NPC1 29990

Name: NPC1	Sequence: fasta or formatted (1278aa)		NCBI GI: 4557803
Description: Niemann-Pick disease, type C1 precursor		Referenced in: Hedgehog and Related Pathways Additional Membrane Functions
Composition: Amino acid Percentage Count Longest homopolymer A alanine 6.9 88 2 C cysteine 3.8 49 2 D aspartate 5.4 69 2 E glutamate 3.8 48 2 F phenylalanine 7.0 89 3 G glycine 6.3 81 2 H histidine 1.5 19 1 I isoleucine 5.6 71 2 K lysine 3.3 42 2 L leucine 10.5 134 6 M methionine 2.3 30 1 N asparagine 4.8 61 2 P proline 5.1 65 5 Q glutamine 3.8 49 2 R arginine 3.6 46 2 S serine 7.7 99 2 T threonine 5.0 64 2 V valine 8.2 105 2 W tryptophan 1.2 15 1 Y tyrosine 4.2 54 2			Comparative genomics: Search single species RefSeq proteins at NCBI H. sapiens M. musculus D. rerio C. intestinalis S. purpuratus D. melanogaster C. elegans A. thaliana S. cerevisiae E. coli W3110 A. pernix K1 Search summary Figure data Additional searches of RefSeq proteins at NCBI All Eukaryotes Bacteria Archaea Viruses Primates Mammals Vertebrates
Related human proteins: Protein Relative score Description Self-match 1.000 Niemann-Pick disease, type C1 precursor NPC1L1 0.340 Niemann-Pick C1-like protein 1 isoform 2 NPC1L1 0.336 Niemann-Pick C1-like protein 1 isoform 1 PTCH1 0.041 patched isoform S PTCH1 0.041 patched isoform S PTCH1 0.041 patched isoform S PTCH1 0.041 patched isoform S PTCH1 0.041 patched isoform L' PTCH1 0.041 patched isoform M PTCH1 0.041 patched isoform L PTCH2 0.037 patched 2 PTCHD3 0.032 patched domain containing 3 C6orf138 0.029 hypothetical protein LOC442213 PTCHD1 0.024 patched domain containing 1 SCAP 0.022 SREBF chaperone protein PTCHD2 0.015 patched domain containing 2 DISP1 0.012 dispatched A HMGCR 0.009 3-hydroxy-3-methylglutaryl-Coenzyme A reductase iso... HMGCR 0.009 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isofo... DISP2 0.008 dispatched B IRS1 0.003 insulin receptor substrate 1 PPP1R15B 0.003 protein phosphatase 1, regulatory subunit 15B [Homo... TAF1 0.003 TBP-associated factor 1 isoform 2 TAF1 0.003 TBP-associated factor 1 isoform 1 XKR6 0.003 XK, Kell blood group complex subunit-related family,... SLC46A3 0.003 solute carrier family 46, member 3 isoform a SLC46A3 0.003 solute carrier family 46, member 3 isoform b EIF3CL 0.003 eukaryotic translation initiation factor 3, subunit... EIF3C 0.003 eukaryotic translation initiation factor 3, subunit ... EIF3C 0.003 eukaryotic translation initiation factor 3, subunit C... Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.