Search of human proteins with 15011981

Search of human proteins with 15011981

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
         (670 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...  1383   0.0  
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...  1324   0.0  
gi|23308553 spermatogenesis associated 13 [Homo sapiens]              657   0.0  
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]             604   e-173
gi|239753316 PREDICTED: similar to Rho guanine nucleotide exchan...   308   8e-84
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...   223   4e-58
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]          223   6e-58
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]          223   6e-58
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom...   135   9e-32
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom...   135   9e-32
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo...   135   9e-32
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom...   132   1e-30
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ...   132   1e-30
gi|71274148 pleckstrin homology domain containing, family G (wit...   120   5e-27
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...   117   3e-26
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...   114   4e-25
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]               108   2e-23
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo...   108   2e-23
gi|163644325 MCF.2 cell line derived transforming sequence-like ...   104   2e-22
gi|163644323 MCF.2 cell line derived transforming sequence-like ...   104   2e-22
gi|153791628 MCF.2 cell line derived transforming sequence isofo...   103   4e-22
gi|153791325 MCF.2 cell line derived transforming sequence isofo...   103   4e-22
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]    103   5e-22
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                   103   5e-22
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                   103   5e-22
gi|55749621 pleckstrin homology domain containing, family G, mem...   101   2e-21
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]          100   4e-21
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]           100   4e-21
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]   100   7e-21
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    99   1e-20

>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score = 1383 bits (3580), Expect = 0.0
 Identities = 670/670 (100%), Positives = 670/670 (100%)

Query: 1   MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPH 60
           MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPH
Sbjct: 1   MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPH 60

Query: 61  RSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSH 120
           RSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSH
Sbjct: 61  RSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSH 120

Query: 121 PLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGG 180
           PLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGG
Sbjct: 121 PLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGG 180

Query: 181 GGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGE 240
           GGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGE
Sbjct: 181 GGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGE 240

Query: 241 GWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYI 300
           GWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYI
Sbjct: 241 GWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYI 300

Query: 301 KHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSE 360
           KHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSE
Sbjct: 301 KHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSE 360

Query: 361 LGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFL 420
           LGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFL
Sbjct: 361 LGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFL 420

Query: 421 LTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQ 480
           LTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQ
Sbjct: 421 LTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQ 480

Query: 481 WQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDV 540
           WQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDV
Sbjct: 481 WQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDV 540

Query: 541 LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKA 600
           LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKA
Sbjct: 541 LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKA 600

Query: 601 FAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKGRRTAAPPPRLPGPYPADII 660
           FAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKGRRTAAPPPRLPGPYPADII
Sbjct: 601 FAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKGRRTAAPPPRLPGPYPADII 660

Query: 661 PFSEPQSQAS 670
           PFSEPQSQAS
Sbjct: 661 PFSEPQSQAS 670


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score = 1324 bits (3427), Expect = 0.0
 Identities = 650/676 (96%), Positives = 655/676 (96%), Gaps = 6/676 (0%)

Query: 1   MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPH 60
           MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPH
Sbjct: 1   MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPH 60

Query: 61  RSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSH 120
           RSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSH
Sbjct: 61  RSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSH 120

Query: 121 PLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGG 180
           PLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGG
Sbjct: 121 PLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGG 180

Query: 181 GGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGE 240
           GGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGE
Sbjct: 181 GGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGE 240

Query: 241 GWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYI 300
           GWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYI
Sbjct: 241 GWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYI 300

Query: 301 KHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSE 360
           KHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSE
Sbjct: 301 KHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSE 360

Query: 361 LGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFL 420
           LGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFL
Sbjct: 361 LGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFL 420

Query: 421 LTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQ 480
           LTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQ
Sbjct: 421 LTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQ 480

Query: 481 WQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDV 540
           WQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDV
Sbjct: 481 WQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDV 540

Query: 541 LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKA 600
           LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKA
Sbjct: 541 LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKA 600

Query: 601 FAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPK--GR---RTAAPPPRLPGPY 655
           FAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPK  GR    T    P LP   
Sbjct: 601 FAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKAVGRPCYLTRQKHPALPSNR 660

Query: 656 P-ADIIPFSEPQSQAS 670
           P   ++  +EP+ + S
Sbjct: 661 PQQQVLVLAEPRRKPS 676


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score =  657 bits (1694), Expect = 0.0
 Identities = 337/560 (60%), Positives = 413/560 (73%), Gaps = 13/560 (2%)

Query: 118 RSHPLSQSAPTGLNHMGWPEHTPGTAMP-DGALDTAVCADEVGSEEDL-YDDLHSSSHHY 175
           R    SQS P GL+ +G       + +  DG  + +   D+ GSEED  Y+DL  +S  Y
Sbjct: 71  RPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSYEDLCQASPRY 130

Query: 176 SHPGGGGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGR 235
             PGG  EQLAINELISDG+VVCAEALWDHVTMDDQELGFKAGDVI+V++A+N++WWWGR
Sbjct: 131 LQPGG--EQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGR 188

Query: 236 VADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQ---SSKDQMRTNVINEI 292
             D E WFPASFVRLRVNQ+E +++ +        E+          +K QMRTNVI EI
Sbjct: 189 SEDKEAWFPASFVRLRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREI 248

Query: 293 LSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFN 352
           + TER YIKHLRDICEGY+RQCRK   MF+  QL TIFGNIEDIY+ Q+ F+K LE+++N
Sbjct: 249 MDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYN 308

Query: 353 RERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMI 412
           +E PHLSE+G+CFL++Q  F IYSEYCNNHP AC+EL+ L K  KY +FFEACRLLQ+MI
Sbjct: 309 KEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMI 368

Query: 413 DISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRL 472
           DI++DGFLLTPVQKICKYPLQLAELLKYT  +H D+ +++AA  AMKNVA LINERKR+L
Sbjct: 369 DIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKL 428

Query: 473 ENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCK 532
           E+IDKIA+WQ SI  WEG D+L RSSELI+SGELT++T+ Q KSQQR FFLFDHQL+ CK
Sbjct: 429 ESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITK-QGKSQQRTFFLFDHQLVSCK 487

Query: 533 KDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPE 592
           KDLLRRD+LYYKGRLDMD +E+VDL DG+D+D ++S+KNAF+L    T + +L C +K E
Sbjct: 488 KDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQE 547

Query: 593 QKQRWLKAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKGRRTAAPPPRLP 652
            K RWL+A A ER +VQ D+E G  I+E Q+K AMLNA K    GK KG       P   
Sbjct: 548 DKARWLQACADERRRVQEDKEMGMEISENQKKLAMLNAQKAG-HGKSKGYNRCPVAPPHQ 606

Query: 653 GPYPAD----IIPFSEPQSQ 668
           G +P       +P S PQ Q
Sbjct: 607 GLHPIHQRHITMPTSVPQQQ 626


>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
          Length = 516

 Score =  604 bits (1558), Expect = e-173
 Identities = 295/492 (59%), Positives = 376/492 (76%), Gaps = 18/492 (3%)

Query: 190 LISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVR 249
           LI+  S+V AEA+WDHVTM ++EL FKAGDVI+V+DA+N++WWWG++ D EGWFPASFVR
Sbjct: 4   LITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVR 63

Query: 250 LRVNQDEPADDDAPLAGNSGAEDGGAEAQS----------SKDQMRTNVINEILSTERDY 299
           L VNQ++  ++     G S  ++G  +  S          ++DQMR NVINEI+STER Y
Sbjct: 64  LWVNQEDEVEE-----GPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHY 118

Query: 300 IKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLS 359
           IKHL+DICEGY++QCRKR DMFS+EQL+ IFGNIEDIYR Q  FV+ LE+++N + PHLS
Sbjct: 119 IKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLS 178

Query: 360 ELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGF 419
           E+G CFLEHQ  F IYSEYCNNH +AC+ELS+L K S+Y +FFEACRLLQ+MIDI++DGF
Sbjct: 179 EIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGF 238

Query: 420 LLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIA 479
           LLTPVQKICKYPLQLAELLKYT   H D++ V AAL  M+NV Q INERKRRLENIDKIA
Sbjct: 239 LLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIA 298

Query: 480 QWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRD 539
           QWQ+S+ DWEGED+L RSSELIY+GE+  + QP  ++QQR+FFLFDHQ++ CKKDL+RRD
Sbjct: 299 QWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRD 358

Query: 540 VLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLK 599
           +LYYKGR+DMD  EVVD+EDG+D D +VS+KNAF+LH   T + HL   +K E+K RWL+
Sbjct: 359 ILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLR 418

Query: 600 AFAREREQVQLDQETGFSITELQRKQAML---NASKQQVTGKPKGRRTAAPPPRLPGPYP 656
           AF  ER+ VQ D++ GF I+E Q++QA +      KQ+     +    + PPP+ P  + 
Sbjct: 419 AFREERKMVQEDEKIGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPLNHG 478

Query: 657 ADIIPFSEPQSQ 668
             ++P    QSQ
Sbjct: 479 QYLVPDGIAQSQ 490


>gi|239753316 PREDICTED: similar to Rho guanine nucleotide exchange
           factor 4 [Homo sapiens]
          Length = 368

 Score =  308 bits (790), Expect = 8e-84
 Identities = 143/143 (100%), Positives = 143/143 (100%)

Query: 1   MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPH 60
           MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPH
Sbjct: 1   MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPH 60

Query: 61  RSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSH 120
           RSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSH
Sbjct: 61  RSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSH 120

Query: 121 PLSQSAPTGLNHMGWPEHTPGTA 143
           PLSQSAPTGLNHMGWPEHTPGTA
Sbjct: 121 PLSQSAPTGLNHMGWPEHTPGTA 143


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score =  223 bits (568), Expect = 4e-58
 Identities = 150/435 (34%), Positives = 228/435 (52%), Gaps = 45/435 (10%)

Query: 256 EPADDDA-------PLAGNSGAEDGG----AEAQSSKDQMRTN--VINEILSTERDYIKH 302
           EP  D A       P A  + A   G    A A+ S+ Q+R    V+NEIL TERDY+  
Sbjct: 8   EPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGT 67

Query: 303 LRDICEGYVRQCRKR-ADM----FSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPH 357
           LR +   ++ + R+  AD      +EE ++ +F NIEDI    K F+ ALE   + E   
Sbjct: 68  LRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQS 127

Query: 358 LSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLL--QKMIDIS 415
             ELG  FL+ +  F +Y EYC+NH  A   L  L K+     F  +C LL  +K  DI 
Sbjct: 128 QHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIP 187

Query: 416 LDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENI 475
           L+G+LL+P+Q+ICKYPL L EL K T  +H D   V++AL AMK V   INE KR++E +
Sbjct: 188 LEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKL 247

Query: 476 DKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKK-- 533
           + + Q QS IE WEG +L    ++L+  G L +++      Q+R FFLFD+ L+YCK+  
Sbjct: 248 EALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKIS--AGNIQERAFFLFDNLLVYCKRKS 305

Query: 534 ------------DLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLH---VSIKNAFRLHRG 578
                         +   +  ++GR++ + +EV ++EDG   D H    ++ N +++H  
Sbjct: 306 RVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDG-TADYHSNGYTVTNGWKIHNT 364

Query: 579 ATGDSHLLCTRKPEQKQRWLKAFAREREQ-----VQLDQETGFSITELQRKQAMLNASKQ 633
           A     +   +  E+KQ+WL A  REREQ     + ++++    I E   K   +  +K+
Sbjct: 365 AKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNKK 424

Query: 634 QVTGKPKGRRTAAPP 648
               K + R+ +  P
Sbjct: 425 VNLIKDRRRKLSTVP 439


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score =  223 bits (567), Expect = 6e-58
 Identities = 136/405 (33%), Positives = 222/405 (54%), Gaps = 40/405 (9%)

Query: 273 GGAEAQSSKD-----QMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADM-----FS 322
           G + A+S+KD     ++R  V++E+  TERDY+  L  +   ++ +  + A        +
Sbjct: 7   GDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVT 66

Query: 323 EEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNH 382
           EE ++ +F NIEDI    K F+K +E+  + E     E+G CFL  +  F+IY EYC+NH
Sbjct: 67  EETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNH 126

Query: 383 PNACVELSRLTKLSKYVYFFEACRLL--QKMIDISLDGFLLTPVQKICKYPLQLAELLKY 440
             A   L  L K+     F   C LL  +K  D+ L+G+L+TP+Q+ICKYPL L ELLK 
Sbjct: 127 EKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKR 186

Query: 441 THPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSEL 500
           T  +H D+  V  AL AMK V   INE KR++E ++ + +WQS IE WEG ++    +E+
Sbjct: 187 TPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEM 246

Query: 501 IYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLR---------RDVLYYKGRLDMDG 551
           +  G L +++      Q+R+FFLFD+ L+YCK+   R              ++GR++ + 
Sbjct: 247 LMCGVLLKIS--SGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEV 304

Query: 552 LEVVDLEDGKDRDLHVS---IKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFARERE-- 606
           +EV +++DG   D H S   + N +++H  A     +   + PE+K  W +A  +ERE  
Sbjct: 305 MEVENVDDG-TADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERR 363

Query: 607 ---QVQLDQETGFSITE--------LQRKQAMLNASKQQVTGKPK 640
              ++ ++Q+T   I+E        + R+  ++   K+++T  PK
Sbjct: 364 KGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPK 408


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score =  223 bits (567), Expect = 6e-58
 Identities = 136/405 (33%), Positives = 222/405 (54%), Gaps = 40/405 (9%)

Query: 273 GGAEAQSSKD-----QMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADM-----FS 322
           G + A+S+KD     ++R  V++E+  TERDY+  L  +   ++ +  + A        +
Sbjct: 7   GDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVT 66

Query: 323 EEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNH 382
           EE ++ +F NIEDI    K F+K +E+  + E     E+G CFL  +  F+IY EYC+NH
Sbjct: 67  EETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNH 126

Query: 383 PNACVELSRLTKLSKYVYFFEACRLL--QKMIDISLDGFLLTPVQKICKYPLQLAELLKY 440
             A   L  L K+     F   C LL  +K  D+ L+G+L+TP+Q+ICKYPL L ELLK 
Sbjct: 127 EKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKR 186

Query: 441 THPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSEL 500
           T  +H D+  V  AL AMK V   INE KR++E ++ + +WQS IE WEG ++    +E+
Sbjct: 187 TPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEM 246

Query: 501 IYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLR---------RDVLYYKGRLDMDG 551
           +  G L +++      Q+R+FFLFD+ L+YCK+   R              ++GR++ + 
Sbjct: 247 LMCGVLLKIS--SGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEV 304

Query: 552 LEVVDLEDGKDRDLHVS---IKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFARERE-- 606
           +EV +++DG   D H S   + N +++H  A     +   + PE+K  W +A  +ERE  
Sbjct: 305 MEVENVDDG-TADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERR 363

Query: 607 ---QVQLDQETGFSITE--------LQRKQAMLNASKQQVTGKPK 640
              ++ ++Q+T   I+E        + R+  ++   K+++T  PK
Sbjct: 364 KGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPK 408


>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
           sapiens]
          Length = 753

 Score =  135 bits (341), Expect = 9e-32
 Identities = 111/465 (23%), Positives = 207/465 (44%), Gaps = 21/465 (4%)

Query: 152 AVCADEVGSEEDLYDDLHSSS-HHYSHPGGGGEQLAINELISDGSVVCAEALWDHVTMDD 210
           +VCA         +D L S S H  +     G+  +++   +  + +   A ++    ++
Sbjct: 91  SVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNE 150

Query: 211 QELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGA 270
            EL F  GDVI V       WW G +    GWFP+++VR     ++P    +P +G   +
Sbjct: 151 DELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTLKS 207

Query: 271 EDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIF 330
              G +  +        V+  IL TE +Y K L+ +   Y+R   + ++  S   +  + 
Sbjct: 208 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISYLM 266

Query: 331 GNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACVEL 389
           GN+E+I   Q+  V++LE+           +G CFL      + +Y  YC NHP+A   +
Sbjct: 267 GNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA---V 322

Query: 390 SRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFK 449
           + LT+ S+ +  F   +       + L   L  P  ++ KYP  L EL ++    H D +
Sbjct: 323 NVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQ 382

Query: 450 DVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRV 509
           D++ ++ A KN++    E ++R E   ++     +I +WEG+D+    +    S  L + 
Sbjct: 383 DIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQC 440

Query: 510 TQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSI 569
              + K+ +R   LF + L+       R     Y+G+L   G+ +  LED ++       
Sbjct: 441 AGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH------ 492

Query: 570 KNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614
           +NAF +  G+  +  L+     +  Q W++   ++ +   +   T
Sbjct: 493 RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPT 536


>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
           sapiens]
          Length = 803

 Score =  135 bits (341), Expect = 9e-32
 Identities = 111/465 (23%), Positives = 207/465 (44%), Gaps = 21/465 (4%)

Query: 152 AVCADEVGSEEDLYDDLHSSS-HHYSHPGGGGEQLAINELISDGSVVCAEALWDHVTMDD 210
           +VCA         +D L S S H  +     G+  +++   +  + +   A ++    ++
Sbjct: 141 SVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNE 200

Query: 211 QELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGA 270
            EL F  GDVI V       WW G +    GWFP+++VR     ++P    +P +G   +
Sbjct: 201 DELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTLKS 257

Query: 271 EDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIF 330
              G +  +        V+  IL TE +Y K L+ +   Y+R   + ++  S   +  + 
Sbjct: 258 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISYLM 316

Query: 331 GNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACVEL 389
           GN+E+I   Q+  V++LE+           +G CFL      + +Y  YC NHP+A   +
Sbjct: 317 GNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA---V 372

Query: 390 SRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFK 449
           + LT+ S+ +  F   +       + L   L  P  ++ KYP  L EL ++    H D +
Sbjct: 373 NVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQ 432

Query: 450 DVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRV 509
           D++ ++ A KN++    E ++R E   ++     +I +WEG+D+    +    S  L + 
Sbjct: 433 DIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQC 490

Query: 510 TQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSI 569
              + K+ +R   LF + L+       R     Y+G+L   G+ +  LED ++       
Sbjct: 491 AGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH------ 542

Query: 570 KNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614
           +NAF +  G+  +  L+     +  Q W++   ++ +   +   T
Sbjct: 543 RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPT 586


>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
           sapiens]
          Length = 782

 Score =  135 bits (341), Expect = 9e-32
 Identities = 111/465 (23%), Positives = 207/465 (44%), Gaps = 21/465 (4%)

Query: 152 AVCADEVGSEEDLYDDLHSSS-HHYSHPGGGGEQLAINELISDGSVVCAEALWDHVTMDD 210
           +VCA         +D L S S H  +     G+  +++   +  + +   A ++    ++
Sbjct: 120 SVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNE 179

Query: 211 QELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGA 270
            EL F  GDVI V       WW G +    GWFP+++VR     ++P    +P +G   +
Sbjct: 180 DELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTLKS 236

Query: 271 EDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIF 330
              G +  +        V+  IL TE +Y K L+ +   Y+R   + ++  S   +  + 
Sbjct: 237 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISYLM 295

Query: 331 GNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACVEL 389
           GN+E+I   Q+  V++LE+           +G CFL      + +Y  YC NHP+A   +
Sbjct: 296 GNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA---V 351

Query: 390 SRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFK 449
           + LT+ S+ +  F   +       + L   L  P  ++ KYP  L EL ++    H D +
Sbjct: 352 NVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQ 411

Query: 450 DVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRV 509
           D++ ++ A KN++    E ++R E   ++     +I +WEG+D+    +    S  L + 
Sbjct: 412 DIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQC 469

Query: 510 TQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSI 569
              + K+ +R   LF + L+       R     Y+G+L   G+ +  LED ++       
Sbjct: 470 AGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH------ 521

Query: 570 KNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614
           +NAF +  G+  +  L+     +  Q W++   ++ +   +   T
Sbjct: 522 RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPT 565


>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
           sapiens]
          Length = 646

 Score =  132 bits (332), Expect = 1e-30
 Identities = 101/407 (24%), Positives = 185/407 (45%), Gaps = 20/407 (4%)

Query: 209 DDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNS 268
           ++ EL F  GDVI V       WW G +    GWFP+++VR     ++P    +P +G  
Sbjct: 21  NEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTL 77

Query: 269 GAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRT 328
            +   G +  +        V+  IL TE +Y K L+ +   Y+R   + ++  S   +  
Sbjct: 78  KSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISY 136

Query: 329 IFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACV 387
           + GN+E+I   Q+  V++LE+           +G CFL      + +Y  YC NHP+A  
Sbjct: 137 LMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA-- 193

Query: 388 ELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRD 447
            ++ LT+ S+ +  F   +       + L   L  P  ++ KYP  L EL ++    H D
Sbjct: 194 -VNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTD 252

Query: 448 FKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELT 507
            +D++ ++ A KN++    E ++R E   ++     +I +WEG+D+    +    S  L 
Sbjct: 253 RQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLI 310

Query: 508 RVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHV 567
           +    + K+ +R   LF + L+       R     Y+G+L   G+ +  LED ++     
Sbjct: 311 QCAGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH---- 364

Query: 568 SIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614
             +NAF +  G+  +  L+     +  Q W++   ++ +   +   T
Sbjct: 365 --RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPT 408


>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
           sapiens]
          Length = 646

 Score =  132 bits (332), Expect = 1e-30
 Identities = 101/407 (24%), Positives = 185/407 (45%), Gaps = 20/407 (4%)

Query: 209 DDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNS 268
           ++ EL F  GDVI V       WW G +    GWFP+++VR     ++P    +P +G  
Sbjct: 21  NEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTL 77

Query: 269 GAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRT 328
            +   G +  +        V+  IL TE +Y K L+ +   Y+R   + ++  S   +  
Sbjct: 78  KSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISY 136

Query: 329 IFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACV 387
           + GN+E+I   Q+  V++LE+           +G CFL      + +Y  YC NHP+A  
Sbjct: 137 LMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA-- 193

Query: 388 ELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRD 447
            ++ LT+ S+ +  F   +       + L   L  P  ++ KYP  L EL ++    H D
Sbjct: 194 -VNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTD 252

Query: 448 FKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELT 507
            +D++ ++ A KN++    E ++R E   ++     +I +WEG+D+    +    S  L 
Sbjct: 253 RQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLI 310

Query: 508 RVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHV 567
           +    + K+ +R   LF + L+       R     Y+G+L   G+ +  LED ++     
Sbjct: 311 QCAGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH---- 364

Query: 568 SIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614
             +NAF +  G+  +  L+     +  Q W++   ++ +   +   T
Sbjct: 365 --RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPT 408


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score =  120 bits (300), Expect = 5e-27
 Identities = 84/271 (30%), Positives = 133/271 (49%), Gaps = 14/271 (5%)

Query: 288 VINEILSTERDYIKHLRDICEGYVRQCRKRADM-FSEEQLRTIFGNIEDIYRCQKAFVKA 346
           V+ EIL TER Y++ L+ I E Y+   R +  +    E+   +FGNI+DIY      ++ 
Sbjct: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQD 176

Query: 347 LEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACR 406
           LE   N E   ++ +  CF+    +F IY++YC N+P +   L+   +      FF   +
Sbjct: 177 LE---NCENDPVA-IAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQ 232

Query: 407 LLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLIN 466
              K   + L  +LL PVQ+I KY L L E+  +       +  V  A+  M+ VA  IN
Sbjct: 233 ETLKH-SLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHIN 291

Query: 467 ERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDH 526
           + KR+ E+  ++ + QS + +W+G D L    EL+  G      + Q    +R  FLFD 
Sbjct: 292 DMKRKHEHAVRLQEIQSLLTNWKGPD-LTSYGELVLEGTF----RIQRAKNERTLFLFDK 346

Query: 527 QLIYCKKDLLRRDVLYYKGRLDMDGLEVVDL 557
            L+  KK   R D   YK  +    L +V++
Sbjct: 347 LLLITKK---RDDTFTYKAHILCGNLMLVEV 374


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score =  117 bits (294), Expect = 3e-26
 Identities = 118/393 (30%), Positives = 174/393 (44%), Gaps = 37/393 (9%)

Query: 279 SSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADM-FSEEQLRTIFGNIEDIY 337
           S++      V  EI+ TER Y++ LR I E Y+        +  S EQ+ T+F NIEDIY
Sbjct: 97  SARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIY 156

Query: 338 RCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSK 397
                 ++ LE   +        +  CF++   DF IY+ YC N+P++   L  L+ LS 
Sbjct: 157 EFSSELLEDLENSSSA-----GGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELS-LSP 210

Query: 398 YVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKY--THPQHRDFKDVEAAL 455
               +   R  Q    + L  FLL PVQ+I KY L L EL K+    P     + VE A+
Sbjct: 211 PAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAI 270

Query: 456 HAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELT--RVTQPQ 513
            +M  VA  IN+ KR+ E+  ++ + Q  +  W G +L     EL+  G         P+
Sbjct: 271 VSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSA-FGELVLEGAFRGGGGGGPR 329

Query: 514 AKSQQRMFFLFDHQLIYCKKDLLRRDVLY-YKGRLDMDGLEVVDLEDGKDRDLHVSIKN- 571
            +  +R+ FLF   L+  K    RR + Y YKG +    L V   E  +D  L   + + 
Sbjct: 330 LRGGERLLFLFSRMLLVAK----RRGLEYTYKGHIFCCNLSV--SESPRD-PLGFKVSDL 382

Query: 572 AFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQETGFSITELQRKQAMLNAS 631
               HR      HLL  +  E+K+ W+    R      L  E   +    + KQ +L  S
Sbjct: 383 TIPKHR------HLLQAKNQEEKRLWIHCLQR------LFFENHPASIPAKAKQVLLENS 430

Query: 632 KQQVTGKPKGRRTAAP-PPRLPGPYPADIIPFS 663
              +   PK +    P  P L  P P D   F+
Sbjct: 431 ---LHCAPKSKPVLEPLTPPLGSPRPRDARSFT 460


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
           sapiens]
          Length = 1054

 Score =  114 bits (284), Expect = 4e-25
 Identities = 85/319 (26%), Positives = 145/319 (45%), Gaps = 21/319 (6%)

Query: 288 VINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKAL 347
           ++ EIL+TER Y+K L ++   + R    + D      +  +F NI+ IY   + F++ +
Sbjct: 539 IVKEILATERTYLKDL-EVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREV 597

Query: 348 EQRF----NRERPHLS----ELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYV 399
           EQR        + H       +G   L +    + ++ Y   H     EL + TK  K +
Sbjct: 598 EQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKL 657

Query: 400 YFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMK 459
                   LQK+  + L+ FLL P+Q++  Y L L  L  +  P H D+ D   AL A+ 
Sbjct: 658 EAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAIT 717

Query: 460 NVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQR 519
            V   +     RLEN+ K+ + Q  +     E+L+    E I  G L ++T+     QQR
Sbjct: 718 EVTTTLQHILIRLENLQKLTELQRDLVGI--ENLIAPGREFIREGCLHKLTKKGL--QQR 773

Query: 520 MFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGA 579
           MFFLF   L+Y  K +        +G L + G+ V      ++ D   S+ + F ++  A
Sbjct: 774 MFFLFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLV------EESDNEWSVPHCFTIY--A 825

Query: 580 TGDSHLLCTRKPEQKQRWL 598
              + ++      +K++W+
Sbjct: 826 AQKTIVVAASTRLEKEKWM 844


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score =  108 bits (270), Expect = 2e-23
 Identities = 80/343 (23%), Positives = 163/343 (47%), Gaps = 32/343 (9%)

Query: 202  LWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPAD-- 259
            ++D+   +D EL F  G +I V++  + +WW G V    G FP+++V+L  + D      
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWC 1222

Query: 260  DDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRAD 319
             D  L           +  +  ++ R   I+E++ TE +Y+  L+ + E + +   + ++
Sbjct: 1223 SDLHL----------LDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLME-SE 1271

Query: 320  MFSEEQLRTIFGNIEDIYRCQKAFVKAL--EQRFNRERPHLSELGACFLEHQADFQIYSE 377
            + +E+++  IF N +++  C    +KAL   ++ + E+  +  +G          Q Y  
Sbjct: 1272 LLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIR 1331

Query: 378  YCNNHPNACVELSRLT-KLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAE 436
            +C+   N    + + T +   +  F +   +  +   + L  F+L P+Q++ +YPL +  
Sbjct: 1332 FCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKN 1391

Query: 437  LLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEG--EDLL 494
            +L+ T   H D   ++ AL   + +   +NE  R  EN D++ +W  +    EG  E L+
Sbjct: 1392 ILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRL-EWIQAHVQCEGLSEQLV 1450

Query: 495  VRS-------SELIYSGELTRVTQPQAKSQQRMF-FLFDHQLI 529
              S        + ++SG+L +     AKS + ++ FLF+  L+
Sbjct: 1451 FNSVTNCLGPRKFLHSGKLYK-----AKSNKELYGFLFNDFLL 1488



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 10/98 (10%)

Query: 199  AEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPA 258
            A+AL+      D  L F   DVI V++  +  WW+G V   +GWFP S+V+L        
Sbjct: 918  AQALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKL-------- 968

Query: 259  DDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTE 296
                P+  ++  + G +E+ +S  ++ +     ++S E
Sbjct: 969  -ISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGE 1005



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 24/80 (30%), Positives = 43/80 (53%), Gaps = 4/80 (5%)

Query: 201  ALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADD 260
            A++ + + +  +L F+ GDVI ++   + +WW G V D  G FP+++VRL+   D     
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYVRLK---DSEGSG 1064

Query: 261  DAPLAGNSGAEDGGAEAQSS 280
             A   G+ G +   A+  +S
Sbjct: 1065 TAGKTGSLGKKPEIAQVIAS 1084


>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
           sapiens]
          Length = 776

 Score =  108 bits (269), Expect = 2e-23
 Identities = 102/418 (24%), Positives = 185/418 (44%), Gaps = 29/418 (6%)

Query: 189 ELISDGS-VVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASF 247
           E+  +GS  +  +A ++    ++ EL    GD+I V       WW G +    GWFP+++
Sbjct: 154 EMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNY 213

Query: 248 VRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDIC 307
           VR   + + P    A           G E         T V+  IL TE++Y K L+ + 
Sbjct: 214 VREIKSSERPLSPKAV---------KGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLL 264

Query: 308 EGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLE 367
             Y+R  +   ++ S  ++ ++ GN E++   Q+   +ALE+  ++   +  ++G C L 
Sbjct: 265 VTYLRPLQSNNNL-STVEVTSLLGNFEEVCTFQQTLCQALEE-CSKFPENQHKVGGCLLS 322

Query: 368 HQADFQ-IYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQK 426
               F+ +Y  YC NHP+A   ++ LT+ S  +  F   +       + L   L  P  +
Sbjct: 323 LMPHFKSMYLAYCANHPSA---VNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMR 379

Query: 427 ICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKN-VAQLINERKRRLENIDKIAQWQSSI 485
           + KY   L EL ++    H D +D+  A+ A K  + Q  + RKR+   +  +++    I
Sbjct: 380 LEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSE---PI 436

Query: 486 EDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKG 545
           + WEGED+    + +  S  + +    + K ++R   LF + LI       R     Y+G
Sbjct: 437 QAWEGEDIKNLGNVIFMSQVMVQYGACEEK-EERYLMLFSNVLIMLSAS-PRMSGFIYQG 494

Query: 546 RLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAR 603
           ++ + G  V  L++ +  D    I        G T +  ++     +  Q WL+   R
Sbjct: 495 KIPIAGTVVTRLDEIEGNDCTFEI-------TGNTVERIVVHCNNNQDFQEWLEQLNR 545


>gi|163644325 MCF.2 cell line derived transforming sequence-like
           isoform a [Homo sapiens]
          Length = 1182

 Score =  104 bits (260), Expect = 2e-22
 Identities = 94/341 (27%), Positives = 163/341 (47%), Gaps = 44/341 (12%)

Query: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRK--RADMFS---EEQLRTIF 330
           E + S   +R +V++E+L TER Y++ L  + EGY  +      A + S     +   +F
Sbjct: 650 EEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLF 709

Query: 331 GNIEDIYRCQ-KAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVEL 389
           GN+E+IY    + F++ LE     + P L  +G CFLE   DFQIY +YC N P +    
Sbjct: 710 GNMEEIYHFHNRIFLRELENY--TDCPEL--VGRCFLERMEDFQIYEKYCQNKPRS---- 761

Query: 390 SRLTKLSKYVYFFEACRLLQKMID--ISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRD 447
             L +      FF+ C   Q+ +D  +SLD +LL PVQ+I KY L L E+LKY+      
Sbjct: 762 ESLWRQCSDCPFFQEC---QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSR-NCEG 817

Query: 448 FKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGEL- 506
            +D++ AL ++  + + +N+      ++  I  +  ++ D     LL++ S  +++    
Sbjct: 818 AEDLQEALSSILGILKAVNDSM----HLIAITGYDGNLGDL--GKLLMQGSFSVWTDHKR 871

Query: 507 --TRVTQ-PQAKSQQRMFFLFDHQLIYCKK------DLLRRDVLYYKGRLDMDGLEVVDL 557
             T+V +  + K  QR  FL +  +++CKK         +     YK  L+M  + + + 
Sbjct: 872 GHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITEN 931

Query: 558 EDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWL 598
             G  +         F +   A  + +++    PE K  W+
Sbjct: 932 VKGDAK--------KFEIWYNAREEVYIVQAPTPEIKAAWV 964



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 43/180 (23%), Positives = 70/180 (38%), Gaps = 20/180 (11%)

Query: 108  TSPESLNLPRRSHPLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDD 167
            TSP   N  R    L +     L+  G+    P T  P+     +  +  + + ED  D 
Sbjct: 1001 TSPSRGN-SRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPED--DG 1057

Query: 168  LHSSSHHYSHPGGGGEQ--LAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMD 225
              SS+    +     E   L   +L+     V A    DH       L  ++GDV+E++ 
Sbjct: 1058 GWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVA----DHEKGGPDALRVRSGDVVELVQ 1113

Query: 226  ATNREWWWGR--VADGEGWFPASFVRLR---------VNQDEPADDDAPLAGNSGAEDGG 274
              +   W+ R      EGW PAS + +R         ++  E +   A L+ +S   +GG
Sbjct: 1114 EGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGG 1173


>gi|163644323 MCF.2 cell line derived transforming sequence-like
           isoform b [Homo sapiens]
          Length = 1129

 Score =  104 bits (260), Expect = 2e-22
 Identities = 94/341 (27%), Positives = 163/341 (47%), Gaps = 44/341 (12%)

Query: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRK--RADMFS---EEQLRTIF 330
           E + S   +R +V++E+L TER Y++ L  + EGY  +      A + S     +   +F
Sbjct: 597 EEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLF 656

Query: 331 GNIEDIYRCQ-KAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVEL 389
           GN+E+IY    + F++ LE     + P L  +G CFLE   DFQIY +YC N P +    
Sbjct: 657 GNMEEIYHFHNRIFLRELENY--TDCPEL--VGRCFLERMEDFQIYEKYCQNKPRS---- 708

Query: 390 SRLTKLSKYVYFFEACRLLQKMID--ISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRD 447
             L +      FF+ C   Q+ +D  +SLD +LL PVQ+I KY L L E+LKY+      
Sbjct: 709 ESLWRQCSDCPFFQEC---QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSR-NCEG 764

Query: 448 FKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGEL- 506
            +D++ AL ++  + + +N+      ++  I  +  ++ D     LL++ S  +++    
Sbjct: 765 AEDLQEALSSILGILKAVNDSM----HLIAITGYDGNLGDL--GKLLMQGSFSVWTDHKR 818

Query: 507 --TRVTQ-PQAKSQQRMFFLFDHQLIYCKK------DLLRRDVLYYKGRLDMDGLEVVDL 557
             T+V +  + K  QR  FL +  +++CKK         +     YK  L+M  + + + 
Sbjct: 819 GHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITEN 878

Query: 558 EDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWL 598
             G  +         F +   A  + +++    PE K  W+
Sbjct: 879 VKGDAK--------KFEIWYNAREEVYIVQAPTPEIKAAWV 911



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 43/180 (23%), Positives = 70/180 (38%), Gaps = 20/180 (11%)

Query: 108  TSPESLNLPRRSHPLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDD 167
            TSP   N  R    L +     L+  G+    P T  P+     +  +  + + ED  D 
Sbjct: 948  TSPSRGN-SRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPED--DG 1004

Query: 168  LHSSSHHYSHPGGGGEQ--LAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMD 225
              SS+    +     E   L   +L+     V A    DH       L  ++GDV+E++ 
Sbjct: 1005 GWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVA----DHEKGGPDALRVRSGDVVELVQ 1060

Query: 226  ATNREWWWGR--VADGEGWFPASFVRLR---------VNQDEPADDDAPLAGNSGAEDGG 274
              +   W+ R      EGW PAS + +R         ++  E +   A L+ +S   +GG
Sbjct: 1061 EGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGG 1120


>gi|153791628 MCF.2 cell line derived transforming sequence isoform
           a [Homo sapiens]
          Length = 985

 Score =  103 bits (258), Expect = 4e-22
 Identities = 103/404 (25%), Positives = 179/404 (44%), Gaps = 80/404 (19%)

Query: 265 AGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEE 324
           +G S + D G    +S D ++ +V+NE++ TER Y++ L  +  GY      RA+M + E
Sbjct: 540 SGPSSSLDNG----NSLDVLKNHVLNELIQTERVYVRELYTVLLGY------RAEMDNPE 589

Query: 325 Q-------LRT----IFGNIEDIYRCQK-AFVKALEQRFNRERPHLSELGACFLEHQADF 372
                   LR     +FGN+ +IY      F+ +LE   +        +G CFLE + DF
Sbjct: 590 MFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPE----RVGPCFLERKDDF 645

Query: 373 QIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPL 432
           Q+Y++YC N P +    +   K S+  +F E  R L+    + LD +LL PVQ+I KY L
Sbjct: 646 QMYAKYCQNKPRS---ETIWRKYSECAFFQECQRKLKHR--LRLDSYLLKPVQRITKYQL 700

Query: 433 QLAELLKYTHPQHRDFKDVEA------ALHAMKNVAQLINERKRRLE------NIDKIAQ 480
            L ELLKY+       KD E       AL AM ++ + +N+   ++       N++++ +
Sbjct: 701 LLKELLKYS-------KDCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGK 753

Query: 481 --WQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLL-- 536
              Q     W G             G        + K  QR  FL++  +++CK+ +   
Sbjct: 754 MIMQGGFSVWIGHK----------KGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESG 803

Query: 537 ----RRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPE 592
               R     +K    MD + + +   G +R         F +  G   + +++     +
Sbjct: 804 EGSDRYPSYSFKHCWKMDEVGITEYVKGDNR--------KFEIWYGEKEEVYIVQASNVD 855

Query: 593 QKQRWLKAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVT 636
            K  WLK    E   + L Q+   ++ + +++  +    K Q++
Sbjct: 856 VKMTWLK----EIRNILLKQQELLTVKKRKQQDQLTERDKFQIS 895


>gi|153791325 MCF.2 cell line derived transforming sequence isoform
           b [Homo sapiens]
          Length = 925

 Score =  103 bits (258), Expect = 4e-22
 Identities = 103/404 (25%), Positives = 179/404 (44%), Gaps = 80/404 (19%)

Query: 265 AGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEE 324
           +G S + D G    +S D ++ +V+NE++ TER Y++ L  +  GY      RA+M + E
Sbjct: 480 SGPSSSLDNG----NSLDVLKNHVLNELIQTERVYVRELYTVLLGY------RAEMDNPE 529

Query: 325 Q-------LRT----IFGNIEDIYRCQK-AFVKALEQRFNRERPHLSELGACFLEHQADF 372
                   LR     +FGN+ +IY      F+ +LE   +        +G CFLE + DF
Sbjct: 530 MFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPE----RVGPCFLERKDDF 585

Query: 373 QIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPL 432
           Q+Y++YC N P +    +   K S+  +F E  R L+    + LD +LL PVQ+I KY L
Sbjct: 586 QMYAKYCQNKPRS---ETIWRKYSECAFFQECQRKLKHR--LRLDSYLLKPVQRITKYQL 640

Query: 433 QLAELLKYTHPQHRDFKDVEA------ALHAMKNVAQLINERKRRLE------NIDKIAQ 480
            L ELLKY+       KD E       AL AM ++ + +N+   ++       N++++ +
Sbjct: 641 LLKELLKYS-------KDCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGK 693

Query: 481 --WQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLL-- 536
              Q     W G             G        + K  QR  FL++  +++CK+ +   
Sbjct: 694 MIMQGGFSVWIGHK----------KGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESG 743

Query: 537 ----RRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPE 592
               R     +K    MD + + +   G +R         F +  G   + +++     +
Sbjct: 744 EGSDRYPSYSFKHCWKMDEVGITEYVKGDNR--------KFEIWYGEKEEVYIVQASNVD 795

Query: 593 QKQRWLKAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVT 636
            K  WLK    E   + L Q+   ++ + +++  +    K Q++
Sbjct: 796 VKMTWLK----EIRNILLKQQELLTVKKRKQQDQLTERDKFQIS 835


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score =  103 bits (257), Expect = 5e-22
 Identities = 89/349 (25%), Positives = 157/349 (44%), Gaps = 14/349 (4%)

Query: 254 QDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQ 313
           ++E A+ D        +E      + ++   R   + EI  TE  Y   L  I + +++ 
Sbjct: 164 ENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKP 223

Query: 314 CRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ 373
            ++       + +  IF NIED+ R    F+K +++      P  + L   F++++  F 
Sbjct: 224 LQR---FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGT--PGAANLYQVFIKYKERFL 278

Query: 374 IYSEYCNNHPNACVELSRLTKLSKYVYF-FEACRLLQKMIDISLDGFLLTPVQKICKYPL 432
           +Y  YC+   +A   L R+    + V    E C         +L   L+ P+Q++ KY L
Sbjct: 279 VYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHL 338

Query: 433 QLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGED 492
            L EL+K+T  +  + +++  AL AM+++AQ +NE KR  E + +I  +Q SIE+   + 
Sbjct: 339 LLQELVKHTQ-EAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENL--DQ 395

Query: 493 LLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGL 552
            L         GEL   +  +     R  FL D  L+ CK+   R D    K  +++   
Sbjct: 396 SLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKR---RGDSYDLKDFVNLHSF 452

Query: 553 EVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAF 601
           +V D   G DRD +    + F L        + L  +  E K++W++ F
Sbjct: 453 QVRDDSSG-DRD-NKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQF 499



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 19/51 (37%), Positives = 31/51 (60%), Gaps = 1/51 (1%)

Query: 199 AEALWDHVTMDDQELGFKAGDVIEVMDATNREWWW-GRVADGEGWFPASFV 248
           A+A +D    D  EL  K GD+I++++   ++ WW G +    GWFPA++V
Sbjct: 787 AKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYV 837



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 32/143 (22%), Positives = 59/143 (41%), Gaps = 22/143 (15%)

Query: 213 LGFKAGDVIEVMDA-TNREWWWGRVADGE--GWFPASFVRLRVNQDEPADDDAPLAGNSG 269
           L    GD++E+  A   + WW GR       GWFP + V+  V+   P D    L     
Sbjct: 617 LRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH-GPPQDLSVHLWYAGP 675

Query: 270 AEDGGAEAQSSKDQMRTNVINEILSTERDY---------IKHLRDI-CEGYVRQCRKRA- 318
            E  GAE+  +     T ++ + +    ++         +KH++ +  EG  R   K+A 
Sbjct: 676 MERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAF 735

Query: 319 -------DMFSEEQLRTIFGNIE 334
                  + + +  L+  F +++
Sbjct: 736 RGLTELVEFYQQNSLKDCFKSLD 758


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score =  103 bits (257), Expect = 5e-22
 Identities = 82/342 (23%), Positives = 157/342 (45%), Gaps = 28/342 (8%)

Query: 201  ALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADD 260
            A++D+   ++ EL F  G +I VM+  + +WW G +    G FP+++V++  + D     
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQW 1166

Query: 261  DAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADM 320
             A L           +     ++ R   I+E++ TE  Y+  L+ + E + ++  + +  
Sbjct: 1167 CADLQT--------LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAE-SGF 1217

Query: 321  FSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNR--ERPHLSELGACFLEHQADFQIYSEY 378
             +E ++  IF N +++       +KAL  R     E+  +  +G       +  Q Y  +
Sbjct: 1218 LTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRF 1277

Query: 379  CNNHPNACVELSRLT-KLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAEL 437
            C+   N    L + T + + +  F +      +   + L  FLL P+Q+I +YPL +  +
Sbjct: 1278 CSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSI 1337

Query: 438  LKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEG--EDLLV 495
            L+ T   H D   ++ AL   + +   +NE  R  EN D++ +W  +    EG  E L+ 
Sbjct: 1338 LENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRL-EWIQAHVQCEGLAEQLIF 1396

Query: 496  RS-------SELIYSGELTRVTQPQAKSQQRMF-FLFDHQLI 529
             S        +L++SG+L +      KS + +  FLF+  L+
Sbjct: 1397 NSLTNCLGPRKLLHSGKLYK-----TKSNKELHGFLFNDFLL 1433



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 23/63 (36%), Positives = 33/63 (52%), Gaps = 5/63 (7%)

Query: 199 AEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRL----RVNQ 254
           A+AL       D  L F   D+I V++     WW+G V  G GWFP S+V++     V +
Sbjct: 876 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 934

Query: 255 DEP 257
           +EP
Sbjct: 935 EEP 937



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 17/50 (34%), Positives = 27/50 (54%), Gaps = 2/50 (4%)

Query: 201 ALWDHVTMDDQELGFKAGDVIEVMDATNRE--WWWGRVADGEGWFPASFV 248
           AL+     +  E+ F +GD+I+V + T  E  W +G      GWFP ++V
Sbjct: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYV 786



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 22/80 (27%), Positives = 41/80 (51%), Gaps = 4/80 (5%)

Query: 201  ALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADD 260
            AL+ + +++  +L F  G+ I V      EWW G + D  G FP+++V+    +D+ +  
Sbjct: 961  ALYPYSSVEPGDLTFTEGEEILVTQKDG-EWWTGSIGDRSGIFPSNYVK---PKDQESFG 1016

Query: 261  DAPLAGNSGAEDGGAEAQSS 280
             A  +G S  +   A+  S+
Sbjct: 1017 SASKSGASNKKPEIAQVTSA 1036


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score =  103 bits (257), Expect = 5e-22
 Identities = 82/342 (23%), Positives = 157/342 (45%), Gaps = 28/342 (8%)

Query: 201  ALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADD 260
            A++D+   ++ EL F  G +I VM+  + +WW G +    G FP+++V++  + D     
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQW 1193

Query: 261  DAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADM 320
             A L           +     ++ R   I+E++ TE  Y+  L+ + E + ++  + +  
Sbjct: 1194 CADLQT--------LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAE-SGF 1244

Query: 321  FSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNR--ERPHLSELGACFLEHQADFQIYSEY 378
             +E ++  IF N +++       +KAL  R     E+  +  +G       +  Q Y  +
Sbjct: 1245 LTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRF 1304

Query: 379  CNNHPNACVELSRLT-KLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAEL 437
            C+   N    L + T + + +  F +      +   + L  FLL P+Q+I +YPL +  +
Sbjct: 1305 CSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSI 1364

Query: 438  LKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEG--EDLLV 495
            L+ T   H D   ++ AL   + +   +NE  R  EN D++ +W  +    EG  E L+ 
Sbjct: 1365 LENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRL-EWIQAHVQCEGLAEQLIF 1423

Query: 496  RS-------SELIYSGELTRVTQPQAKSQQRMF-FLFDHQLI 529
             S        +L++SG+L +      KS + +  FLF+  L+
Sbjct: 1424 NSLTNCLGPRKLLHSGKLYK-----TKSNKELHGFLFNDFLL 1460



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 23/63 (36%), Positives = 33/63 (52%), Gaps = 5/63 (7%)

Query: 199 AEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRL----RVNQ 254
           A+AL       D  L F   D+I V++     WW+G V  G GWFP S+V++     V +
Sbjct: 903 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 961

Query: 255 DEP 257
           +EP
Sbjct: 962 EEP 964



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 17/50 (34%), Positives = 27/50 (54%), Gaps = 2/50 (4%)

Query: 201 ALWDHVTMDDQELGFKAGDVIEVMDATNRE--WWWGRVADGEGWFPASFV 248
           AL+     +  E+ F +GD+I+V + T  E  W +G      GWFP ++V
Sbjct: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYV 813



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 22/80 (27%), Positives = 41/80 (51%), Gaps = 4/80 (5%)

Query: 201  ALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADD 260
            AL+ + +++  +L F  G+ I V      EWW G + D  G FP+++V+    +D+ +  
Sbjct: 988  ALYPYSSVEPGDLTFTEGEEILVTQKDG-EWWTGSIGDRSGIFPSNYVK---PKDQESFG 1043

Query: 261  DAPLAGNSGAEDGGAEAQSS 280
             A  +G S  +   A+  S+
Sbjct: 1044 SASKSGASNKKPEIAQVTSA 1063


>gi|55749621 pleckstrin homology domain containing, family G, member
           3 [Homo sapiens]
          Length = 1163

 Score =  101 bits (252), Expect = 2e-21
 Identities = 89/314 (28%), Positives = 148/314 (47%), Gaps = 36/314 (11%)

Query: 354 ERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFF-EACRLLQKMI 412
           ER ++ +L +  +    +F IY++YCNN+PN+   L+   +  +   FF +   LLQ   
Sbjct: 105 ERMYVQDLRS--IVESQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQH-- 160

Query: 413 DISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRL 472
            + L  +LL PVQ+I KY L L E+ K+   +   F+ VE A+  M  VA  IN+ KRR 
Sbjct: 161 SLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRH 220

Query: 473 ENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCK 532
           E+  ++ + QS + +W+G D L    EL+  G   RV + +    +R FFLFD  L+  K
Sbjct: 221 EHAVRLQEIQSLLINWKGPD-LTTYGELVLEGTF-RVHRVR---NERTFFLFDKTLLITK 275

Query: 533 KDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPE 592
           K   R D   YKG +    L ++  E  +D  L  ++      H   +   + +  +  E
Sbjct: 276 K---RGDHFVYKGNIPCSSLMLI--ESTRD-SLCFTV-----THYKHSKQQYSIQAKTVE 324

Query: 593 QKQRW---LKAFAREREQVQLDQETGFSITEL------------QRKQAMLNASKQQVTG 637
           +K+ W   +K    E     + Q+   +I E+            +R +   ++  +  T 
Sbjct: 325 EKRNWTHHIKRLILENHHATIPQKAKEAILEMDSYYPNRYRCSPERLKKAWSSQDEVSTN 384

Query: 638 KPKGRRTAAPPPRL 651
             +GRR + P   L
Sbjct: 385 VRQGRRQSEPTKHL 398


>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
          Length = 2986

 Score =  100 bits (249), Expect = 4e-21
 Identities = 102/389 (26%), Positives = 184/389 (47%), Gaps = 60/389 (15%)

Query: 285  RTNVINEILSTERDYIKHLRDICEGYVRQCRKRA---DMFSEEQLRTIFGNIEDIYRCQK 341
            R  V+NE++ TE+DY+K L  + EG++++  ++    DM  ++++  +FGNI  IY   K
Sbjct: 1930 RMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKI--VFGNIHQIYDWHK 1987

Query: 342  AFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYF 401
             F  A  ++  +E+  L++L   F++H+    IY  YC N P      S         YF
Sbjct: 1988 DFFLAELEKCIQEQDRLAQL---FIKHERKLHIYVWYCQNKPR-----SEYIVAEYDAYF 2039

Query: 402  FEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNV 461
             E  + + + + +S   FL+ P+Q+I KY L L + L+Y+     +  D+E A+  M   
Sbjct: 2040 EEVKQEINQRLTLS--DFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELM--- 2094

Query: 462  AQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMF 521
              L+ +R   + N+ ++  ++ ++   +G+ L     +  Y  EL      Q+++++R  
Sbjct: 2095 -CLVPKRCNDMMNLGRLQGFEGTLTA-QGKLL---QQDTFYVIELD--AGMQSRTKERRV 2147

Query: 522  FLFDHQLIYCKKDLLRRDVL----YYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHR 577
            FLF+  +I+   +LLR+  L     +K  + M+ L    LE+  D D        F L  
Sbjct: 2148 FLFEQIVIF--SELLRKGSLTPGYMFKRSIKMNYLV---LEENVDND-----PCKFALMN 2197

Query: 578  GATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTG 637
              T +  +L     + +Q W+    ++  QV            L+ ++  LNA +  +  
Sbjct: 2198 RETSERVVLQAANADIQQAWV----QDINQV------------LETQRDFLNALQSPIEY 2241

Query: 638  KPKGRRTA---APPPRLP--GPYPADIIP 661
            + K R TA   + P RLP   P P   +P
Sbjct: 2242 QRKERSTAVMRSQPARLPQASPRPYSSVP 2270



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 89/325 (27%), Positives = 141/325 (43%), Gaps = 49/325 (15%)

Query: 288  VINEILSTERDYIKHLRDICEGYVRQCRKRAD-----MFSEEQLRTIFGNIEDIYRCQK- 341
            ++ E+L TE+ Y++ L +  E Y+ +     +     + ++E +  IFGNI++IY     
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHI--IFGNIQEIYDFHNN 1342

Query: 342  AFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYF 401
             F+K LE+    + P   ++G CF+     FQ+Y  YC N P+     S    L     F
Sbjct: 1343 IFLKELEKY--EQLPE--DVGHCFVTWADKFQMYVTYCKNKPD-----SNQLILEHAGTF 1393

Query: 402  FEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNV 461
            F+  +    + + S+  +L+ PVQ+I KY L L ELL        + KD    L  M +V
Sbjct: 1394 FDEIQQRHGLAN-SISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKD---GLEVMLSV 1449

Query: 462  AQLINERKR--RLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQR 519
             +  N+      LE  D+         D +GE +L  + ++     L R      K ++R
Sbjct: 1450 PKKANDAMHVSMLEGFDENL-------DVQGELILQDAFQVWDPKSLIR------KGRER 1496

Query: 520  MFFLFDHQLIYCK--KDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHR 577
              FLF+  L++ K  KD        YK +L    L V +  +G            F L  
Sbjct: 1497 HLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGD--------PCKFALWS 1548

Query: 578  GATGDSH---LLCTRKPEQKQRWLK 599
            G T  S    +L     E KQ W+K
Sbjct: 1549 GRTPSSDNKTVLKASNIETKQEWIK 1573


>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
          Length = 1289

 Score =  100 bits (249), Expect = 4e-21
 Identities = 102/389 (26%), Positives = 184/389 (47%), Gaps = 60/389 (15%)

Query: 285 RTNVINEILSTERDYIKHLRDICEGYVRQCRKRA---DMFSEEQLRTIFGNIEDIYRCQK 341
           R  V+NE++ TE+DY+K L  + EG++++  ++    DM  ++++  +FGNI  IY   K
Sbjct: 233 RMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKI--VFGNIHQIYDWHK 290

Query: 342 AFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYF 401
            F  A  ++  +E+  L++L   F++H+    IY  YC N P      S         YF
Sbjct: 291 DFFLAELEKCIQEQDRLAQL---FIKHERKLHIYVWYCQNKPR-----SEYIVAEYDAYF 342

Query: 402 FEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNV 461
            E  + + + + +S   FL+ P+Q+I KY L L + L+Y+     +  D+E A+  M   
Sbjct: 343 EEVKQEINQRLTLS--DFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELM--- 397

Query: 462 AQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMF 521
             L+ +R   + N+ ++  ++ ++   +G+ L     +  Y  EL      Q+++++R  
Sbjct: 398 -CLVPKRCNDMMNLGRLQGFEGTLTA-QGKLL---QQDTFYVIELD--AGMQSRTKERRV 450

Query: 522 FLFDHQLIYCKKDLLRRDVL----YYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHR 577
           FLF+  +I+   +LLR+  L     +K  + M+ L    LE+  D D        F L  
Sbjct: 451 FLFEQIVIF--SELLRKGSLTPGYMFKRSIKMNYLV---LEENVDND-----PCKFALMN 500

Query: 578 GATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTG 637
             T +  +L     + +Q W+    ++  QV            L+ ++  LNA +  +  
Sbjct: 501 RETSERVVLQAANADIQQAWV----QDINQV------------LETQRDFLNALQSPIEY 544

Query: 638 KPKGRRTA---APPPRLP--GPYPADIIP 661
           + K R TA   + P RLP   P P   +P
Sbjct: 545 QRKERSTAVMRSQPARLPQASPRPYSSVP 573


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score = 99.8 bits (247), Expect = 7e-21
 Identities = 80/353 (22%), Positives = 155/353 (43%), Gaps = 35/353 (9%)

Query: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADM--FSEEQLRTIFGNI 333
           E + + +Q    + NE+L TER Y+  L  + + +  +  + A+   F  E +  IF NI
Sbjct: 198 EMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNI 257

Query: 334 EDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLT 393
             I      F+    ++  +E      +G    +     ++Y EY     NA   +  +T
Sbjct: 258 SSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMT 317

Query: 394 -KLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVE 452
            ++ ++    E  +  +    ++L   +L PVQ+I +Y + L + L+   P   D+ D +
Sbjct: 318 ERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAK 377

Query: 453 AALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQP 512
            +L  +   A   N   R++EN+ K+ +    +   E ED++  S+ELI  G++ ++   
Sbjct: 378 KSLEIISTAASHSNSAIRKMENLKKLLEIYEMLG--EEEDIVNPSNELIKEGQILKLAAR 435

Query: 513 QAKSQQRMFFLFDHQLIYC-KKDLLRRDVLYYKGRLDMDGLEVVDLED----------GK 561
              +Q+R  FLF++ L+YC  K  L       + R+ +DG+++V+ ++          GK
Sbjct: 436 NTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGK 495

Query: 562 DRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614
           +R L +   +A                   + K+ W+KA     +      ET
Sbjct: 496 ERTLELQASSA-------------------QDKEEWIKALQETIDAFHQRHET 529


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 95/366 (25%), Positives = 161/366 (43%), Gaps = 26/366 (7%)

Query: 255 DEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQC 314
           +EP  ++ P   +   +D G  AQ S  Q   ++  E+L TE  Y+K L  + + +   C
Sbjct: 132 EEPDSENTPQKAD---KDAGL-AQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVF---C 184

Query: 315 RKRADM-FSEEQLRTIFGNIEDIYRCQKAFV-KALEQRFNRERPHLSELGACFLEHQADF 372
            +  D     E +  IF NI  I+R    F+   L+ R   E      LG    +     
Sbjct: 185 TRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKLAPFL 244

Query: 373 QIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMI---DISLDGFLLTPVQKICK 429
           ++Y EY  N   A   +S  T+ S    F +    +QK     +++L   +L PVQ++ +
Sbjct: 245 KMYGEYVKNFDRAVGLVSTWTQRSPL--FKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPR 302

Query: 430 YPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWE 489
           Y L L + LK       D KD E +L  +   A   N   R++E + K+ +    +    
Sbjct: 303 YELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGG-- 360

Query: 490 GEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDL-LRRDVLYYKGRLD 548
            ED++  ++ELI  G++ +++      Q R  FLF+  ++YC   L L       + ++D
Sbjct: 361 EEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMD 420

Query: 549 MDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQV 608
           + GL+V D+   K    H  I    +        S  L TR  E+K+ W++      E+ 
Sbjct: 421 ISGLQVQDIV--KPNTAHTFIITGRK-------RSLELQTRTEEEKKEWIQIIQATIEKH 471

Query: 609 QLDQET 614
           + + ET
Sbjct: 472 KQNSET 477


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,160,230
Number of Sequences: 37866
Number of extensions: 1371717
Number of successful extensions: 5795
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 222
Number of HSP's successfully gapped in prelim test: 129
Number of HSP's that attempted gapping in prelim test: 5130
Number of HSP's gapped (non-prelim): 589
length of query: 670
length of database: 18,247,518
effective HSP length: 109
effective length of query: 561
effective length of database: 14,120,124
effective search space: 7921389564
effective search space used: 7921389564
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.