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Search of human proteins with 155369221
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|155369221 potassium channel tetramerisation domain
containing 19 [Homo sapiens]
(926 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|155369221 potassium channel tetramerisation domain containing... 1900 0.0
gi|218505694 potassium channel tetramerisation domain containing... 68 3e-11
gi|209969708 potassium channel tetramerisation domain containing... 68 3e-11
gi|40217617 potassium channel tetramerisation domain containing ... 68 3e-11
gi|194018443 potassium channel tetramerisation domain containing... 65 3e-10
gi|194018441 potassium channel tetramerisation domain containing... 65 3e-10
gi|194018439 potassium channel tetramerisation domain containing... 65 3e-10
gi|146198864 potassium channel tetramerisation domain containing... 62 2e-09
gi|189571693 potassium channel tetramerisation domain containing... 58 4e-08
gi|189571691 potassium channel tetramerisation domain containing... 58 4e-08
gi|71143104 potassium channel tetramerisation domain containing ... 55 4e-07
gi|51036594 potassium channel tetramerisation domain containing ... 52 3e-06
gi|40807368 potassium channel regulator isoform 2 [Homo sapiens] 47 1e-04
gi|27734697 potassium channel regulator isoform 1 [Homo sapiens] 47 1e-04
gi|19923973 potassium channel tetramerisation domain containing ... 46 2e-04
gi|55926200 potassium channel tetramerisation domain containing ... 45 4e-04
gi|223005950 SH3KBP1 binding protein 1 [Homo sapiens] 44 5e-04
gi|45387953 potassium channel tetramerization domain containing ... 42 0.002
gi|46255026 potassium channel tetramerisation domain containing ... 42 0.002
gi|23308551 potassium channel tetramerisation domain containing ... 42 0.003
gi|9789987 potassium voltage-gated channel, Shal-related subfami... 41 0.005
gi|27436981 potassium voltage-gated channel, Shal-related subfam... 40 0.008
gi|25952108 potassium voltage-gated channel delayed-rectifier pr... 40 0.010
gi|142356950 potassium channel tetramerisation domain containing... 40 0.013
gi|27436984 potassium voltage-gated channel, Shal-related subfam... 39 0.022
gi|27436986 potassium voltage-gated channel, Shal-related subfam... 39 0.022
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 39 0.022
gi|13994353 potassium channel tetramerisation domain containing ... 39 0.029
gi|68303635 mutS homolog 3 [Homo sapiens] 38 0.038
gi|13376611 zinc finger protein 703 [Homo sapiens] 36 0.14
>gi|155369221 potassium channel tetramerisation domain containing 19
[Homo sapiens]
Length = 926
Score = 1900 bits (4923), Expect = 0.0
Identities = 926/926 (100%), Positives = 926/926 (100%)
Query: 1 MEESGMAHESAEDLFHFNVGGWHFSVPRSKLSQFPDSLLWKEASALTSSESQRLFIDRDG 60
MEESGMAHESAEDLFHFNVGGWHFSVPRSKLSQFPDSLLWKEASALTSSESQRLFIDRDG
Sbjct: 1 MEESGMAHESAEDLFHFNVGGWHFSVPRSKLSQFPDSLLWKEASALTSSESQRLFIDRDG 60
Query: 61 STFRHVHYYLYTSKLSFSSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRVRPADLP 120
STFRHVHYYLYTSKLSFSSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRVRPADLP
Sbjct: 61 STFRHVHYYLYTSKLSFSSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRVRPADLP 120
Query: 121 VAERASLNYWRTWKCISKPSEFPIKSPAFTGLHDKAPLGLMDTPLLDTEEEVHYCFLPLD 180
VAERASLNYWRTWKCISKPSEFPIKSPAFTGLHDKAPLGLMDTPLLDTEEEVHYCFLPLD
Sbjct: 121 VAERASLNYWRTWKCISKPSEFPIKSPAFTGLHDKAPLGLMDTPLLDTEEEVHYCFLPLD 180
Query: 181 LVAKYPSLVTEDNLLWLAETVALIECECSEFRFIVNFLRSQKILLPDNFSNIDVLEAEVE 240
LVAKYPSLVTEDNLLWLAETVALIECECSEFRFIVNFLRSQKILLPDNFSNIDVLEAEVE
Sbjct: 181 LVAKYPSLVTEDNLLWLAETVALIECECSEFRFIVNFLRSQKILLPDNFSNIDVLEAEVE 240
Query: 241 ILEIPALTEAVRWYRMNMGGCSPTTCSPLSPGKGARTASLESVKPLYTMALGLLVKYPDS 300
ILEIPALTEAVRWYRMNMGGCSPTTCSPLSPGKGARTASLESVKPLYTMALGLLVKYPDS
Sbjct: 241 ILEIPALTEAVRWYRMNMGGCSPTTCSPLSPGKGARTASLESVKPLYTMALGLLVKYPDS 300
Query: 301 ALGQLRIESTLDGSRLYITGNGVLFQHVKNWLGTCRLPLTETISEVYELCAFLDKRDITY 360
ALGQLRIESTLDGSRLYITGNGVLFQHVKNWLGTCRLPLTETISEVYELCAFLDKRDITY
Sbjct: 301 ALGQLRIESTLDGSRLYITGNGVLFQHVKNWLGTCRLPLTETISEVYELCAFLDKRDITY 360
Query: 361 EPIKVALKTHLEPRTLAPMDVLNEWTAEITVYSPQQIIKVYVGSHWYATTLQTLLKYPEL 420
EPIKVALKTHLEPRTLAPMDVLNEWTAEITVYSPQQIIKVYVGSHWYATTLQTLLKYPEL
Sbjct: 361 EPIKVALKTHLEPRTLAPMDVLNEWTAEITVYSPQQIIKVYVGSHWYATTLQTLLKYPEL 420
Query: 421 LSNPQRVYWITYGQTLLIHGDGQMFRHILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPS 480
LSNPQRVYWITYGQTLLIHGDGQMFRHILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPS
Sbjct: 421 LSNPQRVYWITYGQTLLIHGDGQMFRHILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPS 480
Query: 481 LSEALAQCEAYKSWTQEKESENEEAFSIRRLHVVTEGPGSLVEFSRDTKETTAYMPVDFE 540
LSEALAQCEAYKSWTQEKESENEEAFSIRRLHVVTEGPGSLVEFSRDTKETTAYMPVDFE
Sbjct: 481 LSEALAQCEAYKSWTQEKESENEEAFSIRRLHVVTEGPGSLVEFSRDTKETTAYMPVDFE 540
Query: 541 DCSDRTPWNKAKGNLVRSNQMDEAEQYTRPIQVSLCRNAKRAGNPSTYSHCRGLCTNPGH 600
DCSDRTPWNKAKGNLVRSNQMDEAEQYTRPIQVSLCRNAKRAGNPSTYSHCRGLCTNPGH
Sbjct: 541 DCSDRTPWNKAKGNLVRSNQMDEAEQYTRPIQVSLCRNAKRAGNPSTYSHCRGLCTNPGH 600
Query: 601 WGSHPESPPKKKCTTINLTQKSETKDPPATPMQKLISLVREWDMVNCKQWEFQPLTATRS 660
WGSHPESPPKKKCTTINLTQKSETKDPPATPMQKLISLVREWDMVNCKQWEFQPLTATRS
Sbjct: 601 WGSHPESPPKKKCTTINLTQKSETKDPPATPMQKLISLVREWDMVNCKQWEFQPLTATRS 660
Query: 661 SPLEEATLQLPLGSEAASQPSTSAAWKAHSTASEKDPGPQAGAGAGAKDKGPEPTFKPYL 720
SPLEEATLQLPLGSEAASQPSTSAAWKAHSTASEKDPGPQAGAGAGAKDKGPEPTFKPYL
Sbjct: 661 SPLEEATLQLPLGSEAASQPSTSAAWKAHSTASEKDPGPQAGAGAGAKDKGPEPTFKPYL 720
Query: 721 PPKRAGTLKDWSKQRTKERESPAPEQPLPEASEVDSLGVILKVTHPPVVGSDGFCMFFED 780
PPKRAGTLKDWSKQRTKERESPAPEQPLPEASEVDSLGVILKVTHPPVVGSDGFCMFFED
Sbjct: 721 PPKRAGTLKDWSKQRTKERESPAPEQPLPEASEVDSLGVILKVTHPPVVGSDGFCMFFED 780
Query: 781 SIIYTTEMDNLRHTTPTASPQPQEVTFLSFSLSWEEMFYAQKCHCFLADIIMDSIRQKDP 840
SIIYTTEMDNLRHTTPTASPQPQEVTFLSFSLSWEEMFYAQKCHCFLADIIMDSIRQKDP
Sbjct: 781 SIIYTTEMDNLRHTTPTASPQPQEVTFLSFSLSWEEMFYAQKCHCFLADIIMDSIRQKDP 840
Query: 841 KAITAKVVSLANRLWTLHISPKQFVVDLLAITGFKDDRHTQERLYSWVELTLPFARKYGR 900
KAITAKVVSLANRLWTLHISPKQFVVDLLAITGFKDDRHTQERLYSWVELTLPFARKYGR
Sbjct: 841 KAITAKVVSLANRLWTLHISPKQFVVDLLAITGFKDDRHTQERLYSWVELTLPFARKYGR 900
Query: 901 CMDLLIQRGLSRSVSYSILGKYLQED 926
CMDLLIQRGLSRSVSYSILGKYLQED
Sbjct: 901 CMDLLIQRGLSRSVSYSILGKYLQED 926
>gi|218505694 potassium channel tetramerisation domain containing 1
isoform b [Homo sapiens]
Length = 865
Score = 68.2 bits (165), Expect = 3e-11
Identities = 39/109 (35%), Positives = 59/109 (54%), Gaps = 13/109 (11%)
Query: 398 IKVYVGSHWYATTLQTLLKYPE-----LLSNPQRVYWITYGQTLLIHGDGQMFRHILNFL 452
+ + VG H Y ++L TL KYPE L + + + Q I DGQMFR+ILNFL
Sbjct: 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFL 699
Query: 453 RLGKLFLPSEFKEWPLFCQEVEEYHI-PSLSEALAQCEAYKSWTQEKES 500
R KL +P +FK++ L +E + + + P L E + W Q++E+
Sbjct: 700 RTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLE-------MERWKQDRET 741
Score = 54.3 bits (129), Expect = 5e-07
Identities = 37/116 (31%), Positives = 59/116 (50%), Gaps = 6/116 (5%)
Query: 16 HFNVGGWHFSVPRSKLSQFPDSLLWK----EASALTSSESQRLFIDRDGSTFRHVHYYLY 71
H +VGG ++ + L+++P+S + + + S Q FIDRDG FR++ +L
Sbjct: 641 HIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLR 700
Query: 72 TSKLSF-SSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRV-RPADLPVAERA 125
TSKL + LLYE+A QL P+L ++ K+ + R RP + V A
Sbjct: 701 TSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRETGRFSRPCECLVVRVA 756
Score = 42.7 bits (99), Expect = 0.002
Identities = 19/44 (43%), Positives = 30/44 (68%), Gaps = 1/44 (2%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEI-PALTEAVRW 253
FR+I+NFLR+ K+L+PD+F + +L E + ++ P L E RW
Sbjct: 692 FRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERW 735
Score = 33.5 bits (75), Expect = 0.94
Identities = 20/66 (30%), Positives = 37/66 (56%), Gaps = 7/66 (10%)
Query: 286 LYTMALGLLVKYPDSALGQLRIEST----LDG--SRLYITGNGVLFQHVKNWLGTCRLPL 339
+YT +L L KYP+S +G+L + T LD +I +G +F+++ N+L T +L +
Sbjct: 648 MYTSSLATLTKYPESRIGRL-FDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLI 706
Query: 340 TETISE 345
+ +
Sbjct: 707 PDDFKD 712
>gi|209969708 potassium channel tetramerisation domain containing 1
isoform a [Homo sapiens]
Length = 257
Score = 68.2 bits (165), Expect = 3e-11
Identities = 39/109 (35%), Positives = 59/109 (54%), Gaps = 13/109 (11%)
Query: 398 IKVYVGSHWYATTLQTLLKYPE-----LLSNPQRVYWITYGQTLLIHGDGQMFRHILNFL 452
+ + VG H Y ++L TL KYPE L + + + Q I DGQMFR+ILNFL
Sbjct: 32 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFL 91
Query: 453 RLGKLFLPSEFKEWPLFCQEVEEYHI-PSLSEALAQCEAYKSWTQEKES 500
R KL +P +FK++ L +E + + + P L E + W Q++E+
Sbjct: 92 RTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLE-------MERWKQDRET 133
Score = 54.3 bits (129), Expect = 5e-07
Identities = 37/116 (31%), Positives = 59/116 (50%), Gaps = 6/116 (5%)
Query: 16 HFNVGGWHFSVPRSKLSQFPDSLLWK----EASALTSSESQRLFIDRDGSTFRHVHYYLY 71
H +VGG ++ + L+++P+S + + + S Q FIDRDG FR++ +L
Sbjct: 33 HIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLR 92
Query: 72 TSKLSF-SSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRV-RPADLPVAERA 125
TSKL + LLYE+A QL P+L ++ K+ + R RP + V A
Sbjct: 93 TSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRETGRFSRPCECLVVRVA 148
Score = 42.7 bits (99), Expect = 0.002
Identities = 19/44 (43%), Positives = 30/44 (68%), Gaps = 1/44 (2%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEI-PALTEAVRW 253
FR+I+NFLR+ K+L+PD+F + +L E + ++ P L E RW
Sbjct: 84 FRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERW 127
Score = 33.5 bits (75), Expect = 0.94
Identities = 20/66 (30%), Positives = 37/66 (56%), Gaps = 7/66 (10%)
Query: 286 LYTMALGLLVKYPDSALGQLRIEST----LDG--SRLYITGNGVLFQHVKNWLGTCRLPL 339
+YT +L L KYP+S +G+L + T LD +I +G +F+++ N+L T +L +
Sbjct: 40 MYTSSLATLTKYPESRIGRL-FDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLI 98
Query: 340 TETISE 345
+ +
Sbjct: 99 PDDFKD 104
>gi|40217617 potassium channel tetramerisation domain containing 1
isoform a [Homo sapiens]
Length = 257
Score = 68.2 bits (165), Expect = 3e-11
Identities = 39/109 (35%), Positives = 59/109 (54%), Gaps = 13/109 (11%)
Query: 398 IKVYVGSHWYATTLQTLLKYPE-----LLSNPQRVYWITYGQTLLIHGDGQMFRHILNFL 452
+ + VG H Y ++L TL KYPE L + + + Q I DGQMFR+ILNFL
Sbjct: 32 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFL 91
Query: 453 RLGKLFLPSEFKEWPLFCQEVEEYHI-PSLSEALAQCEAYKSWTQEKES 500
R KL +P +FK++ L +E + + + P L E + W Q++E+
Sbjct: 92 RTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLE-------MERWKQDRET 133
Score = 54.3 bits (129), Expect = 5e-07
Identities = 37/116 (31%), Positives = 59/116 (50%), Gaps = 6/116 (5%)
Query: 16 HFNVGGWHFSVPRSKLSQFPDSLLWK----EASALTSSESQRLFIDRDGSTFRHVHYYLY 71
H +VGG ++ + L+++P+S + + + S Q FIDRDG FR++ +L
Sbjct: 33 HIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLR 92
Query: 72 TSKLSF-SSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRV-RPADLPVAERA 125
TSKL + LLYE+A QL P+L ++ K+ + R RP + V A
Sbjct: 93 TSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRETGRFSRPCECLVVRVA 148
Score = 42.7 bits (99), Expect = 0.002
Identities = 19/44 (43%), Positives = 30/44 (68%), Gaps = 1/44 (2%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEI-PALTEAVRW 253
FR+I+NFLR+ K+L+PD+F + +L E + ++ P L E RW
Sbjct: 84 FRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERW 127
Score = 33.5 bits (75), Expect = 0.94
Identities = 20/66 (30%), Positives = 37/66 (56%), Gaps = 7/66 (10%)
Query: 286 LYTMALGLLVKYPDSALGQLRIEST----LDG--SRLYITGNGVLFQHVKNWLGTCRLPL 339
+YT +L L KYP+S +G+L + T LD +I +G +F+++ N+L T +L +
Sbjct: 40 MYTSSLATLTKYPESRIGRL-FDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLI 98
Query: 340 TETISE 345
+ +
Sbjct: 99 PDDFKD 104
>gi|194018443 potassium channel tetramerisation domain containing 15
isoform 2 [Homo sapiens]
Length = 283
Score = 65.1 bits (157), Expect = 3e-10
Identities = 35/107 (32%), Positives = 57/107 (53%), Gaps = 11/107 (10%)
Query: 398 IKVYVGSHWYATTLQTLLKYPE-----LLSNPQRVYWITYGQTLLIHGDGQMFRHILNFL 452
+ + VG H Y ++L TL KYP+ L + + + + Q I DG++FR++L+FL
Sbjct: 58 VHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYVLSFL 117
Query: 453 RLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQCEAYKSWTQEKE 499
R KL LP +FK++ L +E Y + + L + W QE+E
Sbjct: 118 RTSKLLLPDDFKDFSLLYEEARYYQLQPMVREL------ERWQQEQE 158
Score = 55.5 bits (132), Expect = 2e-07
Identities = 34/103 (33%), Positives = 57/103 (55%), Gaps = 5/103 (4%)
Query: 16 HFNVGGWHFSVPRSKLSQFPDSLLWKEASA----LTSSESQRLFIDRDGSTFRHVHYYLY 71
H +VGG ++ + L+++PDS + + + + S Q FIDRDG FR+V +L
Sbjct: 59 HIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLR 118
Query: 72 TSKLSF-SSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLR 113
TSKL + +LLYE+A QL P+++ L+ ++ + R
Sbjct: 119 TSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRR 161
Score = 40.0 bits (92), Expect = 0.010
Identities = 17/44 (38%), Positives = 29/44 (65%), Gaps = 1/44 (2%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEI-PALTEAVRW 253
FR++++FLR+ K+LLPD+F + +L E ++ P + E RW
Sbjct: 110 FRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERW 153
Score = 31.6 bits (70), Expect = 3.6
Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 5/65 (7%)
Query: 286 LYTMALGLLVKYPDSALGQL---RIESTLDG--SRLYITGNGVLFQHVKNWLGTCRLPLT 340
+YT +L L KYPDS + +L LD +I +G +F++V ++L T +L L
Sbjct: 66 MYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLP 125
Query: 341 ETISE 345
+ +
Sbjct: 126 DDFKD 130
>gi|194018441 potassium channel tetramerisation domain containing 15
isoform 2 [Homo sapiens]
Length = 283
Score = 65.1 bits (157), Expect = 3e-10
Identities = 35/107 (32%), Positives = 57/107 (53%), Gaps = 11/107 (10%)
Query: 398 IKVYVGSHWYATTLQTLLKYPE-----LLSNPQRVYWITYGQTLLIHGDGQMFRHILNFL 452
+ + VG H Y ++L TL KYP+ L + + + + Q I DG++FR++L+FL
Sbjct: 58 VHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYVLSFL 117
Query: 453 RLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQCEAYKSWTQEKE 499
R KL LP +FK++ L +E Y + + L + W QE+E
Sbjct: 118 RTSKLLLPDDFKDFSLLYEEARYYQLQPMVREL------ERWQQEQE 158
Score = 55.5 bits (132), Expect = 2e-07
Identities = 34/103 (33%), Positives = 57/103 (55%), Gaps = 5/103 (4%)
Query: 16 HFNVGGWHFSVPRSKLSQFPDSLLWKEASA----LTSSESQRLFIDRDGSTFRHVHYYLY 71
H +VGG ++ + L+++PDS + + + + S Q FIDRDG FR+V +L
Sbjct: 59 HIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLR 118
Query: 72 TSKLSF-SSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLR 113
TSKL + +LLYE+A QL P+++ L+ ++ + R
Sbjct: 119 TSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRR 161
Score = 40.0 bits (92), Expect = 0.010
Identities = 17/44 (38%), Positives = 29/44 (65%), Gaps = 1/44 (2%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEI-PALTEAVRW 253
FR++++FLR+ K+LLPD+F + +L E ++ P + E RW
Sbjct: 110 FRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERW 153
Score = 31.6 bits (70), Expect = 3.6
Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 5/65 (7%)
Query: 286 LYTMALGLLVKYPDSALGQL---RIESTLDG--SRLYITGNGVLFQHVKNWLGTCRLPLT 340
+YT +L L KYPDS + +L LD +I +G +F++V ++L T +L L
Sbjct: 66 MYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLP 125
Query: 341 ETISE 345
+ +
Sbjct: 126 DDFKD 130
>gi|194018439 potassium channel tetramerisation domain containing 15
isoform 1 [Homo sapiens]
Length = 234
Score = 65.1 bits (157), Expect = 3e-10
Identities = 35/107 (32%), Positives = 57/107 (53%), Gaps = 11/107 (10%)
Query: 398 IKVYVGSHWYATTLQTLLKYPE-----LLSNPQRVYWITYGQTLLIHGDGQMFRHILNFL 452
+ + VG H Y ++L TL KYP+ L + + + + Q I DG++FR++L+FL
Sbjct: 58 VHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYVLSFL 117
Query: 453 RLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQCEAYKSWTQEKE 499
R KL LP +FK++ L +E Y + + L + W QE+E
Sbjct: 118 RTSKLLLPDDFKDFSLLYEEARYYQLQPMVREL------ERWQQEQE 158
Score = 55.5 bits (132), Expect = 2e-07
Identities = 34/103 (33%), Positives = 57/103 (55%), Gaps = 5/103 (4%)
Query: 16 HFNVGGWHFSVPRSKLSQFPDSLLWKEASA----LTSSESQRLFIDRDGSTFRHVHYYLY 71
H +VGG ++ + L+++PDS + + + + S Q FIDRDG FR+V +L
Sbjct: 59 HIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLR 118
Query: 72 TSKLSF-SSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLR 113
TSKL + +LLYE+A QL P+++ L+ ++ + R
Sbjct: 119 TSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRR 161
Score = 40.0 bits (92), Expect = 0.010
Identities = 17/44 (38%), Positives = 29/44 (65%), Gaps = 1/44 (2%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEI-PALTEAVRW 253
FR++++FLR+ K+LLPD+F + +L E ++ P + E RW
Sbjct: 110 FRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERW 153
Score = 31.6 bits (70), Expect = 3.6
Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 5/65 (7%)
Query: 286 LYTMALGLLVKYPDSALGQL---RIESTLDG--SRLYITGNGVLFQHVKNWLGTCRLPLT 340
+YT +L L KYPDS + +L LD +I +G +F++V ++L T +L L
Sbjct: 66 MYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLP 125
Query: 341 ETISE 345
+ +
Sbjct: 126 DDFKD 130
>gi|146198864 potassium channel tetramerisation domain containing 4
[Homo sapiens]
Length = 259
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/119 (34%), Positives = 58/119 (48%), Gaps = 19/119 (15%)
Query: 397 IIKVYVGSHWYATTLQTLLKYPELLSNPQRVYWITYGQTL---------LIHGDGQMFRH 447
++ + VG + Y T QTL KYP+ + I G+ L I DG +FRH
Sbjct: 34 LMTLNVGGYLYITQKQTLTKYPDTF-----LEGIVNGKILCPFDADGHYFIDRDGLLFRH 88
Query: 448 ILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQCEAYKSWTQEKESENEEAF 506
+LNFLR G+L LP F+E L QE E + + L+E E W +E+ + E F
Sbjct: 89 VLNFLRNGELLLPEGFRENQLLAQEAEFFQLKGLAE-----EVKSRWEKEQLTPRETTF 142
Score = 38.9 bits (89), Expect = 0.022
Identities = 29/104 (27%), Positives = 45/104 (43%), Gaps = 4/104 (3%)
Query: 1 MEESGMAHESAEDLFHFNVGGWHFSVPRSKLSQFPDSLLWKEASA---LTSSESQRLFID 57
+E++ L NVGG+ + + L+++PD+ L + FID
Sbjct: 21 LEDTDQGKNCKSTLMTLNVGGYLYITQKQTLTKYPDTFLEGIVNGKILCPFDADGHYFID 80
Query: 58 RDGSTFRHVHYYLYTSKLSF-SSCAELNLLYEQALGLQLMPLLQ 100
RDG FRHV +L +L E LL ++A QL L +
Sbjct: 81 RDGLLFRHVLNFLRNGELLLPEGFRENQLLAQEAEFFQLKGLAE 124
Score = 38.1 bits (87), Expect = 0.038
Identities = 18/45 (40%), Positives = 27/45 (60%), Gaps = 2/45 (4%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPALTEAV--RW 253
FR ++NFLR+ ++LLP+ F +L E E ++ L E V RW
Sbjct: 86 FRHVLNFLRNGELLLPEGFRENQLLAQEAEFFQLKGLAEEVKSRW 130
Score = 31.2 bits (69), Expect = 4.7
Identities = 23/65 (35%), Positives = 31/65 (47%), Gaps = 6/65 (9%)
Query: 286 LYTMALGLLVKYPDSAL-----GQLRIESTLDGSRLYITGNGVLFQHVKNWLGTCRLPLT 340
LY L KYPD+ L G++ DG +I +G+LF+HV N+L L L
Sbjct: 43 LYITQKQTLTKYPDTFLEGIVNGKILCPFDADG-HYFIDRDGLLFRHVLNFLRNGELLLP 101
Query: 341 ETISE 345
E E
Sbjct: 102 EGFRE 106
>gi|189571693 potassium channel tetramerisation domain containing 6
[Homo sapiens]
Length = 237
Score = 58.2 bits (139), Expect = 4e-08
Identities = 35/100 (35%), Positives = 52/100 (52%), Gaps = 20/100 (20%)
Query: 398 IKVYVGSHWYATTLQTLLKYPELL------------SNPQRVYWITYGQTLLIHGDGQMF 445
+ + VG H Y T+L TL +YP+ + +PQ Y+I DG +F
Sbjct: 14 VTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDR--------DGPLF 65
Query: 446 RHILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEAL 485
R++LNFLR +L LP +FKE+ L +E + Y I L + L
Sbjct: 66 RYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCL 105
Score = 48.1 bits (113), Expect = 4e-05
Identities = 34/93 (36%), Positives = 54/93 (58%), Gaps = 4/93 (4%)
Query: 18 NVGGWHFSVPRSKLSQFPDSLLWKEASA--LTSSESQ-RLFIDRDGSTFRHVHYYLYTSK 74
NVGG ++ + L+++PDS+L T+ + Q FIDRDG FR+V +L TS+
Sbjct: 17 NVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSE 76
Query: 75 LSFS-SCAELNLLYEQALGLQLMPLLQTLDNLK 106
L+ E +LL ++A Q+ PL+Q L++ K
Sbjct: 77 LTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPK 109
Score = 40.0 bits (92), Expect = 0.010
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 9/103 (8%)
Query: 286 LYTMALGLLVKYPDSALGQL---RIESTLD-GSRLYITGNGVLFQHVKNWLGTCRLPLTE 341
LYT +L L +YPDS LG + + D +I +G LF++V N+L T L L
Sbjct: 22 LYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPL 81
Query: 342 TISEVYELCAFLDKRDITYEPIKVALKTHLEPRTLAPMDVLNE 384
E L +++ + I+ ++ +P+ L PMD E
Sbjct: 82 DFKEFDLL-----RKEADFYQIEPLIQCLNDPKPLYPMDTFEE 119
Score = 36.2 bits (82), Expect = 0.14
Identities = 14/41 (34%), Positives = 26/41 (63%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPALTEAV 251
FR+++NFLR+ ++ LP +F D+L E + +I L + +
Sbjct: 65 FRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCL 105
>gi|189571691 potassium channel tetramerisation domain containing 6
[Homo sapiens]
Length = 237
Score = 58.2 bits (139), Expect = 4e-08
Identities = 35/100 (35%), Positives = 52/100 (52%), Gaps = 20/100 (20%)
Query: 398 IKVYVGSHWYATTLQTLLKYPELL------------SNPQRVYWITYGQTLLIHGDGQMF 445
+ + VG H Y T+L TL +YP+ + +PQ Y+I DG +F
Sbjct: 14 VTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDR--------DGPLF 65
Query: 446 RHILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEAL 485
R++LNFLR +L LP +FKE+ L +E + Y I L + L
Sbjct: 66 RYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCL 105
Score = 48.1 bits (113), Expect = 4e-05
Identities = 34/93 (36%), Positives = 54/93 (58%), Gaps = 4/93 (4%)
Query: 18 NVGGWHFSVPRSKLSQFPDSLLWKEASA--LTSSESQ-RLFIDRDGSTFRHVHYYLYTSK 74
NVGG ++ + L+++PDS+L T+ + Q FIDRDG FR+V +L TS+
Sbjct: 17 NVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSE 76
Query: 75 LSFS-SCAELNLLYEQALGLQLMPLLQTLDNLK 106
L+ E +LL ++A Q+ PL+Q L++ K
Sbjct: 77 LTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPK 109
Score = 40.0 bits (92), Expect = 0.010
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 9/103 (8%)
Query: 286 LYTMALGLLVKYPDSALGQL---RIESTLD-GSRLYITGNGVLFQHVKNWLGTCRLPLTE 341
LYT +L L +YPDS LG + + D +I +G LF++V N+L T L L
Sbjct: 22 LYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPL 81
Query: 342 TISEVYELCAFLDKRDITYEPIKVALKTHLEPRTLAPMDVLNE 384
E L +++ + I+ ++ +P+ L PMD E
Sbjct: 82 DFKEFDLL-----RKEADFYQIEPLIQCLNDPKPLYPMDTFEE 119
Score = 36.2 bits (82), Expect = 0.14
Identities = 14/41 (34%), Positives = 26/41 (63%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPALTEAV 251
FR+++NFLR+ ++ LP +F D+L E + +I L + +
Sbjct: 65 FRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCL 105
>gi|71143104 potassium channel tetramerisation domain containing 21
[Homo sapiens]
Length = 260
Score = 54.7 bits (130), Expect = 4e-07
Identities = 43/133 (32%), Positives = 61/133 (45%), Gaps = 16/133 (12%)
Query: 398 IKVYVGSHWYATTLQTLLKYPE-----LLSNPQRVYWITYGQTLLIHGDGQMFRHILNFL 452
I + VG Y T+L TL +P+ + S + G I DG++FR+ILNFL
Sbjct: 5 ITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCF-IDRDGKVFRYILNFL 63
Query: 453 RLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQCEAYKSWTQEKESENEEAFSIRRLH 512
R L LP +F+E L +E + Y + L EAL QEKE E +A L+
Sbjct: 64 RTSHLDLPEDFQEMGLLRREADFYQVQPLIEAL----------QEKEVELSKAEKNAMLN 113
Query: 513 VVTEGPGSLVEFS 525
+ V F+
Sbjct: 114 ITLNQRVQTVHFT 126
Score = 50.1 bits (118), Expect = 1e-05
Identities = 35/94 (37%), Positives = 49/94 (52%), Gaps = 4/94 (4%)
Query: 13 DLFHFNVGGWHFSVPRSKLSQFPDSLLWKEASAL--TSSESQ-RLFIDRDGSTFRHVHYY 69
D NVGG ++ + L+ FPDS+L S T +SQ FIDRDG FR++ +
Sbjct: 3 DPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYILNF 62
Query: 70 LYTSKLSF-SSCAELNLLYEQALGLQLMPLLQTL 102
L TS L E+ LL +A Q+ PL++ L
Sbjct: 63 LRTSHLDLPEDFQEMGLLRREADFYQVQPLIEAL 96
Score = 40.4 bits (93), Expect = 0.008
Identities = 24/116 (20%), Positives = 55/116 (47%), Gaps = 2/116 (1%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPALTEAVRWYRMNMGGCSPTTCSPLS 270
FR+I+NFLR+ + LP++F + +L E + ++ L EA++ + + ++
Sbjct: 56 FRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEVELSKAEKNAMLNIT 115
Query: 271 PGKGARTA--SLESVKPLYTMALGLLVKYPDSALGQLRIESTLDGSRLYITGNGVL 324
+ +T ++ +Y+++ + + + + L GS+L+ NG L
Sbjct: 116 LNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLFYCSNGNL 171
Score = 35.8 bits (81), Expect = 0.19
Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 4/65 (6%)
Query: 286 LYTMALGLLVKYPDSALGQL---RIESTLDG-SRLYITGNGVLFQHVKNWLGTCRLPLTE 341
LYT +L L +PDS LG + ++ + D +I +G +F+++ N+L T L L E
Sbjct: 13 LYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYILNFLRTSHLDLPE 72
Query: 342 TISEV 346
E+
Sbjct: 73 DFQEM 77
>gi|51036594 potassium channel tetramerisation domain containing 11
[Homo sapiens]
Length = 232
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/93 (38%), Positives = 45/93 (48%), Gaps = 9/93 (9%)
Query: 433 GQTLLIHGDGQMFRHILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQCEAYK 492
G I DG+ FRHILNFLRLG+L LP + E L E + Y I L +AL + EA
Sbjct: 21 GGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALLRAEADFYQIRPLLDALRELEA-- 78
Query: 493 SWTQEKESENEEAFSIRRLHVVTEGPGSLVEFS 525
S+ A + LH + LV FS
Sbjct: 79 -------SQGTPAPTAALLHADVDVSPRLVHFS 104
Score = 37.4 bits (85), Expect = 0.065
Identities = 20/61 (32%), Positives = 33/61 (54%)
Query: 204 IECECSEFRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPALTEAVRWYRMNMGGCSP 263
I+ + FR I+NFLR ++ LP + +L AE + +I L +A+R + G +P
Sbjct: 26 IDRDGKAFRHILNFLRLGRLDLPRGYGETALLRAEADFYQIRPLLDALRELEASQGTPAP 85
Query: 264 T 264
T
Sbjct: 86 T 86
Score = 35.8 bits (81), Expect = 0.19
Identities = 23/62 (37%), Positives = 29/62 (46%), Gaps = 1/62 (1%)
Query: 46 LTSSESQRLFIDRDGSTFRHVHYYLYTSKLSF-SSCAELNLLYEQALGLQLMPLLQTLDN 104
L S FIDRDG FRH+ +L +L E LL +A Q+ PLL L
Sbjct: 16 LNSQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALLRAEADFYQIRPLLDALRE 75
Query: 105 LK 106
L+
Sbjct: 76 LE 77
>gi|40807368 potassium channel regulator isoform 2 [Homo sapiens]
Length = 229
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/98 (28%), Positives = 51/98 (52%), Gaps = 6/98 (6%)
Query: 393 SPQQIIKVYVGSHWYATTLQTLLKYP-----ELLSNPQRVYWITYGQTLLIHGDGQMFRH 447
S Q+++ + VG + T T+ ++P +L + + + GQ + + DG +F
Sbjct: 2 SSQELVTLNVGGKIFTTRFSTIKQFPASRLARMLDGRDQEFKMVGGQ-IFVDRDGDLFSF 60
Query: 448 ILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEAL 485
IL+FLR +L LP+EF ++ +E Y + SL + L
Sbjct: 61 ILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLL 98
Score = 38.9 bits (89), Expect = 0.022
Identities = 39/141 (27%), Positives = 67/141 (47%), Gaps = 17/141 (12%)
Query: 10 SAEDLFHFNVGGWHFSVPRSKLSQFPDSLLWKEASALTSSESQ------RLFIDRDGSTF 63
S+++L NVGG F+ S + QFP S L A L + + ++F+DRDG F
Sbjct: 2 SSQELVTLNVGGKIFTTRFSTIKQFPASRL---ARMLDGRDQEFKMVGGQIFVDRDGDLF 58
Query: 64 RHVHYYLYTSKLSF-SSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRVRPA--DLP 120
+ +L T +L + ++ L +AL +L L+ L+ + L+ RPA ++
Sbjct: 59 SFILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLLN-----PYLLQPRPALVEVH 113
Query: 121 VAERASLNYWRTWKCISKPSE 141
R + ++R + SK E
Sbjct: 114 FLSRNTQAFFRVFGSCSKTIE 134
Score = 33.1 bits (74), Expect = 1.2
Identities = 16/44 (36%), Positives = 27/44 (61%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPALTEAVRWY 254
F FI++FLR+ ++LLP FS+ L+ E E+ +L + + Y
Sbjct: 58 FSFILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLLNPY 101
>gi|27734697 potassium channel regulator isoform 1 [Homo sapiens]
Length = 272
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/98 (28%), Positives = 51/98 (52%), Gaps = 6/98 (6%)
Query: 393 SPQQIIKVYVGSHWYATTLQTLLKYP-----ELLSNPQRVYWITYGQTLLIHGDGQMFRH 447
S Q+++ + VG + T T+ ++P +L + + + GQ + + DG +F
Sbjct: 2 SSQELVTLNVGGKIFTTRFSTIKQFPASRLARMLDGRDQEFKMVGGQ-IFVDRDGDLFSF 60
Query: 448 ILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEAL 485
IL+FLR +L LP+EF ++ +E Y + SL + L
Sbjct: 61 ILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLL 98
Score = 38.9 bits (89), Expect = 0.022
Identities = 39/141 (27%), Positives = 67/141 (47%), Gaps = 17/141 (12%)
Query: 10 SAEDLFHFNVGGWHFSVPRSKLSQFPDSLLWKEASALTSSESQ------RLFIDRDGSTF 63
S+++L NVGG F+ S + QFP S L A L + + ++F+DRDG F
Sbjct: 2 SSQELVTLNVGGKIFTTRFSTIKQFPASRL---ARMLDGRDQEFKMVGGQIFVDRDGDLF 58
Query: 64 RHVHYYLYTSKLSF-SSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRVRPA--DLP 120
+ +L T +L + ++ L +AL +L L+ L+ + L+ RPA ++
Sbjct: 59 SFILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLLN-----PYLLQPRPALVEVH 113
Query: 121 VAERASLNYWRTWKCISKPSE 141
R + ++R + SK E
Sbjct: 114 FLSRNTQAFFRVFGSCSKTIE 134
Score = 33.1 bits (74), Expect = 1.2
Identities = 16/44 (36%), Positives = 27/44 (61%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPALTEAVRWY 254
F FI++FLR+ ++LLP FS+ L+ E E+ +L + + Y
Sbjct: 58 FSFILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLLNPY 101
>gi|19923973 potassium channel tetramerisation domain containing
12 [Homo sapiens]
Length = 325
Score = 45.8 bits (107), Expect = 2e-04
Identities = 28/77 (36%), Positives = 37/77 (48%), Gaps = 10/77 (12%)
Query: 4 SGMAHESAE-----DLFHFNVGGWHFSVPRSKLSQFPDSLLWK-----EASALTSSESQR 53
SG + SAE D+ NVGG + R + PDSLLW+ + L R
Sbjct: 20 SGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGR 79
Query: 54 LFIDRDGSTFRHVHYYL 70
F+DRDG FR++ YL
Sbjct: 80 FFLDRDGFLFRYILDYL 96
Score = 40.8 bits (94), Expect = 0.006
Identities = 30/96 (31%), Positives = 47/96 (48%), Gaps = 8/96 (8%)
Query: 397 IIKVYVGSHWYATTLQTLLKYPELL-------SNPQRVYWITYGQTLLIHGDGQMFRHIL 449
I+++ VG Y T T++ P+ L PQ + + G+ L DG +FR+IL
Sbjct: 35 IVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDR-DGFLFRYIL 93
Query: 450 NFLRLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEAL 485
++LR +L LP F E +E E + +P L L
Sbjct: 94 DYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRL 129
Score = 35.0 bits (79), Expect = 0.32
Identities = 15/37 (40%), Positives = 24/37 (64%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPAL 247
FR+I+++LR +++LPD F L+ E E E+P L
Sbjct: 89 FRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPEL 125
>gi|55926200 potassium channel tetramerisation domain containing
16 [Homo sapiens]
Length = 428
Score = 44.7 bits (104), Expect = 4e-04
Identities = 27/76 (35%), Positives = 34/76 (44%), Gaps = 7/76 (9%)
Query: 2 EESGMAHESAEDLFHFNVGGWHFSVPRSKLSQFPDSLLWK-------EASALTSSESQRL 54
E+ S ++ NVGG + S L P SLLWK A+ L R
Sbjct: 14 EQGSAVPNSFPEVVELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTANDLAKDSKGRF 73
Query: 55 FIDRDGSTFRHVHYYL 70
FIDRDG FR++ YL
Sbjct: 74 FIDRDGFLFRYILDYL 89
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/118 (27%), Positives = 56/118 (47%), Gaps = 8/118 (6%)
Query: 396 QIIKVYVGSHWYATTLQTLLKYPELLS----NPQRVYWITYGQT----LLIHGDGQMFRH 447
+++++ VG Y T TL+ P L +P+R + I DG +FR+
Sbjct: 25 EVVELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTANDLAKDSKGRFFIDRDGFLFRY 84
Query: 448 ILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQCEAYKSWTQEKESENEEA 505
IL++LR ++ LP F E +E E + +P L + L E +S + S+ E+A
Sbjct: 85 ILDYLRDRQVVLPDHFPEKGRLKREAEYFQLPDLVKLLTPDEIKQSPDEFCHSDFEDA 142
Score = 35.8 bits (81), Expect = 0.19
Identities = 14/39 (35%), Positives = 27/39 (69%)
Query: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPALTE 249
FR+I+++LR ++++LPD+F L+ E E ++P L +
Sbjct: 82 FRYILDYLRDRQVVLPDHFPEKGRLKREAEYFQLPDLVK 120
>gi|223005950 SH3KBP1 binding protein 1 [Homo sapiens]
Length = 707
Score = 44.3 bits (103), Expect = 5e-04
Identities = 33/98 (33%), Positives = 48/98 (48%), Gaps = 4/98 (4%)
Query: 13 DLFHFNVGGWHFSVPRSKLSQFPDSLLWKEASALTSS---ESQRLFIDRDGSTFRHVHYY 69
++ H NVGG FS R L+ PDS S S+ E+ +FIDRD + F + +
Sbjct: 19 EVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDETGAIFIDRDPTVFAPILNF 78
Query: 70 LYTSKLSFSSCAELNLLYEQALGLQLMPLLQTLDNLKE 107
L T +L +LL+E A L PL++ L +E
Sbjct: 79 LRTKELDPRGVHGSSLLHE-AQFYGLTPLVRRLQLREE 115
>gi|45387953 potassium channel tetramerization domain containing
18 [Homo sapiens]
Length = 426
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/72 (36%), Positives = 36/72 (50%), Gaps = 3/72 (4%)
Query: 3 ESGMAHESAEDLFHFNVGGWHFSVPRSKLSQFPDSLLWKEASA---LTSSESQRLFIDRD 59
E A E D+ NVGG ++ R L +F DS+L S L + ES IDRD
Sbjct: 2 EGHKAEEEVLDVLRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDESGACVIDRD 61
Query: 60 GSTFRHVHYYLY 71
G F+++ YL+
Sbjct: 62 GRLFKYLLDYLH 73
>gi|46255026 potassium channel tetramerisation domain containing 3
[Homo sapiens]
Length = 815
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 4/93 (4%)
Query: 13 DLFHFNVGGWHFSVPRSKLSQFPDSLLWKEASALTSS---ESQRLFIDRDGSTFRHVHYY 69
++ NVGG FS R L PDS S S+ E+ +FIDRD + F + +
Sbjct: 18 EIVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNF 77
Query: 70 LYTSKLSFSSCAELNLLYEQALGLQLMPLLQTL 102
L T +L +N+L +A + PL++ L
Sbjct: 78 LRTKELDLRG-VSINVLRHEAEFYGITPLVRRL 109
>gi|23308551 potassium channel tetramerisation domain containing 7
[Homo sapiens]
Length = 289
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/105 (31%), Positives = 53/105 (50%), Gaps = 6/105 (5%)
Query: 18 NVGGWHFSVPRSKLSQFPDSLLWKEASA---LTSSESQRLFIDRDGSTFRHVHYYLYTSK 74
N+GG HF+ S L + D++L S + + R FIDRDG+ F V +L +
Sbjct: 56 NIGGAHFTTRLSTLRCYEDTMLAAMFSGRHYIPTDSEGRYFIDRDGTHFGDVLNFLRSGD 115
Query: 75 LSFSSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRVRPADL 119
L + +Y++A + PLL+ L+N++ K +VR A L
Sbjct: 116 L--PPRERVRAVYKEAQYYAIGPLLEQLENMQPLKGE-KVRQAFL 157
>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
member 2 [Homo sapiens]
Length = 630
Score = 41.2 bits (95), Expect = 0.005
Identities = 23/65 (35%), Positives = 32/65 (49%), Gaps = 1/65 (1%)
Query: 14 LFHFNVGGWHFSVPRSKLSQFPDSLLWK-EASALTSSESQRLFIDRDGSTFRHVHYYLYT 72
L NV G F + L ++PD+LL E E+Q+ F DRD FRH+ + T
Sbjct: 42 LIVLNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRT 101
Query: 73 SKLSF 77
KL +
Sbjct: 102 GKLHY 106
Score = 37.4 bits (85), Expect = 0.065
Identities = 23/66 (34%), Positives = 33/66 (50%), Gaps = 2/66 (3%)
Query: 397 IIKVYVGSHWYATTLQTLLKYPELL--SNPQRVYWITYGQTLLIHGDGQMFRHILNFLRL 454
+I + V + T TL +YP+ L S+ + ++ Q D +FRHILNF R
Sbjct: 42 LIVLNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRT 101
Query: 455 GKLFLP 460
GKL P
Sbjct: 102 GKLHYP 107
>gi|27436981 potassium voltage-gated channel, Shal-related
subfamily, member 1 [Homo sapiens]
Length = 647
Score = 40.4 bits (93), Expect = 0.008
Identities = 34/117 (29%), Positives = 56/117 (47%), Gaps = 10/117 (8%)
Query: 396 QIIKVYVGSHWYATTLQTLLKYPELL--SNPQRVYWITYGQTLLIHGDGQMFRHILNFLR 453
+++ V V + T TL +YP+ L S+ + ++ D MFRH+LNF R
Sbjct: 40 EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYR 99
Query: 454 LGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQC--EAY---KSWTQEKESENEEA 505
G+L P + + F +E+ Y + + E + C E Y K E+ +E+EEA
Sbjct: 100 TGRLHCPRQ-ECIQAFDEELAFYGL--VPELVGDCCLEEYRDRKKENAERLAEDEEA 153
Score = 39.3 bits (90), Expect = 0.017
Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 1/72 (1%)
Query: 5 GMAHESAEDLFHFNVGGWHFSVPRSKLSQFPDSLLWK-EASALTSSESQRLFIDRDGSTF 63
G+ +++ NV G F ++ L ++PD+LL E ++S F DRD F
Sbjct: 32 GVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDADSGEYFFDRDPDMF 91
Query: 64 RHVHYYLYTSKL 75
RHV + T +L
Sbjct: 92 RHVLNFYRTGRL 103
>gi|25952108 potassium voltage-gated channel delayed-rectifier
protein S3 [Homo sapiens]
Length = 491
Score = 40.0 bits (92), Expect = 0.010
Identities = 31/90 (34%), Positives = 44/90 (48%), Gaps = 18/90 (20%)
Query: 12 EDLFHFNVGGWHFSVPRSKLSQFPDSLLWK------EASALT-----SSESQRLFIDRDG 60
E+L + NVGG+ SV +S L +FP + L K E + L S + + DR+
Sbjct: 14 EELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNP 73
Query: 61 STFRHVHYYLYTSKLS-------FSSCAEL 83
S FR+V + YT KL FS C E+
Sbjct: 74 SLFRYVLNFYYTGKLHVMEELCVFSFCQEI 103
Score = 33.9 bits (76), Expect = 0.72
Identities = 24/72 (33%), Positives = 36/72 (50%), Gaps = 5/72 (6%)
Query: 444 MFRHILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQCEAYKSWTQEKESENE 503
+FR++LNF GKL + E + FCQE+E + I L Y QE++ EN
Sbjct: 75 LFRYVLNFYYTGKLHVMEELCVFS-FCQEIEYWGINELFIDSCCSNRY----QERKEENH 129
Query: 504 EAFSIRRLHVVT 515
E ++ H V+
Sbjct: 130 EKDWDQKSHDVS 141
>gi|142356950 potassium channel tetramerisation domain containing 14
[Homo sapiens]
Length = 255
Score = 39.7 bits (91), Expect = 0.013
Identities = 27/93 (29%), Positives = 47/93 (50%), Gaps = 6/93 (6%)
Query: 18 NVGGWHFSVPRSKLSQFPDSLLWKEASALTSSESQ---RLFIDRDGSTFRHVHYYLYTSK 74
NVGG + L +FP S L + S+L + + R FIDR + FR + YL T +
Sbjct: 38 NVGGEFHTTTLGTLRKFPGSKLAEMFSSLAKASTDAEGRFFIDRPSTYFRPILDYLRTGQ 97
Query: 75 LSFSSCAELNLLYEQALGLQLMPLLQTLDNLKE 107
+ E +Y +A ++ PL++ L+++ +
Sbjct: 98 VPTQHIPE---VYREAQFYEIKPLVKLLEDMPQ 127
Score = 33.5 bits (75), Expect = 0.94
Identities = 39/153 (25%), Positives = 68/153 (44%), Gaps = 20/153 (13%)
Query: 397 IIKVYVGSHWYATTLQTLLKYP-----ELLSNPQRVYWITYGQTLLIHGDGQMFRHILNF 451
++++ VG ++ TTL TL K+P E+ S+ + G+ I FR IL++
Sbjct: 34 VVELNVGGEFHTTTLGTLRKFPGSKLAEMFSSLAKASTDAEGR-FFIDRPSTYFRPILDY 92
Query: 452 LRLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQC-EAYKSWTQEKE--------SEN 502
LR G+ +P++ P +E + Y I L + L + + K+ SEN
Sbjct: 93 LRTGQ--VPTQ--HIPEVYREAQFYEIKPLVKLLEDMPQIFGEQVSRKQFLLQVPGYSEN 148
Query: 503 EEAF-SIRRLHVVTEGPGSLVEFSRDTKETTAY 534
E + R +T S++ +T+E AY
Sbjct: 149 LELMVRLARAEAITARKSSVLVCLVETEEQDAY 181
>gi|27436984 potassium voltage-gated channel, Shal-related
subfamily, member 3 isoform 1 [Homo sapiens]
Length = 655
Score = 38.9 bits (89), Expect = 0.022
Identities = 22/67 (32%), Positives = 34/67 (50%), Gaps = 1/67 (1%)
Query: 12 EDLFHFNVGGWHFSVPRSKLSQFPDSLLWK-EASALTSSESQRLFIDRDGSTFRHVHYYL 70
++L NV G F R+ L ++PD+LL E + +++ F DRD FR V +
Sbjct: 39 DELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFY 98
Query: 71 YTSKLSF 77
T KL +
Sbjct: 99 RTGKLHY 105
Score = 35.0 bits (79), Expect = 0.32
Identities = 32/113 (28%), Positives = 53/113 (46%), Gaps = 11/113 (9%)
Query: 396 QIIKVYVGSHWYATTLQTLLKYPELL--SNPQRVYWITYGQTLLIHGDGQMFRHILNFLR 453
++I + V + T TL +YP+ L S + ++ + D ++FR +LNF R
Sbjct: 40 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYR 99
Query: 454 LGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQC--EAYKSWTQEKESENEE 504
GKL P ++ + E+ Y I L E + C E YK +++ EN E
Sbjct: 100 TGKLHYP-RYECISAYDDELAFYGI--LPEIIGDCCYEEYK----DRKRENAE 145
>gi|27436986 potassium voltage-gated channel, Shal-related
subfamily, member 3 isoform 2 [Homo sapiens]
Length = 636
Score = 38.9 bits (89), Expect = 0.022
Identities = 22/67 (32%), Positives = 34/67 (50%), Gaps = 1/67 (1%)
Query: 12 EDLFHFNVGGWHFSVPRSKLSQFPDSLLWK-EASALTSSESQRLFIDRDGSTFRHVHYYL 70
++L NV G F R+ L ++PD+LL E + +++ F DRD FR V +
Sbjct: 39 DELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFY 98
Query: 71 YTSKLSF 77
T KL +
Sbjct: 99 RTGKLHY 105
Score = 35.0 bits (79), Expect = 0.32
Identities = 32/113 (28%), Positives = 53/113 (46%), Gaps = 11/113 (9%)
Query: 396 QIIKVYVGSHWYATTLQTLLKYPELL--SNPQRVYWITYGQTLLIHGDGQMFRHILNFLR 453
++I + V + T TL +YP+ L S + ++ + D ++FR +LNF R
Sbjct: 40 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYR 99
Query: 454 LGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQC--EAYKSWTQEKESENEE 504
GKL P ++ + E+ Y I L E + C E YK +++ EN E
Sbjct: 100 TGKLHYP-RYECISAYDDELAFYGI--LPEIIGDCCYEEYK----DRKRENAE 145
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 38.9 bits (89), Expect = 0.022
Identities = 62/226 (27%), Positives = 82/226 (36%), Gaps = 38/226 (16%)
Query: 548 WNKAKGNLVRSNQMDEAEQYTRP-IQVSLCRNAKRAGNPSTYSHCRGL--CTNPGHWGSH 604
W +A +L R Q D T P V +C + A + S R + C G G
Sbjct: 336 WGRAGASLARGPQPDR----THPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGER 391
Query: 605 PE-----SP-PKKKCTTINLTQKSETKDPPATPMQKLISLVREWDMVNCKQWEFQPLTAT 658
+ SP P ++ + QK E KD ++ +L RE + + P
Sbjct: 392 RKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARL 451
Query: 659 RSSPLEEATLQLPLGSEAASQPSTSAAWKAHSTASEKDPGPQAGAGAGAKDKGPEPTFKP 718
+S E + P S PSTS W H AS P P G G K P P
Sbjct: 452 SASTASELS---PKSKARPSSPSTS--W--HRPAS---PCPSPGPGHTLPPKPPSPRGTT 501
Query: 719 YLP-------------PKRAGTL-KDWSKQR-TKERESPAPEQPLP 749
P P AG K SK+R + E+ES AP P P
Sbjct: 502 ASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAP 547
>gi|13994353 potassium channel tetramerisation domain containing 10
[Homo sapiens]
Length = 313
Score = 38.5 bits (88), Expect = 0.029
Identities = 33/97 (34%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 398 IKVYVGSHWYATTLQTLLKYPELL----SNPQRVYWITYGQTLLIHGDGQMFRHILNFLR 453
+K+ VG Y TT+QTL K +L S V + G +LI G+ F ILN+LR
Sbjct: 34 VKLNVGGALYYTTMQTLTKQDTMLKAMFSGRMEVLTDSEGW-ILIDRCGKHFGTILNYLR 92
Query: 454 LGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQCEA 490
G + LP +E E + Y + L E +C+A
Sbjct: 93 DGAVPLPESRREIEELLAEAKYYLVQGLVE---ECQA 126
>gi|68303635 mutS homolog 3 [Homo sapiens]
Length = 1137
Score = 38.1 bits (87), Expect = 0.038
Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 8/95 (8%)
Query: 655 LTATRSSPLEEATLQLPLGSEAASQPSTSAAWKAHSTASEKDPGPQAGAGAGAK---DKG 711
L A+ S+P +A L S + + ++S+ A + DPG A A A A
Sbjct: 11 LAASSSAPARQAVLSRFFQSTGSLKSTSSST----GAADQVDPGAAAAAAAAAAAAPPAP 66
Query: 712 PEPTFKPYLPPKRAGTLKDWSKQRTKERESPAPEQ 746
P P F P LPP A T D K+R E + P ++
Sbjct: 67 PAPAFPPQLPPHIA-TEIDRRKKRPLENDGPVKKK 100
>gi|13376611 zinc finger protein 703 [Homo sapiens]
Length = 590
Score = 36.2 bits (82), Expect = 0.14
Identities = 43/150 (28%), Positives = 61/150 (40%), Gaps = 29/150 (19%)
Query: 627 PPATPMQKLISL-VREWDMVNCKQWEF------QPLTATRSSPLEEATLQLPLG--SEAA 677
PPA P+++ L +R M++ QPL++T SP+E + PL ++
Sbjct: 37 PPADPLRQANRLPIRVLKMLSAHTGHLLHPEYLQPLSSTPVSPIELDAKKSPLALLAQTC 96
Query: 678 SQ-------PST---SAAWKAHSTASEKDPGPQ----AGAGAGAKDKGPEP-----TFKP 718
SQ PS+ S A A+ +EKDPG A A A K G P +FKP
Sbjct: 97 SQIGKPDPPPSSKLNSVAAAANGLGAEKDPGRSAPGAASAAAALKQLGDSPAEDKSSFKP 156
Query: 719 YLPPKRAG-TLKDWSKQRTKERESPAPEQP 747
Y G + KD S + P
Sbjct: 157 YSKGSGGGDSRKDSGSSSVSSTSSSSSSSP 186
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,694,518
Number of Sequences: 37866
Number of extensions: 1899282
Number of successful extensions: 6502
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 6284
Number of HSP's gapped (non-prelim): 258
length of query: 926
length of database: 18,247,518
effective HSP length: 112
effective length of query: 814
effective length of database: 14,006,526
effective search space: 11401312164
effective search space used: 11401312164
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.