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Search of human proteins with 15150805
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15150805 transducin beta-like 1Y [Homo sapiens]
(522 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19913367 transducin beta-like 1Y [Homo sapiens] 1071 0.0
gi|19913365 transducin beta-like 1Y [Homo sapiens] 1071 0.0
gi|15150805 transducin beta-like 1Y [Homo sapiens] 1071 0.0
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 985 0.0
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 985 0.0
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 985 0.0
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 985 0.0
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 916 0.0
gi|239748962 PREDICTED: hypothetical protein XP_002346868 [Homo ... 187 2e-47
gi|239742982 PREDICTED: hypothetical protein XP_002342710 [Homo ... 187 2e-47
gi|239754401 PREDICTED: similar to transducin (beta)-like 1 X-li... 140 4e-33
gi|32189425 WD repeat domain 69 [Homo sapiens] 136 5e-32
gi|26665869 WD repeat domain 51B [Homo sapiens] 125 9e-29
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 125 1e-28
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] 124 3e-28
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens] 124 3e-28
gi|4757988 WD repeat domain 39 [Homo sapiens] 122 1e-27
gi|23199987 WD repeat domain 5B [Homo sapiens] 121 2e-27
gi|16554629 WD repeat domain 5 [Homo sapiens] 118 1e-26
gi|16554627 WD repeat domain 5 [Homo sapiens] 118 1e-26
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 117 2e-26
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 116 4e-26
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 116 4e-26
gi|21071067 TBP-associated factor 5 [Homo sapiens] 116 4e-26
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 111 1e-24
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 109 5e-24
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 109 5e-24
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 109 5e-24
gi|113865883 WD repeat domain 38 [Homo sapiens] 103 3e-22
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 103 5e-22
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 1071 bits (2770), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV
Sbjct: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
Query: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK
Sbjct: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
Query: 121 AATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES 180
AATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES
Sbjct: 121 AATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES 180
Query: 181 EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTS 240
EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTS
Sbjct: 181 EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTS 240
Query: 241 LDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTT 300
LDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTT
Sbjct: 241 LDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTT 300
Query: 301 IIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTN 360
IIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTN
Sbjct: 301 IIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTN 360
Query: 361 EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPN 420
EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPN
Sbjct: 361 EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPN 420
Query: 421 SSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480
SSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN
Sbjct: 421 SSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480
Query: 481 TQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
TQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL
Sbjct: 481 TQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 1071 bits (2770), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV
Sbjct: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
Query: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK
Sbjct: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
Query: 121 AATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES 180
AATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES
Sbjct: 121 AATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES 180
Query: 181 EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTS 240
EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTS
Sbjct: 181 EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTS 240
Query: 241 LDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTT 300
LDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTT
Sbjct: 241 LDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTT 300
Query: 301 IIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTN 360
IIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTN
Sbjct: 301 IIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTN 360
Query: 361 EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPN 420
EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPN
Sbjct: 361 EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPN 420
Query: 421 SSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480
SSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN
Sbjct: 421 SSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480
Query: 481 TQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
TQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL
Sbjct: 481 TQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 1071 bits (2770), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV
Sbjct: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
Query: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK
Sbjct: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
Query: 121 AATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES 180
AATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES
Sbjct: 121 AATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES 180
Query: 181 EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTS 240
EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTS
Sbjct: 181 EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTS 240
Query: 241 LDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTT 300
LDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTT
Sbjct: 241 LDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTT 300
Query: 301 IIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTN 360
IIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTN
Sbjct: 301 IIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTN 360
Query: 361 EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPN 420
EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPN
Sbjct: 361 EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPN 420
Query: 421 SSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480
SSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN
Sbjct: 421 SSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480
Query: 481 TQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
TQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL
Sbjct: 481 TQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 985 bits (2546), Expect = 0.0
Identities = 477/524 (91%), Positives = 499/524 (95%), Gaps = 2/524 (0%)
Query: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPP+ALISILQKGLQYV
Sbjct: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 60
Query: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
EAEISIN+DGTVFD RPIESLSLI AV+PDVVQ RQQAF EKL QQQASAAA A+A A
Sbjct: 61 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 120
Query: 121 A--ATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGH 178
A AT T A +S QNP KNREATVNGEEN AH +NNH+KPMEIDG+VEIP +KATVLRGH
Sbjct: 121 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 180
Query: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 181 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 240
Query: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDK 298
TSLDWN++GTLLA GSYDGFARIWTE+GNLASTLGQHKGPIFALKWN+KGNY+LSAGVDK
Sbjct: 241 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 300
Query: 299 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358
TTIIWDAHTGEAKQQFPFHSAPALDVDWQNN TFASCSTDMCIHVCRLGCD PVKTFQGH
Sbjct: 301 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 360
Query: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ+ C+HDLQAH+KEIYTIKWSPTGPATSN
Sbjct: 361 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 420
Query: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478
PNS+IMLASASFDSTVRLWD+E+GVCTHTL KHQEPVYSVAFSPDGKYLASGSFDK VHI
Sbjct: 421 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 480
Query: 479 WNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
WNTQSG+LVHSY+GTGGIFEVCWNARGDKVGASASDGSVCVLDL
Sbjct: 481 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 524
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 985 bits (2546), Expect = 0.0
Identities = 477/524 (91%), Positives = 499/524 (95%), Gaps = 2/524 (0%)
Query: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPP+ALISILQKGLQYV
Sbjct: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 60
Query: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
EAEISIN+DGTVFD RPIESLSLI AV+PDVVQ RQQAF EKL QQQASAAA A+A A
Sbjct: 61 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 120
Query: 121 A--ATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGH 178
A AT T A +S QNP KNREATVNGEEN AH +NNH+KPMEIDG+VEIP +KATVLRGH
Sbjct: 121 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 180
Query: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 181 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 240
Query: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDK 298
TSLDWN++GTLLA GSYDGFARIWTE+GNLASTLGQHKGPIFALKWN+KGNY+LSAGVDK
Sbjct: 241 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 300
Query: 299 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358
TTIIWDAHTGEAKQQFPFHSAPALDVDWQNN TFASCSTDMCIHVCRLGCD PVKTFQGH
Sbjct: 301 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 360
Query: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ+ C+HDLQAH+KEIYTIKWSPTGPATSN
Sbjct: 361 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 420
Query: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478
PNS+IMLASASFDSTVRLWD+E+GVCTHTL KHQEPVYSVAFSPDGKYLASGSFDK VHI
Sbjct: 421 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 480
Query: 479 WNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
WNTQSG+LVHSY+GTGGIFEVCWNARGDKVGASASDGSVCVLDL
Sbjct: 481 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 524
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 985 bits (2546), Expect = 0.0
Identities = 477/524 (91%), Positives = 499/524 (95%), Gaps = 2/524 (0%)
Query: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPP+ALISILQKGLQYV
Sbjct: 52 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
Query: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
EAEISIN+DGTVFD RPIESLSLI AV+PDVVQ RQQAF EKL QQQASAAA A+A A
Sbjct: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
Query: 121 A--ATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGH 178
A AT T A +S QNP KNREATVNGEEN AH +NNH+KPMEIDG+VEIP +KATVLRGH
Sbjct: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 231
Query: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
Query: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDK 298
TSLDWN++GTLLA GSYDGFARIWTE+GNLASTLGQHKGPIFALKWN+KGNY+LSAGVDK
Sbjct: 292 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
Query: 299 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358
TTIIWDAHTGEAKQQFPFHSAPALDVDWQNN TFASCSTDMCIHVCRLGCD PVKTFQGH
Sbjct: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
Query: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ+ C+HDLQAH+KEIYTIKWSPTGPATSN
Sbjct: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
Query: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478
PNS+IMLASASFDSTVRLWD+E+GVCTHTL KHQEPVYSVAFSPDGKYLASGSFDK VHI
Sbjct: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
Query: 479 WNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
WNTQSG+LVHSY+GTGGIFEVCWNARGDKVGASASDGSVCVLDL
Sbjct: 532 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 575
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 985 bits (2546), Expect = 0.0
Identities = 477/524 (91%), Positives = 499/524 (95%), Gaps = 2/524 (0%)
Query: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPP+ALISILQKGLQYV
Sbjct: 52 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
Query: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
EAEISIN+DGTVFD RPIESLSLI AV+PDVVQ RQQAF EKL QQQASAAA A+A A
Sbjct: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
Query: 121 A--ATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGH 178
A AT T A +S QNP KNREATVNGEEN AH +NNH+KPMEIDG+VEIP +KATVLRGH
Sbjct: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 231
Query: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
Query: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDK 298
TSLDWN++GTLLA GSYDGFARIWTE+GNLASTLGQHKGPIFALKWN+KGNY+LSAGVDK
Sbjct: 292 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
Query: 299 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358
TTIIWDAHTGEAKQQFPFHSAPALDVDWQNN TFASCSTDMCIHVCRLGCD PVKTFQGH
Sbjct: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
Query: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ+ C+HDLQAH+KEIYTIKWSPTGPATSN
Sbjct: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
Query: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478
PNS+IMLASASFDSTVRLWD+E+GVCTHTL KHQEPVYSVAFSPDGKYLASGSFDK VHI
Sbjct: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
Query: 479 WNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
WNTQSG+LVHSY+GTGGIFEVCWNARGDKVGASASDGSVCVLDL
Sbjct: 532 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 575
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 916 bits (2368), Expect = 0.0
Identities = 444/523 (84%), Positives = 478/523 (91%), Gaps = 12/523 (2%)
Query: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
MSI+SDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNING LVPP+ALISI+QKGLQYV
Sbjct: 1 MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV 60
Query: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
EAE+SIN+DGT+FD RPIESLSLI AV+PDVVQ RQQA+ +KL QQQA+AAA A
Sbjct: 61 EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAA----- 115
Query: 121 AATMTPAAISQQNPPKNREATVNGEENGAHEI-NNHSKPMEIDGDVEIPPNKATVLRGHE 179
AA SQQ KN E T NGEENGAH I NNH+ ME+DGDVEIPPNKA VLRGHE
Sbjct: 116 ------AAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHE 169
Query: 180 SEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVT 239
SEVFICAWNPVSDLLASGSGDSTARIWNL+ENS GSTQLVLRHCIREGG DVPSNKDVT
Sbjct: 170 SEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVT 229
Query: 240 SLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKT 299
SLDWNS+GTLLA GSYDGFARIWT++GNLASTLGQHKGPIFALKWNKKGN++LSAGVDKT
Sbjct: 230 SLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKT 289
Query: 300 TIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHT 359
TIIWDAHTGEAKQQFPFHSAPALDVDWQ+N TFASCSTDMCIHVC+LG D P+KTFQGHT
Sbjct: 290 TIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHT 349
Query: 360 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNP 419
NEVNAIKWDP+G LLASCSDDMTLKIWSMKQD CVHDLQAH+KEIYTIKWSPTGP T+NP
Sbjct: 350 NEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNP 409
Query: 420 NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479
N+++MLASASFDSTVRLWDV++G+C HTL KHQEPVYSVAFSPDG+YLASGSFDK VHIW
Sbjct: 410 NANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIW 469
Query: 480 NTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
NTQ+G+LVHSY+GTGGIFEVCWNA GDKVGASASDGSVCVLDL
Sbjct: 470 NTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDL 512
>gi|239748962 PREDICTED: hypothetical protein XP_002346868 [Homo
sapiens]
Length = 155
Score = 187 bits (476), Expect = 2e-47
Identities = 101/152 (66%), Positives = 116/152 (76%), Gaps = 9/152 (5%)
Query: 22 SHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESL 81
SHSAFTFGIES ISQSNING LVPP+ALISI+QKGLQYVEAE+SIN+DGT FD RP+ SL
Sbjct: 9 SHSAFTFGIESRISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTFFDGRPM-SL 67
Query: 82 SLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREAT 141
SLI A++PDVVQ RQQA+ +KL QQQA+AA AK ++ KN E T
Sbjct: 68 SLIDALMPDVVQTRQQAYSDKLKQQQAAAATANQQGSAKKK-------KKKKKKKNAENT 120
Query: 142 VNGEENGAHEI-NNHSKPMEIDGDVEIPPNKA 172
NGEENGAH I NNH+ ME+DGD+EIPPNKA
Sbjct: 121 ANGEENGAHIIANNHTDTMEVDGDIEIPPNKA 152
>gi|239742982 PREDICTED: hypothetical protein XP_002342710 [Homo
sapiens]
Length = 177
Score = 187 bits (476), Expect = 2e-47
Identities = 101/152 (66%), Positives = 116/152 (76%), Gaps = 9/152 (5%)
Query: 22 SHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESL 81
SHSAFTFGIES ISQSNING LVPP+ALISI+QKGLQYVEAE+SIN+DGT FD RP+ SL
Sbjct: 31 SHSAFTFGIESRISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTFFDGRPM-SL 89
Query: 82 SLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREAT 141
SLI A++PDVVQ RQQA+ +KL QQQA+AA AK ++ KN E T
Sbjct: 90 SLIDALMPDVVQTRQQAYSDKLKQQQAAAATANQQGSAKKK-------KKKKKKKNAENT 142
Query: 142 VNGEENGAHEI-NNHSKPMEIDGDVEIPPNKA 172
NGEENGAH I NNH+ ME+DGD+EIPPNKA
Sbjct: 143 ANGEENGAHIIANNHTDTMEVDGDIEIPPNKA 174
>gi|239754401 PREDICTED: similar to transducin (beta)-like 1
X-linked receptor 1 [Homo sapiens]
Length = 132
Score = 140 bits (352), Expect = 4e-33
Identities = 73/99 (73%), Positives = 83/99 (83%), Gaps = 1/99 (1%)
Query: 22 SHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESL 81
SHSAFTFGIES ISQSNING LVPP+ALISI+QKGLQYVEAE+SIN+DGT FD RP+ SL
Sbjct: 9 SHSAFTFGIESRISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTFFDGRPM-SL 67
Query: 82 SLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
SLI A++PDVVQ RQQA+ +KL QQQA+AA AK
Sbjct: 68 SLIDALMPDVVQTRQQAYSDKLKQQQAAAATANQQGSAK 106
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 136 bits (342), Expect = 5e-32
Identities = 91/309 (29%), Positives = 141/309 (45%), Gaps = 28/309 (9%)
Query: 175 LRGHESEVFICAWN-PVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233
L GH + V+ A+N P D +A+GS D T ++W++ H R GH
Sbjct: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK--------CYHTFR--GHTA- 178
Query: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVL 292
++ L +N TL+A GS D A++W +NG TL H I +L +N G+ ++
Sbjct: 179 ---EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII 235
Query: 293 SAGVDKTTIIWDAHTGEAKQQFPFHSAP--ALDVDWQNNMTFASCSTDMCIHVCRLGCDH 350
+ D T ++WDA TG H A + +W ++ S D +
Sbjct: 236 TGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTG-SMDKTCKLWDATNGK 294
Query: 351 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWS 410
V T GH +E+ +D +G L+A+ S D T +I+S C+ L+ H EI I ++
Sbjct: 295 CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN 354
Query: 411 PTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASG 470
P G L + S D T R+WD + G C L H + ++S AF+ G + +G
Sbjct: 355 PQGNH---------LLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405
Query: 471 SFDKYVHIW 479
S D IW
Sbjct: 406 SKDNTCRIW 414
Score = 102 bits (255), Expect = 7e-22
Identities = 65/252 (25%), Positives = 118/252 (46%), Gaps = 12/252 (4%)
Query: 268 LASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 327
L L H P+ + NK G+ ++ D+T +WD +GE H + +
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
Query: 328 N--NMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 385
N A+ S D + + TF+GHT E+ + ++P L+A+ S D T K+
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
Query: 386 WSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCT 445
W ++ V+ L+ HS EI ++ ++ +G + + SFD TV +WD + G
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGD---------RIITGSFDHTVVVWDADTGRKV 254
Query: 446 HTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNAR 504
+ L+ H + S +F+ D + +GS DK +W+ +G V + G I + C++
Sbjct: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314
Query: 505 GDKVGASASDGS 516
G + +++DG+
Sbjct: 315 GKLIATASADGT 326
Score = 86.7 bits (213), Expect = 5e-17
Identities = 49/170 (28%), Positives = 82/170 (48%), Gaps = 9/170 (5%)
Query: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
K + H + + + SG + S D T K+W ++ L+ H +Y I
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI----- 140
Query: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSF 472
A +NP +A+ SFD T +LW VE G C HT H + ++F+P +A+GS
Sbjct: 141 --AFNNPYGD-KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197
Query: 473 DKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCVLD 521
D +W+ Q+G V++ +G + I + +N GD++ + D +V V D
Sbjct: 198 DTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Score = 68.9 bits (167), Expect = 1e-11
Identities = 55/217 (25%), Positives = 94/217 (43%), Gaps = 56/217 (25%)
Query: 171 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 230
K +L GH +E+ ++N L+ +GS D T ++W + +NG + GH
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW---DATNGKCVATLT-------GH 302
Query: 231 DVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGN 289
D ++ ++ G L+A S DG ARI++ + L H+G I + +N +GN
Sbjct: 303 D----DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358
Query: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
++L+ DKT IWDA TG+ C+ V
Sbjct: 359 HLLTGSSDKTARIWDAQTGQ------------------------------CLQV------ 382
Query: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386
+GHT+E+ + ++ G ++ + S D T +IW
Sbjct: 383 -----LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 125 bits (314), Expect = 9e-29
Identities = 82/283 (28%), Positives = 133/283 (46%), Gaps = 12/283 (4%)
Query: 238 VTSLDWNSDGTLLAMGSYDGFARIWTENGNL-ASTLGQHKGPIFALKWNKKGNYVLSAGV 296
+TSLD + +G LA S+D F +W + A HK + +++++ GN + SA
Sbjct: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
Query: 297 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF-ASCSTDMCIHVCRLGCDHPVKTF 355
D+T +W +F H+AP VD+ + F A+ S D I V + + +
Sbjct: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
Query: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 415
HT+ V K+ P G L+ SCS+D T+KIW CV++ + ++P+G
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
Query: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKY 475
+ASA D TV++WDV H V ++F P G YL + S D
Sbjct: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
Query: 476 VHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSV 517
+ I + G L+++ QG TG +F V ++ G+ + +D V
Sbjct: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
Score = 113 bits (282), Expect = 5e-25
Identities = 81/314 (25%), Positives = 136/314 (43%), Gaps = 27/314 (8%)
Query: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
+GH++ + +P LA+ S D+ +WN ++ R GH
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
Query: 236 KDV-TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLS 293
KDV TS+ ++ G LLA S D R+W + S H P+ ++ ++ G ++ +
Sbjct: 60 KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
Query: 294 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPV 352
A DK+ +W + H+ + + SCS D I + V
Sbjct: 120 ASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV 179
Query: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
F N + ++PSG +AS D T+K+W ++ + + Q HS + I + P+
Sbjct: 180 NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS 239
Query: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSF 472
G L +AS D T+++ D+ +G +TL H PV++V+FS G+ ASG
Sbjct: 240 GN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA 290
Query: 473 DKYVHIWNTQSGSL 486
D V +W T L
Sbjct: 291 DTQVLLWRTNFDEL 304
Score = 85.9 bits (211), Expect = 8e-17
Identities = 56/214 (26%), Positives = 104/214 (48%), Gaps = 11/214 (5%)
Query: 311 KQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP 369
++ F H A +D N A+ S D + + + GH + V ++++ P
Sbjct: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
Query: 370 SGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASAS 429
G LLAS S D T+++W + + +AH+ + ++ +S G LA+AS
Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
Query: 430 FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489
D ++++W + + ++L +H V FSPDG+ + S S DK + IW+T + V++
Sbjct: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
Query: 490 YQGTGGIFE-VCWNARGDKVGASASDGSVCVLDL 522
+ + G V +N G + ++ SD +V V D+
Sbjct: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215
Score = 30.0 bits (66), Expect = 5.4
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 209
L+GH VF +++ +L ASG D+ +W N
Sbjct: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 125 bits (313), Expect = 1e-28
Identities = 109/391 (27%), Positives = 156/391 (39%), Gaps = 74/391 (18%)
Query: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
L GH V A++P LASGSGD+T R W+L ST+ C GH
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL-------STETPHFTC---KGH---- 155
Query: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFALKW-----NKK 287
V S+ W+ DG LA G +G +W + + TL H I L W N +
Sbjct: 156 RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215
Query: 288 GNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLG 347
YV S+ D + IWD G ++ H+ + W + S S D I V R
Sbjct: 216 CRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAH 275
Query: 348 CDHPVKTFQGHTNEVNAI---------------------KWDPSGML------------- 373
+T QGH + VN + D G L
Sbjct: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNL 335
Query: 374 --------LASCSDDMTLKIWSMKQD-ACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIM 424
L S SDD TL +WS +D + + H I + +SP S +
Sbjct: 336 VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP---------DSRI 386
Query: 425 LASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSG 484
+ASASFD +++LWD G +L H VY +A+S D + L SGS D + +W+ ++
Sbjct: 387 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446
Query: 485 SLVHSYQG-TGGIFEVCWNARGDKVGASASD 514
L G ++ V W+ G +V + D
Sbjct: 447 KLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477
Score = 73.2 bits (178), Expect = 6e-13
Identities = 59/226 (26%), Positives = 86/226 (38%), Gaps = 47/226 (20%)
Query: 270 STLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN 329
S+L H + ++ ++ G Y+ S D T WD
Sbjct: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD------------------------- 142
Query: 330 MTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 389
L + P T +GH + V +I W P G LAS + + +W
Sbjct: 143 ----------------LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPS 186
Query: 390 QDACV-HDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTL 448
V L HSK I + W P +NP +AS+S D +VR+WD G C L
Sbjct: 187 TGKQVGRTLAGHSKWITGLSWE---PLHANPECR-YVASSSKDGSVRIWDTTAGRCERIL 242
Query: 449 MKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTG 494
H + V + + DG L S S D+ + +W G L + QG G
Sbjct: 243 TGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
Score = 73.2 bits (178), Expect = 6e-13
Identities = 79/313 (25%), Positives = 113/313 (36%), Gaps = 74/313 (23%)
Query: 175 LRGHESEVFICAW-----NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229
L GH + +W NP +AS S D + RIW+ + G + +L G
Sbjct: 195 LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD----TTAGRCERILT------G 244
Query: 230 HDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQH------------- 275
H + VT L W DG LL S D ++W +G L TL H
Sbjct: 245 H----TQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299
Query: 276 -------------------KGPIFALKWNKKGNY----------VLSAGVDKTTIIWD-A 305
+G + LK Y ++S D T +W A
Sbjct: 300 ALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPA 359
Query: 306 HTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNA 364
+ + H A V + ++ AS S D I + + + +GH V
Sbjct: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
Query: 365 IKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIM 424
I W LL S S D TLK+W +K DL H+ E+Y + WSP G
Sbjct: 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ---------R 470
Query: 425 LASASFDSTVRLW 437
+AS D +R+W
Sbjct: 471 VASGGKDKCLRIW 483
Score = 67.4 bits (163), Expect = 3e-11
Identities = 46/136 (33%), Positives = 69/136 (50%), Gaps = 16/136 (11%)
Query: 393 CVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQ 452
C L+ HS+ + ++ +SPTG LAS S D+TVR WD+ T H+
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGK---------YLASGSGDTTVRFWDLSTETPHFTCKGHR 156
Query: 453 EPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLV------HSYQGTGGIFE-VCWNARG 505
V S+++SPDG+ LASG + + +W+ +G V HS TG +E + N
Sbjct: 157 HWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
Query: 506 DKVGASASDGSVCVLD 521
V +S+ DGSV + D
Sbjct: 217 RYVASSSKDGSVRIWD 232
>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
Length = 1298
Score = 124 bits (310), Expect = 3e-28
Identities = 103/376 (27%), Positives = 162/376 (43%), Gaps = 49/376 (13%)
Query: 130 SQQNPPKNREATVNGE--------ENGAHEIN-NHSKPMEIDGDV---EIPPNKATVLR- 176
S Q+P KN + E +N A + H+ +DG V ++ K LR
Sbjct: 306 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 365
Query: 177 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
GH +F C + P +LLA+ S D T ++W++N + + P
Sbjct: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLT---------------AVYTSPG 410
Query: 235 NKDVT-SLDWNSDG-TLLAMGSYDGFARIWT-ENGNLASTLGQH-KGPIFALKWNKKGNY 290
N+ V SL W G +A G+ A IW + G + +H IF + W+ K +
Sbjct: 411 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 470
Query: 291 VLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN---MTFASCS-TDMCIHVCRL 346
++ I G+ ++ H A DW N M C T++ ++
Sbjct: 471 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 529
Query: 347 GCDHPVKTFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQDACVHDLQAHSKEIY 405
D P+K F GHT +V +KW P +L S SDD T++IW QDAC++ L H+ +
Sbjct: 530 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 589
Query: 406 TIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGK 465
+ W N +L S S+D T+++WD +G C T+ H VY + P
Sbjct: 590 GLMW--------NTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 641
Query: 466 Y-LASGSFDKYVHIWN 480
+ +AS S D V +W+
Sbjct: 642 FTMASCSRDSTVRLWS 657
Score = 90.9 bits (224), Expect = 3e-18
Identities = 69/266 (25%), Positives = 121/266 (45%), Gaps = 35/266 (13%)
Query: 246 DGTLLAMGSYDGFARIWTENGNLAS-TLGQHKGPIFALKWNKKGNYVLSAGVDKT-TIIW 303
D LLA S+DG ++W N A T ++G I++L W G ++ G + IW
Sbjct: 381 DPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIW 440
Query: 304 DAHTGEAKQQFPFHSAPALD-VDW--QNNMTFASCSTD-MCIHVCRLGCDHPVKTFQG-- 357
+ G+ Q+F H + + W +++ A+CS+D CI ++T G
Sbjct: 441 NVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI----------IRTIDGKV 490
Query: 358 -----HTNEVNAIKWDPSGM-LLASCSDDMTLKIW--SMKQDACVHDLQAHSKEIYTIKW 409
H V W + ++A+ +D ++++ + D + H+ +++ +KW
Sbjct: 491 LHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKW 550
Query: 410 SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLA- 468
SP +L S S D TVR+WD Q C + L H PV + ++ + YL
Sbjct: 551 SPLREG--------ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLI 602
Query: 469 SGSFDKYVHIWNTQSGSLVHSYQGTG 494
SGS+D + +W+T+ G+ V + G
Sbjct: 603 SGSWDYTIKVWDTREGTCVDTVYDHG 628
Score = 72.4 bits (176), Expect = 9e-13
Identities = 41/144 (28%), Positives = 70/144 (48%), Gaps = 17/144 (11%)
Query: 380 DMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDV 439
DM K W +D H + I+ K+ P P +LA+ASFD T+++WD+
Sbjct: 354 DMGAKKWDFLRDL------GHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 399
Query: 440 EQGVCTHTLMKHQEPVYSVAFSPDG-KYLASGSFDKYVHIWNTQSGSLVHSY--QGTGGI 496
+T ++ +YS++++P G +A G+ IWN Q G ++ + GT GI
Sbjct: 400 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 459
Query: 497 FEVCWNARGDKVGASASDGSVCVL 520
F + W+ + K A+ S C++
Sbjct: 460 FCIAWSHKDSKRIATCSSDGFCII 483
Score = 52.4 bits (124), Expect = 1e-06
Identities = 90/398 (22%), Positives = 155/398 (38%), Gaps = 93/398 (23%)
Query: 174 VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
++ H+ + +W P + DL ASGS D+ IWN+ E Q V+ G +
Sbjct: 54 IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE-------QKVIAKLDSTKG--I 104
Query: 233 PSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHK------GPIFALKW-- 284
P++ S WN++ ++A S+ G IWT +G + + HK I +W
Sbjct: 105 PAS---LSWCWNAE-DVVAFVSHRGPLFIWTISGPDSGVI-VHKDAHSFLSDICMFRWHT 159
Query: 285 NKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMT---FASCSTDMCI 341
++KG V+ +D + I+ H G Q+ D ++ +T + STD +
Sbjct: 160 HQKGK-VVFGHIDGSLSIF--HPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLL 216
Query: 342 HVC-----------RLGCDHPVKTFQ--GHTNEVNAIKWDPS--GMLLASCSDDMTLKIW 386
V L C + TF V + W PS GM + S L+IW
Sbjct: 217 VVNLHYGIRLVDSESLSC---ITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIW 273
Query: 387 SMKQDA-------------CVHDLQAHSKEIYTIKWSPT------------GPATSNPNS 421
++ + C+H L + ++ ++++ SPT P T N
Sbjct: 274 NVSRTTPIDNLKLKKTGFHCLHVLNSPPRKKFSVQ-SPTKNHYTSSTSEAVPPPTLTQNQ 332
Query: 422 SIMLASAS------------FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDG-KYLA 468
+ L +D + WD + + H E ++ F PD LA
Sbjct: 333 AFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD------LGHVETIFDCKFKPDDPNLLA 386
Query: 469 SGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARG 505
+ SFD + +W+ + + V++ G G I+ + W G
Sbjct: 387 TASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGG 424
>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
Length = 1322
Score = 124 bits (310), Expect = 3e-28
Identities = 103/376 (27%), Positives = 162/376 (43%), Gaps = 49/376 (13%)
Query: 130 SQQNPPKNREATVNGE--------ENGAHEIN-NHSKPMEIDGDV---EIPPNKATVLR- 176
S Q+P KN + E +N A + H+ +DG V ++ K LR
Sbjct: 330 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 389
Query: 177 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
GH +F C + P +LLA+ S D T ++W++N + + P
Sbjct: 390 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLT---------------AVYTSPG 434
Query: 235 NKDVT-SLDWNSDG-TLLAMGSYDGFARIWT-ENGNLASTLGQH-KGPIFALKWNKKGNY 290
N+ V SL W G +A G+ A IW + G + +H IF + W+ K +
Sbjct: 435 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 494
Query: 291 VLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN---MTFASCS-TDMCIHVCRL 346
++ I G+ ++ H A DW N M C T++ ++
Sbjct: 495 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 553
Query: 347 GCDHPVKTFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQDACVHDLQAHSKEIY 405
D P+K F GHT +V +KW P +L S SDD T++IW QDAC++ L H+ +
Sbjct: 554 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 613
Query: 406 TIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGK 465
+ W N +L S S+D T+++WD +G C T+ H VY + P
Sbjct: 614 GLMW--------NTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 665
Query: 466 Y-LASGSFDKYVHIWN 480
+ +AS S D V +W+
Sbjct: 666 FTMASCSRDSTVRLWS 681
Score = 90.9 bits (224), Expect = 3e-18
Identities = 69/266 (25%), Positives = 121/266 (45%), Gaps = 35/266 (13%)
Query: 246 DGTLLAMGSYDGFARIWTENGNLAS-TLGQHKGPIFALKWNKKGNYVLSAGVDKT-TIIW 303
D LLA S+DG ++W N A T ++G I++L W G ++ G + IW
Sbjct: 405 DPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIW 464
Query: 304 DAHTGEAKQQFPFHSAPALD-VDW--QNNMTFASCSTD-MCIHVCRLGCDHPVKTFQG-- 357
+ G+ Q+F H + + W +++ A+CS+D CI ++T G
Sbjct: 465 NVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI----------IRTIDGKV 514
Query: 358 -----HTNEVNAIKWDPSGM-LLASCSDDMTLKIW--SMKQDACVHDLQAHSKEIYTIKW 409
H V W + ++A+ +D ++++ + D + H+ +++ +KW
Sbjct: 515 LHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKW 574
Query: 410 SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLA- 468
SP +L S S D TVR+WD Q C + L H PV + ++ + YL
Sbjct: 575 SPLREG--------ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLI 626
Query: 469 SGSFDKYVHIWNTQSGSLVHSYQGTG 494
SGS+D + +W+T+ G+ V + G
Sbjct: 627 SGSWDYTIKVWDTREGTCVDTVYDHG 652
Score = 72.4 bits (176), Expect = 9e-13
Identities = 41/144 (28%), Positives = 70/144 (48%), Gaps = 17/144 (11%)
Query: 380 DMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDV 439
DM K W +D H + I+ K+ P P +LA+ASFD T+++WD+
Sbjct: 378 DMGAKKWDFLRDL------GHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 423
Query: 440 EQGVCTHTLMKHQEPVYSVAFSPDG-KYLASGSFDKYVHIWNTQSGSLVHSY--QGTGGI 496
+T ++ +YS++++P G +A G+ IWN Q G ++ + GT GI
Sbjct: 424 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 483
Query: 497 FEVCWNARGDKVGASASDGSVCVL 520
F + W+ + K A+ S C++
Sbjct: 484 FCIAWSHKDSKRIATCSSDGFCII 507
Score = 52.4 bits (124), Expect = 1e-06
Identities = 90/398 (22%), Positives = 155/398 (38%), Gaps = 93/398 (23%)
Query: 174 VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
++ H+ + +W P + DL ASGS D+ IWN+ E Q V+ G +
Sbjct: 78 IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE-------QKVIAKLDSTKG--I 128
Query: 233 PSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHK------GPIFALKW-- 284
P++ S WN++ ++A S+ G IWT +G + + HK I +W
Sbjct: 129 PAS---LSWCWNAE-DVVAFVSHRGPLFIWTISGPDSGVI-VHKDAHSFLSDICMFRWHT 183
Query: 285 NKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMT---FASCSTDMCI 341
++KG V+ +D + I+ H G Q+ D ++ +T + STD +
Sbjct: 184 HQKGK-VVFGHIDGSLSIF--HPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLL 240
Query: 342 HVC-----------RLGCDHPVKTFQ--GHTNEVNAIKWDPS--GMLLASCSDDMTLKIW 386
V L C + TF V + W PS GM + S L+IW
Sbjct: 241 VVNLHYGIRLVDSESLSC---ITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIW 297
Query: 387 SMKQDA-------------CVHDLQAHSKEIYTIKWSPT------------GPATSNPNS 421
++ + C+H L + ++ ++++ SPT P T N
Sbjct: 298 NVSRTTPIDNLKLKKTGFHCLHVLNSPPRKKFSVQ-SPTKNHYTSSTSEAVPPPTLTQNQ 356
Query: 422 SIMLASAS------------FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDG-KYLA 468
+ L +D + WD + + H E ++ F PD LA
Sbjct: 357 AFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD------LGHVETIFDCKFKPDDPNLLA 410
Query: 469 SGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARG 505
+ SFD + +W+ + + V++ G G I+ + W G
Sbjct: 411 TASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGG 448
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 122 bits (305), Expect = 1e-27
Identities = 87/259 (33%), Positives = 122/259 (47%), Gaps = 59/259 (22%)
Query: 232 VPSNKDVTS--LDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQ-HKGPIFALKWN 285
VP++ D L WN GTLLA D RIW G+ S L + H+ + + W+
Sbjct: 11 VPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS 70
Query: 286 KKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCR 345
GNY+ SA D TT IW K Q F
Sbjct: 71 PCGNYLASASFDATTCIWK------KNQDDFEC--------------------------- 97
Query: 346 LGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD---ACVHDLQAHSK 402
V T +GH NEV ++ W PSG LLA+CS D ++ +W + ++ CV L +H++
Sbjct: 98 ------VTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQ 151
Query: 403 EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAF 460
++ + W P S +LASAS+D TV+L+ E+ VC TL H+ V+S+AF
Sbjct: 152 DVKHVVWHP---------SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202
Query: 461 SPDGKYLASGSFDKYVHIW 479
P G+ LAS S D+ V IW
Sbjct: 203 DPSGQRLASCSDDRTVRIW 221
Score = 105 bits (262), Expect = 1e-22
Identities = 96/339 (28%), Positives = 141/339 (41%), Gaps = 55/339 (16%)
Query: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
+S + AWNP LLAS GD RIW +S + + + EG + V
Sbjct: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDS------WICKSVLSEG-----HQRTV 64
Query: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKGPIFALKWNKKGNYVLSAG 295
+ W+ G LA S+D IW +N + +TL H+ + ++ W GN + +
Sbjct: 65 RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124
Query: 296 VDKTTIIWDAHTG---EAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHP 351
DK+ +W+ E H+ V W + AS S D + + R D
Sbjct: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDW 184
Query: 352 V--KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW---------------SMKQDACV 394
V T +GH + V ++ +DPSG LASCSDD T++IW S C+
Sbjct: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244
Query: 395 HDLQA-HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLW------DVEQ---GVC 444
L HS+ IY I W A LA+A D +R++ D +Q +
Sbjct: 245 CTLSGFHSRTIYDIAWCQLTGA---------LATACGDDAIRVFQEDPNSDPQQPTFSLT 295
Query: 445 THTLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQ 482
H H + V VA++P + LAS S D V W Q
Sbjct: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
Score = 84.3 bits (207), Expect = 2e-16
Identities = 67/248 (27%), Positives = 104/248 (41%), Gaps = 41/248 (16%)
Query: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
T L GHE+EV AW P +LLA+ S D + +W ++E ++ H
Sbjct: 99 TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH--------- 149
Query: 233 PSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKGPIFALKWNKKGN 289
+DV + W+ LLA SYD +++ E + +TL H+ +++L ++ G
Sbjct: 150 --TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQ 207
Query: 290 YVLSAGVDKTTIIWDAHTGEAKQQFP----------------FHSAPALDVDW-QNNMTF 332
+ S D+T IW + +Q FHS D+ W Q
Sbjct: 208 RLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGAL 267
Query: 333 ASCSTDMCIHVCR--LGCDHPVKTF-------QGHTNEVNAIKWDPSGM-LLASCSDDMT 382
A+ D I V + D TF Q H+ +VN + W+P LLASCSDD
Sbjct: 268 ATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGE 327
Query: 383 LKIWSMKQ 390
+ W ++
Sbjct: 328 VAFWKYQR 335
Score = 79.0 bits (193), Expect = 1e-14
Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 21/172 (12%)
Query: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD--ACVHDLQAHSKEIYTIKWSPTG 413
+GH V + W P G LAS S D T IW QD CV L+ H E+ ++ W+P+G
Sbjct: 58 EGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSG 117
Query: 414 PATSNPNSSIMLASASFDSTVRLWDVEQG---VCTHTLMKHQEPVYSVAFSPDGKYLASG 470
+LA+ S D +V +W+V++ C L H + V V + P + LAS
Sbjct: 118 N---------LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASA 168
Query: 471 SFDKYVHIWNTQSGSLV-----HSYQGTGGIFEVCWNARGDKVGASASDGSV 517
S+D V ++ + V ++ T ++ + ++ G ++ + + D +V
Sbjct: 169 SYDDTVKLYREEEDDWVCCATLEGHEST--VWSLAFDPSGQRLASCSDDRTV 218
Score = 34.3 bits (77), Expect = 0.28
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 8/68 (11%)
Query: 458 VAFSPDGKYLASGSFDKYVHIWNTQSGS------LVHSYQGTGGIFEVCWNARGDKVGAS 511
+A++P G LAS D+ + IW T+ S L +Q T + +V W+ G+ + ++
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT--VRKVAWSPCGNYLASA 79
Query: 512 ASDGSVCV 519
+ D + C+
Sbjct: 80 SFDATTCI 87
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 121 bits (303), Expect = 2e-27
Identities = 72/247 (29%), Positives = 123/247 (49%), Gaps = 13/247 (5%)
Query: 250 LAMGSYDGFARIWTENGNLA--STLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHT 307
LA+ S ++ EN N A TL H + ++K++ G ++ S+ D+ IIW A+
Sbjct: 13 LALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYD 72
Query: 308 GEAKQQFPFHSAPALDVDWQNNMT-FASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIK 366
G+ ++ H+ DV W ++ + S S D + + + +KT +GH+N V
Sbjct: 73 GKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN 132
Query: 367 WDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLA 426
++P L+ S S D T+KIW +K C+ L AHS + + ++ +G ++
Sbjct: 133 FNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS---------LIV 183
Query: 427 SASFDSTVRLWDVEQGVCTHTLMKHQEPVYS-VAFSPDGKYLASGSFDKYVHIWNTQSGS 485
S S+D R+WD G C TL+ P S V FSP+GKY+ + + D + +W+ G
Sbjct: 184 SGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGR 243
Query: 486 LVHSYQG 492
+ +Y G
Sbjct: 244 CLKTYTG 250
Score = 104 bits (259), Expect = 2e-22
Identities = 84/325 (25%), Positives = 134/325 (41%), Gaps = 33/325 (10%)
Query: 166 EIPPNKATVLR----GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVL 221
E+P N L+ GH V ++P + LAS S D IW + G + L
Sbjct: 24 EVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYD----GKYEKTL 79
Query: 222 RHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIF 280
GH N +++ + W+SD + L S D ++W +G TL H +F
Sbjct: 80 Y------GH----NLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVF 129
Query: 281 ALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDM 339
+N N ++S D+T IW+ TG+ + HS P V + + S S D
Sbjct: 130 CCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDG 189
Query: 340 CIHVCRLGCDHPVKTFQGHTN-EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQ 398
+ +KT N V+ +K+ P+G + + + D TLK+W + C+
Sbjct: 190 LCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT 249
Query: 399 AHSKEIYTI--KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
H E Y I +S TG + S S D+ V +W+++ L H + V
Sbjct: 250 GHKNEKYCIFANFSVTG--------GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 301
Query: 457 SVAFSPDGKYLASGSF--DKYVHIW 479
S A P +AS + DK + +W
Sbjct: 302 SAACHPTENLIASAALENDKTIKLW 326
Score = 93.6 bits (231), Expect = 4e-19
Identities = 55/169 (32%), Positives = 81/169 (47%), Gaps = 10/169 (5%)
Query: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413
T GHT V+++K+ P+G LAS S D + IW L H+ EI + WS
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS--- 92
Query: 414 PATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473
+ S L SAS D T++LWDV G C TL H V+ F+P + SGSFD
Sbjct: 93 ------SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
Query: 474 KYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCVLD 521
+ V IW ++G + + + + V +N G + + + DG + D
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Score = 53.1 bits (126), Expect = 6e-07
Identities = 35/133 (26%), Positives = 57/133 (42%), Gaps = 9/133 (6%)
Query: 368 DPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLAS 427
D L S S + + ++ A L H++ + ++K+SP G LAS
Sbjct: 8 DAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGE---------WLAS 58
Query: 428 ASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLV 487
+S D + +W G TL H + VA+S D L S S DK + +W+ +SG +
Sbjct: 59 SSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCL 118
Query: 488 HSYQGTGGIFEVC 500
+ +G C
Sbjct: 119 KTLKGHSNYVFCC 131
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 118 bits (296), Expect = 1e-26
Identities = 65/230 (28%), Positives = 112/230 (48%), Gaps = 11/230 (4%)
Query: 265 NGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDV 324
N L TL H + ++K++ G ++ S+ DK IW A+ G+ ++ H DV
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
Query: 325 DWQNNMTF-ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383
W ++ S S D + + + +KT +GH+N V ++P L+ S S D ++
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 384 KIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGV 443
+IW +K C+ L AHS + + ++ G ++ S+S+D R+WD G
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS---------LIVSSSYDGLCRIWDTASGQ 204
Query: 444 CTHTLMKHQEPVYS-VAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG 492
C TL+ P S V FSP+GKY+ + + D + +W+ G + +Y G
Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Score = 115 bits (288), Expect = 1e-25
Identities = 76/264 (28%), Positives = 127/264 (48%), Gaps = 17/264 (6%)
Query: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSA 294
K V+S+ ++ +G LA S D +IW +G T+ HK I + W+ N ++SA
Sbjct: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105
Query: 295 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW--QNNMTFASCSTDMCIHVCRLGCDHPV 352
DKT IWD +G+ + HS ++ Q+N+ S S D + + + +
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL-IVSGSFDESVRIWDVKTGKCL 164
Query: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL-QAHSKEIYTIKWSP 411
KT H++ V+A+ ++ G L+ S S D +IW C+ L + + +K+SP
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
Query: 412 TGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFS---PDGKYLA 468
G + +A+ D+T++LWD +G C T H+ Y + + GK++
Sbjct: 225 NGK---------YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 469 SGSFDKYVHIWNTQSGSLVHSYQG 492
SGS D V+IWN Q+ +V QG
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQG 299
Score = 111 bits (277), Expect = 2e-24
Identities = 85/324 (26%), Positives = 137/324 (42%), Gaps = 31/324 (9%)
Query: 167 IPPNKAT--VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHC 224
+ PN A L GH V ++P + LAS S D +IW + G + +
Sbjct: 31 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD----GKFEKTI--- 83
Query: 225 IREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALK 283
GH + ++ + W+SD LL S D +IW +G TL H +F
Sbjct: 84 ---SGHKL----GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136
Query: 284 WNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNMTFASCSTDMCIH 342
+N + N ++S D++ IWD TG+ + P HS P V + ++ S S D
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 343 VCRLGCDHPVKTFQGHTN-EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHS 401
+ +KT N V+ +K+ P+G + + + D TLK+W + C+ H
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256
Query: 402 KEIYTI--KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVA 459
E Y I +S TG + S S D+ V +W+++ L H + V S A
Sbjct: 257 NEKYCIFANFSVTG--------GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308
Query: 460 FSPDGKYLASGSF--DKYVHIWNT 481
P +AS + DK + +W +
Sbjct: 309 CHPTENIIASAALENDKTIKLWKS 332
Score = 60.5 bits (145), Expect = 4e-09
Identities = 36/127 (28%), Positives = 62/127 (48%), Gaps = 10/127 (7%)
Query: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
L H+K + ++K+SP G LAS+S D +++W G T+ H+ +
Sbjct: 41 LAGHTKAVSSVKFSPNGE---------WLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91
Query: 457 SVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVC-WNARGDKVGASASDG 515
VA+S D L S S DK + IW+ SG + + +G C +N + + + + + D
Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151
Query: 516 SVCVLDL 522
SV + D+
Sbjct: 152 SVRIWDV 158
Score = 50.1 bits (118), Expect = 5e-06
Identities = 26/77 (33%), Positives = 44/77 (57%), Gaps = 1/77 (1%)
Query: 447 TLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTG-GIFEVCWNARG 505
TL H + V SV FSP+G++LAS S DK + IW G + G GI +V W++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 506 DKVGASASDGSVCVLDL 522
+ + +++ D ++ + D+
Sbjct: 100 NLLVSASDDKTLKIWDV 116
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 118 bits (296), Expect = 1e-26
Identities = 65/230 (28%), Positives = 112/230 (48%), Gaps = 11/230 (4%)
Query: 265 NGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDV 324
N L TL H + ++K++ G ++ S+ DK IW A+ G+ ++ H DV
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
Query: 325 DWQNNMTF-ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383
W ++ S S D + + + +KT +GH+N V ++P L+ S S D ++
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 384 KIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGV 443
+IW +K C+ L AHS + + ++ G ++ S+S+D R+WD G
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS---------LIVSSSYDGLCRIWDTASGQ 204
Query: 444 CTHTLMKHQEPVYS-VAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG 492
C TL+ P S V FSP+GKY+ + + D + +W+ G + +Y G
Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Score = 115 bits (288), Expect = 1e-25
Identities = 76/264 (28%), Positives = 127/264 (48%), Gaps = 17/264 (6%)
Query: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSA 294
K V+S+ ++ +G LA S D +IW +G T+ HK I + W+ N ++SA
Sbjct: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105
Query: 295 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW--QNNMTFASCSTDMCIHVCRLGCDHPV 352
DKT IWD +G+ + HS ++ Q+N+ S S D + + + +
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL-IVSGSFDESVRIWDVKTGKCL 164
Query: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL-QAHSKEIYTIKWSP 411
KT H++ V+A+ ++ G L+ S S D +IW C+ L + + +K+SP
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
Query: 412 TGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFS---PDGKYLA 468
G + +A+ D+T++LWD +G C T H+ Y + + GK++
Sbjct: 225 NGK---------YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 469 SGSFDKYVHIWNTQSGSLVHSYQG 492
SGS D V+IWN Q+ +V QG
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQG 299
Score = 111 bits (277), Expect = 2e-24
Identities = 85/324 (26%), Positives = 137/324 (42%), Gaps = 31/324 (9%)
Query: 167 IPPNKAT--VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHC 224
+ PN A L GH V ++P + LAS S D +IW + G + +
Sbjct: 31 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD----GKFEKTI--- 83
Query: 225 IREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALK 283
GH + ++ + W+SD LL S D +IW +G TL H +F
Sbjct: 84 ---SGHKL----GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136
Query: 284 WNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNMTFASCSTDMCIH 342
+N + N ++S D++ IWD TG+ + P HS P V + ++ S S D
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 343 VCRLGCDHPVKTFQGHTN-EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHS 401
+ +KT N V+ +K+ P+G + + + D TLK+W + C+ H
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256
Query: 402 KEIYTI--KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVA 459
E Y I +S TG + S S D+ V +W+++ L H + V S A
Sbjct: 257 NEKYCIFANFSVTG--------GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308
Query: 460 FSPDGKYLASGSF--DKYVHIWNT 481
P +AS + DK + +W +
Sbjct: 309 CHPTENIIASAALENDKTIKLWKS 332
Score = 60.5 bits (145), Expect = 4e-09
Identities = 36/127 (28%), Positives = 62/127 (48%), Gaps = 10/127 (7%)
Query: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
L H+K + ++K+SP G LAS+S D +++W G T+ H+ +
Sbjct: 41 LAGHTKAVSSVKFSPNGE---------WLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91
Query: 457 SVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVC-WNARGDKVGASASDG 515
VA+S D L S S DK + IW+ SG + + +G C +N + + + + + D
Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151
Query: 516 SVCVLDL 522
SV + D+
Sbjct: 152 SVRIWDV 158
Score = 50.1 bits (118), Expect = 5e-06
Identities = 26/77 (33%), Positives = 44/77 (57%), Gaps = 1/77 (1%)
Query: 447 TLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTG-GIFEVCWNARG 505
TL H + V SV FSP+G++LAS S DK + IW G + G GI +V W++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 506 DKVGASASDGSVCVLDL 522
+ + +++ D ++ + D+
Sbjct: 100 NLLVSASDDKTLKIWDV 116
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 117 bits (294), Expect = 2e-26
Identities = 86/325 (26%), Positives = 136/325 (41%), Gaps = 68/325 (20%)
Query: 168 PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 227
PP K L GH S V ++PV ++ S S D+T ++W+ G + L+
Sbjct: 98 PPEKYA-LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYET----GDFERTLK----- 147
Query: 228 GGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENG-NLASTLGQHKGPIFALKWNK 286
GH V + ++ G LLA S D ++W G T+ H + ++
Sbjct: 148 -GH----TDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMP 202
Query: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRL 346
G++++SA DKT +W+ TG
Sbjct: 203 NGDHIVSASRDKTIKMWEVQTG-------------------------------------- 224
Query: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
+ VKTF GH V ++ + G L+ASCS+D T+++W + C +L+ H +
Sbjct: 225 ---YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVEC 281
Query: 407 IKWSP----------TGPATSNPNS-SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPV 455
I W+P TG T L S S D T+++WDV G+C TL+ H V
Sbjct: 282 ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWV 341
Query: 456 YSVAFSPDGKYLASGSFDKYVHIWN 480
V F GK++ S + DK + +W+
Sbjct: 342 RGVLFHSGGKFILSCADDKTLRVWD 366
Score = 98.2 bits (243), Expect = 2e-20
Identities = 66/272 (24%), Positives = 126/272 (46%), Gaps = 31/272 (11%)
Query: 272 LGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN-M 330
L H+ P+ + ++ + ++SA D T +WD TG+ ++ H+ D+ + ++
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 331 TFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 390
ASCS DM I + ++T GH + V+++ P+G + S S D T+K+W ++
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223
Query: 391 DACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMK 450
CV H + + ++ + G ++AS S D TVR+W V C L +
Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDGT---------LIASCSNDQTVRVWVVATKECKAELRE 274
Query: 451 HQEPVYSVAFSPD--------------------GKYLASGSFDKYVHIWNTQSGSLVHSY 490
H+ V ++++P+ G +L SGS DK + +W+ +G + +
Sbjct: 275 HEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL 334
Query: 491 QG-TGGIFEVCWNARGDKVGASASDGSVCVLD 521
G + V +++ G + + A D ++ V D
Sbjct: 335 VGHDNWVRGVLFHSGGKFILSCADDKTLRVWD 366
Score = 86.3 bits (212), Expect = 6e-17
Identities = 67/287 (23%), Positives = 114/287 (39%), Gaps = 47/287 (16%)
Query: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE-GGHDVP 233
L+GH V +++ LLAS S D T ++W+ CIR GHD
Sbjct: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE-----------CIRTMHGHD-- 192
Query: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVL 292
+V+S+ +G + S D ++W + G T H+ + ++ N+ G +
Sbjct: 193 --HNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250
Query: 293 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCST--------------- 337
S D+T +W T E K + H + W +++S S
Sbjct: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310
Query: 338 ------DMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD 391
D I + + + T GH N V + + G + SC+DD TL++W K
Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370
Query: 392 ACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438
C+ L AH + ++ + T P + + S D TV++W+
Sbjct: 371 RCMKTLNAHEHFVTSLDFHKTAP---------YVVTGSVDQTVKVWE 408
Score = 34.3 bits (77), Expect = 0.28
Identities = 17/77 (22%), Positives = 39/77 (50%), Gaps = 1/77 (1%)
Query: 446 HTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNAR 504
+ L H+ PV V F P + S S D + +W+ ++G + +G T + ++ ++
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 505 GDKVGASASDGSVCVLD 521
G + + ++D ++ + D
Sbjct: 162 GKLLASCSADMTIKLWD 178
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 116 bits (291), Expect = 4e-26
Identities = 91/329 (27%), Positives = 148/329 (44%), Gaps = 39/329 (11%)
Query: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228
P+ +GH V ++ + LASGS DS +W++ S R
Sbjct: 9 PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFT 58
Query: 229 GHDVPSNKD-VTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQ-HKGPIFALKWNK 286
GH KD VT ++++ G LLA GS D RIW N ST+ + H + ++ +
Sbjct: 59 GH-----KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS 113
Query: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFA-------SCSTDM 339
G ++A DKT +W H +Q+F F + ++W F+ S S D
Sbjct: 114 DGQSFVTASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDK 167
Query: 340 CIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQA 399
+ + V ++ H V + + PSG +A+ D T+K+W ++ + Q
Sbjct: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227
Query: 400 HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVA 459
HS + + + P+G L +AS DST+++ D+ +G +TL HQ P +VA
Sbjct: 228 HSAAVNGLSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
Query: 460 FSPDGKYLASGSFDKYVHIWNTQSGSLVH 488
FS G+Y ASG D+ V +W + + H
Sbjct: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDH 307
Score = 111 bits (278), Expect = 1e-24
Identities = 78/289 (26%), Positives = 128/289 (44%), Gaps = 20/289 (6%)
Query: 238 VTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGV 296
VT +D++ + LA GS D +W + + A HK + + ++ G+ + S
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 297 DKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNMTFASCSTDMCIHVCRLGCDHPVKTF 355
DKT IW + F H+A V + + +F + S D + V + +
Sbjct: 82 DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
Query: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 415
H N V K+ P G L+ S SDD T+K+W CVH H + + + P+G
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
Query: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQE----PVYSVAFSPDGKYLASGS 471
+A+A D+TV++WDV TH L++H + V ++F P G YL + S
Sbjct: 202 ---------IAAAGMDNTVKVWDVR----THRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
Query: 472 FDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCV 519
D + I + G L+++ G G V ++ G+ + SD V V
Sbjct: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Score = 97.4 bits (241), Expect = 3e-20
Identities = 76/268 (28%), Positives = 118/268 (44%), Gaps = 18/268 (6%)
Query: 168 PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 227
P ++A GH+ V ++P LLASGS D T RIW N G ST V R
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW--VPNVKGEST--VFR----- 100
Query: 228 GGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNK 286
V S+ + SDG S D ++W T +L QH + K++
Sbjct: 101 -----AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 155
Query: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMT-FASCSTDMCIHVCR 345
G ++SA DKT +WD + E + H VD+ + T A+ D + V
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Query: 346 LGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIY 405
+ ++ +Q H+ VN + + PSG L + S D TLKI + + ++ L H
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275
Query: 406 TIKWSPTGP--ATSNPNSSIMLASASFD 431
T+ +S TG A+ + +M+ ++FD
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMVWKSNFD 303
Score = 92.4 bits (228), Expect = 9e-19
Identities = 66/216 (30%), Positives = 104/216 (48%), Gaps = 15/216 (6%)
Query: 311 KQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP 369
++ F H VD+ N AS S D C+ V + F GH + V + + P
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 370 SGMLLASCSDDMTLKIW--SMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLAS 427
SG LLAS S D T++IW ++K ++ V +AH+ + ++ + G + +
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120
Query: 428 ASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLV 487
AS D TV++W + +L +H V FSPDG+ + S S DK V +W+ S V
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 488 HSYQGTGG-IFEVCWNARGDKVGASASDGSVCVLDL 522
HSY GG + V ++ G + A+ D +V V D+
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
Score = 91.3 bits (225), Expect = 2e-18
Identities = 60/261 (22%), Positives = 113/261 (43%), Gaps = 11/261 (4%)
Query: 264 ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323
E+ +L H+ + + ++ + S +D ++W +F H
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 324 VDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 382
V++ + AS S D + + F+ HT V ++ + G + SDD T
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 383 LKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG 442
+K+W+ + + L H + K+SP G ++ SAS D TV+LWD
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
Query: 443 VCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ-GTGGIFEVCW 501
C H+ +H V V F P G +A+ D V +W+ ++ L+ YQ + + + +
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
Query: 502 NARGDKVGASASDGSVCVLDL 522
+ G+ + ++SD ++ +LDL
Sbjct: 238 HPSGNYLITASSDSTLKILDL 258
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 116 bits (291), Expect = 4e-26
Identities = 91/329 (27%), Positives = 148/329 (44%), Gaps = 39/329 (11%)
Query: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228
P+ +GH V ++ + LASGS DS +W++ S R
Sbjct: 9 PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFT 58
Query: 229 GHDVPSNKD-VTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQ-HKGPIFALKWNK 286
GH KD VT ++++ G LLA GS D RIW N ST+ + H + ++ +
Sbjct: 59 GH-----KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS 113
Query: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFA-------SCSTDM 339
G ++A DKT +W H +Q+F F + ++W F+ S S D
Sbjct: 114 DGQSFVTASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDK 167
Query: 340 CIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQA 399
+ + V ++ H V + + PSG +A+ D T+K+W ++ + Q
Sbjct: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227
Query: 400 HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVA 459
HS + + + P+G L +AS DST+++ D+ +G +TL HQ P +VA
Sbjct: 228 HSAAVNGLSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
Query: 460 FSPDGKYLASGSFDKYVHIWNTQSGSLVH 488
FS G+Y ASG D+ V +W + + H
Sbjct: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDH 307
Score = 111 bits (278), Expect = 1e-24
Identities = 78/289 (26%), Positives = 128/289 (44%), Gaps = 20/289 (6%)
Query: 238 VTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGV 296
VT +D++ + LA GS D +W + + A HK + + ++ G+ + S
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 297 DKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNMTFASCSTDMCIHVCRLGCDHPVKTF 355
DKT IW + F H+A V + + +F + S D + V + +
Sbjct: 82 DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
Query: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 415
H N V K+ P G L+ S SDD T+K+W CVH H + + + P+G
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
Query: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQE----PVYSVAFSPDGKYLASGS 471
+A+A D+TV++WDV TH L++H + V ++F P G YL + S
Sbjct: 202 ---------IAAAGMDNTVKVWDVR----THRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
Query: 472 FDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCV 519
D + I + G L+++ G G V ++ G+ + SD V V
Sbjct: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Score = 97.4 bits (241), Expect = 3e-20
Identities = 76/268 (28%), Positives = 118/268 (44%), Gaps = 18/268 (6%)
Query: 168 PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 227
P ++A GH+ V ++P LLASGS D T RIW N G ST V R
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW--VPNVKGEST--VFR----- 100
Query: 228 GGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNK 286
V S+ + SDG S D ++W T +L QH + K++
Sbjct: 101 -----AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 155
Query: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMT-FASCSTDMCIHVCR 345
G ++SA DKT +WD + E + H VD+ + T A+ D + V
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Query: 346 LGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIY 405
+ ++ +Q H+ VN + + PSG L + S D TLKI + + ++ L H
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275
Query: 406 TIKWSPTGP--ATSNPNSSIMLASASFD 431
T+ +S TG A+ + +M+ ++FD
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMVWKSNFD 303
Score = 92.4 bits (228), Expect = 9e-19
Identities = 66/216 (30%), Positives = 104/216 (48%), Gaps = 15/216 (6%)
Query: 311 KQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP 369
++ F H VD+ N AS S D C+ V + F GH + V + + P
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 370 SGMLLASCSDDMTLKIW--SMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLAS 427
SG LLAS S D T++IW ++K ++ V +AH+ + ++ + G + +
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120
Query: 428 ASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLV 487
AS D TV++W + +L +H V FSPDG+ + S S DK V +W+ S V
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 488 HSYQGTGG-IFEVCWNARGDKVGASASDGSVCVLDL 522
HSY GG + V ++ G + A+ D +V V D+
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
Score = 91.3 bits (225), Expect = 2e-18
Identities = 60/261 (22%), Positives = 113/261 (43%), Gaps = 11/261 (4%)
Query: 264 ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323
E+ +L H+ + + ++ + S +D ++W +F H
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 324 VDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 382
V++ + AS S D + + F+ HT V ++ + G + SDD T
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 383 LKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG 442
+K+W+ + + L H + K+SP G ++ SAS D TV+LWD
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
Query: 443 VCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ-GTGGIFEVCW 501
C H+ +H V V F P G +A+ D V +W+ ++ L+ YQ + + + +
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
Query: 502 NARGDKVGASASDGSVCVLDL 522
+ G+ + ++SD ++ +LDL
Sbjct: 238 HPSGNYLITASSDSTLKILDL 258
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 116 bits (291), Expect = 4e-26
Identities = 80/292 (27%), Positives = 126/292 (43%), Gaps = 36/292 (12%)
Query: 191 SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLL 250
S L+A G DST R+W++ + K + S+ SD +L+
Sbjct: 482 SSLIAGGFADSTVRVWSV-------------------------TPKKLRSVKQASDLSLI 516
Query: 251 AMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE 309
S D RI E + L H GP++ ++ NY+LS+ D T +W T
Sbjct: 517 DKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576
Query: 310 AKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWD 368
+ H+ P D + F S D + P++ F GH +VN ++
Sbjct: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH 636
Query: 369 PSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASA 428
P+ +A+ S D T+++W + CV H I+++ +SP G LA+
Sbjct: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR---------FLATG 687
Query: 429 SFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480
+ D V LWD+ G+ L H + V S+ FS DG+ LASGS D V +W+
Sbjct: 688 ATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 86.3 bits (212), Expect = 6e-17
Identities = 68/286 (23%), Positives = 127/286 (44%), Gaps = 21/286 (7%)
Query: 238 VTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVD 297
+T++D D +L+A G D R+W+ ++ Q +K+ + VL +D
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLI---DKESDDVLERIMD 529
Query: 298 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFA-SCSTDMCIHVCRLGCDHPVKTFQ 356
+ T E K + HS P + + + S S D + + L + ++
Sbjct: 530 EKT------ASELKILYG-HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK 582
Query: 357 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPAT 416
GH V ++ P G S D ++W+ + H ++ ++ P
Sbjct: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP----- 637
Query: 417 SNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYV 476
+S +A+ S D TVRLWDV G C H+ P++S+ FSP+G++LA+G+ D V
Sbjct: 638 ----NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV 693
Query: 477 HIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCVLD 521
+W+ G +V +G T + + ++ G+ + + + D +V + D
Sbjct: 694 LLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 80.5 bits (197), Expect = 3e-15
Identities = 55/215 (25%), Positives = 96/215 (44%), Gaps = 16/215 (7%)
Query: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233
+L GH V+ +++P + L S S D T R+W+L + GH+ P
Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ----------TFTCLVGYKGHNYP 587
Query: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVL 292
V ++ G G +D AR+W T++ H + +++ NYV
Sbjct: 588 ----VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
Query: 293 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF-ASCSTDMCIHVCRLGCDHP 351
+ D+T +WD G + F H P + + N F A+ +TD + + +G
Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703
Query: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386
V +GHT+ V ++++ G +LAS S D T+++W
Sbjct: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 60.1 bits (144), Expect = 5e-09
Identities = 37/133 (27%), Positives = 67/133 (50%), Gaps = 15/133 (11%)
Query: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233
+ GH ++V ++P S+ +A+GS D T R+W++ NG ++ GH P
Sbjct: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDV---LNGNCVRIFT-------GHKGP 671
Query: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVL 292
+ SL ++ +G LA G+ DG +W +G + L H + +L++++ G +
Sbjct: 672 ----IHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILA 727
Query: 293 SAGVDKTTIIWDA 305
S +D T +WDA
Sbjct: 728 SGSMDNTVRLWDA 740
Score = 39.3 bits (90), Expect = 0.009
Identities = 24/93 (25%), Positives = 39/93 (41%), Gaps = 14/93 (15%)
Query: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229
N + GH+ + ++P LA+G+ D +W++ G + G
Sbjct: 660 NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELK----------G 709
Query: 230 HDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW 262
H V SL ++ DG +LA GS D R+W
Sbjct: 710 H----TDTVCSLRFSRDGEILASGSMDNTVRLW 738
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 111 bits (278), Expect = 1e-24
Identities = 85/322 (26%), Positives = 133/322 (41%), Gaps = 65/322 (20%)
Query: 168 PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 227
P ++A GH+ V ++P LLASGS D T RIW N G + + H
Sbjct: 12 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK---GESTVFRAH---- 64
Query: 228 GGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNK 286
V S+ + SDG S D ++W T +L QH + K++
Sbjct: 65 -------TATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117
Query: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRL 346
G ++SA DKT +WD + E C+H
Sbjct: 118 DGRLIVSASDDKTVKLWDKSSRE------------------------------CVH---- 143
Query: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
++ H V + + PSG +A+ D T+K+W ++ + Q HS +
Sbjct: 144 -------SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 196
Query: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKY 466
+ + P+G L +AS DST+++ D+ +G +TL HQ P +VAFS G+Y
Sbjct: 197 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 247
Query: 467 LASGSFDKYVHIWNTQSGSLVH 488
ASG D+ V +W + + H
Sbjct: 248 FASGGSDEQVMVWKSNFDIVDH 269
Score = 102 bits (255), Expect = 7e-22
Identities = 68/251 (27%), Positives = 111/251 (44%), Gaps = 19/251 (7%)
Query: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNMTFA 333
HK + + ++ G+ + S DKT IW + F H+A V + + +F
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81
Query: 334 SCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDAC 393
+ S D + V + + H N V K+ P G L+ S SDD T+K+W C
Sbjct: 82 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 141
Query: 394 VHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQE 453
VH H + + + P+G +A+A D+TV++WDV TH L++H +
Sbjct: 142 VHSYCEHGGFVTYVDFHPSGTC---------IAAAGMDNTVKVWDVR----THRLLQHYQ 188
Query: 454 ----PVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKV 508
V ++F P G YL + S D + I + G L+++ G G V ++ G+
Sbjct: 189 LHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYF 248
Query: 509 GASASDGSVCV 519
+ SD V V
Sbjct: 249 ASGGSDEQVMV 259
Score = 87.4 bits (215), Expect = 3e-17
Identities = 56/229 (24%), Positives = 101/229 (44%), Gaps = 11/229 (4%)
Query: 296 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKT 354
+D ++W +F H V++ + AS S D + +
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 355 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGP 414
F+ HT V ++ + G + SDD T+K+W+ + + L H + K+SP G
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 415 ATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDK 474
++ SAS D TV+LWD C H+ +H V V F P G +A+ D
Sbjct: 121 ---------LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 171
Query: 475 YVHIWNTQSGSLVHSYQ-GTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
V +W+ ++ L+ YQ + + + ++ G+ + ++SD ++ +LDL
Sbjct: 172 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL 220
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 109 bits (273), Expect = 5e-24
Identities = 73/279 (26%), Positives = 126/279 (45%), Gaps = 21/279 (7%)
Query: 247 GTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDA 305
G + GS D ++W+ G TL H G +++ + + N ++S D+T +W+A
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 330
Query: 306 HTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAI 365
TGE H++ + S S D + V + + GH V +
Sbjct: 331 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 389
Query: 366 KWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIML 425
++D G + S + D +K+W + + C+H LQ H+ +Y++++ I +
Sbjct: 390 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 436
Query: 426 ASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGS 485
S S D+++R+WDVE G C HTL HQ + + L SG+ D V IW+ ++G
Sbjct: 437 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 494
Query: 486 LVHSYQGTG--GIFEVCWNARGDKVGASASDGSVCVLDL 522
+ + QG C + V S+ DG+V + DL
Sbjct: 495 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 533
Score = 78.2 bits (191), Expect = 2e-14
Identities = 74/305 (24%), Positives = 122/305 (40%), Gaps = 61/305 (20%)
Query: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE-GGHDV 232
VL+GH+ V C + + SGS D+T ++W+ V C+R GH
Sbjct: 257 VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSA-----------VTGKCLRTLVGH-- 302
Query: 233 PSNKDVTSLDWNSD--GTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGN 289
T W+S ++ GS D ++W E G TL H + + ++K
Sbjct: 303 ------TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR- 355
Query: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
V+S D T +WD TG+ H A V + S + D + V +
Sbjct: 356 -VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYDFMVKVWDPETE 413
Query: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSK------- 402
+ T QGHTN V ++++D G+ + S S D ++++W ++ C+H L H
Sbjct: 414 TCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL 471
Query: 403 --------------EIYTIKWSPTGPATSNPN-----------SSIMLASASFDSTVRLW 437
+I+ IK PN + + ++S D TV+LW
Sbjct: 472 KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 531
Query: 438 DVEQG 442
D++ G
Sbjct: 532 DLKTG 536
Score = 61.6 bits (148), Expect = 2e-09
Identities = 46/208 (22%), Positives = 97/208 (46%), Gaps = 25/208 (12%)
Query: 194 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMG 253
+ SGS D+T R+W++ G +++ H V + + DG + G
Sbjct: 356 VVSGSRDATLRVWDIE---TGQCLHVLMGHVAA-----------VRCVQY--DGRRVVSG 399
Query: 254 SYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQ 312
+YD ++W E TL H +++L+++ G +V+S +D + +WD TG
Sbjct: 400 AYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIH 457
Query: 313 QFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQG---HTNEVNAIKWDP 369
H + ++ ++N+ S + D + + + ++T QG H + V ++++
Sbjct: 458 TLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK 516
Query: 370 SGMLLASCSDDMTLKIWSMKQDACVHDL 397
+ ++ +S DD T+K+W +K + +L
Sbjct: 517 NFVITSS--DDGTVKLWDLKTGEFIRNL 542
Score = 47.8 bits (112), Expect = 2e-05
Identities = 36/139 (25%), Positives = 67/139 (48%), Gaps = 24/139 (17%)
Query: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
L+GH + V+ ++ + + SGS D++ R+W++ + CI H +
Sbjct: 419 LQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN-----------CI----HTLTG 461
Query: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTL---GQHKGPIFALKWNKKGNY 290
++ +TS +L G+ D +IW + G TL +H+ + L++NK N+
Sbjct: 462 HQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NF 518
Query: 291 VLSAGVDKTTIIWDAHTGE 309
V+++ D T +WD TGE
Sbjct: 519 VITSSDDGTVKLWDLKTGE 537
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 109 bits (273), Expect = 5e-24
Identities = 73/279 (26%), Positives = 126/279 (45%), Gaps = 21/279 (7%)
Query: 247 GTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDA 305
G + GS D ++W+ G TL H G +++ + + N ++S D+T +W+A
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 448
Query: 306 HTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAI 365
TGE H++ + S S D + V + + GH V +
Sbjct: 449 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
Query: 366 KWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIML 425
++D G + S + D +K+W + + C+H LQ H+ +Y++++ I +
Sbjct: 508 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 554
Query: 426 ASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGS 485
S S D+++R+WDVE G C HTL HQ + + L SG+ D V IW+ ++G
Sbjct: 555 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 612
Query: 486 LVHSYQGTG--GIFEVCWNARGDKVGASASDGSVCVLDL 522
+ + QG C + V S+ DG+V + DL
Sbjct: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 651
Score = 78.2 bits (191), Expect = 2e-14
Identities = 74/305 (24%), Positives = 122/305 (40%), Gaps = 61/305 (20%)
Query: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE-GGHDV 232
VL+GH+ V C + + SGS D+T ++W+ V C+R GH
Sbjct: 375 VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSA-----------VTGKCLRTLVGH-- 420
Query: 233 PSNKDVTSLDWNSD--GTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGN 289
T W+S ++ GS D ++W E G TL H + + ++K
Sbjct: 421 ------TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR- 473
Query: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
V+S D T +WD TG+ H A V + S + D + V +
Sbjct: 474 -VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYDFMVKVWDPETE 531
Query: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSK------- 402
+ T QGHTN V ++++D G+ + S S D ++++W ++ C+H L H
Sbjct: 532 TCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL 589
Query: 403 --------------EIYTIKWSPTGPATSNPN-----------SSIMLASASFDSTVRLW 437
+I+ IK PN + + ++S D TV+LW
Sbjct: 590 KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 649
Query: 438 DVEQG 442
D++ G
Sbjct: 650 DLKTG 654
Score = 61.6 bits (148), Expect = 2e-09
Identities = 46/208 (22%), Positives = 97/208 (46%), Gaps = 25/208 (12%)
Query: 194 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMG 253
+ SGS D+T R+W++ G +++ H V + + DG + G
Sbjct: 474 VVSGSRDATLRVWDIE---TGQCLHVLMGHVAA-----------VRCVQY--DGRRVVSG 517
Query: 254 SYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQ 312
+YD ++W E TL H +++L+++ G +V+S +D + +WD TG
Sbjct: 518 AYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIH 575
Query: 313 QFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQG---HTNEVNAIKWDP 369
H + ++ ++N+ S + D + + + ++T QG H + V ++++
Sbjct: 576 TLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK 634
Query: 370 SGMLLASCSDDMTLKIWSMKQDACVHDL 397
+ ++ +S DD T+K+W +K + +L
Sbjct: 635 NFVITSS--DDGTVKLWDLKTGEFIRNL 660
Score = 47.8 bits (112), Expect = 2e-05
Identities = 36/139 (25%), Positives = 67/139 (48%), Gaps = 24/139 (17%)
Query: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
L+GH + V+ ++ + + SGS D++ R+W++ + CI H +
Sbjct: 537 LQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN-----------CI----HTLTG 579
Query: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTL---GQHKGPIFALKWNKKGNY 290
++ +TS +L G+ D +IW + G TL +H+ + L++NK N+
Sbjct: 580 HQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NF 636
Query: 291 VLSAGVDKTTIIWDAHTGE 309
V+++ D T +WD TGE
Sbjct: 637 VITSSDDGTVKLWDLKTGE 655
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 109 bits (273), Expect = 5e-24
Identities = 73/279 (26%), Positives = 126/279 (45%), Gaps = 21/279 (7%)
Query: 247 GTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDA 305
G + GS D ++W+ G TL H G +++ + + N ++S D+T +W+A
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 368
Query: 306 HTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAI 365
TGE H++ + S S D + V + + GH V +
Sbjct: 369 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 427
Query: 366 KWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIML 425
++D G + S + D +K+W + + C+H LQ H+ +Y++++ I +
Sbjct: 428 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 474
Query: 426 ASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGS 485
S S D+++R+WDVE G C HTL HQ + + L SG+ D V IW+ ++G
Sbjct: 475 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 532
Query: 486 LVHSYQGTG--GIFEVCWNARGDKVGASASDGSVCVLDL 522
+ + QG C + V S+ DG+V + DL
Sbjct: 533 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 571
Score = 78.2 bits (191), Expect = 2e-14
Identities = 74/305 (24%), Positives = 122/305 (40%), Gaps = 61/305 (20%)
Query: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE-GGHDV 232
VL+GH+ V C + + SGS D+T ++W+ V C+R GH
Sbjct: 295 VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSA-----------VTGKCLRTLVGH-- 340
Query: 233 PSNKDVTSLDWNSD--GTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGN 289
T W+S ++ GS D ++W E G TL H + + ++K
Sbjct: 341 ------TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR- 393
Query: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
V+S D T +WD TG+ H A V + S + D + V +
Sbjct: 394 -VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYDFMVKVWDPETE 451
Query: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSK------- 402
+ T QGHTN V ++++D G+ + S S D ++++W ++ C+H L H
Sbjct: 452 TCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL 509
Query: 403 --------------EIYTIKWSPTGPATSNPN-----------SSIMLASASFDSTVRLW 437
+I+ IK PN + + ++S D TV+LW
Sbjct: 510 KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 569
Query: 438 DVEQG 442
D++ G
Sbjct: 570 DLKTG 574
Score = 61.6 bits (148), Expect = 2e-09
Identities = 46/208 (22%), Positives = 97/208 (46%), Gaps = 25/208 (12%)
Query: 194 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMG 253
+ SGS D+T R+W++ G +++ H V + + DG + G
Sbjct: 394 VVSGSRDATLRVWDIE---TGQCLHVLMGHVAA-----------VRCVQY--DGRRVVSG 437
Query: 254 SYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQ 312
+YD ++W E TL H +++L+++ G +V+S +D + +WD TG
Sbjct: 438 AYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIH 495
Query: 313 QFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQG---HTNEVNAIKWDP 369
H + ++ ++N+ S + D + + + ++T QG H + V ++++
Sbjct: 496 TLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK 554
Query: 370 SGMLLASCSDDMTLKIWSMKQDACVHDL 397
+ ++ +S DD T+K+W +K + +L
Sbjct: 555 NFVITSS--DDGTVKLWDLKTGEFIRNL 580
Score = 47.8 bits (112), Expect = 2e-05
Identities = 36/139 (25%), Positives = 67/139 (48%), Gaps = 24/139 (17%)
Query: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
L+GH + V+ ++ + + SGS D++ R+W++ + CI H +
Sbjct: 457 LQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN-----------CI----HTLTG 499
Query: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTL---GQHKGPIFALKWNKKGNY 290
++ +TS +L G+ D +IW + G TL +H+ + L++NK N+
Sbjct: 500 HQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NF 556
Query: 291 VLSAGVDKTTIIWDAHTGE 309
V+++ D T +WD TGE
Sbjct: 557 VITSSDDGTVKLWDLKTGE 575
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 103 bits (258), Expect = 3e-22
Identities = 84/302 (27%), Positives = 131/302 (43%), Gaps = 29/302 (9%)
Query: 178 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKD 237
H EV A++P +L +GS D W S QL+ R GGH P
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETR------SGQLLWRL----GGHTGP---- 65
Query: 238 VTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGV 296
V ++ DG L A S D R+W L H+ + + ++ + S G
Sbjct: 66 VKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGW 125
Query: 297 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMT-FASCSTDMCIHVCRLGCDHPVKTF 355
DK ++WD +G+ + H D+ + A+ S D +H+ L P +
Sbjct: 126 DKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSH 185
Query: 356 Q---GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Q GH+ ++ + + SG LLAS S D T+ IW + + L+ H + +I +SP
Sbjct: 186 QALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP- 243
Query: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSF 472
+ LASA + V++WD G C TL + ++ AF+PDGK L SG+
Sbjct: 244 --------DELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAA 295
Query: 473 DK 474
D+
Sbjct: 296 DQ 297
Score = 102 bits (255), Expect = 7e-22
Identities = 72/269 (26%), Positives = 121/269 (44%), Gaps = 15/269 (5%)
Query: 237 DVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAG 295
+V S ++ DG +L GS DG W T +G L LG H GP+ +++ G+ SA
Sbjct: 23 EVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASAS 82
Query: 296 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKT 354
D T +WD + + H V + ++ AS D + + + ++
Sbjct: 83 CDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRL 142
Query: 355 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ--DACVHD-LQAHSKEIYTIKWSP 411
GH + + + + P+ LA+ S D T+ IW ++ A H L+ HS I + +S
Sbjct: 143 LVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA 202
Query: 412 TGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGS 471
+G +LAS S+D T+ +W L H V S+AFSPD +LAS
Sbjct: 203 SG----------LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAG 252
Query: 472 FDKYVHIWNTQSGSLVHSYQGTGGIFEVC 500
+ + V +W+ +G + + +G + C
Sbjct: 253 YSRMVKVWDCNTGKCLETLKGVLDVAHTC 281
Score = 94.4 bits (233), Expect = 2e-19
Identities = 55/174 (31%), Positives = 86/174 (49%), Gaps = 13/174 (7%)
Query: 336 STDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVH 395
S D C++ + GHT V ++ P G L AS S D T+++W + + C+
Sbjct: 40 SEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLR 99
Query: 396 DLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPV 455
L+ H + + T+ +SP S LAS +D V LWDV+ G L+ H++ +
Sbjct: 100 VLKGHQRSVETVSFSP---------DSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSI 150
Query: 456 YSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG----IFEVCWNARG 505
S FSP LA+GS+D VHIW+ + + S+Q G I +C++A G
Sbjct: 151 QSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG 204
Score = 93.6 bits (231), Expect = 4e-19
Identities = 52/141 (36%), Positives = 74/141 (52%), Gaps = 9/141 (6%)
Query: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSP 411
VK F H EVN+ + P G +L + S+D + W + + L H+ + ++SP
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
Query: 412 TGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGS 471
G + ASAS D TVRLWDV + C L HQ V +V+FSPD + LASG
Sbjct: 74 DGH---------LFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGG 124
Query: 472 FDKYVHIWNTQSGSLVHSYQG 492
+DK V +W+ QSG ++ G
Sbjct: 125 WDKRVMLWDVQSGQMLRLLVG 145
Score = 75.5 bits (184), Expect = 1e-13
Identities = 60/244 (24%), Positives = 100/244 (40%), Gaps = 20/244 (8%)
Query: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE-GGHDVP 233
L GH V C ++P L AS S D T R+W+ + C+R GH
Sbjct: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD-----------VARAKCLRVLKGH--- 104
Query: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVL 292
+ V ++ ++ D LA G +D +W ++G + L H+ I + ++ N +
Sbjct: 105 -QRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLA 163
Query: 293 SAGVDKTTIIWDAH---TGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
+ D T IWD + Q HSA + + + AS S D IH+ +
Sbjct: 164 TGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTS 223
Query: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKW 409
+ +GH V +I + P + LAS +K+W C+ L+ +T +
Sbjct: 224 SLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF 283
Query: 410 SPTG 413
+P G
Sbjct: 284 TPDG 287
Score = 51.2 bits (121), Expect = 2e-06
Identities = 53/220 (24%), Positives = 83/220 (37%), Gaps = 32/220 (14%)
Query: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233
VL+GH+ V +++P S LASG D +W++ +G +L++ H
Sbjct: 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV---QSGQMLRLLVGH---------- 146
Query: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW----TENGNLASTLGQHKGPIFALKWNKKGN 289
+ S D++ LA GS+D IW L H I L ++ G
Sbjct: 147 -RDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG- 204
Query: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF-------ASCSTDMCIH 342
+ S DKT IW T Q H V W ++ F AS +
Sbjct: 205 LLASGSWDKTIHIWKPTTSSLLIQLKGH------VTWVKSIAFSPDELWLASAGYSRMVK 258
Query: 343 VCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 382
V ++T +G + + + P G +L S + D T
Sbjct: 259 VWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Score = 42.7 bits (99), Expect = 8e-04
Identities = 26/64 (40%), Positives = 35/64 (54%)
Query: 450 KHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVG 509
+H V S AFSPDG+ L +GS D V+ W T+SG L+ G G + C + +
Sbjct: 19 QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 510 ASAS 513
ASAS
Sbjct: 79 ASAS 82
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 103 bits (256), Expect = 5e-22
Identities = 74/295 (25%), Positives = 144/295 (48%), Gaps = 31/295 (10%)
Query: 237 DVTSLDWNSDGTLLAMGSYDGFARIWTENGNLAS--TLGQHKGPIFALKWNKKGNYVLSA 294
+V ++ +G+ LA +D +W G+ + TL H G + L +N G+ + SA
Sbjct: 68 EVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSA 127
Query: 295 GVDKTTIIWDAHTGEAKQQFPFHSA------PALDVDWQNNMTFASCSTDMCIHVCRLGC 348
DKT +WD+ TGE ++ H++ PA + + S D + + +
Sbjct: 128 STDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR----RGPQLVCTGSDDGTVKLWDIRK 183
Query: 349 DHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIK 408
++TFQ +T +V A+ ++ + + S D +K+W ++Q+ + ++ H+ +
Sbjct: 184 KAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSV---- 238
Query: 409 WSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMK--------HQEPVYSVAF 460
TG + S+ S L S + D+TVR+WDV +K ++ + ++
Sbjct: 239 ---TGLSLSSEGS--YLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSW 293
Query: 461 SPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASD 514
SPDG +A+GS D++V++W+T S +++ G G I EV ++ + +++SD
Sbjct: 294 SPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
Score = 99.4 bits (246), Expect = 7e-21
Identities = 67/263 (25%), Positives = 126/263 (47%), Gaps = 24/263 (9%)
Query: 272 LGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQNN 329
L H+G ++ K++ G+ + SAG D+ ++W+ + G+ HS +++ + +
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD 120
Query: 330 MTFA-SCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSG-MLLASCSDDMTLKIWS 387
+ S STD + V VK +GHT+ VN+ G L+ + SDD T+K+W
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
Query: 388 MKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHT 447
+++ A + Q ++ ++ + ++ T S + S D+ +++WD+ Q T+T
Sbjct: 181 IRKKAAIQTFQ-NTYQVLAVTFNDT---------SDQIISGGIDNDIKVWDLRQNKLTYT 230
Query: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQ----SGSLVHSYQGTGGIFE----- 498
+ H + V ++ S +G YL S + D V +W+ + V +QG FE
Sbjct: 231 MRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLR 290
Query: 499 VCWNARGDKVGASASDGSVCVLD 521
W+ G K+ A ++D V V D
Sbjct: 291 CSWSPDGSKIAAGSADRFVYVWD 313
Score = 71.6 bits (174), Expect = 2e-12
Identities = 50/174 (28%), Positives = 79/174 (45%), Gaps = 11/174 (6%)
Query: 351 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVH-DLQAHSKEIYTIKW 409
P+ GH EV K+ P+G LAS D + +W++ D + L+ HS + + +
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117
Query: 410 SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL-A 468
+ G ML SAS D TV +WD E G L H V S + G L
Sbjct: 118 NTDGS---------MLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVC 168
Query: 469 SGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
+GS D V +W+ + + + ++Q T + V +N D++ + D + V DL
Sbjct: 169 TGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDL 222
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.129 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,907,642
Number of Sequences: 37866
Number of extensions: 932235
Number of successful extensions: 6668
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 263
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 2386
Number of HSP's gapped (non-prelim): 1925
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.