Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 153792227

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
         (708 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]           1426   0.0  
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]           1426   0.0  
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]           1426   0.0  
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]            782   0.0  
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]             638   0.0  
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]             638   0.0  
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo...   171   2e-42
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]            164   3e-40
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...   157   2e-38
gi|51317373 netrin-G1 ligand [Homo sapiens]                           145   2e-34
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo...   138   2e-32
gi|198041768 synleurin [Homo sapiens]                                 137   3e-32
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]         130   4e-30
gi|31542244 leucine rich repeat and fibronectin type III domain ...   129   7e-30
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]           129   7e-30
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...   129   7e-30
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ...   128   2e-29
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   127   5e-29
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   126   8e-29
gi|109150416 peroxidasin [Homo sapiens]                               115   2e-25
gi|149773484 leucine rich repeat and fibronectin type III domain...   114   3e-25
gi|4758460 glycoprotein V (platelet) [Homo sapiens]                   113   5e-25
gi|27363458 leucine rich repeat and fibronectin type III domain ...   112   2e-24
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...   111   2e-24
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...   111   2e-24
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho...   110   3e-24
gi|194440719 chondroadherin-like [Homo sapiens]                       110   4e-24
gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo s...   109   8e-24
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ...   109   1e-23
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom...   109   1e-23

>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 1426 bits (3692), Expect = 0.0
 Identities = 708/708 (100%), Positives = 708/708 (100%)

Query: 1   MKDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGL 60
           MKDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGL
Sbjct: 1   MKDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGL 60

Query: 61  LTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLS 120
           LTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLS
Sbjct: 61  LTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLS 120

Query: 121 VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN 180
           VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN
Sbjct: 121 VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN 180

Query: 181 SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES 240
           SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES
Sbjct: 181 SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES 240

Query: 241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISI 300
           ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISI
Sbjct: 241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISI 300

Query: 301 DSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNL 360
           DSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNL
Sbjct: 301 DSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNL 360

Query: 361 KEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICL 420
           KEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICL
Sbjct: 361 KEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICL 420

Query: 421 PLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGT 480
           PLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGT
Sbjct: 421 PLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGT 480

Query: 481 LDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVS 540
           LDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVS
Sbjct: 481 LDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVS 540

Query: 541 WKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQ 600
           WKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQ
Sbjct: 541 WKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQ 600

Query: 601 KNRKKCVNVTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHS 660
           KNRKKCVNVTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHS
Sbjct: 601 KNRKKCVNVTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHS 660

Query: 661 YVRNYLQKPTFALGELYPPLINLWEAGKEKSTSLKVKATVIGLPTNMS 708
           YVRNYLQKPTFALGELYPPLINLWEAGKEKSTSLKVKATVIGLPTNMS
Sbjct: 661 YVRNYLQKPTFALGELYPPLINLWEAGKEKSTSLKVKATVIGLPTNMS 708


>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 1426 bits (3692), Expect = 0.0
 Identities = 708/708 (100%), Positives = 708/708 (100%)

Query: 1   MKDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGL 60
           MKDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGL
Sbjct: 1   MKDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGL 60

Query: 61  LTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLS 120
           LTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLS
Sbjct: 61  LTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLS 120

Query: 121 VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN 180
           VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN
Sbjct: 121 VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN 180

Query: 181 SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES 240
           SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES
Sbjct: 181 SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES 240

Query: 241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISI 300
           ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISI
Sbjct: 241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISI 300

Query: 301 DSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNL 360
           DSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNL
Sbjct: 301 DSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNL 360

Query: 361 KEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICL 420
           KEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICL
Sbjct: 361 KEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICL 420

Query: 421 PLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGT 480
           PLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGT
Sbjct: 421 PLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGT 480

Query: 481 LDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVS 540
           LDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVS
Sbjct: 481 LDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVS 540

Query: 541 WKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQ 600
           WKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQ
Sbjct: 541 WKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQ 600

Query: 601 KNRKKCVNVTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHS 660
           KNRKKCVNVTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHS
Sbjct: 601 KNRKKCVNVTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHS 660

Query: 661 YVRNYLQKPTFALGELYPPLINLWEAGKEKSTSLKVKATVIGLPTNMS 708
           YVRNYLQKPTFALGELYPPLINLWEAGKEKSTSLKVKATVIGLPTNMS
Sbjct: 661 YVRNYLQKPTFALGELYPPLINLWEAGKEKSTSLKVKATVIGLPTNMS 708


>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 1426 bits (3692), Expect = 0.0
 Identities = 708/708 (100%), Positives = 708/708 (100%)

Query: 1   MKDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGL 60
           MKDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGL
Sbjct: 1   MKDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGL 60

Query: 61  LTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLS 120
           LTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLS
Sbjct: 61  LTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLS 120

Query: 121 VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN 180
           VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN
Sbjct: 121 VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN 180

Query: 181 SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES 240
           SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES
Sbjct: 181 SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES 240

Query: 241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISI 300
           ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISI
Sbjct: 241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISI 300

Query: 301 DSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNL 360
           DSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNL
Sbjct: 301 DSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNL 360

Query: 361 KEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICL 420
           KEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICL
Sbjct: 361 KEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICL 420

Query: 421 PLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGT 480
           PLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGT
Sbjct: 421 PLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGT 480

Query: 481 LDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVS 540
           LDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVS
Sbjct: 481 LDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVS 540

Query: 541 WKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQ 600
           WKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQ
Sbjct: 541 WKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQ 600

Query: 601 KNRKKCVNVTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHS 660
           KNRKKCVNVTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHS
Sbjct: 601 KNRKKCVNVTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHS 660

Query: 661 YVRNYLQKPTFALGELYPPLINLWEAGKEKSTSLKVKATVIGLPTNMS 708
           YVRNYLQKPTFALGELYPPLINLWEAGKEKSTSLKVKATVIGLPTNMS
Sbjct: 661 YVRNYLQKPTFALGELYPPLINLWEAGKEKSTSLKVKATVIGLPTNMS 708


>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
          Length = 716

 Score =  782 bits (2020), Expect = 0.0
 Identities = 379/683 (55%), Positives = 508/683 (74%), Gaps = 3/683 (0%)

Query: 10  VLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPA 69
           ++LGL +T+L ++  +  +CP+LC CEIRPWFTP+S Y EA+TVDCNDL L   P+ L +
Sbjct: 13  LVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSS 72

Query: 70  NTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129
           +TQ+LLLQ+NNIAK         NLT LD SQNN +++  + +  + QL +++LEEN++T
Sbjct: 73  DTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQIT 132

Query: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPN 189
           E+ + CL +LSNLQELYINHN +STIS  AF GL NLLRLHLNSN+L++I+S+WFD+ PN
Sbjct: 133 EMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPN 192

Query: 190 LEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLI 249
           LEILMIGENP+I I DMNFKPL NLRSLV+AG+ LT+IP NALVGL++LES+SFYDN+L+
Sbjct: 193 LEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLV 252

Query: 250 KVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLP 309
           KVP +ALQKV NLKFLDLNKNPI++I+ GDF NML LKELGINNM EL+S+D  A+DNLP
Sbjct: 253 KVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLP 312

Query: 310 DLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNP 369
           +L K+EATNNP+LSYIH  AF  +P LESLMLN+NAL+A+Y  T+ESLPNL+EISIHSNP
Sbjct: 313 ELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNP 372

Query: 370 IRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFP 429
           +RCDCVI W+N NKTNIRFMEP S+FC  PPE++G  V++V  +D  E CLP+I+ +SFP
Sbjct: 373 LRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFP 432

Query: 430 SNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPK 489
           + LNV+ G+ V   CRA AEP+PEIYW+TP G K+   TL+DK+ + SEGTL+I+ +  +
Sbjct: 433 NRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIE 492

Query: 490 EGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVSWKASSKILK 549
           + G YTC+A N+ GAD +   IKV+G+   D    L I ++  +++S+LVSWK +S ++ 
Sbjct: 493 DSGRYTCVAQNVQGADTRVATIKVNGTL-LDGTQVLKIYVKQTESHSILVSWKVNSNVMT 551

Query: 550 SSVKW-TAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVN 608
           S++KW +A +K +N H   +AR+P DV  YNLTHL PST+Y++C+ +  I+Q+ +K CVN
Sbjct: 552 SNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVN 611

Query: 609 VTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHSYVRNYLQK 668
           VTTK         ++  +T L A +G +  +I +  +    +        H  ++ Y+QK
Sbjct: 612 VTTKNAAFAVDISDQETSTALAAVMGSMFAVISLASIAVYFAKRFKRKNYHHSLKKYMQK 671

Query: 669 -PTFALGELYPPLINLWEAGKEK 690
             +  L ELYPPLINLWE   EK
Sbjct: 672 TSSIPLNELYPPLINLWEGDSEK 694


>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  638 bits (1645), Expect = 0.0
 Identities = 322/633 (50%), Positives = 426/633 (67%), Gaps = 16/633 (2%)

Query: 17  TTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLL 76
           T  V  V   V CP  C C+IRPW+TPRS Y EA+TVDCNDL L   P  LPA TQ LLL
Sbjct: 17  TAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLL 76

Query: 77  QTNNIAKIEYST-DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKC 135
           Q+N+I +++ S   +  NLT LDLSQN+ S   + +   +PQLLS++LEEN+LT L +  
Sbjct: 77  QSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHS 136

Query: 136 LSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMI 195
            + L++LQELY+NHN L  I+P AF GL NLLRLHLNSN L+ I+S+WF+ LPNLEILMI
Sbjct: 137 FAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMI 196

Query: 196 GENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVA 255
           G N +  I DMNF+PL NLRSLV+AG+NL EI D AL GL++LES+SFYDN+L +VP  A
Sbjct: 197 GGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRA 256

Query: 256 LQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIE 315
           L++V  LKFLDLNKNP+ R+  GDF+NMLHLKELG+NNM EL+SID  A+ NLP+L K++
Sbjct: 257 LEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLD 316

Query: 316 ATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCV 375
            TNNPRLS+IHP AF  LP++E+LMLN+NALSAL+  T+ESLPNL+E+ +H NPIRCDCV
Sbjct: 317 ITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCV 376

Query: 376 IRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVE 435
           IRW N   T +RF+EP S  C +PP+ Q   VR+V FR+M + CLPLI+P SFP +L V 
Sbjct: 377 IRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVA 436

Query: 436 AGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYT 495
           +G  +  HCRA AEP+PEIYW+TP+G +L P     ++ V+ EGTL++  VT +E GLYT
Sbjct: 437 SGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYT 496

Query: 496 CIATNLVGADLKSVMIKVDGSFPQ---DNNGSLNIKIRDIQANSVLVSWKASSKILKSSV 552
           C+A NLVGAD K+V + V  +  Q   D    L +++++     +L+SW      + +++
Sbjct: 497 CVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNL 556

Query: 553 KWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVNVTTK 612
            W++        A   AR+P     YN+T L  +TEY  C+ +       +  CV   TK
Sbjct: 557 TWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTK 616

Query: 613 GLHPDQKEYEKNNTTTLMACLGGLLGIIGVICL 645
                         T+    LG   G+I ++ L
Sbjct: 617 ------------EATSCHRALGDRPGLIAILAL 637


>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  638 bits (1645), Expect = 0.0
 Identities = 322/633 (50%), Positives = 426/633 (67%), Gaps = 16/633 (2%)

Query: 17  TTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLL 76
           T  V  V   V CP  C C+IRPW+TPRS Y EA+TVDCNDL L   P  LPA TQ LLL
Sbjct: 17  TAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLL 76

Query: 77  QTNNIAKIEYST-DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKC 135
           Q+N+I +++ S   +  NLT LDLSQN+ S   + +   +PQLLS++LEEN+LT L +  
Sbjct: 77  QSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHS 136

Query: 136 LSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMI 195
            + L++LQELY+NHN L  I+P AF GL NLLRLHLNSN L+ I+S+WF+ LPNLEILMI
Sbjct: 137 FAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMI 196

Query: 196 GENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVA 255
           G N +  I DMNF+PL NLRSLV+AG+NL EI D AL GL++LES+SFYDN+L +VP  A
Sbjct: 197 GGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRA 256

Query: 256 LQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIE 315
           L++V  LKFLDLNKNP+ R+  GDF+NMLHLKELG+NNM EL+SID  A+ NLP+L K++
Sbjct: 257 LEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLD 316

Query: 316 ATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCV 375
            TNNPRLS+IHP AF  LP++E+LMLN+NALSAL+  T+ESLPNL+E+ +H NPIRCDCV
Sbjct: 317 ITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCV 376

Query: 376 IRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVE 435
           IRW N   T +RF+EP S  C +PP+ Q   VR+V FR+M + CLPLI+P SFP +L V 
Sbjct: 377 IRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVA 436

Query: 436 AGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYT 495
           +G  +  HCRA AEP+PEIYW+TP+G +L P     ++ V+ EGTL++  VT +E GLYT
Sbjct: 437 SGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYT 496

Query: 496 CIATNLVGADLKSVMIKVDGSFPQ---DNNGSLNIKIRDIQANSVLVSWKASSKILKSSV 552
           C+A NLVGAD K+V + V  +  Q   D    L +++++     +L+SW      + +++
Sbjct: 497 CVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNL 556

Query: 553 KWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVNVTTK 612
            W++        A   AR+P     YN+T L  +TEY  C+ +       +  CV   TK
Sbjct: 557 TWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTK 616

Query: 613 GLHPDQKEYEKNNTTTLMACLGGLLGIIGVICL 645
                         T+    LG   G+I ++ L
Sbjct: 617 ------------EATSCHRALGDRPGLIAILAL 637


>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
           sapiens]
          Length = 606

 Score =  171 bits (434), Expect = 2e-42
 Identities = 133/529 (25%), Positives = 224/529 (42%), Gaps = 64/529 (12%)

Query: 12  LGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANT 71
           LGLA+  +       + CP  C C             +  +V C+   L+  P  +P  T
Sbjct: 13  LGLAVVLIFMG--STIGCPARCECSA-----------QNKSVSCHRRRLIAIPEGIPIET 59

Query: 72  QILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTEL 131
           +IL                       DLS+N L SV        P L  + L +N +  +
Sbjct: 60  KIL-----------------------DLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANV 96

Query: 132 PEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLE 191
                + L NL+ L +  N L  +  G F GL NL +L ++ N++ ++    F  L NL+
Sbjct: 97  EPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLK 156

Query: 192 ILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKV 251
            L +G+N ++ I    F  L++L  L +   NLT +P  AL  L +L S+      +  +
Sbjct: 157 SLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNM 216

Query: 252 PHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDL 311
           P  A +++ +LK L+++  P+  +   +    L+L  L + N   L ++  LA  +L  L
Sbjct: 217 PVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTN-TNLSTVPFLAFKHLVYL 275

Query: 312 RKIEATNNP-----------------------RLSYIHPNAFFRLPKLESLMLNSNALSA 348
             +  + NP                       +L  I P++F  L  L  L ++ N L  
Sbjct: 276 THLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLET 335

Query: 349 LYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVR 408
           L      S   L+ +SI++NP+ CDC + W+   +  ++F     + C  P   + ++ +
Sbjct: 336 LEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQFGGQQPM-CAGPDTIRERSFK 394

Query: 409 QVHFR--DMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLP 466
             H         C      E    +L V+ G  V   C A  +PQP I W+TP  ++ + 
Sbjct: 395 DFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPR-RRFIT 453

Query: 467 NTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDG 515
                +  V  +GTL+I     ++ G+Y CIA+N  G D  +  + V G
Sbjct: 454 TKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKG 502


>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
          Length = 620

 Score =  164 bits (414), Expect = 3e-40
 Identities = 126/436 (28%), Positives = 191/436 (43%), Gaps = 60/436 (13%)

Query: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182
           L +N++  L +   +   +L+EL +N N++S + PGAF  L NL  L L SNRL++I   
Sbjct: 78  LGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLG 137

Query: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESIS 242
            F  L NL  L I EN I+ + D  F+ L NL+SL +   +L  I   A  GL +LE ++
Sbjct: 138 VFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLT 197

Query: 243 FYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMP------- 295
                L  +P  AL  +  L  L L    IN IR   F  +  LK L I++ P       
Sbjct: 198 LEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTP 257

Query: 296 ----------------ELISIDSLAVDNLPDLRKIEATNNP------------------- 320
                            L ++  LAV +L  LR +  + NP                   
Sbjct: 258 NCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQ 317

Query: 321 ----RLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVI 376
               +L+ + P AF  L  L  L ++ N L+ L      S+ NL+ + + SNP+ CDC +
Sbjct: 318 LVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRL 377

Query: 377 RWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLP-------LIAPESFP 429
            W+   +  + F       C  P   QG+      F+D  ++ LP           +   
Sbjct: 378 LWVFRRRWRLNFNRQQPT-CATPEFVQGK-----EFKDFPDVLLPNYFTCRRARIRDRKA 431

Query: 430 SNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPK 489
             + V+ G  V F CRA  +P P I W++P  + L+      +  V  +GTL++     +
Sbjct: 432 QQVFVDEGHTVQFVCRADGDPPPAILWLSPR-KHLVSAKSNGRLTVFPDGTLEVRYAQVQ 490

Query: 490 EGGLYTCIATNLVGAD 505
           + G Y CIA N  G D
Sbjct: 491 DNGTYLCIAANAGGND 506



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 34/111 (30%), Positives = 62/111 (55%)

Query: 90  FPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINH 149
           + +NLT L ++  NL++V  + V+ +  L  + L  N ++ +    L EL  LQE+ +  
Sbjct: 261 YGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVG 320

Query: 150 NLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPI 200
             L+ + P AF GL+ L  L+++ N+L  +    F ++ NLE L++  NP+
Sbjct: 321 GQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371



 Score = 37.0 bits (84), Expect = 0.063
 Identities = 18/66 (27%), Positives = 34/66 (51%)

Query: 306 DNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISI 365
           + +P   ++      R+  ++ + F   P LE L LN N +SA+  G   +L NL+ + +
Sbjct: 67  EGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGL 126

Query: 366 HSNPIR 371
            SN ++
Sbjct: 127 RSNRLK 132


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score =  157 bits (398), Expect = 2e-38
 Identities = 134/546 (24%), Positives = 213/546 (39%), Gaps = 114/546 (20%)

Query: 11  LLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPAN 70
           +L L +  L  A      CP  C C +           +   V C    L   P  +PA 
Sbjct: 7   VLSLPLLLLPAAPPPAGGCPARCECTV-----------QTRAVACTRRRLTAVPDGIPAE 55

Query: 71  TQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTE 130
           T++L                       +LS+N +  +   ++  +P L  + L EN +  
Sbjct: 56  TRLL-----------------------ELSRNRIRCLNPGDLAALPALEELDLSENAIAH 92

Query: 131 LPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNL 190
           +     + L  L+ L +  N L  I PG F  L NL  L L+ N+L ++    F  L +L
Sbjct: 93  VEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSL 152

Query: 191 EILMIGENPIIRIKDMNFKPLINLRSLVIAGINLT------------------------- 225
             L +G+N ++ +    F  L+ L  L +   NLT                         
Sbjct: 153 RRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIAS 212

Query: 226 ------------------------EIPDNALVGLENLESISFYDNRLIKVPHVALQKVVN 261
                                   E+   +L GL NL S+S     +  VP  AL+   +
Sbjct: 213 LEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGL-NLTSLSVTHTNITAVPAAALRHQAH 271

Query: 262 LKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPR 321
           L  L+L+ NPI+ + RG F +++ L+EL +                              
Sbjct: 272 LTCLNLSHNPISTVPRGSFRDLVRLRELHL--------------------------AGAL 305

Query: 322 LSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNM 381
           L+ + P AF  L ++  L L++N LS L   T  S+  L+ + +  NP+ CDC + W+  
Sbjct: 306 LAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQ 365

Query: 382 NKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMME--ICLPLIAPESFPSNLNVEAGSY 439
            +  + F +     C  P E +G  +R +    + E  +C      E     +   AG  
Sbjct: 366 RRKTLNF-DGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGED 424

Query: 440 VSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIAT 499
           V F CRA  EP P + W+TP   + +  T   +  V   GTL+I    P++ G YTC+A+
Sbjct: 425 VRFLCRAEGEPAPTVAWVTPQ-HRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTCVAS 483

Query: 500 NLVGAD 505
           N  G D
Sbjct: 484 NAGGND 489


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score =  145 bits (365), Expect = 2e-34
 Identities = 136/509 (26%), Positives = 214/509 (42%), Gaps = 99/509 (19%)

Query: 10  VLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPA 69
           VLL L +  +   V  +  CP +C+C             + S V C    L   P  +  
Sbjct: 29  VLLALQLLVVAGLVRAQT-CPSVCSCS-----------NQFSKVICVRKNLREVPDGIST 76

Query: 70  NTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129
           NT++L L  N I  I+ ++                        K +  L  + L  N + 
Sbjct: 77  NTRLLNLHENQIQIIKVNS-----------------------FKHLRHLEILQLSRNHIR 113

Query: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPN 189
            +     + L+NL  L +  N L+TI  GAF+ L  L  L L +N ++ I S  F+ +P+
Sbjct: 114 TIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPS 173

Query: 190 LEILMIGE-NPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRL 248
           L  L +GE   +  I +  F+ L NLR L +A  NL EIP+                   
Sbjct: 174 LRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPN------------------- 214

Query: 249 IKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNL 308
                  L  ++ L  LDL+ N ++ IR G F  ++HL++L +        I S      
Sbjct: 215 -------LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWM--------IQS------ 253

Query: 309 PDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSN 368
                       ++  I  NAF  L  L  + L  N L+ L H     L +L+ I +H N
Sbjct: 254 ------------QIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301

Query: 369 PIRCDCVIRWMNMNKTNIRFMEPDSLFCV----DPPEFQGQNVRQVHFRDMMEICLPLIA 424
           P  C+C I W++     I+ M P +  C      PP  +G+ + ++  ++      P+I 
Sbjct: 302 PWNCNCDILWLSW---WIKDMAPSNTACCARCNTPPNLKGRYIGELD-QNYFTCYAPVIV 357

Query: 425 PESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDIN 484
               P++LNV  G      CRA+      + WITP+G  +       +  V S+GTL+  
Sbjct: 358 EP--PADLNVTEGMAAELKCRASTS-LTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFT 414

Query: 485 GVTPKEGGLYTCIATNLVGADLKSVMIKV 513
            VT ++ G+YTC+ +N VG    S  + V
Sbjct: 415 NVTVQDTGMYTCMVSNSVGNTTASATLNV 443


>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
           sapiens]
          Length = 593

 Score =  138 bits (348), Expect = 2e-32
 Identities = 132/527 (25%), Positives = 219/527 (41%), Gaps = 74/527 (14%)

Query: 29  CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
           CP +C C  +P             V C    L   P  LP +T++L              
Sbjct: 31  CPAVCDCTSQP-----------QAVLCGHRQLEAVPGGLPLDTELL-------------- 65

Query: 89  DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYIN 148
                    DLS N L  +    + ++  L  + L  N+L+ L       L +L  L + 
Sbjct: 66  ---------DLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQ 116

Query: 149 HNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNF 208
            N L  + PG F GL  L  L L  N++ +     F  L +L+ L +G+N ++ +    F
Sbjct: 117 GNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAF 176

Query: 209 KPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268
             L  L +L +   NL+ +P  AL  L  L ++   +  + ++P  AL+ +  LK L+++
Sbjct: 177 AGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIH 236

Query: 269 KNP-INRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNP------- 320
             P +  +  G     L+L  L I     L S+   A+ +L  LR ++ + NP       
Sbjct: 237 LWPSLEALDPGSLVG-LNLSSLAITRC-NLSSVPFQALYHLSFLRVLDLSQNPISAIPAR 294

Query: 321 ----------------RLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEIS 364
                            L+ I  +AF  L     L +  NAL  L      S   L  + 
Sbjct: 295 RLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLR 354

Query: 365 IHSNPIRCDCVIRWMNMNKTNIRF-MEPDSLFCVDPPEFQGQNVRQVHFRDMME----IC 419
           +  NP+ CDC + W+   + ++ F M P +  C  P   QG+++++  F D++      C
Sbjct: 355 LSGNPLTCDCRLLWLLRLRRHLDFGMSPPA--CAGPHHVQGKSLKE--FSDILPPGHFTC 410

Query: 420 LPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEG 479
            P +  +S P  +  E G +  F C    +P P + W+ P G  L       +  V  +G
Sbjct: 411 KPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL---GRAGRVRVLEDG 467

Query: 480 TLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLN 526
           TL+I  V  ++ G Y C+ +N+ G D     ++V    P   NG+L+
Sbjct: 468 TLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPP--NGTLS 512


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score =  137 bits (346), Expect = 3e-32
 Identities = 103/365 (28%), Positives = 183/365 (50%), Gaps = 14/365 (3%)

Query: 53  VDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYSTDFPV-NLTGLDLSQNNLSSVTNIN 111
           ++C +LGL + P   P +T  L L  NNI+ I  S    + +L  L L  +N+  V    
Sbjct: 44  INCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKA 103

Query: 112 VKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHL 171
             ++  L  ++L  N +  L       L NL+ LY+ +N +S +  G F  L ++  L+L
Sbjct: 104 FVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNL 163

Query: 172 NSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNA 231
             NRL ++ S  F  +  L IL +  N I+RI +  F+ L NL  L +   NLT++P NA
Sbjct: 164 QRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNA 223

Query: 232 LVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGI 291
              L++L  +S   N +  +   A + + NL++L L  + I  + R  FS + +LK L I
Sbjct: 224 FEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHL-I 282

Query: 292 NNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRL-PKLESLMLNSNALSALY 350
            +  +L +++S     L +L  ++   N R+  I  + F  +   L+ L L+ N L+AL+
Sbjct: 283 LSHNDLENLNSDTFSLLKNLIYLKLDRN-RIISIDNDTFENMGASLKILNLSFNNLTALH 341

Query: 351 HGTIESLPNLKEISIHSNPIRCDCVI----RWMNMNKTNIRFMEPDSLFCVDPPEFQGQN 406
              ++ L +L  +  +SNP  C+C +     W+  +   +      +++C +PP  +G+ 
Sbjct: 342 PRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITL------NIYCQNPPSMRGRA 395

Query: 407 VRQVH 411
           +R ++
Sbjct: 396 LRYIN 400


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score =  130 bits (327), Expect = 4e-30
 Identities = 107/404 (26%), Positives = 177/404 (43%), Gaps = 34/404 (8%)

Query: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182
           L+EN +  +       L +L+ L ++ NL+  I  GAF GL +L  L L  NRL  + ++
Sbjct: 93  LQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQ 152

Query: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTE-IPDNALVGLENLESI 241
            F+ L  L  L +  NPI  I    F  + +LR L +  +   E I + A  GL NL  +
Sbjct: 153 AFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYL 212

Query: 242 SFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISID 301
           +     L  +P+  L  +V L+ L+L+ N ++ IR G F  +  L++L +          
Sbjct: 213 NLGMCNLKDIPN--LTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWL---------- 260

Query: 302 SLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLK 361
                            + +++ I  NAF  L  LE L L+ N L +L H     L  L+
Sbjct: 261 ----------------MHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLE 304

Query: 362 EISIHSNPIRCDCVIRWMN-MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICL 420
            + ++ NP  C+C + W++   K  +         C  P   +G+ + ++          
Sbjct: 305 RVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAP 364

Query: 421 PLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGT 480
            ++ P   P++LNV  G      CR T      + W+TP+G  +   +   +  V  +GT
Sbjct: 365 VIVEP---PTDLNVTEGMAAELKCR-TGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGT 420

Query: 481 LDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGS 524
           L+   VT ++ G YTC+ TN  G    S  + V    P    G+
Sbjct: 421 LNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGT 464


>gi|31542244 leucine rich repeat and fibronectin type III domain
           containing 5 [Homo sapiens]
          Length = 719

 Score =  129 bits (325), Expect = 7e-30
 Identities = 112/429 (26%), Positives = 185/429 (43%), Gaps = 75/429 (17%)

Query: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182
           L +N +T +  K  + +++L +L ++ N +S I+P AF  L NL  LHLNSNRL  I + 
Sbjct: 58  LADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITND 117

Query: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESIS 242
            F  L NL  L++  N                         LT I   A   +  LE + 
Sbjct: 118 MFSGLSNLHHLILNNN------------------------QLTLISSTAFDDVFALEELD 153

Query: 243 FYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDS 302
              N L  +P  A++K+V+L  L L+ N I+ I +G FS                     
Sbjct: 154 LSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFS--------------------- 192

Query: 303 LAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKE 362
               +L  + +++ T+N +L  + P+  F+  +   ++  S  +S          P+   
Sbjct: 193 ----HLHKMTRLDVTSN-KLQKLPPDPLFQRAQ---VLATSGIIS----------PSTFA 234

Query: 363 ISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPL 422
           +S   NP+ C+C + W+          E D   C  PP   G+    +   +   +C P 
Sbjct: 235 LSFGGNPLHCNCELLWLRRLS-----REDDLETCASPPLLTGRYFWSIPEEEF--LCEPP 287

Query: 423 IAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLD 482
           +        + V  G   +  C+A  +P+P I+WI+P G KL+ N    +  V+  GTLD
Sbjct: 288 LITR-HTHEMRVLEGQRATLRCKARGDPEPAIHWISPEG-KLISN--ATRSLVYDNGTLD 343

Query: 483 INGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVSWK 542
           I   T K+ G +TCIA+N  G   + V + +    P   N + +I   D  ++ +  S K
Sbjct: 344 ILITTVKDTGAFTCIASNPAGEATQIVDLHII-KLPHLLNSTNHIHEPDPGSSDISTSTK 402

Query: 543 ASSKILKSS 551
           + S    S+
Sbjct: 403 SGSNTSSSN 411



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 63/224 (28%), Positives = 100/224 (44%), Gaps = 20/224 (8%)

Query: 11  LLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPAN 70
           L+G+A+   +        CP+ C C+I    +P    +      C   GLL  P  +   
Sbjct: 10  LIGIAVKAQI--------CPKRCVCQI---LSPNLATL------CAKKGLLFVPPNIDRR 52

Query: 71  TQILLLQTNNIAKIEYSTDFP--VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKL 128
           T  L L  N +  I+   DF    +L  L LS+N +S +T      +  L +++L  N+L
Sbjct: 53  TVELRLADNFVTNIKRK-DFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRL 111

Query: 129 TELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALP 188
           T++     S LSNL  L +N+N L+ IS  AF  +  L  L L+ N L+ I     + + 
Sbjct: 112 TKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMV 171

Query: 189 NLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNAL 232
           +L  L +  N I  I    F  L  +  L +    L ++P + L
Sbjct: 172 SLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPL 215


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score =  129 bits (325), Expect = 7e-30
 Identities = 117/442 (26%), Positives = 191/442 (43%), Gaps = 40/442 (9%)

Query: 165 NLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINL 224
           N   L+L  N +QMI +  F  L +LE+L +G N I +I+   F  L +L +L +    L
Sbjct: 76  NTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWL 135

Query: 225 TEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNK-NPINRIRRGDFSNM 283
           T IP  A   L  L  +   +N +  +P  A  +V +L  LDL +   +  I  G F  +
Sbjct: 136 TVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGL 195

Query: 284 LHLKELGIN--------NMPELISIDSLAV--DNLPDLR----------KIEATNNPRLS 323
            +LK L +         N+  L+ ++ L +  ++ P++R          K     N ++S
Sbjct: 196 FNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVS 255

Query: 324 YIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNK 383
            I  NAF  L  L  L L  N LS+L H     L  L E+ +H NP  CDC I W+    
Sbjct: 256 LIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWL---A 312

Query: 384 TNIRFMEPDSLFCVD----PPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSY 439
             +R   P +  C      P   +G+ + +V  +   +   P I     P +LN+  G  
Sbjct: 313 WWLREYIPTNSTCCGRCHAPMHMRGRYLVEVD-QASFQCSAPFIM--DAPRDLNISEGRM 369

Query: 440 VSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIAT 499
               CR    P   + W+ P+G  L   +   +  V ++GTL+ + V   + G+YTC+ T
Sbjct: 370 AELKCR--TPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVT 427

Query: 500 NLVGADLKSVMIKVDGSFPQDNNGS----LNIKIRDIQANSVLVSWKASSKILKSSVKWT 555
           N+ G    S  + V  +    +N S    + ++  +I        +K    +  +S  + 
Sbjct: 428 NVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYK---PVPTTSTGYQ 484

Query: 556 AFVKTENSHAAQSARIPSDVKV 577
               T  +   Q+ R+P  V V
Sbjct: 485 PAYTTSTTVLIQTTRVPKQVAV 506



 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 76/271 (28%), Positives = 136/271 (50%), Gaps = 17/271 (6%)

Query: 28  DCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYS 87
           +CP +C+C             + S V C   GL   P  +P+NT+ L L  NNI  I+  
Sbjct: 45  NCPSVCSCS-----------NQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQAD 93

Query: 88  TDFPV-NLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELY 146
           T   + +L  L L +N++  +       +  L ++ L +N LT +P      LS L+EL+
Sbjct: 94  TFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELW 153

Query: 147 INHNLLSTISPGAFIGLHNLLRLHLNS-NRLQMINSKWFDALPNLEILMIGENPIIRIKD 205
           + +N + +I   AF  + +L+RL L    +L+ I+   F+ L NL+ L +G   +  IKD
Sbjct: 154 LRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLG---MCNIKD 210

Query: 206 M-NFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKF 264
           M N  PL+ L  L ++G +  EI   +  GL +L+ +   ++++  +   A   + +L  
Sbjct: 211 MPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVE 270

Query: 265 LDLNKNPINRIRRGDFSNMLHLKELGINNMP 295
           L+L  N ++ +    F+ + +L EL +++ P
Sbjct: 271 LNLAHNNLSSLPHDLFTPLRYLVELHLHHNP 301


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score =  129 bits (325), Expect = 7e-30
 Identities = 134/581 (23%), Positives = 226/581 (38%), Gaps = 105/581 (18%)

Query: 11  LLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPAN 70
           LL L +  +  A   +  C   CTC                ++DC   GL   P  LP+ 
Sbjct: 23  LLLLRLEPVTAAAGPRAPCAAACTCA-------------GDSLDCGGRGLAALPGDLPSW 69

Query: 71  TQILLLQTNNIAKIEYS--TDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKL 128
           T+ L L  N +++I+ +   D P NL  + L+ N L++V ++       ++S++L+ NK+
Sbjct: 70  TRSLNLSYNKLSEIDPAGFEDLP-NLQEVYLNNNELTAVPSLGAASS-HVVSLFLQHNKI 127

Query: 129 ------------------------TELPEKCLSELSNLQELYINHNLLSTISPGAFIGLH 164
                                   TE+   C      ++EL +  N + T+  GAF GL 
Sbjct: 128 RSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLS 187

Query: 165 ------------------------NLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPI 200
                                    L +L LN NR+++I    F  L +LE+L +  N I
Sbjct: 188 RSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNI 247

Query: 201 IRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGL------------------------E 236
            ++ D  F  L  +  L +   +L E+   +L GL                        +
Sbjct: 248 SKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQ 307

Query: 237 NLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGI--NNM 294
            L  +    N L ++   +L ++ +L  L L+ N I+ I  G F  +  L+ L +  N +
Sbjct: 308 KLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEI 367

Query: 295 PELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTI 354
              I   S A   L  L K+    N ++  +   AF  L  LE L L  NA+ ++     
Sbjct: 368 SGTIEDTSGAFSGLDSLSKLTLFGN-KIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAF 426

Query: 355 ESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRD 414
             + NLKE+ I S+   CDC ++W+             +  C  P   +GQ++  V    
Sbjct: 427 VKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPES 486

Query: 415 MMEICLPLIAPE--SFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDK 472
              +C   + P+  + P       G  + F C A +     + +      ++L N   + 
Sbjct: 487 F--VCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMEN 544

Query: 473 F-YVHSEG--------TLDINGVTPKEGGLYTCIATNLVGA 504
           F +VH++          L +  VT    G Y C+ TN  G+
Sbjct: 545 FVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGS 585



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 5/73 (6%)

Query: 434 VEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEG-TLDINGVTPKEGG 492
           V  G  V+  C+AT  P P I W    G +  P +LT++ ++  +   L +  V  ++ G
Sbjct: 704 VSVGETVALQCKATGNPPPRITWF--KGDR--PLSLTERHHLTPDNQLLVVQNVVAEDAG 759

Query: 493 LYTCIATNLVGAD 505
            YTC  +N +G +
Sbjct: 760 RYTCEMSNTLGTE 772



 Score = 33.9 bits (76), Expect = 0.53
 Identities = 17/76 (22%), Positives = 28/76 (36%)

Query: 429 PSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTP 488
           P ++ +   +     C AT  P P+I W    G             +  +    I  V  
Sbjct: 605 PHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKI 664

Query: 489 KEGGLYTCIATNLVGA 504
            + G+Y+C A N  G+
Sbjct: 665 DDAGVYSCTAQNSAGS 680


>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
           [Homo sapiens]
          Length = 1065

 Score =  128 bits (322), Expect = 2e-29
 Identities = 117/478 (24%), Positives = 206/478 (43%), Gaps = 43/478 (8%)

Query: 41  FTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST--DFPVNLTGLD 98
           F P    ++ S+   +++   +FP       + L L  N I  +E     +   +L  + 
Sbjct: 142 FYPALESLDLSSNIISEIKTSSFPRM---QLKYLNLSNNRITTLEAGCFDNLSSSLLVVK 198

Query: 99  LSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPG 158
           L++N +S +    + K+P L  + L+ N++  +       L +L+ L +  N +S +  G
Sbjct: 199 LNRNRMSMIPP-KIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDG 257

Query: 159 AFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLV 218
           AF GL+N+  L L  N L  +N  W   L  L+ L + +N I RI    ++    L  L 
Sbjct: 258 AFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELD 317

Query: 219 IAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRG 278
           ++   LT + ++A VGL  LE ++  DNR+  +     + + NL+ LDL  N I+     
Sbjct: 318 LSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEIS----- 372

Query: 279 DFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLES 338
                              I   S A   L  L K+    N ++  I   AF  L  LE 
Sbjct: 373 -----------------WAIEDASEAFAGLTSLTKLILQGN-QIKSITKKAFIGLESLEH 414

Query: 339 LMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVD 398
           L LN+NA+ ++      S  +LKE+ ++++ + CDC ++W+     +  F    ++ C  
Sbjct: 415 LDLNNNAIMSIQENAF-SQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAH 473

Query: 399 PPEFQGQNVRQVHFRDMMEICLPLIAPE--SFPSNLNVEAGSYVSFHCRATAEPQPEIYW 456
           P    GQ++  V  +D   +C   + P+  + P  +    G  V+  C A +     +  
Sbjct: 474 PEWLAGQSILNVDLKDF--VCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMST 531

Query: 457 ITPSGQKLLPNTLTDKF--YVHSEG-------TLDINGVTPKEGGLYTCIATNLVGAD 505
           +     ++L +  T+ F  Y    G        L +  V   + G Y CI TN  G++
Sbjct: 532 VWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSN 589



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 105/451 (23%), Positives = 189/451 (41%), Gaps = 33/451 (7%)

Query: 74  LLLQTNNIAKIEYSTDFPVN-LTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELP 132
           L +Q N I+K++    F +N +  L+L  NNL+ V    +  +  L  +Y+ +N +  + 
Sbjct: 244 LKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERIS 303

Query: 133 EKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEI 192
                    L EL +++N L+ +   AF+GL  L RL+L  NR+  I    F  L NL+ 
Sbjct: 304 PDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQT 363

Query: 193 LMIGENPII-RIKDMN--FKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLI 249
           L +  N I   I+D +  F  L +L  L++ G  +  I   A +GLE+LE +   +N ++
Sbjct: 364 LDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIM 423

Query: 250 KVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLP 309
            +   A  +  +LK L LN + +      D      L+ L  NN    +++     + L 
Sbjct: 424 SIQENAFSQT-HLKELILNTSSL----LCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLA 478

Query: 310 -------DLRKIEATN--NPRLSYIHPNAFFRLPKLE------SLMLNSNALSALYHGTI 354
                  DL+     +   P++   HP     L  +       ++  + + +S ++    
Sbjct: 479 GQSILNVDLKDFVCDDFLKPQIR-THPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDS 537

Query: 355 ESLPNLKEISIHSNPIRCDCVIRWMN-MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFR 413
           E L ++   +      +    + + + ++  N+ F +     C+    F G N  Q    
Sbjct: 538 EILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHF-GSNYSQKAKL 596

Query: 414 DMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKF 473
            + E+   L      P +L +  G+     C A   P P+I W    G    P     + 
Sbjct: 597 TVNEMPSFL----KTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTD-FPAARERRM 651

Query: 474 YVHSE-GTLDINGVTPKEGGLYTCIATNLVG 503
           +V  E     I  V  ++ G+Y+C+A N  G
Sbjct: 652 HVMPEDDVFFIANVKIEDMGIYSCMAQNTAG 682



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 44/147 (29%), Positives = 71/147 (48%), Gaps = 4/147 (2%)

Query: 224 LTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNM 283
           LTEIP        N+  +S   N + ++   ALQ    L+ LDL+ N I+ I+   F  M
Sbjct: 109 LTEIPYFG-EPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM 167

Query: 284 LHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNS 343
             LK L ++N   + ++++   DNL     +   N  R+S I P   F+LP L+ L L  
Sbjct: 168 -QLKYLNLSN-NRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPK-IFKLPHLQFLELKR 224

Query: 344 NALSALYHGTIESLPNLKEISIHSNPI 370
           N +  +   T + L +L+ + +  N I
Sbjct: 225 NRIKIVEGLTFQGLDSLRSLKMQRNGI 251



 Score = 34.3 bits (77), Expect = 0.41
 Identities = 24/92 (26%), Positives = 39/92 (42%), Gaps = 5/92 (5%)

Query: 434 VEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDK-FYVHSEGTLDINGVTPKEGG 492
           V  G      C A   P P + W    G    P  +T++ F+  +   L I     ++ G
Sbjct: 707 VTRGETAVLQCIAGGSPAPRLNWTKDDG----PLLVTERHFFAAANQLLIIVDAGLEDAG 762

Query: 493 LYTCIATNLVGADLKSVMIKVDGSFPQDNNGS 524
            YTCI +N +G +   + + V  S   D++ S
Sbjct: 763 KYTCIMSNTLGTERGHIYLNVISSPNCDSSQS 794


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  127 bits (318), Expect = 5e-29
 Identities = 109/374 (29%), Positives = 173/374 (46%), Gaps = 22/374 (5%)

Query: 2   KDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLL 61
           K MPL+ H LL L       A      CP  CTC              AS V+C    ++
Sbjct: 5   KAMPLK-HYLLLLVGCQAWGAGLAYHGCPSECTCS------------RASQVECTGARIV 51

Query: 62  TFPARLPANTQILLLQTNNIAKIEYSTDFPVN-LTGLDLSQNNLSSVTNINVKKMPQLLS 120
             P  LP N   L +   +I ++  S    ++ L  L + +N LS +T    + +  L  
Sbjct: 52  AVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRY 111

Query: 121 VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN 180
           + L  NKL  LP      L +L+ L ++ N L  I P  F    NL  L L+ N L+ I 
Sbjct: 112 LSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIP 171

Query: 181 SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES 240
              FD L  L  L +G+N +  I    F+ L NL+ L +    LT+IP     GL NL+ 
Sbjct: 172 DGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQE 231

Query: 241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGI--NNMPELI 298
           ++   N++  +         NL+ L L+ N I+++    F  +  L  L +  N++ EL 
Sbjct: 232 LALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKEL- 290

Query: 299 SIDSLAV-DNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESL 357
              SL +   +P+LR++   +N  +S +  N F  L +L+ L+L+ N +S +  G    L
Sbjct: 291 ---SLGIFGPMPNLRELWLYDN-HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGL 346

Query: 358 PNLKEISIHSNPIR 371
             L+E+S+H+N ++
Sbjct: 347 TELRELSLHTNALQ 360



 Score =  121 bits (304), Expect = 2e-27
 Identities = 101/367 (27%), Positives = 169/367 (46%), Gaps = 37/367 (10%)

Query: 69  ANTQILLLQTNNIAKI-EYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENK 127
           +N + L L  N++  I + + D  V LT L+L +N+L+ ++    + +  L  + L EN+
Sbjct: 155 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENR 214

Query: 128 LTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDAL 187
           LT++P      L NLQEL +  N +  +SPG F   HNL RL+L++N +  +    F  L
Sbjct: 215 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 274

Query: 188 PNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNR 247
           P L  L +  N +  +    F P+ NLR L +   +++ +PDN    L  L+        
Sbjct: 275 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQ-------- 326

Query: 248 LIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDN 307
                            L L++N I+ I  G F+ +  L+EL ++    L  +D      
Sbjct: 327 ----------------VLILSRNQISFISPGAFNGLTELRELSLHT-NALQDLDGNVFRM 369

Query: 308 LPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHS 367
           L +L+ I   NN RL  +  N F  +  L ++ L +N L  L  G  + L  L E+ ++ 
Sbjct: 370 LANLQNISLQNN-RLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD 428

Query: 368 NPIRCDCVI----RWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLI 423
           NP RCD  I     W+ +N+   R        C  P   +GQ++  ++    + + +P +
Sbjct: 429 NPWRCDSDILPLRNWLLLNQP--RLGTDTVPVCFSPANVRGQSLIIIN----VNVAVPSV 482

Query: 424 APESFPS 430
                PS
Sbjct: 483 HVPEVPS 489



 Score =  121 bits (303), Expect = 3e-27
 Identities = 86/287 (29%), Positives = 145/287 (50%), Gaps = 4/287 (1%)

Query: 119 LSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQM 178
           +S+ +    +TEL E     +S L  L I  N LS I+PGAF  L +L  L L +N+LQ+
Sbjct: 62  MSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQV 121

Query: 179 INSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENL 238
           +    F  L +LE L++  N +++I+  +F    NL+ L + G +L  IPD A   L  L
Sbjct: 122 LPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGL 181

Query: 239 ESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGI-NNMPEL 297
             ++   N L  +     Q + NL+ L L +N +  I  G F  +++L+EL +  N   L
Sbjct: 182 TKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGL 241

Query: 298 ISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESL 357
           +S       N  +L+++  +NN  +S + P+ F +LP+L  L L  N+L  L  G    +
Sbjct: 242 LSPG--LFHNNHNLQRLYLSNN-HISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPM 298

Query: 358 PNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQG 404
           PNL+E+ ++ N I       + N+ +  +  +  + +  + P  F G
Sbjct: 299 PNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNG 345


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  126 bits (316), Expect = 8e-29
 Identities = 100/347 (28%), Positives = 163/347 (46%), Gaps = 21/347 (6%)

Query: 29  CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
           CP  CTC              AS V+C    ++  P  LP N   L +   +I ++  S 
Sbjct: 25  CPSECTCS------------RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESP 72

Query: 89  DFPVN-LTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYI 147
              ++ L  L + +N LS +T    + +  L  + L  NKL  LP      L +L+ L +
Sbjct: 73  FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLL 132

Query: 148 NHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMN 207
           + N L  I P  F    NL  L L+ N L+ I    FD L  L  L +G+N +  I    
Sbjct: 133 SSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRV 192

Query: 208 FKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDL 267
           F+ L NL+ L +    LT+IP     GL NL+ ++   N++  +         NL+ L L
Sbjct: 193 FQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYL 252

Query: 268 NKNPINRIRRGDFSNMLHLKELGI--NNMPELISIDSLAV-DNLPDLRKIEATNNPRLSY 324
           + N I+++    F  +  L  L +  N++ EL    SL +   +P+LR++   +N  +S 
Sbjct: 253 SNNHISQLPPSIFMQLPQLNRLTLFGNSLKEL----SLGIFGPMPNLRELWLYDN-HISS 307

Query: 325 IHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIR 371
           +  N F  L +L+ L+L+ N +S +  G    L  L+E+S+H+N ++
Sbjct: 308 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQ 354



 Score =  121 bits (304), Expect = 2e-27
 Identities = 101/367 (27%), Positives = 169/367 (46%), Gaps = 37/367 (10%)

Query: 69  ANTQILLLQTNNIAKI-EYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENK 127
           +N + L L  N++  I + + D  V LT L+L +N+L+ ++    + +  L  + L EN+
Sbjct: 149 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENR 208

Query: 128 LTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDAL 187
           LT++P      L NLQEL +  N +  +SPG F   HNL RL+L++N +  +    F  L
Sbjct: 209 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 268

Query: 188 PNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNR 247
           P L  L +  N +  +    F P+ NLR L +   +++ +PDN    L  L+        
Sbjct: 269 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQ-------- 320

Query: 248 LIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDN 307
                            L L++N I+ I  G F+ +  L+EL ++    L  +D      
Sbjct: 321 ----------------VLILSRNQISFISPGAFNGLTELRELSLHT-NALQDLDGNVFRM 363

Query: 308 LPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHS 367
           L +L+ I   NN RL  +  N F  +  L ++ L +N L  L  G  + L  L E+ ++ 
Sbjct: 364 LANLQNISLQNN-RLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD 422

Query: 368 NPIRCDCVI----RWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLI 423
           NP RCD  I     W+ +N+   R        C  P   +GQ++  ++    + + +P +
Sbjct: 423 NPWRCDSDILPLRNWLLLNQP--RLGTDTVPVCFSPANVRGQSLIIIN----VNVAVPSV 476

Query: 424 APESFPS 430
                PS
Sbjct: 477 HVPEVPS 483



 Score =  121 bits (303), Expect = 3e-27
 Identities = 86/287 (29%), Positives = 145/287 (50%), Gaps = 4/287 (1%)

Query: 119 LSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQM 178
           +S+ +    +TEL E     +S L  L I  N LS I+PGAF  L +L  L L +N+LQ+
Sbjct: 56  MSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQV 115

Query: 179 INSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENL 238
           +    F  L +LE L++  N +++I+  +F    NL+ L + G +L  IPD A   L  L
Sbjct: 116 LPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGL 175

Query: 239 ESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGI-NNMPEL 297
             ++   N L  +     Q + NL+ L L +N +  I  G F  +++L+EL +  N   L
Sbjct: 176 TKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGL 235

Query: 298 ISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESL 357
           +S       N  +L+++  +NN  +S + P+ F +LP+L  L L  N+L  L  G    +
Sbjct: 236 LSPG--LFHNNHNLQRLYLSNN-HISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPM 292

Query: 358 PNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQG 404
           PNL+E+ ++ N I       + N+ +  +  +  + +  + P  F G
Sbjct: 293 PNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNG 339


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score =  115 bits (287), Expect = 2e-25
 Identities = 81/260 (31%), Positives = 132/260 (50%), Gaps = 9/260 (3%)

Query: 246 NRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAV 305
           NR+ ++   A +++ NL  L LN N I RI  G F ++ +LK L +    E+ SID  A 
Sbjct: 72  NRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKN-EIQSIDRQAF 130

Query: 306 DNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISI 365
             L  L ++    N ++  + P++F  LPKLE L L++N ++ L  GT   L ++K + +
Sbjct: 131 KGLASLEQLYLHFN-QIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRL 189

Query: 366 HSNPIRCDCVIRWM-NMNKTNIRFMEPD-SLFCVDPPEFQGQNVRQVHFRDMMEICLPLI 423
            SN + CDC I W+ ++ KT         +  C  P   QG++V  +   + +    P I
Sbjct: 190 DSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATI-TPEELNCERPRI 248

Query: 424 APESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDI 483
             E  P + +V +G+ V F CRA   P+PEI W+  + +  L      +  +  +GTL I
Sbjct: 249 TSE--PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNE--LSMKTDSRLNLLDDGTLMI 304

Query: 484 NGVTPKEGGLYTCIATNLVG 503
                 + G+Y C+A N+ G
Sbjct: 305 QNTQETDQGIYQCMAKNVAG 324



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 85/371 (22%), Positives = 151/371 (40%), Gaps = 36/371 (9%)

Query: 145 LYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIK 204
           L +  N +  I PGAF  L NL  L LN+N+++ I S  F+ L NL+ L + +N I  I 
Sbjct: 67  LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126

Query: 205 DMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKF 264
              FK L +L  L +    +  +  ++   L  LE +  ++NR+  +       + ++K 
Sbjct: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKR 186

Query: 265 LDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSY 324
           L L+ N ++         +L L +L +    E  +  + A+   P  R+I+  +   ++ 
Sbjct: 187 LRLDSNTLH-----CDCEILWLADL-LKTYAESGNAQAAAICEYP--RRIQGRSVATITP 238

Query: 325 IHPNAFFRLPKLESLMLNSNALS---ALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNM 381
              N     P++ S   +++  S     +    E  P  + I + +N          ++M
Sbjct: 239 EELNC--ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNN--------NELSM 288

Query: 382 NKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDM------MEICLPLIAPESFPS----- 430
              +   +  D    +   +   Q + Q   +++       E+ L      + P+     
Sbjct: 289 KTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQP 348

Query: 431 -NLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPK 489
            N  V  G  V+  C AT  P P I W T   +  LP  +  +  +   G L I  V   
Sbjct: 349 QNTEVLVGESVTLECSATGHPPPRISW-TRGDRTPLP--VDPRVNITPSGGLYIQNVVQG 405

Query: 490 EGGLYTCIATN 500
           + G Y C ATN
Sbjct: 406 DSGEYACSATN 416



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 50/185 (27%), Positives = 86/185 (46%), Gaps = 15/185 (8%)

Query: 17  TTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLL 76
           T  V A      CP  C C               +TV C  L L   PA  P  T IL L
Sbjct: 24  TLAVVAQKPGAGCPSRCLCF-------------RTTVRCMHLLLEAVPAVAP-QTSILDL 69

Query: 77  QTNNIAKIEYSTDFPV-NLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKC 135
           + N I +I+      + NL  L L+ N +  + +   + +  L  +YL +N++  +  + 
Sbjct: 70  RFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQA 129

Query: 136 LSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMI 195
              L++L++LY++ N + T+ P +F  L  L RL L++NR+  +    F+ L +++ L +
Sbjct: 130 FKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRL 189

Query: 196 GENPI 200
             N +
Sbjct: 190 DSNTL 194



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 34/96 (35%), Positives = 50/96 (52%), Gaps = 6/96 (6%)

Query: 421 PLIAP--ESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSE 478
           P + P   S PS+  VE G+ V   C +  EP+P I W     Q     T + KF++  E
Sbjct: 521 PRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQV----TESGKFHISPE 576

Query: 479 GTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVD 514
           G L IN V P + G Y C+A N +G+   S+++ V+
Sbjct: 577 GFLTINDVGPADAGRYECVARNTIGSASVSMVLSVN 612



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 34/121 (28%), Positives = 63/121 (52%)

Query: 97  LDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTIS 156
           LDL  N +  +     +++  L ++ L  N++  +P     +L NL+ LY+  N + +I 
Sbjct: 67  LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126

Query: 157 PGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRS 216
             AF GL +L +L+L+ N+++ ++   F  LP LE L +  N I  +    F  L +++ 
Sbjct: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKR 186

Query: 217 L 217
           L
Sbjct: 187 L 187



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 39/133 (29%), Positives = 62/133 (46%)

Query: 116 PQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNR 175
           PQ   + L  N++ E+       L NL  L +N+N +  I  GAF  L NL  L+L  N 
Sbjct: 62  PQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNE 121

Query: 176 LQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGL 235
           +Q I+ + F  L +LE L +  N I  +   +F+ L  L  L +    +T +       L
Sbjct: 122 IQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHL 181

Query: 236 ENLESISFYDNRL 248
           E+++ +    N L
Sbjct: 182 ESMKRLRLDSNTL 194



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 28/76 (36%), Positives = 38/76 (50%), Gaps = 4/76 (5%)

Query: 429 PSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTP 488
           P +  V  G  V F C A   P P I W T  G +L   ++  +  V S GTL I+GV  
Sbjct: 439 PQDRVVIEGQTVDFQCEAKGNPPPVIAW-TKGGSQL---SVDRRHLVLSSGTLRISGVAL 494

Query: 489 KEGGLYTCIATNLVGA 504
            + G Y C A N++G+
Sbjct: 495 HDQGQYECQAVNIIGS 510


>gi|149773484 leucine rich repeat and fibronectin type III domain
           containing 1 [Homo sapiens]
          Length = 771

 Score =  114 bits (285), Expect = 3e-25
 Identities = 123/533 (23%), Positives = 203/533 (38%), Gaps = 115/533 (21%)

Query: 117 QLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRL 176
           +++ + L +N +  +  +  + +++L  L ++ N +  ++ GAF  L  L  LHL+SNRL
Sbjct: 66  RVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRL 125

Query: 177 QMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLE 236
             +       L NL  L++G N I R++   F                          L 
Sbjct: 126 AEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAF-----------------------LS 162

Query: 237 NLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPE 296
            +E +    N L  +P  A+ ++VNL  L L+ N I+ I  G F                
Sbjct: 163 TVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFV--------------- 207

Query: 297 LISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIES 356
                      L  L +++ T+N RL  + P+  F    L S             GT   
Sbjct: 208 ----------QLHKLVRLDMTSN-RLHKLPPDGLF----LRS------------QGTGPK 240

Query: 357 LPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMM 416
            P    +S   NP+ C+C + W+       R    D L     PE    ++   +F  + 
Sbjct: 241 PPTPLTVSFGGNPLHCNCELLWLR------RLTREDDLETCATPE----HLTDRYFWSIP 290

Query: 417 E---ICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKF 473
           E   +C P +          V  G  VS  CRA  +P+P ++W+ P G +LL N  + + 
Sbjct: 291 EEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDG-RLLGN--SSRT 347

Query: 474 YVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKV-------------------- 513
            V  +GTLD+   T ++ G +TCIA+N  G     V + V                    
Sbjct: 348 RVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPG 407

Query: 514 --DGSFP-----QDNNGSLNIKIRDIQANSVLVSWKASSKILKSSVKWTAFVKTENSHAA 566
             D + P      D+     +   ++ +NSVL+ W A   +    +    +  + +    
Sbjct: 408 SSDIATPGRPGANDSAAERRLVAAELTSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLV 467

Query: 567 QSARIPSDVKVYNLTHLNPSTEYKICI-----DIPTIYQKNR-KKCVNVTTKG 613
               IPS  + + +  L     Y +C+     D  T     R   CV  TT G
Sbjct: 468 Y-RMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAG 519



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 55/208 (26%), Positives = 87/208 (41%), Gaps = 15/208 (7%)

Query: 29  CPRLCTCE-IRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYS 87
           CP  C C+ + P  T          + C   GLL  P  +      L L  N IA +   
Sbjct: 34  CPGRCICQNVAPTLT----------MLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVR-R 82

Query: 88  TDFP--VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
            DF    +L  L LS+N +  V       +  L +++L+ N+L E+    L  L NL+ L
Sbjct: 83  RDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHL 142

Query: 146 YINHNLLSTISPGAFIG-LHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIK 204
            + +N +  +   AF   L  +  L L+ N L+ +  +    + NL  L +  N I  I 
Sbjct: 143 ILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIA 202

Query: 205 DMNFKPLINLRSLVIAGINLTEIPDNAL 232
           +  F  L  L  L +    L ++P + L
Sbjct: 203 EGTFVQLHKLVRLDMTSNRLHKLPPDGL 230


>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
          Length = 560

 Score =  113 bits (283), Expect = 5e-25
 Identities = 104/367 (28%), Positives = 163/367 (44%), Gaps = 35/367 (9%)

Query: 29  CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
           CP  C C  R          + S  D   +  L  P  L   T ILL           S 
Sbjct: 21  CPPACKCVFRD-------AAQCSGGDVARISALGLPTNL---THILLFGMGRGVLQSQSF 70

Query: 89  DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYIN 148
                L  L +S +++S+V       + +L ++ L  NK+T LP   L ++  L++L+++
Sbjct: 71  SGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLD 130

Query: 149 HNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKD--- 205
           HN L  I    F  L NL  L LN N+L  + +  F  L NL++L +  N +  +     
Sbjct: 131 HNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLL 190

Query: 206 ----------MNFKPLINLRSLVIAGIN-LTE----------IPDNALVGLENLESISFY 244
                     ++   L++L S ++  +  LTE          I   A   L NL S++  
Sbjct: 191 GAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLS 250

Query: 245 DNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLA 304
            N L  +P        NL  L L +NP+  +    F  M  L+EL +N   +L ++ + A
Sbjct: 251 RNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNR-TQLRTLPAAA 309

Query: 305 VDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEIS 364
             NL  LR +  T +PRLS +   AF  L +L+ L L+SN L+AL  G +  L  L+++S
Sbjct: 310 FRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVS 369

Query: 365 IHSNPIR 371
           +  N +R
Sbjct: 370 LRRNRLR 376



 Score =  105 bits (261), Expect = 2e-22
 Identities = 97/353 (27%), Positives = 154/353 (43%), Gaps = 52/353 (14%)

Query: 72  QILLLQTNNIAKIEYSTDFP-VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTE 130
           Q L++  ++I+ +   T    + L  L LS+N ++ +    + KM  L  ++L+ N L  
Sbjct: 77  QRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRG 136

Query: 131 LPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLL----------------------- 167
           + +    +L NLQEL +N N L  +    F  L NL                        
Sbjct: 137 IDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKL 196

Query: 168 -RLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTE 226
            RL L+SNRL  ++S   ++L  L  L    N I  I    F  L NL SL ++  +L  
Sbjct: 197 ERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAF 256

Query: 227 IPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHL 286
           +P    +   NL  ++ ++N L ++P V   ++  L+ L LN+  +  +    F N+  L
Sbjct: 257 LPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRL 316

Query: 287 KELGINNMPEL----------------ISIDSLAVDNLPD--------LRKIEATNNPRL 322
           + LG+   P L                +++ S  +  LPD        LR++    N RL
Sbjct: 317 RYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRN-RL 375

Query: 323 SYIHPNAFFR-LPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDC 374
             + P A FR L  LES+ L+ N L  L      +LP L E+ +  N  RCDC
Sbjct: 376 RAL-PRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDC 427


>gi|27363458 leucine rich repeat and fibronectin type III domain
           containing 4 [Homo sapiens]
          Length = 635

 Score =  112 bits (279), Expect = 2e-24
 Identities = 113/441 (25%), Positives = 186/441 (42%), Gaps = 59/441 (13%)

Query: 193 LMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVP 252
           L + +N I  +   +F+ +  L  L ++   +T I   A   LE+L S+    NRL+++ 
Sbjct: 53  LRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELG 112

Query: 253 HVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKE---LGINNMPELISIDSLAVDNLP 309
             +L+  VNL+ L L+ N + RI  G F + L   E   L  NN+ +   +    +  +P
Sbjct: 113 TGSLRGPVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQ---VPWAGIGAMP 169

Query: 310 DLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTI-------ESLPNLKE 362
            L  +   +N  +  + P AF +L +L  L L SN L+ L    +       E+ P    
Sbjct: 170 ALHTLNLDHN-LIDALPPGAFAQLGQLSRLDLTSNRLATLAPDPLFSRGRDAEASPAPLV 228

Query: 363 ISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSL-FCVDPPEFQGQNVRQVHFRDMMEICLP 421
           +S   NP+ C+C + W+       R   PD L  C  PP   G+    V          P
Sbjct: 229 LSFSGNPLHCNCELLWLR------RLARPDDLETCASPPGLAGRYFWAVP-EGEFSCEPP 281

Query: 422 LIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTL 481
           LIA  +    L V  G   +  CRA  +P P ++W+ P   +L+ N+   + +    GTL
Sbjct: 282 LIARHT--QRLWVLEGQRATLRCRALGDPAPTMHWVGPD-DRLVGNSSRARAF--PNGTL 336

Query: 482 DINGVTPKEGGLYTCIATNLVGADLKSVMIKV-----------DGSFP------------ 518
           +I      + G YTCIATN  G     V ++V           +G  P            
Sbjct: 337 EIGVTGAGDAGGYTCIATNPAGEATARVELRVLALPHGGNSSAEGGRPGPSDIAASARTA 396

Query: 519 QDNNGSLN----IKIRDIQANSVLVSWKASSKILKSSVKWTAFVKTENSHAAQSAR--IP 572
            +  G+L     +++ ++ A S LVSW        +   W   ++  +S         +P
Sbjct: 397 AEGEGTLESEPAVQVTEVTATSGLVSWGPGR---PADPVWMFQIQYNSSEDETLIYRIVP 453

Query: 573 SDVKVYNLTHLNPSTEYKICI 593
           +    + L HL P  +Y +C+
Sbjct: 454 ASSHHFLLKHLVPGADYDLCL 474



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 62/208 (29%), Positives = 91/208 (43%), Gaps = 15/208 (7%)

Query: 29  CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
           CP  C C+        ++    ST+ C   GLL  P  +   T  L L  N I  +    
Sbjct: 17  CPLPCVCQ--------NLSESLSTL-CAHRGLLFVPPNVDRRTVELRLADNFIQALG-PP 66

Query: 89  DFPVNLTGL---DLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
           DF  N+TGL    LS+N ++ +       +  L S++L+ N+L EL    L    NLQ L
Sbjct: 67  DFR-NMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQHL 125

Query: 146 YINHNLLSTISPGAFIG-LHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIK 204
            ++ N L  I+PGAF   L +L  L L+ N L+ +      A+P L  L +  N I  + 
Sbjct: 126 ILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDALP 185

Query: 205 DMNFKPLINLRSLVIAGINLTEIPDNAL 232
              F  L  L  L +    L  +  + L
Sbjct: 186 PGAFAQLGQLSRLDLTSNRLATLAPDPL 213


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score =  111 bits (278), Expect = 2e-24
 Identities = 108/470 (22%), Positives = 198/470 (42%), Gaps = 36/470 (7%)

Query: 47  YMEASTVDCNDLGLLTFPARLPA-NTQILLLQTNNIAKIE--YSTDFPVNLTGLDLSQNN 103
           +    T+D +   +       PA   + L L +N +  +E  Y  +    L  L L++N 
Sbjct: 144 FQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNR 203

Query: 104 LSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGL 163
           +S++    + K+PQL  + L  NK+  +       L  L+ L +  N ++ +  GAF GL
Sbjct: 204 ISAIPP-KMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGL 262

Query: 164 HNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGIN 223
            N+  L L+ N L  I   W   L  L+ L + +N I RI    ++    L  L +   +
Sbjct: 263 SNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNH 322

Query: 224 LTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNM 283
           L+ + D++ +GL  L ++   +NR+  +   A + + +LK LDL  N I+          
Sbjct: 323 LSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEIS---------- 372

Query: 284 LHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNS 343
                  I +M       + A   L  LR++    N R+  I   AF  L  LE L L+ 
Sbjct: 373 -----WTIEDM-------NGAFSGLDKLRRLILQGN-RIRSITKKAFTGLDALEHLDLSD 419

Query: 344 NALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQ 403
           NA+ +L       +  L+++ ++++ + CDC ++W+        F    +  C  P   +
Sbjct: 420 NAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLK 479

Query: 404 GQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQK 463
           G+++  V     +    P       P   +   GS +SF C A +     + +      +
Sbjct: 480 GRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNE 539

Query: 464 LLPNTLTDKF-YVHSEG--------TLDINGVTPKEGGLYTCIATNLVGA 504
           LL +   + + ++ ++G         L +  V     G Y C+ +N  G+
Sbjct: 540 LLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGS 589



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 113/496 (22%), Positives = 196/496 (39%), Gaps = 62/496 (12%)

Query: 69  ANTQILL-LQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENK 127
           ANT ++L L  N I+ I         L  L+L++N + +V  +  + +  L S+ ++ N 
Sbjct: 191 ANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNG 250

Query: 128 LTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN-SKW--- 183
           +T+L +     LSN++ L ++HN L+ I+ G   GL  L  LHL+ N +  I+   W   
Sbjct: 251 VTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC 310

Query: 184 --------------------FDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGIN 223
                               F  L  L  L IG N +  I D  F+ L +L++L +    
Sbjct: 311 QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNE 370

Query: 224 LT---EIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDF 280
           ++   E  + A  GL+ L  +    NR+  +   A   +  L+ LDL+ N I  ++   F
Sbjct: 371 ISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF 430

Query: 281 SNMLHLKELGINN-----------MPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNA 329
           S M  L++L +N            +P+ ++ ++            +      +  + P+ 
Sbjct: 431 SQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDG 490

Query: 330 FFR----------LPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIR-W 378
           F             P+ +S +  SN LS +      S   +       N +  D  +  +
Sbjct: 491 FVCDDFPKPQITVQPETQSAIKGSN-LSFICSAASSSDSPMTFAWKKDNELLHDAEMENY 549

Query: 379 MNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQV----HFRDMMEICLPLIAP--ESF---P 429
            ++       ME  ++  +   EF  +   Q     HF     +   L      SF   P
Sbjct: 550 AHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP 609

Query: 430 SNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSE-GTLDINGVTP 488
            +L + AG+     C A   P P+I W    G    P     + +V  E     I  V  
Sbjct: 610 MDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTD-FPAARERRMHVMPEDDVFFIVDVKI 668

Query: 489 KEGGLYTCIATNLVGA 504
           ++ G+Y+C A N  G+
Sbjct: 669 EDIGVYSCTAQNSAGS 684


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score =  111 bits (278), Expect = 2e-24
 Identities = 108/470 (22%), Positives = 198/470 (42%), Gaps = 36/470 (7%)

Query: 47  YMEASTVDCNDLGLLTFPARLPA-NTQILLLQTNNIAKIE--YSTDFPVNLTGLDLSQNN 103
           +    T+D +   +       PA   + L L +N +  +E  Y  +    L  L L++N 
Sbjct: 84  FQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNR 143

Query: 104 LSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGL 163
           +S++    + K+PQL  + L  NK+  +       L  L+ L +  N ++ +  GAF GL
Sbjct: 144 ISAIPP-KMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGL 202

Query: 164 HNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGIN 223
            N+  L L+ N L  I   W   L  L+ L + +N I RI    ++    L  L +   +
Sbjct: 203 SNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNH 262

Query: 224 LTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNM 283
           L+ + D++ +GL  L ++   +NR+  +   A + + +LK LDL  N I+          
Sbjct: 263 LSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEIS---------- 312

Query: 284 LHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNS 343
                  I +M       + A   L  LR++    N R+  I   AF  L  LE L L+ 
Sbjct: 313 -----WTIEDM-------NGAFSGLDKLRRLILQGN-RIRSITKKAFTGLDALEHLDLSD 359

Query: 344 NALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQ 403
           NA+ +L       +  L+++ ++++ + CDC ++W+        F    +  C  P   +
Sbjct: 360 NAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLK 419

Query: 404 GQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQK 463
           G+++  V     +    P       P   +   GS +SF C A +     + +      +
Sbjct: 420 GRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNE 479

Query: 464 LLPNTLTDKF-YVHSEG--------TLDINGVTPKEGGLYTCIATNLVGA 504
           LL +   + + ++ ++G         L +  V     G Y C+ +N  G+
Sbjct: 480 LLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGS 529



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 113/496 (22%), Positives = 196/496 (39%), Gaps = 62/496 (12%)

Query: 69  ANTQILL-LQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENK 127
           ANT ++L L  N I+ I         L  L+L++N + +V  +  + +  L S+ ++ N 
Sbjct: 131 ANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNG 190

Query: 128 LTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN-SKW--- 183
           +T+L +     LSN++ L ++HN L+ I+ G   GL  L  LHL+ N +  I+   W   
Sbjct: 191 VTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC 250

Query: 184 --------------------FDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGIN 223
                               F  L  L  L IG N +  I D  F+ L +L++L +    
Sbjct: 251 QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNE 310

Query: 224 LT---EIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDF 280
           ++   E  + A  GL+ L  +    NR+  +   A   +  L+ LDL+ N I  ++   F
Sbjct: 311 ISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF 370

Query: 281 SNMLHLKELGINN-----------MPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNA 329
           S M  L++L +N            +P+ ++ ++            +      +  + P+ 
Sbjct: 371 SQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDG 430

Query: 330 FFR----------LPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIR-W 378
           F             P+ +S +  SN LS +      S   +       N +  D  +  +
Sbjct: 431 FVCDDFPKPQITVQPETQSAIKGSN-LSFICSAASSSDSPMTFAWKKDNELLHDAEMENY 489

Query: 379 MNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQV----HFRDMMEICLPLIAP--ESF---P 429
            ++       ME  ++  +   EF  +   Q     HF     +   L      SF   P
Sbjct: 490 AHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP 549

Query: 430 SNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSE-GTLDINGVTP 488
            +L + AG+     C A   P P+I W    G    P     + +V  E     I  V  
Sbjct: 550 MDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTD-FPAARERRMHVMPEDDVFFIVDVKI 608

Query: 489 KEGGLYTCIATNLVGA 504
           ++ G+Y+C A N  G+
Sbjct: 609 EDIGVYSCTAQNSAGS 624


>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
           sapiens]
          Length = 674

 Score =  110 bits (276), Expect = 3e-24
 Identities = 142/600 (23%), Positives = 241/600 (40%), Gaps = 131/600 (21%)

Query: 4   MPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTF 63
           M LR  + L   +   +  V     CP +C C+                + CND GL + 
Sbjct: 29  MDLRDWLFLCYGLIAFLTEVIDSTTCPSVCRCD-------------NGFIYCNDRGLTSI 75

Query: 64  PARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYL 123
           PA +P +   L LQ N I           N  G+     +L +  N+ V        +YL
Sbjct: 76  PADIPDDATTLYLQNNQI-----------NNAGIP---QDLKTKVNVQV--------IYL 113

Query: 124 EENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKW 183
            EN L E P   ++   +L+EL++  N + TI+  +   +  L +LHL+ N +  ++   
Sbjct: 114 YENDLDEFP---INLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVS--- 167

Query: 184 FDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLEN-LESIS 242
                              I++  F     L+ L ++  +L+ IP     GL + LE + 
Sbjct: 168 -------------------IEEDAFADSKQLKLLFLSRNHLSSIPS----GLPHTLEELR 204

Query: 243 FYDNRLIKVPHVALQKVVNLKFLDLNKNPI--NRIRRGDFSNMLHLKELGINNMPELISI 300
             DNR+  +P  A + + +L+ L L+ N +   RI    FS + +L EL +         
Sbjct: 205 LDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVR------- 257

Query: 301 DSLAVD--NLPD--LRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIES 356
           +SLA    NLP   L+K+   +N  +S+I  N   ++ +LE L L++N L+ L  G  + 
Sbjct: 258 NSLAAPPLNLPSAHLQKLYLQDNA-ISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDD 316

Query: 357 LPNLKEISIHSNPIRCDCVIRWM-NMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDM 415
           L NL ++ + +NP  C C + W+ +  K     +    L C  P + +G  ++ +     
Sbjct: 317 LGNLAQLLLRNNPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGMAIKDI--TSE 374

Query: 416 MEICLPLIAPESFPSN--LNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKF 473
           M+ C      E+ P     N  A +  S H  AT          TP G            
Sbjct: 375 MDECF-----ETGPQGGVANAAAKTTASNHASAT----------TPQG------------ 407

Query: 474 YVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQ 533
                    +  +  K  GL       L  +++   M   DG+       +L I ++ + 
Sbjct: 408 --------SLFTLKAKRPGL------RLPDSNIDYPMATGDGA------KTLAIHVKALT 447

Query: 534 ANSVLVSWKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICI 593
           A+S+ ++WKA+       + W     +    +     +  D   Y LT L P + Y IC+
Sbjct: 448 ADSIRITWKATLPASSFRLSWLRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYIICM 507


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  110 bits (275), Expect = 4e-24
 Identities = 108/385 (28%), Positives = 158/385 (41%), Gaps = 72/385 (18%)

Query: 29  CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
           CPR C C             E+    C   GL   P   P++TQ+L              
Sbjct: 396 CPRACVC-----------VPESRHSSCEGCGLQAVPRGFPSDTQLL-------------- 430

Query: 89  DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYIN 148
                    DL +N+  SV       +  L+S++L+   + EL    L+ L  L  LY++
Sbjct: 431 ---------DLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLS 481

Query: 149 HNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNF 208
            N L+ +S  A  G   L  L+L  NR   +      ALP+L  L + +N + R+   + 
Sbjct: 482 DNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDL 541

Query: 209 KPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268
                LR + ++G  +TE+   AL     LE +    N+L +VP  AL+ +  L  L L+
Sbjct: 542 GRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLS 601

Query: 269 KNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPN 328
            NP+  +R G F              P   S+  L +            N+  L  I P 
Sbjct: 602 GNPLRALRDGAF-------------QPVGRSLQHLFL------------NSSGLEQICPG 636

Query: 329 AFFRL-PKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVI----RWMNMNK 383
           AF  L P L+SL L  N L AL    + SL  L+ I + SNP  CDC +    RW  +  
Sbjct: 637 AFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPLHRW--LTG 692

Query: 384 TNIRFMEPDSLFCVDPPEFQGQNVR 408
            N+R        C  PP  +GQ V+
Sbjct: 693 LNLRV----GATCATPPNARGQRVK 713



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 97/375 (25%), Positives = 149/375 (39%), Gaps = 66/375 (17%)

Query: 4   MPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTF 63
           +PL + +L+ L +    QA  ++  CP+ C C+                V C    L   
Sbjct: 10  VPLVLPLLVLLLLAPARQAAAQR--CPQACICD-----------NSRRHVACRYQNLTEV 56

Query: 64  PARLPANTQILLLQTNNIAKIEYSTDFPV-NLTGLDLSQNNLSSVTNINVKKMPQLLSVY 122
           P  +P  TQ L LQ N +  I  +    V +LT LDL    +  V     + + +LL + 
Sbjct: 57  PDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLN 116

Query: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182
           L  N L ELP++ L                         GL +L RL L  N L+ +   
Sbjct: 117 LASNHLRELPQEALD------------------------GLGSLRRLELEGNALEELRPG 152

Query: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESIS 242
            F AL  L  L +  N ++ +  M F+ L+ +R L ++   L+ +   AL GL  L  +S
Sbjct: 153 TFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLS 212

Query: 243 FYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDS 302
            + N L  +P   L +   L  L+L  NP+      D                       
Sbjct: 213 LHHNELQALPGPVLSQARGLARLELGHNPLTYAGEED----------------------G 250

Query: 303 LAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKE 362
           LA   LP LR++   +   L  + P AF   P+L +L L  N L  L    ++    L+ 
Sbjct: 251 LA---LPGLREL-LLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTL--PPLQGPGQLRR 304

Query: 363 ISIHSNPIRCDCVIR 377
           + +  NP+ C C  R
Sbjct: 305 LRLQGNPLWCGCQAR 319


>gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
           sapiens]
          Length = 522

 Score =  109 bits (273), Expect = 8e-24
 Identities = 86/313 (27%), Positives = 144/313 (46%), Gaps = 35/313 (11%)

Query: 121 VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN 180
           +Y E   LTE P      LS L  L + +N LS +  G F GL  L  L+L+ N +  + 
Sbjct: 50  LYCEALNLTEAPHN----LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQ 105

Query: 181 SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES 240
              F  L  ++ L +  N I ++ +  F+P+ NLRS+ ++   L  +  +   GL  L +
Sbjct: 106 GDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTT 165

Query: 241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGIN-------- 292
           +    N +  VP    Q   +LKFLD+  N +  + R  F+ +  L EL +         
Sbjct: 166 LHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVN 225

Query: 293 --NMPELISIDSL------------AVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLES 338
             + P LIS+ SL            ++D + +L K++ + N  + Y+ P+ F  +P L+S
Sbjct: 226 FAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGN-EIEYMEPHVFETVPHLQS 284

Query: 339 LMLNSNALSALYHGTIESLPNLKEISIHSNPIRCD----CVIRWMNMNKTNIRFMEPDSL 394
           L L+SN L+ +    + S  +L  I++  N   C      +  W+N    N +     +L
Sbjct: 285 LQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLN----NFQGRYDGNL 340

Query: 395 FCVDPPEFQGQNV 407
            C  P   QG++V
Sbjct: 341 QCASPEYAQGEDV 353



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 3/98 (3%)

Query: 56  NDLGLLTFPARLPANTQI--LLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVK 113
           NDL  + F A  P    +  L L+ N +A +  S D+  NL  +DLS N +  +     +
Sbjct: 219 NDLVKVNF-AHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFE 277

Query: 114 KMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNL 151
            +P L S+ L+ N+LT +  + L+   +L  + +  NL
Sbjct: 278 TVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315


>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
           sapiens]
          Length = 581

 Score =  109 bits (272), Expect = 1e-23
 Identities = 81/314 (25%), Positives = 142/314 (45%), Gaps = 34/314 (10%)

Query: 121 VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN 180
           VY E  KL E+P    +    L    + +N L  +    F GL+ L  L+L+ N +  I+
Sbjct: 45  VYCESQKLQEIPSSISAGCLGLS---LRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNID 101

Query: 181 SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES 240
              F+ +  L+ L++  N I    +  F+P+ NLR+L ++   L  +      GL  L S
Sbjct: 102 ENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLS 161

Query: 241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINN------- 293
           +    N L  +P    Q   NL+ LDL  N I  + R  F+ M+ LKEL + +       
Sbjct: 162 LHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLN 221

Query: 294 ---MPELISIDSLAVD-------------NLPDLRKIEATNNPRLSYIHPNAFFRLPKLE 337
               P L+S+ +L +                  L++++ + N   ++  P+ F  +P L+
Sbjct: 222 LALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQ 281

Query: 338 SLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCD----CVIRWMNMNKTNIRFMEPDS 393
            L L+SN L+ +    ++S  +L +IS+  N   C      ++ W+     + + +  ++
Sbjct: 282 RLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLK----SFKGLRENT 337

Query: 394 LFCVDPPEFQGQNV 407
           + C  P E QG NV
Sbjct: 338 IICASPKELQGVNV 351


>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
           sapiens]
          Length = 660

 Score =  109 bits (272), Expect = 1e-23
 Identities = 103/405 (25%), Positives = 176/405 (43%), Gaps = 88/405 (21%)

Query: 19  LVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQT 78
           L   V K + CP +C C+              + V CN+  L + P  +P    +L L  
Sbjct: 26  LYSQVSKLLACPSVCRCD-------------RNFVYCNERSLTSVPLGIPEGVTVLYLHN 72

Query: 79  NNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSE 138
           N I           N  G     +N+ SV            +VYL  N+L E P   ++ 
Sbjct: 73  NQI-----------NNAGFPAELHNVQSVH-----------TVYLYGNQLDEFP---MNL 107

Query: 139 LSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGEN 198
             N++ L++  N + TIS  A   L  L  LHL+ N +  +                   
Sbjct: 108 PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVG------------------ 149

Query: 199 PIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLE-NLESISFYDNRLIKVPHVALQ 257
               ++D  F+  I+L+ L ++  +L+ +P    VGL  +L+ +   +NR+  +  +A Q
Sbjct: 150 ----VEDGAFREAISLKLLFLSKNHLSSVP----VGLPVDLQELRVDENRIAVISDMAFQ 201

Query: 258 KVVNLKFLDLNKNPINR--IRRGDFSNMLHLKELGI--NNMPELISIDSLAVDNLPDLRK 313
            + +L+ L ++ N +    I  G FS++  LKE  I  N++       S    +LP    
Sbjct: 202 NLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSL-------SHPPPDLPGTHL 254

Query: 314 IEA-TNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRC 372
           I     + ++++I   AF  L KLE L +++N L  L  G  ++L NLK+++  +NP  C
Sbjct: 255 IRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFC 314

Query: 373 DCVIRWMN------MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVH 411
           DC I+W+        +  N+R        C  P + +G  VR+++
Sbjct: 315 DCSIKWVTEWLKYIPSSLNVR-----GFMCQGPEQVRGMAVRELN 354


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,699,370
Number of Sequences: 37866
Number of extensions: 1199742
Number of successful extensions: 7013
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 292
Number of HSP's successfully gapped in prelim test: 246
Number of HSP's that attempted gapping in prelim test: 2817
Number of HSP's gapped (non-prelim): 2309
length of query: 708
length of database: 18,247,518
effective HSP length: 109
effective length of query: 599
effective length of database: 14,120,124
effective search space: 8457954276
effective search space used: 8457954276
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press