Search of human proteins with 109809759

Search of human proteins with 109809759

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
sapiens]
         (581 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ...  1167   0.0  
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor...   705   0.0  
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor...   671   0.0  
gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo s...   481   e-135
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa...   437   e-122
gi|194440719 chondroadherin-like [Homo sapiens]                       130   3e-30
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   126   6e-29
gi|51317373 netrin-G1 ligand [Homo sapiens]                           123   5e-28
gi|153251229 chondroadherin precursor [Homo sapiens]                  122   7e-28
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]               121   2e-27
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   119   6e-27
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   119   6e-27
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre...   116   5e-26
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec...   116   5e-26
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...   116   6e-26
gi|157694513 leucine-rich repeat-containing G protein-coupled re...   115   8e-26
gi|198041768 synleurin [Homo sapiens]                                 115   1e-25
gi|12007646 nyctalopin precursor [Homo sapiens]                       112   7e-25
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo...   112   1e-24
gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]        112   1e-24
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom...   111   2e-24
gi|225579152 insulin-like growth factor binding protein, acid la...   111   2e-24
gi|4826772 insulin-like growth factor binding protein, acid labi...   111   2e-24
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]             111   2e-24
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]             111   2e-24
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]         110   4e-24
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]            110   5e-24
gi|62912470 leucine-rich repeat-containing G protein-coupled rec...   110   5e-24
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...   109   8e-24
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]            109   8e-24

>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
           sapiens]
          Length = 581

 Score = 1167 bits (3018), Expect = 0.0
 Identities = 581/581 (100%), Positives = 581/581 (100%)

Query: 1   MGFNVIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSIS 60
           MGFNVIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSIS
Sbjct: 1   MGFNVIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSIS 60

Query: 61  AGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNR 120
           AGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNR
Sbjct: 61  AGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNR 120

Query: 121 ISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDC 180
           ISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDC
Sbjct: 121 ISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDC 180

Query: 181 RNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNK 240
           RNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNK
Sbjct: 181 RNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNK 240

Query: 241 ISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDS 300
           ISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDS
Sbjct: 241 ISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDS 300

Query: 301 WISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSI 360
           WISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSI
Sbjct: 301 WISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSI 360

Query: 361 CGKSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEPGPETDADAEHISFHKI 420
           CGKSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEPGPETDADAEHISFHKI
Sbjct: 361 CGKSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEPGPETDADAEHISFHKI 420

Query: 421 IAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSLKQMTPSTQEFY 480
           IAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSLKQMTPSTQEFY
Sbjct: 421 IAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSLKQMTPSTQEFY 480

Query: 481 VDYKPTNTETSEMLLNGTGPCTYNKSGSRECEIPLSMNVSTFLAYDQPTISYCGVHHELL 540
           VDYKPTNTETSEMLLNGTGPCTYNKSGSRECEIPLSMNVSTFLAYDQPTISYCGVHHELL
Sbjct: 481 VDYKPTNTETSEMLLNGTGPCTYNKSGSRECEIPLSMNVSTFLAYDQPTISYCGVHHELL 540

Query: 541 SHKSFETNAQEDTMETHLETELDLSTITTAGRISDHKQQLA 581
           SHKSFETNAQEDTMETHLETELDLSTITTAGRISDHKQQLA
Sbjct: 541 SHKSFETNAQEDTMETHLETELDLSTITTAGRISDHKQQLA 581


>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
           [Homo sapiens]
          Length = 590

 Score =  705 bits (1819), Expect = 0.0
 Identities = 354/583 (60%), Positives = 437/583 (74%), Gaps = 17/583 (2%)

Query: 1   MGFNVIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSIS 60
           MGF++I  L G +V LV+ PT+LL ML+ A+R CPK CRC+GK+VYCES    +IP +IS
Sbjct: 1   MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS 60

Query: 61  AGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNR 120
            G  GLSLR+NS+QKLK NQF GLNQL WLYLDHN+IS++DE+AF GIRRLKELILSSN+
Sbjct: 61  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120

Query: 121 ISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDC 180
           I+Y  N TF PV NLRNLDLSYN+L +L SEQF+GLRKL+ LHLRSNSL+T+P+R+FQDC
Sbjct: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180

Query: 181 RNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNK 240
           RNL+ LDLGYNR+RSL+RN FAG+++LKELHLEHNQFSK+N A FPRL +L+++YLQWN+
Sbjct: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240

Query: 241 ISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDS 300
           I  I Q ++WTWSSL  LDLSGN+I+    P  F+C+PNLQ+LNLDSNKLT I QE +++
Sbjct: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIE-PGTFKCLPNLQKLNLDSNKLTNISQETVNA 299

Query: 301 WISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSI 360
           WISL  I+L+GN+WECSR+IC L  WLK+FKG +E+T+ICA PK +QG  V DAV+ Y+I
Sbjct: 300 WISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNI 359

Query: 361 CGK---STTERFDLA-------RALPKPT-FKPKLPRPKHESKPPLPPTVGATEPGPETD 409
           C +     TER  L          +P+PT FKP + +   E+  P P   G   PG E  
Sbjct: 360 CSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSP---GFQIPGAE-- 414

Query: 410 ADAEHISFHKIIAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSL 469
            + EH+SFHKIIAGSVALFLSV +ILLVIYVSWKRYPASMKQLQQ SLM+R RKK R+S 
Sbjct: 415 QEYEHVSFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESE 474

Query: 470 KQMTPSTQEFYVDYKPTNTETSEMLLNGTGPCTYNKSGSRECEIPLSMNVSTFLAYDQPT 529
           +QM    QE+YVDYKPTN+ET ++ +NG+GPCTY  SGSRECE+P  M    + +YDQP 
Sbjct: 475 RQMNSPLQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEMPHHMKPLPYYSYDQPV 534

Query: 530 ISYCGVHHELLSHKSFETNAQEDTMETHLETELDLSTITTAGR 572
           I YC  H  L   K +ET + E      LE   D S I T  R
Sbjct: 535 IGYCQAHQPLHVTKGYETVSPEQDESPGLELGRDHSFIATIAR 577


>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
           [Homo sapiens]
          Length = 518

 Score =  671 bits (1732), Expect = 0.0
 Identities = 332/524 (63%), Positives = 411/524 (78%), Gaps = 17/524 (3%)

Query: 1   MGFNVIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSIS 60
           MGF++I  L G +V LV+ PT+LL ML+ A+R CPK CRC+GK+VYCES    +IP +IS
Sbjct: 1   MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS 60

Query: 61  AGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNR 120
            G  GLSLR+NS+QKLK NQF GLNQL WLYLDHN+IS++DE+AF GIRRLKELILSSN+
Sbjct: 61  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120

Query: 121 ISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDC 180
           I+Y  N TF PV NLRNLDLSYN+L +L SEQF+GLRKL+ LHLRSNSL+T+P+R+FQDC
Sbjct: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180

Query: 181 RNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNK 240
           RNL+ LDLGYNR+RSL+RN FAG+++LKELHLEHNQFSK+N A FPRL +L+++YLQWN+
Sbjct: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240

Query: 241 ISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDS 300
           I  I Q ++WTWSSL  LDLSGN+I+    P  F+C+PNLQ+LNLDSNKLT I QE +++
Sbjct: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIE-PGTFKCLPNLQKLNLDSNKLTNISQETVNA 299

Query: 301 WISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSI 360
           WISL  I+L+GN+WECSR+IC L  WLK+FKG +E+T+ICA PK +QG  V DAV+ Y+I
Sbjct: 300 WISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNI 359

Query: 361 CGK---STTERFDLA-------RALPKPT-FKPKLPRPKHESKPPLPPTVGATEPGPETD 409
           C +     TER  L          +P+PT FKP + +   E+  P P   G   PG E  
Sbjct: 360 CSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSP---GFQIPGAE-- 414

Query: 410 ADAEHISFHKIIAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSL 469
            + EH+SFHKIIAGSVALFLSV +ILLVIYVSWKRYPASMKQLQQ SLM+R RKK R+S 
Sbjct: 415 QEYEHVSFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESE 474

Query: 470 KQMTPSTQEFYVDYKPTNTETSEMLLNGTGPCTYNKSGSRECEI 513
           +QM    QE+YVDYKPTN+ET ++ +NG+GPCTY  SGSRECE+
Sbjct: 475 RQMNSPLQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEV 518


>gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
           sapiens]
          Length = 522

 Score =  481 bits (1237), Expect = e-135
 Identities = 246/521 (47%), Positives = 358/521 (68%), Gaps = 23/521 (4%)

Query: 5   VIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSISAGCL 64
           ++R  SG  + L+ A      ML +A  GCP+ CRCEG+++YCE+  L E P ++S G L
Sbjct: 13  LLRRPSGVVLCLLGA---CFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEAPHNLS-GLL 68

Query: 65  GLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYF 124
           GLSLRYNSL +L+  QF GL QLTWLYLDHNHI ++  +AF  +RR+KEL LSSN+I+  
Sbjct: 69  GLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQL 128

Query: 125 LNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLE 184
            N TFRP+ NLR++DLSYN+L +L  + F GLRKL +LH+R+N+++ +PVRIFQDCR+L+
Sbjct: 129 PNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLK 188

Query: 185 LLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVI 244
            LD+GYN+++SLARN FAG+ +L ELHLEHN   K+N A FPRL+SL +L L+ NK++++
Sbjct: 189 FLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIV 248

Query: 245 GQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISL 304
             ++ W W +L+++DLSGNEIE +  P VF+ VP+LQ L LDSN+LT+I   IL+SW SL
Sbjct: 249 VSSLDWVW-NLEKMDLSGNEIE-YMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSL 306

Query: 305 NDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSICG-- 362
             I+LAGN+W+C RN+C+L +WL +F+G  +  + CASP+  QG +V+DAV  + +C   
Sbjct: 307 TSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCEDG 366

Query: 363 ---------KSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEPGPETDADAE 413
                     + T R DL       T        +H+     P TV    PG E   +A 
Sbjct: 367 AEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFE-PATVAL--PGGEHAENA- 422

Query: 414 HISFHKIIAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSLKQMT 473
            +  HK++ G++AL  S L+++LV+YVSWK +PAS++QL+Q  + +R ++K++Q++ QM 
Sbjct: 423 -VQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQMA 481

Query: 474 P-STQEFYVDYKPTNTETSEMLLNGTGPCTYNKSGSRECEI 513
             S QE+YVDYKP + E + +++N  G CT ++  +RECE+
Sbjct: 482 AMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV 522


>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
           sapiens]
          Length = 516

 Score =  437 bits (1123), Expect = e-122
 Identities = 232/518 (44%), Positives = 334/518 (64%), Gaps = 7/518 (1%)

Query: 1   MGFNVIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSIS 60
           MG +    L    +A + A +++L ML +    CP  CRCE  + YC+SQ    +P++  
Sbjct: 1   MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATD 60

Query: 61  AGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNR 120
            G LGLSLR+N + +L+ +QF   +QLTWL+LDHN IS + E+AF G+ +LKELILSSN+
Sbjct: 61  KGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNK 120

Query: 121 ISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDC 180
           I Y  N TF  + NL+NLDLS+NQL SL  E F GLRKL +LHLRSNSLRTIPVR+F DC
Sbjct: 121 IFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDC 180

Query: 181 RNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNK 240
           R+LE LDL  NR+RSLARN FAG+I+L+ELHLEHNQ +K+N A F RL SL  L+LQWNK
Sbjct: 181 RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNK 240

Query: 241 ISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDS 300
           IS +   M WTW +L++LDL+GNEI+A    +VF+ +PNL+ L +D+NKL  +  +IL+S
Sbjct: 241 ISNLTCGMEWTWGTLEKLDLTGNEIKAID-LTVFETMPNLKILLMDNNKLNSLDSKILNS 299

Query: 301 WISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSI 360
             SL  + L+GN+WECS  IC+L +WL SF+G  E++I+C SP   QG +++DAV  + +
Sbjct: 300 LRSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQL 359

Query: 361 CGKSTTERFDLARALPKPT---FKPKLPRPKHESKPPLPPTVGATEPGPETDADAEHISF 417
           C   +T    +A     PT    K       H     +P T G      E   + ++  F
Sbjct: 360 CWNLSTTVTVMATTYRDPTTEYTKRISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIF 419

Query: 418 -HKIIAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQS-LKQMTPS 475
             ++I G++AL  S   I+ ++++S K  P ++++++Q S+++ HR+ + Q+ L     S
Sbjct: 420 TQRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLRSQTRLHMSNMS 479

Query: 476 TQEFYVDYKPTNTETSEMLLNGTGPCTYNKSGSRECEI 513
            Q  Y +Y+PT+ E   +++NG G C   +   +ECE+
Sbjct: 480 DQGPYNEYEPTH-EGPFIIINGYGQCKCQQLPYKECEV 516


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  130 bits (327), Expect = 3e-30
 Identities = 113/384 (29%), Positives = 172/384 (44%), Gaps = 14/384 (3%)

Query: 10  SGSAVALVIAPTVLLTML---SSAERGCPKGCRCEG--KMVYCESQKLQEIPSSISAGCL 64
           S + V LV+   VLL +     +A + CP+ C C+   + V C  Q L E+P +I     
Sbjct: 6   SSTHVPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQ 65

Query: 65  GLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYF 124
            L L+ N L+ +    F+G+  LT L L H  +  + E AF G+ RL  L L+SN +   
Sbjct: 66  RLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLREL 125

Query: 125 LNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLE 184
                  + +LR L+L  N L  L    F  L  L +L+L  N+L  +P   FQ    + 
Sbjct: 126 PQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVR 185

Query: 185 LLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVI 244
            L L +N +  LA    AG+  L+ L L HN+   L   +  +   L  L L  N ++  
Sbjct: 186 WLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYA 245

Query: 245 GQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISL 304
           G+        L+ L L G  ++A  GP  F   P L  L+L  N+L  +    L     L
Sbjct: 246 GEEDGLALPGLRELLLDGGALQAL-GPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQL 302

Query: 305 NDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSI-C-G 362
             + L GN   C      L+ WL   +   +    C  P+ L+G   +DA++ + + C G
Sbjct: 303 RRLRLQGNPLWCGCQARPLLEWLARARVRSDGA--CQGPRRLRG-EALDALRPWDLRCPG 359

Query: 363 KSTTERFDL-ARALPKPTFKPKLP 385
            +  E  +L  RA+  P   P+ P
Sbjct: 360 DAAQEEEELEERAVAGPRAPPRGP 383



 Score =  103 bits (256), Expect = 6e-22
 Identities = 91/331 (27%), Positives = 134/331 (40%), Gaps = 7/331 (2%)

Query: 34  CPKGCRC--EGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLY 91
           CP+ C C  E +   CE   LQ +P    +    L LR N    +    F GL  L  L+
Sbjct: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455

Query: 92  LDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSE 151
           L H  I+ ++  A  G+ RL  L LS N+++            L  L L  N+   +   
Sbjct: 456 LQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGA 515

Query: 152 QFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELH 211
             R L  L SLHL+ N++  +        R L  + L  NRI  ++         L++LH
Sbjct: 516 ALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLH 575

Query: 212 LEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQ-TMSWTWSSLQRLDLSGNEIEAFSG 270
           L+ NQ  ++       L +L  L L  N +  +          SLQ L L+ + +E    
Sbjct: 576 LDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICP 635

Query: 271 PSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSF 330
            +     P LQ L+L  N+L  +    L S   L  I L+ N + C   +  L  WL   
Sbjct: 636 GAFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGL 693

Query: 331 KGLRENTIICASPKELQGVNVIDAVKNYSIC 361
             LR     CA+P   +G  V  A   +  C
Sbjct: 694 -NLRVGA-TCATPPNARGQRVKAAAAVFEDC 722


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  126 bits (316), Expect = 6e-29
 Identities = 89/284 (31%), Positives = 141/284 (49%), Gaps = 2/284 (0%)

Query: 66  LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
           L L+ N LQ L    F+ L  L  L L  N ++ + E  F+ +  L+ L LS+N +S   
Sbjct: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP 209

Query: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
              F  + +L+ L L  N +  L  + F  L  L  L L+ N++  +P+ IF    NL  
Sbjct: 210 QGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTF 269

Query: 186 LDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIG 245
           L L +N +R L   +FA    L  L L HNQ   +    F  L +L++L L +N I+ + 
Sbjct: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329

Query: 246 QTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLN 305
             +      L +L L  N + A   P++FQ +  L+ L+L  N+LT + + I D+  +L 
Sbjct: 330 AGIFRDLEELVKLYLGSNNLTALH-PALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLF 388

Query: 306 DISLAGNIWECSRNICSLVNWLKSFKG-LRENTIICASPKELQG 348
           +++L GN W+C  ++  L NWL+ +   L      CA P  L+G
Sbjct: 389 NLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKG 432



 Score =  117 bits (292), Expect = 4e-26
 Identities = 85/289 (29%), Positives = 135/289 (46%), Gaps = 1/289 (0%)

Query: 24  LTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKG 83
           L +L+   + CP GC C  + V+C  ++L  +P  I      +     S   L+   F  
Sbjct: 12  LLLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGS 71

Query: 84  LNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYN 143
              LT +   +  +     +AF G+ RL++L ++ +       N F  +T+L  L L++N
Sbjct: 72  NPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFN 131

Query: 144 QLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAG 203
            L +L    F+ L  L SLHL+ N L+ +P R+FQ   +L+ L+L  N +  L   +F  
Sbjct: 132 MLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHP 191

Query: 204 MIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGN 263
           +  L+ L L +N  S L   +F +L SLQ L+L  N IS +   +      L+RL L  N
Sbjct: 192 LTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRN 251

Query: 264 EIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGN 312
            I      S+F  + NL  L+L  N L  +   +      L  +SL  N
Sbjct: 252 AITHLP-LSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHN 299



 Score = 37.4 bits (85), Expect = 0.038
 Identities = 31/146 (21%), Positives = 58/146 (39%), Gaps = 25/146 (17%)

Query: 168 SLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPR 227
           S  T+  R F    NL  +     ++     + F G+ RL++L +  + F  L+  +F  
Sbjct: 60  SFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSN 119

Query: 228 LVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDS 287
           L SL  L L +N +  + +                          +FQ +  L+ L+L  
Sbjct: 120 LTSLGKLTLNFNMLEALPE-------------------------GLFQHLAALESLHLQG 154

Query: 288 NKLTFIGQEILDSWISLNDISLAGNI 313
           N+L  + + +      L  ++LA N+
Sbjct: 155 NQLQALPRRLFQPLTHLKTLNLAQNL 180


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score =  123 bits (308), Expect = 5e-28
 Identities = 102/361 (28%), Positives = 154/361 (42%), Gaps = 35/361 (9%)

Query: 7   RLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKM--VYCESQKLQEIPSSISAGCL 64
           R L    + +++A  +L+       + CP  C C  +   V C  + L+E+P  IS    
Sbjct: 20  RALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTR 79

Query: 65  GLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYF 124
            L+L  N +Q +K N FK L  L  L L  NHI  I+  AFNG+  L  L L  NR++  
Sbjct: 80  LLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTI 139

Query: 125 LNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHL-RSNSLRTIPVRIFQDCRNL 183
            N  F  ++ L+ L L  N + S+ S  F  +  L  L L     L  I    F+   NL
Sbjct: 140 PNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNL 199

Query: 184 ELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISV 243
             L+L    +R +       +I+L EL L  N  S +    F  L+ LQ L++  ++I V
Sbjct: 200 RYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQV 257

Query: 244 IGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWIS 303
           I +                         + F  + +L  +NL  N LT +  ++      
Sbjct: 258 IER-------------------------NAFDNLQSLVEINLAHNNLTLLPHDLFTPLHH 292

Query: 304 LNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICA---SPKELQGVNVIDAVKNYSI 360
           L  I L  N W C+ +I  L  W+K       NT  CA   +P  L+G  + +  +NY  
Sbjct: 293 LERIHLHHNPWNCNCDILWLSWWIKDM--APSNTACCARCNTPPNLKGRYIGELDQNYFT 350

Query: 361 C 361
           C
Sbjct: 351 C 351


>gi|153251229 chondroadherin precursor [Homo sapiens]
          Length = 359

 Score =  122 bits (307), Expect = 7e-28
 Identities = 95/334 (28%), Positives = 152/334 (45%), Gaps = 9/334 (2%)

Query: 23  LLTMLSSAERGCPKGCRCEGKM--VYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQ 80
           LL  L  A   CP+ C C   +  V C+   LQ+IP  +S     L+L+ N+   L  N 
Sbjct: 12  LLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANS 70

Query: 81  FKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDL 140
           F+ +  L  L+L H  I  +   AF G+++L  L LS N I       F  +T L  L L
Sbjct: 71  FRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYL 130

Query: 141 SYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNV 200
            +N++  L       L  L  L L +N +R +    FQ  ++L  L L  N + SL    
Sbjct: 131 DHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGA 190

Query: 201 FAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSS-LQRLD 259
              +  L + H++ NQ S    A   +L  ++ L L  N +  I      ++   L+ L 
Sbjct: 191 LDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLW 250

Query: 260 LSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRN 319
           L    +E FS    F  V  L+ ++L++N+L  +       + SL  ++L  N W+C+  
Sbjct: 251 LDNTNLEKFSD-GAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNNPWKCTCQ 307

Query: 320 ICSLVNWLKSFKGLRENTIICASPKELQGVNVID 353
           +  L  WL++     + T  CASP + +G ++ D
Sbjct: 308 LRGLRRWLEAKASRPDAT--CASPAKFKGQHIRD 339


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score =  121 bits (303), Expect = 2e-27
 Identities = 93/307 (30%), Positives = 146/307 (47%), Gaps = 8/307 (2%)

Query: 13  AVALVIAPTVLLTMLSSAERGCPKGCRCEGKM-VYCESQKLQEIPSSISA----GCLGLS 67
           A+ L++     L +   AE  CP+ C C+    + C ++ L+ +P + S       L  S
Sbjct: 6   ALRLLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYS 65

Query: 68  LRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNN 127
           L  N +  +    F  L QL  L L +N I ++    F  + RL+EL L +N +      
Sbjct: 66  LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125

Query: 128 TFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLD 187
           T  P+  LR L  + N++  L    F GL  L+ L L  N+L  +P  +F    NL  L 
Sbjct: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185

Query: 188 LGYNRIRSLARNVFAGMIRLKELHLEHNQF--SKLNLALFPRLVSLQNLYLQWNKISVIG 245
           L  NRIR L +N FA + +L+ L+L  N+   S  + A F  L SL +L L  N +  +G
Sbjct: 186 LESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLG 245

Query: 246 QTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLN 305
             +      L  L L GN++   + P  F  +  L+ L L+ N+L+ +   +L+   SL 
Sbjct: 246 PRIFQHLPRLGLLSLRGNQLTHLA-PEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLE 304

Query: 306 DISLAGN 312
            + L+GN
Sbjct: 305 ALDLSGN 311



 Score =  114 bits (285), Expect = 2e-25
 Identities = 97/312 (31%), Positives = 141/312 (45%), Gaps = 33/312 (10%)

Query: 45  VYCESQKLQEIPSSISAGCLGLSLRY---NSLQKLKYNQFKGLNQLTWLYLDHNHISNID 101
           +Y  +  LQ +     A    L + Y   N + +L    F+GL  L  L LD N +  + 
Sbjct: 112 LYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALP 171

Query: 102 ENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSL--GSEQFRGLRKL 159
           +  F  +  L  L L SNRI +   N F  +  LR L+LS N+L      +  F  LR L
Sbjct: 172 DAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSL 231

Query: 160 LSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSK 219
            SL L +N+L+ +  RIFQ    L LL L  N++  LA   F G+  L+EL LE N+ S+
Sbjct: 232 SSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQ 291

Query: 220 LNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPN 279
           L  AL   L                         SL+ LDLSGNE+ A   P+ F  +  
Sbjct: 292 LPTALLEPL------------------------HSLEALDLSGNELSALH-PATFGHLGR 326

Query: 280 LQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSFKG---LREN 336
           L+ L+L +N L+ +  +I  +  +L  + L GN W C   +  L  W+  +     L   
Sbjct: 327 LRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTV 386

Query: 337 TIICASPKELQG 348
            + C  P  L+G
Sbjct: 387 FVQCRHPPALRG 398



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 73/247 (29%), Positives = 112/247 (45%), Gaps = 9/247 (3%)

Query: 1   MGFNVIRLLSGSAVALVIAPTVLLTM---LSSAERGCPKGCRCEGKMVYCESQKLQEIPS 57
           +G N+++ L+   +A +    +L      +S   RG  +G     K+   +   L  +P 
Sbjct: 114 LGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKL-RLDGNALGALPD 172

Query: 58  SISA---GCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENA--FNGIRRLK 112
           ++ A     L L L  N ++ L  N F  L +L +L L  N +     +A  F  +R L 
Sbjct: 173 AVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLS 232

Query: 113 ELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTI 172
            LILS+N + +     F+ +  L  L L  NQL  L  E F GL  L  L L  N L  +
Sbjct: 233 SLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQL 292

Query: 173 PVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQ 232
           P  + +   +LE LDL  N + +L    F  + RL+EL L +N  S L+  +F    +L 
Sbjct: 293 PTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALY 352

Query: 233 NLYLQWN 239
            L L  N
Sbjct: 353 RLDLDGN 359


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  119 bits (299), Expect = 6e-27
 Identities = 87/308 (28%), Positives = 137/308 (44%), Gaps = 26/308 (8%)

Query: 30  AERGCPKGCRCE-GKMVYCESQKLQEIPSSIS------------------------AGCL 64
           A  GCP  C C     V C   ++  +P+ +                         +  +
Sbjct: 27  AYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALI 86

Query: 65  GLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYF 124
            L +  N L ++    F+ L  L +L L +N +  +    F G+  L+ L+LSSN++   
Sbjct: 87  ALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQI 146

Query: 125 LNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLE 184
               F   +NL+ L L  N L  +    F  L  L  L+L  NSL  I  R+FQ   NL+
Sbjct: 147 QPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQ 206

Query: 185 LLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVI 244
           +L L  NR+  +    F G++ L+EL L+ NQ   L+  LF    +LQ LYL  N IS +
Sbjct: 207 VLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQL 266

Query: 245 GQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISL 304
             ++      L RL L GN ++  S   +F  +PNL+ L L  N ++ +   +  +   L
Sbjct: 267 PPSIFMQLPQLNRLTLFGNSLKELS-LGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 325

Query: 305 NDISLAGN 312
             + L+ N
Sbjct: 326 QVLILSRN 333



 Score =  117 bits (293), Expect = 3e-26
 Identities = 92/293 (31%), Positives = 139/293 (47%), Gaps = 3/293 (1%)

Query: 62  GCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRI 121
           G   L+L  NSL  +    F+ L  L  L L  N +++I    F+G+  L+EL L  N+I
Sbjct: 180 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 239

Query: 122 SYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCR 181
                  F    NL+ L LS N +  L    F  L +L  L L  NSL+ + + IF    
Sbjct: 240 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 299

Query: 182 NLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKI 241
           NL  L L  N I SL  NVF+ + +L+ L L  NQ S ++   F  L  L+ L L  N +
Sbjct: 300 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 359

Query: 242 SVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSW 301
             +   +    ++LQ + L  N +    G ++F  V  L  + L +N+L  +   I D  
Sbjct: 360 QDLDGNVFRMLANLQNISLQNNRLRQLPG-NIFANVNGLMAIQLQNNQLENLPLGIFDHL 418

Query: 302 ISLNDISLAGNIWECSRNICSLVNW-LKSFKGLRENTI-ICASPKELQGVNVI 352
             L ++ L  N W C  +I  L NW L +   L  +T+ +C SP  ++G ++I
Sbjct: 419 GKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLI 471



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 59/174 (33%), Positives = 92/174 (52%), Gaps = 3/174 (1%)

Query: 45  VYCESQKLQEIPSSISAGCLGLS---LRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNID 101
           +Y  +  + ++P SI      L+   L  NSL++L    F  +  L  L+L  NHIS++ 
Sbjct: 256 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 315

Query: 102 ENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLS 161
           +N F+ +R+L+ LILS N+IS+     F  +T LR L L  N L  L    FR L  L +
Sbjct: 316 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQN 375

Query: 162 LHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHN 215
           + L++N LR +P  IF +   L  + L  N++ +L   +F  + +L EL L  N
Sbjct: 376 ISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  119 bits (299), Expect = 6e-27
 Identities = 87/308 (28%), Positives = 137/308 (44%), Gaps = 26/308 (8%)

Query: 30  AERGCPKGCRCE-GKMVYCESQKLQEIPSSIS------------------------AGCL 64
           A  GCP  C C     V C   ++  +P+ +                         +  +
Sbjct: 21  AYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALI 80

Query: 65  GLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYF 124
            L +  N L ++    F+ L  L +L L +N +  +    F G+  L+ L+LSSN++   
Sbjct: 81  ALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQI 140

Query: 125 LNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLE 184
               F   +NL+ L L  N L  +    F  L  L  L+L  NSL  I  R+FQ   NL+
Sbjct: 141 QPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQ 200

Query: 185 LLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVI 244
           +L L  NR+  +    F G++ L+EL L+ NQ   L+  LF    +LQ LYL  N IS +
Sbjct: 201 VLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQL 260

Query: 245 GQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISL 304
             ++      L RL L GN ++  S   +F  +PNL+ L L  N ++ +   +  +   L
Sbjct: 261 PPSIFMQLPQLNRLTLFGNSLKELS-LGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 319

Query: 305 NDISLAGN 312
             + L+ N
Sbjct: 320 QVLILSRN 327



 Score =  117 bits (293), Expect = 3e-26
 Identities = 92/293 (31%), Positives = 139/293 (47%), Gaps = 3/293 (1%)

Query: 62  GCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRI 121
           G   L+L  NSL  +    F+ L  L  L L  N +++I    F+G+  L+EL L  N+I
Sbjct: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233

Query: 122 SYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCR 181
                  F    NL+ L LS N +  L    F  L +L  L L  NSL+ + + IF    
Sbjct: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293

Query: 182 NLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKI 241
           NL  L L  N I SL  NVF+ + +L+ L L  NQ S ++   F  L  L+ L L  N +
Sbjct: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 353

Query: 242 SVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSW 301
             +   +    ++LQ + L  N +    G ++F  V  L  + L +N+L  +   I D  
Sbjct: 354 QDLDGNVFRMLANLQNISLQNNRLRQLPG-NIFANVNGLMAIQLQNNQLENLPLGIFDHL 412

Query: 302 ISLNDISLAGNIWECSRNICSLVNW-LKSFKGLRENTI-ICASPKELQGVNVI 352
             L ++ L  N W C  +I  L NW L +   L  +T+ +C SP  ++G ++I
Sbjct: 413 GKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLI 465



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 59/174 (33%), Positives = 92/174 (52%), Gaps = 3/174 (1%)

Query: 45  VYCESQKLQEIPSSISAGCLGLS---LRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNID 101
           +Y  +  + ++P SI      L+   L  NSL++L    F  +  L  L+L  NHIS++ 
Sbjct: 250 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 309

Query: 102 ENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLS 161
           +N F+ +R+L+ LILS N+IS+     F  +T LR L L  N L  L    FR L  L +
Sbjct: 310 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQN 369

Query: 162 LHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHN 215
           + L++N LR +P  IF +   L  + L  N++ +L   +F  + +L EL L  N
Sbjct: 370 ISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423


>gi|38202222 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score =  116 bits (291), Expect = 5e-26
 Identities = 101/375 (26%), Positives = 168/375 (44%), Gaps = 16/375 (4%)

Query: 27  LSSAERGCPKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKY-NQFKGLN 85
           LS   + CP  CRC+   +YC  + L  IP+ I      L L+ N +      +  K L 
Sbjct: 24  LSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLL 83

Query: 86  QLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQL 145
           ++  +YL HN   ++DE   N  + +KEL L  N I     ++   +  L  L L  N +
Sbjct: 84  KVERIYLYHN---SLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSV 140

Query: 146 HSLGSEQ--FRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAG 203
            ++  E+  FR    L  L L  N L TIP  +    R +E L L  NRI +++     G
Sbjct: 141 SAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGL---PRTIEELRLDDNRISTISSPSLQG 197

Query: 204 MIRLKELHLEHNQFSKLNLA--LFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLS 261
           +  LK L L+ N  +   L   +F  LV+L  L L  N ++     +  T  +L++L L 
Sbjct: 198 LTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT--NLRKLYLQ 255

Query: 262 GNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNIC 321
            N I     P+ F  +  L RL++ +N L+ + Q I D   ++  + L  N W C   + 
Sbjct: 256 DNHINRVP-PNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMK 314

Query: 322 SLVNWLKSFK-GLRENTIICASPKELQGVNVIDAVKNYSICGKS-TTERFDLARALPKPT 379
            + +WL+S    +    ++C +P++++G+ + D       C  S       +  A+P   
Sbjct: 315 WVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTAIPNTV 374

Query: 380 FKPKLPRPKHESKPP 394
           +  +   P   +K P
Sbjct: 375 YPAQGQWPAPVTKQP 389


>gi|7019383 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score =  116 bits (291), Expect = 5e-26
 Identities = 101/375 (26%), Positives = 168/375 (44%), Gaps = 16/375 (4%)

Query: 27  LSSAERGCPKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKY-NQFKGLN 85
           LS   + CP  CRC+   +YC  + L  IP+ I      L L+ N +      +  K L 
Sbjct: 24  LSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLL 83

Query: 86  QLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQL 145
           ++  +YL HN   ++DE   N  + +KEL L  N I     ++   +  L  L L  N +
Sbjct: 84  KVERIYLYHN---SLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSV 140

Query: 146 HSLGSEQ--FRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAG 203
            ++  E+  FR    L  L L  N L TIP  +    R +E L L  NRI +++     G
Sbjct: 141 SAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGL---PRTIEELRLDDNRISTISSPSLQG 197

Query: 204 MIRLKELHLEHNQFSKLNLA--LFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLS 261
           +  LK L L+ N  +   L   +F  LV+L  L L  N ++     +  T  +L++L L 
Sbjct: 198 LTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT--NLRKLYLQ 255

Query: 262 GNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNIC 321
            N I     P+ F  +  L RL++ +N L+ + Q I D   ++  + L  N W C   + 
Sbjct: 256 DNHINRVP-PNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMK 314

Query: 322 SLVNWLKSFK-GLRENTIICASPKELQGVNVIDAVKNYSICGKS-TTERFDLARALPKPT 379
            + +WL+S    +    ++C +P++++G+ + D       C  S       +  A+P   
Sbjct: 315 WVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTAIPNTV 374

Query: 380 FKPKLPRPKHESKPP 394
           +  +   P   +K P
Sbjct: 375 YPAQGQWPAPVTKQP 389


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score =  116 bits (290), Expect = 6e-26
 Identities = 85/285 (29%), Positives = 132/285 (46%), Gaps = 7/285 (2%)

Query: 32  RGCPKGCRCE--GKM---VYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQ 86
           RGCP  C CE  G+M   V C    L E+PS++S     L L  N++ +L  N    L  
Sbjct: 32  RGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRF 91

Query: 87  LTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLH 146
           L  L L  N ++ I + AF G+  LK L+L +N++ +      + + +L++L L  N + 
Sbjct: 92  LEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHIS 151

Query: 147 SLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIR 206
            +    F GL  L  L L  N+L  IPV+ F+    L+ + L  N+I  +    F  +  
Sbjct: 152 YVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSS 211

Query: 207 LKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIE 266
           L  LHL +N+   L    F  L SL+ L L +N +     T   T S+L+ L    N I 
Sbjct: 212 LVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNNIR 270

Query: 267 AFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAG 311
           +      F   P+L  ++   N + F+G+        L  ++L G
Sbjct: 271 SIP-EKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNG 314



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 68/275 (24%), Positives = 122/275 (44%), Gaps = 55/275 (20%)

Query: 45  VYCESQKLQEIP----SSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNI 100
           ++ +   L EIP     S+SA    ++L  N +  +    F  L+ L  L+L +N I ++
Sbjct: 167 LWLDDNALTEIPVQAFRSLSA-LQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSL 225

Query: 101 DENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLL 160
            +  F+G+  L+ L L+ N +  F     R ++NL+ L    N + S+  + F G   L+
Sbjct: 226 GKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLI 284

Query: 161 SLHLRSNSLR-----------------------------------------------TIP 173
           ++H   N ++                                               ++P
Sbjct: 285 TIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLP 344

Query: 174 VRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQN 233
             +     NL++LDL YN +  L    F+   +L+++ L HN+  ++ +  F +L+SL++
Sbjct: 345 QTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRS 402

Query: 234 LYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAF 268
           L L WNKI++I      T  SL +LDLS N + +F
Sbjct: 403 LNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSF 437



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 31/88 (35%), Positives = 48/88 (54%), Gaps = 7/88 (7%)

Query: 52  LQEIPS-SISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRR 110
           L+++PS S+      + LR+N + ++K + F+ L  L  L L  N I+ I  NAF+ +  
Sbjct: 364 LEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPS 423

Query: 111 LKELILSSNRISYFLNNTFRPVTNLRNL 138
           L +L LSSN +S F      P+T L  L
Sbjct: 424 LIKLDLSSNLLSSF------PITGLHGL 445



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 35/102 (34%), Positives = 46/102 (45%), Gaps = 5/102 (4%)

Query: 66  LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
           L L YN L+ L    F    +L  + L HN I  I  + F  +  L+ L L+ N+I+   
Sbjct: 357 LDLSYNLLEDLP--SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIH 414

Query: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSN 167
            N F  + +L  LDLS N L S       GL  L  L L  N
Sbjct: 415 PNAFSTLPSLIKLDLSSNLLSSF---PITGLHGLTHLKLTGN 453


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score =  115 bits (289), Expect = 8e-26
 Identities = 80/279 (28%), Positives = 130/279 (46%), Gaps = 3/279 (1%)

Query: 34  CPKGCRCEG-KMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYL 92
           C   C C+G + V C  + L  +P  +SA    L +  N++ +L  + FK    L  L L
Sbjct: 29  CAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQL 88

Query: 93  DHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQ 152
             N +S I   A +G++ LK L L +N++    +   R ++ L++L L  N + S+  + 
Sbjct: 89  AGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDS 148

Query: 153 FRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHL 212
           F GL +L  L L  NSL  +PV    +   L+ L L  N+I S+    F  +  L  LHL
Sbjct: 149 FEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHL 208

Query: 213 EHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPS 272
            +N+   L+   F  L +L+ L L +N +    Q +     SL+ L    N I       
Sbjct: 209 HNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIK-ALPSLKELGFHSNSISVIP-DG 266

Query: 273 VFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAG 311
            F   P L+ ++L  N L+F+G     +   L+ + + G
Sbjct: 267 AFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRG 305



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 74/288 (25%), Positives = 113/288 (39%), Gaps = 67/288 (23%)

Query: 66  LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
           L L  N ++ L  + F GL+ L  L L++N++    + A   +  LKEL   SN IS   
Sbjct: 206 LHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ-AIKALPSLKELGFHSNSISVIP 264

Query: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSL---------------- 169
           +  F     LR + L  N L  +G+  F  L  L SL +R  S+                
Sbjct: 265 DGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESL 324

Query: 170 -------RTIPVRIFQDCRNLELLDLGYNRIR--------------SLARN--------V 200
                   +IP  + Q+ + L  LDL YN IR              SL RN         
Sbjct: 325 TLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGT 384

Query: 201 FAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDL 260
           F G+I L+ L L  N   +++   F  L  + NL + +N+++      +   + L +L L
Sbjct: 385 FQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELT---SFPTEGLNGLNQLKL 441

Query: 261 SGN-------------EIEAFSGPSVFQC-----VPNLQRLNLDSNKL 290
            GN              + + S P  +QC       +   LN + N L
Sbjct: 442 VGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYANLNTEDNSL 489


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score =  115 bits (288), Expect = 1e-25
 Identities = 82/283 (28%), Positives = 135/283 (47%), Gaps = 2/283 (0%)

Query: 66  LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
           L L  N +++L    FKGL  L  LYL +N +S +    FN +  ++ L L  NR++   
Sbjct: 113 LFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLG 172

Query: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
           + TF  +  LR LDLS N +  +    F+ L  L  L+L SN+L  +P   F+  ++L  
Sbjct: 173 SGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRR 232

Query: 186 LDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIG 245
           L L +N I ++    F G+  L+ L L++++   +    F  + +L++L L  N +  + 
Sbjct: 233 LSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLN 292

Query: 246 QTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLN 305
                   +L  L L  N I +    +      +L+ LNL  N LT +   +L    SL 
Sbjct: 293 SDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLI 352

Query: 306 DISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQG 348
            +    N WEC+  +  L +WL S   +  N I C +P  ++G
Sbjct: 353 HLQANSNPWECNCKLLGLRDWLAS-SAITLN-IYCQNPPSMRG 393



 Score =  110 bits (274), Expect = 5e-24
 Identities = 83/297 (27%), Positives = 142/297 (47%), Gaps = 26/297 (8%)

Query: 17  VIAPTVLLTMLSSAERGCPKGCR-CEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQK 75
           ++    LL +L     GC   C+ C G+ + C +  L  IP +     + L L  N++  
Sbjct: 15  LVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISY 74

Query: 76  LKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNL 135
           +  ++  GL+ L  LYLD+++I  +   AF  +R L  L         FLNN F     +
Sbjct: 75  INESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFL---------FLNNNF-----I 120

Query: 136 RNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRS 195
           + LD             F+GL  L +L+L+ N +  +P  +F D  +++ L+L  NR+  
Sbjct: 121 KRLDPGI----------FKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTV 170

Query: 196 LARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSL 255
           L    F GM+ L+ L L +N   +++ + F  L +L  LYL  N ++ +         SL
Sbjct: 171 LGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSL 230

Query: 256 QRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGN 312
           +RL LS N IEA   P  F+ + NL+ L L ++++  + ++      +L  + L+ N
Sbjct: 231 RRLSLSHNPIEAIQ-PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHN 286


>gi|12007646 nyctalopin precursor [Homo sapiens]
          Length = 481

 Score =  112 bits (281), Expect = 7e-25
 Identities = 111/432 (25%), Positives = 169/432 (39%), Gaps = 85/432 (19%)

Query: 9   LSGSAVALVIAPTVLLTMLSS-----AERGCPKGCRCE----GKMVYCESQKLQEIPSSI 59
           + G  + +++   V+L + S+       R CP  C C     G  V C+   L  +P+ +
Sbjct: 1   MKGRGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAEL 60

Query: 60  SAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSN 119
               + + L  N L+ L    F  L  L  L L HN++S I   AF G+ RL EL L+ N
Sbjct: 61  PCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHN 120

Query: 120 R-ISYFLNNTFRPVTNLRNLDLSYNQLHSL------------------------------ 148
             + Y    TF  ++ LR LDL+  +L S+                              
Sbjct: 121 GDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRG 180

Query: 149 -----------------GSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYN 191
                             S   +GLR+L SL L++N +R +    F DC  LE L L  N
Sbjct: 181 LANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDN 240

Query: 192 RIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWT 251
            +  L  + F G+ RL+ L+L  N   ++  A F  L  L+ LYL  N I          
Sbjct: 241 LLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSI---------- 290

Query: 252 WSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAG 311
                          AF     FQ +  L  L+L+ N+LT +          L  + L  
Sbjct: 291 ---------------AFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFR 335

Query: 312 NIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSICGKST-TERFD 370
           N W C   +  L +W++     R   + CASP  + G+++       S  G     E  +
Sbjct: 336 NPWCCDCRLEWLRDWMEG--SGRVTDVPCASPGSVAGLDLSQVTFGRSSDGLCVDPEELN 393

Query: 371 LARALPKPTFKP 382
           L  + P P+ +P
Sbjct: 394 LTTSSPGPSPEP 405


>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
           sapiens]
          Length = 757

 Score =  112 bits (279), Expect = 1e-24
 Identities = 92/307 (29%), Positives = 144/307 (46%), Gaps = 14/307 (4%)

Query: 35  PKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDH 94
           P  C C+G  + C+   L+ +PS +S+    +SL++N ++KL  + FK  + L  LYL +
Sbjct: 101 PVQCLCQGLELDCDETNLRAVPS-VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQN 159

Query: 95  NHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFR 154
           N I++I   AF G+  L +L LS NRI++     F  +  L  L +  N L  +    F 
Sbjct: 160 NKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFY 219

Query: 155 GLRKLLSLHLRSNSLRTIPVR-IFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLE 213
           GL  L+ L L +N L  +P + + Q    L  LDL  N I +L    F     L  L + 
Sbjct: 220 GLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMR 279

Query: 214 HNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSV 273
            N+ + LN   F  L  L  L L  NKI  +   +      L +L+LS N I+     + 
Sbjct: 280 KNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQA-NQ 338

Query: 274 FQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDI--------SLAGNIWECSRN---ICS 322
           F  +  L+ L+L+  +++ I Q +    ++L+ I          A ++  C  N   I S
Sbjct: 339 FDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISS 398

Query: 323 LVNWLKS 329
           L N L S
Sbjct: 399 LENLLAS 405


>gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]
          Length = 347

 Score =  112 bits (279), Expect = 1e-24
 Identities = 91/349 (26%), Positives = 157/349 (44%), Gaps = 41/349 (11%)

Query: 23  LLTMLSSAERGC---PKGCRC----EGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQK 75
           LL +L+++  G    PK C+      G  + C  Q   EIP  + A  + L++ + +L  
Sbjct: 25  LLLLLAASAWGVTLSPKDCQVFRSDHGSSISC--QPPAEIPGYLPADTVHLAVEFFNLTH 82

Query: 76  LKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNL 135
           L  N  +G ++L  L+L  N + ++       + +L+ L L+ N ++      F+    L
Sbjct: 83  LPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATL 142

Query: 136 RNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRS 195
             L L  NQL  L      GL+ L  L L  N LR +P  +  +   L  LDLG N++ +
Sbjct: 143 DTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLET 202

Query: 196 LARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSL 255
           L  ++  G ++L+ LHLE                         NK+ V+G+ +      L
Sbjct: 203 LPPDLLRGPLQLERLHLE------------------------GNKLQVLGKDLLLPQPDL 238

Query: 256 QRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDS-----WISLNDISLA 310
           + L L+GN++ A      FQ +  L  L+L +N L  + + +  S     W   +   ++
Sbjct: 239 RYLFLNGNKL-ARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDIS 297

Query: 311 GNIWECSRNICSLVNWLKSFKG--LRENTIICASPKELQGVNVIDAVKN 357
           GN W C +N+  L  WL++ K     +N   CA P+ ++G  ++   K+
Sbjct: 298 GNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKS 346


>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
           sapiens]
          Length = 660

 Score =  111 bits (278), Expect = 2e-24
 Identities = 97/376 (25%), Positives = 159/376 (42%), Gaps = 20/376 (5%)

Query: 34  CPKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYN-QFKGLNQLTWLYL 92
           CP  CRC+   VYC  + L  +P  I  G   L L  N +    +  +   +  +  +YL
Sbjct: 36  CPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYL 95

Query: 93  DHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQ 152
             N +   DE   N  + ++ L L  N I          +  L  L L  N + ++G E 
Sbjct: 96  YGNQL---DEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVED 152

Query: 153 --FRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKEL 210
             FR    L  L L  N L ++PV +  D + L + +   NRI  ++   F  +  L+ L
Sbjct: 153 GAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDE---NRIAVISDMAFQNLTSLERL 209

Query: 211 HLEHNQFSKLNLA--LFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAF 268
            ++ N  +   +A   F  L  L+   +  N +S     +  T   L RL L  N+I   
Sbjct: 210 IVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGT--HLIRLYLQDNQINHI 267

Query: 269 SGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLK 328
              + F  +  L+RL++ +N+L  + Q + D+  +L  ++   N W C  +I  +  WLK
Sbjct: 268 P-LTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLK 326

Query: 329 SF-KGLRENTIICASPKELQGVNVIDAVKNYSICGKST--TERFDLARALPKPTFKP--- 382
                L     +C  P++++G+ V +   N   C  +T     F  A +   PT +P   
Sbjct: 327 YIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTL 386

Query: 383 KLPRPKHESKPPLPPT 398
            +P P     PP P T
Sbjct: 387 SIPNPSRSYTPPTPTT 402


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score =  111 bits (277), Expect = 2e-24
 Identities = 99/356 (27%), Positives = 151/356 (42%), Gaps = 26/356 (7%)

Query: 11  GSAVALVIAPTVLL--TMLSSAERG---------CPKGCRC------EGKMVYCESQKLQ 53
           G A+AL++   V L    L  A+ G         CP  C C      +   V+C S+ L 
Sbjct: 45  GLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLT 104

Query: 54  EIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKE 113
            +P  +  G   L L  N+L  +    F+ L+ L +L L    + +++  A  G+  L  
Sbjct: 105 RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCH 164

Query: 114 LILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIP 173
           L L  N++      TF     L +L LS N+L  L    F GL  L  L+L  NSL  +P
Sbjct: 165 LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP 224

Query: 174 VRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQN 233
              F+   +L  L L  NR+  L   +F+G+  L+EL L  N    +   +F +L  LQ 
Sbjct: 225 DAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQK 284

Query: 234 LYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFI 293
           LYL  N I+ +         +L+ LDLS N +        F  +  L+ L L  N +  +
Sbjct: 285 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL-EDTFPGLLGLRVLRLSHNAIASL 343

Query: 294 GQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGV 349
                     L ++ L  N       I  L    +SF+GL +  ++     +LQ V
Sbjct: 344 RPRTFKDLHFLEELQLGHN------RIRQLAE--RSFEGLGQLEVLTLDHNQLQEV 391



 Score =  110 bits (274), Expect = 5e-24
 Identities = 73/247 (29%), Positives = 120/247 (48%), Gaps = 1/247 (0%)

Query: 66  LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
           L L  N L +L+   F+GL  L  L L  N ++ + + AF G+  L+EL+L+ NR++Y  
Sbjct: 189 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 248

Query: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
              F  +  LR LDLS N L ++ +  F  L +L  L+L  N +  +    F   + L  
Sbjct: 249 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 308

Query: 186 LDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIG 245
           LDL +NR+  L  + F G++ L+ L L HN  + L    F  L  L+ L L  N+I  + 
Sbjct: 309 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 368

Query: 246 QTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLN 305
           +        L+ L L  N+++       F  + N+  +NL  N L  + +++      L+
Sbjct: 369 ERSFEGLGQLEVLTLDHNQLQEVKA-GAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 427

Query: 306 DISLAGN 312
            + L G+
Sbjct: 428 SLHLEGS 434



 Score =  106 bits (264), Expect = 7e-23
 Identities = 80/257 (31%), Positives = 124/257 (48%), Gaps = 25/257 (9%)

Query: 66  LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
           L L  N+L+ +K N F  L +L  LYLD N I+ +   AF G++ L+ L LS NR++  L
Sbjct: 261 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL 320

Query: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
            +TF  +  LR L LS+N + SL    F+ L  L  L L  N +R +  R F+    LE+
Sbjct: 321 EDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEV 380

Query: 186 LDLGYNR------------------------IRSLARNVFAGMIRLKELHLEHNQFSKLN 221
           L L +N+                        +R+L   VF G+ +L  LHLE +   ++ 
Sbjct: 381 LTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIR 440

Query: 222 LALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQ 281
              F  L  L+ L+L+ N +  I +   W  + L  LDL+ N++       +FQ +  L+
Sbjct: 441 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLP-HRLFQGLGKLE 499

Query: 282 RLNLDSNKLTFIGQEIL 298
            L L  N+L  +  + L
Sbjct: 500 YLLLSRNRLAELPADAL 516



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 64/198 (32%), Positives = 96/198 (48%), Gaps = 4/198 (2%)

Query: 66  LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
           L+L +N LQ++K   F GL  +  + L  N + N+ E  F G+ +L  L L  + +    
Sbjct: 381 LTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIR 440

Query: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
            +TF  ++ LR L L  N L  +  +   GL +LL L L SN L  +P R+FQ    LE 
Sbjct: 441 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEY 500

Query: 186 LDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIG 245
           L L  NR+  L  +    + R   L + HN+   L  +L   L  L+ L L+ N +    
Sbjct: 501 LLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL---- 556

Query: 246 QTMSWTWSSLQRLDLSGN 263
           +T +     L+RL L GN
Sbjct: 557 RTFTPQPPGLERLWLEGN 574



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 36/111 (32%), Positives = 60/111 (54%)

Query: 61  AGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNR 120
           +G   L L+ N L  ++     GL +L  L L  N ++++    F G+ +L+ L+LS NR
Sbjct: 448 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNR 507

Query: 121 ISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRT 171
           ++    +   P+     LD+S+N+L +L +     L +L  L LR+NSLRT
Sbjct: 508 LAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRT 558


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score =  111 bits (277), Expect = 2e-24
 Identities = 99/356 (27%), Positives = 151/356 (42%), Gaps = 26/356 (7%)

Query: 11  GSAVALVIAPTVLL--TMLSSAERG---------CPKGCRC------EGKMVYCESQKLQ 53
           G A+AL++   V L    L  A+ G         CP  C C      +   V+C S+ L 
Sbjct: 7   GLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLT 66

Query: 54  EIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKE 113
            +P  +  G   L L  N+L  +    F+ L+ L +L L    + +++  A  G+  L  
Sbjct: 67  RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCH 126

Query: 114 LILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIP 173
           L L  N++      TF     L +L LS N+L  L    F GL  L  L+L  NSL  +P
Sbjct: 127 LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP 186

Query: 174 VRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQN 233
              F+   +L  L L  NR+  L   +F+G+  L+EL L  N    +   +F +L  LQ 
Sbjct: 187 DAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQK 246

Query: 234 LYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFI 293
           LYL  N I+ +         +L+ LDLS N +        F  +  L+ L L  N +  +
Sbjct: 247 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL-EDTFPGLLGLRVLRLSHNAIASL 305

Query: 294 GQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGV 349
                     L ++ L  N       I  L    +SF+GL +  ++     +LQ V
Sbjct: 306 RPRTFKDLHFLEELQLGHN------RIRQLAE--RSFEGLGQLEVLTLDHNQLQEV 353



 Score =  110 bits (274), Expect = 5e-24
 Identities = 73/247 (29%), Positives = 120/247 (48%), Gaps = 1/247 (0%)

Query: 66  LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
           L L  N L +L+   F+GL  L  L L  N ++ + + AF G+  L+EL+L+ NR++Y  
Sbjct: 151 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 210

Query: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
              F  +  LR LDLS N L ++ +  F  L +L  L+L  N +  +    F   + L  
Sbjct: 211 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 270

Query: 186 LDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIG 245
           LDL +NR+  L  + F G++ L+ L L HN  + L    F  L  L+ L L  N+I  + 
Sbjct: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 330

Query: 246 QTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLN 305
           +        L+ L L  N+++       F  + N+  +NL  N L  + +++      L+
Sbjct: 331 ERSFEGLGQLEVLTLDHNQLQEVKA-GAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 389

Query: 306 DISLAGN 312
            + L G+
Sbjct: 390 SLHLEGS 396



 Score =  106 bits (264), Expect = 7e-23
 Identities = 80/257 (31%), Positives = 124/257 (48%), Gaps = 25/257 (9%)

Query: 66  LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
           L L  N+L+ +K N F  L +L  LYLD N I+ +   AF G++ L+ L LS NR++  L
Sbjct: 223 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL 282

Query: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
            +TF  +  LR L LS+N + SL    F+ L  L  L L  N +R +  R F+    LE+
Sbjct: 283 EDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEV 342

Query: 186 LDLGYNR------------------------IRSLARNVFAGMIRLKELHLEHNQFSKLN 221
           L L +N+                        +R+L   VF G+ +L  LHLE +   ++ 
Sbjct: 343 LTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIR 402

Query: 222 LALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQ 281
              F  L  L+ L+L+ N +  I +   W  + L  LDL+ N++       +FQ +  L+
Sbjct: 403 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLP-HRLFQGLGKLE 461

Query: 282 RLNLDSNKLTFIGQEIL 298
            L L  N+L  +  + L
Sbjct: 462 YLLLSRNRLAELPADAL 478



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 64/198 (32%), Positives = 96/198 (48%), Gaps = 4/198 (2%)

Query: 66  LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
           L+L +N LQ++K   F GL  +  + L  N + N+ E  F G+ +L  L L  + +    
Sbjct: 343 LTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIR 402

Query: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
            +TF  ++ LR L L  N L  +  +   GL +LL L L SN L  +P R+FQ    LE 
Sbjct: 403 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEY 462

Query: 186 LDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIG 245
           L L  NR+  L  +    + R   L + HN+   L  +L   L  L+ L L+ N +    
Sbjct: 463 LLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL---- 518

Query: 246 QTMSWTWSSLQRLDLSGN 263
           +T +     L+RL L GN
Sbjct: 519 RTFTPQPPGLERLWLEGN 536



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 36/111 (32%), Positives = 60/111 (54%)

Query: 61  AGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNR 120
           +G   L L+ N L  ++     GL +L  L L  N ++++    F G+ +L+ L+LS NR
Sbjct: 410 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNR 469

Query: 121 ISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRT 171
           ++    +   P+     LD+S+N+L +L +     L +L  L LR+NSLRT
Sbjct: 470 LAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRT 520


>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  111 bits (277), Expect = 2e-24
 Identities = 94/384 (24%), Positives = 164/384 (42%), Gaps = 70/384 (18%)

Query: 34  CPKGCRC-------------EGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQ 80
           CP  C C             E   V C    L  +P ++ AG   L L+ NS+ ++  ++
Sbjct: 29  CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88

Query: 81  FKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDL 140
              L  LT L L  N  S+  +  F+ + +L  L L  N+++   +++F  + +L+ L L
Sbjct: 89  LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148

Query: 141 SYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRI------- 193
           ++NQL+ +    F GL  LL LHL SN LR I  R F+   NLE+L +G N++       
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208

Query: 194 -----------------RSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYL 236
                            R ++     G+  L+ L    NQ +++      ++  L+ L L
Sbjct: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268

Query: 237 QWNKISVIG---------------QTMSWTWS----------SLQRLDLSGNEIEAFSGP 271
             N +  +G                 M    S           L +LD++ N   +F  P
Sbjct: 269 NKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHP 328

Query: 272 SVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKS-- 329
             F  +P ++ L L++N L+ + Q+ ++S  +L ++ L GN   C      ++ W  +  
Sbjct: 329 RAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCD----CVIRWANATG 384

Query: 330 --FKGLRENTIICASPKELQGVNV 351
              + +   + +CA P +LQ + V
Sbjct: 385 TRVRFIEPQSTLCAEPPDLQRLPV 408


>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  111 bits (277), Expect = 2e-24
 Identities = 94/384 (24%), Positives = 164/384 (42%), Gaps = 70/384 (18%)

Query: 34  CPKGCRC-------------EGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQ 80
           CP  C C             E   V C    L  +P ++ AG   L L+ NS+ ++  ++
Sbjct: 29  CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88

Query: 81  FKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDL 140
              L  LT L L  N  S+  +  F+ + +L  L L  N+++   +++F  + +L+ L L
Sbjct: 89  LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148

Query: 141 SYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRI------- 193
           ++NQL+ +    F GL  LL LHL SN LR I  R F+   NLE+L +G N++       
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208

Query: 194 -----------------RSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYL 236
                            R ++     G+  L+ L    NQ +++      ++  L+ L L
Sbjct: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268

Query: 237 QWNKISVIG---------------QTMSWTWS----------SLQRLDLSGNEIEAFSGP 271
             N +  +G                 M    S           L +LD++ N   +F  P
Sbjct: 269 NKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHP 328

Query: 272 SVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKS-- 329
             F  +P ++ L L++N L+ + Q+ ++S  +L ++ L GN   C      ++ W  +  
Sbjct: 329 RAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCD----CVIRWANATG 384

Query: 330 --FKGLRENTIICASPKELQGVNV 351
              + +   + +CA P +LQ + V
Sbjct: 385 TRVRFIEPQSTLCAEPPDLQRLPV 408


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score =  110 bits (275), Expect = 4e-24
 Identities = 89/334 (26%), Positives = 145/334 (43%), Gaps = 35/334 (10%)

Query: 34  CPKGCRC--EGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLY 91
           CP  C C  +   V C  + L E+P+SI      L+L+ N +Q ++ + FK L  L  L 
Sbjct: 57  CPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQ 116

Query: 92  LDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSE 151
           L  N +  I+  AFNG+  L  L L  NR++      F  ++ LR L L  N + S+ S 
Sbjct: 117 LSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSY 176

Query: 152 QFRGLRKLLSLHL-RSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKEL 210
            F  +  L  L L     L  I    F+   NL  L+LG   ++ +       ++RL+EL
Sbjct: 177 AFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPN--LTALVRLEEL 234

Query: 211 HLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSG 270
            L  N+   +    F  L SL+ L+L   +++ I +                        
Sbjct: 235 ELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIER------------------------ 270

Query: 271 PSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSF 330
            + F  + +L+ LNL  N L  +  ++      L  + L  N W C+ ++  L  WLK  
Sbjct: 271 -NAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLK-- 327

Query: 331 KGLRENTIICA---SPKELQGVNVIDAVKNYSIC 361
           + +  NT  CA   +P  L+G  + +  +++  C
Sbjct: 328 ETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTC 361


>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
          Length = 716

 Score =  110 bits (274), Expect = 5e-24
 Identities = 101/394 (25%), Positives = 169/394 (42%), Gaps = 71/394 (18%)

Query: 24  LTMLSSAERGCPKGCRCE-------------GKMVYCESQKLQEIPSSISAGCLGLSLRY 70
           LT  S     CP+ C CE                V C   +L  IPS++S+    L L+ 
Sbjct: 22  LTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQS 81

Query: 71  NSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFR 130
           N++ K   ++ + L  LT L    N+ +NI E     + +L  L L  N+I+   +   +
Sbjct: 82  NNIAKT-VDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQ 140

Query: 131 PVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGY 190
            ++NL+ L +++NQ+ ++ +  F GL+ LL LHL SN L+ I  R F    NLE+L +G 
Sbjct: 141 DLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGE 200

Query: 191 NRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSW 250
           N +  +    F  +  L+ L L     + +       L SL++L    NK+  + Q    
Sbjct: 201 NPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQ 260

Query: 251 TWSSLQRLDLSGN------------------------------------------EIEAF 268
              +L+ LDL+ N                                          ++EA 
Sbjct: 261 KVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEAT 320

Query: 269 SGPSV-------FQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNIC 321
           + P +       F+ VP L+ L L++N L  I Q+ ++S  +L +IS+  N   C     
Sbjct: 321 NNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCD---- 376

Query: 322 SLVNWLKSFKG----LRENTIICASPKELQGVNV 351
            +++W+ S K     +   ++ CA P E +G  V
Sbjct: 377 CVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQV 410


>gi|62912470 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 1 [Homo sapiens]
          Length = 967

 Score =  110 bits (274), Expect = 5e-24
 Identities = 82/282 (29%), Positives = 124/282 (43%), Gaps = 6/282 (2%)

Query: 34  CPKGCRCEGKMVY----CESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTW 89
           CP  C C+   +     C    L  +P  +      L L  N+L +L+   F  L  L  
Sbjct: 35  CPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEE 94

Query: 90  LYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLG 149
           L L  NH+S+I   AF+G+  LK L+L +N++          + +L++L L  N +  + 
Sbjct: 95  LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 154

Query: 150 SEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKE 209
              F GL  L  L L  N+L  IPVR   +   L+ + L  NRI  +    F  +  L  
Sbjct: 155 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVV 214

Query: 210 LHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFS 269
           LHL +N+   L    F  L +L+ L L +NK+      +  T   LQ L    N I+A  
Sbjct: 215 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIR-TLGRLQELGFHNNNIKAIP 273

Query: 270 GPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAG 311
               F   P LQ ++   N + F+G+        L+ +SL G
Sbjct: 274 -EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 314



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 60/203 (29%), Positives = 96/203 (47%), Gaps = 10/203 (4%)

Query: 66  LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
           L L YN LQ+      + L +L  L   +N+I  I E AF G   L+ +    N I +  
Sbjct: 239 LDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG 297

Query: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLH---LRSNSLRTIPVRIFQDCRN 182
            + F+ +  L  L L+     ++  ++F  L+   SL    L    +R +P  + Q    
Sbjct: 298 RSAFQYLPKLHTLSLN----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPR 353

Query: 183 LELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKIS 242
           L +L+L +N+I  L         +L+E+ L+HN+  ++    F +L SLQ L L WN I 
Sbjct: 354 LRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIR 411

Query: 243 VIGQTMSWTWSSLQRLDLSGNEI 265
            I      T  SL +LDL+ N++
Sbjct: 412 SIHPEAFSTLHSLVKLDLTDNQL 434



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 65/255 (25%), Positives = 104/255 (40%), Gaps = 45/255 (17%)

Query: 51  KLQEIPSSISAGCLG----LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFN 106
           KLQE P +I    LG    L    N+++ +    F G   L  ++   N I  +  +AF 
Sbjct: 245 KLQEFPVAIRT--LGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQ 302

Query: 107 -----------------------GIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYN 143
                                  G   L+ L L+   I    +   + +  LR L+LS+N
Sbjct: 303 YLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHN 362

Query: 144 QLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAG 203
           Q+  L S      +KL  + L+ N +  I    F    +L+ LDL +N IRS+    F+ 
Sbjct: 363 QIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 420

Query: 204 MIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGN 263
           +  L +L L  NQ + L LA    L  L +L L+ N    +  + +++  S  +L +   
Sbjct: 421 LHSLVKLDLTDNQLTTLPLA---GLGGLMHLKLKGN----LALSQAFSKDSFPKLRI--- 470

Query: 264 EIEAFSGPSVFQCVP 278
                  P  +QC P
Sbjct: 471 ----LEVPYAYQCCP 481



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 32/104 (30%), Positives = 53/104 (50%), Gaps = 3/104 (2%)

Query: 210 LHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVI-GQTMSWTWSSLQRLDLSGNEIEAF 268
           L L  N  ++L   LF  L  L+ L L  N +S I GQ  S  +S L+ L L  N++   
Sbjct: 71  LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYS-LKILMLQNNQLGGI 129

Query: 269 SGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGN 312
              ++++ +P+LQ L LD+N ++ + +   +   SL  + L  N
Sbjct: 130 PAEALWE-LPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDN 172


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score =  109 bits (272), Expect = 8e-24
 Identities = 89/306 (29%), Positives = 138/306 (45%), Gaps = 5/306 (1%)

Query: 59  ISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSS 118
           +S   L L L  N + +L    FK L +LT L L+ N I  I+   F G+  L+ L L  
Sbjct: 186 LSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQR 244

Query: 119 NRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQ 178
           N IS   +  F  ++ +  L L YN L  + S    GL  L  LHL +NS+  I  + + 
Sbjct: 245 NNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWS 304

Query: 179 DCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQW 238
            C+ L  L L +N +  L     A +  L  L L HN  S +    F  L SL+ L L  
Sbjct: 305 FCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDH 364

Query: 239 NKISVIGQTMSWTWS---SLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQ 295
           N+IS   +  S  +S   SL +L L GN+I++ +    F  +  L+ LNL  N +  +  
Sbjct: 365 NEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVA-KRAFSGLEGLEHLNLGGNAIRSVQF 423

Query: 296 EILDSWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAV 355
           +      +L ++ ++ + + C   +  L  WL         T  CA P+ L+G ++    
Sbjct: 424 DAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVP 483

Query: 356 KNYSIC 361
               +C
Sbjct: 484 PESFVC 489



 Score =  108 bits (271), Expect = 1e-23
 Identities = 98/349 (28%), Positives = 153/349 (43%), Gaps = 34/349 (9%)

Query: 24  LTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKG 83
           +T  +     C   C C G  + C  + L  +P  + +    L+L YN L ++    F+ 
Sbjct: 31  VTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFED 90

Query: 84  L----------NQLT-------------WLYLDHNHISNIDENAFNGIRRLKELILSSNR 120
           L          N+LT              L+L HN I +++ +       L+ L LS N 
Sbjct: 91  LPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNN 150

Query: 121 ISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGL-RKLLSLHLRSNSLRTIPVRIFQD 179
           I+   N  F     ++ L+L+ N++ +L    F GL R LL+L L  N +  +PVR F+ 
Sbjct: 151 ITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKL 210

Query: 180 CRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWN 239
            R L  LDL  NRIR +    F G+  L+ L L+ N  SKL    F  L  +  L+L++N
Sbjct: 211 PR-LTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYN 269

Query: 240 KISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILD 299
            +  +     +  ++L +L LS N I          C   L  L L  N LT + +E L 
Sbjct: 270 SLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFC-QKLHELVLSFNNLTRLDEESLA 328

Query: 300 SWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQG 348
              SL+ + L+ N      +I  +     +FKGLR   ++     E+ G
Sbjct: 329 ELSSLSVLRLSHN------SISHIAE--GAFKGLRSLRVLDLDHNEISG 369


>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score =  109 bits (272), Expect = 8e-24
 Identities = 81/314 (25%), Positives = 142/314 (45%), Gaps = 34/314 (10%)

Query: 45  VYCESQKLQEIPSSISAGCLGLS---LRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNID 101
           VY E  KL E+P    +    L    + +N L  +    F GL+ L  L+L+ N +  I+
Sbjct: 121 VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN 180

Query: 102 ENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLS 161
              F+ +  L+ L++  N I    +  F+P+ NLR+L ++   L  +      GL  L S
Sbjct: 181 SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES 240

Query: 162 LHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLN 221
           +    N L  +P    Q   NL+ LDL  N I  + R  F+ M+ LKEL + +       
Sbjct: 241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINN------- 293

Query: 222 LALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQ 281
               P L+S+ +L +                  L++++ + N   ++  P+ F  +P L+
Sbjct: 294 ---MPELISIDSLAVD-------------NLPDLRKIEATNNPRLSYIHPNAFFRLPKLE 337

Query: 282 RLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLK----SFKGLRENT 337
            L L+SN L+ +    ++S  +L +IS+  N   C      ++ W+     + + +  ++
Sbjct: 338 SLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCD----CVIRWMNMNKTNIRFMEPDS 393

Query: 338 IICASPKELQGVNV 351
           + C  P E QG NV
Sbjct: 394 LFCVDPPEFQGQNV 407


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,951,244
Number of Sequences: 37866
Number of extensions: 1010983
Number of successful extensions: 7221
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 195
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 4507
Number of HSP's gapped (non-prelim): 1080
length of query: 581
length of database: 18,247,518
effective HSP length: 108
effective length of query: 473
effective length of database: 14,157,990
effective search space: 6696729270
effective search space used: 6696729270
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.