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Search of human proteins with 110431370
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110431370 espin [Homo sapiens]
(854 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110431370 espin [Homo sapiens] 1754 0.0
gi|155969701 espin-like [Homo sapiens] 377 e-104
gi|239752630 PREDICTED: hypothetical protein XP_002347769 [Homo ... 159 8e-39
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 139 1e-32
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 133 8e-31
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 133 8e-31
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 133 8e-31
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 133 8e-31
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 133 8e-31
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 132 2e-30
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 132 2e-30
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 132 2e-30
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 123 6e-28
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 122 1e-27
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 122 1e-27
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 121 3e-27
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 120 7e-27
gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens] 119 1e-26
gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens] 119 1e-26
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 117 5e-26
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 116 1e-25
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 115 2e-25
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 115 2e-25
gi|50511945 cajalin 2 isoform a [Homo sapiens] 110 6e-24
gi|34304381 inversin isoform a [Homo sapiens] 109 1e-23
gi|34304379 inversin isoform b [Homo sapiens] 109 1e-23
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 108 2e-23
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 106 8e-23
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 106 8e-23
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 105 1e-22
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 1754 bits (4544), Expect = 0.0
Identities = 854/854 (100%), Positives = 854/854 (100%)
Query: 1 MALEQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAA 60
MALEQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAA
Sbjct: 1 MALEQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAA 60
Query: 61 LPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVV 120
LPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVV
Sbjct: 61 LPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVV 120
Query: 121 NWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLAC 180
NWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLAC
Sbjct: 121 NWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLAC 180
Query: 181 QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDG 240
QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDG
Sbjct: 181 QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDG 240
Query: 241 ATAMHFAASRGHTKVLSWLLLHGGEISADLWGGTPLHDAAENGELECCQILVVNGAELDV 300
ATAMHFAASRGHTKVLSWLLLHGGEISADLWGGTPLHDAAENGELECCQILVVNGAELDV
Sbjct: 241 ATAMHFAASRGHTKVLSWLLLHGGEISADLWGGTPLHDAAENGELECCQILVVNGAELDV 300
Query: 301 RDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTT 360
RDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTT
Sbjct: 301 RDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTT 360
Query: 361 VSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQHPPCGLSSARAADIQSYMDMLNPELGL 420
VSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQHPPCGLSSARAADIQSYMDMLNPELGL
Sbjct: 361 VSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQHPPCGLSSARAADIQSYMDMLNPELGL 420
Query: 421 PRGTIGKPTPPPPPPSFPPPPPPPGTQLPPPPPGYPAPKPPVGPQAADIYMQTKNKLRHV 480
PRGTIGKPTPPPPPPSFPPPPPPPGTQLPPPPPGYPAPKPPVGPQAADIYMQTKNKLRHV
Sbjct: 421 PRGTIGKPTPPPPPPSFPPPPPPPGTQLPPPPPGYPAPKPPVGPQAADIYMQTKNKLRHV 480
Query: 481 ETEALKKELSSCDGHDGLRRQDSSRKPRAFSKQPSTGDYYRQLGRCPGETLAARPGMAHS 540
ETEALKKELSSCDGHDGLRRQDSSRKPRAFSKQPSTGDYYRQLGRCPGETLAARPGMAHS
Sbjct: 481 ETEALKKELSSCDGHDGLRRQDSSRKPRAFSKQPSTGDYYRQLGRCPGETLAARPGMAHS 540
Query: 541 EEVRARQPARAGCPRLGPAARGSLEGPSAPPQAALLPGNHVPNGCAADPKASRELPPPPP 600
EEVRARQPARAGCPRLGPAARGSLEGPSAPPQAALLPGNHVPNGCAADPKASRELPPPPP
Sbjct: 541 EEVRARQPARAGCPRLGPAARGSLEGPSAPPQAALLPGNHVPNGCAADPKASRELPPPPP 600
Query: 601 PPPPPLPEAASSPPPAPPLPLESAGPGCGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIK 660
PPPPPLPEAASSPPPAPPLPLESAGPGCGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIK
Sbjct: 601 PPPPPLPEAASSPPPAPPLPLESAGPGCGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIK 660
Query: 661 AGKSLKPTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSL 720
AGKSLKPTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSL
Sbjct: 661 AGKSLKPTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSL 720
Query: 721 VPVPPTTPAPGVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEEEE 780
VPVPPTTPAPGVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEEEE
Sbjct: 721 VPVPPTTPAPGVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEEEE 780
Query: 781 ARLASMPAWRRDLLRKKLEEEREQKRKEEERQKQEELRREKEQSEKLRTLGYDESKLAPW 840
ARLASMPAWRRDLLRKKLEEEREQKRKEEERQKQEELRREKEQSEKLRTLGYDESKLAPW
Sbjct: 781 ARLASMPAWRRDLLRKKLEEEREQKRKEEERQKQEELRREKEQSEKLRTLGYDESKLAPW 840
Query: 841 QRQVILKKGDIAKY 854
QRQVILKKGDIAKY
Sbjct: 841 QRQVILKKGDIAKY 854
>gi|155969701 espin-like [Homo sapiens]
Length = 1005
Score = 377 bits (967), Expect = e-104
Identities = 185/327 (56%), Positives = 233/327 (71%), Gaps = 1/327 (0%)
Query: 1 MALEQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAA 60
M ++AL AA+ G++ L L AG LGP + D L A VHHA RAG L C++FLV+ A
Sbjct: 1 MEKQRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQ 60
Query: 61 LPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVV 120
LP RA NGATPAHDA+ATG LA L WL+ +GGC +QD+D SG + LHLAARFGHP +V
Sbjct: 61 LPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLV 120
Query: 121 NWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLAC 180
WLLH G T T GA P+H+AA GD L+LL + VN +T++GA+PLYLAC
Sbjct: 121 EWLLHEGHS-ATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLAC 179
Query: 181 QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDG 240
QEGHL + Q+LV++CGAD H RA DGM+ LHAAA GH ++VWLV+ TD+ L+ +D +G
Sbjct: 180 QEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEG 239
Query: 241 ATAMHFAASRGHTKVLSWLLLHGGEISADLWGGTPLHDAAENGELECCQILVVNGAELDV 300
ATA+HFAA GHT +L LLL G I D WGGTPLHDAAENG++ECCQ LV + + +
Sbjct: 240 ATALHFAARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSL 299
Query: 301 RDRDGYTAADLSDFNGHSHCTRYLRTV 327
RD DGYTAADL++++GH C +YLR V
Sbjct: 300 RDEDGYTAADLAEYHGHRDCAQYLREV 326
Score = 97.8 bits (242), Expect = 4e-20
Identities = 100/382 (26%), Positives = 154/382 (40%), Gaps = 45/382 (11%)
Query: 110 LAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQT 169
+AA+ G + LL G P +GA +H+A G ++ LV+ N +
Sbjct: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
Query: 170 KNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCT 229
NGATP + A G L +LV+E G + G++PLH AA+ GH ++ WL+
Sbjct: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLH-E 126
Query: 230 DVSLSEQDKDGATAMHFAASRGHTKVLSWLLL-HGGEISADLWGG-TPLHDAAENGELEC 287
S + + ++GA +H AA G L L HG ++ G +PL+ A + G L
Sbjct: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
Query: 288 CQILVVN-GAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELE 346
Q LV + GA++ +R DG +A + GH +L T ++ + +RD
Sbjct: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIG----LTARDNEGATA 242
Query: 347 AKQPDSGMSSP---NTTVSVQPLNFDLSSPT-----STLSNYDSCSS--SHSSIKGQHPP 396
G +P + P+ D T + + C + SH
Sbjct: 243 LHFAARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDE 302
Query: 397 CGLSSARAADIQSYMDMLNPELGLPRGTIGKPTP---PPPPPSFPPPP------------ 441
G ++A A+ + D + +P P PPPP FPPPP
Sbjct: 303 DGYTAADLAEYHGHRDCAQ-----YLREVAQPVPLLMTPPPPPFPPPPLLATRRSLEDGR 357
Query: 442 ---PPPGTQLP----PPPPGYP 456
P PG P P PG+P
Sbjct: 358 RGGPGPGNPSPMSLSPAWPGHP 379
Score = 69.3 bits (168), Expect = 1e-11
Identities = 67/229 (29%), Positives = 84/229 (36%), Gaps = 60/229 (26%)
Query: 573 AALLPGNHVPNGCA------ADPKASRELPPPPPPPPPPLPEAASSPPPAPPLPLESAGP 626
AA L H CA A P PPPPP PPPPL S GP
Sbjct: 307 AADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPPPLLATRRSLEDG-----RRGGP 361
Query: 627 GCGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGIGQPAF 686
G G P+P S L+ + G
Sbjct: 362 GPGN------------------------------------PSPMS--LSPAWPG------ 377
Query: 687 QPDSPLPS---VSPALSPV-RSPTPPAAGFQPLLNGSLVPVPPTTPAPGVQL-DVEALIP 741
PD PLP SPA + S T G + L G G+ D++ L+P
Sbjct: 378 HPDQPLPREQMTSPAPPRIITSATADPEGTETALAGDTSDGLAALQLDGLPSGDIDGLVP 437
Query: 742 THDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEEEEARLASMPAWR 790
T DE+G+PIPEWKRQVMVRK+Q ++ E ++ + AWR
Sbjct: 438 TRDERGQPIPEWKRQVMVRKLQARLGAESSAEAQDNGGSSGPTEQAAWR 486
>gi|239752630 PREDICTED: hypothetical protein XP_002347769 [Homo
sapiens]
Length = 127
Score = 159 bits (403), Expect = 8e-39
Identities = 76/80 (95%), Positives = 78/80 (97%)
Query: 207 MTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEI 266
MTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATA HFAASRGH+KVLSWLLLHGGEI
Sbjct: 1 MTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHGGEI 60
Query: 267 SADLWGGTPLHDAAENGELE 286
SADLWGGT L+DAAENGELE
Sbjct: 61 SADLWGGTALYDAAENGELE 80
Score = 57.8 bits (138), Expect = 4e-08
Identities = 30/79 (37%), Positives = 43/79 (54%), Gaps = 2/79 (2%)
Query: 72 TPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDP 131
TP H A+ GH + WL+S + ++D GAT H AA GH +V++WLL HGG
Sbjct: 2 TPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHGG--E 59
Query: 132 TAATDMGALPIHYAAAKGD 150
+A G ++ AA G+
Sbjct: 60 ISADLWGGTALYDAAENGE 78
Score = 47.0 bits (110), Expect = 8e-05
Identities = 36/106 (33%), Positives = 50/106 (47%), Gaps = 10/106 (9%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA+ G + +LV + + + ++GAT H A++ GH L WLL GG
Sbjct: 3 PLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHGG--EI 60
Query: 99 DKDNSGATVLHLAARFGHPEV---VNWLLHHGGGDPTAATDMGALP 141
D G T L+ AA G EV W G P+A T + A P
Sbjct: 61 SADLWGGTALYDAAENGELEVSAGPGW-----GRAPSAGTALSARP 101
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/83 (36%), Positives = 42/83 (50%), Gaps = 2/83 (2%)
Query: 106 TVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGV 165
T LH AA+ GH V+ WL+ + GA H+AA++G L L+ H E +
Sbjct: 2 TPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHGGE-I 60
Query: 166 NAQTKNGATPLYLACQEGHLEVT 188
+A G T LY A + G LEV+
Sbjct: 61 SADLWGG-TALYDAAENGELEVS 82
Score = 37.0 bits (84), Expect = 0.078
Identities = 27/81 (33%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 141 PIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPH 200
P+H AA G P + LV ++ Q K+GAT + A GH +V +L+ G +
Sbjct: 3 PLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLH-GGEIS 61
Query: 201 ARAHDGMTPLHAAAQMGHSPV 221
A G T L+ AA+ G V
Sbjct: 62 ADLWGG-TALYDAAENGELEV 81
Score = 32.0 bits (71), Expect = 2.5
Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 4/60 (6%)
Query: 242 TAMHFAASRGHTKVLSWLLLHGGEISA---DLWGGTPLHDAAENGELECCQILVVNGAEL 298
T +H AA GH+ V+ WL+ ++S D G T H AA G + L+++G E+
Sbjct: 2 TPLHAAAQMGHSPVIVWLV-SCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHGGEI 60
Score = 30.0 bits (66), Expect = 9.5
Identities = 19/52 (36%), Positives = 24/52 (46%), Gaps = 1/52 (1%)
Query: 274 TPLHDAAENGELECCQILV-VNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
TPLH AA+ G LV L +D+DG TA + GHS +L
Sbjct: 2 TPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWL 53
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 139 bits (349), Expect = 1e-32
Identities = 100/318 (31%), Positives = 158/318 (49%), Gaps = 10/318 (3%)
Query: 9 AARQGELDVLRSLHAAGL-LGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
AAR G+ +V+R L G + +D D P+H +AR GK ++ L+++ A P AA
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKD--DQTPLHISARLGKADIVQQLLQQGASPNAATT 530
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
+G TP H ++ GH +LL G + G T LH+AA++G EV N LL
Sbjct: 531 -SGYTPLHLSAREGHEDVAAFLLDHGAS-LSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588
Query: 128 GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEV 187
P AA G P+H AA D + LL+ +A KNG TPL++A ++ +++
Sbjct: 589 AS-PDAAGKSGLTPLH-VAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDI 646
Query: 188 TQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFA 247
L+ E GAD +A G+ +H AAQ GH ++ L+ + +++ +K G T +H A
Sbjct: 647 ATTLL-EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLG-RNANVNLSNKSGLTPLHLA 704
Query: 248 ASRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGY 306
A V L+ G + A G TPLH G ++ L+ + A+++ + ++GY
Sbjct: 705 AQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGY 764
Query: 307 TAADLSDFNGHSHCTRYL 324
T + GH+H L
Sbjct: 765 TPLHQAAQQGHTHIINVL 782
Score = 138 bits (348), Expect = 2e-32
Identities = 99/317 (31%), Positives = 155/317 (48%), Gaps = 8/317 (2%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AA G ++++ L G P+ + +H AAR+G+ +R+LV++ A A+A+
Sbjct: 440 AAFMGHVNIVSQLMHHGA-SPNTTNVRGETALHMAARSGQAEVVRYLVQDGA-QVEAKAK 497
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
+ TP H ++ G +Q LL QG SG T LHL+AR GH +V +LL HG
Sbjct: 498 DDQTPLHISARLGKADIVQQLLQQGASP-NAATTSGYTPLHLSAREGHEDVAAFLLDHGA 556
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+ T G P+H AA G LL++ +A K+G TPL++A + +V
Sbjct: 557 S-LSITTKKGFTPLHVAAKYGKLEVANLLLQK-SASPDAAGKSGLTPLHVAAHYDNQKVA 614
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
L+ + GA PHA A +G TPLH AA+ + L+ + + G ++H AA
Sbjct: 615 LLLLDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEY-GADANAVTRQGIASVHLAA 672
Query: 249 SRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
GH ++S LL ++ G TPLH AA+ + ++LV GA +D + + GYT
Sbjct: 673 QEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYT 732
Query: 308 AADLSDFNGHSHCTRYL 324
+ G+ +L
Sbjct: 733 PLHVGCHYGNIKIVNFL 749
Score = 130 bits (328), Expect = 4e-30
Identities = 92/269 (34%), Positives = 135/269 (50%), Gaps = 7/269 (2%)
Query: 40 VHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQD 99
+H AA G + L+++ A P A +A NG TP H A + ++ LL G +Q
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKANPNA-KALNGFTPLHIACKKNRIKVMELLLKHGAS-IQA 428
Query: 100 KDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVE 159
SG T +H+AA GH +V+ L+HH G P G +H AA G +R LV+
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHH-GASPNTTNVRGETALHMAARSGQAEVVRYLVQ 487
Query: 160 HYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHS 219
+ V A+ K+ TPL+++ + G ++ Q L+Q+ GA P+A G TPLH +A+ GH
Sbjct: 488 DGAQ-VEAKAKDDQTPLHISARLGKADIVQQLLQQ-GASPNAATTSGYTPLHLSAREGHE 545
Query: 220 PVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGE-ISADLWGGTPLHD 278
V +L+ SLS K G T +H AA G +V + LL +A G TPLH
Sbjct: 546 DVAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
Query: 279 AAENGELECCQILVVNGAELDVRDRDGYT 307
AA + +L+ GA ++GYT
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYT 633
Score = 115 bits (287), Expect = 2e-25
Identities = 86/278 (30%), Positives = 126/278 (45%), Gaps = 35/278 (12%)
Query: 77 ASATGHLA-CLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAAT 135
A+ GHL L ++ + G + + +G LHLA++ GH EVV+ LL + AAT
Sbjct: 48 AARAGHLEKALDYI--KNGVDINICNQNGLNALHLASKEGHVEVVSELLQREA-NVDAAT 104
Query: 136 DMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQEC 195
G +H A+ G +++LV + VNAQ++NG TPLY+A QE HLEV ++L+
Sbjct: 105 KKGNTALHIASLAGQAEVVKVLVTN-GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDN- 162
Query: 196 GADPHARAHDGMTPLHAAAQMGHSPVIVWLVS---------------------------- 227
GA DG TPL A Q GH V+ L+
Sbjct: 163 GASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLL 222
Query: 228 CTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELE 286
D + + K G T +H AA G+ V + LL + TPLH A++ G
Sbjct: 223 QNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNAN 282
Query: 287 CCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
++L+ GA++D + RDG T +GH L
Sbjct: 283 MVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320
Score = 110 bits (275), Expect = 6e-24
Identities = 83/286 (29%), Positives = 143/286 (50%), Gaps = 11/286 (3%)
Query: 40 VHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQD 99
+H A+ AG+ ++ LV A A+++NG TP + A+ HL +++LL G +
Sbjct: 111 LHIASLAGQAEVVKVLVTNGA-NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLA 169
Query: 100 KDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVE 159
++ G T L +A + GH +VV+ LL + D + AL H AA K D + LL++
Sbjct: 170 TED-GFTPLAVALQQGHDQVVSLLLEN---DTKGKVRLPAL--HIAARKDDTKAAALLLQ 223
Query: 160 HYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHS 219
+ + ++K+G TPL++A G++ V L+ A +D +TPLH A++ G++
Sbjct: 224 N-DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND-ITPLHVASKRGNA 281
Query: 220 PVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLHD 278
++ L+ + + +DG T +H A GH +V+ LL I + G +PLH
Sbjct: 282 NMVKLLLD-RGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHM 340
Query: 279 AAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
A + L C Q+L+ + +D D TA ++ GH + L
Sbjct: 341 ATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
Score = 105 bits (262), Expect = 2e-22
Identities = 88/309 (28%), Positives = 149/309 (48%), Gaps = 36/309 (11%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLL---SQGGC 95
P++ AA+ L ++FL++ A + A +G TP A GH + LL ++G
Sbjct: 143 PLYMAAQENHLEVVKFLLDNGASQSLA-TEDGFTPLAVALQQGHDQVVSLLLENDTKGKV 201
Query: 96 RV-------------------QDKDN------SGATVLHLAARFGHPEVVNWLLHHGGG- 129
R+ Q+ +N SG T LH+AA +G+ V LL+
Sbjct: 202 RLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAV 261
Query: 130 DPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQ 189
D TA D+ P+H A+ +G+ ++LL++ + ++A+T++G TPL+ + GH +V +
Sbjct: 262 DFTARNDI--TPLHVASKRGNANMVKLLLDRGAK-IDAKTRDGLTPLHCGARSGHEQVVE 318
Query: 190 YLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAAS 249
L+ A ++ +G++PLH A Q H + L+ +V + + D TA+H AA
Sbjct: 319 MLLDRA-APILSKTKNGLSPLHMATQGDHLNCVQLLLQ-HNVPVDDVTNDYLTALHVAAH 376
Query: 250 RGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDGYTA 308
GH KV LL +A G TPLH A + ++ ++L+ +GA + G T
Sbjct: 377 CGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTP 436
Query: 309 ADLSDFNGH 317
++ F GH
Sbjct: 437 IHVAAFMGH 445
Score = 100 bits (250), Expect = 4e-21
Identities = 83/286 (29%), Positives = 132/286 (46%), Gaps = 7/286 (2%)
Query: 40 VHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQD 99
+H AAR L++ A +++G TP H A+ G++ LL++ V
Sbjct: 206 LHIAARKDDTKAAALLLQNDN-NADVESKSGFTPLHIAAHYGNINVATLLLNRAAA-VDF 263
Query: 100 KDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVE 159
+ T LH+A++ G+ +V LL G D G P+H A G + +L++
Sbjct: 264 TARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD-GLTPLHCGARSGHEQVVEMLLD 322
Query: 160 HYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHS 219
+ ++TKNG +PL++A Q HL Q L+Q +D +T LH AA GH
Sbjct: 323 RAAP-ILSKTKNGLSPLHMATQGDHLNCVQLLLQH-NVPVDDVTNDYLTALHVAAHCGHY 380
Query: 220 PVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLHD 278
V L+ + + + +G T +H A + KV+ LL HG I A G TP+H
Sbjct: 381 KVAKVLLD-KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHV 439
Query: 279 AAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
AA G + L+ +GA + + G TA ++ +G + RYL
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Score = 88.6 bits (218), Expect = 2e-17
Identities = 64/196 (32%), Positives = 98/196 (50%), Gaps = 5/196 (2%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA+ ++ L+E A A A R G H A+ GH+ + LL + V
Sbjct: 634 PLHIAAKKNQMDIATTLLEYGA-DANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA-NVN 691
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
+ SG T LHLAA+ V L++ G A T MG P+H G+ + L+
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNVAEVLVNQGA-HVDAQTKMGYTPLHVGCHYGNIKIVNFLL 750
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
+H + VNA+TKNG TPL+ A Q+GH + L+Q A P+ +G T L A ++G+
Sbjct: 751 QHSAK-VNAKTKNGYTPLHQAAQQGHTHIINVLLQN-NASPNELTVNGNTALGIARRLGY 808
Query: 219 SPVIVWLVSCTDVSLS 234
V+ L T+ +++
Sbjct: 809 ISVVDTLKIVTEETMT 824
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 133 bits (334), Expect = 8e-31
Identities = 106/352 (30%), Positives = 169/352 (48%), Gaps = 14/352 (3%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AAR G ++++ L P+L P+H AAR G + + L+E+ A A +
Sbjct: 510 AARIGHTNMVKLL-LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA-SQACMTK 567
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G TP H A+ G + + LL + +G T LH+A + ++V LL GG
Sbjct: 568 KGFTPLHVAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+ A + G P+H AA + R L++ Y NA++ G TPL+LA QEGH E+
Sbjct: 627 SPHSPAWN-GYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMV 684
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
L+ + A+ + G+TPLH AQ GH PV L+ V + + G T +H A+
Sbjct: 685 ALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVAS 742
Query: 249 SRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
G+ K++ +LL H +++A G +PLH AA+ G + +L+ NGA + DG T
Sbjct: 743 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 802
Query: 308 AADLSDFNGHSHCTRYLRTVEN------LSVEHRVLSRDPSAELEAKQPDSG 353
++ G+ T L+ V + +S +HR+ + E+ D G
Sbjct: 803 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG 854
Score = 130 bits (327), Expect = 5e-30
Identities = 98/314 (31%), Positives = 156/314 (49%), Gaps = 14/314 (4%)
Query: 9 AARQGELDVLRSL-HAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
AAR G +V + L + +D D P+H AAR G + ++ L+E A P A
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKD--DQTPLHCAARIGHTNMVKLLLENNANPNLATT 534
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
G TP H A+ GH+ + LL + + G T LH+AA++G V LL
Sbjct: 535 A-GHTPLHIAAREGHVETVLALLEKEASQA-CMTKKGFTPLHVAAKYGKVRVAELLLER- 591
Query: 128 GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTK--NGATPLYLACQEGHL 185
P AA G P+H A + ++LL+ P G + + NG TPL++A ++ +
Sbjct: 592 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL---PRGGSPHSPAWNGYTPLHIAAKQNQV 648
Query: 186 EVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMH 245
EV + L+Q G +A + G+TPLH AAQ GH+ ++ L+S + + +K G T +H
Sbjct: 649 EVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKSGLTPLH 706
Query: 246 FAASRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRD 304
A GH V L+ HG + A G TPLH A+ G ++ + L+ + A+++ + +
Sbjct: 707 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 766
Query: 305 GYTAADLSDFNGHS 318
GY+ + GH+
Sbjct: 767 GYSPLHQAAQQGHT 780
Score = 122 bits (307), Expect = 1e-27
Identities = 85/280 (30%), Positives = 143/280 (51%), Gaps = 7/280 (2%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H A+R G + +R L++ A + ++ TP H A+ GH+ + LL G +Q
Sbjct: 275 PLHIASRRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGA-PIQ 332
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
K +G + +H+AA+ H + V LL + D P+H AA G ++L+
Sbjct: 333 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLL 391
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
+ + N++ NG TPL++AC++ H+ V + L++ GA A G+TPLH A+ MGH
Sbjct: 392 DKGAKP-NSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGH 449
Query: 219 SPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLH 277
P++ L+ S + + T +H AA GHT+V +LL + +++A TPLH
Sbjct: 450 LPIVKNLLQ-RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 508
Query: 278 DAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGH 317
AA G ++L+ N A ++ G+T ++ GH
Sbjct: 509 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 548
Score = 117 bits (292), Expect = 6e-26
Identities = 91/319 (28%), Positives = 141/319 (44%), Gaps = 38/319 (11%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA G + L+++ A P + RA NG TP H A H+ ++ LL + G +
Sbjct: 374 PLHVAAHCGHHRVAKVLLDKGAKPNS-RALNGFTPLHIACKKNHVRVME-LLLKTGASID 431
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
SG T LH+A+ GH +V LL G P + P+H AA G + L+
Sbjct: 432 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 490
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
++ + VNA+ K+ TPL+ A + GH + + L+ E A+P+ G TPLH AA+ GH
Sbjct: 491 QNKAK-VNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGH 548
Query: 219 SPVIVWLV------SC--------------------------TDVSLSEQDKDGATAMHF 246
++ L+ +C D + K+G T +H
Sbjct: 549 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 608
Query: 247 AASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDG 305
A + ++ LL GG + W G TPLH AA+ ++E + L+ G + G
Sbjct: 609 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668
Query: 306 YTAADLSDFNGHSHCTRYL 324
T L+ GH+ L
Sbjct: 669 VTPLHLAAQEGHAEMVALL 687
Score = 112 bits (281), Expect = 1e-24
Identities = 96/319 (30%), Positives = 157/319 (49%), Gaps = 16/319 (5%)
Query: 9 AARQGELD-VLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
A+++G + V+ LH +L + + AL H AA AG+ +R LV A A++
Sbjct: 85 ASKEGHVKMVVELLHKEIILETTTKKGNTAL--HIAALAGQDEVVRELVNYGA-NVNAQS 141
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
+ G TP + A+ HL +++LL + G G T L +A + GH VV L+++G
Sbjct: 142 QKGFTPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200
Query: 128 GGDPTAATDMGALP-IHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLE 186
LP +H AA D + +L+++ P + +K G TPL++A +L
Sbjct: 201 TKGKVR------LPALHIAARNDDTRTAAVLLQNDPNP-DVLSKTGFTPLHIAAHYENLN 253
Query: 187 VTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHF 246
V Q L+ GA + +G+TPLH A++ G+ ++V L+ + + KD T +H
Sbjct: 254 VAQLLLNR-GASVNFTPQNGITPLHIASRRGNV-IMVRLLLDRGAQIETKTKDELTPLHC 311
Query: 247 AASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDG 305
AA GH ++ LL HG I A G +P+H AA+ L+C ++L+ AE+D D
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 371
Query: 306 YTAADLSDFNGHSHCTRYL 324
T ++ GH + L
Sbjct: 372 LTPLHVAAHCGHHRVAKVL 390
Score = 110 bits (276), Expect = 4e-24
Identities = 93/311 (29%), Positives = 140/311 (45%), Gaps = 28/311 (9%)
Query: 92 QGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDF 151
+ G + + +G LHLA++ GH ++V LLH T T G +H AA G
Sbjct: 66 RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT-TKKGNTALHIAALAGQD 124
Query: 152 PSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLH 211
+R LV +Y VNAQ++ G TPLY+A QE HLEV ++L+ E GA+ + DG TPL
Sbjct: 125 EVVRELV-NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLA 182
Query: 212 AAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DL 270
A Q GH V+ L ++ + K A+H AA T+ + LL +
Sbjct: 183 VALQQGHENVVAHL-----INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237
Query: 271 WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENL 330
G TPLH AA L Q+L+ GA ++ ++G T ++ G+ R L
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL------ 291
Query: 331 SVEHRVLSRDPSAELEAKQPDS----GMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSS 386
D A++E K D ++ N V + + D +P + + S
Sbjct: 292 --------LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK-NGLSPI 342
Query: 387 HSSIKGQHPPC 397
H + +G H C
Sbjct: 343 HMAAQGDHLDC 353
Score = 109 bits (273), Expect = 9e-24
Identities = 98/317 (30%), Positives = 148/317 (46%), Gaps = 12/317 (3%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
A +QG +V+ L G G +R P +H AAR L++ P ++
Sbjct: 184 ALQQGHENVVAHLINYGTKG-KVRLPA----LHIAARNDDTRTAAVLLQNDPNPDVL-SK 237
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G TP H A+ +L Q LL++G V +G T LH+A+R G+ +V LL G
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 296
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
T D P+H AA G +L++H + A+TKNG +P+++A Q HL+
Sbjct: 297 QIETKTKDE-LTPLHCAARNGHVRISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCV 354
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
+ L+Q A+ D +TPLH AA GH V L+ + + +G T +H A
Sbjct: 355 RLLLQY-DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIAC 412
Query: 249 SRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
+ H +V+ LL G I A G TPLH A+ G L + L+ GA +V + T
Sbjct: 413 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 472
Query: 308 AADLSDFNGHSHCTRYL 324
++ GH+ +YL
Sbjct: 473 PLHMAARAGHTEVAKYL 489
Score = 99.0 bits (245), Expect = 2e-20
Identities = 79/300 (26%), Positives = 138/300 (46%), Gaps = 37/300 (12%)
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
+NG H AS GH+ + LL + ++ G T LH+AA G EVV L+++G
Sbjct: 76 QNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYG 134
Query: 128 GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEV 187
+ A + G P++ AA + ++ L+E+ N T++G TPL +A Q+GH V
Sbjct: 135 A-NVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GANQNVATEDGFTPLAVALQQGHENV 192
Query: 188 TQYLVQ----------------------------ECGADPHARAHDGMTPLHAAAQMGHS 219
+L+ + +P + G TPLH AA +
Sbjct: 193 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 252
Query: 220 PVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLHD 278
V L++ S++ ++G T +H A+ RG+ ++ LL G +I TPLH
Sbjct: 253 NVAQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 311
Query: 279 AAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTR----YLRTVENLSVEH 334
AA NG + +IL+ +GA + + ++G + ++ H C R Y +++++++H
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 371
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 133 bits (334), Expect = 8e-31
Identities = 106/352 (30%), Positives = 169/352 (48%), Gaps = 14/352 (3%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AAR G ++++ L P+L P+H AAR G + + L+E+ A A +
Sbjct: 477 AARIGHTNMVKLL-LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA-SQACMTK 534
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G TP H A+ G + + LL + +G T LH+A + ++V LL GG
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+ A + G P+H AA + R L++ Y NA++ G TPL+LA QEGH E+
Sbjct: 594 SPHSPAWN-GYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMV 651
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
L+ + A+ + G+TPLH AQ GH PV L+ V + + G T +H A+
Sbjct: 652 ALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVAS 709
Query: 249 SRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
G+ K++ +LL H +++A G +PLH AA+ G + +L+ NGA + DG T
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 308 AADLSDFNGHSHCTRYLRTVEN------LSVEHRVLSRDPSAELEAKQPDSG 353
++ G+ T L+ V + +S +HR+ + E+ D G
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG 821
Score = 130 bits (327), Expect = 5e-30
Identities = 98/314 (31%), Positives = 156/314 (49%), Gaps = 14/314 (4%)
Query: 9 AARQGELDVLRSL-HAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
AAR G +V + L + +D D P+H AAR G + ++ L+E A P A
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKD--DQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
G TP H A+ GH+ + LL + + G T LH+AA++G V LL
Sbjct: 502 A-GHTPLHIAAREGHVETVLALLEKEASQA-CMTKKGFTPLHVAAKYGKVRVAELLLER- 558
Query: 128 GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTK--NGATPLYLACQEGHL 185
P AA G P+H A + ++LL+ P G + + NG TPL++A ++ +
Sbjct: 559 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL---PRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 186 EVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMH 245
EV + L+Q G +A + G+TPLH AAQ GH+ ++ L+S + + +K G T +H
Sbjct: 616 EVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKSGLTPLH 673
Query: 246 FAASRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRD 304
A GH V L+ HG + A G TPLH A+ G ++ + L+ + A+++ + +
Sbjct: 674 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 733
Query: 305 GYTAADLSDFNGHS 318
GY+ + GH+
Sbjct: 734 GYSPLHQAAQQGHT 747
Score = 122 bits (307), Expect = 1e-27
Identities = 85/280 (30%), Positives = 143/280 (51%), Gaps = 7/280 (2%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H A+R G + +R L++ A + ++ TP H A+ GH+ + LL G +Q
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGA-PIQ 299
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
K +G + +H+AA+ H + V LL + D P+H AA G ++L+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLL 358
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
+ + N++ NG TPL++AC++ H+ V + L++ GA A G+TPLH A+ MGH
Sbjct: 359 DKGAKP-NSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGH 416
Query: 219 SPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLH 277
P++ L+ S + + T +H AA GHT+V +LL + +++A TPLH
Sbjct: 417 LPIVKNLLQ-RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
Query: 278 DAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGH 317
AA G ++L+ N A ++ G+T ++ GH
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 117 bits (292), Expect = 6e-26
Identities = 91/319 (28%), Positives = 141/319 (44%), Gaps = 38/319 (11%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA G + L+++ A P + RA NG TP H A H+ ++ LL + G +
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNS-RALNGFTPLHIACKKNHVRVME-LLLKTGASID 398
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
SG T LH+A+ GH +V LL G P + P+H AA G + L+
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
++ + VNA+ K+ TPL+ A + GH + + L+ E A+P+ G TPLH AA+ GH
Sbjct: 458 QNKAK-VNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGH 515
Query: 219 SPVIVWLV------SC--------------------------TDVSLSEQDKDGATAMHF 246
++ L+ +C D + K+G T +H
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Query: 247 AASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDG 305
A + ++ LL GG + W G TPLH AA+ ++E + L+ G + G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 306 YTAADLSDFNGHSHCTRYL 324
T L+ GH+ L
Sbjct: 636 VTPLHLAAQEGHAEMVALL 654
Score = 112 bits (281), Expect = 1e-24
Identities = 96/319 (30%), Positives = 157/319 (49%), Gaps = 16/319 (5%)
Query: 9 AARQGELD-VLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
A+++G + V+ LH +L + + AL H AA AG+ +R LV A A++
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTAL--HIAALAGQDEVVRELVNYGA-NVNAQS 108
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
+ G TP + A+ HL +++LL + G G T L +A + GH VV L+++G
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 128 GGDPTAATDMGALP-IHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLE 186
LP +H AA D + +L+++ P + +K G TPL++A +L
Sbjct: 168 TKGKVR------LPALHIAARNDDTRTAAVLLQNDPNP-DVLSKTGFTPLHIAAHYENLN 220
Query: 187 VTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHF 246
V Q L+ GA + +G+TPLH A++ G+ ++V L+ + + KD T +H
Sbjct: 221 VAQLLLNR-GASVNFTPQNGITPLHIASRRGNV-IMVRLLLDRGAQIETKTKDELTPLHC 278
Query: 247 AASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDG 305
AA GH ++ LL HG I A G +P+H AA+ L+C ++L+ AE+D D
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 306 YTAADLSDFNGHSHCTRYL 324
T ++ GH + L
Sbjct: 339 LTPLHVAAHCGHHRVAKVL 357
Score = 111 bits (277), Expect = 3e-24
Identities = 101/338 (29%), Positives = 152/338 (44%), Gaps = 31/338 (9%)
Query: 66 RARNGATPAHDASATGHL-ACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLL 124
R + AT A+ +G+L L L + G + + +G LHLA++ GH ++V LL
Sbjct: 8 READAATSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 125 HHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGH 184
H T T G +H AA G +R LV +Y VNAQ++ G TPLY+A QE H
Sbjct: 66 HKEIILETT-TKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENH 123
Query: 185 LEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAM 244
LEV ++L+ E GA+ + DG TPL A Q GH V+ L ++ + K A+
Sbjct: 124 LEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHL-----INYGTKGKVRLPAL 177
Query: 245 HFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDR 303
H AA T+ + LL + G TPLH AA L Q+L+ GA ++ +
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237
Query: 304 DGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDS----GMSSPNT 359
+G T ++ G+ R L D A++E K D ++ N
Sbjct: 238 NGITPLHIASRRGNVIMVRLL--------------LDRGAQIETKTKDELTPLHCAARNG 283
Query: 360 TVSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQHPPC 397
V + + D +P + + S H + +G H C
Sbjct: 284 HVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDC 320
Score = 109 bits (273), Expect = 9e-24
Identities = 98/317 (30%), Positives = 148/317 (46%), Gaps = 12/317 (3%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
A +QG +V+ L G G +R P +H AAR L++ P ++
Sbjct: 151 ALQQGHENVVAHLINYGTKG-KVRLPA----LHIAARNDDTRTAAVLLQNDPNPDVL-SK 204
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G TP H A+ +L Q LL++G V +G T LH+A+R G+ +V LL G
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
T D P+H AA G +L++H + A+TKNG +P+++A Q HL+
Sbjct: 264 QIETKTKDE-LTPLHCAARNGHVRISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCV 321
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
+ L+Q A+ D +TPLH AA GH V L+ + + +G T +H A
Sbjct: 322 RLLLQY-DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIAC 379
Query: 249 SRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
+ H +V+ LL G I A G TPLH A+ G L + L+ GA +V + T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 308 AADLSDFNGHSHCTRYL 324
++ GH+ +YL
Sbjct: 440 PLHMAARAGHTEVAKYL 456
Score = 99.0 bits (245), Expect = 2e-20
Identities = 79/300 (26%), Positives = 138/300 (46%), Gaps = 37/300 (12%)
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
+NG H AS GH+ + LL + ++ G T LH+AA G EVV L+++G
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 128 GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEV 187
+ A + G P++ AA + ++ L+E+ N T++G TPL +A Q+GH V
Sbjct: 102 A-NVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GANQNVATEDGFTPLAVALQQGHENV 159
Query: 188 TQYLVQ----------------------------ECGADPHARAHDGMTPLHAAAQMGHS 219
+L+ + +P + G TPLH AA +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 220 PVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLHD 278
V L++ S++ ++G T +H A+ RG+ ++ LL G +I TPLH
Sbjct: 220 NVAQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 278
Query: 279 AAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTR----YLRTVENLSVEH 334
AA NG + +IL+ +GA + + ++G + ++ H C R Y +++++++H
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 133 bits (334), Expect = 8e-31
Identities = 106/352 (30%), Positives = 169/352 (48%), Gaps = 14/352 (3%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AAR G ++++ L P+L P+H AAR G + + L+E+ A A +
Sbjct: 477 AARIGHTNMVKLL-LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA-SQACMTK 534
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G TP H A+ G + + LL + +G T LH+A + ++V LL GG
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+ A + G P+H AA + R L++ Y NA++ G TPL+LA QEGH E+
Sbjct: 594 SPHSPAWN-GYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMV 651
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
L+ + A+ + G+TPLH AQ GH PV L+ V + + G T +H A+
Sbjct: 652 ALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVAS 709
Query: 249 SRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
G+ K++ +LL H +++A G +PLH AA+ G + +L+ NGA + DG T
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 308 AADLSDFNGHSHCTRYLRTVEN------LSVEHRVLSRDPSAELEAKQPDSG 353
++ G+ T L+ V + +S +HR+ + E+ D G
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG 821
Score = 130 bits (327), Expect = 5e-30
Identities = 98/314 (31%), Positives = 156/314 (49%), Gaps = 14/314 (4%)
Query: 9 AARQGELDVLRSL-HAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
AAR G +V + L + +D D P+H AAR G + ++ L+E A P A
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKD--DQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
G TP H A+ GH+ + LL + + G T LH+AA++G V LL
Sbjct: 502 A-GHTPLHIAAREGHVETVLALLEKEASQA-CMTKKGFTPLHVAAKYGKVRVAELLLER- 558
Query: 128 GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTK--NGATPLYLACQEGHL 185
P AA G P+H A + ++LL+ P G + + NG TPL++A ++ +
Sbjct: 559 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL---PRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 186 EVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMH 245
EV + L+Q G +A + G+TPLH AAQ GH+ ++ L+S + + +K G T +H
Sbjct: 616 EVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKSGLTPLH 673
Query: 246 FAASRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRD 304
A GH V L+ HG + A G TPLH A+ G ++ + L+ + A+++ + +
Sbjct: 674 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 733
Query: 305 GYTAADLSDFNGHS 318
GY+ + GH+
Sbjct: 734 GYSPLHQAAQQGHT 747
Score = 122 bits (307), Expect = 1e-27
Identities = 85/280 (30%), Positives = 143/280 (51%), Gaps = 7/280 (2%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H A+R G + +R L++ A + ++ TP H A+ GH+ + LL G +Q
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGA-PIQ 299
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
K +G + +H+AA+ H + V LL + D P+H AA G ++L+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLL 358
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
+ + N++ NG TPL++AC++ H+ V + L++ GA A G+TPLH A+ MGH
Sbjct: 359 DKGAKP-NSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGH 416
Query: 219 SPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLH 277
P++ L+ S + + T +H AA GHT+V +LL + +++A TPLH
Sbjct: 417 LPIVKNLLQ-RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
Query: 278 DAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGH 317
AA G ++L+ N A ++ G+T ++ GH
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 117 bits (292), Expect = 6e-26
Identities = 91/319 (28%), Positives = 141/319 (44%), Gaps = 38/319 (11%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA G + L+++ A P + RA NG TP H A H+ ++ LL + G +
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNS-RALNGFTPLHIACKKNHVRVME-LLLKTGASID 398
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
SG T LH+A+ GH +V LL G P + P+H AA G + L+
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
++ + VNA+ K+ TPL+ A + GH + + L+ E A+P+ G TPLH AA+ GH
Sbjct: 458 QNKAK-VNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGH 515
Query: 219 SPVIVWLV------SC--------------------------TDVSLSEQDKDGATAMHF 246
++ L+ +C D + K+G T +H
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Query: 247 AASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDG 305
A + ++ LL GG + W G TPLH AA+ ++E + L+ G + G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 306 YTAADLSDFNGHSHCTRYL 324
T L+ GH+ L
Sbjct: 636 VTPLHLAAQEGHAEMVALL 654
Score = 112 bits (281), Expect = 1e-24
Identities = 96/319 (30%), Positives = 157/319 (49%), Gaps = 16/319 (5%)
Query: 9 AARQGELD-VLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
A+++G + V+ LH +L + + AL H AA AG+ +R LV A A++
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTAL--HIAALAGQDEVVRELVNYGA-NVNAQS 108
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
+ G TP + A+ HL +++LL + G G T L +A + GH VV L+++G
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 128 GGDPTAATDMGALP-IHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLE 186
LP +H AA D + +L+++ P + +K G TPL++A +L
Sbjct: 168 TKGKVR------LPALHIAARNDDTRTAAVLLQNDPNP-DVLSKTGFTPLHIAAHYENLN 220
Query: 187 VTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHF 246
V Q L+ GA + +G+TPLH A++ G+ ++V L+ + + KD T +H
Sbjct: 221 VAQLLLNR-GASVNFTPQNGITPLHIASRRGNV-IMVRLLLDRGAQIETKTKDELTPLHC 278
Query: 247 AASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDG 305
AA GH ++ LL HG I A G +P+H AA+ L+C ++L+ AE+D D
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 306 YTAADLSDFNGHSHCTRYL 324
T ++ GH + L
Sbjct: 339 LTPLHVAAHCGHHRVAKVL 357
Score = 111 bits (277), Expect = 3e-24
Identities = 101/338 (29%), Positives = 152/338 (44%), Gaps = 31/338 (9%)
Query: 66 RARNGATPAHDASATGHL-ACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLL 124
R + AT A+ +G+L L L + G + + +G LHLA++ GH ++V LL
Sbjct: 8 READAATSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 125 HHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGH 184
H T T G +H AA G +R LV +Y VNAQ++ G TPLY+A QE H
Sbjct: 66 HKEIILETT-TKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENH 123
Query: 185 LEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAM 244
LEV ++L+ E GA+ + DG TPL A Q GH V+ L ++ + K A+
Sbjct: 124 LEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHL-----INYGTKGKVRLPAL 177
Query: 245 HFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDR 303
H AA T+ + LL + G TPLH AA L Q+L+ GA ++ +
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237
Query: 304 DGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDS----GMSSPNT 359
+G T ++ G+ R L D A++E K D ++ N
Sbjct: 238 NGITPLHIASRRGNVIMVRLL--------------LDRGAQIETKTKDELTPLHCAARNG 283
Query: 360 TVSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQHPPC 397
V + + D +P + + S H + +G H C
Sbjct: 284 HVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDC 320
Score = 109 bits (273), Expect = 9e-24
Identities = 98/317 (30%), Positives = 148/317 (46%), Gaps = 12/317 (3%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
A +QG +V+ L G G +R P +H AAR L++ P ++
Sbjct: 151 ALQQGHENVVAHLINYGTKG-KVRLPA----LHIAARNDDTRTAAVLLQNDPNPDVL-SK 204
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G TP H A+ +L Q LL++G V +G T LH+A+R G+ +V LL G
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
T D P+H AA G +L++H + A+TKNG +P+++A Q HL+
Sbjct: 264 QIETKTKDE-LTPLHCAARNGHVRISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCV 321
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
+ L+Q A+ D +TPLH AA GH V L+ + + +G T +H A
Sbjct: 322 RLLLQY-DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIAC 379
Query: 249 SRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
+ H +V+ LL G I A G TPLH A+ G L + L+ GA +V + T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 308 AADLSDFNGHSHCTRYL 324
++ GH+ +YL
Sbjct: 440 PLHMAARAGHTEVAKYL 456
Score = 99.0 bits (245), Expect = 2e-20
Identities = 79/300 (26%), Positives = 138/300 (46%), Gaps = 37/300 (12%)
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
+NG H AS GH+ + LL + ++ G T LH+AA G EVV L+++G
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 128 GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEV 187
+ A + G P++ AA + ++ L+E+ N T++G TPL +A Q+GH V
Sbjct: 102 A-NVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GANQNVATEDGFTPLAVALQQGHENV 159
Query: 188 TQYLVQ----------------------------ECGADPHARAHDGMTPLHAAAQMGHS 219
+L+ + +P + G TPLH AA +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 220 PVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLHD 278
V L++ S++ ++G T +H A+ RG+ ++ LL G +I TPLH
Sbjct: 220 NVAQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 278
Query: 279 AAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTR----YLRTVENLSVEH 334
AA NG + +IL+ +GA + + ++G + ++ H C R Y +++++++H
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 133 bits (334), Expect = 8e-31
Identities = 106/352 (30%), Positives = 169/352 (48%), Gaps = 14/352 (3%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AAR G ++++ L P+L P+H AAR G + + L+E+ A A +
Sbjct: 477 AARIGHTNMVKLL-LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA-SQACMTK 534
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G TP H A+ G + + LL + +G T LH+A + ++V LL GG
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+ A + G P+H AA + R L++ Y NA++ G TPL+LA QEGH E+
Sbjct: 594 SPHSPAWN-GYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMV 651
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
L+ + A+ + G+TPLH AQ GH PV L+ V + + G T +H A+
Sbjct: 652 ALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVAS 709
Query: 249 SRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
G+ K++ +LL H +++A G +PLH AA+ G + +L+ NGA + DG T
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 308 AADLSDFNGHSHCTRYLRTVEN------LSVEHRVLSRDPSAELEAKQPDSG 353
++ G+ T L+ V + +S +HR+ + E+ D G
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG 821
Score = 130 bits (327), Expect = 5e-30
Identities = 98/314 (31%), Positives = 156/314 (49%), Gaps = 14/314 (4%)
Query: 9 AARQGELDVLRSL-HAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
AAR G +V + L + +D D P+H AAR G + ++ L+E A P A
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKD--DQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
G TP H A+ GH+ + LL + + G T LH+AA++G V LL
Sbjct: 502 A-GHTPLHIAAREGHVETVLALLEKEASQA-CMTKKGFTPLHVAAKYGKVRVAELLLER- 558
Query: 128 GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTK--NGATPLYLACQEGHL 185
P AA G P+H A + ++LL+ P G + + NG TPL++A ++ +
Sbjct: 559 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL---PRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 186 EVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMH 245
EV + L+Q G +A + G+TPLH AAQ GH+ ++ L+S + + +K G T +H
Sbjct: 616 EVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKSGLTPLH 673
Query: 246 FAASRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRD 304
A GH V L+ HG + A G TPLH A+ G ++ + L+ + A+++ + +
Sbjct: 674 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 733
Query: 305 GYTAADLSDFNGHS 318
GY+ + GH+
Sbjct: 734 GYSPLHQAAQQGHT 747
Score = 122 bits (307), Expect = 1e-27
Identities = 85/280 (30%), Positives = 143/280 (51%), Gaps = 7/280 (2%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H A+R G + +R L++ A + ++ TP H A+ GH+ + LL G +Q
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGA-PIQ 299
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
K +G + +H+AA+ H + V LL + D P+H AA G ++L+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLL 358
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
+ + N++ NG TPL++AC++ H+ V + L++ GA A G+TPLH A+ MGH
Sbjct: 359 DKGAKP-NSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGH 416
Query: 219 SPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLH 277
P++ L+ S + + T +H AA GHT+V +LL + +++A TPLH
Sbjct: 417 LPIVKNLLQ-RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
Query: 278 DAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGH 317
AA G ++L+ N A ++ G+T ++ GH
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 117 bits (292), Expect = 6e-26
Identities = 91/319 (28%), Positives = 141/319 (44%), Gaps = 38/319 (11%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA G + L+++ A P + RA NG TP H A H+ ++ LL + G +
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNS-RALNGFTPLHIACKKNHVRVME-LLLKTGASID 398
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
SG T LH+A+ GH +V LL G P + P+H AA G + L+
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
++ + VNA+ K+ TPL+ A + GH + + L+ E A+P+ G TPLH AA+ GH
Sbjct: 458 QNKAK-VNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGH 515
Query: 219 SPVIVWLV------SC--------------------------TDVSLSEQDKDGATAMHF 246
++ L+ +C D + K+G T +H
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Query: 247 AASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDG 305
A + ++ LL GG + W G TPLH AA+ ++E + L+ G + G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 306 YTAADLSDFNGHSHCTRYL 324
T L+ GH+ L
Sbjct: 636 VTPLHLAAQEGHAEMVALL 654
Score = 112 bits (281), Expect = 1e-24
Identities = 96/319 (30%), Positives = 157/319 (49%), Gaps = 16/319 (5%)
Query: 9 AARQGELD-VLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
A+++G + V+ LH +L + + AL H AA AG+ +R LV A A++
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTAL--HIAALAGQDEVVRELVNYGA-NVNAQS 108
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
+ G TP + A+ HL +++LL + G G T L +A + GH VV L+++G
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 128 GGDPTAATDMGALP-IHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLE 186
LP +H AA D + +L+++ P + +K G TPL++A +L
Sbjct: 168 TKGKVR------LPALHIAARNDDTRTAAVLLQNDPNP-DVLSKTGFTPLHIAAHYENLN 220
Query: 187 VTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHF 246
V Q L+ GA + +G+TPLH A++ G+ ++V L+ + + KD T +H
Sbjct: 221 VAQLLLNR-GASVNFTPQNGITPLHIASRRGNV-IMVRLLLDRGAQIETKTKDELTPLHC 278
Query: 247 AASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDG 305
AA GH ++ LL HG I A G +P+H AA+ L+C ++L+ AE+D D
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 306 YTAADLSDFNGHSHCTRYL 324
T ++ GH + L
Sbjct: 339 LTPLHVAAHCGHHRVAKVL 357
Score = 111 bits (277), Expect = 3e-24
Identities = 101/338 (29%), Positives = 152/338 (44%), Gaps = 31/338 (9%)
Query: 66 RARNGATPAHDASATGHL-ACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLL 124
R + AT A+ +G+L L L + G + + +G LHLA++ GH ++V LL
Sbjct: 8 READAATSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 125 HHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGH 184
H T T G +H AA G +R LV +Y VNAQ++ G TPLY+A QE H
Sbjct: 66 HKEIILETT-TKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENH 123
Query: 185 LEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAM 244
LEV ++L+ E GA+ + DG TPL A Q GH V+ L ++ + K A+
Sbjct: 124 LEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHL-----INYGTKGKVRLPAL 177
Query: 245 HFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDR 303
H AA T+ + LL + G TPLH AA L Q+L+ GA ++ +
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237
Query: 304 DGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDS----GMSSPNT 359
+G T ++ G+ R L D A++E K D ++ N
Sbjct: 238 NGITPLHIASRRGNVIMVRLL--------------LDRGAQIETKTKDELTPLHCAARNG 283
Query: 360 TVSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQHPPC 397
V + + D +P + + S H + +G H C
Sbjct: 284 HVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDC 320
Score = 109 bits (273), Expect = 9e-24
Identities = 98/317 (30%), Positives = 148/317 (46%), Gaps = 12/317 (3%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
A +QG +V+ L G G +R P +H AAR L++ P ++
Sbjct: 151 ALQQGHENVVAHLINYGTKG-KVRLPA----LHIAARNDDTRTAAVLLQNDPNPDVL-SK 204
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G TP H A+ +L Q LL++G V +G T LH+A+R G+ +V LL G
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
T D P+H AA G +L++H + A+TKNG +P+++A Q HL+
Sbjct: 264 QIETKTKDE-LTPLHCAARNGHVRISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCV 321
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
+ L+Q A+ D +TPLH AA GH V L+ + + +G T +H A
Sbjct: 322 RLLLQY-DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIAC 379
Query: 249 SRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
+ H +V+ LL G I A G TPLH A+ G L + L+ GA +V + T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 308 AADLSDFNGHSHCTRYL 324
++ GH+ +YL
Sbjct: 440 PLHMAARAGHTEVAKYL 456
Score = 99.0 bits (245), Expect = 2e-20
Identities = 79/300 (26%), Positives = 138/300 (46%), Gaps = 37/300 (12%)
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
+NG H AS GH+ + LL + ++ G T LH+AA G EVV L+++G
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 128 GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEV 187
+ A + G P++ AA + ++ L+E+ N T++G TPL +A Q+GH V
Sbjct: 102 A-NVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GANQNVATEDGFTPLAVALQQGHENV 159
Query: 188 TQYLVQ----------------------------ECGADPHARAHDGMTPLHAAAQMGHS 219
+L+ + +P + G TPLH AA +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 220 PVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLHD 278
V L++ S++ ++G T +H A+ RG+ ++ LL G +I TPLH
Sbjct: 220 NVAQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 278
Query: 279 AAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTR----YLRTVENLSVEH 334
AA NG + +IL+ +GA + + ++G + ++ H C R Y +++++++H
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 133 bits (334), Expect = 8e-31
Identities = 106/352 (30%), Positives = 169/352 (48%), Gaps = 14/352 (3%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AAR G ++++ L P+L P+H AAR G + + L+E+ A A +
Sbjct: 477 AARIGHTNMVKLL-LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA-SQACMTK 534
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G TP H A+ G + + LL + +G T LH+A + ++V LL GG
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+ A + G P+H AA + R L++ Y NA++ G TPL+LA QEGH E+
Sbjct: 594 SPHSPAWN-GYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMV 651
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
L+ + A+ + G+TPLH AQ GH PV L+ V + + G T +H A+
Sbjct: 652 ALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVAS 709
Query: 249 SRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
G+ K++ +LL H +++A G +PLH AA+ G + +L+ NGA + DG T
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 308 AADLSDFNGHSHCTRYLRTVEN------LSVEHRVLSRDPSAELEAKQPDSG 353
++ G+ T L+ V + +S +HR+ + E+ D G
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG 821
Score = 130 bits (327), Expect = 5e-30
Identities = 98/314 (31%), Positives = 156/314 (49%), Gaps = 14/314 (4%)
Query: 9 AARQGELDVLRSL-HAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
AAR G +V + L + +D D P+H AAR G + ++ L+E A P A
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKD--DQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
G TP H A+ GH+ + LL + + G T LH+AA++G V LL
Sbjct: 502 A-GHTPLHIAAREGHVETVLALLEKEASQA-CMTKKGFTPLHVAAKYGKVRVAELLLER- 558
Query: 128 GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTK--NGATPLYLACQEGHL 185
P AA G P+H A + ++LL+ P G + + NG TPL++A ++ +
Sbjct: 559 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL---PRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 186 EVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMH 245
EV + L+Q G +A + G+TPLH AAQ GH+ ++ L+S + + +K G T +H
Sbjct: 616 EVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKSGLTPLH 673
Query: 246 FAASRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRD 304
A GH V L+ HG + A G TPLH A+ G ++ + L+ + A+++ + +
Sbjct: 674 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 733
Query: 305 GYTAADLSDFNGHS 318
GY+ + GH+
Sbjct: 734 GYSPLHQAAQQGHT 747
Score = 122 bits (307), Expect = 1e-27
Identities = 85/280 (30%), Positives = 143/280 (51%), Gaps = 7/280 (2%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H A+R G + +R L++ A + ++ TP H A+ GH+ + LL G +Q
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGA-PIQ 299
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
K +G + +H+AA+ H + V LL + D P+H AA G ++L+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLL 358
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
+ + N++ NG TPL++AC++ H+ V + L++ GA A G+TPLH A+ MGH
Sbjct: 359 DKGAKP-NSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGH 416
Query: 219 SPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLH 277
P++ L+ S + + T +H AA GHT+V +LL + +++A TPLH
Sbjct: 417 LPIVKNLLQ-RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
Query: 278 DAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGH 317
AA G ++L+ N A ++ G+T ++ GH
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 117 bits (292), Expect = 6e-26
Identities = 91/319 (28%), Positives = 141/319 (44%), Gaps = 38/319 (11%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA G + L+++ A P + RA NG TP H A H+ ++ LL + G +
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNS-RALNGFTPLHIACKKNHVRVME-LLLKTGASID 398
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
SG T LH+A+ GH +V LL G P + P+H AA G + L+
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
++ + VNA+ K+ TPL+ A + GH + + L+ E A+P+ G TPLH AA+ GH
Sbjct: 458 QNKAK-VNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGH 515
Query: 219 SPVIVWLV------SC--------------------------TDVSLSEQDKDGATAMHF 246
++ L+ +C D + K+G T +H
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Query: 247 AASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDG 305
A + ++ LL GG + W G TPLH AA+ ++E + L+ G + G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 306 YTAADLSDFNGHSHCTRYL 324
T L+ GH+ L
Sbjct: 636 VTPLHLAAQEGHAEMVALL 654
Score = 112 bits (281), Expect = 1e-24
Identities = 96/319 (30%), Positives = 157/319 (49%), Gaps = 16/319 (5%)
Query: 9 AARQGELD-VLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
A+++G + V+ LH +L + + AL H AA AG+ +R LV A A++
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTAL--HIAALAGQDEVVRELVNYGA-NVNAQS 108
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
+ G TP + A+ HL +++LL + G G T L +A + GH VV L+++G
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 128 GGDPTAATDMGALP-IHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLE 186
LP +H AA D + +L+++ P + +K G TPL++A +L
Sbjct: 168 TKGKVR------LPALHIAARNDDTRTAAVLLQNDPNP-DVLSKTGFTPLHIAAHYENLN 220
Query: 187 VTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHF 246
V Q L+ GA + +G+TPLH A++ G+ ++V L+ + + KD T +H
Sbjct: 221 VAQLLLNR-GASVNFTPQNGITPLHIASRRGNV-IMVRLLLDRGAQIETKTKDELTPLHC 278
Query: 247 AASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDG 305
AA GH ++ LL HG I A G +P+H AA+ L+C ++L+ AE+D D
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 306 YTAADLSDFNGHSHCTRYL 324
T ++ GH + L
Sbjct: 339 LTPLHVAAHCGHHRVAKVL 357
Score = 111 bits (277), Expect = 3e-24
Identities = 101/338 (29%), Positives = 152/338 (44%), Gaps = 31/338 (9%)
Query: 66 RARNGATPAHDASATGHL-ACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLL 124
R + AT A+ +G+L L L + G + + +G LHLA++ GH ++V LL
Sbjct: 8 READAATSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 125 HHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGH 184
H T T G +H AA G +R LV +Y VNAQ++ G TPLY+A QE H
Sbjct: 66 HKEIILETT-TKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENH 123
Query: 185 LEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAM 244
LEV ++L+ E GA+ + DG TPL A Q GH V+ L ++ + K A+
Sbjct: 124 LEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHL-----INYGTKGKVRLPAL 177
Query: 245 HFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDR 303
H AA T+ + LL + G TPLH AA L Q+L+ GA ++ +
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237
Query: 304 DGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDS----GMSSPNT 359
+G T ++ G+ R L D A++E K D ++ N
Sbjct: 238 NGITPLHIASRRGNVIMVRLL--------------LDRGAQIETKTKDELTPLHCAARNG 283
Query: 360 TVSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQHPPC 397
V + + D +P + + S H + +G H C
Sbjct: 284 HVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDC 320
Score = 109 bits (273), Expect = 9e-24
Identities = 98/317 (30%), Positives = 148/317 (46%), Gaps = 12/317 (3%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
A +QG +V+ L G G +R P +H AAR L++ P ++
Sbjct: 151 ALQQGHENVVAHLINYGTKG-KVRLPA----LHIAARNDDTRTAAVLLQNDPNPDVL-SK 204
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G TP H A+ +L Q LL++G V +G T LH+A+R G+ +V LL G
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
T D P+H AA G +L++H + A+TKNG +P+++A Q HL+
Sbjct: 264 QIETKTKDE-LTPLHCAARNGHVRISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCV 321
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
+ L+Q A+ D +TPLH AA GH V L+ + + +G T +H A
Sbjct: 322 RLLLQY-DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIAC 379
Query: 249 SRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
+ H +V+ LL G I A G TPLH A+ G L + L+ GA +V + T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 308 AADLSDFNGHSHCTRYL 324
++ GH+ +YL
Sbjct: 440 PLHMAARAGHTEVAKYL 456
Score = 99.0 bits (245), Expect = 2e-20
Identities = 79/300 (26%), Positives = 138/300 (46%), Gaps = 37/300 (12%)
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
+NG H AS GH+ + LL + ++ G T LH+AA G EVV L+++G
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 128 GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEV 187
+ A + G P++ AA + ++ L+E+ N T++G TPL +A Q+GH V
Sbjct: 102 A-NVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GANQNVATEDGFTPLAVALQQGHENV 159
Query: 188 TQYLVQ----------------------------ECGADPHARAHDGMTPLHAAAQMGHS 219
+L+ + +P + G TPLH AA +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 220 PVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLHD 278
V L++ S++ ++G T +H A+ RG+ ++ LL G +I TPLH
Sbjct: 220 NVAQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 278
Query: 279 AAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTR----YLRTVENLSVEH 334
AA NG + +IL+ +GA + + ++G + ++ H C R Y +++++++H
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 132 bits (331), Expect = 2e-30
Identities = 97/317 (30%), Positives = 153/317 (48%), Gaps = 8/317 (2%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AAR G+++V+R L G L + R + P+H A+R GK ++ L++ A P AA
Sbjct: 450 AARAGQVEVVRCLLRNGALVDA-RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT- 507
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
NG TP H ++ G + LL G G T LH+AA++G +V LL
Sbjct: 508 NGYTPLHISAREGQVDVASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLLLQRRA 566
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+A + G P+H AA D + LL+ +A KNG TPL++A ++ +++
Sbjct: 567 AADSAGKN-GLTPLH-VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 624
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
L+ GA+ + G+TPLH A+Q GH+ ++ L+ ++ K G T++H AA
Sbjct: 625 STLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-KGANIHMSTKSGLTSLHLAA 682
Query: 249 SRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
V L HG + A G TPL A G ++ L+ GA ++ + ++GYT
Sbjct: 683 QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 742
Query: 308 AADLSDFNGHSHCTRYL 324
+ GH+H L
Sbjct: 743 PLHQAAQQGHTHIINVL 759
Score = 130 bits (327), Expect = 5e-30
Identities = 98/287 (34%), Positives = 144/287 (50%), Gaps = 7/287 (2%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA G ++ L+ A ARNG TP H AS G+ ++ LL +GG ++
Sbjct: 215 PLHIAAHYGNVNVATLLLNRGAA-VDFTARNGITPLHVASKRGNTNMVKLLLDRGG-QID 272
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
K G T LH AAR GH +VV LL G A T G P+H AA ++ L+
Sbjct: 273 AKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKNGLSPLHMAAQGDHVECVKHLL 331
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
+H V+ T + T L++A GH VT+ L+ + A+P+ARA +G TPLH A +
Sbjct: 332 QHKAP-VDDVTLDYLTALHVAAHCGHYRVTKLLLDK-RANPNARALNGFTPLHIACKKNR 389
Query: 219 SPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLH 277
V+ LV S+ + G T +H AA GH ++ LL +G ++ G T LH
Sbjct: 390 IKVMELLVKY-GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 448
Query: 278 DAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
AA G++E + L+ NGA +D R R+ T ++ G + + L
Sbjct: 449 MAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495
Score = 125 bits (314), Expect = 2e-28
Identities = 102/319 (31%), Positives = 147/319 (46%), Gaps = 21/319 (6%)
Query: 15 LDVLRSLHAAGLLG--------------PSLRDPLDALPVHHAARAGKLHCLRFLVEEAA 60
LD L +LH A G P+ R P+H A + ++ + LV+ A
Sbjct: 342 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 401
Query: 61 LPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVV 120
A +G TP H A+ GHL + LL Q G + G T LH+AAR G EVV
Sbjct: 402 -SIQAITESGLTPIHVAAFMGHLNIVLLLL-QNGASPDVTNIRGETALHMAARAGQVEVV 459
Query: 121 NWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLAC 180
LL +G A + P+H A+ G ++LL++H +A T NG TPL+++
Sbjct: 460 RCLLRNGALVDARAREEQT-PLHIASRLGKTEIVQLLLQHMAHP-DAATTNGYTPLHISA 517
Query: 181 QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDG 240
+EG ++V L+ E GA G TPLH AA+ G V L+ + K+G
Sbjct: 518 REGQVDVASVLL-EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ-RRAAADSAGKNG 575
Query: 241 ATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELD 299
T +H AA + KV LL G A G TPLH AA+ +++ L+ GAE +
Sbjct: 576 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 635
Query: 300 VRDRDGYTAADLSDFNGHS 318
+ + G T L+ GH+
Sbjct: 636 IVTKQGVTPLHLASQEGHT 654
Score = 116 bits (291), Expect = 8e-26
Identities = 80/245 (32%), Positives = 123/245 (50%), Gaps = 23/245 (9%)
Query: 92 QGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDF 151
+GG + + +G LHLAA+ GH +V LL G +AT G +H A+ G
Sbjct: 31 KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS-VDSATKKGNTALHIASLAGQA 89
Query: 152 PSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLH 211
+++LV+ +NAQ++NG TPLY+A QE H++V +YL+ E GA+ DG TPL
Sbjct: 90 EVVKVLVKE-GANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGANQSTATEDGFTPLA 147
Query: 212 AAAQMGHSPVIVWLVSCTDVSLSEQDKDGAT---AMHFAASRGHTKVLSWLLL--HGGEI 266
A Q GH+ + L+ E D G A+H AA + TK + LL H ++
Sbjct: 148 VALQQGHNQAVAILL--------ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV 199
Query: 267 SADLW-------GGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSH 319
+ + G TPLH AA G + +L+ GA +D R+G T ++ G+++
Sbjct: 200 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 259
Query: 320 CTRYL 324
+ L
Sbjct: 260 MVKLL 264
Score = 112 bits (281), Expect = 1e-24
Identities = 83/265 (31%), Positives = 134/265 (50%), Gaps = 7/265 (2%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
+AR+G++DV L AG SL P+H AA+ G L + L++ A +A +
Sbjct: 516 SAREGQVDVASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSA-GK 573
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
NG TP H A+ + LL +G N G T LH+AA+ ++ + LL++G
Sbjct: 574 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN-GYTPLHIAAKKNQMQIASTLLNYGA 632
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+ T G P+H A+ +G + LL++ ++ TK+G T L+LA QE + V
Sbjct: 633 -ETNIVTKQGVTPLHLASQEGHTDMVTLLLDK-GANIHMSTKSGLTSLHLAAQEDKVNVA 690
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
L + GAD A G TPL A G+ ++ +L+ +++ + K+G T +H AA
Sbjct: 691 DILTKH-GADQDAHTKLGYTPLIVACHYGNVKMVNFLLK-QGANVNAKTKNGYTPLHQAA 748
Query: 249 SRGHTKVLSWLLLHGGEISADLWGG 273
+GHT +++ LL HG + +A G
Sbjct: 749 QQGHTHIINVLLQHGAKPNATTANG 773
Score = 90.5 bits (223), Expect = 6e-18
Identities = 68/206 (33%), Positives = 101/206 (49%), Gaps = 11/206 (5%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA+ ++ L+ A + G TP H AS GH + LL +G +
Sbjct: 611 PLHIAAKKNQMQIASTLLNYGAETNIV-TKQGVTPLHLASQEGHTDMVTLLLDKGA-NIH 668
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
SG T LHLAA+ V + L HG D A T +G P+ A G+ + L+
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADILTKHGA-DQDAHTKLGYTPLIVACHYGNVKMVNFLL 727
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
+ VNA+TKNG TPL+ A Q+GH + L+Q GA P+A +G T L A ++G+
Sbjct: 728 KQ-GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH-GAKPNATTANGNTALAIAKRLGY 785
Query: 219 SPVIVWL------VSCTDVSLSEQDK 238
V+ L V+ T +++E+ K
Sbjct: 786 ISVVDTLKVVTEEVTTTTTTITEKHK 811
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 132 bits (331), Expect = 2e-30
Identities = 97/317 (30%), Positives = 153/317 (48%), Gaps = 8/317 (2%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AAR G+++V+R L G L + R + P+H A+R GK ++ L++ A P AA
Sbjct: 471 AARAGQVEVVRCLLRNGALVDA-RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT- 528
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
NG TP H ++ G + LL G G T LH+AA++G +V LL
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+A + G P+H AA D + LL+ +A KNG TPL++A ++ +++
Sbjct: 588 AADSAGKN-GLTPLH-VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 645
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
L+ GA+ + G+TPLH A+Q GH+ ++ L+ ++ K G T++H AA
Sbjct: 646 STLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-KGANIHMSTKSGLTSLHLAA 703
Query: 249 SRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
V L HG + A G TPL A G ++ L+ GA ++ + ++GYT
Sbjct: 704 QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 763
Query: 308 AADLSDFNGHSHCTRYL 324
+ GH+H L
Sbjct: 764 PLHQAAQQGHTHIINVL 780
Score = 130 bits (327), Expect = 5e-30
Identities = 98/287 (34%), Positives = 144/287 (50%), Gaps = 7/287 (2%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA G ++ L+ A ARNG TP H AS G+ ++ LL +GG ++
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAA-VDFTARNGITPLHVASKRGNTNMVKLLLDRGG-QID 293
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
K G T LH AAR GH +VV LL G A T G P+H AA ++ L+
Sbjct: 294 AKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKNGLSPLHMAAQGDHVECVKHLL 352
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
+H V+ T + T L++A GH VT+ L+ + A+P+ARA +G TPLH A +
Sbjct: 353 QHKAP-VDDVTLDYLTALHVAAHCGHYRVTKLLLDK-RANPNARALNGFTPLHIACKKNR 410
Query: 219 SPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLH 277
V+ LV S+ + G T +H AA GH ++ LL +G ++ G T LH
Sbjct: 411 IKVMELLVKY-GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 469
Query: 278 DAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
AA G++E + L+ NGA +D R R+ T ++ G + + L
Sbjct: 470 MAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Score = 125 bits (314), Expect = 2e-28
Identities = 102/319 (31%), Positives = 147/319 (46%), Gaps = 21/319 (6%)
Query: 15 LDVLRSLHAAGLLG--------------PSLRDPLDALPVHHAARAGKLHCLRFLVEEAA 60
LD L +LH A G P+ R P+H A + ++ + LV+ A
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 422
Query: 61 LPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVV 120
A +G TP H A+ GHL + LL Q G + G T LH+AAR G EVV
Sbjct: 423 -SIQAITESGLTPIHVAAFMGHLNIVLLLL-QNGASPDVTNIRGETALHMAARAGQVEVV 480
Query: 121 NWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLAC 180
LL +G A + P+H A+ G ++LL++H +A T NG TPL+++
Sbjct: 481 RCLLRNGALVDARAREEQT-PLHIASRLGKTEIVQLLLQHMAHP-DAATTNGYTPLHISA 538
Query: 181 QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDG 240
+EG ++V L+ E GA G TPLH AA+ G V L+ + K+G
Sbjct: 539 REGQVDVASVLL-EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ-RRAAADSAGKNG 596
Query: 241 ATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELD 299
T +H AA + KV LL G A G TPLH AA+ +++ L+ GAE +
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656
Query: 300 VRDRDGYTAADLSDFNGHS 318
+ + G T L+ GH+
Sbjct: 657 IVTKQGVTPLHLASQEGHT 675
Score = 116 bits (291), Expect = 8e-26
Identities = 80/245 (32%), Positives = 123/245 (50%), Gaps = 23/245 (9%)
Query: 92 QGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDF 151
+GG + + +G LHLAA+ GH +V LL G +AT G +H A+ G
Sbjct: 52 KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS-VDSATKKGNTALHIASLAGQA 110
Query: 152 PSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLH 211
+++LV+ +NAQ++NG TPLY+A QE H++V +YL+ E GA+ DG TPL
Sbjct: 111 EVVKVLVKE-GANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGANQSTATEDGFTPLA 168
Query: 212 AAAQMGHSPVIVWLVSCTDVSLSEQDKDGAT---AMHFAASRGHTKVLSWLLL--HGGEI 266
A Q GH+ + L+ E D G A+H AA + TK + LL H ++
Sbjct: 169 VALQQGHNQAVAILL--------ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV 220
Query: 267 SADLW-------GGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSH 319
+ + G TPLH AA G + +L+ GA +D R+G T ++ G+++
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280
Query: 320 CTRYL 324
+ L
Sbjct: 281 MVKLL 285
Score = 112 bits (281), Expect = 1e-24
Identities = 83/265 (31%), Positives = 134/265 (50%), Gaps = 7/265 (2%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
+AR+G++DV L AG SL P+H AA+ G L + L++ A +A +
Sbjct: 537 SAREGQVDVASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSA-GK 594
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
NG TP H A+ + LL +G N G T LH+AA+ ++ + LL++G
Sbjct: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN-GYTPLHIAAKKNQMQIASTLLNYGA 653
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+ T G P+H A+ +G + LL++ ++ TK+G T L+LA QE + V
Sbjct: 654 -ETNIVTKQGVTPLHLASQEGHTDMVTLLLDK-GANIHMSTKSGLTSLHLAAQEDKVNVA 711
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
L + GAD A G TPL A G+ ++ +L+ +++ + K+G T +H AA
Sbjct: 712 DILTKH-GADQDAHTKLGYTPLIVACHYGNVKMVNFLLK-QGANVNAKTKNGYTPLHQAA 769
Query: 249 SRGHTKVLSWLLLHGGEISADLWGG 273
+GHT +++ LL HG + +A G
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTANG 794
Score = 90.5 bits (223), Expect = 6e-18
Identities = 68/206 (33%), Positives = 101/206 (49%), Gaps = 11/206 (5%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA+ ++ L+ A + G TP H AS GH + LL +G +
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETNIV-TKQGVTPLHLASQEGHTDMVTLLLDKGA-NIH 689
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
SG T LHLAA+ V + L HG D A T +G P+ A G+ + L+
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGA-DQDAHTKLGYTPLIVACHYGNVKMVNFLL 748
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
+ VNA+TKNG TPL+ A Q+GH + L+Q GA P+A +G T L A ++G+
Sbjct: 749 KQ-GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH-GAKPNATTANGNTALAIAKRLGY 806
Query: 219 SPVIVWL------VSCTDVSLSEQDK 238
V+ L V+ T +++E+ K
Sbjct: 807 ISVVDTLKVVTEEVTTTTTTITEKHK 832
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 132 bits (331), Expect = 2e-30
Identities = 97/317 (30%), Positives = 153/317 (48%), Gaps = 8/317 (2%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AAR G+++V+R L G L + R + P+H A+R GK ++ L++ A P AA
Sbjct: 471 AARAGQVEVVRCLLRNGALVDA-RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT- 528
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
NG TP H ++ G + LL G G T LH+AA++G +V LL
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+A + G P+H AA D + LL+ +A KNG TPL++A ++ +++
Sbjct: 588 AADSAGKN-GLTPLH-VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 645
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
L+ GA+ + G+TPLH A+Q GH+ ++ L+ ++ K G T++H AA
Sbjct: 646 STLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-KGANIHMSTKSGLTSLHLAA 703
Query: 249 SRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
V L HG + A G TPL A G ++ L+ GA ++ + ++GYT
Sbjct: 704 QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 763
Query: 308 AADLSDFNGHSHCTRYL 324
+ GH+H L
Sbjct: 764 PLHQAAQQGHTHIINVL 780
Score = 130 bits (327), Expect = 5e-30
Identities = 98/287 (34%), Positives = 144/287 (50%), Gaps = 7/287 (2%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA G ++ L+ A ARNG TP H AS G+ ++ LL +GG ++
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAA-VDFTARNGITPLHVASKRGNTNMVKLLLDRGG-QID 293
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
K G T LH AAR GH +VV LL G A T G P+H AA ++ L+
Sbjct: 294 AKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKNGLSPLHMAAQGDHVECVKHLL 352
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
+H V+ T + T L++A GH VT+ L+ + A+P+ARA +G TPLH A +
Sbjct: 353 QHKAP-VDDVTLDYLTALHVAAHCGHYRVTKLLLDK-RANPNARALNGFTPLHIACKKNR 410
Query: 219 SPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLH 277
V+ LV S+ + G T +H AA GH ++ LL +G ++ G T LH
Sbjct: 411 IKVMELLVKY-GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 469
Query: 278 DAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
AA G++E + L+ NGA +D R R+ T ++ G + + L
Sbjct: 470 MAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Score = 125 bits (314), Expect = 2e-28
Identities = 102/319 (31%), Positives = 147/319 (46%), Gaps = 21/319 (6%)
Query: 15 LDVLRSLHAAGLLG--------------PSLRDPLDALPVHHAARAGKLHCLRFLVEEAA 60
LD L +LH A G P+ R P+H A + ++ + LV+ A
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 422
Query: 61 LPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVV 120
A +G TP H A+ GHL + LL Q G + G T LH+AAR G EVV
Sbjct: 423 -SIQAITESGLTPIHVAAFMGHLNIVLLLL-QNGASPDVTNIRGETALHMAARAGQVEVV 480
Query: 121 NWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLAC 180
LL +G A + P+H A+ G ++LL++H +A T NG TPL+++
Sbjct: 481 RCLLRNGALVDARAREEQT-PLHIASRLGKTEIVQLLLQHMAHP-DAATTNGYTPLHISA 538
Query: 181 QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDG 240
+EG ++V L+ E GA G TPLH AA+ G V L+ + K+G
Sbjct: 539 REGQVDVASVLL-EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ-RRAAADSAGKNG 596
Query: 241 ATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELD 299
T +H AA + KV LL G A G TPLH AA+ +++ L+ GAE +
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656
Query: 300 VRDRDGYTAADLSDFNGHS 318
+ + G T L+ GH+
Sbjct: 657 IVTKQGVTPLHLASQEGHT 675
Score = 116 bits (291), Expect = 8e-26
Identities = 80/245 (32%), Positives = 123/245 (50%), Gaps = 23/245 (9%)
Query: 92 QGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDF 151
+GG + + +G LHLAA+ GH +V LL G +AT G +H A+ G
Sbjct: 52 KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS-VDSATKKGNTALHIASLAGQA 110
Query: 152 PSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLH 211
+++LV+ +NAQ++NG TPLY+A QE H++V +YL+ E GA+ DG TPL
Sbjct: 111 EVVKVLVKE-GANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGANQSTATEDGFTPLA 168
Query: 212 AAAQMGHSPVIVWLVSCTDVSLSEQDKDGAT---AMHFAASRGHTKVLSWLLL--HGGEI 266
A Q GH+ + L+ E D G A+H AA + TK + LL H ++
Sbjct: 169 VALQQGHNQAVAILL--------ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV 220
Query: 267 SADLW-------GGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSH 319
+ + G TPLH AA G + +L+ GA +D R+G T ++ G+++
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280
Query: 320 CTRYL 324
+ L
Sbjct: 281 MVKLL 285
Score = 112 bits (281), Expect = 1e-24
Identities = 83/265 (31%), Positives = 134/265 (50%), Gaps = 7/265 (2%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
+AR+G++DV L AG SL P+H AA+ G L + L++ A +A +
Sbjct: 537 SAREGQVDVASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSA-GK 594
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
NG TP H A+ + LL +G N G T LH+AA+ ++ + LL++G
Sbjct: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN-GYTPLHIAAKKNQMQIASTLLNYGA 653
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+ T G P+H A+ +G + LL++ ++ TK+G T L+LA QE + V
Sbjct: 654 -ETNIVTKQGVTPLHLASQEGHTDMVTLLLDK-GANIHMSTKSGLTSLHLAAQEDKVNVA 711
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
L + GAD A G TPL A G+ ++ +L+ +++ + K+G T +H AA
Sbjct: 712 DILTKH-GADQDAHTKLGYTPLIVACHYGNVKMVNFLLK-QGANVNAKTKNGYTPLHQAA 769
Query: 249 SRGHTKVLSWLLLHGGEISADLWGG 273
+GHT +++ LL HG + +A G
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTANG 794
Score = 90.5 bits (223), Expect = 6e-18
Identities = 68/206 (33%), Positives = 101/206 (49%), Gaps = 11/206 (5%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA+ ++ L+ A + G TP H AS GH + LL +G +
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETNIV-TKQGVTPLHLASQEGHTDMVTLLLDKGA-NIH 689
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
SG T LHLAA+ V + L HG D A T +G P+ A G+ + L+
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGA-DQDAHTKLGYTPLIVACHYGNVKMVNFLL 748
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
+ VNA+TKNG TPL+ A Q+GH + L+Q GA P+A +G T L A ++G+
Sbjct: 749 KQ-GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH-GAKPNATTANGNTALAIAKRLGY 806
Query: 219 SPVIVWL------VSCTDVSLSEQDK 238
V+ L V+ T +++E+ K
Sbjct: 807 ISVVDTLKVVTEEVTTTTTTITEKHK 832
Score = 35.0 bits (79), Expect = 0.30
Identities = 80/423 (18%), Positives = 145/423 (34%), Gaps = 65/423 (15%)
Query: 459 KPPVG---PQAADIYMQTKNKLRHVETEALKKELSSCDGHDGLRRQDSSRKPRAFSKQPS 515
KP +G P + + K K ++ A K EL + L +D P +
Sbjct: 1695 KPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLG-EDPGLAPEPLPTVKA 1753
Query: 516 TGDYYRQ--LGRCPGETLAARPGMAHSEEVRARQPARAGCPRLGPAARGSLEGPSAPPQA 573
T + +G + A + + ++ R++ P R P P+A P
Sbjct: 1754 TSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVKGKEDVPKKTTHRPHPAASP-- 1811
Query: 574 ALLPGNHVPNGCAADPKASRE------LPPPPPPPPPPLPEAASSPPPAPPLPLESAGPG 627
+L H P + PK R PP P + P +P E P
Sbjct: 1812 SLKSERHAPG--SPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPA 1869
Query: 628 CG----------------QRRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQS 671
+R S S+ T+ +SP+G + +G++ K P S
Sbjct: 1870 SSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTEKHPPVS 1929
Query: 672 KGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSLVPVPPTTPAPG 731
G T + P+ + D P + + P P+ + PV PT+
Sbjct: 1930 PGRTEKRLPVS-PSGRTDKHQPVSTAGKTEKHLPVSPSGKTE-----KQPPVSPTSKTER 1983
Query: 732 VQ--LDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEEEEARLASMPAW 789
++ + V L+ P K + + E + ++K+ +E+ ++
Sbjct: 1984 IEETMSVRELMKAFQSGQDP----------SKHKTGLFEHKSAKQKQPQEKGKV------ 2027
Query: 790 RRDLLRKKLEEEREQKRKEEERQKQEELRREKEQSEKLRTLGYDESKLAPWQRQVILKKG 849
++E+E+ + E QK E + ++ ++L G ESK + +KK
Sbjct: 2028 -------RVEKEKGPILTQREAQKTEN--QTIKRGQRLPVTGTAESKRGVRVSSIGVKKE 2078
Query: 850 DIA 852
D A
Sbjct: 2079 DAA 2081
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 123 bits (309), Expect = 6e-28
Identities = 96/276 (34%), Positives = 131/276 (47%), Gaps = 14/276 (5%)
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
+GA+ H A G C +WLL + G+T LH+A VV LL
Sbjct: 437 SGASLLHLAVEAGQEECAKWLL-LNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKI 495
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
D +H+AA GD S RLL+E VN G TP+++ACQ G +
Sbjct: 496 SVNAKDEDQWT-ALHFAAQNGDESSTRLLLEK-NASVNEVDFEGRTPMHVACQHGQENIV 553
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
+ L++ G D + D PLH AA GH P++ L VS++ Q DG T +H AA
Sbjct: 554 RILLRR-GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAA 612
Query: 249 SRGHTKVLSWLLLHGGEIS-ADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
RGH +V L+ +++ L TPLH AAE G ++L+ GA + DGYT
Sbjct: 613 QRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYT 672
Query: 308 AADLSDFNGHSHCTRYLRTVENLSVEHR--VLSRDP 341
A L+ NGH L TV+ L VE + VL+R P
Sbjct: 673 ALHLAARNGH------LATVK-LLVEEKADVLARGP 701
Score = 112 bits (281), Expect = 1e-24
Identities = 80/229 (34%), Positives = 115/229 (50%), Gaps = 6/229 (2%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H A + G+ + +R L+ + + + ++ P H A+ GHL ++ L Q G V
Sbjct: 540 PMHVACQHGQENIVRILLRRG-VDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVN 598
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
+ G T LHLAA+ GH V L+ D + + P+H AA G + RLL+
Sbjct: 599 AQTLDGRTPLHLAAQRGHYRVARILIDLCS-DVNVCSLLAQTPLHVAAETGHTSTARLLL 657
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
H G A T +G T L+LA + GHL + LV+E AD AR T LH AA GH
Sbjct: 658 -HRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE-KADVLARGPLNQTALHLAAAHGH 715
Query: 219 SPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEIS 267
S V+ LVS + L D+ G +A+H AA H + + LL HG I+
Sbjct: 716 SEVVEELVSADVIDLF--DEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 112 bits (280), Expect = 1e-24
Identities = 99/324 (30%), Positives = 142/324 (43%), Gaps = 44/324 (13%)
Query: 40 VHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDA---SATGHLACL---------- 86
+H A AG+ C ++L+ A P + R G+TP H A G + L
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSN-RRGSTPLHMAVERRVRGVVELLLARKISVNAK 500
Query: 87 ---QW----------------LLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
QW LL + V + D G T +H+A + G +V LL G
Sbjct: 501 DEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRG 560
Query: 128 GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEV 187
D LP+HYAA +G P ++LL + VNAQT +G TPL+LA Q GH V
Sbjct: 561 VDVSLQGKDAW-LPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619
Query: 188 TQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFA 247
+ L+ C +D + + TPLH AA+ GH+ L+ DG TA+H A
Sbjct: 620 ARILIDLC-SDVNVCSLLAQTPLHVAAETGHTSTARLLLH-RGAGKEAMTSDGYTALHLA 677
Query: 248 ASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGY 306
A GH + L+ ++ A T LH AA +G E + L V+ +D+ D G
Sbjct: 678 ARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL-VSADVIDLFDEQGL 736
Query: 307 TAADLSDFNGHSHCTRYLRTVENL 330
+A L+ H+ +TVE L
Sbjct: 737 SALHLAAQGRHA------QTVETL 754
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 122 bits (307), Expect = 1e-27
Identities = 101/315 (32%), Positives = 144/315 (45%), Gaps = 38/315 (12%)
Query: 37 ALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCR 96
A + A R G + ++ LV + + A +TP H A+ G +++LL Q G
Sbjct: 25 ARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLL-QNGAN 83
Query: 97 VQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRL 156
VQ +D+ G LH A FGH EVVN LL H G DP A + P+H AA KG +
Sbjct: 84 VQARDDGGLIPLHNACSFGHAEVVNLLLRH-GADPNARDNWNYTPLHEAAIKGKIDVCIV 142
Query: 157 LVEHYPEGVNAQTKNGATPLYLA--------------------CQEGHLEVTQYLVQECG 196
L++H E T +G T L LA + G+ E L+
Sbjct: 143 LLQHGAEPTIRNT-DGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201
Query: 197 ADPHARAHDGMTPLHAAAQMGHSPV-IVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKV 255
+ HA TPLH AA G++ V IV L+ + +DK +H A S GH +V
Sbjct: 202 VNCHASDGRKSTPLHLAA--GYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEV 259
Query: 256 LSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLS-- 312
L+ HG ++A DLW TPLH+AA +E C +L+ GA+ + + +A DL+
Sbjct: 260 TELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPT 319
Query: 313 ---------DFNGHS 318
+F GHS
Sbjct: 320 PQLKERLAYEFKGHS 334
Score = 120 bits (301), Expect = 5e-27
Identities = 119/424 (28%), Positives = 195/424 (45%), Gaps = 48/424 (11%)
Query: 5 QALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAA 64
Q A + G +V + L LG S D + AA+AG + ++ L ++
Sbjct: 465 QGFTALQMGNENVQQLLQEGISLGNSEADR----QLLEAAKAGDVETVKKLCTVQSVNCR 520
Query: 65 ARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLL 124
+TP H A+ ++ +++LL Q G V KD G LH A +GH EV L+
Sbjct: 521 DIEGRQSTPLHFAAGYNRVSVVEYLL-QHGADVHAKDKGGLVPLHNACSYGHYEVAELLV 579
Query: 125 HHGGGDPTAATDMGAL----PIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLAC 180
HG A ++ L P+H AAAKG + +LL++H + + ++G TPL L
Sbjct: 580 KHG-----AVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTK-KNRDGNTPLDLV- 632
Query: 181 QEGHLEVTQYL-----------------VQECGADPHARAHDGM----TPLHAAAQMGHS 219
++G ++ L V++ + + D TPLH AA +
Sbjct: 633 KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNL 692
Query: 220 PVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHD 278
V +L+ ++ QDK G +H AAS GH V + L+ + ++A D W TPLH+
Sbjct: 693 EVAEYLLQ-HGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHE 751
Query: 279 AAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENL--SVEHRV 336
AA+ G + C +L+ +GA+ +++++G T DL + S L + +V
Sbjct: 752 AAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQV 811
Query: 337 LS--RDPSAELEAKQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSSH--SSIKG 392
L+ R P A +A SG SSP++ + L+ +LS S LS+ S S + SS++
Sbjct: 812 LNGVRSPGATADAL--SSGPSSPSSLSAASSLD-NLSGSFSELSSVVSSSGTEGASSLEK 868
Query: 393 QHPP 396
+ P
Sbjct: 869 KEVP 872
Score = 97.1 bits (240), Expect = 6e-20
Identities = 90/309 (29%), Positives = 136/309 (44%), Gaps = 17/309 (5%)
Query: 7 LQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAA-- 64
LQAAR E DV R L + + P H A A + + E A
Sbjct: 336 LQAAR--EADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANI 393
Query: 65 -ARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWL 123
+ + TP H AS H ++ ++ +V DN G T LH AA GH + L
Sbjct: 394 NEKTKEFLTPLHVASEKAHNDVVEVVVKHEA-KVNALDNLGQTSLHRAAYCGHLQTCRLL 452
Query: 124 LHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEG 183
L +G DP + G + A + +++ L++ EG++ L A + G
Sbjct: 453 LSYGC-DPNIISLQG-----FTALQMGNENVQQLLQ---EGISLGNSEADRQLLEAAKAG 503
Query: 184 HLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATA 243
+E + L + TPLH AA V+ +L+ + +DK G
Sbjct: 504 DVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQ-HGADVHAKDKGGLVP 562
Query: 244 MHFAASRGHTKVLSWLLLHGGEIS-ADLWGGTPLHDAAENGELECCQILVVNGAELDVRD 302
+H A S GH +V L+ HG ++ ADLW TPLH+AA G+ E C++L+ +GA+ ++
Sbjct: 563 LHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKN 622
Query: 303 RDGYTAADL 311
RDG T DL
Sbjct: 623 RDGNTPLDL 631
Score = 82.4 bits (202), Expect = 2e-15
Identities = 82/315 (26%), Positives = 144/315 (45%), Gaps = 20/315 (6%)
Query: 4 EQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPA 63
++ L++AR G + + +L + D + P+H AA ++ ++ L++ A
Sbjct: 179 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGA-DV 237
Query: 64 AARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWL 123
A+ + P H+A + GH + L+ G C V D T LH AA EV + L
Sbjct: 238 HAKDKGDLVPLHNACSYGHYEVTELLVKHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLL 296
Query: 124 LHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEG 183
L +G DPT L H +A P+ +L E + + K G + L A +
Sbjct: 297 LSYGA-DPTL------LNCHNKSAIDLAPTPQL-----KERLAYEFK-GHSLLQAAREAD 343
Query: 184 HLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSP--VIVWLVSCTDVSLSEQDKDGA 241
+ ++L E H + H+ T LH AA + I L+ +++E+ K+
Sbjct: 344 VTRIKKHLSLEMVNFKHPQTHE--TALHCAAASPYPKRKQICELLLRKGANINEKTKEFL 401
Query: 242 TAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDV 300
T +H A+ + H V+ ++ H +++A D G T LH AA G L+ C++L+ G + ++
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 301 RDRDGYTAADLSDFN 315
G+TA + + N
Sbjct: 462 ISLQGFTALQMGNEN 476
Score = 75.5 bits (184), Expect = 2e-13
Identities = 75/266 (28%), Positives = 117/266 (43%), Gaps = 17/266 (6%)
Query: 60 ALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEV 119
A AA A +A G + ++ L++ +D +T LH AA FG +V
Sbjct: 14 ASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDV 73
Query: 120 VNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLA 179
V +LL +G + A D G +P+H A + G + LL+ H + NA+ TPL+ A
Sbjct: 74 VEYLLQNGA-NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADP-NARDNWNYTPLHEA 131
Query: 180 CQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKD 239
+G ++V L+Q GA+P R DG T L A S V E KD
Sbjct: 132 AIKGKIDVCIVLLQH-GAEPTIRNTDGRTALDLADP-----------SAKAVLTGEYKKD 179
Query: 240 GATAMHFAASRGHTKVLSWLL-LHGGEISADLWGGTPLHDAAENGELECCQILVVNGAEL 298
+ A S K+++ L L+ ++D TPLH AA ++ Q+L+ +GA++
Sbjct: 180 --ELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV 237
Query: 299 DVRDRDGYTAADLSDFNGHSHCTRYL 324
+D+ + GH T L
Sbjct: 238 HAKDKGDLVPLHNACSYGHYEVTELL 263
Score = 70.9 bits (172), Expect = 5e-12
Identities = 87/340 (25%), Positives = 136/340 (40%), Gaps = 48/340 (14%)
Query: 29 PSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPA-----AARARNGATPAHDASATGHL 83
P+ RD + P+H AA GK+ L++ A P A + A P+ A TG
Sbjct: 117 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEY 176
Query: 84 --------------ACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGG 129
+ LL+ D +T LHLAA + ++V LL HG
Sbjct: 177 KKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGA- 235
Query: 130 DPTAATDMGAL-PIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
A D G L P+H A + G + LLV+H VNA TPL+ A + +EV
Sbjct: 236 -DVHAKDKGDLVPLHNACSYGHYEVTELLVKH-GACVNAMDLWQFTPLHEAASKNRVEVC 293
Query: 189 QYLVQECGADP-----HARAHDGMTPL-------------HAAAQMGHSPVIVWLVSCTD 230
L+ GADP H ++ + P H+ Q + +
Sbjct: 294 SLLL-SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLS 352
Query: 231 VSL--SEQDKDGATAMHFAASRGHTK---VLSWLLLHGGEISADLWGG-TPLHDAAENGE 284
+ + + + TA+H AA+ + K + LL G I+ TPLH A+E
Sbjct: 353 LEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAH 412
Query: 285 LECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
+ +++V + A+++ D G T+ + + GH R L
Sbjct: 413 NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
Score = 31.2 bits (69), Expect = 4.3
Identities = 23/70 (32%), Positives = 31/70 (44%), Gaps = 10/70 (14%)
Query: 274 TPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVE 333
TPLH AA G + + L+ NGA + RD G H+ C+ V NL +
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPL-------HNACSFGHAEVVNLLLR 112
Query: 334 HRVLSRDPSA 343
H DP+A
Sbjct: 113 H---GADPNA 119
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 122 bits (306), Expect = 1e-27
Identities = 88/250 (35%), Positives = 125/250 (50%), Gaps = 6/250 (2%)
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
N TP H A G + ++ LL+ V + SG T L +AA+ P++ LL HG
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHE-VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
D + G P+H+AA GD + RLL++H V+AQ + G TPL+LA Q V
Sbjct: 420 -DANRVDEDGWAPLHFAAQNGDDGTARLLLDH-GACVDAQEREGWTPLHLAAQNNFENVA 477
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
+ LV ADP+ +G TPLH AA GH ++ L S L Q ++ T +H A
Sbjct: 478 RLLVSR-QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTS-QGAELDAQQRNLRTPLHLAV 535
Query: 249 SRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
RG + + LL G A D G PLH AA G+ C++L+ GA L++ G+T
Sbjct: 536 ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWT 595
Query: 308 AADLSDFNGH 317
L+ + GH
Sbjct: 596 PLHLAAYKGH 605
Score = 117 bits (292), Expect = 6e-26
Identities = 95/276 (34%), Positives = 134/276 (48%), Gaps = 9/276 (3%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+H AA+ + R LV A P A G TP H A+ GH++ ++ L SQG +
Sbjct: 464 PLHLAAQNNFENVARLLVSRQADPNLHEAE-GKTPLHVAAYFGHVSLVKLLTSQGA-ELD 521
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
+ + T LHLA G + LL G P A G P+H AAA+G + ++L+
Sbjct: 522 AQQRNLRTPLHLAVERGKVRAIQHLLK-SGAVPDALDQSGYGPLHTAAARGKYLICKMLL 580
Query: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
Y + T G TPL+LA +GHLE+ +L+ E A+ A TPLH AA+ G
Sbjct: 581 R-YGASLELPTHQGWTPLHLAAYKGHLEII-HLLAESHANMGALGAVNWTPLHLAARHGE 638
Query: 219 SPVIVWLVSC-TDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPL 276
V+ L+ C D + +EQ G T +H A R + LL H + A + G TP
Sbjct: 639 EAVVSALLQCGADPNAAEQS--GWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPA 696
Query: 277 HDAAENGELECCQILVVNGAELDVRDRDGYTAADLS 312
H AA G ++LV GA+LDV+D T L+
Sbjct: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732
Score = 101 bits (251), Expect = 3e-21
Identities = 84/261 (32%), Positives = 120/261 (45%), Gaps = 8/261 (3%)
Query: 7 LQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAAR 66
L A Q + + L + P+L + P+H AA G + ++ L + A A+
Sbjct: 465 LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGA-ELDAQ 523
Query: 67 ARNGATPAHDASATGHLACLQWLLSQGGCRVQDK-DNSGATVLHLAARFGHPEVVNWLLH 125
RN TP H A G + +Q LL G V D D SG LH AA G + LL
Sbjct: 524 QRNLRTPLHLAVERGKVRAIQHLLKSGA--VPDALDQSGYGPLHTAAARGKYLICKMLLR 581
Query: 126 HGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHL 185
+G T G P+H AA KG + LL E + + A TPL+LA + G
Sbjct: 582 YGAS-LELPTHQGWTPLHLAAYKGHLEIIHLLAESHAN-MGALGAVNWTPLHLAARHGEE 639
Query: 186 EVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMH 245
V L+Q CGADP+A G TPLH A Q ++ L+ ++ ++K G T H
Sbjct: 640 AVVSALLQ-CGADPNAAEQSGWTPLHLAVQRSTFLSVINLLE-HHANVHARNKVGWTPAH 697
Query: 246 FAASRGHTKVLSWLLLHGGEI 266
AA +G+T +L L+ G ++
Sbjct: 698 LAALKGNTAILKVLVEAGAQL 718
Score = 90.5 bits (223), Expect = 6e-18
Identities = 84/290 (28%), Positives = 137/290 (47%), Gaps = 13/290 (4%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLS-QGGCRV 97
P+H AA+ G R L++ A A+ R G TP H A+ + L+S Q +
Sbjct: 431 PLHFAAQNGDDGTARLLLDHGAC-VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNL 489
Query: 98 QDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLL 157
+ + G T LH+AA FGH +V LL G + A P+H A +G +++ L
Sbjct: 490 HEAE--GKTPLHVAAYFGHVSLVK-LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHL 546
Query: 158 VEH--YPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQ 215
++ P+ ++ ++G PL+ A G + + L++ GA H G TPLH AA
Sbjct: 547 LKSGAVPDALD---QSGYGPLHTAAARGKYLICKMLLRY-GASLELPTHQGWTPLHLAAY 602
Query: 216 MGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGT 274
GH +I L++ + ++ T +H AA G V+S LL G + +A + G T
Sbjct: 603 KGHLEII-HLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWT 661
Query: 275 PLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
PLH A + L+ + A + R++ G+T A L+ G++ + L
Sbjct: 662 PLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVL 711
Score = 82.4 bits (202), Expect = 2e-15
Identities = 60/188 (31%), Positives = 92/188 (48%), Gaps = 10/188 (5%)
Query: 141 PIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPH 200
P+H+ A+G +RLL+ H + V+ QT +G TPL +A Q+ ++ L+ GAD +
Sbjct: 365 PLHFLVAQGSVEQVRLLLAHEVD-VDCQTASGYTPLLIAAQDQQPDLCALLLAH-GADAN 422
Query: 201 ARAHDGMTPLHAAAQMGHSPVIVWLV---SCTDVSLSEQDKDGATAMHFAASRGHTKVLS 257
DG PLH AAQ G L+ +C D Q+++G T +H AA V
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDA----QEREGWTPLHLAAQNNFENVAR 478
Query: 258 WLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNG 316
L+ + + + G TPLH AA G + ++L GAELD + R+ T L+ G
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 538
Query: 317 HSHCTRYL 324
++L
Sbjct: 539 KVRAIQHL 546
Score = 53.5 bits (127), Expect = 8e-07
Identities = 38/119 (31%), Positives = 60/119 (50%), Gaps = 2/119 (1%)
Query: 207 MTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEI 266
+TPLH G S V L+ +V + Q G T + AA + + LL HG +
Sbjct: 363 VTPLHFLVAQG-SVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421
Query: 267 S-ADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
+ D G PLH AA+NG+ ++L+ +GA +D ++R+G+T L+ N + R L
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 121 bits (303), Expect = 3e-27
Identities = 111/329 (33%), Positives = 154/329 (46%), Gaps = 15/329 (4%)
Query: 9 AARQGELDVLRSLHAAGL-LGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
AARQG V+ L G + + +D AL AA G + L+ A A
Sbjct: 585 AARQGHTKVVNCLIGCGANINHTDQDGWTAL--RSAAWGGHTEVVSALLYAGVKVDCADA 642
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
+ T A+ GH + LL Q G V DN G T L AA GH E+V LL HG
Sbjct: 643 -DSRTALRAAAWGGHEDIVLNLL-QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
Query: 128 GG----DPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEG 183
D T + + A+KG + LL++ E V+ K+G TPL +A EG
Sbjct: 701 AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE-VDHCDKDGMTPLLVAAYEG 759
Query: 184 HLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATA 243
H++V L+ E GAD ++G TPL AAA MGH+ V+ L+ ++ D +G T
Sbjct: 760 HVDVVDLLL-EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW-GAAVDSIDSEGRTV 817
Query: 244 MHFAASRGHTKVLSWLLLHG-GEISADLWGGTPLHDAAENGELECCQILVVNGAELDVRD 302
+ A+++G+ +V+ LL G E D G TPLH AA G C+ L+ GA + D
Sbjct: 818 LSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEID 877
Query: 303 RDGYTAADLSDFNGHSHCTRYLRTVENLS 331
DG L+ GH C + L +EN S
Sbjct: 878 NDGRIPFILASQEGHYDCVQIL--LENKS 904
Score = 109 bits (272), Expect = 1e-23
Identities = 108/372 (29%), Positives = 169/372 (45%), Gaps = 18/372 (4%)
Query: 7 LQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAAR 66
L AA G V+ +L G S+ D + A+ G + +R L++ L R
Sbjct: 786 LAAASMGHASVVNTLLFWGAAVDSI-DSEGRTVLSIASAQGNVEVVRTLLDRG-LDENHR 843
Query: 67 ARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHH 126
G TP H A+ GH + L+ QG R + DN G LA++ GH + V LL +
Sbjct: 844 DDAGWTPLHMAAFEGHRLICEALIEQGA-RTNEIDNDGRIPFILASQEGHYDCVQILLEN 902
Query: 127 GGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLE 186
D G + AA +G + LL H + VN + +G LY+ E L
Sbjct: 903 KSNIDQRGYD-GRNALRVAALEGHRDIVELLFSHGAD-VNCKDADGRPTLYILALENQLT 960
Query: 187 VTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSC-TDVSLSEQDKDGATAMH 245
+ +Y ++ GA+ A +G T LH + GH ++ L++ DV+ ++ +K +A+
Sbjct: 961 MAEYFLEN-GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEK--RSALQ 1017
Query: 246 FAASRGHTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRD 304
AA +GH KV+ L+ HG + G T L AA+ G ++ Q+L+ +GA+ + D+
Sbjct: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
Query: 305 GYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQ 364
G TA ++ NGHS + L S+ S P +E K P +SS VQ
Sbjct: 1078 GRTAMRVAAKNGHSQIIKLLEKYGASSLNG--CSPSPVHTMEQK-PLQSLSS-----KVQ 1129
Query: 365 PLNFDLSSPTST 376
L +S ST
Sbjct: 1130 SLTIKSNSSGST 1141
Score = 97.4 bits (241), Expect = 5e-20
Identities = 88/286 (30%), Positives = 137/286 (47%), Gaps = 15/286 (5%)
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
NG T +A+ +G L + L+S+G ++ +D G T L LAAR GH +VVN L+ G
Sbjct: 544 NGRTLLANAAYSGSLDVVNLLVSRGA-DLEIEDAHGHTPLTLAARQGHTKVVNCLI--GC 600
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
G TD +AA G + + + V+ + T L A GH ++
Sbjct: 601 GANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV 660
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFA- 247
L+Q GA+ + ++G T L AAA MGH ++ L+ ++ +D DG TA+ A
Sbjct: 661 LNLLQH-GAEVNKADNEGRTALIAAAYMGHREIVEHLLD-HGAEVNHEDVDGRTALSVAA 718
Query: 248 ----ASRGHTKVLSWLLLHGGEIS-ADLWGGTPLHDAAENGELECCQILVVNGAELDVRD 302
AS+GH V+S L+ G E+ D G TPL AA G ++ +L+ GA++D D
Sbjct: 719 LCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTD 778
Query: 303 RDGYTAADLSDFNGHSHCTRYL----RTVENLSVEHRVLSRDPSAE 344
+G T + GH+ L V+++ E R + SA+
Sbjct: 779 NNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQ 824
Score = 48.9 bits (115), Expect = 2e-05
Identities = 39/134 (29%), Positives = 62/134 (46%), Gaps = 5/134 (3%)
Query: 186 EVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMH 245
EV Q LV+ A H + D T + I L+ S+++ D +G T +
Sbjct: 495 EVLQLLVK---AGAHVNSEDDRTSCIVRQALEREDSIRTLLD-NGASVNQCDSNGRTLLA 550
Query: 246 FAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDRD 304
AA G V++ L+ G ++ D G TPL AA G + L+ GA ++ D+D
Sbjct: 551 NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
Query: 305 GYTAADLSDFNGHS 318
G+TA + + GH+
Sbjct: 611 GWTALRSAAWGGHT 624
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 120 bits (300), Expect = 7e-27
Identities = 103/333 (30%), Positives = 152/333 (45%), Gaps = 46/333 (13%)
Query: 27 LGPSLRDPLDALP--------VHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDAS 78
LGP P +P + A R G + ++ LV+ A + A A ++P H A+
Sbjct: 165 LGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAA 224
Query: 79 ATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMG 138
G ++ LL Q G V +D+ G LH A FGH EVV+ LL G DP A +
Sbjct: 225 GFGRKDVVEHLL-QMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGA-DPNARDNWN 282
Query: 139 ALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLA------------------- 179
P+H AA KG +L++H + N + +G + L LA
Sbjct: 283 YTPLHEAAIKGKIDVCIVLLQHGADP-NIRNTDGKSALDLADPSAKAVLTGEYKKDELLE 341
Query: 180 -CQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPV-IVWLVSCTDVSLSEQD 237
+ G+ E L+ + HA TPLH AA G++ V IV L+ + +D
Sbjct: 342 AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAA--GYNRVRIVQLLLQHGADVHAKD 399
Query: 238 KDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGA 296
K G +H A S GH +V LL HG ++A DLW TPLH+AA +E C +L+ +GA
Sbjct: 400 KGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA 459
Query: 297 ELDVRDRDGYTAADLS-----------DFNGHS 318
+ + + G +A D++ +F GHS
Sbjct: 460 DPTLVNCHGKSAVDMAPTPELRERLTYEFKGHS 492
Score = 114 bits (285), Expect = 4e-25
Identities = 86/293 (29%), Positives = 140/293 (47%), Gaps = 29/293 (9%)
Query: 43 AARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDN 102
A++AG L ++ L + +TP H A+ ++ +++LL G V KD
Sbjct: 657 ASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGA-DVHAKDK 715
Query: 103 SGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGAL-PIHYAAAKGDFPSLRLLVEHY 161
G LH A +GH EV L+ HG A D+ P+H AAAKG + +LL++H
Sbjct: 716 GGLVPLHNACSYGHYEVAELLVRHGASVNVA--DLWKFTPLHEAAAKGKYEICKLLLKHG 773
Query: 162 PEGVNAQTKNGATPLYLACQEGHLEVTQYL-----------------VQECGADPHARAH 204
+ + ++G TPL L +EG ++ L VQ+ +
Sbjct: 774 ADPTK-KNRDGNTPLDLV-KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCR 831
Query: 205 D----GMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLL 260
D TPLH AA + V +L+ ++ QDK G +H AAS GH + + L+
Sbjct: 832 DTQGRNSTPLHLAAGYNNLEVAEYLLE-HGADVNAQDKGGLIPLHNAASYGHVDIAALLI 890
Query: 261 LHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLS 312
+ ++A D W TPLH+AA+ G + C +L+ +GA+ +++++G T DL+
Sbjct: 891 KYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 107 bits (268), Expect = 4e-23
Identities = 95/310 (30%), Positives = 143/310 (46%), Gaps = 19/310 (6%)
Query: 7 LQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAAR 66
LQAAR+ +L ++ A ++ + + P H A A LH R V E L A
Sbjct: 494 LQAAREADLAKVKKTLALEII--NFKQPQSHETALHCAVAS-LHPKRKQVTELLLRKGAN 550
Query: 67 A----RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNW 122
++ TP H A+ H ++ +L + G ++ D G T LH AA GH +
Sbjct: 551 VNEKNKDFMTPLHVAAERAHNDVME-VLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609
Query: 123 LLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQE 182
LL +G DP+ + G AA G+ ++L E P +T + L A +
Sbjct: 610 LLSYGS-DPSIISLQGFT----AAQMGNEAVQQILSESTP----IRTSDVDYRLLEASKA 660
Query: 183 GHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGAT 242
G LE + L + TPLH AA V+ +L+ + +DK G
Sbjct: 661 GDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLH-HGADVHAKDKGGLV 719
Query: 243 AMHFAASRGHTKVLSWLLLHGGEIS-ADLWGGTPLHDAAENGELECCQILVVNGAELDVR 301
+H A S GH +V L+ HG ++ ADLW TPLH+AA G+ E C++L+ +GA+ +
Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK 779
Query: 302 DRDGYTAADL 311
+RDG T DL
Sbjct: 780 NRDGNTPLDL 789
Score = 101 bits (251), Expect = 3e-21
Identities = 96/347 (27%), Positives = 155/347 (44%), Gaps = 23/347 (6%)
Query: 4 EQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPA 63
++ L+AAR G + L +L + D + P+H AA ++ ++ L++ A
Sbjct: 337 DELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGA-DV 395
Query: 64 AARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWL 123
A+ + G P H+A + GH + LL G C V D T LH AA EV + L
Sbjct: 396 HAKDKGGLVPLHNACSYGHYEVTELLLKHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLL 454
Query: 124 LHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEG 183
L HG DPT G + A P LR + + +G + L A +E
Sbjct: 455 LSHGA-DPTLVNCHGKSAVDMAPT----PELRERLTYEFKGHS---------LLQAAREA 500
Query: 184 HL-EVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSP--VIVWLVSCTDVSLSEQDKDG 240
L +V + L E ++H+ T LH A H + L+ +++E++KD
Sbjct: 501 DLAKVKKTLALEIINFKQPQSHE--TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDF 558
Query: 241 ATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELD 299
T +H AA R H V+ L HG +++A D G T LH AA G L+ C++L+ G++
Sbjct: 559 MTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPS 618
Query: 300 VRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELE 346
+ G+TAA + + + V++R+L + +LE
Sbjct: 619 IISLQGFTAAQMGN-EAVQQILSESTPIRTSDVDYRLLEASKAGDLE 664
Score = 95.1 bits (235), Expect = 2e-19
Identities = 99/336 (29%), Positives = 141/336 (41%), Gaps = 45/336 (13%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPA----- 63
AA + DV+ LH G +L D L +H AA AG L R L+ + P+
Sbjct: 565 AAERAHNDVMEVLHKHGAKMNAL-DTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQ 623
Query: 64 ---AARARNGA--------TPAH---------DASATGHLACLQWLLSQGGCRVQDKDNS 103
AA+ N A TP +AS G L ++ L S +D +
Sbjct: 624 GFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGR 683
Query: 104 GATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPE 163
+T LH AA + VV +LLHHG D A G +P+H A + G + LLV H
Sbjct: 684 HSTPLHFAAGYNRVSVVEYLLHHGA-DVHAKDKGGLVPLHNACSYGHYEVAELLVRH-GA 741
Query: 164 GVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIV 223
VN TPL+ A +G E+ + L++ GADP + DG TPL
Sbjct: 742 SVNVADLWKFTPLHEAAAKGKYEICKLLLKH-GADPTKKNRDGNTPLD------------ 788
Query: 224 WLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWG--GTPLHDAAE 281
LV D + + + G A+ AA +G + L D G TPLH AA
Sbjct: 789 -LVKEGDTDIQDLLR-GDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAG 846
Query: 282 NGELECCQILVVNGAELDVRDRDGYTAADLSDFNGH 317
LE + L+ +GA+++ +D+ G + GH
Sbjct: 847 YNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGH 882
Score = 38.1 bits (87), Expect = 0.035
Identities = 45/184 (24%), Positives = 70/184 (38%), Gaps = 34/184 (18%)
Query: 539 HSEEVRARQPARAGC----PRLGPAARGSLEG--PSAPPQAALLPGNHVPNGCAADPKAS 592
H + QPA P P + G G P++P + L P +G A
Sbjct: 11 HHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDG 70
Query: 593 RELPPPPPPPPPPLPEAA-----------SSPPPAPPLPLESAG------PGCGQRRSSS 635
PP P P P+ + ++ P P + SA G G S S
Sbjct: 71 SRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPS 130
Query: 636 STGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGIGQPAFQPDSPLPSV 695
S+ S S + SP+ G SL +P++ G+++ + +G A P + +P+V
Sbjct: 131 SSSSPTSSSSSSPS----------SPGSSLAESPEAAGVSST-APLGPGAAGPGTGVPAV 179
Query: 696 SPAL 699
S AL
Sbjct: 180 SGAL 183
Score = 38.1 bits (87), Expect = 0.035
Identities = 51/201 (25%), Positives = 67/201 (33%), Gaps = 47/201 (23%)
Query: 431 PPPPPSFPPPPPPPGTQLPPPPPGYPAPKPPVGPQAADI--YMQTKNKLRHVETEALKKE 488
P P S PPPPPP PP PG P P A+ + + ++ L
Sbjct: 20 PAPGASAPPPPPP-----PPLSPGLAPGTTPASPTASGLAPFASPRHGL----------- 63
Query: 489 LSSCDGHDGLRRQDSSRKPRAFSKQPSTGDYYRQLGRCPGETLAARPGMAHSEEVRARQP 548
L D SR P + P D G T + +A + V A
Sbjct: 64 --------ALPEGDGSRDPPDRPRSPDPVD-----GTSCCSTTSTICTVAAAPVVPAVST 110
Query: 549 ARAGCPRLGPAARGSLEGPSAPPQAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPE 608
+ A PA GS N+ P+ ++ +S P P PE
Sbjct: 111 SSAAGVAPNPAGSGS---------------NNSPSSSSSPTSSSSSSPSSPGSSLAESPE 155
Query: 609 AASSPPPAPPLPLESAGPGCG 629
AA AP P +AGPG G
Sbjct: 156 AAGVSSTAPLGP-GAAGPGTG 175
>gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens]
Length = 361
Score = 119 bits (298), Expect = 1e-26
Identities = 96/318 (30%), Positives = 148/318 (46%), Gaps = 10/318 (3%)
Query: 11 RQGELDVLRS-LHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARN 69
++G L L+ L AAG D L +H AAR G L +L E + A R+
Sbjct: 15 QEGRLRALKEELQAAGGCPGPAGDTL----LHCAARHGHRDVLAYLAEAWGMDIEATNRD 70
Query: 70 GATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGG 129
P H+A++ GH C+++LL +G V + T L +A + V+ L+ HG
Sbjct: 71 YKRPLHEAASMGHRDCVRYLLGRGAA-VDCLKKADWTPLMMACTRKNLGVIQELVEHGA- 128
Query: 130 DPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQ 189
+P G H A+ +GD L+ L+ P ++K TPL+ A GHLE +
Sbjct: 129 NPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVK 188
Query: 190 YLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAAS 249
L++ C +P R + G+T L A Q GH V L+ LS +D GA A+H AA
Sbjct: 189 VLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAV 248
Query: 250 RGHTKVLSWLLLHGG---EISADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGY 306
G + + +L+ G ++ A T LH AA+ G Q L+ GA+++ +D
Sbjct: 249 TGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNR 308
Query: 307 TAADLSDFNGHSHCTRYL 324
+A L+ H C ++L
Sbjct: 309 SALHLACAGQHLACAKFL 326
Score = 71.6 bits (174), Expect = 3e-12
Identities = 51/186 (27%), Positives = 87/186 (46%), Gaps = 2/186 (1%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
A+R+G+ +L+ L + P+H AA G L ++ L++ R
Sbjct: 144 ASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDN 203
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G T DA GH+ + LL + G + +D+ GA LH AA G E + +L+ G
Sbjct: 204 CGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELG 263
Query: 129 GD-PTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEV 187
D AT +HYAA +G +++ L+ + +N++ + + L+LAC HL
Sbjct: 264 VDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGAD-INSKDEKNRSALHLACAGQHLAC 322
Query: 188 TQYLVQ 193
++L+Q
Sbjct: 323 AKFLLQ 328
Score = 60.5 bits (145), Expect = 7e-09
Identities = 47/151 (31%), Positives = 70/151 (46%), Gaps = 10/151 (6%)
Query: 181 QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDG 240
QEG L + +Q G P G T LH AA+ GH V+ +L + + ++D
Sbjct: 15 QEGRLRALKEELQAAGGCPGPA---GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY 71
Query: 241 ATAMHFAASRGHTKVLSWLLLHGGEIS----ADLWGGTPLHDAAENGELECCQILVVNGA 296
+H AAS GH + +LL G + AD W TPL A L Q LV +GA
Sbjct: 72 KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKAD-W--TPLMMACTRKNLGVIQELVEHGA 128
Query: 297 ELDVRDRDGYTAADLSDFNGHSHCTRYLRTV 327
++++DG+ + ++ G +YL TV
Sbjct: 129 NPLLKNKDGWNSFHIASREGDPLILQYLLTV 159
Score = 56.2 bits (134), Expect = 1e-07
Identities = 44/125 (35%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 7 LQAARQGELDVLRSL---HAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPA 63
+ A + G +DV R L H A L S D L A +H AA G+ +RFLV E +
Sbjct: 210 MDAIQCGHIDVARLLLDEHGACL---SAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDV 266
Query: 64 AARARNG-ATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNW 122
RA + T H A+ GH + +Q LLS G + KD + LHLA H +
Sbjct: 267 DVRATSTHLTALHYAAKEGHTSTIQTLLSLGA-DINSKDEKNRSALHLACAGQHLACAKF 325
Query: 123 LLHHG 127
LL G
Sbjct: 326 LLQSG 330
>gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens]
Length = 361
Score = 119 bits (298), Expect = 1e-26
Identities = 96/318 (30%), Positives = 148/318 (46%), Gaps = 10/318 (3%)
Query: 11 RQGELDVLRS-LHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARN 69
++G L L+ L AAG D L +H AAR G L +L E + A R+
Sbjct: 15 QEGRLRALKEELQAAGGCPGPAGDTL----LHCAARHGHRDVLAYLAEAWGMDIEATNRD 70
Query: 70 GATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGG 129
P H+A++ GH C+++LL +G V + T L +A + V+ L+ HG
Sbjct: 71 YKRPLHEAASMGHRDCVRYLLGRGAA-VDCLKKADWTPLMMACTRKNLGVIQELVEHGA- 128
Query: 130 DPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQ 189
+P G H A+ +GD L+ L+ P ++K TPL+ A GHLE +
Sbjct: 129 NPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVK 188
Query: 190 YLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAAS 249
L++ C +P R + G+T L A Q GH V L+ LS +D GA A+H AA
Sbjct: 189 VLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAV 248
Query: 250 RGHTKVLSWLLLHGG---EISADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGY 306
G + + +L+ G ++ A T LH AA+ G Q L+ GA+++ +D
Sbjct: 249 TGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNR 308
Query: 307 TAADLSDFNGHSHCTRYL 324
+A L+ H C ++L
Sbjct: 309 SALHLACAGQHLACAKFL 326
Score = 71.6 bits (174), Expect = 3e-12
Identities = 51/186 (27%), Positives = 87/186 (46%), Gaps = 2/186 (1%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
A+R+G+ +L+ L + P+H AA G L ++ L++ R
Sbjct: 144 ASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDN 203
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G T DA GH+ + LL + G + +D+ GA LH AA G E + +L+ G
Sbjct: 204 CGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELG 263
Query: 129 GD-PTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEV 187
D AT +HYAA +G +++ L+ + +N++ + + L+LAC HL
Sbjct: 264 VDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGAD-INSKDEKNRSALHLACAGQHLAC 322
Query: 188 TQYLVQ 193
++L+Q
Sbjct: 323 AKFLLQ 328
Score = 60.5 bits (145), Expect = 7e-09
Identities = 47/151 (31%), Positives = 70/151 (46%), Gaps = 10/151 (6%)
Query: 181 QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDG 240
QEG L + +Q G P G T LH AA+ GH V+ +L + + ++D
Sbjct: 15 QEGRLRALKEELQAAGGCPGPA---GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY 71
Query: 241 ATAMHFAASRGHTKVLSWLLLHGGEIS----ADLWGGTPLHDAAENGELECCQILVVNGA 296
+H AAS GH + +LL G + AD W TPL A L Q LV +GA
Sbjct: 72 KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKAD-W--TPLMMACTRKNLGVIQELVEHGA 128
Query: 297 ELDVRDRDGYTAADLSDFNGHSHCTRYLRTV 327
++++DG+ + ++ G +YL TV
Sbjct: 129 NPLLKNKDGWNSFHIASREGDPLILQYLLTV 159
Score = 56.2 bits (134), Expect = 1e-07
Identities = 44/125 (35%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 7 LQAARQGELDVLRSL---HAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPA 63
+ A + G +DV R L H A L S D L A +H AA G+ +RFLV E +
Sbjct: 210 MDAIQCGHIDVARLLLDEHGACL---SAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDV 266
Query: 64 AARARNG-ATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNW 122
RA + T H A+ GH + +Q LLS G + KD + LHLA H +
Sbjct: 267 DVRATSTHLTALHYAAKEGHTSTIQTLLSLGA-DINSKDEKNRSALHLACAGQHLACAKF 325
Query: 123 LLHHG 127
LL G
Sbjct: 326 LLQSG 330
>gi|140161500 ankyrin repeat and sterile alpha motif domain
containing 1 [Homo sapiens]
Length = 1134
Score = 117 bits (293), Expect = 5e-26
Identities = 103/355 (29%), Positives = 156/355 (43%), Gaps = 17/355 (4%)
Query: 94 GCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPS 153
G V D++G T LH AA GH +VV LL + A G P+H AA KGD
Sbjct: 70 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALT-NVADSKGCYPLHLAAWKGDAQI 128
Query: 154 LRLLVEHYPEG--VNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLH 211
+RLL+ P VN Q + T L+ A Q GH EV + L++E DP R + TPL
Sbjct: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEEL-TDPTMRNNKFETPLD 187
Query: 212 AAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLW 271
AA G V+ L++ LS K T +H AA GH V+ LL G + +
Sbjct: 188 LAALYGRLEVVKMLLNAHPNLLSCNTKKH-TPLHLAARNGHKAVVQVLLDAGMDSNYQTE 246
Query: 272 GGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLS 331
G+ LH+AA G+ + QIL+ G +++++D G TA D ++ + + L
Sbjct: 247 MGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALD----TVRELPSQKSQQIAALI 302
Query: 332 VEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSSHSSIK 391
+H R + P + S ++S + + T + ++D+ + +
Sbjct: 303 EDHMTGKRSTKEVDKTPPPQPPLISSMDSISQKSQGDVEKAVTELIIDFDANAEEEGPYE 362
Query: 392 GQ------HPPCGLSSARAADIQSYMDMLNPELGLPRGTIGKPTPPPPPPSFPPP 440
H ++S R++D S P G +P PPPP+ PPP
Sbjct: 363 ALYNAISCHSLDSMASGRSSDQDSTNKEAEAAGVKPAGV--RPRERPPPPAKPPP 415
Score = 94.0 bits (232), Expect = 5e-19
Identities = 74/222 (33%), Positives = 114/222 (51%), Gaps = 12/222 (5%)
Query: 28 GPSLR--DPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLAC 85
GP++ D P+HHAA G + L+ AL A ++ G P H A+ G
Sbjct: 70 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK-GCYPLHLAAWKGDAQI 128
Query: 86 LQWLLSQG--GCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIH 143
++ L+ QG RV +++N T LH AA++GH EVV LL DPT + P+
Sbjct: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEE-LTDPTMRNNKFETPLD 187
Query: 144 YAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARA 203
AA G +++L+ +P ++ TK TPL+LA + GH V Q L+ + G D + +
Sbjct: 188 LAALYGRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLL-DAGMDSNYQT 245
Query: 204 HDGMTPLHAAAQMGHSPVI-VWLVSCTDVSLSEQDKDGATAM 244
G + LH AA G + V+ + L + TDV++ +D G TA+
Sbjct: 246 EMG-SALHEAALFGKTDVVQILLAAGTDVNI--KDNHGLTAL 284
Score = 40.8 bits (94), Expect = 0.005
Identities = 36/119 (30%), Positives = 55/119 (46%), Gaps = 4/119 (3%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AA+ G +V++ L L P++R+ P+ AA G+L ++ L+ + +
Sbjct: 156 AAQYGHTEVVKVL-LEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTK 214
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
TP H A+ GH A +Q LL G + + LH AA FG +VV LL G
Sbjct: 215 KH-TPLHLAARNGHKAVVQVLLDAG--MDSNYQTEMGSALHEAALFGKTDVVQILLAAG 270
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 116 bits (290), Expect = 1e-25
Identities = 95/320 (29%), Positives = 152/320 (47%), Gaps = 9/320 (2%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AA G+ +++ L +G + +D + P+H A + ++ L++ +A AR +
Sbjct: 23 AAFLGDAEIIELLILSGAR-VNAKDNMWLTPLHRAVASRSEEAVQVLIKHSA-DVNARDK 80
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
N TP H A+A + C + ++ V D G T LH AA GH E+VN LL G
Sbjct: 81 NWQTPLHVAAANKAVKCAEVIIPLLSS-VNVSDRGGRTALHHAALNGHVEMVNLLLAKGA 139
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+ A +H+AA G + LL+ H E V + K G TPL+ A G + V
Sbjct: 140 -NINAFDKKDRRALHWAAYMGHLDVVALLINHGAE-VTCKDKKGYTPLHAAASNGQINVV 197
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
++L+ G + G T LH A G V+ L+ ++++ + +G T +HFAA
Sbjct: 198 KHLLN-LGVEIDEINVYGNTALHIACYNGQDAVVNELIDY-GANVNQPNNNGFTPLHFAA 255
Query: 249 SRGHTKV-LSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDGY 306
+ H + L L+ +G +++ G +PLH A +G Q L+ NG E+D D+DG
Sbjct: 256 ASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315
Query: 307 TAADLSDFNGHSHCTRYLRT 326
T ++ GH LRT
Sbjct: 316 TPLHVAARYGHELLINTLRT 335
Score = 111 bits (277), Expect = 3e-24
Identities = 93/317 (29%), Positives = 140/317 (44%), Gaps = 9/317 (2%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
A+R E + H+A + + RD P+H AA + C ++ + R
Sbjct: 58 ASRSEEAVQVLIKHSADV---NARDKNWQTPLHVAAANKAVKCAEVIIPLLS-SVNVSDR 113
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G T H A+ GH+ + LL++G + D LH AA GH +VV L++HG
Sbjct: 114 GGRTALHHAALNGHVEMVNLLLAKGA-NINAFDKKDRRALHWAAYMGHLDVVALLINHGA 172
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+ T G P+H AA+ G ++ L+ E ++ G T L++AC G V
Sbjct: 173 -EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVE-IDEINVYGNTALHIACYNGQDAVV 230
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
L+ + GA+ + ++G TPLH AA H + + L+ ++ Q KDG + +H A
Sbjct: 231 NELI-DYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTA 289
Query: 249 SRGHTKVLSWLLLHGGEIS-ADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYT 307
G L+ +GGEI D G TPLH AA G L +GA+
Sbjct: 290 VHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMF 349
Query: 308 AADLSDFNGHSHCTRYL 324
L+ N HS C R L
Sbjct: 350 PLHLAALNAHSDCCRKL 366
Score = 111 bits (277), Expect = 3e-24
Identities = 91/272 (33%), Positives = 125/272 (45%), Gaps = 12/272 (4%)
Query: 29 PSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGAT--PAHDASATGHLACL 86
PS+RD +H+AA G CL L+E + +GAT P H A+ GH L
Sbjct: 500 PSIRDKEGYNSIHYAAAYGHRQCLELLLERTN-SGFEESDSGATKSPLHLAAYNGHHQAL 558
Query: 87 QWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAA 146
+ LL Q + +D G T L LAA GH E V L++ G P+H +
Sbjct: 559 EVLL-QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASV 617
Query: 147 AKGDFPSLRLLVE--HYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAH 204
G LRLL+E PE V+ + G TPL LA GH++ L+++ A+
Sbjct: 618 INGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEK-EANVDTVDI 676
Query: 205 DGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGG 264
G T LH GH + L+ +VS+ +D G T +H+AA+RGH LS LL
Sbjct: 677 LGCTALHRGIMTGHEECVQMLLE-QEVSILCKDSRGRTPLHYAAARGHATWLSELLQMAL 735
Query: 265 E----ISADLWGGTPLHDAAENGELECCQILV 292
D G TPLH A NG C ++L+
Sbjct: 736 SEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
Score = 105 bits (263), Expect = 1e-22
Identities = 97/312 (31%), Positives = 133/312 (42%), Gaps = 25/312 (8%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGAT---PAHDASATGHLACLQWLLSQGGC 95
P+H AAR G L+ A A+ G P H A+ H C + LLS G
Sbjct: 317 PLHVAARYGH----ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG-F 371
Query: 96 RVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLR 155
+ D G T LH AA G+ E + LL G D G P+HYAAA F +
Sbjct: 372 EIDTPDKFGRTCLHAAAAGGNVECIK-LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIE 430
Query: 156 LLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQ 215
LV VN G T L+ A L AHD L A +
Sbjct: 431 TLVTT-GANVNETDDWGRTALHYAAASDMDRNKTIL---------GNAHDNSEELERARE 480
Query: 216 MGHSPVIVWL--VSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLH---GGEISADL 270
+ + L + D + S +DK+G ++H+AA+ GH + L LL G E S
Sbjct: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
Query: 271 WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL-RTVEN 329
+PLH AA NG + ++L+ + +LD+RD G TA DL+ F GH+ C L +
Sbjct: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
Query: 330 LSVEHRVLSRDP 341
+ V+ V R P
Sbjct: 601 IFVKDNVTKRTP 612
Score = 104 bits (259), Expect = 4e-22
Identities = 96/290 (33%), Positives = 128/290 (44%), Gaps = 13/290 (4%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARN--GATPAHDASATGHLACLQWLLSQGGCR 96
P+H + G CLR L+E A P A ++ G TP A A GH+ + LL +
Sbjct: 612 PLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA-N 670
Query: 97 VQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRL 156
V D G T LH GH E V LL G P+HYAAA+G L
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSI-LCKDSRGRTPLHYAAARGHATWLSE 729
Query: 157 LVEHY--PEGVNAQTKNGATPLYLACQEGHLEVTQYLV-QECGADPHARAHDGMTPLHAA 213
L++ E + G TPL+ AC G+ + L+ Q+C + TPLH A
Sbjct: 730 LLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCF---RKFIGNPFTPLHCA 786
Query: 214 AQMGHSPVIVWLVSCTDVSL-SEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLW 271
H L+ D S+ S +D G T + AA H + L LL H ++A D
Sbjct: 787 IINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNS 846
Query: 272 GGTPLHDAAENGELECCQILVVNG-AELDVRDRDGYTAADLSDFNGHSHC 320
G T L AAENG+ ILV + A+L V+D+D T L+ GH C
Sbjct: 847 GKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896
Score = 100 bits (249), Expect = 6e-21
Identities = 70/221 (31%), Positives = 116/221 (52%), Gaps = 5/221 (2%)
Query: 97 VQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRL 156
V D+ T LH+AA G E++ LL G A +M P+H A A ++++
Sbjct: 9 VNTLDSEKRTPLHVAAFLGDAEIIE-LLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 157 LVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQM 216
L++H + VNA+ KN TPL++A ++ + ++ + + G T LH AA
Sbjct: 68 LIKHSAD-VNARDKNWQTPLHVAAANKAVKCAEVIIPLL-SSVNVSDRGGRTALHHAALN 125
Query: 217 GHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTP 275
GH ++ L++ +++ DK A+H+AA GH V++ L+ HG E++ D G TP
Sbjct: 126 GHVEMVNLLLA-KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTP 184
Query: 276 LHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNG 316
LH AA NG++ + L+ G E+D + G TA ++ +NG
Sbjct: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNG 225
Score = 76.6 bits (187), Expect = 9e-14
Identities = 70/232 (30%), Positives = 98/232 (42%), Gaps = 21/232 (9%)
Query: 33 DPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLA----CLQW 88
D L +H G C++ L+E+ +R G TP H A+A GH LQ
Sbjct: 675 DILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSR-GRTPLHYAAARGHATWLSELLQM 733
Query: 89 LLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG-----GDPTAATDMGALPIH 143
LS+ C KDN G T LH A G+ + LL G+P P+H
Sbjct: 734 ALSEEDCCF--KDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFT-------PLH 784
Query: 144 YAAAKGDFPSLRLLVEHYPEG-VNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHAR 202
A LL+ V+ + G TPL A H+E Q L++ A +A
Sbjct: 785 CAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH-SAPVNAV 843
Query: 203 AHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTK 254
+ G T L AA+ G + + LV+ L+ +DKD T +H A S+GH K
Sbjct: 844 DNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEK 895
Score = 47.0 bits (110), Expect = 8e-05
Identities = 34/110 (30%), Positives = 47/110 (42%), Gaps = 1/110 (0%)
Query: 64 AARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWL 123
+ R G TP A+ H+ CLQ LL V DNSG T L +AA G V+ L
Sbjct: 808 SCRDDKGRTPLRAAAFADHVECLQLLLRHSA-PVNAVDNSGKTALMMAAENGQAGAVDIL 866
Query: 124 LHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGA 173
++ D T P+H A +KG L+++ + KN A
Sbjct: 867 VNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNA 916
Score = 32.3 bits (72), Expect = 1.9
Identities = 29/137 (21%), Positives = 56/137 (40%), Gaps = 10/137 (7%)
Query: 274 TPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVE 333
TPLH AA G+ E ++L+++GA ++ +D T H + ++
Sbjct: 18 TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPL-------HRAVASRSEEAVQVLIK 70
Query: 334 HRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQ 393
H S D +A + Q +++ N V + L S + + H+++ G
Sbjct: 71 H---SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
Query: 394 HPPCGLSSARAADIQSY 410
L A+ A+I ++
Sbjct: 128 VEMVNLLLAKGANINAF 144
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 115 bits (288), Expect = 2e-25
Identities = 90/284 (31%), Positives = 137/284 (48%), Gaps = 11/284 (3%)
Query: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
P+ AA G + L+ L++ + + + G+ + A+ GH+ L++L S+ C +
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSR-IDVQDKGGSNAVYWAARHGHVDTLKFL-SENKCPLD 439
Query: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
KD SG LH+AAR+GH +V LL G +P P+H AA G + + L
Sbjct: 440 VKDKSGEMALHVAARYGHADVAQ-LLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALC 498
Query: 159 EHYPEGVNAQTKN--GATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQM 216
E G N KN G TPL A G+ ++ + L + GAD +A DG LH A +
Sbjct: 499 E---AGCNVNIKNREGETPLLTASARGYHDIVECLAEH-GADLNACDKDGHIALHLAVRR 554
Query: 217 GHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEIS-ADLWGGTP 275
VI L+S + QD+ G T +H A G+ ++ L + ++ +G TP
Sbjct: 555 CQMEVIKTLLS-QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTP 613
Query: 276 LHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSH 319
LH AA NG L+ + L + GA ++ DG TA DL+ H H
Sbjct: 614 LHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEH 657
Score = 99.0 bits (245), Expect = 2e-20
Identities = 77/259 (29%), Positives = 120/259 (46%), Gaps = 8/259 (3%)
Query: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
++G P A+ G++ LQ L+ +G R+ +D G+ ++ AAR GH + + +L +
Sbjct: 377 KHGTPPLLIAAGCGNIQILQLLIKRGS-RIDVQDKGGSNAVYWAARHGHVDTLKFLSENK 435
Query: 128 GGDPTAATDM-GALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLE 186
P D G + +H AA G +LL + N Q K TPL+ A G+
Sbjct: 436 C--PLDVKDKSGEMALHVAARYGHADVAQLLCS-FGSNPNIQDKEEETPLHCAAWHGYYS 492
Query: 187 VTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHF 246
V + L E G + + + +G TPL A+ G+ ++ L L+ DKDG A+H
Sbjct: 493 VAKALC-EAGCNVNIKNREGETPLLTASARGYHDIVECLAE-HGADLNACDKDGHIALHL 550
Query: 247 AASRGHTKVLSWLLLHGGEIS-ADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDG 305
A R +V+ LL G + D G TPLH A ++G + L LD+ ++ G
Sbjct: 551 AVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYG 610
Query: 306 YTAADLSDFNGHSHCTRYL 324
T L+ NG RYL
Sbjct: 611 RTPLHLAANNGILDVVRYL 629
Score = 35.4 bits (80), Expect = 0.23
Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 3/102 (2%)
Query: 226 VSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLL--LHGGEISADLWGGTP-LHDAAEN 282
V+ +D +L E+D A+ A + + L LL L +++ GTP L AA
Sbjct: 330 VARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGC 389
Query: 283 GELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
G ++ Q+L+ G+ +DV+D+ G A + +GH ++L
Sbjct: 390 GNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 115 bits (287), Expect = 2e-25
Identities = 97/327 (29%), Positives = 146/327 (44%), Gaps = 18/327 (5%)
Query: 3 LEQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALP 62
L +A+ + + + VL H+A + + RD P+H AA + C EA +P
Sbjct: 78 LHRAVASCSEEAVQVLLK-HSADV---NARDKNWQTPLHIAAANKAVKCA-----EALVP 128
Query: 63 AAARA----RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPE 118
+ R G T H A+ +GH ++ LLS+G + D +H AA GH E
Sbjct: 129 LLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGA-NINAFDKKDRRAIHWAAYMGHIE 187
Query: 119 VVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYL 178
VV L+ HG + T P+H AA+ G ++ L++ + +N G TPL++
Sbjct: 188 VVKLLVSHGA-EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVD-MNEPNAYGNTPLHV 245
Query: 179 ACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDK 238
AC G V L+ +CGA + + G TPLH AA H + + L+ ++ + K
Sbjct: 246 ACYNGQDVVVNELI-DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
Query: 239 DGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAE 297
DG T +H A G ++ G I D G TPLH AA G L+ +GA+
Sbjct: 305 DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
Query: 298 LDVRDRDGYTAADLSDFNGHSHCTRYL 324
R G L+ +G S C R L
Sbjct: 365 TAKRGIHGMFPLHLAALSGFSDCCRKL 391
Score = 110 bits (275), Expect = 6e-24
Identities = 100/325 (30%), Positives = 149/325 (45%), Gaps = 21/325 (6%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AA G L+ L L G + +D P+H+AA CL LV A R
Sbjct: 412 AAAGGNLECLNLLLNTGA-DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDER 470
Query: 69 NGATPAHDASATGHLA-CLQWLLSQGGCRVQDKDNSGATVLHLAARFGH---------PE 118
G TP H A+ + CL++LL + +D G +H +A +GH
Sbjct: 471 -GCTPLHYAATSDTDGKCLEYLL-RNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASET 528
Query: 119 VVNWLLHHGGGDPTAATDMGAL--PIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPL 176
++ L+ G D + +D A P+H AA G +L +LV+ + ++ + +G TPL
Sbjct: 529 PLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLD-LDVRNSSGRTPL 587
Query: 177 YLACQEGHLEVTQYLVQECGADPHARAHD-GMTPLHAAAQMGHSPVIVWLVSCTDV--SL 233
LA +GH+E L+ + GA + + TP+HAAA GHS + L+ + ++
Sbjct: 588 DLAAFKGHVECVDVLINQ-GASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAV 646
Query: 234 SEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILV 292
QD +G T + + GHT + LL G + A D WG T LH A G EC L+
Sbjct: 647 DIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALL 706
Query: 293 VNGAELDVRDRDGYTAADLSDFNGH 317
+GA+ +RD G T LS GH
Sbjct: 707 QHGAKCLLRDSRGRTPIHLSAACGH 731
Score = 107 bits (266), Expect = 6e-23
Identities = 107/399 (26%), Positives = 166/399 (41%), Gaps = 59/399 (14%)
Query: 39 PVHHAARA--GKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCR 96
P+H AA + G L CL LV A ++++G TP H + G + Q ++ Q G
Sbjct: 275 PLHFAAASTHGAL-CLELLVGNGA-DVNMKSKDGKTPLHMTALHGRFSRSQTII-QSGAV 331
Query: 97 VQDKDNSGATVLHLAARFGHPEVVNWLLHHG----------------------------- 127
+ +D +G T LH+AAR+GH ++N L+ G
Sbjct: 332 IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKL 391
Query: 128 ---GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGH 184
G D D G +H AAA G+ L LL+ + N + K G +PL+ A +
Sbjct: 392 LSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD-FNKKDKFGRSPLHYAAANCN 450
Query: 185 LEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAM 244
+ LV GA + G TPLH AA + + D + +DK G A+
Sbjct: 451 YQCLFALVGS-GASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAV 509
Query: 245 HFAASRGHTKVLSWLLLH----------GGEISADLWGG---TPLHDAAENGELECCQIL 291
H++A+ GH L + G ++ +D +PLH AA +G + ++L
Sbjct: 510 HYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVL 569
Query: 292 VVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL-RTVENLSVEHRVLSRDP------SAE 344
V + +LDVR+ G T DL+ F GH C L ++ V+ +L R P +
Sbjct: 570 VQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGH 629
Query: 345 LEAKQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSC 383
E + G + P V +Q N S L+ + C
Sbjct: 630 SECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDC 668
Score = 107 bits (266), Expect = 6e-23
Identities = 104/334 (31%), Positives = 139/334 (41%), Gaps = 33/334 (9%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AA G D R L ++G D +H AA G L CL L+ A + +
Sbjct: 379 AALSGFSDCCRKLLSSGF-DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA-DFNKKDK 436
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G +P H A+A + CL + L G V D D G T LH AA L
Sbjct: 437 FGRSPLHYAAANCNYQCL-FALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRND 495
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTK---------NGAT--PLY 177
+P G +HY+AA G L+L+ P V +T N AT PL+
Sbjct: 496 ANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLH 555
Query: 178 LACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQD 237
LA GH + + LVQ D R G TPL AA GH V C DV +++
Sbjct: 556 LAAYHGHHQALEVLVQSL-LDLDVRNSSGRTPLDLAAFKGH-------VECVDVLINQGA 607
Query: 238 ----KD---GATAMHFAASRGHTKVLSWLLLHGGEISA----DLWGGTPLHDAAENGELE 286
KD T +H AA+ GH++ L L+ + +A D G TPL + NG +
Sbjct: 608 SILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 667
Query: 287 CCQILVVNGAELDVRDRDGYTAADLSDFNGHSHC 320
C L+ GA +D +D+ G TA GH C
Sbjct: 668 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEEC 701
Score = 103 bits (258), Expect = 5e-22
Identities = 101/354 (28%), Positives = 133/354 (37%), Gaps = 85/354 (24%)
Query: 35 LDALPVHHAARAGKLHCLRFLVEEAALPAAARAR--NGATPAHDASATGHLACLQWLLSQ 92
L P+H AA G CLR L+ A A + NG TP + GH C+ LL++
Sbjct: 616 LKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675
Query: 93 GGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG------------------------ 128
G V KD G T LH A GH E V+ LL HG
Sbjct: 676 GA-NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGV 734
Query: 129 ------------GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHY----PEG-------- 164
+P A + G +H+A G + LL+E EG
Sbjct: 735 LGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHC 794
Query: 165 ---------------------VNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARA 203
VNA G TPL+ A H+E Q L+ A ++
Sbjct: 795 AVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSH-NAQVNSVD 853
Query: 204 HDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHT--------KV 255
G TPL AA+ G + + LVS L+ QD TA+H A S+GH K+
Sbjct: 854 STGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKI 913
Query: 256 LSWLLLHGGEISADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAA 309
L++ + TPLH AA NG Q L+ GA + D +GYT A
Sbjct: 914 TDRNLINATNAALQ----TPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPA 963
Score = 97.8 bits (242), Expect = 4e-20
Identities = 99/357 (27%), Positives = 146/357 (40%), Gaps = 48/357 (13%)
Query: 10 ARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARN 69
A + LDVL +L S + P+H AA G L LV+ + L R +
Sbjct: 525 ASETPLDVLMETSGTDMLSDS-DNRATISPLHLAAYHGHHQALEVLVQ-SLLDLDVRNSS 582
Query: 70 GATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGG 129
G TP A+ GH+ C+ L++QG + T +H AA GH E + L+ G
Sbjct: 583 GRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLI--GNA 640
Query: 130 DPTAATDM----GALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHL 185
+P A D+ G P+ + G + L+ V+A+ K G T L+ GH
Sbjct: 641 EPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHE 699
Query: 186 EVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCT---DVSLSEQDKDGAT 242
E L+Q GA R G TP+H +A GH V+ L+ D + + D G T
Sbjct: 700 ECVDALLQH-GAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYT 758
Query: 243 AMHFAASRGHTKVLSWLL---------------LHGGEIS-------------------- 267
A+H+A GH + LL LH I+
Sbjct: 759 ALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNA 818
Query: 268 ADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
D G TPLH AA +EC Q+L+ + A+++ D G T ++ NG ++ L
Sbjct: 819 TDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Score = 92.8 bits (229), Expect = 1e-18
Identities = 68/221 (30%), Positives = 112/221 (50%), Gaps = 5/221 (2%)
Query: 97 VQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRL 156
V +DN T LH AA G E++ LL G A P+H A A ++++
Sbjct: 34 VNFQDNEKRTPLHAAAYLGDAEIIE-LLILSGARVNAKDSKWLTPLHRAVASCSEEAVQV 92
Query: 157 LVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQM 216
L++H + VNA+ KN TPL++A ++ + LV ++ + G T LH AA
Sbjct: 93 LLKHSAD-VNARDKNWQTPLHIAAANKAVKCAEALVPLL-SNVNVSDRAGRTALHHAAFS 150
Query: 217 GHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTP 275
GH ++ L+S +++ DK A+H+AA GH +V+ L+ HG E++ D TP
Sbjct: 151 GHGEMVKLLLS-RGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTP 209
Query: 276 LHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNG 316
LH AA +G + + L+ G +++ + G T ++ +NG
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
Score = 90.5 bits (223), Expect = 6e-18
Identities = 79/247 (31%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Query: 72 TPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDP 131
TP H A+ G ++ LL G RV KD+ T LH A E V LL H D
Sbjct: 43 TPLHAAAYLGDAEIIE-LLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKH-SADV 100
Query: 132 TAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYL 191
A P+H AAA LV VN + G T L+ A GH E+ + L
Sbjct: 101 NARDKNWQTPLHIAAANKAVKCAEALVP-LLSNVNVSDRAGRTALHHAAFSGHGEMVKLL 159
Query: 192 VQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRG 251
+ GA+ +A +H AA MGH V+ LVS ++ +DK T +H AAS G
Sbjct: 160 LSR-GANINAFDKKDRRAIHWAAYMGHIEVVKLLVS-HGAEVTCKDKKSYTPLHAAASSG 217
Query: 252 HTKVLSWLLLHGGEIS-ADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAAD 310
V+ +LL G +++ + +G TPLH A NG+ L+ GA ++ ++ G+T
Sbjct: 218 MISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLH 277
Query: 311 LSDFNGH 317
+ + H
Sbjct: 278 FAAASTH 284
Score = 88.2 bits (217), Expect = 3e-17
Identities = 81/270 (30%), Positives = 116/270 (42%), Gaps = 10/270 (3%)
Query: 31 LRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA---RNGATPAHDASATGHLACLQ 87
LRD P+H +A G + L L++ AA A A +G T H A GH C++
Sbjct: 714 LRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVE 773
Query: 88 WLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDM-GALPIHYAA 146
LL Q Q + + + LH A + L+ G ATD G P+H AA
Sbjct: 774 LLLEQEV--FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAA 831
Query: 147 AKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDG 206
L+LL+ H + VN+ G TPL +A + G + LV A+ + +
Sbjct: 832 FTDHVECLQLLLSHNAQ-VNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK 890
Query: 207 MTPLHAAAQMGH-SPVIVWLVSCTDVSLSEQDKDG-ATAMHFAASRGHTKVLSWLLLHGG 264
T LH A GH + ++ L TD +L T +H AA G T V+ LL G
Sbjct: 891 NTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGA 950
Query: 265 EISA-DLWGGTPLHDAAENGELECCQILVV 293
+ A D G TP A N ++ C L++
Sbjct: 951 SVLAVDENGYTPALACAPNKDVADCLALIL 980
Score = 62.4 bits (150), Expect = 2e-09
Identities = 40/128 (31%), Positives = 68/128 (53%), Gaps = 2/128 (1%)
Query: 198 DPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLS 257
D + + ++ TPLHAAA +G + +I L+ + ++ +D T +H A + + +
Sbjct: 33 DVNFQDNEKRTPLHAAAYLGDAEIIELLI-LSGARVNAKDSKWLTPLHRAVASCSEEAVQ 91
Query: 258 WLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNG 316
LL H +++A D TPLH AA N ++C + LV + ++V DR G TA + F+G
Sbjct: 92 VLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSG 151
Query: 317 HSHCTRYL 324
H + L
Sbjct: 152 HGEMVKLL 159
Score = 46.6 bits (109), Expect = 1e-04
Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 236 QDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVN 294
QD + T +H AA G +++ L+L G ++A D TPLH A + E Q+L+ +
Sbjct: 37 QDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKH 96
Query: 295 GAELDVRDRDGYTAADLSDFNGHSHCTRYL-RTVENLSVEHR 335
A+++ RD++ T ++ N C L + N++V R
Sbjct: 97 SADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDR 138
>gi|50511945 cajalin 2 isoform a [Homo sapiens]
Length = 1248
Score = 110 bits (275), Expect = 6e-24
Identities = 87/287 (30%), Positives = 130/287 (45%), Gaps = 15/287 (5%)
Query: 94 GCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPS 153
G V D+SG T LH AA GH ++V LL + A + G PIH AA KGD
Sbjct: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEAST-NVADNKGYFPIHLAAWKGDVEI 107
Query: 154 LRLLVEHYPEG--VNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLH 211
+++L+ H P VN Q T L+ A Q GH EV L++E DP R TPL
Sbjct: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEEL-TDPTIRNSKLETPLD 166
Query: 212 AAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLW 271
AA G V+ ++S +S + T +H AA GH V+ LL G ++S
Sbjct: 167 LAALYGRLRVVKMIISAHPNLMSCNTRKH-TPLHLAARNGHKAVVQVLLEAGMDVSCQTE 225
Query: 272 GGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADL-------SDFNGHSHCTRYL 324
G+ LH+AA G+++ ++L+ G + +++D G T D+ + YL
Sbjct: 226 KGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYL 285
Query: 325 RTVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLNFDLS 371
V +V + D + E P + SP+ + + +LS
Sbjct: 286 EGVGRSTVLEEPVQEDATQETHISSP---VESPSQKTKSETVTGELS 329
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/179 (29%), Positives = 78/179 (43%), Gaps = 7/179 (3%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AA+ G +V+ L L P++R+ P+ AA G+L ++ ++ + R
Sbjct: 135 AAQYGHSEVVAVL-LEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTR 193
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
TP H A+ GH A +Q LL + G V + G + LH AA FG +VV LL G
Sbjct: 194 KH-TPLHLAARNGHKAVVQVLL-EAGMDVSCQTEKG-SALHEAALFGKVDVVRVLL-ETG 249
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRL--LVEHYPEGVNAQTKNGATPLYLACQEGHL 185
D +G + SL++ L++ Y EGV T A QE H+
Sbjct: 250 IDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQETHI 308
Score = 43.9 bits (102), Expect = 6e-04
Identities = 37/138 (26%), Positives = 61/138 (44%), Gaps = 5/138 (3%)
Query: 183 GHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGAT 242
G L ++ L G + + G T LH AA GH +++ L+ + S + D G
Sbjct: 36 GPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQ-YEASTNVADNKGYF 94
Query: 243 AMHFAASRGHTKVLSWLLLHGGEIS----ADLWGGTPLHDAAENGELECCQILVVNGAEL 298
+H AA +G +++ L+ HG S + T LH AA+ G E +L+ +
Sbjct: 95 PIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDP 154
Query: 299 DVRDRDGYTAADLSDFNG 316
+R+ T DL+ G
Sbjct: 155 TIRNSKLETPLDLAALYG 172
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 109 bits (272), Expect = 1e-23
Identities = 90/329 (27%), Positives = 144/329 (43%), Gaps = 46/329 (13%)
Query: 38 LPVHHAAR---AGKLHCLRFLVEEAALPAAARARN--GATPAHDASATGHLACLQWLLSQ 92
+P+H AA +H +R +++ A + ++ G TP H A A G++ + L S
Sbjct: 184 IPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY 243
Query: 93 GGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFP 152
C + DN T LH AA GH ++V+ LL + GA P+HYAA
Sbjct: 244 ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAE 303
Query: 153 SLRLLVEHYP-------EG---------------------------VNAQTKNGATPLYL 178
++++ ++H EG +N K G T L+
Sbjct: 304 TVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHA 363
Query: 179 ACQEGHLEVTQYLVQECGADPHARAHDGM--TPLHAAAQMGHSPVIVWLVSCTDVSLSEQ 236
A GH+ + L++ + A D M TPL A +MGH VI L+ +
Sbjct: 364 AALSGHVSTVKLLLEN---NAQVDATDVMKHTPLFRACEMGHKDVIQTLIK-GGARVDLV 419
Query: 237 DKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNG 295
D+DG + +H+AA G+ V L+ + + D G TPL AA G + C +L+ N
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENN 479
Query: 296 AELDVRDRDGYTAADLSDFNGHSHCTRYL 324
A+ +++D++G TA S NG+ + L
Sbjct: 480 ADPNIQDKEGRTALHWSCNNGYLDAIKLL 508
Score = 83.6 bits (205), Expect = 7e-16
Identities = 79/280 (28%), Positives = 126/280 (45%), Gaps = 9/280 (3%)
Query: 15 LDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPA 74
+DVL S + + D L P+H AA G + L+E GATP
Sbjct: 237 VDVLTSYESCNITS---YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPL 293
Query: 75 HDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLH-HGGGDPTA 133
H A+ + ++ L + D D G T AA G +V+ +L D
Sbjct: 294 HYAAQSNFAETVKVFLKHPSVK-DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINM 352
Query: 134 ATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQ 193
A G +H AA G +++LL+E+ + V+A TPL+ AC+ GH +V Q L++
Sbjct: 353 ADKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIK 411
Query: 194 ECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHT 253
GA DG + LH AA G++ V L+ ++ + QD G T + AA G+
Sbjct: 412 G-GARVDLVDQDGHSLLHWAALGGNADVCQILIE-NKINPNVQDYAGRTPLQCAAYGGYI 469
Query: 254 KVLSWLLLHGGEIS-ADLWGGTPLHDAAENGELECCQILV 292
++ L+ + + + D G T LH + NG L+ ++L+
Sbjct: 470 NCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 68.6 bits (166), Expect = 2e-11
Identities = 80/314 (25%), Positives = 124/314 (39%), Gaps = 45/314 (14%)
Query: 37 ALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCR 96
A VH AA G L+ L+ + + G TP L C LL + G
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALL-KAGAD 73
Query: 97 VQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGAL-PIHYAAAKGDFPSLR 155
V D+S T LHLAA+ G+ + LL D+ + P+H L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN--WMQKDLEEMTPLHLTTRHRSPKCLA 131
Query: 156 LLVEHYPEG-VNAQTKNGATPLYLACQEGHLEVTQYLVQECG------------------ 196
LL++ G V+ Q KN T L+ + + E + L++
Sbjct: 132 LLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAAN 191
Query: 197 -ADPHA-------------------RAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQ 236
DP A + ++G TPLH A G+ V+ L S +++
Sbjct: 192 HKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSY 251
Query: 237 DKDGATAMHFAASRGHTKVLSWLLLH--GGEISADLWGGTPLHDAAENGELECCQILVVN 294
D T +H+AA GH +++ LL G I +D G TPLH AA++ E ++ + +
Sbjct: 252 DNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 295 GAELDVRDRDGYTA 308
+ D D +G T+
Sbjct: 312 PSVKDDSDLEGRTS 325
Score = 32.0 bits (71), Expect = 2.5
Identities = 24/88 (27%), Positives = 38/88 (43%), Gaps = 2/88 (2%)
Query: 241 ATAMHFAASRGHTKVLSWLLLHGGEIS--ADLWGGTPLHDAAENGELECCQILVVNGAEL 298
A+ +H AA G L L++ + D +G TPL L+C L+ GA++
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADV 74
Query: 299 DVRDRDGYTAADLSDFNGHSHCTRYLRT 326
+ D TA L+ G+ + L T
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLT 102
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 109 bits (272), Expect = 1e-23
Identities = 90/329 (27%), Positives = 144/329 (43%), Gaps = 46/329 (13%)
Query: 38 LPVHHAAR---AGKLHCLRFLVEEAALPAAARARN--GATPAHDASATGHLACLQWLLSQ 92
+P+H AA +H +R +++ A + ++ G TP H A A G++ + L S
Sbjct: 184 IPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY 243
Query: 93 GGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFP 152
C + DN T LH AA GH ++V+ LL + GA P+HYAA
Sbjct: 244 ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAE 303
Query: 153 SLRLLVEHYP-------EG---------------------------VNAQTKNGATPLYL 178
++++ ++H EG +N K G T L+
Sbjct: 304 TVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHA 363
Query: 179 ACQEGHLEVTQYLVQECGADPHARAHDGM--TPLHAAAQMGHSPVIVWLVSCTDVSLSEQ 236
A GH+ + L++ + A D M TPL A +MGH VI L+ +
Sbjct: 364 AALSGHVSTVKLLLEN---NAQVDATDVMKHTPLFRACEMGHKDVIQTLIK-GGARVDLV 419
Query: 237 DKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNG 295
D+DG + +H+AA G+ V L+ + + D G TPL AA G + C +L+ N
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENN 479
Query: 296 AELDVRDRDGYTAADLSDFNGHSHCTRYL 324
A+ +++D++G TA S NG+ + L
Sbjct: 480 ADPNIQDKEGRTALHWSCNNGYLDAIKLL 508
Score = 83.6 bits (205), Expect = 7e-16
Identities = 79/280 (28%), Positives = 126/280 (45%), Gaps = 9/280 (3%)
Query: 15 LDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPA 74
+DVL S + + D L P+H AA G + L+E GATP
Sbjct: 237 VDVLTSYESCNITS---YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPL 293
Query: 75 HDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLH-HGGGDPTA 133
H A+ + ++ L + D D G T AA G +V+ +L D
Sbjct: 294 HYAAQSNFAETVKVFLKHPSVK-DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINM 352
Query: 134 ATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQ 193
A G +H AA G +++LL+E+ + V+A TPL+ AC+ GH +V Q L++
Sbjct: 353 ADKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIK 411
Query: 194 ECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHT 253
GA DG + LH AA G++ V L+ ++ + QD G T + AA G+
Sbjct: 412 G-GARVDLVDQDGHSLLHWAALGGNADVCQILIE-NKINPNVQDYAGRTPLQCAAYGGYI 469
Query: 254 KVLSWLLLHGGEIS-ADLWGGTPLHDAAENGELECCQILV 292
++ L+ + + + D G T LH + NG L+ ++L+
Sbjct: 470 NCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 68.6 bits (166), Expect = 2e-11
Identities = 80/314 (25%), Positives = 124/314 (39%), Gaps = 45/314 (14%)
Query: 37 ALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCR 96
A VH AA G L+ L+ + + G TP L C LL + G
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALL-KAGAD 73
Query: 97 VQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGAL-PIHYAAAKGDFPSLR 155
V D+S T LHLAA+ G+ + LL D+ + P+H L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN--WMQKDLEEMTPLHLTTRHRSPKCLA 131
Query: 156 LLVEHYPEG-VNAQTKNGATPLYLACQEGHLEVTQYLVQECG------------------ 196
LL++ G V+ Q KN T L+ + + E + L++
Sbjct: 132 LLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAAN 191
Query: 197 -ADPHA-------------------RAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQ 236
DP A + ++G TPLH A G+ V+ L S +++
Sbjct: 192 HKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSY 251
Query: 237 DKDGATAMHFAASRGHTKVLSWLLLH--GGEISADLWGGTPLHDAAENGELECCQILVVN 294
D T +H+AA GH +++ LL G I +D G TPLH AA++ E ++ + +
Sbjct: 252 DNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 295 GAELDVRDRDGYTA 308
+ D D +G T+
Sbjct: 312 PSVKDDSDLEGRTS 325
Score = 32.0 bits (71), Expect = 2.5
Identities = 24/88 (27%), Positives = 38/88 (43%), Gaps = 2/88 (2%)
Query: 241 ATAMHFAASRGHTKVLSWLLLHGGEIS--ADLWGGTPLHDAAENGELECCQILVVNGAEL 298
A+ +H AA G L L++ + D +G TPL L+C L+ GA++
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADV 74
Query: 299 DVRDRDGYTAADLSDFNGHSHCTRYLRT 326
+ D TA L+ G+ + L T
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLT 102
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 108 bits (271), Expect = 2e-23
Identities = 88/287 (30%), Positives = 140/287 (48%), Gaps = 10/287 (3%)
Query: 43 AARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDN 102
AAR G L L+ L+ + R +G T A+ GH+ C++ L+ QG + +
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGA-DINLQRE 77
Query: 103 SGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYP 162
SG T L AA+ GH +VV +L G D G + A+ G + L++H
Sbjct: 78 SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKD-GGTALLAASQYGHMQVVETLLKH-G 135
Query: 163 EGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVI 222
++ Q +GAT L+LA Q G+L+V + L+ GA + DG PL A+QMGHS V+
Sbjct: 136 ANIHDQLYDGATALFLAAQGGYLDVIRLLLAS-GAKVNQPRQDGTAPLWIASQMGHSEVV 194
Query: 223 -VWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGGTPLHDAAE 281
V L+ D + D G TA+ AA++G+ V+ LL + G + LH A
Sbjct: 195 RVMLLRGADRDAARND--GTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVL 252
Query: 282 NGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVE 328
+G ++ +L+ GA+ +R++ A+L+ + R LR+ E
Sbjct: 253 SGNIKTVALLLEAGADPSLRNKANELPAELTK---NERILRLLRSKE 296
Score = 96.3 bits (238), Expect = 1e-19
Identities = 74/239 (30%), Positives = 112/239 (46%), Gaps = 38/239 (15%)
Query: 71 ATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGD 130
A A A+ G+LA L+ LL+ G V +D+ G T+L +AA GH + V L+ G
Sbjct: 13 ANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGA-- 70
Query: 131 PTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQY 190
+N Q ++G T L+ A Q+GH +V ++
Sbjct: 71 ---------------------------------DINLQRESGTTALFFAAQQGHNDVVRF 97
Query: 191 LVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASR 250
L GA R DG T L AA+Q GH V+ L+ ++ +Q DGATA+ AA
Sbjct: 98 LF-GFGASTEFRTKDGGTALLAASQYGHMQVVETLLK-HGANIHDQLYDGATALFLAAQG 155
Query: 251 GHTKVLSWLLLHGGEISADLWGGT-PLHDAAENGELECCQILVVNGAELDVRDRDGYTA 308
G+ V+ LL G +++ GT PL A++ G E +++++ GA+ D DG TA
Sbjct: 156 GYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTA 214
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 4/87 (4%)
Query: 241 ATAMHFAASRGHTKVLSWLLLHGGEISADL---WGGTPLHDAAENGELECCQILVVNGAE 297
A A +AA RG+ +L LLL+ G + D G T L AA G ++C + LV+ GA+
Sbjct: 13 ANAAFWAARRGNLALLK-LLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGAD 71
Query: 298 LDVRDRDGYTAADLSDFNGHSHCTRYL 324
++++ G TA + GH+ R+L
Sbjct: 72 INLQRESGTTALFFAAQQGHNDVVRFL 98
Score = 32.3 bits (72), Expect = 1.9
Identities = 40/133 (30%), Positives = 59/133 (44%), Gaps = 5/133 (3%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AA+ G LDV+R L A+G R A P+ A++ G +R ++ A AAR
Sbjct: 152 AAQGGYLDVIRLLLASGAKVNQPRQDGTA-PLWIASQMGHSEVVRVMLLRGADRDAAR-N 209
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
+G T A+ G+ ++ LL K +G + LH A G+ + V LL G
Sbjct: 210 DGTTALLKAANKGYNDVIKELLKFSPTLGILK--NGTSALHAAVLSGNIKTVALLL-EAG 266
Query: 129 GDPTAATDMGALP 141
DP+ LP
Sbjct: 267 ADPSLRNKANELP 279
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 106 bits (265), Expect = 8e-23
Identities = 104/362 (28%), Positives = 166/362 (45%), Gaps = 31/362 (8%)
Query: 32 RDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLS 91
RD P+ AA AG + + L++ A A R TP A + G ++ LL+
Sbjct: 1112 RDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLA 1171
Query: 92 QGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGG-DPTAATDMGALPIHYAAAKGD 150
+G + + ++ S T L LAA G+ ++ LL+ G + + +G P+ AA G
Sbjct: 1172 RGANK-EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1230
Query: 151 FPSLRLLVEHYPEGVNAQTK-NGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTP 209
+++LL++ + +NAQ + N T L LAC +G EV L+ H RA G+TP
Sbjct: 1231 TAAVKLLLDMGSD-INAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEH-RAKTGLTP 1288
Query: 210 LHAAAQMGHSPV-IVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA 268
L AA G++ V V L DV+ TA+ AA +GH K L+ G I
Sbjct: 1289 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDV 1348
Query: 269 -DLWGGTPLHDAAENGELECCQILVVNGAELDVRD-----------RDG------YTAAD 310
+ G TPL AA G L+ Q+LV GA++D D R G Y +
Sbjct: 1349 RNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
Query: 311 LSDFNGHSHCTRYLRTV---ENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLN 367
++ F S C RY+ T+ E L H + + ++AK + ++ N ++ ++ L+
Sbjct: 1409 VNQFPSDSECMRYIATITDKEMLKKCHLCM----ESIVQAKDRQAAEANKNASILLEELD 1464
Query: 368 FD 369
+
Sbjct: 1465 LE 1466
Score = 97.8 bits (242), Expect = 4e-20
Identities = 105/413 (25%), Positives = 169/413 (40%), Gaps = 19/413 (4%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
A +G L+++R L AG D + + A G + R L++ A A
Sbjct: 408 ACYKGHLEMVRFLLEAGADQEHKTDEMHTA-LMEACMDGHVEVARLLLDSGA-QVNMPAD 465
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
+ +P A+ GH+ L LL + G +++ ++ G T L AAR GH E+V LL G
Sbjct: 466 SFESPLTLAACGGHVE-LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNG-ATPLYLACQEGHLEV 187
+ + A G L++ A + G +TPL A QEGHLE+
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIK-----AGADIELGCSTPLMEAAQEGHLEL 579
Query: 188 TQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFA 247
+YL+ GA+ HA G T L A + GH+ V L+ L + + G T + A
Sbjct: 580 VKYLLA-AGANVHATTATGDTALTYACENGHTDVADVLLQA-GADLEHESEGGRTPLMKA 637
Query: 248 ASRGHTKVLSWLLLHGGEISADLWGG--TPLHDAAENGELECCQILVVNGAELDVRDRDG 305
A GH + +L+ G ++ T L A G L ++L+ +GA+ R +DG
Sbjct: 638 ARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDG 697
Query: 306 YTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDSGMS-SPNTTVSVQ 364
T + GH+ YL L + +LS P + P ++ +P V
Sbjct: 698 STMLIEAAKGGHTSVVCYL-----LDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQAL 752
Query: 365 PLNFDLSSPTSTLSNYDSCSSSHSSIKGQHPPCGLSSARAADIQSYMDMLNPE 417
P+ P +N + + + A + D+Q Y+ +PE
Sbjct: 753 PMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHLPANSQDVQGYITNQSPE 805
Score = 96.7 bits (239), Expect = 8e-20
Identities = 88/315 (27%), Positives = 138/315 (43%), Gaps = 37/315 (11%)
Query: 36 DALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGC 95
D P+ AA G + ++ L+ A A++ G T A A G++ ++ LL + G
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKA-DVNAQSSTGNTALTYACAGGYVDVVKVLL-ESGA 358
Query: 96 RVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLR 155
++D + +G T L A GH EV LL +G G T + + + A KG +R
Sbjct: 359 SIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVR 418
Query: 156 LLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQ 215
L+E + + +T T L AC +GH+EV + L+ + GA + A +PL AA
Sbjct: 419 FLLEAGADQEH-KTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAAC 476
Query: 216 MGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA------- 268
GH + L+ SL E + +G T + AA GH ++++ LL G I+A
Sbjct: 477 GGHVELAALLIE-RGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQE 535
Query: 269 -------------------------DLWGGTPLHDAAENGELECCQILVVNGAELDVRDR 303
+L TPL +AA+ G LE + L+ GA +
Sbjct: 536 TALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTA 595
Query: 304 DGYTAADLSDFNGHS 318
G TA + NGH+
Sbjct: 596 TGDTALTYACENGHT 610
Score = 84.0 bits (206), Expect = 6e-16
Identities = 117/466 (25%), Positives = 175/466 (37%), Gaps = 66/466 (14%)
Query: 42 HAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKD 101
+A G + ++ L+E A NG TP +A + GH+ + LL G +
Sbjct: 340 YACAGGYVDVVKVLLESGA-SIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN 398
Query: 102 NSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHY 161
+ L LA GH E+V +LL G D TD + A G RLL++
Sbjct: 399 EFKESALTLACYKGHLEMVRFLLE-AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 457
Query: 162 PEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPV 221
+ VN + +PL LA GH+E+ L++ GA +G TPL AA+ GH +
Sbjct: 458 AQ-VNMPADSFESPLTLAACGGHVELAALLIER-GASLEEVNDEGYTPLMEAAREGHEEM 515
Query: 222 IVWLV--------------------SCTDVSLSEQD---KDGA-------TAMHFAASRG 251
+ L+ +C L D K GA T + AA G
Sbjct: 516 VALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEG 575
Query: 252 HTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAAD 310
H +++ +LL G + A G T L A ENG + +L+ GA+L+ G T
Sbjct: 576 HLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLM 635
Query: 311 LSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLNFDL 370
+ GH CT + +V + D + S + V+ L
Sbjct: 636 KAARAGHV-CTVQFLISKGANVNRTTANNDHTVL-------SLACAGGHLAVVELLLAHG 687
Query: 371 SSPTSTLSNYDSCSSSHSSIKGQHPPCGLSSARAADIQSYMDMLNPELGLPRGTIGKPTP 430
+ PT L D + + KG H + + +D N L P + + TP
Sbjct: 688 ADPTHRLK--DGSTMLIEAAKGGH---------TSVVCYLLDYPNNLLSAPPPDVTQLTP 736
Query: 431 PP---------PPPSFPPPPPPPGTQLPPPPPGYPAPKPPVGPQAA 467
P P + P PP Q P PP A P+ +AA
Sbjct: 737 PSHDLNRAPRVPVQALPMVVPP---QEPDKPPANVATTLPIRNKAA 779
Score = 80.1 bits (196), Expect = 8e-15
Identities = 70/234 (29%), Positives = 106/234 (45%), Gaps = 9/234 (3%)
Query: 7 LQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAAR 66
++AAR+G +++ L G + + + A G L FL++ A A
Sbjct: 505 MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK-----AGAD 559
Query: 67 ARNG-ATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLH 125
G +TP +A+ GHL +++LL+ G V +G T L A GH +V + LL
Sbjct: 560 IELGCSTPLMEAAQEGHLELVKYLLA-AGANVHATTATGDTALTYACENGHTDVADVLLQ 618
Query: 126 HGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHL 185
G D ++ G P+ AA G +++ L+ N T L LAC GHL
Sbjct: 619 -AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677
Query: 186 EVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKD 239
V + L+ GADP R DG T L AA+ GH+ V+ +L+ + LS D
Sbjct: 678 AVVELLLAH-GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPD 730
Score = 79.0 bits (193), Expect = 2e-14
Identities = 79/281 (28%), Positives = 125/281 (44%), Gaps = 45/281 (16%)
Query: 77 ASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATD 136
A A GH +Q LL +G ++ +D G T L LAA GH VV LL +G +
Sbjct: 1090 ACAGGHEELVQTLLERGAS-IEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 1148
Query: 137 MGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGA--TPLYLACQEGHLEVTQYLVQE 194
P+ A + G + LL+ G N + +N + TPL LA G++ + + L+
Sbjct: 1149 TKDTPLSLACSGGRQEVVELLL---ARGANKEHRNVSDYTPLSLAASGGYVNIIKILL-N 1204
Query: 195 CGADPHARAHD--GMTPLHAAAQMGHSPVIVWLVSC------------------------ 228
GA+ ++R G++PL AA GH+ + L+
Sbjct: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264
Query: 229 TDV---------SLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA---DLWGGTPL 276
T+V ++ + K G T + AAS G+ +V LL G +++A T L
Sbjct: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1324
Query: 277 HDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGH 317
AA+ G + C++L+ GA +DVR++ G T L+ GH
Sbjct: 1325 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGH 1365
Score = 72.0 bits (175), Expect = 2e-12
Identities = 72/252 (28%), Positives = 114/252 (45%), Gaps = 10/252 (3%)
Query: 77 ASATGHLACLQWLLSQGGCRVQDKDNSG-ATVLHLAARFGHPEVVNWLLHHGGGDPTAAT 135
A + G+ Q LL+ V+D+ G T L AA GH ++V LL H D A +
Sbjct: 274 ACSAGYYELAQVLLAMHA-NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKA-DVNAQS 331
Query: 136 DMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQE- 194
G + YA A G +++L+E + +NG TPL A GH+EV + L++
Sbjct: 332 STGNTALTYACAGGYVDVVKVLLES-GASIEDHNENGHTPLMEAGSAGHVEVARLLLENG 390
Query: 195 CGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTK 254
G + H+ + L A GH ++ +L+ + + TA+ A GH +
Sbjct: 391 AGINTHSNEFKE-SALTLACYKGHLEMVRFLLEA-GADQEHKTDEMHTALMEACMDGHVE 448
Query: 255 VLSWLLLHGGEIS--ADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLS 312
V LL G +++ AD + +PL AA G +E +L+ GA L+ + +GYT +
Sbjct: 449 VARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507
Query: 313 DFNGHSHCTRYL 324
GH L
Sbjct: 508 AREGHEEMVALL 519
Score = 65.1 bits (157), Expect = 3e-10
Identities = 68/207 (32%), Positives = 99/207 (47%), Gaps = 19/207 (9%)
Query: 134 ATDMGALPIHYAAAKGDFP---------SLRLLVEHYPE-GVNAQTK-NGATPLYLACQE 182
A+ M P H AA P S ++ YP ++AQT+ N T L LAC
Sbjct: 1034 ASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAG 1093
Query: 183 GHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVI-VWLVSCTDV-SLSEQDKDG 240
GH E+ Q L++ GA R G TPL AA GH V+ + L + D+ + SE+ KD
Sbjct: 1094 GHEELVQTLLER-GASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD- 1151
Query: 241 ATAMHFAASRGHTKVLSWLLLHG-GEISADLWGGTPLHDAAENGELECCQILVVNGAELD 299
T + A S G +V+ LL G + ++ TPL AA G + +IL+ GAE++
Sbjct: 1152 -TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1210
Query: 300 VR--DRDGYTAADLSDFNGHSHCTRYL 324
R + G + L+ NGH+ + L
Sbjct: 1211 SRTGSKLGISPLMLAAMNGHTAAVKLL 1237
Score = 56.6 bits (135), Expect = 9e-08
Identities = 49/192 (25%), Positives = 92/192 (47%), Gaps = 4/192 (2%)
Query: 135 TDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQE 194
T+ G + A + G + ++L+ + + K TPL A GH+++ + L+
Sbjct: 264 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323
Query: 195 CGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTK 254
AD +A++ G T L A G+ V+ L+ + S+ + +++G T + A S GH +
Sbjct: 324 -KADVNAQSSTGNTALTYACAGGYVDVVKVLLE-SGASIEDHNENGHTPLMEAGSAGHVE 381
Query: 255 VLSWLLLHGGEIS--ADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLS 312
V LL +G I+ ++ + + L A G LE + L+ GA+ + + + +TA +
Sbjct: 382 VARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEA 441
Query: 313 DFNGHSHCTRYL 324
+GH R L
Sbjct: 442 CMDGHVEVARLL 453
Score = 42.0 bits (97), Expect = 0.002
Identities = 38/162 (23%), Positives = 68/162 (41%), Gaps = 11/162 (6%)
Query: 667 PTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSLVPVPPT 726
P P LT + + P LP V P P + P A P+ N + +
Sbjct: 727 PPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTL-PIRNKAASKQKSS 785
Query: 727 TPAPGVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEEEEARLASM 786
+ P DV+ I + +V + Q K+ E E++ ++ E+ A+L S+
Sbjct: 786 SHLPANSQDVQGYITNQSPES----------IVEEAQGKLTELEQRIKEAIEKNAQLQSL 835
Query: 787 PAWRRDLLRKKLEEEREQKRKEEERQKQEELRREKEQSEKLR 828
D L K+ EE + R+E+ ++KQ+ L ++ +L+
Sbjct: 836 ELAHADQLTKEKIEELNKTREEQIQKKQKILEELQKVERELQ 877
Score = 36.6 bits (83), Expect = 0.10
Identities = 33/130 (25%), Positives = 52/130 (40%), Gaps = 8/130 (6%)
Query: 337 LSRDPSAELEAKQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQHPP 396
+SR+ + + P+ SS P+ ++ S+ SS+HS+ Q PP
Sbjct: 2055 VSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSN--QQQPP 2112
Query: 397 CGLSSARAADIQSYMDMLNPELGL---PRGTIGKPT--PPPPPPSFPPPPPPPGTQLPPP 451
+S +Q + PE+ + P T P P P ++P P P G P P
Sbjct: 2113 GSVSQEPRPPLQQ-SQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTP 2171
Query: 452 PPGYPAPKPP 461
PA +PP
Sbjct: 2172 KMETPAIRPP 2181
Score = 33.9 bits (76), Expect = 0.66
Identities = 17/69 (24%), Positives = 37/69 (53%)
Query: 760 RKMQLKMQEEEEQRRKEEEEEARLASMPAWRRDLLRKKLEEEREQKRKEEERQKQEELRR 819
+ + ++E + ++ +EE LA+ R++ RKK EE+R + + E + K+ +
Sbjct: 1454 KNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQ 1513
Query: 820 EKEQSEKLR 828
++ EKL+
Sbjct: 1514 AAQEKEKLK 1522
Score = 33.5 bits (75), Expect = 0.86
Identities = 35/143 (24%), Positives = 52/143 (36%), Gaps = 27/143 (18%)
Query: 341 PSAELEAKQPDSGMSSPNTTVSV------QPLNFDLSSPTSTLSNYDSCSSSHSSIK--G 392
P + P S SSP+ PL+ +SP S+ + + S ++
Sbjct: 2030 PMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTN 2089
Query: 393 QHPPCGLSSARAADIQSYMDMLNPELGLPRGTIGKPTPPPPPPSFPPPP------PPPGT 446
PP SS+ ++ S P G++ + PP S PPP PP T
Sbjct: 2090 TRPPNSSSSSGSSSAHSNQQQ-------PPGSVSQEPRPPLQQSQVPPPEVRMTVPPLAT 2142
Query: 447 QLPP------PPPGYPAPKPPVG 463
P P YP P+ P+G
Sbjct: 2143 SSAPVAVPSTAPVTYPMPQTPMG 2165
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 106 bits (265), Expect = 8e-23
Identities = 104/362 (28%), Positives = 166/362 (45%), Gaps = 31/362 (8%)
Query: 32 RDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLS 91
RD P+ AA AG + + L++ A A R TP A + G ++ LL+
Sbjct: 861 RDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLA 920
Query: 92 QGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGG-DPTAATDMGALPIHYAAAKGD 150
+G + + ++ S T L LAA G+ ++ LL+ G + + +G P+ AA G
Sbjct: 921 RGANK-EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 979
Query: 151 FPSLRLLVEHYPEGVNAQTK-NGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTP 209
+++LL++ + +NAQ + N T L LAC +G EV L+ H RA G+TP
Sbjct: 980 TAAVKLLLDMGSD-INAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEH-RAKTGLTP 1037
Query: 210 LHAAAQMGHSPV-IVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA 268
L AA G++ V V L DV+ TA+ AA +GH K L+ G I
Sbjct: 1038 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDV 1097
Query: 269 -DLWGGTPLHDAAENGELECCQILVVNGAELDVRD-----------RDG------YTAAD 310
+ G TPL AA G L+ Q+LV GA++D D R G Y +
Sbjct: 1098 RNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
Query: 311 LSDFNGHSHCTRYLRTV---ENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLN 367
++ F S C RY+ T+ E L H + + ++AK + ++ N ++ ++ L+
Sbjct: 1158 VNQFPSDSECMRYIATITDKEMLKKCHLCM----ESIVQAKDRQAAEANKNASILLEELD 1213
Query: 368 FD 369
+
Sbjct: 1214 LE 1215
Score = 96.7 bits (239), Expect = 8e-20
Identities = 88/315 (27%), Positives = 138/315 (43%), Gaps = 37/315 (11%)
Query: 36 DALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGC 95
D P+ AA G + ++ L+ A A++ G T A A G++ ++ LL + G
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKA-DVNAQSSTGNTALTYACAGGYVDVVKVLL-ESGA 358
Query: 96 RVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLR 155
++D + +G T L A GH EV LL +G G T + + + A KG +R
Sbjct: 359 SIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVR 418
Query: 156 LLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQ 215
L+E + + +T T L AC +GH+EV + L+ + GA + A +PL AA
Sbjct: 419 FLLEAGADQEH-KTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAAC 476
Query: 216 MGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA------- 268
GH + L+ SL E + +G T + AA GH ++++ LL G I+A
Sbjct: 477 GGHVELAALLIE-RGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQE 535
Query: 269 -------------------------DLWGGTPLHDAAENGELECCQILVVNGAELDVRDR 303
+L TPL +AA+ G LE + L+ GA +
Sbjct: 536 TALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTA 595
Query: 304 DGYTAADLSDFNGHS 318
G TA + NGH+
Sbjct: 596 TGDTALTYACENGHT 610
Score = 93.2 bits (230), Expect = 9e-19
Identities = 108/409 (26%), Positives = 173/409 (42%), Gaps = 34/409 (8%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
A +G L+++R L AG D + + A G + R L++ A A
Sbjct: 408 ACYKGHLEMVRFLLEAGADQEHKTDEMHTA-LMEACMDGHVEVARLLLDSGA-QVNMPAD 465
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
+ +P A+ GH+ L LL + G +++ ++ G T L AAR GH E+V LL G
Sbjct: 466 SFESPLTLAACGGHVE-LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNG-ATPLYLACQEGHLEV 187
+ + A G L++ A + G +TPL A QEGHLE+
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIK-----AGADIELGCSTPLMEAAQEGHLEL 579
Query: 188 TQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFA 247
+YL+ GA+ HA G T L A + GH+ V L+ L + + G T + A
Sbjct: 580 VKYLLA-AGANVHATTATGDTALTYACENGHTDVADVLLQA-GADLEHESEGGRTPLMKA 637
Query: 248 ASRGHTKVLSWLLLHGGEISADLWGG--TPLHDAAENGELECCQILVVNGAELDVRDRDG 305
A GH + +L+ G ++ T L A G L ++L+ +GA+ R +DG
Sbjct: 638 ARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDG 697
Query: 306 YTAADLSDFNGHSHCTRYLRTVEN------------LSVEHRVLSRDPSAELEA------ 347
T + GH+ YL N L+ L+R P ++A
Sbjct: 698 STMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP 757
Query: 348 -KQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQHP 395
++PD ++ TT+ ++ N +S S +SN + S + S + Q P
Sbjct: 758 PQEPDKPPANVATTLPIR--NKAVSGRASAMSNTPTHSIAASISQPQTP 804
Score = 82.8 bits (203), Expect = 1e-15
Identities = 92/336 (27%), Positives = 136/336 (40%), Gaps = 45/336 (13%)
Query: 42 HAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKD 101
+A G + ++ L+E A NG TP +A + GH+ + LL G +
Sbjct: 340 YACAGGYVDVVKVLLESGA-SIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN 398
Query: 102 NSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHY 161
+ L LA GH E+V +LL G D TD + A G RLL++
Sbjct: 399 EFKESALTLACYKGHLEMVRFLLE-AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 457
Query: 162 PEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPV 221
+ VN + +PL LA GH+E+ L++ GA +G TPL AA+ GH +
Sbjct: 458 AQ-VNMPADSFESPLTLAACGGHVELAALLIER-GASLEEVNDEGYTPLMEAAREGHEEM 515
Query: 222 IVWLV--------------------SCTDVSLSEQD---KDGA-------TAMHFAASRG 251
+ L+ +C L D K GA T + AA G
Sbjct: 516 VALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEG 575
Query: 252 HTKVLSWLLLHGGEISADL-WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAAD 310
H +++ +LL G + A G T L A ENG + +L+ GA+L+ G T
Sbjct: 576 HLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLM 635
Query: 311 LSDFNGHSHCTRYL--------RTVENLSVEHRVLS 338
+ GH ++L RT N +H VLS
Sbjct: 636 KAARAGHVCTVQFLISKGANVNRTTAN--NDHTVLS 669
Score = 80.1 bits (196), Expect = 8e-15
Identities = 70/234 (29%), Positives = 106/234 (45%), Gaps = 9/234 (3%)
Query: 7 LQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAAR 66
++AAR+G +++ L G + + + A G L FL++ A A
Sbjct: 505 MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK-----AGAD 559
Query: 67 ARNG-ATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLH 125
G +TP +A+ GHL +++LL+ G V +G T L A GH +V + LL
Sbjct: 560 IELGCSTPLMEAAQEGHLELVKYLLA-AGANVHATTATGDTALTYACENGHTDVADVLLQ 618
Query: 126 HGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHL 185
G D ++ G P+ AA G +++ L+ N T L LAC GHL
Sbjct: 619 -AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677
Query: 186 EVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKD 239
V + L+ GADP R DG T L AA+ GH+ V+ +L+ + LS D
Sbjct: 678 AVVELLLAH-GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPD 730
Score = 79.0 bits (193), Expect = 2e-14
Identities = 79/281 (28%), Positives = 125/281 (44%), Gaps = 45/281 (16%)
Query: 77 ASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATD 136
A A GH +Q LL +G ++ +D G T L LAA GH VV LL +G +
Sbjct: 839 ACAGGHEELVQTLLERGAS-IEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 897
Query: 137 MGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGA--TPLYLACQEGHLEVTQYLVQE 194
P+ A + G + LL+ G N + +N + TPL LA G++ + + L+
Sbjct: 898 TKDTPLSLACSGGRQEVVELLL---ARGANKEHRNVSDYTPLSLAASGGYVNIIKILL-N 953
Query: 195 CGADPHARAHD--GMTPLHAAAQMGHSPVIVWLVSC------------------------ 228
GA+ ++R G++PL AA GH+ + L+
Sbjct: 954 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1013
Query: 229 TDV---------SLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA---DLWGGTPL 276
T+V ++ + K G T + AAS G+ +V LL G +++A T L
Sbjct: 1014 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1073
Query: 277 HDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGH 317
AA+ G + C++L+ GA +DVR++ G T L+ GH
Sbjct: 1074 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGH 1114
Score = 72.0 bits (175), Expect = 2e-12
Identities = 72/252 (28%), Positives = 114/252 (45%), Gaps = 10/252 (3%)
Query: 77 ASATGHLACLQWLLSQGGCRVQDKDNSG-ATVLHLAARFGHPEVVNWLLHHGGGDPTAAT 135
A + G+ Q LL+ V+D+ G T L AA GH ++V LL H D A +
Sbjct: 274 ACSAGYYELAQVLLAMHA-NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKA-DVNAQS 331
Query: 136 DMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQE- 194
G + YA A G +++L+E + +NG TPL A GH+EV + L++
Sbjct: 332 STGNTALTYACAGGYVDVVKVLLES-GASIEDHNENGHTPLMEAGSAGHVEVARLLLENG 390
Query: 195 CGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTK 254
G + H+ + L A GH ++ +L+ + + TA+ A GH +
Sbjct: 391 AGINTHSNEFKE-SALTLACYKGHLEMVRFLLEA-GADQEHKTDEMHTALMEACMDGHVE 448
Query: 255 VLSWLLLHGGEIS--ADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLS 312
V LL G +++ AD + +PL AA G +E +L+ GA L+ + +GYT +
Sbjct: 449 VARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507
Query: 313 DFNGHSHCTRYL 324
GH L
Sbjct: 508 AREGHEEMVALL 519
Score = 65.1 bits (157), Expect = 3e-10
Identities = 68/207 (32%), Positives = 99/207 (47%), Gaps = 19/207 (9%)
Query: 134 ATDMGALPIHYAAAKGDFP---------SLRLLVEHYPE-GVNAQTK-NGATPLYLACQE 182
A+ M P H AA P S ++ YP ++AQT+ N T L LAC
Sbjct: 783 ASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAG 842
Query: 183 GHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVI-VWLVSCTDV-SLSEQDKDG 240
GH E+ Q L++ GA R G TPL AA GH V+ + L + D+ + SE+ KD
Sbjct: 843 GHEELVQTLLER-GASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD- 900
Query: 241 ATAMHFAASRGHTKVLSWLLLHG-GEISADLWGGTPLHDAAENGELECCQILVVNGAELD 299
T + A S G +V+ LL G + ++ TPL AA G + +IL+ GAE++
Sbjct: 901 -TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 959
Query: 300 VR--DRDGYTAADLSDFNGHSHCTRYL 324
R + G + L+ NGH+ + L
Sbjct: 960 SRTGSKLGISPLMLAAMNGHTAAVKLL 986
Score = 56.6 bits (135), Expect = 9e-08
Identities = 49/192 (25%), Positives = 92/192 (47%), Gaps = 4/192 (2%)
Query: 135 TDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQE 194
T+ G + A + G + ++L+ + + K TPL A GH+++ + L+
Sbjct: 264 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323
Query: 195 CGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTK 254
AD +A++ G T L A G+ V+ L+ + S+ + +++G T + A S GH +
Sbjct: 324 -KADVNAQSSTGNTALTYACAGGYVDVVKVLLE-SGASIEDHNENGHTPLMEAGSAGHVE 381
Query: 255 VLSWLLLHGGEIS--ADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLS 312
V LL +G I+ ++ + + L A G LE + L+ GA+ + + + +TA +
Sbjct: 382 VARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEA 441
Query: 313 DFNGHSHCTRYL 324
+GH R L
Sbjct: 442 CMDGHVEVARLL 453
Score = 36.6 bits (83), Expect = 0.10
Identities = 33/130 (25%), Positives = 52/130 (40%), Gaps = 8/130 (6%)
Query: 337 LSRDPSAELEAKQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQHPP 396
+SR+ + + P+ SS P+ ++ S+ SS+HS+ Q PP
Sbjct: 1804 VSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSN--QQQPP 1861
Query: 397 CGLSSARAADIQSYMDMLNPELGL---PRGTIGKPT--PPPPPPSFPPPPPPPGTQLPPP 451
+S +Q + PE+ + P T P P P ++P P P G P P
Sbjct: 1862 GSVSQEPRPPLQQ-SQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTP 1920
Query: 452 PPGYPAPKPP 461
PA +PP
Sbjct: 1921 KMETPAIRPP 1930
Score = 33.9 bits (76), Expect = 0.66
Identities = 17/69 (24%), Positives = 37/69 (53%)
Query: 760 RKMQLKMQEEEEQRRKEEEEEARLASMPAWRRDLLRKKLEEEREQKRKEEERQKQEELRR 819
+ + ++E + ++ +EE LA+ R++ RKK EE+R + + E + K+ +
Sbjct: 1203 KNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQ 1262
Query: 820 EKEQSEKLR 828
++ EKL+
Sbjct: 1263 AAQEKEKLK 1271
Score = 33.5 bits (75), Expect = 0.86
Identities = 35/143 (24%), Positives = 52/143 (36%), Gaps = 27/143 (18%)
Query: 341 PSAELEAKQPDSGMSSPNTTVSV------QPLNFDLSSPTSTLSNYDSCSSSHSSIK--G 392
P + P S SSP+ PL+ +SP S+ + + S ++
Sbjct: 1779 PMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTN 1838
Query: 393 QHPPCGLSSARAADIQSYMDMLNPELGLPRGTIGKPTPPPPPPSFPPPP------PPPGT 446
PP SS+ ++ S P G++ + PP S PPP PP T
Sbjct: 1839 TRPPNSSSSSGSSSAHSNQQQ-------PPGSVSQEPRPPLQQSQVPPPEVRMTVPPLAT 1891
Query: 447 QLPP------PPPGYPAPKPPVG 463
P P YP P+ P+G
Sbjct: 1892 SSAPVAVPSTAPVTYPMPQTPMG 1914
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 105 bits (263), Expect = 1e-22
Identities = 95/337 (28%), Positives = 143/337 (42%), Gaps = 25/337 (7%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
A G L+ + L G ++ D + P+H AA G L L+ LV A + R
Sbjct: 147 AVHSGHLETVNLLLNKGA-SLNVCDKKERQPLHWAAFLGHLEVLKLLVARGA-DLGCKDR 204
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
G H A+A+G + +++LL G + + + G T LH+A G V L++ G
Sbjct: 205 KGYGLLHTAAASGQIEVVKYLLRMGA-EIDEPNAFGNTALHIACYLGQDAVAIELVN-AG 262
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
+ D G P+H AA + L+ + VN Q+K G +PL++A G +
Sbjct: 263 ANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRS 322
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
Q L+Q G++ G TPLH AA+ GH +I L++ + + +H A
Sbjct: 323 QILIQN-GSEIDCADKFGNTPLHVAARYGHELLISTLMT-NGADTARRGIHDMFPLHLAV 380
Query: 249 SRGHTKVLSWLLLHGGEISA-------------------DLWGGTPLHDAAENGELECCQ 289
G + LL G S D G T LH AA G +EC
Sbjct: 381 LFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLN 440
Query: 290 ILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRT 326
+L+ +GA+L RD+ G T + NG C L T
Sbjct: 441 LLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVT 477
Score = 105 bits (261), Expect = 2e-22
Identities = 94/311 (30%), Positives = 147/311 (47%), Gaps = 9/311 (2%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AA G++ +L+ L +G + +D L P+H AA + L L+ +A AR +
Sbjct: 48 AAYVGDVPILQLLLMSGA-NVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSA-DVNARDK 105
Query: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
TP H A+A C + L+ + D SG + LH A GH E VN LL+ G
Sbjct: 106 LWQTPLHVAAANRATKCAE-ALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNK-G 163
Query: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
P+H+AA G L+LLV + + + + G L+ A G +EV
Sbjct: 164 ASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD-LGCKDRKGYGLLHTAAASGQIEVV 222
Query: 189 QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAA 248
+YL++ GA+ G T LH A +G V + LV+ ++++ + G T +H AA
Sbjct: 223 KYLLR-MGAEIDEPNAFGNTALHIACYLGQDAVAIELVN-AGANVNQPNDKGFTPLHVAA 280
Query: 249 -SRGHTKVLSWLLLHGGEIS-ADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGY 306
S L L+ +G +++ G +PLH AA +G QIL+ NG+E+D D+ G
Sbjct: 281 VSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGN 340
Query: 307 TAADLSDFNGH 317
T ++ GH
Sbjct: 341 TPLHVAARYGH 351
Score = 100 bits (249), Expect = 6e-21
Identities = 104/346 (30%), Positives = 149/346 (43%), Gaps = 51/346 (14%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDAL---PVHHAARAGKLHCLRFLVEEAALPAAA 65
AA G D L L +G + D +DA P+ A G + C+ L+E+ + AA
Sbjct: 659 AAASGHTDSLHLLIDSGERA-DITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAA 717
Query: 66 RARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLH 125
R G T H + TG CL LL V +D G T +HLA+ GH V+ LL
Sbjct: 718 DLR-GRTALHRGAVTGCEDCLAALLDHDAF-VLCRDFKGRTPIHLASACGHTAVLRTLLQ 775
Query: 126 HG-GGDPT-AATDM-GALPIHYAAAKGDFPSLRLLVEHYP----EG-------------- 164
DP A D G P+H+A+ G L LL+EH P EG
Sbjct: 776 AALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQ 835
Query: 165 ---------------VNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTP 209
VN++ G TPL+ A ++ + L+Q A+ +A H G T
Sbjct: 836 DSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQH-QAEVNATDHTGRTA 894
Query: 210 LHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISAD 269
L AA+ G + + +L+ L+ D++ TA+H A S+GH K +L ++
Sbjct: 895 LMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLG-- 952
Query: 270 LWGGT------PLHDAAENGELECCQILVVNGAELDVRDRDGYTAA 309
L T PLH AA NG Q L+ +GA + D +G+T A
Sbjct: 953 LINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPA 998
Score = 99.0 bits (245), Expect = 2e-20
Identities = 103/352 (29%), Positives = 144/352 (40%), Gaps = 43/352 (12%)
Query: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
AA G + L++L A L+ +RD + A G C+ L A +
Sbjct: 592 AAYNGHCEALKTL-AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERK 650
Query: 69 NGATPAHDASATGHLACLQWLLSQG-GCRVQD-KDNSGATVLHLAARFGHPEVVNWLLHH 126
TP H A+A+GH L L+ G + D D G T L LA GH + V+ LL
Sbjct: 651 RKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710
Query: 127 GGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLE 186
G AA G +H A G L L++H V + G TP++LA GH
Sbjct: 711 -GSTADAADLRGRTALHRGAVTGCEDCLAALLDH-DAFVLCRDFKGRTPIHLASACGHTA 768
Query: 187 VTQYLVQEC-GADPHARAHD--GMTPLHAAAQMGHSPVIVWLV----------------- 226
V + L+Q DP D G +P+H A+ GH + L+
Sbjct: 769 VLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLH 828
Query: 227 --------SCTDVSL--------SEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-D 269
S T++ L + +D G T +H AA + L LL H E++A D
Sbjct: 829 CAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATD 888
Query: 270 LWGGTPLHDAAENGELECCQILVVNG-AELDVRDRDGYTAADLSDFNGHSHC 320
G T L AAENG+ + L+ G A+L V D + TA L+ GH C
Sbjct: 889 HTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKC 940
Score = 92.0 bits (227), Expect = 2e-18
Identities = 95/315 (30%), Positives = 126/315 (40%), Gaps = 36/315 (11%)
Query: 33 DPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQ 92
D P+H AAR G + L+ A A R + P H A G C + LLS
Sbjct: 336 DKFGNTPLHVAARYGHELLISTLMTNGA-DTARRGIHDMFPLHLAVLFGFSDCCRKLLSS 394
Query: 93 G-----------------GCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAAT 135
G G + DN G T LH AA G+ E +N LL G D
Sbjct: 395 GQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLS-SGADLRRRD 453
Query: 136 DMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQEC 195
G P+HYAAA G + LV GVN G +PL+ A
Sbjct: 454 KFGRTPLHYAAANGSYQCAVTLVTA-GAGVNEADCKGCSPLHYAAASDTYR--------- 503
Query: 196 GADPHA-RAHDGMT--PLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGH 252
A+PH +HD PL + + + +L+ S +D+ G TA+H+AA+ G+
Sbjct: 504 RAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLD-NGADPSLRDRQGYTAVHYAAAYGN 562
Query: 253 TKVLSWLLLHGGEISADLWGG---TPLHDAAENGELECCQILVVNGAELDVRDRDGYTAA 309
+ L LL D+ +PLH AA NG E + L LDVRD G TA
Sbjct: 563 RQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTAL 622
Query: 310 DLSDFNGHSHCTRYL 324
L+ G + C L
Sbjct: 623 FLATERGSTECVEVL 637
Score = 87.8 bits (216), Expect = 4e-17
Identities = 108/390 (27%), Positives = 153/390 (39%), Gaps = 83/390 (21%)
Query: 33 DPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQ 92
D L +H AA G + CL L+ A R + G TP H A+A G C L++
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLLSSGA-DLRRRDKFGRTPLHYAAANGSYQCAVTLVT- 477
Query: 93 GGCRVQDKDNSGATVLHLAA-----RFGHPEV-----------------------VNWLL 124
G V + D G + LH AA R P + +LL
Sbjct: 478 AGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLL 537
Query: 125 HHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGV-NAQTKNGATPLYLACQEG 183
+G DP+ G +HYAAA G+ +L LL+E + + ++ +PL+LA G
Sbjct: 538 DNGA-DPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNG 596
Query: 184 HLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATA 243
H E + L + + R H G T L A + G + + L + +L ++ K T
Sbjct: 597 HCEALKTLAETL-VNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTP 655
Query: 244 MHFAASRGHTKVLSWLLLHGGEIS------------------------------------ 267
+H AA+ GHT L LL+ GE +
Sbjct: 656 LHAAAASGHTDSLH-LLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTA 714
Query: 268 --ADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLR 325
ADL G T LH A G +C L+ + A + RD G T L+ GH T LR
Sbjct: 715 DAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGH---TAVLR 771
Query: 326 TVENLSVEHRVLSRDPSAELEAKQPDSGMS 355
T+ + LS DP L+A SG S
Sbjct: 772 TLLQAA-----LSTDP---LDAGVDYSGYS 793
Score = 80.1 bits (196), Expect = 8e-15
Identities = 63/185 (34%), Positives = 89/185 (48%), Gaps = 4/185 (2%)
Query: 141 PIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPH 200
P+H AA GD P L+LL+ VNA+ TPL+ A + +V L+ AD +
Sbjct: 44 PLHAAAYVGDVPILQLLLMS-GANVNAKDTLWLTPLHRAAASRNEKVLGLLLAH-SADVN 101
Query: 201 ARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLL 260
AR TPLH AA + L SL+ D+ G +A+H A GH + ++ LL
Sbjct: 102 ARDKLWQTPLHVAAANRATKCAEALAPLLS-SLNVADRSGRSALHHAVHSGHLETVNLLL 160
Query: 261 LHGGEIS-ADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSH 319
G ++ D PLH AA G LE ++LV GA+L +DR GY + +G
Sbjct: 161 NKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIE 220
Query: 320 CTRYL 324
+YL
Sbjct: 221 VVKYL 225
Score = 63.2 bits (152), Expect = 1e-09
Identities = 41/112 (36%), Positives = 63/112 (56%), Gaps = 4/112 (3%)
Query: 208 TPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEIS 267
TPLHAAA +G P++ L+ + +++ +D T +H AA+ + KVL LL H +++
Sbjct: 43 TPLHAAAYVGDVPILQLLLM-SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVN 101
Query: 268 A--DLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGH 317
A LW TPLH AA N +C + L + L+V DR G +A + +GH
Sbjct: 102 ARDKLWQ-TPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGH 152
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/90 (30%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 237 DKDGATAMHFAASRGHTKVLSWLLLHGGEISAD--LWGGTPLHDAAENGELECCQILVVN 294
D++ T +H AA G +L LL+ G ++A LW TPLH AA + + +L+ +
Sbjct: 38 DQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWL-TPLHRAAASRNEKVLGLLLAH 96
Query: 295 GAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
A+++ RD+ T ++ N + C L
Sbjct: 97 SADVNARDKLWQTPLHVAAANRATKCAEAL 126
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,679,038
Number of Sequences: 37866
Number of extensions: 3421416
Number of successful extensions: 132825
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1932
Number of HSP's successfully gapped in prelim test: 2020
Number of HSP's that attempted gapping in prelim test: 28330
Number of HSP's gapped (non-prelim): 44506
length of query: 854
length of database: 18,247,518
effective HSP length: 111
effective length of query: 743
effective length of database: 14,044,392
effective search space: 10434983256
effective search space used: 10434983256
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.