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Search of human proteins with 153791630
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153791630 bromodomain and WD repeat domain containing 3
[Homo sapiens]
(1802 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153791630 bromodomain and WD repeat domain containing 3 [Homo... 3682 0.0
gi|16445438 bromodomain and WD repeat domain containing 1 isofor... 1882 0.0
gi|16445436 bromodomain and WD repeat domain containing 1 isofor... 1882 0.0
gi|34996489 pleckstrin homology domain interacting protein [Homo... 1882 0.0
gi|55956930 bromodomain and WD repeat domain containing 1 isofor... 155 4e-37
gi|32189425 WD repeat domain 69 [Homo sapiens] 120 1e-26
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 107 1e-22
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 107 1e-22
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 107 1e-22
gi|23199987 WD repeat domain 5B [Homo sapiens] 99 5e-20
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 97 1e-19
gi|16554629 WD repeat domain 5 [Homo sapiens] 96 4e-19
gi|16554627 WD repeat domain 5 [Homo sapiens] 96 4e-19
gi|21071067 TBP-associated factor 5 [Homo sapiens] 95 5e-19
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 95 7e-19
gi|113865883 WD repeat domain 38 [Homo sapiens] 93 3e-18
gi|19913367 transducin beta-like 1Y [Homo sapiens] 88 7e-17
gi|19913365 transducin beta-like 1Y [Homo sapiens] 88 7e-17
gi|15150805 transducin beta-like 1Y [Homo sapiens] 88 7e-17
gi|26665869 WD repeat domain 51B [Homo sapiens] 87 1e-16
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 87 2e-16
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 86 2e-16
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 86 2e-16
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 86 2e-16
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 84 9e-16
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 84 9e-16
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 84 1e-15
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 84 1e-15
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 84 1e-15
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 84 1e-15
>gi|153791630 bromodomain and WD repeat domain containing 3 [Homo
sapiens]
Length = 1802
Score = 3682 bits (9548), Expect = 0.0
Identities = 1802/1802 (100%), Positives = 1802/1802 (100%)
Query: 1 MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDL 60
MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDL
Sbjct: 1 MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDL 60
Query: 61 VAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGS 120
VAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGS
Sbjct: 61 VAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGS 120
Query: 121 AFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHL 180
AFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHL
Sbjct: 121 AFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHL 180
Query: 181 SSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAG 240
SSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAG
Sbjct: 181 SSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAG 240
Query: 241 SCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVK 300
SCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVK
Sbjct: 241 SCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVK 300
Query: 301 TMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELES 360
TMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELES
Sbjct: 301 TMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELES 360
Query: 361 HTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDK 420
HTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDK
Sbjct: 361 HTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDK 420
Query: 421 ITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRI 480
ITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRI
Sbjct: 421 ITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRI 480
Query: 481 ILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLF 540
ILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLF
Sbjct: 481 ILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLF 540
Query: 541 GFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTK 600
GFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTK
Sbjct: 541 GFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTK 600
Query: 601 FQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDL 660
FQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDL
Sbjct: 601 FQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDL 660
Query: 661 RLINEGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQM 720
RLINEGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQM
Sbjct: 661 RLINEGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQM 720
Query: 721 ATERDLMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEP 780
ATERDLMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEP
Sbjct: 721 ATERDLMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEP 780
Query: 781 SCGRSLRRTQRKRQHTYQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVEDP 840
SCGRSLRRTQRKRQHTYQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVEDP
Sbjct: 781 SCGRSLRRTQRKRQHTYQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVEDP 840
Query: 841 VVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKK 900
VVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKK
Sbjct: 841 VVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKK 900
Query: 901 PKQTRKKKGGLVSIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAV 960
PKQTRKKKGGLVSIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAV
Sbjct: 901 PKQTRKKKGGLVSIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAV 960
Query: 961 RKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESF 1020
RKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESF
Sbjct: 961 RKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESF 1020
Query: 1021 SIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDS 1080
SIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDS
Sbjct: 1021 SIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDS 1080
Query: 1081 SFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGA 1140
SFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGA
Sbjct: 1081 SFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGA 1140
Query: 1141 HSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFY 1200
HSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFY
Sbjct: 1141 HSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFY 1200
Query: 1201 RRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAE 1260
RRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAE
Sbjct: 1201 RRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAE 1260
Query: 1261 ERNSTDAEEDTEIVDLDSDGPGTSSGRKVKCRGRRQSLKCNPDAWKKQCKELLSLIYERE 1320
ERNSTDAEEDTEIVDLDSDGPGTSSGRKVKCRGRRQSLKCNPDAWKKQCKELLSLIYERE
Sbjct: 1261 ERNSTDAEEDTEIVDLDSDGPGTSSGRKVKCRGRRQSLKCNPDAWKKQCKELLSLIYERE 1320
Query: 1321 DSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVKETLE 1380
DSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVKETLE
Sbjct: 1321 DSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVKETLE 1380
Query: 1381 AGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEYKSAIQS 1440
AGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEYKSAIQS
Sbjct: 1381 AGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEYKSAIQS 1440
Query: 1441 QKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTSSPFSSPVS 1500
QKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTSSPFSSPVS
Sbjct: 1441 QKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTSSPFSSPVS 1500
Query: 1501 DAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPVKQDHSLDGPLT 1560
DAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPVKQDHSLDGPLT
Sbjct: 1501 DAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPVKQDHSLDGPLT 1560
Query: 1561 NGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELGSSLSSESTCG 1620
NGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELGSSLSSESTCG
Sbjct: 1561 NGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELGSSLSSESTCG 1620
Query: 1621 SDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWKTRGTGGRGRWGRWG 1680
SDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWKTRGTGGRGRWGRWG
Sbjct: 1621 SDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWKTRGTGGRGRWGRWG 1680
Query: 1681 RWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAKRARIADDEFDTMFSGR 1740
RWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAKRARIADDEFDTMFSGR
Sbjct: 1681 RWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAKRARIADDEFDTMFSGR 1740
Query: 1741 FSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGW 1800
FSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGW
Sbjct: 1741 FSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGW 1800
Query: 1801 NY 1802
NY
Sbjct: 1801 NY 1802
>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
[Homo sapiens]
Length = 2269
Score = 1882 bits (4875), Expect = 0.0
Identities = 966/1653 (58%), Positives = 1187/1653 (71%), Gaps = 101/1653 (6%)
Query: 8 IEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANAHI 67
IE+ELY+LIAR+L +GPC ++AQVLVQELE++QL+P+RLDWEG EH RS+E+LV +N H+
Sbjct: 14 IESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHV 73
Query: 68 PPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHR 127
PD+LL+IC+RIGP+LDKEIP S+ V +LLG GRQSLLR AKDC+ T+W GSAFAALHR
Sbjct: 74 APDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHR 133
Query: 128 GRPPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHLSSVYCVA 187
GRPPE+PVNY PPN+V I +QLTGCS F FP + YQHIKMH+RILGHLS+VYCVA
Sbjct: 134 GRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVA 193
Query: 188 FDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVR 247
FDR+G RIFTGSDDCLVKIW+T +GRLL+TLRGHSAEISDMAVNYENT+IAAGSCDK++R
Sbjct: 194 FDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIR 253
Query: 248 VWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDR 307
VWCLRTCAPVAVLQGH+ SITS+QF P KG+ RY+ STGADGT+CFWQW ++++KF R
Sbjct: 254 VWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPR 313
Query: 308 PVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVA 367
P+KFTE+ RPGVQ+ CSSFS GGMF+ TGSTDHVIR+Y+LG E PEKIAELESHTDKV +
Sbjct: 314 PLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDS 373
Query: 368 VQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVT 427
+QFCNNGD RF+SGSRDGTARIW+++Q EW+SI+LDMAT+++G +L S E++ K KVT
Sbjct: 374 IQFCNNGD--RFLSGSRDGTARIWRFEQLEWRSILLDMATRISG-DLSSEEERFMKPKVT 430
Query: 428 MVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHD 487
M+AW++ D+ V+TAVN+ +LKVWNS TGQLLH L GH DEVFVLE HPFD RI+LSAGHD
Sbjct: 431 MIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHD 490
Query: 488 GNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKY 547
G+IFIWD+ +GTK+++YFNMIEGQGHGAVFDCKFS DG HFACTDSHGHLL+FGFGCSK
Sbjct: 491 GSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKP 550
Query: 548 YEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPG 607
YEKIPDQMFFHTDYRPLIRD+NNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTK+QRLVPG
Sbjct: 551 YEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKYQRLVPG 610
Query: 608 RENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDE-----SILDGIIRELQREQDLRL 662
REN DE LIPQLGYVA DGEV+EQ+I QTND DE SILDG+IR+LQ++QD R+
Sbjct: 611 RENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRM 670
Query: 663 -INEGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMA 721
++ +P N + R ++DI S PNI LRR S Q+EGVRQMH NAPRSQ+A
Sbjct: 671 GADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRR-SGQVEGVRQMHQNAPRSQIA 729
Query: 722 TERDLMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPS 781
TERDL AW RRVVV E+ G+ R E+ R KG+ E +LY + +K+K + ++D
Sbjct: 730 TERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQLSHKSDSVVL 789
Query: 782 CGRSLRRTQRKRQHTYQTR--------SNIEHNSQASCQNSGVQEDSDSSSEEDETVGTS 833
+S +RT R++ Y R S E +S + S Q + SSEEDE S
Sbjct: 790 VSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSSEEDE--WRS 847
Query: 834 DASVEDPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQT-RQTTRKICSSSDE---- 888
D E SSSDSSS YSDWTADAGINLQPP R + R+ + CSSS++
Sbjct: 848 DRKSE------SYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIST 901
Query: 889 ENLKSLEERQKKPKQTRKKKGGLVSIAG------EPNEEWFAPQWILDTIPRRSPFVPQM 942
ENL + R+K+ K+ + KK L + E E+ P WI DT R+SPFVPQM
Sbjct: 902 ENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQM 961
Query: 943 GDELIYFRQGHEAYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCC 1002
GDE+IYFRQGHEAY+ AVR++ IY +N K+PW KMDLR+QE VKIVGI+YEVGPPTLCC
Sbjct: 962 GDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLCC 1021
Query: 1003 LKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAW 1062
LKLAF+DP +GK+ +SFSI+YHDMPDVIDFLVL QFY+EA++RNWQ DRFRSIIDDAW
Sbjct: 1022 LKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDAW 1081
Query: 1063 WFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVS 1122
WFGTV SQ+P+QP+YPDS FQCY V WDN E EK+SPWDMEPIP+ P+E+GA + V+
Sbjct: 1082 WFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISVT 1141
Query: 1123 QEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVV 1182
+EL LLYKPQ GEWG SRDEEC+R+I GI+ LL+LD A+ FA PVDL YP YCTVV
Sbjct: 1142 TDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVV 1201
Query: 1183 AYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFI 1242
AYPTDL TIR RL NRFYRR+SAL+WEVRYIEHNARTFNEP+S I ++AK +TD LL+FI
Sbjct: 1202 AYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFI 1261
Query: 1243 GDQSCTDILDTYNKIKAEERNSTDAEEDTEIVDLDSDGPGTSSGRKVKCRGRRQSLKCN- 1301
+Q CT+I + N + +E+N+ D + DSD P TSSGR+ G++ N
Sbjct: 1262 KNQHCTNISELSNTSENDEQNAEDLD--------DSDLPKTSSGRRRVHDGKKSIRATNY 1313
Query: 1302 -PDAWKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSE 1360
WKKQCKEL++LI++ EDSEPFRQP DL+ YP
Sbjct: 1314 VESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYP------------------------- 1348
Query: 1361 DYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLS 1420
DY+D+IDTP+DF TV+ETL+AGNY SPLEF KD+R IF+N+KAYT NK+S+IYSM LRLS
Sbjct: 1349 DYRDIIDTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLS 1408
Query: 1421 ALFESHIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKN 1480
ALFE +K I S++K + ++ R R + R + S K K++K Q
Sbjct: 1409 ALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQRQNCKGDSQPNKSIRNLKPKRLKSQ--- 1465
Query: 1481 DQNTSVSHARTSSPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAK 1540
T + SP S S A YL + SS SG+S D ++
Sbjct: 1466 ---TKIIPELVGSPTQSTSSRTA-----YLGTHKTSAGISSG-----VTSGDSSDSAESS 1512
Query: 1541 SFRNRVLPVKQDHSLDGPLTNG---DGREPRTGIKRKLLSASEEDENMGGEDKEKKETKE 1597
R R + P+TNG E + L S++ E +E+
Sbjct: 1513 ERRKR----------NRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSS 1562
Query: 1598 KSHLSTSESGELGSSLSSESTCGSDSDSESTSR 1630
+S LS S + + + +++ G S + R
Sbjct: 1563 RSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGR 1595
Score = 39.7 bits (91), Expect = 0.027
Identities = 24/61 (39%), Positives = 34/61 (55%), Gaps = 5/61 (8%)
Query: 1718 RGATRAKRARIADDE-----FDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTE 1772
R ++KR R++ D+ D S R R +IKTRNQGRRTV Y+D D+ + +
Sbjct: 2203 RRQRQSKRPRLSVDDNDWEDLDYAKSKRVLRRSKIKTRNQGRRTVRYHDGDDDRSLENVL 2262
Query: 1773 D 1773
D
Sbjct: 2263 D 2263
Score = 34.7 bits (78), Expect = 0.86
Identities = 46/237 (19%), Positives = 95/237 (40%), Gaps = 21/237 (8%)
Query: 1452 LRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTSSPFSSPVSDA------AEG 1505
L SS+SS S S + ++ + N V+ R + + PVS A A
Sbjct: 1540 LSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATR 1599
Query: 1506 LSLYLLDDEPDGPFSSSSFGGYSRSGNSHDP----GKAKSFRNRVLPVKQDHSLDGPLTN 1561
+YL D + + + +R+GN+ + + +++ +++S + +
Sbjct: 1600 KRVYLSDSDNNSLETGEILK--ARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCS 1657
Query: 1562 G---DGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELGSSLSSEST 1618
G R ++KLL SE+++++ E +E++ E L S S S++
Sbjct: 1658 GRKLPHRNASAVARKKLLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESEN 1717
Query: 1619 CGSDSDSESTSRTDQDYVDGDHDY------SKFIQTRPKRKLRKQHGNGKRNWKTRG 1669
S+S+S+ + +G + +KF++ + K H + +T G
Sbjct: 1718 RDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAG 1774
Score = 32.3 bits (72), Expect = 4.3
Identities = 20/73 (27%), Positives = 37/73 (50%), Gaps = 3/73 (4%)
Query: 1572 KRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELGSSLSSESTCGSDSDSESTSRT 1631
K K+LS SE+ E+ E++++++ K SG L + S C SD E+ +
Sbjct: 1815 KTKILSDSEDSES---EEQDREDGKCHKMEMNPISGNLNCDPIAMSQCSSDHGCETDLDS 1871
Query: 1632 DQDYVDGDHDYSK 1644
D D ++ +++ K
Sbjct: 1872 DDDKIEKPNNFMK 1884
>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
[Homo sapiens]
Length = 2320
Score = 1882 bits (4875), Expect = 0.0
Identities = 966/1653 (58%), Positives = 1187/1653 (71%), Gaps = 101/1653 (6%)
Query: 8 IEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANAHI 67
IE+ELY+LIAR+L +GPC ++AQVLVQELE++QL+P+RLDWEG EH RS+E+LV +N H+
Sbjct: 14 IESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHV 73
Query: 68 PPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHR 127
PD+LL+IC+RIGP+LDKEIP S+ V +LLG GRQSLLR AKDC+ T+W GSAFAALHR
Sbjct: 74 APDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHR 133
Query: 128 GRPPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHLSSVYCVA 187
GRPPE+PVNY PPN+V I +QLTGCS F FP + YQHIKMH+RILGHLS+VYCVA
Sbjct: 134 GRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVA 193
Query: 188 FDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVR 247
FDR+G RIFTGSDDCLVKIW+T +GRLL+TLRGHSAEISDMAVNYENT+IAAGSCDK++R
Sbjct: 194 FDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIR 253
Query: 248 VWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDR 307
VWCLRTCAPVAVLQGH+ SITS+QF P KG+ RY+ STGADGT+CFWQW ++++KF R
Sbjct: 254 VWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPR 313
Query: 308 PVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVA 367
P+KFTE+ RPGVQ+ CSSFS GGMF+ TGSTDHVIR+Y+LG E PEKIAELESHTDKV +
Sbjct: 314 PLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDS 373
Query: 368 VQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVT 427
+QFCNNGD RF+SGSRDGTARIW+++Q EW+SI+LDMAT+++G +L S E++ K KVT
Sbjct: 374 IQFCNNGD--RFLSGSRDGTARIWRFEQLEWRSILLDMATRISG-DLSSEEERFMKPKVT 430
Query: 428 MVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHD 487
M+AW++ D+ V+TAVN+ +LKVWNS TGQLLH L GH DEVFVLE HPFD RI+LSAGHD
Sbjct: 431 MIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHD 490
Query: 488 GNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKY 547
G+IFIWD+ +GTK+++YFNMIEGQGHGAVFDCKFS DG HFACTDSHGHLL+FGFGCSK
Sbjct: 491 GSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKP 550
Query: 548 YEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPG 607
YEKIPDQMFFHTDYRPLIRD+NNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTK+QRLVPG
Sbjct: 551 YEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKYQRLVPG 610
Query: 608 RENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDE-----SILDGIIRELQREQDLRL 662
REN DE LIPQLGYVA DGEV+EQ+I QTND DE SILDG+IR+LQ++QD R+
Sbjct: 611 RENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRM 670
Query: 663 -INEGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMA 721
++ +P N + R ++DI S PNI LRR S Q+EGVRQMH NAPRSQ+A
Sbjct: 671 GADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRR-SGQVEGVRQMHQNAPRSQIA 729
Query: 722 TERDLMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPS 781
TERDL AW RRVVV E+ G+ R E+ R KG+ E +LY + +K+K + ++D
Sbjct: 730 TERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQLSHKSDSVVL 789
Query: 782 CGRSLRRTQRKRQHTYQTR--------SNIEHNSQASCQNSGVQEDSDSSSEEDETVGTS 833
+S +RT R++ Y R S E +S + S Q + SSEEDE S
Sbjct: 790 VSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSSEEDE--WRS 847
Query: 834 DASVEDPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQT-RQTTRKICSSSDE---- 888
D E SSSDSSS YSDWTADAGINLQPP R + R+ + CSSS++
Sbjct: 848 DRKSE------SYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEIST 901
Query: 889 ENLKSLEERQKKPKQTRKKKGGLVSIAG------EPNEEWFAPQWILDTIPRRSPFVPQM 942
ENL + R+K+ K+ + KK L + E E+ P WI DT R+SPFVPQM
Sbjct: 902 ENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQM 961
Query: 943 GDELIYFRQGHEAYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCC 1002
GDE+IYFRQGHEAY+ AVR++ IY +N K+PW KMDLR+QE VKIVGI+YEVGPPTLCC
Sbjct: 962 GDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLCC 1021
Query: 1003 LKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAW 1062
LKLAF+DP +GK+ +SFSI+YHDMPDVIDFLVL QFY+EA++RNWQ DRFRSIIDDAW
Sbjct: 1022 LKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDAW 1081
Query: 1063 WFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVS 1122
WFGTV SQ+P+QP+YPDS FQCY V WDN E EK+SPWDMEPIP+ P+E+GA + V+
Sbjct: 1082 WFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISVT 1141
Query: 1123 QEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVV 1182
+EL LLYKPQ GEWG SRDEEC+R+I GI+ LL+LD A+ FA PVDL YP YCTVV
Sbjct: 1142 TDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVV 1201
Query: 1183 AYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFI 1242
AYPTDL TIR RL NRFYRR+SAL+WEVRYIEHNARTFNEP+S I ++AK +TD LL+FI
Sbjct: 1202 AYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFI 1261
Query: 1243 GDQSCTDILDTYNKIKAEERNSTDAEEDTEIVDLDSDGPGTSSGRKVKCRGRRQSLKCN- 1301
+Q CT+I + N + +E+N+ D + DSD P TSSGR+ G++ N
Sbjct: 1262 KNQHCTNISELSNTSENDEQNAEDLD--------DSDLPKTSSGRRRVHDGKKSIRATNY 1313
Query: 1302 -PDAWKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSE 1360
WKKQCKEL++LI++ EDSEPFRQP DL+ YP
Sbjct: 1314 VESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYP------------------------- 1348
Query: 1361 DYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLS 1420
DY+D+IDTP+DF TV+ETL+AGNY SPLEF KD+R IF+N+KAYT NK+S+IYSM LRLS
Sbjct: 1349 DYRDIIDTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLS 1408
Query: 1421 ALFESHIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKN 1480
ALFE +K I S++K + ++ R R + R + S K K++K Q
Sbjct: 1409 ALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQRQNCKGDSQPNKSIRNLKPKRLKSQ--- 1465
Query: 1481 DQNTSVSHARTSSPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAK 1540
T + SP S S A YL + SS SG+S D ++
Sbjct: 1466 ---TKIIPELVGSPTQSTSSRTA-----YLGTHKTSAGISSG-----VTSGDSSDSAESS 1512
Query: 1541 SFRNRVLPVKQDHSLDGPLTNG---DGREPRTGIKRKLLSASEEDENMGGEDKEKKETKE 1597
R R + P+TNG E + L S++ E +E+
Sbjct: 1513 ERRKR----------NRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSS 1562
Query: 1598 KSHLSTSESGELGSSLSSESTCGSDSDSESTSR 1630
+S LS S + + + +++ G S + R
Sbjct: 1563 RSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGR 1595
Score = 34.7 bits (78), Expect = 0.86
Identities = 46/237 (19%), Positives = 95/237 (40%), Gaps = 21/237 (8%)
Query: 1452 LRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTSSPFSSPVSDA------AEG 1505
L SS+SS S S + ++ + N V+ R + + PVS A A
Sbjct: 1540 LSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATR 1599
Query: 1506 LSLYLLDDEPDGPFSSSSFGGYSRSGNSHDP----GKAKSFRNRVLPVKQDHSLDGPLTN 1561
+YL D + + + +R+GN+ + + +++ +++S + +
Sbjct: 1600 KRVYLSDSDNNSLETGEILK--ARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCS 1657
Query: 1562 G---DGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELGSSLSSEST 1618
G R ++KLL SE+++++ E +E++ E L S S S++
Sbjct: 1658 GRKLPHRNASAVARKKLLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESEN 1717
Query: 1619 CGSDSDSESTSRTDQDYVDGDHDY------SKFIQTRPKRKLRKQHGNGKRNWKTRG 1669
S+S+S+ + +G + +KF++ + K H + +T G
Sbjct: 1718 RDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAG 1774
Score = 32.3 bits (72), Expect = 4.3
Identities = 20/73 (27%), Positives = 37/73 (50%), Gaps = 3/73 (4%)
Query: 1572 KRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELGSSLSSESTCGSDSDSESTSRT 1631
K K+LS SE+ E+ E++++++ K SG L + S C SD E+ +
Sbjct: 1815 KTKILSDSEDSES---EEQDREDGKCHKMEMNPISGNLNCDPIAMSQCSSDHGCETDLDS 1871
Query: 1632 DQDYVDGDHDYSK 1644
D D ++ +++ K
Sbjct: 1872 DDDKIEKPNNFMK 1884
>gi|34996489 pleckstrin homology domain interacting protein [Homo
sapiens]
Length = 1821
Score = 1882 bits (4874), Expect = 0.0
Identities = 935/1524 (61%), Positives = 1149/1524 (75%), Gaps = 84/1524 (5%)
Query: 6 TQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANA 65
+++ +ELY+LIARFL+ GPC ++AQVL++E+ E +L+PRR DW GKEH R++++LV
Sbjct: 9 SELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQNLVKYYR 68
Query: 66 HIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAAL 125
H+ PD+LL+IC R+GPLL++EIPQSVPGVQTLLG GRQSLLR K CK +W GSA AAL
Sbjct: 69 HLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWKGSALAAL 128
Query: 126 HRGRPPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHLSSVYC 185
H GRPPE PVNY PP++ + +R+L G R + P++ YQH+KMHKRILGHLSSVYC
Sbjct: 129 HCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILGHLSSVYC 188
Query: 186 VAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKV 245
V FDR+GRRIFTGSDDCLVKIWATDDGRLLATLRGH+AEISDMAVNYENT+IAAGSCDK+
Sbjct: 189 VTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKM 248
Query: 246 VRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFR 305
+RVWCLRTCAP+AVLQGHSASITS+QF P G+ RYL+STGADGTICFW W T+K
Sbjct: 249 IRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKIN 308
Query: 306 DRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKV 365
RP KFTER RPGVQ+ CSSFS+GGMF+ TGSTDH+IR+Y+ GS PEKI+ELE HTDKV
Sbjct: 309 PRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKV 368
Query: 366 VAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLK 425
++QF N S RFVSGSRDGTARIWQ++++EWKSI+LDMAT+ G NL EDKITK+K
Sbjct: 369 DSIQFSNT--SNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMK 426
Query: 426 VTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAG 485
VTMVAWDR+D TVITAVNN LKVWNS TGQL+H L GH+DEVFVLE HPFD R++ SAG
Sbjct: 427 VTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAG 486
Query: 486 HDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCS 545
HDGN+ +WDL RG KIR+YFNMIEGQGHGAVFDCK SPDG HFACTDSHGHLL+FGFG S
Sbjct: 487 HDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSS 546
Query: 546 KYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLV 605
Y+KI DQMFFH+DYRPLIRDANN+VLDEQTQQAPHLMPPPFLVDVDGNPHP+++QRLV
Sbjct: 547 SKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSRYQRLV 606
Query: 606 PGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINE 665
PGRENC++EQLIPQ+G ++G + QV+ QQ N Q+ S LD +I+ LQ+EQDLR E
Sbjct: 607 PGRENCREEQLIPQMGVTSSG----LNQVLSQQAN-QEISPLDSMIQRLQQEQDLRRSGE 661
Query: 666 GDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERD 725
+ N + G++ S + ++ S PN+ LRR S QIEGVRQMH+NAPRS++ATERD
Sbjct: 662 AGIS----NTSRLSRGSISSTS-EVHSPPNVGLRR-SGQIEGVRQMHSNAPRSEIATERD 715
Query: 726 LMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLY---------TVEKKKKPSYTTQRN 776
L+AWSRRVVV EL+ GV+ QEE RTAKG+ EI Y TV K+ K ++ +
Sbjct: 716 LVAWSRRVVVPELSAGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVPKENKIPTVSKNH 775
Query: 777 DYEPSCGRSLRRTQRKRQHTYQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDAS 836
+E + Q+ QH Y+TRS +E + S + E+ SSS+E E V S +
Sbjct: 776 AHEHFLDLGESKKQQTNQHNYRTRSALEETPRPSEE----IENGSSSSDEGEVVAVSGGT 831
Query: 837 VEDPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKS--- 893
E+ W S+ SSSD SS+YSDWTADAGINLQPPK+ + T+K SSSDEE
Sbjct: 832 SEEEERAWHSDGSSSDYSSDYSDWTADAGINLQPPKKVPKNKTKKAESSSDEEEESEKQK 891
Query: 894 ------------------LEERQKKPKQTRKKK--GGLVSIAGEPNEEWFAPQWILDTIP 933
+ ++KKPK+ ++K+ G ++ G EEW WI DTIP
Sbjct: 892 QKQIKKEKKKVNEEKDGPISPKKKKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTIP 951
Query: 934 RRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKY 993
RR PFVPQMGDE+ YFRQGHEAYV RK+KIYS+N +KQPW+KM+LREQE +KIVGIKY
Sbjct: 952 RRCPFVPQMGDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKY 1011
Query: 994 EVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDR 1053
EVG PTLCCLKLAFLDP +GK+TG SF++KYHDMPDVIDFLVL Q +++AK R W IGDR
Sbjct: 1012 EVGLPTLCCLKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQFDDAKYRRWNIGDR 1071
Query: 1054 FRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPD 1113
FRS+IDDAWWFGT+ESQ+P Q EYPDS FQCY+V WDN + EKMSPWDME IP FP+
Sbjct: 1072 FRSVIDDAWWFGTIESQEPLQLEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPE 1131
Query: 1114 EVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLS 1173
E+G VP++ E +L+YKP +GEWG + RDEECER++ GIN L++LD AS F PVDL
Sbjct: 1132 ELGTSVPLTDGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMTLDIASAFVAPVDLQ 1191
Query: 1174 AYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKI 1233
AYP+YCTVVAYPTDL+TI++RLENRFYRR+S+LMWEVRYIEHN RTFNEP SPIVK+AK
Sbjct: 1192 AYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKF 1251
Query: 1234 VTDVLLRFIGDQSCTDILDTYNKIKAEERNSTDAEEDTEIVDLDSDGPGTSSGRK----V 1289
VTD+LL FI DQ+C +I+ YN +K + + ++ EE D+D PGTS+ ++
Sbjct: 1252 VTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDSEDEEK------DADVPGTSTRKRKDHQP 1305
Query: 1290 KCRGRRQSLKCNPDAWKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQEQEGESSESVV 1349
+ R R ++ + AWKKQC+ELL+LI++ EDSEPFRQP DLL YP
Sbjct: 1306 RRRLRNRAQSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYP-------------- 1351
Query: 1350 PERQQDSSLSEDYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKK 1409
DY+D+IDTP+DF+TV+ETLEAGNY SP+E KDVR IF+NSKAYT +K+
Sbjct: 1352 -----------DYRDIIDTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKR 1400
Query: 1410 SRIYSMMLRLSALFESHIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKG 1469
SRIYSM LRLSA FE HI +++S+YKSA++ KR R++ R+ SSS+SSS A SP+
Sbjct: 1401 SRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNTITKRRKKRNRSSSVSSSAASSPER 1460
Query: 1470 KQKQMKLQPKNDQNTSVSHARTSS 1493
K++ +K Q K++ +TS T S
Sbjct: 1461 KKRILKPQLKSESSTSAFSTPTRS 1484
Score = 57.8 bits (138), Expect = 1e-07
Identities = 34/87 (39%), Positives = 50/87 (57%), Gaps = 13/87 (14%)
Query: 1722 RAKRARIAD-----DEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDND---NFVSTED 1773
R+ R +I D +EF+ + P ++TRNQGRRT YN+D + + +
Sbjct: 1740 RSNRKKIDDPIDEEEEFEELKGSE----PHMRTRNQGRRTAFYNEDDSEEEQRQLLFEDT 1795
Query: 1774 PLNLGTSRSGRVRKMTEKARVSHLMGW 1800
L GTS GRVRK+TEKA+ ++L+GW
Sbjct: 1796 SLTFGTSSRGRVRKLTEKAK-ANLIGW 1821
>gi|55956930 bromodomain and WD repeat domain containing 1 isoform C
[Homo sapiens]
Length = 120
Score = 155 bits (391), Expect = 4e-37
Identities = 70/103 (67%), Positives = 90/103 (87%)
Query: 8 IEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANAHI 67
IE+ELY+LIAR+L +GPC ++AQVLVQELE++QL+P+RLDWEG EH RS+E+LV +N H+
Sbjct: 14 IESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHV 73
Query: 68 PPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAK 110
PD+LL+IC+RIGP+LDKEIP S+ V +LLG GRQSLLR AK
Sbjct: 74 APDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAK 116
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 120 bits (301), Expect = 1e-26
Identities = 93/317 (29%), Positives = 153/317 (48%), Gaps = 35/317 (11%)
Query: 178 GHLSSVYCVAFDRS-GRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTL 236
GH + VY +AF+ G +I TGS D K+W+ + G+ T RGH+AEI ++ N ++TL
Sbjct: 132 GHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTL 191
Query: 237 IAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQ 296
+A GS D ++W ++ V L+GHSA I S+ F +T G +R +T + D T+ W
Sbjct: 192 VATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF--NTSG-DRIITGS-FDHTVVVWD 247
Query: 297 WHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIA 356
D K +IS +SF+ I TGS D +++ + + +A
Sbjct: 248 --------ADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW--DATNGKCVA 297
Query: 357 ELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPS 416
L H D+++ F G + + S DGTARI+ AT+ L
Sbjct: 298 TLTGHDDEILDSCFDYTGKLI--ATASADGTARIF------------SAATRKCIAKLEG 343
Query: 417 GEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPF 476
E +I+K ++++ ++T ++ ++W++ TGQ L L GH DE+F A +
Sbjct: 344 HEGEISK-----ISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSC-AFNY 397
Query: 477 DQRIILSAGHDGNIFIW 493
I+++ D IW
Sbjct: 398 KGNIVITGSKDNTCRIW 414
Score = 102 bits (254), Expect = 3e-21
Identities = 70/215 (32%), Positives = 105/215 (48%), Gaps = 16/215 (7%)
Query: 178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLI 237
GH + + ++F+ SG RI TGS D V +W D GR + L GH AEIS + N++ +LI
Sbjct: 217 GHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLI 276
Query: 238 AAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQW 297
GS DK ++W VA L GH I F T + + + ADGT
Sbjct: 277 LTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCF----DYTGKLIATASADGT------ 326
Query: 298 HVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAE 357
+ R G +IS SF+ G + TGS+D RI+ ++ + +
Sbjct: 327 -ARIFSAATRKCIAKLEGHEG-EISKISFNPQGNHLLTGSSDKTARIW--DAQTGQCLQV 382
Query: 358 LESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ 392
LE HTD++ + F G+ + ++GS+D T RIW+
Sbjct: 383 LEGHTDEIFSCAFNYKGNIV--ITGSKDNTCRIWR 415
Score = 61.6 bits (148), Expect = 7e-09
Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 6/122 (4%)
Query: 176 ILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENT 235
+ GH + FD +G+ I T S D +I++ + +A L GH EIS ++ N +
Sbjct: 299 LTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358
Query: 236 LIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGA-DGTICF 294
+ GS DK R+W +T + VL+GH+ I S F + KG + TG+ D T
Sbjct: 359 HLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAF--NYKGN---IVITGSKDNTCRI 413
Query: 295 WQ 296
W+
Sbjct: 414 WR 415
Score = 59.3 bits (142), Expect = 3e-08
Identities = 25/75 (33%), Positives = 39/75 (52%)
Query: 175 RILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYEN 234
++ GH + ++F+ G + TGS D +IW G+ L L GH+ EI A NY+
Sbjct: 340 KLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKG 399
Query: 235 TLIAAGSCDKVVRVW 249
++ GS D R+W
Sbjct: 400 NIVITGSKDNTCRIW 414
Score = 57.4 bits (137), Expect = 1e-07
Identities = 46/174 (26%), Positives = 77/174 (44%), Gaps = 22/174 (12%)
Query: 328 SGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGT 387
SG FIT GS D +++ S E++ LE H + V A+ F NN + +GS D T
Sbjct: 103 SGSCFIT-GSYDRTCKLWDTASG--EELNTLEGHRNVVYAIAF-NNPYGDKIATGSFDKT 158
Query: 388 ARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLL 447
++W + TG + + + ++++ T V T +
Sbjct: 159 CKLWSVE---------------TGKCYHTFRGHTAE--IVCLSFNPQSTLVATGSMDTTA 201
Query: 448 KVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKI 501
K+W+ G+ ++TL GH E+ L + RII + D + +WD D G K+
Sbjct: 202 KLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVVWDADTGRKV 254
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 107 bits (266), Expect = 1e-22
Identities = 90/355 (25%), Positives = 162/355 (45%), Gaps = 48/355 (13%)
Query: 170 IKMHKRILGHLSSVY-CVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDM 228
+K K + GH V C+ F G RI +GSDD +K+W+ G+ L TL GH+ +
Sbjct: 252 LKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--W 307
Query: 229 AVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGA 288
+ + +I +GS D+ ++VW T + L GH++++ + + + S
Sbjct: 308 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL------HEKRVVSGSR 361
Query: 289 DGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLG 348
D T+ W ++T + + R C + G + +G+ D +++++
Sbjct: 362 DATLRVWD--IETGQCLHVLMGHVAAVR------CVQYD--GRRVVSGAYDFMVKVW--D 409
Query: 349 SEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATK 408
E + L+ HT++V ++QF D + VSGS D + R+W + +
Sbjct: 410 PETETCLHTLQGHTNRVYSLQF----DGIHVVSGSLDTSIRVWDVETG-------NCIHT 458
Query: 409 MTGN-NLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDE 467
+TG+ +L SG + LK ++ D+TV K+W+ TGQ L TL G +
Sbjct: 459 LTGHQSLTSGME----LKDNILVSGNADSTV---------KIWDIKTGQCLQTLQGPNKH 505
Query: 468 VFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFS 522
+ F++ ++++ DG + +WDL G IRN + G G V+ + S
Sbjct: 506 QSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRAS 560
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 107 bits (266), Expect = 1e-22
Identities = 90/355 (25%), Positives = 162/355 (45%), Gaps = 48/355 (13%)
Query: 170 IKMHKRILGHLSSVY-CVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDM 228
+K K + GH V C+ F G RI +GSDD +K+W+ G+ L TL GH+ +
Sbjct: 370 LKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--W 425
Query: 229 AVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGA 288
+ + +I +GS D+ ++VW T + L GH++++ + + + S
Sbjct: 426 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL------HEKRVVSGSR 479
Query: 289 DGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLG 348
D T+ W ++T + + R C + G + +G+ D +++++
Sbjct: 480 DATLRVWD--IETGQCLHVLMGHVAAVR------CVQYD--GRRVVSGAYDFMVKVW--D 527
Query: 349 SEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATK 408
E + L+ HT++V ++QF D + VSGS D + R+W + +
Sbjct: 528 PETETCLHTLQGHTNRVYSLQF----DGIHVVSGSLDTSIRVWDVETG-------NCIHT 576
Query: 409 MTGN-NLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDE 467
+TG+ +L SG + LK ++ D+TV K+W+ TGQ L TL G +
Sbjct: 577 LTGHQSLTSGME----LKDNILVSGNADSTV---------KIWDIKTGQCLQTLQGPNKH 623
Query: 468 VFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFS 522
+ F++ ++++ DG + +WDL G IRN + G G V+ + S
Sbjct: 624 QSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRAS 678
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 107 bits (266), Expect = 1e-22
Identities = 90/355 (25%), Positives = 162/355 (45%), Gaps = 48/355 (13%)
Query: 170 IKMHKRILGHLSSVY-CVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDM 228
+K K + GH V C+ F G RI +GSDD +K+W+ G+ L TL GH+ +
Sbjct: 290 LKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--W 345
Query: 229 AVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGA 288
+ + +I +GS D+ ++VW T + L GH++++ + + + S
Sbjct: 346 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL------HEKRVVSGSR 399
Query: 289 DGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLG 348
D T+ W ++T + + R C + G + +G+ D +++++
Sbjct: 400 DATLRVWD--IETGQCLHVLMGHVAAVR------CVQYD--GRRVVSGAYDFMVKVW--D 447
Query: 349 SEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATK 408
E + L+ HT++V ++QF D + VSGS D + R+W + +
Sbjct: 448 PETETCLHTLQGHTNRVYSLQF----DGIHVVSGSLDTSIRVWDVETG-------NCIHT 496
Query: 409 MTGN-NLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDE 467
+TG+ +L SG + LK ++ D+TV K+W+ TGQ L TL G +
Sbjct: 497 LTGHQSLTSGME----LKDNILVSGNADSTV---------KIWDIKTGQCLQTLQGPNKH 543
Query: 468 VFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFS 522
+ F++ ++++ DG + +WDL G IRN + G G V+ + S
Sbjct: 544 QSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRAS 598
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 98.6 bits (244), Expect = 5e-20
Identities = 83/319 (26%), Positives = 142/319 (44%), Gaps = 30/319 (9%)
Query: 176 ILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENT 235
++GH +V V F +G + + S D L+ IW DG+ TL GH+ EISD+A + +++
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 236 LIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFW 295
+ + S DK +++W +R+ + L+GHS + FC + + + S D T+ W
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV----FCCNFNPPSNLIISGSFDETVKIW 152
Query: 296 QWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKI 355
+ VKT K + S P +S F+ G I +GS D + RI+ S K
Sbjct: 153 E--VKTGKCLK---TLSAHSDP---VSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKT 204
Query: 356 AELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLP 415
++ V V+F NG + ++ + D T ++W Y + K +
Sbjct: 205 L-VDDDNPPVSFVKFSPNGKYI--LTATLDNTLKLWDYSR--------GRCLKTYTGHKN 253
Query: 416 SGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHP 475
VT W +++ + L+ +WN T +++ L GH D V HP
Sbjct: 254 EKYCIFANFSVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHP 307
Query: 476 FDQRIILSA-GHDGNIFIW 493
+ I +A +D I +W
Sbjct: 308 TENLIASAALENDKTIKLW 326
Score = 87.8 bits (216), Expect = 9e-17
Identities = 62/228 (27%), Positives = 108/228 (47%), Gaps = 24/228 (10%)
Query: 171 KMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAV 230
K K + GH + V+C F+ I +GS D VKIW G+ L TL HS +S +
Sbjct: 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHF 175
Query: 231 NYENTLIAAGSCDKVVRVW------CLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLT 284
N +LI +GS D + R+W CL+T ++ + ++ ++F P+ K Y+
Sbjct: 176 NCSGSLIVSGSYDGLCRIWDAASGQCLKT-----LVDDDNPPVSFVKFSPNGK----YIL 226
Query: 285 STGADGTICFWQWHVKTMKFRDRPVK-FTERSRPGVQISCSSFSSGGMFITTGSTDHVIR 343
+ D T+ W + R R +K +T I + +GG +I +GS D+++
Sbjct: 227 TATLDNTLKLWDYS------RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY 280
Query: 344 IYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIW 391
I+ L + E + +L+ HTD V++ + + + D T ++W
Sbjct: 281 IWNL--QTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 82.0 bits (201), Expect = 5e-15
Identities = 85/341 (24%), Positives = 134/341 (39%), Gaps = 42/341 (12%)
Query: 107 RDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSA 166
++++D K+ L S+ A PE P NY +V T A S G SS+
Sbjct: 4 KESRDAKAQLALSSS--ANQSKEVPENP-NYALKCTLVGHTEAVSSVKFSPNGEWLASSS 60
Query: 167 YQHI---------KMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLAT 217
+ K K + GH + VA+ R+ + SDD +K+W G+ L T
Sbjct: 61 ADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKT 120
Query: 218 LRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTK 277
L+GHS + N + LI +GS D+ V++W ++T + L HS ++++ F
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHF----N 176
Query: 278 GTNRYLTSTGADGTICFWQ----WHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFI 333
+ + S DG W +KT+ D P +S FS G +I
Sbjct: 177 CSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP-----------PVSFVKFSPNGKYI 225
Query: 334 TTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQY 393
T + D+ ++++ K + + F G VSGS D IW
Sbjct: 226 LTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKW-IVSGSEDNLVYIWNL 284
Query: 394 QQQE-------WKSIVLDMATKMTGNNLPSG---EDKITKL 424
Q +E +V+ A T N + S DK KL
Sbjct: 285 QTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKL 325
Score = 77.8 bits (190), Expect = 9e-14
Identities = 69/288 (23%), Positives = 124/288 (43%), Gaps = 42/288 (14%)
Query: 214 LLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFC 273
L TL GH+ +S + + +A+ S D+++ +W L GH+ I+ + +
Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 274 PSTKGTNRYLTSTGADGTICFWQWH----VKTMKFRDRPVKFTERSRPGVQISCSSFSSG 329
+ L S D T+ W +KT+K + C +F+
Sbjct: 93 SDSSR----LVSASDDKTLKLWDVRSGKCLKTLKGHSN------------YVFCCNFNPP 136
Query: 330 GMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTAR 389
I +GS D ++I+ + + + + L +H+D V AV F +G + VSGS DG R
Sbjct: 137 SNLIISGSFDETVKIWEV--KTGKCLKTLSAHSDPVSAVHFNCSGSLI--VSGSYDGLCR 192
Query: 390 IWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKV 449
IW + ++D +N P V+ V + ++TA + LK+
Sbjct: 193 IWDAASGQCLKTLVD------DDNPP----------VSFVKFSPNGKYILTATLDNTLKL 236
Query: 450 WNSITGQLLHTLSGHDDEVFVLEAH--PFDQRIILSAGHDGNIFIWDL 495
W+ G+ L T +GH +E + + A+ + I+S D ++IW+L
Sbjct: 237 WDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 284
Score = 58.2 bits (139), Expect = 7e-08
Identities = 56/245 (22%), Positives = 109/245 (44%), Gaps = 33/245 (13%)
Query: 260 LQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGV 319
L GH+ +++S++F P+ +L S+ AD I W + D + T +
Sbjct: 37 LVGHTEAVSSVKFSPN----GEWLASSSADRLIIIWGAY-------DGKYEKTLYGH-NL 84
Query: 320 QISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRF 379
+IS ++SS + + S D ++++ + S + + L+ H++ V F N S
Sbjct: 85 EISDVAWSSDSSRLVSASDDKTLKLWDVRSG--KCLKTLKGHSNYVFCCNF--NPPSNLI 140
Query: 380 VSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVI 439
+SGS D T +IW+ + T L + D V+ V ++ + ++
Sbjct: 141 ISGSFDETVKIWEVK------------TGKCLKTLSAHSDP-----VSAVHFNCSGSLIV 183
Query: 440 TAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGT 499
+ + L ++W++ +GQ L TL D+ + + IL+A D + +WD RG
Sbjct: 184 SGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGR 243
Query: 500 KIRNY 504
++ Y
Sbjct: 244 CLKTY 248
Score = 56.2 bits (134), Expect = 3e-07
Identities = 43/154 (27%), Positives = 72/154 (46%), Gaps = 25/154 (16%)
Query: 350 EVPEKI-----AELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLD 404
EVPE L HT+ V +V+F NG+ L S S D IW +++ +
Sbjct: 24 EVPENPNYALKCTLVGHTEAVSSVKFSPNGEWL--ASSSADRLIIIWGAYDGKYEKTLY- 80
Query: 405 MATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGH 464
G+NL +++ VAW + +++A ++ LK+W+ +G+ L TL GH
Sbjct: 81 ------GHNL----------EISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGH 124
Query: 465 DDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRG 498
+ VF +P +I+S D + IW++ G
Sbjct: 125 SNYVFCCNFNP-PSNLIISGSFDETVKIWEVKTG 157
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 97.4 bits (241), Expect = 1e-19
Identities = 64/223 (28%), Positives = 101/223 (45%), Gaps = 17/223 (7%)
Query: 174 KRILGHLSSVYCVAFDR-SGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNY 232
+ I+ H S+V + + SGR + TG DDC V +W+ + + +L GH++ + + +N
Sbjct: 14 QEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNT 73
Query: 233 ENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTI 292
LI AGS +RVW L + L GH A+I S+ F P ++ S D I
Sbjct: 74 PEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHP----YGEFVASGSQDTNI 129
Query: 293 CFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVP 352
W K FR R + C FS G ++ + + DH ++++ L
Sbjct: 130 KLWDIRRKGCVFRYR--------GHSQAVRCLRFSPDGKWLASAADDHTVKLWDL--TAG 179
Query: 353 EKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQ 395
+ ++E HT V V+F N SGS D T R W ++
Sbjct: 180 KMMSEFPGHTGPVNVVEFHPN--EYLLASGSSDRTIRFWDLEK 220
Score = 62.8 bits (151), Expect = 3e-09
Identities = 28/100 (28%), Positives = 53/100 (53%)
Query: 175 RILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYEN 234
R GH +V C+ F G+ + + +DD VK+W G++++ GH+ ++ + +
Sbjct: 142 RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNE 201
Query: 235 TLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCP 274
L+A+GS D+ +R W L V+ ++G + S+ F P
Sbjct: 202 YLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP 241
Score = 60.1 bits (144), Expect = 2e-08
Identities = 73/315 (23%), Positives = 132/315 (41%), Gaps = 39/315 (12%)
Query: 85 KEIPQSVPGVQTLLGVGRQS---LLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPP 141
+EI V +L+ +G+ S L DC+ LW+ + + PV V+
Sbjct: 14 QEIVAHASNVSSLV-LGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
Query: 142 NVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDD 201
+ A +G R + + K+ + ++GH +++ + F G + +GS D
Sbjct: 73 TPEELIVAGSQSGSIRVWDL------EAAKILRTLMGHKANICSLDFHPYGEFVASGSQD 126
Query: 202 CLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQ 261
+K+W + RGHS + + + + +A+ + D V++W L ++
Sbjct: 127 TNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFP 186
Query: 262 GHSASITSIQFCPSTKGTNRYLTSTG-ADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQ 320
GH+ + ++F P N YL ++G +D TI FW KF+ V PG
Sbjct: 187 GHTGPVNVVEFHP-----NEYLLASGSSDRTIRFWDLE----KFQ---VVSCIEGEPG-P 233
Query: 321 ISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPE-----------KIAELESHTDKVVAVQ 369
+ F+ G + +G D +R+Y G E PE K+A+L D+++ V
Sbjct: 234 VRSVLFNPDGCCLYSGCQDS-LRVY--GWE-PERCFDVVLVNWGKVADLAICNDQLIGVA 289
Query: 370 FCNNGDSLRFVSGSR 384
F + S V +R
Sbjct: 290 FSQSNVSSYVVDLTR 304
Score = 54.7 bits (130), Expect = 8e-07
Identities = 56/233 (24%), Positives = 100/233 (42%), Gaps = 37/233 (15%)
Query: 328 SGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGT 387
+ G + TG D + ++ + P I L HT V +V+ N + L V+GS+ G+
Sbjct: 31 ASGRLLATGGDDCRVNLWSINK--PNCIMSLTGHTSPVESVRL-NTPEEL-IVAGSQSGS 86
Query: 388 ARIWQYQQQEWKSIVLDMATKMTGNNL-PSGEDKITKLKVTMVA-WD--------RY--- 434
R+W + + ++ + + P GE + + T + WD RY
Sbjct: 87 IRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGH 146
Query: 435 ------------DTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIIL 482
+ +A ++ +K+W+ G+++ GH V V+E HP ++ ++
Sbjct: 147 SQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHP-NEYLLA 205
Query: 483 SAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDG--NHFACTDS 533
S D I WDL++ + + IEG+ G V F+PDG + C DS
Sbjct: 206 SGSSDRTIRFWDLEKFQVV----SCIEGE-PGPVRSVLFNPDGCCLYSGCQDS 253
Score = 52.4 bits (124), Expect = 4e-06
Identities = 43/200 (21%), Positives = 77/200 (38%), Gaps = 26/200 (13%)
Query: 354 KIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNN 413
K+ E+ +H V ++ L +G D +W + + +TG+
Sbjct: 12 KLQEIVAHASNVSSLVLGKASGRL-LATGGDDCRVNLWSINKP-------NCIMSLTGHT 63
Query: 414 LPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEA 473
P V V + + ++ + ++VW+ ++L TL GH + L+
Sbjct: 64 SP----------VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDF 113
Query: 474 HPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDC-KFSPDGNHFACTD 532
HP+ + + S D NI +WD+ R + Y +GH C +FSPDG A
Sbjct: 114 HPYGE-FVASGSQDTNIKLWDIRRKGCVFRY------RGHSQAVRCLRFSPDGKWLASAA 166
Query: 533 SHGHLLLFGFGCSKYYEKIP 552
+ L+ K + P
Sbjct: 167 DDHTVKLWDLTAGKMMSEFP 186
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 95.5 bits (236), Expect = 4e-19
Identities = 84/324 (25%), Positives = 141/324 (43%), Gaps = 34/324 (10%)
Query: 176 ILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENT 235
+ GH +V V F +G + + S D L+KIW DG+ T+ GH ISD+A + ++
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 236 LIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFW 295
L+ + S DK +++W + + + L+GHS + FC + + + S D ++ W
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV----FCCNFNPQSNLIVSGSFDESVRIW 156
Query: 296 QWHVKTMK-FRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEK 354
VKT K + P S P +S F+ G I + S D + RI+ S K
Sbjct: 157 D--VKTGKCLKTLPA----HSDP---VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 355 IAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNL 414
++ V V+F NG + ++ + D T ++W Y + + K +
Sbjct: 208 TL-IDDDNPPVSFVKFSPNGKYI--LAATLDNTLKLWDYSKGK--------CLKTYTGHK 256
Query: 415 PSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAH 474
VT W +++ + L+ +WN T +++ L GH D V H
Sbjct: 257 NEKYCIFANFSVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310
Query: 475 PFDQRIILSAG--HDGNIFIWDLD 496
P + II SA +D I +W D
Sbjct: 311 P-TENIIASAALENDKTIKLWKSD 333
Score = 81.6 bits (200), Expect = 6e-15
Identities = 64/260 (24%), Positives = 110/260 (42%), Gaps = 44/260 (16%)
Query: 171 KMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAV 230
K K I GH + VA+ + + SDD +KIW G+ L TL+GHS +
Sbjct: 78 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137
Query: 231 NYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADG 290
N ++ LI +GS D+ VR+W ++T + L HS ++++ F + S+ DG
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF----NRDGSLIVSSSYDG 193
Query: 291 TICFWQWH----VKTMKFRDR-PVKFTERSRPGVQISCSSFS------------------ 327
W +KT+ D PV F + S G I ++
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 253
Query: 328 ---------------SGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCN 372
+GG +I +GS D+++ I+ L + E + +L+ HTD V++
Sbjct: 254 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL--QTKEIVQKLQGHTDVVISTACHP 311
Query: 373 NGDSLRFVSGSRDGTARIWQ 392
+ + + D T ++W+
Sbjct: 312 TENIIASAALENDKTIKLWK 331
Score = 78.2 bits (191), Expect = 7e-14
Identities = 68/285 (23%), Positives = 120/285 (42%), Gaps = 42/285 (14%)
Query: 217 TLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPST 276
TL GH+ +S + + +A+ S DK++++W + GH I+ + +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW---- 95
Query: 277 KGTNRYLTSTGADGTICFWQWH----VKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMF 332
+ L S D T+ W +KT+K + C +F+
Sbjct: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN------------YVFCCNFNPQSNL 143
Query: 333 ITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ 392
I +GS D +RI+ + + + + L +H+D V AV F N D VS S DG RIW
Sbjct: 144 IVSGSFDESVRIWDV--KTGKCLKTLPAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWD 199
Query: 393 YQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNS 452
+ ++D +N P V+ V + ++ A + LK+W+
Sbjct: 200 TASGQCLKTLID------DDNPP----------VSFVKFSPNGKYILAATLDNTLKLWDY 243
Query: 453 ITGQLLHTLSGHDDEVFVLEAH--PFDQRIILSAGHDGNIFIWDL 495
G+ L T +GH +E + + A+ + I+S D ++IW+L
Sbjct: 244 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 52.4 bits (124), Expect = 4e-06
Identities = 55/235 (23%), Positives = 89/235 (37%), Gaps = 67/235 (28%)
Query: 358 LESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSG 417
L HT V +V+F NG+ L S S D +IW +++ + SG
Sbjct: 41 LAGHTKAVSSVKFSPNGEWL--ASSSADKLIKIWGAYDGKFEKTI-------------SG 85
Query: 418 EDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHP-- 475
KL ++ VAW +++A ++ LK+W+ +G+ L TL GH + VF +P
Sbjct: 86 H----KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141
Query: 476 -------FDQRI--------------------------------ILSAGHDGNIFIWDLD 496
FD+ + I+S+ +DG IWD
Sbjct: 142 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 497 RGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFG---CSKYY 548
G ++ + + V KFSP+G + L L+ + C K Y
Sbjct: 202 SGQCLKTLID----DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 95.5 bits (236), Expect = 4e-19
Identities = 84/324 (25%), Positives = 141/324 (43%), Gaps = 34/324 (10%)
Query: 176 ILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENT 235
+ GH +V V F +G + + S D L+KIW DG+ T+ GH ISD+A + ++
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 236 LIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFW 295
L+ + S DK +++W + + + L+GHS + FC + + + S D ++ W
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV----FCCNFNPQSNLIVSGSFDESVRIW 156
Query: 296 QWHVKTMK-FRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEK 354
VKT K + P S P +S F+ G I + S D + RI+ S K
Sbjct: 157 D--VKTGKCLKTLPA----HSDP---VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 355 IAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNL 414
++ V V+F NG + ++ + D T ++W Y + + K +
Sbjct: 208 TL-IDDDNPPVSFVKFSPNGKYI--LAATLDNTLKLWDYSKGK--------CLKTYTGHK 256
Query: 415 PSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAH 474
VT W +++ + L+ +WN T +++ L GH D V H
Sbjct: 257 NEKYCIFANFSVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310
Query: 475 PFDQRIILSAG--HDGNIFIWDLD 496
P + II SA +D I +W D
Sbjct: 311 P-TENIIASAALENDKTIKLWKSD 333
Score = 81.6 bits (200), Expect = 6e-15
Identities = 64/260 (24%), Positives = 110/260 (42%), Gaps = 44/260 (16%)
Query: 171 KMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAV 230
K K I GH + VA+ + + SDD +KIW G+ L TL+GHS +
Sbjct: 78 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137
Query: 231 NYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADG 290
N ++ LI +GS D+ VR+W ++T + L HS ++++ F + S+ DG
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF----NRDGSLIVSSSYDG 193
Query: 291 TICFWQWH----VKTMKFRDR-PVKFTERSRPGVQISCSSFS------------------ 327
W +KT+ D PV F + S G I ++
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 253
Query: 328 ---------------SGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCN 372
+GG +I +GS D+++ I+ L + E + +L+ HTD V++
Sbjct: 254 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL--QTKEIVQKLQGHTDVVISTACHP 311
Query: 373 NGDSLRFVSGSRDGTARIWQ 392
+ + + D T ++W+
Sbjct: 312 TENIIASAALENDKTIKLWK 331
Score = 78.2 bits (191), Expect = 7e-14
Identities = 68/285 (23%), Positives = 120/285 (42%), Gaps = 42/285 (14%)
Query: 217 TLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPST 276
TL GH+ +S + + +A+ S DK++++W + GH I+ + +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW---- 95
Query: 277 KGTNRYLTSTGADGTICFWQWH----VKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMF 332
+ L S D T+ W +KT+K + C +F+
Sbjct: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN------------YVFCCNFNPQSNL 143
Query: 333 ITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ 392
I +GS D +RI+ + + + + L +H+D V AV F N D VS S DG RIW
Sbjct: 144 IVSGSFDESVRIWDV--KTGKCLKTLPAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWD 199
Query: 393 YQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNS 452
+ ++D +N P V+ V + ++ A + LK+W+
Sbjct: 200 TASGQCLKTLID------DDNPP----------VSFVKFSPNGKYILAATLDNTLKLWDY 243
Query: 453 ITGQLLHTLSGHDDEVFVLEAH--PFDQRIILSAGHDGNIFIWDL 495
G+ L T +GH +E + + A+ + I+S D ++IW+L
Sbjct: 244 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 52.4 bits (124), Expect = 4e-06
Identities = 55/235 (23%), Positives = 89/235 (37%), Gaps = 67/235 (28%)
Query: 358 LESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSG 417
L HT V +V+F NG+ L S S D +IW +++ + SG
Sbjct: 41 LAGHTKAVSSVKFSPNGEWL--ASSSADKLIKIWGAYDGKFEKTI-------------SG 85
Query: 418 EDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHP-- 475
KL ++ VAW +++A ++ LK+W+ +G+ L TL GH + VF +P
Sbjct: 86 H----KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141
Query: 476 -------FDQRI--------------------------------ILSAGHDGNIFIWDLD 496
FD+ + I+S+ +DG IWD
Sbjct: 142 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 497 RGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFG---CSKYY 548
G ++ + + V KFSP+G + L L+ + C K Y
Sbjct: 202 SGQCLKTLID----DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 95.1 bits (235), Expect = 5e-19
Identities = 67/250 (26%), Positives = 115/250 (46%), Gaps = 20/250 (8%)
Query: 174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYE 233
K + GH VY +F + + S+D V++W+ L +GH+ + D +
Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596
Query: 234 NTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTIC 293
+G D+V R+W P+ + GH A + +F P+ + Y+ + AD T+
Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN----SNYVATGSADRTVR 652
Query: 294 FWQWHVKTMKFRDRPVK-FTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVP 352
W V+ FT P I +FS G F+ TG+TD + ++ +G +
Sbjct: 653 LWD------VLNGNCVRIFTGHKGP---IHSLTFSPNGRFLATGATDGRVLLWDIGHGL- 702
Query: 353 EKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGN 412
+ EL+ HTD V +++F +G+ L SGS D T R+W + ++ + D T TG+
Sbjct: 703 -MVGELKGHTDTVCSLRFSRDGEIL--ASGSMDNTVRLWD-AIKAFEDLETDDFTTATGH 758
Query: 413 -NLPSGEDKI 421
NLP ++
Sbjct: 759 INLPENSQEL 768
Score = 62.8 bits (151), Expect = 3e-09
Identities = 47/196 (23%), Positives = 79/196 (40%), Gaps = 14/196 (7%)
Query: 102 RQSLLRDAKDCKSTLWNGSAFAALHRGRPPELPV--NYVKPPNVVNITSARQLTGCSRFG 159
R LL ++D LW+ F L + PV P ++ G R
Sbjct: 555 RNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSG-----GHDRVA 609
Query: 160 HIFPSSAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLR 219
++ + YQ +++ GHL+ V C F + + TGS D V++W +G +
Sbjct: 610 RLWATDHYQPLRI---FAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFT 666
Query: 220 GHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGT 279
GH I + + +A G+ D V +W + V L+GH+ ++ S++F
Sbjct: 667 GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRF----SRD 722
Query: 280 NRYLTSTGADGTICFW 295
L S D T+ W
Sbjct: 723 GEILASGSMDNTVRLW 738
Score = 57.8 bits (138), Expect = 1e-07
Identities = 69/301 (22%), Positives = 112/301 (37%), Gaps = 53/301 (17%)
Query: 198 GSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPV 257
G D V++W+ +L + + SD++ LI S D + R+ +T + +
Sbjct: 488 GFADSTVRVWSVTPKKLRSV-----KQASDLS------LIDKESDDVLERIMDEKTASEL 536
Query: 258 AVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKT----MKFRDRPVKFTE 313
+L GHS + F P YL S+ DGT+ W T K + PV T+
Sbjct: 537 KILYGHSGPVYGASFSPD----RNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQ 592
Query: 314 RSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNN 373
FS G + +G D V R++ P +I H V +F N
Sbjct: 593 ------------FSPYGYYFVSGGHDRVARLWATDHYQPLRI--FAGHLADVNCTRFHPN 638
Query: 374 GDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDR 433
+ + +GS D T R+W I TG+ P + + +
Sbjct: 639 SNYV--ATGSADRTVRLWDVLNGNCVRI-------FTGHKGP----------IHSLTFSP 679
Query: 434 YDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIW 493
+ T + + +W+ G ++ L GH D V L D I+ S D + +W
Sbjct: 680 NGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLR-FSRDGEILASGSMDNTVRLW 738
Query: 494 D 494
D
Sbjct: 739 D 739
Score = 45.4 bits (106), Expect = 5e-04
Identities = 67/301 (22%), Positives = 106/301 (35%), Gaps = 52/301 (17%)
Query: 230 VNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGAD 289
V +++LIA G D VRVW + P + AS S+ S R + A
Sbjct: 478 VTDDSSLIAGGFADSTVRVWSV---TPKKLRSVKQASDLSLIDKESDDVLERIMDEKTAS 534
Query: 290 GTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGS 349
+K + PV +SFS ++ + S D +R++ L
Sbjct: 535 --------ELKILYGHSGPVYG------------ASFSPDRNYLLSSSEDGTVRLWSL-- 572
Query: 350 EVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKM 409
+ + + H V QF G FVSG D AR+W + I +
Sbjct: 573 QTFTCLVGYKGHNYPVWDTQFSPYG--YYFVSGGHDRVARLWATDHYQPLRIFAGHLADV 630
Query: 410 TGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVF 469
+ VA D TV ++W+ + G + +GH +
Sbjct: 631 NCTRFHPNSN--------YVATGSADRTV---------RLWDVLNGNCVRIFTGHKGPIH 673
Query: 470 VLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGH-GAVFDCKFSPDGNHF 528
L P + R + + DG + +WD+ G + E +GH V +FS DG
Sbjct: 674 SLTFSP-NGRFLATGATDGRVLLWDIGHGLMVG------ELKGHTDTVCSLRFSRDGEIL 726
Query: 529 A 529
A
Sbjct: 727 A 727
Score = 40.0 bits (92), Expect = 0.021
Identities = 30/110 (27%), Positives = 51/110 (46%), Gaps = 11/110 (10%)
Query: 443 NNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIR 502
++ L ++ + T L L GH V+ P D+ +LS+ DG + +W L T +
Sbjct: 521 DDVLERIMDEKTASELKILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLV 579
Query: 503 NYFNMIEGQGHG-AVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKI 551
Y +GH V+D +FSP G +F S GH + + +Y+ +
Sbjct: 580 GY------KGHNYPVWDTQFSPYGYYFV---SGGHDRVARLWATDHYQPL 620
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 94.7 bits (234), Expect = 7e-19
Identities = 76/320 (23%), Positives = 142/320 (44%), Gaps = 29/320 (9%)
Query: 178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWAT-DDGRLLATLRGHSAEISDMAVNYENTL 236
GH VYC F +G + + D L+ +W D ATL+GHS + ++ N + ++
Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
Query: 237 IAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGA-DGTICFW 295
+ + S DK V VW T V L+GH++ + S P+ +G L TG+ DGT+ W
Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCY--PARRGPQ--LVCTGSDDGTVKLW 179
Query: 296 QWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKI 355
K + + Q+ +F+ I +G D+ I+++ L +
Sbjct: 180 DIRKKAA---------IQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN--KLT 228
Query: 356 AELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLP 415
+ H D V + + G L +S + D T R+W + K + K+ N+
Sbjct: 229 YTMRGHADSVTGLSLSSEGSYL--LSNAMDNTVRVWDVRPFAPK----ERCVKIFQGNVH 282
Query: 416 SGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHP 475
+ E + + +W + + + + VW++ + ++L+ L GH + + HP
Sbjct: 283 NFEKNLLR-----CSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP 337
Query: 476 FDQRIILSAGHDGNIFIWDL 495
D+ II+SA D +++ ++
Sbjct: 338 -DEPIIISASSDKRLYMGEI 356
Score = 70.5 bits (171), Expect = 1e-11
Identities = 73/330 (22%), Positives = 132/330 (40%), Gaps = 43/330 (13%)
Query: 250 CLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDRPV 309
C AP+ +L GH + +F P+ L S G D I W + D
Sbjct: 52 CSSLQAPIMLLSGHEGEVYCCKFHPN----GSTLASAGFDRLILLWN------VYGDCDN 101
Query: 310 KFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQ 369
T + G + +++ G + + STD + ++ SE E++ L+ HT V +
Sbjct: 102 YATLKGHSGAVMEL-HYNTDGSMLFSASTDKTVAVW--DSETGERVKRLKGHTSFVNSCY 158
Query: 370 FCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMV 429
G L +GS DGT ++W +++ A T N +V V
Sbjct: 159 PARRGPQL-VCTGSDDGTVKLWDIRKK---------AAIQTFQN---------TYQVLAV 199
Query: 430 AWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGN 489
++ +I+ + +KVW+ +L +T+ GH D V L + +LS D
Sbjct: 200 TFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSS-EGSYLLSNAMDNT 258
Query: 490 IFIWDLDRGTKIRNYFNMIEGQGHG---AVFDCKFSPDGNHFACTDSHGHLLLFGFGCSK 546
+ +WD+ + +G H + C +SPDG+ A + + ++ +
Sbjct: 259 VRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRR 318
Query: 547 YYEKIP------DQMFFHTDYRPLIRDANN 570
K+P +++ FH D P+I A++
Sbjct: 319 ILYKLPGHAGSINEVAFHPD-EPIIISASS 347
Score = 60.5 bits (145), Expect = 1e-08
Identities = 49/232 (21%), Positives = 100/232 (43%), Gaps = 18/232 (7%)
Query: 165 SAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAE 224
+ Y + + GH +V + ++ G +F+ S D V +W ++ G + L+GH++
Sbjct: 94 NVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSF 153
Query: 225 I-SDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYL 283
+ S L+ GS D V++W +R A + Q ++ + ++ F T+ +
Sbjct: 154 VNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTF----NDTSDQI 208
Query: 284 TSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIR 343
S G D I W R + +T R ++ S SS G ++ + + D+ +R
Sbjct: 209 ISGGIDNDIKVWD-------LRQNKLTYTMRGHAD-SVTGLSLSSEGSYLLSNAMDNTVR 260
Query: 344 IYYLGSEVPE----KIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIW 391
++ + P+ KI + H + ++ + D + +GS D +W
Sbjct: 261 VWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 92.8 bits (229), Expect = 3e-18
Identities = 83/310 (26%), Positives = 132/310 (42%), Gaps = 34/310 (10%)
Query: 179 HLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIA 238
H V AF G+ + TGS+D V W T G+LL L GH+ + + + L A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 239 AGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWH 298
+ SCD VR+W + + VL+GH S+ ++ F P +R L S G D + W
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPD----SRQLASGGWDKRVMLWDVQ 135
Query: 299 VKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAE- 357
M ++ R +Q S FS + TGS D + I+ L P +
Sbjct: 136 SGQM------LRLLVGHRDSIQ--SSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
Query: 358 LESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSG 417
LE H+ + + + +G SGS D T IW + S+++ + +T
Sbjct: 188 LEGHSANISCLCYSASG---LLASGSWDKTIHIW---KPTTSSLLIQLKGHVTW------ 235
Query: 418 EDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFD 477
V +A+ + + +A + ++KVW+ TG+ L TL G D P D
Sbjct: 236 --------VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTP-D 286
Query: 478 QRIILSAGHD 487
+I++S D
Sbjct: 287 GKILVSGAAD 296
Score = 72.0 bits (175), Expect = 5e-12
Identities = 54/217 (24%), Positives = 91/217 (41%), Gaps = 14/217 (6%)
Query: 175 RILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYEN 234
R+ GH V F G + S DC V++W + L L+GH + ++ + ++
Sbjct: 58 RLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDS 117
Query: 235 TLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICF 294
+A+G DK V +W +++ + +L GH SI S F P T L + D T+
Sbjct: 118 RQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSP----TVNCLATGSWDSTVHI 173
Query: 295 WQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEK 354
W + T V ISC +S+ G+ + +GS D I I+
Sbjct: 174 WDLRMVT-----PAVSHQALEGHSANISCLCYSASGL-LASGSWDKTIHIW--KPTTSSL 225
Query: 355 IAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIW 391
+ +L+ H V ++ F + D L S ++W
Sbjct: 226 LIQLKGHVTWVKSIAF--SPDELWLASAGYSRMVKVW 260
Score = 55.8 bits (133), Expect = 4e-07
Identities = 70/314 (22%), Positives = 115/314 (36%), Gaps = 55/314 (17%)
Query: 221 HSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTN 280
H E++ A + + ++ GS D V W R+ + L GH+ + +F P
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD----G 75
Query: 281 RYLTSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDH 340
S D T+ W V K R +K +RS + SFS + +G D
Sbjct: 76 HLFASASCDCTVRLWD--VARAKCL-RVLKGHQRS-----VETVSFSPDSRQLASGGWDK 127
Query: 341 VIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ-------- 392
+ ++ + S + + L H D + + F + L +GS D T IW
Sbjct: 128 RVMLWDVQSG--QMLRLLVGHRDSIQSSDFSPTVNCL--ATGSWDSTVHIWDLRMVTPAV 183
Query: 393 -YQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWN 451
+Q E S + L SG +WD+ + +W
Sbjct: 184 SHQALEGHSANISCLCYSASGLLASG------------SWDK------------TIHIWK 219
Query: 452 SITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQ 511
T LL L GH V + P D+ + SAG+ + +WD + G + +++
Sbjct: 220 PTTSSLLIQLKGHVTWVKSIAFSP-DELWLASAGYSRMVKVWDCNTGKCLETLKGVLD-- 276
Query: 512 GHGAVFDCKFSPDG 525
C F+PDG
Sbjct: 277 ---VAHTCAFTPDG 287
Score = 53.9 bits (128), Expect = 1e-06
Identities = 40/131 (30%), Positives = 62/131 (47%), Gaps = 14/131 (10%)
Query: 171 KMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLA------TLRGHSAE 224
+M + ++GH S+ F + + TGS D V IW D R++ L GHSA
Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW---DLRMVTPAVSHQALEGHSAN 194
Query: 225 ISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLT 284
IS + + + L+A+GS DK + +W T + + L+GH + SI F P +L
Sbjct: 195 ISCLCYS-ASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD----ELWLA 249
Query: 285 STGADGTICFW 295
S G + W
Sbjct: 250 SAGYSRMVKVW 260
Score = 32.3 bits (72), Expect = 4.3
Identities = 17/73 (23%), Positives = 35/73 (47%)
Query: 175 RILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYEN 234
++ GH++ V +AF + + +VK+W + G+ L TL+G A +
Sbjct: 228 QLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDG 287
Query: 235 TLIAAGSCDKVVR 247
++ +G+ D+ R
Sbjct: 288 KILVSGAADQTRR 300
Score = 31.2 bits (69), Expect = 9.5
Identities = 17/53 (32%), Positives = 27/53 (50%), Gaps = 5/53 (9%)
Query: 477 DQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFA 529
D +++L+ DG ++ W+ G + G G V C+FSPDG+ FA
Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRL-----GGHTGPVKFCRFSPDGHLFA 79
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 88.2 bits (217), Expect = 7e-17
Identities = 93/376 (24%), Positives = 157/376 (41%), Gaps = 55/376 (14%)
Query: 178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDD----GRLLATLR------GHSA---- 223
GH S V+ A++ + +GS D +IW ++ G LR GH
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236
Query: 224 EISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYL 283
+++ + N + TL+A GS D R+W + L H I ++++ + KG Y+
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKW--NKKG--NYV 291
Query: 284 TSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIR 343
S G D T W H K +F S P + + + M + STD I
Sbjct: 292 LSAGVDKTTIIWDAHTGEAK-----QQFPFHSAPALDVDWQN----NMTFASCSTDMCIH 342
Query: 344 IYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVL 403
+ LG + P K + HT++V A+++ +G + S S D T +IW +Q + V
Sbjct: 343 VCRLGCDHPVK--TFQGHTNEVNAIKWDPSG--MLLASCSDDMTLKIWSMKQD---ACVH 395
Query: 404 DMATK----MTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLH 459
D+ T P+G M+A +D+TV ++W+ G H
Sbjct: 396 DLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTV---------RLWDVEQGVCTH 446
Query: 460 TLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDC 519
TL H + V+ + P D + + S D + IW+ G+ + +Y QG G +F+
Sbjct: 447 TLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSY------QGTGGIFEV 499
Query: 520 KFSPDGNHFACTDSHG 535
++ G+ + S G
Sbjct: 500 CWNARGDKVGASASDG 515
Score = 58.2 bits (139), Expect = 7e-08
Identities = 68/322 (21%), Positives = 128/322 (39%), Gaps = 56/322 (17%)
Query: 188 FDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVR 247
++ G + GS D +IW T++G L +TL H I + N + + + DK
Sbjct: 243 WNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTI 301
Query: 248 VWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDR 307
+W T HSA + + N S D I HV + D
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDW-----QNNMTFASCSTDMCI-----HVCRLGC-DH 350
Query: 308 PVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVA 367
PVK + +++ + GM + + S D ++I+ + + + +L++H+ ++
Sbjct: 351 PVKTFQGHTN--EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA--CVHDLQAHSKEIYT 406
Query: 368 VQF-------CNNGDSLRFVSGSRDGTARIWQYQQ-------QEWKSIVLDMATKMTGNN 413
+++ N S+ S S D T R+W +Q + + V +A G
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKY 466
Query: 414 LPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEA 473
L SG ++D+Y + +WN+ +G L+H+ G +F +
Sbjct: 467 LASG------------SFDKY------------VHIWNTQSGSLVHSYQG-TGGIFEVCW 501
Query: 474 HPFDQRIILSAGHDGNIFIWDL 495
+ ++ SA DG++ + DL
Sbjct: 502 NARGDKVGASAS-DGSVCVLDL 522
Score = 53.1 bits (126), Expect = 2e-06
Identities = 37/131 (28%), Positives = 57/131 (43%), Gaps = 13/131 (9%)
Query: 174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEI-------S 226
K GH + V + +D SG + + SDD +KIW+ + L+ HS EI +
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 227 DMAVNYENT--LIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLT 284
A + N+ ++A+ S D VR+W + L H + S+ F P K YL
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGK----YLA 468
Query: 285 STGADGTICFW 295
S D + W
Sbjct: 469 SGSFDKYVHIW 479
Score = 37.4 bits (85), Expect = 0.13
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 1/73 (1%)
Query: 176 ILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENT 235
++ H VY VAF G+ + +GS D V IW T G L+ + +G + I ++ N
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGD 506
Query: 236 LIAAGSCDKVVRV 248
+ A + D V V
Sbjct: 507 KVGASASDGSVCV 519
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 88.2 bits (217), Expect = 7e-17
Identities = 93/376 (24%), Positives = 157/376 (41%), Gaps = 55/376 (14%)
Query: 178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDD----GRLLATLR------GHSA---- 223
GH S V+ A++ + +GS D +IW ++ G LR GH
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236
Query: 224 EISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYL 283
+++ + N + TL+A GS D R+W + L H I ++++ + KG Y+
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKW--NKKG--NYV 291
Query: 284 TSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIR 343
S G D T W H K +F S P + + + M + STD I
Sbjct: 292 LSAGVDKTTIIWDAHTGEAK-----QQFPFHSAPALDVDWQN----NMTFASCSTDMCIH 342
Query: 344 IYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVL 403
+ LG + P K + HT++V A+++ +G + S S D T +IW +Q + V
Sbjct: 343 VCRLGCDHPVK--TFQGHTNEVNAIKWDPSG--MLLASCSDDMTLKIWSMKQD---ACVH 395
Query: 404 DMATK----MTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLH 459
D+ T P+G M+A +D+TV ++W+ G H
Sbjct: 396 DLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTV---------RLWDVEQGVCTH 446
Query: 460 TLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDC 519
TL H + V+ + P D + + S D + IW+ G+ + +Y QG G +F+
Sbjct: 447 TLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSY------QGTGGIFEV 499
Query: 520 KFSPDGNHFACTDSHG 535
++ G+ + S G
Sbjct: 500 CWNARGDKVGASASDG 515
Score = 58.2 bits (139), Expect = 7e-08
Identities = 68/322 (21%), Positives = 128/322 (39%), Gaps = 56/322 (17%)
Query: 188 FDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVR 247
++ G + GS D +IW T++G L +TL H I + N + + + DK
Sbjct: 243 WNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTI 301
Query: 248 VWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDR 307
+W T HSA + + N S D I HV + D
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDW-----QNNMTFASCSTDMCI-----HVCRLGC-DH 350
Query: 308 PVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVA 367
PVK + +++ + GM + + S D ++I+ + + + +L++H+ ++
Sbjct: 351 PVKTFQGHTN--EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA--CVHDLQAHSKEIYT 406
Query: 368 VQF-------CNNGDSLRFVSGSRDGTARIWQYQQ-------QEWKSIVLDMATKMTGNN 413
+++ N S+ S S D T R+W +Q + + V +A G
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKY 466
Query: 414 LPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEA 473
L SG ++D+Y + +WN+ +G L+H+ G +F +
Sbjct: 467 LASG------------SFDKY------------VHIWNTQSGSLVHSYQG-TGGIFEVCW 501
Query: 474 HPFDQRIILSAGHDGNIFIWDL 495
+ ++ SA DG++ + DL
Sbjct: 502 NARGDKVGASAS-DGSVCVLDL 522
Score = 53.1 bits (126), Expect = 2e-06
Identities = 37/131 (28%), Positives = 57/131 (43%), Gaps = 13/131 (9%)
Query: 174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEI-------S 226
K GH + V + +D SG + + SDD +KIW+ + L+ HS EI +
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 227 DMAVNYENT--LIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLT 284
A + N+ ++A+ S D VR+W + L H + S+ F P K YL
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGK----YLA 468
Query: 285 STGADGTICFW 295
S D + W
Sbjct: 469 SGSFDKYVHIW 479
Score = 37.4 bits (85), Expect = 0.13
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 1/73 (1%)
Query: 176 ILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENT 235
++ H VY VAF G+ + +GS D V IW T G L+ + +G + I ++ N
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGD 506
Query: 236 LIAAGSCDKVVRV 248
+ A + D V V
Sbjct: 507 KVGASASDGSVCV 519
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 88.2 bits (217), Expect = 7e-17
Identities = 93/376 (24%), Positives = 157/376 (41%), Gaps = 55/376 (14%)
Query: 178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDD----GRLLATLR------GHSA---- 223
GH S V+ A++ + +GS D +IW ++ G LR GH
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236
Query: 224 EISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYL 283
+++ + N + TL+A GS D R+W + L H I ++++ + KG Y+
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKW--NKKG--NYV 291
Query: 284 TSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIR 343
S G D T W H K +F S P + + + M + STD I
Sbjct: 292 LSAGVDKTTIIWDAHTGEAK-----QQFPFHSAPALDVDWQN----NMTFASCSTDMCIH 342
Query: 344 IYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVL 403
+ LG + P K + HT++V A+++ +G + S S D T +IW +Q + V
Sbjct: 343 VCRLGCDHPVK--TFQGHTNEVNAIKWDPSG--MLLASCSDDMTLKIWSMKQD---ACVH 395
Query: 404 DMATK----MTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLH 459
D+ T P+G M+A +D+TV ++W+ G H
Sbjct: 396 DLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTV---------RLWDVEQGVCTH 446
Query: 460 TLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDC 519
TL H + V+ + P D + + S D + IW+ G+ + +Y QG G +F+
Sbjct: 447 TLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSY------QGTGGIFEV 499
Query: 520 KFSPDGNHFACTDSHG 535
++ G+ + S G
Sbjct: 500 CWNARGDKVGASASDG 515
Score = 58.2 bits (139), Expect = 7e-08
Identities = 68/322 (21%), Positives = 128/322 (39%), Gaps = 56/322 (17%)
Query: 188 FDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVR 247
++ G + GS D +IW T++G L +TL H I + N + + + DK
Sbjct: 243 WNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTI 301
Query: 248 VWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDR 307
+W T HSA + + N S D I HV + D
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDW-----QNNMTFASCSTDMCI-----HVCRLGC-DH 350
Query: 308 PVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVA 367
PVK + +++ + GM + + S D ++I+ + + + +L++H+ ++
Sbjct: 351 PVKTFQGHTN--EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA--CVHDLQAHSKEIYT 406
Query: 368 VQF-------CNNGDSLRFVSGSRDGTARIWQYQQ-------QEWKSIVLDMATKMTGNN 413
+++ N S+ S S D T R+W +Q + + V +A G
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKY 466
Query: 414 LPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEA 473
L SG ++D+Y + +WN+ +G L+H+ G +F +
Sbjct: 467 LASG------------SFDKY------------VHIWNTQSGSLVHSYQG-TGGIFEVCW 501
Query: 474 HPFDQRIILSAGHDGNIFIWDL 495
+ ++ SA DG++ + DL
Sbjct: 502 NARGDKVGASAS-DGSVCVLDL 522
Score = 53.1 bits (126), Expect = 2e-06
Identities = 37/131 (28%), Positives = 57/131 (43%), Gaps = 13/131 (9%)
Query: 174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEI-------S 226
K GH + V + +D SG + + SDD +KIW+ + L+ HS EI +
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 227 DMAVNYENT--LIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLT 284
A + N+ ++A+ S D VR+W + L H + S+ F P K YL
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGK----YLA 468
Query: 285 STGADGTICFW 295
S D + W
Sbjct: 469 SGSFDKYVHIW 479
Score = 37.4 bits (85), Expect = 0.13
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 1/73 (1%)
Query: 176 ILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENT 235
++ H VY VAF G+ + +GS D V IW T G L+ + +G + I ++ N
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGD 506
Query: 236 LIAAGSCDKVVRV 248
+ A + D V V
Sbjct: 507 KVGASASDGSVCV 519
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 87.0 bits (214), Expect = 1e-16
Identities = 87/334 (26%), Positives = 132/334 (39%), Gaps = 41/334 (12%)
Query: 208 ATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASI 267
AT+D L +GH A I+ + ++ +A S D + +W + A GH +
Sbjct: 4 ATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVV 63
Query: 268 TSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFS 327
TS+QF P L S D T+ W D+ KF+E + FS
Sbjct: 64 TSVQFSPH----GNLLASASRDRTVRLW--------IPDKRGKFSEFKAHTAPVRSVDFS 111
Query: 328 SGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGT 387
+ G F+ T S D I+++ + + + L HT V +F +G + VS S D T
Sbjct: 112 ADGQFLATASEDKSIKVWSMYRQ--RFLYSLYRHTHWVRCAKFSPDGRLI--VSCSEDKT 167
Query: 388 ARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLL 447
+IW D K NN V ++ T + +A ++ +
Sbjct: 168 IKIW------------DTTNKQCVNNFSDSVG-----FANFVDFNPSGTCIASAGSDQTV 210
Query: 448 KVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNM 507
KVW+ +LL H V + HP +++A DG + I DL G I
Sbjct: 211 KVWDVRVNKLLQHYQVHSGGVNCISFHP-SGNYLITASSDGTLKILDLLEGRLIYTL--- 266
Query: 508 IEGQGH-GAVFDCKFSPDGNHFACTDSHGHLLLF 540
QGH G VF FS G FA + +LL+
Sbjct: 267 ---QGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 69.7 bits (169), Expect = 2e-11
Identities = 68/331 (20%), Positives = 134/331 (40%), Gaps = 36/331 (10%)
Query: 164 SSAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSA 223
+SA + + + GH +++ + +G+++ T S D + +W GH
Sbjct: 2 ASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKD 61
Query: 224 EISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYL 283
++ + + L+A+ S D+ VR+W + + H+A + S+ F ++L
Sbjct: 62 VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF----SADGQFL 117
Query: 284 TSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIR 343
+ D +I W +R R + R V+ C+ FS G I + S D I+
Sbjct: 118 ATASEDKSIKVWS------MYRQRFLYSLYRHTHWVR--CAKFSPDGRLIVSCSEDKTIK 169
Query: 344 IYYLGSEVPEKIAELESHTDKVVAVQFCN-NGDSLRFVSGSRDGTARIWQYQQQEWKSIV 402
I+ + K + + +D V F + N S D T ++W + + +
Sbjct: 170 IW----DTTNKQC-VNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNK----L 220
Query: 403 LDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLS 462
L +G V +++ +ITA ++ LK+ + + G+L++TL
Sbjct: 221 LQHYQVHSGG-------------VNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQ 267
Query: 463 GHDDEVFVLEAHPFDQRIILSAGHDGNIFIW 493
GH VF + + + S G D + +W
Sbjct: 268 GHTGPVFTVSFSKGGE-LFASGGADTQVLLW 297
Score = 42.7 bits (99), Expect = 0.003
Identities = 28/111 (25%), Positives = 50/111 (45%), Gaps = 4/111 (3%)
Query: 186 VAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKV 245
V F+ SG I + D VK+W +LL + HS ++ ++ + + S D
Sbjct: 192 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
Query: 246 VRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQ 296
+++ L + LQGH+ + ++ F +KG S GAD + W+
Sbjct: 252 LKILDLLEGRLIYTLQGHTGPVFTVSF---SKG-GELFASGGADTQVLLWR 298
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 86.7 bits (213), Expect = 2e-16
Identities = 92/376 (24%), Positives = 158/376 (42%), Gaps = 55/376 (14%)
Query: 178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDD----GRLLATLR----------GHSA 223
GH S V+ A++ + +GS D +IW + G LR +
Sbjct: 167 GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNK 226
Query: 224 EISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYL 283
+++ + N E TL+A GS D R+W + + L H I ++++ + KG ++
Sbjct: 227 DVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKW--NKKG--NFI 281
Query: 284 TSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIR 343
S G D T W H K +F S P + + S ++ + STD I
Sbjct: 282 LSAGVDKTTIIWDAHTGEAK-----QQFPFHSAPALDVDWQSNNT----FASCSTDMCIH 332
Query: 344 IYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVL 403
+ LG + P I + HT++V A+++ G+ L S S D T +IW +Q + V
Sbjct: 333 VCKLGQDRP--IKTFQGHTNEVNAIKWDPTGNLL--ASCSDDMTLKIWSMKQD---NCVH 385
Query: 404 DMATK----MTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLH 459
D+ T P+G M+A +D+TV ++W+ G +H
Sbjct: 386 DLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTV---------RLWDVDRGICIH 436
Query: 460 TLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDC 519
TL+ H + V+ + P D R + S D + IW+ G + +Y +G G +F+
Sbjct: 437 TLTKHQEPVYSVAFSP-DGRYLASGSFDKCVHIWNTQTGALVHSY------RGTGGIFEV 489
Query: 520 KFSPDGNHFACTDSHG 535
++ G+ + S G
Sbjct: 490 CWNAAGDKVGASASDG 505
Score = 57.0 bits (136), Expect = 2e-07
Identities = 68/315 (21%), Positives = 126/315 (40%), Gaps = 42/315 (13%)
Query: 188 FDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVR 247
++ G + TGS D +IW T DG L +TL H I + N + I + DK
Sbjct: 233 WNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTI 291
Query: 248 VWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDR 307
+W T HSA + + +N S D I HV + +DR
Sbjct: 292 IWDAHTGEAKQQFPFHSAPALDVDW-----QSNNTFASCSTDMCI-----HVCKLG-QDR 340
Query: 308 PVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVA 367
P+K + +++ + G + + S D ++I+ + + + +L++H ++
Sbjct: 341 PIKTFQGHTN--EVNAIKWDPTGNLLASCSDDMTLKIWSMKQD--NCVHDLQAHNKEIYT 396
Query: 368 VQFCNNGD-------SLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDK 420
+++ G +L S S D T R+W + I + TK
Sbjct: 397 IKWSPTGPGTNNPNANLMLASASFDSTVRLWDVD----RGICIHTLTK------------ 440
Query: 421 ITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRI 480
+ V VA+ + + + + +WN+ TG L+H+ G +F + + ++
Sbjct: 441 -HQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKV 498
Query: 481 ILSAGHDGNIFIWDL 495
SA DG++ + DL
Sbjct: 499 GASAS-DGSVCVLDL 512
Score = 52.8 bits (125), Expect = 3e-06
Identities = 34/131 (25%), Positives = 56/131 (42%), Gaps = 13/131 (9%)
Query: 174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVN-- 231
K GH + V + +D +G + + SDD +KIW+ + L+ H+ EI + +
Sbjct: 343 KTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPT 402
Query: 232 -------YENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLT 284
N ++A+ S D VR+W + + L H + S+ F P RYL
Sbjct: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPD----GRYLA 458
Query: 285 STGADGTICFW 295
S D + W
Sbjct: 459 SGSFDKCVHIW 469
Score = 40.0 bits (92), Expect = 0.021
Identities = 27/74 (36%), Positives = 36/74 (48%), Gaps = 1/74 (1%)
Query: 179 HLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIA 238
H VY VAF GR + +GS D V IW T G L+ + RG + I ++ N +
Sbjct: 441 HQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVG 499
Query: 239 AGSCDKVVRVWCLR 252
A + D V V LR
Sbjct: 500 ASASDGSVCVLDLR 513
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 86.3 bits (212), Expect = 2e-16
Identities = 64/224 (28%), Positives = 108/224 (48%), Gaps = 29/224 (12%)
Query: 174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYE 233
K + GH SV C+ +D R I TGS D V++W + G +L TL H+ + + + +
Sbjct: 274 KVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAV--LHLRFS 329
Query: 234 NTLIAAGSCDKVVRVWCLRTCAPVA---VLQGHSASITSIQFCPSTKGTNRYLTSTGADG 290
N L+ S D+ + VW + + + VL GH A++ + F ++Y+ S D
Sbjct: 330 NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF------DDKYIVSASGDR 383
Query: 291 TICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSE 350
TI W T +F V+ + G I+C + + +GS+D+ IR++ + E
Sbjct: 384 TIKVWS--TSTCEF----VRTLNGHKRG--IACLQYRD--RLVVSGSSDNTIRLWDI--E 431
Query: 351 VPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQ 394
+ LE H + V ++F D+ R VSG+ DG ++W Q
Sbjct: 432 CGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQ 471
Score = 77.0 bits (188), Expect = 2e-13
Identities = 74/321 (23%), Positives = 133/321 (41%), Gaps = 54/321 (16%)
Query: 183 VYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSC 242
VYC+ +D +I +G D +KIW L L GH+ + + + Y+ +I GS
Sbjct: 243 VYCLQYD--DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSV--LCLQYDERVIVTGSS 298
Query: 243 DKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTM 302
D VRVW + T + L H+ ++ ++F +N + + D +I W T
Sbjct: 299 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRF------SNGLMVTCSKDRSIAVWDMASAT- 351
Query: 303 KFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHT 362
D ++ R G + + + +I + S D I+++ + E + L H
Sbjct: 352 ---DITLR---RVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW--STSTCEFVRTLNGHK 403
Query: 363 DKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKIT 422
+ +Q+ + VSGS D T R+W + ++ G +++
Sbjct: 404 RGIACLQYRDR----LVVSGSSDNTIRLWDIECGACLRVL-------------EGHEEL- 445
Query: 423 KLKVTMVAWDRYDTTVITAVNNFLLKVWN---------SITGQLLHTLSGHDDEVFVLEA 473
V + +D + +++ + +KVW+ + L TL H VF L+
Sbjct: 446 ---VRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQ- 499
Query: 474 HPFDQRIILSAGHDGNIFIWD 494
FD+ I+S+ HD I IWD
Sbjct: 500 --FDEFQIISSSHDDTILIWD 518
Score = 63.5 bits (153), Expect = 2e-09
Identities = 60/271 (22%), Positives = 109/271 (40%), Gaps = 51/271 (18%)
Query: 230 VNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGAD 289
+ Y++ I +G D +++W + + VL GH+ S+ +Q+ R + + +D
Sbjct: 246 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY------DERVIVTGSSD 299
Query: 290 GTICFWQWHVKTMKFRDRPVKFTE-----RSRPGVQISCSSFSSGGMFITTGSTDHVIRI 344
T+ W V T + + + E R G+ ++CS S ++ +TD +R
Sbjct: 300 STVRVWD--VNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRR 357
Query: 345 YYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLD 404
+G H V V F D VS S D T ++W E+
Sbjct: 358 VLVG------------HRAAVNVVDF----DDKYIVSASGDRTIKVWSTSTCEF------ 395
Query: 405 MATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGH 464
+ G+ K + D V++ ++ +++W+ G L L GH
Sbjct: 396 -VRTLNGH------------KRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGH 442
Query: 465 DDEVFVLEAHPFDQRIILSAGHDGNIFIWDL 495
++ V + FD + I+S +DG I +WDL
Sbjct: 443 EELVRCIR---FDNKRIVSGAYDGKIKVWDL 470
Score = 48.1 bits (113), Expect = 8e-05
Identities = 33/132 (25%), Positives = 62/132 (46%), Gaps = 22/132 (16%)
Query: 370 FCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMV 429
+C D + +SG RD + +IW E L + T TG+ V +
Sbjct: 244 YCLQYDDEKIISGLRDNSIKIWDKTSLE----CLKVLTGHTGS-------------VLCL 286
Query: 430 AWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGN 489
+D + ++T ++ ++VW+ TG++L+TL H++ V L F ++++ D +
Sbjct: 287 QYD--ERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLR---FSNGLMVTCSKDRS 341
Query: 490 IFIWDLDRGTKI 501
I +WD+ T I
Sbjct: 342 IAVWDMASATDI 353
Score = 43.5 bits (101), Expect = 0.002
Identities = 19/79 (24%), Positives = 41/79 (51%), Gaps = 3/79 (3%)
Query: 435 DTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWD 494
D +I+ + + +K+W+ + + L L+GH V L+ +D+R+I++ D + +WD
Sbjct: 250 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ---YDERVIVTGSSDSTVRVWD 306
Query: 495 LDRGTKIRNYFNMIEGQGH 513
++ G + + E H
Sbjct: 307 VNTGEVLNTLIHHNEAVLH 325
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 86.3 bits (212), Expect = 2e-16
Identities = 64/224 (28%), Positives = 108/224 (48%), Gaps = 29/224 (12%)
Query: 174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYE 233
K + GH SV C+ +D R I TGS D V++W + G +L TL H+ + + + +
Sbjct: 240 KVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAV--LHLRFS 295
Query: 234 NTLIAAGSCDKVVRVWCLRTCAPVA---VLQGHSASITSIQFCPSTKGTNRYLTSTGADG 290
N L+ S D+ + VW + + + VL GH A++ + F ++Y+ S D
Sbjct: 296 NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF------DDKYIVSASGDR 349
Query: 291 TICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSE 350
TI W T +F V+ + G I+C + + +GS+D+ IR++ + E
Sbjct: 350 TIKVWS--TSTCEF----VRTLNGHKRG--IACLQYRD--RLVVSGSSDNTIRLWDI--E 397
Query: 351 VPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQ 394
+ LE H + V ++F D+ R VSG+ DG ++W Q
Sbjct: 398 CGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQ 437
Score = 77.0 bits (188), Expect = 2e-13
Identities = 74/321 (23%), Positives = 133/321 (41%), Gaps = 54/321 (16%)
Query: 183 VYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSC 242
VYC+ +D +I +G D +KIW L L GH+ + + + Y+ +I GS
Sbjct: 209 VYCLQYD--DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSV--LCLQYDERVIVTGSS 264
Query: 243 DKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTM 302
D VRVW + T + L H+ ++ ++F +N + + D +I W T
Sbjct: 265 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRF------SNGLMVTCSKDRSIAVWDMASAT- 317
Query: 303 KFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHT 362
D ++ R G + + + +I + S D I+++ + E + L H
Sbjct: 318 ---DITLR---RVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW--STSTCEFVRTLNGHK 369
Query: 363 DKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKIT 422
+ +Q+ + VSGS D T R+W + ++ G +++
Sbjct: 370 RGIACLQYRDR----LVVSGSSDNTIRLWDIECGACLRVL-------------EGHEEL- 411
Query: 423 KLKVTMVAWDRYDTTVITAVNNFLLKVWN---------SITGQLLHTLSGHDDEVFVLEA 473
V + +D + +++ + +KVW+ + L TL H VF L+
Sbjct: 412 ---VRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQ- 465
Query: 474 HPFDQRIILSAGHDGNIFIWD 494
FD+ I+S+ HD I IWD
Sbjct: 466 --FDEFQIISSSHDDTILIWD 484
Score = 63.5 bits (153), Expect = 2e-09
Identities = 60/271 (22%), Positives = 109/271 (40%), Gaps = 51/271 (18%)
Query: 230 VNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGAD 289
+ Y++ I +G D +++W + + VL GH+ S+ +Q+ R + + +D
Sbjct: 212 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY------DERVIVTGSSD 265
Query: 290 GTICFWQWHVKTMKFRDRPVKFTE-----RSRPGVQISCSSFSSGGMFITTGSTDHVIRI 344
T+ W V T + + + E R G+ ++CS S ++ +TD +R
Sbjct: 266 STVRVWD--VNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRR 323
Query: 345 YYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLD 404
+G H V V F D VS S D T ++W E+
Sbjct: 324 VLVG------------HRAAVNVVDF----DDKYIVSASGDRTIKVWSTSTCEF------ 361
Query: 405 MATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGH 464
+ G+ K + D V++ ++ +++W+ G L L GH
Sbjct: 362 -VRTLNGH------------KRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGH 408
Query: 465 DDEVFVLEAHPFDQRIILSAGHDGNIFIWDL 495
++ V + FD + I+S +DG I +WDL
Sbjct: 409 EELVRCIR---FDNKRIVSGAYDGKIKVWDL 436
Score = 48.1 bits (113), Expect = 8e-05
Identities = 33/132 (25%), Positives = 62/132 (46%), Gaps = 22/132 (16%)
Query: 370 FCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMV 429
+C D + +SG RD + +IW E L + T TG+ V +
Sbjct: 210 YCLQYDDEKIISGLRDNSIKIWDKTSLE----CLKVLTGHTGS-------------VLCL 252
Query: 430 AWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGN 489
+D + ++T ++ ++VW+ TG++L+TL H++ V L F ++++ D +
Sbjct: 253 QYD--ERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLR---FSNGLMVTCSKDRS 307
Query: 490 IFIWDLDRGTKI 501
I +WD+ T I
Sbjct: 308 IAVWDMASATDI 319
Score = 43.5 bits (101), Expect = 0.002
Identities = 19/79 (24%), Positives = 41/79 (51%), Gaps = 3/79 (3%)
Query: 435 DTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWD 494
D +I+ + + +K+W+ + + L L+GH V L+ +D+R+I++ D + +WD
Sbjct: 216 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ---YDERVIVTGSSDSTVRVWD 272
Query: 495 LDRGTKIRNYFNMIEGQGH 513
++ G + + E H
Sbjct: 273 VNTGEVLNTLIHHNEAVLH 291
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 86.3 bits (212), Expect = 2e-16
Identities = 64/224 (28%), Positives = 108/224 (48%), Gaps = 29/224 (12%)
Query: 174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYE 233
K + GH SV C+ +D R I TGS D V++W + G +L TL H+ + + + +
Sbjct: 261 KVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAV--LHLRFS 316
Query: 234 NTLIAAGSCDKVVRVWCLRTCAPVA---VLQGHSASITSIQFCPSTKGTNRYLTSTGADG 290
N L+ S D+ + VW + + + VL GH A++ + F ++Y+ S D
Sbjct: 317 NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF------DDKYIVSASGDR 370
Query: 291 TICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSE 350
TI W T +F V+ + G I+C + + +GS+D+ IR++ + E
Sbjct: 371 TIKVWS--TSTCEF----VRTLNGHKRG--IACLQYRD--RLVVSGSSDNTIRLWDI--E 418
Query: 351 VPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQ 394
+ LE H + V ++F D+ R VSG+ DG ++W Q
Sbjct: 419 CGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQ 458
Score = 77.0 bits (188), Expect = 2e-13
Identities = 74/321 (23%), Positives = 133/321 (41%), Gaps = 54/321 (16%)
Query: 183 VYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSC 242
VYC+ +D +I +G D +KIW L L GH+ + + + Y+ +I GS
Sbjct: 230 VYCLQYD--DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSV--LCLQYDERVIVTGSS 285
Query: 243 DKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTM 302
D VRVW + T + L H+ ++ ++F +N + + D +I W T
Sbjct: 286 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRF------SNGLMVTCSKDRSIAVWDMASAT- 338
Query: 303 KFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHT 362
D ++ R G + + + +I + S D I+++ + E + L H
Sbjct: 339 ---DITLR---RVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW--STSTCEFVRTLNGHK 390
Query: 363 DKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKIT 422
+ +Q+ + VSGS D T R+W + ++ G +++
Sbjct: 391 RGIACLQYRDR----LVVSGSSDNTIRLWDIECGACLRVL-------------EGHEEL- 432
Query: 423 KLKVTMVAWDRYDTTVITAVNNFLLKVWN---------SITGQLLHTLSGHDDEVFVLEA 473
V + +D + +++ + +KVW+ + L TL H VF L+
Sbjct: 433 ---VRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQ- 486
Query: 474 HPFDQRIILSAGHDGNIFIWD 494
FD+ I+S+ HD I IWD
Sbjct: 487 --FDEFQIISSSHDDTILIWD 505
Score = 63.5 bits (153), Expect = 2e-09
Identities = 60/271 (22%), Positives = 109/271 (40%), Gaps = 51/271 (18%)
Query: 230 VNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGAD 289
+ Y++ I +G D +++W + + VL GH+ S+ +Q+ R + + +D
Sbjct: 233 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY------DERVIVTGSSD 286
Query: 290 GTICFWQWHVKTMKFRDRPVKFTE-----RSRPGVQISCSSFSSGGMFITTGSTDHVIRI 344
T+ W V T + + + E R G+ ++CS S ++ +TD +R
Sbjct: 287 STVRVWD--VNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRR 344
Query: 345 YYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLD 404
+G H V V F D VS S D T ++W E+
Sbjct: 345 VLVG------------HRAAVNVVDF----DDKYIVSASGDRTIKVWSTSTCEF------ 382
Query: 405 MATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGH 464
+ G+ K + D V++ ++ +++W+ G L L GH
Sbjct: 383 -VRTLNGH------------KRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGH 429
Query: 465 DDEVFVLEAHPFDQRIILSAGHDGNIFIWDL 495
++ V + FD + I+S +DG I +WDL
Sbjct: 430 EELVRCIR---FDNKRIVSGAYDGKIKVWDL 457
Score = 48.1 bits (113), Expect = 8e-05
Identities = 33/132 (25%), Positives = 62/132 (46%), Gaps = 22/132 (16%)
Query: 370 FCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMV 429
+C D + +SG RD + +IW E L + T TG+ V +
Sbjct: 231 YCLQYDDEKIISGLRDNSIKIWDKTSLE----CLKVLTGHTGS-------------VLCL 273
Query: 430 AWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGN 489
+D + ++T ++ ++VW+ TG++L+TL H++ V L F ++++ D +
Sbjct: 274 QYD--ERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLR---FSNGLMVTCSKDRS 328
Query: 490 IFIWDLDRGTKI 501
I +WD+ T I
Sbjct: 329 IAVWDMASATDI 340
Score = 43.5 bits (101), Expect = 0.002
Identities = 19/79 (24%), Positives = 41/79 (51%), Gaps = 3/79 (3%)
Query: 435 DTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWD 494
D +I+ + + +K+W+ + + L L+GH V L+ +D+R+I++ D + +WD
Sbjct: 237 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ---YDERVIVTGSSDSTVRVWD 293
Query: 495 LDRGTKIRNYFNMIEGQGH 513
++ G + + E H
Sbjct: 294 VNTGEVLNTLIHHNEAVLH 312
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 84.3 bits (207), Expect = 9e-16
Identities = 65/222 (29%), Positives = 109/222 (49%), Gaps = 30/222 (13%)
Query: 174 KRIL-GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNY 232
KRIL GH SV C+ +D R I TGS D V++W + G +L TL H + + + +
Sbjct: 300 KRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRF 355
Query: 233 ENTLIAAGSCDKVVRVWCLRTCAPVA---VLQGHSASITSIQFCPSTKGTNRYLTSTGAD 289
N ++ S D+ + VW + + + VL GH A++ + F ++Y+ S D
Sbjct: 356 NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF------DDKYIVSASGD 409
Query: 290 GTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGS 349
TI W+ T +F V+ + G I+C + + +GS+D+ IR++ +
Sbjct: 410 RTIKV--WNTSTCEF----VRTLNGHKRG--IACLQYRD--RLVVSGSSDNTIRLWDI-- 457
Query: 350 EVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIW 391
E + LE H + V ++F D+ R VSG+ DG ++W
Sbjct: 458 ECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVW 495
Score = 75.5 bits (184), Expect = 4e-13
Identities = 75/322 (23%), Positives = 132/322 (40%), Gaps = 56/322 (17%)
Query: 183 VYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSC 242
VYC+ +D ++I +G D +KIW + L GH+ + + + Y+ +I GS
Sbjct: 270 VYCLQYD--DQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQYDERVIITGSS 325
Query: 243 DKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTM 302
D VRVW + T + L H ++ ++F N + + D +I W
Sbjct: 326 DSTVRVWDVNTGEMLNTLIHHCEAVLHLRF------NNGMMVTCSKDRSIAVWD------ 373
Query: 303 KFRDRPVKFT-ERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESH 361
P T R G + + + +I + S D I+++ + E + L H
Sbjct: 374 --MASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW--NTSTCEFVRTLNGH 429
Query: 362 TDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKI 421
+ +Q+ + VSGS D T R+W + ++ G +++
Sbjct: 430 KRGIACLQYRDR----LVVSGSSDNTIRLWDIECGACLRVL-------------EGHEEL 472
Query: 422 TKLKVTMVAWDRYDTTVITAVNNFLLKVWNSI--------TGQL-LHTLSGHDDEVFVLE 472
V + +D + +++ + +KVW+ + G L L TL H VF L+
Sbjct: 473 ----VRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQ 526
Query: 473 AHPFDQRIILSAGHDGNIFIWD 494
FD+ I+S+ HD I IWD
Sbjct: 527 ---FDEFQIVSSSHDDTILIWD 545
Score = 64.3 bits (155), Expect = 1e-09
Identities = 60/271 (22%), Positives = 107/271 (39%), Gaps = 51/271 (18%)
Query: 230 VNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGAD 289
+ Y++ I +G D +++W T +L GH+ S+ +Q+ R + + +D
Sbjct: 273 LQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY------DERVIITGSSD 326
Query: 290 GTICFWQWHVKTMKFRDRPVKFTE-----RSRPGVQISCSSFSSGGMFITTGSTDHVIRI 344
T+ W V T + + + E R G+ ++CS S ++ TD +R
Sbjct: 327 STVRVWD--VNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR 384
Query: 345 YYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLD 404
+G H V V F D VS S D T ++W E+
Sbjct: 385 VLVG------------HRAAVNVVDF----DDKYIVSASGDRTIKVWNTSTCEF------ 422
Query: 405 MATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGH 464
+ G+ K + D V++ ++ +++W+ G L L GH
Sbjct: 423 -VRTLNGH------------KRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGH 469
Query: 465 DDEVFVLEAHPFDQRIILSAGHDGNIFIWDL 495
++ V + FD + I+S +DG I +WDL
Sbjct: 470 EELVRCIR---FDNKRIVSGAYDGKIKVWDL 497
Score = 51.2 bits (121), Expect = 9e-06
Identities = 41/142 (28%), Positives = 67/142 (47%), Gaps = 25/142 (17%)
Query: 360 SHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGED 419
S T K V +C D + VSG RD T +IW E K I+ T TG+
Sbjct: 264 SETSKGV---YCLQYDDQKIVSGLRDNTIKIWDKNTLECKRIL----TGHTGS------- 309
Query: 420 KITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQR 479
V + +D + +IT ++ ++VW+ TG++L+TL H + V L F+
Sbjct: 310 ------VLCLQYD--ERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLR---FNNG 358
Query: 480 IILSAGHDGNIFIWDLDRGTKI 501
++++ D +I +WD+ T I
Sbjct: 359 MMVTCSKDRSIAVWDMASPTDI 380
Score = 43.5 bits (101), Expect = 0.002
Identities = 18/79 (22%), Positives = 40/79 (50%), Gaps = 3/79 (3%)
Query: 435 DTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWD 494
D +++ + + +K+W+ T + L+GH V L+ +D+R+I++ D + +WD
Sbjct: 277 DQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQ---YDERVIITGSSDSTVRVWD 333
Query: 495 LDRGTKIRNYFNMIEGQGH 513
++ G + + E H
Sbjct: 334 VNTGEMLNTLIHHCEAVLH 352
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 84.3 bits (207), Expect = 9e-16
Identities = 65/222 (29%), Positives = 109/222 (49%), Gaps = 30/222 (13%)
Query: 174 KRIL-GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNY 232
KRIL GH SV C+ +D R I TGS D V++W + G +L TL H + + + +
Sbjct: 336 KRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRF 391
Query: 233 ENTLIAAGSCDKVVRVWCLRTCAPVA---VLQGHSASITSIQFCPSTKGTNRYLTSTGAD 289
N ++ S D+ + VW + + + VL GH A++ + F ++Y+ S D
Sbjct: 392 NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF------DDKYIVSASGD 445
Query: 290 GTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGS 349
TI W+ T +F V+ + G I+C + + +GS+D+ IR++ +
Sbjct: 446 RTIKV--WNTSTCEF----VRTLNGHKRG--IACLQYRD--RLVVSGSSDNTIRLWDI-- 493
Query: 350 EVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIW 391
E + LE H + V ++F D+ R VSG+ DG ++W
Sbjct: 494 ECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVW 531
Score = 75.5 bits (184), Expect = 4e-13
Identities = 75/322 (23%), Positives = 132/322 (40%), Gaps = 56/322 (17%)
Query: 183 VYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSC 242
VYC+ +D ++I +G D +KIW + L GH+ + + + Y+ +I GS
Sbjct: 306 VYCLQYD--DQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQYDERVIITGSS 361
Query: 243 DKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTM 302
D VRVW + T + L H ++ ++F N + + D +I W
Sbjct: 362 DSTVRVWDVNTGEMLNTLIHHCEAVLHLRF------NNGMMVTCSKDRSIAVWD------ 409
Query: 303 KFRDRPVKFT-ERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESH 361
P T R G + + + +I + S D I+++ + E + L H
Sbjct: 410 --MASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW--NTSTCEFVRTLNGH 465
Query: 362 TDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKI 421
+ +Q+ + VSGS D T R+W + ++ G +++
Sbjct: 466 KRGIACLQYRDR----LVVSGSSDNTIRLWDIECGACLRVL-------------EGHEEL 508
Query: 422 TKLKVTMVAWDRYDTTVITAVNNFLLKVWNSI--------TGQL-LHTLSGHDDEVFVLE 472
V + +D + +++ + +KVW+ + G L L TL H VF L+
Sbjct: 509 ----VRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQ 562
Query: 473 AHPFDQRIILSAGHDGNIFIWD 494
FD+ I+S+ HD I IWD
Sbjct: 563 ---FDEFQIVSSSHDDTILIWD 581
Score = 64.3 bits (155), Expect = 1e-09
Identities = 60/271 (22%), Positives = 107/271 (39%), Gaps = 51/271 (18%)
Query: 230 VNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGAD 289
+ Y++ I +G D +++W T +L GH+ S+ +Q+ R + + +D
Sbjct: 309 LQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY------DERVIITGSSD 362
Query: 290 GTICFWQWHVKTMKFRDRPVKFTE-----RSRPGVQISCSSFSSGGMFITTGSTDHVIRI 344
T+ W V T + + + E R G+ ++CS S ++ TD +R
Sbjct: 363 STVRVWD--VNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR 420
Query: 345 YYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLD 404
+G H V V F D VS S D T ++W E+
Sbjct: 421 VLVG------------HRAAVNVVDF----DDKYIVSASGDRTIKVWNTSTCEF------ 458
Query: 405 MATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGH 464
+ G+ K + D V++ ++ +++W+ G L L GH
Sbjct: 459 -VRTLNGH------------KRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGH 505
Query: 465 DDEVFVLEAHPFDQRIILSAGHDGNIFIWDL 495
++ V + FD + I+S +DG I +WDL
Sbjct: 506 EELVRCIR---FDNKRIVSGAYDGKIKVWDL 533
Score = 51.2 bits (121), Expect = 9e-06
Identities = 41/142 (28%), Positives = 67/142 (47%), Gaps = 25/142 (17%)
Query: 360 SHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGED 419
S T K V +C D + VSG RD T +IW E K I+ T TG+
Sbjct: 300 SETSKGV---YCLQYDDQKIVSGLRDNTIKIWDKNTLECKRIL----TGHTGS------- 345
Query: 420 KITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQR 479
V + +D + +IT ++ ++VW+ TG++L+TL H + V L F+
Sbjct: 346 ------VLCLQYD--ERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLR---FNNG 394
Query: 480 IILSAGHDGNIFIWDLDRGTKI 501
++++ D +I +WD+ T I
Sbjct: 395 MMVTCSKDRSIAVWDMASPTDI 416
Score = 43.5 bits (101), Expect = 0.002
Identities = 18/79 (22%), Positives = 40/79 (50%), Gaps = 3/79 (3%)
Query: 435 DTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWD 494
D +++ + + +K+W+ T + L+GH V L+ +D+R+I++ D + +WD
Sbjct: 313 DQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQ---YDERVIITGSSDSTVRVWD 369
Query: 495 LDRGTKIRNYFNMIEGQGH 513
++ G + + E H
Sbjct: 370 VNTGEMLNTLIHHCEAVLH 388
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 84.0 bits (206), Expect = 1e-15
Identities = 83/358 (23%), Positives = 150/358 (41%), Gaps = 39/358 (10%)
Query: 176 ILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEIS--DMAVNYE 233
I H V C AF R I T S D VKIW + G L+ T HS +++ +
Sbjct: 653 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 712
Query: 234 NTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTIC 293
+ L+A GS D +++W L + GH+ S+ +F P K L S ADGT+
Sbjct: 713 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----LLASCSADGTLK 768
Query: 294 FWQ-WHVKTMKFRDRPVKFTERSRP----GVQISCSSFSSGGMFITTGSTDHVIRIYYLG 348
W K + F P V + C S+S+ G I + + +I+
Sbjct: 769 LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN---KIFLWN 825
Query: 349 SEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ---------------- 392
++ K+A+ H V V F +G S F++ S D T R+W+
Sbjct: 826 TDSRSKVADCRGHLSWVHGVMFSPDGSS--FLTSSDDQTIRLWETKKVCKNSAVMLKQEV 883
Query: 393 ---YQQQEWKSIVLDMATKMTGNNLPSGE-DKITKLKVTMVAWDRYDTTVITAVNNFLLK 448
+Q+ E + +D ++ N +G+ D +T+ +V+ + + N ++
Sbjct: 884 DVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIE 943
Query: 449 VWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWD--LDRGTKIRNY 504
+ + ++ + H V+ ++ D++ ++S+ D I +W+ LD+ +R +
Sbjct: 944 ILELVNNRIFQSRFQHKKTVWHIQ-FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGH 1000
Score = 54.7 bits (130), Expect = 8e-07
Identities = 50/198 (25%), Positives = 81/198 (40%), Gaps = 25/198 (12%)
Query: 361 HTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDK 420
HTD V F +G R S D T ++++ + TG L E K
Sbjct: 614 HTDAVYHACFSEDGQ--RIASCGADKTLQVFKAE---------------TGEKLL--EIK 654
Query: 421 ITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRI 480
+ +V A+ D + T + +K+WNS+TG+L+HT H ++V +
Sbjct: 655 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 714
Query: 481 ILSAG-HDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLL 539
+L+ G D + +WDL++ F H C+FSPD A + G L L
Sbjct: 715 LLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNH-----CRFSPDDKLLASCSADGTLKL 769
Query: 540 FGFGCSKYYEKIPDQMFF 557
+ + + I + FF
Sbjct: 770 WDATSANERKSINVKQFF 787
Score = 47.8 bits (112), Expect = 1e-04
Identities = 44/209 (21%), Positives = 87/209 (41%), Gaps = 30/209 (14%)
Query: 326 FSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSG-SR 384
FS G I + D ++++ +E EK+ E+++H D+V+ F + RF++ S
Sbjct: 623 FSEDGQRIASCGADKTLQVFK--AETGEKLLEIKAHEDEVLCCAFSTDD---RFIATCSV 677
Query: 385 DGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNN 444
D +IW MTG + + ++ ++ + + T ++
Sbjct: 678 DKKVKIW---------------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSD 722
Query: 445 FLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLD-----RGT 499
LK+W+ + +T+ GH + V P D +++ S DG + +WD +
Sbjct: 723 CFLKLWDLNQKECRNTMFGHTNSVNHCRFSP-DDKLLASCSADGTLKLWDATSANERKSI 781
Query: 500 KIRNYFNMIEGQGHG---AVFDCKFSPDG 525
++ +F +E V C +S DG
Sbjct: 782 NVKQFFLNLEDPQEDMEVIVKCCSWSADG 810
Score = 43.1 bits (100), Expect = 0.002
Identities = 76/383 (19%), Positives = 140/383 (36%), Gaps = 72/383 (18%)
Query: 183 VYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSC 242
V C ++ G RI + + + +W TD +A RGH + + + + + + S
Sbjct: 801 VKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 859
Query: 243 DKVVRVW-CLRTCAPVAVLQGHSASIT---------------SIQFCPSTKGTNRYLTST 286
D+ +R+W + C AV+ + +Q G YLT
Sbjct: 860 DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE- 918
Query: 287 GADGTICFWQWHVKTMKFRDRPVK-----------FTERSRPGVQISCSSFSSGGMFITT 335
A + C H++ + F D F R + + F++ + +
Sbjct: 919 -AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 977
Query: 336 GSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ--- 392
S D I+++ + +K L H + V + N R +S S DGT ++W
Sbjct: 978 SSDDAEIQVW---NWQLDKCIFLRGHQETVKDFRLLKNS---RLLSWSFDGTVKVWNIIT 1031
Query: 393 --------------------YQQQEWKSIVLDMATKMTGNNL--PSGEDKITKLKVTMVA 430
+ ++ S D K+ +L P E + V A
Sbjct: 1032 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1091
Query: 431 WDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDE--------VFVLEAHPFDQRIIL 482
+ T + T +N +++WN G+LLH + +E V L P D ++++
Sbjct: 1092 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP-DGKMLI 1150
Query: 483 SAGHDGNIFIWDLDRGTKIRNYF 505
SAG G I W++ G + ++
Sbjct: 1151 SAG--GYIKWWNVVTGESSQTFY 1171
Score = 42.7 bits (99), Expect = 0.003
Identities = 36/130 (27%), Positives = 55/130 (42%), Gaps = 14/130 (10%)
Query: 174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYE 233
K + H +V + + S D KIW+ D L LRGH+ + A + +
Sbjct: 1036 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1095
Query: 234 NTLIAAGSCDKVVRVW------CLRTCAPVAV--LQGHSASITSIQFCPSTKGTNRYLTS 285
+TL+A G + +R+W L CAP++ H +T + F P K L S
Sbjct: 1096 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGK----MLIS 1151
Query: 286 TGADGTICFW 295
G G I +W
Sbjct: 1152 AG--GYIKWW 1159
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 84.0 bits (206), Expect = 1e-15
Identities = 83/358 (23%), Positives = 150/358 (41%), Gaps = 39/358 (10%)
Query: 176 ILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEIS--DMAVNYE 233
I H V C AF R I T S D VKIW + G L+ T HS +++ +
Sbjct: 642 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 701
Query: 234 NTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTIC 293
+ L+A GS D +++W L + GH+ S+ +F P K L S ADGT+
Sbjct: 702 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----LLASCSADGTLK 757
Query: 294 FWQ-WHVKTMKFRDRPVKFTERSRP----GVQISCSSFSSGGMFITTGSTDHVIRIYYLG 348
W K + F P V + C S+S+ G I + + +I+
Sbjct: 758 LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN---KIFLWN 814
Query: 349 SEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ---------------- 392
++ K+A+ H V V F +G S F++ S D T R+W+
Sbjct: 815 TDSRSKVADCRGHLSWVHGVMFSPDGSS--FLTSSDDQTIRLWETKKVCKNSAVMLKQEV 872
Query: 393 ---YQQQEWKSIVLDMATKMTGNNLPSGE-DKITKLKVTMVAWDRYDTTVITAVNNFLLK 448
+Q+ E + +D ++ N +G+ D +T+ +V+ + + N ++
Sbjct: 873 DVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIE 932
Query: 449 VWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWD--LDRGTKIRNY 504
+ + ++ + H V+ ++ D++ ++S+ D I +W+ LD+ +R +
Sbjct: 933 ILELVNNRIFQSRFQHKKTVWHIQ-FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGH 989
Score = 54.7 bits (130), Expect = 8e-07
Identities = 50/198 (25%), Positives = 81/198 (40%), Gaps = 25/198 (12%)
Query: 361 HTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDK 420
HTD V F +G R S D T ++++ + TG L E K
Sbjct: 603 HTDAVYHACFSEDGQ--RIASCGADKTLQVFKAE---------------TGEKLL--EIK 643
Query: 421 ITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRI 480
+ +V A+ D + T + +K+WNS+TG+L+HT H ++V +
Sbjct: 644 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 703
Query: 481 ILSAG-HDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLL 539
+L+ G D + +WDL++ F H C+FSPD A + G L L
Sbjct: 704 LLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNH-----CRFSPDDKLLASCSADGTLKL 758
Query: 540 FGFGCSKYYEKIPDQMFF 557
+ + + I + FF
Sbjct: 759 WDATSANERKSINVKQFF 776
Score = 47.8 bits (112), Expect = 1e-04
Identities = 44/209 (21%), Positives = 87/209 (41%), Gaps = 30/209 (14%)
Query: 326 FSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSG-SR 384
FS G I + D ++++ +E EK+ E+++H D+V+ F + RF++ S
Sbjct: 612 FSEDGQRIASCGADKTLQVFK--AETGEKLLEIKAHEDEVLCCAFSTDD---RFIATCSV 666
Query: 385 DGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNN 444
D +IW MTG + + ++ ++ + + T ++
Sbjct: 667 DKKVKIW---------------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSD 711
Query: 445 FLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLD-----RGT 499
LK+W+ + +T+ GH + V P D +++ S DG + +WD +
Sbjct: 712 CFLKLWDLNQKECRNTMFGHTNSVNHCRFSP-DDKLLASCSADGTLKLWDATSANERKSI 770
Query: 500 KIRNYFNMIEGQGHG---AVFDCKFSPDG 525
++ +F +E V C +S DG
Sbjct: 771 NVKQFFLNLEDPQEDMEVIVKCCSWSADG 799
Score = 43.1 bits (100), Expect = 0.002
Identities = 76/383 (19%), Positives = 140/383 (36%), Gaps = 72/383 (18%)
Query: 183 VYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSC 242
V C ++ G RI + + + +W TD +A RGH + + + + + + S
Sbjct: 790 VKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 848
Query: 243 DKVVRVW-CLRTCAPVAVLQGHSASIT---------------SIQFCPSTKGTNRYLTST 286
D+ +R+W + C AV+ + +Q G YLT
Sbjct: 849 DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE- 907
Query: 287 GADGTICFWQWHVKTMKFRDRPVK-----------FTERSRPGVQISCSSFSSGGMFITT 335
A + C H++ + F D F R + + F++ + +
Sbjct: 908 -AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 966
Query: 336 GSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ--- 392
S D I+++ + +K L H + V + N R +S S DGT ++W
Sbjct: 967 SSDDAEIQVW---NWQLDKCIFLRGHQETVKDFRLLKNS---RLLSWSFDGTVKVWNIIT 1020
Query: 393 --------------------YQQQEWKSIVLDMATKMTGNNL--PSGEDKITKLKVTMVA 430
+ ++ S D K+ +L P E + V A
Sbjct: 1021 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1080
Query: 431 WDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDE--------VFVLEAHPFDQRIIL 482
+ T + T +N +++WN G+LLH + +E V L P D ++++
Sbjct: 1081 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP-DGKMLI 1139
Query: 483 SAGHDGNIFIWDLDRGTKIRNYF 505
SAG G I W++ G + ++
Sbjct: 1140 SAG--GYIKWWNVVTGESSQTFY 1160
Score = 42.7 bits (99), Expect = 0.003
Identities = 36/130 (27%), Positives = 55/130 (42%), Gaps = 14/130 (10%)
Query: 174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYE 233
K + H +V + + S D KIW+ D L LRGH+ + A + +
Sbjct: 1025 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1084
Query: 234 NTLIAAGSCDKVVRVW------CLRTCAPVAV--LQGHSASITSIQFCPSTKGTNRYLTS 285
+TL+A G + +R+W L CAP++ H +T + F P K L S
Sbjct: 1085 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGK----MLIS 1140
Query: 286 TGADGTICFW 295
G G I +W
Sbjct: 1141 AG--GYIKWW 1148
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 84.0 bits (206), Expect = 1e-15
Identities = 71/323 (21%), Positives = 126/323 (39%), Gaps = 36/323 (11%)
Query: 172 MHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVN 231
+ + GH +V CV F + +++ +GS D + +W GH ++ + +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 232 YENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGT 291
L+A+GS DK VR+W V + H+A++ S+ FC + + D T
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFC----SDGQSFVTASDDKT 126
Query: 292 ICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEV 351
+ W H + F S+ + C+ FS G I + S D ++++ S
Sbjct: 127 VKVWATHRQKFLF--------SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR- 177
Query: 352 PEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTG 411
E + H V V F +G + + D T ++W + + + G
Sbjct: 178 -ECVHSYCEHGGFVTYVDFHPSGTCI--AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
Query: 412 NNL-PSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFV 470
+ PSG +ITA ++ LK+ + + G+LL+TL GH
Sbjct: 235 LSFHPSG------------------NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 276
Query: 471 LEAHPFDQRIILSAGHDGNIFIW 493
+ A S G D + +W
Sbjct: 277 V-AFSRTGEYFASGGSDEQVMVW 298
Score = 65.5 bits (158), Expect = 5e-10
Identities = 80/333 (24%), Positives = 127/333 (38%), Gaps = 43/333 (12%)
Query: 210 DDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITS 269
+D L +GH ++ + + +A+GS D + VW ++ + GH ++T
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 270 IQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSG 329
+ F PS L S D T+ W +VK R T RS F S
Sbjct: 67 VNFSPS----GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRS--------VHFCSD 114
Query: 330 GMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTAR 389
G T S D ++++ + + + L H + V +F +G + VS S D T +
Sbjct: 115 GQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLI--VSASDDKTVK 170
Query: 390 IWQYQQQEWKSIVLDMATKMTGNNL-PSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLK 448
+W +E + +T + PSG T +A D TV K
Sbjct: 171 LWDKSSRECVHSYCEHGGFVTYVDFHPSG---------TCIAAAGMDNTV---------K 212
Query: 449 VWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMI 508
VW+ T +LL H V L HP +++A D + I DL G +
Sbjct: 213 VWDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILDLMEGRLLYTL---- 267
Query: 509 EGQGH-GAVFDCKFSPDGNHFACTDSHGHLLLF 540
GH G FS G +FA S ++++
Sbjct: 268 --HGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 84.0 bits (206), Expect = 1e-15
Identities = 71/323 (21%), Positives = 126/323 (39%), Gaps = 36/323 (11%)
Query: 172 MHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVN 231
+ + GH +V CV F + +++ +GS D + +W GH ++ + +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 232 YENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGT 291
L+A+GS DK VR+W V + H+A++ S+ FC + + D T
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFC----SDGQSFVTASDDKT 126
Query: 292 ICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEV 351
+ W H + F S+ + C+ FS G I + S D ++++ S
Sbjct: 127 VKVWATHRQKFLF--------SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR- 177
Query: 352 PEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTG 411
E + H V V F +G + + D T ++W + + + G
Sbjct: 178 -ECVHSYCEHGGFVTYVDFHPSGTCI--AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
Query: 412 NNL-PSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFV 470
+ PSG +ITA ++ LK+ + + G+LL+TL GH
Sbjct: 235 LSFHPSG------------------NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 276
Query: 471 LEAHPFDQRIILSAGHDGNIFIW 493
+ A S G D + +W
Sbjct: 277 V-AFSRTGEYFASGGSDEQVMVW 298
Score = 65.5 bits (158), Expect = 5e-10
Identities = 80/333 (24%), Positives = 127/333 (38%), Gaps = 43/333 (12%)
Query: 210 DDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITS 269
+D L +GH ++ + + +A+GS D + VW ++ + GH ++T
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 270 IQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSG 329
+ F PS L S D T+ W +VK R T RS F S
Sbjct: 67 VNFSPS----GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRS--------VHFCSD 114
Query: 330 GMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTAR 389
G T S D ++++ + + + L H + V +F +G + VS S D T +
Sbjct: 115 GQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLI--VSASDDKTVK 170
Query: 390 IWQYQQQEWKSIVLDMATKMTGNNL-PSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLK 448
+W +E + +T + PSG T +A D TV K
Sbjct: 171 LWDKSSRECVHSYCEHGGFVTYVDFHPSG---------TCIAAAGMDNTV---------K 212
Query: 449 VWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMI 508
VW+ T +LL H V L HP +++A D + I DL G +
Sbjct: 213 VWDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILDLMEGRLLYTL---- 267
Query: 509 EGQGH-GAVFDCKFSPDGNHFACTDSHGHLLLF 540
GH G FS G +FA S ++++
Sbjct: 268 --HGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,214,766
Number of Sequences: 37866
Number of extensions: 3732182
Number of successful extensions: 30793
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 449
Number of HSP's successfully gapped in prelim test: 509
Number of HSP's that attempted gapping in prelim test: 19609
Number of HSP's gapped (non-prelim): 6855
length of query: 1802
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1685
effective length of database: 13,817,196
effective search space: 23281975260
effective search space used: 23281975260
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.