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Search of human proteins with 149274653
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149274653 patched domain containing 2 [Homo sapiens]
(1392 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149274653 patched domain containing 2 [Homo sapiens] 2814 0.0
gi|25952134 dispatched A [Homo sapiens] 86 3e-16
gi|52145305 patched 2 [Homo sapiens] 68 7e-11
gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens] 64 1e-09
gi|25121980 dispatched B [Homo sapiens] 61 9e-09
gi|134254450 patched isoform S [Homo sapiens] 53 2e-06
gi|134254435 patched isoform S [Homo sapiens] 53 2e-06
gi|134254468 patched isoform S [Homo sapiens] 53 2e-06
gi|134254452 patched isoform S [Homo sapiens] 53 2e-06
gi|134254432 patched isoform L' [Homo sapiens] 53 2e-06
gi|134254466 patched isoform M [Homo sapiens] 53 2e-06
gi|134254446 patched isoform L [Homo sapiens] 53 2e-06
gi|194018513 patched domain containing 3 [Homo sapiens] 50 2e-05
gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapi... 49 3e-05
gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapi... 49 3e-05
gi|148612890 serine-arginine repressor protein [Homo sapiens] 36 0.29
gi|148277106 hypothetical protein LOC442213 [Homo sapiens] 36 0.29
gi|115298674 nidogen 1 precursor [Homo sapiens] 34 0.86
gi|116256471 SNF1-like kinase [Homo sapiens] 34 1.1
gi|170650672 Leber congenital amaurosis 5 [Homo sapiens] 33 1.5
gi|170650670 Leber congenital amaurosis 5 [Homo sapiens] 33 1.5
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 33 2.5
gi|169211642 PREDICTED: hypothetical protein [Homo sapiens] 32 3.3
gi|169210857 PREDICTED: similar to RIKEN cDNA E130309D14 [Homo s... 32 3.3
gi|92091572 dedicator of cytokinesis 4 [Homo sapiens] 32 3.3
gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo s... 32 3.3
gi|189011544 ubiquitously transcribed tetratricopeptide repeat, ... 32 4.3
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 32 4.3
gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens] 32 5.6
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 32 5.6
>gi|149274653 patched domain containing 2 [Homo sapiens]
Length = 1392
Score = 2814 bits (7294), Expect = 0.0
Identities = 1392/1392 (100%), Positives = 1392/1392 (100%)
Query: 1 MDTEDDPLLQDVWLEEEQEEEEATGETFLGAQKPGPQPGAGGQCCWRHWPLASRPPASGF 60
MDTEDDPLLQDVWLEEEQEEEEATGETFLGAQKPGPQPGAGGQCCWRHWPLASRPPASGF
Sbjct: 1 MDTEDDPLLQDVWLEEEQEEEEATGETFLGAQKPGPQPGAGGQCCWRHWPLASRPPASGF 60
Query: 61 WSTLGWAFTNPCCAGLVLFLGCSIPMALSAFMFLYYPPLDIDISYNAFEIRNHEASQRFD 120
WSTLGWAFTNPCCAGLVLFLGCSIPMALSAFMFLYYPPLDIDISYNAFEIRNHEASQRFD
Sbjct: 61 WSTLGWAFTNPCCAGLVLFLGCSIPMALSAFMFLYYPPLDIDISYNAFEIRNHEASQRFD 120
Query: 121 ALTLALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNRSRQASRAPRVIPAASL 180
ALTLALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNRSRQASRAPRVIPAASL
Sbjct: 121 ALTLALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNRSRQASRAPRVIPAASL 180
Query: 181 GGPGPYRDTSAAQKPTANRSGRLRRETPPLEDLAANQSEDPRNQRLSKNGRYQPSIPPHA 240
GGPGPYRDTSAAQKPTANRSGRLRRETPPLEDLAANQSEDPRNQRLSKNGRYQPSIPPHA
Sbjct: 181 GGPGPYRDTSAAQKPTANRSGRLRRETPPLEDLAANQSEDPRNQRLSKNGRYQPSIPPHA 240
Query: 241 AVAANQSRARRGASRWDYSRAYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHE 300
AVAANQSRARRGASRWDYSRAYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHE
Sbjct: 241 AVAANQSRARRGASRWDYSRAYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHE 300
Query: 301 IERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQD 360
IERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQD
Sbjct: 301 IERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQD 360
Query: 361 LADIRGSLELAMTHPEFYWYVDEGLSADNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRA 420
LADIRGSLELAMTHPEFYWYVDEGLSADNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRA
Sbjct: 361 LADIRGSLELAMTHPEFYWYVDEGLSADNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRA 420
Query: 421 KFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYIL 480
KFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYIL
Sbjct: 421 KFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYIL 480
Query: 481 TSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINT 540
TSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINT
Sbjct: 481 TSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINT 540
Query: 541 YRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSC 600
YRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSC
Sbjct: 541 YRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSC 600
Query: 601 CWLAVLVTMPAALGLWSLYLAPLESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQ 660
CWLAVLVTMPAALGLWSLYLAPLESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQ
Sbjct: 601 CWLAVLVTMPAALGLWSLYLAPLESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQ 660
Query: 661 GPIPYLDDDIPLLEVEEEPVSLELGDVSLVSVSPEGLQPASNTGSRGHLIVQLQELLHHW 720
GPIPYLDDDIPLLEVEEEPVSLELGDVSLVSVSPEGLQPASNTGSRGHLIVQLQELLHHW
Sbjct: 661 GPIPYLDDDIPLLEVEEEPVSLELGDVSLVSVSPEGLQPASNTGSRGHLIVQLQELLHHW 720
Query: 721 VLWSAVKSRWVIVGLFVSILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEG 780
VLWSAVKSRWVIVGLFVSILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEG
Sbjct: 721 VLWSAVKSRWVIVGLFVSILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEG 780
Query: 781 ISCITCSGLFQEKPHSLQNNIRTSLEKKRRGSGVPWASRPEATLQDFPGTVYISKVKSQG 840
ISCITCSGLFQEKPHSLQNNIRTSLEKKRRGSGVPWASRPEATLQDFPGTVYISKVKSQG
Sbjct: 781 ISCITCSGLFQEKPHSLQNNIRTSLEKKRRGSGVPWASRPEATLQDFPGTVYISKVKSQG 840
Query: 841 HPAVYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGNFTKKLTACMSTVGLLQAASPS 900
HPAVYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGNFTKKLTACMSTVGLLQAASPS
Sbjct: 841 HPAVYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGNFTKKLTACMSTVGLLQAASPS 900
Query: 901 RKWMLTTLACDAKRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRVCMAPPGCLLSS 960
RKWMLTTLACDAKRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRVCMAPPGCLLSS
Sbjct: 901 RKWMLTTLACDAKRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRVCMAPPGCLLSS 960
Query: 961 SPDGPTKGFFFVPSEKVPKARLSATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGV 1020
SPDGPTKGFFFVPSEKVPKARLSATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGV
Sbjct: 961 SPDGPTKGFFFVPSEKVPKARLSATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGV 1020
Query: 1021 NRTRQVDNHVIGDPGSVVYDSSFDLFKEIGHLCHLCKAIAANSELVKPGGAQCLPSGYSI 1080
NRTRQVDNHVIGDPGSVVYDSSFDLFKEIGHLCHLCKAIAANSELVKPGGAQCLPSGYSI
Sbjct: 1021 NRTRQVDNHVIGDPGSVVYDSSFDLFKEIGHLCHLCKAIAANSELVKPGGAQCLPSGYSI 1080
Query: 1081 SSFLQMLHPECKELPEPNLLPGQLSHGAVGVREGRVQWISMAFESTTYKGKSSFQTYSDY 1140
SSFLQMLHPECKELPEPNLLPGQLSHGAVGVREGRVQWISMAFESTTYKGKSSFQTYSDY
Sbjct: 1081 SSFLQMLHPECKELPEPNLLPGQLSHGAVGVREGRVQWISMAFESTTYKGKSSFQTYSDY 1140
Query: 1141 LRWESFLQQQLQALPEGSVLRRGFQTCEHWKQIFMEIVGVQSALCGLVLSLLICVAAVAV 1200
LRWESFLQQQLQALPEGSVLRRGFQTCEHWKQIFMEIVGVQSALCGLVLSLLICVAAVAV
Sbjct: 1141 LRWESFLQQQLQALPEGSVLRRGFQTCEHWKQIFMEIVGVQSALCGLVLSLLICVAAVAV 1200
Query: 1201 FTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYL 1260
FTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYL
Sbjct: 1201 FTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYL 1260
Query: 1261 LAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGK 1320
LAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGK
Sbjct: 1261 LAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGK 1320
Query: 1321 IVALNTGVSILYTLTVSTALLGIMAPSSFTRTRTSFLKALGAVLLAGALGLGACLVLLQS 1380
IVALNTGVSILYTLTVSTALLGIMAPSSFTRTRTSFLKALGAVLLAGALGLGACLVLLQS
Sbjct: 1321 IVALNTGVSILYTLTVSTALLGIMAPSSFTRTRTSFLKALGAVLLAGALGLGACLVLLQS 1380
Query: 1381 GYKIPLPAGASL 1392
GYKIPLPAGASL
Sbjct: 1381 GYKIPLPAGASL 1392
>gi|25952134 dispatched A [Homo sapiens]
Length = 1524
Score = 85.5 bits (210), Expect = 3e-16
Identities = 59/207 (28%), Positives = 96/207 (46%), Gaps = 22/207 (10%)
Query: 452 DYEVRRTFNNDMLLAFISSSCIAALVYILTSC----SVFLSFFGIASIGLSCLVALFLYH 507
++ ++ + D LL IA ++ +L C S+F++ + +I S +V+ FLY
Sbjct: 488 EFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYR 547
Query: 508 VVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTV----QTAGK 563
VVF ++ +N A ++VGIG DD FV + + T + P TV Q A
Sbjct: 548 VVFHFEFFPFMNLTALIILVGIGADDAFVLCDVWNY-TKFDKPHAETSETVSITLQHAAL 606
Query: 564 ATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSLYLAPL 623
+ F TS TTAAA+ AN S I A+ FG++ + ++ ++ +PA + L YL +
Sbjct: 607 SMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNI 666
Query: 624 -------------ESSCQTSCHQNCSR 637
SC T Q C +
Sbjct: 667 FTCFKKPQQQIYDNKSCWTVACQKCHK 693
Score = 69.3 bits (168), Expect = 2e-11
Identities = 50/214 (23%), Positives = 102/214 (47%), Gaps = 24/214 (11%)
Query: 1116 VQWISMAFESTTYKGKSSFQTYSDYLRWESFLQQQLQALPEGSVLRRGFQTCEHWKQIFM 1175
++ + + F+ST + + + Y +S++ +L + PEG L G W +
Sbjct: 920 IRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPEG--LSNG------WFVSNL 971
Query: 1176 EIVGVQSALC-----GLVLSLLICVAAVAVFTTHILLLLPVLLSILGIVCLVVTIMYWSG 1230
E +Q +L + LS+ + + + + T +I++ L ++SI G + + V + G
Sbjct: 972 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLG 1031
Query: 1231 WEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVG 1290
WE+ +E++++S+ VG SVD+ VH Y LA + R+ + + ++ VG
Sbjct: 1032 WELNVLESVTISVAVGLSVDFAVHYGVAYRLAPD-----------PDREGKVIFSLSRVG 1080
Query: 1291 VAIVSSALTTVIATVPLFFCIIAPFAKFGKIVAL 1324
A+ +ALTT +A + + + + G + L
Sbjct: 1081 SAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMML 1114
Score = 53.5 bits (127), Expect = 1e-06
Identities = 49/185 (26%), Positives = 87/185 (47%), Gaps = 6/185 (3%)
Query: 421 KFQSFVVTYVAMLAKQSTSKVQVLYGG---TDLFDYEVRRTFNNDMLLAFISSSCIAALV 477
K F + ++ + +S + L G ++L Y+++ + ++ L+A S +A V
Sbjct: 939 KMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSV 998
Query: 478 YILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVF 537
+LT+ ++ +S + I SI + V + V+ G + L +L V V VG+ VD +
Sbjct: 999 MLLTTWNIIISLYAIISIAGTIFVTVGSL-VLLGWE-LNVLESVTISVAVGLSVDFAVHY 1056
Query: 538 INTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLI 597
YR A D + ++I ++ G A +LTT A A + S + A G FM LI
Sbjct: 1057 GVAYRLAPD-PDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLI 1115
Query: 598 VSCCW 602
+ W
Sbjct: 1116 MCISW 1120
>gi|52145305 patched 2 [Homo sapiens]
Length = 1203
Score = 67.8 bits (164), Expect = 7e-11
Identities = 60/244 (24%), Positives = 104/244 (42%), Gaps = 20/244 (8%)
Query: 390 LKSSLLRSEILFGAPLP-------NYYSVDDRWEEQRAKF------QSFVVTYVAMLAKQ 436
L++ L+S L +P +Y + D W E++A + FV L +
Sbjct: 311 LRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPEN 370
Query: 437 STSKVQVLYGGTDLFDY-----EVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFG 491
++ ++ + T L D EV L ++ +C+ L + + G
Sbjct: 371 ASQQIHA-FSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDCAQSQGSVGLAG 429
Query: 492 IASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQ 551
+ + L+ L L + GI + V F+ +GIGVDDVF+ + + +A Q
Sbjct: 430 VLLVALAVASGLGLC-ALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQ 488
Query: 552 LRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPA 611
RM +Q G + TS+ AA+ IPA+ F L +++V C ++AV++ PA
Sbjct: 489 ERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPA 548
Query: 612 ALGL 615
L L
Sbjct: 549 ILSL 552
Score = 43.9 bits (102), Expect = 0.001
Identities = 42/166 (25%), Positives = 73/166 (43%), Gaps = 25/166 (15%)
Query: 1191 LLICVAAVAVFTTHILLLL-PVLLSILGIVCLVVT-----IMYWSGWEMGAVEAISLSIL 1244
L +C+ V F LLLL P ++ +V ++T IM + G ++ A+ + L
Sbjct: 966 LAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVAS 1025
Query: 1245 VGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIAT 1304
VG V++ VH+ G+L + R R A+ H + A++T++
Sbjct: 1026 VGIGVEFTVHVALGFL------------TTQGSRNLRAAHALEHTFAPVTDGAISTLLGL 1073
Query: 1305 VPL----FFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346
+ L F I+ F F + L T + +L+ L + LL I+ P
Sbjct: 1074 LMLAGSHFDFIVRYF--FAALTVL-TLLGLLHGLVLLPVLLSILGP 1116
>gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens]
Length = 1278
Score = 63.5 bits (153), Expect = 1e-09
Identities = 56/256 (21%), Positives = 110/256 (42%), Gaps = 25/256 (9%)
Query: 375 PEFYWYVDEGLSADNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLA 434
P F W V G N ++ + ++ P+ NYY+ D + QRA Q++ ++ +
Sbjct: 540 PVFPWLVLGGYDDQNYNNA---TALVITFPVNNYYN--DTEKLQRA--QAWEKEFINFVK 592
Query: 435 KQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYI-----------LTSC 483
+ + + + E+ R ++D+ IS + + + + L
Sbjct: 593 NYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDS 652
Query: 484 SVFLSFFGIASI--GLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTY 541
V L GI + ++C + +F Y G+ I+ V F+++ +GVD++F+ + Y
Sbjct: 653 KVSLGIAGILIVLSSVACSLGVFSY---IGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY 709
Query: 542 RQATHLEDPQL--RMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVS 599
++ L+ L ++ + + F +S + A+ S +PAVH F LF L V
Sbjct: 710 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF 769
Query: 600 CCWLAVLVTMPAALGL 615
+L + + LGL
Sbjct: 770 IDFLLQITCFVSLLGL 785
Score = 33.5 bits (75), Expect = 1.5
Identities = 30/131 (22%), Positives = 58/131 (44%), Gaps = 25/131 (19%)
Query: 1195 VAAVAVFTTHILLLLPVLLSILGIVCLVVT--------IMYWSGWEMGAVEAISLSILVG 1246
V+ A+F ++LL L S + I+C + +M+ G + AV ++L + G
Sbjct: 1104 VSLGAIFLVTMVLLGCELWSAV-IMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCG 1162
Query: 1247 SSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVP 1306
SV++C H+ + ++ + +AE EA+ H+G ++ S T +
Sbjct: 1163 ISVEFCSHITRAFTVSMKGSRVERAE-----------EALAHMGSSVFSGITLTKFGGI- 1210
Query: 1307 LFFCIIAPFAK 1317
++ FAK
Sbjct: 1211 ----VVLAFAK 1217
>gi|25121980 dispatched B [Homo sapiens]
Length = 1401
Score = 60.8 bits (146), Expect = 9e-09
Identities = 44/141 (31%), Positives = 69/141 (48%), Gaps = 3/141 (2%)
Query: 484 SVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQ 543
S+FL+ + + S LVA FLY V F + Y +N A ++ + + +F + +R
Sbjct: 509 SLFLTLMVLLGVLGSLLVAFFLYQVAFRMAYFPFVNLAALLLLSSVCANHTLIFFDLWRL 568
Query: 544 A-THLEDPQL--RMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSC 600
+ + L L R+ T+ G + LTT+AA+ A+ S++PAV LFM V
Sbjct: 569 SKSQLPSGGLAQRVGRTMHHFGYLLLVSGLTTSAAFYASYLSRLPAVRCLALFMGTAVLV 628
Query: 601 CWLAVLVTMPAALGLWSLYLA 621
LV +PA+ L YLA
Sbjct: 629 HLALTLVWLPASAVLHERYLA 649
Score = 50.4 bits (119), Expect = 1e-05
Identities = 54/221 (24%), Positives = 90/221 (40%), Gaps = 29/221 (13%)
Query: 1114 GRVQWISMAFESTTYKGKSSFQTYSDYLRWESFLQQQLQALPEGSVLRRGFQTCEHWKQI 1173
G + + + F++ QT Y +L +L P G LRRG+ T
Sbjct: 898 GSLAALVLQFQTNFRNSPDYNQTQLFYNEVSHWLAAELGMAPPG--LRRGWFTSR----- 950
Query: 1174 FMEIVGVQSALCG-----LVLSLLICVAAVAVFTTHILLLLPVLLSILGIVCLVVTIMYW 1228
+E+ +Q +L L L+L + A + + T ++ L L + ++ G V L V ++
Sbjct: 951 -LELYSLQHSLSTEPAVVLGLALALAFATLLLGTWNVPLSLFSVAAVAGTVLLTVGLLVL 1009
Query: 1229 SGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRH 1288
W++ EA+ LS VG SVD+ V+ Y +L PH +R R
Sbjct: 1010 LEWQLNTAEALFLSASVGLSVDFTVNYCISY-----HLCPHPDRLSRVAFSLRQTSCATA 1064
Query: 1289 VGVAIVSSALTTVIATVPLFF-----------CIIAPFAKF 1318
VG A + +A ++ L + C+ FA F
Sbjct: 1065 VGAAALFAAGVLMLPATVLLYRKLGIILMMVKCVSCGFASF 1105
Score = 32.3 bits (72), Expect = 3.3
Identities = 40/157 (25%), Positives = 72/157 (45%), Gaps = 15/157 (9%)
Query: 1188 VLSLLICVAAVAVFTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISL-SILVG 1246
+L+L+ +A++ + L L VLL +LG + LV +Y + M ++L ++L+
Sbjct: 493 LLALVAIFFGMALYLRSLFLTLMVLLGVLGSL-LVAFFLYQVAFRMAYFPFVNLAALLLL 551
Query: 1247 SSV--DYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIAT 1304
SSV ++ + + + L+ LP QR RT+ H G ++ S LTT A
Sbjct: 552 SSVCANHTLIFFDLWRLSKSQLP----SGGLAQRVGRTM---HHFGYLLLVSGLTTSAA- 603
Query: 1305 VPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALL 1341
F+ + +AL G ++L L ++ L
Sbjct: 604 ---FYASYLSRLPAVRCLALFMGTAVLVHLALTLVWL 637
>gi|134254450 patched isoform S [Homo sapiens]
Length = 1296
Score = 53.1 bits (126), Expect = 2e-06
Identities = 87/394 (22%), Positives = 152/394 (38%), Gaps = 65/394 (16%)
Query: 415 WEEQRAK--FQSFVVTYVAML----AKQSTSKVQVLYGGT------DLFDYEVRRTFNND 462
W E +A +++ TYV ++ A+ ST KV T D V R +
Sbjct: 236 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGY 295
Query: 463 MLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVA 522
+L+ ++ +C+ L + + + G+ + LS L L ++ GI + V
Sbjct: 296 LLM--LAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLI-GISFNAATTQVL 352
Query: 523 AFVIVGIGVDDVFVFINTYRQATH-----LEDPQLRMIHTVQTAGKATFFTSLTTAAAYA 577
F+ +G+GVDDVF+ + + + ED R ++ G + TS++ A+
Sbjct: 353 PFLALGVGVDDVFLLAHAFSETGQNKRIPFED---RTGECLKRTGASVALTSISNVTAFF 409
Query: 578 ANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL------------WSLYLAP--- 622
IPA+ F L +++V + VL+ PA L + + + +P
Sbjct: 410 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVS 469
Query: 623 ----LESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEE 678
+E T H N + FA Q+ D + E
Sbjct: 470 RVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAE 529
Query: 679 PVSLELGDVSLVSVSPEGL--QPASNTGSRGHLIVQLQELLHH--------WVLWSAV-- 726
P S E+ V V+V+ + L Q +T S L+ Q + H W L S
Sbjct: 530 PRS-EIS-VQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEK 587
Query: 727 ---------KSRWVIVGLFVSILILSLVFASRLR 751
K++ V++ LF+ +L +SL +R+R
Sbjct: 588 HYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVR 621
Score = 32.3 bits (72), Expect = 3.3
Identities = 35/167 (20%), Positives = 67/167 (40%), Gaps = 39/167 (23%)
Query: 1205 ILLLLPVLLSILGIVCLVVTIMYWS----------------------GWEMGAVEAISLS 1242
+LL + V+L+ +VC V + W+ G ++ AV + L
Sbjct: 877 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 936
Query: 1243 ILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVI 1302
VG V++ VH+ +L A + R + A+ H+ ++ A++T++
Sbjct: 937 ASVGIGVEFTVHVALAFL------------TAIGDKNRRAVLALEHMFAPVLDGAVSTLL 984
Query: 1303 ATVPLF---FCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346
+ L F I + F ++A+ T + +L L + LL P
Sbjct: 985 GVLMLAGSEFDFIVRY--FFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
>gi|134254435 patched isoform S [Homo sapiens]
Length = 1296
Score = 53.1 bits (126), Expect = 2e-06
Identities = 87/394 (22%), Positives = 152/394 (38%), Gaps = 65/394 (16%)
Query: 415 WEEQRAK--FQSFVVTYVAML----AKQSTSKVQVLYGGT------DLFDYEVRRTFNND 462
W E +A +++ TYV ++ A+ ST KV T D V R +
Sbjct: 236 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGY 295
Query: 463 MLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVA 522
+L+ ++ +C+ L + + + G+ + LS L L ++ GI + V
Sbjct: 296 LLM--LAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLI-GISFNAATTQVL 352
Query: 523 AFVIVGIGVDDVFVFINTYRQATH-----LEDPQLRMIHTVQTAGKATFFTSLTTAAAYA 577
F+ +G+GVDDVF+ + + + ED R ++ G + TS++ A+
Sbjct: 353 PFLALGVGVDDVFLLAHAFSETGQNKRIPFED---RTGECLKRTGASVALTSISNVTAFF 409
Query: 578 ANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL------------WSLYLAP--- 622
IPA+ F L +++V + VL+ PA L + + + +P
Sbjct: 410 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVS 469
Query: 623 ----LESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEE 678
+E T H N + FA Q+ D + E
Sbjct: 470 RVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAE 529
Query: 679 PVSLELGDVSLVSVSPEGL--QPASNTGSRGHLIVQLQELLHH--------WVLWSAV-- 726
P S E+ V V+V+ + L Q +T S L+ Q + H W L S
Sbjct: 530 PRS-EIS-VQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEK 587
Query: 727 ---------KSRWVIVGLFVSILILSLVFASRLR 751
K++ V++ LF+ +L +SL +R+R
Sbjct: 588 HYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVR 621
Score = 32.3 bits (72), Expect = 3.3
Identities = 35/167 (20%), Positives = 67/167 (40%), Gaps = 39/167 (23%)
Query: 1205 ILLLLPVLLSILGIVCLVVTIMYWS----------------------GWEMGAVEAISLS 1242
+LL + V+L+ +VC V + W+ G ++ AV + L
Sbjct: 877 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 936
Query: 1243 ILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVI 1302
VG V++ VH+ +L A + R + A+ H+ ++ A++T++
Sbjct: 937 ASVGIGVEFTVHVALAFL------------TAIGDKNRRAVLALEHMFAPVLDGAVSTLL 984
Query: 1303 ATVPLF---FCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346
+ L F I + F ++A+ T + +L L + LL P
Sbjct: 985 GVLMLAGSEFDFIVRY--FFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
>gi|134254468 patched isoform S [Homo sapiens]
Length = 1296
Score = 53.1 bits (126), Expect = 2e-06
Identities = 87/394 (22%), Positives = 152/394 (38%), Gaps = 65/394 (16%)
Query: 415 WEEQRAK--FQSFVVTYVAML----AKQSTSKVQVLYGGT------DLFDYEVRRTFNND 462
W E +A +++ TYV ++ A+ ST KV T D V R +
Sbjct: 236 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGY 295
Query: 463 MLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVA 522
+L+ ++ +C+ L + + + G+ + LS L L ++ GI + V
Sbjct: 296 LLM--LAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLI-GISFNAATTQVL 352
Query: 523 AFVIVGIGVDDVFVFINTYRQATH-----LEDPQLRMIHTVQTAGKATFFTSLTTAAAYA 577
F+ +G+GVDDVF+ + + + ED R ++ G + TS++ A+
Sbjct: 353 PFLALGVGVDDVFLLAHAFSETGQNKRIPFED---RTGECLKRTGASVALTSISNVTAFF 409
Query: 578 ANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL------------WSLYLAP--- 622
IPA+ F L +++V + VL+ PA L + + + +P
Sbjct: 410 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVS 469
Query: 623 ----LESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEE 678
+E T H N + FA Q+ D + E
Sbjct: 470 RVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAE 529
Query: 679 PVSLELGDVSLVSVSPEGL--QPASNTGSRGHLIVQLQELLHH--------WVLWSAV-- 726
P S E+ V V+V+ + L Q +T S L+ Q + H W L S
Sbjct: 530 PRS-EIS-VQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEK 587
Query: 727 ---------KSRWVIVGLFVSILILSLVFASRLR 751
K++ V++ LF+ +L +SL +R+R
Sbjct: 588 HYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVR 621
Score = 32.3 bits (72), Expect = 3.3
Identities = 35/167 (20%), Positives = 67/167 (40%), Gaps = 39/167 (23%)
Query: 1205 ILLLLPVLLSILGIVCLVVTIMYWS----------------------GWEMGAVEAISLS 1242
+LL + V+L+ +VC V + W+ G ++ AV + L
Sbjct: 877 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 936
Query: 1243 ILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVI 1302
VG V++ VH+ +L A + R + A+ H+ ++ A++T++
Sbjct: 937 ASVGIGVEFTVHVALAFL------------TAIGDKNRRAVLALEHMFAPVLDGAVSTLL 984
Query: 1303 ATVPLF---FCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346
+ L F I + F ++A+ T + +L L + LL P
Sbjct: 985 GVLMLAGSEFDFIVRY--FFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
>gi|134254452 patched isoform S [Homo sapiens]
Length = 1296
Score = 53.1 bits (126), Expect = 2e-06
Identities = 87/394 (22%), Positives = 152/394 (38%), Gaps = 65/394 (16%)
Query: 415 WEEQRAK--FQSFVVTYVAML----AKQSTSKVQVLYGGT------DLFDYEVRRTFNND 462
W E +A +++ TYV ++ A+ ST KV T D V R +
Sbjct: 236 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGY 295
Query: 463 MLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVA 522
+L+ ++ +C+ L + + + G+ + LS L L ++ GI + V
Sbjct: 296 LLM--LAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLI-GISFNAATTQVL 352
Query: 523 AFVIVGIGVDDVFVFINTYRQATH-----LEDPQLRMIHTVQTAGKATFFTSLTTAAAYA 577
F+ +G+GVDDVF+ + + + ED R ++ G + TS++ A+
Sbjct: 353 PFLALGVGVDDVFLLAHAFSETGQNKRIPFED---RTGECLKRTGASVALTSISNVTAFF 409
Query: 578 ANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL------------WSLYLAP--- 622
IPA+ F L +++V + VL+ PA L + + + +P
Sbjct: 410 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVS 469
Query: 623 ----LESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEE 678
+E T H N + FA Q+ D + E
Sbjct: 470 RVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAE 529
Query: 679 PVSLELGDVSLVSVSPEGL--QPASNTGSRGHLIVQLQELLHH--------WVLWSAV-- 726
P S E+ V V+V+ + L Q +T S L+ Q + H W L S
Sbjct: 530 PRS-EIS-VQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEK 587
Query: 727 ---------KSRWVIVGLFVSILILSLVFASRLR 751
K++ V++ LF+ +L +SL +R+R
Sbjct: 588 HYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVR 621
Score = 32.3 bits (72), Expect = 3.3
Identities = 35/167 (20%), Positives = 67/167 (40%), Gaps = 39/167 (23%)
Query: 1205 ILLLLPVLLSILGIVCLVVTIMYWS----------------------GWEMGAVEAISLS 1242
+LL + V+L+ +VC V + W+ G ++ AV + L
Sbjct: 877 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 936
Query: 1243 ILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVI 1302
VG V++ VH+ +L A + R + A+ H+ ++ A++T++
Sbjct: 937 ASVGIGVEFTVHVALAFL------------TAIGDKNRRAVLALEHMFAPVLDGAVSTLL 984
Query: 1303 ATVPLF---FCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346
+ L F I + F ++A+ T + +L L + LL P
Sbjct: 985 GVLMLAGSEFDFIVRY--FFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
>gi|134254432 patched isoform L' [Homo sapiens]
Length = 1446
Score = 53.1 bits (126), Expect = 2e-06
Identities = 87/394 (22%), Positives = 152/394 (38%), Gaps = 65/394 (16%)
Query: 415 WEEQRAK--FQSFVVTYVAML----AKQSTSKVQVLYGGT------DLFDYEVRRTFNND 462
W E +A +++ TYV ++ A+ ST KV T D V R +
Sbjct: 386 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGY 445
Query: 463 MLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVA 522
+L+ ++ +C+ L + + + G+ + LS L L ++ GI + V
Sbjct: 446 LLM--LAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLI-GISFNAATTQVL 502
Query: 523 AFVIVGIGVDDVFVFINTYRQATH-----LEDPQLRMIHTVQTAGKATFFTSLTTAAAYA 577
F+ +G+GVDDVF+ + + + ED R ++ G + TS++ A+
Sbjct: 503 PFLALGVGVDDVFLLAHAFSETGQNKRIPFED---RTGECLKRTGASVALTSISNVTAFF 559
Query: 578 ANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL------------WSLYLAP--- 622
IPA+ F L +++V + VL+ PA L + + + +P
Sbjct: 560 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVS 619
Query: 623 ----LESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEE 678
+E T H N + FA Q+ D + E
Sbjct: 620 RVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAE 679
Query: 679 PVSLELGDVSLVSVSPEGL--QPASNTGSRGHLIVQLQELLHH--------WVLWSAV-- 726
P S E+ V V+V+ + L Q +T S L+ Q + H W L S
Sbjct: 680 PRS-EIS-VQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEK 737
Query: 727 ---------KSRWVIVGLFVSILILSLVFASRLR 751
K++ V++ LF+ +L +SL +R+R
Sbjct: 738 HYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVR 771
Score = 32.3 bits (72), Expect = 3.3
Identities = 35/167 (20%), Positives = 67/167 (40%), Gaps = 39/167 (23%)
Query: 1205 ILLLLPVLLSILGIVCLVVTIMYWS----------------------GWEMGAVEAISLS 1242
+LL + V+L+ +VC V + W+ G ++ AV + L
Sbjct: 1027 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 1086
Query: 1243 ILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVI 1302
VG V++ VH+ +L A + R + A+ H+ ++ A++T++
Sbjct: 1087 ASVGIGVEFTVHVALAFL------------TAIGDKNRRAVLALEHMFAPVLDGAVSTLL 1134
Query: 1303 ATVPLF---FCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346
+ L F I + F ++A+ T + +L L + LL P
Sbjct: 1135 GVLMLAGSEFDFIVRY--FFAVLAILTILGVLNGLVLLPVLLSFFGP 1179
>gi|134254466 patched isoform M [Homo sapiens]
Length = 1381
Score = 53.1 bits (126), Expect = 2e-06
Identities = 87/394 (22%), Positives = 152/394 (38%), Gaps = 65/394 (16%)
Query: 415 WEEQRAK--FQSFVVTYVAML----AKQSTSKVQVLYGGT------DLFDYEVRRTFNND 462
W E +A +++ TYV ++ A+ ST KV T D V R +
Sbjct: 321 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGY 380
Query: 463 MLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVA 522
+L+ ++ +C+ L + + + G+ + LS L L ++ GI + V
Sbjct: 381 LLM--LAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLI-GISFNAATTQVL 437
Query: 523 AFVIVGIGVDDVFVFINTYRQATH-----LEDPQLRMIHTVQTAGKATFFTSLTTAAAYA 577
F+ +G+GVDDVF+ + + + ED R ++ G + TS++ A+
Sbjct: 438 PFLALGVGVDDVFLLAHAFSETGQNKRIPFED---RTGECLKRTGASVALTSISNVTAFF 494
Query: 578 ANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL------------WSLYLAP--- 622
IPA+ F L +++V + VL+ PA L + + + +P
Sbjct: 495 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVS 554
Query: 623 ----LESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEE 678
+E T H N + FA Q+ D + E
Sbjct: 555 RVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAE 614
Query: 679 PVSLELGDVSLVSVSPEGL--QPASNTGSRGHLIVQLQELLHH--------WVLWSAV-- 726
P S E+ V V+V+ + L Q +T S L+ Q + H W L S
Sbjct: 615 PRS-EIS-VQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEK 672
Query: 727 ---------KSRWVIVGLFVSILILSLVFASRLR 751
K++ V++ LF+ +L +SL +R+R
Sbjct: 673 HYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVR 706
Score = 32.3 bits (72), Expect = 3.3
Identities = 35/167 (20%), Positives = 67/167 (40%), Gaps = 39/167 (23%)
Query: 1205 ILLLLPVLLSILGIVCLVVTIMYWS----------------------GWEMGAVEAISLS 1242
+LL + V+L+ +VC V + W+ G ++ AV + L
Sbjct: 962 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 1021
Query: 1243 ILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVI 1302
VG V++ VH+ +L A + R + A+ H+ ++ A++T++
Sbjct: 1022 ASVGIGVEFTVHVALAFL------------TAIGDKNRRAVLALEHMFAPVLDGAVSTLL 1069
Query: 1303 ATVPLF---FCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346
+ L F I + F ++A+ T + +L L + LL P
Sbjct: 1070 GVLMLAGSEFDFIVRY--FFAVLAILTILGVLNGLVLLPVLLSFFGP 1114
>gi|134254446 patched isoform L [Homo sapiens]
Length = 1447
Score = 53.1 bits (126), Expect = 2e-06
Identities = 87/394 (22%), Positives = 152/394 (38%), Gaps = 65/394 (16%)
Query: 415 WEEQRAK--FQSFVVTYVAML----AKQSTSKVQVLYGGT------DLFDYEVRRTFNND 462
W E +A +++ TYV ++ A+ ST KV T D V R +
Sbjct: 387 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGY 446
Query: 463 MLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVA 522
+L+ ++ +C+ L + + + G+ + LS L L ++ GI + V
Sbjct: 447 LLM--LAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLI-GISFNAATTQVL 503
Query: 523 AFVIVGIGVDDVFVFINTYRQATH-----LEDPQLRMIHTVQTAGKATFFTSLTTAAAYA 577
F+ +G+GVDDVF+ + + + ED R ++ G + TS++ A+
Sbjct: 504 PFLALGVGVDDVFLLAHAFSETGQNKRIPFED---RTGECLKRTGASVALTSISNVTAFF 560
Query: 578 ANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL------------WSLYLAP--- 622
IPA+ F L +++V + VL+ PA L + + + +P
Sbjct: 561 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVS 620
Query: 623 ----LESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEE 678
+E T H N + FA Q+ D + E
Sbjct: 621 RVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAE 680
Query: 679 PVSLELGDVSLVSVSPEGL--QPASNTGSRGHLIVQLQELLHH--------WVLWSAV-- 726
P S E+ V V+V+ + L Q +T S L+ Q + H W L S
Sbjct: 681 PRS-EIS-VQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEK 738
Query: 727 ---------KSRWVIVGLFVSILILSLVFASRLR 751
K++ V++ LF+ +L +SL +R+R
Sbjct: 739 HYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVR 772
Score = 32.3 bits (72), Expect = 3.3
Identities = 35/167 (20%), Positives = 67/167 (40%), Gaps = 39/167 (23%)
Query: 1205 ILLLLPVLLSILGIVCLVVTIMYWS----------------------GWEMGAVEAISLS 1242
+LL + V+L+ +VC V + W+ G ++ AV + L
Sbjct: 1028 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 1087
Query: 1243 ILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVI 1302
VG V++ VH+ +L A + R + A+ H+ ++ A++T++
Sbjct: 1088 ASVGIGVEFTVHVALAFL------------TAIGDKNRRAVLALEHMFAPVLDGAVSTLL 1135
Query: 1303 ATVPLF---FCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346
+ L F I + F ++A+ T + +L L + LL P
Sbjct: 1136 GVLMLAGSEFDFIVRY--FFAVLAILTILGVLNGLVLLPVLLSFFGP 1180
>gi|194018513 patched domain containing 3 [Homo sapiens]
Length = 767
Score = 50.1 bits (118), Expect = 2e-05
Identities = 35/152 (23%), Positives = 73/152 (48%), Gaps = 12/152 (7%)
Query: 473 IAALVYILTSCSVF--------LSFFGIASIGLSCLVAL-FLYHVVFGIQYLGILNGVAA 523
I +++ +TSC F ++ FG+ S L+ + L H+ G+ ++ I+ +
Sbjct: 392 ILIILFAVTSCFRFDCIRNKMCVAAFGVISAFLAVVSGFGLLLHI--GVPFV-IIVANSP 448
Query: 524 FVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQ 583
F+I+G+GVDD+F+ I+ + + +D + RM + A + T++T A + S
Sbjct: 449 FLILGVGVDDMFIMISAWHKTNLADDIRERMSNVYSKAAVSITITTITNILALYTGIMSS 508
Query: 584 IPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
+V F ++ + + C+ + A + L
Sbjct: 509 FRSVQCFCIYTGMTLLFCYFYNITCFGAFMAL 540
>gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo
sapiens]
Length = 1332
Score = 49.3 bits (116), Expect = 3e-05
Identities = 58/256 (22%), Positives = 106/256 (41%), Gaps = 24/256 (9%)
Query: 405 LPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDML 464
L NY + D R + + ++F+ A ++ QV + + E+ RT D
Sbjct: 576 LNNYPAGDPRLAQAKLWEEAFLEEMRAF-QRRMAGMFQVTFMAERSLEDEINRTTAED-- 632
Query: 465 LAFISSSCIAALVYILTSCSVFLSF------------FGIASIGLSCLVALFLYHVVFGI 512
L ++S I +YI + + S+ G ++ L ++A + GI
Sbjct: 633 LPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGI 692
Query: 513 QYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGK---ATFFTS 569
+ ++ V F+++ +G D++F+F+ Y++ + R +H + G+ + S
Sbjct: 693 RSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPR-RPGEPREVHIGRALGRVAPSMLLCS 751
Query: 570 LTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSLYLAPLESSCQT 629
L+ A + + +PAV F L L V L L+ M A + L SL E+S
Sbjct: 752 LSEAICFFLGALTPMPAVRTFALTSGLAVI---LDFLLQMSAFVALLSLDSKRQEASRLD 808
Query: 630 SCHQNCSRKTSLHFPG 645
C C + L PG
Sbjct: 809 VC--CCVKPQELPPPG 822
>gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo
sapiens]
Length = 1359
Score = 49.3 bits (116), Expect = 3e-05
Identities = 58/256 (22%), Positives = 106/256 (41%), Gaps = 24/256 (9%)
Query: 405 LPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDML 464
L NY + D R + + ++F+ A ++ QV + + E+ RT D
Sbjct: 576 LNNYPAGDPRLAQAKLWEEAFLEEMRAF-QRRMAGMFQVTFMAERSLEDEINRTTAED-- 632
Query: 465 LAFISSSCIAALVYILTSCSVFLSF------------FGIASIGLSCLVALFLYHVVFGI 512
L ++S I +YI + + S+ G ++ L ++A + GI
Sbjct: 633 LPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGI 692
Query: 513 QYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGK---ATFFTS 569
+ ++ V F+++ +G D++F+F+ Y++ + R +H + G+ + S
Sbjct: 693 RSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPR-RPGEPREVHIGRALGRVAPSMLLCS 751
Query: 570 LTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSLYLAPLESSCQT 629
L+ A + + +PAV F L L V L L+ M A + L SL E+S
Sbjct: 752 LSEAICFFLGALTPMPAVRTFALTSGLAVI---LDFLLQMSAFVALLSLDSKRQEASRLD 808
Query: 630 SCHQNCSRKTSLHFPG 645
C C + L PG
Sbjct: 809 VC--CCVKPQELPPPG 822
>gi|148612890 serine-arginine repressor protein [Homo sapiens]
Length = 261
Score = 35.8 bits (81), Expect = 0.29
Identities = 38/153 (24%), Positives = 65/153 (42%), Gaps = 31/153 (20%)
Query: 127 KSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNRSRQASRAPRVIPAASLGGPGPY 186
+S+ SWGRNRR +D E+ R S + ++SR S P
Sbjct: 121 RSRSSSWGRNRR-RSDSLKESRHRRFS------YSQSKSRSKSL--------------PR 159
Query: 187 RDTSAAQKPTANRS----GRLRRETPPLEDLAANQSEDPRNQRLSKNGRYQPSIPPHA-A 241
R TSA Q T R+ GR R ++ + +S+ Q+ + +G S H+ +
Sbjct: 160 RSTSARQSRTPRRNFGSRGRSRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDS 219
Query: 242 VAANQSRARRGASRWDYSRAYVSANTQTHAHWR 274
+A + ++ +G Y+ + T H+H+R
Sbjct: 220 IARSPCKSPKG-----YTNSETKVQTAKHSHFR 247
>gi|148277106 hypothetical protein LOC442213 [Homo sapiens]
Length = 829
Score = 35.8 bits (81), Expect = 0.29
Identities = 37/177 (20%), Positives = 72/177 (40%), Gaps = 13/177 (7%)
Query: 1173 IFMEIVGVQSALCGLVLSLLICVAAVAVF--TTHILLLLPVLLSILGIVCLVVTIMYWSG 1230
+FM+ + + L+ + + + F H L ++LS+ I V+ +M
Sbjct: 631 VFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLGLMTLWN 690
Query: 1231 WEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVG 1290
+M + + L + ++D+C L+ ++LA E RTQ +++ G
Sbjct: 691 VDMDCISILCLIYTLNFAIDHCAPLLFTFVLA--------TEHTRTQ---CIKSSLQDHG 739
Query: 1291 VAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAPS 1347
AI+ + + +I VPL F K + L G ++L+ + L PS
Sbjct: 740 TAILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFLTFFPPS 796
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 34.3 bits (77), Expect = 0.86
Identities = 34/122 (27%), Positives = 46/122 (37%), Gaps = 25/122 (20%)
Query: 956 CLLSSSP---DGPTKGFFFVPSEKVPKARLSATFGFNPCVNTGCGKPAVR---------- 1002
C+ SP +G KG FV S +VP + +N G A+
Sbjct: 425 CVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSL 484
Query: 1003 -PLVDTGAMV---FVV--------FGIIGVNRTRQVDNHVIGDPGSVVYDSSFDLFKEIG 1050
PL G ++ F V F I G TRQ + +G PG++V F E G
Sbjct: 485 LPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHG 544
Query: 1051 HL 1052
HL
Sbjct: 545 HL 546
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 33.9 bits (76), Expect = 1.1
Identities = 32/123 (26%), Positives = 60/123 (48%), Gaps = 15/123 (12%)
Query: 785 TCSGLFQEKPHSLQNNIRTSL-EKKRRGSGVPWASRPEATLQDFPGTVY-ISKVKSQGHP 842
+CSG+F+ +P S + + T++ E+ R+G G+ + +L G + +++V ++ P
Sbjct: 424 SCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSP 483
Query: 843 AVYRLSLNASLPAPWQAVSPGDG----EVPSFQVYRAPFGNFTKKLTACMSTVGLLQAAS 898
L+ + +P SP +G +F ++P G L+ +T GLL A S
Sbjct: 484 ----LTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAG-----LSGTPATQGLLGACS 534
Query: 899 PSR 901
P R
Sbjct: 535 PVR 537
>gi|170650672 Leber congenital amaurosis 5 [Homo sapiens]
Length = 697
Score = 33.5 bits (75), Expect = 1.5
Identities = 44/196 (22%), Positives = 78/196 (39%), Gaps = 33/196 (16%)
Query: 282 RGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMT 341
+G+ E + L ++EI+R++ D + + VL LP SP S T
Sbjct: 455 QGEEEERLKREMLLAKLNEIDRELQDSRNLK------YPVLPLLPDFESKLHSPERSPKT 508
Query: 342 YFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSADNLKSSLLRSEILF 401
Y F +E +++ G L DI S EG ++ N++S +E F
Sbjct: 509 YRF-SESSERLFN---GHHLQDISFSTPKG-----------EGQNSGNVRSPASPNEFAF 553
Query: 402 GAPLPNYYSVDDRWE--EQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTF 459
G+ +P++ +R Q++ F F Q S ++ G DL + ++
Sbjct: 554 GSYVPSFAKTSERSNPFSQKSSFLDF----------QRNSMEKLSKDGVDLITRKEKKAN 603
Query: 460 NNDMLLAFISSSCIAA 475
+ L SS I++
Sbjct: 604 LMEQLFGASGSSTISS 619
>gi|170650670 Leber congenital amaurosis 5 [Homo sapiens]
Length = 697
Score = 33.5 bits (75), Expect = 1.5
Identities = 44/196 (22%), Positives = 78/196 (39%), Gaps = 33/196 (16%)
Query: 282 RGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMT 341
+G+ E + L ++EI+R++ D + + VL LP SP S T
Sbjct: 455 QGEEEERLKREMLLAKLNEIDRELQDSRNLK------YPVLPLLPDFESKLHSPERSPKT 508
Query: 342 YFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSADNLKSSLLRSEILF 401
Y F +E +++ G L DI S EG ++ N++S +E F
Sbjct: 509 YRF-SESSERLFN---GHHLQDISFSTPKG-----------EGQNSGNVRSPASPNEFAF 553
Query: 402 GAPLPNYYSVDDRWE--EQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTF 459
G+ +P++ +R Q++ F F Q S ++ G DL + ++
Sbjct: 554 GSYVPSFAKTSERSNPFSQKSSFLDF----------QRNSMEKLSKDGVDLITRKEKKAN 603
Query: 460 NNDMLLAFISSSCIAA 475
+ L SS I++
Sbjct: 604 LMEQLFGASGSSTISS 619
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 32.7 bits (73), Expect = 2.5
Identities = 22/98 (22%), Positives = 40/98 (40%)
Query: 154 EQLQQLHLGNRSRQASRAPRVIPAASLGGPGPYRDTSAAQKPTANRSGRLRRETPPLEDL 213
+ + + +G + P P+ S P P + + KP N + L + P DL
Sbjct: 758 KDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDL 817
Query: 214 AANQSEDPRNQRLSKNGRYQPSIPPHAAVAANQSRARR 251
+ E P + + K R + + P +A Q+ A+R
Sbjct: 818 SPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKR 855
>gi|169211642 PREDICTED: hypothetical protein [Homo sapiens]
Length = 378
Score = 32.3 bits (72), Expect = 3.3
Identities = 18/38 (47%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Query: 158 QLHLGNRSRQASRA--PRVIPAASLGGPGPYRDTSAAQ 193
QLH + QA+ A P+ PAAS G PGP R + AQ
Sbjct: 233 QLHAARQRLQAAAAQRPQPAPAASPGAPGPSRPAARAQ 270
>gi|169210857 PREDICTED: similar to RIKEN cDNA E130309D14 [Homo
sapiens]
Length = 378
Score = 32.3 bits (72), Expect = 3.3
Identities = 18/38 (47%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Query: 158 QLHLGNRSRQASRA--PRVIPAASLGGPGPYRDTSAAQ 193
QLH + QA+ A P+ PAAS G PGP R + AQ
Sbjct: 233 QLHAARQRLQAAAAQRPQPAPAASPGAPGPSRPAARAQ 270
>gi|92091572 dedicator of cytokinesis 4 [Homo sapiens]
Length = 1966
Score = 32.3 bits (72), Expect = 3.3
Identities = 25/86 (29%), Positives = 33/86 (38%), Gaps = 13/86 (15%)
Query: 172 PRVIPAASLGGPGPYRDTSAAQKPTANRSGRLRRETPPLEDLAANQSEDPRNQRLSKNGR 231
P +P S GG P R S P + LRR P L+ + +P
Sbjct: 1879 PVPVPVPSYGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPVTSEP---------- 1928
Query: 232 YQPSIPPHAAVAANQSRARRGASRWD 257
P++PP +AA S GA R D
Sbjct: 1929 --PALPP-KPLAARSSHLENGARRTD 1951
>gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo
sapiens]
Length = 4911
Score = 32.3 bits (72), Expect = 3.3
Identities = 28/99 (28%), Positives = 43/99 (43%), Gaps = 24/99 (24%)
Query: 172 PRVIPAASLGGPGPYRDTS----AAQKPTANRSGRLRR------ETP-----PLEDLAAN 216
P + PA GPGP++ ++Q P + S RR E P P+++ + N
Sbjct: 2029 PLLTPAPLDSGPGPFKTPMQPPPSSQDPYGSVSQASRRLSVDPYERPALTPRPIDNFSHN 2088
Query: 217 QSEDPRNQRLSKNGRYQPSIPPHAAVAANQSRARRGASR 255
QS DP + QP + PH AV + + R S+
Sbjct: 2089 QSNDPYS---------QPPLTPHPAVNESFAHPSRAFSQ 2118
>gi|189011544 ubiquitously transcribed tetratricopeptide repeat, X
chromosome [Homo sapiens]
Length = 1401
Score = 32.0 bits (71), Expect = 4.3
Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 16/104 (15%)
Query: 622 PLESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDD---IP-----LL 673
PL + ++ H CS +L + + GS + G +PYL + +P L
Sbjct: 566 PLANGPFSAGHVPCSTSRTLGSTDTILIGNNHITGSGSNGNVPYLQRNALTLPHNRTNLT 625
Query: 674 EVEEEPVSLELGD--------VSLVSVSPEGLQPASNTGSRGHL 709
EEP +L + S S P G +P S+TG HL
Sbjct: 626 SSAEEPWKNQLSNSTQGLHKGQSSHSAGPNGERPLSSTGPSQHL 669
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 32.0 bits (71), Expect = 4.3
Identities = 31/101 (30%), Positives = 42/101 (41%), Gaps = 14/101 (13%)
Query: 148 LQRLISEQLQQLHLGNRSRQASRAPRVIPAASLGGPGPYRDTSAAQKPTANRSGRLRRET 207
L I+ +LQ + A P+ P LG PG A +P A RS RL
Sbjct: 1184 LDTAITSRLQLQTPPGSATAADLRPKQPPGRGLG-PGR---AQAGARPPAPRSPRL---- 1235
Query: 208 PPLEDLAANQSEDPRNQRLSK------NGRYQPSIPPHAAV 242
P A N S PR+Q LS+ + + +P +PP V
Sbjct: 1236 PASTSAARNASASPRSQSLSRRESPSPSHQARPGVPPPRGV 1276
>gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]
Length = 484
Score = 31.6 bits (70), Expect = 5.6
Identities = 26/97 (26%), Positives = 42/97 (43%), Gaps = 3/97 (3%)
Query: 144 TSETLQRLISEQLQQLHLGNRSRQASRAPRVIPAASLGGPGPYRDTSAAQKPTANRSGRL 203
+S +R S ++ H +RSR+ S++PR + S R TS + +
Sbjct: 262 SSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKK 321
Query: 204 RRETPPLEDLAANQSED---PRNQRLSKNGRYQPSIP 237
R +TPP A +S R +R S++G P P
Sbjct: 322 RSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKP 358
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 31.6 bits (70), Expect = 5.6
Identities = 29/91 (31%), Positives = 39/91 (42%), Gaps = 4/91 (4%)
Query: 134 GRNRRDLADFTSETLQRLISEQLQQLHLGNRSRQASRAPRV-IPAASLGGPGPYRDTSAA 192
G N D + E +R + Q L +S+ S P IP AS G PGP T
Sbjct: 510 GMNPADKPAWAREVEERTRMNKQQNSPLA-KSKPGSTGPEPPIPQASPGPPGPLSQTPPM 568
Query: 193 QKPTANRSGRLRR-ETPPLEDLAA-NQSEDP 221
Q+P + G + + P +LAA S DP
Sbjct: 569 QRPVEPQEGPHKSLQDQPTRNLAAFPASHDP 599
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,363,466
Number of Sequences: 37866
Number of extensions: 2740096
Number of successful extensions: 7953
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 7832
Number of HSP's gapped (non-prelim): 137
length of query: 1392
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1277
effective length of database: 13,892,928
effective search space: 17741269056
effective search space used: 17741269056
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.