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Search of human proteins with 15149465
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15149465 caldesmon 1 isoform 5 [Homo sapiens]
(532 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15149465 caldesmon 1 isoform 5 [Homo sapiens] 1040 0.0
gi|15149463 caldesmon 1 isoform 4 [Homo sapiens] 1026 0.0
gi|4826657 caldesmon 1 isoform 2 [Homo sapiens] 1007 0.0
gi|15149467 caldesmon 1 isoform 3 [Homo sapiens] 993 0.0
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 692 0.0
gi|148746195 trichohyalin [Homo sapiens] 100 6e-21
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 93 5e-19
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 92 9e-19
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 92 9e-19
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 91 3e-18
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 89 8e-18
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 89 1e-17
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 88 2e-17
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 88 2e-17
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 88 2e-17
gi|20070205 ladinin 1 [Homo sapiens] 88 2e-17
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 81 2e-15
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 80 4e-15
gi|148839339 nexilin (F actin binding protein) [Homo sapiens] 80 5e-15
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 79 8e-15
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 79 1e-14
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 78 2e-14
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 78 2e-14
gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s... 78 2e-14
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 77 3e-14
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 77 3e-14
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 77 3e-14
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 77 3e-14
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 77 3e-14
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 77 3e-14
>gi|15149465 caldesmon 1 isoform 5 [Homo sapiens]
Length = 532
Score = 1040 bits (2690), Expect = 0.0
Identities = 532/532 (100%), Positives = 532/532 (100%)
Query: 1 MLGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 60
MLGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV
Sbjct: 1 MLGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 60
Query: 61 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 120
EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT
Sbjct: 61 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 120
Query: 121 DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE 180
DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE
Sbjct: 121 DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE 180
Query: 181 DKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH 240
DKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH
Sbjct: 181 DKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH 240
Query: 241 KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA 300
KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA
Sbjct: 241 KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA 300
Query: 301 ALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 360
ALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK
Sbjct: 301 ALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 360
Query: 361 MPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQ 420
MPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQ
Sbjct: 361 MPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQ 420
Query: 421 YTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVG 480
YTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVG
Sbjct: 421 YTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVG 480
Query: 481 VSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 532
VSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV
Sbjct: 481 VSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 532
>gi|15149463 caldesmon 1 isoform 4 [Homo sapiens]
Length = 558
Score = 1026 bits (2653), Expect = 0.0
Identities = 532/558 (95%), Positives = 532/558 (95%), Gaps = 26/558 (4%)
Query: 1 MLGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 60
MLGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV
Sbjct: 1 MLGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 60
Query: 61 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 120
EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT
Sbjct: 61 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 120
Query: 121 DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE 180
DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE
Sbjct: 121 DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE 180
Query: 181 DKEKEEEEEEKPKRGSIGENQ--------------------------IKDEKIKKDKEPK 214
DKEKEEEEEEKPKRGSIGENQ IKDEKIKKDKEPK
Sbjct: 181 DKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPK 240
Query: 215 EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 274
EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR
Sbjct: 241 EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 300
Query: 275 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 334
LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL
Sbjct: 301 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 360
Query: 335 REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNK 394
REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNK
Sbjct: 361 REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNK 420
Query: 395 SVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSM 454
SVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSM
Sbjct: 421 SVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSM 480
Query: 455 WEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSK 514
WEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSK
Sbjct: 481 WEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSK 540
Query: 515 RNLWEKQSVDKVTSPTKV 532
RNLWEKQSVDKVTSPTKV
Sbjct: 541 RNLWEKQSVDKVTSPTKV 558
>gi|4826657 caldesmon 1 isoform 2 [Homo sapiens]
Length = 538
Score = 1007 bits (2603), Expect = 0.0
Identities = 514/515 (99%), Positives = 515/515 (100%)
Query: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
+IAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT
Sbjct: 24 RIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 83
Query: 78 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE
Sbjct: 84 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
Query: 138 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 197
NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI
Sbjct: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
Query: 198 GENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS 257
GENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS
Sbjct: 204 GENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS 263
Query: 258 VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 317
VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV
Sbjct: 264 VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 323
Query: 318 LEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFT 377
LEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFT
Sbjct: 324 LEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFT 383
Query: 378 PKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPA 437
PKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPA
Sbjct: 384 PKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPA 443
Query: 438 ASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNK 497
ASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNK
Sbjct: 444 ASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNK 503
Query: 498 SPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 532
SPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV
Sbjct: 504 SPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 538
Score = 53.5 bits (127), Expect = 5e-07
Identities = 56/244 (22%), Positives = 105/244 (43%), Gaps = 37/244 (15%)
Query: 144 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE--EEKPKRGSIGENQ 201
E + E R+++ E E +YQ+ND D EE +E + + +E +K + S+G+
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLGQVT 63
Query: 202 IKDEKIKKDKEPKEEVKSFM-------DRKKGFTEVKSQNGEFMTHKLKH---------- 244
+ E ++ P EE K+ D + F E ++ E +L+
Sbjct: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
Query: 245 --TENTFSRPGGRASVDTKEAEGAPQVEAGK-RLEELRRRRGETESEEFEKLKQKQQEAA 301
T+ + S P R DT E E + E + R E ET ++ ++K + E
Sbjct: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE-- 181
Query: 302 LELEELKKKREERRKVLEEEEQRRKQEEADRKLREE------EEKRRLKEEIERRRAEAA 355
+ K+E++ K EEEE+ ++ + ++++E E K +K ++R++
Sbjct: 182 ------ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTE 235
Query: 356 EKRQ 359
K Q
Sbjct: 236 VKSQ 239
Score = 33.5 bits (75), Expect = 0.50
Identities = 36/177 (20%), Positives = 77/177 (43%), Gaps = 39/177 (22%)
Query: 275 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR-EERRKVLEEEEQRRKQEEADRK 333
+++ RRR E +QK++E LE E + +R ++ + E +RR ++E R+
Sbjct: 1 MDDFERRR--------ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ 52
Query: 334 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 393
+EEE ++ +++E + +P++ T + ++ ++ A FL
Sbjct: 53 KQEEESLGQVTDQVE------VNAQNSVPDEEAKT--------TTTNTQVEGDDEAAFLE 98
Query: 394 KSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN 450
+ ++ + R ++ A+E K PT AS L +P+ ++N
Sbjct: 99 RLARRE---------------ERRQKRLQEALERQKEFDPTITDAS-LSLPSRRMQN 139
Score = 30.8 bits (68), Expect = 3.2
Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 27/166 (16%)
Query: 273 KRLEELRRRRGETESEEFEKL---KQKQQEAALELEELKKKREERRKVLEEEEQ-----R 324
+R ELRR++ E E E++ + E E ++ R+ER + +EEE
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 325 RKQEEADRKLREEEEK-RRLKEEIE--------RRRAEAAEKRQKMPEDGLSDDKKPFKC 375
+ + A + +EE K ++E R A E+RQK ++ L K+
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Query: 376 FTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQY 421
T SL ++ +Q + T + K +SR E+Y
Sbjct: 125 ITDASLSLP--------SRRMQNDTAENETTEKE--EKSESRQERY 160
>gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]
Length = 564
Score = 993 bits (2566), Expect = 0.0
Identities = 514/541 (95%), Positives = 515/541 (95%), Gaps = 26/541 (4%)
Query: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
+IAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT
Sbjct: 24 RIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 83
Query: 78 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE
Sbjct: 84 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
Query: 138 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 197
NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI
Sbjct: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
Query: 198 GENQ--------------------------IKDEKIKKDKEPKEEVKSFMDRKKGFTEVK 231
GENQ IKDEKIKKDKEPKEEVKSFMDRKKGFTEVK
Sbjct: 204 GENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVK 263
Query: 232 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 291
SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE
Sbjct: 264 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 323
Query: 292 KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 351
KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR
Sbjct: 324 KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 383
Query: 352 AEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV 411
AEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV
Sbjct: 384 AEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV 443
Query: 412 SKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPN 471
SKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPN
Sbjct: 444 SKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPN 503
Query: 472 KETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK 531
KETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK
Sbjct: 504 KETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK 563
Query: 532 V 532
V
Sbjct: 564 V 564
Score = 57.4 bits (137), Expect = 3e-08
Identities = 64/276 (23%), Positives = 122/276 (44%), Gaps = 19/276 (6%)
Query: 144 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE--EEKPKRGSIGENQ 201
E + E R+++ E E +YQ+ND D EE +E + + +E +K + S+G+
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLGQVT 63
Query: 202 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK 261
+ E ++ P EE K+ T+V+ + +L E + A K
Sbjct: 64 DQVEVNAQNSVPDEEAKTTTTN----TQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
Query: 262 EAEGAPQV-EAGKRLEELRRRRGETESEEFEK-LKQKQQEAALELEELKKKREERRKVLE 319
E + P + +A L R + E+E EK K + ++ E+EE + + +K
Sbjct: 120 EFD--PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDW 177
Query: 320 EEEQRRKQEEADRKLREEEEKRR---LKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCF 376
+ + K+E+ +++ EEE+ +R + + E + + KR+K+ ED + K+ K
Sbjct: 178 RDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE 237
Query: 377 TPKGSSLKIEERAEFLNK-----SVQKSSGVKSTHQ 407
K EE F+++ V+ +G TH+
Sbjct: 238 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHK 273
Score = 33.5 bits (75), Expect = 0.50
Identities = 36/177 (20%), Positives = 77/177 (43%), Gaps = 39/177 (22%)
Query: 275 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR-EERRKVLEEEEQRRKQEEADRK 333
+++ RRR E +QK++E LE E + +R ++ + E +RR ++E R+
Sbjct: 1 MDDFERRR--------ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ 52
Query: 334 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 393
+EEE ++ +++E + +P++ T + ++ ++ A FL
Sbjct: 53 KQEEESLGQVTDQVE------VNAQNSVPDEEAKT--------TTTNTQVEGDDEAAFLE 98
Query: 394 KSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN 450
+ ++ + R ++ A+E K PT AS L +P+ ++N
Sbjct: 99 RLARRE---------------ERRQKRLQEALERQKEFDPTITDAS-LSLPSRRMQN 139
Score = 30.8 bits (68), Expect = 3.2
Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 27/166 (16%)
Query: 273 KRLEELRRRRGETESEEFEKL---KQKQQEAALELEELKKKREERRKVLEEEEQ-----R 324
+R ELRR++ E E E++ + E E ++ R+ER + +EEE
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 325 RKQEEADRKLREEEEK-RRLKEEIE--------RRRAEAAEKRQKMPEDGLSDDKKPFKC 375
+ + A + +EE K ++E R A E+RQK ++ L K+
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Query: 376 FTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQY 421
T SL ++ +Q + T + K +SR E+Y
Sbjct: 125 ITDASLSLP--------SRRMQNDTAENETTEKE--EKSESRQERY 160
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 692 bits (1786), Expect = 0.0
Identities = 372/518 (71%), Positives = 412/518 (79%), Gaps = 26/518 (5%)
Query: 23 RNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS------VPDEEAKTT 76
R + +E+ AA+ER RR +ER R ++EE+ + +++ + + + +EE +
Sbjct: 294 RIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA 353
Query: 77 TTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 136
+++ +++ A ER R E +K E +R K+ + + A
Sbjct: 354 EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLE---------------EKKHA 398
Query: 137 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK--KEDKEKEEEEEEKPKR 194
ET K EK E + E + E + Q + E K K ++E+ +E+KP
Sbjct: 399 MQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKP-- 456
Query: 195 GSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG 254
+ + +IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG
Sbjct: 457 -TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG 515
Query: 255 RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 314
RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER
Sbjct: 516 RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 575
Query: 315 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 374
RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK
Sbjct: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 635
Query: 375 CFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPT 434
CFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPT
Sbjct: 636 CFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPT 695
Query: 435 KPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPD 494
KPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPD
Sbjct: 696 KPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPD 755
Query: 495 GNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 532
GNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV
Sbjct: 756 GNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 793
Score = 414 bits (1063), Expect = e-115
Identities = 262/518 (50%), Positives = 320/518 (61%), Gaps = 26/518 (5%)
Query: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
+IAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT
Sbjct: 24 RIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 83
Query: 78 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE
Sbjct: 84 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
Query: 138 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 197
NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI
Sbjct: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
Query: 198 GENQIKDEKIKKDKEPKEE--VKSFMDRKKGFTEVKSQ------NGEFMTHKLKHTENTF 249
GENQ++ +K E +EE V S + + E K + + E H+ E+
Sbjct: 204 GENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKE 263
Query: 250 SRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKK 309
RA ++ +E E + K +E R E ++ E+ +++ +E EE K+
Sbjct: 264 RAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKR 323
Query: 310 KREERRKVLEEEE------QRRKQEE---ADRKLREEEEKRRLKEEIERRRAEAAEK--- 357
EER+++ EEE+ QR K+EE A+ + R +EE++R EE +R RAE EK
Sbjct: 324 AAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKV 383
Query: 358 RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSR 417
++ L + K + KG K+E++ E K V + + Q A++ K
Sbjct: 384 EEQKRNKQLEEKKHAMQETKIKGE--KVEQKIE--GKWVNEKKAQEDKLQTAVLKKQGE- 438
Query: 418 LEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGL 477
E+ T + + KP + E ++ K E+ F T K G
Sbjct: 439 -EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE 497
Query: 478 KVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKR 515
+ + E P G S K ++ P + KR
Sbjct: 498 FMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 535
Score = 53.5 bits (127), Expect = 5e-07
Identities = 81/359 (22%), Positives = 151/359 (42%), Gaps = 70/359 (19%)
Query: 144 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE--EEKPKRGSIGENQ 201
E + E R+++ E E +YQ+ND D EE +E + + +E +K + S+G+
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLGQVT 63
Query: 202 IKDEKIKKDKEPKEEVKSFM-------DRKKGFTEVKSQNGEFMTHKLKH---------- 244
+ E ++ P EE K+ D + F E ++ E +L+
Sbjct: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
Query: 245 --TENTFSRPGGRASVDTKEAEGAPQVEAGK-RLEELRRRRGETESEEFEK-------LK 294
T+ + S P R DT E E + E + R E ET ++ ++K
Sbjct: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
Query: 295 QKQQEAALELEELKKKR----EERRKVLEEEEQRRKQEE-----------ADRKLREEEE 339
+K+ + E EE K KR E + +V+ EE+ QEE + + ++EEE
Sbjct: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243
Query: 340 KRRLKEEI---------ERRRAEA------AEKRQKMPEDGLSDDKKPFKCFTPKGSSLK 384
+ + +EI ++ RAEA AE+R+++ + DKK + + ++
Sbjct: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAE---QDKK----IADERARIE 296
Query: 385 IEERA---EFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 440
EE+A E + ++ ++ + A + + E+ +A E + + K AA +
Sbjct: 297 AEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355
Score = 33.5 bits (75), Expect = 0.50
Identities = 36/177 (20%), Positives = 77/177 (43%), Gaps = 39/177 (22%)
Query: 275 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR-EERRKVLEEEEQRRKQEEADRK 333
+++ RRR E +QK++E LE E + +R ++ + E +RR ++E R+
Sbjct: 1 MDDFERRR--------ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ 52
Query: 334 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 393
+EEE ++ +++E + +P++ T + ++ ++ A FL
Sbjct: 53 KQEEESLGQVTDQVE------VNAQNSVPDEEAKT--------TTTNTQVEGDDEAAFLE 98
Query: 394 KSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN 450
+ ++ + R ++ A+E K PT AS L +P+ ++N
Sbjct: 99 RLARRE---------------ERRQKRLQEALERQKEFDPTITDAS-LSLPSRRMQN 139
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 99.8 bits (247), Expect = 6e-21
Identities = 92/461 (19%), Positives = 203/461 (44%), Gaps = 64/461 (13%)
Query: 22 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQ 81
Q+ + E++ RE++ R+++LR++QEE Q+ + E + E + Q
Sbjct: 317 QQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ 376
Query: 82 VEGDDEAAFLERLARREERR---QKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAEN 138
+ + + ++L R ++ R Q R ++ L R+++ R +
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL--------------RREQQLRRE 422
Query: 139 ETTEKEEKSESRQERYEIEETETVTKSYQ--KNDW--------RDAEENKKEDKEKEEEE 188
+ +E++ E ++++E E E K Q + DW R +E +K+ ++++EE
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE 482
Query: 189 EEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 248
E + + + E + ++++ +++++ + E + +++ +K Q E + +E
Sbjct: 483 ERRERWLKLEEEERREQQERREQQLRREQEERREQR-----LKRQEEEERLQQRLRSEQQ 537
Query: 249 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGE-------TESEEFEKLKQKQQEAA 301
R + E ++E +R + L+R + E E E ++ +++QE
Sbjct: 538 LRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597
Query: 302 LELEELKKKREERRKVLEEEEQRRKQEEADRK-----LREEEEKRRLKEEIERRRAEAAE 356
LE + LK++ ER + E EQR K+EE + + L+ EE++ R ++++ R + E E
Sbjct: 598 LE-QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 357 KRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDS 416
+R K E+ ++E+R + ++ ++ + Q +I S
Sbjct: 657 QRLKREEE-----------------EERLEQRLKREHEEERREQELAEEEQEQARERIKS 699
Query: 417 RLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEK 457
R+ ++ +E A+ +K P EG R + EK
Sbjct: 700 RIPKWQWQLESEADARQSK--VYSRPRKQEGQRRRQEQEEK 738
Score = 97.8 bits (242), Expect = 2e-20
Identities = 101/409 (24%), Positives = 196/409 (47%), Gaps = 49/409 (11%)
Query: 23 RNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQV 82
R + EEE ++R RR +Q LR+KQEEE Q ++ E + +E + Q
Sbjct: 287 RRERQEEEQQQQRLRREQQ--LRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344
Query: 83 EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 142
E E+ RRE+ ++R Q+ Q+E RR Q E +
Sbjct: 345 ER------REQQLRREQEEERREQQLRREQEE-------------ERREQQLRREQQLRR 385
Query: 143 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
+++ +Q R E ++ + ++ R ++ ++E + + E+EEE+ ++ E +
Sbjct: 386 EQQLRREQQLRRE-QQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH--EQER 442
Query: 203 KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 262
+++++K++ +EE + ++ R++ E + E +LK + R + +E
Sbjct: 443 REQRLKRE---QEERRDWLKREE---ETERHEQERRKQQLKRDQEEERR---ERWLKLEE 493
Query: 263 AEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALEL-----EELKKKREERRKV 317
E Q E +R ++LRR E E ++LK++++E L+ ++L++++EERR+
Sbjct: 494 EERREQQE--RREQQLRR---EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 318 L--EEEEQRRKQEEADRKLREEEEKRR---LKEEIERRRAEAAEKRQKMPEDGLS-DDKK 371
L EEE+R +QE +++L+ E+E+RR LK E ERR+ ++++ E L ++ +
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608
Query: 372 PFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQ 420
+ + LK EE E + + KS + Q + + R EQ
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Score = 97.4 bits (241), Expect = 3e-20
Identities = 99/373 (26%), Positives = 174/373 (46%), Gaps = 44/373 (11%)
Query: 26 DDEEEAARERRRRARQERLRQKQEEESL--------------GQVTDQVEVNAQNSVPD- 70
++EE+ R R+RR R++ L+ +EEE L G DQ +Q D
Sbjct: 813 EEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872
Query: 71 ------EEAKTTTTNT-------QVEGDDEAAFL---ERLARREERRQKRLQEALERQKE 114
EE + +T Q + E L E +REER ++R QE + +E
Sbjct: 873 KWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE 932
Query: 115 FDPTITDASLSLPSRRMQNDTAENETT-EKEEKSESRQERYEIEETETVTKSYQKNDWRD 173
+ + L R + E E K++K + ++E+ EE E + ++ +R+
Sbjct: 933 EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE 992
Query: 174 AEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKE----PKEEVKSFMDRKKGFTE 229
EE ++E+++ EE EK +R K +++++++E + E + +R++ + E
Sbjct: 993 EEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE 1052
Query: 230 VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESE- 288
+ E +L E R KE E + E R E +RRR E E +
Sbjct: 1053 EEELQQE--EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110
Query: 289 -EFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEI 347
E E+L+Q++++ E E ++++E R+ EEEE Q+E ++ LREE EKRR ++E+
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYREEEE---VQQEEEQLLREEPEKRR-RQEL 1166
Query: 348 ERRRAEAAEKRQK 360
ER+ E E +Q+
Sbjct: 1167 ERQYREEEELQQE 1179
Score = 96.3 bits (238), Expect = 6e-20
Identities = 97/384 (25%), Positives = 184/384 (47%), Gaps = 45/384 (11%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
EE++ R R+R + + LR+++E + + Q E Q +P+EE K + E + E
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQRE---QRFLPEEEEKEQRRRQRREREKE 830
Query: 88 AAFLE---RLARREERRQKR-----LQEALERQKEFDPTITDA---SLSLPSRRMQNDT- 135
FLE +L RRE +Q + LQE ER++ + L +R ++
Sbjct: 831 LQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY 890
Query: 136 ---AENETTEKEEKS-ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEK 191
A E KE++ + +E + EE E + Q+ +R+ E+ ++E+++ EE EK
Sbjct: 891 AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK 950
Query: 192 PKRGSIGENQIKDEKIKKDKEP----KEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN 247
+R KD+K+++ +E + E + +R+K + E + E +L E
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE--EEQLLREER 1008
Query: 248 TFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESE--EFEKLKQKQQEAALELE 305
R K+ E + E R E +RR E E + E E+L+Q++++ E
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068
Query: 306 ELKKKRE-------------ERRKVLEEEEQRRKQEEADRKLREEEEKRR-----LKEEI 347
E ++++E E ++L EE ++R+++E +R+ REEEE ++ L+EE
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Query: 348 ERRRAEAAEKRQKMPEDGLSDDKK 371
E+RR + E++ + E+ ++++
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQ 1152
Score = 95.1 bits (235), Expect = 1e-19
Identities = 87/354 (24%), Positives = 165/354 (46%), Gaps = 45/354 (12%)
Query: 25 DDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV--EVNAQNSVPDEEAKTTTTNTQV 82
+++EE ER +R RQE+ RQ +EEE L Q +Q+ E + + E +
Sbjct: 908 EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Query: 83 EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 142
+ +++ E RR + R+K+ +E E Q+E + + + + + + + +
Sbjct: 968 QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ 1027
Query: 143 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
+EE+ R+ER + E ++ +R+ EE ++E+++ EE E +R +
Sbjct: 1028 QEEEQLLREEREKRRLQE------RERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Query: 203 KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 262
K+E++++++E +L E R R +E
Sbjct: 1082 KEEELQQEEE----------------------------QLLREEPEKRRRQERERQCREE 1113
Query: 263 AEGAPQVEAGKRLEELRRRRGETESE--EFEKLKQKQQEAALELEELKKKREERRKVLEE 320
E + E R E +RRR E E + E E+++Q++++ E E ++++E R+ EE
Sbjct: 1114 EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Query: 321 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK----MPEDGLSDDK 370
EE Q+E ++ LREE+EKRR + E + R E +++++ ED SD K
Sbjct: 1174 EEL---QQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224
Score = 93.6 bits (231), Expect = 4e-19
Identities = 95/381 (24%), Positives = 176/381 (46%), Gaps = 25/381 (6%)
Query: 27 DEEEAARER-RRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD 85
+EE+ RE +R RQER RQ +EEE L Q +Q+ + E+ + Q +
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER-----EKRRRQELERQYREE 1143
Query: 86 DEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE 145
+E E REE +KR ++ LERQ + + L + E E +EE
Sbjct: 1144 EEVQQEEEQLLREEP-EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202
Query: 146 KSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDE 205
+ RQ+R + E +S K W +EN D + + E + + ++Q++D
Sbjct: 1203 EELQRQKRKQRYRDED-QRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDR 1261
Query: 206 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEF-MTHKLKHTENTFSRPGGRASVDTKEAE 264
+ ++D + + DR++ + ++ F +L+ E ++ R S + K
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK--- 1318
Query: 265 GAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKK--------REERRK 316
Q+ +R E+ RR+ + + E E+L Q+++E L +E +K +E+ RK
Sbjct: 1319 ---QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 317 VLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCF 376
LEEE++ R+QE +RK +EE++ R +E E++ + +++ + E LS ++ K
Sbjct: 1376 FLEEEQRLRRQER-ERKFLKEEQQLRCQER-EQQLRQDRDRKFREEEQQLSRQERDRKFR 1433
Query: 377 TPKGSSLKIEERAEFLNKSVQ 397
+ + E +FL + Q
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQ 1454
Score = 92.4 bits (228), Expect = 9e-19
Identities = 106/428 (24%), Positives = 204/428 (47%), Gaps = 61/428 (14%)
Query: 18 QIAYQRND----DDEEEAARERRRRA--------RQERLRQKQEEESLGQVTDQVEVNAQ 65
Q++ Q D ++E++ R+ R R RQER R+ +EEE L Q ++ +++ Q
Sbjct: 1422 QLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQ 1481
Query: 66 NSVPDEEAKTTTTNTQVEGDD-EAAFLERLARREERRQKRLQEA--LERQKEFDPTITDA 122
+ + K Q+ + + F E+ R +E +K L+E L RQ+ + +
Sbjct: 1482 ----ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537
Query: 123 SLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN-KKED 181
R Q + + +EE+ + RQER E + +++ + +R E+ ++++
Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREEE-QLRQER----EEQQLSRQERDRKFRLEEQKVRRQE 1592
Query: 182 KEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPK-------EEVKSFMDRKKGFTEVKSQ- 233
+E++ E+E+ R G+ Q++ E+ +K +E + E+ +R + F E + Q
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQL 1652
Query: 234 NGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK-RLEELRRRRGETES----- 287
+ +L+H + R + + +E + Q K R EE + RR E E
Sbjct: 1653 RRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQE 1712
Query: 288 ------EEFEKLKQKQQEAALELEELKKKREER-RKVLEEE-------EQRRKQEEADRK 333
+E E+ +++++ E E+ + +R+ER RK+LEEE EQ+ +++E DRK
Sbjct: 1713 EQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRK 1772
Query: 334 LREEEEKRRLKEEIERRRAEAAEK-------RQKMPEDGLSDDKKPFKCFTPKGSSLKIE 386
REEE+ R+ +EE + R E+ K RQ+ E L ++ K + + L++E
Sbjct: 1773 FREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK-YRWEEEQLQLE 1831
Query: 387 ERAEFLNK 394
E+ + L +
Sbjct: 1832 EQEQRLRQ 1839
Score = 92.0 bits (227), Expect = 1e-18
Identities = 81/352 (23%), Positives = 160/352 (45%), Gaps = 38/352 (10%)
Query: 17 SQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTT 76
SQ+ +++ D + E++ R R++ R+ Q+ + P+EE
Sbjct: 1256 SQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRD--------------RHFPEEEQLER 1301
Query: 77 TTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 136
+ + D + E+ REER +KR ++ +R+ + + P RR + D
Sbjct: 1302 EEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRK 1361
Query: 137 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 196
E EE Q R +EE + + + ++ + E+ + + +++ +++ ++
Sbjct: 1362 FRE----EELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR 1417
Query: 197 IGENQI-KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 255
E Q+ + E+ +K +E +++V+ +R++ F E + Q + K + E
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRR-QERERKFLEEEQQLRQERHRKFREEEQLLQ----- 1471
Query: 256 ASVDTKEAEGAPQVEAGKRLEE---LRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 312
+ +E + Q K LEE LRR+ + + E E Q+ + LE E+ +++
Sbjct: 1472 ---EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528
Query: 313 ERRKVLEEEEQRRKQE-------EADRKLREEEEKRRLKEEIERRRAEAAEK 357
+RK L+EE+Q R+QE + DRK REEE+ R+ +EE + R E K
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRK 1580
Score = 90.9 bits (224), Expect = 3e-18
Identities = 96/360 (26%), Positives = 173/360 (48%), Gaps = 42/360 (11%)
Query: 35 RRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERL 94
+RRR QE R+++E E Q ++ Q +E+ + T Q E E
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEERAHRQQQE---EEQRRDFTWQWQAEEKSERGRQRLS 785
Query: 95 AR---REER-RQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETT--EKEEKSE 148
AR RE+R RQ R +E +R++ F P + RR Q E E E+EE+ +
Sbjct: 786 ARPPLREQRERQLRAEERQQREQRFLPEEEEKE----QRRRQRREREKELQFLEEEEQLQ 841
Query: 149 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEE-EEEEKPKRGSIGENQIKDEKI 207
R+ +++E E + Q+ R ++E +++ K + + EEE K +R ++ E++
Sbjct: 842 RRERAQQLQEEEDGLQEDQER--RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899
Query: 208 KKDK----EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG--------- 254
+K++ E +EE++ K+ E + Q E +L+ E R
Sbjct: 900 RKEQQLLQEEEEELQREEREKRRRQEQERQYRE--EEQLQQEEEQLLREEREKRRRQERE 957
Query: 255 RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 314
R K+ + + G+ E+ RR+ E + E E+L+Q++++ L+++RE+R
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL------LREEREKR 1011
Query: 315 RKVLEEEEQRRK---QEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 371
R+ E + R+K Q+E ++ LREE EKRRL+E + R E E+ Q+ E L ++++
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE--EELQQEEEQLLGEERE 1069
Score = 90.9 bits (224), Expect = 3e-18
Identities = 87/388 (22%), Positives = 181/388 (46%), Gaps = 35/388 (9%)
Query: 9 GRRSLAALSQIAYQRND-----DDEEEAARERRRRARQERLRQKQEEESLGQVTDQV--- 60
GR+ L ++ Q + ++++ +ER ++ RQ+R R+ +EEE Q++ Q
Sbjct: 1373 GRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ--QLSRQERDR 1430
Query: 61 ---EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLER---LARREER---RQKRLQEALER 111
E Q + E K Q+ + F E L REE+ RQ+R ++ LE
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490
Query: 112 QKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET--VTKSYQKN 169
+++ D R Q + E++ + RQ ++ EE + + Q+
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR 1550
Query: 170 DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKE--EVKSFMDRKKGF 227
RD + ++E +E EE++ ++ + +++++K+++ ++ ++ E + + R++G
Sbjct: 1551 QDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQ 1610
Query: 228 TEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETES 287
+++ + + + + R D K E PQ+ +R ++LR R
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFR 1670
Query: 288 EEFE--------KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 339
EE + +L++++++ EE + +R+ER + +EEQ+ +++E +RK REEE+
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQ 1730
Query: 340 KRRLKEEIERRRAE----AAEKRQKMPE 363
R+ E+ + RR E E+ Q PE
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPE 1758
Score = 90.1 bits (222), Expect = 4e-18
Identities = 77/342 (22%), Positives = 157/342 (45%), Gaps = 14/342 (4%)
Query: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVE-VNAQNSVPDEEAKTT 76
Q+ +R + R+R+ R ++++R++++E + Q+ Q + E +
Sbjct: 1562 QLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621
Query: 77 TTNTQVEGDDEAAFLERLARREERRQKRLQEA--LERQKEFDPTITDASLSLPSRRMQND 134
+ Q+ + E E+ R+ER +K L+E L RQ+ D
Sbjct: 1622 REDEQLLQERE----EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677
Query: 135 TAENETTEKEEKSES-RQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKE----EEEE 189
E + ++E+ R+E ++ E K Q+ +E +++ +E+E E E+
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ 1737
Query: 190 EKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTF 249
E+ +R +++E+++ ++E ++ + DRK E Q E + + ++ F
Sbjct: 1738 EQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKF 1797
Query: 250 SRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKK 309
R + + +E + PQ GK E + + E + + + + +Q A + +K
Sbjct: 1798 -REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEK 1856
Query: 310 KREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 351
R E +++ +EEEQ+R+QE +RKLREE +R+ KEE R+
Sbjct: 1857 SRREEQELWQEEEQKRRQER-ERKLREEHIRRQQKEEQRHRQ 1897
Score = 89.4 bits (220), Expect = 8e-18
Identities = 77/355 (21%), Positives = 178/355 (50%), Gaps = 23/355 (6%)
Query: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
Q+ ++ ++ E+ R ++ R+++LR++Q+ Q+ + ++ + + E+
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 422
Query: 78 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
+ E ++E +ERR++RL+ E ++++ + RR Q
Sbjct: 423 QQLRREQEEER---HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ---- 475
Query: 138 NETTEKEEKSESRQERY-EIEETETVTKSYQKNDW-RDAEENKKEDKEKEEEEEEKPKRG 195
K ++ E R+ER+ ++EE E + ++ R +E ++E + K +EEEE+ ++
Sbjct: 476 ----LKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531
Query: 196 SIGENQIK-DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG 254
E Q++ +++ ++++ K E + +++++ +K + E LK E +
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591
Query: 255 RASVDTKEA----EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKK 310
R + E E ++E +R E+ R +R E E E ++L + +++ ++L+++
Sbjct: 592 REQEERLEQRLKREEVERLEQEERREQ-RLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650
Query: 311 REERRKV-LEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK-RQKMPE 363
++ERR+ L+ EE+ + E+ R RE EE+RR +E E + +A E+ + ++P+
Sbjct: 651 QQERREQRLKREEEEERLEQ--RLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Score = 89.4 bits (220), Expect = 8e-18
Identities = 92/377 (24%), Positives = 171/377 (45%), Gaps = 65/377 (17%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
E++ RE++ R R+++LR++QEEE Q +Q E + Q E D
Sbjct: 410 EQQLRREQQLR-REQQLRREQEEERHEQKHEQ-----------ERREQRLKREQEERRD- 456
Query: 88 AAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETT-EKEEK 146
+L+R E Q+R ++ L+R +E + L RR Q + E + E+EE+
Sbjct: 457 --WLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER 514
Query: 147 SESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEK 206
E R +R E EE ++ R+ EE +++ ++EEE+ + +R ++++
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER--------REQR 566
Query: 207 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTE----NTFSRPGGRASVDTKE 262
+K+++E + + + ++ +K + E + +LK E R R + E
Sbjct: 567 LKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPE 626
Query: 263 AEGAPQVEAGKRLEELRRR--RGETESEEFEKLKQKQQEAALELEELKKKREERRKVLE- 319
E Q+ + EE R++ R E + ++LK++++E LE + LK++ EE R+ E
Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE-QRLKREHEEERREQEL 685
Query: 320 -EEEQR--------------------------------RKQEEADRKLREEEEKRRLKEE 346
EEEQ RKQE R+ +EE++RR + E
Sbjct: 686 AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745
Query: 347 IERRRAEAAEKRQKMPE 363
++ + E A ++Q+ E
Sbjct: 746 LQWQEEERAHRQQQEEE 762
Score = 89.4 bits (220), Expect = 8e-18
Identities = 101/393 (25%), Positives = 176/393 (44%), Gaps = 58/393 (14%)
Query: 27 DEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT----TNTQV 82
D+EE RER + +E R++QE +Q E Q EE + + Q+
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Query: 83 EGDDEAAFLERLARREERR--QKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENET 140
+ E + L R EE+R Q+R ++ L+R++E D L R Q +
Sbjct: 539 RREQEERREQLLKREEEKRLEQERREQRLKREQE---ERRDQLLKREEERRQ----QRLK 591
Query: 141 TEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGEN 200
E+EE+ E R +R E+E E + Q+ + EE +++ K EE+EE+ ++ E
Sbjct: 592 REQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQ 651
Query: 201 QIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSR-PGGRASVD 259
Q + E+ K +E +E ++ + R+ + + E + + E SR P + ++
Sbjct: 652 QERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR--ERIKSRIPKWQWQLE 709
Query: 260 TKEAEGAPQVEAGKRLEELRRRRGETES-----------EEFEKLKQKQQE--------- 299
++ +V + R +E +RRR E E +E E+ ++QQE
Sbjct: 710 SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTW 769
Query: 300 --AALELEELKKKREERRKVLEEEEQRR-----KQEEADRKLREEEEKRR---------- 342
A E E ++R R L E+ +R+ +Q+ R L EEEEK +
Sbjct: 770 QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK 829
Query: 343 ----LKEEIERRRAEAAEKRQKMPEDGLSDDKK 371
L+EE + +R E A++ Q+ EDGL +D++
Sbjct: 830 ELQFLEEEEQLQRRERAQQLQE-EEDGLQEDQE 861
Score = 89.4 bits (220), Expect = 8e-18
Identities = 93/369 (25%), Positives = 171/369 (46%), Gaps = 41/369 (11%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQ---VEG 84
E+E RE+R + ++E R +Q S Q+ + E + + EE K + ++
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569
Query: 85 DDEAAFLERLARREERRQKRL----QEALERQKEFDPTITDASLSLPSRRMQNDTAENET 140
+ E + L R EERRQ+RL +E LE++ + + +R++ + E E
Sbjct: 570 EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629
Query: 141 TEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGEN 200
++ KSE ++ER + + + ++ R+ EE + E + K E EEE+ ++ E
Sbjct: 630 RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE 689
Query: 201 QIKDEKIKKDKEPKEE--VKSFMDRK--KGFTEVKSQNG--------------------- 235
Q + + K + PK + ++S D + K ++ + Q G
Sbjct: 690 QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749
Query: 236 -EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK 294
E H+ + E + + K G ++ A L E R R + +EE ++ +
Sbjct: 750 EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRER--QLRAEERQQRE 807
Query: 295 QKQQEAALELEELKKKREERRK---VLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 351
Q+ E E+ +++R ER K LEEEEQ +++E A ++L+EEE+ L+E+ ERRR
Sbjct: 808 QRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA-QQLQEEEDG--LQEDQERRR 864
Query: 352 AEAAEKRQK 360
++ + QK
Sbjct: 865 SQEQRRDQK 873
Score = 89.0 bits (219), Expect = 1e-17
Identities = 86/390 (22%), Positives = 177/390 (45%), Gaps = 47/390 (12%)
Query: 18 QIAYQRNDDDEEEAARERRRRARQERLR---------QKQE----------EESLGQVTD 58
Q ++ D EE +RRR+ RQE+ R +KQE +E L +
Sbjct: 119 QRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQ 178
Query: 59 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF-------LERLARREERRQKRLQE--AL 109
+ + + +E+ ++ + E DE L R R E+++Q+R ++
Sbjct: 179 EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVF 238
Query: 110 ERQKEFDPTITDASLSLPSRRMQND--------TAENETTEKEEKSESRQERYEIEETET 161
+ ++E + + L ++Q + E E K E+ E R+ER E E+ +
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298
Query: 162 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKE----PKEEV 217
+ Q+ + EE +++ +E+ E++E + ++ E Q++ E+ ++ ++ +EE
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 218 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEE 277
+ ++ E + + +L+ + R + + + + +R ++
Sbjct: 359 RREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418
Query: 278 LRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRK---L 334
LRR + +E E+ +QK ++ E + LK+++EERR L+ EE+ + E+ RK
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERRE-QRLKREQEERRDWLKREEETERHEQERRKQQLK 477
Query: 335 REEEEKRR---LKEEIERRRAEAAEKRQKM 361
R++EE+RR LK E E RR + + Q++
Sbjct: 478 RDQEEERRERWLKLEEEERREQQERREQQL 507
Score = 88.6 bits (218), Expect = 1e-17
Identities = 94/393 (23%), Positives = 178/393 (45%), Gaps = 55/393 (13%)
Query: 28 EEEAAR--ERRRRARQERLRQKQEEESLGQVTDQV---EVNAQNSVPDEEAKTTTTNTQV 82
EE+ R ER R+ R+E LR +++ + ++ E + +++ + Q+
Sbjct: 1349 EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQL 1408
Query: 83 EGDDEAAFLE---RLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENE 139
D + F E +L+R+E R+ R +E R++E + + L R + E +
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468
Query: 140 TT-EKEEKSESRQERYE--IEETETVTKSYQKNDWRDAEENKKEDKEK--EEE------- 187
E+EE+ RQER +EE + + + + +R+ E +E + K EEE
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528
Query: 188 -------EEEKPKRGSIGENQIKD--------EKIKKDKEPKEEVKSFMDRKKGFTEVKS 232
EE++ +R G+ + +D E++++++E ++ + DRK E K
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKV 1588
Query: 233 QNGEFMTHKLKHTENTFSRPGGRASV----DTKEAEGAPQVEAGKRLEELRRRRGETESE 288
+ E K E R G+ + D K E ++ + + R+ R E
Sbjct: 1589 RRQE-QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647
Query: 289 EFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE--- 345
E +L+++++E L + +K REE + + E EEQ+ +++E DRK REEE++ R +E
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERER 1707
Query: 346 ------------EIERRRAEAAEKRQKMPEDGL 366
E+ER+ E + RQ+ ++ L
Sbjct: 1708 KFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740
Score = 87.4 bits (215), Expect = 3e-17
Identities = 99/398 (24%), Positives = 187/398 (46%), Gaps = 52/398 (13%)
Query: 26 DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD 85
++E+ ER +R RQE RQ +EEE + Q +Q+ +E + +
Sbjct: 1119 EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Query: 86 DEAAFL--ERLARREER-RQKRLQEALERQK----------------EFDPTITDASLSL 126
+E L E+ RR+ER RQ R +E L+RQK +++P +A +
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA---V 1235
Query: 127 PSRRMQNDTAENETTEKEEKSE--SRQERYEIE----ETETVTKSYQKNDWRDAEENKKE 180
++ ENE + E S+ RQ + +++ E + + ++ W+ + + E
Sbjct: 1236 RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE 1295
Query: 181 DKEKEEEEEEKPKRG---SIGENQI----KDEKIKK---DKEPKEEVKSFMDRKKGFTEV 230
+++ E EE+++ KR S E Q+ ++EK ++ D++ +EE + +R++
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRR 1355
Query: 231 KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 290
+ ++ +F +L+H E GR ++ ++ + E EE + R E E
Sbjct: 1356 QERDRKFREEELRHQEQ------GRKFLEEEQRLRRQERERKFLKEEQQLRCQERE---- 1405
Query: 291 EKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERR 350
++L+Q + E E+ ++E RK EEE+Q R+QE +RK EEE+ +L++E R+
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQER-ERKFLEEEQ--QLRQERHRK 1462
Query: 351 RAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER 388
E + Q+ E L ++ K F + L+ +ER
Sbjct: 1463 FREEEQLLQEREEQQLHRQERDRK-FLEEEQQLRRQER 1499
Score = 87.4 bits (215), Expect = 3e-17
Identities = 94/428 (21%), Positives = 185/428 (43%), Gaps = 60/428 (14%)
Query: 27 DEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS--------VPDEEAKTTTT 78
+EE+ RE + + RQER RQ +EEE L + + ++ P++E
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDN 1238
Query: 79 NTQVEGDDEAAF--LERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 136
+G + F LE R+ + Q+ LQ L Q+E D + +R ++
Sbjct: 1239 KVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERD---REQERRRWQQRDRHFPE 1295
Query: 137 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK-KEDKEKEEEEEEKPKRG 195
E + +E+K R++R EE + + + ++ R + K +E+++ +E EE+P R
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRR 1355
Query: 196 SIGENQIKDEKIKKDKEPK------------EEVKSFMDRKKGFT--EVKSQNGEFMTHK 241
+ + ++E+++ ++ + E + F+ ++ E + Q + K
Sbjct: 1356 QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415
Query: 242 LKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESE--EFEKLKQKQQE 299
+ E SR +E + Q K LEE ++ R E + E E+L Q+++E
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREE 1475
Query: 300 AALELEELKKK---------REER---------------RKVLEEEEQRRKQE------E 329
L +E +K R+ER RK LEEE+Q +Q+ +
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ 1535
Query: 330 ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERA 389
+++LR +E ++ +++ +R+ E + RQ+ E LS ++ K + + E+
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595
Query: 390 EFLNKSVQ 397
+F+ Q
Sbjct: 1596 KFMEDEQQ 1603
Score = 86.7 bits (213), Expect = 5e-17
Identities = 80/343 (23%), Positives = 160/343 (46%), Gaps = 25/343 (7%)
Query: 22 QRNDDDEEEAARERRRRARQERLR------QKQEEESLGQVTDQVEVNAQNSVPDEEAKT 75
Q +++ + RE+RRR QER Q++EE+ L + ++ + ++ K
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 76 TTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDT 135
Q+ G+ E RR + R+K+ +E E Q+E + + + + +
Sbjct: 967 QQKEEQLLGE------EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQY 1020
Query: 136 AENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG 195
+ + ++EE+ R+ER + E ++ +R+ EE ++E+++ EE E +R
Sbjct: 1021 RKKDELQQEEEQLLREEREKRRLQE------RERQYREEEELQQEEEQLLGEERETRRRQ 1074
Query: 196 SIGENQIKDEKIKKDKE----PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSR 251
+ K+E++++++E + E + +R++ E + E +L E R
Sbjct: 1075 ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE--EEQLLREEREKRR 1132
Query: 252 PGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR 311
+E E + E R E +RRR E E + E+ + +Q+E L EE +K+R
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 312 EERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEA 354
+ER + EEE+ ++Q+ R R+E+++ LK + E + A
Sbjct: 1193 QERERQYREEEELQRQKRKQR-YRDEDQRSDLKWQWEPEKENA 1234
Score = 85.9 bits (211), Expect = 8e-17
Identities = 80/341 (23%), Positives = 159/341 (46%), Gaps = 26/341 (7%)
Query: 22 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQ 81
+R +EEE +E + R+E+ +++QE E + ++++ + +E + + Q
Sbjct: 1167 ERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ 1226
Query: 82 VEGDDEAAFLER---LARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAEN 138
E + E A + RE + ++L+++ R ++ + +Q+ E
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ------------SQQDLQHLLGEQ 1274
Query: 139 ETTEKEEKSESRQER-YEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 197
+ ++E++ Q+R E E + + QK R ++++E + EE EEK +R
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Query: 198 GENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS 257
++E++ +++E + + DRK E++ Q K E R
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQE---QGRKFLEEEQRLR----RQE 1387
Query: 258 VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER-RK 316
+ K + Q+ +R ++LR+ R EE ++L +++++ EE + +R+ER RK
Sbjct: 1388 RERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERK 1447
Query: 317 VLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 357
LEEE+Q R +E RK REEE+ + +EE + R E K
Sbjct: 1448 FLEEEQQLR--QERHRKFREEEQLLQEREEQQLHRQERDRK 1486
Score = 85.5 bits (210), Expect = 1e-16
Identities = 94/417 (22%), Positives = 190/417 (45%), Gaps = 56/417 (13%)
Query: 26 DDEEEAARERRRRARQER--LRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE 83
++E++ +ER R+ R+E L++++E++ Q D+ + + + +E ++
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509
Query: 84 GDD-EAAFLE--RLARREERRQKRLQEA--LERQKEFDPTITDASLSLPSRRMQNDTAEN 138
+ E FLE + R++R++K LQE L RQ+ D R+ + + E
Sbjct: 1510 SQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD-----RKFREE--EQ 1562
Query: 139 ETTEKEEKSESRQER---YEIEETETVTKSYQKNDWRDAEENKKEDKEKE---------- 185
E+EE+ SRQER + +EE + + ++ D ++ ++++ +++
Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFR 1622
Query: 186 -------EEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFM 238
E EE++ R +++E + +E +++++ DRK E Q GE
Sbjct: 1623 EDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682
Query: 239 THKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR-------RGETESEEF- 290
+ + + F + +E + Q E R +EL R+ R ETE E+
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFL-QEEQQLRRQELERKFREEEQLRQETEQEQLR 1741
Query: 291 -----------EKLKQKQQEAALELEELKKK-REERRKVLEEEEQRRKQEEADRKLREEE 338
E+L+ +++E L +E +K REE + E EEQ+ + +E+DRK REEE
Sbjct: 1742 RQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEE 1801
Query: 339 EKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKS 395
+ R + E ++ R + + + + E+ L +++ + + + EE+ KS
Sbjct: 1802 QL-RQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS 1857
Score = 85.1 bits (209), Expect = 1e-16
Identities = 76/366 (20%), Positives = 171/366 (46%), Gaps = 48/366 (13%)
Query: 22 QRNDDDEEEAARERRRRARQERLRQK---QEEESLGQVTDQVEVNAQNSVPDEEAKTTTT 78
Q+ + E E A + +QERL Q+ + +E L + + + + +E+ ++
Sbjct: 139 QKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKG 198
Query: 79 NTQVEGDDEAAFLERLARRE--ERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 136
+ E DE E+L RRE E R+K +E ++++E
Sbjct: 199 HETEEFPDE----EQLRRRELLELRRKGREEKQQQRRE---------------------R 233
Query: 137 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN-------KKEDKEKEEEEE 189
++ ++EE+ E R+ + + E + + R+ +E ++++ +E +EE
Sbjct: 234 QDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE 293
Query: 190 EKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTE-----VKSQNGEFMTHKLKH 244
E+ ++ E Q++ ++ ++ +E +EE + +R++ E ++ + E +L+
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRR 353
Query: 245 TENTFSRPG--GRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAAL 302
+ R R + + + + + +R ++LRR + ++ + +Q ++E L
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413
Query: 303 ELEELKKKREERRKVLEEE--EQRRKQEEADRKLREEEEKRR--LKEEIERRRAEAAEKR 358
E+ ++ ++ R+ EEE EQ+ +QE +++L+ E+E+RR LK E E R E ++
Sbjct: 414 RREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRK 473
Query: 359 QKMPED 364
Q++ D
Sbjct: 474 QQLKRD 479
Score = 84.3 bits (207), Expect = 2e-16
Identities = 89/363 (24%), Positives = 172/363 (47%), Gaps = 49/363 (13%)
Query: 22 QRNDDDEEEAAR--ERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTN 79
QR EE+ R ER ++ RQ+R R+ +EEE L Q ++ +++ Q
Sbjct: 1530 QRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ-------------- 1575
Query: 80 TQVEGDDEAAFLERLARREERRQKRLQEALE-RQKEFDPTITDASLSLPSRRMQNDTAEN 138
E D + E+ RR+E+ +K +++ + R++E + R+ + D E
Sbjct: 1576 ---ERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER----DRKFRED--EQ 1626
Query: 139 ETTEKEEKSESRQERYE--IEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 196
E+EE+ RQER +EE + + ++ E+ + D++++ EEE+ +
Sbjct: 1627 LLQEREEQQLHRQERDRKFLEEEPQLRR-------QEREQQLRHDRDRKFREEEQLLQEG 1679
Query: 197 IGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKH-------TENTF 249
+ + E+ +K +E +++++ +K E + + + K + TE
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739
Query: 250 SRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKK 309
R R +E + P+ E ++LRR+ + + E E+L+Q+++E L +E +
Sbjct: 1740 LRRQERYRKILEEEQLRPEREE----QQLRRQERDRKFREEEQLRQEREEQQLRSQESDR 1795
Query: 310 K-REERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSD 368
K REE + E EEQ+ + ++ D K R EEE+ +L+E+ +R R E RQ E+ +
Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQE--RDRQYRAEEQFAT 1853
Query: 369 DKK 371
+K
Sbjct: 1854 QEK 1856
Score = 83.6 bits (205), Expect = 4e-16
Identities = 87/373 (23%), Positives = 171/373 (45%), Gaps = 38/373 (10%)
Query: 18 QIAYQRNDDDEEEAARERRRRARQERLRQK-----QEEESLGQVTDQVEVNAQNS----- 67
++ Q +++E + E+ R QE+ RQ+ +EEE L + + ++
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224
Query: 68 ---VPDEEAKTTTTNTQVEGDDEAAF--LERLARREERRQKRLQEALERQKEFDPTITDA 122
P++E +G + F LE R+ + Q+ LQ L Q+E D +
Sbjct: 1225 WQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERD---REQ 1281
Query: 123 SLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK-KED 181
+R ++ E + +E+K R++R EE + + + ++ R + K +E+
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE 1341
Query: 182 KEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHK 241
++ +E EE+P R + + ++E+++ ++ ++ ++ ++ E K E +
Sbjct: 1342 EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEE-QQLR 1400
Query: 242 LKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETES---EEFEKLKQKQQ 298
+ E + R + ++ + + R EE + RR E E EE ++L+Q++
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460
Query: 299 EAALELEELKKKREER--------RKVLEEEEQRRKQEEADRKLREEE------EKRRLK 344
E E+L ++REE+ RK LEEE+Q R+QE DRK RE+E E++ L+
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQER-DRKFREQELRSQEPERKFLE 1519
Query: 345 EEIERRRAEAAEK 357
EE + R + K
Sbjct: 1520 EEQQLHRQQRQRK 1532
Score = 82.4 bits (202), Expect = 9e-16
Identities = 77/299 (25%), Positives = 142/299 (47%), Gaps = 40/299 (13%)
Query: 96 RREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYE 155
RR+E Q+R E +RQ E +P RR + E E E EE+SE +QER E
Sbjct: 113 RRQEEDQRRF-EPRDRQLEEEPG--------QRRRQKRQEQERELAEGEEQSE-KQERLE 162
Query: 156 IEETETVTKSY--QKNDWRDAEENKKEDKE----KEEEEEEKPKRGSIGENQIKDEKIKK 209
+ + + Q+ +W++ EE + E+++ K E EE P + ++ + + K
Sbjct: 163 QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222
Query: 210 DKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV 269
+E +++ + DR F E + + L+ E + + +E E
Sbjct: 223 REEKQQQRRERQDRV--FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE----- 275
Query: 270 EAGKRLE--ELRRRRGETESEEF-----EKLKQKQQEAALELEELKKKREERRKVLEE-- 320
E ++LE ELRR R E E ++ ++L++KQ+E E +E +++++ERR+ EE
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 321 --------EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 371
EE+R +Q +++ E++ R ++E ERR + ++Q E L +++
Sbjct: 336 EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Score = 77.8 bits (190), Expect = 2e-14
Identities = 75/325 (23%), Positives = 152/325 (46%), Gaps = 30/325 (9%)
Query: 25 DDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEG 84
+D+++ +E +++ RQER R+ +E+E L Q ++ +++ Q E
Sbjct: 1599 EDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ-----------------ER 1641
Query: 85 DDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKE 144
D + E RR+ER Q+ L+ +R+ + + RR + D E E++
Sbjct: 1642 DRKFLEEEPQLRRQEREQQ-LRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE--EEQ 1698
Query: 145 EKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD 204
+ +ER ++E + + + + +R+ EE +++ E+E+ ++ R + E Q++
Sbjct: 1699 QLRRQERERKFLQEEQQLRRQELERKFRE-EEQLRQETEQEQLRRQERYRKILEEEQLRP 1757
Query: 205 EKIK-------KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL--KHTENTFSRPGGR 255
E+ + +D++ +EE + +R++ + + +F + + E RP R
Sbjct: 1758 EREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQR 1817
Query: 256 ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR 315
E E E +RL + R R+ E + + K +++E L EE +K+R+ER
Sbjct: 1818 DGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERE 1877
Query: 316 KVLEEEEQRRKQEEADRKLREEEEK 340
+ L EE RR+Q+E R + E K
Sbjct: 1878 RKLREEHIRRQQKEEQRHRQVGEIK 1902
Score = 65.1 bits (157), Expect = 2e-10
Identities = 59/239 (24%), Positives = 118/239 (49%), Gaps = 20/239 (8%)
Query: 142 EKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE----NKKEDKEKE------EEEEEK 191
EK + + ++ + E + ++ D + EE +++ +E+E EE+ EK
Sbjct: 98 EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEK 157
Query: 192 PKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFM--THKLKHTENTF 249
+R + Q +DE++ + ++ +E + ++ K E +L+ E
Sbjct: 158 QERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLE 217
Query: 250 SRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK----QKQQEAALELE 305
R GR + E +V + +E R+R EE EKL+ Q+Q+E E E
Sbjct: 218 LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEE-EKLQEEEPQRQRELQEEEE 276
Query: 306 ELKK-KREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 363
+L+K +R+E R+ +EEEQ++++ +++LR ++E+ R +++ ERR E E+R++ E
Sbjct: 277 QLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR--EQQERREQQEE 333
Score = 53.1 bits (126), Expect = 6e-07
Identities = 44/181 (24%), Positives = 89/181 (49%), Gaps = 19/181 (10%)
Query: 205 EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAE 264
E + +D+ +E+ + F R + +++ + G+ K + E + +++ E
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDR---QLEEEPGQRRRQKRQEQERELAE----GEEQSEKQE 159
Query: 265 GAPQVEAGKRLEELRRRRGE--------TESEEFEKLKQKQQEAALELEELKKKR--EER 314
Q + +R EEL R+R E E E+ + K + E + E+L+++ E R
Sbjct: 160 RLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELR 219
Query: 315 RKVLEEEEQRRKQEEADRKLREEEEKR-RLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 373
RK EE++Q+R+ E DR +EEEEK R +E + R+ E ++ + + L ++++
Sbjct: 220 RKGREEKQQQRR-ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL 278
Query: 374 K 374
+
Sbjct: 279 R 279
Score = 45.1 bits (105), Expect = 2e-04
Identities = 40/155 (25%), Positives = 77/155 (49%), Gaps = 14/155 (9%)
Query: 278 LRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE---EADRKL 334
L+ RR E + FE + +Q E +K++E+ R++ E EEQ KQE + DR+
Sbjct: 110 LQDRRQEEDQRRFEP-RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168
Query: 335 REEEEKRRLKE--EIERRRAEAAE-------KRQKMPEDGLSDDKKPFKCFTPKGSSLKI 385
R+EE R+ +E E E RRAE + + ++ P++ ++ + KG K
Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLE-LRRKGREEKQ 227
Query: 386 EERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQ 420
++R E ++ Q+ + + ++ K + +L++
Sbjct: 228 QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE 262
Score = 39.7 bits (91), Expect = 0.007
Identities = 36/129 (27%), Positives = 63/129 (48%), Gaps = 22/129 (17%)
Query: 255 RASVDTKEA--EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 312
RA D KE+ + Q E +R E R + E E ++ +QK+QE EL E +++ E
Sbjct: 100 RARCDGKESLLQDRRQEEDQRRFEPRDR---QLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 313 ERRKVLEEEEQ-------RRKQEEADRKLREEEEKR----------RLKEEIERRRAEAA 355
++ ++ + + Q R++QE +R+ R EE++ +E + RR E
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216
Query: 356 EKRQKMPED 364
E R+K E+
Sbjct: 217 ELRRKGREE 225
Score = 29.3 bits (64), Expect = 9.4
Identities = 20/71 (28%), Positives = 40/71 (56%), Gaps = 5/71 (7%)
Query: 301 ALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 360
A L+E K+ R + ++ L ++ R+QEE R+ E R+L+EE +RR + +++++
Sbjct: 92 ATGLDEEKRARCDGKESLLQD---RRQEEDQRRF--EPRDRQLEEEPGQRRRQKRQEQER 146
Query: 361 MPEDGLSDDKK 371
+G +K
Sbjct: 147 ELAEGEEQSEK 157
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 93.2 bits (230), Expect = 5e-19
Identities = 78/359 (21%), Positives = 160/359 (44%), Gaps = 25/359 (6%)
Query: 3 GGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 62
G S RR L A++ D D+ E R++ R R+E+ + ++E + + + +
Sbjct: 32 GSQESPRRRGLGQ----AHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDR 87
Query: 63 NAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDA 122
+ + E + + + D E +R +E RQK + ER+ E
Sbjct: 88 HRKRDRHRERQRDREKERERQTDRER---DRQREKERNRQKERERETEREGE-------- 136
Query: 123 SLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDK 182
R T E++ +E +ER E + T+ ++ + R+ E+N++E +
Sbjct: 137 ------RGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKE-REREKNRQERR 189
Query: 183 EKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL 242
E+E + E++ K + ++ + +++ E + E K DR++ + E +
Sbjct: 190 ERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERE 249
Query: 243 KHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAAL 302
+ +E R R ++ + + + +R + +R+R E E+ +++Q+E
Sbjct: 250 RASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERER 309
Query: 303 ELEELKKKREERRKVLEEEEQRRKQEEADR-KLREEEEKRRLKEEIERRRAEAAEKRQK 360
E E +K+ ER + E E +R+++ E DR K RE + KR+ + + ER R E R++
Sbjct: 310 ERERNRKRERERER--ERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQ 366
Score = 90.9 bits (224), Expect = 3e-18
Identities = 99/460 (21%), Positives = 189/460 (41%), Gaps = 49/460 (10%)
Query: 22 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD-QVEVNAQNSVPDEEAKTTTTNT 80
Q + + + + +ER R+ +ER +++ E + TD Q E Q E + T
Sbjct: 108 QTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRER 167
Query: 81 QVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENET 140
Q + ER ++E R+K QE ER+++ E E
Sbjct: 168 QRQ-------TERNRQKEREREKNRQERRERERQ---------------------REKEN 199
Query: 141 TEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGEN 200
++ SE +ER ETET T+ ++ D R+ + +K ++E+E++ E +
Sbjct: 200 KTEDRHSERGRERERERETETETERKRQTD-RERDRQRKTEREREKQAERE--------- 249
Query: 201 QIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 260
+ + + ++DKE + E DR + E + Q + + T R R
Sbjct: 250 RASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRET-ERKRERQRERE 308
Query: 261 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 320
+E E + E + E R R+ ETE + EK ++++++ E++ + ++ R +
Sbjct: 309 RERERNRKRERERERERERERQRETERDR-EKERERKRKRQTEMDRERNRQTGREGRRQA 367
Query: 321 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 380
E +R ++ E DR+ E E+R + + +R R + E++ + DG + +K + +
Sbjct: 368 ERERERERERDRQSAREREER--ERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRE 425
Query: 381 SSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 440
S ER + +K G + + + + ++ T + + SD
Sbjct: 426 S-----ERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSD 480
Query: 441 LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVG 480
P G+R KS E S+ G P K + G G
Sbjct: 481 PNRPTRGIR-WKSSPEDPKAASTRFPWGRPAKASRGRVAG 519
Score = 43.1 bits (100), Expect = 6e-04
Identities = 25/95 (26%), Positives = 53/95 (55%), Gaps = 7/95 (7%)
Query: 276 EELRRRRG------ETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 329
+E RRRG + + ++ E+ +QK++E E + +++ + +R+ E+++ RK++
Sbjct: 34 QESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR 93
Query: 330 ADRKLREEEEKRRLKEEIER-RRAEAAEKRQKMPE 363
+ R+ E++R + + ER R+ E RQK E
Sbjct: 94 HRERQRDREKERERQTDRERDRQREKERNRQKERE 128
Score = 41.6 bits (96), Expect = 0.002
Identities = 33/113 (29%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 260 TKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLE 319
T + G VE L+ RRR G ES L Q ++A + E +++E R+
Sbjct: 9 TADQLGTLWVEVTIPLDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERR--- 65
Query: 320 EEEQRRKQEEADRKL-REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 371
E+R+ + E DRK R E+ R K + R R EK ++ D D ++
Sbjct: 66 -REKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQR 117
Score = 41.6 bits (96), Expect = 0.002
Identities = 19/91 (20%), Positives = 46/91 (50%)
Query: 273 KRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADR 332
+R ++ R+R + ++ K+++++ E + ++K R+K E E +R + DR
Sbjct: 82 RREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDR 141
Query: 333 KLREEEEKRRLKEEIERRRAEAAEKRQKMPE 363
+ + E+ R ++ + R + +RQ+ E
Sbjct: 142 QTDGQRERERQRDAEKERERQTDRERQRQTE 172
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 92.4 bits (228), Expect = 9e-19
Identities = 85/400 (21%), Positives = 186/400 (46%), Gaps = 35/400 (8%)
Query: 22 QRNDDDEEEAARERRRRARQERLRQKQEE-ESLGQVTDQVE-VNAQNSVPDEEAKTTTTN 79
Q + +++ +E R + ERLR+K+E ++ +QVE + + + ++E KT
Sbjct: 384 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE 443
Query: 80 TQVEGDDEAAFLERLARREERRQKRLQEALERQKE--FDPTITDASLSLPSRRMQNDTAE 137
+++ ++ E+ R EE + +E +++Q+E ++ + + + +
Sbjct: 444 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 503
Query: 138 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE--------- 188
+ E+EEK ++E+ +E +K WR + ++ED+ E+EE
Sbjct: 504 EKMQEQEEKIWEQEEKIRDQEEMW---GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 560
Query: 189 -----------EEKPKRGSIGENQIKDEKIKKDKEPK--EEVKSFMDRKKGFTEVKSQNG 235
+E+ K+ E ++++E+ +++E K EE + ++++ E + +
Sbjct: 561 WDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQ 620
Query: 236 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ 295
E + E + + K E ++ +RL E + + E E + ++ Q
Sbjct: 621 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
Query: 296 KQQEAALELEELKKKREERRKVLEEEEQRRKQE---EADRKLREEEEKRRLKEEIERRRA 352
+Q+E E E+++KK +E+ K ++E+ R++E E ++K+REEEE R +EE +
Sbjct: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEE---KMQ 737
Query: 353 EAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFL 392
E EK Q+ E+ ++K ++ ++ E+ E L
Sbjct: 738 EQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKL 777
Score = 90.5 bits (223), Expect = 3e-18
Identities = 92/368 (25%), Positives = 170/368 (46%), Gaps = 39/368 (10%)
Query: 26 DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQ-NSVPDEEAKTTTTNTQVEG 84
+ EE+ R+ +R QE+ ++QE+E + +Q E+ Q + ++E K ++
Sbjct: 311 EQEEKMWRQEKRLREQEKELREQEKE----LREQKELREQEEQMQEQEEKMWEQEEKMRE 366
Query: 85 DDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQND---------- 134
+E + + E+ +Q R QE R +E D L RM+
Sbjct: 367 QEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKM 426
Query: 135 TAENETTEKEEKSESRQERYEIEE----------TETVTKSYQKNDWRDAEENKKEDKEK 184
E + E+E+K+ ++E+ + EE E T Q+ + EEN E +EK
Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 486
Query: 185 EEEE----EEKPKRGSIGENQIKDEKI-KKDKEPKEEVKSFMDRKKGFTEVKSQNGE--- 236
E ++ E+K K + Q ++EKI +++++ +++ + + KK + + K + E
Sbjct: 487 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 546
Query: 237 -FMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ 295
K++ E R T+E E + K EE R R E + E E++ +
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606
Query: 296 KQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 355
+Q+E E EE K +E+ K+ E+EE+ ++QEE K+ E+EEK +EE +
Sbjct: 607 EQEEKMQEQEE--KMQEQEEKMWEQEEKMQEQEE---KMWEQEEKMWEQEEKMWEQQRLP 661
Query: 356 EKRQKMPE 363
E+++K+ E
Sbjct: 662 EQKEKLWE 669
Score = 83.2 bits (204), Expect = 5e-16
Identities = 76/340 (22%), Positives = 158/340 (46%), Gaps = 23/340 (6%)
Query: 32 ARERRRRARQERLRQKQEEESLGQVTDQVEVNA----QNSVPDEEAKTTTTNTQVEGDDE 87
A E +R R K+ + + ++T + + + +N++ +EE K Q ++
Sbjct: 178 AGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQ----EK 233
Query: 88 AAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKS 147
E + K L+ LER K P + +L R + + E E ++++
Sbjct: 234 LPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
Query: 148 ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGEN----QIK 203
+ ++ + E E + ++ WR + ++++KE E+E+E ++ + E Q +
Sbjct: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQ 353
Query: 204 DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEA 263
+EK+ + +E E + M R++ + + K++ E R +E
Sbjct: 354 EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL----REK 409
Query: 264 EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQ 323
E + E K E++ + R E + +E EK + Q+E +++E ++ RE +K+ EEEE
Sbjct: 410 EERMR-EQEKMWEQVEKMREEKKMQEQEKKTRDQEE---KMQEEERIREREKKMREEEET 465
Query: 324 RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 363
R+QEE K++++EE +EE E ++ E+++K+ E
Sbjct: 466 MREQEE---KMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502
Score = 81.3 bits (199), Expect = 2e-15
Identities = 85/370 (22%), Positives = 166/370 (44%), Gaps = 29/370 (7%)
Query: 22 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQ----VTDQVEVN-AQNSVPDEEAKTT 76
Q EEE RER ++ R+E +++EE + + + +Q E Q +P+++ K
Sbjct: 442 QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW 501
Query: 77 TTNTQVEGDDEAAFLERLARREER---------RQKRLQEALERQKEFDPTITDASLSLP 127
E +++ E R +E RQ++++E ++ E + + D +
Sbjct: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
Query: 128 SRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WRDAEENKKEDKEK 184
Q + E +T E+E+K+ ++E+ EE + + + R+ EE +E +EK
Sbjct: 562 D---QEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEK 618
Query: 185 EEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKH 244
+E+EEK + Q ++EK+ + +E E + M ++ E K + E K++
Sbjct: 619 MQEQEEKMWEQE-EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH--EKMQE 675
Query: 245 TENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALEL 304
E + + +E E K+ + + R E E EK ++++E E
Sbjct: 676 QEKMQEQ---EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQ 732
Query: 305 EELKKKREERRKVLEEE--EQRRKQEEADRKLREEEEKRRLKEEI-ERRRAEAAEKRQKM 361
EE +++EE+ + EEE EQ K E + K+ E++ KE++ E + + EK +
Sbjct: 733 EEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQ 792
Query: 362 PEDGLSDDKK 371
E ++K
Sbjct: 793 EEKMRDQEEK 802
Score = 81.3 bits (199), Expect = 2e-15
Identities = 78/337 (23%), Positives = 157/337 (46%), Gaps = 43/337 (12%)
Query: 26 DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD 85
D EE+ E R R R++++R+ EEE + + ++++ + + ++E K +++
Sbjct: 580 DQEEKMREEERMREREKKMRE--EEEMMREQEEKMQ-EQEEKMQEQEEKMWEQEEKMQEQ 636
Query: 86 DEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE 145
+E + + E+ + Q+ L QKE E+E +++E
Sbjct: 637 EEKMWEQEEKMWEQEEKMWEQQRLPEQKE-------------------KLWEHEKMQEQE 677
Query: 146 KSESRQER-YEIEETETVTKSYQKNDW---RDAEENKKEDKEKEEEEEEKPKRGSIGENQ 201
K + ++E+ +E E+ E T+ +K W + EE ++EK+ EEE+ R + Q
Sbjct: 678 KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQ 737
Query: 202 IKDEKIKKDKEP--KEEVKSFMDRKKGFTEVK--SQNGEFMTH-KLKHTENTFSRPGGRA 256
++EK+++ +E ++E K + +K + + + Q + H K++ E + +
Sbjct: 738 EQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQ----- 792
Query: 257 SVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRK 316
E + Q E + EE + RG+ E ++ K QE + +E K +E +
Sbjct: 793 -----EEKMRDQEEKMRGQEE--KMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKM 845
Query: 317 VLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE 353
+EE+ K + + K+RE+EEK R +EE R + E
Sbjct: 846 WGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882
Score = 72.8 bits (177), Expect = 7e-13
Identities = 77/359 (21%), Positives = 160/359 (44%), Gaps = 13/359 (3%)
Query: 27 DEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDD 86
D+EE + ++ RQE++R+ +E+ + + +++ Q EE T Q +
Sbjct: 522 DQEEMWGQEKKMWRQEKMRE--QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTW 579
Query: 87 EAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEK 146
+ R R R+K+++E E +E + + + + + + E + E+EEK
Sbjct: 580 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEK 639
Query: 147 SESRQER-YEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDE 205
++E+ +E EE + + + E K +++EK +E+EEK E + +++
Sbjct: 640 MWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQ 699
Query: 206 KIKK-DKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAE 264
+ K D+E E +S +R+K E + E + E + + K E
Sbjct: 700 EKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWE 759
Query: 265 GAPQVEAGKRLEELRRRRGETES-EEFEKL-----KQKQQEAALELEELKKK-REERRKV 317
++ +RL E + + E E +E EK+ K + QE + +E K + +EE+ +
Sbjct: 760 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRG 819
Query: 318 LEEE--EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 374
EE+ Q K + K+ +EEK +EE + + E++ + E+ + ++ +
Sbjct: 820 QEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMR 878
Score = 67.4 bits (163), Expect = 3e-11
Identities = 69/280 (24%), Positives = 137/280 (48%), Gaps = 30/280 (10%)
Query: 98 EERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDT--AENETTE-----KEEKSESR 150
EE ++R +LE + TIT+ L + +Q AE+E +E KE K +
Sbjct: 200 EELTKERDALSLELYRN---TITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLE 256
Query: 151 QERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEE-----EKPKRGSIGENQIKDE 205
+ ++ + + +T T Q+ WR EE ++++K+ ++EE E+ R G+ + ++E
Sbjct: 257 RAKFLLPQVQTNT--LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEE 314
Query: 206 KI-KKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAE 264
K+ +++K +E+ K +++K E K +L+ E + +E +
Sbjct: 315 KMWRQEKRLREQEKELREQEKELREQK---------ELREQEEQMQEQ--EEKMWEQEEK 363
Query: 265 GAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQR 324
Q E R EE R E + E E+ + Q+E E +E +++EER + E+ ++
Sbjct: 364 MREQEEKMWRQEE-RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 422
Query: 325 RKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 364
++ ++K++E+E+K R +EE + E+ +KM E+
Sbjct: 423 VEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462
Score = 57.4 bits (137), Expect = 3e-08
Identities = 54/211 (25%), Positives = 104/211 (49%), Gaps = 21/211 (9%)
Query: 177 NKKEDKEKEEEEEEKPKRG-SIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEV----- 230
+KK D+ EE +E+ + N I +E++KK +E + +K ++
Sbjct: 192 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKEL 251
Query: 231 --KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK---RLEELRRRRGET 285
K + +F+ +++ NT R + +E E + + K + E LR + G+
Sbjct: 252 KRKLERAKFLLPQVQ--TNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM 309
Query: 286 ESEEFEKLKQKQQ--EAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRL 343
+E + +Q+++ E EL E +K+ E++++ E+EEQ ++QEE K+ E+EEK R
Sbjct: 310 REQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE---KMWEQEEKMRE 366
Query: 344 KEEIERRRAE---AAEKRQKMPEDGLSDDKK 371
+EE R+ E EK+ + E + D ++
Sbjct: 367 QEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Score = 52.0 bits (123), Expect = 1e-06
Identities = 65/293 (22%), Positives = 129/293 (44%), Gaps = 45/293 (15%)
Query: 102 QKRLQEALERQKEFDPTITDASLSLP--SRRMQNDTAENETTEKEEKSESRQERYEIEET 159
Q+ L R K+ D I + + S + +T NE E ++K+ QE+ + E+
Sbjct: 182 QRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNE--ELKKKNAELQEKLPLAES 239
Query: 160 ETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKS 219
E + + N KE K K E K + N +++E ++++E +E+ K
Sbjct: 240 EK----------SEIQLNVKELKRKLERA--KFLLPQVQTNTLQEEMWRQEEELREQEKK 287
Query: 220 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 279
+++ + + E K++ E R KRL E
Sbjct: 288 IRKQEEKMWRQEERLRE-QEGKMREQEEKMWRQE-------------------KRLREQE 327
Query: 280 RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE----EADRKLR 335
+ E E E E+ + ++QE ++ +E +K E+ K+ E+EE+ +QE E ++++R
Sbjct: 328 KELREQEKELREQKELREQEEQMQEQE-EKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 386
Query: 336 EEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER 388
E+E+K R +EE R ++R + E+ + + +K ++ K++E+
Sbjct: 387 EQEQKMRDQEE----RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 92.4 bits (228), Expect = 9e-19
Identities = 92/402 (22%), Positives = 180/402 (44%), Gaps = 36/402 (8%)
Query: 27 DEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDD 86
++EE E+ + R++ + ++EE L + Q+ Q EE E ++
Sbjct: 314 EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEE 373
Query: 87 EAAFLERLARREERRQK--RLQEALERQKEFDPTITDASLSLPSR------------RMQ 132
E++ +EE+ Q+ R++E ++ +E + T+ + + + + Q
Sbjct: 374 RMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 433
Query: 133 NDTAENETTEKEEKSESRQER-YEIEET---ETVTKSYQKNDWRDAEENKKEDKEKEEEE 188
+ E ++EK + ++E+ +E EE + +K WR + ++ED+ E+EE
Sbjct: 434 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 493
Query: 189 EEKPKRGSIGENQIK----DEKIK-KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 243
+ + + + + + + DE+++ K++ +E+ K + +K E K+Q E T +
Sbjct: 494 KMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQE 553
Query: 244 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 303
R R +E E + E + +E + R E + E E+ Q+Q+E E
Sbjct: 554 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE 613
Query: 304 LEELKKKREERRKVLEEE----EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQ 359
EE ++EE K+ E+E EQ K +E + K+ E+EEK R +EE + E EK Q
Sbjct: 614 QEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEE---KMREQEEKMQ 670
Query: 360 KMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSG 401
E ++K +G K+ E+ E + +K G
Sbjct: 671 GQEEKMREQEEK------MQGQEEKMREQEEKMRGQEEKMWG 706
Score = 91.7 bits (226), Expect = 2e-18
Identities = 96/385 (24%), Positives = 180/385 (46%), Gaps = 29/385 (7%)
Query: 26 DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS-VPDEEAKTTTTNTQVEG 84
+ EE+ R+ +R QE+ ++QE+E + +Q ++ Q + ++E K ++
Sbjct: 273 EQEEKMRRQEKRLREQEKELREQEKE----LREQKKLREQEEQMQEQEEKMWEQEEKMRE 328
Query: 85 DDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKE 144
+E + + E+ +Q R QE R +E D L RM+ E EK
Sbjct: 329 QEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKM 388
Query: 145 EKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE----EEKPKRGSIGEN 200
++ E +ER + E T Q+ + EEN E +EKE ++ E+K K +
Sbjct: 389 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM 448
Query: 201 QIKDEKIKKDKE---PKEEV---KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG 254
Q ++EKI + +E +EE+ + M R++ E + Q E + + +
Sbjct: 449 QEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 508
Query: 255 RASVDTKEAEGAPQVEAGKRL-EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE 313
D + E ++ K++ ++ + R E +++E EK Q+E ++ E ++ RE
Sbjct: 509 MWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEE---KMREEERMRER 565
Query: 314 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 373
+K+ EEEE R+QEE K++E+EEK R +EE + E EK Q+ E ++K +
Sbjct: 566 EKKMREEEEMMREQEE---KMQEQEEKMREQEE---KMWEQEEKMQEQEEKMWEQEEKMW 619
Query: 374 KCFTPKGSSLKIEERAEFLNKSVQK 398
+ + K++E+ E + + +K
Sbjct: 620 E----QEEEDKMQEQEEMMWEQEEK 640
Score = 84.0 bits (206), Expect = 3e-16
Identities = 80/365 (21%), Positives = 169/365 (46%), Gaps = 31/365 (8%)
Query: 22 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQ----VTDQVEVN-AQNSVPDEEAKTT 76
Q EEE RER ++ R+E +++EE + + + +Q E Q +P+++ K
Sbjct: 384 QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW 443
Query: 77 TTNTQVEGDDEAAFLERLARREER---------RQKRLQEALERQKEFDPTITDASLSLP 127
E +++ E R +E RQ++++E ++ E + + D +
Sbjct: 444 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 503
Query: 128 SRRMQNDTAENETTEKEEKSESRQERYEIEET---ETVTKSYQKNDWRDAEENKKEDKEK 184
+ + + EKEE+ +++ ++ EE E T+ +K W E+ ++E++ +
Sbjct: 504 DQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMR 563
Query: 185 EEE----EEEKPKRGSIGENQIKDEKIKKDKEP--KEEVKSFMDRKKGFTEVKSQNGEFM 238
E E EEE+ R + Q ++EK+++ +E ++E K +K + + + +
Sbjct: 564 EREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 623
Query: 239 THKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQ 298
K++ E + +E E + K E+ + R + E + ++ K ++Q
Sbjct: 624 EDKMQEQEEMMWEQEEKM----QEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQ 679
Query: 299 EAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKR 358
E ++ +E +K RE+ K+ +EE+ QEE K+ +EEK +EE+ + +++
Sbjct: 680 EEKMQGQE-EKMREQEEKMRGQEEKMWGQEE---KMWGQEEKMWGQEEMREKEERIRDQK 735
Query: 359 QKMPE 363
+KM E
Sbjct: 736 EKMQE 740
Score = 78.2 bits (191), Expect = 2e-14
Identities = 77/362 (21%), Positives = 170/362 (46%), Gaps = 48/362 (13%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
+EE RE+ + R++ + +++E+ L + + E+ Q E+ K Q++ +E
Sbjct: 260 QEERLREQEGKMREQEEKMRRQEKRLRE--QEKELREQEKELREQKKLREQEEQMQEQEE 317
Query: 88 AAFLERLARREE-----RRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 142
+ + RE+ R+++RL E ++ +E + + D R + D E
Sbjct: 318 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQE----ERMWEQD---ERLRE 370
Query: 143 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
KEE+ +++ +E EE + EE + ++EK+ EEE+ R + Q
Sbjct: 371 KEERMREQEKMWEQEE-------------KMQEEERIREREKKMREEEETMREQEEKMQK 417
Query: 203 KDEKIKKDKEPKEEVKSFMDRK-KGFTEVKSQNGE----FMTHKLKHTENTFSRPGGRAS 257
++E + + +E + + + ++K K + + K Q E K++ E + +
Sbjct: 418 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 477
Query: 258 VDTKEAEGAPQVEAGKRLEELRRRRGETES---EEFEKLKQKQQ---------EAALELE 305
+ + E +++ + ++ + E E+ E+L++K++ + ++
Sbjct: 478 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMR 537
Query: 306 ELKKKREERRKVLEEEEQRRKQE---EADRKLREEEEKRRLKEE-IERRRAEAAEKRQKM 361
E KK +E+ +K ++EE+ R++E E ++K+REEEE R +EE ++ + + E+ +KM
Sbjct: 538 EEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKM 597
Query: 362 PE 363
E
Sbjct: 598 WE 599
Score = 67.4 bits (163), Expect = 3e-11
Identities = 68/322 (21%), Positives = 137/322 (42%), Gaps = 19/322 (5%)
Query: 65 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 124
+N++ +EE K Q ++ E + K L+ LER K P + +L
Sbjct: 177 RNTITNEELKKKNAELQ----EKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTL 232
Query: 125 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEK 184
R + + E E ++++ + ++ + E E + ++ R + ++++KE
Sbjct: 233 QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKEL 292
Query: 185 EEEE----EEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH 240
E+E E+K R + Q ++EK+ + +E E + M R++ + +
Sbjct: 293 REQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 352
Query: 241 KLKHTENTFSRPGGRASVDTK---------EAEGAPQVEAGKRLEELRRRRGETESEEFE 291
K++ E R + E E Q E R E + R E E E
Sbjct: 353 KMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQE 412
Query: 292 KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEI--ER 349
+ QKQ+E E EE + +++ + E+ ++ K +E + K+ E+EEK R +EE+ +
Sbjct: 413 EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 472
Query: 350 RRAEAAEKRQKMPEDGLSDDKK 371
++ EK ++ + ++K
Sbjct: 473 KKMWRQEKMREQEDQMWEQEEK 494
Score = 65.1 bits (157), Expect = 2e-10
Identities = 72/312 (23%), Positives = 144/312 (46%), Gaps = 33/312 (10%)
Query: 27 DEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDD 86
D+EE + ++ RQE++R++++ Q+ +Q E + D+E K ++ D
Sbjct: 464 DQEEMWGQEKKMWRQEKMREQED-----QMWEQEE-----KMRDQEQKMWDQEERMWEQD 513
Query: 87 EAAFLERLARREER--RQKRLQEALERQKEFDPTITDASLSLPSR---RMQNDTAENETT 141
E RL +EER QK++ + E+ +E T + R + E E
Sbjct: 514 E-----RLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKK 568
Query: 142 EKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ 201
+EE+ R++ +++E E + ++ W + EE +E +EK E+EEK + E +
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMREQEEKMW-EQEEKMQEQEEKMWEQEEK-----MWEQE 622
Query: 202 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK 261
+D+ ++++ E+ + ++++ E + + E K++ E + +
Sbjct: 623 EEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMRE-QEEKMREQEEKMQGQEEKM----R 677
Query: 262 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ-KQQEAALELEELKKKREERRKVLEE 320
E E Q + K E+ + RG+ E ++ K Q+E EE+++K EER + +E
Sbjct: 678 EQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREK-EERIRDQKE 736
Query: 321 EEQRRKQEEADR 332
+ Q R E +R
Sbjct: 737 KMQERLPEHEER 748
Score = 59.3 bits (142), Expect = 8e-09
Identities = 56/212 (26%), Positives = 106/212 (50%), Gaps = 23/212 (10%)
Query: 177 NKKEDKEKEEEEEEKPKRG-SIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEV----- 230
+KK D+ EE +E+ + N I +E++KK +E + +K ++
Sbjct: 154 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKEL 213
Query: 231 --KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK---RLEELRRRRGET 285
K + +F+ +++ NT R + +E E + + K + E LR + G+
Sbjct: 214 KRKLERAKFLLPQVQ--TNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM 271
Query: 286 ESEEFEKLKQKQQ---EAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRR 342
+E EK++++++ E EL E +K+ E++K+ E+EEQ ++QEE K+ E+EEK R
Sbjct: 272 REQE-EKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEE---KMWEQEEKMR 327
Query: 343 LKEEIERRRAE---AAEKRQKMPEDGLSDDKK 371
+EE R+ E EK+ + E + D ++
Sbjct: 328 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 359
Score = 44.3 bits (103), Expect = 3e-04
Identities = 70/324 (21%), Positives = 135/324 (41%), Gaps = 66/324 (20%)
Query: 127 PSRRMQNDTAENETTEKEEK-SESRQERYE-IEETETVTKSYQKNDWRDAEE------NK 178
P M T +N+ E ++K ++ RQ + T TK + N+ + E +
Sbjct: 9 PHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNGTNPETTTSEGCHS 68
Query: 179 KEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFM----DRKKGFTEVKSQN 234
ED++K + ++ R I + +D I+ K E+++ + D + F +
Sbjct: 69 PEDEKKASHQHQEALRREI---EAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGE 125
Query: 235 GEFMTHKLKHT-------------ENTFSRPGGRASVDTKEAEGAPQVEAGKRL---EEL 278
+ + +L H+ +T+ + R + + A +E + EEL
Sbjct: 126 SKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEEL 185
Query: 279 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVL-------------EEEEQRR 325
+++ E + E+ + ++ E L ++ELK+K E + +L +EE+ R
Sbjct: 186 KKKNAELQ-EKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELR 244
Query: 326 KQEEADRK-----------LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 374
+QE+ RK LRE+E K R +EE RR+ EKR + E L + +K +
Sbjct: 245 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQ----EKRLREQEKELREQEKELR 300
Query: 375 CFTPKGSSLKIEERAEFLNKSVQK 398
K+ E+ E + + +K
Sbjct: 301 ------EQKKLREQEEQMQEQEEK 318
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 90.5 bits (223), Expect = 3e-18
Identities = 81/343 (23%), Positives = 172/343 (50%), Gaps = 27/343 (7%)
Query: 27 DEEEAARERRRRARQERLRQKQEE----ESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQV 82
++E RE+ + R++ + +++E E GQV +Q + V ++E + QV
Sbjct: 91 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ-----EGQVREQEGQVREQEGQV 145
Query: 83 EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 142
+ + RE+ Q R QE R++E + + + + Q E + E
Sbjct: 146 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQ--VREQEGQVREQEGQMGEQEGQMGE 203
Query: 143 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
+EE+ ++E+ + +E + Q+ R EE E +E+ +++EE+ ++ E Q+
Sbjct: 204 QEEQMGEQEEQMQKQEEQM---GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQ---EEQM 257
Query: 203 K--DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 260
+ +E++++ +E E + M ++K TE + Q GE +++ E R +
Sbjct: 258 RKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGE-QEEQMREQEEQM-REQEEQMREQ 315
Query: 261 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 320
+E + + GK+ E++ ++ + ++ + KQ++Q E E+++K+ E+ RK +
Sbjct: 316 EEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQE-EQMQKQEEQVRK---Q 371
Query: 321 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 363
EEQ RKQEE RK +EE+ R+ +E++ ++ + E++++M E
Sbjct: 372 EEQMRKQEEQMRK--QEEQMRKQEEQMGEQKEQMGEQKEQMRE 412
Score = 75.9 bits (185), Expect = 9e-14
Identities = 69/343 (20%), Positives = 164/343 (47%), Gaps = 27/343 (7%)
Query: 27 DEEEAARERRRRARQERLRQKQEE----ESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQV 82
++E RE+ + R++ + +++E E GQV +Q + V ++E + QV
Sbjct: 56 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ-----EGQVREQEGQVREQEGQV 110
Query: 83 EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 142
+ + RE+ Q R QE R++E + + R + E E
Sbjct: 111 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV----REQEGQVREQEGQV 166
Query: 143 KEEKSESRQERYEIEETETVTKSYQ-KNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ 201
+E++ + R++ ++ E E + + + ++ + ++E++ E+EE+ + + +GE
Sbjct: 167 REQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGE-- 224
Query: 202 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK 261
++E+++K +E E + + +++ + + + +++ E + +
Sbjct: 225 -QEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKE 283
Query: 262 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 321
+ E Q G++ E++R + E + E E+ ++Q+E E EE K+EE+ + E++
Sbjct: 284 QTEQEEQT--GEQEEQMREQ--EEQMREQEEQMREQEEQMREQEEQMGKQEEQ--MWEQK 337
Query: 322 EQRRKQEE----ADRKLREEEEKRRLKEEIERRRAEAAEKRQK 360
EQ +Q+E + ++ E+EE+ + +EE R++ E K+++
Sbjct: 338 EQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEE 380
Score = 71.6 bits (174), Expect = 2e-12
Identities = 66/344 (19%), Positives = 158/344 (45%), Gaps = 25/344 (7%)
Query: 57 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 116
TD++ + + V ++E + QV + + RE+ Q R QE R++E
Sbjct: 43 TDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 102
Query: 117 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE 176
+ + R + E E +E++ + R++ ++ E E + ++ +
Sbjct: 103 VREQEGQV----REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE------QEGQV 152
Query: 177 NKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKG-FTEVKSQNG 235
++E + +E+E + + + G + E ++ ++++ + E + M ++G E + Q G
Sbjct: 153 REQEGQVREQEGQVREQEGQVRE---QEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMG 209
Query: 236 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ 295
E K E G + K+ E + G++ E+++++ + + +E + KQ
Sbjct: 210 EQEEQMQKQEEQM----GEQEEQMRKQEE-----QMGEQEEQVQKQEEQVQKQEEQMRKQ 260
Query: 296 KQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRAEA 354
++Q E E+++++ E+ K E+ EQ + E + ++RE+EE+ R +E++ + +
Sbjct: 261 EEQMREQE-EQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQM 319
Query: 355 AEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 398
E+ ++M + ++ + + K K EE+ + +QK
Sbjct: 320 REQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQK 363
Score = 69.3 bits (168), Expect = 8e-12
Identities = 69/326 (21%), Positives = 157/326 (48%), Gaps = 43/326 (13%)
Query: 27 DEEEAARERRRRARQERLRQKQEE----ESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQV 82
++E RE+ + R++ + +++E E GQV +Q + V ++E + Q+
Sbjct: 147 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ-----EGQVREQEGQMGEQEGQM 201
Query: 83 EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 142
G+ E E++ +EE+ QK+ ++ E++++ + + Q E + +
Sbjct: 202 -GEQE----EQMGEQEEQMQKQEEQMGEQEEQ-----------MRKQEEQMGEQEEQVQK 245
Query: 143 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEE--EEEEKPKRGSIGEN 200
+EE+ + ++E+ +E + + Q + + +KE E+EE E+E+ R +
Sbjct: 246 QEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQM 305
Query: 201 QIKDEKIKKDKEPKEEVKSFMDR-KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD 259
+ ++E++++ +E E + M + ++ E K Q E K E +
Sbjct: 306 REQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEE----------QMG 355
Query: 260 TKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLE 319
+E + Q E ++ EE R++ E ++ E++++++++ + E++ +++E+ R E
Sbjct: 356 EQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMR---E 412
Query: 320 EEEQRRKQEEADRKLREEEEKRRLKE 345
+EEQ +Q+E RK +EE KE
Sbjct: 413 QEEQMGEQKEQMRK--QEEHMGEQKE 436
Score = 59.7 bits (143), Expect = 6e-09
Identities = 44/216 (20%), Positives = 102/216 (47%), Gaps = 11/216 (5%)
Query: 26 DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD 85
+ E + + + QE QKQEE+ +G+ +Q+ + + ++E + QV+
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQKQEEQ-MGEQEEQMR-KQEEQMGEQEEQVQKQEEQVQKQ 253
Query: 86 DEAAFLERLARREERRQKRLQE--ALERQKEFDPTITDASLSLPSRRMQNDTAENETTEK 143
+E + RE+ Q R QE L+++++ + R + E E +
Sbjct: 254 EEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMR 313
Query: 144 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIK 203
E++ + R++ ++ + E ++ W E+ K++++ E+EE+ K+ E Q++
Sbjct: 314 EQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQ----EEQVR 369
Query: 204 --DEKIKKDKEP-KEEVKSFMDRKKGFTEVKSQNGE 236
+E+++K +E +++ + +++ E K Q GE
Sbjct: 370 KQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGE 405
Score = 50.4 bits (119), Expect = 4e-06
Identities = 65/286 (22%), Positives = 127/286 (44%), Gaps = 64/286 (22%)
Query: 142 EKEEKSESRQERYEIEETE-TVTKSYQKNDWRDAEENK----KEDKEKEEEEEEKPKRGS 196
E +EK+ QE ++ ETE + + + K R E +K +E + +E+E + + + G
Sbjct: 8 ELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQ 67
Query: 197 I--GENQIKDE--KIKKDKEPKEEVKSFMDRKKGFT-----EVKSQNGEFMTH--KLKHT 245
+ E Q++++ ++++ + E + + ++G +V+ Q G+ +++
Sbjct: 68 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 127
Query: 246 ENTFSRPGGRA---SVDTKEAEGAPQVEAGK---------------------------RL 275
E G+ +E EG + + G+ ++
Sbjct: 128 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 187
Query: 276 EELRRRRGETESE---------EFEKLKQKQQEAALELEELKKKREER-----RKVLEEE 321
E + GE E + E E+ QKQ+E E EE +K+EE+ +V ++E
Sbjct: 188 REQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQE 247
Query: 322 EQRRKQEEADRK----LREEEEKRRLKEEIERRRAEAAEKRQKMPE 363
EQ +KQEE RK +RE+EE+ R +EE ++ E E+ ++ E
Sbjct: 248 EQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGE 293
Score = 46.2 bits (108), Expect = 7e-05
Identities = 35/173 (20%), Positives = 75/173 (43%), Gaps = 20/173 (11%)
Query: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
Q+ Q+ ++EE E+ + R++ + +++EE + + +Q+ + EE
Sbjct: 277 QMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQ 336
Query: 78 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
E ++ E +E + ++ +E + +Q+E +M+ +
Sbjct: 337 KEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE---------------QMRK---Q 378
Query: 138 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEE 190
E K+E+ +QE E+ E + + QK R+ EE E KE+ ++EE
Sbjct: 379 EEQMRKQEEQMRKQEEQMGEQKEQMGE--QKEQMREQEEQMGEQKEQMRKQEE 429
Score = 41.2 bits (95), Expect = 0.002
Identities = 27/93 (29%), Positives = 54/93 (58%), Gaps = 6/93 (6%)
Query: 276 EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE----EAD 331
EEL+ + E + EE + ++ ++ E L ++ELK+K E + L +E Q R+QE E +
Sbjct: 7 EELKEKNAELQ-EELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQE 65
Query: 332 RKLREEEEKRRLKE-EIERRRAEAAEKRQKMPE 363
++RE+E + R +E ++ + + E+ ++ E
Sbjct: 66 GQVREQEGQVREQEGQVREQEGQVREQEGQVRE 98
Score = 40.0 bits (92), Expect = 0.005
Identities = 35/168 (20%), Positives = 70/168 (41%), Gaps = 34/168 (20%)
Query: 22 QRNDDDEEEAARERRRRARQERLRQ------KQEEESLGQVTDQVEVNAQNSVPDEEAKT 75
Q + +E+ +E + R ++E++R+ KQEE+ Q E Q +E+
Sbjct: 297 QMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQ--- 353
Query: 76 TTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDT 135
E +++ E R++E + ++ +E + +Q+E R+ +
Sbjct: 354 -----MGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEE------------QMRKQEEQM 396
Query: 136 AENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKE 183
E + E+K + R++ ++ E QK R EE+ E KE
Sbjct: 397 GEQKEQMGEQKEQMREQEEQMGE--------QKEQMRKQEEHMGEQKE 436
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 89.4 bits (220), Expect = 8e-18
Identities = 90/369 (24%), Positives = 168/369 (45%), Gaps = 71/369 (19%)
Query: 16 LSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKT 75
L + +++ E+E R+ + R++ RQ+QE + Q + + ++E K
Sbjct: 396 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ---------EEKIREQEEKI 446
Query: 76 TTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDT 135
++ +E + R EE+RQ+ QE + RQ+E
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQE--QEEMWRQEE--------------------- 483
Query: 136 AENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG 195
+ E+ E +++ ++ E E + ++ WR EE +E +EK E+EEK R
Sbjct: 484 ------KIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ-EEKIREQEEKIREQEEKMWR- 535
Query: 196 SIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE----FMTHKLKHTENTFSR 251
++EKI++ +E E + +++K + E K Q E K++ E R
Sbjct: 536 -------QEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR 588
Query: 252 PGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR 311
+ +E + Q E + EE R + E E+ EK+++ Q+E E EE+ +++
Sbjct: 589 Q--EEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE-QEEKIREQEEMTQEQ 645
Query: 312 EER-----RKVLEEEEQRRKQEEA-----------DRKLREEEEKRRLKEEIERRRAEAA 355
EE+ K+ E+EE+ ++QEE ++K+RE+EEK R +EE+ + + E
Sbjct: 646 EEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 705
Query: 356 -EKRQKMPE 363
E+ +KM E
Sbjct: 706 WEQEEKMCE 714
Score = 86.7 bits (213), Expect = 5e-17
Identities = 81/339 (23%), Positives = 161/339 (47%), Gaps = 49/339 (14%)
Query: 27 DEEEAARERRRRAR-QERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD 85
++EE RE + QE++R+++E+ ++ ++ Q ++EAK ++
Sbjct: 388 EKEEKIRELEEKMHEQEKIREQEEKRQ-----EEEKIREQEKRQEQEAKMWRQEEKIREQ 442
Query: 86 DEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE 145
+E R +E++ R +E + Q++ + +R + + + + E
Sbjct: 443 EEKI------REQEKKMWRQEEKIHEQEK---------IREEEKRQEQEEMWRQEEKIHE 487
Query: 146 KSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDE 205
+ E +++ ++ E E + ++ WR EE +E +EK E+EEK R ++E
Sbjct: 488 QEEIWRQKEKMHEQEEKIRKQEEKVWRQ-EEKIREQEEKIREQEEKMWR--------QEE 538
Query: 206 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 265
KI++ +E E + +++K + E K Q E K+ E + +E +
Sbjct: 539 KIREQEEMWREEEKMHEQEKIWEEEKRQEQE---DKMWRQEE---------KIREQEEKV 586
Query: 266 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRR 325
Q E + EE R+ + E ++ EK+++ Q+E E EE K RE+ K+ E+EE +
Sbjct: 587 WRQEEKIREQEEKRQEQEEKMWKQEEKIRE-QEEKIQEQEE--KIREQEEKIREQEEMTQ 643
Query: 326 KQE----EADRKLREEEEKRRLKEEIERRRAEAAEKRQK 360
+QE E + K+ E+EEK + +EE R+ E +++K
Sbjct: 644 EQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEK 682
Score = 83.6 bits (205), Expect = 4e-16
Identities = 72/348 (20%), Positives = 159/348 (45%), Gaps = 19/348 (5%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
+EE +E + +++ + +++EE + + +++ + EE E +++
Sbjct: 305 QEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 364
Query: 88 AAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKS 147
E + +E + +R +E + ++E + + R Q + + E +E++
Sbjct: 365 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 424
Query: 148 ESRQE------RYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ 201
QE +I E E + +K WR E+ +++K +EEE+ ++ + E +
Sbjct: 425 RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 484
Query: 202 I-KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 260
I + E+I + KE E + + +++ + + K++ E R +
Sbjct: 485 IHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQ------EE 538
Query: 261 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 320
K E +++ E + E + +E E +Q+E E EE ++EE K+ E+
Sbjct: 539 KIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEE--KIREQ 596
Query: 321 EEQRRKQEE----ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 364
EE+R++QEE + K+RE+EEK + +EE R + E ++++M ++
Sbjct: 597 EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQE 644
Score = 79.7 bits (195), Expect = 6e-15
Identities = 91/373 (24%), Positives = 173/373 (46%), Gaps = 48/373 (12%)
Query: 43 RLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQ 102
RL Q+QEE+ Q ++ + + ++E K ++ +E RR+E
Sbjct: 293 RLNQQQEEKMWRQ--EEKIQEWEEKIQEQEEKIREQEEKIREQEEKM------RRQEEMM 344
Query: 103 KRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQER-YEIEET-- 159
+E + RQ+E + + + E EKEEK ++E +E EE
Sbjct: 345 WEKEEKMRRQEEM----------MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 394
Query: 160 ETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIK----DEKIKK-DKEPK 214
E K +++ R+ EE ++E+++ E+E+ + + + + K +EKI++ +K+
Sbjct: 395 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 454
Query: 215 EEVKSFMDRKKGFTEVKSQNGEFM---THKLKHTENTFSRPGGRASVDTKEAEGAPQVEA 271
+ + +++K E K Q E M K+ E + + + + +E + Q E
Sbjct: 455 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQ---KEKMHEQEEKIRKQEEK 511
Query: 272 GKRLEELRRRRGETESEEFEKLKQKQQEAALELEEL---KKKREERRKVLEEEEQRRKQE 328
R EE R + E E+ EK+ +Q+E E EE+ ++K E+ K+ EEE ++QE
Sbjct: 512 VWRQEEKIREQEEKIREQEEKM-WRQEEKIREQEEMWREEEKMHEQEKIWEEE---KRQE 567
Query: 329 EADRKLREEEEKRRLKEEI---ERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKI 385
+ D+ R+EE+ R +E++ E + E EKRQ+ E ++K + KI
Sbjct: 568 QEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEK------IREQEEKI 621
Query: 386 EERAEFLNKSVQK 398
+E+ E + + +K
Sbjct: 622 QEQEEKIREQEEK 634
Score = 79.7 bits (195), Expect = 6e-15
Identities = 74/356 (20%), Positives = 160/356 (44%), Gaps = 38/356 (10%)
Query: 21 YQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNT 80
++ ++EE RE+ + R++ + +++EE + + +++ + EE
Sbjct: 312 WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 371
Query: 81 QVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENET 140
E +++ E + +E + + L+E + Q++ +R + + +
Sbjct: 372 MWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ--------EEKRQEEEKIREQE 423
Query: 141 TEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGEN 200
+E++++ ++ +I E E + +K WR E+ +++K +EEE+ ++ + E
Sbjct: 424 KRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 483
Query: 201 QIKD-EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD 259
+I + E+I + KE E + + +++ + + K++ E R
Sbjct: 484 KIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWR-------- 535
Query: 260 TKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLE 319
Q E + EE+ R + +E ++K+QE +E K R+E K+ E
Sbjct: 536 --------QEEKIREQEEMWREEEKMHEQEKIWEEEKRQE-----QEDKMWRQEE-KIRE 581
Query: 320 EEEQRRKQEEADRKLREEEEKRRLKEE----IERRRAEAAEKRQKMPEDGLSDDKK 371
+EE+ +QEE K+RE+EEKR+ +EE E + E EK Q+ E ++K
Sbjct: 582 QEEKVWRQEE---KIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEK 634
Score = 77.8 bits (190), Expect = 2e-14
Identities = 85/335 (25%), Positives = 154/335 (45%), Gaps = 53/335 (15%)
Query: 65 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 124
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 211 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 256
Query: 125 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WR--------- 172
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR
Sbjct: 257 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE 313
Query: 173 ----DAEENKKEDKEKEEEEEEKPKRGS--IGENQIK-----------DEKIKKDKEPKE 215
+ EE +E +EK E+EEK +R + E + K +EK+++ +E
Sbjct: 314 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 373
Query: 216 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD-TKEAEGAPQVEAGKR 274
E + M R++ K + + K+ E + R + +E E + EA
Sbjct: 374 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 433
Query: 275 LEELRRRRGETESEEFEKLKQKQQEAALELEELK--KKREERRKVLEEEEQRRKQEEADR 332
+E + R E + E EK +Q+E E E+++ +KR+E+ ++ +EE+ +QEE R
Sbjct: 434 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR 493
Query: 333 ---KLREEEEK-RRLKEEIERRRAEAAEKRQKMPE 363
K+ E+EEK R+ +E++ R+ + E+ +K+ E
Sbjct: 494 QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528
Score = 57.4 bits (137), Expect = 3e-08
Identities = 77/324 (23%), Positives = 137/324 (42%), Gaps = 35/324 (10%)
Query: 45 RQKQEEESLGQVTD---QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERR 101
RQ + E+ Q+TD Q + + D + K T E E++
Sbjct: 56 RQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGC--HSPEDEQKA 113
Query: 102 QKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 161
+ QEAL R+ E T L+ +Q ++ K+ + E+R + ++
Sbjct: 114 SHQHQEALRRELEAQ-VHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWK 172
Query: 162 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG-SIGENQIKDEKIKKDKEPKEEVKSF 220
++ A + KK D+ EE +E+ + N I DE++K+ +E
Sbjct: 173 FAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQL 232
Query: 221 MDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEEL-- 278
++ +K ++ N + + KL+ + + +A D GK L+ +
Sbjct: 233 VESEKSEIQL---NVKELKRKLERAKLLLPQQQLQAEAD----------HLGKELQSVSA 279
Query: 279 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 338
+ + E+E + +L Q+Q+E EE K+ E EE+ ++QEE K+RE+E
Sbjct: 280 KLQAQVEENELWNRLNQQQEEKMWRQEE---------KIQEWEEKIQEQEE---KIREQE 327
Query: 339 EKRRLKEEIERRRAEAA-EKRQKM 361
EK R +EE RR+ E EK +KM
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKM 351
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 88.6 bits (218), Expect = 1e-17
Identities = 81/363 (22%), Positives = 166/363 (45%), Gaps = 44/363 (12%)
Query: 21 YQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNT 80
++ ++EE RE+ + R++ + +++EE + + EE
Sbjct: 312 WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWE--------------KEEKMRRQEEM 357
Query: 81 QVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENET 140
E +++ LE + +E + + L+E + Q++ +R + + +
Sbjct: 358 MWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKI--------REQEEKRQEEEKIREQE 409
Query: 141 TEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGEN 200
+E++++ ++ +I E E + +K WR E+ +++K +EEE+ ++ + E
Sbjct: 410 KRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 469
Query: 201 QIKD-EKIKKDKEPKEEVKSF--MDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS 257
+I++ E+I + KE E + + K E K + E K++ E R
Sbjct: 470 KIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQE---EKIREQEEKMWRQ--EEK 524
Query: 258 VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ-----KQQEAALELEELKKKRE 312
+ +E + Q E + EE+ + + E E+ EK+++ +Q+E E EE K RE
Sbjct: 525 IREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEE--KIRE 582
Query: 313 ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE----EIERRRAEAAEKRQKMPEDGLSD 368
++ K+ E+EE+ +QEE K+RE+EE + +E E E + E EK Q+ E
Sbjct: 583 QKEKIREQEEKIWEQEE---KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 639
Query: 369 DKK 371
++K
Sbjct: 640 EEK 642
Score = 87.8 bits (216), Expect = 2e-17
Identities = 74/340 (21%), Positives = 163/340 (47%), Gaps = 24/340 (7%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
+EE +E + +++ + +++EE + + +++ + EE E +++
Sbjct: 305 QEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 364
Query: 88 AAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKS 147
LE + +E + + L+E + Q++ +R + + + +E+++
Sbjct: 365 MRRLEEMMWEKEEKIRELEEKMHEQEKIREQ--------EEKRQEEEKIREQEKRQEQEA 416
Query: 148 ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD-EK 206
+ ++ +I E E + +K WR E+ +++K +EEE+ ++ + E +I++ E+
Sbjct: 417 KMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEE 476
Query: 207 IKKDKEPKEEVKSF--MDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAE 264
I + KE E + + K E K + E K++ E R + +E +
Sbjct: 477 IWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQE---EKIREQEEKMWRQ--EEKIREQEEK 531
Query: 265 GAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQR 324
Q E + EE+ + + E E+ EK++++++ E +K RE+ K+ E++E+
Sbjct: 532 IREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE----EKIREQEEKIREQKEKI 587
Query: 325 RKQEEADRKLREEEEKRRLKEEIERRRAEAA-EKRQKMPE 363
R+QEE K+ E+EEK R +EE+ + + E E+ +KM E
Sbjct: 588 REQEE---KIWEQEEKIREQEEMMQEQEEKMWEQEEKMCE 624
Score = 84.0 bits (206), Expect = 3e-16
Identities = 77/333 (23%), Positives = 159/333 (47%), Gaps = 26/333 (7%)
Query: 43 RLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQ 102
RL Q+QEE+ Q ++ + + ++E K ++ +E RR+E
Sbjct: 293 RLNQQQEEKMWRQ--EEKIQEWEEKIQEQEEKIREQEEKIREQEEKM------RRQEEMM 344
Query: 103 KRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETV 162
+E + RQ+E + L + + E EK + E +E+ E + E
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 404
Query: 163 TKSYQKNDWRDAEENKKEDKEKEEEE---EEKPKRGSIGENQIKDEKIKKDKEPKEEVKS 219
+ +K ++A+ ++E+K +E+EE E++ K E + EKI+++++ +E+ +
Sbjct: 405 IREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEM 464
Query: 220 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 279
+ +K ++ Q + + H + + V +E + Q E + EE
Sbjct: 465 WRQEEK----IREQEEIWRQKEKMHEQEKIRKQ--EEKVWRQEEKMHDQEEKIREQEEKM 518
Query: 280 RRRGETESEEFEKLKQKQQEAALELEELKKKREER-----RKVLEEEEQRRKQE---EAD 331
R+ E E+ EK+++ Q+E E EE+ +++EE+ K+ E+E+ RR++E E +
Sbjct: 519 WRQEEKIREQEEKIRE-QEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQE 577
Query: 332 RKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 364
K+RE++EK R +EE + E ++++M ++
Sbjct: 578 EKIREQKEKIREQEEKIWEQEEKIREQEEMMQE 610
Score = 81.3 bits (199), Expect = 2e-15
Identities = 83/323 (25%), Positives = 152/323 (47%), Gaps = 44/323 (13%)
Query: 65 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 124
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 211 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 256
Query: 125 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WR--------- 172
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR
Sbjct: 257 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE 313
Query: 173 ----DAEENKKEDKEKEEEEEEKPKRGSIGENQI--KDEKIKKDKEPKEEVKSFMDRKKG 226
+ EE +E +EK E+EEK +R E + K+EK+++ +E E + M R +
Sbjct: 314 EKIQEQEEKIREQEEKIREQEEKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEKMRRLEE 370
Query: 227 FTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT-KEAEGAPQVEAGKRLEELRRRRGET 285
K + + K+ E + R + +E E + EA +E + R E
Sbjct: 371 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 430
Query: 286 ESEEFEKLKQKQQEAALELEELKK--KREERRKVLEEEEQRRKQEEADR---KLREEEEK 340
+ E EK +Q+E E E++++ KR+E+ ++ +EE+ R+QEE R K+ E+E+
Sbjct: 431 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKI 490
Query: 341 RRLKEEIERRRAEAAEKRQKMPE 363
R+ +E++ R+ + ++ +K+ E
Sbjct: 491 RKQEEKVWRQEEKMHDQEEKIRE 513
Score = 78.6 bits (192), Expect = 1e-14
Identities = 84/344 (24%), Positives = 165/344 (47%), Gaps = 48/344 (13%)
Query: 42 ERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE-- 99
+ L++K E L Q++ A + + ++ + QVE E RL +++E
Sbjct: 245 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE---ENELWNRLNQQQEEK 301
Query: 100 --RRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 157
R+++++QE E+ +E + I + + + + E EKEEK ++E +
Sbjct: 302 MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM--MW 359
Query: 158 ETETVTKSYQKNDWRDAE-----ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKK-DK 211
E E + ++ W E E K ++EK E+EEK + ++EKI++ +K
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ---------EEEKIREQEK 410
Query: 212 EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK---EAEGAPQ 268
++E K + +K ++ Q K++ E R + K E + Q
Sbjct: 411 RQEQEAKMWRQEEK----IREQE-----EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQ 461
Query: 269 VEAGKRLEELRRR----RGETESEEFEKLKQKQQEAALELEEL----KKKREERRKVLEE 320
E ++ E++R + R + + E EK+++++++ + E++ +K RE+ K+ +
Sbjct: 462 EEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQ 521
Query: 321 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMPE 363
EE+ R+QEE K+RE+EEK R +EE+ + + E E+ +KM E
Sbjct: 522 EEKIREQEE---KIREQEEKIREQEEMMQEQEEKMGEQEEKMQE 562
Score = 78.6 bits (192), Expect = 1e-14
Identities = 84/336 (25%), Positives = 157/336 (46%), Gaps = 50/336 (14%)
Query: 27 DEEEAARERRRRAR-QERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD 85
++EE RE + QE++R+++E+ ++ ++ Q ++EAK ++
Sbjct: 374 EKEEKIRELEEKMHEQEKIREQEEKRQ-----EEEKIREQEKRQEQEAKMWRQEEKIREQ 428
Query: 86 DEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE 145
+E R +E++ R +E + Q++ + +R + + + + E
Sbjct: 429 EEKI------REQEKKMWRQEEKIHEQEK---------IREEEKRQEQEEMWRQEEKIRE 473
Query: 146 KSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD- 204
+ E +++ ++ E E + K +K WR EE + +EK E+EEK R E +I++
Sbjct: 474 QEEIWRQKEKMHEQEKIRKQEEKV-WRQ-EEKMHDQEEKIREQEEKMWRQ---EEKIREQ 528
Query: 205 -EKIKKDKEP---KEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 260
EKI++ +E +EE+ + K G E K Q E K++ E +
Sbjct: 529 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQE----KMRRQEE---------KIRE 575
Query: 261 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 320
+E + Q E + EE + E + E E++ Q+Q+E E EE K E+ K+ E+
Sbjct: 576 QEEKIREQKEKIREQEE-KIWEQEEKIREQEEMMQEQEEKMWEQEE--KMCEQEEKMQEQ 632
Query: 321 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAE 356
EE+ R+QEE K+ E+E + R +EE + E E
Sbjct: 633 EEKMRRQEE---KMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 77.0 bits (188), Expect = 4e-14
Identities = 85/350 (24%), Positives = 152/350 (43%), Gaps = 85/350 (24%)
Query: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
+I Q EEE RE+ +R QE +QEE+ + ++E K
Sbjct: 391 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK----------------IREQEEKIRE 434
Query: 78 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
++ +E + R EE+RQ+ QE + RQ+E
Sbjct: 435 QEKKMWRQEEKIHEQEKIREEEKRQE--QEEMWRQEE----------------------- 469
Query: 138 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 197
+ E+ E +++ ++ E E + K +K WR EE + +EK E+EEK R
Sbjct: 470 ----KIREQEEIWRQKEKMHEQEKIRKQEEK-VWRQ-EEKMHDQEEKIREQEEKMWR--- 520
Query: 198 GENQIKDEKIKKDKEP-KEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA 256
++EKI++ +E +E+ + ++++ E + + GE
Sbjct: 521 -----QEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGE-------------------- 555
Query: 257 SVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRK 316
+ E + E +R EE R + E E+ EK+++ Q+E E EE +++EE +
Sbjct: 556 -----QEEKMQEQEKMRRQEEKIREQEEKIREQKEKIRE-QEEKIWEQEEKIREQEEMMQ 609
Query: 317 VLEEE--EQRRKQEEADRKLREEEEK-RRLKEEIERRRAEAAEKRQKMPE 363
EE+ EQ K E + K++E+EEK RR +E++ + ++ +KM E
Sbjct: 610 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 659
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 88.2 bits (217), Expect = 2e-17
Identities = 66/227 (29%), Positives = 114/227 (50%), Gaps = 44/227 (19%)
Query: 137 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 196
++E E+E + E+R+E + E+E R E ++E +++E E+E K +RG
Sbjct: 35 QSEIREREREIETRKEGKKERESE-----------RKKERREREKRKREREKERKRERG- 82
Query: 197 IGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA 256
+K KK + KEE +RKK E +++ GE + K + + GR
Sbjct: 83 --------KKEKKGERKKEE----RERKKRRREKENKEGEEKEKRKKKEK----KERGRT 126
Query: 257 SVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRK 316
S + KE R R+ E + EE ++ ++K++E E E ++K+ ER++
Sbjct: 127 SKEGKE----------------RERKEERKREERKERERKKEEREKERERKERKKRERKQ 170
Query: 317 VLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 363
V E+EE+R+++E +RK RE K R KE + R E ++R+K E
Sbjct: 171 VGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEE 217
Score = 67.4 bits (163), Expect = 3e-11
Identities = 60/245 (24%), Positives = 113/245 (46%), Gaps = 36/245 (14%)
Query: 107 EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSY 166
E ER++E + T + S R + + E E ++E + E ++ER + E+ K
Sbjct: 37 EIREREREIE-TRKEGKKERESER-KKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 167 QKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKG 226
++ R E+ KE +EKE+ +K ++ G + ++ ++ +E K E + +RKK
Sbjct: 95 RERKKRRREKENKEGEEKEKR--KKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152
Query: 227 FTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETE 286
E K E + R V KE E R E+ R+ R + E
Sbjct: 153 ERE-------------KERERKERKKRERKQVGEKEEE---------RKEKERKERKKRE 190
Query: 287 SEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEE 346
E+ K+++ +K+R ER+K +++E+R+K+ + DR+ E++R +E
Sbjct: 191 RNRKERKKERE----------RKERRERKKERKKKEERKKERQKDRQTNWREKERGKRER 240
Query: 347 IERRR 351
ER++
Sbjct: 241 KERKK 245
Score = 63.9 bits (154), Expect = 3e-10
Identities = 62/229 (27%), Positives = 100/229 (43%), Gaps = 52/229 (22%)
Query: 92 ERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQ 151
ER R+ ER ++R +E +++K+ + + RR + + E E EK +K E ++
Sbjct: 65 EREKRKREREKERKRERGKKEKKGERKKEERERK--KRRREKENKEGEEKEKRKKKEKKE 122
Query: 152 E-RYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPK--RGSIGENQIKDEKIK 208
R E E K +K + R E KKE++EKE E +E+ K R +GE E+ +
Sbjct: 123 RGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEK----EEER 178
Query: 209 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 268
K+KE KE K +RK+ KE E
Sbjct: 179 KEKERKERKKRERNRKE---------------------------------RKKERE---- 201
Query: 269 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAA-LELEELKKKREERRK 316
R E R++ + EE +K +QK ++ E E K++R+ER+K
Sbjct: 202 -----RKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 62.4 bits (150), Expect = 1e-09
Identities = 48/175 (27%), Positives = 77/175 (44%), Gaps = 10/175 (5%)
Query: 234 NGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE----------ELRRRRG 283
N E H ++PG ++ + +E E + E K E E R+R
Sbjct: 14 NTELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKRER 73
Query: 284 ETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRL 343
E E + K+K+ E E E KK+R E+ EE+++RK++E + R +E +
Sbjct: 74 EKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKER 133
Query: 344 KEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 398
+ + ER+R E E+ +K E ++K K K K EER E K +K
Sbjct: 134 ERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKK 188
Score = 62.4 bits (150), Expect = 1e-09
Identities = 51/208 (24%), Positives = 91/208 (43%), Gaps = 31/208 (14%)
Query: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
+I ++ E E+ R++ RR R++R R++++E K
Sbjct: 44 EIETRKEGKKERESERKKERREREKRKREREKER----------------------KRER 81
Query: 78 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
+ +G+ + ER RR E+ K +E +R+K+ S R + +
Sbjct: 82 GKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKR 141
Query: 138 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 197
E E+E K E R E E K +K + + E ++E KEKE +E +K +R
Sbjct: 142 EERKERERKKEER-------EKERERKERKKRERKQVGEKEEERKEKERKERKKRERNR- 193
Query: 198 GENQIKDEKIKKDKEPKEEVKSFMDRKK 225
+ + K+ + K+ +E K+E K +RKK
Sbjct: 194 -KERKKERERKERRERKKERKKKEERKK 220
Score = 57.4 bits (137), Expect = 3e-08
Identities = 39/153 (25%), Positives = 74/153 (48%), Gaps = 9/153 (5%)
Query: 228 TEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETES 287
+E++ + E T K E R R + ++ E + + + +E + R + E
Sbjct: 36 SEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEER 95
Query: 288 EEFEKLKQKQQEAALELEELKKKREERR-------KVLEEEEQRRKQE--EADRKLREEE 338
E ++ ++K+ + E E+ KKK ++ R K E +E+R+++E E +RK E E
Sbjct: 96 ERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEERE 155
Query: 339 EKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 371
++R KE +R R + EK ++ E + KK
Sbjct: 156 KERERKERKKRERKQVGEKEEERKEKERKERKK 188
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/161 (19%), Positives = 80/161 (49%), Gaps = 2/161 (1%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
E++ R++ R R++R R+K+ +E + + + + +E K + + ++
Sbjct: 85 EKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREER 144
Query: 88 AAFLERLARREERRQKRLQEALERQK--EFDPTITDASLSLPSRRMQNDTAENETTEKEE 145
+ RE+ R+++ ++ ER++ E + + +R +N + E++E
Sbjct: 145 KERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKE 204
Query: 146 KSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEE 186
+ E ++ER + EE + + ++ +WR+ E K+E KE+++
Sbjct: 205 RRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 87.8 bits (216), Expect = 2e-17
Identities = 86/308 (27%), Positives = 149/308 (48%), Gaps = 37/308 (12%)
Query: 65 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 124
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 199 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 244
Query: 125 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WRDAEENKKED 181
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR EE +E
Sbjct: 245 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ-EEKIQER 300
Query: 182 KEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHK 241
+EK +E+EEK + ++EK+++ +E E + M R++ K + + K
Sbjct: 301 EEKIQEQEEKIRE--------QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 352
Query: 242 LKHTENTFSRPGGRASVDT-KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA 300
+ E + R + +E E + EA +E + R E + E E++ Q+Q+E
Sbjct: 353 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEK 412
Query: 301 ALELEELKKKREERRKVLEEEEQRRKQEEA----DRKLREEEEKRRLKEEIERRRAE-AA 355
E EE K E+ ++ E+EE+ R+QEE ++K+RE+EEK R +EE+ + + E
Sbjct: 413 MGEQEE--KMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMG 470
Query: 356 EKRQKMPE 363
E+ KM E
Sbjct: 471 EQEGKMCE 478
Score = 85.1 bits (209), Expect = 1e-16
Identities = 91/358 (25%), Positives = 169/358 (47%), Gaps = 48/358 (13%)
Query: 33 RERRRRARQERLRQKQEE-----ESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
+E +R+ + +L Q++ + LG+ V Q V + E N Q E
Sbjct: 233 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENEL-WNRLNQQQE---- 287
Query: 88 AAFLERLARREER---RQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKE 144
E++ R+EE+ R++++QE E+ +E + + + + + E EKE
Sbjct: 288 ----EKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 343
Query: 145 EK-----------------SESRQERYEIEETETVTKSYQKNDWRDAEE-NKKEDKEKEE 186
EK E RQE +I E E + K WR E+ ++E+K +E+
Sbjct: 344 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM-WRQEEKIREQEEKIREQ 402
Query: 187 EEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTE 246
EE + + +GE ++EK+ + +E +E + M R++ +++ Q + + K E
Sbjct: 403 EEMMQEQEEKMGE---QEEKMWEQEEEMQEQEEKMRRQE--EKIREQEKKIREQEEKIRE 457
Query: 247 NTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEE 306
+ +E + Q EA + +E + RR E + E EK ++Q+E E EE
Sbjct: 458 QEEMMQEQEEKMGEQEGKMCEQ-EAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516
Query: 307 LKKKREERRKVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRAEAAEKRQKMPE 363
+ +++EE K+ E+EE+ +QEE K++E+EEK RR +E++ + ++ +KM E
Sbjct: 517 MMQEQEE--KMWEQEEKMCEQEE---KMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 82.4 bits (202), Expect = 9e-16
Identities = 84/340 (24%), Positives = 163/340 (47%), Gaps = 30/340 (8%)
Query: 42 ERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERR 101
+ L++K E L Q++ A + + ++ + QVE E RL +++E +
Sbjct: 233 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE---ENELWNRLNQQQEEK 289
Query: 102 QKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQER-YEIEET- 159
R +E ++ ++E I + + + + E EKEEK ++E +E EE
Sbjct: 290 MWRQEEKIQEREE---KIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI 346
Query: 160 -ETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEP---KE 215
E K +++ R+ EE ++E+++ E+E+ + + + ++EKI++ +E +E
Sbjct: 347 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR---QEEKIREQEEKIREQE 403
Query: 216 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL 275
E+ + K G E K E +++ E R + +E + Q E +
Sbjct: 404 EMMQEQEEKMGEQEEKMWEQE---EEMQEQEEKMRRQ--EEKIREQEKKIREQEEKIREQ 458
Query: 276 EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLR 335
EE+ + + E E+ K+ + QEA ++ +E K +R+E K+ E+E++ R+QEE K+R
Sbjct: 459 EEMMQEQEEKMGEQEGKMCE--QEAKMQEQEEKMRRQE-EKIREQEKKIREQEE---KIR 512
Query: 336 EEEEKRRLKE----EIERRRAEAAEKRQKMPEDGLSDDKK 371
E+EE + +E E E + E EK Q+ E ++K
Sbjct: 513 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 552
Score = 57.4 bits (137), Expect = 3e-08
Identities = 48/203 (23%), Positives = 95/203 (46%), Gaps = 9/203 (4%)
Query: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
+I Q EEE RE+ +R QE +QEE+ + + +++ + EE
Sbjct: 358 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK-IREQEEKIREQEEMMQEQEEKMGEQ 416
Query: 78 TNTQVEGDDEAAFLERLARREERR----QKRLQEALERQKEFDPTITDASLSLPSRRMQN 133
E ++E E RR+E + +K+++E E+ +E + + + + + +
Sbjct: 417 EEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQ--EG 474
Query: 134 DTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPK 193
E E +E++ + R++ +I E E + Q+ R+ EE +E +EK E+EEK
Sbjct: 475 KMCEQEAKMQEQEEKMRRQEEKIREQEKKIRE-QEEKIREQEEMMQEQEEKMWEQEEKMC 533
Query: 194 RGSIGENQIKDEKIKKDKEPKEE 216
+ Q ++EK+++ +E E
Sbjct: 534 EQE-EKMQEQEEKMRRQEEKMRE 555
Score = 53.5 bits (127), Expect = 5e-07
Identities = 36/184 (19%), Positives = 91/184 (49%), Gaps = 15/184 (8%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
+EE RE+ + R++ +++EE +G+ +++ + + ++E K ++ ++
Sbjct: 388 QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMW-EQEEEMQEQEEKMRRQEEKIREQEK 446
Query: 88 AAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE---KE 144
RE+ + R QE + +++E + + +MQ + E +E
Sbjct: 447 KI-------REQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE 499
Query: 145 EKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD 204
++ + R++ +I E E + + ++ W + EE E +EK +E+EEK +R E ++++
Sbjct: 500 QEKKIREQEEKIREQEEMMQEQEEKMW-EQEEKMCEQEEKMQEQEEKMRR---QEEKMRE 555
Query: 205 EKIK 208
++++
Sbjct: 556 QEVR 559
Score = 31.6 bits (70), Expect = 1.9
Identities = 22/133 (16%), Positives = 62/133 (46%), Gaps = 6/133 (4%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
+EE RE+ ++ R++ + +++EE + + +++ + + ++EAK ++ +E
Sbjct: 437 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMG-EQEGKMCEQEAKMQEQEEKMRRQEE 495
Query: 88 AAFLERLARREERRQKR-----LQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 142
+ RE+ + R +QE E+ E + + + + + + E + E
Sbjct: 496 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMRE 555
Query: 143 KEEKSESRQERYE 155
+E + ++E+ +
Sbjct: 556 QEVRLRQQEEKMQ 568
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 87.8 bits (216), Expect = 2e-17
Identities = 85/363 (23%), Positives = 177/363 (48%), Gaps = 40/363 (11%)
Query: 21 YQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNT 80
++ ++EE RE+ + R++ + +++EE + + +++ + EE
Sbjct: 373 WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 432
Query: 81 QVEGDDEAAFLE-------RLARREERRQK--RLQEALERQKEFDPTITDASLSLPSRRM 131
E +++ LE ++ +EE+RQ+ +++E +RQ++ +A + ++
Sbjct: 433 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ------EAKMWRQEEKI 486
Query: 132 QNDTAENETTEKEEKSESRQERYEIEET--ETVTKSYQKNDWRDAEENKKED-----KEK 184
+ E + E+EEK ++E+ +E E + Q+ WR E+ ++++ KEK
Sbjct: 487 REQ--EEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEK 544
Query: 185 EEEEEEKPKRGSIGENQIKDEKIKKDKEPK---EEVKSFMDRKKGFTEVKSQNGEFMTHK 241
E+EEK ++ E + E+ D+E K +E K + +K ++ Q + +
Sbjct: 545 IHEQEEKIRKQE--EKMWRQEEKMHDQEEKIREQEEKVWRQEEK----IREQEEKIREQE 598
Query: 242 LKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAA 301
K E + +E + Q E + EE RR+ E E+ +K+++ Q+E
Sbjct: 599 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE-QEEKI 657
Query: 302 LELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRAEAAEKRQK 360
E EE+ +++EE K+ E+EE+ +QEE K++E+EEK RR +E++ + ++ +K
Sbjct: 658 REQEEMMQEQEE--KMWEQEEKMCEQEE---KMQEQEEKMRRQEEKMWEQEVRLRQQEEK 712
Query: 361 MPE 363
M E
Sbjct: 713 MQE 715
Score = 81.3 bits (199), Expect = 2e-15
Identities = 74/320 (23%), Positives = 147/320 (45%), Gaps = 29/320 (9%)
Query: 33 RERRRRARQERLRQKQEE--ESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF 90
+E + R ++E + +K+E+ E ++ +Q ++ Q EE K + E + +
Sbjct: 422 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 481
Query: 91 LERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESR 150
E R +E + + +E + RQ+E + +R + + + + E+ E
Sbjct: 482 QEEKIREQEEKIREQEEKMWRQEE--KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIW 539
Query: 151 QERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKD 210
+++ +I E E + ++ WR EE + +EK E+EEK R ++EKI++
Sbjct: 540 RQKEKIHEQEEKIRKQEEKMWRQ-EEKMHDQEEKIREQEEKVWR--------QEEKIREQ 590
Query: 211 KEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE 270
+E E + + ++ T+ + + K+ E ++ E + E
Sbjct: 591 EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ----------EQEEKMRRQE 640
Query: 271 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE-- 328
R +E + R E + E E++ Q+Q+E E EE K E+ K+ E+EE+ R+QE
Sbjct: 641 EKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE--KMCEQEEKMQEQEEKMRRQEEK 698
Query: 329 --EADRKLREEEEKRRLKEE 346
E + +LR++EEK + +E
Sbjct: 699 MWEQEVRLRQQEEKMQEHQE 718
Score = 80.1 bits (196), Expect = 5e-15
Identities = 84/324 (25%), Positives = 154/324 (47%), Gaps = 45/324 (13%)
Query: 65 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 124
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 272 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 317
Query: 125 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WR--------- 172
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR
Sbjct: 318 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE 374
Query: 173 ----DAEENKKEDKEKEEEEEEKPKRGSIGENQI--KDEKIKKDKEPKEEVKSFMDRKKG 226
+ EE +E +EK E+EEK +R E + K+EK+++ +E E + M R++
Sbjct: 375 EKIQEQEEKIREQEEKIREQEEKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 431
Query: 227 FTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT-KEAEGAPQVEAGKRLEELRRRRGET 285
K + + K+ E + R + +E E + EA +E + R E
Sbjct: 432 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 491
Query: 286 ESEEFEKLKQKQQEAALELEELKK--KREERRKVLEEEEQRRKQEEADR---KLREEEEK 340
+ E E+ +Q+E E E++++ KR+E+ ++ +EE+ R+QEE R K+ E+EEK
Sbjct: 492 KIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEK 551
Query: 341 -RRLKEEIERRRAEAAEKRQKMPE 363
R+ +E++ R+ + ++ +K+ E
Sbjct: 552 IRKQEEKMWRQEEKMHDQEEKIRE 575
Score = 76.3 bits (186), Expect = 7e-14
Identities = 94/398 (23%), Positives = 181/398 (45%), Gaps = 65/398 (16%)
Query: 33 RERRRRARQERLRQKQEE-----ESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
+E +R+ + +L Q++ + LG+ V Q V + E N Q E
Sbjct: 306 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENEL-WNRLNQQQE---- 360
Query: 88 AAFLERLARREERRQK---RLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETT--- 141
E++ R+EE+ Q+ ++QE E+ +E + I + + RR + E E
Sbjct: 361 ----EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM--RRQEEMMWEKEEKMRR 414
Query: 142 ------EKEEKSESRQER-YEIEET--ETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKP 192
EKEEK ++E +E EE E K +++ R+ EE ++E+++ E+E+ +
Sbjct: 415 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 474
Query: 193 KRGSIGENQIK----DEKIKKDKEPK-EEVKSFMDRKKGFTEVKSQNGEFM---THKLKH 244
+ + + K +EKI++ +E + + +++K E K Q E M K++
Sbjct: 475 QEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE 534
Query: 245 TENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALEL 304
E + ++ E + E R +E + R E + + E+ ++Q+E
Sbjct: 535 QEEIW-----------RQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQ 583
Query: 305 EELKKKREERRKVLEEEEQRRKQE----EADRKLREEEEKRRLKEEIERRRAEAAEKRQK 360
EE K RE+ K+ E+EE+ R+QE E + K+ E+EEK +EE + + E++ +
Sbjct: 584 EE--KIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE----KMQEQEEKMR 637
Query: 361 MPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 398
E+ + + +K + KI E+ E + + +K
Sbjct: 638 RQEEKIREQEKKI-----REQEEKIREQEEMMQEQEEK 670
Score = 36.2 bits (82), Expect = 0.077
Identities = 26/155 (16%), Positives = 62/155 (40%), Gaps = 7/155 (4%)
Query: 27 DEEEAARERRRRA--RQERLRQKQE-----EESLGQVTDQVEVNAQNSVPDEEAKTTTTN 79
D+EE RE+ + ++E++R+++E EE + + + + + EE
Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 627
Query: 80 TQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENE 139
E +++ E R +E++ + +E + Q+E + + + + E
Sbjct: 628 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 687
Query: 140 TTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 174
EK + E + E+ + K + + +A
Sbjct: 688 QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 29.6 bits (65), Expect = 7.2
Identities = 21/106 (19%), Positives = 49/106 (46%), Gaps = 12/106 (11%)
Query: 11 RSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPD 70
R ++Q ++ + EE+ + + QE ++QEE+ Q + + +
Sbjct: 602 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQ---------EKKIRE 652
Query: 71 EEAKTTTTNTQVEGDDEAAF--LERLARREERRQKRLQEALERQKE 114
+E K ++ +E + E++ +EE+ Q++ +E + RQ+E
Sbjct: 653 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ-EEKMRRQEE 697
>gi|20070205 ladinin 1 [Homo sapiens]
Length = 517
Score = 87.8 bits (216), Expect = 2e-17
Identities = 113/536 (21%), Positives = 219/536 (40%), Gaps = 54/536 (10%)
Query: 10 RRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVP 69
R+ +ALS +A QR +DEEE RERRRR R E L Q D+ + +A +P
Sbjct: 5 RKDWSALSSLARQRTLEDEEEQERERRRRHRNLSSTTDDEAPRLSQNGDR-QASASERLP 63
Query: 70 D-EEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPS 128
EEA+ D++ L R+ERRQ+R + +A+ +
Sbjct: 64 SVEEAEVPKPLPPASKDEDEDIQSILRTRQERRQRR-------------QVVEAAQAPIQ 110
Query: 129 RRMQNDTAENETT--EKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEE 186
R++ + N + + +K ++ EI +++ Q+ W EE +E EE
Sbjct: 111 ERLEAEEGRNSLSPVQATQKPLVSKKELEIPPRRRLSRE-QRGPWA-LEEESLVGREPEE 168
Query: 187 EEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTE 246
++ P++ + E +K +K + S ++ V + ++ K+ +E
Sbjct: 169 RKKGVPEKSPVLEKSSMPKKTAPEKSLVSDKTSISEK------VLASEKTSLSEKIAVSE 222
Query: 247 NTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEE 306
S + SV K + + G L RR E ++ FEK ++ + +
Sbjct: 223 KRNS--SEKKSVLEKTSVSEKSLAPGMALGSGRRLVSE-KASIFEKALASEKSPTADAKP 279
Query: 307 LKKKREERRKVLEEE-----------EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 355
K+ + L +E +++R + + L ++ R
Sbjct: 280 APKRATASEQPLAQEPPASGGSPATTKEQRGRALPGKNLPSLAKQGASDPPTVASRLPPV 339
Query: 356 EKRQKMP-EDGLSDDKKP--------FKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTH 406
+ K+P ++ +D P K +P+ S +++ + E ++ +S+ +K
Sbjct: 340 TLQVKIPSKEEEADMSSPTQRTYSSSLKRSSPRTISFRMKPKKENSETTLTRSASMKLPD 399
Query: 407 QAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTA 466
K+ +LE+Y +AI ++S K ++L V GV + + ++EK S
Sbjct: 400 NTV---KLGEKLERYHTAIRRSESVKSRGLPCTELFVAPVGVASKRHLFEKELAGQSRAE 456
Query: 467 AGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQS 522
+ KE L V+SR+N W+++T +S P + + +++R W ++S
Sbjct: 457 PASSRKENLRLSGVVTSRLNLWISRT---QESGDQDPQEAQKASSATERTQWGQKS 509
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 81.3 bits (199), Expect = 2e-15
Identities = 75/323 (23%), Positives = 138/323 (42%), Gaps = 43/323 (13%)
Query: 22 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQ 81
+R + E E RER + +ER R++ + + D+ ++ D E + +
Sbjct: 322 RREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDR 381
Query: 82 VEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETT 141
+++ ER RE R++ + ER++E + R + + +++
Sbjct: 382 SRSREKSRDRERERERERERERERERERERERERE----------REREREREREKDKKR 431
Query: 142 EKEEKSESRQERYEIE----ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 197
++EE E ER ++E E E + KN W E K + EKE E EE+ +R
Sbjct: 432 DREEDEEDAYERRKLERKLREKEAAYQERLKN-WEIRERKKTREYEKEAEREEERRR--- 487
Query: 198 GENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS 257
E K+ K KE ++ + D + + K G + +L+ E
Sbjct: 488 -------EMAKEAKRLKEFLEDYDDDR---DDPKYYRGSALQKRLRDREKEM-------- 529
Query: 258 VDTKEAEGAPQVEAGKRLEELRRR-RGETESEEFEKLKQKQQEAALELEELKKKREERRK 316
EA+ + + LEE+R+R E + +L++ +QEA + K+ E +
Sbjct: 530 ----EADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEE 585
Query: 317 VLEEEEQRRKQEEADRKLREEEE 339
EEEE++ K+E+ + + EEEE
Sbjct: 586 --EEEEKQEKEEKREEPMEEEEE 606
Score = 80.9 bits (198), Expect = 3e-15
Identities = 78/361 (21%), Positives = 159/361 (44%), Gaps = 47/361 (13%)
Query: 23 RNDDDEEEAARERRRRARQ-ERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQ 81
+ + + +E +ERR R R+ ER R+++E E + E K +
Sbjct: 297 KKEKERQEIEKERRERERERERERERRERER------------EREREREREKEKERERE 344
Query: 82 VEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETT 141
E D + +R R+ R + +R++ D D S S R + E E
Sbjct: 345 RERDRDR---DRTKERDRDRDRERDRDRDRERSSDRN-KDRSRSREKSRDRERERERERE 400
Query: 142 EKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ 201
+ E+ R+ E E + +K+ RD EE++++ E+ + E + ++ + + +
Sbjct: 401 REREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQER 460
Query: 202 IKDEKI---KKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 258
+K+ +I KK +E ++E + +R++ + + EF+
Sbjct: 461 LKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLE------------------- 501
Query: 259 DTKEAEGAPQVEAGKRLEE-LRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 317
D + P+ G L++ LR R E E++E ++ ++K+ ELEE++++
Sbjct: 502 DYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKE-----ELEEIRQRLLAEGHP 556
Query: 318 LEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFT 377
+ E +R ++EA+R+ + + ++ EE E + E EKR++ E+ ++KP C
Sbjct: 557 DPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKP--CLK 614
Query: 378 P 378
P
Sbjct: 615 P 615
Score = 69.3 bits (168), Expect = 8e-12
Identities = 63/246 (25%), Positives = 112/246 (45%), Gaps = 22/246 (8%)
Query: 143 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
+EEK + +ER EIE+ E + ++ R+ E ++E + + E E+EK + ++
Sbjct: 292 EEEKGKKEKERQEIEK-ERRERERERERERERREREREREREREREKEKERERERERDRD 350
Query: 203 KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 262
+D ++D++ E DR++ K ++ SR R +E
Sbjct: 351 RDRTKERDRDRDRERDRDRDRERSSDRNKDRSR--------------SREKSRDRERERE 396
Query: 263 AEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE- 321
E + E + E R R E E E E+ K K+++ + E+ ++R+ RK+ E+E
Sbjct: 397 RERERERERERERERERERERERERER-EREKDKKRDREEDEEDAYERRKLERKLREKEA 455
Query: 322 ---EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTP 378
E+ + E +RK E EK +EE RR KR K + DD+ K +
Sbjct: 456 AYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYY-- 513
Query: 379 KGSSLK 384
+GS+L+
Sbjct: 514 RGSALQ 519
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 80.5 bits (197), Expect = 4e-15
Identities = 92/399 (23%), Positives = 189/399 (47%), Gaps = 39/399 (9%)
Query: 19 IAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTT 78
+A + +++EEE + +++ Q+ +Q ++ ++ D+ + + + P E + +
Sbjct: 79 VAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGS- 137
Query: 79 NTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAEN 138
+ DD+ L + A+ + ++ + + E + D S + R N + E+
Sbjct: 138 ----DDDDDFNKLPKKAKGKAQKSNKKWDGSEEDE-------DNSKKIKERSRINSSGES 186
Query: 139 ETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIG 198
E +E +SR+ + + ++ + N+ DA K +K+ E++E+ ++
Sbjct: 187 GD-ESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERK---- 241
Query: 199 ENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFM--THKLKHTENTFSRPGGRA 256
+ + K++K KE KEE+++ KK ++ K +F T K K T +T P
Sbjct: 242 KRDEEKAKLRKLKE-KEELET---GKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEE 297
Query: 257 SVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRK 316
+T A E K+ ++ ++++GE E +E EK K + ++E K
Sbjct: 298 KAETPTA-AEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAK------ 350
Query: 317 VLEEEEQRRKQEEADR--KLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 374
L+EEE+R+K+EE +R +L E E KR+ +E +E+ + E ++++K ++ L KK K
Sbjct: 351 -LKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERL---KKEGK 406
Query: 375 CFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSK 413
T S + RAE K +Q + GV+ + ++ K
Sbjct: 407 LLTK--SQREARARAEATLKLLQ-AQGVEVPSKDSLPKK 442
Score = 69.7 bits (169), Expect = 6e-12
Identities = 75/367 (20%), Positives = 157/367 (42%), Gaps = 34/367 (9%)
Query: 22 QRNDDDEEEAA------RERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKT 75
+R DEE+A +E ++++ +QK+ + + T + +V V +
Sbjct: 239 ERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEK 298
Query: 76 TTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDT 135
T T E D+E +++++++K +E E++K+ P+ + MQ
Sbjct: 299 AETPTAAEDDNEGD----KKKKDKKKKKGEKEEKEKEKKKGPSKATV------KAMQEAL 348
Query: 136 AENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG 195
A+ + E+ +K E + +EE E K ++ + E K+++KE++E +++ K
Sbjct: 349 AKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLL 408
Query: 196 SIGENQIKDE-----KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFS 250
+ + + + K+ + + + K + +K+ E K + + K +
Sbjct: 409 TKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESME 468
Query: 251 RPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKK 310
A+V+ E +G P+ E E E E+ E EA EE +K
Sbjct: 469 LC---AAVEVME-QGVPEKEETPPPVE------PEEEEDTEDAGLDDWEAMASDEETEKV 518
Query: 311 REERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED---GLS 367
+ + +E ++EE + + +EE + +EE E +E E+ +K+ ++ G +
Sbjct: 519 EGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKT 578
Query: 368 DDKKPFK 374
DKKP K
Sbjct: 579 LDKKPSK 585
Score = 50.1 bits (118), Expect = 5e-06
Identities = 53/272 (19%), Positives = 117/272 (43%), Gaps = 23/272 (8%)
Query: 27 DEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDD 86
+EE +E+R R +Q+ +K+ + G++ + + A+ A+ T Q +G
Sbjct: 378 EEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREAR-----ARAEATLKLLQAQGV- 431
Query: 87 EAAFLERLARR----EERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 142
E + L ++ E++++K++ + LE ++ + A++ + + + E
Sbjct: 432 EVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVE 491
Query: 143 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
EE+ ++ + E + +K + KE+ E+EEEEEE+ + E +
Sbjct: 492 PEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEE 551
Query: 203 KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 262
++E + E EE + D K + + + M+ ++ S D +
Sbjct: 552 EEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYD-----------SDDDRT 600
Query: 263 AEGAPQVEAGKRLEELRRRRGETESEEFEKLK 294
E +A +R+E +RR +++ EKL+
Sbjct: 601 KEERAYDKAKRRIE--KRRLEHSKNVNTEKLR 630
Score = 46.6 bits (109), Expect = 6e-05
Identities = 77/316 (24%), Positives = 127/316 (40%), Gaps = 80/316 (25%)
Query: 167 QKNDWRDAEENKKED-------KEKEE-----------------------EEE----EKP 192
QK+ + +E KK+D KE EE EEE +K
Sbjct: 38 QKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKK 97
Query: 193 KRGSIGENQI-----------KDEKIKKDKEPKEEVKSFMDRKKGFTEV------KSQNG 235
K+G G+ Q KD K KK +PK E+ S D F ++ K+Q
Sbjct: 98 KKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKS 157
Query: 236 EFMTHKLKHTENTFSRPGGRASVDTK-----EAEGAPQVEAGKRLEELRR-----RRGET 285
+ E+ + R+ +++ E++ Q G++ + + G
Sbjct: 158 NKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNE 217
Query: 286 ESEEFEKLKQKQQEAALELEELKKKREER----RKVLEEEE------QRRKQEEADRKLR 335
+ + K+K Q+ A + E +KKR+E RK+ E+EE + KQ+E+ RK
Sbjct: 218 DDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKF- 276
Query: 336 EEEEKRRLKEEIERRRAEAAEKRQKMP---EDGLSDDKKPFKCFTPKGSSLKIEERAEFL 392
EEE + K ++ A+E++ + P ED DKK KG EE+ +
Sbjct: 277 -EEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEK---EEKEKEK 332
Query: 393 NKSVQKSSGVKSTHQA 408
K K++ VK+ +A
Sbjct: 333 KKGPSKAT-VKAMQEA 347
Score = 37.0 bits (84), Expect = 0.045
Identities = 63/310 (20%), Positives = 115/310 (37%), Gaps = 51/310 (16%)
Query: 175 EENKKEDKEKEEEE-----EEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTE 229
++NK ED K++ + E G+ E + + K KK KE K++ D K E
Sbjct: 5 QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64
Query: 230 VKSQ----NGEFMTHKLKHTENT-----------FSRPGGRASVDTKEAEGAPQVEAGKR 274
+ + + T +K TEN + G + S D ++E ++ +
Sbjct: 65 LSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSK 124
Query: 275 ---LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEAD 331
++ G + ++F KL +K + A +K ++ E+E+ +K +E
Sbjct: 125 KTAKPKVEMYSGSDDDDDFNKLPKKAKGKA------QKSNKKWDGSEEDEDNSKKIKERS 178
Query: 332 RKLREEEEKRRLKEEIERRRAEAAEKRQKMP---EDGLSDDKKPFKCFT----------- 377
R E E ++ R+ + ++ K E G DD FK T
Sbjct: 179 RINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKER 238
Query: 378 -------PKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKS 430
K K++E+ E L + S K + + + S++ T I ++
Sbjct: 239 ERKKRDEEKAKLRKLKEKEE-LETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEE 297
Query: 431 AKPTKPAASD 440
T AA D
Sbjct: 298 KAETPTAAED 307
>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
Length = 675
Score = 80.1 bits (196), Expect = 5e-15
Identities = 93/401 (23%), Positives = 175/401 (43%), Gaps = 62/401 (15%)
Query: 17 SQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV--NAQNSVPDEEAK 74
+++ QR ++ + ER+RR Q+ L +++ + L + +Q+E N EE
Sbjct: 107 AEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGD 166
Query: 75 TTTTNTQV-------EGDDEAAFLERLARREERRQKRLQEALE-RQKEFDPTITDAS-LS 125
+ T V G + F + REE+ + + +E R +E P++ +A LS
Sbjct: 167 DSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLS 226
Query: 126 LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKE 185
L + +D E+E K+E + + EE E + Q+N + AEE ++ E+E
Sbjct: 227 L----VMDDEIESEA--KKESLSPGKLKLTFEELE---RQRQENRKKQAEEEARKRLEEE 277
Query: 186 EEEEEKPKRGSIGENQI----------------------------KDEKIKKDKEPKEEV 217
+ E+ +R + E++ +DEK K ++E + +
Sbjct: 278 KRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRI 337
Query: 218 KSFMDRKKGFTEVKSQN--GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL 275
+ + KK F E + + K F PG + ++ +E E +R
Sbjct: 338 E---EEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPG-KLEINFEELLKQKMEEEKRRT 393
Query: 276 EELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE-------ERRKVLEEEEQRRKQE 328
EE R+ + E E +EFE+L+Q+ E E E RE +R ++ + + K E
Sbjct: 394 EEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFE 453
Query: 329 EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDD 369
+ +L E+E +++++EE RRRA E +++ E+ +D
Sbjct: 454 KIG-QLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEED 493
Score = 73.9 bits (180), Expect = 3e-13
Identities = 110/458 (24%), Positives = 193/458 (42%), Gaps = 82/458 (17%)
Query: 22 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQ 81
QR DE++ +E+ R R+ R+KQE + + D+ +V+++ E+A
Sbjct: 47 QRRSRDEKQRRKEQYIREREWN-RRKQEIKEMLASDDEEDVSSKV----EKAYVPKLTGT 101
Query: 82 VEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAEN--- 138
V+G F E +R+E ++KR +E +R+ E D L R++Q + A+
Sbjct: 102 VKG----RFAEMEKQRQEEQRKRTEEERKRRIEQD--------MLEKRKIQRELAKRAEQ 149
Query: 139 ----ETTEKEEKSESRQERYEIEETETVTKSYQ-----KNDWRDAEENKKEDKEKEEEEE 189
T E SE + I T KSY+ K ++ D E+ ++E+KE+ + EE
Sbjct: 150 IEDINNTGTESASEEGDDSLLI--TVVPVKSYKTSGKMKKNFEDLEK-EREEKERIKYEE 206
Query: 190 EKPKRGSIGENQIKDEKI-------KKDKEPKEEVKSFMDRKKGFTEV--------KSQN 234
+K R +K+ K + + E K+E S K F E+ K Q
Sbjct: 207 DKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQA 266
Query: 235 GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK 294
E +L+ + F + + +E + ++ G R +L+ E E + E K
Sbjct: 267 EEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEK 326
Query: 295 QK-QQEAALELEELKKKREERRK--VLEE-----------------------EEQRRKQE 328
+K ++EA +EE KK E R+ V+++ EE +++
Sbjct: 327 RKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKM 386
Query: 329 EADRKLREEEEKRRL---KEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS---- 381
E +++ EEE K +L K+E E+ R E E+ ++ GLS + + GS
Sbjct: 387 EEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAK 446
Query: 382 --SLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSR 417
K E+ + K +QK + + AI +I R
Sbjct: 447 NLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKER 484
Score = 70.1 bits (170), Expect = 5e-12
Identities = 88/398 (22%), Positives = 164/398 (41%), Gaps = 60/398 (15%)
Query: 10 RRSLAALSQIAYQRNDDDEEEAARE------------RRRRARQERLRQKQEEESLGQVT 57
R SL ++ +D+ E EA +E R RQE +++ EEE+ ++
Sbjct: 216 RPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLE 275
Query: 58 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE-------RLARREERRQKRLQEALE 110
++ EEA+ N E D A + +L+ E RQ+R E +
Sbjct: 276 EEKRAF-------EEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRK 328
Query: 111 RQKEFDPTITDASLSLPSRR----MQNDTAENETTEKEEKSESRQERYEIEETETVTKSY 166
++E I + + R + +D+ E T +E + EE + K
Sbjct: 329 AEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEE---LLKQK 385
Query: 167 QKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKG 226
+ + R EE +K E E++E E+ R +GE + ++E +E +E +K
Sbjct: 386 MEEEKRRTEEERKHKLEMEKQEFEQ-LRQEMGEEEEENETFGLSREYEELIKL------- 437
Query: 227 FTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE---ELRRRRG 283
++G LK + F + G + KE + + E +R E++ R
Sbjct: 438 -----KRSGSIQAKNLK---SKFEKIG---QLSEKEIQKKIEEERARRRAIDLEIKEREA 486
Query: 284 ETESEEFE---KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEK 340
E EE + + +K + +K + E+ K EEEEQRR +E+ + LR + E+
Sbjct: 487 ENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQ--KLLRMQFEQ 544
Query: 341 RRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTP 378
R + ++++R E E+ + ++D++ + P
Sbjct: 545 REIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAP 582
Score = 68.9 bits (167), Expect = 1e-11
Identities = 77/308 (25%), Positives = 141/308 (45%), Gaps = 22/308 (7%)
Query: 83 EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 142
+GD + F REER Q+R ++ +R+KE I + + RR Q + +
Sbjct: 28 KGDVKDKFEAMQRAREERNQRRSRDEKQRRKE--QYIREREWN---RRKQEIKEMLASDD 82
Query: 143 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
+E+ S ++ Y + T TV K + + E+ ++E++ K EEE K + I ++ +
Sbjct: 83 EEDVSSKVEKAYVPKLTGTV-----KGRFAEMEKQRQEEQRKRTEEERKRR---IEQDML 134
Query: 203 KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 262
+ KI+++ + E D TE S+ G+ ++ + G+ + ++
Sbjct: 135 EKRKIQRELAKRAE--QIEDINNTGTESASEEGDDSLLITVVPVKSY-KTSGKMKKNFED 191
Query: 263 AEGAPQVEAGKRLEELRRRRGETESEEFEKLK--QKQQEAALELEELKKKREERRKVLEE 320
E + + + EE +R R E + ++ K + +E E K+ + L
Sbjct: 192 LEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTF 251
Query: 321 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK-KPFKCFTPK 379
EE R+++E +K EEE ++RL+EE +RA +RQ + ED + D K FK + P
Sbjct: 252 EELERQRQENRKKQAEEEARKRLEEE---KRAFEEARRQMVNEDEENQDTAKIFKGYRPG 308
Query: 380 GSSLKIEE 387
L EE
Sbjct: 309 KLKLSFEE 316
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/202 (22%), Positives = 83/202 (41%), Gaps = 33/202 (16%)
Query: 232 SQNGEFMTHKLKHTENTFSRPGGRASVDTK-EAEGAPQVEAGKRL---EELRRRRGETES 287
SQ E + K T+ G+ V K EA + E +R E+ RR+
Sbjct: 5 SQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIRE 64
Query: 288 EEFEKLKQK---------QQEAALELEEL-----------------KKKREERRKVLEEE 321
E+ + KQ+ +++ + ++E+ K+++EE+RK EEE
Sbjct: 65 REWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE 124
Query: 322 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS 381
+RR +++ K + + E + E+IE E + +D L P K + G
Sbjct: 125 RKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSG- 183
Query: 382 SLKIEERAEFLNKSVQKSSGVK 403
K+++ E L K ++ +K
Sbjct: 184 --KMKKNFEDLEKEREEKERIK 203
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 79.3 bits (194), Expect = 8e-15
Identities = 81/321 (25%), Positives = 148/321 (46%), Gaps = 32/321 (9%)
Query: 66 NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE----RRQKRLQEALERQKEFDPTITD 121
NS P+ + ++ T G EA + RE RR++ ++A+ E + + D
Sbjct: 410 NSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDE-EQHLED 468
Query: 122 ASLSLP-SRRMQNDTAENETTEKEEKSESRQERYEIEETET-----VTKSYQKN------ 169
L P S+ + ++ +R ++ T T V KS+ K
Sbjct: 469 EELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRM 528
Query: 170 DWRDAEENKKEDKEKEEEEE-------EKPKRGSIGENQIK-DEKIKKDKEPKEEVKSFM 221
D ++ E + E+ ++EE E E+ KR + E ++K +E+++K + +E V+
Sbjct: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
Query: 222 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR 281
+ KK E K + T K K E + + K+ E +VEA ++ EE RR
Sbjct: 589 EEKKKQIEQKFAQIDEKTEKAK--EERLAEEKAKKKAAAKKME---EVEARRKQEEEARR 643
Query: 282 RGETESEEFEKLKQK--QQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 339
+ EE E+ Q+ Q++ E E L+K E +R + E++RR+QE +++ RE+E
Sbjct: 644 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQER 703
Query: 340 KRRLKEEIERRRAEAAEKRQK 360
+ + + E ER+ AE +R++
Sbjct: 704 REQERREQERQLAEQERRREQ 724
Score = 67.8 bits (164), Expect = 2e-11
Identities = 60/248 (24%), Positives = 114/248 (45%), Gaps = 21/248 (8%)
Query: 126 LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKE 185
L + R + + + + EE R E +++ E + K Q R+ E KE+K+K+
Sbjct: 538 LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQA---RERVEQMKEEKKKQ 594
Query: 186 EEE-----EEKPKRGSIGENQIKDEKIKKDKEPK--EEVKSFMDRKKGFTEVKSQNGEFM 238
E+ +EK ++ E ++ +EK KK K EEV++ R+K E +
Sbjct: 595 IEQKFAQIDEKTEKAK--EERLAEEKAKKKAAAKKMEEVEA---RRKQEEEARRLRWLQQ 649
Query: 239 THKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQ 298
+ + + + ++A A ++ + E + R E E E E+ +Q+++
Sbjct: 650 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERR 709
Query: 299 EAALELEELKKKREERRKVLEEEEQRRKQ------EEADRKLREEEEKRRLKEEIERRRA 352
E +L E +++RE+ R E E Q R++ E+ R+L E+++K + ER+
Sbjct: 710 EQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ 769
Query: 353 EAAEKRQK 360
E EK+ K
Sbjct: 770 EEQEKKAK 777
Score = 59.7 bits (143), Expect = 6e-09
Identities = 76/344 (22%), Positives = 136/344 (39%), Gaps = 47/344 (13%)
Query: 89 AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENET-----TEK 143
++LERL E QK E E +E +P + A +P N N+T T
Sbjct: 357 SYLERLLNVEVP-QKVGSEQKEPPEEAEP-VAAAEPEVPENNGNNSWPHNDTEIANSTPN 414
Query: 144 EEKSESRQERYEIEETETVT-----------KSYQKNDWRDAEENKKEDKEKEEEEEEKP 192
+ + S E + E T + +K ++ A E++ E+EE + P
Sbjct: 415 PKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPP 474
Query: 193 K-----------------RGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 235
+ R + Q + P+ +KSF+ R +
Sbjct: 475 RSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKE 534
Query: 236 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ 295
L+ E + D + +++ +RL ++ + R E + EK KQ
Sbjct: 535 RQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 594
Query: 296 KQQEAALELEELKKKREERRKVLEEEEQRRK-----QEEADRKLREEEEKRRLK----EE 346
+Q+ A E+ +K +EER L EE+ ++K EE + + ++EEE RRL+ EE
Sbjct: 595 IEQKFAQIDEKTEKAKEER---LAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 651
Query: 347 IERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 390
ERR E +K+++ ++ L + + + + +ER E
Sbjct: 652 EERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 695
Score = 53.1 bits (126), Expect = 6e-07
Identities = 47/203 (23%), Positives = 93/203 (45%), Gaps = 40/203 (19%)
Query: 32 ARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFL 91
ARER + ++E+ +KQ E+ Q+ ++ E + + +E+AK ++E +
Sbjct: 580 ARERVEQMKEEK--KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 637
Query: 92 ERLARR-----EERRQKRLQEALERQKEFDPT----ITDASLSLPSR---RMQNDTAENE 139
E ARR +E ++R QE L+++KE + +A R R + + E E
Sbjct: 638 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 697
Query: 140 TTEKEEKSESRQERY-------------------EIEETETVTKSYQKNDWRDAEENKKE 180
E+E + + R+E+ E++E E + ++ R+ EE KK+
Sbjct: 698 RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
Query: 181 DKEK-------EEEEEEKPKRGS 196
++++ +EE+E+K K +
Sbjct: 758 EEQQRLAERQLQEEQEKKAKEAA 780
Score = 45.4 bits (106), Expect = 1e-04
Identities = 72/373 (19%), Positives = 147/373 (39%), Gaps = 48/373 (12%)
Query: 94 LARREERRQKRLQEALERQKEFDPTITDASL--SLPSRRMQNDTAENETTEKEEKSESRQ 151
L ++E +R L ++ +P + + S R + + + +E++E E +
Sbjct: 324 LVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAE 383
Query: 152 ERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDK 211
E V ++ N W + + P+ S G+ + K ++ +
Sbjct: 384 PVAAAEPE--VPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPR 441
Query: 212 EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEA 271
EP + + RK+ + + S+ E +H E+ +P R+ + + V
Sbjct: 442 EPPQSAR----RKRSYKQAVSELDEE-----QHLEDEELQPP-RSKTPSSPCPASKVVRP 491
Query: 272 GKR-LEELRRRR-----GETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRR 325
+ L ++R + + ++ ++ +E +++R E + EE EQ R
Sbjct: 492 LRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLR 551
Query: 326 KQE-EADR-------KLREEEEKRRL--------------KEEIERRRAEAAEKRQKMPE 363
+Q+ E D+ KL+ EE R++ K++IE++ A+ EK +K E
Sbjct: 552 RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 611
Query: 364 DGLSDDKKPFKCFTPKGSSL----KIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLE 419
+ L+++K K K + K EE A L Q+ + HQ + K + E
Sbjct: 612 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE--ERRHQELLQKKKEEEQE 669
Query: 420 QYTSAIEGTKSAK 432
+ A E + A+
Sbjct: 670 RLRKAAEAKRLAE 682
Score = 43.9 bits (102), Expect = 4e-04
Identities = 30/137 (21%), Positives = 62/137 (45%), Gaps = 11/137 (8%)
Query: 22 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQ 81
Q ++ + ++++ QERLR+ E + L + +Q + ++E + Q
Sbjct: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR--EQERREQERREQ 706
Query: 82 VEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETT 141
+ E E+ RRE+ R + +E ER+K +L L ++Q + E +
Sbjct: 707 ERREQERQLAEQERRREQERLQAERELQEREK---------ALRLQKEQLQRELEEKKKK 757
Query: 142 EKEEKSESRQERYEIEE 158
E++++ RQ + E E+
Sbjct: 758 EEQQRLAERQLQEEQEK 774
Score = 38.9 bits (89), Expect = 0.012
Identities = 31/131 (23%), Positives = 62/131 (47%), Gaps = 10/131 (7%)
Query: 11 RSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEE----SLGQVTDQVEVNAQN 66
R A ++A QR + E+ RE+ RR ++ R ++++E+E + +Q + A+
Sbjct: 672 RKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER 731
Query: 67 SVPDEEAKTTTTNTQVEGDDE----AAFLERLARR--EERRQKRLQEALERQKEFDPTIT 120
+ + E Q++ + E +RLA R +E ++K+ +EA K + T+
Sbjct: 732 ELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVD 791
Query: 121 DASLSLPSRRM 131
S + S +M
Sbjct: 792 VQSPACTSYQM 802
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 78.6 bits (192), Expect = 1e-14
Identities = 68/283 (24%), Positives = 128/283 (45%), Gaps = 23/283 (8%)
Query: 83 EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 142
EG ++F +R RE+ RQ+ +EA ER+KE + L RR ++ +
Sbjct: 284 EGHGSSSF-DRELEREKERQRLEREAKEREKERRRS-RSIDRGLERRRSRSRERHRSRSR 341
Query: 143 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
++ R++R E E + D+ D E + +KE+E E ++ S GE +
Sbjct: 342 SRDRKGDRRDRDREREKENERGRRRDRDY-DKERGNEREKERERSRERSKEQRSRGE--V 398
Query: 203 KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 262
+++K K+DK+ + D KK +S++ E KH + SR G+ S +
Sbjct: 399 EEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRE-----RKHRSRSRSRNAGKRSRSRSK 453
Query: 263 AEGAPQVEAGKRLEELRRRRG-ETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 321
+ + K R R G + ++ EK K+++ + +E+ RK +
Sbjct: 454 EKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPS---------KEKSRKRSRSK 504
Query: 322 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 364
E+ K++ +D K + ++ RR + IE+ E+ EK+ K ++
Sbjct: 505 ERSHKRDHSDSKDQSDKHDRRRSQSIEQ---ESQEKQHKNKDE 544
Score = 55.5 bits (132), Expect = 1e-07
Identities = 59/283 (20%), Positives = 116/283 (40%), Gaps = 37/283 (13%)
Query: 121 DASLSLPSRRMQNDTAEN--ETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 178
D + R+++ D E E E+ SR R + + +S ++ R+ +
Sbjct: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
Query: 179 KEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFM 238
D+E E E+E + + E+ K++E + +DR G +S++ E
Sbjct: 290 SFDRELEREKERQ-----------RLEREAKEREKERRRSRSIDR--GLERRRSRSRE-- 334
Query: 239 THKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQ 298
+ + + R G R D R E RG +++K + ++
Sbjct: 335 --RHRSRSRSRDRKGDRRDRD--------------REREKENERGRRRDRDYDKERGNER 378
Query: 299 EAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKR 358
E E E +++ +E+R E EE++ K+++ DR R ++KR K+E + R+ + E++
Sbjct: 379 EK--ERERSRERSKEQRSRGEVEEKKHKEDKDDR--RHRDDKRDSKKEKKHSRSRSRERK 434
Query: 359 QKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSG 401
+ + K+ K S K E + + +S S G
Sbjct: 435 HRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQG 477
Score = 50.4 bits (119), Expect = 4e-06
Identities = 55/280 (19%), Positives = 120/280 (42%), Gaps = 34/280 (12%)
Query: 26 DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD 85
D E E +ER+R R+ + R+K+ S + D+ + + S E ++ + + +GD
Sbjct: 292 DRELEREKERQRLEREAKEREKERRRS--RSIDR-GLERRRSRSRERHRSRSRSRDRKGD 348
Query: 86 DEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE 145
R+ R+K + R +++D + + + E E E
Sbjct: 349 RR--------DRDREREKENERGRRRDRDYD-------------KERGNEREKERERSRE 387
Query: 146 KSESRQERYEIEE---TETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS--IGEN 200
+S+ ++ R E+EE E ++D RD+++ KK + + E + + + S G+
Sbjct: 388 RSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKR 447
Query: 201 QIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 260
K K K E + R + ++ ++ + E K K E++ S+ R +
Sbjct: 448 SRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVE----KSKKREHSPSKEKSRKRSRS 503
Query: 261 KE-AEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQE 299
KE + ++ + ++ RRR ++ +E ++ + K ++
Sbjct: 504 KERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
Score = 44.3 bits (103), Expect = 3e-04
Identities = 40/204 (19%), Positives = 80/204 (39%), Gaps = 30/204 (14%)
Query: 22 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQ 81
+R+ D ++E ER + + R R K E+ S G+V EE K
Sbjct: 365 RRDRDYDKERGNEREKERERSRERSK-EQRSRGEV--------------EEKK------- 402
Query: 82 VEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETT 141
+D+ R +R+ +++K+ + R+++ + SR + +
Sbjct: 403 -HKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKN 461
Query: 142 EKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ 201
E +EKS R T++V KS ++ E+++K + KE + +
Sbjct: 462 ESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKR-------DHSD 514
Query: 202 IKDEKIKKDKEPKEEVKSFMDRKK 225
KD+ K D+ + ++ K+
Sbjct: 515 SKDQSDKHDRRRSQSIEQESQEKQ 538
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 78.2 bits (191), Expect = 2e-14
Identities = 80/316 (25%), Positives = 149/316 (47%), Gaps = 37/316 (11%)
Query: 65 QNSVPDEEAKTTTTNTQVE---GDDEAAFLERLARREERRQKRLQEALERQK-EFDPTIT 120
+N++ DEE K Q + + E + ++ + +R+ +R Q L +Q+ + +
Sbjct: 208 RNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRL 267
Query: 121 DASLSLPSRRMQNDTAENE-----TTEKEEKSESRQERYEIEET-----ETVTKSYQKND 170
L S ++Q ENE ++EEK ++E+ + +E E + ++
Sbjct: 268 GKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKM 327
Query: 171 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDR-----KK 225
WR EE E +EK E+E+K R ++EKI++ +E E + M R ++
Sbjct: 328 WRQ-EEKMHEQEEKIREQEDKMWR--------QEEKIREQEEKIREQEEKMWRQEEKIRE 378
Query: 226 GFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGET 285
+++ Q E + K E R + K E ++ R +E R E
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKI----REQEEEMWRQEE 434
Query: 286 ESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE 345
+ E E++ Q Q+E E+EE K +EE K+ E+EE+ ++QEE K++E+EEK +E
Sbjct: 435 KIRELEEMMQDQEEKLREVEE--KMQEEEEKMQEQEEKIQRQEE---KIQEQEEKTWRQE 489
Query: 346 EIERRRAEAAEKRQKM 361
++ ++ + E+ +KM
Sbjct: 490 KLLKQEEKIWEQEEKM 505
Score = 76.3 bits (186), Expect = 7e-14
Identities = 102/440 (23%), Positives = 199/440 (45%), Gaps = 79/440 (17%)
Query: 44 LRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE---R 100
L++K E L Q++V A + ++ + QVE ++ L + ++EE R
Sbjct: 244 LKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQ--QQEEKMWR 301
Query: 101 RQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETE 160
+++++QE E+ E + I + + + + E + E+E+K ++E+ I E E
Sbjct: 302 QEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEK--IREQE 359
Query: 161 TVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSF 220
+ ++ WR E+ +++D++ +E+EEE ++ +EKI++ +E ++E K +
Sbjct: 360 EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQ---------EEKIREQEEKRQE-KMW 409
Query: 221 MDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRR 280
KK ++ Q+ K++ E R Q E + LEE+ +
Sbjct: 410 RQEKK----MREQD-----EKIREQEEEMWR----------------QEEKIRELEEMMQ 444
Query: 281 RRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEA---DRKLREE 337
+ E E EK+ Q+++E E EE +++EE K+ E+EE+ +QE+ + K+ E+
Sbjct: 445 DQEEKLREVEEKM-QEEEEKMQEQEEKIQRQEE--KIQEQEEKTWRQEKLLKQEEKIWEQ 501
Query: 338 EEKRRLKE----EIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTP-KGSSLKIEERAEFL 392
EEK +E E E + E EK Q+ E + + ++ + ++++E E L
Sbjct: 502 EEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561
Query: 393 NKSVQKS---------SG--------------VKSTHQAAIVSKID---SRLEQYTSAIE 426
K QK+ SG +KS ++ + D L+QY +A +
Sbjct: 562 GKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQ 621
Query: 427 GTKSAKPTKPAASDLPVPAE 446
S K P+ S + A+
Sbjct: 622 QLASGKEALPSCSSRKLRAK 641
Score = 58.9 bits (141), Expect = 1e-08
Identities = 60/296 (20%), Positives = 133/296 (44%), Gaps = 27/296 (9%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
+EE E+ + R++ + ++EE + + +++ + EE K + +++ +E
Sbjct: 330 QEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEE-KIREQDEKIQEQEE 388
Query: 88 AAFL--ERLARREERRQKRLQEALERQKEFDPTITDASLSL--------PSRRMQNDT-- 135
+ E++ +EE+RQ+++ ++ +E D I + + M D
Sbjct: 389 EMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEE 448
Query: 136 ----AENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEK 191
E + E+EEK + ++E+ I+ E + ++ WR + K+E+K E+EE+
Sbjct: 449 KLREVEEKMQEEEEKMQEQEEK--IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMW 506
Query: 192 PKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSR 251
+ + E + K ++ ++ + +EE + + E K Q E +L+ E +
Sbjct: 507 RQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEV---RLQELEERLGK 563
Query: 252 PGGRASVDTKEAEGAPQVEAGKRLEELRR-RRGETESEEFEKLKQKQQEAALELEE 306
G +A + GA + +RL L + E +S+E + L+Q+Q L++
Sbjct: 564 LGQKAEL----LGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQ 615
Score = 39.7 bits (91), Expect = 0.007
Identities = 33/174 (18%), Positives = 77/174 (44%), Gaps = 28/174 (16%)
Query: 26 DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD 85
+ EEE R+ + E + Q QEE+ L +V ++++ + + ++E K +++
Sbjct: 424 EQEEEMWRQEEKIRELEEMMQDQEEK-LREVEEKMQ-EEEEKMQEQEEKIQRQEEKIQEQ 481
Query: 86 DEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE 145
+E + + ++E + +E + RQ+E + E+EE
Sbjct: 482 EEKTWRQEKLLKQEEKIWEQEEKMWRQEE------------------------KMWEQEE 517
Query: 146 KSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGE 199
K + ++E+ + +E + + + W+ E+ ++++ +E EE K G E
Sbjct: 518 KMQEQEEKMQRQEEK--MREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAE 569
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 78.2 bits (191), Expect = 2e-14
Identities = 80/316 (25%), Positives = 149/316 (47%), Gaps = 37/316 (11%)
Query: 65 QNSVPDEEAKTTTTNTQVE---GDDEAAFLERLARREERRQKRLQEALERQK-EFDPTIT 120
+N++ DEE K Q + + E + ++ + +R+ +R Q L +Q+ + +
Sbjct: 208 RNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRL 267
Query: 121 DASLSLPSRRMQNDTAENE-----TTEKEEKSESRQERYEIEET-----ETVTKSYQKND 170
L S ++Q ENE ++EEK ++E+ + +E E + ++
Sbjct: 268 GKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKM 327
Query: 171 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDR-----KK 225
WR EE E +EK E+E+K R ++EKI++ +E E + M R ++
Sbjct: 328 WRQ-EEKMHEQEEKIREQEDKMWR--------QEEKIREQEEKIREQEEKMWRQEEKIRE 378
Query: 226 GFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGET 285
+++ Q E + K E R + K E ++ R +E R E
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKI----REQEEEMWRQEE 434
Query: 286 ESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE 345
+ E E++ Q Q+E E+EE K +EE K+ E+EE+ ++QEE K++E+EEK +E
Sbjct: 435 KIRELEEMMQDQEEKLREVEE--KMQEEEEKMQEQEEKIQRQEE---KIQEQEEKTWRQE 489
Query: 346 EIERRRAEAAEKRQKM 361
++ ++ + E+ +KM
Sbjct: 490 KLLKQEEKIWEQEEKM 505
Score = 77.4 bits (189), Expect = 3e-14
Identities = 112/483 (23%), Positives = 213/483 (44%), Gaps = 93/483 (19%)
Query: 15 ALSQIAYQRNDDDEE-----EAARERRRRARQER---------LRQKQEEESLGQVTDQV 60
ALS Y+ DEE +E+ R E+ L++K E L Q+
Sbjct: 201 ALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQL 260
Query: 61 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE---RRQKRLQEALERQKEFDP 117
+V A + ++ + QVE ++ L + ++EE R+++++QE E+ E +
Sbjct: 261 QVEADRLGKELQSVSAKLQAQVEENELWNLLNQ--QQEEKMWRQEEKIQEQEEKMCEQEL 318
Query: 118 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 177
I + + + + E + E+E+K ++E+ I E E + ++ WR E+
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEK--IREQEEKIREQEEKMWRQEEKI 376
Query: 178 KKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEF 237
+++D++ +E+EEE ++ +EKI++ +E ++E K + KK ++ Q+
Sbjct: 377 REQDEKIQEQEEEMWRQ---------EEKIREQEEKRQE-KMWRQEKK----MREQD--- 419
Query: 238 MTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQ 297
K++ E R Q E + LEE+ + + E E EK+ Q++
Sbjct: 420 --EKIREQEEEMWR----------------QEEKIRELEEMMQDQEEKLREVEEKM-QEE 460
Query: 298 QEAALELEELKKKREERRKVLEEEEQRRKQEEA---DRKLREEEEKRRLKE----EIERR 350
+E E EE +++EE K+ E+EE+ +QE+ + K+ E+EEK +E E E +
Sbjct: 461 EEKMQEQEEKIQRQEE--KIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEK 518
Query: 351 RAEAAEKRQKMPEDGLSDDKKPFKCFTP-KGSSLKIEERAEFLNKSVQKS---------S 400
E EK Q+ E + + ++ + ++++E E L K QK+ S
Sbjct: 519 MQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRES 578
Query: 401 G--------------VKSTHQAAIVSKID---SRLEQYTSAIEGTKSAKPTKPAASDLPV 443
G +KS ++ + D L+QY +A + S K P+ S +
Sbjct: 579 GSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQQLASGKEALPSCSSRKL 638
Query: 444 PAE 446
A+
Sbjct: 639 RAK 641
>gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
sapiens]
Length = 551
Score = 77.8 bits (190), Expect = 2e-14
Identities = 92/393 (23%), Positives = 171/393 (43%), Gaps = 52/393 (13%)
Query: 10 RRSLAALSQIAYQRND--DDEEEAARERRRRA--RQERLRQKQEEESLGQVTDQVEVNAQ 65
R+ + ++ + N D EE A+ER + R +LR +QEEE ++ +NA+
Sbjct: 145 RKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDM--SKIILNAK 202
Query: 66 NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLS 125
+ Q E D E L+++ E ++ + QE LER++ +
Sbjct: 203 CHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREE--------R 254
Query: 126 LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKE 185
+ RR + E E+ +E R++ E E+ + Q+ D +D E +++ + +
Sbjct: 255 IRGRRQIVEQMEKNQEERSLLAEQREQ--EKEQMLEYMEQLQEEDLKDMERRQQQKLKMQ 312
Query: 186 EE------EEEKPKRGSIGENQIKDEKI----KKDKEPKEEVKSFMDRKKGFTEVKSQNG 235
E E +K K + + ++ D+ + KK + E ++ +R + E +
Sbjct: 313 AEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARL 372
Query: 236 EFMTHKLK--HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE---ELRRRRGET----- 285
M K + E R V +E + A K++E ELR+ R E
Sbjct: 373 RAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKE 432
Query: 286 ---------ESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRK-----QEEAD 331
+ +EFE++ + Q+E +E E L+++++ ++ E RR+ Q+E
Sbjct: 433 HALAVQVQRDRDEFERILRAQREQ-IEKERLEEEKKATGRLQHANELRRQVRENQQKEVQ 491
Query: 332 RKLREEEEKRRLKEEIERRRAEAAE-KRQKMPE 363
++ EE RRLKEE ++RR E KR+K+ E
Sbjct: 492 NRIATFEEGRRLKEEAQKRRERIDEIKRKKLEE 524
Score = 42.7 bits (99), Expect = 8e-04
Identities = 46/225 (20%), Positives = 106/225 (47%), Gaps = 34/225 (15%)
Query: 145 EKSESRQERYEIEETETVTKSYQKNDWRDAEE----NKKEDKEKEEEEEEKPKRGSIGEN 200
E+ E+R + ++ E+ T+ + +E N K+ + EE +E+ + N
Sbjct: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
Query: 201 QIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 260
+++ E+ ++E K+ K ++ K H ++ + + + +DT
Sbjct: 182 KLRMEQ---EEELKDMSKIILNAK--------------CHAIRDAQ-ILEKQQIQKELDT 223
Query: 261 KEAEGAPQVEAGK-----RLEELRRRRGETE----SEEFEKLKQKQQEAALELEELKKKR 311
+E +E + R EEL R+R E + E++++ Q+E +L E+ ++++
Sbjct: 224 EEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEK 283
Query: 312 E---ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE 353
E E + L+EE+ + + +KL+ + E +R+ +E ++++AE
Sbjct: 284 EQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAE 328
Score = 40.0 bits (92), Expect = 0.005
Identities = 38/209 (18%), Positives = 92/209 (44%), Gaps = 16/209 (7%)
Query: 199 ENQIKDEKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG 254
E + +D+ KK+KE + K M +K+ + + + +N R
Sbjct: 123 ELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANK 182
Query: 255 RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEK---LKQKQQEAALELEELK--K 309
+E + ++ + +R + E ++ +K ++K+ + +E+E K +
Sbjct: 183 LRMEQEEELKDMSKIILNAKCHAIRDAQ-ILEKQQIQKELDTEEKRLDQMMEVERQKSIQ 241
Query: 310 KREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDD 369
++EE + EE R +++ ++ + +EE+ L E+ E+ + + E +++ E+ L D
Sbjct: 242 RQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDM 301
Query: 370 KKPFKCFTPKGSSLKIEERAEFLNKSVQK 398
++ + LK++ + +N QK
Sbjct: 302 ER------RQQQKLKMQAEIKRINDENQK 324
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 77.4 bits (189), Expect = 3e-14
Identities = 100/425 (23%), Positives = 174/425 (40%), Gaps = 77/425 (18%)
Query: 2 LGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQK--QEEESLGQVTDQ 59
LG S+ +L + Q + + A ERRRR +ER+++ EEE+ Q
Sbjct: 1948 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2007
Query: 60 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ--------EALER 111
+E + EEA+ + E +L +E QKRLQ ++
Sbjct: 2008 LEEVERLKAKVEEARRLRERAEQES------ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 112 QKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSY 166
++E T+ L R + + A E EE + E+ Q R ++EE E + +S
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 167 QKNDWRDAEENKKEDKEKEEEEEEKPKR-----GSIGENQIKDEKIKKDKEPKEEVKSFM 221
++ A+ +K ++E E+E +R ++ + Q D +++K K+ E+
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--- 2178
Query: 222 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD-TKEAEGAPQVE-----AGKRL 275
R+K E + + H +N R + T+ A QVE ++
Sbjct: 2179 -RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237
Query: 276 EELRRRRGETES------------------EEFEKLKQKQQEAA--------------LE 303
EEL + + E+ EE EK+KQ +EAA L
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 304 LEELKKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEA 354
E+L ++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ +
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 355 AEKRQ 359
AE+ Q
Sbjct: 2358 AEETQ 2362
Score = 74.3 bits (181), Expect = 3e-13
Identities = 107/454 (23%), Positives = 203/454 (44%), Gaps = 63/454 (13%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV---- 82
EEE AR +R A + RQ+ E E L +V ++EV A + +EE+++T+ ++
Sbjct: 1733 EEELARLQREAAAATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 83 ------EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 136
E +EAA L LA +R+++ +E RQ+ + L+ + T
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT- 1850
Query: 137 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 196
E E KE+++E+ + R E+ +++Q+ R EE + K EE + ++ S
Sbjct: 1851 EAEIALKEKEAENERLRRLAED-----EAFQR---RRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 197 IGENQ----IKDEKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 248
E + + ++ +++ ++ +EE+ SF G E++ + G + + E+T
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS----NAEDT 1958
Query: 249 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGE---TESEEFEKLKQKQQEAAL-EL 304
S + E E A Q + EE RRR E +S E+ +Q++AAL E+
Sbjct: 1959 L------RSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 305 EELKKKREERRKVLEEEEQ------RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKR 358
E LK K EE R++ E EQ + QE A ++L+ EE+ + + + + ++
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 359 QKMPEDGLSDDKKPFKCFTPKGSSLKIE------------ERAEFLNKSVQKSSGVKSTH 406
++ D L + + + + +++ E AE L +S ++ + ++
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2131
Query: 407 QAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 440
QAA K+ EQ + + A + A+D
Sbjct: 2132 QAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Score = 73.2 bits (178), Expect = 6e-13
Identities = 98/397 (24%), Positives = 165/397 (41%), Gaps = 52/397 (13%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
EE A++R+ + ERLR++ ++ES + +VE+ ++ E A+ Q
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA----- 1537
Query: 88 AAFLERLARREERRQKRLQEA-LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEK 146
LE L + E ++RL++A +ER ++ + A S + + E T + E+
Sbjct: 1538 ---LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 147 SESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEK 206
S ++E ++ R A++ + ++ +EE E E + Q+K +
Sbjct: 1595 S--------LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW------QLKANE 1640
Query: 207 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 266
+ + EEV + E + + E + E R A + ++
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Query: 267 PQVEAGKRL---EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKK 310
+ A +RL +EL R R ETE E E+L + Q+EAA ELE EL K
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760
Query: 311 REERR-----KVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKM 361
R E K EEE R E++ ++L E + R L EE R RA EA +RQ
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Query: 362 PEDGLSDDKKPFKCFTPK----GSSLKIEERAEFLNK 394
ED + + K G + +++ AE K
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857
Score = 72.0 bits (175), Expect = 1e-12
Identities = 90/429 (20%), Positives = 174/429 (40%), Gaps = 35/429 (8%)
Query: 13 LAALSQIAYQRNDDDEEEAARERRRR--ARQERLRQKQ-EEESLGQVTDQVEVNAQNSVP 69
+A +A + +EEA RE RRR A ++ +RQ++ E+ L + E AQ +
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 70 DEEAKTTTTNTQVEGDDEAAFL-ERLARREERRQKRLQEALERQKEFDPTITDASLSLPS 128
E+ +G+ + L E LAR + Q+ E + E + + L S
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 129 RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 188
+ + + + + + +++ E+ R+ E + + + +ED ++ E
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 189 EEK---PKRGSIGE-NQIKDEK--IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL 242
E+ K +IGE ++K E K+KE + E + + F + + + HK
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKA 1889
Query: 243 KHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETE-----SEEFEKLKQKQ 297
E R + K ++ + + G + LR+RR E FEK +
Sbjct: 1890 DIEE--------RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 298 QEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 357
E LEL ++ E+ L +EQ + R+L EEE+RR + E +++ AAE+
Sbjct: 1942 AELELELGRIRSNAED---TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998
Query: 358 RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSR 417
++ + K K+EE ++ Q+S+ Q A ++ +
Sbjct: 1999 EAARQRKAALEEVERLKA--------KVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 418 LEQYTSAIE 426
+ + A++
Sbjct: 2051 EKAHAFAVQ 2059
Score = 70.5 bits (171), Expect = 4e-12
Identities = 85/403 (21%), Positives = 171/403 (42%), Gaps = 44/403 (10%)
Query: 6 GSHGR-RSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNA 64
G+ G ++L A ++ A + +EEA R RR+ + + +++ E E +V + E
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 65 QNS----------VPDEEAKTTTTNTQVEGDDEAAFLERLARR--EERRQKRLQEALERQ 112
+ + EEA+ +VE + A+R E Q + E+
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1589
Query: 113 KEFDPTITDASLSLPSRRMQNDTAENETTEKE---EKSESRQERYEIEETETVTKSYQKN 169
+ + ++ + +++ R + + + E E E++E ER++++ E + Q
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 170 DWRDAEE--NKKEDKEKEEEEEEKPKRG-----SIGENQIKDEKIKKDKEPKE------- 215
+ + + +K+KEE E E +RG ++ + ++ +++++K ++ E
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1709
Query: 216 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVDTKEAEGAPQVE 270
+ + R + TE Q + + +L + T R A + AE +
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Query: 271 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE--RRKVLEEEEQRRKQE 328
+ R EE R E + E + +E A E L+ EE R++ L EE+ R++
Sbjct: 1770 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1829
Query: 329 EADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 364
EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Score = 65.5 bits (158), Expect = 1e-10
Identities = 85/391 (21%), Positives = 157/391 (40%), Gaps = 66/391 (16%)
Query: 29 EEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQV---EGD 85
EEAAR R +R RQ EE++ Q + V A+ EA T ++ E +
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860
Query: 86 DEAAFLERLARREERRQKRLQE-ALERQKEFDPTI------TDASLSLPSRRMQNDTAEN 138
E L RLA E +++RL+E A + + + + + +D+ L +++ +
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
Query: 139 ETTEKE--------EKSESRQERYEIE------ETETVTKSYQKNDWRDAEENK---KED 181
E+E EK+ + + E+E E +S ++ + A + + +E+
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 182 KEKEEEEEEKPKRGSIGENQIKD-----EKIKKDKEPKEEVKSFMDR------------- 223
+ + E EE K + E + E++++ K EE + +R
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 224 ----------KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK 273
+K Q + + L+ ++ + G A + AE A +
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Query: 274 RLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRK 333
E + RR + EE E+LKQ +E A + + E+ RK E+E RR Q E
Sbjct: 2101 EREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE-QAA 2156
Query: 334 LR-------EEEEKRRLKEEIERRRAEAAEK 357
LR E E+ ++ E+ R++A+ ++
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Score = 63.9 bits (154), Expect = 3e-10
Identities = 90/420 (21%), Positives = 175/420 (41%), Gaps = 58/420 (13%)
Query: 38 RARQERLRQKQ----EEESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAF 90
+A +E+LRQ+Q E E G+ ++ + A+ N++ D E + T Q+E A
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVAS 1298
Query: 91 LERLARREERRQKRLQEALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEE 145
+ + + + +QE ++ + + T S +S RRM+ E E +++
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQ 1354
Query: 146 KSESRQERYEIE---ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
++E R+ E+E E + AE KE +++ +EE + + ++ Q
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Query: 203 KD------EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA 256
K +++++ E + + K+ + ++ + E +L+ R G
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-EIRVVRLQLEATERQRGGAEG 1473
Query: 257 SVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 314
+ A A + EA KR EE R R + + E K + + + A+ E + RE++
Sbjct: 1474 ELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 315 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 374
R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------- 1579
Query: 375 CFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSAK 432
+RA F K+ Q ++ H A + + + R +Q A + A+
Sbjct: 1580 -----------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628
Score = 63.9 bits (154), Expect = 3e-10
Identities = 82/392 (20%), Positives = 167/392 (42%), Gaps = 26/392 (6%)
Query: 16 LSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQVTDQVEVNAQNSVPDEEAK 74
L+Q A Q+ EE+A ++ QE + Q+E+S L Q+ + E + + EEA+
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 75 TTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALERQKEFDPTITDASLSLPS 128
+ + ERL + EE+ Q R Q E L ++ E + +
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 129 RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 188
R+ Q AE E +K + RQ+ +E T+ ++ D + +++ + K E
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217
Query: 189 EEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 248
E +R + E ++ +++ ++ K + + + + K F+ + + +
Sbjct: 2218 EAARQRSQV-EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 249 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELK 308
+ R SV +EA Q+ E+L ++R EK+ +++ +A E LK
Sbjct: 2277 -AEEAARLSVAAQEAARLRQLAE----EDLAQQRALA-----EKMLKEKMQAVQEATRLK 2326
Query: 309 KKRE--ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGL 366
+ E +++K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E
Sbjct: 2327 AEAELLQQQKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 367 SDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 398
++ + + + EE A+ K ++
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Score = 62.4 bits (150), Expect = 1e-09
Identities = 89/400 (22%), Positives = 166/400 (41%), Gaps = 36/400 (9%)
Query: 36 RRRARQERLRQKQ---EEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE 92
RR +ERL ++Q E E L +V +E Q + +AK E E
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--E 1399
Query: 93 RLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE 152
+ RREE Q+ Q+E + + ++ Q + AE EE E R
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE--EIRVV 1457
Query: 153 RYEIEETETVT--KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDE-KIKK 209
R ++E TE + R E + K + +EE E+ +R E+Q K + +++
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 210 DKEPKEEVKSFMDRKKGFTEVKS--QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAP 267
K E ++ ++++ ++ E +L+ E +R + V + A+ +
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETAQRSA 1574
Query: 268 QVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQ 327
+ E + +R ++ + E+ Q++ A +L E E R+ ++ E R +
Sbjct: 1575 EAEL-----QSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAERAR 1624
Query: 328 EEADRKLR----EEEEKRRLK---EEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 380
EEA+R+L + E RL+ EE+ ++++ A + +K E+ + ++ K +
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA---EE 1681
Query: 381 SSLKIEERAE-FLNKSVQKSSGVKSTHQAAIVSKIDSRLE 419
+++ E AE L K Q + G AA I R E
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1721
Score = 60.1 bits (144), Expect = 5e-09
Identities = 68/343 (19%), Positives = 156/343 (45%), Gaps = 42/343 (12%)
Query: 29 EEAARERRRR----ARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEG 84
+EAAR R+ A+Q L +K +E + V + + A+ + ++ + +
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347
Query: 85 DDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKE 144
+D+ ++LA + Q+ L+ ERQ++ + + L L M A E +
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 145 EKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD 204
+ ++ + ++ TE T+ + E + ++ + + + R +I E + +
Sbjct: 2406 FRKQAEEIGEKLHRTELATQE------KVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 205 EKIKKDK---EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK 261
EK++++ + K E + +++ E ++ F++ K ++ R ++ +
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK----DSLLQR---ERFIEQE 2512
Query: 262 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 321
+A +LE+L + E + ++L+++QQ ++E+ E +R V E
Sbjct: 2513 KA----------KLEQLF----QDEVAKAQQLREEQQRQQQQMEQ-----ERQRLVASME 2553
Query: 322 EQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMPE 363
E RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++ E
Sbjct: 2554 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2596
Score = 31.6 bits (70), Expect = 1.9
Identities = 28/124 (22%), Positives = 50/124 (40%), Gaps = 10/124 (8%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
++E A+ ++ R Q+R +Q+ E+E V E + +E + Q
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580
Query: 88 AAFLERLARREERRQKRLQ-------EALERQKEFDPTITDASLSLPSRRMQNDTAENET 140
E LA +R +++LQ AL +E + A+ +LP+ R D +
Sbjct: 2581 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPA 2637
Query: 141 TEKE 144
E E
Sbjct: 2638 AEAE 2641
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 77.4 bits (189), Expect = 3e-14
Identities = 100/425 (23%), Positives = 174/425 (40%), Gaps = 77/425 (18%)
Query: 2 LGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQK--QEEESLGQVTDQ 59
LG S+ +L + Q + + A ERRRR +ER+++ EEE+ Q
Sbjct: 1952 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2011
Query: 60 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ--------EALER 111
+E + EEA+ + E +L +E QKRLQ ++
Sbjct: 2012 LEEVERLKAKVEEARRLRERAEQES------ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065
Query: 112 QKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSY 166
++E T+ L R + + A E EE + E+ Q R ++EE E + +S
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2125
Query: 167 QKNDWRDAEENKKEDKEKEEEEEEKPKR-----GSIGENQIKDEKIKKDKEPKEEVKSFM 221
++ A+ +K ++E E+E +R ++ + Q D +++K K+ E+
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--- 2182
Query: 222 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD-TKEAEGAPQVE-----AGKRL 275
R+K E + + H +N R + T+ A QVE ++
Sbjct: 2183 -RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2241
Query: 276 EELRRRRGETES------------------EEFEKLKQKQQEAA--------------LE 303
EEL + + E+ EE EK+KQ +EAA L
Sbjct: 2242 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2301
Query: 304 LEELKKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEA 354
E+L ++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ +
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361
Query: 355 AEKRQ 359
AE+ Q
Sbjct: 2362 AEETQ 2366
Score = 74.3 bits (181), Expect = 3e-13
Identities = 107/454 (23%), Positives = 203/454 (44%), Gaps = 63/454 (13%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV---- 82
EEE AR +R A + RQ+ E E L +V ++EV A + +EE+++T+ ++
Sbjct: 1737 EEELARLQREAAAATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795
Query: 83 ------EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 136
E +EAA L LA +R+++ +E RQ+ + L+ + T
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT- 1854
Query: 137 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 196
E E KE+++E+ + R E+ +++Q+ R EE + K EE + ++ S
Sbjct: 1855 EAEIALKEKEAENERLRRLAED-----EAFQR---RRLEEQAAQHKADIEERLAQLRKAS 1906
Query: 197 IGENQ----IKDEKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 248
E + + ++ +++ ++ +EE+ SF G E++ + G + + E+T
Sbjct: 1907 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS----NAEDT 1962
Query: 249 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGE---TESEEFEKLKQKQQEAAL-EL 304
S + E E A Q + EE RRR E +S E+ +Q++AAL E+
Sbjct: 1963 L------RSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015
Query: 305 EELKKKREERRKVLEEEEQ------RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKR 358
E LK K EE R++ E EQ + QE A ++L+ EE+ + + + + ++
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075
Query: 359 QKMPEDGLSDDKKPFKCFTPKGSSLKIE------------ERAEFLNKSVQKSSGVKSTH 406
++ D L + + + + +++ E AE L +S ++ + ++
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2135
Query: 407 QAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 440
QAA K+ EQ + + A + A+D
Sbjct: 2136 QAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2168
Score = 73.2 bits (178), Expect = 6e-13
Identities = 98/397 (24%), Positives = 165/397 (41%), Gaps = 52/397 (13%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
EE A++R+ + ERLR++ ++ES + +VE+ ++ E A+ Q
Sbjct: 1487 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA----- 1541
Query: 88 AAFLERLARREERRQKRLQEA-LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEK 146
LE L + E ++RL++A +ER ++ + A S + + E T + E+
Sbjct: 1542 ---LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1598
Query: 147 SESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEK 206
S ++E ++ R A++ + ++ +EE E E + Q+K +
Sbjct: 1599 S--------LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW------QLKANE 1644
Query: 207 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 266
+ + EEV + E + + E + E R A + ++
Sbjct: 1645 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1704
Query: 267 PQVEAGKRL---EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKK 310
+ A +RL +EL R R ETE E E+L + Q+EAA ELE EL K
Sbjct: 1705 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1764
Query: 311 REERR-----KVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKM 361
R E K EEE R E++ ++L E + R L EE R RA EA +RQ
Sbjct: 1765 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1824
Query: 362 PEDGLSDDKKPFKCFTPK----GSSLKIEERAEFLNK 394
ED + + K G + +++ AE K
Sbjct: 1825 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1861
Score = 72.0 bits (175), Expect = 1e-12
Identities = 90/429 (20%), Positives = 174/429 (40%), Gaps = 35/429 (8%)
Query: 13 LAALSQIAYQRNDDDEEEAARERRRR--ARQERLRQKQ-EEESLGQVTDQVEVNAQNSVP 69
+A +A + +EEA RE RRR A ++ +RQ++ E+ L + E AQ +
Sbjct: 1655 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1714
Query: 70 DEEAKTTTTNTQVEGDDEAAFL-ERLARREERRQKRLQEALERQKEFDPTITDASLSLPS 128
E+ +G+ + L E LAR + Q+ E + E + + L S
Sbjct: 1715 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1774
Query: 129 RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 188
+ + + + + + +++ E+ R+ E + + + +ED ++ E
Sbjct: 1775 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1834
Query: 189 EEK---PKRGSIGE-NQIKDEK--IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL 242
E+ K +IGE ++K E K+KE + E + + F + + + HK
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKA 1893
Query: 243 KHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETE-----SEEFEKLKQKQ 297
E R + K ++ + + G + LR+RR E FEK +
Sbjct: 1894 DIEE--------RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1945
Query: 298 QEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 357
E LEL ++ E+ L +EQ + R+L EEE+RR + E +++ AAE+
Sbjct: 1946 AELELELGRIRSNAED---TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2002
Query: 358 RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSR 417
++ + K K+EE ++ Q+S+ Q A ++ +
Sbjct: 2003 EAARQRKAALEEVERLKA--------KVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054
Query: 418 LEQYTSAIE 426
+ + A++
Sbjct: 2055 EKAHAFAVQ 2063
Score = 70.5 bits (171), Expect = 4e-12
Identities = 85/403 (21%), Positives = 171/403 (42%), Gaps = 44/403 (10%)
Query: 6 GSHGR-RSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNA 64
G+ G ++L A ++ A + +EEA R RR+ + + +++ E E +V + E
Sbjct: 1474 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1533
Query: 65 QNS----------VPDEEAKTTTTNTQVEGDDEAAFLERLARR--EERRQKRLQEALERQ 112
+ + EEA+ +VE + A+R E Q + E+
Sbjct: 1534 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1593
Query: 113 KEFDPTITDASLSLPSRRMQNDTAENETTEKE---EKSESRQERYEIEETETVTKSYQKN 169
+ + ++ + +++ R + + + E E E++E ER++++ E + Q
Sbjct: 1594 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1653
Query: 170 DWRDAEE--NKKEDKEKEEEEEEKPKRG-----SIGENQIKDEKIKKDKEPKE------- 215
+ + + +K+KEE E E +RG ++ + ++ +++++K ++ E
Sbjct: 1654 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1713
Query: 216 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVDTKEAEGAPQVE 270
+ + R + TE Q + + +L + T R A + AE +
Sbjct: 1714 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1773
Query: 271 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE--RRKVLEEEEQRRKQE 328
+ R EE R E + E + +E A E L+ EE R++ L EE+ R++
Sbjct: 1774 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1833
Query: 329 EADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 364
EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1834 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876
Score = 65.5 bits (158), Expect = 1e-10
Identities = 85/391 (21%), Positives = 157/391 (40%), Gaps = 66/391 (16%)
Query: 29 EEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQV---EGD 85
EEAAR R +R RQ EE++ Q + V A+ EA T ++ E +
Sbjct: 1805 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1864
Query: 86 DEAAFLERLARREERRQKRLQE-ALERQKEFDPTI------TDASLSLPSRRMQNDTAEN 138
E L RLA E +++RL+E A + + + + + +D+ L +++ +
Sbjct: 1865 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1924
Query: 139 ETTEKE--------EKSESRQERYEIE------ETETVTKSYQKNDWRDAEENK---KED 181
E+E EK+ + + E+E E +S ++ + A + + +E+
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1984
Query: 182 KEKEEEEEEKPKRGSIGENQIKD-----EKIKKDKEPKEEVKSFMDR------------- 223
+ + E EE K + E + E++++ K EE + +R
Sbjct: 1985 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044
Query: 224 ----------KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK 273
+K Q + + L+ ++ + G A + AE A +
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2104
Query: 274 RLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRK 333
E + RR + EE E+LKQ +E A + + E+ RK E+E RR Q E
Sbjct: 2105 EREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE-QAA 2160
Query: 334 LR-------EEEEKRRLKEEIERRRAEAAEK 357
LR E E+ ++ E+ R++A+ ++
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2191
Score = 63.9 bits (154), Expect = 3e-10
Identities = 90/420 (21%), Positives = 175/420 (41%), Gaps = 58/420 (13%)
Query: 38 RARQERLRQKQ----EEESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAF 90
+A +E+LRQ+Q E E G+ ++ + A+ N++ D E + T Q+E A
Sbjct: 1246 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVAS 1302
Query: 91 LERLARREERRQKRLQEALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEE 145
+ + + + +QE ++ + + T S +S RRM+ E E +++
Sbjct: 1303 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQ 1358
Query: 146 KSESRQERYEIE---ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
++E R+ E+E E + AE KE +++ +EE + + ++ Q
Sbjct: 1359 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1418
Query: 203 KD------EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA 256
K +++++ E + + K+ + ++ + E +L+ R G
Sbjct: 1419 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-EIRVVRLQLEATERQRGGAEG 1477
Query: 257 SVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 314
+ A A + EA KR EE R R + + E K + + + A+ E + RE++
Sbjct: 1478 ELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1536
Query: 315 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 374
R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------- 1583
Query: 375 CFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSAK 432
+RA F K+ Q ++ H A + + + R +Q A + A+
Sbjct: 1584 -----------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1632
Score = 63.9 bits (154), Expect = 3e-10
Identities = 82/392 (20%), Positives = 167/392 (42%), Gaps = 26/392 (6%)
Query: 16 LSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQVTDQVEVNAQNSVPDEEAK 74
L+Q A Q+ EE+A ++ QE + Q+E+S L Q+ + E + + EEA+
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2101
Query: 75 TTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALERQKEFDPTITDASLSLPS 128
+ + ERL + EE+ Q R Q E L ++ E + +
Sbjct: 2102 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161
Query: 129 RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 188
R+ Q AE E +K + RQ+ +E T+ ++ D + +++ + K E
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2221
Query: 189 EEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 248
E +R + E ++ +++ ++ K + + + + K F+ + + +
Sbjct: 2222 EAARQRSQV-EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2280
Query: 249 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELK 308
+ R SV +EA Q+ E+L ++R EK+ +++ +A E LK
Sbjct: 2281 -AEEAARLSVAAQEAARLRQLAE----EDLAQQRALA-----EKMLKEKMQAVQEATRLK 2330
Query: 309 KKRE--ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGL 366
+ E +++K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E
Sbjct: 2331 AEAELLQQQKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384
Query: 367 SDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 398
++ + + + EE A+ K ++
Sbjct: 2385 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2416
Score = 62.4 bits (150), Expect = 1e-09
Identities = 89/400 (22%), Positives = 166/400 (41%), Gaps = 36/400 (9%)
Query: 36 RRRARQERLRQKQ---EEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE 92
RR +ERL ++Q E E L +V +E Q + +AK E E
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--E 1403
Query: 93 RLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE 152
+ RREE Q+ Q+E + + ++ Q + AE EE E R
Sbjct: 1404 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE--EIRVV 1461
Query: 153 RYEIEETETVT--KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDE-KIKK 209
R ++E TE + R E + K + +EE E+ +R E+Q K + +++
Sbjct: 1462 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1521
Query: 210 DKEPKEEVKSFMDRKKGFTEVKS--QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAP 267
K E ++ ++++ ++ E +L+ E +R + V + A+ +
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETAQRSA 1578
Query: 268 QVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQ 327
+ E + +R ++ + E+ Q++ A +L E E R+ ++ E R +
Sbjct: 1579 EAEL-----QSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAERAR 1628
Query: 328 EEADRKLR----EEEEKRRLK---EEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 380
EEA+R+L + E RL+ EE+ ++++ A + +K E+ + ++ K +
Sbjct: 1629 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA---EE 1685
Query: 381 SSLKIEERAE-FLNKSVQKSSGVKSTHQAAIVSKIDSRLE 419
+++ E AE L K Q + G AA I R E
Sbjct: 1686 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1725
Score = 60.1 bits (144), Expect = 5e-09
Identities = 68/343 (19%), Positives = 156/343 (45%), Gaps = 42/343 (12%)
Query: 29 EEAARERRRR----ARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEG 84
+EAAR R+ A+Q L +K +E + V + + A+ + ++ + +
Sbjct: 2292 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2351
Query: 85 DDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKE 144
+D+ ++LA + Q+ L+ ERQ++ + + L L M A E +
Sbjct: 2352 EDKEQMAQQLAEETQGFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2409
Query: 145 EKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD 204
+ ++ + ++ TE T+ + E + ++ + + + R +I E + +
Sbjct: 2410 FRKQAEEIGEKLHRTELATQE------KVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2463
Query: 205 EKIKKDK---EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK 261
EK++++ + K E + +++ E ++ F++ K ++ R ++ +
Sbjct: 2464 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK----DSLLQR---ERFIEQE 2516
Query: 262 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 321
+A +LE+L + E + ++L+++QQ ++E+ E +R V E
Sbjct: 2517 KA----------KLEQLF----QDEVAKAQQLREEQQRQQQQMEQ-----ERQRLVASME 2557
Query: 322 EQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMPE 363
E RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++ E
Sbjct: 2558 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2600
Score = 31.6 bits (70), Expect = 1.9
Identities = 28/124 (22%), Positives = 50/124 (40%), Gaps = 10/124 (8%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
++E A+ ++ R Q+R +Q+ E+E V E + +E + Q
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2584
Query: 88 AAFLERLARREERRQKRLQ-------EALERQKEFDPTITDASLSLPSRRMQNDTAENET 140
E LA +R +++LQ AL +E + A+ +LP+ R D +
Sbjct: 2585 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPA 2641
Query: 141 TEKE 144
E E
Sbjct: 2642 AEAE 2645
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 77.4 bits (189), Expect = 3e-14
Identities = 100/425 (23%), Positives = 174/425 (40%), Gaps = 77/425 (18%)
Query: 2 LGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQK--QEEESLGQVTDQ 59
LG S+ +L + Q + + A ERRRR +ER+++ EEE+ Q
Sbjct: 1948 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2007
Query: 60 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ--------EALER 111
+E + EEA+ + E +L +E QKRLQ ++
Sbjct: 2008 LEEVERLKAKVEEARRLRERAEQES------ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 112 QKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSY 166
++E T+ L R + + A E EE + E+ Q R ++EE E + +S
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 167 QKNDWRDAEENKKEDKEKEEEEEEKPKR-----GSIGENQIKDEKIKKDKEPKEEVKSFM 221
++ A+ +K ++E E+E +R ++ + Q D +++K K+ E+
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--- 2178
Query: 222 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD-TKEAEGAPQVE-----AGKRL 275
R+K E + + H +N R + T+ A QVE ++
Sbjct: 2179 -RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237
Query: 276 EELRRRRGETES------------------EEFEKLKQKQQEAA--------------LE 303
EEL + + E+ EE EK+KQ +EAA L
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 304 LEELKKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEA 354
E+L ++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ +
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 355 AEKRQ 359
AE+ Q
Sbjct: 2358 AEETQ 2362
Score = 74.3 bits (181), Expect = 3e-13
Identities = 107/454 (23%), Positives = 203/454 (44%), Gaps = 63/454 (13%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV---- 82
EEE AR +R A + RQ+ E E L +V ++EV A + +EE+++T+ ++
Sbjct: 1733 EEELARLQREAAAATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 83 ------EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 136
E +EAA L LA +R+++ +E RQ+ + L+ + T
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT- 1850
Query: 137 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 196
E E KE+++E+ + R E+ +++Q+ R EE + K EE + ++ S
Sbjct: 1851 EAEIALKEKEAENERLRRLAED-----EAFQR---RRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 197 IGENQ----IKDEKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 248
E + + ++ +++ ++ +EE+ SF G E++ + G + + E+T
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS----NAEDT 1958
Query: 249 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGE---TESEEFEKLKQKQQEAAL-EL 304
S + E E A Q + EE RRR E +S E+ +Q++AAL E+
Sbjct: 1959 L------RSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 305 EELKKKREERRKVLEEEEQ------RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKR 358
E LK K EE R++ E EQ + QE A ++L+ EE+ + + + + ++
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 359 QKMPEDGLSDDKKPFKCFTPKGSSLKIE------------ERAEFLNKSVQKSSGVKSTH 406
++ D L + + + + +++ E AE L +S ++ + ++
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2131
Query: 407 QAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 440
QAA K+ EQ + + A + A+D
Sbjct: 2132 QAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Score = 73.2 bits (178), Expect = 6e-13
Identities = 98/397 (24%), Positives = 165/397 (41%), Gaps = 52/397 (13%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
EE A++R+ + ERLR++ ++ES + +VE+ ++ E A+ Q
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA----- 1537
Query: 88 AAFLERLARREERRQKRLQEA-LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEK 146
LE L + E ++RL++A +ER ++ + A S + + E T + E+
Sbjct: 1538 ---LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 147 SESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEK 206
S ++E ++ R A++ + ++ +EE E E + Q+K +
Sbjct: 1595 S--------LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW------QLKANE 1640
Query: 207 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 266
+ + EEV + E + + E + E R A + ++
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Query: 267 PQVEAGKRL---EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKK 310
+ A +RL +EL R R ETE E E+L + Q+EAA ELE EL K
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760
Query: 311 REERR-----KVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKM 361
R E K EEE R E++ ++L E + R L EE R RA EA +RQ
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Query: 362 PEDGLSDDKKPFKCFTPK----GSSLKIEERAEFLNK 394
ED + + K G + +++ AE K
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857
Score = 72.0 bits (175), Expect = 1e-12
Identities = 90/429 (20%), Positives = 174/429 (40%), Gaps = 35/429 (8%)
Query: 13 LAALSQIAYQRNDDDEEEAARERRRR--ARQERLRQKQ-EEESLGQVTDQVEVNAQNSVP 69
+A +A + +EEA RE RRR A ++ +RQ++ E+ L + E AQ +
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 70 DEEAKTTTTNTQVEGDDEAAFL-ERLARREERRQKRLQEALERQKEFDPTITDASLSLPS 128
E+ +G+ + L E LAR + Q+ E + E + + L S
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 129 RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 188
+ + + + + + +++ E+ R+ E + + + +ED ++ E
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 189 EEK---PKRGSIGE-NQIKDEK--IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL 242
E+ K +IGE ++K E K+KE + E + + F + + + HK
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKA 1889
Query: 243 KHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETE-----SEEFEKLKQKQ 297
E R + K ++ + + G + LR+RR E FEK +
Sbjct: 1890 DIEE--------RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 298 QEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 357
E LEL ++ E+ L +EQ + R+L EEE+RR + E +++ AAE+
Sbjct: 1942 AELELELGRIRSNAED---TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998
Query: 358 RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSR 417
++ + K K+EE ++ Q+S+ Q A ++ +
Sbjct: 1999 EAARQRKAALEEVERLKA--------KVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 418 LEQYTSAIE 426
+ + A++
Sbjct: 2051 EKAHAFAVQ 2059
Score = 70.5 bits (171), Expect = 4e-12
Identities = 85/403 (21%), Positives = 171/403 (42%), Gaps = 44/403 (10%)
Query: 6 GSHGR-RSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNA 64
G+ G ++L A ++ A + +EEA R RR+ + + +++ E E +V + E
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 65 QNS----------VPDEEAKTTTTNTQVEGDDEAAFLERLARR--EERRQKRLQEALERQ 112
+ + EEA+ +VE + A+R E Q + E+
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1589
Query: 113 KEFDPTITDASLSLPSRRMQNDTAENETTEKE---EKSESRQERYEIEETETVTKSYQKN 169
+ + ++ + +++ R + + + E E E++E ER++++ E + Q
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 170 DWRDAEE--NKKEDKEKEEEEEEKPKRG-----SIGENQIKDEKIKKDKEPKE------- 215
+ + + +K+KEE E E +RG ++ + ++ +++++K ++ E
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1709
Query: 216 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVDTKEAEGAPQVE 270
+ + R + TE Q + + +L + T R A + AE +
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Query: 271 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE--RRKVLEEEEQRRKQE 328
+ R EE R E + E + +E A E L+ EE R++ L EE+ R++
Sbjct: 1770 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1829
Query: 329 EADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 364
EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Score = 65.5 bits (158), Expect = 1e-10
Identities = 85/391 (21%), Positives = 157/391 (40%), Gaps = 66/391 (16%)
Query: 29 EEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQV---EGD 85
EEAAR R +R RQ EE++ Q + V A+ EA T ++ E +
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860
Query: 86 DEAAFLERLARREERRQKRLQE-ALERQKEFDPTI------TDASLSLPSRRMQNDTAEN 138
E L RLA E +++RL+E A + + + + + +D+ L +++ +
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
Query: 139 ETTEKE--------EKSESRQERYEIE------ETETVTKSYQKNDWRDAEENK---KED 181
E+E EK+ + + E+E E +S ++ + A + + +E+
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 182 KEKEEEEEEKPKRGSIGENQIKD-----EKIKKDKEPKEEVKSFMDR------------- 223
+ + E EE K + E + E++++ K EE + +R
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 224 ----------KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK 273
+K Q + + L+ ++ + G A + AE A +
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Query: 274 RLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRK 333
E + RR + EE E+LKQ +E A + + E+ RK E+E RR Q E
Sbjct: 2101 EREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE-QAA 2156
Query: 334 LR-------EEEEKRRLKEEIERRRAEAAEK 357
LR E E+ ++ E+ R++A+ ++
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Score = 63.9 bits (154), Expect = 3e-10
Identities = 90/420 (21%), Positives = 175/420 (41%), Gaps = 58/420 (13%)
Query: 38 RARQERLRQKQ----EEESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAF 90
+A +E+LRQ+Q E E G+ ++ + A+ N++ D E + T Q+E A
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVAS 1298
Query: 91 LERLARREERRQKRLQEALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEE 145
+ + + + +QE ++ + + T S +S RRM+ E E +++
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQ 1354
Query: 146 KSESRQERYEIE---ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
++E R+ E+E E + AE KE +++ +EE + + ++ Q
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Query: 203 KD------EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA 256
K +++++ E + + K+ + ++ + E +L+ R G
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-EIRVVRLQLEATERQRGGAEG 1473
Query: 257 SVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 314
+ A A + EA KR EE R R + + E K + + + A+ E + RE++
Sbjct: 1474 ELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 315 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 374
R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------- 1579
Query: 375 CFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSAK 432
+RA F K+ Q ++ H A + + + R +Q A + A+
Sbjct: 1580 -----------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628
Score = 63.9 bits (154), Expect = 3e-10
Identities = 82/392 (20%), Positives = 167/392 (42%), Gaps = 26/392 (6%)
Query: 16 LSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQVTDQVEVNAQNSVPDEEAK 74
L+Q A Q+ EE+A ++ QE + Q+E+S L Q+ + E + + EEA+
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 75 TTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALERQKEFDPTITDASLSLPS 128
+ + ERL + EE+ Q R Q E L ++ E + +
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 129 RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 188
R+ Q AE E +K + RQ+ +E T+ ++ D + +++ + K E
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217
Query: 189 EEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 248
E +R + E ++ +++ ++ K + + + + K F+ + + +
Sbjct: 2218 EAARQRSQV-EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 249 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELK 308
+ R SV +EA Q+ E+L ++R EK+ +++ +A E LK
Sbjct: 2277 -AEEAARLSVAAQEAARLRQLAE----EDLAQQRALA-----EKMLKEKMQAVQEATRLK 2326
Query: 309 KKRE--ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGL 366
+ E +++K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E
Sbjct: 2327 AEAELLQQQKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 367 SDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 398
++ + + + EE A+ K ++
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Score = 62.4 bits (150), Expect = 1e-09
Identities = 89/400 (22%), Positives = 166/400 (41%), Gaps = 36/400 (9%)
Query: 36 RRRARQERLRQKQ---EEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE 92
RR +ERL ++Q E E L +V +E Q + +AK E E
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--E 1399
Query: 93 RLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE 152
+ RREE Q+ Q+E + + ++ Q + AE EE E R
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE--EIRVV 1457
Query: 153 RYEIEETETVT--KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDE-KIKK 209
R ++E TE + R E + K + +EE E+ +R E+Q K + +++
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 210 DKEPKEEVKSFMDRKKGFTEVKS--QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAP 267
K E ++ ++++ ++ E +L+ E +R + V + A+ +
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETAQRSA 1574
Query: 268 QVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQ 327
+ E + +R ++ + E+ Q++ A +L E E R+ ++ E R +
Sbjct: 1575 EAEL-----QSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAERAR 1624
Query: 328 EEADRKLR----EEEEKRRLK---EEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 380
EEA+R+L + E RL+ EE+ ++++ A + +K E+ + ++ K +
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA---EE 1681
Query: 381 SSLKIEERAE-FLNKSVQKSSGVKSTHQAAIVSKIDSRLE 419
+++ E AE L K Q + G AA I R E
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1721
Score = 60.1 bits (144), Expect = 5e-09
Identities = 68/343 (19%), Positives = 156/343 (45%), Gaps = 42/343 (12%)
Query: 29 EEAARERRRR----ARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEG 84
+EAAR R+ A+Q L +K +E + V + + A+ + ++ + +
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347
Query: 85 DDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKE 144
+D+ ++LA + Q+ L+ ERQ++ + + L L M A E +
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 145 EKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD 204
+ ++ + ++ TE T+ + E + ++ + + + R +I E + +
Sbjct: 2406 FRKQAEEIGEKLHRTELATQE------KVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 205 EKIKKDK---EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK 261
EK++++ + K E + +++ E ++ F++ K ++ R ++ +
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK----DSLLQR---ERFIEQE 2512
Query: 262 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 321
+A +LE+L + E + ++L+++QQ ++E+ E +R V E
Sbjct: 2513 KA----------KLEQLF----QDEVAKAQQLREEQQRQQQQMEQ-----ERQRLVASME 2553
Query: 322 EQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMPE 363
E RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++ E
Sbjct: 2554 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2596
Score = 31.6 bits (70), Expect = 1.9
Identities = 28/124 (22%), Positives = 50/124 (40%), Gaps = 10/124 (8%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
++E A+ ++ R Q+R +Q+ E+E V E + +E + Q
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580
Query: 88 AAFLERLARREERRQKRLQ-------EALERQKEFDPTITDASLSLPSRRMQNDTAENET 140
E LA +R +++LQ AL +E + A+ +LP+ R D +
Sbjct: 2581 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPA 2637
Query: 141 TEKE 144
E E
Sbjct: 2638 AEAE 2641
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 77.4 bits (189), Expect = 3e-14
Identities = 100/425 (23%), Positives = 174/425 (40%), Gaps = 77/425 (18%)
Query: 2 LGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQK--QEEESLGQVTDQ 59
LG S+ +L + Q + + A ERRRR +ER+++ EEE+ Q
Sbjct: 1916 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1975
Query: 60 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ--------EALER 111
+E + EEA+ + E +L +E QKRLQ ++
Sbjct: 1976 LEEVERLKAKVEEARRLRERAEQES------ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029
Query: 112 QKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSY 166
++E T+ L R + + A E EE + E+ Q R ++EE E + +S
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2089
Query: 167 QKNDWRDAEENKKEDKEKEEEEEEKPKR-----GSIGENQIKDEKIKKDKEPKEEVKSFM 221
++ A+ +K ++E E+E +R ++ + Q D +++K K+ E+
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--- 2146
Query: 222 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD-TKEAEGAPQVE-----AGKRL 275
R+K E + + H +N R + T+ A QVE ++
Sbjct: 2147 -RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2205
Query: 276 EELRRRRGETES------------------EEFEKLKQKQQEAA--------------LE 303
EEL + + E+ EE EK+KQ +EAA L
Sbjct: 2206 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2265
Query: 304 LEELKKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEA 354
E+L ++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ +
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325
Query: 355 AEKRQ 359
AE+ Q
Sbjct: 2326 AEETQ 2330
Score = 74.3 bits (181), Expect = 3e-13
Identities = 107/454 (23%), Positives = 203/454 (44%), Gaps = 63/454 (13%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV---- 82
EEE AR +R A + RQ+ E E L +V ++EV A + +EE+++T+ ++
Sbjct: 1701 EEELARLQREAAAATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759
Query: 83 ------EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 136
E +EAA L LA +R+++ +E RQ+ + L+ + T
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT- 1818
Query: 137 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 196
E E KE+++E+ + R E+ +++Q+ R EE + K EE + ++ S
Sbjct: 1819 EAEIALKEKEAENERLRRLAED-----EAFQR---RRLEEQAAQHKADIEERLAQLRKAS 1870
Query: 197 IGENQ----IKDEKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 248
E + + ++ +++ ++ +EE+ SF G E++ + G + + E+T
Sbjct: 1871 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS----NAEDT 1926
Query: 249 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGE---TESEEFEKLKQKQQEAAL-EL 304
S + E E A Q + EE RRR E +S E+ +Q++AAL E+
Sbjct: 1927 L------RSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979
Query: 305 EELKKKREERRKVLEEEEQ------RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKR 358
E LK K EE R++ E EQ + QE A ++L+ EE+ + + + + ++
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2039
Query: 359 QKMPEDGLSDDKKPFKCFTPKGSSLKIE------------ERAEFLNKSVQKSSGVKSTH 406
++ D L + + + + +++ E AE L +S ++ + ++
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2099
Query: 407 QAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 440
QAA K+ EQ + + A + A+D
Sbjct: 2100 QAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2132
Score = 73.2 bits (178), Expect = 6e-13
Identities = 98/397 (24%), Positives = 165/397 (41%), Gaps = 52/397 (13%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
EE A++R+ + ERLR++ ++ES + +VE+ ++ E A+ Q
Sbjct: 1451 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA----- 1505
Query: 88 AAFLERLARREERRQKRLQEA-LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEK 146
LE L + E ++RL++A +ER ++ + A S + + E T + E+
Sbjct: 1506 ---LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1562
Query: 147 SESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEK 206
S ++E ++ R A++ + ++ +EE E E + Q+K +
Sbjct: 1563 S--------LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW------QLKANE 1608
Query: 207 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 266
+ + EEV + E + + E + E R A + ++
Sbjct: 1609 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1668
Query: 267 PQVEAGKRL---EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKK 310
+ A +RL +EL R R ETE E E+L + Q+EAA ELE EL K
Sbjct: 1669 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1728
Query: 311 REERR-----KVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKM 361
R E K EEE R E++ ++L E + R L EE R RA EA +RQ
Sbjct: 1729 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1788
Query: 362 PEDGLSDDKKPFKCFTPK----GSSLKIEERAEFLNK 394
ED + + K G + +++ AE K
Sbjct: 1789 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1825
Score = 72.0 bits (175), Expect = 1e-12
Identities = 90/429 (20%), Positives = 174/429 (40%), Gaps = 35/429 (8%)
Query: 13 LAALSQIAYQRNDDDEEEAARERRRR--ARQERLRQKQ-EEESLGQVTDQVEVNAQNSVP 69
+A +A + +EEA RE RRR A ++ +RQ++ E+ L + E AQ +
Sbjct: 1619 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1678
Query: 70 DEEAKTTTTNTQVEGDDEAAFL-ERLARREERRQKRLQEALERQKEFDPTITDASLSLPS 128
E+ +G+ + L E LAR + Q+ E + E + + L S
Sbjct: 1679 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1738
Query: 129 RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 188
+ + + + + + +++ E+ R+ E + + + +ED ++ E
Sbjct: 1739 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1798
Query: 189 EEK---PKRGSIGE-NQIKDEK--IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL 242
E+ K +IGE ++K E K+KE + E + + F + + + HK
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKA 1857
Query: 243 KHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETE-----SEEFEKLKQKQ 297
E R + K ++ + + G + LR+RR E FEK +
Sbjct: 1858 DIEE--------RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1909
Query: 298 QEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 357
E LEL ++ E+ L +EQ + R+L EEE+RR + E +++ AAE+
Sbjct: 1910 AELELELGRIRSNAED---TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1966
Query: 358 RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSR 417
++ + K K+EE ++ Q+S+ Q A ++ +
Sbjct: 1967 EAARQRKAALEEVERLKA--------KVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018
Query: 418 LEQYTSAIE 426
+ + A++
Sbjct: 2019 EKAHAFAVQ 2027
Score = 70.5 bits (171), Expect = 4e-12
Identities = 85/403 (21%), Positives = 171/403 (42%), Gaps = 44/403 (10%)
Query: 6 GSHGR-RSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNA 64
G+ G ++L A ++ A + +EEA R RR+ + + +++ E E +V + E
Sbjct: 1438 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1497
Query: 65 QNS----------VPDEEAKTTTTNTQVEGDDEAAFLERLARR--EERRQKRLQEALERQ 112
+ + EEA+ +VE + A+R E Q + E+
Sbjct: 1498 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1557
Query: 113 KEFDPTITDASLSLPSRRMQNDTAENETTEKE---EKSESRQERYEIEETETVTKSYQKN 169
+ + ++ + +++ R + + + E E E++E ER++++ E + Q
Sbjct: 1558 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1617
Query: 170 DWRDAEE--NKKEDKEKEEEEEEKPKRG-----SIGENQIKDEKIKKDKEPKE------- 215
+ + + +K+KEE E E +RG ++ + ++ +++++K ++ E
Sbjct: 1618 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1677
Query: 216 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVDTKEAEGAPQVE 270
+ + R + TE Q + + +L + T R A + AE +
Sbjct: 1678 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1737
Query: 271 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE--RRKVLEEEEQRRKQE 328
+ R EE R E + E + +E A E L+ EE R++ L EE+ R++
Sbjct: 1738 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1797
Query: 329 EADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 364
EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1798 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840
Score = 65.5 bits (158), Expect = 1e-10
Identities = 85/391 (21%), Positives = 157/391 (40%), Gaps = 66/391 (16%)
Query: 29 EEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQV---EGD 85
EEAAR R +R RQ EE++ Q + V A+ EA T ++ E +
Sbjct: 1769 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1828
Query: 86 DEAAFLERLARREERRQKRLQE-ALERQKEFDPTI------TDASLSLPSRRMQNDTAEN 138
E L RLA E +++RL+E A + + + + + +D+ L +++ +
Sbjct: 1829 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1888
Query: 139 ETTEKE--------EKSESRQERYEIE------ETETVTKSYQKNDWRDAEENK---KED 181
E+E EK+ + + E+E E +S ++ + A + + +E+
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1948
Query: 182 KEKEEEEEEKPKRGSIGENQIKD-----EKIKKDKEPKEEVKSFMDR------------- 223
+ + E EE K + E + E++++ K EE + +R
Sbjct: 1949 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2008
Query: 224 ----------KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK 273
+K Q + + L+ ++ + G A + AE A +
Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2068
Query: 274 RLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRK 333
E + RR + EE E+LKQ +E A + + E+ RK E+E RR Q E
Sbjct: 2069 EREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE-QAA 2124
Query: 334 LR-------EEEEKRRLKEEIERRRAEAAEK 357
LR E E+ ++ E+ R++A+ ++
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2155
Score = 63.9 bits (154), Expect = 3e-10
Identities = 90/420 (21%), Positives = 175/420 (41%), Gaps = 58/420 (13%)
Query: 38 RARQERLRQKQ----EEESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAF 90
+A +E+LRQ+Q E E G+ ++ + A+ N++ D E + T Q+E A
Sbjct: 1210 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVAS 1266
Query: 91 LERLARREERRQKRLQEALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEE 145
+ + + + +QE ++ + + T S +S RRM+ E E +++
Sbjct: 1267 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQ 1322
Query: 146 KSESRQERYEIE---ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
++E R+ E+E E + AE KE +++ +EE + + ++ Q
Sbjct: 1323 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1382
Query: 203 KD------EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA 256
K +++++ E + + K+ + ++ + E +L+ R G
Sbjct: 1383 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-EIRVVRLQLEATERQRGGAEG 1441
Query: 257 SVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 314
+ A A + EA KR EE R R + + E K + + + A+ E + RE++
Sbjct: 1442 ELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1500
Query: 315 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 374
R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------- 1547
Query: 375 CFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSAK 432
+RA F K+ Q ++ H A + + + R +Q A + A+
Sbjct: 1548 -----------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1596
Score = 63.9 bits (154), Expect = 3e-10
Identities = 82/392 (20%), Positives = 167/392 (42%), Gaps = 26/392 (6%)
Query: 16 LSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQVTDQVEVNAQNSVPDEEAK 74
L+Q A Q+ EE+A ++ QE + Q+E+S L Q+ + E + + EEA+
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2065
Query: 75 TTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALERQKEFDPTITDASLSLPS 128
+ + ERL + EE+ Q R Q E L ++ E + +
Sbjct: 2066 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125
Query: 129 RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 188
R+ Q AE E +K + RQ+ +E T+ ++ D + +++ + K E
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2185
Query: 189 EEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 248
E +R + E ++ +++ ++ K + + + + K F+ + + +
Sbjct: 2186 EAARQRSQV-EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2244
Query: 249 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELK 308
+ R SV +EA Q+ E+L ++R EK+ +++ +A E LK
Sbjct: 2245 -AEEAARLSVAAQEAARLRQLAE----EDLAQQRALA-----EKMLKEKMQAVQEATRLK 2294
Query: 309 KKRE--ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGL 366
+ E +++K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E
Sbjct: 2295 AEAELLQQQKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2348
Query: 367 SDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 398
++ + + + EE A+ K ++
Sbjct: 2349 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2380
Score = 62.4 bits (150), Expect = 1e-09
Identities = 89/400 (22%), Positives = 166/400 (41%), Gaps = 36/400 (9%)
Query: 36 RRRARQERLRQKQ---EEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE 92
RR +ERL ++Q E E L +V +E Q + +AK E E
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--E 1367
Query: 93 RLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE 152
+ RREE Q+ Q+E + + ++ Q + AE EE E R
Sbjct: 1368 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE--EIRVV 1425
Query: 153 RYEIEETETVT--KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDE-KIKK 209
R ++E TE + R E + K + +EE E+ +R E+Q K + +++
Sbjct: 1426 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1485
Query: 210 DKEPKEEVKSFMDRKKGFTEVKS--QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAP 267
K E ++ ++++ ++ E +L+ E +R + V + A+ +
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETAQRSA 1542
Query: 268 QVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQ 327
+ E + +R ++ + E+ Q++ A +L E E R+ ++ E R +
Sbjct: 1543 EAEL-----QSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAERAR 1592
Query: 328 EEADRKLR----EEEEKRRLK---EEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 380
EEA+R+L + E RL+ EE+ ++++ A + +K E+ + ++ K +
Sbjct: 1593 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA---EE 1649
Query: 381 SSLKIEERAE-FLNKSVQKSSGVKSTHQAAIVSKIDSRLE 419
+++ E AE L K Q + G AA I R E
Sbjct: 1650 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1689
Score = 60.1 bits (144), Expect = 5e-09
Identities = 68/343 (19%), Positives = 156/343 (45%), Gaps = 42/343 (12%)
Query: 29 EEAARERRRR----ARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEG 84
+EAAR R+ A+Q L +K +E + V + + A+ + ++ + +
Sbjct: 2256 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2315
Query: 85 DDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKE 144
+D+ ++LA + Q+ L+ ERQ++ + + L L M A E +
Sbjct: 2316 EDKEQMAQQLAEETQGFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2373
Query: 145 EKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD 204
+ ++ + ++ TE T+ + E + ++ + + + R +I E + +
Sbjct: 2374 FRKQAEEIGEKLHRTELATQE------KVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2427
Query: 205 EKIKKDK---EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK 261
EK++++ + K E + +++ E ++ F++ K ++ R ++ +
Sbjct: 2428 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK----DSLLQR---ERFIEQE 2480
Query: 262 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 321
+A +LE+L + E + ++L+++QQ ++E+ E +R V E
Sbjct: 2481 KA----------KLEQLF----QDEVAKAQQLREEQQRQQQQMEQ-----ERQRLVASME 2521
Query: 322 EQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMPE 363
E RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++ E
Sbjct: 2522 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2564
Score = 31.6 bits (70), Expect = 1.9
Identities = 28/124 (22%), Positives = 50/124 (40%), Gaps = 10/124 (8%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
++E A+ ++ R Q+R +Q+ E+E V E + +E + Q
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2548
Query: 88 AAFLERLARREERRQKRLQ-------EALERQKEFDPTITDASLSLPSRRMQNDTAENET 140
E LA +R +++LQ AL +E + A+ +LP+ R D +
Sbjct: 2549 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPA 2605
Query: 141 TEKE 144
E E
Sbjct: 2606 AEAE 2609
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 77.4 bits (189), Expect = 3e-14
Identities = 100/425 (23%), Positives = 174/425 (40%), Gaps = 77/425 (18%)
Query: 2 LGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQK--QEEESLGQVTDQ 59
LG S+ +L + Q + + A ERRRR +ER+++ EEE+ Q
Sbjct: 2085 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2144
Query: 60 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ--------EALER 111
+E + EEA+ + E +L +E QKRLQ ++
Sbjct: 2145 LEEVERLKAKVEEARRLRERAEQES------ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198
Query: 112 QKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSY 166
++E T+ L R + + A E EE + E+ Q R ++EE E + +S
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2258
Query: 167 QKNDWRDAEENKKEDKEKEEEEEEKPKR-----GSIGENQIKDEKIKKDKEPKEEVKSFM 221
++ A+ +K ++E E+E +R ++ + Q D +++K K+ E+
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--- 2315
Query: 222 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD-TKEAEGAPQVE-----AGKRL 275
R+K E + + H +N R + T+ A QVE ++
Sbjct: 2316 -RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2374
Query: 276 EELRRRRGETES------------------EEFEKLKQKQQEAA--------------LE 303
EEL + + E+ EE EK+KQ +EAA L
Sbjct: 2375 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2434
Query: 304 LEELKKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEA 354
E+L ++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ +
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494
Query: 355 AEKRQ 359
AE+ Q
Sbjct: 2495 AEETQ 2499
Score = 74.3 bits (181), Expect = 3e-13
Identities = 107/454 (23%), Positives = 203/454 (44%), Gaps = 63/454 (13%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV---- 82
EEE AR +R A + RQ+ E E L +V ++EV A + +EE+++T+ ++
Sbjct: 1870 EEELARLQREAAAATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928
Query: 83 ------EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 136
E +EAA L LA +R+++ +E RQ+ + L+ + T
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT- 1987
Query: 137 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 196
E E KE+++E+ + R E+ +++Q+ R EE + K EE + ++ S
Sbjct: 1988 EAEIALKEKEAENERLRRLAED-----EAFQR---RRLEEQAAQHKADIEERLAQLRKAS 2039
Query: 197 IGENQ----IKDEKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 248
E + + ++ +++ ++ +EE+ SF G E++ + G + + E+T
Sbjct: 2040 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS----NAEDT 2095
Query: 249 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGE---TESEEFEKLKQKQQEAAL-EL 304
S + E E A Q + EE RRR E +S E+ +Q++AAL E+
Sbjct: 2096 L------RSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148
Query: 305 EELKKKREERRKVLEEEEQ------RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKR 358
E LK K EE R++ E EQ + QE A ++L+ EE+ + + + + ++
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208
Query: 359 QKMPEDGLSDDKKPFKCFTPKGSSLKIE------------ERAEFLNKSVQKSSGVKSTH 406
++ D L + + + + +++ E AE L +S ++ + ++
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2268
Query: 407 QAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 440
QAA K+ EQ + + A + A+D
Sbjct: 2269 QAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301
Score = 73.2 bits (178), Expect = 6e-13
Identities = 98/397 (24%), Positives = 165/397 (41%), Gaps = 52/397 (13%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
EE A++R+ + ERLR++ ++ES + +VE+ ++ E A+ Q
Sbjct: 1620 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA----- 1674
Query: 88 AAFLERLARREERRQKRLQEA-LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEK 146
LE L + E ++RL++A +ER ++ + A S + + E T + E+
Sbjct: 1675 ---LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1731
Query: 147 SESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEK 206
S ++E ++ R A++ + ++ +EE E E + Q+K +
Sbjct: 1732 S--------LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW------QLKANE 1777
Query: 207 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 266
+ + EEV + E + + E + E R A + ++
Sbjct: 1778 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1837
Query: 267 PQVEAGKRL---EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKK 310
+ A +RL +EL R R ETE E E+L + Q+EAA ELE EL K
Sbjct: 1838 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1897
Query: 311 REERR-----KVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKM 361
R E K EEE R E++ ++L E + R L EE R RA EA +RQ
Sbjct: 1898 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1957
Query: 362 PEDGLSDDKKPFKCFTPK----GSSLKIEERAEFLNK 394
ED + + K G + +++ AE K
Sbjct: 1958 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1994
Score = 72.0 bits (175), Expect = 1e-12
Identities = 90/429 (20%), Positives = 174/429 (40%), Gaps = 35/429 (8%)
Query: 13 LAALSQIAYQRNDDDEEEAARERRRR--ARQERLRQKQ-EEESLGQVTDQVEVNAQNSVP 69
+A +A + +EEA RE RRR A ++ +RQ++ E+ L + E AQ +
Sbjct: 1788 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1847
Query: 70 DEEAKTTTTNTQVEGDDEAAFL-ERLARREERRQKRLQEALERQKEFDPTITDASLSLPS 128
E+ +G+ + L E LAR + Q+ E + E + + L S
Sbjct: 1848 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1907
Query: 129 RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 188
+ + + + + + +++ E+ R+ E + + + +ED ++ E
Sbjct: 1908 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1967
Query: 189 EEK---PKRGSIGE-NQIKDEK--IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL 242
E+ K +IGE ++K E K+KE + E + + F + + + HK
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKA 2026
Query: 243 KHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETE-----SEEFEKLKQKQ 297
E R + K ++ + + G + LR+RR E FEK +
Sbjct: 2027 DIEE--------RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 2078
Query: 298 QEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 357
E LEL ++ E+ L +EQ + R+L EEE+RR + E +++ AAE+
Sbjct: 2079 AELELELGRIRSNAED---TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2135
Query: 358 RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSR 417
++ + K K+EE ++ Q+S+ Q A ++ +
Sbjct: 2136 EAARQRKAALEEVERLKA--------KVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187
Query: 418 LEQYTSAIE 426
+ + A++
Sbjct: 2188 EKAHAFAVQ 2196
Score = 70.5 bits (171), Expect = 4e-12
Identities = 85/403 (21%), Positives = 171/403 (42%), Gaps = 44/403 (10%)
Query: 6 GSHGR-RSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNA 64
G+ G ++L A ++ A + +EEA R RR+ + + +++ E E +V + E
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1666
Query: 65 QNS----------VPDEEAKTTTTNTQVEGDDEAAFLERLARR--EERRQKRLQEALERQ 112
+ + EEA+ +VE + A+R E Q + E+
Sbjct: 1667 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1726
Query: 113 KEFDPTITDASLSLPSRRMQNDTAENETTEKE---EKSESRQERYEIEETETVTKSYQKN 169
+ + ++ + +++ R + + + E E E++E ER++++ E + Q
Sbjct: 1727 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786
Query: 170 DWRDAEE--NKKEDKEKEEEEEEKPKRG-----SIGENQIKDEKIKKDKEPKE------- 215
+ + + +K+KEE E E +RG ++ + ++ +++++K ++ E
Sbjct: 1787 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1846
Query: 216 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVDTKEAEGAPQVE 270
+ + R + TE Q + + +L + T R A + AE +
Sbjct: 1847 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1906
Query: 271 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE--RRKVLEEEEQRRKQE 328
+ R EE R E + E + +E A E L+ EE R++ L EE+ R++
Sbjct: 1907 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1966
Query: 329 EADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 364
EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009
Score = 65.5 bits (158), Expect = 1e-10
Identities = 85/391 (21%), Positives = 157/391 (40%), Gaps = 66/391 (16%)
Query: 29 EEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQV---EGD 85
EEAAR R +R RQ EE++ Q + V A+ EA T ++ E +
Sbjct: 1938 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1997
Query: 86 DEAAFLERLARREERRQKRLQE-ALERQKEFDPTI------TDASLSLPSRRMQNDTAEN 138
E L RLA E +++RL+E A + + + + + +D+ L +++ +
Sbjct: 1998 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057
Query: 139 ETTEKE--------EKSESRQERYEIE------ETETVTKSYQKNDWRDAEENK---KED 181
E+E EK+ + + E+E E +S ++ + A + + +E+
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117
Query: 182 KEKEEEEEEKPKRGSIGENQIKD-----EKIKKDKEPKEEVKSFMDR------------- 223
+ + E EE K + E + E++++ K EE + +R
Sbjct: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177
Query: 224 ----------KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK 273
+K Q + + L+ ++ + G A + AE A +
Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2237
Query: 274 RLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRK 333
E + RR + EE E+LKQ +E A + + E+ RK E+E RR Q E
Sbjct: 2238 EREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE-QAA 2293
Query: 334 LR-------EEEEKRRLKEEIERRRAEAAEK 357
LR E E+ ++ E+ R++A+ ++
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2324
Score = 63.9 bits (154), Expect = 3e-10
Identities = 90/420 (21%), Positives = 175/420 (41%), Gaps = 58/420 (13%)
Query: 38 RARQERLRQKQ----EEESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAF 90
+A +E+LRQ+Q E E G+ ++ + A+ N++ D E + T Q+E A
Sbjct: 1379 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVAS 1435
Query: 91 LERLARREERRQKRLQEALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEE 145
+ + + + +QE ++ + + T S +S RRM+ E E +++
Sbjct: 1436 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQ 1491
Query: 146 KSESRQERYEIE---ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
++E R+ E+E E + AE KE +++ +EE + + ++ Q
Sbjct: 1492 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1551
Query: 203 KD------EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA 256
K +++++ E + + K+ + ++ + E +L+ R G
Sbjct: 1552 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-EIRVVRLQLEATERQRGGAEG 1610
Query: 257 SVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 314
+ A A + EA KR EE R R + + E K + + + A+ E + RE++
Sbjct: 1611 ELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1669
Query: 315 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 374
R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------- 1716
Query: 375 CFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSAK 432
+RA F K+ Q ++ H A + + + R +Q A + A+
Sbjct: 1717 -----------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1765
Score = 63.9 bits (154), Expect = 3e-10
Identities = 82/392 (20%), Positives = 167/392 (42%), Gaps = 26/392 (6%)
Query: 16 LSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQVTDQVEVNAQNSVPDEEAK 74
L+Q A Q+ EE+A ++ QE + Q+E+S L Q+ + E + + EEA+
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2234
Query: 75 TTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALERQKEFDPTITDASLSLPS 128
+ + ERL + EE+ Q R Q E L ++ E + +
Sbjct: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294
Query: 129 RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 188
R+ Q AE E +K + RQ+ +E T+ ++ D + +++ + K E
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2354
Query: 189 EEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 248
E +R + E ++ +++ ++ K + + + + K F+ + + +
Sbjct: 2355 EAARQRSQV-EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2413
Query: 249 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELK 308
+ R SV +EA Q+ E+L ++R EK+ +++ +A E LK
Sbjct: 2414 -AEEAARLSVAAQEAARLRQLAE----EDLAQQRALA-----EKMLKEKMQAVQEATRLK 2463
Query: 309 KKRE--ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGL 366
+ E +++K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E
Sbjct: 2464 AEAELLQQQKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2517
Query: 367 SDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 398
++ + + + EE A+ K ++
Sbjct: 2518 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549
Score = 62.4 bits (150), Expect = 1e-09
Identities = 89/400 (22%), Positives = 166/400 (41%), Gaps = 36/400 (9%)
Query: 36 RRRARQERLRQKQ---EEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE 92
RR +ERL ++Q E E L +V +E Q + +AK E E
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--E 1536
Query: 93 RLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE 152
+ RREE Q+ Q+E + + ++ Q + AE EE E R
Sbjct: 1537 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE--EIRVV 1594
Query: 153 RYEIEETETVT--KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDE-KIKK 209
R ++E TE + R E + K + +EE E+ +R E+Q K + +++
Sbjct: 1595 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1654
Query: 210 DKEPKEEVKSFMDRKKGFTEVKS--QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAP 267
K E ++ ++++ ++ E +L+ E +R + V + A+ +
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETAQRSA 1711
Query: 268 QVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQ 327
+ E + +R ++ + E+ Q++ A +L E E R+ ++ E R +
Sbjct: 1712 EAEL-----QSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAERAR 1761
Query: 328 EEADRKLR----EEEEKRRLK---EEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 380
EEA+R+L + E RL+ EE+ ++++ A + +K E+ + ++ K +
Sbjct: 1762 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA---EE 1818
Query: 381 SSLKIEERAE-FLNKSVQKSSGVKSTHQAAIVSKIDSRLE 419
+++ E AE L K Q + G AA I R E
Sbjct: 1819 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1858
Score = 60.1 bits (144), Expect = 5e-09
Identities = 68/343 (19%), Positives = 156/343 (45%), Gaps = 42/343 (12%)
Query: 29 EEAARERRRR----ARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEG 84
+EAAR R+ A+Q L +K +E + V + + A+ + ++ + +
Sbjct: 2425 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2484
Query: 85 DDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKE 144
+D+ ++LA + Q+ L+ ERQ++ + + L L M A E +
Sbjct: 2485 EDKEQMAQQLAEETQGFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2542
Query: 145 EKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD 204
+ ++ + ++ TE T+ + E + ++ + + + R +I E + +
Sbjct: 2543 FRKQAEEIGEKLHRTELATQE------KVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2596
Query: 205 EKIKKDK---EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK 261
EK++++ + K E + +++ E ++ F++ K ++ R ++ +
Sbjct: 2597 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK----DSLLQR---ERFIEQE 2649
Query: 262 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 321
+A +LE+L + E + ++L+++QQ ++E+ E +R V E
Sbjct: 2650 KA----------KLEQLF----QDEVAKAQQLREEQQRQQQQMEQ-----ERQRLVASME 2690
Query: 322 EQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMPE 363
E RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++ E
Sbjct: 2691 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2733
Score = 31.6 bits (70), Expect = 1.9
Identities = 28/124 (22%), Positives = 50/124 (40%), Gaps = 10/124 (8%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
++E A+ ++ R Q+R +Q+ E+E V E + +E + Q
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2717
Query: 88 AAFLERLARREERRQKRLQ-------EALERQKEFDPTITDASLSLPSRRMQNDTAENET 140
E LA +R +++LQ AL +E + A+ +LP+ R D +
Sbjct: 2718 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPA 2774
Query: 141 TEKE 144
E E
Sbjct: 2775 AEAE 2778
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 77.4 bits (189), Expect = 3e-14
Identities = 100/425 (23%), Positives = 174/425 (40%), Gaps = 77/425 (18%)
Query: 2 LGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQK--QEEESLGQVTDQ 59
LG S+ +L + Q + + A ERRRR +ER+++ EEE+ Q
Sbjct: 1926 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1985
Query: 60 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ--------EALER 111
+E + EEA+ + E +L +E QKRLQ ++
Sbjct: 1986 LEEVERLKAKVEEARRLRERAEQES------ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039
Query: 112 QKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-----KSESRQERYEIEETETVTKSY 166
++E T+ L R + + A E EE + E+ Q R ++EE E + +S
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2099
Query: 167 QKNDWRDAEENKKEDKEKEEEEEEKPKR-----GSIGENQIKDEKIKKDKEPKEEVKSFM 221
++ A+ +K ++E E+E +R ++ + Q D +++K K+ E+
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--- 2156
Query: 222 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD-TKEAEGAPQVE-----AGKRL 275
R+K E + + H +N R + T+ A QVE ++
Sbjct: 2157 -RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2215
Query: 276 EELRRRRGETES------------------EEFEKLKQKQQEAA--------------LE 303
EEL + + E+ EE EK+KQ +EAA L
Sbjct: 2216 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2275
Query: 304 LEELKKKREERRKVLEE-----EEQRRKQEEAD----RKLREEEEKRRLKEEIERRRAEA 354
E+L ++R K+L+E +E R + EA+ +K +E+ RRL+E+ E+ +
Sbjct: 2276 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335
Query: 355 AEKRQ 359
AE+ Q
Sbjct: 2336 AEETQ 2340
Score = 74.3 bits (181), Expect = 3e-13
Identities = 107/454 (23%), Positives = 203/454 (44%), Gaps = 63/454 (13%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV---- 82
EEE AR +R A + RQ+ E E L +V ++EV A + +EE+++T+ ++
Sbjct: 1711 EEELARLQREAAAATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
Query: 83 ------EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 136
E +EAA L LA +R+++ +E RQ+ + L+ + T
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT- 1828
Query: 137 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 196
E E KE+++E+ + R E+ +++Q+ R EE + K EE + ++ S
Sbjct: 1829 EAEIALKEKEAENERLRRLAED-----EAFQR---RRLEEQAAQHKADIEERLAQLRKAS 1880
Query: 197 IGENQ----IKDEKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 248
E + + ++ +++ ++ +EE+ SF G E++ + G + + E+T
Sbjct: 1881 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS----NAEDT 1936
Query: 249 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGE---TESEEFEKLKQKQQEAAL-EL 304
S + E E A Q + EE RRR E +S E+ +Q++AAL E+
Sbjct: 1937 L------RSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989
Query: 305 EELKKKREERRKVLEEEEQ------RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKR 358
E LK K EE R++ E EQ + QE A ++L+ EE+ + + + + ++
Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2049
Query: 359 QKMPEDGLSDDKKPFKCFTPKGSSLKIE------------ERAEFLNKSVQKSSGVKSTH 406
++ D L + + + + +++ E AE L +S ++ + ++
Sbjct: 2050 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2109
Query: 407 QAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 440
QAA K+ EQ + + A + A+D
Sbjct: 2110 QAA-AEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142
Score = 73.2 bits (178), Expect = 6e-13
Identities = 98/397 (24%), Positives = 165/397 (41%), Gaps = 52/397 (13%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
EE A++R+ + ERLR++ ++ES + +VE+ ++ E A+ Q
Sbjct: 1461 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA----- 1515
Query: 88 AAFLERLARREERRQKRLQEA-LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEK 146
LE L + E ++RL++A +ER ++ + A S + + E T + E+
Sbjct: 1516 ---LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1572
Query: 147 SESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEK 206
S ++E ++ R A++ + ++ +EE E E + Q+K +
Sbjct: 1573 S--------LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW------QLKANE 1618
Query: 207 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 266
+ + EEV + E + + E + E R A + ++
Sbjct: 1619 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1678
Query: 267 PQVEAGKRL---EELRRRRGETESEE------FEKLKQKQQEAAL------ELE-ELKKK 310
+ A +RL +EL R R ETE E E+L + Q+EAA ELE EL K
Sbjct: 1679 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1738
Query: 311 REERR-----KVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRA---EAAEKRQKM 361
R E K EEE R E++ ++L E + R L EE R RA EA +RQ
Sbjct: 1739 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1798
Query: 362 PEDGLSDDKKPFKCFTPK----GSSLKIEERAEFLNK 394
ED + + K G + +++ AE K
Sbjct: 1799 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1835
Score = 72.0 bits (175), Expect = 1e-12
Identities = 90/429 (20%), Positives = 174/429 (40%), Gaps = 35/429 (8%)
Query: 13 LAALSQIAYQRNDDDEEEAARERRRR--ARQERLRQKQ-EEESLGQVTDQVEVNAQNSVP 69
+A +A + +EEA RE RRR A ++ +RQ++ E+ L + E AQ +
Sbjct: 1629 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1688
Query: 70 DEEAKTTTTNTQVEGDDEAAFL-ERLARREERRQKRLQEALERQKEFDPTITDASLSLPS 128
E+ +G+ + L E LAR + Q+ E + E + + L S
Sbjct: 1689 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1748
Query: 129 RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 188
+ + + + + + +++ E+ R+ E + + + +ED ++ E
Sbjct: 1749 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1808
Query: 189 EEK---PKRGSIGE-NQIKDEK--IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL 242
E+ K +IGE ++K E K+KE + E + + F + + + HK
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKA 1867
Query: 243 KHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETE-----SEEFEKLKQKQ 297
E R + K ++ + + G + LR+RR E FEK +
Sbjct: 1868 DIEE--------RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1919
Query: 298 QEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 357
E LEL ++ E+ L +EQ + R+L EEE+RR + E +++ AAE+
Sbjct: 1920 AELELELGRIRSNAED---TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1976
Query: 358 RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSR 417
++ + K K+EE ++ Q+S+ Q A ++ +
Sbjct: 1977 EAARQRKAALEEVERLKA--------KVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028
Query: 418 LEQYTSAIE 426
+ + A++
Sbjct: 2029 EKAHAFAVQ 2037
Score = 70.5 bits (171), Expect = 4e-12
Identities = 85/403 (21%), Positives = 171/403 (42%), Gaps = 44/403 (10%)
Query: 6 GSHGR-RSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNA 64
G+ G ++L A ++ A + +EEA R RR+ + + +++ E E +V + E
Sbjct: 1448 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1507
Query: 65 QNS----------VPDEEAKTTTTNTQVEGDDEAAFLERLARR--EERRQKRLQEALERQ 112
+ + EEA+ +VE + A+R E Q + E+
Sbjct: 1508 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1567
Query: 113 KEFDPTITDASLSLPSRRMQNDTAENETTEKE---EKSESRQERYEIEETETVTKSYQKN 169
+ + ++ + +++ R + + + E E E++E ER++++ E + Q
Sbjct: 1568 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627
Query: 170 DWRDAEE--NKKEDKEKEEEEEEKPKRG-----SIGENQIKDEKIKKDKEPKE------- 215
+ + + +K+KEE E E +RG ++ + ++ +++++K ++ E
Sbjct: 1628 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1687
Query: 216 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVDTKEAEGAPQVE 270
+ + R + TE Q + + +L + T R A + AE +
Sbjct: 1688 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1747
Query: 271 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE--RRKVLEEEEQRRKQE 328
+ R EE R E + E + +E A E L+ EE R++ L EE+ R++
Sbjct: 1748 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1807
Query: 329 EADRKLREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 364
EA+R L E+ E RLK E E + + E+ +++ ED
Sbjct: 1808 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850
Score = 65.5 bits (158), Expect = 1e-10
Identities = 85/391 (21%), Positives = 157/391 (40%), Gaps = 66/391 (16%)
Query: 29 EEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQV---EGD 85
EEAAR R +R RQ EE++ Q + V A+ EA T ++ E +
Sbjct: 1779 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1838
Query: 86 DEAAFLERLARREERRQKRLQE-ALERQKEFDPTI------TDASLSLPSRRMQNDTAEN 138
E L RLA E +++RL+E A + + + + + +D+ L +++ +
Sbjct: 1839 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898
Query: 139 ETTEKE--------EKSESRQERYEIE------ETETVTKSYQKNDWRDAEENK---KED 181
E+E EK+ + + E+E E +S ++ + A + + +E+
Sbjct: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958
Query: 182 KEKEEEEEEKPKRGSIGENQIKD-----EKIKKDKEPKEEVKSFMDR------------- 223
+ + E EE K + E + E++++ K EE + +R
Sbjct: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
Query: 224 ----------KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK 273
+K Q + + L+ ++ + G A + AE A +
Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2078
Query: 274 RLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRK 333
E + RR + EE E+LKQ +E A + + E+ RK E+E RR Q E
Sbjct: 2079 EREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE-QAA 2134
Query: 334 LR-------EEEEKRRLKEEIERRRAEAAEK 357
LR E E+ ++ E+ R++A+ ++
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2165
Score = 63.9 bits (154), Expect = 3e-10
Identities = 90/420 (21%), Positives = 175/420 (41%), Gaps = 58/420 (13%)
Query: 38 RARQERLRQKQ----EEESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAF 90
+A +E+LRQ+Q E E G+ ++ + A+ N++ D E + T Q+E A
Sbjct: 1220 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVAS 1276
Query: 91 LERLARREERRQKRLQEALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEE 145
+ + + + +QE ++ + + T S +S RRM+ E E +++
Sbjct: 1277 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQ 1332
Query: 146 KSESRQERYEIE---ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 202
++E R+ E+E E + AE KE +++ +EE + + ++ Q
Sbjct: 1333 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1392
Query: 203 KD------EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA 256
K +++++ E + + K+ + ++ + E +L+ R G
Sbjct: 1393 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-EIRVVRLQLEATERQRGGAEG 1451
Query: 257 SVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 314
+ A A + EA KR EE R R + + E K + + + A+ E + RE++
Sbjct: 1452 ELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1510
Query: 315 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 374
R + EE R + EEA+R+LR+ E +R + ++ A E Q+ E L
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAEVERARQVQV------ALETAQRSAEAELQ------- 1557
Query: 375 CFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSAK 432
+RA F K+ Q ++ H A + + + R +Q A + A+
Sbjct: 1558 -----------SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1606
Score = 63.9 bits (154), Expect = 3e-10
Identities = 82/392 (20%), Positives = 167/392 (42%), Gaps = 26/392 (6%)
Query: 16 LSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQVTDQVEVNAQNSVPDEEAK 74
L+Q A Q+ EE+A ++ QE + Q+E+S L Q+ + E + + EEA+
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2075
Query: 75 TTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALERQKEFDPTITDASLSLPS 128
+ + ERL + EE+ Q R Q E L ++ E + +
Sbjct: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135
Query: 129 RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 188
R+ Q AE E +K + RQ+ +E T+ ++ D + +++ + K E
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2195
Query: 189 EEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 248
E +R + E ++ +++ ++ K + + + + K F+ + + +
Sbjct: 2196 EAARQRSQV-EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2254
Query: 249 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELK 308
+ R SV +EA Q+ E+L ++R EK+ +++ +A E LK
Sbjct: 2255 -AEEAARLSVAAQEAARLRQLAE----EDLAQQRALA-----EKMLKEKMQAVQEATRLK 2304
Query: 309 KKRE--ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGL 366
+ E +++K L +E+ RR QE+ +E+ ++L EE + + +RQ+ E
Sbjct: 2305 AEAELLQQQKELAQEQARRLQED------KEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2358
Query: 367 SDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 398
++ + + + EE A+ K ++
Sbjct: 2359 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390
Score = 62.4 bits (150), Expect = 1e-09
Identities = 89/400 (22%), Positives = 166/400 (41%), Gaps = 36/400 (9%)
Query: 36 RRRARQERLRQKQ---EEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE 92
RR +ERL ++Q E E L +V +E Q + +AK E E
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--E 1377
Query: 93 RLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE 152
+ RREE Q+ Q+E + + ++ Q + AE EE E R
Sbjct: 1378 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE--EIRVV 1435
Query: 153 RYEIEETETVT--KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDE-KIKK 209
R ++E TE + R E + K + +EE E+ +R E+Q K + +++
Sbjct: 1436 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495
Query: 210 DKEPKEEVKSFMDRKKGFTEVKS--QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAP 267
K E ++ ++++ ++ E +L+ E +R + V + A+ +
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETAQRSA 1552
Query: 268 QVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQ 327
+ E + +R ++ + E+ Q++ A +L E E R+ ++ E R +
Sbjct: 1553 EAEL-----QSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAERAR 1602
Query: 328 EEADRKLR----EEEEKRRLK---EEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 380
EEA+R+L + E RL+ EE+ ++++ A + +K E+ + ++ K +
Sbjct: 1603 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA---EE 1659
Query: 381 SSLKIEERAE-FLNKSVQKSSGVKSTHQAAIVSKIDSRLE 419
+++ E AE L K Q + G AA I R E
Sbjct: 1660 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1699
Score = 60.1 bits (144), Expect = 5e-09
Identities = 68/343 (19%), Positives = 156/343 (45%), Gaps = 42/343 (12%)
Query: 29 EEAARERRRR----ARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEG 84
+EAAR R+ A+Q L +K +E + V + + A+ + ++ + +
Sbjct: 2266 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2325
Query: 85 DDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKE 144
+D+ ++LA + Q+ L+ ERQ++ + + L L M A E +
Sbjct: 2326 EDKEQMAQQLAEETQGFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2383
Query: 145 EKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD 204
+ ++ + ++ TE T+ + E + ++ + + + R +I E + +
Sbjct: 2384 FRKQAEEIGEKLHRTELATQE------KVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2437
Query: 205 EKIKKDK---EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK 261
EK++++ + K E + +++ E ++ F++ K ++ R ++ +
Sbjct: 2438 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK----DSLLQR---ERFIEQE 2490
Query: 262 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 321
+A +LE+L + E + ++L+++QQ ++E+ E +R V E
Sbjct: 2491 KA----------KLEQLF----QDEVAKAQQLREEQQRQQQQMEQ-----ERQRLVASME 2531
Query: 322 EQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMPE 363
E RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++ E
Sbjct: 2532 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2574
Score = 31.6 bits (70), Expect = 1.9
Identities = 28/124 (22%), Positives = 50/124 (40%), Gaps = 10/124 (8%)
Query: 28 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 87
++E A+ ++ R Q+R +Q+ E+E V E + +E + Q
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2558
Query: 88 AAFLERLARREERRQKRLQ-------EALERQKEFDPTITDASLSLPSRRMQNDTAENET 140
E LA +R +++LQ AL +E + A+ +LP+ R D +
Sbjct: 2559 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPA 2615
Query: 141 TEKE 144
E E
Sbjct: 2616 AEAE 2619
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.302 0.122 0.319
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,653,796
Number of Sequences: 37866
Number of extensions: 1224371
Number of successful extensions: 54144
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1198
Number of HSP's successfully gapped in prelim test: 1510
Number of HSP's that attempted gapping in prelim test: 9384
Number of HSP's gapped (non-prelim): 15376
length of query: 532
length of database: 18,247,518
effective HSP length: 107
effective length of query: 425
effective length of database: 14,195,856
effective search space: 6033238800
effective search space used: 6033238800
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.