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Search of human proteins with 149773484
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149773484 leucine rich repeat and fibronectin type III
domain containing 1 [Homo sapiens]
(771 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149773484 leucine rich repeat and fibronectin type III domain... 1543 0.0
gi|31542244 leucine rich repeat and fibronectin type III domain ... 678 0.0
gi|13375646 leucine rich repeat and fibronectin type III domain ... 643 0.0
gi|55741571 leucine rich repeat and fibronectin type III domain ... 639 0.0
gi|27363458 leucine rich repeat and fibronectin type III domain ... 560 e-159
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 151 3e-36
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 150 6e-36
gi|51317373 netrin-G1 ligand [Homo sapiens] 147 3e-35
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 145 2e-34
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 138 2e-32
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 132 1e-30
gi|109150416 peroxidasin [Homo sapiens] 131 3e-30
gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 127 3e-29
gi|126517478 peroxidasin homolog-like [Homo sapiens] 127 3e-29
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 124 4e-28
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 124 4e-28
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 120 4e-27
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 116 9e-26
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 114 3e-25
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 114 3e-25
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 114 3e-25
gi|188528675 slit homolog 1 [Homo sapiens] 105 1e-22
gi|194440719 chondroadherin-like [Homo sapiens] 102 2e-21
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 100 9e-21
gi|193083136 leucine-rich repeat, immunoglobulin-like and transm... 99 1e-20
gi|225579152 insulin-like growth factor binding protein, acid la... 98 3e-20
gi|62988340 leucine rich repeat containing 22 [Homo sapiens] 97 7e-20
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 97 7e-20
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 96 1e-19
gi|88702793 slit-like 2 [Homo sapiens] 96 1e-19
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 1543 bits (3994), Expect = 0.0
Identities = 771/771 (100%), Positives = 771/771 (100%)
Query: 1 MAPGPFSSALLSPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVP 60
MAPGPFSSALLSPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVP
Sbjct: 1 MAPGPFSSALLSPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVP 60
Query: 61 PAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHL 120
PAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHL
Sbjct: 61 PAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHL 120
Query: 121 DSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWE 180
DSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWE
Sbjct: 121 DSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWE 180
Query: 181 AVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPK 240
AVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPK
Sbjct: 181 AVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPK 240
Query: 241 PPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPL 300
PPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPL
Sbjct: 241 PPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPL 300
Query: 301 ITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTIT 360
ITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTIT
Sbjct: 301 ITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTIT 360
Query: 361 TLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGAN 420
TLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGAN
Sbjct: 361 TLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGAN 420
Query: 421 DSAAERRLVAAELTSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFLV 480
DSAAERRLVAAELTSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFLV
Sbjct: 421 DSAAERRLVAAELTSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFLV 480
Query: 481 NDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAI 540
NDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAI
Sbjct: 481 NDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAI 540
Query: 541 GGVIVASVLVFIVLLMIRYKVYGDGDSRRVKGSRSLPRVSHVCSQTNGAGTGAAQAPALP 600
GGVIVASVLVFIVLLMIRYKVYGDGDSRRVKGSRSLPRVSHVCSQTNGAGTGAAQAPALP
Sbjct: 541 GGVIVASVLVFIVLLMIRYKVYGDGDSRRVKGSRSLPRVSHVCSQTNGAGTGAAQAPALP 600
Query: 601 AQDHYEALREVESQAAPAVAVEAKAMEAETASAEPEVVLGRSLGGSATSLCLLPSEETSG 660
AQDHYEALREVESQAAPAVAVEAKAMEAETASAEPEVVLGRSLGGSATSLCLLPSEETSG
Sbjct: 601 AQDHYEALREVESQAAPAVAVEAKAMEAETASAEPEVVLGRSLGGSATSLCLLPSEETSG 660
Query: 661 EESRAAVGPRRSRSGALEPPTSAPPTLALVPGGAAARPRPQQRYSFDGDYGALFQSHSYP 720
EESRAAVGPRRSRSGALEPPTSAPPTLALVPGGAAARPRPQQRYSFDGDYGALFQSHSYP
Sbjct: 661 EESRAAVGPRRSRSGALEPPTSAPPTLALVPGGAAARPRPQQRYSFDGDYGALFQSHSYP 720
Query: 721 RRARRTKRHRSTPHLDGAGGGAAGEDGDLGLGSARACLAFTSTEWMLESTV 771
RRARRTKRHRSTPHLDGAGGGAAGEDGDLGLGSARACLAFTSTEWMLESTV
Sbjct: 721 RRARRTKRHRSTPHLDGAGGGAAGEDGDLGLGSARACLAFTSTEWMLESTV 771
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 678 bits (1750), Expect = 0.0
Identities = 361/673 (53%), Positives = 465/673 (69%), Gaps = 36/673 (5%)
Query: 20 FLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAA 79
F L L A + Q CP RC+CQ ++P L LCAK GLLFVPP IDRR VELRL DNF+
Sbjct: 6 FYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTN 65
Query: 80 VRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNL 139
++R+DFANMTSLV LTLSRNTI + AFADLR LRALHL+SNRL ++ D GL NL
Sbjct: 66 IKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNL 125
Query: 140 RHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLID 199
HLIL NNQ+ + S AFD + +E+LDLSYNNLE +PW+AV +MV+L+TL+LDHN+ID
Sbjct: 126 HHLILNNNQLTLISSTAFDDVFA-LEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMID 184
Query: 200 HIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQ---GTGPKPPTPLTVSFGGNPLHC 256
+I +GTF LHK+ RLD+TSN+L KLPPD LF R+Q +G P+ +SFGGNPLHC
Sbjct: 185 NIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHC 244
Query: 257 NCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQA 316
NCELLWLRRL+REDDLETCA+P LT RYFWSIPEEEFLCEPPLITR V+EGQ
Sbjct: 245 NCELLWLRRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTH-EMRVLEGQR 303
Query: 317 VSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAA 376
+LRC+A GDPEP +HW++P+G+L+ N++R+ V +GTLD+ ITT++D+G FTCIASN A
Sbjct: 304 ATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPA 363
Query: 377 GEATAPVEVCVVPLP-LMAPPPAAPPPLTEPGSSDIATPGRPGANDSAA-------ERRL 428
GEAT V++ ++ LP L+ P +PGSSDI+T + G+N S++ + ++
Sbjct: 364 GEATQIVDLHIIKLPHLLNSTNHIHEP--DPGSSDISTSTKSGSNTSSSNGDTKLSQDKI 421
Query: 429 VAAELTSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFLVNDLAAGRA 488
V AE TS++ L+++ QR +PGIRM+Q+QYN + DD+LVYRMIP TS+TFLVN+LAAG
Sbjct: 422 VVAEATSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGTM 481
Query: 489 YDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASV 548
YDLCVLA+YDDG T+L ATRVVGC+QFTT D C +++ FLGGTMII IGG+IVASV
Sbjct: 482 YDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVASV 541
Query: 549 LVFIVLLMIRYKVYGDGDSRRVKGSRSLPRVSHVCSQTNGAGTGAAQAPALPAQDHYEAL 608
LVFI++LMIRYKV + G + +VS+V SQTNGA LP +A+
Sbjct: 542 LVFIIILMIRYKVCNN------NGQHKVTKVSNVYSQTNGAQIQGCSV-TLPQSVSKQAV 594
Query: 609 REVESQAAPAVAVEAKAMEAETASAEPEVVLGRSLGGSATSLCLLPSEETSGEESRAAVG 668
E+ + +ET S++ S+T+ LP TS +V
Sbjct: 595 GHEENAQCCKATSDNVIQSSETCSSQ----------DSSTTTSALPPSWTSS----TSVS 640
Query: 669 PRRSRSGALEPPT 681
++ R +P T
Sbjct: 641 QKQKRKTGTKPST 653
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 643 bits (1659), Expect = 0.0
Identities = 349/609 (57%), Positives = 421/609 (69%), Gaps = 41/609 (6%)
Query: 12 SPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELR 71
SPP +A P PCP RC CQ + L++LC GLLFVPP++DRR ELR
Sbjct: 18 SPPQSATP------------SPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELR 65
Query: 72 LTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGD 131
L DNFIA+VRRRD ANMT L+HL+LSRNTI VAAGAFADLRALRALHLD NRL +
Sbjct: 66 LADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEG 125
Query: 132 QLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTL 191
QLRGL NLRHLIL NNQ+ + + A D T+EDLDLSYNNLE LPWEA+G++ N+NTL
Sbjct: 126 QLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTL 185
Query: 192 TLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLR----SQGTGPKPPTPLTV 247
LDHNL+ + G F +LHKL RLDMTSNRL +PPD LF R ++ G P + L +
Sbjct: 186 GLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRG-SPASALVL 244
Query: 248 SFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGG 307
+FGGNPLHCNCEL+WLRRL REDDLE CA+P L RYFW++ EEEF+CEPP++T ++
Sbjct: 245 AFGGNPLHCNCELVWLRRLAREDDLEACASPPALGGRYFWAVGEEEFVCEPPVVTHRSPP 304
Query: 308 RALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGT 367
A V G+ +LRCRAVGDPEP V WV+P GRLLGNSSR R +GTL++ +T D G
Sbjct: 305 LA-VPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGDGGI 363
Query: 368 FTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEP---GSSDIATPGRPGANDSAA 424
FTCIA+NAAGEATA VE+ V P P PP A +P G D TP P A ++A
Sbjct: 364 FTCIAANAAGEATAAVELTVGPPP---PPQLANSTSCDPPRDGDPDALTP--PSAASASA 418
Query: 425 ---------ERRLVAAELTSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTS 475
+R + E + + L++WP QRP+PGIRMYQ+QYNSS DD LVYRMIP+ S
Sbjct: 419 KVADTGPPTDRGVQVTEHGATAALVQWPDQRPIPGIRMYQIQYNSSADDILVYRMIPAES 478
Query: 476 QTFLVNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGT 535
++FL+ DLA+GR YDLCVLAVY+D AT L ATR VGC +F+T PC A FLGGT
Sbjct: 479 RSFLLTDLASGRTYDLCVLAVYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFLGGT 538
Query: 536 MIIAIGGVIVASVLVFIVLLMIRYKVYGDGDSRRVKGSRSLPR-VSHVCSQTNGAGTGAA 594
MIIA+GGVIVASVLVFI +L++RYKV+G + G +P VS VCSQTNGA G
Sbjct: 539 MIIALGGVIVASVLVFIFVLLMRYKVHGG----QPPGKAKIPAPVSSVCSQTNGA-LGPT 593
Query: 595 QAPALPAQD 603
PA PA +
Sbjct: 594 PTPAPPAPE 602
>gi|55741571 leucine rich repeat and fibronectin type III domain
containing 2 [Homo sapiens]
Length = 789
Score = 639 bits (1647), Expect = 0.0
Identities = 370/787 (47%), Positives = 482/787 (61%), Gaps = 67/787 (8%)
Query: 34 CPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLVH 93
CP C+CQN++ +L LC GLLFVPP IDRR VELRL NFI + R+DFANMT LV
Sbjct: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
Query: 94 LTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVE 153
LTLSRNTI + +F DL +LR+LHLDSNRL + D LRGL NL+HLI+ NNQ+ +
Sbjct: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
Query: 154 SAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLV 213
AF+ FL T+EDLDLSYNNL LPW++V +MVNL+ L+LDHNL+DHIAEGTF L KL
Sbjct: 141 DEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLA 200
Query: 214 RLDMTSNRLHKLPPDGLFLRSQGTG----PKPPTPLTVSFGGNPLHCNCELLWLRRLTRE 269
RLD+TSNRL KLPPD +F RSQ + P P PL+ SFGGNPLHCNCELLWLRRL R+
Sbjct: 201 RLDLTSNRLQKLPPDPIFARSQASALTATPFAP-PLSFSFGGNPLHCNCELLWLRRLERD 259
Query: 270 DDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEP 329
DDLETC +P L RYFW + EEEF+CEPPLIT Q + LV+EGQA +L+C+A+GDP P
Sbjct: 260 DDLETCGSPGGLKGRYFWHVREEEFVCEPPLIT-QHTHKLLVLEGQAATLKCKAIGDPSP 318
Query: 330 VVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVP 389
++HWVAPD RL+GNSSRT V +GTLD+ ITT +DSG FTCIA+NAAGEATA VEV +V
Sbjct: 319 LIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQ 378
Query: 390 LPLM-------APPPAAPPPLTEPGSSDIATPGRPGAN--DSAAERRLVAAELTSNSVLI 440
LP + APP + +T + G G S ER ++ +E+T+ S L+
Sbjct: 379 LPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPKSPPERAVLVSEVTTTSALV 438
Query: 441 RWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDG 500
+W + P ++MYQ+QYN S D+ L+YRMIP++++ F+VN+L +G YDLCVLA++DD
Sbjct: 439 KWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNNLVSGTGYDLCVLAMWDDT 498
Query: 501 ATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASVLVFIVLLMIRYK 560
AT L AT +VGC QF T D C+ + + LGGTMI+ IGG+IVA++LVFIV+LM+RYK
Sbjct: 499 ATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIVATLLVFIVILMVRYK 558
Query: 561 VYGDGDSRRVKGSRSLPRVSHVCSQTNGAGTGAAQAPALPAQDHYEALREVESQAAPAVA 620
V S+ VS+V SQTNGA + A V ++ A
Sbjct: 559 V-----CNHEAPSKMAAAVSNVYSQTNGAQPPPPSSAPAGAPPQGPPKVVVRNELLDFTA 613
Query: 621 VEAKAMEAETASA---------------------EPEVVLGRSLGGSAT-------SLCL 652
A+A ++ ++S+ P+ L R +G A+ L
Sbjct: 614 SLARASDSSSSSSLGSGEAAGLGRAPWRIPPSAPRPKPSLDRLMGAFASLDLKSQRKEEL 673
Query: 653 LPSEETSGE-ESRAAVGPRRSRSGALEPPTSAPPTLALVPGGAAARPRPQQRYSFD-GDY 710
L S +G +A G R L PP + +L +P + ++ +SFD GD+
Sbjct: 674 LDSRTPAGRGAGTSARGHHSDREPLLGPPAARARSLLPLP----LEGKAKRSHSFDMGDF 729
Query: 711 ------GALFQSHSYPRRARRTKRHRSTPHLDGAGGGAAGEDGDLGLGSARACLAFTSTE 764
G + +S PR+ RS L G E+ DL A F S+E
Sbjct: 730 AAAAAGGVVPGGYSPPRKVSNIWTKRS---LSVNGMLLPFEESDL----VGARGTFGSSE 782
Query: 765 WMLESTV 771
W++ESTV
Sbjct: 783 WVMESTV 789
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 560 bits (1444), Expect = e-159
Identities = 305/590 (51%), Positives = 384/590 (65%), Gaps = 21/590 (3%)
Query: 17 ALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNF 76
A P LLLL A + P P C+CQN++ +L+ LCA GLLFVPP +DRR VELRL DNF
Sbjct: 2 APPLLLLLLASGAAACPLP--CVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNF 59
Query: 77 IAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGL 136
I A+ DF NMT LV LTLSRN I ++ A AF DL +LR+LHLD NRL E+ LRG
Sbjct: 60 IQALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGP 119
Query: 137 GNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHN 196
NL+HLIL NQ+ R+ AFD FL ++EDLDLSYNNL +PW +G M L+TL LDHN
Sbjct: 120 VNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHN 179
Query: 197 LIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGGNPLHC 256
LID + G F QL +L RLD+TSNRL L PD LF R + P PL +SF GNPLHC
Sbjct: 180 LIDALPPGAFAQLGQLSRLDLTSNRLATLAPDPLFSRGR-DAEASPAPLVLSFSGNPLHC 238
Query: 257 NCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQA 316
NCELLWLRRL R DDLETCA+P L RYFW++PE EF CEPPLI R R V+EGQ
Sbjct: 239 NCELLWLRRLARPDDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHT-QRLWVLEGQR 297
Query: 317 VSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAA 376
+LRCRA+GDP P +HWV PD RL+GNSSR R +GTL++ +T D+G +TCIA+N A
Sbjct: 298 ATLRCRALGDPAPTMHWVGPDDRLVGNSSRARAFPNGTLEIGVTGAGDAGGYTCIATNPA 357
Query: 377 GEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGANDSA---AERRLVAAEL 433
GEATA VE+ V+ LP A PG SDIA R A +E + E+
Sbjct: 358 GEATARVELRVLALPHGGNSSAEG---GRPGPSDIAASARTAAEGEGTLESEPAVQVTEV 414
Query: 434 TSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFLVNDLAAGRAYDLCV 493
T+ S L+ W RP + M+Q+QYNSS D++L+YR++P++S FL+ L G YDLC+
Sbjct: 415 TATSGLVSWGPGRPADPVWMFQIQYNSSEDETLIYRIVPASSHHFLLKHLVPGADYDLCL 474
Query: 494 LAVYD-DGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASVLVFI 552
LA+ G + L ATR++GC F+T C L+AH LGGT+ +A+GGV+VA++LVF
Sbjct: 475 LALSPAAGPSDLTATRLLGCAHFSTLPASPLCHALQAHVLGGTLTVAVGGVLVAALLVFT 534
Query: 553 VLLMIRYKVYGDGDSRRVKGSRSLPRVSHVCSQTNG--AGTGAAQAPALP 600
V L++R + G+G R ++SHV SQTNG + T A P P
Sbjct: 535 VALLVRGRGAGNG--------RLPLKLSHVQSQTNGGPSPTPKAHPPRSP 576
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 151 bits (381), Expect = 3e-36
Identities = 120/381 (31%), Positives = 158/381 (41%), Gaps = 48/381 (12%)
Query: 69 ELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEV 128
+L + DN + V FA + L LTL R + V A A L AL AL L + +
Sbjct: 160 KLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRL 219
Query: 129 RGDQLRGLGNLRHL---------------ILGNN----QIRR--VESAAFDAF--LSTVE 165
LRGLG L+ L ++G N I R + S F A LS +
Sbjct: 220 PAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLR 279
Query: 166 DLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKL 225
LDLS N + A+P + +V L L L + IA F L LD+ N L L
Sbjct: 280 VLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTL 339
Query: 226 PPDGLFLRSQGTGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDL----ETCATPEHL 281
P P +T+ GNPL C+C LLWL RL R D CA P H+
Sbjct: 340 EETAF--------PSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHV 391
Query: 282 TDRYFWS----IPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPD 337
+ +P F C+P LI + + EG C GDP P V W+ P
Sbjct: 392 QGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPH 451
Query: 338 GRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPP 397
G LG + R RV DGTL++ LRD G + C+ SN AG + + V+ +
Sbjct: 452 GAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQV------- 504
Query: 398 AAPPPLTEPGSSDIATPGRPG 418
PP +I PG PG
Sbjct: 505 --EPPNGTLSDPNITVPGIPG 523
Score = 68.2 bits (165), Expect = 3e-11
Identities = 64/218 (29%), Positives = 97/218 (44%), Gaps = 5/218 (2%)
Query: 13 PPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRL 72
PP L FLLLL G+ G CP C C + +LC L VP + L L
Sbjct: 12 PPWPPLLFLLLLPGGS--GGSCPAVCDC--TSQPQAVLCGHRQLEAVPGGLPLDTELLDL 67
Query: 73 TDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQ 132
+ N + +++ + ++ L L LS N + + GAF L++L L L NRL +
Sbjct: 68 SGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGV 127
Query: 133 LRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLT 192
GL L L L NQI AF L +++ L++ N+L + A + L+TLT
Sbjct: 128 FSGLSALTLLDLRLNQIVLFLDGAFGE-LGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLT 186
Query: 193 LDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGL 230
L+ + + +L LV L + + +LP L
Sbjct: 187 LERCNLSTVPGLALARLPALVALRLRELDIGRLPAGAL 224
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 150 bits (378), Expect = 6e-36
Identities = 131/435 (30%), Positives = 181/435 (41%), Gaps = 79/435 (18%)
Query: 10 LLSPPPAALPFLLLLWAGASRGQP----CPGRCICQNVAPTLTMLCAKTGLLFVPPAIDR 65
L SPP A + + + A G P CP C C N A + +C + L VP +I
Sbjct: 29 LFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASRV--ICTRRDLAEVPASIPV 86
Query: 66 RVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRL 125
L L +N I +R F ++ L L LS+N + ++ GAF L +L L L NRL
Sbjct: 87 NTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRL 146
Query: 126 AEVRGDQLRGLGNLRHLILGNNQIRRVESAAFD----------------------AF--- 160
V L LR L L NN I + S AF+ AF
Sbjct: 147 TTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGL 206
Query: 161 ---------------------LSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLID 199
L +E+L+LS N L+ + + + +L L L H +
Sbjct: 207 VNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVA 266
Query: 200 HIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPL----TVSFGGNPLH 255
I F L L L+++ N L LP D LF TPL V NP H
Sbjct: 267 TIERNAFDDLKSLEELNLSHNNLMSLPHD-LF-----------TPLHRLERVHLNHNPWH 314
Query: 256 CNCELLWLRRLTREDDLET------CATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRA 309
CNC++LWL +E C P L RY + + F C P+I
Sbjct: 315 CNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLN 374
Query: 310 LVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSS---RTRVRGDGTLDVTITTLRDSG 366
V EG A L+CR G V+W+ P+G L+ + S R V DGTL+ T T++D+G
Sbjct: 375 -VTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTG 432
Query: 367 TFTCIASNAAGEATA 381
+TC+ +N+AG TA
Sbjct: 433 QYTCMVTNSAGNTTA 447
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 147 bits (372), Expect = 3e-35
Identities = 130/439 (29%), Positives = 184/439 (41%), Gaps = 77/439 (17%)
Query: 4 GP-FSSALLSPPPAALPFL-LLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPP 61
GP F+ AL P L L LL+ AG R Q CP C C N + +C + L VP
Sbjct: 15 GPRFNRALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKV--ICVRKNLREVPD 72
Query: 62 AIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLD 121
I L L +N I ++ F ++ L L LSRN I + GAF L L L L
Sbjct: 73 GISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELF 132
Query: 122 SNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAF--------------------- 160
NRL + L L+ L L NN I + S AF+
Sbjct: 133 DNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGA 192
Query: 161 -------------------------LSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDH 195
L +++LDLS N+L A+ + +++L L +
Sbjct: 193 FEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQ 252
Query: 196 NLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPL----TVSFGG 251
+ I I F L LV +++ N L LP D LF TPL +
Sbjct: 253 SQIQVIERNAFDNLQSLVEINLAHNNLTLLPHD-LF-----------TPLHHLERIHLHH 300
Query: 252 NPLHCNCELLWLRRLTRE---DDLETCA---TPEHLTDRYFWSIPEEEFLCEPPLITRQA 305
NP +CNC++LWL ++ + CA TP +L RY + + F C P+I
Sbjct: 301 NPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPP 360
Query: 306 GGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSS---RTRVRGDGTLDVTITTL 362
V EG A L+CRA V W+ P+G ++ + + R V DGTL+ T T+
Sbjct: 361 ADLN-VTEGMAAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTV 418
Query: 363 RDSGTFTCIASNAAGEATA 381
+D+G +TC+ SN+ G TA
Sbjct: 419 QDTGMYTCMVSNSVGNTTA 437
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 145 bits (365), Expect = 2e-34
Identities = 111/348 (31%), Positives = 157/348 (45%), Gaps = 27/348 (7%)
Query: 70 LRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVR 129
L + DN + V RR FA + +L LTL R + ++ + LR+L AL L +A +
Sbjct: 155 LEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLE 214
Query: 130 GDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLN 189
R L L HL + N + E AA + L +++ N+ A+P A+ +L
Sbjct: 215 DQNFRRLPGLLHLEIDNWPLLE-EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLT 273
Query: 190 TLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDG----------------LFLR 233
L L HN I + G+F L +L L + L + P L
Sbjct: 274 CLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTL 333
Query: 234 SQGTGPKPPTPLTVSFGGNPLHCNCELLWL--RRLTREDD--LETCATPEHLTDRYFWSI 289
+ T T T+ GNPL C+C LLW+ RR T D L CATP + ++
Sbjct: 334 EESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALRNL 393
Query: 290 PE----EEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSS 345
P+ E F+C P I + R G+ V CRA G+P P V WV P R + +S
Sbjct: 394 PDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATS 453
Query: 346 --RTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLP 391
R RV GTL++ +DSGT+TC+ASNA G T + V P P
Sbjct: 454 AGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTVRPEP 501
Score = 81.6 bits (200), Expect = 2e-15
Identities = 74/225 (32%), Positives = 101/225 (44%), Gaps = 28/225 (12%)
Query: 17 ALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNF 76
+LP LLL A G CP RC C T + C + L VP I L L+ N
Sbjct: 9 SLPLLLLPAAPPPAGG-CPARCEC--TVQTRAVACTRRRLTAVPDGIPAETRLLELSRNR 65
Query: 77 IAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEV------RG 130
I + D A + +L L LS N I V GAFA+L LR L L N+L + R
Sbjct: 66 IRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRL 125
Query: 131 DQL------------------RGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYN 172
D L + L +LR L +G+N + V AF A L +E+L L
Sbjct: 126 DNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAF-AGLLALEELTLERC 184
Query: 173 NLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDM 217
NL AL E++G + +L L L H I + + F +L L+ L++
Sbjct: 185 NLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEI 229
Score = 38.9 bits (89), Expect = 0.018
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 1/83 (1%)
Query: 140 RHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLID 199
R L L N+IR + A L +E+LDLS N + + A + L L L N +
Sbjct: 57 RLLELSRNRIRCLNPGDLAA-LPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLK 115
Query: 200 HIAEGTFVQLHKLVRLDMTSNRL 222
I G F +L L LD++ N+L
Sbjct: 116 LIPPGVFTRLDNLTLLDLSENKL 138
Score = 38.5 bits (88), Expect = 0.024
Identities = 27/84 (32%), Positives = 39/84 (46%), Gaps = 1/84 (1%)
Query: 150 RRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQL 209
RR +A D + L+LS N + L + + L L L N I H+ G F L
Sbjct: 42 RRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANL 101
Query: 210 HKLVRLDMTSNRLHKLPPDGLFLR 233
+L L + N+L +PP G+F R
Sbjct: 102 PRLRVLRLRGNQLKLIPP-GVFTR 124
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 138 bits (348), Expect = 2e-32
Identities = 106/346 (30%), Positives = 155/346 (44%), Gaps = 31/346 (8%)
Query: 70 LRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVR 129
L + DN + + R F+ + SL LTL + + V A + LR+L +LHL + +
Sbjct: 158 LEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMP 217
Query: 130 GDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLN 189
+ L +L+HL + + + A + + L ++ NL +P+ A +V L
Sbjct: 218 VYAFKRLFHLKHLEIDYWPLLDMMPAN-SLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLT 276
Query: 190 TLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGL----FLR------------ 233
L L +N I I G F L +L L + +L + P FLR
Sbjct: 277 HLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETL 336
Query: 234 SQGTGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLE------TCATPEHLTDRYFW 287
+ P +S NPL C+C LLW+ L R+ L+ CA P+ + +R F
Sbjct: 337 EENVFSSPRALEVLSINNNPLACDCRLLWI--LQRQPTLQFGGQQPMCAGPDTIRERSFK 394
Query: 288 SIPEEE----FLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGN 343
F C+ P I + LV EGQ V L C A GDP+PV+ WV P R +
Sbjct: 395 DFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITT 454
Query: 344 SS--RTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCV 387
S R V GDGTL++ +DSG + CIASNAAG T + V
Sbjct: 455 KSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
Score = 76.3 bits (186), Expect = 1e-13
Identities = 68/227 (29%), Positives = 103/227 (45%), Gaps = 33/227 (14%)
Query: 19 PFL----LLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTD 74
PFL +L++ G++ G CP RC C A ++ C + L+ +P I L L+
Sbjct: 11 PFLGLAVVLIFMGSTIG--CPARCECS--AQNKSVSCHRRRLIAIPEGIPIETKILDLSK 66
Query: 75 NFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLR 134
N + +V +F + L + LS N I V GAF +L LR+L L NRL V
Sbjct: 67 NRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFT 126
Query: 135 GLG------------------------NLRHLILGNNQIRRVESAAFDAFLSTVEDLDLS 170
GL NL+ L +G+N + + AF LS +E L L
Sbjct: 127 GLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLS-LEQLTLE 185
Query: 171 YNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDM 217
NL A+P EA+ + +L +L L H I+++ F +L L L++
Sbjct: 186 KCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEI 232
Score = 47.8 bits (112), Expect = 4e-05
Identities = 28/93 (30%), Positives = 46/93 (49%)
Query: 67 VVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLA 126
+ L +T+ ++ V F ++ L HL LS N I + AG F+DL L+ LH+ +L
Sbjct: 251 LTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLR 310
Query: 127 EVRGDQLRGLGNLRHLILGNNQIRRVESAAFDA 159
+ +GL LR L + N + +E F +
Sbjct: 311 TIEPHSFQGLRFLRVLNVSQNLLETLEENVFSS 343
Score = 38.1 bits (87), Expect = 0.031
Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 1/81 (1%)
Query: 142 LILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHI 201
L L N+++ V F ++ +E++DLS N + + A + NL +L L N + +
Sbjct: 62 LDLSKNRLKSVNPEEFISY-PLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLV 120
Query: 202 AEGTFVQLHKLVRLDMTSNRL 222
G F L L +LD++ N++
Sbjct: 121 PLGVFTGLSNLTKLDISENKI 141
Score = 34.3 bits (77), Expect = 0.45
Identities = 29/82 (35%), Positives = 39/82 (47%), Gaps = 6/82 (7%)
Query: 167 LDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLP 226
LDLS N L+++ E L + L N+I ++ G F L L L + NRL KL
Sbjct: 62 LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRL-KLV 120
Query: 227 PDGLFLRSQGTGPKPPTPLTVS 248
P G+F TG T L +S
Sbjct: 121 PLGVF-----TGLSNLTKLDIS 137
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 132 bits (332), Expect = 1e-30
Identities = 124/434 (28%), Positives = 178/434 (41%), Gaps = 87/434 (20%)
Query: 18 LPFLLL---LW-------AGASRG-QPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRR 66
LPF+ L +W A AS G Q CP C C N + +C + GL VP I
Sbjct: 19 LPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKV--VCTRRGLSEVPQGIPSN 76
Query: 67 VVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLA 126
L L +N I ++ F ++ L L L RN+I Q+ GAF L +L L L N L
Sbjct: 77 TRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLT 136
Query: 127 EVRGDQLRGLGNLRHLILGNNQIRRVESAAFD----------------------AF---- 160
+ L LR L L NN I + S AF+ AF
Sbjct: 137 VIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLF 196
Query: 161 --------------------LSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDH 200
L +E+L++S N+ + + + +L L + ++ +
Sbjct: 197 NLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSL 256
Query: 201 IAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLT----VSFGGNPLHC 256
I F L LV L++ N L LP D LF TPL + NP +C
Sbjct: 257 IERNAFDGLASLVELNLAHNNLSSLPHD-LF-----------TPLRYLVELHLHHNPWNC 304
Query: 257 NCELLWLRRLTRE------DDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRAL 310
+C++LWL RE C P H+ RY + + F C P I A
Sbjct: 305 DCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIM-DAPRDLN 363
Query: 311 VVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSR---TRVRGDGTLDVTITTLRDSGT 367
+ EG+ L+CR P V W+ P+G +L ++SR V DGTL+ + L D+G
Sbjct: 364 ISEGRMAELKCRT--PPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGV 421
Query: 368 FTCIASNAAGEATA 381
+TC+ +N AG + A
Sbjct: 422 YTCMVTNVAGNSNA 435
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 131 bits (329), Expect = 3e-30
Identities = 111/389 (28%), Positives = 165/389 (42%), Gaps = 76/389 (19%)
Query: 31 GQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTS 90
G CP RC+C T+ C LL PA+ A TS
Sbjct: 33 GAGCPSRCLCFRT----TVRCMHL-LLEAVPAV----------------------APQTS 65
Query: 91 LVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIR 150
++ L +R I ++ GAF LR L L L++N++ + L NL++L L N+I+
Sbjct: 66 ILDLRFNR--IREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQ 123
Query: 151 RVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLH 210
++ AF L+++E L L +N +E L ++ + L L L +N I H+ GTF L
Sbjct: 124 SIDRQAFKG-LASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLE 182
Query: 211 KLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGGNPLHCNCELLWLRRLTRE- 269
+ RL + SN LH C+CE+LWL L +
Sbjct: 183 SMKRLRLDSNTLH--------------------------------CDCEILWLADLLKTY 210
Query: 270 ------DDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRA 323
C P + R +I EE CE P IT + A V G V CRA
Sbjct: 211 AESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQD-ADVTSGNTVYFTCRA 269
Query: 324 VGDPEPVVHWVAPDGRL-LGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAP 382
G+P+P + W+ + L + SR + DGTL + T D G + C+A N AGE
Sbjct: 270 EGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGE---- 325
Query: 383 VEVCVVPLPLMAPPPAAPPPLTEPGSSDI 411
V+ V L PA P + +P ++++
Sbjct: 326 VKTQEVTLRYFG-SPARPTFVIQPQNTEV 353
Score = 52.0 bits (123), Expect = 2e-06
Identities = 31/91 (34%), Positives = 42/91 (46%), Gaps = 3/91 (3%)
Query: 310 LVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFT 369
+V+EGQ V +C A G+P PV+ W G L R V GTL ++ L D G +
Sbjct: 443 VVIEGQTVDFQCEAKGNPPPVIAW-TKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYE 501
Query: 370 CIASNAAGEATAPVEVCVVP--LPLMAPPPA 398
C A N G + V P P+ A P+
Sbjct: 502 CQAVNIIGSQKVVAHLTVQPRVTPVFASIPS 532
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/74 (29%), Positives = 36/74 (48%), Gaps = 1/74 (1%)
Query: 314 GQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIAS 373
G V L C + G+PEP + W DG + S + + +G L + D+G + C+A
Sbjct: 539 GANVQLPCSSQGEPEPAITW-NKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVAR 597
Query: 374 NAAGEATAPVEVCV 387
N G A+ + + V
Sbjct: 598 NTIGSASVSMVLSV 611
>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
Length = 513
Score = 127 bits (320), Expect = 3e-29
Identities = 130/450 (28%), Positives = 177/450 (39%), Gaps = 68/450 (15%)
Query: 15 PAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTD 74
PA LP LLLL + G CP C C + T+ C L VP I L L D
Sbjct: 6 PALLPLLLLLLPLRAAG--CPAACRCYSA----TVECGALRLRVVPLGIPPGTQTLFLQD 59
Query: 75 NFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLR 134
N IA + A + +L L L N++ + AGAF L L L SNRL +R
Sbjct: 60 NNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFV 119
Query: 135 GLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLD 194
GL LR L L NQ+ R+ F L +++L L N++E L +A+ + +L L L
Sbjct: 120 GLAQLRVLYLAGNQLARLLDFTF-LHLPRLQELHLQENSIELLEDQALAGLSSLALLDLS 178
Query: 195 HNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGGNPL 254
N + I+ L L L +T N P
Sbjct: 179 RNQLGTISREALQPLASLQVLRLTEN--------------------------------PW 206
Query: 255 HCNCELLWL---------RRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQA 305
C+C L WL R LT D CA P L + + +C PP + Q
Sbjct: 207 RCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPPSVHVQP 266
Query: 306 GGRALVVEGQAVSLRCRAVGDPEPVVHW--------------VAPDGRLLGNSSRTRV-R 350
+ G+ + + C+A G P+P+V W +G LLG +
Sbjct: 267 LELTANL-GEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGHSASDT 325
Query: 351 GDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSD 410
G G L ++ TL +G + C ASNA G A P + V PA PPP P +
Sbjct: 326 GSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPP---PAARP 382
Query: 411 IATPGRPGANDSAAERRLVAAELTSNSVLI 440
+ RP A S A R L A T+ + I
Sbjct: 383 AGSEPRPEAG-SMAFRALGVATQTAIAAAI 411
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 127 bits (320), Expect = 3e-29
Identities = 105/367 (28%), Positives = 150/367 (40%), Gaps = 71/367 (19%)
Query: 21 LLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAV 80
L LL G PCP RC+C T+ C L +P + V
Sbjct: 11 LFLLAGWCLPGLPCPSRCLCFKS----TVRCMHLMLDHIPQVPQQTTV------------ 54
Query: 81 RRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLR 140
L L N I ++ AF L+ L L L++N + ++ + GL NL
Sbjct: 55 -------------LDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLL 101
Query: 141 HLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDH 200
+L L N+I ++ F +S +E L + +N LE L E G ++ L L L +N +
Sbjct: 102 YLYLYKNEIHALDKQTFKGLIS-LEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSK 160
Query: 201 IAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGGNPLHCNCEL 260
I G+F L L RL + SN L C+C+L
Sbjct: 161 IPAGSFSNLDSLKRLRLDSNALV--------------------------------CDCDL 188
Query: 261 LWLRRLTR-------EDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVE 313
+WL L + TC P L R S+ EEF C+ P IT + V
Sbjct: 189 MWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQD-VEVPS 247
Query: 314 GQAVSLRCRAVGDPEPVVHWVAPDGRL-LGNSSRTRVRGDGTLDVTITTLRDSGTFTCIA 372
G V CRA G+P+P + W+ + L L + +R V DGTL + T D G + C+A
Sbjct: 248 GNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMA 307
Query: 373 SNAAGEA 379
N+AGEA
Sbjct: 308 RNSAGEA 314
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 1/83 (1%)
Query: 310 LVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFT 369
+V+E AV C A G+P PV+ W G+L T V GTL + D G +
Sbjct: 429 VVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHT-VLSSGTLRIDRAAQHDQGQYE 487
Query: 370 CIASNAAGEATAPVEVCVVPLPL 392
C A ++ G V++ V P L
Sbjct: 488 CQAVSSLGVKKVSVQLTVKPKAL 510
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/77 (27%), Positives = 40/77 (51%), Gaps = 1/77 (1%)
Query: 314 GQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIAS 373
G+ +++ C A G+P+P++ W +G + S + V +GTL + D G + C+A
Sbjct: 525 GKNINISCHAQGEPQPIITW-NKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVAR 583
Query: 374 NAAGEATAPVEVCVVPL 390
N+ G A + + V +
Sbjct: 584 NSFGLAVTNMFLTVTAI 600
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 124 bits (310), Expect = 4e-28
Identities = 108/398 (27%), Positives = 159/398 (39%), Gaps = 77/398 (19%)
Query: 66 RVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRL 125
+++ L L +N + + FA + SL L L+ N + ++A AF+ L L LHL+SN L
Sbjct: 118 QLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLL 177
Query: 126 AEVRGD------------------------QLRGLGNLRHLILGNNQIRRVESAAFDAFL 161
+ R L NLR L+L +R + A + L
Sbjct: 178 RAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEG-L 236
Query: 162 STVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTF--------------- 206
++E L N L +P A+ Q+ L L L+ N + + G F
Sbjct: 237 QSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNME 296
Query: 207 ----------VQLHKLVRLDMTSN---------RLHKLPP--------DGLFLRSQGTGP 239
V L +L +LD+T+N H LP + L Q T
Sbjct: 297 ELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVE 356
Query: 240 KPPTPLTVSFGGNPLHCNCELLWLRRL-TR----EDDLETCATPEHLTDRYFWSIPEEEF 294
P V GNP+ C+C + W TR E CA P L +P E
Sbjct: 357 SLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREM 416
Query: 295 L--CEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNS---SRTRV 349
C P + R V G+++ L CRA+ +PEP ++WV P G L + R RV
Sbjct: 417 TDHCLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRV 476
Query: 350 RGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCV 387
+GTL++ T ++G +TC+A N G T V V V
Sbjct: 477 YPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
Score = 81.3 bits (199), Expect = 3e-15
Identities = 66/222 (29%), Positives = 96/222 (43%), Gaps = 18/222 (8%)
Query: 21 LLLLW-AGASRGQP-------CPGRCICQ---------NVAPTLTMLCAKTGLLFVPPAI 63
LLL W AGA+ P CP +C CQ + T+ C L VPPA+
Sbjct: 8 LLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPAL 67
Query: 64 DRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSN 123
L L N I V + + + +L L LS+N+ F L L +LHL+ N
Sbjct: 68 PAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEEN 127
Query: 124 RLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVG 183
+L + GL +L+ L L +NQ+ R+ AF LS + L L+ N L A+
Sbjct: 128 QLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSG-LSNLLRLHLNSNLLRAIDSRWFE 186
Query: 184 QMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKL 225
+ NL L + N +D I + F L L L + L ++
Sbjct: 187 MLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREI 228
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 124 bits (310), Expect = 4e-28
Identities = 108/398 (27%), Positives = 159/398 (39%), Gaps = 77/398 (19%)
Query: 66 RVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRL 125
+++ L L +N + + FA + SL L L+ N + ++A AF+ L L LHL+SN L
Sbjct: 118 QLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLL 177
Query: 126 AEVRGD------------------------QLRGLGNLRHLILGNNQIRRVESAAFDAFL 161
+ R L NLR L+L +R + A + L
Sbjct: 178 RAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEG-L 236
Query: 162 STVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTF--------------- 206
++E L N L +P A+ Q+ L L L+ N + + G F
Sbjct: 237 QSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNME 296
Query: 207 ----------VQLHKLVRLDMTSN---------RLHKLPP--------DGLFLRSQGTGP 239
V L +L +LD+T+N H LP + L Q T
Sbjct: 297 ELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVE 356
Query: 240 KPPTPLTVSFGGNPLHCNCELLWLRRL-TR----EDDLETCATPEHLTDRYFWSIPEEEF 294
P V GNP+ C+C + W TR E CA P L +P E
Sbjct: 357 SLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREM 416
Query: 295 L--CEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNS---SRTRV 349
C P + R V G+++ L CRA+ +PEP ++WV P G L + R RV
Sbjct: 417 TDHCLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRV 476
Query: 350 RGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCV 387
+GTL++ T ++G +TC+A N G T V V V
Sbjct: 477 YPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
Score = 81.3 bits (199), Expect = 3e-15
Identities = 66/222 (29%), Positives = 96/222 (43%), Gaps = 18/222 (8%)
Query: 21 LLLLW-AGASRGQP-------CPGRCICQ---------NVAPTLTMLCAKTGLLFVPPAI 63
LLL W AGA+ P CP +C CQ + T+ C L VPPA+
Sbjct: 8 LLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPAL 67
Query: 64 DRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSN 123
L L N I V + + + +L L LS+N+ F L L +LHL+ N
Sbjct: 68 PAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEEN 127
Query: 124 RLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVG 183
+L + GL +L+ L L +NQ+ R+ AF LS + L L+ N L A+
Sbjct: 128 QLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSG-LSNLLRLHLNSNLLRAIDSRWFE 186
Query: 184 QMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKL 225
+ NL L + N +D I + F L L L + L ++
Sbjct: 187 MLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREI 228
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 120 bits (302), Expect = 4e-27
Identities = 96/345 (27%), Positives = 150/345 (43%), Gaps = 29/345 (8%)
Query: 70 LRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVR 129
L + DN + + R F+ + SL LTL + + + A + L L L L + +R
Sbjct: 172 LEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIR 231
Query: 130 GDQLRGLGNLRHLILGNNQIRRVESAAFDAFLS-TVEDLDLSYNNLEALPWEAVGQMVNL 188
+ L L+ +L + +++ + + L +++ NL A+P+ AV +V L
Sbjct: 232 DYSFKRLYRLK--VLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYL 289
Query: 189 NTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGL----FLRSQGTGPKPPTP 244
L L +N I I +L +L + + +L + P +LR T
Sbjct: 290 RFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTT 349
Query: 245 L------------TVSFGGNPLHCNCELLWLRR----LTREDDLETCATPEHLTDRYFWS 288
L T+ NPL C+C LLW+ R L TCATPE + + F
Sbjct: 350 LEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKD 409
Query: 289 IPE----EEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNS 344
P+ F C I + + V EG V CRA GDP P + W++P L+
Sbjct: 410 FPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAK 469
Query: 345 SRTR--VRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCV 387
S R V DGTL+V ++D+GT+ CIA+NA G + P + V
Sbjct: 470 SNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV 514
Score = 77.4 bits (189), Expect = 5e-14
Identities = 67/226 (29%), Positives = 100/226 (44%), Gaps = 29/226 (12%)
Query: 19 PFLLLLWAGASRGQP--CPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNF 76
P LLL+ G CP RC C A +LC + + VP I L L N
Sbjct: 25 PILLLVLGSVLSGSATGCPPRCECS--AQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNR 82
Query: 77 IAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGL 136
I + + +FA+ L L L+ N + V GAF +L LR L L SNRL + GL
Sbjct: 83 IKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGL 142
Query: 137 G------------------------NLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYN 172
NL+ L +G+N + + AF L+++E L L
Sbjct: 143 SNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSG-LNSLEQLTLEKC 201
Query: 173 NLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMT 218
NL ++P EA+ + L L L H I+ I + +F +L++L L+++
Sbjct: 202 NLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEIS 247
Score = 44.3 bits (103), Expect = 4e-04
Identities = 28/83 (33%), Positives = 45/83 (54%), Gaps = 1/83 (1%)
Query: 140 RHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLID 199
R L LG N+I+ + F +F +E+L+L+ N + A+ A + NL TL L N +
Sbjct: 74 RLLDLGKNRIKTLNQDEFASF-PHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLK 132
Query: 200 HIAEGTFVQLHKLVRLDMTSNRL 222
I G F L L +LD++ N++
Sbjct: 133 LIPLGVFTGLSNLTKLDISENKI 155
Score = 38.1 bits (87), Expect = 0.031
Identities = 28/82 (34%), Positives = 39/82 (47%), Gaps = 6/82 (7%)
Query: 167 LDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLP 226
LDL N ++ L + +L L L+ N++ + G F L L L + SNRL KL
Sbjct: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRL-KLI 134
Query: 227 PDGLFLRSQGTGPKPPTPLTVS 248
P G+F TG T L +S
Sbjct: 135 PLGVF-----TGLSNLTKLDIS 151
Score = 38.1 bits (87), Expect = 0.031
Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 1/108 (0%)
Query: 67 VVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLA 126
+ L +T + AV ++ L L LS N I + +L L+ + L +LA
Sbjct: 265 LTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLA 324
Query: 127 EVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNL 174
V RGL LR L + NQ+ +E + F + + +E L L N L
Sbjct: 325 VVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHS-VGNLETLILDSNPL 371
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 116 bits (290), Expect = 9e-26
Identities = 109/384 (28%), Positives = 157/384 (40%), Gaps = 83/384 (21%)
Query: 66 RVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRL 125
R+ +L L N I + F + SL L L RN I ++ GAF L + LHL+ N L
Sbjct: 212 RLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSL 271
Query: 126 AEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQM 185
EV L GL L L L NN I R+ + +F + +L LS+NNL L E++ ++
Sbjct: 272 VEVNSGSLYGLTALHQLHLSNNSIARIHRKGW-SFCQKLHELVLSFNNLTRLDEESLAEL 330
Query: 186 VNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPD------GLFLRSQGT-- 237
+L+ L L HN I HIAEG F L L LD+ N + D GL S+ T
Sbjct: 331 SSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLF 390
Query: 238 GPKPPTPLTVSF-----------GGNPLH------------------------CNCELLW 262
G K + +F GGN + C+C+L W
Sbjct: 391 GNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKW 450
Query: 263 L-----RRLTREDDLETCATPEHLTDRYFWSIPEEEFLCE----PPLITRQAGGRALVVE 313
L R+ + TCA PE L + +S+P E F+C+ P +IT+ A+V
Sbjct: 451 LPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMV-- 508
Query: 314 GQAVSLRCRAV--------------------GDPEPVVHWVAPDGRLLGNSSRTRVRGDG 353
G+ + C A D E VH A DG ++ ++ +R
Sbjct: 509 GKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQ-- 566
Query: 354 TLDVTITTLRDSGTFTCIASNAAG 377
T G + C+ +N G
Sbjct: 567 ------VTFGHEGRYQCVITNHFG 584
Score = 49.3 bits (116), Expect = 1e-05
Identities = 61/274 (22%), Positives = 98/274 (35%), Gaps = 62/274 (22%)
Query: 15 PAALPFLLLLW----------AGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAID 64
P P LLLLW A A PC C C + + C GL +P +
Sbjct: 12 PRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDS----LDCGGRGLAALPGDLP 67
Query: 65 RRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNR 124
L L+ N ++ + F ++ +L + L+ N + V + A + +L L N+
Sbjct: 68 SWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVV-SLFLQHNK 126
Query: 125 LAEVRGDQLRG----------LGNL--------------RHLILGNNQIRRVESAAFDAF 160
+ V G QL+ L N+ + L L N+I +E AFD
Sbjct: 127 IRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGL 186
Query: 161 -----------------------LSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNL 197
L + LDL+ N + + + +L L L N
Sbjct: 187 SRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNN 246
Query: 198 IDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLF 231
I + +G F L K+ L + N L ++ L+
Sbjct: 247 ISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLY 280
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/81 (33%), Positives = 42/81 (51%), Gaps = 2/81 (2%)
Query: 310 LVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTL-RDSGTF 368
+V G+ V+L+C+A G+P P + W D R L + R + D L V + D+G +
Sbjct: 703 VVSVGETVALQCKATGNPPPRITWFKGD-RPLSLTERHHLTPDNQLLVVQNVVAEDAGRY 761
Query: 369 TCIASNAAGEATAPVEVCVVP 389
TC SN G A ++ V+P
Sbjct: 762 TCEMSNTLGTERAHSQLSVLP 782
Score = 41.2 bits (95), Expect = 0.004
Identities = 22/81 (27%), Positives = 35/81 (43%), Gaps = 3/81 (3%)
Query: 319 LRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVR---GDGTLDVTITTLRDSGTFTCIASNA 375
L C A G P P + W G + R+ D +T + D+G ++C A N+
Sbjct: 618 LECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNS 677
Query: 376 AGEATAPVEVCVVPLPLMAPP 396
AG +A + V+ P + P
Sbjct: 678 AGSISANATLTVLETPSLVVP 698
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 114 bits (285), Expect = 3e-25
Identities = 126/536 (23%), Positives = 204/536 (38%), Gaps = 121/536 (22%)
Query: 66 RVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRL 125
+++ + L +N + + + + +++L L ++ N + ++ GAF L L LHL+SNRL
Sbjct: 117 QLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRL 176
Query: 126 AEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAF-----------------------LS 162
+ L NL L++G N I R++ F L
Sbjct: 177 QMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLE 236
Query: 163 TVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQ-------------- 208
+E + N L +P A+ ++VNL L L+ N I+ I G F
Sbjct: 237 NLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPE 296
Query: 209 -----------LHKLVRLDMTSN-RLHKLPPDGLF---------LRSQ-------GTGPK 240
L L +++ T+N RL + P+ F L S GT
Sbjct: 297 LISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIES 356
Query: 241 PPTPLTVSFGGNPLHCNCELLWLR------RLTREDDLETCATPE----HLTDRYFWSIP 290
P +S NP+ C+C + W+ R D L PE ++ +F +
Sbjct: 357 LPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMM 416
Query: 291 EEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDG-RLLGN--SSRT 347
E +C P + V G VS CRA +P+P ++W+ P G +LL N + +
Sbjct: 417 E---ICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKF 473
Query: 348 RVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPG 407
V +GTLD+ T ++ G +TCIA+N G V + V
Sbjct: 474 YVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKV-------------------- 513
Query: 408 SSDIATPGRPGANDSAAERRLVAAELTSNSVLIRWPAQRPVPGIRMYQVQY----NSSVD 463
D + P D+ + ++ +NSVL+ W A + + + NS
Sbjct: 514 --DGSFP-----QDNNGSLNIKIRDIQANSVLVSWKASSKILKSSVKWTAFVKTENSHAA 566
Query: 464 DSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAG 519
S IPS + + + L Y +C+ D T R CV TT G
Sbjct: 567 QS---ARIPSDVKVYNLTHLNPSTEYKICI-----DIPTIYQKNR-KKCVNVTTKG 613
Score = 54.7 bits (130), Expect = 3e-07
Identities = 55/208 (26%), Positives = 87/208 (41%), Gaps = 15/208 (7%)
Query: 34 CPGRCICQNVAPTLT----------MLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVR-R 82
CP C C+ + P T + C GLL P + L L N IA +
Sbjct: 29 CPRLCTCE-IRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYS 87
Query: 83 RDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHL 142
DF +L L LS+N + V + L +++L+ N+L E+ L L NL+ L
Sbjct: 88 TDFP--VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 143 ILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIA 202
+ +N + + AF L + L L+ N L+ + + + NL L + N I I
Sbjct: 146 YINHNLLSTISPGAFIG-LHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIK 204
Query: 203 EGTFVQLHKLVRLDMTSNRLHKLPPDGL 230
+ F L L L + L ++P + L
Sbjct: 205 DMNFKPLINLRSLVIAGINLTEIPDNAL 232
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 114 bits (285), Expect = 3e-25
Identities = 126/536 (23%), Positives = 204/536 (38%), Gaps = 121/536 (22%)
Query: 66 RVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRL 125
+++ + L +N + + + + +++L L ++ N + ++ GAF L L LHL+SNRL
Sbjct: 117 QLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRL 176
Query: 126 AEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAF-----------------------LS 162
+ L NL L++G N I R++ F L
Sbjct: 177 QMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLE 236
Query: 163 TVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQ-------------- 208
+E + N L +P A+ ++VNL L L+ N I+ I G F
Sbjct: 237 NLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPE 296
Query: 209 -----------LHKLVRLDMTSN-RLHKLPPDGLF---------LRSQ-------GTGPK 240
L L +++ T+N RL + P+ F L S GT
Sbjct: 297 LISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIES 356
Query: 241 PPTPLTVSFGGNPLHCNCELLWLR------RLTREDDLETCATPE----HLTDRYFWSIP 290
P +S NP+ C+C + W+ R D L PE ++ +F +
Sbjct: 357 LPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMM 416
Query: 291 EEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDG-RLLGN--SSRT 347
E +C P + V G VS CRA +P+P ++W+ P G +LL N + +
Sbjct: 417 E---ICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKF 473
Query: 348 RVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPG 407
V +GTLD+ T ++ G +TCIA+N G V + V
Sbjct: 474 YVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKV-------------------- 513
Query: 408 SSDIATPGRPGANDSAAERRLVAAELTSNSVLIRWPAQRPVPGIRMYQVQY----NSSVD 463
D + P D+ + ++ +NSVL+ W A + + + NS
Sbjct: 514 --DGSFP-----QDNNGSLNIKIRDIQANSVLVSWKASSKILKSSVKWTAFVKTENSHAA 566
Query: 464 DSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAG 519
S IPS + + + L Y +C+ D T R CV TT G
Sbjct: 567 QS---ARIPSDVKVYNLTHLNPSTEYKICI-----DIPTIYQKNR-KKCVNVTTKG 613
Score = 54.7 bits (130), Expect = 3e-07
Identities = 55/208 (26%), Positives = 87/208 (41%), Gaps = 15/208 (7%)
Query: 34 CPGRCICQNVAPTLT----------MLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVR-R 82
CP C C+ + P T + C GLL P + L L N IA +
Sbjct: 29 CPRLCTCE-IRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYS 87
Query: 83 RDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHL 142
DF +L L LS+N + V + L +++L+ N+L E+ L L NL+ L
Sbjct: 88 TDFP--VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 143 ILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIA 202
+ +N + + AF L + L L+ N L+ + + + NL L + N I I
Sbjct: 146 YINHNLLSTISPGAFIG-LHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIK 204
Query: 203 EGTFVQLHKLVRLDMTSNRLHKLPPDGL 230
+ F L L L + L ++P + L
Sbjct: 205 DMNFKPLINLRSLVIAGINLTEIPDNAL 232
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 114 bits (285), Expect = 3e-25
Identities = 126/536 (23%), Positives = 204/536 (38%), Gaps = 121/536 (22%)
Query: 66 RVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRL 125
+++ + L +N + + + + +++L L ++ N + ++ GAF L L LHL+SNRL
Sbjct: 117 QLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRL 176
Query: 126 AEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAF-----------------------LS 162
+ L NL L++G N I R++ F L
Sbjct: 177 QMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLE 236
Query: 163 TVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQ-------------- 208
+E + N L +P A+ ++VNL L L+ N I+ I G F
Sbjct: 237 NLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPE 296
Query: 209 -----------LHKLVRLDMTSN-RLHKLPPDGLF---------LRSQ-------GTGPK 240
L L +++ T+N RL + P+ F L S GT
Sbjct: 297 LISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIES 356
Query: 241 PPTPLTVSFGGNPLHCNCELLWLR------RLTREDDLETCATPE----HLTDRYFWSIP 290
P +S NP+ C+C + W+ R D L PE ++ +F +
Sbjct: 357 LPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMM 416
Query: 291 EEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDG-RLLGN--SSRT 347
E +C P + V G VS CRA +P+P ++W+ P G +LL N + +
Sbjct: 417 E---ICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKF 473
Query: 348 RVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPG 407
V +GTLD+ T ++ G +TCIA+N G V + V
Sbjct: 474 YVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKV-------------------- 513
Query: 408 SSDIATPGRPGANDSAAERRLVAAELTSNSVLIRWPAQRPVPGIRMYQVQY----NSSVD 463
D + P D+ + ++ +NSVL+ W A + + + NS
Sbjct: 514 --DGSFP-----QDNNGSLNIKIRDIQANSVLVSWKASSKILKSSVKWTAFVKTENSHAA 566
Query: 464 DSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAG 519
S IPS + + + L Y +C+ D T R CV TT G
Sbjct: 567 QS---ARIPSDVKVYNLTHLNPSTEYKICI-----DIPTIYQKNR-KKCVNVTTKG 613
Score = 54.7 bits (130), Expect = 3e-07
Identities = 55/208 (26%), Positives = 87/208 (41%), Gaps = 15/208 (7%)
Query: 34 CPGRCICQNVAPTLT----------MLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVR-R 82
CP C C+ + P T + C GLL P + L L N IA +
Sbjct: 29 CPRLCTCE-IRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYS 87
Query: 83 RDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHL 142
DF +L L LS+N + V + L +++L+ N+L E+ L L NL+ L
Sbjct: 88 TDFP--VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 143 ILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIA 202
+ +N + + AF L + L L+ N L+ + + + NL L + N I I
Sbjct: 146 YINHNLLSTISPGAFIG-LHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIK 204
Query: 203 EGTFVQLHKLVRLDMTSNRLHKLPPDGL 230
+ F L L L + L ++P + L
Sbjct: 205 DMNFKPLINLRSLVIAGINLTEIPDNAL 232
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 105 bits (263), Expect = 1e-22
Identities = 92/302 (30%), Positives = 119/302 (39%), Gaps = 47/302 (15%)
Query: 1 MAPGPFSSALLSPPPAALPFLLLLWAGASR--GQPCPGRCICQNVAPTLTMLCAKTGLLF 58
+ PG SSA P LLLWA A R CP C C T+ C TGL
Sbjct: 3 LTPGWGSSA----GPVRPELWLLLWAAAWRLGASACPALCTCTGT----TVDCHGTGLQA 54
Query: 59 VPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRAL 118
+P I R L L N I + + DFA + L L L N IG V GAF D++ L L
Sbjct: 55 IPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERL 114
Query: 119 HLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALP 178
L+ N+ L L L+ NNQ + LDLS N ++A+P
Sbjct: 115 RLNRNQ-----------LHMLPELLFQNNQ--------------ALSRLDLSENAIQAIP 149
Query: 179 WEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTG 238
+A +L L LD N I I EG F L L L + +N + +P
Sbjct: 150 RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSF-------- 201
Query: 239 PKPPTPLTVSFGGNPLHCNCELLWLRRLTREDD----LETCATPEHLTDRYFWSIPEEEF 294
P T N L C+C L WL + R+ C+ P L + + EF
Sbjct: 202 NHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEF 261
Query: 295 LC 296
C
Sbjct: 262 SC 263
Score = 85.5 bits (210), Expect = 2e-16
Identities = 68/267 (25%), Positives = 105/267 (39%), Gaps = 65/267 (24%)
Query: 34 CPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLVH 93
CP C C N C GL +P + + E+RL
Sbjct: 282 CPAMCTCSNGIVD----CRGKGLTAIPANLPETMTEIRL--------------------- 316
Query: 94 LTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVE 153
N I + GAF+ R LR + L +N++AE+ D +GL +L L+L N+I +
Sbjct: 317 ---ELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLP 373
Query: 154 SAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLV 213
F L T++ L L+ N + + +A + NL+ L+L N I +A+GTF L +
Sbjct: 374 RGVFGG-LYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQ 432
Query: 214 RLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLE 273
L + NP C+C L WL R + +E
Sbjct: 433 TLHLAQ--------------------------------NPFICDCNLKWLADFLRTNPIE 460
Query: 274 T----CATPEHLTDRYFWSIPEEEFLC 296
T CA+P L ++ I ++F C
Sbjct: 461 TSGARCASPRRLANKRIGQIKSKKFRC 487
Score = 63.2 bits (152), Expect = 9e-10
Identities = 53/193 (27%), Positives = 84/193 (43%), Gaps = 39/193 (20%)
Query: 118 LHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEAL 177
L+LD N+ V G QL L+ + L NN+I + +++F +S + L LSYN L+ +
Sbjct: 766 LYLDGNQFTLVPG-QLSTFKYLQLVDLSNNKISSLSNSSFTN-MSQLTTLILSYNALQCI 823
Query: 178 PWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGT 237
P A + +L L+L N I + EG F + L L
Sbjct: 824 PPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHL---------------------- 861
Query: 238 GPKPPTPLTVSFGGNPLHCNCELLWLRRLT----REDDLETCATPEHLTDRYFWSIPEEE 293
+ G NPL+C+C L WL +E + CA P+ + + + P ++
Sbjct: 862 ----------AIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKK 911
Query: 294 FLCE-PPLITRQA 305
F C+ PP + QA
Sbjct: 912 FECQGPPTLAVQA 924
Score = 62.0 bits (149), Expect = 2e-09
Identities = 53/174 (30%), Positives = 74/174 (42%), Gaps = 33/174 (18%)
Query: 34 CPGRCICQ-NVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRD-FANMTSL 91
CP +C C+ NV C+ L +P I + ELRL +N I+ + F +T L
Sbjct: 513 CPHKCRCEANVVE-----CSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHL 567
Query: 92 VHLTLSRNTIGQVAAGAFAD------------------------LRALRALHLDSNRLAE 127
+ LS N + ++ GAF L LR L L +NR++
Sbjct: 568 KKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISC 627
Query: 128 VRGDQLRGLGNLRHLILGNNQIRRVESAAFDAF--LSTVEDLDLSYNNLEALPW 179
+ D GL N+R L L +NQI V AFD LST+ L +N L W
Sbjct: 628 IHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAW 681
Score = 47.0 bits (110), Expect = 7e-05
Identities = 42/176 (23%), Positives = 72/176 (40%), Gaps = 20/176 (11%)
Query: 142 LILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHI 201
L L NN+I +E+ L+ ++ ++LS N + + A +++ L L N ++ I
Sbjct: 545 LRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESI 604
Query: 202 AEGTFVQLHKLVRLDMTSNRLHKLPPDG----------------LFLRSQGTGPKPPTPL 245
G F L L L + +NR+ + D + S G +
Sbjct: 605 RSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLS 664
Query: 246 TVSFGGNPLHCNCELLWLRRLTREDDLET----CATPEHLTDRYFWSIPEEEFLCE 297
T++ NP +CNC+L WL R+ + T C P+ L + +F CE
Sbjct: 665 TLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCE 720
Score = 30.4 bits (67), Expect = 6.5
Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 3/63 (4%)
Query: 42 NVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTD---NFIAAVRRRDFANMTSLVHLTLSR 98
N++ T++ + L +PP + + LRL N I+ ++ FA++TSL HL +
Sbjct: 806 NMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGA 865
Query: 99 NTI 101
N +
Sbjct: 866 NPL 868
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 102 bits (253), Expect = 2e-21
Identities = 112/365 (30%), Positives = 145/365 (39%), Gaps = 48/365 (13%)
Query: 4 GPFSSALLSPPPAALPFLLLLWAGASR---GQPCPGRCICQNVAPTLTMLCAKTGLLFVP 60
GP SS + P LP L+LL +R Q CP CIC N + C L VP
Sbjct: 3 GPRSSTHV---PLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVA--CRYQNLTEVP 57
Query: 61 PAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHL 120
AI L L N + + F + L HL L + VA GAF L L L+L
Sbjct: 58 DAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNL 117
Query: 121 DSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWE 180
SN L E+ + L GLG+LR L L N + + F A L + L+L++N L LP
Sbjct: 118 ASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGA-LGALATLNLAHNALVYLPAM 176
Query: 181 AVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPK 240
A ++ + L L HN + +A L L RL + N L LP L SQ G
Sbjct: 177 AFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVL---SQARG-- 231
Query: 241 PPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTD-RYFWSIPEEEFLCEPP 299
+ G NPL E ED L E L D ++ F P
Sbjct: 232 ---LARLELGHNPLTYAGE---------EDGLALPGLRELLLDGGALQALGPRAFAHCPR 279
Query: 300 LITRQAGGRAL----VVEGQAVSLRCRAVGDP-------EPVVHWVAPDGRLLGNSSRTR 348
L T G L ++G R R G+P P++ W+A R R
Sbjct: 280 LHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCGCQARPLLEWLA----------RAR 329
Query: 349 VRGDG 353
VR DG
Sbjct: 330 VRSDG 334
Score = 75.9 bits (185), Expect = 1e-13
Identities = 89/312 (28%), Positives = 113/312 (36%), Gaps = 68/312 (21%)
Query: 33 PCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLV 92
PCP C+C V + C GL VP L L N +V R F + LV
Sbjct: 395 PCPRACVC--VPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLV 452
Query: 93 HLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRV 152
L L I ++ AGA A L L L+L N+LA + L G L +L L N+ +V
Sbjct: 453 SLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQV 512
Query: 153 ESAAFDAFLSTVE--------------DLD---------LSYNNLEALPWEAVGQMVNLN 189
AA A S DL LS N + + A+G L
Sbjct: 513 PGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELE 572
Query: 190 TLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKL-----PPDG-----LFLRS----- 234
L LD N + + G L L+ L ++ N L L P G LFL S
Sbjct: 573 KLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQ 632
Query: 235 ------QGTGP--------------KPPTPL-----TVSFGGNPLHCNCELLWLRRLTRE 269
G GP P P + NP HC+C+LL L R
Sbjct: 633 ICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTG 692
Query: 270 DDLE---TCATP 278
+L TCATP
Sbjct: 693 LNLRVGATCATP 704
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 99.8 bits (247), Expect = 9e-21
Identities = 98/390 (25%), Positives = 155/390 (39%), Gaps = 75/390 (19%)
Query: 66 RVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRL 125
++ L L +N I + ++++L L ++ N I ++A AFA L+ L LHL+SN+L
Sbjct: 120 QLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKL 179
Query: 126 AEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAF-----------------------LS 162
+ NL L++G N + + F L
Sbjct: 180 KVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLD 239
Query: 163 TVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQ-------------- 208
++E L N L +P A+ ++ NL L L+ N I I EG F
Sbjct: 240 SLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGE 299
Query: 209 -----------LHKLVRLDMTSNR----LHKLP------PDGLFLRS-------QGTGPK 240
L +L +L+ T+N +H+L + L L + Q T
Sbjct: 300 LVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVES 359
Query: 241 PPTPLTVSFGGNPLHCNCELLWLR-RLTREDDLET----CATPEHLTDRYFWS--IPEEE 293
P +S NPL C+C + W+ T +E CA P I +
Sbjct: 360 LPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSS 419
Query: 294 FLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLL---GNSSRTRVR 350
C P + R V G V L CRA+ +PEP ++WV P G + S + ++
Sbjct: 420 EQCLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLS 479
Query: 351 GDGTLDVTITTLRDSGTFTCIASNAAGEAT 380
+GTL+++ + DSG +TC+A N G T
Sbjct: 480 SEGTLEISNIQIEDSGRYTCVAQNVQGADT 509
Score = 60.8 bits (146), Expect = 4e-09
Identities = 53/206 (25%), Positives = 84/206 (40%), Gaps = 11/206 (5%)
Query: 34 CPGRCICQ---------NVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRD 84
CP C+C+ T+ C L +P + L L N IA +
Sbjct: 32 CPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVD-E 90
Query: 85 FANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLIL 144
+ +L L S+N + A+L L LHL+ N++ E+ L+ L NL+ L +
Sbjct: 91 LQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYI 150
Query: 145 GNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEG 204
+NQI + + AF A L + L L+ N L+ + NL L + N + I +
Sbjct: 151 NHNQISTISAHAF-AGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDM 209
Query: 205 TFVQLHKLVRLDMTSNRLHKLPPDGL 230
F L L L + L +P + L
Sbjct: 210 NFKPLANLRSLVLAGMYLTDIPGNAL 235
>gi|193083136 leucine-rich repeat, immunoglobulin-like and
transmembrane domains 3 [Homo sapiens]
Length = 634
Score = 99.4 bits (246), Expect = 1e-20
Identities = 84/301 (27%), Positives = 133/301 (44%), Gaps = 28/301 (9%)
Query: 118 LHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEAL 177
L ++ + + + L L++L + N + ++ ++F L + +L L N+L A
Sbjct: 17 LRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYN-LKQLHELRLDGNSLAAF 75
Query: 178 PWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRS--- 234
PW ++ M L TL L +N I + L L LD++SNRL LPPD FL S
Sbjct: 76 PWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPD--FLESWTH 133
Query: 235 -----QGTGPKPPTPLTVSFGGNPLHCNCELLWLRRLTRE--------DDLETCATPEHL 281
G P+ + + NP C+C + + L++ D L TC+ PE L
Sbjct: 134 LVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERL 193
Query: 282 TDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDG--- 338
T F E E +P ++T + + + G V LRC A G P P + W D
Sbjct: 194 TGILF-QRAELEHCLKPSVMT--SATKIMSALGSNVLLRCDATGFPTPQITWTRSDSSPV 250
Query: 339 --RLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPP 396
++ S VR + +T + +D+G + C A N AG + A V V V+ + P
Sbjct: 251 NYTVIQESPEEGVRW-SIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIP 309
Query: 397 P 397
P
Sbjct: 310 P 310
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 98.2 bits (243), Expect = 3e-20
Identities = 85/293 (29%), Positives = 120/293 (40%), Gaps = 74/293 (25%)
Query: 9 ALLSPPPAALP--------FLLLLWA---------------GASRGQPCPGRCICQ--NV 43
ALL PPP A P LLL W G + G CP C+C +
Sbjct: 31 ALLGPPPQASPPAGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDD 90
Query: 44 APTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSL------------ 91
A L++ C+ L +P + L L N +++V F N++SL
Sbjct: 91 ADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS 150
Query: 92 ------------VHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGD-------- 131
HL L RN + +A G FA AL +L L +NRL+ +
Sbjct: 151 LEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSL 210
Query: 132 ----------------QLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLE 175
RGLG+LR L+L N++ ++ A F L+ + +LDLS N L
Sbjct: 211 WDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSG-LAELRELDLSRNALR 269
Query: 176 ALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPD 228
A+ Q+ L L LD NLI +A G F+ L L LD++ NR+ L D
Sbjct: 270 AIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLED 322
Score = 89.7 bits (221), Expect = 9e-18
Identities = 61/181 (33%), Positives = 91/181 (50%), Gaps = 4/181 (2%)
Query: 49 MLCAKTGLLFVPPAIDRRVVELR---LTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVA 105
++ A L ++ PA+ + ELR L+ N + A++ F + L L L RN I VA
Sbjct: 237 LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVA 296
Query: 106 AGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVE 165
GAF L+ALR L L NR+A + D GL LR L L +N I + F L +E
Sbjct: 297 PGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKD-LHFLE 355
Query: 166 DLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKL 225
+L L +N + L + + L LTLDHN + + G F+ L + ++++ N L L
Sbjct: 356 ELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNL 415
Query: 226 P 226
P
Sbjct: 416 P 416
Score = 72.8 bits (177), Expect = 1e-12
Identities = 77/270 (28%), Positives = 109/270 (40%), Gaps = 46/270 (17%)
Query: 69 ELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLR--------------- 113
EL+L N I + R F + L LTL N + +V AGAF L
Sbjct: 356 ELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNL 415
Query: 114 ---------ALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTV 164
L +LHL+ + L +R GL LR L L +N + +E + L+ +
Sbjct: 416 PEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWG-LAEL 474
Query: 165 EDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHK 224
+LDL+ N L LP + L L L N + + L + LD++ NRL
Sbjct: 475 LELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEA 534
Query: 225 LP-----PDG----LFLRSQGT---GPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDL 272
LP P G L LR+ P+PP + GNP C C L LR ++
Sbjct: 535 LPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQN-- 592
Query: 273 ETCATPEHLTDRYFWSIPEEEFLCEPPLIT 302
A P R+ +I E + C+PP T
Sbjct: 593 -PSAVP-----RFVQAICEGDD-CQPPAYT 615
Score = 69.3 bits (168), Expect = 1e-11
Identities = 53/157 (33%), Positives = 76/157 (48%), Gaps = 1/157 (0%)
Query: 70 LRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVR 129
LRL+ N IA++R R F ++ L L L N I Q+A +F L L L LD N+L EV+
Sbjct: 333 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 392
Query: 130 GDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLN 189
GL N+ + L N +R + F L + L L + L + + L
Sbjct: 393 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRG-LGKLHSLHLEGSCLGRIRPHTFTGLSGLR 451
Query: 190 TLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLP 226
L L N + I E + L +L+ LD+TSN+L LP
Sbjct: 452 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLP 488
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/84 (35%), Positives = 44/84 (52%)
Query: 67 VVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLA 126
++EL LT N + + R F + L +L LSRN + ++ A A L+ L + NRL
Sbjct: 474 LLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLE 533
Query: 127 EVRGDQLRGLGNLRHLILGNNQIR 150
+ L LG LR+L L NN +R
Sbjct: 534 ALPNSLLAPLGRLRYLSLRNNSLR 557
>gi|62988340 leucine rich repeat containing 22 [Homo sapiens]
Length = 550
Score = 96.7 bits (239), Expect = 7e-20
Identities = 121/533 (22%), Positives = 193/533 (36%), Gaps = 83/533 (15%)
Query: 21 LLLLWAGASRGQP-CPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAA 79
L+L++ QP C C C + T+ C L +P + ++R+ ++ +
Sbjct: 10 LVLVFLDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFE 69
Query: 80 VRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNL 139
+ + F NM++L +L L+ N I + GA L LR L L+ N+L V R L
Sbjct: 70 MPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLL 129
Query: 140 RHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLID 199
R LDL N ++ALP A+ +V+L L L N +
Sbjct: 130 R-------------------------VLDLKRNKIDALPELALQFLVSLTYLDLSSNRLT 164
Query: 200 HIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGGNPLHCNCE 259
+++ F+ P R G + + L V+ NP C+C
Sbjct: 165 VVSKSVFLNW-----------------PAYQKCRQPDCGAEILSSLVVALHDNPWVCDCR 207
Query: 260 LLWLRRLTREDDLET--------CATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALV 311
L L + + L C P + F E C P I+ + +
Sbjct: 208 LRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHE--TELSACMKPQISTPS-ANITI 264
Query: 312 VEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGT----LDVTITTLRDSGT 367
GQ V+LRC A P P + W P T G+ T L + L DSG
Sbjct: 265 RAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSELAIPAAHLVDSGN 324
Query: 368 FTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGANDSAAERR 427
+TC+ASN+ G++ + + V P + P + P ++ A
Sbjct: 325 YTCMASNSIGKSNLVISLHVQPAQALHAPDSLSIP-----------------SEGNAYID 367
Query: 428 LVAAELTSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFLVNDLAAGR 487
L + T + +L+ W A + + S I T+ V+DL G
Sbjct: 368 LRVVKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEVVHIGPGINTYAVDDLLPGT 427
Query: 488 AYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAI 540
Y+ C+ +G CV F T D A R H L T+++ +
Sbjct: 428 KYEACLSL---EGQPPHQGQ----CVAFVTGRD-AGGLEAREHLLHVTVVLCV 472
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 96.7 bits (239), Expect = 7e-20
Identities = 64/222 (28%), Positives = 108/222 (48%), Gaps = 12/222 (5%)
Query: 13 PPPAALP---FLLLL-----WAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAID 64
P A+P +LLLL W CP C C + + C ++ VP +
Sbjct: 2 PLDKAMPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQ---VECTGARIVAVPTPLP 58
Query: 65 RRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNR 124
+ L++ + I + F N+++L+ L + +N + ++ GAF +L +LR L L +N+
Sbjct: 59 WNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNK 118
Query: 125 LAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQ 184
L + +GL +L L+L +NQ+ +++ A F S +++L L N+LE +P A
Sbjct: 119 LQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQ-CSNLKELQLHGNHLEYIPDGAFDH 177
Query: 185 MVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLP 226
+V L L L N + HI+ F L L L + NRL +P
Sbjct: 178 LVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIP 219
Score = 67.8 bits (164), Expect = 4e-11
Identities = 43/157 (27%), Positives = 78/157 (49%), Gaps = 1/157 (0%)
Query: 70 LRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVR 129
L L++N I+ + F + L LTL N++ +++ G F + LR L L N ++ +
Sbjct: 256 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 315
Query: 130 GDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLN 189
+ L L+ LIL NQI + AF+ L+ + +L L N L+ L + NL
Sbjct: 316 DNVFSNLRQLQVLILSRNQISFISPGAFNG-LTELRELSLHTNALQDLDGNVFRMLANLQ 374
Query: 190 TLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLP 226
++L +N + + F ++ L+ + + +N+L LP
Sbjct: 375 NISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP 411
Score = 66.2 bits (160), Expect = 1e-10
Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 1/128 (0%)
Query: 69 ELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEV 128
EL L DN I+++ F+N+ L L LSRN I ++ GAF L LR L L +N L ++
Sbjct: 303 ELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 362
Query: 129 RGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNL 188
G+ R L NL+++ L NN++R++ F A ++ + + L N LE LP + L
Sbjct: 363 DGNVFRMLANLQNISLQNNRLRQLPGNIF-ANVNGLMAIQLQNNQLENLPLGIFDHLGKL 421
Query: 189 NTLTLDHN 196
L L N
Sbjct: 422 CELRLYDN 429
Score = 65.1 bits (157), Expect = 2e-10
Identities = 54/187 (28%), Positives = 87/187 (46%), Gaps = 5/187 (2%)
Query: 48 TMLCAKTGLLFVPPAIDRR---VVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQV 104
++L + LL + PA + + EL+L N + + F ++ L L L +N++ +
Sbjct: 135 SLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHI 194
Query: 105 AAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTV 164
+ F L L+ L L NRL ++ GL NL+ L L NQI + F +
Sbjct: 195 SPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN-NHNL 253
Query: 165 EDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHK 224
+ L LS N++ LP Q+ LN LTL N + ++ G F + L L + N +
Sbjct: 254 QRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISS 313
Query: 225 LPPDGLF 231
L PD +F
Sbjct: 314 L-PDNVF 319
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 96.3 bits (238), Expect = 1e-19
Identities = 61/212 (28%), Positives = 104/212 (49%), Gaps = 9/212 (4%)
Query: 20 FLLLL-----WAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTD 74
+LLLL W CP C C + + C ++ VP + + L++ +
Sbjct: 6 YLLLLVGCQAWGAGLAYHGCPSECTCSRASQ---VECTGARIVAVPTPLPWNAMSLQILN 62
Query: 75 NFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLR 134
I + F N+++L+ L + +N + ++ GAF +L +LR L L +N+L + +
Sbjct: 63 THITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQ 122
Query: 135 GLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLD 194
GL +L L+L +NQ+ +++ A F S +++L L N+LE +P A +V L L L
Sbjct: 123 GLDSLESLLLSSNQLLQIQPAHFSQ-CSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLG 181
Query: 195 HNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLP 226
N + HI+ F L L L + NRL +P
Sbjct: 182 KNSLTHISPRVFQHLGNLQVLRLYENRLTDIP 213
Score = 67.8 bits (164), Expect = 4e-11
Identities = 43/157 (27%), Positives = 78/157 (49%), Gaps = 1/157 (0%)
Query: 70 LRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVR 129
L L++N I+ + F + L LTL N++ +++ G F + LR L L N ++ +
Sbjct: 250 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 309
Query: 130 GDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLN 189
+ L L+ LIL NQI + AF+ L+ + +L L N L+ L + NL
Sbjct: 310 DNVFSNLRQLQVLILSRNQISFISPGAFNG-LTELRELSLHTNALQDLDGNVFRMLANLQ 368
Query: 190 TLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLP 226
++L +N + + F ++ L+ + + +N+L LP
Sbjct: 369 NISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP 405
Score = 66.2 bits (160), Expect = 1e-10
Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 1/128 (0%)
Query: 69 ELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEV 128
EL L DN I+++ F+N+ L L LSRN I ++ GAF L LR L L +N L ++
Sbjct: 297 ELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 356
Query: 129 RGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNL 188
G+ R L NL+++ L NN++R++ F A ++ + + L N LE LP + L
Sbjct: 357 DGNVFRMLANLQNISLQNNRLRQLPGNIF-ANVNGLMAIQLQNNQLENLPLGIFDHLGKL 415
Query: 189 NTLTLDHN 196
L L N
Sbjct: 416 CELRLYDN 423
Score = 65.1 bits (157), Expect = 2e-10
Identities = 54/187 (28%), Positives = 87/187 (46%), Gaps = 5/187 (2%)
Query: 48 TMLCAKTGLLFVPPAIDRR---VVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQV 104
++L + LL + PA + + EL+L N + + F ++ L L L +N++ +
Sbjct: 129 SLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHI 188
Query: 105 AAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTV 164
+ F L L+ L L NRL ++ GL NL+ L L NQI + F +
Sbjct: 189 SPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN-NHNL 247
Query: 165 EDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHK 224
+ L LS N++ LP Q+ LN LTL N + ++ G F + L L + N +
Sbjct: 248 QRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISS 307
Query: 225 LPPDGLF 231
L PD +F
Sbjct: 308 L-PDNVF 313
>gi|88702793 slit-like 2 [Homo sapiens]
Length = 673
Score = 96.3 bits (238), Expect = 1e-19
Identities = 76/238 (31%), Positives = 109/238 (45%), Gaps = 25/238 (10%)
Query: 10 LLSPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVE 69
+ S P LP LLLL G Q CP C C T+ C VP + V
Sbjct: 1 MCSRVPLLLPLLLLLALGPGV-QGCPSGCQCSQPQ---TVFCTARQGTTVPRDVPPDTVG 56
Query: 70 LRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVR 129
L + +N I + FA + L L LS+N I + +G F L L L L +NRL E+
Sbjct: 57 LYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEIT 116
Query: 130 GDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNL- 188
+ RGL L L LG N+IR ++ AFD L + +L L N L ALP + +++ L
Sbjct: 117 NETFRGLRRLERLYLGKNRIRHIQPGAFDT-LDRLLELKLQDNELRALPPLRLPRLLLLD 175
Query: 189 ----NTLTLDHNLID---------------HIAEGTFVQLHKLVRLDMTSNRLHKLPP 227
+ L L+ ++D + EG F +L L LD++ N+L ++PP
Sbjct: 176 LSHNSLLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPP 233
Score = 43.5 bits (101), Expect = 7e-04
Identities = 46/144 (31%), Positives = 72/144 (50%), Gaps = 14/144 (9%)
Query: 59 VPPAIDRRVVELRLTDNFIAAVRRR--DFANMTSLVHLTLSRNTIGQVAAGAFADLRALR 116
+PP R++ L L+ N + A+ D AN+ +L L+ + Q+ G F+ LR L
Sbjct: 163 LPPLRLPRLLLLDLSHNSLLALEPGILDTANVEAL---RLAGLGLQQLDEGLFSRLRNLH 219
Query: 117 ALHLDSNRLAEV----RGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYN 172
L + N+L V RG LRGL LR + GN +I ++ A L+ +++LD+S
Sbjct: 220 DLDVSDNQLERVPPVIRG--LRGLTRLR--LAGNTRIAQLRPEDL-AGLAALQELDVSNL 274
Query: 173 NLEALPWEAVGQMVNLNTLTLDHN 196
+L+ALP + G L L N
Sbjct: 275 SLQALPGDLSGLFPRLRLLAAARN 298
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,582,949
Number of Sequences: 37866
Number of extensions: 1790923
Number of successful extensions: 16118
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 313
Number of HSP's successfully gapped in prelim test: 375
Number of HSP's that attempted gapping in prelim test: 11720
Number of HSP's gapped (non-prelim): 3098
length of query: 771
length of database: 18,247,518
effective HSP length: 110
effective length of query: 661
effective length of database: 14,082,258
effective search space: 9308372538
effective search space used: 9308372538
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.