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Search of human proteins with 153945846
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo
sapiens]
(2671 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo ... 5319 0.0
gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo s... 3421 0.0
gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isofor... 3280 0.0
gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isofor... 3277 0.0
gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens] 162 4e-39
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ... 161 9e-39
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ... 161 9e-39
gi|126032338 ryanodine receptor 3 [Homo sapiens] 160 2e-38
gi|31982906 cingulin-like 1 [Homo sapiens] 39 0.069
gi|56550043 sarcolemma associated protein [Homo sapiens] 38 0.12
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens] 37 0.26
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ... 37 0.34
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 36 0.44
gi|157266264 pleckstrin homology-like domain, family B, member 3... 35 0.99
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 34 1.7
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 34 2.2
gi|219689136 coiled-coil domain containing 68 [Homo sapiens] 34 2.2
gi|13376818 coiled-coil domain containing 68 [Homo sapiens] 34 2.2
gi|62414289 vimentin [Homo sapiens] 34 2.2
gi|4758648 kinesin family member 5B [Homo sapiens] 34 2.2
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 34 2.2
gi|24308111 FGFR1 oncogene partner 2 [Homo sapiens] 34 2.2
gi|221219020 NYD-SP11 protein [Homo sapiens] 33 2.9
gi|157739936 chromosome 10 open reading frame 68 [Homo sapiens] 33 2.9
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 33 3.8
gi|4503593 epidermal growth factor receptor pathway substrate 15... 33 3.8
gi|195976805 hypoxia up-regulated 1 precursor [Homo sapiens] 33 3.8
gi|5453832 hypoxia up-regulated 1 precursor [Homo sapiens] 33 3.8
gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform ... 33 3.8
gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1... 33 3.8
>gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo
sapiens]
Length = 2671
Score = 5319 bits (13799), Expect = 0.0
Identities = 2671/2671 (100%), Positives = 2671/2671 (100%)
Query: 1 MSEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVC 60
MSEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVC
Sbjct: 1 MSEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVC 60
Query: 61 PMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGS 120
PMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGS
Sbjct: 61 PMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGS 120
Query: 121 VIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVG 180
VIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVG
Sbjct: 121 VIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVG 180
Query: 181 DKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDV 240
DKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDV
Sbjct: 181 DKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDV 240
Query: 241 VRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHW 300
VRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHW
Sbjct: 241 VRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHW 300
Query: 301 NGLYRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHG 360
NGLYRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHG
Sbjct: 301 NGLYRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHG 360
Query: 361 NDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTC 420
NDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTC
Sbjct: 361 NDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTC 420
Query: 421 PTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLV 480
PTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLV
Sbjct: 421 PTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLV 480
Query: 481 FFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGEGPLVRLEE 540
FFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGEGPLVRLEE
Sbjct: 481 FFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGEGPLVRLEE 540
Query: 541 LSDQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLH 600
LSDQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLH
Sbjct: 541 LSDQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLH 600
Query: 601 NNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPK 660
NNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPK
Sbjct: 601 NNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPK 660
Query: 661 NSDILIRTELRPVKEMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNA 720
NSDILIRTELRPVKEMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNA
Sbjct: 661 NSDILIRTELRPVKEMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNA 720
Query: 721 HDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRASFCHL 780
HDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRASFCHL
Sbjct: 721 HDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRASFCHL 780
Query: 781 MLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTMEFVEDY 840
MLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTMEFVEDY
Sbjct: 781 MLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTMEFVEDY 840
Query: 841 LNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQGPPA 900
LNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQGPPA
Sbjct: 841 LNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQGPPA 900
Query: 901 MLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDRSKFEENE 960
MLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDRSKFEENE
Sbjct: 901 MLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDRSKFEENE 960
Query: 961 DIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSTT 1020
DIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSTT
Sbjct: 961 DIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSTT 1020
Query: 1021 ANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVSGALQLLFK 1080
ANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVSGALQLLFK
Sbjct: 1021 ANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVSGALQLLFK 1080
Query: 1081 HFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSGKGEEVE 1140
HFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSGKGEEVE
Sbjct: 1081 HFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSGKGEEVE 1140
Query: 1141 AGAAKDKKERPTDEEGFLHPPGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNM 1200
AGAAKDKKERPTDEEGFLHPPGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNM
Sbjct: 1141 AGAAKDKKERPTDEEGFLHPPGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNM 1200
Query: 1201 DAHKVMLDLLQIPYDKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTPGLLE 1260
DAHKVMLDLLQIPYDKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTPGLLE
Sbjct: 1201 DAHKVMLDLLQIPYDKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTPGLLE 1260
Query: 1261 AETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDM 1320
AETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDM
Sbjct: 1261 AETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDM 1320
Query: 1321 IMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEGKN 1380
IMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEGKN
Sbjct: 1321 IMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEGKN 1380
Query: 1381 VYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNHIWTL 1440
VYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNHIWTL
Sbjct: 1381 VYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNHIWTL 1440
Query: 1441 FENFTLDMARVCSKREKRVADPTLEKYVLSVVLDTINAFFSSPFSENSTSLQTHQTIVVQ 1500
FENFTLDMARVCSKREKRVADPTLEKYVLSVVLDTINAFFSSPFSENSTSLQTHQTIVVQ
Sbjct: 1441 FENFTLDMARVCSKREKRVADPTLEKYVLSVVLDTINAFFSSPFSENSTSLQTHQTIVVQ 1500
Query: 1501 LLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMDLDAHISSMLSSGASCAA 1560
LLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMDLDAHISSMLSSGASCAA
Sbjct: 1501 LLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMDLDAHISSMLSSGASCAA 1560
Query: 1561 AAQRNASSYKATTRAFPRVTPTANQWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDV 1620
AAQRNASSYKATTRAFPRVTPTANQWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDV
Sbjct: 1561 AAQRNASSYKATTRAFPRVTPTANQWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDV 1620
Query: 1621 LHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLMESEEKLCIKVLRTLQQMLLKKTKYG 1680
LHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLMESEEKLCIKVLRTLQQMLLKKTKYG
Sbjct: 1621 LHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLMESEEKLCIKVLRTLQQMLLKKTKYG 1680
Query: 1681 DRGNQLRKMLLQNYLQNRKSTSRGDLPDPIGTGLDPDWSAIAATQCRLDKEGATKLVCDL 1740
DRGNQLRKMLLQNYLQNRKSTSRGDLPDPIGTGLDPDWSAIAATQCRLDKEGATKLVCDL
Sbjct: 1681 DRGNQLRKMLLQNYLQNRKSTSRGDLPDPIGTGLDPDWSAIAATQCRLDKEGATKLVCDL 1740
Query: 1741 ITSTKNEKIFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQET 1800
ITSTKNEKIFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQET
Sbjct: 1741 ITSTKNEKIFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQET 1800
Query: 1801 KSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRYSLGPSLRRGHEVSERVQS 1860
KSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRYSLGPSLRRGHEVSERVQS
Sbjct: 1801 KSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRYSLGPSLRRGHEVSERVQS 1860
Query: 1861 SEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTG 1920
SEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTG
Sbjct: 1861 SEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTG 1920
Query: 1921 GLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISP 1980
GLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISP
Sbjct: 1921 GLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISP 1980
Query: 1981 LCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERE 2040
LCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERE
Sbjct: 1981 LCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERE 2040
Query: 2041 NSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQML 2100
NSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQML
Sbjct: 2041 NSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQML 2100
Query: 2101 KSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTTTE 2160
KSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTTTE
Sbjct: 2101 KSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTTTE 2160
Query: 2161 QDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIA 2220
QDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIA
Sbjct: 2161 QDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIA 2220
Query: 2221 FFYPYMEGASTGVLDSPLISLLFWILICFSIAALFTKRYSIRPLIVALILRSIYYLGIGP 2280
FFYPYMEGASTGVLDSPLISLLFWILICFSIAALFTKRYSIRPLIVALILRSIYYLGIGP
Sbjct: 2221 FFYPYMEGASTGVLDSPLISLLFWILICFSIAALFTKRYSIRPLIVALILRSIYYLGIGP 2280
Query: 2281 TLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELF 2340
TLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELF
Sbjct: 2281 TLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELF 2340
Query: 2341 YSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVD 2400
YSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVD
Sbjct: 2341 YSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVD 2400
Query: 2401 RLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGLSVPEVLEEDRELDSTERACDTLLM 2460
RLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGLSVPEVLEEDRELDSTERACDTLLM
Sbjct: 2401 RLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGLSVPEVLEEDRELDSTERACDTLLM 2460
Query: 2461 CIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTF 2520
CIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTF
Sbjct: 2461 CIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTF 2520
Query: 2521 ADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNK 2580
ADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNK
Sbjct: 2521 ADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNK 2580
Query: 2581 TDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLNSTMKLVSHLT 2640
TDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLNSTMKLVSHLT
Sbjct: 2581 TDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLNSTMKLVSHLT 2640
Query: 2641 AQLNELKEQMTEQRKRRQRLGFVDVQNCISR 2671
AQLNELKEQMTEQRKRRQRLGFVDVQNCISR
Sbjct: 2641 AQLNELKEQMTEQRKRRQRLGFVDVQNCISR 2671
>gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo
sapiens]
Length = 2701
Score = 3421 bits (8871), Expect = 0.0
Identities = 1765/2728 (64%), Positives = 2099/2728 (76%), Gaps = 111/2728 (4%)
Query: 3 EMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPM 62
+MSSFL+IGDIVSLYAEGSVNGFISTLGLVDDRCVV P AGDL NPPKKFRDCLFKVCPM
Sbjct: 4 KMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPM 63
Query: 63 NRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVI 122
NRYSAQKQYWKAKQ KQ + LL+KLQHAA++EQKQN++ENKK+ G++VKY +VI
Sbjct: 64 NRYSAQKQYWKAKQAKQGNH--TEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVI 121
Query: 123 QLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDK 182
QLLH+KSNKYLTVNKRLPALLEKNAMRV+LDA GNEGSW +I PFWKLRS GDN+VVGDK
Sbjct: 122 QLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDK 181
Query: 183 VILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVR 242
V+L PVNAGQPLHASN EL DN GCKEVN+VNCNTSWKI LFM++ + E+VLKGGDVVR
Sbjct: 182 VVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVR 241
Query: 243 LFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNG 302
LFHAEQEKFLTCDEY+ K +FLRTTLRQSATSATSS ALWE+EVVHHDPCRGGAG WN
Sbjct: 242 LFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNS 301
Query: 303 LYRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGR-RNAGEKIKYCLVAVPHGN 361
L+RFKHLATGNYLAAE NP Y+ ++ K G + + R AGEKI Y LV+VPHGN
Sbjct: 302 LFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHGN 361
Query: 362 DIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCP 421
DIASLFELD TTLQ+ D VPRNSYVRLRHLCTNTW+ ST++PID +EERP+ L +GTC
Sbjct: 362 DIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQ 421
Query: 422 TKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVF 481
TKEDKEAFAIVSVP+SE+RDLDFANDA+ +LA+ V+KL G I+QN+RRFV +LLEDL+F
Sbjct: 422 TKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLIF 481
Query: 482 FVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGEGPLVRLEEL 541
FV+DVPNNGQ VLD+++TKPNRERQKLMREQNIL QVFGILKAPF+EK GEG ++RLE+L
Sbjct: 482 FVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLEDL 541
Query: 542 SDQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHN 601
DQ+ APY++M RLCYRVLRHSQ+DYRKNQE+IAK F +MQSQIGYDILAEDTITALLHN
Sbjct: 542 GDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHN 601
Query: 602 NRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKN 661
NRKLLEKHIT E+ETFVSL+R+NREPRFLDYLSDLCVSN AIPVTQELICK +L P N
Sbjct: 602 NRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGN 661
Query: 662 SDILIRTELRPVK-EMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNA 720
+DILI+T++ ++ + LS + +EEVWL W D N E H K++R LAQEA+ G
Sbjct: 662 ADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTK 721
Query: 721 HDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRASFCHL 780
D VL+YYRYQL LFARMCLDRQYLAI++IS QL VDLI C++DE LPFDLRASFC L
Sbjct: 722 ADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRL 781
Query: 781 MLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTMEFVEDY 840
MLH+HVDRDPQE V PV++ARLWTEIPT ITI +YDS ++SR+D K KFA TMEFVE+Y
Sbjct: 782 MLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEEY 841
Query: 841 LNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQGPPA 900
L VV++ PF ++EKNKLTFEVV LA NLIYFGFYSFSELLRLTRTLL I+D VQ P +
Sbjct: 842 LKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMS 901
Query: 901 ----MLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDRSKF 956
L ++D GG NV R+I GVG MM+ MVLSR S+F S+ + P +
Sbjct: 902 SYFERLSKFQD-GGNNVMRTIHGVGEMMTQMVLSR-GSIFPM-SVPDVPPSIHPSKQGSP 958
Query: 957 EENEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAF 1016
E+ED+ VM+TKLKI+EILQFIL+VRLDYRISY+LS++KKEF E ++ A G+
Sbjct: 959 TEHEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTL 1018
Query: 1017 DSTTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVSGALQ 1076
+ ++D I QAE MF K + +++DDEGGR FLRVLIHL MHDY PL+SGALQ
Sbjct: 1019 LPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQ 1078
Query: 1077 LLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSGKG 1136
LLFKHFSQR E + FKQVQLL+S QDV+NYK IK++LD+LR VEKSELWV+K + +
Sbjct: 1079 LLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYEN 1138
Query: 1137 EEVEAGAAKDKKERPTDEEGFLHPPGE---------KSSENYQIVKGILERLNKMCGVGE 1187
E+ K +E P +E L P + S NY+IVK IL RL+K+C +
Sbjct: 1139 GEIGESQVKGGEE-PIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNK 1197
Query: 1188 QMRKKQQRLLKNMDAHKVMLDLLQIPYDKGDAKMMEILRYTHQFLQKFCAGNPGNQALLH 1247
+ R + QRLLKNM AH V+LDLLQIPY+K D KM E++ H FLQ FC GNP NQ LLH
Sbjct: 1198 KCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLH 1257
Query: 1248 KHLHLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVI 1307
KHL+LFLTPGLLEAETM+HIF+NNY LC+EISE V+QHFVH + THGRHV+YL FL T++
Sbjct: 1258 KHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIV 1317
Query: 1308 KAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHIS 1367
KA+GKYVKKCQDM+MTEL N G+DV++FYND+AS LL MM + RD ++ PL YHI+
Sbjct: 1318 KADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHIT 1377
Query: 1368 LVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVE 1427
LV+LLAAC EGKNVYTEIKC SLLPL+D+V VVTH+DCI EVK+AYVNFVNHCYVDTEVE
Sbjct: 1378 LVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVE 1437
Query: 1428 MKEIYTSNHIWTLFENFTLDMARVC-SKREKRVADPTLEKYVLSVVLDTINAFFSSPFSE 1486
MKEIYTSNHIW LFENF +DMARVC + +++ AD LEK V +++ ++ FF+SPFS+
Sbjct: 1438 MKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSD 1497
Query: 1487 NSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMDLDA 1546
NSTSLQTHQ + +QLLQS R+ C W K SVE+CIRTLA VAK R I +P+DLD+
Sbjct: 1498 NSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLDS 1557
Query: 1547 HISSMLSSGASCAAAAQRNASSYKATTRAFPRVTPTAN--QWDYKNIIEKLQDIITALEE 1604
++++ S + QR A ++ + R+ PR WDY+NIIEKLQD++ +LE
Sbjct: 1558 QVNTLFMK--SHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEH 1615
Query: 1605 RLKPLVQAELSVLVDVLHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLMESEEKLCIK 1664
+ P++QAE SVLVDVL+ PELLF EGS+A RC G F+SKLI HTK LME EEKLCIK
Sbjct: 1616 QFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKKLMEKEEKLCIK 1673
Query: 1665 VLRTLQQMLLKKTKYGDRGNQLRKMLLQNYLQNRKSTS-RGDLPDPIG---------TGL 1714
+L+TL++ML KK + + GN LRK+LL Y + S G L +G
Sbjct: 1674 ILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQ 1733
Query: 1715 DPDWSAIAAT--QCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIHLLDGGNTEIQKSF 1772
D D I+ + QC LDKEGA++LV D+I +TKN++IF E I L I LL+GGNT+ Q SF
Sbjct: 1734 DSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSF 1793
Query: 1773 HNLMMSDKKSERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHED---------REPVD 1823
+ + KKSE+FFKVL+DRMK AQ+E +STV VN DLG++ +D R V
Sbjct: 1794 YQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVR 1853
Query: 1824 PTT-------KGRVASFSIPGSSS----RYSLGPSL-------RRGHEVSERVQSSEMGT 1865
+T KG++ S S + R + P + G+ + + M
Sbjct: 1854 DSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSP 1913
Query: 1866 SVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLL 1925
++ IMQPILRFLQLLCENHNR+LQNFLR QNNKTNYNLVCETLQFLD +CGSTTGGLGLL
Sbjct: 1914 AIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLL 1973
Query: 1926 GLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISPLCKYR 1985
GLYINE NV LV Q LE+LTEYCQGPCHENQTCI THESNGIDII ALILNDI+PL KYR
Sbjct: 1974 GLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYR 2033
Query: 1986 MDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQ-------EEE 2038
MDLVLQLK+NASKLLLA+MESRHDSENAERIL ++RP+ELVDV+K AY Q ++E
Sbjct: 2034 MDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDE 2093
Query: 2039 RENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQ 2098
+ VSP++VGHNIYILA QL+RHNK LQ +LKP
Sbjct: 2094 GGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKP------------------------- 2128
Query: 2099 MLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTT 2158
S P +E ++ L YY NHT+QIEIVR DR+MEQIVFPVP IC++LT E+K R+F T
Sbjct: 2129 ---GSDP--DEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNT 2183
Query: 2159 TEQDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSISFNLAVFINII 2218
TE+DEQGSKV+DFF Q+ L+NEM+WQ+K+R+ P ++WFSR ++LWGSISFNLAVFIN+
Sbjct: 2184 TERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLA 2243
Query: 2219 IAFFYPYMEGASTGVLDSPLISLLFWI--LICFSIAALFTKRYSIRPLIVALILRSIYYL 2276
+A FYP+ + G L SPL S+L WI IC S+ F+K IRP +V+++LRSIY +
Sbjct: 2244 VALFYPFGDDGDEGTL-SPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTI 2302
Query: 2277 GIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFA 2336
G+GPTL +LGA NL NKIVF+VSFVGNRGTF RGY+A+++DM FLYHV Y+L +LGLF
Sbjct: 2303 GLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFV 2362
Query: 2337 HELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFI 2396
HE FYS LLFDL+YREETL NVIKSVTRNGRSI+LTA+LALILVYLFSI+GFLFLKDDF
Sbjct: 2363 HEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFT 2422
Query: 2397 LEVDRLPNNHSTASPLGMP-HGAAAFVDTCSGDKMDCVSGLSVPEVLEEDRELDSTERAC 2455
+EVDRL N +P ++ C+ K +C + +E+ E D ER C
Sbjct: 2423 MEVDRLKNRTPVTGSHQVPTMTLTTMMEACA--KENCSPTIPASNTADEEYE-DGIERTC 2479
Query: 2456 DTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGV 2515
DTLLMCIVTV+N GLRNGGGVGD+LR+PSKDE LF ARVVYDLLF+FIVIIIVLNLIFGV
Sbjct: 2480 DTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGV 2539
Query: 2516 IIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLV 2575
IIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIK EHNMW+YLYFIVLV
Sbjct: 2540 IIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLV 2599
Query: 2576 RVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLNSTMKL 2635
+VK+ T+YTGPESYVAQMI KNLDWFPRMRAMSLVSNEG+ EQNEIR LQ+KL STM L
Sbjct: 2600 KVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSL 2659
Query: 2636 VSHLTAQLNELKEQMTEQRKRRQRLGFV 2663
V L+ QL ELKEQMTEQRK +QRLGF+
Sbjct: 2660 VKQLSGQLAELKEQMTEQRKNKQRLGFL 2687
>gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isoform 1
[Homo sapiens]
Length = 2710
Score = 3280 bits (8504), Expect = 0.0
Identities = 1700/2742 (61%), Positives = 2085/2742 (76%), Gaps = 130/2742 (4%)
Query: 3 EMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPM 62
+MSSFLHIGDI SLYAEGS NGFISTLGLVDDRCVV+P GDL+NPPKKFRDCLFK+CPM
Sbjct: 4 KMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPM 63
Query: 63 NRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVI 122
NRYSAQKQ+WKA K D VLL KL HAA +E+KQN+TEN+K+ G V++YG+VI
Sbjct: 64 NRYSAQKQFWKA--AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVI 121
Query: 123 QLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDK 182
QLLH+KSNKYLTVNKRLPALLEKNAMRVTLD GNEGSW +IQPF+KLRS GD+VV+GDK
Sbjct: 122 QLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDK 181
Query: 183 VILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVR 242
V+LNPVNAGQPLHAS+++L DN GC EVNSVNCNTSWKI LFM++ D+ +++LKGGDVVR
Sbjct: 182 VVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVR 241
Query: 243 LFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNG 302
LFHAEQEKFLTCDE++ K VFLRTT RQSATSATSS ALWEVEVV HDPCRGGAG+WN
Sbjct: 242 LFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNS 301
Query: 303 LYRFKHLATGNYLAAEENPSYKGDASD--PKAAGMGAQGRTGRRNAGEKIKYCLVAVPHG 360
L+RFKHLATG+YLAAE +P ++ + + P R+ RNA EK+ Y LV+VP G
Sbjct: 302 LFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPEG 361
Query: 361 NDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTC 420
NDI+S+FELDPTTL+ DS VPRNSYVRLRHLCTNTW+ STN+PID EEE+P+ L +GT
Sbjct: 362 NDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTS 421
Query: 421 PTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLV 480
P KEDKEAFAIV V +E+RDLDFANDAS +L S KL +G I+QN+RR V +LLEDLV
Sbjct: 422 PVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLV 481
Query: 481 FFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGEGPLVRLEE 540
+FV+ N+GQ+VL+++ +KPNRERQKLMREQNILKQ+F +L+APF + G+GP++RLEE
Sbjct: 482 YFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTD-CGDGPMLRLEE 540
Query: 541 LSDQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLH 600
L DQ++AP++H+ RLCYRVLRHSQ+DYRKNQE+IAKQFG MQ QIGYD+LAEDTITALLH
Sbjct: 541 LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH 600
Query: 601 NNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPK 660
NNRKLLEKHIT E++TFVSLVRKNREPRFLDYLSDLCVS + +IPVTQELICK VL+P
Sbjct: 601 NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT 660
Query: 661 NSDILIRTELRPVK-----EMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEA 715
N+DILI T+L + + L EEEVWL W D N E KSVR+LAQ+A
Sbjct: 661 NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA 720
Query: 716 RAGNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRA 775
+ G D +VLSYYRYQL LFARMCLDRQYLAI+EIS QL VDLI CM+DE LP+DLRA
Sbjct: 721 KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA 780
Query: 776 SFCHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTME 835
SFC LMLH+HVDRDPQE VTPVK+ARLW+EIP+ I I DYDS+ AS+D+ K +FA TME
Sbjct: 781 SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSS-GASKDEIKERFAQTME 839
Query: 836 FVEDYLNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCV 895
FVE+YL +VV + PF+++EKNKLTFEVV+LA NLIYFGFY+FS+LLRLT+ LL I+DCV
Sbjct: 840 FVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCV 899
Query: 896 Q----GPPAMLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPL 951
P + + E+ G NV RSI GVG +M+ +VL + P A+A E
Sbjct: 900 HVTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPM----AAAPEGN 955
Query: 952 DRSKFEENEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPM--QDSGA 1009
+ E EDI+VM+TKLKI+EILQFILNVRLDYRIS LL +FK+EF E + S
Sbjct: 956 VKQAEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSG 1015
Query: 1010 DGTAPAFDSTTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAP 1069
+ + + ++ + I EQAE +FG K ++ L++DD GGR FLRVL+HLTMHDY P
Sbjct: 1016 NSSQEGPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPP 1075
Query: 1070 LVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVD 1129
LVSGALQLLF+HFSQRQE + FKQVQLL+++QDV+NYK IK +LD+LR++VEKSELWV
Sbjct: 1076 LVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVY 1135
Query: 1130 KKGSGKGEEVEAGAAKDKKERPTDEEGFLHPPGEK--SSENYQIVKGILERLNKMC---- 1183
K G+G + A + E EEG P + SS NY++VK IL RL+K+C
Sbjct: 1136 K---GQGPDETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQES 1192
Query: 1184 GVGEQMRKKQQRLLKNMDAHKVMLDLLQIPYDKG-DAKMMEILRYTHQFLQKFCAGNPGN 1242
+ RK+QQRLL+NM AH V+L+LLQIPY+K D KM EI+R H+FLQ FCAGN N
Sbjct: 1193 ASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQN 1252
Query: 1243 QALLHKHLHLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDF 1302
QALLHKH++LFL PG+LEA TMQHIF+NN+QLCSEI+E V+QHFVH + THGR+VQY+ F
Sbjct: 1253 QALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKF 1312
Query: 1303 LHTVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPL 1362
L T++KAEGK++KKCQDM+M EL N+G+DV+VFYND+AS L+ MM++ RD ++++SPL
Sbjct: 1313 LQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPL 1372
Query: 1363 MYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYV 1422
MYHI LV+LLA C EGKNVYTEIKC SLLPL+D+V VVTHEDCI EVK+AY+NF+NHCYV
Sbjct: 1373 MYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYV 1432
Query: 1423 DTEVEMKEIYTSNHIWTLFENFTLDMARVCSK-REKRVADPTLEKYVLSVVLDTINAFFS 1481
DTEVEMKEIYTSNH+W LFENF +D+ R C+ +++ AD LEKYV +V+ + FFS
Sbjct: 1433 DTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFS 1492
Query: 1482 SPFSENSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLP 1541
SPFS+ ST+LQT Q + VQLLQ R+ C WL K SVE+CIR L+ VAK RAI +P
Sbjct: 1493 SPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIP 1552
Query: 1542 MDLDAHISSMLSSGASCAAAAQRNASSYKATTR-AFPRVTPTANQWDYKNIIEKLQDIIT 1600
+DLD+ ++++ S Q+ A +++ + R A R + A DY+NIIE+LQDI++
Sbjct: 1553 VDLDSQVNNLFLKSHS---IVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVS 1609
Query: 1601 ALEERLKPLVQAELSVLVDVLHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLM-ESEE 1659
ALE+RL+PLVQAELSVLVDVLH PELLF E ++A ++CESGGF+ KLI+HTK L+ E+EE
Sbjct: 1610 ALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEE 1669
Query: 1660 KLCIKVLRTLQQMLLKKTKYGDRGNQLRKMLLQNYLQNRKSTSRGDLPDPIGTG------ 1713
KLCIKVL+TL++M+ K YG++G LR++L+ Y N + + R + G G
Sbjct: 1670 KLCIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGG 1729
Query: 1714 ---------------LDPDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAI 1758
+ ++A QC LDKEGA+ LV DLI + ++++F ESI LAI
Sbjct: 1730 PGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAI 1789
Query: 1759 HLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHED 1818
LL+GGNT IQ SF + DKKSE+FFKV +DRMK AQQE K+TV VN +DLG++ +D
Sbjct: 1790 ALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDD 1849
Query: 1819 ---------REPVDPTTK--GRVASFSIPGSSSRYSLGPSLRRGHEVSERVQSS------ 1861
++ +PTT+ V + S++ + RR + + Q
Sbjct: 1850 EVDRDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQAT 1909
Query: 1862 --------EMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDI 1913
EM + IMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLD
Sbjct: 1910 ADKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDC 1969
Query: 1914 MCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITAL 1973
+CGSTTGGLGLLGLYINE NV L+ QTLE+LTEYCQGPCHENQ CI THESNGIDIITAL
Sbjct: 1970 ICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITAL 2029
Query: 1974 ILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAY 2033
ILNDI+PL K RMDLVL+LK+NASKLLLA+MESRHDSENAERIL ++RP+ELV+VIKKAY
Sbjct: 2030 ILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAY 2089
Query: 2034 LQE----EERENSE---VSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGIS 2086
+Q E+ EN E SPR VGHNIYILA QL+RHNK+LQ +LKP ++ +EA
Sbjct: 2090 MQGEVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEA---- 2145
Query: 2087 SMLSLNNKQLSQMLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQF 2146
L +Y HT+QIEIVR DR+MEQIVFPVP IC+F
Sbjct: 2146 ---------------------------LEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEF 2178
Query: 2147 LTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGS 2206
LT+E+K R++ TTE+DEQGSK++DFF +S L NEM WQ+KLR+ P++YW +R M+ W S
Sbjct: 2179 LTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSS 2238
Query: 2207 ISFNLAVFINIIIAFFYPYMEGASTGVLDSPLISLLFW--ILICFSIAALFTKRYSIRPL 2264
ISFNLAV +N+++AFFYP+ +G G L+ P S L W +LI +I K + IR L
Sbjct: 2239 ISFNLAVLMNLLVAFFYPF-KGVRGGTLE-PHWSGLLWTAMLISLAIVIALPKPHGIRAL 2296
Query: 2265 IVALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHV 2324
I + ILR I+ +G+ PTL +LGA N+ NKI+F++SFVGN GTF RGY+AMV+D+EFLYH+
Sbjct: 2297 IASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHL 2356
Query: 2325 GYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFS 2384
Y++ +GLF HE FYS+LLFDL+YREETL NVIKSVTRNGRSI+LTA+LALILVYLFS
Sbjct: 2357 LYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFS 2416
Query: 2385 IVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTC---SGDKMDCVSGLSVPEV 2441
IVG+LF KDDFILEVDRLPN + F D C SG+ +C S E+
Sbjct: 2417 IVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGE--NCSSPAPREEL 2474
Query: 2442 LEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFF 2501
+ + E C+TLLMCIVTV++HGLR+GGGVGD+LRKPSK+E LF ARV+YDLLFF
Sbjct: 2475 VPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFF 2534
Query: 2502 FIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKL 2561
F+VIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTV+FEEHIK
Sbjct: 2535 FMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKE 2594
Query: 2562 EHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNE 2621
EHNMW+YL FIVLV+VK+ T+YTGPESYVA+MIK +NLDWFPRMRAMSLVS++ EGEQNE
Sbjct: 2595 EHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNE 2654
Query: 2622 IRILQDKLNSTMKLVSHLTAQLNELKEQMTEQRKRRQRLGFV 2663
+R LQ+KL STMKLV++L+ QL+ELK+QMTEQRK++QR+G +
Sbjct: 2655 LRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLL 2696
>gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isoform 2
[Homo sapiens]
Length = 2695
Score = 3277 bits (8496), Expect = 0.0
Identities = 1702/2740 (62%), Positives = 2083/2740 (76%), Gaps = 141/2740 (5%)
Query: 3 EMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPM 62
+MSSFLHIGDI SLYAEGS NGFISTLGLVDDRCVV+P GDL+NPPKKFRDCLFK+CPM
Sbjct: 4 KMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPM 63
Query: 63 NRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVI 122
NRYSAQKQ+WKA K D VLL KL HAA +E+KQN+TEN+K+ G V++YG+VI
Sbjct: 64 NRYSAQKQFWKA--AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVI 121
Query: 123 QLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDK 182
QLLH+KSNKYLTVNKRLPALLEKNAMRVTLD GNEGSW +IQPF+KLRS GD+VV+GDK
Sbjct: 122 QLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDK 181
Query: 183 VILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVR 242
V+LNPVNAGQPLHAS+++L DN GC EVNSVNCNTSWKI LFM++ D+ +++LKGGDVVR
Sbjct: 182 VVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVR 241
Query: 243 LFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNG 302
LFHAEQEKFLTCDE++ K VFLRTT RQSATSATSS ALWEVEVV HDPCRGGAG+WN
Sbjct: 242 LFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNS 301
Query: 303 LYRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHGND 362
L+RFKHLATG+YLAAE +P DAS R+ RNA EK+ Y LV+VP GND
Sbjct: 302 LFRFKHLATGHYLAAEVDPDQ--DAS-----------RSRLRNAQEKMVYSLVSVPEGND 348
Query: 363 IASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPT 422
I+S+FELDPTTL+ DS VPRNSYVRLRHLCTNTW+ STN+PID EEE+P+ L +GT P
Sbjct: 349 ISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPV 408
Query: 423 KEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVFF 482
KEDKEAFAIV V +E+RDLDFANDAS +L S KL +G I+QN+RR V +LLEDLV+F
Sbjct: 409 KEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYF 468
Query: 483 VSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGEGPLVRLEELS 542
V+ N+GQ+VL+++ +KPNRERQKLMREQNILKQ+F +L+APF + G+GP++RLEEL
Sbjct: 469 VTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTD-CGDGPMLRLEELG 527
Query: 543 DQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNN 602
DQ++AP++H+ RLCYRVLRHSQ+DYRKNQE+IAKQFG MQ QIGYD+LAEDTITALLHNN
Sbjct: 528 DQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNN 587
Query: 603 RKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNS 662
RKLLEKHIT E++TFVSLVRKNREPRFLDYLSDLCVS + +IPVTQELICK VL+P N+
Sbjct: 588 RKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNA 647
Query: 663 DILIRTELRPVK-----EMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARA 717
DILI T+L + + L EEEVWL W D N E KSVR+LAQ+A+
Sbjct: 648 DILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKE 707
Query: 718 GNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRASF 777
G D +VLSYYRYQL LFARMCLDRQYLAI+EIS QL VDLI CM+DE LP+DLRASF
Sbjct: 708 GQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASF 767
Query: 778 CHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTMEFV 837
C LMLH+HVDRDPQE VTPVK+ARLW+EIP+ I I DYDS+ AS+D+ K +FA TMEFV
Sbjct: 768 CRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSS-GASKDEIKERFAQTMEFV 826
Query: 838 EDYLNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQ- 896
E+YL +VV + PF+++EKNKLTFEVV+LA NLIYFGFY+FS+LLRLT+ LL I+DCV
Sbjct: 827 EEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHV 886
Query: 897 ---GPPAMLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDR 953
P + + E+ G NV RSI GVG +M+ +VL + P A+A E +
Sbjct: 887 TTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPM----AAAPEGNVK 942
Query: 954 SKFEENEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPM--QDSGADG 1011
E EDI+VM+TKLKI+EILQFILNVRLDYRIS LL +FK+EF E + S +
Sbjct: 943 QAEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNS 1002
Query: 1012 TAPAFDSTTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLV 1071
+ + ++ + I EQAE +FG K ++ L++DD GGR FLRVL+HLTMHDY PLV
Sbjct: 1003 SQEGPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLV 1062
Query: 1072 SGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKK 1131
SGALQLLF+HFSQRQE + FKQVQLL+++QDV+NYK IK +LD+LR++VEKSELWV K
Sbjct: 1063 SGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYK- 1121
Query: 1132 GSGKGEEVEAGAAKDKKERPTDEEGFLHPPGEK--SSENYQIVKGILERLNKMC----GV 1185
G+G + A + E EEG P + SS NY++VK IL RL+K+C
Sbjct: 1122 --GQGPDETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESAS 1179
Query: 1186 GEQMRKKQQRLLKNMDAHKVMLDLLQIPYDKG-DAKMMEILRYTHQFLQKFCAGNPGNQA 1244
+ RK+QQRLL+NM AH V+L+LLQIPY+K D KM EI+R H+FLQ FCAGN NQA
Sbjct: 1180 VRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQA 1239
Query: 1245 LLHKHLHLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLH 1304
LLHKH++LFL PG+LEA TMQHIF+NN+QLCSEI+E V+QHFVH + THGR+VQY+ FL
Sbjct: 1240 LLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQ 1299
Query: 1305 TVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMY 1364
T++KAEGK++KKCQDM+M EL N+G+DV+VFYND+AS L+ MM++ RD ++++SPLMY
Sbjct: 1300 TIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMY 1359
Query: 1365 HISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDT 1424
HI LV+LLA C EGKNVYTEIKC SLLPL+D+V VVTHEDCI EVK+AY+NF+NHCYVDT
Sbjct: 1360 HIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDT 1419
Query: 1425 EVEMKEIYTSNHIWTLFENFTLDMARVCSK-REKRVADPTLEKYVLSVVLDTINAFFSSP 1483
EVEMKEIYTSNH+W LFENF +D+ R C+ +++ AD LEKYV +V+ + FFSSP
Sbjct: 1420 EVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSP 1479
Query: 1484 FSENSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMD 1543
FS+ ST+LQT Q + VQLLQ R+ C WL K SVE+CIR L+ VAK RAI +P+D
Sbjct: 1480 FSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVD 1539
Query: 1544 LDAHISSMLSSGASCAAAAQRNASSYKATTR-AFPRVTPTANQWDYKNIIEKLQDIITAL 1602
LD+ ++++ S Q+ A +++ + R A R + A DY+NIIE+LQDI++AL
Sbjct: 1540 LDSQVNNLFLKSHS---IVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSAL 1596
Query: 1603 EERLKPLVQAELSVLVDVLHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLM-ESEEKL 1661
E+RL+PLVQAELSVLVDVLH PELLF E ++A ++CESGGF+ KLI+HTK L+ E+EEKL
Sbjct: 1597 EDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKL 1656
Query: 1662 CIKVLRTLQQMLLKKTKYGDRGNQLRKMLLQNYLQNRKSTSRGDLPDPIGTG-------- 1713
CIKVL+TL++M+ K YG++G LR++L+ Y N + + R + G G
Sbjct: 1657 CIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPG 1716
Query: 1714 -------------LDPDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIHL 1760
+ ++A QC LDKEGA+ LV DLI + ++++F ESI LAI L
Sbjct: 1717 KPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIAL 1776
Query: 1761 LDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHED-- 1818
L+GGNT IQ SF + DKKSE+FFKV +DRMK AQQE K+TV VN +DLG++ +D
Sbjct: 1777 LEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEV 1836
Query: 1819 -------REPVDPTTK--GRVASFSIPGSSSRYSLGPSLRRGHEVSERVQSS-------- 1861
++ +PTT+ V + S++ + RR + + Q
Sbjct: 1837 DRDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATAD 1896
Query: 1862 ------EMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMC 1915
EM + IMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLD +C
Sbjct: 1897 KAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCIC 1956
Query: 1916 GSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALIL 1975
GSTTGGLGLLGLYINE NV L+ QTLE+LTEYCQGPCHENQ CI THESNGIDIITALIL
Sbjct: 1957 GSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALIL 2016
Query: 1976 NDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQ 2035
NDI+PL K RMDLVL+LK+NASKLLLA+MESRHDSENAERIL ++RP+ELV+VIKKAY+Q
Sbjct: 2017 NDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQ 2076
Query: 2036 E----EERENSE---VSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSM 2088
E+ EN E SPR VGHNIYILA QL+RHNK+LQ +LKP ++ +EA
Sbjct: 2077 GEVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEA------ 2130
Query: 2089 LSLNNKQLSQMLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLT 2148
L +Y HT+QIEIVR DR+MEQIVFPVP IC+FLT
Sbjct: 2131 -------------------------LEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLT 2165
Query: 2149 EETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSIS 2208
+E+K R++ TTE+DEQGSK++DFF +S L NEM WQ+KLR+ P++YW +R M+ W SIS
Sbjct: 2166 KESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSIS 2225
Query: 2209 FNLAVFINIIIAFFYPYMEGASTGVLDSPLISLLFW--ILICFSIAALFTKRYSIRPLIV 2266
FNLAV +N+++AFFYP+ +G G L+ P S L W +LI +I K + IR LI
Sbjct: 2226 FNLAVLMNLLVAFFYPF-KGVRGGTLE-PHWSGLLWTAMLISLAIVIALPKPHGIRALIA 2283
Query: 2267 ALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGY 2326
+ ILR I+ +G+ PTL +LGA N+ NKI+F++SFVGN GTF RGY+AMV+D+EFLYH+ Y
Sbjct: 2284 STILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLY 2343
Query: 2327 ILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIV 2386
++ +GLF HE FYS+LLFDL+YREETL NVIKSVTRNGRSI+LTA+LALILVYLFSIV
Sbjct: 2344 LVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIV 2403
Query: 2387 GFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTC---SGDKMDCVSGLSVPEVLE 2443
G+LF KDDFILEVDRLPN + F D C SG+ +C S E++
Sbjct: 2404 GYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGE--NCSSPAPREELVP 2461
Query: 2444 EDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFI 2503
+ E C+TLLMCIVTV++HGLR+GGGVGD+LRKPSK+E LF ARV+YDLLFFF+
Sbjct: 2462 AEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFM 2521
Query: 2504 VIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEH 2563
VIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTV+FEEHIK EH
Sbjct: 2522 VIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEH 2581
Query: 2564 NMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIR 2623
NMW+YL FIVLV+VK+ T+YTGPESYVA+MIK +NLDWFPRMRAMSLVS++ EGEQNE+R
Sbjct: 2582 NMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNELR 2641
Query: 2624 ILQDKLNSTMKLVSHLTAQLNELKEQMTEQRKRRQRLGFV 2663
LQ+KL STMKLV++L+ QL+ELK+QMTEQRK++QR+G +
Sbjct: 2642 NLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLL 2681
>gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens]
Length = 4967
Score = 162 bits (410), Expect = 4e-39
Identities = 92/287 (32%), Positives = 152/287 (52%), Gaps = 49/287 (17%)
Query: 2317 DMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLA 2376
D FLY Y+ SVLG + + F++ L D+ +TL ++ SVT NG+ ++LT L
Sbjct: 4716 DNSFLYLAWYMTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLL 4774
Query: 2377 LILVYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGL 2436
++VYL+++V F F + +
Sbjct: 4775 AVVVYLYTVVAFNFFRKFY----------------------------------------- 4793
Query: 2437 SVPEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVY 2496
+ + D+ + CD +L C + M G+R GGG+GD + P+ DE R+++
Sbjct: 4794 ------NKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEI-YRIIF 4846
Query: 2497 DLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFE 2556
D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD FE
Sbjct: 4847 DITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFE 4906
Query: 2557 EHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFP 2603
H EHN+ NYL+F++ + K++T++TG ESYV +M + + ++FP
Sbjct: 4907 THTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP 4953
Score = 89.4 bits (220), Expect = 4e-17
Identities = 156/692 (22%), Positives = 264/692 (38%), Gaps = 96/692 (13%)
Query: 84 IADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVK-----------------YGSVIQLLH 126
I VL Q L A E N E + DV K YG I L H
Sbjct: 64 ICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRH 123
Query: 127 MKSNKYLTVNKRLPALLEKNAMRVTL--DATGNEGSWLFIQPFWKLRSNGDNVVVGDKVI 184
S YL + +K A V L D TG E W I P K RS G+ V VGD +I
Sbjct: 124 SYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTG-EACWWTIHPASKQRSEGEKVRVGDDLI 182
Query: 185 LNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVRLF 244
L V++ + LH LS G V++ T W + + + L GGDV+RL
Sbjct: 183 LVSVSSERYLH-----LSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLL 237
Query: 245 HAEQEKFLTCDEYK-GKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGL 303
H ++ LT + G+ Q RT + + + +LW +E + G W
Sbjct: 238 HGHMDECLTVPSGEHGEEQ--RRTVHYEGGAVSVHARSLWRLETL-RVAWSGSHIRWGQP 294
Query: 304 YRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHGNDI 363
+R +H+ TG YL+ E+ + D + A + + T R++ EK+ D+
Sbjct: 295 FRLRHVTTGKYLSLMEDKNLL--LMDKEKADVKSTAFT-FRSSKEKL-----------DV 340
Query: 364 ASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTK 423
E+D T +S ++H+ T W+ T +D++ R +G+ K
Sbjct: 341 GVRKEVDG---MGTSEIKYGDSVCYIQHVDTGLWL--TYQSVDVKSVR-----MGSIQRK 390
Query: 424 EDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNE-----GFISQNDRRFVIQL--- 475
+ +S R + + ++ S V N +S+ + + L
Sbjct: 391 AIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIE 450
Query: 476 -----LEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGIL-------- 522
L+DL+ + + ++ + + RQ L +E+ ++ V +
Sbjct: 451 SVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSS 510
Query: 523 KAPFREKGGEGPLVRLEELSDQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQ 582
A F + G + ++ + Y +L RKN + +
Sbjct: 511 AAHFADVAGR-----------EAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLI 559
Query: 583 SQIGYDILAEDTITALLHNNRKLLEKH-----ITKTEVETFVSLVRKN-REPRFLDYLSD 636
S++ + A I +LH L+E I + +++ +SL+ K+ R + LD L
Sbjct: 560 SRL-ERLEASSGILEVLH--CVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCS 616
Query: 637 LCVSNHIAIPVTQELICKCVLDPKNSDILIRTELRPVKEMAQSHEYLSIEYSEEEVWLTW 696
LCV + +A+ Q LIC +L + D+L++T L + + +L + + +
Sbjct: 617 LCVCHGVAVRSNQHLICDNLLPGR--DLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWY 674
Query: 697 TDKNNEHHEKSVRQLAQEARAGNAHDENVLSY 728
+ +H E V A R G A E Y
Sbjct: 675 YELMVDHTEPFVTAEATHLRVGWASTEGYSPY 706
Score = 66.6 bits (161), Expect = 3e-10
Identities = 67/244 (27%), Positives = 105/244 (43%), Gaps = 51/244 (20%)
Query: 1725 QCRLDKEGATKLVCDLITSTKNEK--IFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKS 1782
Q RL GA ++V I+++K E + ++ L I +L+GGN+ +Q+ + + +KK
Sbjct: 3728 QARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYL-KEKKD 3786
Query: 1783 ERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRY 1842
FF+ L M+ + ++ DL + +++
Sbjct: 3787 VGFFQSLAGLMQ----------SCSVLDLNAFERQNKAE--------------------- 3815
Query: 1843 SLGPSLRRGHEVSERVQSSEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQ-NNKTNY 1901
LG G E+V + T L RFLQLLCE HN D QN+LR Q N T
Sbjct: 3816 GLGMVTEEGS--GEKVLQDDEFTCDLF-----RFLQLLCEGHNSDFQNYLRTQTGNNTTV 3868
Query: 1902 NLVCETLQFLDIMCGSTT------GGLGLL---GLYINEDNVGLVIQTLETLTEYCQGPC 1952
N++ T+ +L + S + G ++ G + + Q TLTEY QGPC
Sbjct: 3869 NIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPC 3928
Query: 1953 HENQ 1956
NQ
Sbjct: 3929 TGNQ 3932
>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
sapiens]
Length = 5033
Score = 161 bits (407), Expect = 9e-39
Identities = 92/288 (31%), Positives = 154/288 (53%), Gaps = 51/288 (17%)
Query: 2317 DMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLA 2376
D FLY Y++ S+LG + + F++ L D+ +TL ++ SVT NG+ +++T L
Sbjct: 4782 DNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLL 4840
Query: 2377 LILVYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGL 2436
++VYL+++V F F + +
Sbjct: 4841 AVVVYLYTVVAFNFFRKFY----------------------------------------- 4859
Query: 2437 SVPEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDE-SLFPARVV 2495
+ + D + CD ++ C + M G+R GGG+GD + P+ DE L+ RVV
Sbjct: 4860 ------NKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELY--RVV 4911
Query: 2496 YDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSF 2555
+D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD F
Sbjct: 4912 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGF 4971
Query: 2556 EEHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFP 2603
E H EHN+ NY++F++ + K++T++TG ESYV +M + + D+FP
Sbjct: 4972 ETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5019
Score = 88.2 bits (217), Expect = 1e-16
Identities = 137/589 (23%), Positives = 233/589 (39%), Gaps = 90/589 (15%)
Query: 118 YGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTL--DATGNEGSWLFIQPFWKLRSNGD 175
YG I L H S YL+ ++ +K A V L DATG E W + P K RS G+
Sbjct: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATG-EACWWTMHPASKQRSEGE 160
Query: 176 NVVVGDKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVL 235
V VGD +IL V++ + LH LS +G +V++ T W +N + E +
Sbjct: 161 KVRVGDDIILVSVSSERYLH-----LSTASGELQVDASFMQTLWNMNPICSRCE--EGFV 213
Query: 236 KGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRG 295
GG V+RLFH ++ LT Q R + T + +LW +E + G
Sbjct: 214 TGGHVLRLFHGHMDECLTISPADSDDQ--RRLVYYEGGAVCTHARSLWRLEPLRIS-WSG 270
Query: 296 GAGHWNGLYRFKHLATGNYLA-AEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCL 354
W R +H+ TG YLA E+ DAS + +C
Sbjct: 271 SHLRWGQPLRVRHVTTGQYLALTEDQGLVVVDASKAHT---------------KATSFCF 315
Query: 355 VAVPHGNDIASLFELD---PTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEER 411
D+A +++ P ++ +S ++H+ + W+ T D
Sbjct: 316 RISKEKLDVAPKRDVEGMGPPEIKYGESLC------FVQHVASGLWL--TYAAPD----- 362
Query: 412 PIRLMLGTCPTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDR-- 469
P L LG K + +S R + A+ M+ S N+ FI D
Sbjct: 363 PKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQ-FIKSLDSFS 421
Query: 470 ----------------RFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKLMREQN 513
VI L+DL+ + + Q+ + R RQ L +E+
Sbjct: 422 GKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEEG 481
Query: 514 ILKQVFGILK--------APFREKGGEGPLVRLEELSDQKNAPYQHMFRLCYRVLRHSQE 565
+L V + A F E GE +E+ + ++ L ++R ++
Sbjct: 482 MLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNL-------LYELLASLIRGNRS 534
Query: 566 D---YRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLV 622
+ + N + + + +++ G + E L+ + L I + +++ +SL+
Sbjct: 535 NCALFSTNLDWLVSKLDRLEASSG---ILEVLYCVLIESPEVL--NIIQENHIKSIISLL 589
Query: 623 RKN-REPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIRTEL 670
K+ R + LD L LCV N +A+ Q+LI + +L + ++L++T L
Sbjct: 590 DKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGR--ELLLQTNL 636
Score = 72.4 bits (176), Expect = 6e-12
Identities = 68/247 (27%), Positives = 108/247 (43%), Gaps = 51/247 (20%)
Query: 1725 QCRLDKEGATKLVCDLITSTKNEK--IFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKS 1782
Q RL GA ++V +I++ K E + ++ L I +L+GGN E+Q+ + + DKK
Sbjct: 3761 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYL-KDKKE 3819
Query: 1783 ERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRY 1842
FF+ + +A +T S + +N + ++ G
Sbjct: 3820 VGFFQSI-----QALMQTCSVLDLNAFERQNKAE--------------------GLGMVN 3854
Query: 1843 SLGPSLRRGHEVSERVQSSEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQ-NNKTNY 1901
G + R + E+V + + T Q + RFLQLLCE HN D QN+LR Q N T
Sbjct: 3855 EDGTVINRQN--GEKVMADDEFT-----QDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTI 3907
Query: 1902 NLVCETLQFLDIMCGSTTGGLGLLGLYINEDNV------------GLVIQTLETLTEYCQ 1949
N++ T+ +L + S + Y +D + + Q +LTEY Q
Sbjct: 3908 NIIICTVDYLLRLQESIS---DFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQ 3964
Query: 1950 GPCHENQ 1956
GPC NQ
Sbjct: 3965 GPCTGNQ 3971
Score = 37.7 bits (86), Expect = 0.15
Identities = 29/109 (26%), Positives = 51/109 (46%), Gaps = 6/109 (5%)
Query: 1223 EILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTP-GLLEA-----ETMQHIFLNNYQLCS 1276
EI+ ++ L GN N AL +L ++ LEA E + + + + ++ +
Sbjct: 516 EIVNLLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLN 575
Query: 1277 EISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDMIMTEL 1325
I E ++ + LL HGR+ + LD L ++ G V+ QD+I L
Sbjct: 576 IIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENL 624
>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
Length = 5038
Score = 161 bits (407), Expect = 9e-39
Identities = 92/288 (31%), Positives = 154/288 (53%), Gaps = 51/288 (17%)
Query: 2317 DMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLA 2376
D FLY Y++ S+LG + + F++ L D+ +TL ++ SVT NG+ +++T L
Sbjct: 4787 DNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLL 4845
Query: 2377 LILVYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGL 2436
++VYL+++V F F + +
Sbjct: 4846 AVVVYLYTVVAFNFFRKFY----------------------------------------- 4864
Query: 2437 SVPEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDE-SLFPARVV 2495
+ + D + CD ++ C + M G+R GGG+GD + P+ DE L+ RVV
Sbjct: 4865 ------NKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELY--RVV 4916
Query: 2496 YDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSF 2555
+D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD F
Sbjct: 4917 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGF 4976
Query: 2556 EEHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFP 2603
E H EHN+ NY++F++ + K++T++TG ESYV +M + + D+FP
Sbjct: 4977 ETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5024
Score = 88.2 bits (217), Expect = 1e-16
Identities = 137/589 (23%), Positives = 233/589 (39%), Gaps = 90/589 (15%)
Query: 118 YGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTL--DATGNEGSWLFIQPFWKLRSNGD 175
YG I L H S YL+ ++ +K A V L DATG E W + P K RS G+
Sbjct: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATG-EACWWTMHPASKQRSEGE 160
Query: 176 NVVVGDKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVL 235
V VGD +IL V++ + LH LS +G +V++ T W +N + E +
Sbjct: 161 KVRVGDDIILVSVSSERYLH-----LSTASGELQVDASFMQTLWNMNPICSRCE--EGFV 213
Query: 236 KGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRG 295
GG V+RLFH ++ LT Q R + T + +LW +E + G
Sbjct: 214 TGGHVLRLFHGHMDECLTISPADSDDQ--RRLVYYEGGAVCTHARSLWRLEPLRIS-WSG 270
Query: 296 GAGHWNGLYRFKHLATGNYLA-AEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCL 354
W R +H+ TG YLA E+ DAS + +C
Sbjct: 271 SHLRWGQPLRVRHVTTGQYLALTEDQGLVVVDASKAHT---------------KATSFCF 315
Query: 355 VAVPHGNDIASLFELD---PTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEER 411
D+A +++ P ++ +S ++H+ + W+ T D
Sbjct: 316 RISKEKLDVAPKRDVEGMGPPEIKYGESLC------FVQHVASGLWL--TYAAPD----- 362
Query: 412 PIRLMLGTCPTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDR-- 469
P L LG K + +S R + A+ M+ S N+ FI D
Sbjct: 363 PKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQ-FIKSLDSFS 421
Query: 470 ----------------RFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKLMREQN 513
VI L+DL+ + + Q+ + R RQ L +E+
Sbjct: 422 GKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEEG 481
Query: 514 ILKQVFGILK--------APFREKGGEGPLVRLEELSDQKNAPYQHMFRLCYRVLRHSQE 565
+L V + A F E GE +E+ + ++ L ++R ++
Sbjct: 482 MLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNL-------LYELLASLIRGNRS 534
Query: 566 D---YRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLV 622
+ + N + + + +++ G + E L+ + L I + +++ +SL+
Sbjct: 535 NCALFSTNLDWLVSKLDRLEASSG---ILEVLYCVLIESPEVL--NIIQENHIKSIISLL 589
Query: 623 RKN-REPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIRTEL 670
K+ R + LD L LCV N +A+ Q+LI + +L + ++L++T L
Sbjct: 590 DKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGR--ELLLQTNL 636
Score = 72.4 bits (176), Expect = 6e-12
Identities = 68/247 (27%), Positives = 108/247 (43%), Gaps = 51/247 (20%)
Query: 1725 QCRLDKEGATKLVCDLITSTKNEK--IFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKS 1782
Q RL GA ++V +I++ K E + ++ L I +L+GGN E+Q+ + + DKK
Sbjct: 3766 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYL-KDKKE 3824
Query: 1783 ERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRY 1842
FF+ + +A +T S + +N + ++ G
Sbjct: 3825 VGFFQSI-----QALMQTCSVLDLNAFERQNKAE--------------------GLGMVN 3859
Query: 1843 SLGPSLRRGHEVSERVQSSEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQ-NNKTNY 1901
G + R + E+V + + T Q + RFLQLLCE HN D QN+LR Q N T
Sbjct: 3860 EDGTVINRQN--GEKVMADDEFT-----QDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTI 3912
Query: 1902 NLVCETLQFLDIMCGSTTGGLGLLGLYINEDNV------------GLVIQTLETLTEYCQ 1949
N++ T+ +L + S + Y +D + + Q +LTEY Q
Sbjct: 3913 NIIICTVDYLLRLQESIS---DFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQ 3969
Query: 1950 GPCHENQ 1956
GPC NQ
Sbjct: 3970 GPCTGNQ 3976
Score = 37.7 bits (86), Expect = 0.15
Identities = 29/109 (26%), Positives = 51/109 (46%), Gaps = 6/109 (5%)
Query: 1223 EILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTP-GLLEA-----ETMQHIFLNNYQLCS 1276
EI+ ++ L GN N AL +L ++ LEA E + + + + ++ +
Sbjct: 516 EIVNLLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLN 575
Query: 1277 EISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDMIMTEL 1325
I E ++ + LL HGR+ + LD L ++ G V+ QD+I L
Sbjct: 576 IIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENL 624
>gi|126032338 ryanodine receptor 3 [Homo sapiens]
Length = 4870
Score = 160 bits (405), Expect = 2e-38
Identities = 96/287 (33%), Positives = 151/287 (52%), Gaps = 49/287 (17%)
Query: 2317 DMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLA 2376
D FLY Y SVLG + + F++ L D+ +TL ++ SVT NG+ ++LT L
Sbjct: 4619 DNSFLYLAWYTTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLL 4677
Query: 2377 LILVYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGL 2436
++VYL+++V F F + + N S
Sbjct: 4678 AVVVYLYTVVAFNFFRKFY---------NKS----------------------------- 4699
Query: 2437 SVPEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVY 2496
E+D D + CD ++ C + M G+R GGG+GD + P+ D R+V+
Sbjct: 4700 ------EDD---DEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEM-YRIVF 4749
Query: 2497 DLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFE 2556
D+ FFF VI+I+L +I G+IID F +LR ++++ E ++T CFICG+ D FD FE
Sbjct: 4750 DITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFE 4809
Query: 2557 EHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFP 2603
H EHN+ NYL+F++ + K++T++TG ESYV +M + + D+FP
Sbjct: 4810 THTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 4856
Score = 95.9 bits (237), Expect = 5e-19
Identities = 141/622 (22%), Positives = 245/622 (39%), Gaps = 86/622 (13%)
Query: 84 IADVVLLQKLQHAAQMEQKQNDTENK---KVHGD---VVKYGSVIQLLHMKSNKYLTVNK 137
+ + VL Q L A E N EN G + YG + L H S YLT
Sbjct: 65 VCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYLTCLT 124
Query: 138 RLPALLEKNAMRVTL--DATGNEGSWLFIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLH 195
+ +K A V L ATG E W I P K RS G+ V +GD +IL V++ + LH
Sbjct: 125 TSRSQTDKLAFDVGLREHATG-EACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLH 183
Query: 196 ASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCD 255
LS + G +V++ T W ++ E L GG VVRLFH E
Sbjct: 184 -----LSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPS 238
Query: 256 EYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNYL 315
+ Q R ++ + T + +LW VE + G W +R +HL TG+YL
Sbjct: 239 TDQNDSQ--HRRIFYEAGGAGTRARSLWRVEPLRIS-WSGSNIRWGQAFRLRHLTTGHYL 295
Query: 316 AAEENPS---YKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPT 372
A E+ SD K+ + A +++K L + H DI +
Sbjct: 296 ALTEDQGLILQDRAKSDTKSTAFSFR-------ASKELKEKLDS-SHKRDIEGM------ 341
Query: 373 TLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIR--------------LMLG 418
+S ++H+ + W+ P++ L L
Sbjct: 342 ---GVPEIKYGDSVCFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQ 398
Query: 419 TCPTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLED 478
C +E + A I + + + N ++ + +E+ V+Q L+D
Sbjct: 399 RCQREESQAARIIRNTTALFSQFVSGNNRTAAPITLPIEE-------------VLQTLQD 445
Query: 479 LVFFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKA--PFREKGGEGPLV 536
L+ + ++ + + RQ L +E+ +L V + + +
Sbjct: 446 LIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYNSVAHFAGIA 505
Query: 537 RLEELSDQKNAPYQHMFRLCYRVL-------RHSQEDYRKNQEHIAKQFGMMQSQIGYDI 589
R ++ ++ + L Y++L R++ + N + + + ++S G I
Sbjct: 506 R-----EESGMAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSG--I 558
Query: 590 LAEDTITALLHNNRKLLEKHITKTEVETFVSLVRKN-REPRFLDYLSDLCVSNHIAIPVT 648
L + + +L + + L I + +++ +SL+ K+ R + LD L LC+ N +A+
Sbjct: 559 L--EVLHCILTESPEALNL-IAEGHIKSIISLLDKHGRNHKVLDILCSLCLCNGVAVRAN 615
Query: 649 QELICKCVLDPKNSDILIRTEL 670
Q LIC +L +N +L++T L
Sbjct: 616 QNLICDNLLPRRN--LLLQTRL 635
Score = 72.4 bits (176), Expect = 6e-12
Identities = 68/248 (27%), Positives = 111/248 (44%), Gaps = 53/248 (21%)
Query: 1725 QCRLDKEGATKLVCDLITSTKNEK--IFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKS 1782
Q RL + GA ++V +I+++K E + E++ L I +L+GGN +Q+ + + +KK
Sbjct: 3618 QARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYL-KEKKD 3676
Query: 1783 ERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRY 1842
FF+ L M+ + ++ DL + +++
Sbjct: 3677 AGFFQSLSGLMQ----------SCSVLDLNAFERQNKAE--------------------- 3705
Query: 1843 SLGPSLRRG----HEVSERVQSSEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQ-NN 1897
LG G E E+V ++ T + + RFLQLLCE HN D QNFLR Q N
Sbjct: 3706 GLGMVTEEGTLIVRERGEKVLQNDEFT-----RDLFRFLQLLCEGHNSDFQNFLRTQMGN 3760
Query: 1898 KTNYNLVCETLQFLDIMCGSTT------GGLGLL---GLYINEDNVGLVIQTLETLTEYC 1948
T N++ T+ +L + S + G ++ G + + + Q +LTEY
Sbjct: 3761 TTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYI 3820
Query: 1949 QGPCHENQ 1956
QGPC NQ
Sbjct: 3821 QGPCIGNQ 3828
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 38.9 bits (89), Expect = 0.069
Identities = 50/214 (23%), Positives = 88/214 (41%), Gaps = 18/214 (8%)
Query: 1989 VLQLKDNASKLLLALMESRHDSENAERILISLRP---------QELVDVIKKAYLQEEER 2039
+LQ K + LL+A E ER L +L+ + +D +K+ Y + E
Sbjct: 732 LLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQY--DAEL 789
Query: 2040 ENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEE--EAEGISSMLSLNNKQLS 2097
+ S E N+ +LA + + + VK +QEE + +G S L QL
Sbjct: 790 QALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQ 849
Query: 2098 QMLKSSAPAQEEEEDPLAYYENHTSQIE--IVRQDRSMEQIVFPVPGICQFLTEETKHRL 2155
+ ++ + + ++ L YE Q+E +V + ++ V + L +
Sbjct: 850 RQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLS 909
Query: 2156 FTTTEQDEQGSKVSDFFDQSSFLH---NEMEWQR 2186
TT EQ + K+ + +Q L NEME +R
Sbjct: 910 QTTQEQKQLSEKLKEESEQKEQLRRLKNEMENER 943
Score = 36.6 bits (83), Expect = 0.34
Identities = 49/205 (23%), Positives = 84/205 (40%), Gaps = 28/205 (13%)
Query: 1985 RMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERENSEV 2044
R LV Q++D S+L + L E R++S+ L+S R I ++ Q E+ N +
Sbjct: 1059 RSRLVKQMEDKVSQLEMELEEERNNSD-----LLSER-------ISRSREQMEQLRNELL 1106
Query: 2045 SPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLKSSA 2104
R ++ + L R NK L+ + ++ EG+ + +L L+S
Sbjct: 1107 QERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLES-- 1164
Query: 2105 PAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKH---RLFTTTEQ 2161
EE D Q+ R +R ++++V V LT++ RL Q
Sbjct: 1165 ----EERD------RANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQ 1214
Query: 2162 DEQGSKVSDFFDQS-SFLHNEMEWQ 2185
E+ + D + S L E+E Q
Sbjct: 1215 VEEAEEEIDRLESSKKKLQRELEEQ 1239
>gi|56550043 sarcolemma associated protein [Homo sapiens]
Length = 811
Score = 38.1 bits (87), Expect = 0.12
Identities = 52/200 (26%), Positives = 82/200 (41%), Gaps = 30/200 (15%)
Query: 1991 QLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERENSEVSPREVG 2050
Q +D+ K L+AL E +H+ E + + QE ++V++K L E ER
Sbjct: 231 QTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRK--LSEVER----------- 277
Query: 2051 HNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNN--KQLSQMLKSSAPAQE 2108
LS + HL + +R QEE E + N K LS LK A ++
Sbjct: 278 --------SLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLK-VAEGKQ 328
Query: 2109 EEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTTTEQDEQGSKV 2168
EE E Q +I + +++ + + Q + T RL T Q+ SK
Sbjct: 329 EEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEAL-QADNDFTNERL--TALQEHLLSKS 385
Query: 2169 SDFFDQSSFLHNEMEWQRKL 2188
+F+H +E Q+KL
Sbjct: 386 G---GDCTFIHQFIECQKKL 402
>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
Length = 946
Score = 37.0 bits (84), Expect = 0.26
Identities = 71/374 (18%), Positives = 135/374 (36%), Gaps = 39/374 (10%)
Query: 883 RLTRTLLGIIDCVQGPPAMLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLS 942
+L LL ++ +Q QAY S+ + K++ S P+ +
Sbjct: 152 QLQDELLEVVSELQTAKKTYQAYH-------MESVNAEAKLREAERQEEKRAGRSVPTTT 204
Query: 943 AGASAAEPLDRSKFEENEDIVVMETKLKILEILQFILNVRLDYRISYL---LSVFKKEFV 999
AGA+ A PL +S ++ + V + + K +E R +Y +S +V
Sbjct: 205 AGATEAGPLRKSSLKKGGRL-VEKRQAKFMEHKLKCTKARNEYLLSLASVNAAVSNYYLH 263
Query: 1000 EVFPMQDSGADGTAPAFDSTTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVL 1059
+V + D G A + QA + G+G +E D G +
Sbjct: 264 DVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQGLGSLEEAVEALDPPGDKAKVLE 323
Query: 1060 IHLTM------HDYAPLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSE 1113
+H T+ DY P + + R E + + +Q + Q +E +V K+
Sbjct: 324 VHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILPRAQNIQSRLDRQTIETEEVNKTL 383
Query: 1114 LDRLRTMVEKSELWVDKKGSGKGEEVEAGAAKDKKE--RPTDEEGFLHPPGEKSSENYQI 1171
L+ ++E S G+ +++ E + T + G + + +
Sbjct: 384 KATLQALLE-------VVASDDGDVLDSFQTSPSTESLKSTSSDPGSRQAGRRRGQQQET 436
Query: 1172 VKGILERLNKMCGVGEQMRKKQQRLLKNMDAHKVMLDLLQIPYDKGDAKMMEI--LRYTH 1229
L +L + + K Q + H+ + + LQ +GD + E+ +YT
Sbjct: 437 ETFYLTKLQEYLSGRSILAKLQAK-------HEKLQEALQ----RGDKEEQEVSWTQYTQ 485
Query: 1230 QFLQKFCAGNPGNQ 1243
+ QK P +Q
Sbjct: 486 RKFQKSRQPRPSSQ 499
>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
subunit [Homo sapiens]
Length = 2339
Score = 36.6 bits (83), Expect = 0.34
Identities = 62/254 (24%), Positives = 102/254 (40%), Gaps = 41/254 (16%)
Query: 2295 VFVVSFVGNRGTFIR-GYKAMVMDMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREE 2353
+ + FV ++G+++R G+ M +F+ +LT +L + L + R
Sbjct: 149 IIALGFVFHKGSYLRNGWNVM----DFVV----VLTGILATAGTDFDLRTLRAVRVLRPL 200
Query: 2354 TLFN-------VIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVDRLPNNH 2406
L + V+KS+ + +L LL + +F+I+G F F PN+
Sbjct: 201 KLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKAC--FPNS- 257
Query: 2407 STASPLG-MPHGAAAFVDTCSGDKMDCVSGLSVPEVLEEDRELDSTERACDTLLMCIVTV 2465
+ A P+G P G A C GD +C P + D +L I+TV
Sbjct: 258 TDAEPVGDFPCGKEAPARLCEGDT-ECREYWPGPNFGITN---------FDNILFAILTV 307
Query: 2466 MNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIII----VLNLIFGVIIDTFA 2521
G DIL + A ++ L+F +III +LNL+ GV+ FA
Sbjct: 308 FQCITMEGWT--DILYNTND-----AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA 360
Query: 2522 DLRSEKQKKEEILK 2535
R + + LK
Sbjct: 361 KERERVENRRAFLK 374
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 36.2 bits (82), Expect = 0.44
Identities = 43/197 (21%), Positives = 86/197 (43%), Gaps = 25/197 (12%)
Query: 1963 ESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLA---LMESRHDSENAERILIS 2019
++ D + + +D S + K +L +LK ++++ + + + E+ +L +
Sbjct: 1491 QNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKN 1550
Query: 2020 LRPQELVD----VIKKAYLQE--EERENSEVSPRE----VGHNIYILALQLSRHNKQLQH 2069
Q+ ++ V K + QE EE++N E + + +Y + +L K+L+H
Sbjct: 1551 YNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEH 1610
Query: 2070 LLKPVKRIQEE--------EAEGISSMLSLNNK--QLSQMLKSSAPAQ--EEEEDPLAYY 2117
+ VK +EE E+E + + L K Q +K +Q E+EE
Sbjct: 1611 VNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGT 1670
Query: 2118 ENHTSQIEIVRQDRSME 2134
E+H S++ Q+R E
Sbjct: 1671 ESHLSELNTKLQERERE 1687
>gi|157266264 pleckstrin homology-like domain, family B, member 3
[Homo sapiens]
Length = 640
Score = 35.0 bits (79), Expect = 0.99
Identities = 30/135 (22%), Positives = 60/135 (44%), Gaps = 10/135 (7%)
Query: 1981 LCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERE 2040
L K + L Q +D +LL + E R + A+R L Q+L + ++EE +
Sbjct: 197 LRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQL-----ERESRQEEED 251
Query: 2041 NSEVSPREVGHNIYILALQLSRHNK-QLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQM 2099
P+ + L +++H + LQH + R+ EE+ + + ++ ++ LS+
Sbjct: 252 RDSPGPQVPDPKVQELQASMAQHRRGALQHRI----RVLEEQLKSLGEQMAAESRGLSRK 307
Query: 2100 LKSSAPAQEEEEDPL 2114
+ + A +E L
Sbjct: 308 KEEALQALSQERSRL 322
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 34.3 bits (77), Expect = 1.7
Identities = 51/222 (22%), Positives = 99/222 (44%), Gaps = 25/222 (11%)
Query: 1981 LCKYRMDL--VLQLKDNASKLLLAL-MESRHDSENAERILISL--RPQELVDVIKKAY-- 2033
L +YR DL V+ +KD+ K LL + ++ + EN L +E + +++++
Sbjct: 2533 LIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNA 2592
Query: 2034 LQEEERENSEVSPREVGHNIYILALQLSRHNKQLQH-----LLKPVKRIQEEEAEGISSM 2088
LQEE+++ S +E+ ++ + QL+R LQ L +++EEE +S++
Sbjct: 2593 LQEEKQDLS----KEI-ESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSAL 2647
Query: 2089 LSLNNKQLSQM-------LKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVP 2141
S + K+++++ K +A E ED L H + ++ + E V
Sbjct: 2648 FSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNET-ETAEERVA 2706
Query: 2142 GICQFLTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEME 2183
+ + L E + L T E +++ F S L N +
Sbjct: 2707 ELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRD 2748
Score = 32.3 bits (72), Expect = 6.4
Identities = 39/175 (22%), Positives = 75/175 (42%), Gaps = 18/175 (10%)
Query: 1491 LQTHQ--TIVVQLLQSTTRLLECPWLQQQH-----KGSVEACIRTLAMVAKGRAILLPMD 1543
LQ +Q T Q++Q R W + H K S E R + K + ++ D
Sbjct: 2921 LQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRM----KEQYLMAISD 2976
Query: 1544 LD---AHISSMLSSGASCAAAAQRNASSYKATTRAFPRVTPTANQWDYKNIIEKLQDIIT 1600
D +H+ +++ S ++ Q Y+ +P +Q N++ + + + T
Sbjct: 2977 KDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQ----NLVYETELLRT 3032
Query: 1601 ALEERLKPLVQAELSVLVDVLHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLM 1655
L + LK + Q EL + ++ +LL + + + Q C++ L + QH DL+
Sbjct: 3033 QLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLL 3087
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 33.9 bits (76), Expect = 2.2
Identities = 32/128 (25%), Positives = 59/128 (46%), Gaps = 9/128 (7%)
Query: 465 SQNDRRFVIQLLEDLVFFVSDVPNNGQ-NVLDIMVTKPNRERQKLMREQNILKQVFGILK 523
++ +R + L++ L + D NN Q NV ++ + E L+ N + Q +
Sbjct: 1347 AKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQS--EHDTLLERHNKMLQETVSKE 1404
Query: 524 APFREK----GGEGPLVRLEELSDQKNAPYQH-MFRLCYR-VLRHSQEDYRKNQEHIAKQ 577
A REK E +++ E Q+ + R +R +RH QE++RK E + +Q
Sbjct: 1405 AELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQ 1464
Query: 578 FGMMQSQI 585
M++Q+
Sbjct: 1465 LSKMEAQL 1472
Score = 33.1 bits (74), Expect = 3.8
Identities = 108/563 (19%), Positives = 225/563 (39%), Gaps = 75/563 (13%)
Query: 1582 TANQWDYKNIIEKL---QDIITALEERLKPLVQAELSVLVDVLHWPELLF-LEGSEAYQR 1637
T N+ +N EKL Q+++ LE +K L + L+ + +L LEG
Sbjct: 536 TVNRLQGEN--EKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLT 593
Query: 1638 CESGGFLSKLIQHTKDL------MESEEKLCIKVLRTLQQMLLKKTKYGDRGNQLRKMLL 1691
E F++KL +++ E EE+L +++ + ++Q + ++ + N+L L
Sbjct: 594 EEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLE 653
Query: 1692 QNYLQNRKSTSRGDLPDPIGTGLDPDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIF- 1750
+ + ++ + + L D ++A L +E KL + +++ ++F
Sbjct: 654 ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEEN-NKLSSEKKQLSRDLEVFL 712
Query: 1751 --QESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQETKSTVAVNM 1808
+E + L H+ T+++K L + ++ + K+L + + + K+ + +
Sbjct: 713 SQKEDVILKEHI-----TQLEKK---LQLMVEEQDNLNKLLENEQVQ-KLFVKTQLYGFL 763
Query: 1809 NDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRYSLGPSLRRGHEVSERVQSSEMGTSVL 1868
++GS+ ED E D + ++G SL + +E + + + VL
Sbjct: 764 KEMGSEVSEDSEEKDVV-------------NVLQAVGESLAKINEEKCNL-AFQRDEKVL 809
Query: 1869 IMQPILRFLQLLCENHNRDLQNFLR-CQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGL 1927
++ ++ LQ +L++ LR + K E +Q S +
Sbjct: 810 ELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANE 869
Query: 1928 YINEDNVGLVIQTLETLTEYCQGPCH-ENQTCIVTHESNGIDIITALILNDISPLCKYRM 1986
+N L+IQ E + H E + C + N + PL + +
Sbjct: 870 KTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHEN------------LKPLLEQK- 916
Query: 1987 DLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERENSEVSP 2046
+L+D ++L+L L +S S + + D + EE+ EN E
Sbjct: 917 ----ELRDRRAELIL-LKDSLAKSPSVKN-----------DPLSSVKELEEKIENLEKEC 960
Query: 2047 REVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLKSSAPA 2106
+E I + L + K+L K + ++EE + S+ S QLS ++
Sbjct: 961 KEKEEKINKIKLVAVKAKKELDSSRKETQTVKEE----LESLRS-EKDQLSASMRDLIQG 1015
Query: 2107 QEEEEDPLAYYENHTSQIEIVRQ 2129
E ++ L YE + Q+++ ++
Sbjct: 1016 AESYKNLLLEYEKQSEQLDVEKE 1038
>gi|219689136 coiled-coil domain containing 68 [Homo sapiens]
Length = 335
Score = 33.9 bits (76), Expect = 2.2
Identities = 32/127 (25%), Positives = 61/127 (48%), Gaps = 8/127 (6%)
Query: 2031 KAYLQEEERENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLS 2090
K LQ + E + + V N+ +A +L + Q+ L V+R+++E+ + LS
Sbjct: 153 KQLLQVNKLEKEQKLKQHV-ENLNQVAEKLEEKHSQITELENLVQRMEKEKRTLLERKLS 211
Query: 2091 LNNKQLSQMLKSSAPAQEEEED---PLAYYENHTSQIEIV--RQDRSMEQIVFPVPGICQ 2145
L NK L LKSSA + +D ++ + S ++ V Q +++ ++ + G+
Sbjct: 212 LENKLL--QLKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKN 269
Query: 2146 FLTEETK 2152
L E+ K
Sbjct: 270 NLKEQDK 276
>gi|13376818 coiled-coil domain containing 68 [Homo sapiens]
Length = 335
Score = 33.9 bits (76), Expect = 2.2
Identities = 32/127 (25%), Positives = 61/127 (48%), Gaps = 8/127 (6%)
Query: 2031 KAYLQEEERENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLS 2090
K LQ + E + + V N+ +A +L + Q+ L V+R+++E+ + LS
Sbjct: 153 KQLLQVNKLEKEQKLKQHV-ENLNQVAEKLEEKHSQITELENLVQRMEKEKRTLLERKLS 211
Query: 2091 LNNKQLSQMLKSSAPAQEEEED---PLAYYENHTSQIEIV--RQDRSMEQIVFPVPGICQ 2145
L NK L LKSSA + +D ++ + S ++ V Q +++ ++ + G+
Sbjct: 212 LENKLL--QLKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKN 269
Query: 2146 FLTEETK 2152
L E+ K
Sbjct: 270 NLKEQDK 276
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 33.9 bits (76), Expect = 2.2
Identities = 20/72 (27%), Positives = 38/72 (52%)
Query: 2025 LVDVIKKAYLQEEERENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEG 2084
L + +++ LQ EE EN+ S R+ N + L L R + LQ + +K++ EEE +
Sbjct: 185 LREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQE 244
Query: 2085 ISSMLSLNNKQL 2096
+ + + + Q+
Sbjct: 245 LQAQIQEQHVQI 256
>gi|4758648 kinesin family member 5B [Homo sapiens]
Length = 963
Score = 33.9 bits (76), Expect = 2.2
Identities = 16/45 (35%), Positives = 25/45 (55%)
Query: 2612 SNEGEGEQNEIRILQDKLNSTMKLVSHLTAQLNELKEQMTEQRKR 2656
S E E + E +L D+LN ++ + A+L +LKE Q+KR
Sbjct: 506 SQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKR 550
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 33.9 bits (76), Expect = 2.2
Identities = 38/147 (25%), Positives = 66/147 (44%), Gaps = 18/147 (12%)
Query: 1987 DLVLQLK---DNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERENSE 2043
DLV QL+ + + L L S + E + ++ SL + K+ + EE R+N E
Sbjct: 936 DLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEES----LNKEKQVTEEVRKNIE 991
Query: 2044 VSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLKSS 2103
V +E QL K+L + K + +Q+++ I SM +QLS++ K+
Sbjct: 992 VRLKESAE----FQTQLE---KKLMEVEKEKQELQDDKRRAIESM----EQQLSELKKTL 1040
Query: 2104 APAQEEEEDPLAYYENHTSQIEIVRQD 2130
+ Q E ++ L S + R+D
Sbjct: 1041 SSVQNEVQEALQRASTALSNEQQARRD 1067
Score = 33.1 bits (74), Expect = 3.8
Identities = 38/182 (20%), Positives = 79/182 (43%), Gaps = 17/182 (9%)
Query: 1099 ISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSGKGEEVEA-GAAK------------ 1145
+ A DV + K + L++ + ++ W++ + K +E+ A G K
Sbjct: 169 LQASDV-SVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLE 227
Query: 1146 DKKERPTDEEGFLHPPGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNMDAHKV 1205
+KKE + E ++ G K+S N + K + + L K+ EQ +++ ++AH
Sbjct: 228 NKKEEVSRLEEQMN--GLKTS-NEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK 284
Query: 1206 MLDLLQIPYDKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTPGLLEAETMQ 1265
+ +L + D +AK E+ R + + N+A+ L + + +E E ++
Sbjct: 285 LSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLE 344
Query: 1266 HI 1267
I
Sbjct: 345 KI 346
>gi|24308111 FGFR1 oncogene partner 2 [Homo sapiens]
Length = 253
Score = 33.9 bits (76), Expect = 2.2
Identities = 33/134 (24%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 2002 ALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERENSEVSPREVGHNIYILALQLS 2061
AL+E D ++A LI V QEE +E +EV+ + + Q +
Sbjct: 14 ALVERLRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQEN 73
Query: 2062 RHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQEEEEDP---LAYYE 2118
R ++LQ K ++ EE + ++S +Q+ ++L +S +++DP + E
Sbjct: 74 RQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMAS-----KKDDPGIIMKLKE 128
Query: 2119 NHTSQIEIVRQDRS 2132
H S+I++V +++S
Sbjct: 129 QH-SKIDMVHRNKS 141
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 33.5 bits (75), Expect = 2.9
Identities = 33/143 (23%), Positives = 61/143 (42%), Gaps = 2/143 (1%)
Query: 1993 KDNASKLLLALMESRHDSENAERILISLRPQE-LVDVIKKAYLQEEERENSEVSPREVGH 2051
K+ S + + H SE E +L L QE L ++ +EEERE EV E
Sbjct: 2210 KEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEER 2269
Query: 2052 NIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQEEEE 2111
+ + K+ + K K ++EE + + + +S+ S +EEEE
Sbjct: 2270 KEEEEGEE-KQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEE 2328
Query: 2112 DPLAYYENHTSQIEIVRQDRSME 2134
+ + E + EI+++++ +
Sbjct: 2329 ESCSLEEEVDREKEILKKEKQFK 2351
>gi|157739936 chromosome 10 open reading frame 68 [Homo sapiens]
Length = 628
Score = 33.5 bits (75), Expect = 2.9
Identities = 38/163 (23%), Positives = 72/163 (44%), Gaps = 21/163 (12%)
Query: 1987 DLVLQLKDNASKLLLALMESR----------HDSENAERILISLRPQELVDVIKKAYLQE 2036
+LVL+ +D+ SKL + + +++ HD E+ E ++ + D + K +Q
Sbjct: 97 NLVLEHQDSVSKLEMQIEKTKKLPREKRHSTHDEESGENPMLKHQ-----DSVSKIQVQL 151
Query: 2037 EERENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQL 2096
E +E SE R + + Q S Q+Q K+I + ++ N +
Sbjct: 152 EIQETSEGEGRSIPDKNSMFVHQDSVSKLQMQEK----KKITPGRERRNTRIVVPNENVI 207
Query: 2097 S--QMLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIV 2137
S Q KS QE+++ + T +EI ++D S+E ++
Sbjct: 208 SVHQDSKSKLQMQEKKQINSGVERHKTFPLEIKKKDISLEHLL 250
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 33.1 bits (74), Expect = 3.8
Identities = 31/135 (22%), Positives = 61/135 (45%), Gaps = 10/135 (7%)
Query: 1990 LQLKDNASKLLLALMESRHDS-ENAERILISLRPQELVDVIKKAYLQEEERENSEVSPRE 2048
L+ + N K+ A + +H S E A+ + + ++ KK + E RE +E +
Sbjct: 684 LEQEVNEHKVTKARLTDKHQSIEEAKSVA-------MCEMEKKLKEEREAREKAENRVVQ 736
Query: 2049 VGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQE 2108
+ +L + L + ++L+HL +R+++E + +NK+L +L++ Q
Sbjct: 737 IEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRL--LLQNELKTQA 794
Query: 2109 EEEDPLAYYENHTSQ 2123
E D L E Q
Sbjct: 795 FEADNLKGLEKQMKQ 809
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 33.1 bits (74), Expect = 3.8
Identities = 36/133 (27%), Positives = 65/133 (48%), Gaps = 19/133 (14%)
Query: 2003 LMESRHDSENAERILISLRPQELVDVIKKAY-----LQEE-ERENSEVSPREVG-HNIYI 2055
+++ + + N E+ L +E D IK+ LQ+E +REN+ + + +
Sbjct: 342 IVDLQREKNNVEQDL-----KEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQE 396
Query: 2056 LALQLSRHNKQLQHLLKPVKRIQEEEAEGISSM---LSLNNKQLSQMLKSSAPAQEEEED 2112
L +L QL+ LK V++ EEA+ ISS+ L+ Q+S + A A+EE
Sbjct: 397 LLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREE--- 453
Query: 2113 PLAYYENHTSQIE 2125
L+ + T+++E
Sbjct: 454 -LSRLQQETAELE 465
>gi|195976805 hypoxia up-regulated 1 precursor [Homo sapiens]
Length = 999
Score = 33.1 bits (74), Expect = 3.8
Identities = 25/110 (22%), Positives = 49/110 (44%), Gaps = 12/110 (10%)
Query: 1137 EEVEAGAAKDKKERPTDEEGFLHPPGEKSSENYQIVKGILERLNKMCGVG---------- 1186
EE EA + P + +G P GEK++E K ++ ++ G
Sbjct: 624 EEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEG 683
Query: 1187 --EQMRKKQQRLLKNMDAHKVMLDLLQIPYDKGDAKMMEILRYTHQFLQK 1234
+Q +++R+++ + V+LDL +P DK + ++ T + L+K
Sbjct: 684 EKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEK 733
>gi|5453832 hypoxia up-regulated 1 precursor [Homo sapiens]
Length = 999
Score = 33.1 bits (74), Expect = 3.8
Identities = 25/110 (22%), Positives = 49/110 (44%), Gaps = 12/110 (10%)
Query: 1137 EEVEAGAAKDKKERPTDEEGFLHPPGEKSSENYQIVKGILERLNKMCGVG---------- 1186
EE EA + P + +G P GEK++E K ++ ++ G
Sbjct: 624 EEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEG 683
Query: 1187 --EQMRKKQQRLLKNMDAHKVMLDLLQIPYDKGDAKMMEILRYTHQFLQK 1234
+Q +++R+++ + V+LDL +P DK + ++ T + L+K
Sbjct: 684 EKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEK 733
>gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform 2
[Homo sapiens]
Length = 1006
Score = 33.1 bits (74), Expect = 3.8
Identities = 20/66 (30%), Positives = 31/66 (46%), Gaps = 4/66 (6%)
Query: 1109 VIKSELDRLRTM-VEKSELWVDKKGSGKGEEVEAGAAKDKKERPTDEEGFLHPPGEKSSE 1167
+IK + R R + E+ ++W +K KGE G K++R DE EK+ E
Sbjct: 923 IIKEGMIRFRVLSTEERKVWANK---AKGETASEGTEAKKRKRVVDESDETENQEEKAKE 979
Query: 1168 NYQIVK 1173
N + K
Sbjct: 980 NLNLSK 985
>gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1
[Homo sapiens]
Length = 1129
Score = 33.1 bits (74), Expect = 3.8
Identities = 20/66 (30%), Positives = 31/66 (46%), Gaps = 4/66 (6%)
Query: 1109 VIKSELDRLRTM-VEKSELWVDKKGSGKGEEVEAGAAKDKKERPTDEEGFLHPPGEKSSE 1167
+IK + R R + E+ ++W +K KGE G K++R DE EK+ E
Sbjct: 1046 IIKEGMIRFRVLSTEERKVWANK---AKGETASEGTEAKKRKRVVDESDETENQEEKAKE 1102
Query: 1168 NYQIVK 1173
N + K
Sbjct: 1103 NLNLSK 1108
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,274,876
Number of Sequences: 37866
Number of extensions: 4206351
Number of successful extensions: 13336
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 13001
Number of HSP's gapped (non-prelim): 278
length of query: 2671
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2551
effective length of database: 13,703,598
effective search space: 34957878498
effective search space used: 34957878498
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.