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Search of human proteins with 155030230
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
(671 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 1405 0.0
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 686 0.0
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 302 6e-82
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 294 2e-79
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 284 2e-76
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 284 2e-76
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 282 6e-76
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 281 1e-75
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 278 9e-75
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 278 9e-75
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 276 4e-74
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 276 4e-74
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 270 3e-72
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 257 2e-68
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 230 3e-60
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 230 3e-60
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 198 2e-50
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 140 4e-33
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 134 2e-31
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 111 2e-24
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 105 1e-22
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 105 1e-22
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 100 4e-21
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 85 2e-16
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 85 2e-16
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 83 7e-16
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 83 9e-16
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 83 9e-16
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 83 9e-16
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 79 1e-14
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 1405 bits (3636), Expect = 0.0
Identities = 671/671 (100%), Positives = 671/671 (100%)
Query: 1 MQGPPRSLRAGLSLDDFIPGHLQSHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCN 60
MQGPPRSLRAGLSLDDFIPGHLQSHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCN
Sbjct: 1 MQGPPRSLRAGLSLDDFIPGHLQSHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCN 60
Query: 61 GGYTPRRDASQHPDPAWYQTWPGPGSKPSASTKIPASQHTQNWSATWTKDSKRRDKRWVK 120
GGYTPRRDASQHPDPAWYQTWPGPGSKPSASTKIPASQHTQNWSATWTKDSKRRDKRWVK
Sbjct: 61 GGYTPRRDASQHPDPAWYQTWPGPGSKPSASTKIPASQHTQNWSATWTKDSKRRDKRWVK 120
Query: 121 YEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFEEPPRDPRHLGAQ 180
YEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFEEPPRDPRHLGAQ
Sbjct: 121 YEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFEEPPRDPRHLGAQ 180
Query: 181 QRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEE 240
QRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEE
Sbjct: 181 QRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEE 240
Query: 241 SWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSP 300
SWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSP
Sbjct: 241 SWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSP 300
Query: 301 KSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPS 360
KSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPS
Sbjct: 301 KSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPS 360
Query: 361 STRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEG 420
STRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEG
Sbjct: 361 STRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEG 420
Query: 421 EHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEH 480
EHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEH
Sbjct: 421 EHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEH 480
Query: 481 ICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSA 540
ICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSA
Sbjct: 481 ICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSA 540
Query: 541 RHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPL 600
RHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPL
Sbjct: 541 RHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPL 600
Query: 601 DLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKF 660
DLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKF
Sbjct: 601 DLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKF 660
Query: 661 GTFPGNYVAPV 671
GTFPGNYVAPV
Sbjct: 661 GTFPGNYVAPV 671
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 686 bits (1769), Expect = 0.0
Identities = 329/329 (100%), Positives = 329/329 (100%)
Query: 343 MADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQ 402
MADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQ
Sbjct: 1 MADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQ 60
Query: 403 KGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQ 462
KGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQ
Sbjct: 61 KGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQ 120
Query: 463 YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCD 522
YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCD
Sbjct: 121 YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCD 180
Query: 523 DGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQN 582
DGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQN
Sbjct: 181 DGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQN 240
Query: 583 LGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVM 642
LGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVM
Sbjct: 241 LGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVM 300
Query: 643 QQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
QQCDDGWFVGVSRRTQKFGTFPGNYVAPV
Sbjct: 301 QQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 302 bits (774), Expect = 6e-82
Identities = 224/661 (33%), Positives = 308/661 (46%), Gaps = 146/661 (22%)
Query: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLD---- 164
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+ D D
Sbjct: 291 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRDDDSDLYSP 347
Query: 165 -WTFEEPPRDPRHLGAQQ-------------RPAHRPGPATSSSGRS------WDHSEEL 204
++F E + P + + R A P PA SSS +S W+ ++
Sbjct: 348 RYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKK 407
Query: 205 ---------PRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRP 255
P+S + Y+PG S + E++D E W +F ELE G+ P
Sbjct: 408 VDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEID--LKNEPWYKFFSELEFGKPP 465
Query: 256 KKPLVD-DPGEKPSQPIEVLLERELA---ELSAELDK-------------------DLRA 292
K + D PG+ P E ++ E+S+E DL +
Sbjct: 466 PKKIWDYTPGDCSILPREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTS 525
Query: 293 IETRLPSPKSSPAPRRAPEQ-----RPPAGPASAWSSSYPH----APYLGSARSLSPHKM 343
+E KS P Q + P+ AS S P A YL S +
Sbjct: 526 LENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRH 585
Query: 344 ADGGSPFLGRRDFVYPSSTRDPSASNGGG----------------------SPARREEKK 381
D +R D +A G + R+ +
Sbjct: 586 DDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSE 645
Query: 382 RKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADE 441
+ AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E+LP E
Sbjct: 646 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 705
Query: 442 IPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGR 501
+P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGRI GT R
Sbjct: 706 KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSR 765
Query: 502 QGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQ 561
QGIFP +YV V + P +++P D +DL
Sbjct: 766 QGIFPITYVDVIKRP-------------------------------LVKNPVDYMDLPFS 794
Query: 562 TSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTP----- 616
+SP R+ T P+ +L GP L+ S + P Q TP
Sbjct: 795 SSPSRSA----TASPQLSHHSL-RAGPDLTES-------EKSYVQPQAQQRRVTPDRSQT 842
Query: 617 ------YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 670
Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P
Sbjct: 843 SQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 902
Query: 671 V 671
+
Sbjct: 903 L 903
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 294 bits (753), Expect = 2e-79
Identities = 218/648 (33%), Positives = 303/648 (46%), Gaps = 146/648 (22%)
Query: 98 QHTQNWSATWTKD-----SKRRDKRWV-----KYEGIGPVDESGMPIAPRSSVDRPRDWY 147
QH Q+ T + S +KR Y GIGPVDESG+P A R++VDRP+DWY
Sbjct: 85 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY 144
Query: 148 RRMFQQIHR-KMPDLQLD-----WTFEEPPRDPRHLGAQQRPAH---------------- 185
+ MF+QIH PD D +T+ +P + AQ PA
Sbjct: 145 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPY-SAQSHPAAKTQTYRPLSKSHSDNS 203
Query: 186 -----------------------RPGPATSSSGRSWDHSEEL---------PRSTFNYRP 213
RP +S+ WD + PRS F Y P
Sbjct: 204 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEP 263
Query: 214 GAFSTVLQ---PSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQP 270
G S++LQ P++++ ++N E W +F ELE G+ P K +D + S
Sbjct: 264 GK-SSILQHERPTDRINPDDIDLEN----EPWYKFFSELEFGRPPPKKPLDYVQDHSS-- 316
Query: 271 IEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGP------ASAWSS 324
V E L + S + R++E + S + R+ + P GP SA +
Sbjct: 317 -GVFNEASLYQSSID-----RSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRT 370
Query: 325 SYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARRE---EKK 381
S GS+ +L+ + S +D P S G +P R EK+
Sbjct: 371 SPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKE 430
Query: 382 RKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADE 441
+ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW EGEHHGR+GIFP +YVE L E
Sbjct: 431 KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPE 490
Query: 442 IPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTG 500
+P + PP Q E GEA+A+Y F D VELS RKG+ + L+++V++NWYEG+I GT
Sbjct: 491 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 550
Query: 501 RQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGG 560
RQGIFP SYV+V + + T A P P + S D I
Sbjct: 551 RQGIFPVSYVEVVK-----------------KNTKGAEDYPDPPIPHSYSS--DRIHSLS 591
Query: 561 QTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAM 620
P+R F+ +N+ G P++A+
Sbjct: 592 SNKPQRPVFTH---------ENIQGGG---------------------------EPFQAL 615
Query: 621 YQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
Y Y P+NEDELELRE D +DVM++CDDGWFVG SRRT+ FGTFPGNYV
Sbjct: 616 YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 663
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 511 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 563
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 284 bits (727), Expect = 2e-76
Identities = 200/567 (35%), Positives = 281/567 (49%), Gaps = 84/567 (14%)
Query: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFE 168
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+ D D
Sbjct: 328 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRDDDSDLY-- 382
Query: 169 EPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLR 228
PR+ ++ + P + S D + + RS P S++ S +
Sbjct: 383 ----SPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER--- 435
Query: 229 RREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLER--ELAELSAEL 286
N W E ++ + + PK PG+ E + E+S+E
Sbjct: 436 ------NDW--EPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSET 487
Query: 287 DKDLRAIETRLPSPKSSPAPR--RAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMA 344
+ + +S AP + E + P G R S
Sbjct: 488 PGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTK 547
Query: 345 DGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKG 404
D SP R F+ D S R ++K+ + AR KFDF+AQ+ KEL LQKG
Sbjct: 548 DSESP----RHFI----PADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKG 599
Query: 405 DIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYT 464
DIVYI+K++D+NW EGEHHGR+GIFP Y+E+LP E +P K QVLEYGEA+A++
Sbjct: 600 DIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFN 659
Query: 465 FKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDG 524
F GD +VE+SFRKGE I L+R+V+ENWYEGRI GT RQGIFP +YV V + P
Sbjct: 660 FNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP-------- 711
Query: 525 PQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLG 584
+++P D +DL +SP R+ + P Q+P+ Q + +
Sbjct: 712 -----------------------LVKNPVDYMDLPFSSSPSRSATASP-QQPQAQQRRV- 746
Query: 585 TPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQ 644
TP TSQ ++ Y+A+Y Y PQN+DELELR+GD VDVM++
Sbjct: 747 TP------------------DRSQTSQDLFS-YQALYSYIPQNDDELELRDGDIVDVMEK 787
Query: 645 CDDGWFVGVSRRTQKFGTFPGNYVAPV 671
CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 788 CDDGWFVGTSRRTKQFGTFPGNYVKPL 814
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 284 bits (727), Expect = 2e-76
Identities = 200/567 (35%), Positives = 281/567 (49%), Gaps = 84/567 (14%)
Query: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFE 168
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+ D D
Sbjct: 196 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRDDDSDLY-- 250
Query: 169 EPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLR 228
PR+ ++ + P + S D + + RS P S++ S +
Sbjct: 251 ----SPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER--- 303
Query: 229 RREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLER--ELAELSAEL 286
N W E ++ + + PK PG+ E + E+S+E
Sbjct: 304 ------NDW--EPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSET 355
Query: 287 DKDLRAIETRLPSPKSSPAPR--RAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMA 344
+ + +S AP + E + P G R S
Sbjct: 356 PGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTK 415
Query: 345 DGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKG 404
D SP R F+ D S R ++K+ + AR KFDF+AQ+ KEL LQKG
Sbjct: 416 DSESP----RHFI----PADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKG 467
Query: 405 DIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYT 464
DIVYI+K++D+NW EGEHHGR+GIFP Y+E+LP E +P K QVLEYGEA+A++
Sbjct: 468 DIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFN 527
Query: 465 FKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDG 524
F GD +VE+SFRKGE I L+R+V+ENWYEGRI GT RQGIFP +YV V + P
Sbjct: 528 FNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP-------- 579
Query: 525 PQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLG 584
+++P D +DL +SP R+ + P Q+P+ Q + +
Sbjct: 580 -----------------------LVKNPVDYMDLPFSSSPSRSATASP-QQPQAQQRRV- 614
Query: 585 TPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQ 644
TP TSQ ++ Y+A+Y Y PQN+DELELR+GD VDVM++
Sbjct: 615 TP------------------DRSQTSQDLFS-YQALYSYIPQNDDELELRDGDIVDVMEK 655
Query: 645 CDDGWFVGVSRRTQKFGTFPGNYVAPV 671
CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 656 CDDGWFVGTSRRTKQFGTFPGNYVKPL 682
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 282 bits (722), Expect = 6e-76
Identities = 203/612 (33%), Positives = 294/612 (48%), Gaps = 102/612 (16%)
Query: 98 QHTQNWSATWTKD-----SKRRDKRWV-----KYEGIGPVDESGMPIAPRSSVDRPRDWY 147
QH Q+ T + S +KR Y GIGPVDESG+P A R++VDRP+DWY
Sbjct: 108 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY 167
Query: 148 RRMFQQIHR-KMPDLQLD-----WTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHS 201
+ MF+QIH PD D +T+ +P + AQ PA + + S HS
Sbjct: 168 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPY-SAQSHPAAK---TQTYRPLSKSHS 223
Query: 202 EELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQ---RPKKP 258
+ P + + + P LR R++ + W+ ++++T + P+
Sbjct: 224 DNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSST--EKHDWDPPDRKVDTRKFRSEPRSI 281
Query: 259 LVDDPGEK---------PSQPIEVLLERELA---ELSAELDKDLRAIETRLPSPKSSPAP 306
+PG+ P +P++ + + E S R++E + S +
Sbjct: 282 FEYEPGKSSILQHERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDF 341
Query: 307 RRAPEQRPPAGPA------SAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPS 360
R+ + P GP SA +S GS+ +L+ + S +D P
Sbjct: 342 RKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR 401
Query: 361 STRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 417
S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW
Sbjct: 402 SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW 461
Query: 418 LEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFR 476
EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D VELS R
Sbjct: 462 YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR 521
Query: 477 KGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAA 536
KG+ + L+++V++NWYEG+I GT RQGIFP SYV+V + + T
Sbjct: 522 KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK-----------------KNTKG 564
Query: 537 ARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP 596
A P P + S D I P+R F+ +N+ G
Sbjct: 565 AEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG--------- 604
Query: 597 SHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRR 656
P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRR
Sbjct: 605 ------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRR 646
Query: 657 TQKFGTFPGNYV 668
T+ FGTFPGNYV
Sbjct: 647 TKFFGTFPGNYV 658
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 506 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 558
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 281 bits (719), Expect = 1e-75
Identities = 200/595 (33%), Positives = 287/595 (48%), Gaps = 102/595 (17%)
Query: 98 QHTQNWSATWTKD-----SKRRDKRWV-----KYEGIGPVDESGMPIAPRSSVDRPRDWY 147
QH Q+ T + S +KR Y GIGPVDESG+P A R++VDRP+DWY
Sbjct: 125 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY 184
Query: 148 RRMFQQIHR-KMPDLQLDWTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPR 206
+ MF+QIH P L PP + A + +RP S HS+ P
Sbjct: 185 KTMFKQIHMVHKPGLY------NPPYSAQSHPAAKTQTYRP--------LSKSHSDNSPN 230
Query: 207 STFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQ---RPKKPLVDDP 263
+ + + P LR R++ + W+ ++++T + P+ +P
Sbjct: 231 AFKDASSPVPPPHVPPPVPPLRPRDRSST--EKHDWDPPDRKVDTRKFRSEPRSIFEYEP 288
Query: 264 GEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPA---- 319
G+ + ER + + +D R++E + S + R+ + P GP
Sbjct: 289 GKSSI----LQHERPASLYQSSID---RSLERPMSSASMASDFRKRRKSEPAVGPPRGLG 341
Query: 320 --SAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARR 377
SA +S GS+ +L+ + S +D P S G +P R
Sbjct: 342 DQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRER 401
Query: 378 E---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYV 434
EK++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW EGEHHGR+GIFP +YV
Sbjct: 402 RGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYV 461
Query: 435 EVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYE 493
E L E +P + PP Q E GEA+A+Y F D VELS RKG+ + L+++V++NWYE
Sbjct: 462 EKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYE 521
Query: 494 GRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPA 553
G+I GT RQGIFP SYV+V + + T A P P + S
Sbjct: 522 GKIPGTNRQGIFPVSYVEVVK-----------------KNTKGAEDYPDPPIPHSYSS-- 562
Query: 554 DPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIH 613
D I P+R F+ +N+ G
Sbjct: 563 DRIHSLSSNKPQRPVFTH---------ENIQGGG-------------------------- 587
Query: 614 WTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRRT+ FGTFPGNYV
Sbjct: 588 -EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 641
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 489 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 541
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 278 bits (712), Expect = 9e-75
Identities = 203/606 (33%), Positives = 288/606 (47%), Gaps = 106/606 (17%)
Query: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFE 168
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+ D D
Sbjct: 196 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRDDDSDLY-- 250
Query: 169 EPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQ------- 221
PR+ ++ + P + S D + + RS P S++
Sbjct: 251 ----SPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDW 306
Query: 222 --PSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLEREL 279
P +V R+ + + E + + T ++ + P E S+ +
Sbjct: 307 EPPDKKVDTRKYRAEPKSIYE-YQPGKSSVLTNEKMSSAISPTP-EISSETPGYIYSSNF 364
Query: 280 AELSAELDK---DLRAIETRLPSPKSSPAPRRAPEQ-----RPPAGPASAWSSSYPH--- 328
+ E D DL ++E KS P Q + P+ AS S P
Sbjct: 365 HAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFI 424
Query: 329 -APYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGG--------------- 372
A YL S + D +R D +A G
Sbjct: 425 PADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFG 484
Query: 373 -------SPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGR 425
+ R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR
Sbjct: 485 DLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 544
Query: 426 LGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIR 485
+GIFP Y+E+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R
Sbjct: 545 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 604
Query: 486 KVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSS 545
+V+ENWYEGRI GT RQGIFP +YV V + P
Sbjct: 605 QVDENWYEGRIPGTSRQGIFPITYVDVIKRP----------------------------- 635
Query: 546 PSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTS 605
+++P D +DL +SP R+ + P Q+P+ Q + + TP
Sbjct: 636 --LVKNPVDYMDLPFSSSPSRSATASP-QQPQAQQRRV-TP------------------D 673
Query: 606 SPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPG 665
TSQ ++ Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPG
Sbjct: 674 RSQTSQDLFS-YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPG 732
Query: 666 NYVAPV 671
NYV P+
Sbjct: 733 NYVKPL 738
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 278 bits (712), Expect = 9e-75
Identities = 203/606 (33%), Positives = 288/606 (47%), Gaps = 106/606 (17%)
Query: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFE 168
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+ D D
Sbjct: 237 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRDDDSDLY-- 291
Query: 169 EPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQ------- 221
PR+ ++ + P + S D + + RS P S++
Sbjct: 292 ----SPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDW 347
Query: 222 --PSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLEREL 279
P +V R+ + + E + + T ++ + P E S+ +
Sbjct: 348 EPPDKKVDTRKYRAEPKSIYE-YQPGKSSVLTNEKMSSAISPTP-EISSETPGYIYSSNF 405
Query: 280 AELSAELDK---DLRAIETRLPSPKSSPAPRRAPEQ-----RPPAGPASAWSSSYPH--- 328
+ E D DL ++E KS P Q + P+ AS S P
Sbjct: 406 HAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFI 465
Query: 329 -APYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGG--------------- 372
A YL S + D +R D +A G
Sbjct: 466 PADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFG 525
Query: 373 -------SPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGR 425
+ R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR
Sbjct: 526 DLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 585
Query: 426 LGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIR 485
+GIFP Y+E+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R
Sbjct: 586 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 645
Query: 486 KVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSS 545
+V+ENWYEGRI GT RQGIFP +YV V + P
Sbjct: 646 QVDENWYEGRIPGTSRQGIFPITYVDVIKRP----------------------------- 676
Query: 546 PSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTS 605
+++P D +DL +SP R+ + P Q+P+ Q + + TP
Sbjct: 677 --LVKNPVDYMDLPFSSSPSRSATASP-QQPQAQQRRV-TP------------------D 714
Query: 606 SPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPG 665
TSQ ++ Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPG
Sbjct: 715 RSQTSQDLFS-YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPG 773
Query: 666 NYVAPV 671
NYV P+
Sbjct: 774 NYVKPL 779
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 276 bits (706), Expect = 4e-74
Identities = 211/661 (31%), Positives = 292/661 (44%), Gaps = 147/661 (22%)
Query: 98 QHTQNWSATWTKD-----SKRRDKRWV-----KYEGIGPVDESGMPIAPRSSVDRPRDWY 147
QH Q+ T + S +KR Y GIGPVDESG+P A R++VDRP+DWY
Sbjct: 218 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY 277
Query: 148 RRMFQQIHR-KMPDLQLD-----WTFEEPPRDPRHLGAQQRPAH---------------- 185
+ MF+QIH PD D +T+ +P + AQ PA
Sbjct: 278 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPY-SAQSHPAAKTQTYRPLSKSHSDNS 336
Query: 186 -----------------------RPGPATSSSGRSWDHSEEL---------PRSTFNYRP 213
RP +S+ WD + PRS F Y P
Sbjct: 337 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEP 396
Query: 214 GAFSTVLQ-------PSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDD---- 262
G S++LQ P+ RE + + R P
Sbjct: 397 GK-SSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPA 455
Query: 263 --PGEKPSQPIEVLLERELA---ELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAG 317
P P +P++ + + E S R++E + S + R+ + P G
Sbjct: 456 LSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVG 515
Query: 318 PA------SAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGG 371
P SA +S GS+ +L+ + S +D P S G
Sbjct: 516 PPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGR 575
Query: 372 GSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGI 428
+P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW EGEHHGR+GI
Sbjct: 576 SAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGI 635
Query: 429 FPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKV 487
FP +YVE L E +P + PP Q E GEA+A+Y F D VELS RKG+ + L+++V
Sbjct: 636 FPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRV 695
Query: 488 NENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS 547
++NWYEG+I GT RQGIFP SYV+V + + T A P P
Sbjct: 696 DQNWYEGKIPGTNRQGIFPVSYVEVVK-----------------KNTKGAEDYPDPPIPH 738
Query: 548 ALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSP 607
+ S D I P+R F+ +N+ G
Sbjct: 739 SYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-------------------- 767
Query: 608 NTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNY 667
P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRRT+ FGTFPGNY
Sbjct: 768 -------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNY 820
Query: 668 V 668
V
Sbjct: 821 V 821
Score = 69.7 bits (169), Expect = 8e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 358 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 417
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 640 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 699
Query: 418 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 452
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 700 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 759
Query: 453 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 508
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 760 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 819
Query: 509 YVQ 511
YV+
Sbjct: 820 YVK 822
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 669 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 721
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 276 bits (706), Expect = 4e-74
Identities = 211/661 (31%), Positives = 292/661 (44%), Gaps = 147/661 (22%)
Query: 98 QHTQNWSATWTKD-----SKRRDKRWV-----KYEGIGPVDESGMPIAPRSSVDRPRDWY 147
QH Q+ T + S +KR Y GIGPVDESG+P A R++VDRP+DWY
Sbjct: 125 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY 184
Query: 148 RRMFQQIHR-KMPDLQLD-----WTFEEPPRDPRHLGAQQRPAH---------------- 185
+ MF+QIH PD D +T+ +P + AQ PA
Sbjct: 185 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPY-SAQSHPAAKTQTYRPLSKSHSDNS 243
Query: 186 -----------------------RPGPATSSSGRSWDHSEEL---------PRSTFNYRP 213
RP +S+ WD + PRS F Y P
Sbjct: 244 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEP 303
Query: 214 GAFSTVLQ-------PSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDD---- 262
G S++LQ P+ RE + + R P
Sbjct: 304 GK-SSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPA 362
Query: 263 --PGEKPSQPIEVLLERELA---ELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAG 317
P P +P++ + + E S R++E + S + R+ + P G
Sbjct: 363 LSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVG 422
Query: 318 PA------SAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGG 371
P SA +S GS+ +L+ + S +D P S G
Sbjct: 423 PPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGR 482
Query: 372 GSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGI 428
+P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW EGEHHGR+GI
Sbjct: 483 SAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGI 542
Query: 429 FPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKV 487
FP +YVE L E +P + PP Q E GEA+A+Y F D VELS RKG+ + L+++V
Sbjct: 543 FPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRV 602
Query: 488 NENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS 547
++NWYEG+I GT RQGIFP SYV+V + + T A P P
Sbjct: 603 DQNWYEGKIPGTNRQGIFPVSYVEVVK-----------------KNTKGAEDYPDPPIPH 645
Query: 548 ALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSP 607
+ S D I P+R F+ +N+ G
Sbjct: 646 SYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-------------------- 674
Query: 608 NTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNY 667
P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRRT+ FGTFPGNY
Sbjct: 675 -------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNY 727
Query: 668 V 668
V
Sbjct: 728 V 728
Score = 69.7 bits (169), Expect = 8e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 358 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 417
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 547 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 606
Query: 418 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 452
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 607 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 666
Query: 453 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 508
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 667 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 726
Query: 509 YVQ 511
YV+
Sbjct: 727 YVK 729
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 576 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 628
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 270 bits (690), Expect = 3e-72
Identities = 153/339 (45%), Positives = 197/339 (58%), Gaps = 43/339 (12%)
Query: 376 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 435
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 811 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 870
Query: 436 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 495
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 871 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 930
Query: 496 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLP--TSPRLTAAA---------------- 537
I GT RQGIFP +YV V + P ++ D LP +SP +A A
Sbjct: 931 IPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKA 990
Query: 538 ---RSARHPSSPS-ALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHS 593
R P P + +S P D+ S + T E + LG+ P
Sbjct: 991 ERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAE 1050
Query: 594 RGPSH----------PLDLGTSSPNTSQIHWTP-----------YRAMYQYRPQNEDELE 632
+ H G+ P Q TP Y+A+Y Y PQN+DELE
Sbjct: 1051 QTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELE 1110
Query: 633 LREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
LR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 1111 LRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
Score = 75.1 bits (183), Expect = 2e-13
Identities = 96/377 (25%), Positives = 157/377 (41%), Gaps = 65/377 (17%)
Query: 181 QRPAHRPGPATSSSGRS------WDHSEEL---------PRSTFNYRPGAFSTVLQPSNQ 225
+R A P PA SSS +S W+ ++ P+S + Y+PG S +
Sbjct: 515 KRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMS 574
Query: 226 VLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVD-DPGE---KPSQPIEVLLERELAE 281
E++D E W +F ELE G+ P K + D PG+ P + + L+++L+
Sbjct: 575 RDISPEEID--LKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSL 632
Query: 282 LSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAG---PASAWSSSYPHA--------- 329
EL+ DL +ET +P ++ A P P +SS++ HA
Sbjct: 633 CQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNF-HAVKRESDGAP 691
Query: 330 ---PYLGSARSLSPHKMADGGSPFLGRRDFVYPS---STRDPSASNGGGSPARREEKKRK 383
L + R + + G P G PS ST+D S S PA E +
Sbjct: 692 GDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKD-SESPRHFIPADYLESTEE 750
Query: 384 AARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPAN--------YVE 435
R + D KE L D + +E ++ + H G+ P + + +
Sbjct: 751 FIRRRHD-----DKEKLL--ADQRRLKREQEEADIAARRH--TGVIPTHHQFITNERFGD 801
Query: 436 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 495
+L D+ K E A A++ FK EL +KG+ + + +++++NWYEG
Sbjct: 802 LLNIDDTAK-----RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 856
Query: 496 ITGTGRQGIFPASYVQV 512
GR GIFP +Y+++
Sbjct: 857 --HHGRVGIFPRTYIEL 871
Score = 38.9 bits (89), Expect = 0.016
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 600 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 659
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 803 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 860
Query: 660 FGTFPGNYV 668
G FP Y+
Sbjct: 861 VGIFPRTYI 869
Score = 36.6 bits (83), Expect = 0.077
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 14/85 (16%)
Query: 367 ASNGGGSPARREEKKR------KAARLKFDFQA------QSPKELTLQKGDIVYIHKEVD 414
A+ GGS + +++R + ++ F +QA Q+ EL L+ GDIV + ++ D
Sbjct: 1065 AARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 1124
Query: 415 KNWLEG--EHHGRLGIFPANYVEVL 437
W G + G FP NYV+ L
Sbjct: 1125 DGWFVGTSRRTKQFGTFPGNYVKPL 1149
Score = 36.2 bits (82), Expect = 0.10
Identities = 23/68 (33%), Positives = 35/68 (51%), Gaps = 8/68 (11%)
Query: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFE 168
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+ D T E
Sbjct: 360 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRD-----TPE 411
Query: 169 EPPRDPRH 176
E P P +
Sbjct: 412 ENPYFPTY 419
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 257 bits (657), Expect = 2e-68
Identities = 183/552 (33%), Positives = 268/552 (48%), Gaps = 87/552 (15%)
Query: 136 PRSSVDRPRDWYRRMFQQIHR-KMPDLQLD-----WTFEEPPRDPRHLGAQQRPAHRPGP 189
P +VDRP+DWY+ MF+QIH PD D +T+ +P + AQ PA +
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPY-SAQSHPAAK--- 61
Query: 190 ATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQEL 249
+ S HS+ P + + + P LR R++ + W+ +++
Sbjct: 62 TQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSST--EKHDWDPPDRKV 119
Query: 250 ETGQ---RPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAP 306
+T + P+ +PG+ + ER + + +D R++E + S +
Sbjct: 120 DTRKFRSEPRSIFEYEPGKSSI----LQHERPASLYQSSID---RSLERPMSSASMASDF 172
Query: 307 RRAPEQRPPAGPA------SAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPS 360
R+ + P GP SA +S GS+ +L+ + S +D P
Sbjct: 173 RKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR 232
Query: 361 STRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 417
S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW
Sbjct: 233 SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW 292
Query: 418 LEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFR 476
EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D VELS R
Sbjct: 293 YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR 352
Query: 477 KGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAA 536
KG+ + L+++V++NWYEG+I GT RQGIFP SYV+V + + T
Sbjct: 353 KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK-----------------KNTKG 395
Query: 537 ARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP 596
A P P + S D I P+R F+ +N+ G
Sbjct: 396 AEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG--------- 435
Query: 597 SHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRR 656
P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRR
Sbjct: 436 ------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRR 477
Query: 657 TQKFGTFPGNYV 668
T+ FGTFPGNYV
Sbjct: 478 TKFFGTFPGNYV 489
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 337 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 389
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 230 bits (587), Expect = 3e-60
Identities = 147/410 (35%), Positives = 205/410 (50%), Gaps = 65/410 (15%)
Query: 265 EKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSS 324
++ S P +L R ++EL ++ + ++ SP P P+ P
Sbjct: 651 KRGSLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCG 710
Query: 325 SYPHAPYLGSARSL--SPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARRE---E 379
P + + S H GG+ +D P S G +P R E
Sbjct: 711 RMPRSASFQDVDTANSSCHHQDRGGA----LQDRESPRSYSSTLTDMGRSAPRERRGTPE 766
Query: 380 KKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPA 439
K++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW EGEHHGR+GIFP +YVE L
Sbjct: 767 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 826
Query: 440 DEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITG 498
E +P + PP Q E GEA+A+Y F D VELS RKG+ + L+++V++NWYEG+I G
Sbjct: 827 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 886
Query: 499 TGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDL 558
T RQGIFP SYV+V + + T A P P + S D I
Sbjct: 887 TNRQGIFPVSYVEVVK-----------------KNTKGAEDYPDPPIPHSYSS--DRIHS 927
Query: 559 GGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYR 618
P+R F+ +N+ G P++
Sbjct: 928 LSSNKPQRPVFTH---------ENIQGGG---------------------------EPFQ 951
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRRT+ FGTFPGNYV
Sbjct: 952 ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1001
Score = 69.7 bits (169), Expect = 8e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 358 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 417
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 820 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 879
Query: 418 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 452
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 880 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 939
Query: 453 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 508
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 940 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 999
Query: 509 YVQ 511
YV+
Sbjct: 1000 YVK 1002
Score = 43.1 bits (100), Expect = 8e-04
Identities = 56/240 (23%), Positives = 93/240 (38%), Gaps = 36/240 (15%)
Query: 136 PRSSVDRPRDWYRRMFQQIHR-KMPDLQLDWTFEEPPRDPRHLGAQQRPAHRPGPATSSS 194
P +VDRP+DWY+ MF+QIH P L PP + A + +RP
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPGLY------NPPYSAQSHPAAKTQTYRP------- 52
Query: 195 GRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQ- 253
S HS+ P + + + P LR R++ + W+ ++++T +
Sbjct: 53 -LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSST--EKHDWDPPDRKVDTRKF 109
Query: 254 --RPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPE 311
P+ +PG+ + ER + + +D R++E + S + R+ +
Sbjct: 110 RSEPRSIFEYEPGKSSI----LQHERPASLYQSSID---RSLERPMSSASMASDFRKRRK 162
Query: 312 QRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGG 371
P GP SA SP ++ GS + F SS PS + GG
Sbjct: 163 SEPAVGPPRGLGDQ--------SASRTSPGRVDLPGSSTTLTKSFT-SSSPSSPSRAKGG 213
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 849 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 901
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 230 bits (587), Expect = 3e-60
Identities = 147/410 (35%), Positives = 205/410 (50%), Gaps = 65/410 (15%)
Query: 265 EKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSS 324
++ S P +L R ++EL ++ + ++ SP P P+ P
Sbjct: 747 KRGSLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCG 806
Query: 325 SYPHAPYLGSARSL--SPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARRE---E 379
P + + S H GG+ +D P S G +P R E
Sbjct: 807 RMPRSASFQDVDTANSSCHHQDRGGA----LQDRESPRSYSSTLTDMGRSAPRERRGTPE 862
Query: 380 KKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPA 439
K++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW EGEHHGR+GIFP +YVE L
Sbjct: 863 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 922
Query: 440 DEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITG 498
E +P + PP Q E GEA+A+Y F D VELS RKG+ + L+++V++NWYEG+I G
Sbjct: 923 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 982
Query: 499 TGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDL 558
T RQGIFP SYV+V + + T A P P + S D I
Sbjct: 983 TNRQGIFPVSYVEVVK-----------------KNTKGAEDYPDPPIPHSYSS--DRIHS 1023
Query: 559 GGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYR 618
P+R F+ +N+ G P++
Sbjct: 1024 LSSNKPQRPVFTH---------ENIQGGG---------------------------EPFQ 1047
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRRT+ FGTFPGNYV
Sbjct: 1048 ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1097
Score = 69.7 bits (169), Expect = 8e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 358 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 417
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 916 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 975
Query: 418 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 452
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 976 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 1035
Query: 453 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 508
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 1036 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 1095
Query: 509 YVQ 511
YV+
Sbjct: 1096 YVK 1098
Score = 68.6 bits (166), Expect = 2e-11
Identities = 77/293 (26%), Positives = 122/293 (41%), Gaps = 41/293 (13%)
Query: 98 QHTQNWSATWTKD-----SKRRDKRWV-----KYEGIGPVDESGMPIAPRSSVDRPRDWY 147
QH Q+ T + S +KR Y GIGPVDESG+P A R++VDRP+DWY
Sbjct: 39 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY 98
Query: 148 RRMFQQIHR-KMPDLQLD-----WTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHS 201
+ MF+QIH PD D +T+ +P + AQ PA + + S HS
Sbjct: 99 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPY-SAQSHPAAK---TQTYRPLSKSHS 154
Query: 202 EELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQ---RPKKP 258
+ P + + + P LR R++ + W+ ++++T + P+
Sbjct: 155 DNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSST--EKHDWDPPDRKVDTRKFRSEPRSI 212
Query: 259 LVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGP 318
+PG+ + ER + + +D R++E + S + R+ + P GP
Sbjct: 213 FEYEPGKSSI----LQHERPASLYQSSID---RSLERPMSSASMASDFRKRRKSEPAVGP 265
Query: 319 ASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGG 371
SA SP ++ GS + F SS PS + GG
Sbjct: 266 PRGLGDQ--------SASRTSPGRVDLPGSSTTLTKSFT-SSSPSSPSRAKGG 309
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 945 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 997
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 198 bits (503), Expect = 2e-50
Identities = 113/247 (45%), Positives = 146/247 (59%), Gaps = 20/247 (8%)
Query: 376 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 435
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 789 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 848
Query: 436 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 495
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 849 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 908
Query: 496 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPA-- 553
I GT RQGIFP +YV V + P ++ D LP S + +A ++ SS S L +PA
Sbjct: 909 IPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPAPS 968
Query: 554 ------------------DPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRG 595
+ I L RR+ P P P+ T ALS
Sbjct: 969 SLPHSRRALSPEMHAVTSEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDHLALSPRAS 1028
Query: 596 PSHPLDL 602
PS L L
Sbjct: 1029 PSLSLSL 1035
Score = 99.0 bits (245), Expect = 1e-20
Identities = 46/80 (57%), Positives = 56/80 (70%), Gaps = 11/80 (13%)
Query: 603 GTSSPNTSQIHWTP-----------YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFV 651
G+ P Q TP Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFV
Sbjct: 1211 GSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 1270
Query: 652 GVSRRTQKFGTFPGNYVAPV 671
G SRRT++FGTFPGNYV P+
Sbjct: 1271 GTSRRTKQFGTFPGNYVKPL 1290
Score = 75.1 bits (183), Expect = 2e-13
Identities = 96/377 (25%), Positives = 157/377 (41%), Gaps = 65/377 (17%)
Query: 181 QRPAHRPGPATSSSGRS------WDHSEEL---------PRSTFNYRPGAFSTVLQPSNQ 225
+R A P PA SSS +S W+ ++ P+S + Y+PG S +
Sbjct: 493 KRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMS 552
Query: 226 VLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVD-DPGE---KPSQPIEVLLERELAE 281
E++D E W +F ELE G+ P K + D PG+ P + + L+++L+
Sbjct: 553 RDISPEEID--LKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSL 610
Query: 282 LSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAG---PASAWSSSYPHA--------- 329
EL+ DL +ET +P ++ A P P +SS++ HA
Sbjct: 611 CQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNF-HAVKRESDGAP 669
Query: 330 ---PYLGSARSLSPHKMADGGSPFLGRRDFVYPS---STRDPSASNGGGSPARREEKKRK 383
L + R + + G P G PS ST+D S S PA E +
Sbjct: 670 GDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKD-SESPRHFIPADYLESTEE 728
Query: 384 AARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPAN--------YVE 435
R + D KE L D + +E ++ + H G+ P + + +
Sbjct: 729 FIRRRHD-----DKEKLL--ADQRRLKREQEEADIAARRH--TGVIPTHHQFITNERFGD 779
Query: 436 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 495
+L D+ K E A A++ FK EL +KG+ + + +++++NWYEG
Sbjct: 780 LLNIDDTAK-----RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 834
Query: 496 ITGTGRQGIFPASYVQV 512
GR GIFP +Y+++
Sbjct: 835 --HHGRVGIFPRTYIEL 849
Score = 38.9 bits (89), Expect = 0.016
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 600 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 659
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 781 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 838
Query: 660 FGTFPGNYV 668
G FP Y+
Sbjct: 839 VGIFPRTYI 847
Score = 38.5 bits (88), Expect = 0.020
Identities = 15/50 (30%), Positives = 28/50 (56%)
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
A + + + E+ R+G+R+ +++Q D+ W+ G T + G FP YV
Sbjct: 874 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 923
Score = 38.1 bits (87), Expect = 0.027
Identities = 35/120 (29%), Positives = 54/120 (45%), Gaps = 30/120 (25%)
Query: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHR------------ 156
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+
Sbjct: 360 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRDTPEENPYF 416
Query: 157 ---KMPDL-QLDWTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEEL--PRSTFN 210
K P+L ++ T EE D + Q PA P P +S D +L PR +F+
Sbjct: 417 PTYKFPELPEIQQTSEE---DNPYTPTYQFPASTPSP------KSEDDDSDLYSPRYSFS 467
Score = 36.6 bits (83), Expect = 0.077
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 14/85 (16%)
Query: 367 ASNGGGSPARREEKKR------KAARLKFDFQA------QSPKELTLQKGDIVYIHKEVD 414
A+ GGS + +++R + ++ F +QA Q+ EL L+ GDIV + ++ D
Sbjct: 1206 AARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 1265
Query: 415 KNWLEG--EHHGRLGIFPANYVEVL 437
W G + G FP NYV+ L
Sbjct: 1266 DGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 35.4 bits (80), Expect = 0.17
Identities = 70/268 (26%), Positives = 103/268 (38%), Gaps = 58/268 (21%)
Query: 299 SPKSSPA-----PRRAPEQRP-PAGPASAWSSSYPHAPY-LGSARSLSPHKMADGG--SP 349
SP++SP+ P + RP P AS + PH Y L S H DGG +P
Sbjct: 1024 SPRASPSLSLSLPHLSWSDRPTPRSVASPLALPSPHKTYSLAPTSQASLHMNGDGGVHTP 1083
Query: 350 F------------LGRRDFVYPSSTRDPSASNGGGSPARRE--EKKRKAARLKFDFQAQS 395
LG D V S D +S P R E + +RKA R +
Sbjct: 1084 SSGIHQDSFLQLPLGSSDSVI-SQLSDAFSSQSKRQPWREESGQYERKAERGAGERGPGG 1142
Query: 396 PK---ELTLQKGDIVYI----HKEVDKNWLEGEHHGR-LG-IFPANYVEVLP-------- 438
PK + L+ D+V + D N E G+ LG FP + E
Sbjct: 1143 PKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQA 1202
Query: 439 --------ADEIPK-------PIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICL 483
+ P+ P + T Q L +A+ Y + D E+EL R G+ + +
Sbjct: 1203 GRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELEL--RDGDIVDV 1260
Query: 484 IRKVNENWYEGRITGTGRQGIFPASYVQ 511
+ K ++ W+ G T + G FP +YV+
Sbjct: 1261 MEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 140 bits (353), Expect = 4e-33
Identities = 124/411 (30%), Positives = 179/411 (43%), Gaps = 114/411 (27%)
Query: 361 STRDPSASNGGG-------SPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEV 413
S++D +S GG SP R + A+ ++++ + P +L KGDI+ + ++V
Sbjct: 108 SSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQV 167
Query: 414 DKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFK-GDLEVE 472
D+NW GE +G G FP N+V+++ P P PP + A Y F+ D E +
Sbjct: 168 DENWYHGEVNGIHGFFPTNFVQIIK----PLPQPPP--------QCKALYDFEVKDKEAD 215
Query: 473 ---LSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLP- 528
L F K + + +IR+V+ENW EG + + GIFP SYV+ + + + D P +P
Sbjct: 216 KDCLPFAKDDVLTVIRRVDENWAEGML--ADKIGIFPISYVEFNSAAKQLIEWDKPPVPG 273
Query: 529 --------------TSPR----------------LTAAARSA-----RHPS--SPSALRS 551
T+P+ LT A +S+ RH SP L S
Sbjct: 274 VDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLIS 333
Query: 552 PADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPS--HPLD------LG 603
++P + S P+Q T + TP P+ + GPS P D LG
Sbjct: 334 SSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALG 393
Query: 604 TSSP------------------------------------NTSQI-HWTP------YRAM 620
T +P +T QI H P Y A+
Sbjct: 394 TLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAI 453
Query: 621 YQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
Y Y P+ EDELELR+G+ V ++C DGWF G S T K G FPGNYVAPV
Sbjct: 454 YPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
Score = 57.8 bits (138), Expect = 3e-08
Identities = 35/91 (38%), Positives = 47/91 (51%), Gaps = 16/91 (17%)
Query: 578 PQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGD 637
P Q + GP L+ SR P + H R + Y PQ+E ELEL+EGD
Sbjct: 811 PPRQACSSLGPVLNESR------------PVVCERH----RVVVSYPPQSEAELELKEGD 854
Query: 638 RVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
V V ++ +DGWF G +R K G FPG++V
Sbjct: 855 IVFVHKKREDGWFKGTLQRNGKTGLFPGSFV 885
Score = 48.9 bits (115), Expect = 2e-05
Identities = 46/178 (25%), Positives = 72/178 (40%), Gaps = 29/178 (16%)
Query: 287 DKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSP----HK 342
DKD + + L S + +R P PPA P P G+ P H
Sbjct: 709 DKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHG 768
Query: 343 MA-----DGGSPF--------LGRRDFVYPSSTRD--------PSASNGGGSPARREEKK 381
A DG P L + F +S+ D P + P E +
Sbjct: 769 RAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRP 828
Query: 382 R--KAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEG--EHHGRLGIFPANYVE 435
+ R+ + QS EL L++GDIV++HK+ + W +G + +G+ G+FP ++VE
Sbjct: 829 VVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 47.8 bits (112), Expect = 3e-05
Identities = 81/366 (22%), Positives = 124/366 (33%), Gaps = 57/366 (15%)
Query: 268 SQPIEVLLERELAELSAELDKDLRAIETRL--PSPKSSPAPRRAPEQRPPAGPASAWSSS 325
S P EL+ LS + T L P SSP GP+ + S
Sbjct: 335 SNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVT---------TGPSFTFPSD 385
Query: 326 YPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAA 385
P+ LG+ P P L +A+ G P + A
Sbjct: 386 VPYQAALGTLNPPLPPP------PLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIA 439
Query: 386 RLK-----------FDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGE--HHGRLGIFPAN 432
L+ + + + EL L+KG++ + + W +G H ++G+FP N
Sbjct: 440 HLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGN 499
Query: 433 YVEVLPADEIPKPIKPPTYQVLEYGEA-----VAQYTFKGDLEVELSFRKGEHICLIRKV 487
YV P T V +A A T +G V S G +K+
Sbjct: 500 YV------------APVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGP----AQKL 543
Query: 488 NENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS 547
N G + A+++Q S + ++ L G R +A + P+
Sbjct: 544 QGNGVAGS-PSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPT 602
Query: 548 ALRSPADPIDLGGQTSPRRTGF---SFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGT 604
A +P + G SP G S + +P P T A+S SR S PL
Sbjct: 603 AAVTPIQVQNAAG-LSPASVGLSHHSLASPQPAPLMPGSATHTAAISISRA-SAPLACAA 660
Query: 605 SSPNTS 610
++P TS
Sbjct: 661 AAPLTS 666
Score = 38.1 bits (87), Expect = 0.027
Identities = 13/42 (30%), Positives = 27/42 (64%)
Query: 470 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 511
E EL ++G+ + + +K + W++G + G+ G+FP S+V+
Sbjct: 845 EAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 134 bits (338), Expect = 2e-31
Identities = 112/423 (26%), Positives = 178/423 (42%), Gaps = 73/423 (17%)
Query: 301 KSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSP-FLGRRDFVYP 359
+ P +P PPA P S++ A G A +P GSP FL
Sbjct: 122 RQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTP------GSPVFLSAAAGSTA 175
Query: 360 SSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLE 419
S R+ + S +PA + + + ++ + P +L KGDI+ + ++VD+ W
Sbjct: 176 GSLRELATSRT--APAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYH 233
Query: 420 GEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVE--LSFRK 477
GE HG G PA+Y++ + P P PP G+A+ + K + + L+F K
Sbjct: 234 GELHGTQGFLPASYIQCIQ----PLPHAPP------QGKALYDFEMKDKDQDKDCLTFTK 283
Query: 478 GEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGP----------QL 527
E + ++R+V+ENW EG + + GIFP YV+++ + + D P L
Sbjct: 284 DEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASL 341
Query: 528 PTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGF-----SFPTQEPRPQTQN 582
P+ A+ + SS A+ + +D G + + +R F + + + +
Sbjct: 342 PSDSGAVASVAPSPTLSSSGAVSAFQRRVD-GKKNTKKRHSFTALSVTHRSSQAASHRHS 400
Query: 583 LGTPGPALSHSRGPSHPLDLG----------------------------------TSSPN 608
+ P L S P +G +P
Sbjct: 401 MEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPP 460
Query: 609 TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
Q+ Y A+Y Y+PQ DELEL +G+ V+++C DGWF G S RT G FPGNYV
Sbjct: 461 KVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
Query: 669 APV 671
PV
Sbjct: 521 TPV 523
Score = 58.9 bits (141), Expect = 1e-08
Identities = 27/70 (38%), Positives = 41/70 (58%)
Query: 599 PLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQ 658
PL + P + YR + Y PQ+E E+EL+EGD V V ++ +DGW+ G +R
Sbjct: 810 PLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNG 869
Query: 659 KFGTFPGNYV 668
+ G FPG++V
Sbjct: 870 RTGLFPGSFV 879
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 9/89 (10%)
Query: 352 GRRDFVYPSSTRDPSASNGGGSPARREEKK---RKAARLKFDFQAQSPKELTLQKGDIVY 408
G D + S +R S A R E K R+ R+ + QS E+ L++GDIV+
Sbjct: 796 GSLDLNFTSPSRQAPLSMA----AIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVF 851
Query: 409 IHKEVDKNWLEG--EHHGRLGIFPANYVE 435
+HK+ + W +G + +GR G+FP ++VE
Sbjct: 852 VHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 48.1 bits (113), Expect = 3e-05
Identities = 47/185 (25%), Positives = 67/185 (36%), Gaps = 16/185 (8%)
Query: 448 PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPA 507
PP Q L +A Y +K EL KGE ++ K + W++G TG G+FP
Sbjct: 459 PPKVQ-LPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPG 517
Query: 508 SYV-QVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRR 566
+YV VSR P + L + HP S S L + R
Sbjct: 518 NYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGS----------LSSLATATR 567
Query: 567 TGFSFPTQEPRPQTQNLGTP-GPALSHSRGPSHP---LDLGTSSPNTSQIHWTPYRAMYQ 622
T + Q P G L HS P+ + T++ + +Q P +
Sbjct: 568 PALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSP 627
Query: 623 YRPQN 627
R QN
Sbjct: 628 LRTQN 632
Score = 41.2 bits (95), Expect = 0.003
Identities = 26/93 (27%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 423 HGRLGIFPANYVEVLPADEIP---KPIKP-PTYQVLEYGEAVAQYTFKGDLEVELSFRKG 478
H + G N+ P+ + P I+P P E V Y + + E+EL ++G
Sbjct: 792 HRKAGSLDLNFTS--PSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIEL--KEG 847
Query: 479 EHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 511
+ + + +K + WY+G + GR G+FP S+V+
Sbjct: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 33.5 bits (75), Expect = 0.65
Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 389 FDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGE--HHGRLGIFPANYVEVLPADEIP 443
+ ++ Q EL L KG++ + ++ W +G G G+FP NY V P +P
Sbjct: 473 YAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNY--VTPVSRVP 527
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 111 bits (277), Expect = 2e-24
Identities = 93/325 (28%), Positives = 152/325 (46%), Gaps = 53/325 (16%)
Query: 385 ARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK 444
A+ +++ Q+P +L KGDI+ + +++D+NW +GE +G G FPA+ VEV+ ++P+
Sbjct: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
Query: 445 PIKPPTYQVLEYGEAVAQYTF------KGDLEVELSFRKGEHICLIRKVNENWYEGRITG 498
P PP + L Y F K + + L+F K + I +I +V+ENW EG++
Sbjct: 188 P--PPLCRAL--------YNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL-- 235
Query: 499 TGRQGIFPASYVQVSREPR-LRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPID 557
+ GIFP +V+ + R L + G Q + L+ + S+R +S + R P
Sbjct: 236 GDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTS-TLRRGPGSRRK 294
Query: 558 LGGQTSPRRTGFSFPTQEPRPQTQNL-GTPGPALSHSRGPS------------------- 597
+ GQ S + P +++ P L S PS
Sbjct: 295 VPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVGQV 354
Query: 598 ---HPLDLG-------TSSPNTSQ-IHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCD 646
HP + S P + Q + + A++ Y DEL+L++G+ V V+ +C
Sbjct: 355 STYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQ 414
Query: 647 DGWFVGVSRRTQKFGTFPGNYVAPV 671
DGW GVS T + G FP NYV P+
Sbjct: 415 DGWLRGVSLVTGRVGIFPNNYVIPI 439
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/97 (28%), Positives = 42/97 (43%), Gaps = 2/97 (2%)
Query: 340 PHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKEL 399
P + AD S +G+ +P+ ++ P ++ + A P EL
Sbjct: 340 PMEKADVPSSCVGQVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDEL 399
Query: 400 TLQKGDIVYIHKEVDKNWLEGEH--HGRLGIFPANYV 434
LQKG+ V + + WL G GR+GIFP NYV
Sbjct: 400 DLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
Score = 40.8 bits (94), Expect = 0.004
Identities = 41/147 (27%), Positives = 61/147 (41%), Gaps = 26/147 (17%)
Query: 448 PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPA 507
P + Q L VA +++ EL +KGE + ++ K + W G TGR GIFP
Sbjct: 374 PGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPN 433
Query: 508 SYV----------QVSREPRL---------RLCDDGPQLPTSPRLTAAARSARHPSS-PS 547
+YV SR P L + G PR + +S P++ +
Sbjct: 434 NYVIPIFRKTSSFPDSRSPGLYTTWTLSTSSVSSQGSISEGDPRQSRPFKSVFVPTAIVN 493
Query: 548 ALRSPADPIDLG------GQTSPRRTG 568
+RS A P LG G++S R+ G
Sbjct: 494 PVRSTAGPGTLGQGSLRKGRSSMRKNG 520
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 105 bits (262), Expect = 1e-22
Identities = 112/445 (25%), Positives = 175/445 (39%), Gaps = 51/445 (11%)
Query: 256 KKPLVDDPGEKPSQPIEVLLERELAEL-------SAELDKDLRAIETRLPSPKSSPAPRR 308
++P P E+P P R +L +L K + T L KS +
Sbjct: 300 QQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQ 359
Query: 309 APEQRPPAGPASAWSSSYPHAPYLGSARS-----LSPHKMADGGSPFLGRRDFVYPSSTR 363
P P P S Y L + L K D G L + + P
Sbjct: 360 DPVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEH 419
Query: 364 DPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHH 423
S N + + A + DF A+ +L L G+IVY+ +++D +W G
Sbjct: 420 LRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR 479
Query: 424 GRLGIFPANYVEVLPADEIPK----PIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGE 479
++GIFPANYV+V+ +IP+ + + ++ VA++ + G+ + ELSF +GE
Sbjct: 480 NQIGIFPANYVKVI--IDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGE 537
Query: 480 HICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARS 539
I L VNE W G + GR GIFP ++V EP +D P + T
Sbjct: 538 IIILKEYVNEEWARGEV--RGRTGIFPLNFV----EP----VEDYPTSGANVLSTKVPLK 587
Query: 540 ARHPSSPSALRSPADPID----LGGQTSPRRTGFSFPTQEP------------RPQTQNL 583
+ S S + + P + L T+ SF + R + Q+
Sbjct: 588 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 647
Query: 584 GTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQ 643
PA+ P+ + P + +A+Y +R +NEDEL + GD + ++
Sbjct: 648 EGIFPAVFVRPCPAEAKSMLAIVPKGRKA-----KALYDFRGENEDELSFKAGDIITELE 702
Query: 644 QCDDGWFVGVSRRTQKFGTFPGNYV 668
DD W G K G FP NY+
Sbjct: 703 SVDDDWMSG--ELMGKSGIFPKNYI 725
Score = 75.1 bits (183), Expect = 2e-13
Identities = 42/121 (34%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Query: 391 FQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 450
F A++ +L+ ++GD + I + +D +W G R GIFPA +V PA+ K
Sbjct: 613 FTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAE-----AKSML 667
Query: 451 YQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYV 510
V + +A A Y F+G+ E ELSF+ G+ I + V+++W G + G+ GIFP +Y+
Sbjct: 668 AIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL--MGKSGIFPKNYI 725
Query: 511 Q 511
Q
Sbjct: 726 Q 726
Score = 66.2 bits (160), Expect = 9e-11
Identities = 106/482 (21%), Positives = 175/482 (36%), Gaps = 78/482 (16%)
Query: 234 DNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRA- 292
D+V S N L E G L +DP P P E + + +S +L R
Sbjct: 210 DDVLPTPSGN--LAEESVGSEMVLGLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTR 267
Query: 293 ---------------IETRLPS--------PKSSPAPRRAPEQRPPAGPASAWSSSYPHA 329
+ RLP P P P + P +RPP SA S
Sbjct: 268 NLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQP-PTKVPPERPPPPKLSATRRSNKKL 326
Query: 330 PYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKF 389
P+ S+ + K + G S A+ + K + L
Sbjct: 327 PFNRSSSDMDLQKKQSNLAT---------------------GLSKAKSQVFKNQDPVLPP 365
Query: 390 DFQAQSPKELTLQKGDIVYIHKEVDKNWLE---GEHHGRLGIFPANYVEVLPADEIPKPI 446
+ P +GD++ + K+ + N+LE GE GR+ + + L +P
Sbjct: 366 RPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPN 425
Query: 447 KPPTYQV-LEYG--EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQG 503
P Q ++ G AV + F + +L+ GE + L+ K++ +WY G + G
Sbjct: 426 DPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN--QIG 483
Query: 504 IFPASYVQV----------SREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS--ALRS 551
IFPA+YV+V RE C G + + S L+
Sbjct: 484 IFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKE 543
Query: 552 PADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP--SHPLDLGTSSP-N 608
+ G+ R F EP ++ T G + ++ P + D G++S N
Sbjct: 544 YVNEEWARGEVRGRTGIFPLNFVEP---VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVN 600
Query: 609 TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
+ W A++ + + D+L + GDR+ ++++ D W G R + G FP +V
Sbjct: 601 SLPAEWC--EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFV 656
Query: 669 AP 670
P
Sbjct: 657 RP 658
Score = 52.4 bits (124), Expect = 1e-06
Identities = 22/57 (38%), Positives = 37/57 (64%)
Query: 381 KRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVL 437
K + A+ +DF+ ++ EL+ + GDI+ + VD +W+ GE G+ GIFP NY++ L
Sbjct: 672 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
Score = 32.7 bits (73), Expect = 1.1
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
A ++Y + +DEL EG+ + + + ++ W G R + G FP N+V PV
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 105 bits (262), Expect = 1e-22
Identities = 112/445 (25%), Positives = 175/445 (39%), Gaps = 51/445 (11%)
Query: 256 KKPLVDDPGEKPSQPIEVLLERELAEL-------SAELDKDLRAIETRLPSPKSSPAPRR 308
++P P E+P P R +L +L K + T L KS +
Sbjct: 336 QQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQ 395
Query: 309 APEQRPPAGPASAWSSSYPHAPYLGSARS-----LSPHKMADGGSPFLGRRDFVYPSSTR 363
P P P S Y L + L K D G L + + P
Sbjct: 396 DPVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEH 455
Query: 364 DPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHH 423
S N + + A + DF A+ +L L G+IVY+ +++D +W G
Sbjct: 456 LRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR 515
Query: 424 GRLGIFPANYVEVLPADEIPK----PIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGE 479
++GIFPANYV+V+ +IP+ + + ++ VA++ + G+ + ELSF +GE
Sbjct: 516 NQIGIFPANYVKVI--IDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGE 573
Query: 480 HICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARS 539
I L VNE W G + GR GIFP ++V EP +D P + T
Sbjct: 574 IIILKEYVNEEWARGEV--RGRTGIFPLNFV----EP----VEDYPTSGANVLSTKVPLK 623
Query: 540 ARHPSSPSALRSPADPID----LGGQTSPRRTGFSFPTQEP------------RPQTQNL 583
+ S S + + P + L T+ SF + R + Q+
Sbjct: 624 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 683
Query: 584 GTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQ 643
PA+ P+ + P + +A+Y +R +NEDEL + GD + ++
Sbjct: 684 EGIFPAVFVRPCPAEAKSMLAIVPKGRKA-----KALYDFRGENEDELSFKAGDIITELE 738
Query: 644 QCDDGWFVGVSRRTQKFGTFPGNYV 668
DD W G K G FP NY+
Sbjct: 739 SVDDDWMSG--ELMGKSGIFPKNYI 761
Score = 75.1 bits (183), Expect = 2e-13
Identities = 42/121 (34%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Query: 391 FQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 450
F A++ +L+ ++GD + I + +D +W G R GIFPA +V PA+ K
Sbjct: 649 FTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAE-----AKSML 703
Query: 451 YQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYV 510
V + +A A Y F+G+ E ELSF+ G+ I + V+++W G + G+ GIFP +Y+
Sbjct: 704 AIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL--MGKSGIFPKNYI 761
Query: 511 Q 511
Q
Sbjct: 762 Q 762
Score = 68.2 bits (165), Expect = 2e-11
Identities = 101/462 (21%), Positives = 170/462 (36%), Gaps = 76/462 (16%)
Query: 254 RPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRA----------------IETRL 297
+P K L +DP P P E + + +S +L R + RL
Sbjct: 264 KPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRL 323
Query: 298 PS--------PKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSP 349
P P P P + P +RPP SA S P+ S+ + K +
Sbjct: 324 PPRPVNGKTIPTQQP-PTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT 382
Query: 350 FLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYI 409
G S A+ + K + L + P +GD++ +
Sbjct: 383 ---------------------GLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLVM 421
Query: 410 HKEVDKNWLE---GEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQV-LEYG--EAVAQY 463
K+ + N+LE GE GR+ + + L +P P Q ++ G AV +
Sbjct: 422 LKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLH 481
Query: 464 TFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV----------S 513
F + +L+ GE + L+ K++ +WY G + GIFPA+YV+V
Sbjct: 482 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN--QIGIFPANYVKVIIDIPEGGNGK 539
Query: 514 REPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS--ALRSPADPIDLGGQTSPRRTGFSF 571
RE C G + + S L+ + G+ R F
Sbjct: 540 RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPL 599
Query: 572 PTQEPRPQTQNLGTPGPALSHSRGP--SHPLDLGTSSP-NTSQIHWTPYRAMYQYRPQNE 628
EP ++ T G + ++ P + D G++S N+ W A++ + +
Sbjct: 600 NFVEP---VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWC--EALHSFTAETS 654
Query: 629 DELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 670
D+L + GDR+ ++++ D W G R + G FP +V P
Sbjct: 655 DDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 694
Score = 52.4 bits (124), Expect = 1e-06
Identities = 22/57 (38%), Positives = 37/57 (64%)
Query: 381 KRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVL 437
K + A+ +DF+ ++ EL+ + GDI+ + VD +W+ GE G+ GIFP NY++ L
Sbjct: 708 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
Score = 32.7 bits (73), Expect = 1.1
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
A ++Y + +DEL EG+ + + + ++ W G R + G FP N+V PV
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 100 bits (249), Expect = 4e-21
Identities = 93/351 (26%), Positives = 148/351 (42%), Gaps = 39/351 (11%)
Query: 338 LSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPK 397
L K D G L + + P S N + + A + DF A+
Sbjct: 453 LECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVD 512
Query: 398 ELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK----PIKPPTYQV 453
+L L G+IVY+ +++D +W G ++GIFPANYV+V+ +IP+ + +
Sbjct: 513 DLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNGKRECVSSHC 570
Query: 454 LEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVS 513
++ VA++ + G+ + ELSF +GE I L VNE W G + GR GIFP ++V
Sbjct: 571 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFV--- 625
Query: 514 REPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPID----LGGQTSPRRTGF 569
EP +D P + T + S S + + P + L T+
Sbjct: 626 -EP----VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDL 680
Query: 570 SFPTQEP------------RPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPY 617
SF + R + Q+ PA+ P+ + P +
Sbjct: 681 SFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA----- 735
Query: 618 RAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
+A+Y +R +NEDEL + GD + ++ DD W G K G FP NY+
Sbjct: 736 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYI 784
Score = 77.8 bits (190), Expect = 3e-14
Identities = 106/471 (22%), Positives = 180/471 (38%), Gaps = 71/471 (15%)
Query: 254 RPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRA----------------IETRL 297
+P K L +DP P P E + + +S +L R + RL
Sbjct: 264 KPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRL 323
Query: 298 PS--------PKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHK------- 342
P P P P + P +RPP SA S P+ S+ + K
Sbjct: 324 PPRPVNGKTIPTQQP-PTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT 382
Query: 343 -MADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARL-KFDFQAQSPKELT 400
++ S +D V P + G P + + D +Q+P EL+
Sbjct: 383 GLSKAKSQVFKNQDPVLPPRPKP-------GHPLYSKYMLSVPHGIANEDIVSQNPGELS 435
Query: 401 LQKGDIVYIHKEVDKNWLE---GEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQ-VLEY 456
++GD++ + K+ + N+LE GE GR+ + + L +P P Q ++
Sbjct: 436 CKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDS 495
Query: 457 G--EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV-- 512
G AV + F + +L+ GE + L+ K++ +WY G + GIFPA+YV+V
Sbjct: 496 GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVII 553
Query: 513 --------SREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS--ALRSPADPIDLGGQT 562
RE C G + + S L+ + G+
Sbjct: 554 DIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV 613
Query: 563 SPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP--SHPLDLGTSSP-NTSQIHWTPYRA 619
R F EP ++ T G + ++ P + D G++S N+ W A
Sbjct: 614 RGRTGIFPLNFVEP---VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWC--EA 668
Query: 620 MYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 670
++ + + D+L + GDR+ ++++ D W G R + G FP +V P
Sbjct: 669 LHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 717
Score = 75.1 bits (183), Expect = 2e-13
Identities = 42/121 (34%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Query: 391 FQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 450
F A++ +L+ ++GD + I + +D +W G R GIFPA +V PA+ K
Sbjct: 672 FTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAE-----AKSML 726
Query: 451 YQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYV 510
V + +A A Y F+G+ E ELSF+ G+ I + V+++W G + G+ GIFP +Y+
Sbjct: 727 AIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL--MGKSGIFPKNYI 784
Query: 511 Q 511
Q
Sbjct: 785 Q 785
Score = 52.4 bits (124), Expect = 1e-06
Identities = 22/57 (38%), Positives = 37/57 (64%)
Query: 381 KRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVL 437
K + A+ +DF+ ++ EL+ + GDI+ + VD +W+ GE G+ GIFP NY++ L
Sbjct: 731 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
Score = 32.7 bits (73), Expect = 1.1
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
A ++Y + +DEL EG+ + + + ++ W G R + G FP N+V PV
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 628
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 85.1 bits (209), Expect = 2e-16
Identities = 57/193 (29%), Positives = 99/193 (51%), Gaps = 13/193 (6%)
Query: 342 KMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREE--KKRKAARLKFDFQAQSPKEL 399
K D + +G + V+PS+ S G G+ + KK + A++ + A P++L
Sbjct: 1034 KDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQL 1093
Query: 400 TLQKGDIVYIHKEVDKNWLEGEHHGR-----LGIFPANYVEVL-PADEIPKPIKPPTYQV 453
TL G ++ I K+ W EGE R +G FPANYV++L P P +PP
Sbjct: 1094 TLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTA 1153
Query: 454 L-EYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV 512
L + + Y + + EL+F KG+ I ++ K + +W++G + G+ G+FP++YV++
Sbjct: 1154 LAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYVKL 1211
Query: 513 S--REPRLRLCDD 523
+ +P + C D
Sbjct: 1212 TTDMDPSQQWCSD 1224
Score = 83.2 bits (204), Expect = 7e-16
Identities = 107/480 (22%), Positives = 188/480 (39%), Gaps = 62/480 (12%)
Query: 220 LQPSNQVLRRREKVDNVWT-EESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERE 278
+QP + V+ + E VD T E W + +TG P P + P++ + +
Sbjct: 761 IQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTD-- 818
Query: 279 LAELSAELDKDLRAIETRLPSPK----SSPAPRRAPEQRPPAGP------ASAWSSSYPH 328
T P+PK +PAP P P +S W +S
Sbjct: 819 ---------------STSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNE 863
Query: 329 APYLGS--ARSLSPHKMADGGSPFLGRRDFVYPSST-RDPSASNGGGSPARREEKKRKAA 385
P + A + P R F ++T PS G G E+ + A
Sbjct: 864 KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQG-----EKVEGLQA 918
Query: 386 RLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLP------- 438
+ + ++A+ L K D++ + ++ D W GE G+ G FP +YV+++
Sbjct: 919 QALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKST 977
Query: 439 -----ADEIPKPIK----PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNE 489
+ E P +K P V+ E +A YT++ + +L+F++G+ + L+ K +
Sbjct: 978 SMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKDG 1036
Query: 490 NWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSAL 549
+W+ G T + G+FP++YV++ L P + A ++ + P L
Sbjct: 1037 DWWTG--TVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEI-AQVIASYTATGPEQL 1093
Query: 550 RSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSP-N 608
+ L + +P G+ + R + + +G P T P +
Sbjct: 1094 TLAPGQLILIRKKNP--GGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKS 1151
Query: 609 TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
T+ MY Y QN+DEL +G ++V+ + D W+ G + G FP NYV
Sbjct: 1152 TALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKG--EVNGQVGLFPSNYV 1209
Score = 63.9 bits (154), Expect = 5e-10
Identities = 36/92 (39%), Positives = 54/92 (58%), Gaps = 7/92 (7%)
Query: 366 SASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKE-VDKN------WL 418
+A G + + +E K R + F+++S E+T+Q GDIV + E VD++ WL
Sbjct: 726 TAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWL 785
Query: 419 EGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 450
GE G+ G FPANY E +P +E+P P+KP T
Sbjct: 786 GGELKGKTGWFPANYAEKIPENEVPAPVKPVT 817
Score = 45.8 bits (107), Expect = 1e-04
Identities = 81/359 (22%), Positives = 130/359 (36%), Gaps = 79/359 (22%)
Query: 377 REEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLE----------------- 419
+++K +A RLK Q + EL QK + +E DK WLE
Sbjct: 620 QKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEE 679
Query: 420 -------------GEHHGR------LG-IFPANYVEVLPADEIPKPIK---PPTYQVLEY 456
GE G+ LG +F + PA + P P T E
Sbjct: 680 EKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQEN 739
Query: 457 GEAV---AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGT---------GRQGI 504
+ V A Y F+ E++ + G+ I V W + TG G+ G
Sbjct: 740 VKVVYYRALYPFESRSHDEITIQPGD----IVMVKGEWVDESQTGEPGWLGGELKGKTGW 795
Query: 505 FPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALR-SPADPIDLGGQTS 563
FPA+Y + E + P P + +A A +P+ L + ++P +
Sbjct: 796 FPANYAEKIPENEV----PAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWA 851
Query: 564 PRRTGFSFPTQEPRPQTQN---------LGTPGPALSHSRGPSHPLDLGTSSPNT----- 609
+ + T E +P+T N L P R P SSP+
Sbjct: 852 DFSSTWPTSTNE-KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQG 910
Query: 610 SQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
++ +A+Y +R + ++ L + D + V++Q D WF V + G FP +YV
Sbjct: 911 EKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQK---GWFPKSYV 966
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 85.1 bits (209), Expect = 2e-16
Identities = 79/325 (24%), Positives = 144/325 (44%), Gaps = 46/325 (14%)
Query: 385 ARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK 444
A ++FD+QAQ ELT+ G+I+ ++ D W EG+ +GR G+FP N+V + +
Sbjct: 4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKD 63
Query: 445 PI------KP----PTYQVLEYGEAVAQYTFKGDL---------------EVELSFRKGE 479
P+ KP P+ L E + + +G+ + EL + G+
Sbjct: 64 PLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGD 123
Query: 480 HICLIRKVNENWYEGRITGTGRQGIFPASYVQ--VSREPRLRLCDDGPQLPTSPRLTAAA 537
I ++ +V E W+EG + G+ G+FP+++++ L + D +S R T +
Sbjct: 124 IIEVVGEVEEGWWEGVL--NGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGS 181
Query: 538 RSARHPSSPSALRSPADPIDLGGQTSPRRT-----GFSFPTQEPRPQTQNLGTPGPALSH 592
S SS S A+ P++ G F + + + +++ L
Sbjct: 182 ESDGGDSS-STKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV 240
Query: 593 SRGPSHPLDLGTSSPNTSQIHWTP-------YRAMYQYRPQNEDELELREGDRVDVMQQ- 644
+ L T++P++S+ + ++ Y QN+DEL ++EGD V ++ +
Sbjct: 241 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD 300
Query: 645 -CDDGWFVGVSRRTQKFGTFPGNYV 668
D GW+ G + G FP N+V
Sbjct: 301 CIDVGWWEG--ELNGRRGVFPDNFV 323
Score = 65.9 bits (159), Expect = 1e-10
Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 65/255 (25%)
Query: 359 PSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIV-YIHKE-VDKN 416
P++T P +S + K + ++ F ++AQ+ ELT+++GDIV I+K+ +D
Sbjct: 249 PATTATPDSSK---TEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVG 305
Query: 417 WLEGEHHGRLGIFPANYVEVLPAD-----EIPKPIKPPTYQVLEYGEAVAQYTFKGDLEV 471
W EGE +GR G+FP N+V++LP D PK PP+ V++ G +
Sbjct: 306 WWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTE--------- 356
Query: 472 ELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSP 531
RK E I+K+ E T + + REP+L L P +P P
Sbjct: 357 ----RKHE----IKKIPPERPEMLPNRTEEK-------ERPEREPKLDL--QKPSVPAIP 399
Query: 532 RLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALS 591
+ R P + S R A P P + RP GP L+
Sbjct: 400 -----PKKPRPPKTNSLSRPGALP----------------PRRPERP-------VGP-LT 430
Query: 592 HSRGPSHPLDLGTSS 606
H+RG S +DL SS
Sbjct: 431 HTRGDSPKIDLAGSS 445
Score = 54.3 bits (129), Expect = 4e-07
Identities = 22/65 (33%), Positives = 43/65 (66%)
Query: 376 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 435
+R E++R+ ++ F + Q+ EL L+ GDI+ + EV++ W EG +G+ G+FP+N+++
Sbjct: 94 KRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 153
Query: 436 VLPAD 440
L +
Sbjct: 154 ELSGE 158
Score = 42.7 bits (99), Expect = 0.001
Identities = 23/73 (31%), Positives = 43/73 (58%), Gaps = 4/73 (5%)
Query: 458 EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPR 517
EA+ ++ ++ + EL+ GE I IRK + W+EG+I GR+G+FP ++V+ ++
Sbjct: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQI--NGRRGLFPDNFVREIKKEM 60
Query: 518 LR--LCDDGPQLP 528
+ L + P+ P
Sbjct: 61 KKDPLTNKAPEKP 73
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 83.2 bits (204), Expect = 7e-16
Identities = 107/480 (22%), Positives = 188/480 (39%), Gaps = 62/480 (12%)
Query: 220 LQPSNQVLRRREKVDNVWT-EESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERE 278
+QP + V+ + E VD T E W + +TG P P + P++ + +
Sbjct: 761 IQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTD-- 818
Query: 279 LAELSAELDKDLRAIETRLPSPK----SSPAPRRAPEQRPPAGP------ASAWSSSYPH 328
T P+PK +PAP P P +S W +S
Sbjct: 819 ---------------STSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNE 863
Query: 329 APYLGS--ARSLSPHKMADGGSPFLGRRDFVYPSST-RDPSASNGGGSPARREEKKRKAA 385
P + A + P R F ++T PS G G E+ + A
Sbjct: 864 KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQG-----EKVEGLQA 918
Query: 386 RLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLP------- 438
+ + ++A+ L K D++ + ++ D W GE G+ G FP +YV+++
Sbjct: 919 QALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKST 977
Query: 439 -----ADEIPKPIK----PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNE 489
+ E P +K P V+ E +A YT++ + +L+F++G+ + L+ K +
Sbjct: 978 SMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKDG 1036
Query: 490 NWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSAL 549
+W+ G T + G+FP++YV++ L P + A ++ + P L
Sbjct: 1037 DWWTG--TVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEI-AQVIASYTATGPEQL 1093
Query: 550 RSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSP-N 608
+ L + +P G+ + R + + +G P T P +
Sbjct: 1094 TLAPGQLILIRKKNP--GGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKS 1151
Query: 609 TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
T+ MY Y QN+DEL +G ++V+ + D W+ G + G FP NYV
Sbjct: 1152 TALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKG--EVNGQVGLFPSNYV 1209
Score = 83.2 bits (204), Expect = 7e-16
Identities = 54/183 (29%), Positives = 95/183 (51%), Gaps = 11/183 (6%)
Query: 342 KMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREE--KKRKAARLKFDFQAQSPKEL 399
K D + +G + V+PS+ S G G+ + KK + A++ + A P++L
Sbjct: 1034 KDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQL 1093
Query: 400 TLQKGDIVYIHKEVDKNWLEGEHHGR-----LGIFPANYVEVL-PADEIPKPIKPPTYQV 453
TL G ++ I K+ W EGE R +G FPANYV++L P P +PP
Sbjct: 1094 TLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTA 1153
Query: 454 L-EYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV 512
L + + Y + + EL+F KG+ I ++ K + +W++G + G+ G+FP++YV++
Sbjct: 1154 LAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYVKL 1211
Query: 513 SRE 515
+ +
Sbjct: 1212 TTD 1214
Score = 63.9 bits (154), Expect = 5e-10
Identities = 36/92 (39%), Positives = 54/92 (58%), Gaps = 7/92 (7%)
Query: 366 SASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKE-VDKN------WL 418
+A G + + +E K R + F+++S E+T+Q GDIV + E VD++ WL
Sbjct: 726 TAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWL 785
Query: 419 EGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 450
GE G+ G FPANY E +P +E+P P+KP T
Sbjct: 786 GGELKGKTGWFPANYAEKIPENEVPAPVKPVT 817
Score = 45.8 bits (107), Expect = 1e-04
Identities = 81/359 (22%), Positives = 130/359 (36%), Gaps = 79/359 (22%)
Query: 377 REEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLE----------------- 419
+++K +A RLK Q + EL QK + +E DK WLE
Sbjct: 620 QKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEE 679
Query: 420 -------------GEHHGR------LG-IFPANYVEVLPADEIPKPIK---PPTYQVLEY 456
GE G+ LG +F + PA + P P T E
Sbjct: 680 EKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQEN 739
Query: 457 GEAV---AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGT---------GRQGI 504
+ V A Y F+ E++ + G+ I V W + TG G+ G
Sbjct: 740 VKVVYYRALYPFESRSHDEITIQPGD----IVMVKGEWVDESQTGEPGWLGGELKGKTGW 795
Query: 505 FPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALR-SPADPIDLGGQTS 563
FPA+Y + E + P P + +A A +P+ L + ++P +
Sbjct: 796 FPANYAEKIPENEV----PAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWA 851
Query: 564 PRRTGFSFPTQEPRPQTQN---------LGTPGPALSHSRGPSHPLDLGTSSPNT----- 609
+ + T E +P+T N L P R P SSP+
Sbjct: 852 DFSSTWPTSTNE-KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQG 910
Query: 610 SQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
++ +A+Y +R + ++ L + D + V++Q D WF V + G FP +YV
Sbjct: 911 EKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQK---GWFPKSYV 966
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 82.8 bits (203), Expect = 9e-16
Identities = 77/286 (26%), Positives = 115/286 (40%), Gaps = 25/286 (8%)
Query: 393 AQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEI----PKPI-- 446
A+ L K DI+ + E +NW GE HG G FP +YV+++P E+ P+ +
Sbjct: 884 AKKDNHLNFSKHDIITV-LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYA 942
Query: 447 ---KPPTYQVLEYGEA-VAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQ 502
K PT GE +A Y + +L+F +GE I + +K E W+ G I R
Sbjct: 943 AVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSI--GDRS 999
Query: 503 GIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQT 562
GIFP++YV+ + P + + S +P I +
Sbjct: 1000 GIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILI---L 1056
Query: 563 SPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQ 622
+G+ + R + + G + GPS P I AMY
Sbjct: 1057 KKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVI------AMYD 1110
Query: 623 YRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
Y NEDEL +G ++VM + D W+ G G FP NYV
Sbjct: 1111 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYV 1154
Score = 81.3 bits (199), Expect = 3e-15
Identities = 58/189 (30%), Positives = 97/189 (51%), Gaps = 18/189 (9%)
Query: 351 LGRRDFVYPSSTRDPS--ASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVY 408
+G R ++PS+ P S G S + KK + A++ + A ++L+L G ++
Sbjct: 995 IGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLIL 1054
Query: 409 IHKEVDKNWLEGEHHGR-----LGIFPANYVEVL-PADEIPKPIKPPTYQVLEYGEAVAQ 462
I K+ W +GE R G FPA++V++L P+ E P P QV +A
Sbjct: 1055 ILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQV------IAM 1108
Query: 463 YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVS--REPRLRL 520
Y + + E ELSF KG+ I ++ K + +W++G I G G+FP++YV+++ +P +
Sbjct: 1109 YDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV--TGLFPSNYVKMTTDSDPSQQW 1166
Query: 521 CDDGPQLPT 529
C D L T
Sbjct: 1167 CADLQTLDT 1175
Score = 55.5 bits (132), Expect = 2e-07
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 8/81 (9%)
Query: 376 RREEKKRKAA------RLKFDFQAQSPKELTLQKGDIVYIHKEV--DKNWLEGEHHGRLG 427
+ EEKKR+ A R + F+A++ E++ GDI+ + ++ + WL G G G
Sbjct: 720 KAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFG 779
Query: 428 IFPANYVEVLPADEIPKPIKP 448
FP NYVE +P+ E K + P
Sbjct: 780 WFPCNYVEKMPSSENEKAVSP 800
Score = 39.3 bits (90), Expect = 0.012
Identities = 20/54 (37%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 617 YRAMYQYRPQNEDELELREGDRVDVMQQC--DDGWFVGVSRRTQKFGTFPGNYV 668
YRA+Y + +N DE+ GD + V ++ + GW G + FG FP NYV
Sbjct: 735 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQ--GNFGWFPCNYV 786
Score = 34.7 bits (78), Expect = 0.29
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 617 YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 670
Y A+Y Y +L EG+ + V Q+ + W + R+ G FP NYV P
Sbjct: 959 YIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS---GIFPSNYVKP 1009
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 82.8 bits (203), Expect = 9e-16
Identities = 77/286 (26%), Positives = 115/286 (40%), Gaps = 25/286 (8%)
Query: 393 AQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEI----PKPI-- 446
A+ L K DI+ + E +NW GE HG G FP +YV+++P E+ P+ +
Sbjct: 911 AKKDNHLNFSKHDIITV-LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYA 969
Query: 447 ---KPPTYQVLEYGEA-VAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQ 502
K PT GE +A Y + +L+F +GE I + +K E W+ G I R
Sbjct: 970 AVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSI--GDRS 1026
Query: 503 GIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQT 562
GIFP++YV+ + P + + S +P I +
Sbjct: 1027 GIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILI---L 1083
Query: 563 SPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQ 622
+G+ + R + + G + GPS P I AMY
Sbjct: 1084 KKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVI------AMYD 1137
Query: 623 YRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
Y NEDEL +G ++VM + D W+ G G FP NYV
Sbjct: 1138 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYV 1181
Score = 81.3 bits (199), Expect = 3e-15
Identities = 58/189 (30%), Positives = 97/189 (51%), Gaps = 18/189 (9%)
Query: 351 LGRRDFVYPSSTRDPS--ASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVY 408
+G R ++PS+ P S G S + KK + A++ + A ++L+L G ++
Sbjct: 1022 IGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLIL 1081
Query: 409 IHKEVDKNWLEGEHHGR-----LGIFPANYVEVL-PADEIPKPIKPPTYQVLEYGEAVAQ 462
I K+ W +GE R G FPA++V++L P+ E P P QV +A
Sbjct: 1082 ILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQV------IAM 1135
Query: 463 YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVS--REPRLRL 520
Y + + E ELSF KG+ I ++ K + +W++G I G G+FP++YV+++ +P +
Sbjct: 1136 YDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV--TGLFPSNYVKMTTDSDPSQQW 1193
Query: 521 CDDGPQLPT 529
C D L T
Sbjct: 1194 CADLQTLDT 1202
Score = 55.5 bits (132), Expect = 2e-07
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 8/81 (9%)
Query: 376 RREEKKRKAA------RLKFDFQAQSPKELTLQKGDIVYIHKEV--DKNWLEGEHHGRLG 427
+ EEKKR+ A R + F+A++ E++ GDI+ + ++ + WL G G G
Sbjct: 747 KAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFG 806
Query: 428 IFPANYVEVLPADEIPKPIKP 448
FP NYVE +P+ E K + P
Sbjct: 807 WFPCNYVEKMPSSENEKAVSP 827
Score = 39.3 bits (90), Expect = 0.012
Identities = 20/54 (37%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 617 YRAMYQYRPQNEDELELREGDRVDVMQQC--DDGWFVGVSRRTQKFGTFPGNYV 668
YRA+Y + +N DE+ GD + V ++ + GW G + FG FP NYV
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQ--GNFGWFPCNYV 813
Score = 34.7 bits (78), Expect = 0.29
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 617 YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 670
Y A+Y Y +L EG+ + V Q+ + W + R+ G FP NYV P
Sbjct: 986 YIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS---GIFPSNYVKP 1036
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 82.8 bits (203), Expect = 9e-16
Identities = 77/286 (26%), Positives = 115/286 (40%), Gaps = 25/286 (8%)
Query: 393 AQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEI----PKPI-- 446
A+ L K DI+ + E +NW GE HG G FP +YV+++P E+ P+ +
Sbjct: 911 AKKDNHLNFSKHDIITV-LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYA 969
Query: 447 ---KPPTYQVLEYGEA-VAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQ 502
K PT GE +A Y + +L+F +GE I + +K E W+ G I R
Sbjct: 970 AVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSI--GDRS 1026
Query: 503 GIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQT 562
GIFP++YV+ + P + + S +P I +
Sbjct: 1027 GIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILI---L 1083
Query: 563 SPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQ 622
+G+ + R + + G + GPS P I AMY
Sbjct: 1084 KKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVI------AMYD 1137
Query: 623 YRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
Y NEDEL +G ++VM + D W+ G G FP NYV
Sbjct: 1138 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYV 1181
Score = 81.3 bits (199), Expect = 3e-15
Identities = 58/189 (30%), Positives = 97/189 (51%), Gaps = 18/189 (9%)
Query: 351 LGRRDFVYPSSTRDPS--ASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVY 408
+G R ++PS+ P S G S + KK + A++ + A ++L+L G ++
Sbjct: 1022 IGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLIL 1081
Query: 409 IHKEVDKNWLEGEHHGR-----LGIFPANYVEVL-PADEIPKPIKPPTYQVLEYGEAVAQ 462
I K+ W +GE R G FPA++V++L P+ E P P QV +A
Sbjct: 1082 ILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQV------IAM 1135
Query: 463 YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVS--REPRLRL 520
Y + + E ELSF KG+ I ++ K + +W++G I G G+FP++YV+++ +P +
Sbjct: 1136 YDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV--TGLFPSNYVKMTTDSDPSQQW 1193
Query: 521 CDDGPQLPT 529
C D L T
Sbjct: 1194 CADLQTLDT 1202
Score = 55.5 bits (132), Expect = 2e-07
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 8/81 (9%)
Query: 376 RREEKKRKAA------RLKFDFQAQSPKELTLQKGDIVYIHKEV--DKNWLEGEHHGRLG 427
+ EEKKR+ A R + F+A++ E++ GDI+ + ++ + WL G G G
Sbjct: 747 KAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFG 806
Query: 428 IFPANYVEVLPADEIPKPIKP 448
FP NYVE +P+ E K + P
Sbjct: 807 WFPCNYVEKMPSSENEKAVSP 827
Score = 39.3 bits (90), Expect = 0.012
Identities = 20/54 (37%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 617 YRAMYQYRPQNEDELELREGDRVDVMQQC--DDGWFVGVSRRTQKFGTFPGNYV 668
YRA+Y + +N DE+ GD + V ++ + GW G + FG FP NYV
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQ--GNFGWFPCNYV 813
Score = 34.7 bits (78), Expect = 0.29
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 617 YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 670
Y A+Y Y +L EG+ + V Q+ + W + R+ G FP NYV P
Sbjct: 986 YIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS---GIFPSNYVKP 1036
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 79.3 bits (194), Expect = 1e-14
Identities = 79/297 (26%), Positives = 117/297 (39%), Gaps = 83/297 (27%)
Query: 391 FQAQSPKELTLQKGDIVYIHKEVD-KNWLEGEHHGRLGIFPANYVEVLP----------- 438
++AQ EL+L GD+V + V + WL GE GR G+FP V+ +P
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 439 ---ADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 495
A P K P Q +++ + EL + GE + +I+++ + W+ G+
Sbjct: 69 PRCARRRGHPAKHPRPQ----RWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGK 124
Query: 496 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADP 555
G+ G FP+++V+ L D GP S +P PS P P
Sbjct: 125 --KNGQLGAFPSNFVE--------LLDSGPP------------SLGNPDMPSVSPGPQRP 162
Query: 556 IDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWT 615
P LS S P L T S H
Sbjct: 163 --------------------------------PKLSSLAYDSPPDYLQTVS------HPE 184
Query: 616 PYRAMYQYRPQNEDELELREGDRVDVMQQC--DDGWFVGVSRRTQKFGTFPGNYVAP 670
YR ++ Y+P+ DEL LR GD V V+ + D GW+ G + + G FP N+V P
Sbjct: 185 VYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPDNFVLP 239
Score = 74.7 bits (182), Expect = 3e-13
Identities = 72/268 (26%), Positives = 118/268 (44%), Gaps = 56/268 (20%)
Query: 363 RDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEH 422
R P + G PA+ +R ++ F + + EL LQ G+IV + KE++ W G+
Sbjct: 67 RRPRCARRRGHPAKHPRPQRWC-KVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKK 125
Query: 423 HGRLGIFPANYVEVLPA-----------DEIPKPIKPPTYQVL------EYGEAVAQ--- 462
+G+LG FP+N+VE+L + P P +PP L +Y + V+
Sbjct: 126 NGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEV 185
Query: 463 ----YTFKGDLEVELSFRKGEHICLIRKVNEN--WYEGRITGTGRQGIFPASYV------ 510
+ ++ + EL+ R+G+ + ++ K E+ W+EG GR+G+FP ++V
Sbjct: 186 YRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGEC--QGRRGVFPDNFVLPPPPI 243
Query: 511 -------QVSRE----PRLRLCDDGPQLPTSPRLTAA------ARSARHPSSPSALRSPA 553
VSRE + LPT +L A A+++R PS S +
Sbjct: 244 KKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSR 303
Query: 554 DPIDLGGQTSPRRTGFSFPTQEPRPQTQ 581
D GG S G S+ R +TQ
Sbjct: 304 DSGPNGGFQS----GGSYHPGRKRSKTQ 327
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.133 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,202,822
Number of Sequences: 37866
Number of extensions: 2014772
Number of successful extensions: 9755
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 225
Number of HSP's successfully gapped in prelim test: 350
Number of HSP's that attempted gapping in prelim test: 7999
Number of HSP's gapped (non-prelim): 1842
length of query: 671
length of database: 18,247,518
effective HSP length: 109
effective length of query: 562
effective length of database: 14,120,124
effective search space: 7935509688
effective search space used: 7935509688
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.