + + N+L+ K+ EK K+ + RL +
Sbjct: 1898 ELLE---ENTEEKSKSHL--VQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD 1952
Query: 129 QLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQ 188
+ +HQ+EL K E + E++++ +EL ++K ++E +L
Sbjct: 1953 LRMLRKEHQQELEILKKEYDQEREEKIKQEQED------LELKHNSTLKQLMREFNTQLA 2006
Query: 189 YRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQAL 248
++++LE+ I + + ++ E E +E + L+K + DL+ + + ++ L
Sbjct: 2007 QKEQELEMTIKETINKAQEVEAELLESHQEETN--QLLKKIAEKDDDLK-RTAKRYEEIL 2063
Query: 249 DPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKG 308
D ++ + A+V D ++ QL ++ KYQ EQ + T++++
Sbjct: 2064 D--AREEEMTAKVRD----LQTQLEELQKKYQQ-------KLEQEENPGNDNVTIMEL-- 2108
Query: 309 SQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYT 368
QT+ Q+ L++ + K E + +I NLE Y+ +V + N Y+T
Sbjct: 2109 -QTQLAQKTTLISDSKLKEQEFRE---QIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHT 2164
Query: 369 DL 370
D+
Sbjct: 2165 DV 2166
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 79.0 bits (193), Expect = 1e-14
Identities = 131/620 (21%), Positives = 261/620 (42%), Gaps = 102/620 (16%)
Query: 6 ITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQRE 65
I +L+ L +AE+E+ L E L + + E + E+++Q LQ E
Sbjct: 1003 IDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAE 1062
Query: 66 VELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELD-EAR 124
+ S + ++ K+ LE+ E L S QE +L+ E+ K +L+ + +
Sbjct: 1063 EDRVSALTKA------------KLRLEQQVEDLECSLEQE-KKLRMDTERAKRKLEGDLK 1109
Query: 125 LSEKQLKHQVDHQKEL---LSCKSEELRVMSERVQESMSSEMLALQIE--LTEMESMKTT 179
L+++ + +++L L K EL +S RV++ ++L Q++ + E+++
Sbjct: 1110 LTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDE---QLLGAQMQKKIKELQARAEE 1166
Query: 180 LKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQ 239
L+EE+ + + ++E R+++ L E EE + K L+ +
Sbjct: 1167 LEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRE 1226
Query: 240 LDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQ 299
L++A AL + +L + + A + Q+ S++ Q L+K+ R ++ +
Sbjct: 1227 LEEA---ALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAAN 1283
Query: 300 IATLLQMKGS---------------QTEFEQQERLLA-------MLEQKNGEIKHLLGE- 336
+ TL + K S + + E+ +R LA L+ ++GE+ LL E
Sbjct: 1284 VETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEK 1343
Query: 337 --------------IRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLL----------- 371
++LE+ + + S + ++ + DLL
Sbjct: 1344 ECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQ 1403
Query: 372 ---QMKLDNLNKEIESTKGEL---SIQRMKALFESQRALDI------ERKLFANERCLQL 419
Q L N E+ + + +IQR + L E+++ L + E AN +C L
Sbjct: 1404 AELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSL 1463
Query: 420 SESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPV---------DITTAKDACVNN 470
E ++L+ + +++ L+ E + + KK+R + ++ +A
Sbjct: 1464 -EKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRE 1522
Query: 471 S-ALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKE 529
S LG E++RL EE +L+ N L++ +S T VSLS K++ +L+K
Sbjct: 1523 SRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLS-GKSI---QELEKT 1578
Query: 530 KKCVKLIGVPADAEALSERS 549
KK ++ G ++ +A E +
Sbjct: 1579 KKALE--GEKSEIQAALEEA 1596
Score = 67.0 bits (162), Expect = 5e-11
Identities = 139/648 (21%), Positives = 260/648 (40%), Gaps = 108/648 (16%)
Query: 11 CRLKEAEEERLK-------------AAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQ 57
CR +EAE RL+ A + E EL Q+D + + + E+
Sbjct: 1213 CRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDS----LQRVRQKLEK 1268
Query: 58 EKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLK 117
EK L+ EV+ + +E+L+ + E+L R++ +++E K K+E+L+
Sbjct: 1269 EKSELRMEVDDLAANVETLT------------RAKASAEKLCRTYEDQLSEAKIKVEELQ 1316
Query: 118 VELDEAR----------------LSEKQ-LKHQVDHQKELLSCKSEELRVMSERVQESMS 160
+L +A L EK+ L Q+ K L + EELR E +ES +
Sbjct: 1317 RQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLE--EESKA 1374
Query: 161 SEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAV 220
LA ++ + L+E+ E Q +L+ L++ +V + + + E +A+
Sbjct: 1375 KSALAHAVQALRHDC--DLLREQHEEEAEAQAELQRLLSKANAEV---AQWRSKYEADAI 1429
Query: 221 SYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLF-------AEVEDRRAAMERQL- 272
LE+A+ + L ++L +A + N+K +SL E ED +ER
Sbjct: 1430 QRTEELEEAK---KKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATS 1486
Query: 273 --ISMKVKYQSLKKQNVFNREQMQRMKLQI-ATLLQMKGSQTEFEQ----QERLLAMLEQ 325
++ K + L++ R Q + M+ ++ A + +G TE + E L LE
Sbjct: 1487 AAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALET 1546
Query: 326 KNGEIKHLLGEI--------------RNLEKFKNLYDSMESKPSVD----SGTLEDNTYY 367
E K+L EI + LEK K + +S+ G LE
Sbjct: 1547 LKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETK 1606
Query: 368 TDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALD-IERKLFANERCLQLSESENMK 426
T +Q++L + E++ E + QRA++ ++ L A R + +E ++
Sbjct: 1607 TLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETR----ARNEALR 1662
Query: 427 LRAKLD------ELKLKYEPEETVEVPV--------LKKRREVLPVDITTAKDACVNNSA 472
L+ K++ EL+L + + E LK+ + + A + A
Sbjct: 1663 LKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQA 1722
Query: 473 LGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKC 532
L L + EE ++ E + E+ + T ++L +N + Q KK +
Sbjct: 1723 LERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEAD 1782
Query: 533 VKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEK 580
+ + + A R + + + E+K+ ++TS+ LE+
Sbjct: 1783 LAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1830
Score = 66.2 bits (160), Expect = 8e-11
Identities = 108/481 (22%), Positives = 204/481 (42%), Gaps = 80/481 (16%)
Query: 8 NLRCRLKEAEEERLKAAQYGLQL-VESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREV 66
N +C E + RL+ + L +E LDK + + E +++ +QRE+
Sbjct: 1457 NAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQREL 1516
Query: 67 ELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLS 126
E R L E ++ + LE LE L R E K E++ D+ LS
Sbjct: 1517 EAAQRESRGLGTELFRLRHGHEEALEALET-LKR-------ENKNLQEEISDLTDQVSLS 1568
Query: 127 EKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSE---MLALQIELTEMES-MKTTLKE 182
K ++ +++ K+ L + E++ E + ++ E L +Q+EL+++++ + L E
Sbjct: 1569 GKSIQ-ELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAE 1627
Query: 183 EVNELQYRQEQLELLITNLMRQVD---RLKEEKEEREKEAVSYYNALE-----------K 228
+ E + + + +L +D R + E +K+ N LE +
Sbjct: 1628 KDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATE 1687
Query: 229 ARVANQDLQVQL---------DQAL-----QQALDPNSKGNSLFAEVEDRRAAMERQLIS 274
A+ A + +Q QL +Q L +QA + + L AE+E+ RAA+E+ S
Sbjct: 1688 AQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERS 1747
Query: 275 MKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLL 334
++ Q L + E++ + Q LL Q+++L A L Q +GE++
Sbjct: 1748 RRLAEQELLEAT----ERLNLLHSQNTGLL---------NQKKKLEADLAQLSGEVEEAA 1794
Query: 335 GEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRM 394
E R E+ ++K ++ M + L KE +++ ++RM
Sbjct: 1795 QERREAEE--------KAKKAITDAA------------MMAEELKKEQDTS---AHLERM 1831
Query: 395 KALFESQRALDIERKL-FANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRR 453
K E Q +++ +L A + L+ + + KL AK+ EL+ + + E+ LK R
Sbjct: 1832 KKTLE-QTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVR 1890
Query: 454 E 454
+
Sbjct: 1891 K 1891
Score = 50.4 bits (119), Expect = 5e-06
Identities = 58/287 (20%), Positives = 122/287 (42%), Gaps = 11/287 (3%)
Query: 2 EADIITNL-RCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQ--- 57
EA T L + +LKE + R + + +L E L+ + E+ + + EQ
Sbjct: 1687 EAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGER 1746
Query: 58 EKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLK 117
+ ++E+ + L L + + Q+K LE QLS + E + EK K
Sbjct: 1747 SRRLAEQELLEATERLNLLHSQNTGLLNQKKK-LEADLAQLSGEVEEAAQERREAEEKAK 1805
Query: 118 VELDEARLSEKQLKHQVD---HQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEME 174
+ +A + ++LK + D H + + + +R + R++E+ + + + ++ ++E
Sbjct: 1806 KAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLE 1865
Query: 175 SMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQ 234
+ L+ E++ Q + + + R+V L + EE K + ++K + +
Sbjct: 1866 AKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVK 1925
Query: 235 DLQVQLDQALQQA---LDPNSKGNSLFAEVEDRRAAMERQLISMKVK 278
+ Q ++A QQA L K + E+R E Q ++ +
Sbjct: 1926 SYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRAR 1972
Score = 34.3 bits (77), Expect = 0.34
Identities = 65/330 (19%), Positives = 130/330 (39%), Gaps = 46/330 (13%)
Query: 140 LLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLIT 199
L S ++EE + + A + + E+E ++ +E N+L + + + +
Sbjct: 889 LRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA 948
Query: 200 NLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFA 259
+ + L + K + E + LE N DL + + + + + L
Sbjct: 949 DAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDL-- 1006
Query: 260 EVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERL 319
++ +A E+Q KVK + E+M + +A L + K + E QQ
Sbjct: 1007 KLTLAKAEKEKQATENKVKNLT---------EEMAALDESVARLTKEKKALQEAHQQ--A 1055
Query: 320 LAMLEQKNGEIKHLL-GEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNL 378
L L+ + + L ++R ++ ++L S+E + L+M +
Sbjct: 1056 LGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKK---------------LRMDTERA 1100
Query: 379 NKEIESTKGELSIQRMKALFESQRALDIERKLFANERCL-QLS---ESENM--------- 425
+++E G+L + + +Q +E KL + L QLS E E +
Sbjct: 1101 KRKLE---GDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKI 1157
Query: 426 -KLRAKLDELKLKYEPEETVEVPVLKKRRE 454
+L+A+ +EL+ + E E V K+R E
Sbjct: 1158 KELQARAEELEEELEAERAARARVEKQRAE 1187
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 77.8 bits (190), Expect = 3e-14
Identities = 117/490 (23%), Positives = 213/490 (43%), Gaps = 86/490 (17%)
Query: 2 EADIITNLRCRLKEAEEERLKAAQYGLQL-VESQNELQNQLDKCRNEMMTMTESYEQEKY 60
EA N +C E + RL+ L + VE N LDK + + ++Q+
Sbjct: 1402 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1461
Query: 61 TLQREVELKSRMLESLSCECEAIKQQQKMHLEKLE-----------------EQLSRSHG 103
Q E+E + SLS E +K + LE LE EQL S G
Sbjct: 1462 ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG-SSG 1520
Query: 104 QEVNEL---KTKIEKLKVELDEA-RLSEKQLKHQ----VDHQKELLSCKSEELRVMSERV 155
+ ++EL + ++E K+EL A +E L+H+ + Q E K+E R ++E+
Sbjct: 1521 KTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD 1580
Query: 156 QESMSSEMLALQIELTEMESMKTTLKEEV---NELQYRQEQLELLITNLMRQVDRLKEEK 212
+E ++ L++ ++S++T+L E NE ++++E + + Q+
Sbjct: 1581 EEMEQAKRNHLRV----VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMA 1636
Query: 213 EEREKEAVSYYNALEKARVANQDLQVQLDQALQQALD-------PNSKGNSLFAEVEDRR 265
E +K+ S + L +D Q+QLD A++ D + N L AE+E+ R
Sbjct: 1637 AEAQKQVKSLQSLL-------KDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 1689
Query: 266 AAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQ 325
A +E+ S K+ Q L + E++Q + Q +L+ Q++++ A L Q
Sbjct: 1690 AVVEQTERSRKLAEQEL----IETSERVQLLHSQNTSLI---------NQKKKMDADLSQ 1736
Query: 326 KNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIEST 385
E++ + E RN E+ ++K ++ M + L KE +++
Sbjct: 1737 LQTEVEEAVQECRNAEE--------KAKKAITDAA------------MMAEELKKEQDTS 1776
Query: 386 KGELSIQRMKALFESQRALDIERKL-FANERCLQLSESENMKLRAKLDELKLKYEPEETV 444
++RMK E Q D++ +L A + L+ + + KL A++ EL+ + E E+
Sbjct: 1777 ---AHLERMKKNME-QTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKR 1832
Query: 445 EVPVLKKRRE 454
+K R+
Sbjct: 1833 NAESVKGMRK 1842
Score = 74.7 bits (182), Expect = 2e-13
Identities = 109/523 (20%), Positives = 229/523 (43%), Gaps = 47/523 (8%)
Query: 9 LRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEM----MTMTESYEQEKYTLQR 64
L ++KE E + +L + +L+++ + + ++ +T+ + E+EK+ +
Sbjct: 915 LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAK-VEKEKHATEN 973
Query: 65 EVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEAR 124
+V+ + E ++ E I + L K ++ L +H Q +++L+ + +K+ L +A+
Sbjct: 974 KVK---NLTEEMAGLDEIIAK-----LTKEKKALQEAHQQALDDLQAEEDKVNT-LTKAK 1024
Query: 125 LSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKE-- 182
+ +L+ QVD + L + +++R+ ER + + ++ Q + ++E+ K L E
Sbjct: 1025 V---KLEQQVDDLEGSLE-QEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERL 1080
Query: 183 -----EVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQ 237
E+N L R E + L + L +++ L+ EE E+E + A K DL
Sbjct: 1081 KKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLS 1140
Query: 238 VQLDQALQQALDPNSKGNSLFAEVEDRRAA----MERQLISMKVKYQ----SLKKQNVFN 289
+L++ + + L+ S+ E+ +R A M R L ++++ +L+K++
Sbjct: 1141 RELEE-ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHA-- 1197
Query: 290 REQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKF-KNLYD 348
+ + + QI L ++K + E E+ E L L+ ++ ++ NLEK + L D
Sbjct: 1198 -DSVAELGEQIDNLQRVK-QKLEKEKSEFKLE-LDDVTSNMEQIIKAKANLEKMCRTLED 1254
Query: 349 SM---ESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALD 405
M SK ++ D T LQ + L+++++ + +S L +Q+ D
Sbjct: 1255 QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 1314
Query: 406 IERKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVP----VLKKRREVLPVDIT 461
++R+L + R D L+ +YE E + + K EV
Sbjct: 1315 LKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1374
Query: 462 TAKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKS 504
DA L +L + +E + ++ LEK+
Sbjct: 1375 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417
Score = 73.2 bits (178), Expect = 7e-13
Identities = 99/473 (20%), Positives = 207/473 (43%), Gaps = 62/473 (13%)
Query: 29 QLVESQNE---LQNQLDKCRN---EMMTMTESYEQEKYTLQREV-ELKSRM--------- 72
+L SQ E L +L K +N E + E++++E LQ E+ +L ++
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE 1525
Query: 73 LESLSCECEAIKQQQKMHLEKLEEQLSRSHGQ------EVNELKTKIEKLKVELDEARLS 126
LE + + EA K + + LE+ E L G+ E N++K +IE+ E DE
Sbjct: 1526 LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEM-- 1583
Query: 127 EKQLKHQVDHQKELLSCKSEELRVMSE--RVQESMSSEMLALQIELTEMESMKTTLKEEV 184
E+ ++ + L + E R +E RV++ M ++ ++I+L+ M +++V
Sbjct: 1584 EQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV 1643
Query: 185 NELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQAL 244
LQ + ++ + + +R D LKE E+ LE+ R + + A
Sbjct: 1644 KSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAE 1703
Query: 245 QQALDPNSKGNSLFAE---VEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIA 301
Q+ ++ + + L ++ + +++ M+ L ++ + + Q N E+ + + A
Sbjct: 1704 QELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAV-QECRNAEEKAKKAITDA 1762
Query: 302 TLL--QMKGSQTEFEQQERLLAMLEQKNGEIKHLLGE------------IRNLE-KFKNL 346
++ ++K Q ER+ +EQ +++H L E ++ LE + + L
Sbjct: 1763 AMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL 1822
Query: 347 YDSMESKPSVDSGT----------LEDNTYYTD-------LLQMKLDNLNKEIESTKGEL 389
+ +E++ ++ + +++ TY T+ LQ +D L ++++ K +
Sbjct: 1823 ENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQA 1882
Query: 390 SIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPEE 442
+A + ++ +L E ++ES+ KLRAK ++ K EE
Sbjct: 1883 EEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLNEE 1935
Score = 66.6 bits (161), Expect = 6e-11
Identities = 110/477 (23%), Positives = 209/477 (43%), Gaps = 79/477 (16%)
Query: 13 LKEAEEERLKAAQYGLQLVESQNELQNQLDKC---RNEMMTMTESYEQEKYTLQREVELK 69
LK AE E+ A+ + E L+ L+K R E+ S QEK LQ +V+ +
Sbjct: 840 LKSAEREKEMAS-----MKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 70 SRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQ 129
L C+ + + + K++E R +E + +K K+E DE +
Sbjct: 895 QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-DEC----SE 949
Query: 130 LKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKE----EVN 185
LK +D EL K E+ + +E ++++ EM L + ++ K L+E ++
Sbjct: 950 LKRDID-DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1008
Query: 186 ELQYRQEQLELLI---TNLMRQVDRLKEEKEEREKEAVSYYNA-------LEKARVANQD 235
+LQ ++++ L L +QVD L+ E+ +K + A L+ + + D
Sbjct: 1009 DLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD 1068
Query: 236 LQVQLDQALQQALDPNSKGNSLFAEVEDRRA---AMERQLISMKVKYQSLKKQNVFNREQ 292
L+ Q ++ + + N+L A +ED +A ++++L ++ + + L+++ E+
Sbjct: 1069 LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEE--LEAER 1126
Query: 293 MQRMKLQI---------------------ATLLQM---KGSQTEFE-----------QQE 317
R K++ AT +Q+ K + EF+ Q E
Sbjct: 1127 TARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE 1186
Query: 318 RLLAMLEQKNGEIKHLLGE-IRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLD 376
A L +K+ + LGE I NL++ K + +S+ ++ L+D T + +
Sbjct: 1187 ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE---LDDVTSNMEQIIKAKA 1243
Query: 377 NLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDE 433
NL K + + +++ R KA E+QR+++ L + LQ +EN +L +LDE
Sbjct: 1244 NLEKMCRTLEDQMNEHRSKA-EETQRSVN---DLTSQRAKLQ---TENGELSRQLDE 1293
Score = 57.8 bits (138), Expect = 3e-08
Identities = 57/263 (21%), Positives = 120/263 (45%), Gaps = 14/263 (5%)
Query: 28 LQLVESQNEL-QNQLDKCRNEMMTMTESYEQEKYTLQRE-VELKSRMLESLSCECEAIKQ 85
+ +VE +N L Q +L+ E+ + E E+ + ++E +E R+ S I Q
Sbjct: 1671 IAIVERRNNLLQAELE----ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ 1726
Query: 86 QQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKS 145
++KM + QL + V E + EK K + +A + ++LK + D L K
Sbjct: 1727 KKKMDADL--SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1784
Query: 146 EELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQV 205
+ + + +E +AL+ +++ ++ ++E NEL+ Q++ + + +
Sbjct: 1785 NMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSE 1844
Query: 206 DRLKE---EKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSL---FA 259
R+KE + EE K + + ++K ++ + + Q ++A +QA SK +
Sbjct: 1845 RRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1904
Query: 260 EVEDRRAAMERQLISMKVKYQSL 282
E E+R E Q+ ++ K + +
Sbjct: 1905 EAEERADIAESQVNKLRAKSRDI 1927
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 76.6 bits (187), Expect = 6e-14
Identities = 147/637 (23%), Positives = 275/637 (43%), Gaps = 111/637 (17%)
Query: 12 RLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTE----SYEQEKYTLQREVE 67
+L + ++ +A Q L ++ + + N L K ++ T+ S EQEK L+ ++E
Sbjct: 995 KLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEK-KLRADLE 1053
Query: 68 LKSRMLES-LSCECEAI------KQQQKMHLEKLEEQLSRSHGQ-------------EVN 107
R LE L E+I KQQ + L+K E +LS+ + ++
Sbjct: 1054 RAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIK 1113
Query: 108 ELKTKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQ 167
EL+ +IE+L+ E++ +E L+ +++ Q+ L+ + EE+ SER++E+ S + Q
Sbjct: 1114 ELQARIEELEEEIE----AEHTLRAKIEKQRSDLARELEEI---SERLEEA--SGATSAQ 1164
Query: 168 IELT-----EMESMK-----TTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREK 217
IE+ E + M+ TL+ E R++Q + + L Q+D L+ K++ EK
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQAD-SVAELGEQIDNLQRVKQKLEK 1223
Query: 218 EAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKV 277
E +L++++D + ++ SK S +ER +++
Sbjct: 1224 E--------------KSELKMEIDD-MASNIEALSKSKS----------NIERTCRTVED 1258
Query: 278 KYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQT-EFEQQERLLAMLEQKNGEIKHLLGE 336
++ +K ++ + + + +Q A L G + E++E L++ L + + L E
Sbjct: 1259 QFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEE 1318
Query: 337 I-RNLE---KFKNLYDSMESKPSVDSGTL----EDNTYYTDLLQMKLDNLNKEIES--TK 386
+ R +E K KN D L E+ LQ L N E+ TK
Sbjct: 1319 LKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTK 1378
Query: 387 GEL-SIQRMKALFESQRAL------DIERKLFANERCLQLSESENMKLRAKLDELKLKYE 439
E +IQR + L E+++ L E AN +C L E +L+ ++++L E
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASL-EKTKQRLQGEVEDLMRDLE 1437
Query: 440 PEETVEVPVLKKRR----------EVLPVDITTAKDACVNNSALGGEVYRLPPQKEETQS 489
T + KK+R + L + A + +L E++++ EE
Sbjct: 1438 RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497
Query: 490 CPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAE-ALSER 548
+L N L++ +S T ++ KNL + +K KK V+ +D + AL E
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIA-ETGKNL---QEAEKTKKLVE--QEKSDLQVALEEV 1551
Query: 549 SGNTPNSPRLAAESKLQTEVKEGKETSSKLEKETCKK 585
G+ + ESK+ E + S+L+++ +K
Sbjct: 1552 EGSLEHE-----ESKILRVQLELSQVKSELDRKVIEK 1583
Score = 70.9 bits (172), Expect = 3e-12
Identities = 118/602 (19%), Positives = 251/602 (41%), Gaps = 83/602 (13%)
Query: 32 ESQNELQNQLDKCRNEM-----------MTMTESYEQEKYTLQREVELKSRMLESLSCEC 80
E++ ELQ L K +E+ + TE E+ K L + ++ E+ + +C
Sbjct: 1356 EAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKC 1415
Query: 81 ---EAIKQQQKMHLEKLEEQLSRSH-------------GQEVNELKTKIEKLKVELDEAR 124
E KQ+ + +E L L RSH + + E K K+++ + EL+ A+
Sbjct: 1416 ASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQ 1475
Query: 125 LSEKQLKHQVDHQK---ELLSCKSEELRVMSERVQESMS---SEMLALQIELTEMESMKT 178
+ L ++ + E + + E LR ++ +QE +S ++ L E E K
Sbjct: 1476 KESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKK 1535
Query: 179 TLKEEVNELQYRQEQLELLI----TNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQ 234
+++E ++LQ E++E + + ++R L + K E +++ + +E+ + +Q
Sbjct: 1536 LVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ 1595
Query: 235 DLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQ 294
+ +ALQ LD + + ++ + ME L M+++ +Q ++ ++
Sbjct: 1596 ----RAAEALQSVLDAEIRSRNDALRLKKK---MEGDLNEMEIQLGHSNRQMAETQKHLR 1648
Query: 295 RMKLQIA-TLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESK 353
++ Q+ + L + + E + LA++E++NG + + LE+ K + E
Sbjct: 1649 TVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLL------LEELEEMKVALEQTERT 1702
Query: 354 PSVDSGTLEDNTYYTDLLQMK---LDNLNKEIESTKGELSIQRMKALFESQRALDIERKL 410
+ L D + LL + L N K++E+ + + ++ ES+ A + +K
Sbjct: 1703 RRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKA 1762
Query: 411 FANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNN 470
+ A + +LK E + + + +KK E D+ D
Sbjct: 1763 ITD---------------AAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807
Query: 471 SALGG--EVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVV------SLSPHKNLPV 522
+ GG ++ +L + E ++ + + + K Y V + HKN+ +
Sbjct: 1808 ALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNI-L 1866
Query: 523 DMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKET 582
+Q +K K+ AE E++ + +L+ ++Q E++E E + E +
Sbjct: 1867 RLQDLVDKLQAKVKSYKRQAEEAEEQA-----NTQLSRCRRVQHELEEAAERADIAESQV 1921
Query: 583 CK 584
K
Sbjct: 1922 NK 1923
Score = 65.5 bits (158), Expect = 1e-10
Identities = 112/529 (21%), Positives = 228/529 (43%), Gaps = 73/529 (13%)
Query: 9 LRCRLKEAE-EERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVE 67
+R L+EA + AA + +S EL Q+D + + + E+EK L+ E++
Sbjct: 1178 MRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN----LQRVKQKLEKEKSELKMEID 1233
Query: 68 LKSRMLESLSCE-------CEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVEL 120
+ +E+LS C ++ Q K E+Q H ++N K +++ EL
Sbjct: 1234 DMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH--DLNMQKARLQTQNGEL 1291
Query: 121 DEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTL 180
++ L Q+ K+ L+ + EEL+ E ++ ++ ALQ + + L
Sbjct: 1292 SHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCD----LL 1347
Query: 181 KEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQL 240
+E+ E Q + +L+ ++ +V + + + E +A+ LE+A+ +L
Sbjct: 1348 REQYEEEQEAKAELQRALSKANSEV---AQWRTKYETDAIQRTEELEEAK-------KKL 1397
Query: 241 DQALQQALDPNSKGNSLFAEVEDRRAAMERQLIS-MKVKYQSLKKQNVFNREQMQRMKLQ 299
Q LQ+A + NS A +E + ++ ++ M+ +S +++Q K+
Sbjct: 1398 AQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVL 1457
Query: 300 IATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSG 359
++ SQ E E ++ E + L E L K +N Y+ + +
Sbjct: 1458 AEWKQKLDESQAELEAAQK----------ESRSLSTE---LFKMRNAYEEVVDQ------ 1498
Query: 360 TLEDNTYYTDLLQMKLDNLNKEI-ESTKGELSIQRMKALFESQRALDIERKLFANERCLQ 418
LE LQ ++ +L ++I E+ K ++ K L E +++ D++ L E L+
Sbjct: 1499 -LETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKS-DLQVALEEVEGSLE 1556
Query: 419 LSESENMKLRAKLDELKLKYEP---EETVEVPVLKKR--------REVLPVDITTAKDAC 467
ES+ ++++ +L ++K + + E+ E+ LK+ + VL +I + DA
Sbjct: 1557 HEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDAL 1616
Query: 468 VNNSALGGEVYRLP-------PQKEETQ----SCPNSLEDNNLQLEKSV 505
+ G++ + Q ETQ + L+D+ L L+ ++
Sbjct: 1617 RLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDAL 1665
Score = 62.8 bits (151), Expect = 9e-10
Identities = 91/435 (20%), Positives = 190/435 (43%), Gaps = 46/435 (10%)
Query: 13 LKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRM 72
LK AE E+ A + E E + + R E+ S QEK LQ +V+ ++
Sbjct: 844 LKSAEAEKEMATMK--EDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETEN 901
Query: 73 LESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLKH 132
L CE + + + + K++E R +E E+ +++ K L++ S LK
Sbjct: 902 LMDAEERCEGLIKSKILLEAKVKELTERL--EEEEEMNSELVAKKRNLEDKCSS---LKR 956
Query: 133 QVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKE----EVNELQ 188
+D EL K E+ + +E +++S EM AL+ ++++ K +L+E +++LQ
Sbjct: 957 DID-DLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQ 1015
Query: 189 YRQEQLELLI---TNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQ 245
++++ LI L +Q D L+ E+ +K LE+A+ + L+ L + +
Sbjct: 1016 VEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRAD----LERAK---RKLEGDLKMSQE 1068
Query: 246 QALD-PNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLL 304
+D N K ++E++ E +L ++ K + ++ +++++ ++ +I L
Sbjct: 1069 SIMDLENDK-----QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEEL- 1122
Query: 305 QMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDN 364
+ E E + L A +E++ ++ L EI + +E S +E N
Sbjct: 1123 -----EEEIEAEHTLRAKIEKQRSDLARELEEIS---------ERLEEASGATSAQIEMN 1168
Query: 365 TYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESEN 424
Q +L + + + R K ++ ++ ++ +R Q E E
Sbjct: 1169 KKREAEFQKMRRDLEEATLQHEATAATLRKK---QADSVAELGEQIDNLQRVKQKLEKEK 1225
Query: 425 MKLRAKLDELKLKYE 439
+L+ ++D++ E
Sbjct: 1226 SELKMEIDDMASNIE 1240
Score = 60.5 bits (145), Expect = 4e-09
Identities = 92/486 (18%), Positives = 208/486 (42%), Gaps = 74/486 (15%)
Query: 5 IITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRN---EMMTMTESYEQEKYT 61
++ + +L E++ E L+AAQ + L +L K RN E++ E+ +E
Sbjct: 1456 VLAEWKQKLDESQAE-LEAAQ------KESRSLSTELFKMRNAYEEVVDQLETLRRENKN 1508
Query: 62 LQREV-ELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVEL 120
LQ E+ +L ++ E+ EA K ++ + EK + Q++ + E++ +E + ++
Sbjct: 1509 LQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVA------LEEVEGSLEHEESKI 1562
Query: 121 DEARLSEKQLKHQVDHQ-------------------KELLSCKSEELRVMSE--RVQESM 159
+L Q+K ++D + + L S E+R ++ R+++ M
Sbjct: 1563 LRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKM 1622
Query: 160 SSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEA 219
++ ++I+L ++ + +Q + + +L + + +R + LKE+ E+
Sbjct: 1623 EGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRN 1682
Query: 220 VSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAE---VEDRRAAMERQLISMK 276
LE+ +VA + + + Q+ LD + + L ++ + + + +E + +
Sbjct: 1683 GLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQ 1742
Query: 277 VKYQSLKKQNVFNREQMQRMKLQIATLL--QMKGSQTEFEQQERLLAMLEQKNGEIKHLL 334
+ ++ Q N E+ + + A ++ ++K Q ER+ LEQ +++H L
Sbjct: 1743 AEVEN-SIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1801
Query: 335 GEI---------RNLEKFKNLYDSMESKPSVD--------------SGTLEDNTYYTD-- 369
E + ++K +N +E++ V+ +++ TY +
Sbjct: 1802 DEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEED 1861
Query: 370 -----LLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESEN 424
LQ +D L +++S K + +A + R ++ +L ++ES+
Sbjct: 1862 HKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQV 1921
Query: 425 MKLRAK 430
KLRAK
Sbjct: 1922 NKLRAK 1927
Score = 47.8 bits (112), Expect = 3e-05
Identities = 57/284 (20%), Positives = 121/284 (42%), Gaps = 16/284 (5%)
Query: 20 RLKAAQYGLQ-LVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQ---REVELKSRMLES 75
+LK +Q L + S +L+ QL + E E+ K L+ R L + L
Sbjct: 1653 QLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLD 1712
Query: 76 LSCECEAIKQQQKMHL---EKLEEQLSRSHGQ---EVNELKTKIEKLKVELDEARLSEKQ 129
S + + Q + +KLE +++ + + E + EK K + +A + ++
Sbjct: 1713 ASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEE 1772
Query: 130 LKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQY 189
LK + D L K + + + +E LAL+ +++ ++ ++E NEL
Sbjct: 1773 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDV 1832
Query: 190 RQEQLELLITNLMRQVDRLKE---EKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQ 246
Q++ + + ++KE + EE K + + ++K + + + Q ++A +Q
Sbjct: 1833 EQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892
Query: 247 ALDPNSKGNSLFAEVE---DRRAAMERQLISMKVKYQSLKKQNV 287
A S+ + E+E +R E Q+ ++ K + + Q +
Sbjct: 1893 ANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKM 1936
>gi|109134347 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 76.6 bits (187), Expect = 6e-14
Identities = 121/532 (22%), Positives = 225/532 (42%), Gaps = 78/532 (14%)
Query: 9 LRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVEL 68
LRC +A + LKA LQ +LQN+L NE T E + L+ E+
Sbjct: 40 LRCEHHKANYQTLKAEHTRLQ--NEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE 97
Query: 69 KSRMLESLSCECEAIKQQQKMHL--EKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLS 126
K++ LE + + I QK+ L +++++L + L ++EK + ++ R
Sbjct: 98 KTKDLEEMKLQ---ILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYE 154
Query: 127 EKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNE 186
LK + +HQKE E R++ E + ES L+E+ E
Sbjct: 155 HTFLKSEFEHQKE------EYARILDE---------------GKIKYESEIARLEEDKEE 193
Query: 187 LQYRQEQLELLITNLMRQVDRLKEEKEE--REKEAVSYYNALEKARVANQDLQVQLDQAL 244
L R + L + +T ++V++L EK ++ + + A KA N + QV+ Q +
Sbjct: 194 L--RNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRI 251
Query: 245 Q--QALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIAT 302
Q Q + + SL AE + ER ++ + QS +QN F ++ + + +I T
Sbjct: 252 QVRQLAEMQATVRSLEAEKQSANLRAER----LEKELQSSSEQNTFLINKLHKAEREINT 307
Query: 303 LLQMKGSQTEFEQQERL-LAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTL 361
L E + +L + ++ + K L RN K ++ D ++S + +
Sbjct: 308 L---SSKVKELKHSNKLEITDIKLETARAKSELERERN--KIQSELDGLQSDNEILKAAV 362
Query: 362 EDNTYYTDLLQMKLDNLNKEIESTKGE-------------------LSIQRMKALFESQR 402
E ++ LL K L +++++ K E +++MK + R
Sbjct: 363 E---HHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWR 419
Query: 403 ALD---IERKLFANERCLQLSESENMKLRAKLDE--LKLKYEPEETVEVPVLKKRREVLP 457
+ E KL A++ +++ E +R KL + + ++ +E E LK++ L
Sbjct: 420 QSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQ 479
Query: 458 VDIT----TAKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSV 505
+ +T + D +N L V RL K+E ++ + E L+ EK++
Sbjct: 480 IQVTSLAQSENDLLNSNQMLKEMVERL---KQECRNFRSQAEKAQLEAEKTL 528
Score = 61.2 bits (147), Expect = 3e-09
Identities = 89/418 (21%), Positives = 182/418 (43%), Gaps = 52/418 (12%)
Query: 14 KEAEEERLKAAQ--YGLQLVESQN-----ELQNQLDKCRNEMMT--MTESYEQEKYTLQR 64
KE E +++ AQ QL E Q E + Q R E + + S EQ + + +
Sbjct: 238 KENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINK 297
Query: 65 EVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEAR 124
+ R + +LS + + +K K+ + ++ + +R+ +EL+ + K++ ELD +
Sbjct: 298 -LHKAEREINTLSSKVKELKHSNKLEITDIKLETARAK----SELERERNKIQSELDGLQ 352
Query: 125 LSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTL-KEE 183
+ LK V+H K LL K EL + +E +++ LQ E E+E+ L K +
Sbjct: 353 SDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMK 412
Query: 184 VNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQA 243
V +RQ EK++ E++ + A E R Q ++++L Q
Sbjct: 413 VEHDVWRQ------------------SEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQ 454
Query: 244 LQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATL 303
+ ++ K + ++++ + ++++ Q+ S+ L N +E ++R+K +
Sbjct: 455 I-VTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNF 513
Query: 304 -LQMKGSQTEFEQ--QERLLAMLEQKNGEIKHLLGEIRNL----EKFKNLYDSMESKPSV 356
Q + +Q E E+ +E+ + LE+K+ + + EK + + + + S+
Sbjct: 514 RSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSL 573
Query: 357 DSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFE-----SQRALDIERK 409
L+ ++L+ K + L E + + R FE +R DI+R+
Sbjct: 574 HENKLKRLQEKVEVLEAKKEELETENQ------VLNRQNVPFEDYTRLQKRLKDIQRR 625
>gi|109134355 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 76.6 bits (187), Expect = 6e-14
Identities = 121/532 (22%), Positives = 225/532 (42%), Gaps = 78/532 (14%)
Query: 9 LRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVEL 68
LRC +A + LKA LQ +LQN+L NE T E + L+ E+
Sbjct: 40 LRCEHHKANYQTLKAEHTRLQ--NEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE 97
Query: 69 KSRMLESLSCECEAIKQQQKMHL--EKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLS 126
K++ LE + + I QK+ L +++++L + L ++EK + ++ R
Sbjct: 98 KTKDLEEMKLQ---ILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYE 154
Query: 127 EKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNE 186
LK + +HQKE E R++ E + ES L+E+ E
Sbjct: 155 HTFLKSEFEHQKE------EYARILDE---------------GKIKYESEIARLEEDKEE 193
Query: 187 LQYRQEQLELLITNLMRQVDRLKEEKEE--REKEAVSYYNALEKARVANQDLQVQLDQAL 244
L R + L + +T ++V++L EK ++ + + A KA N + QV+ Q +
Sbjct: 194 L--RNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRI 251
Query: 245 Q--QALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIAT 302
Q Q + + SL AE + ER ++ + QS +QN F ++ + + +I T
Sbjct: 252 QVRQLAEMQATVRSLEAEKQSANLRAER----LEKELQSSSEQNTFLINKLHKAEREINT 307
Query: 303 LLQMKGSQTEFEQQERL-LAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTL 361
L E + +L + ++ + K L RN K ++ D ++S + +
Sbjct: 308 L---SSKVKELKHSNKLEITDIKLETARAKSELERERN--KIQSELDGLQSDNEILKAAV 362
Query: 362 EDNTYYTDLLQMKLDNLNKEIESTKGE-------------------LSIQRMKALFESQR 402
E ++ LL K L +++++ K E +++MK + R
Sbjct: 363 E---HHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWR 419
Query: 403 ALD---IERKLFANERCLQLSESENMKLRAKLDE--LKLKYEPEETVEVPVLKKRREVLP 457
+ E KL A++ +++ E +R KL + + ++ +E E LK++ L
Sbjct: 420 QSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQ 479
Query: 458 VDIT----TAKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSV 505
+ +T + D +N L V RL K+E ++ + E L+ EK++
Sbjct: 480 IQVTSLAQSENDLLNSNQMLKEMVERL---KQECRNFRSQAEKAQLEAEKTL 528
Score = 61.2 bits (147), Expect = 3e-09
Identities = 89/418 (21%), Positives = 182/418 (43%), Gaps = 52/418 (12%)
Query: 14 KEAEEERLKAAQ--YGLQLVESQN-----ELQNQLDKCRNEMMT--MTESYEQEKYTLQR 64
KE E +++ AQ QL E Q E + Q R E + + S EQ + + +
Sbjct: 238 KENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINK 297
Query: 65 EVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEAR 124
+ R + +LS + + +K K+ + ++ + +R+ +EL+ + K++ ELD +
Sbjct: 298 -LHKAEREINTLSSKVKELKHSNKLEITDIKLETARAK----SELERERNKIQSELDGLQ 352
Query: 125 LSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTL-KEE 183
+ LK V+H K LL K EL + +E +++ LQ E E+E+ L K +
Sbjct: 353 SDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMK 412
Query: 184 VNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQA 243
V +RQ EK++ E++ + A E R Q ++++L Q
Sbjct: 413 VEHDVWRQ------------------SEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQ 454
Query: 244 LQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATL 303
+ ++ K + ++++ + ++++ Q+ S+ L N +E ++R+K +
Sbjct: 455 I-VTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNF 513
Query: 304 -LQMKGSQTEFEQ--QERLLAMLEQKNGEIKHLLGEIRNL----EKFKNLYDSMESKPSV 356
Q + +Q E E+ +E+ + LE+K+ + + EK + + + + S+
Sbjct: 514 RSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSL 573
Query: 357 DSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFE-----SQRALDIERK 409
L+ ++L+ K + L E + + R FE +R DI+R+
Sbjct: 574 HENKLKRLQEKVEVLEAKKEELETENQ------VLNRQNVPFEDYTRLQKRLKDIQRR 625
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.324
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,209,283
Number of Sequences: 37866
Number of extensions: 908064
Number of successful extensions: 13000
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 357
Number of HSP's successfully gapped in prelim test: 1133
Number of HSP's that attempted gapping in prelim test: 5029
Number of HSP's gapped (non-prelim): 4501
length of query: 605
length of database: 18,247,518
effective HSP length: 108
effective length of query: 497
effective length of database: 14,157,990
effective search space: 7036521030
effective search space used: 7036521030
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.