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Search of human proteins with 148664246
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148664246 harmonin-interacting ankyrin-repeat containing
protein [Homo sapiens]
(417 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148664246 harmonin-interacting ankyrin-repeat containing prot... 830 0.0
gi|34304383 Usher syndrome 1G protein [Homo sapiens] 335 3e-92
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 79 1e-14
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 70 5e-12
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 67 3e-11
gi|16975496 cortactin binding protein 2 [Homo sapiens] 65 9e-11
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 65 1e-10
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 65 1e-10
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 63 4e-10
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 63 4e-10
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 63 4e-10
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 63 4e-10
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 63 4e-10
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 63 6e-10
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 63 6e-10
gi|54792780 DDHD domain containing 2 [Homo sapiens] 62 7e-10
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 62 7e-10
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 62 7e-10
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 61 2e-09
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 60 3e-09
gi|110431370 espin [Homo sapiens] 60 4e-09
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 60 4e-09
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 60 5e-09
gi|34304381 inversin isoform a [Homo sapiens] 60 5e-09
gi|34304379 inversin isoform b [Homo sapiens] 60 5e-09
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 60 5e-09
gi|118498337 HECT domain containing 1 [Homo sapiens] 59 6e-09
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 59 6e-09
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 59 8e-09
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 59 8e-09
>gi|148664246 harmonin-interacting ankyrin-repeat containing protein
[Homo sapiens]
Length = 417
Score = 830 bits (2144), Expect = 0.0
Identities = 417/417 (100%), Positives = 417/417 (100%)
Query: 1 MSTRYHQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
MSTRYHQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR
Sbjct: 1 MSTRYHQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA
Sbjct: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKGTF 180
ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKGTF
Sbjct: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKGTF 180
Query: 181 SRSSPSNASAPGTFGSLSKGIKDTFKIKFKKNKDTAEQVGKEGRSGQRNVMEVFREEEED 240
SRSSPSNASAPGTFGSLSKGIKDTFKIKFKKNKDTAEQVGKEGRSGQRNVMEVFREEEED
Sbjct: 181 SRSSPSNASAPGTFGSLSKGIKDTFKIKFKKNKDTAEQVGKEGRSGQRNVMEVFREEEED 240
Query: 241 SFSGDFKEKLQLSAEEDGSVHHESILNRPGLGSIVFRRNRISSPEDISDSKREFGFKLPS 300
SFSGDFKEKLQLSAEEDGSVHHESILNRPGLGSIVFRRNRISSPEDISDSKREFGFKLPS
Sbjct: 241 SFSGDFKEKLQLSAEEDGSVHHESILNRPGLGSIVFRRNRISSPEDISDSKREFGFKLPS 300
Query: 301 ELLQRQGASEADEGAADEEGEENGLKDDLPWDDDEVEWEEDVVDATPLEVFLLSQHLEEF 360
ELLQRQGASEADEGAADEEGEENGLKDDLPWDDDEVEWEEDVVDATPLEVFLLSQHLEEF
Sbjct: 301 ELLQRQGASEADEGAADEEGEENGLKDDLPWDDDEVEWEEDVVDATPLEVFLLSQHLEEF 360
Query: 361 LPIFKREQIDLEALLLCSDEDLQSIQMQLGPRKKVLNAINRRKQVLQQPGQLVDTSL 417
LPIFKREQIDLEALLLCSDEDLQSIQMQLGPRKKVLNAINRRKQVLQQPGQLVDTSL
Sbjct: 361 LPIFKREQIDLEALLLCSDEDLQSIQMQLGPRKKVLNAINRRKQVLQQPGQLVDTSL 417
>gi|34304383 Usher syndrome 1G protein [Homo sapiens]
Length = 461
Score = 335 bits (860), Expect = 3e-92
Identities = 199/464 (42%), Positives = 270/464 (58%), Gaps = 50/464 (10%)
Query: 1 MSTRYHQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
M+ +YH+AA D YLELLKEAT+++LN DEDGMTPTL AAYHGNLE+L +I SRGGDPD+
Sbjct: 1 MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDK 60
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
CDIWGNTPLH AASNGH HC+SFLV+FGANI+ LDND TPLD AA + ECV LD
Sbjct: 61 CDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSI 120
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSK---EESGTLSSSK 177
A Q+ +NPK V +LK++A + A R+I+EC +LQ +H +M Y + E S TLS S
Sbjct: 121 AAKQSSLNPKLVGKLKDKAFREAERRIRECAKLQRRHHERMERRYRRELAERSDTLSFSS 180
Query: 178 GTFSRSSP-------------SNASAPGTFGSLSK----------GIKDTFKIKFKKNKD 214
T S S S A+ GT +K G + TFK+ K
Sbjct: 181 LTSSTLSRRLQHLALGSHLPYSQATLHGTARGKTKMQKKLERRKQGGEGTFKVSEDGRKS 240
Query: 215 TAEQVGKEGRS----------------GQRNVMEVFREEEEDSFSGDFKEKLQLSAEEDG 258
G + S G+ + ++F +EDS S +E
Sbjct: 241 ARSLSGLQLGSDVMFVRQGTYANPKEWGRAPLRDMFL-SDEDSVSRATLAAEPAHSEVST 299
Query: 259 SVHHESILNRPGLGSIVFRRNRISSPEDISDSKRE----FGFKLPSELLQRQGASEADEG 314
H+S+ RPGLG++VFRRN +SS + RE G P LQ + + D
Sbjct: 300 DSGHDSLFTRPGLGTMVFRRNYLSS--GLHGLGREDGGLDGVGAPRGRLQSSPSLDDDSL 357
Query: 315 AADEEGEENGLKDDLPWDDDEVEWEEDV-VDATPLEVFLLSQHLEEFLPIFKREQIDLEA 373
+ ++ ++LPWD+ ++ +ED+ + +PLE FL S H+E+F + ++E+IDLEA
Sbjct: 358 GSANSLQDRSCGEELPWDELDLGLDEDLEPETSPLETFLASLHMEDFAALLRQEKIDLEA 417
Query: 374 LLLCSDEDLQSIQMQLGPRKKVLNAINRRKQVLQQPGQLVDTSL 417
L+LCSD DL+SI + LGPRKK+L A+ RR+Q +++P L DT L
Sbjct: 418 LMLCSDLDLRSISVPLGPRKKILGAVRRRRQAMERPPALEDTEL 461
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 78.6 bits (192), Expect = 1e-14
Identities = 51/124 (41%), Positives = 73/124 (58%), Gaps = 5/124 (4%)
Query: 9 ASDSYLELLKEATKRDLNLSDEDG---MTPTLLAAYHGNLEALEIICSRGGDPDRCDIWG 65
AS++ L++L E + D+ LSD D ++P LAAYHG+ +ALE++ D D + G
Sbjct: 525 ASETPLDVLMETSGTDM-LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSG 583
Query: 66 NTPLHFAASNGHAHCVSFLVNFGANIFALDNDL-QTPLDAAASREQNECVALLDKAATAQ 124
TPL AA GH CV L+N GA+I D L +TP+ AAA+ +EC+ LL A Q
Sbjct: 584 RTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQ 643
Query: 125 NIMN 128
N ++
Sbjct: 644 NAVD 647
Score = 61.6 bits (148), Expect = 1e-09
Identities = 38/126 (30%), Positives = 63/126 (50%), Gaps = 6/126 (4%)
Query: 3 TRYHQAASDSYLELLK-----EATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGD 57
T H AA++ + E L+ + +++ D +G TP +L+ +G+ + + + ++G +
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGAN 678
Query: 58 PDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLD-AAASREQNECVAL 116
D D WG T LH A GH CV L+ GA D+ +TP+ +AA AL
Sbjct: 679 VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738
Query: 117 LDKAAT 122
L AA+
Sbjct: 739 LQSAAS 744
Score = 60.5 bits (145), Expect = 3e-09
Identities = 36/95 (37%), Positives = 54/95 (56%), Gaps = 1/95 (1%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
D++ D+ G T AA GNLE L ++ + G D ++ D +G +PLH+AA+N + C+
Sbjct: 397 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFA 456
Query: 84 LVNFGANIFALDNDLQTPLD-AAASREQNECVALL 117
LV GA++ LD TPL AA S +C+ L
Sbjct: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYL 491
Score = 56.6 bits (135), Expect = 4e-08
Identities = 37/127 (29%), Positives = 57/127 (44%)
Query: 22 KRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCV 81
K D+N D + TP AAY G+ E +E++ G + D TPLH A ++ V
Sbjct: 31 KEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAV 90
Query: 82 SFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQK 141
L+ A++ A D + QTPL AA+ + +C L + N+ + T L A
Sbjct: 91 QVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFS 150
Query: 142 NARRQIK 148
+K
Sbjct: 151 GHGEMVK 157
Score = 55.5 bits (132), Expect = 9e-08
Identities = 33/105 (31%), Positives = 51/105 (48%), Gaps = 1/105 (0%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFL 84
+N +D G TP AA+ ++E L+++ S + D G TPL AA NG + V L
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Query: 85 V-NFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMN 128
V + A + DN T L A S+ L+ + T +N++N
Sbjct: 876 VSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLIN 920
Score = 54.7 bits (130), Expect = 2e-07
Identities = 31/84 (36%), Positives = 46/84 (54%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
++N+SD G T AA+ G+ E ++++ SRG + + D +H+AA GH V
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
Query: 84 LVNFGANIFALDNDLQTPLDAAAS 107
LV+ GA + D TPL AAAS
Sbjct: 192 LVSHGAEVTCKDKKSYTPLHAAAS 215
Score = 53.9 bits (128), Expect = 3e-07
Identities = 39/115 (33%), Positives = 53/115 (46%), Gaps = 5/115 (4%)
Query: 3 TRYHQAASDSY----LELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDP 58
T H AA+ ++ LELL D+N+ +DG TP + A HG + I G
Sbjct: 274 TPLHFAAASTHGALCLELLV-GNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVI 332
Query: 59 DRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNEC 113
D D GNTPLH AA GH ++ L+ GA+ PL AA ++C
Sbjct: 333 DCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDC 387
Score = 53.5 bits (127), Expect = 3e-07
Identities = 39/136 (28%), Positives = 67/136 (49%), Gaps = 6/136 (4%)
Query: 1 MSTRY-HQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
++ RY H+ ++ + + KR ++ GM P LAA G + + S G D D
Sbjct: 345 IAARYGHELLINTLITSGADTAKRGIH-----GMFPLHLAALSGFSDCCRKLLSSGFDID 399
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDK 119
D +G T LH AA+ G+ C++ L+N GA+ D ++PL AA+ +C+ L
Sbjct: 400 TPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVG 459
Query: 120 AATAQNIMNPKKVTRL 135
+ + N ++ + T L
Sbjct: 460 SGASVNDLDERGCTPL 475
Score = 52.0 bits (123), Expect = 1e-06
Identities = 40/135 (29%), Positives = 61/135 (45%), Gaps = 2/135 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + E++K R N++ D+ AAY G++E ++++ S G +
Sbjct: 142 TALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTC 201
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
D TPLH AAS+G V +L++ G ++ + TPL A Q+ V L
Sbjct: 202 KDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDC 261
Query: 121 ATAQNIMNPKKVTRL 135
N N K T L
Sbjct: 262 GAIVNQKNEKGFTPL 276
Score = 50.8 bits (120), Expect = 2e-06
Identities = 31/93 (33%), Positives = 51/93 (54%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFL 84
++ D++G TP +AA +G+ + + + G D + I G PLH AA +G + C L
Sbjct: 332 IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKL 391
Query: 85 VNFGANIFALDNDLQTPLDAAASREQNECVALL 117
++ G +I D+ +T L AAA+ EC+ LL
Sbjct: 392 LSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLL 424
Score = 49.3 bits (116), Expect = 6e-06
Identities = 36/115 (31%), Positives = 56/115 (48%), Gaps = 3/115 (2%)
Query: 6 HQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H AA ++E++K ++ D+ TP AA G + ++ + G D + +
Sbjct: 178 HWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNA 237
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLD-AAASREQNECVALL 117
+GNTPLH A NG V+ L++ GA + + TPL AAAS C+ LL
Sbjct: 238 YGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 292
Score = 48.5 bits (114), Expect = 1e-05
Identities = 41/148 (27%), Positives = 62/148 (41%), Gaps = 2/148 (1%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H+A + E ++ K D+N D++ TP +AA + ++ E + + +
Sbjct: 76 TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV 135
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
D G T LH AA +GH V L++ GANI A D + + AA E V LL
Sbjct: 136 SDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIK 148
+ K T L A +K
Sbjct: 196 GAEVTCKDKKSYTPLHAAASSGMISVVK 223
Score = 43.9 bits (102), Expect = 3e-04
Identities = 32/108 (29%), Positives = 53/108 (49%), Gaps = 4/108 (3%)
Query: 14 LELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWG---NTPLH 70
+E+L + +L L D T LA G+ + +I + D + + TPLH
Sbjct: 872 VEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLH 931
Query: 71 FAASNGHAHCVSFLVNFGANIFALDNDLQTP-LDAAASREQNECVALL 117
AA NG V L+ GA++ A+D + TP L A +++ +C+AL+
Sbjct: 932 VAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALI 979
Score = 43.1 bits (100), Expect = 5e-04
Identities = 35/118 (29%), Positives = 52/118 (44%), Gaps = 3/118 (2%)
Query: 3 TRYHQAASDSYLELLKEA--TKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA+ LE L T D N D+ G +P AA + N + L + G +
Sbjct: 407 TCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVND 466
Query: 61 CDIWGNTPLHFAA-SNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
D G TPLH+AA S+ C+ +L+ AN D + +A+ C+ L+
Sbjct: 467 LDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI 524
Score = 42.7 bits (99), Expect = 6e-04
Identities = 29/93 (31%), Positives = 41/93 (44%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFL 84
+N D +TP A + EA++++ D + D TPLH AA+N C L
Sbjct: 67 VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
Query: 85 VNFGANIFALDNDLQTPLDAAASREQNECVALL 117
V +N+ D +T L AA E V LL
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLL 159
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/129 (29%), Positives = 50/129 (38%), Gaps = 38/129 (29%)
Query: 27 LSDEDGMTPTLLAAYHGNLEALEII----CSRGGDPDRCDIWGNTPLHFAASNGHAHCVS 82
L D G TP L+A G++ L + S +P D G T LH+A NGH CV
Sbjct: 714 LRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVE 773
Query: 83 FLV---------------------------------NFGANIF-ALDNDLQTPLDAAASR 108
L+ GA+I A D+ +TPL AAA
Sbjct: 774 LLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFT 833
Query: 109 EQNECVALL 117
+ EC+ LL
Sbjct: 834 DHVECLQLL 842
Score = 39.3 bits (90), Expect = 0.007
Identities = 32/110 (29%), Positives = 50/110 (45%), Gaps = 1/110 (0%)
Query: 35 PTLLAA-YHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFA 93
P+L+ A ++G+ + + + + D + D TPLH AA G A + L+ GA + A
Sbjct: 10 PSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA 69
Query: 94 LDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNA 143
D+ TPL A + E V +L K + N + T L A A
Sbjct: 70 KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKA 119
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 69.7 bits (169), Expect = 5e-12
Identities = 38/92 (41%), Positives = 60/92 (65%), Gaps = 1/92 (1%)
Query: 29 DEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFG 88
D+DGMTP L+AAY G+++ ++++ G D D D G TPL AAS GHA V+ L+ +G
Sbjct: 745 DKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWG 804
Query: 89 ANIFALDNDLQTPLDAAASREQNECV-ALLDK 119
A + ++D++ +T L A+++ E V LLD+
Sbjct: 805 AAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836
Score = 62.4 bits (150), Expect = 7e-10
Identities = 41/115 (35%), Positives = 57/115 (49%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFL 84
+N D +G T AAY G+L+ + ++ SRG D + D G+TPL AA GH V+ L
Sbjct: 538 VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
Query: 85 VNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQA 139
+ GANI D D T L +AA E V+ L A + + T L+ A
Sbjct: 598 IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAA 652
Score = 57.8 bits (138), Expect = 2e-08
Identities = 40/112 (35%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 11 DSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLH 70
D L LL+ ++N +D +G T + AAY G+ E +E + G + + D+ G T L
Sbjct: 658 DIVLNLLQHGA--EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALS 715
Query: 71 FA-----ASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
A AS GHA VS L++ GA + D D TPL AA + V LL
Sbjct: 716 VAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 767
Score = 57.4 bits (137), Expect = 2e-08
Identities = 61/219 (27%), Positives = 93/219 (42%), Gaps = 16/219 (7%)
Query: 24 DLNLSDEDGMTPTLLAAY-----HGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHA 78
++N D DG T +AA G+ + ++ RG + D CD G TPL AA GH
Sbjct: 702 EVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHV 761
Query: 79 HCVSFLVNFGANIFALDNDLQTPLDAAASREQNECV-ALLDKAATAQNIMNPKKVTRLKE 137
V L+ GA++ DN+ +TPL AAAS V LL A +I + +
Sbjct: 762 DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIA 821
Query: 138 QAQKNARRQIKECER-LQEKHQNKMA----HTYSKEESGTLSSS---KGTFSRSSPSNAS 189
AQ N +R L E H++ H + E + + +G + ++
Sbjct: 822 SAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGR 881
Query: 190 APGTFGSLSKGIKDTFKIKFKKNKDTAEQVGKEGRSGQR 228
P S +G D +I +NK +Q G +GR+ R
Sbjct: 882 IPFILAS-QEGHYDCVQI-LLENKSNIDQRGYDGRNALR 918
Score = 51.6 bits (122), Expect = 1e-06
Identities = 27/104 (25%), Positives = 49/104 (47%), Gaps = 6/104 (5%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G T +AA G+++ ++++ G DP+ D +G T + AA NGH+ + L +GA+
Sbjct: 1045 GATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASS 1104
Query: 92 F------ALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNP 129
+ Q PL + +S+ Q+ + +T M P
Sbjct: 1105 LNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQP 1148
Score = 49.7 bits (117), Expect = 5e-06
Identities = 28/94 (29%), Positives = 43/94 (45%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
D+N D DG + A L E G + + D G T LH + GH V
Sbjct: 938 DVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQV 997
Query: 84 LVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
L+ + A++ A DN+ ++ L +AA + + V LL
Sbjct: 998 LIAYHADVNAADNEKRSALQSAAWQGHVKVVQLL 1031
Score = 48.9 bits (115), Expect = 8e-06
Identities = 34/149 (22%), Positives = 72/149 (48%), Gaps = 3/149 (2%)
Query: 3 TRYHQAASDSYLELLKE--ATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H + ++E+++ A D+N +D + + AA+ G+++ ++++ G D
Sbjct: 981 TALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH 1040
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDK- 119
G T L AA GH V L+ GA+ D +T + AA ++ + LL+K
Sbjct: 1041 TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY 1100
Query: 120 AATAQNIMNPKKVTRLKEQAQKNARRQIK 148
A++ N +P V ++++ ++ +++
Sbjct: 1101 GASSLNGCSPSPVHTMEQKPLQSLSSKVQ 1129
Score = 48.5 bits (114), Expect = 1e-05
Identities = 35/99 (35%), Positives = 47/99 (47%), Gaps = 1/99 (1%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
++N +D+DG T AA+ G+ E + + G D D T L AA GH V
Sbjct: 603 NINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLN 662
Query: 84 LVNFGANIFALDNDLQTPLDAAASREQNECVA-LLDKAA 121
L+ GA + DN+ +T L AAA E V LLD A
Sbjct: 663 LLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGA 701
Score = 48.1 bits (113), Expect = 1e-05
Identities = 30/83 (36%), Positives = 40/83 (48%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
DL + D G TP LAA G+ + + + G + + D G T L AA GH VS
Sbjct: 570 DLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSA 629
Query: 84 LVNFGANIFALDNDLQTPLDAAA 106
L+ G + D D +T L AAA
Sbjct: 630 LLYAGVKVDCADADSRTALRAAA 652
Score = 45.8 bits (107), Expect = 7e-05
Identities = 32/112 (28%), Positives = 50/112 (44%), Gaps = 2/112 (1%)
Query: 8 AASDSYLELLKEATKRDL--NLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWG 65
A++ +E+++ R L N D+ G TP +AA+ G+ E + +G + D G
Sbjct: 821 ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
Query: 66 NTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
P A+ GH CV L+ +NI D + L AA + V LL
Sbjct: 881 RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELL 932
Score = 42.0 bits (97), Expect = 0.001
Identities = 33/111 (29%), Positives = 48/111 (43%), Gaps = 4/111 (3%)
Query: 3 TRYHQAASDSY---LELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
T H AA + + E L E R N D DG P +LA+ G+ + ++I+ + D
Sbjct: 849 TPLHMAAFEGHRLICEALIEQGART-NEIDNDGRIPFILASQEGHYDCVQILLENKSNID 907
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQ 110
+ G L AA GH V L + GA++ D D + L A Q
Sbjct: 908 QRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958
Score = 40.0 bits (92), Expect = 0.004
Identities = 28/103 (27%), Positives = 48/103 (46%)
Query: 15 ELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAAS 74
E+L+ K +++ ED T ++ +++ + G ++CD G T L AA
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAY 554
Query: 75 NGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
+G V+ LV+ GA++ D TPL AA + + V L
Sbjct: 555 SGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
Score = 39.3 bits (90), Expect = 0.007
Identities = 25/82 (30%), Positives = 40/82 (48%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFL 84
++ +D D T AA+ G+ + + + G + ++ D G T L AA GH V L
Sbjct: 637 VDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHL 696
Query: 85 VNFGANIFALDNDLQTPLDAAA 106
++ GA + D D +T L AA
Sbjct: 697 LDHGAEVNHEDVDGRTALSVAA 718
Score = 37.7 bits (86), Expect = 0.019
Identities = 28/118 (23%), Positives = 51/118 (43%)
Query: 22 KRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCV 81
K +++ DG +AA G+ + +E++ S G D + D G L+ A
Sbjct: 903 KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMA 962
Query: 82 SFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQA 139
+ + GAN+ A D + +T L + + E V +L N + +K + L+ A
Sbjct: 963 EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA 1020
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 67.0 bits (162), Expect = 3e-11
Identities = 45/136 (33%), Positives = 71/136 (52%), Gaps = 7/136 (5%)
Query: 8 AASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNT 67
A SD +LL +++ D+ G T AA GN+E ++++ S G D + D G T
Sbjct: 358 AHSDCCRKLLSSGF--EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRT 415
Query: 68 PLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIM 127
PLH+AA+N H HC+ LV GAN+ D+ +T L AA+ + + +L A
Sbjct: 416 PLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHD----- 470
Query: 128 NPKKVTRLKEQAQKNA 143
N +++ R +E +K A
Sbjct: 471 NSEELERARELKEKEA 486
Score = 65.5 bits (158), Expect = 9e-11
Identities = 47/117 (40%), Positives = 60/117 (51%), Gaps = 5/117 (4%)
Query: 6 HQAASDSY---LELLKEATKRDLNLSDEDGM-TPTLLAAYHGNLEALEIICSRGGDPDRC 61
H AA+ + LELL E T SD +P LAAY+G+ +ALE++ D D
Sbjct: 512 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571
Query: 62 DIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDN-DLQTPLDAAASREQNECVALL 117
D G T L AA GH CV L+N GA+IF DN +TPL A+ C+ LL
Sbjct: 572 DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLL 628
Score = 58.5 bits (140), Expect = 1e-08
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 1/106 (0%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
++ D+ G TP AA +G + ++ + + G + D +++GNT LH A NG V+
Sbjct: 173 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNE 232
Query: 84 LVNFGANIFALDNDLQTPLD-AAASREQNECVALLDKAATAQNIMN 128
L+++GAN+ +N+ TPL AAAS C+ LL NI +
Sbjct: 233 LIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS 278
Score = 58.2 bits (139), Expect = 1e-08
Identities = 34/103 (33%), Positives = 51/103 (49%), Gaps = 1/103 (0%)
Query: 29 DEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFG 88
D+ G TP AA+ ++E L+++ + D G T L AA NG A V LVN
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 89 -ANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPK 130
A++ D DL TPL A S+ +C L+ ++++N K
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
Score = 57.8 bits (138), Expect = 2e-08
Identities = 33/97 (34%), Positives = 51/97 (52%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
+++ D+DG TP +AA +G+ + + + G D +C I PLH AA N H+ C
Sbjct: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365
Query: 84 LVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
L++ G I D +T L AAA+ EC+ LL +
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSS 402
Score = 57.4 bits (137), Expect = 2e-08
Identities = 38/115 (33%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 3 TRYHQAASDSY----LELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDP 58
T H AA+ ++ LELL D+N+ +DG +P + A HG + + GG+
Sbjct: 249 TPLHFAAASTHGALCLELLVN-NGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEI 307
Query: 59 DRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNEC 113
D D GNTPLH AA GH ++ L GA+ PL AA ++C
Sbjct: 308 DCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDC 362
Score = 57.0 bits (136), Expect = 3e-08
Identities = 28/84 (33%), Positives = 46/84 (54%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFL 84
+++ D G TP +LA +G+++A+ ++ + + D DI G T LH GH CV L
Sbjct: 638 VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQML 697
Query: 85 VNFGANIFALDNDLQTPLDAAASR 108
+ +I D+ +TPL AA+R
Sbjct: 698 LEQEVSILCKDSRGRTPLHYAAAR 721
Score = 55.8 bits (133), Expect = 7e-08
Identities = 31/86 (36%), Positives = 47/86 (54%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFL 84
+N+SD G T AA +G++E + ++ ++G + + D LH+AA GH V+ L
Sbjct: 108 VNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 167
Query: 85 VNFGANIFALDNDLQTPLDAAASREQ 110
+N GA + D TPL AAAS Q
Sbjct: 168 INHGAEVTCKDKKGYTPLHAAASNGQ 193
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/116 (28%), Positives = 57/116 (49%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
D+N D + TP +AA+ G+ E +E++ G + D TPLH A ++ V
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 84 LVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQA 139
L+ A++ A D + QTPL AA+ + +C ++ ++ N+ + T L A
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAA 123
Score = 53.1 bits (126), Expect = 4e-07
Identities = 44/149 (29%), Positives = 67/149 (44%), Gaps = 16/149 (10%)
Query: 3 TRYHQAASDSYLELLKEA-----TKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGD 57
T H AA+ + L E ++ D D G TP A Y+GN +E++ +
Sbjct: 713 TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ--- 769
Query: 58 PDRC--DIWGN--TPLHFAASNGHAHCVSFLVNF--GANIFALDNDLQTPLDAAASREQN 111
+C GN TPLH A N H +C S L+ + + D+ +TPL AAA +
Sbjct: 770 --KCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827
Query: 112 ECVALLDKAATAQNIMNPKKVTRLKEQAQ 140
EC+ LL + + N ++ T L A+
Sbjct: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAE 856
Score = 52.8 bits (125), Expect = 6e-07
Identities = 44/148 (29%), Positives = 63/148 (42%), Gaps = 2/148 (1%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H+A + E ++ K D+N D++ TP +AA + ++ E+I +
Sbjct: 51 TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
D G T LH AA NGH V+ L+ GANI A D + L AA + VALL
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIK 148
+ K T L A +K
Sbjct: 171 GAEVTCKDKKGYTPLHAAASNGQINVVK 198
Score = 52.0 bits (123), Expect = 1e-06
Identities = 39/129 (30%), Positives = 60/129 (46%), Gaps = 3/129 (2%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLSDEDGMTPTLL--AAYHGNLEALEIICSRGGDPDR 60
T H AA + ++E++ + N++ D L AAY G+L+ + ++ + G +
Sbjct: 117 TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC 176
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECV-ALLDK 119
D G TPLH AASNG + V L+N G I ++ T L A Q+ V L+D
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY 236
Query: 120 AATAQNIMN 128
A N
Sbjct: 237 GANVNQPNN 245
Score = 47.0 bits (110), Expect = 3e-05
Identities = 28/85 (32%), Positives = 42/85 (49%)
Query: 33 MTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIF 92
M P LAA + + + + S G + D D +G T LH AA+ G+ C+ L + GA+
Sbjct: 348 MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407
Query: 93 ALDNDLQTPLDAAASREQNECVALL 117
D +TPL AA+ C+ L
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETL 432
Score = 41.2 bits (95), Expect = 0.002
Identities = 29/87 (33%), Positives = 37/87 (42%)
Query: 57 DPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVAL 116
D + D TPLH AA G A + L+ GA + A DN TPL A + E V +
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 117 LDKAATAQNIMNPKKVTRLKEQAQKNA 143
L K + N + T L A A
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKA 94
Score = 39.3 bits (90), Expect = 0.007
Identities = 40/150 (26%), Positives = 59/150 (39%), Gaps = 43/150 (28%)
Query: 5 YHQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGG-------- 56
+HQA LE+L ++ DL++ DE G T LAA+ G+ E +E + + G
Sbjct: 554 HHQA-----LEVLLQSLV-DLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNV 607
Query: 57 --------------------------DPDRCDIW---GNTPLHFAASNGHAHCVSFLVNF 87
+P+ D+ G TPL A + GH VS L+
Sbjct: 608 TKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEK 667
Query: 88 GANIFALDNDLQTPLDAAASREQNECVALL 117
AN+ +D T L ECV +L
Sbjct: 668 EANVDTVDILGCTALHRGIMTGHEECVQML 697
Score = 38.5 bits (88), Expect = 0.011
Identities = 26/93 (27%), Positives = 41/93 (44%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFL 84
+N D +TP A + EA++++ D + D TPLH AA+N C +
Sbjct: 42 VNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVI 101
Query: 85 VNFGANIFALDNDLQTPLDAAASREQNECVALL 117
+ +++ D +T L AA E V LL
Sbjct: 102 IPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134
Score = 32.3 bits (72), Expect = 0.82
Identities = 38/171 (22%), Positives = 67/171 (39%), Gaps = 32/171 (18%)
Query: 3 TRYHQAASDSYLELLKE--ATKRDLNLSDEDGMTP-------------TLLAAYHGNLE- 46
T H AA++ + ++ T ++N +D+ G T T+L H N E
Sbjct: 415 TPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEE 474
Query: 47 --------------ALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIF 92
LE + +P D G +H+AA+ GH C+ L+ + F
Sbjct: 475 LERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGF 534
Query: 93 ALDND--LQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQK 141
+ ++PL AA ++ + +L ++ +I + K T L A K
Sbjct: 535 EESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFK 585
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 65.5 bits (158), Expect = 9e-11
Identities = 42/127 (33%), Positives = 63/127 (49%), Gaps = 3/127 (2%)
Query: 3 TRYHQAASDSYLELLKEATKR---DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
T QAA+ + LL D+N S EDG + AA +G+ + + ++ S +
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDK 119
D G TPL AA+ GH CV L+++ ANI + QTPL A EC+ LL +
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 120 AATAQNI 126
A T +++
Sbjct: 832 AGTNRSV 838
Score = 55.8 bits (133), Expect = 7e-08
Identities = 29/98 (29%), Positives = 48/98 (48%)
Query: 20 ATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAH 79
+ + +N +D++G TP AA G+ E +E++ S + + G TPL+ A NG+
Sbjct: 765 SAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKE 824
Query: 80 CVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
C+ L+ G N D TP+ AA + + LL
Sbjct: 825 CIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Score = 35.8 bits (81), Expect = 0.074
Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 2/80 (2%)
Query: 8 AASDSYLELLKEATKRDLNLSD--EDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWG 65
AA+ + E ++ D N++ + G TP LA +GN E ++++ G + G
Sbjct: 784 AAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDG 843
Query: 66 NTPLHFAASNGHAHCVSFLV 85
TP+H A G+ + L+
Sbjct: 844 WTPVHAAVDTGNVDSLKLLM 863
Score = 31.2 bits (69), Expect = 1.8
Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 2/61 (3%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGG-DPDRCDIWGNTPLHFAASNGHAHCVSF 83
+N ++ +G T +AA G LEI+C GG +P+R D T +H A++ H +
Sbjct: 906 INHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRT-VHDVATDDCKHLLEN 964
Query: 84 L 84
L
Sbjct: 965 L 965
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 65.1 bits (157), Expect = 1e-10
Identities = 42/122 (34%), Positives = 66/122 (54%), Gaps = 3/122 (2%)
Query: 8 AASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWG 65
AA + ++++ +R D+NLSD+ G TP ++AA G+L +E + S+G D G
Sbjct: 1111 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1170
Query: 66 NTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVA-LLDKAATAQ 124
+ L +A GH V +LV GA I D + +TPLD AA E V L++K A +
Sbjct: 1171 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1230
Query: 125 NI 126
++
Sbjct: 1231 HV 1232
Score = 47.4 bits (111), Expect = 2e-05
Identities = 29/92 (31%), Positives = 44/92 (47%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G+ P AA G+ + + ++ RG D + D G TPL AA GH V FL++ GA +
Sbjct: 1104 GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAL 1163
Query: 92 FALDNDLQTPLDAAASREQNECVALLDKAATA 123
+LD + + L A + V L + A
Sbjct: 1164 SSLDKEGLSALSWACLKGHRAVVQYLVEEGAA 1195
Score = 42.4 bits (98), Expect = 8e-04
Identities = 32/117 (27%), Positives = 47/117 (40%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G T AA G LE E++ G R + G PL AA GH V L+ G ++
Sbjct: 1071 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDV 1130
Query: 92 FALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNARRQIK 148
D +TPL AA V L A + ++ + ++ L K R ++
Sbjct: 1131 NLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQ 1187
Score = 29.6 bits (65), Expect = 5.3
Identities = 23/92 (25%), Positives = 42/92 (45%), Gaps = 2/92 (2%)
Query: 41 YHGNLEALEIICSRGGDPD-RCDIWGNTPLHFAASN-GHAHCVSFLVNFGANIFALDNDL 98
Y N++ ++ G + + R ++ N P+ S+ GH V+ L+ FGA + +
Sbjct: 901 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960
Query: 99 QTPLDAAASREQNECVALLDKAATAQNIMNPK 130
T L AA+ + V LL K + ++ K
Sbjct: 961 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKK 992
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 65.1 bits (157), Expect = 1e-10
Identities = 42/122 (34%), Positives = 66/122 (54%), Gaps = 3/122 (2%)
Query: 8 AASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWG 65
AA + ++++ +R D+NLSD+ G TP ++AA G+L +E + S+G D G
Sbjct: 1119 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1178
Query: 66 NTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVA-LLDKAATAQ 124
+ L +A GH V +LV GA I D + +TPLD AA E V L++K A +
Sbjct: 1179 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1238
Query: 125 NI 126
++
Sbjct: 1239 HV 1240
Score = 47.4 bits (111), Expect = 2e-05
Identities = 29/92 (31%), Positives = 44/92 (47%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G+ P AA G+ + + ++ RG D + D G TPL AA GH V FL++ GA +
Sbjct: 1112 GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAL 1171
Query: 92 FALDNDLQTPLDAAASREQNECVALLDKAATA 123
+LD + + L A + V L + A
Sbjct: 1172 SSLDKEGLSALSWACLKGHRAVVQYLVEEGAA 1203
Score = 42.4 bits (98), Expect = 8e-04
Identities = 32/117 (27%), Positives = 47/117 (40%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G T AA G LE E++ G R + G PL AA GH V L+ G ++
Sbjct: 1079 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDV 1138
Query: 92 FALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNARRQIK 148
D +TPL AA V L A + ++ + ++ L K R ++
Sbjct: 1139 NLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQ 1195
Score = 29.6 bits (65), Expect = 5.3
Identities = 23/92 (25%), Positives = 42/92 (45%), Gaps = 2/92 (2%)
Query: 41 YHGNLEALEIICSRGGDPD-RCDIWGNTPLHFAASN-GHAHCVSFLVNFGANIFALDNDL 98
Y N++ ++ G + + R ++ N P+ S+ GH V+ L+ FGA + +
Sbjct: 909 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 968
Query: 99 QTPLDAAASREQNECVALLDKAATAQNIMNPK 130
T L AA+ + V LL K + ++ K
Sbjct: 969 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKK 1000
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 63.2 bits (152), Expect = 4e-10
Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 2/141 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDL--NLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + + + +RD N + ++G+TP +A +H NL+ ++++ RGG P
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH AA L+ +G + A TPL AA E VALL
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 690
Query: 121 ATAQNIMNPKKVTRLKEQAQK 141
N+ N +T L AQ+
Sbjct: 691 QANGNLGNKSGLTPLHLVAQE 711
Score = 58.9 bits (141), Expect = 8e-09
Identities = 48/178 (26%), Positives = 73/178 (41%), Gaps = 16/178 (8%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H A +++ +++ K ++ E G+TP +A++ G+L ++ + RG P+
Sbjct: 406 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
++ TPLH AA GH +L+ A + A D QTPL AA V LL
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL--- 522
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKG 178
+N NP T A R E H + KE S + KG
Sbjct: 523 --LENNANPNLATTAGHTPLHIAAR---------EGHVETVLALLEKEASQACMTKKG 569
Score = 57.0 bits (136), Expect = 3e-08
Identities = 38/137 (27%), Positives = 63/137 (45%), Gaps = 2/137 (1%)
Query: 6 HQAASDSYLELLKEATKRDLNLSDE--DGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H AA +L+ ++ + D + D D +TP +AA+ G+ +++ +G P+ +
Sbjct: 343 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 402
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G TPLH A H + L+ GA+I A+ TPL A+ V L + +
Sbjct: 403 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 462
Query: 124 QNIMNPKKVTRLKEQAQ 140
N+ N K T L A+
Sbjct: 463 PNVSNVKVETPLHMAAR 479
Score = 55.5 bits (132), Expect = 9e-08
Identities = 38/135 (28%), Positives = 62/135 (45%), Gaps = 2/135 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDLN--LSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + + E++ + N L ++ G+TP L A G++ +++ G D
Sbjct: 670 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 729
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH A+ G+ V FL+ A++ A +PL AA + + V LL K
Sbjct: 730 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 789
Query: 121 ATAQNIMNPKKVTRL 135
+ N ++ T L
Sbjct: 790 GASPNEVSSDGTTPL 804
Score = 53.9 bits (128), Expect = 3e-07
Identities = 36/117 (30%), Positives = 57/117 (48%), Gaps = 2/117 (1%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA L + + R +N + ++G+TP +A+ GN+ + ++ RG +
Sbjct: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 300
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
TPLH AA NGH L++ GA I A + +P+ AA + +CV LL
Sbjct: 301 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
Score = 51.6 bits (122), Expect = 1e-06
Identities = 45/178 (25%), Positives = 76/178 (42%), Gaps = 16/178 (8%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + ++E + +++ + + + G TP +AA +G + E++ R P+
Sbjct: 538 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 597
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH A + + V L+ G + + + TPL AA + Q E L +
Sbjct: 598 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 657
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKG 178
+ N + + VT L A QE H +A SK+ +G L + G
Sbjct: 658 GGSANAESVQGVTPLHLAA--------------QEGHAEMVALLLSKQANGNLGNKSG 701
Score = 50.1 bits (118), Expect = 4e-06
Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 14/140 (10%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
D+N +++G+ LA+ G+++ + + + + GNT LH AA G V
Sbjct: 70 DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRE 129
Query: 84 LVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNA 143
LVN+GAN+ A TPL AA E V L + QN+ T L
Sbjct: 130 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL-------- 181
Query: 144 RRQIKECERLQEKHQNKMAH 163
LQ+ H+N +AH
Sbjct: 182 ------AVALQQGHENVVAH 195
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/144 (26%), Positives = 57/144 (39%), Gaps = 2/144 (1%)
Query: 1 MSTRYHQAASDSYLELLKEA--TKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDP 58
+ T H AA + E+ K K +N +D TP AA G+ ++++ +P
Sbjct: 470 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529
Query: 59 DRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLD 118
+ G+TPLH AA GH V L+ A+ + TPL AA + LL
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589
Query: 119 KAATAQNIMNPKKVTRLKEQAQKN 142
+ N +T L N
Sbjct: 590 ERDAHPNAAGKNGLTPLHVAVHHN 613
Score = 47.4 bits (111), Expect = 2e-05
Identities = 27/75 (36%), Positives = 39/75 (52%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G TP +AA++ NL +++ +RG + G TPLH A+ G+ V L++ GA I
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 298
Query: 92 FALDNDLQTPLDAAA 106
D TPL AA
Sbjct: 299 ETKTKDELTPLHCAA 313
Score = 46.6 bits (109), Expect = 4e-05
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 1/93 (1%)
Query: 30 EDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGA 89
+D +TP AA +G++ EI+ G G +P+H AA H CV L+ + A
Sbjct: 303 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 362
Query: 90 NIFALDNDLQTPLDAAASREQNECV-ALLDKAA 121
I + D TPL AA + LLDK A
Sbjct: 363 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 395
Score = 46.2 bits (108), Expect = 5e-05
Identities = 35/135 (25%), Positives = 60/135 (44%), Gaps = 11/135 (8%)
Query: 2 STRYHQAASDSYLELLKEATK--RDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
+T H AA E+++E ++N + G TP +AA +LE ++ + G + +
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 171
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDK 119
G TPL A GH + V+ L+N+G ++ P A+R + A
Sbjct: 172 VATEDGFTPLAVALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTA---- 222
Query: 120 AATAQNIMNPKKVTR 134
A QN NP +++
Sbjct: 223 AVLLQNDPNPDVLSK 237
Score = 45.8 bits (107), Expect = 7e-05
Identities = 34/126 (26%), Positives = 56/126 (44%), Gaps = 2/126 (1%)
Query: 6 HQAASDSYLELLKEATKRDLNL--SDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H A+ + +++++ E +++ L + + G T +AA G E + + + G + +
Sbjct: 83 HLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQ 142
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G TPL+ AA H V FL+ GAN D TPL A + VA L T
Sbjct: 143 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 202
Query: 124 QNIMNP 129
+ P
Sbjct: 203 GKVRLP 208
Score = 45.8 bits (107), Expect = 7e-05
Identities = 30/106 (28%), Positives = 47/106 (44%), Gaps = 2/106 (1%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + +E+ + + N G+TP LAA G+ E + ++ S+ + +
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 696
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAA 106
+ G TPLH A GH L+ G + A TPL A+
Sbjct: 697 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742
Score = 45.1 bits (105), Expect = 1e-04
Identities = 24/74 (32%), Positives = 40/74 (54%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G TP +A+++GN++ ++ + D + G +PLH AA GH V+ L+ GA+
Sbjct: 734 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 793
Query: 92 FALDNDLQTPLDAA 105
+ +D TPL A
Sbjct: 794 NEVSSDGTTPLAIA 807
Score = 41.6 bits (96), Expect = 0.001
Identities = 26/87 (29%), Positives = 39/87 (44%)
Query: 31 DGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGAN 90
+G TP +A ++ +E++ G D G TPLH A+ GH V L+ GA+
Sbjct: 403 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 462
Query: 91 IFALDNDLQTPLDAAASREQNECVALL 117
+ ++TPL AA E L
Sbjct: 463 PNVSNVKVETPLHMAARAGHTEVAKYL 489
Score = 39.3 bits (90), Expect = 0.007
Identities = 39/146 (26%), Positives = 60/146 (41%), Gaps = 31/146 (21%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGN---------------- 44
T + AA +++LE++K + + N++ EDG TP +A G+
Sbjct: 146 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 205
Query: 45 -LEALEI------------ICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
L AL I + +PD G TPLH AA + + L+N GA++
Sbjct: 206 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 265
Query: 92 FALDNDLQTPLDAAASREQNECVALL 117
+ TPL A+ R V LL
Sbjct: 266 NFTPQNGITPLHIASRRGNVIMVRLL 291
Score = 38.1 bits (87), Expect = 0.015
Identities = 35/118 (29%), Positives = 46/118 (38%)
Query: 31 DGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGAN 90
D T L AA GNL+ G D + C+ G LH A+ GH V L++
Sbjct: 44 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 103
Query: 91 IFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNARRQIK 148
+ T L AA Q+E V L N + K T L AQ+N +K
Sbjct: 104 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 161
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 63.2 bits (152), Expect = 4e-10
Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 2/141 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDL--NLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + + + +RD N + ++G+TP +A +H NL+ ++++ RGG P
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH AA L+ +G + A TPL AA E VALL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 121 ATAQNIMNPKKVTRLKEQAQK 141
N+ N +T L AQ+
Sbjct: 658 QANGNLGNKSGLTPLHLVAQE 678
Score = 58.9 bits (141), Expect = 8e-09
Identities = 48/178 (26%), Positives = 73/178 (41%), Gaps = 16/178 (8%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H A +++ +++ K ++ E G+TP +A++ G+L ++ + RG P+
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
++ TPLH AA GH +L+ A + A D QTPL AA V LL
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL--- 489
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKG 178
+N NP T A R E H + KE S + KG
Sbjct: 490 --LENNANPNLATTAGHTPLHIAAR---------EGHVETVLALLEKEASQACMTKKG 536
Score = 57.0 bits (136), Expect = 3e-08
Identities = 38/137 (27%), Positives = 63/137 (45%), Gaps = 2/137 (1%)
Query: 6 HQAASDSYLELLKEATKRDLNLSDE--DGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H AA +L+ ++ + D + D D +TP +AA+ G+ +++ +G P+ +
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G TPLH A H + L+ GA+I A+ TPL A+ V L + +
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 124 QNIMNPKKVTRLKEQAQ 140
N+ N K T L A+
Sbjct: 430 PNVSNVKVETPLHMAAR 446
Score = 55.5 bits (132), Expect = 9e-08
Identities = 38/135 (28%), Positives = 62/135 (45%), Gaps = 2/135 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDLN--LSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + + E++ + N L ++ G+TP L A G++ +++ G D
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH A+ G+ V FL+ A++ A +PL AA + + V LL K
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 121 ATAQNIMNPKKVTRL 135
+ N ++ T L
Sbjct: 757 GASPNEVSSDGTTPL 771
Score = 53.9 bits (128), Expect = 3e-07
Identities = 36/117 (30%), Positives = 57/117 (48%), Gaps = 2/117 (1%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA L + + R +N + ++G+TP +A+ GN+ + ++ RG +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
TPLH AA NGH L++ GA I A + +P+ AA + +CV LL
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 51.6 bits (122), Expect = 1e-06
Identities = 45/178 (25%), Positives = 76/178 (42%), Gaps = 16/178 (8%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + ++E + +++ + + + G TP +AA +G + E++ R P+
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH A + + V L+ G + + + TPL AA + Q E L +
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKG 178
+ N + + VT L A QE H +A SK+ +G L + G
Sbjct: 625 GGSANAESVQGVTPLHLAA--------------QEGHAEMVALLLSKQANGNLGNKSG 668
Score = 50.1 bits (118), Expect = 4e-06
Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 14/140 (10%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
D+N +++G+ LA+ G+++ + + + + GNT LH AA G V
Sbjct: 37 DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRE 96
Query: 84 LVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNA 143
LVN+GAN+ A TPL AA E V L + QN+ T L
Sbjct: 97 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL-------- 148
Query: 144 RRQIKECERLQEKHQNKMAH 163
LQ+ H+N +AH
Sbjct: 149 ------AVALQQGHENVVAH 162
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/144 (26%), Positives = 57/144 (39%), Gaps = 2/144 (1%)
Query: 1 MSTRYHQAASDSYLELLKEA--TKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDP 58
+ T H AA + E+ K K +N +D TP AA G+ ++++ +P
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 59 DRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLD 118
+ G+TPLH AA GH V L+ A+ + TPL AA + LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 119 KAATAQNIMNPKKVTRLKEQAQKN 142
+ N +T L N
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHN 580
Score = 47.4 bits (111), Expect = 2e-05
Identities = 27/75 (36%), Positives = 39/75 (52%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G TP +AA++ NL +++ +RG + G TPLH A+ G+ V L++ GA I
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 92 FALDNDLQTPLDAAA 106
D TPL AA
Sbjct: 266 ETKTKDELTPLHCAA 280
Score = 46.6 bits (109), Expect = 4e-05
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 1/93 (1%)
Query: 30 EDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGA 89
+D +TP AA +G++ EI+ G G +P+H AA H CV L+ + A
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
Query: 90 NIFALDNDLQTPLDAAASREQNECV-ALLDKAA 121
I + D TPL AA + LLDK A
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Score = 46.2 bits (108), Expect = 5e-05
Identities = 35/135 (25%), Positives = 60/135 (44%), Gaps = 11/135 (8%)
Query: 2 STRYHQAASDSYLELLKEATK--RDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
+T H AA E+++E ++N + G TP +AA +LE ++ + G + +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDK 119
G TPL A GH + V+ L+N+G ++ P A+R + A
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTA---- 189
Query: 120 AATAQNIMNPKKVTR 134
A QN NP +++
Sbjct: 190 AVLLQNDPNPDVLSK 204
Score = 45.8 bits (107), Expect = 7e-05
Identities = 34/126 (26%), Positives = 56/126 (44%), Gaps = 2/126 (1%)
Query: 6 HQAASDSYLELLKEATKRDLNL--SDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H A+ + +++++ E +++ L + + G T +AA G E + + + G + +
Sbjct: 50 HLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQ 109
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G TPL+ AA H V FL+ GAN D TPL A + VA L T
Sbjct: 110 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169
Query: 124 QNIMNP 129
+ P
Sbjct: 170 GKVRLP 175
Score = 45.8 bits (107), Expect = 7e-05
Identities = 30/106 (28%), Positives = 47/106 (44%), Gaps = 2/106 (1%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + +E+ + + N G+TP LAA G+ E + ++ S+ + +
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAA 106
+ G TPLH A GH L+ G + A TPL A+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 45.1 bits (105), Expect = 1e-04
Identities = 24/74 (32%), Positives = 40/74 (54%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G TP +A+++GN++ ++ + D + G +PLH AA GH V+ L+ GA+
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 92 FALDNDLQTPLDAA 105
+ +D TPL A
Sbjct: 761 NEVSSDGTTPLAIA 774
Score = 41.6 bits (96), Expect = 0.001
Identities = 26/87 (29%), Positives = 39/87 (44%)
Query: 31 DGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGAN 90
+G TP +A ++ +E++ G D G TPLH A+ GH V L+ GA+
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 91 IFALDNDLQTPLDAAASREQNECVALL 117
+ ++TPL AA E L
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 39.3 bits (90), Expect = 0.007
Identities = 39/146 (26%), Positives = 60/146 (41%), Gaps = 31/146 (21%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGN---------------- 44
T + AA +++LE++K + + N++ EDG TP +A G+
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 45 -LEALEI------------ICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
L AL I + +PD G TPLH AA + + L+N GA++
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 92 FALDNDLQTPLDAAASREQNECVALL 117
+ TPL A+ R V LL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 38.5 bits (88), Expect = 0.011
Identities = 35/120 (29%), Positives = 47/120 (39%)
Query: 29 DEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFG 88
+ D T L AA GNL+ G D + C+ G LH A+ GH V L++
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 89 ANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNARRQIK 148
+ T L AA Q+E V L N + K T L AQ+N +K
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 63.2 bits (152), Expect = 4e-10
Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 2/141 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDL--NLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + + + +RD N + ++G+TP +A +H NL+ ++++ RGG P
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH AA L+ +G + A TPL AA E VALL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 121 ATAQNIMNPKKVTRLKEQAQK 141
N+ N +T L AQ+
Sbjct: 658 QANGNLGNKSGLTPLHLVAQE 678
Score = 58.9 bits (141), Expect = 8e-09
Identities = 48/178 (26%), Positives = 73/178 (41%), Gaps = 16/178 (8%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H A +++ +++ K ++ E G+TP +A++ G+L ++ + RG P+
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
++ TPLH AA GH +L+ A + A D QTPL AA V LL
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL--- 489
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKG 178
+N NP T A R E H + KE S + KG
Sbjct: 490 --LENNANPNLATTAGHTPLHIAAR---------EGHVETVLALLEKEASQACMTKKG 536
Score = 57.0 bits (136), Expect = 3e-08
Identities = 38/137 (27%), Positives = 63/137 (45%), Gaps = 2/137 (1%)
Query: 6 HQAASDSYLELLKEATKRDLNLSDE--DGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H AA +L+ ++ + D + D D +TP +AA+ G+ +++ +G P+ +
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G TPLH A H + L+ GA+I A+ TPL A+ V L + +
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 124 QNIMNPKKVTRLKEQAQ 140
N+ N K T L A+
Sbjct: 430 PNVSNVKVETPLHMAAR 446
Score = 55.5 bits (132), Expect = 9e-08
Identities = 38/135 (28%), Positives = 62/135 (45%), Gaps = 2/135 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDLN--LSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + + E++ + N L ++ G+TP L A G++ +++ G D
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH A+ G+ V FL+ A++ A +PL AA + + V LL K
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 121 ATAQNIMNPKKVTRL 135
+ N ++ T L
Sbjct: 757 GASPNEVSSDGTTPL 771
Score = 53.9 bits (128), Expect = 3e-07
Identities = 36/117 (30%), Positives = 57/117 (48%), Gaps = 2/117 (1%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA L + + R +N + ++G+TP +A+ GN+ + ++ RG +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
TPLH AA NGH L++ GA I A + +P+ AA + +CV LL
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 51.6 bits (122), Expect = 1e-06
Identities = 45/178 (25%), Positives = 76/178 (42%), Gaps = 16/178 (8%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + ++E + +++ + + + G TP +AA +G + E++ R P+
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH A + + V L+ G + + + TPL AA + Q E L +
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKG 178
+ N + + VT L A QE H +A SK+ +G L + G
Sbjct: 625 GGSANAESVQGVTPLHLAA--------------QEGHAEMVALLLSKQANGNLGNKSG 668
Score = 50.1 bits (118), Expect = 4e-06
Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 14/140 (10%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
D+N +++G+ LA+ G+++ + + + + GNT LH AA G V
Sbjct: 37 DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRE 96
Query: 84 LVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNA 143
LVN+GAN+ A TPL AA E V L + QN+ T L
Sbjct: 97 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL-------- 148
Query: 144 RRQIKECERLQEKHQNKMAH 163
LQ+ H+N +AH
Sbjct: 149 ------AVALQQGHENVVAH 162
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/144 (26%), Positives = 57/144 (39%), Gaps = 2/144 (1%)
Query: 1 MSTRYHQAASDSYLELLKEA--TKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDP 58
+ T H AA + E+ K K +N +D TP AA G+ ++++ +P
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 59 DRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLD 118
+ G+TPLH AA GH V L+ A+ + TPL AA + LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 119 KAATAQNIMNPKKVTRLKEQAQKN 142
+ N +T L N
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHN 580
Score = 47.4 bits (111), Expect = 2e-05
Identities = 27/75 (36%), Positives = 39/75 (52%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G TP +AA++ NL +++ +RG + G TPLH A+ G+ V L++ GA I
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 92 FALDNDLQTPLDAAA 106
D TPL AA
Sbjct: 266 ETKTKDELTPLHCAA 280
Score = 46.6 bits (109), Expect = 4e-05
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 1/93 (1%)
Query: 30 EDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGA 89
+D +TP AA +G++ EI+ G G +P+H AA H CV L+ + A
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
Query: 90 NIFALDNDLQTPLDAAASREQNECV-ALLDKAA 121
I + D TPL AA + LLDK A
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Score = 46.2 bits (108), Expect = 5e-05
Identities = 35/135 (25%), Positives = 60/135 (44%), Gaps = 11/135 (8%)
Query: 2 STRYHQAASDSYLELLKEATK--RDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
+T H AA E+++E ++N + G TP +AA +LE ++ + G + +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDK 119
G TPL A GH + V+ L+N+G ++ P A+R + A
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTA---- 189
Query: 120 AATAQNIMNPKKVTR 134
A QN NP +++
Sbjct: 190 AVLLQNDPNPDVLSK 204
Score = 45.8 bits (107), Expect = 7e-05
Identities = 34/126 (26%), Positives = 56/126 (44%), Gaps = 2/126 (1%)
Query: 6 HQAASDSYLELLKEATKRDLNL--SDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H A+ + +++++ E +++ L + + G T +AA G E + + + G + +
Sbjct: 50 HLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQ 109
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G TPL+ AA H V FL+ GAN D TPL A + VA L T
Sbjct: 110 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169
Query: 124 QNIMNP 129
+ P
Sbjct: 170 GKVRLP 175
Score = 45.8 bits (107), Expect = 7e-05
Identities = 30/106 (28%), Positives = 47/106 (44%), Gaps = 2/106 (1%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + +E+ + + N G+TP LAA G+ E + ++ S+ + +
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAA 106
+ G TPLH A GH L+ G + A TPL A+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 45.1 bits (105), Expect = 1e-04
Identities = 24/74 (32%), Positives = 40/74 (54%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G TP +A+++GN++ ++ + D + G +PLH AA GH V+ L+ GA+
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 92 FALDNDLQTPLDAA 105
+ +D TPL A
Sbjct: 761 NEVSSDGTTPLAIA 774
Score = 41.6 bits (96), Expect = 0.001
Identities = 26/87 (29%), Positives = 39/87 (44%)
Query: 31 DGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGAN 90
+G TP +A ++ +E++ G D G TPLH A+ GH V L+ GA+
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 91 IFALDNDLQTPLDAAASREQNECVALL 117
+ ++TPL AA E L
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 39.3 bits (90), Expect = 0.007
Identities = 39/146 (26%), Positives = 60/146 (41%), Gaps = 31/146 (21%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGN---------------- 44
T + AA +++LE++K + + N++ EDG TP +A G+
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 45 -LEALEI------------ICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
L AL I + +PD G TPLH AA + + L+N GA++
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 92 FALDNDLQTPLDAAASREQNECVALL 117
+ TPL A+ R V LL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 38.5 bits (88), Expect = 0.011
Identities = 35/120 (29%), Positives = 47/120 (39%)
Query: 29 DEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFG 88
+ D T L AA GNL+ G D + C+ G LH A+ GH V L++
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 89 ANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNARRQIK 148
+ T L AA Q+E V L N + K T L AQ+N +K
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 63.2 bits (152), Expect = 4e-10
Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 2/141 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDL--NLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + + + +RD N + ++G+TP +A +H NL+ ++++ RGG P
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH AA L+ +G + A TPL AA E VALL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 121 ATAQNIMNPKKVTRLKEQAQK 141
N+ N +T L AQ+
Sbjct: 658 QANGNLGNKSGLTPLHLVAQE 678
Score = 58.9 bits (141), Expect = 8e-09
Identities = 48/178 (26%), Positives = 73/178 (41%), Gaps = 16/178 (8%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H A +++ +++ K ++ E G+TP +A++ G+L ++ + RG P+
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
++ TPLH AA GH +L+ A + A D QTPL AA V LL
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL--- 489
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKG 178
+N NP T A R E H + KE S + KG
Sbjct: 490 --LENNANPNLATTAGHTPLHIAAR---------EGHVETVLALLEKEASQACMTKKG 536
Score = 57.0 bits (136), Expect = 3e-08
Identities = 38/137 (27%), Positives = 63/137 (45%), Gaps = 2/137 (1%)
Query: 6 HQAASDSYLELLKEATKRDLNLSDE--DGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H AA +L+ ++ + D + D D +TP +AA+ G+ +++ +G P+ +
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G TPLH A H + L+ GA+I A+ TPL A+ V L + +
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 124 QNIMNPKKVTRLKEQAQ 140
N+ N K T L A+
Sbjct: 430 PNVSNVKVETPLHMAAR 446
Score = 55.5 bits (132), Expect = 9e-08
Identities = 38/135 (28%), Positives = 62/135 (45%), Gaps = 2/135 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDLN--LSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + + E++ + N L ++ G+TP L A G++ +++ G D
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH A+ G+ V FL+ A++ A +PL AA + + V LL K
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 121 ATAQNIMNPKKVTRL 135
+ N ++ T L
Sbjct: 757 GASPNEVSSDGTTPL 771
Score = 53.9 bits (128), Expect = 3e-07
Identities = 36/117 (30%), Positives = 57/117 (48%), Gaps = 2/117 (1%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA L + + R +N + ++G+TP +A+ GN+ + ++ RG +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
TPLH AA NGH L++ GA I A + +P+ AA + +CV LL
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 51.6 bits (122), Expect = 1e-06
Identities = 45/178 (25%), Positives = 76/178 (42%), Gaps = 16/178 (8%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + ++E + +++ + + + G TP +AA +G + E++ R P+
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH A + + V L+ G + + + TPL AA + Q E L +
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKG 178
+ N + + VT L A QE H +A SK+ +G L + G
Sbjct: 625 GGSANAESVQGVTPLHLAA--------------QEGHAEMVALLLSKQANGNLGNKSG 668
Score = 50.1 bits (118), Expect = 4e-06
Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 14/140 (10%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
D+N +++G+ LA+ G+++ + + + + GNT LH AA G V
Sbjct: 37 DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRE 96
Query: 84 LVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNA 143
LVN+GAN+ A TPL AA E V L + QN+ T L
Sbjct: 97 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL-------- 148
Query: 144 RRQIKECERLQEKHQNKMAH 163
LQ+ H+N +AH
Sbjct: 149 ------AVALQQGHENVVAH 162
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/144 (26%), Positives = 57/144 (39%), Gaps = 2/144 (1%)
Query: 1 MSTRYHQAASDSYLELLKEA--TKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDP 58
+ T H AA + E+ K K +N +D TP AA G+ ++++ +P
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 59 DRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLD 118
+ G+TPLH AA GH V L+ A+ + TPL AA + LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 119 KAATAQNIMNPKKVTRLKEQAQKN 142
+ N +T L N
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHN 580
Score = 47.4 bits (111), Expect = 2e-05
Identities = 27/75 (36%), Positives = 39/75 (52%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G TP +AA++ NL +++ +RG + G TPLH A+ G+ V L++ GA I
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 92 FALDNDLQTPLDAAA 106
D TPL AA
Sbjct: 266 ETKTKDELTPLHCAA 280
Score = 46.6 bits (109), Expect = 4e-05
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 1/93 (1%)
Query: 30 EDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGA 89
+D +TP AA +G++ EI+ G G +P+H AA H CV L+ + A
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
Query: 90 NIFALDNDLQTPLDAAASREQNECV-ALLDKAA 121
I + D TPL AA + LLDK A
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Score = 46.2 bits (108), Expect = 5e-05
Identities = 35/135 (25%), Positives = 60/135 (44%), Gaps = 11/135 (8%)
Query: 2 STRYHQAASDSYLELLKEATK--RDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
+T H AA E+++E ++N + G TP +AA +LE ++ + G + +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDK 119
G TPL A GH + V+ L+N+G ++ P A+R + A
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTA---- 189
Query: 120 AATAQNIMNPKKVTR 134
A QN NP +++
Sbjct: 190 AVLLQNDPNPDVLSK 204
Score = 45.8 bits (107), Expect = 7e-05
Identities = 34/126 (26%), Positives = 56/126 (44%), Gaps = 2/126 (1%)
Query: 6 HQAASDSYLELLKEATKRDLNL--SDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H A+ + +++++ E +++ L + + G T +AA G E + + + G + +
Sbjct: 50 HLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQ 109
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G TPL+ AA H V FL+ GAN D TPL A + VA L T
Sbjct: 110 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169
Query: 124 QNIMNP 129
+ P
Sbjct: 170 GKVRLP 175
Score = 45.8 bits (107), Expect = 7e-05
Identities = 30/106 (28%), Positives = 47/106 (44%), Gaps = 2/106 (1%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + +E+ + + N G+TP LAA G+ E + ++ S+ + +
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAA 106
+ G TPLH A GH L+ G + A TPL A+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 45.1 bits (105), Expect = 1e-04
Identities = 24/74 (32%), Positives = 40/74 (54%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G TP +A+++GN++ ++ + D + G +PLH AA GH V+ L+ GA+
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 92 FALDNDLQTPLDAA 105
+ +D TPL A
Sbjct: 761 NEVSSDGTTPLAIA 774
Score = 41.6 bits (96), Expect = 0.001
Identities = 26/87 (29%), Positives = 39/87 (44%)
Query: 31 DGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGAN 90
+G TP +A ++ +E++ G D G TPLH A+ GH V L+ GA+
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 91 IFALDNDLQTPLDAAASREQNECVALL 117
+ ++TPL AA E L
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 39.3 bits (90), Expect = 0.007
Identities = 39/146 (26%), Positives = 60/146 (41%), Gaps = 31/146 (21%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGN---------------- 44
T + AA +++LE++K + + N++ EDG TP +A G+
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 45 -LEALEI------------ICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
L AL I + +PD G TPLH AA + + L+N GA++
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 92 FALDNDLQTPLDAAASREQNECVALL 117
+ TPL A+ R V LL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 38.5 bits (88), Expect = 0.011
Identities = 35/120 (29%), Positives = 47/120 (39%)
Query: 29 DEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFG 88
+ D T L AA GNL+ G D + C+ G LH A+ GH V L++
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 89 ANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNARRQIK 148
+ T L AA Q+E V L N + K T L AQ+N +K
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 63.2 bits (152), Expect = 4e-10
Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 2/141 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDL--NLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + + + +RD N + ++G+TP +A +H NL+ ++++ RGG P
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH AA L+ +G + A TPL AA E VALL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 121 ATAQNIMNPKKVTRLKEQAQK 141
N+ N +T L AQ+
Sbjct: 658 QANGNLGNKSGLTPLHLVAQE 678
Score = 58.9 bits (141), Expect = 8e-09
Identities = 48/178 (26%), Positives = 73/178 (41%), Gaps = 16/178 (8%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H A +++ +++ K ++ E G+TP +A++ G+L ++ + RG P+
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
++ TPLH AA GH +L+ A + A D QTPL AA V LL
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL--- 489
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKG 178
+N NP T A R E H + KE S + KG
Sbjct: 490 --LENNANPNLATTAGHTPLHIAAR---------EGHVETVLALLEKEASQACMTKKG 536
Score = 57.0 bits (136), Expect = 3e-08
Identities = 38/137 (27%), Positives = 63/137 (45%), Gaps = 2/137 (1%)
Query: 6 HQAASDSYLELLKEATKRDLNLSDE--DGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H AA +L+ ++ + D + D D +TP +AA+ G+ +++ +G P+ +
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G TPLH A H + L+ GA+I A+ TPL A+ V L + +
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 124 QNIMNPKKVTRLKEQAQ 140
N+ N K T L A+
Sbjct: 430 PNVSNVKVETPLHMAAR 446
Score = 55.5 bits (132), Expect = 9e-08
Identities = 38/135 (28%), Positives = 62/135 (45%), Gaps = 2/135 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDLN--LSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + + E++ + N L ++ G+TP L A G++ +++ G D
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH A+ G+ V FL+ A++ A +PL AA + + V LL K
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 121 ATAQNIMNPKKVTRL 135
+ N ++ T L
Sbjct: 757 GASPNEVSSDGTTPL 771
Score = 53.9 bits (128), Expect = 3e-07
Identities = 36/117 (30%), Positives = 57/117 (48%), Gaps = 2/117 (1%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA L + + R +N + ++G+TP +A+ GN+ + ++ RG +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
TPLH AA NGH L++ GA I A + +P+ AA + +CV LL
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 51.6 bits (122), Expect = 1e-06
Identities = 45/178 (25%), Positives = 76/178 (42%), Gaps = 16/178 (8%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + ++E + +++ + + + G TP +AA +G + E++ R P+
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH A + + V L+ G + + + TPL AA + Q E L +
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKG 178
+ N + + VT L A QE H +A SK+ +G L + G
Sbjct: 625 GGSANAESVQGVTPLHLAA--------------QEGHAEMVALLLSKQANGNLGNKSG 668
Score = 50.1 bits (118), Expect = 4e-06
Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 14/140 (10%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
D+N +++G+ LA+ G+++ + + + + GNT LH AA G V
Sbjct: 37 DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRE 96
Query: 84 LVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNA 143
LVN+GAN+ A TPL AA E V L + QN+ T L
Sbjct: 97 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL-------- 148
Query: 144 RRQIKECERLQEKHQNKMAH 163
LQ+ H+N +AH
Sbjct: 149 ------AVALQQGHENVVAH 162
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/144 (26%), Positives = 57/144 (39%), Gaps = 2/144 (1%)
Query: 1 MSTRYHQAASDSYLELLKEA--TKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDP 58
+ T H AA + E+ K K +N +D TP AA G+ ++++ +P
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 59 DRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLD 118
+ G+TPLH AA GH V L+ A+ + TPL AA + LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 119 KAATAQNIMNPKKVTRLKEQAQKN 142
+ N +T L N
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHN 580
Score = 47.4 bits (111), Expect = 2e-05
Identities = 27/75 (36%), Positives = 39/75 (52%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G TP +AA++ NL +++ +RG + G TPLH A+ G+ V L++ GA I
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 92 FALDNDLQTPLDAAA 106
D TPL AA
Sbjct: 266 ETKTKDELTPLHCAA 280
Score = 46.6 bits (109), Expect = 4e-05
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 1/93 (1%)
Query: 30 EDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGA 89
+D +TP AA +G++ EI+ G G +P+H AA H CV L+ + A
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
Query: 90 NIFALDNDLQTPLDAAASREQNECV-ALLDKAA 121
I + D TPL AA + LLDK A
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Score = 46.2 bits (108), Expect = 5e-05
Identities = 35/135 (25%), Positives = 60/135 (44%), Gaps = 11/135 (8%)
Query: 2 STRYHQAASDSYLELLKEATK--RDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
+T H AA E+++E ++N + G TP +AA +LE ++ + G + +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDK 119
G TPL A GH + V+ L+N+G ++ P A+R + A
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTA---- 189
Query: 120 AATAQNIMNPKKVTR 134
A QN NP +++
Sbjct: 190 AVLLQNDPNPDVLSK 204
Score = 45.8 bits (107), Expect = 7e-05
Identities = 34/126 (26%), Positives = 56/126 (44%), Gaps = 2/126 (1%)
Query: 6 HQAASDSYLELLKEATKRDLNL--SDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H A+ + +++++ E +++ L + + G T +AA G E + + + G + +
Sbjct: 50 HLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQ 109
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G TPL+ AA H V FL+ GAN D TPL A + VA L T
Sbjct: 110 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169
Query: 124 QNIMNP 129
+ P
Sbjct: 170 GKVRLP 175
Score = 45.8 bits (107), Expect = 7e-05
Identities = 30/106 (28%), Positives = 47/106 (44%), Gaps = 2/106 (1%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + +E+ + + N G+TP LAA G+ E + ++ S+ + +
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAA 106
+ G TPLH A GH L+ G + A TPL A+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 45.1 bits (105), Expect = 1e-04
Identities = 24/74 (32%), Positives = 40/74 (54%)
Query: 32 GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
G TP +A+++GN++ ++ + D + G +PLH AA GH V+ L+ GA+
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 92 FALDNDLQTPLDAA 105
+ +D TPL A
Sbjct: 761 NEVSSDGTTPLAIA 774
Score = 41.6 bits (96), Expect = 0.001
Identities = 26/87 (29%), Positives = 39/87 (44%)
Query: 31 DGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGAN 90
+G TP +A ++ +E++ G D G TPLH A+ GH V L+ GA+
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 91 IFALDNDLQTPLDAAASREQNECVALL 117
+ ++TPL AA E L
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 39.3 bits (90), Expect = 0.007
Identities = 39/146 (26%), Positives = 60/146 (41%), Gaps = 31/146 (21%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGN---------------- 44
T + AA +++LE++K + + N++ EDG TP +A G+
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 45 -LEALEI------------ICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANI 91
L AL I + +PD G TPLH AA + + L+N GA++
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 92 FALDNDLQTPLDAAASREQNECVALL 117
+ TPL A+ R V LL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 38.5 bits (88), Expect = 0.011
Identities = 35/120 (29%), Positives = 47/120 (39%)
Query: 29 DEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFG 88
+ D T L AA GNL+ G D + C+ G LH A+ GH V L++
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 89 ANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNARRQIK 148
+ T L AA Q+E V L N + K T L AQ+N +K
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 62.8 bits (151), Expect = 6e-10
Identities = 38/116 (32%), Positives = 62/116 (53%), Gaps = 4/116 (3%)
Query: 6 HQAASDSYLELLKEATKRDLN--LSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
HQA+ E++K ++ N D+ G+TP +AA +G LE+L I+ S G + + +
Sbjct: 78 HQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQAL 137
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGA--NIFALDNDLQTPLDAAASREQNECVALL 117
TPL AA GH CV L++ GA +++ ++ Q P+ AAA + + LL
Sbjct: 138 DKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 193
Score = 41.6 bits (96), Expect = 0.001
Identities = 39/140 (27%), Positives = 64/140 (45%), Gaps = 5/140 (3%)
Query: 6 HQAASDSY---LELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRC- 61
H AAS + +++L EA D N + + TP LA +G ++ L ++ G + +
Sbjct: 11 HLAASQGHWKIVQILLEAGA-DPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
Query: 62 DIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAA 121
+ G LH A+ +A + L+ GAN D+ TPL AA + E +++L +
Sbjct: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 129
Query: 122 TAQNIMNPKKVTRLKEQAQK 141
N K T L AQ+
Sbjct: 130 ANVNCQALDKATPLFIAAQE 149
Score = 39.7 bits (91), Expect = 0.005
Identities = 29/111 (26%), Positives = 48/111 (43%), Gaps = 1/111 (0%)
Query: 31 DGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGAN 90
+G LAA G+ + ++I+ G DP+ + TPL A NG + L+ GAN
Sbjct: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
Query: 91 IFALDNDL-QTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQ 140
+ + L A+ +E E + LL + + + +T L AQ
Sbjct: 65 VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQ 115
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 62.8 bits (151), Expect = 6e-10
Identities = 38/116 (32%), Positives = 62/116 (53%), Gaps = 4/116 (3%)
Query: 6 HQAASDSYLELLKEATKRDLN--LSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
HQA+ E++K ++ N D+ G+TP +AA +G LE+L I+ S G + + +
Sbjct: 151 HQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQAL 210
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGA--NIFALDNDLQTPLDAAASREQNECVALL 117
TPL AA GH CV L++ GA +++ ++ Q P+ AAA + + LL
Sbjct: 211 DKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 266
Score = 43.5 bits (101), Expect = 4e-04
Identities = 34/141 (24%), Positives = 63/141 (44%), Gaps = 6/141 (4%)
Query: 6 HQAASDSYLELLK-----EATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
H+AA + +E L+ ++++ + + +G LAA G+ + ++I+ G DP+
Sbjct: 48 HEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNA 107
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDL-QTPLDAAASREQNECVALLDK 119
+ TPL A NG + L+ GAN+ + L A+ +E E + LL +
Sbjct: 108 TTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLR 167
Query: 120 AATAQNIMNPKKVTRLKEQAQ 140
+ + +T L AQ
Sbjct: 168 KGANKECQDDFGITPLFVAAQ 188
Score = 41.6 bits (96), Expect = 0.001
Identities = 39/140 (27%), Positives = 64/140 (45%), Gaps = 5/140 (3%)
Query: 6 HQAASDSY---LELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRC- 61
H AAS + +++L EA D N + + TP LA +G ++ L ++ G + +
Sbjct: 84 HLAASQGHWKIVQILLEAGA-DPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 142
Query: 62 DIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAA 121
+ G LH A+ +A + L+ GAN D+ TPL AA + E +++L +
Sbjct: 143 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 202
Query: 122 TAQNIMNPKKVTRLKEQAQK 141
N K T L AQ+
Sbjct: 203 ANVNCQALDKATPLFIAAQE 222
Score = 34.3 bits (77), Expect = 0.22
Identities = 17/49 (34%), Positives = 25/49 (51%)
Query: 38 LAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVN 86
LAA GN++ L + +G D D G P+H AA + C+ L+N
Sbjct: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLIN 64
>gi|54792780 DDHD domain containing 2 [Homo sapiens]
Length = 711
Score = 62.4 bits (150), Expect = 7e-10
Identities = 31/60 (51%), Positives = 39/60 (65%)
Query: 344 DATPLEVFLLSQHLEEFLPIFKREQIDLEALLLCSDEDLQSIQMQLGPRKKVLNAINRRK 403
D LE L L EF IF++E++D EAL LC+D DLQ I + LGPRKK+LN + RK
Sbjct: 386 DTPTLEEDLKKLQLSEFFDIFEKEKVDKEALALCTDRDLQEIGIPLGPRKKILNYFSTRK 445
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 62.4 bits (150), Expect = 7e-10
Identities = 40/118 (33%), Positives = 58/118 (49%), Gaps = 3/118 (2%)
Query: 2 STRYHQAASDSYLE---LLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDP 58
ST H AA LE LL + D+N D G TP + AA H ++E + ++ +RG D
Sbjct: 718 STCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADV 777
Query: 59 DRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVAL 116
D N LH+A+ G A L+N ++ A++ TPL AA ++CV L
Sbjct: 778 TLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 835
Score = 43.5 bits (101), Expect = 4e-04
Identities = 34/118 (28%), Positives = 56/118 (47%), Gaps = 3/118 (2%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA +E+ + N++ D+ TP + A + +LE + RGG
Sbjct: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFG-ANIFALDNDLQTPLDAAASREQNECVALL 117
+ G+T LH AA G+ VS L++ G ++ A D+ TP+ AA + E + +L
Sbjct: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 770
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 62.4 bits (150), Expect = 7e-10
Identities = 40/118 (33%), Positives = 58/118 (49%), Gaps = 3/118 (2%)
Query: 2 STRYHQAASDSYLE---LLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDP 58
ST H AA LE LL + D+N D G TP + AA H ++E + ++ +RG D
Sbjct: 752 STCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADV 811
Query: 59 DRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVAL 116
D N LH+A+ G A L+N ++ A++ TPL AA ++CV L
Sbjct: 812 TLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 869
Score = 43.5 bits (101), Expect = 4e-04
Identities = 34/118 (28%), Positives = 56/118 (47%), Gaps = 3/118 (2%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA +E+ + N++ D+ TP + A + +LE + RGG
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFG-ANIFALDNDLQTPLDAAASREQNECVALL 117
+ G+T LH AA G+ VS L++ G ++ A D+ TP+ AA + E + +L
Sbjct: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 804
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 61.2 bits (147), Expect = 2e-09
Identities = 37/124 (29%), Positives = 61/124 (49%), Gaps = 9/124 (7%)
Query: 7 QAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGN 66
Q ++ +++L E D+NL E+G T ++A N EAL+I+ +G P + + WG
Sbjct: 140 QGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGC 199
Query: 67 TPLHFAASNGHAHCVSFLVNFG--------ANIFALDNDLQTPLDAAASREQNECVAL-L 117
P+H AA +G C+ ++ FG +I ++N TPL A E + + L
Sbjct: 200 FPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCL 259
Query: 118 DKAA 121
D A
Sbjct: 260 DNGA 263
Score = 47.0 bits (110), Expect = 3e-05
Identities = 37/114 (32%), Positives = 58/114 (50%), Gaps = 3/114 (2%)
Query: 3 TRYHQAASDSYLELLKEATKRD-LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGD-PDR 60
T H AA + + ++++ K+ L LSD +G T A+ G + +++I DR
Sbjct: 484 TPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDR 543
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECV 114
D GNT LHFAA GHA V+ L++ A+I L+ + L A ++ E V
Sbjct: 544 LDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVV 596
Score = 38.9 bits (89), Expect = 0.009
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 39 AAYHGNLEALEIICSRGGDPD---RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALD 95
AA G +E +E I +R + D +GNTPLH A V FL++ GAN +
Sbjct: 70 AAAEGQIELMEKI-TRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRN 128
Query: 96 NDLQTPLDAAASREQNECVALL 117
++ PL A NE + +L
Sbjct: 129 FNMMAPLHIAVQGMNNEVMKVL 150
Score = 38.1 bits (87), Expect = 0.015
Identities = 37/156 (23%), Positives = 59/156 (37%), Gaps = 41/156 (26%)
Query: 3 TRYHQAASDSYLELLKE--ATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H+A+ + EL + D+N D +G +P +LA + + ++ S+G D
Sbjct: 311 TMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDI 370
Query: 61 CDIWGN--------------------------------------TPLHFAASNGHAHCVS 82
D +G TPLH+A G V+
Sbjct: 371 KDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVN 430
Query: 83 FLVNFGANIFALDNDLQTPLDAAASREQ-NECVALL 117
L+ F +I + D ++PL AAS + N C LL
Sbjct: 431 NLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLL 466
Score = 37.7 bits (86), Expect = 0.019
Identities = 26/85 (30%), Positives = 41/85 (48%), Gaps = 4/85 (4%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDP---DRCDIWGNTPLHFAASNGHAHCV 81
++ +D +P AA +G + + + D + D+ G TPLH AA NGH V
Sbjct: 439 IHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVV 498
Query: 82 SFLVNFGANIFALDNDLQTPLDAAA 106
L+ GA +F D++ T L A+
Sbjct: 499 QLLLKKGA-LFLSDHNGWTALHHAS 522
Score = 37.0 bits (84), Expect = 0.033
Identities = 21/71 (29%), Positives = 38/71 (53%), Gaps = 4/71 (5%)
Query: 6 HQAASDSYLELLKEATKRD----LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRC 61
H AA++ +EL+++ T+ L+ D+ G TP A +E+++ + SRG +P+
Sbjct: 68 HYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLR 127
Query: 62 DIWGNTPLHFA 72
+ PLH A
Sbjct: 128 NFNMMAPLHIA 138
Score = 35.4 bits (80), Expect = 0.097
Identities = 43/165 (26%), Positives = 71/165 (43%), Gaps = 11/165 (6%)
Query: 2 STRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEI-ICSRGGDP 58
+T H A + LE++K + ++ T AA G E +++ I S G
Sbjct: 240 ATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSV 299
Query: 59 D---RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLD-AAASREQNECV 114
D D T LH A+ H +L++ GA+I +D++ ++PL A AS N
Sbjct: 300 DIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVN 359
Query: 115 ALLDKAATA---QNI-MNPKKVTRLKEQAQKNARRQIKECERLQE 155
LL K A N N +T + KN R + + ++++E
Sbjct: 360 LLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKE 404
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 60.5 bits (145), Expect = 3e-09
Identities = 35/86 (40%), Positives = 46/86 (53%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
D+N D G T AA GN+E L ++ S G D R D +G TPLH+AA+NG C
Sbjct: 415 DINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVT 474
Query: 84 LVNFGANIFALDNDLQTPLDAAASRE 109
LV GA + D +PL AA+ +
Sbjct: 475 LVTAGAGVNEADCKGCSPLHYAAASD 500
Score = 55.8 bits (133), Expect = 7e-08
Identities = 31/105 (29%), Positives = 55/105 (52%)
Query: 22 KRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCV 81
K ++N+ D++ TP AAY G++ L+++ G + + D TPLH AA++ + +
Sbjct: 31 KENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVL 90
Query: 82 SFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNI 126
L+ A++ A D QTPL AA+ +C L ++ N+
Sbjct: 91 GLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNV 135
Score = 54.3 bits (129), Expect = 2e-07
Identities = 26/67 (38%), Positives = 38/67 (56%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
D+N ++G +P +AA HG +I+ G + D D +GNTPLH AA GH +S
Sbjct: 298 DVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIST 357
Query: 84 LVNFGAN 90
L+ GA+
Sbjct: 358 LMTNGAD 364
Score = 51.2 bits (121), Expect = 2e-06
Identities = 32/124 (25%), Positives = 61/124 (49%), Gaps = 5/124 (4%)
Query: 3 TRYHQAASDSYLE----LLKEATKRDL-NLSDEDGMTPTLLAAYHGNLEALEIICSRGGD 57
T H AA+ + + L+ + D+ ++ D G TP +LA +G+++ + ++ +G
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713
Query: 58 PDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
D D+ G T LH A G C++ L++ A + D +TP+ A++ + L
Sbjct: 714 ADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTL 773
Query: 118 DKAA 121
+AA
Sbjct: 774 LQAA 777
Score = 49.7 bits (117), Expect = 5e-06
Identities = 40/115 (34%), Positives = 53/115 (46%), Gaps = 3/115 (2%)
Query: 6 HQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H AA +LE+LK R DL D G AA G +E ++ + G + D +
Sbjct: 178 HWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNA 237
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLD-AAASREQNECVALL 117
+GNT LH A G LVN GAN+ ++ TPL AA S C+ LL
Sbjct: 238 FGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELL 292
Score = 48.9 bits (115), Expect = 8e-06
Identities = 34/109 (31%), Positives = 51/109 (46%), Gaps = 2/109 (1%)
Query: 11 DSYLELLKEAT-KRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPL 69
DS E+L A + +N D G TP AA+ N+ L ++ + + D G T L
Sbjct: 836 DSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 895
Query: 70 HFAASNGHAHCVSFLVNFG-ANIFALDNDLQTPLDAAASREQNECVALL 117
AA NG V FL+ G A++ LD + T L A S+ +C ++
Sbjct: 896 MTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMI 944
Score = 48.5 bits (114), Expect = 1e-05
Identities = 30/93 (32%), Positives = 46/93 (49%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFL 84
LN++D G + A + G+LE + ++ ++G + CD PLH+AA GH + L
Sbjct: 133 LNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLL 192
Query: 85 VNFGANIFALDNDLQTPLDAAASREQNECVALL 117
V GA++ D L AA+ Q E V L
Sbjct: 193 VARGADLGCKDRKGYGLLHTAAASGQIEVVKYL 225
Score = 48.1 bits (113), Expect = 1e-05
Identities = 40/132 (30%), Positives = 57/132 (43%), Gaps = 2/132 (1%)
Query: 6 HQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H A +LE + + LN+ D+ P AA+ G+LE L+++ +RG D D
Sbjct: 145 HHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDR 204
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G LH AA++G V +L+ GA I + T L A Q+ L A
Sbjct: 205 KGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGAN 264
Query: 124 QNIMNPKKVTRL 135
N N K T L
Sbjct: 265 VNQPNDKGFTPL 276
Score = 46.6 bits (109), Expect = 4e-05
Identities = 31/98 (31%), Positives = 47/98 (47%)
Query: 49 EIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASR 108
E + S G D + D G T LH AAS G+ C++ L++ GA++ D +TPL AA+
Sbjct: 407 EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466
Query: 109 EQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNARRQ 146
+C L A N + K + L A + R+
Sbjct: 467 GSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRR 504
Score = 46.6 bits (109), Expect = 4e-05
Identities = 34/108 (31%), Positives = 54/108 (50%), Gaps = 4/108 (3%)
Query: 14 LELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNT---PLH 70
+E L K DL + DE+ T LA G+ + +I + D + + PLH
Sbjct: 907 VEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLH 966
Query: 71 FAASNGHAHCVSFLVNFGANIFALDNDLQTP-LDAAASREQNECVALL 117
AA NG A V L++ GA + A+D + TP L A +++ +C+AL+
Sbjct: 967 IAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALI 1014
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/110 (30%), Positives = 47/110 (42%), Gaps = 2/110 (1%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGD--PDRCDIWGNTPLHFAASNGHAHCV 81
D +L D G T AA +GN + LE++ + D +PLH AA NGH +
Sbjct: 542 DPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEAL 601
Query: 82 SFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKK 131
L N+ D+ +T L A R ECV +L + I K+
Sbjct: 602 KTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651
Score = 41.6 bits (96), Expect = 0.001
Identities = 36/118 (30%), Positives = 54/118 (45%), Gaps = 4/118 (3%)
Query: 3 TRYHQAAS---DSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
T H+AA+ + L LL A D+N D+ TP +AA + + E + +
Sbjct: 76 TPLHRAAASRNEKVLGLLL-AHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN 134
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
D G + LH A +GH V+ L+N GA++ D + PL AA E + LL
Sbjct: 135 VADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLL 192
Score = 40.0 bits (92), Expect = 0.004
Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 1/84 (1%)
Query: 24 DLNLSDEDGMTPTLLAAYHGN-LEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVS 82
++N ++ G TP +AA N LE++ + G D + G +PLH AA +G
Sbjct: 264 NVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQ 323
Query: 83 FLVNFGANIFALDNDLQTPLDAAA 106
L+ G+ I D TPL AA
Sbjct: 324 ILIQNGSEIDCADKFGNTPLHVAA 347
Score = 38.9 bits (89), Expect = 0.009
Identities = 31/112 (27%), Positives = 50/112 (44%), Gaps = 18/112 (16%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
+++ +D+ G TP +AA +G+ + + + G D R I PLH A G + C
Sbjct: 331 EIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRK 390
Query: 84 LVNFG-----------ANIFALDNDLQTP-------LDAAASREQNECVALL 117
L++ G ++ + D+ TP L AAAS EC+ LL
Sbjct: 391 LLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLL 442
Score = 38.5 bits (88), Expect = 0.011
Identities = 28/108 (25%), Positives = 46/108 (42%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
++N D +TP AA N + L ++ + D + D TPLH AA+N C
Sbjct: 66 NVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEA 125
Query: 84 LVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKK 131
L +++ D ++ L A E V LL + N+ + K+
Sbjct: 126 LAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKE 173
Score = 37.4 bits (85), Expect = 0.025
Identities = 27/93 (29%), Positives = 46/93 (49%), Gaps = 3/93 (3%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFL 84
L+++D+ P + A + ++E + + S+ + + D TPLH AA G + L
Sbjct: 4 LSITDQP---PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL 60
Query: 85 VNFGANIFALDNDLQTPLDAAASREQNECVALL 117
+ GAN+ A D TPL AA+ + + LL
Sbjct: 61 LMSGANVNAKDTLWLTPLHRAAASRNEKVLGLL 93
Score = 34.7 bits (78), Expect = 0.16
Identities = 25/93 (26%), Positives = 39/93 (41%), Gaps = 5/93 (5%)
Query: 29 DEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIW----GNTPLHFAASNGHAHCVSFL 84
D G TP LA+ G+ L + D D G +P+H+A+ GH C+ L
Sbjct: 751 DFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810
Query: 85 VNFGANIFALDNDLQTPLDAAASREQNECVALL 117
+ + L+ + TPL A Q+ +L
Sbjct: 811 LEHSPFSY-LEGNPFTPLHCAVINNQDSTTEML 842
Score = 33.1 bits (74), Expect = 0.48
Identities = 34/130 (26%), Positives = 52/130 (40%), Gaps = 14/130 (10%)
Query: 2 STRYHQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRC 61
S ++ AASD+Y + A + D + P + LE + G DP
Sbjct: 491 SPLHYAAASDTY----RRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLR 546
Query: 62 DIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQ-----TPLDAAASREQNECVAL 116
D G T +H+AA+ G+ + L+ N D++ +PL AA C AL
Sbjct: 547 DRQGYTAVHYAAAYGNRQNLELLLEMSFNCL---EDVESTIPVSPLHLAA--YNGHCEAL 601
Query: 117 LDKAATAQNI 126
A T N+
Sbjct: 602 KTLAETLVNL 611
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 60.1 bits (144), Expect = 4e-09
Identities = 40/129 (31%), Positives = 56/129 (43%), Gaps = 4/129 (3%)
Query: 17 LKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNG 76
L T L+ D+DG T AA G+ + L + GG+ D+WG TPLH AA NG
Sbjct: 225 LVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEIS-ADLWGGTPLHDAAENG 283
Query: 77 HAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLK 136
C LV GA + D D T D + + C L T +N+ +V
Sbjct: 284 ELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL---RTVENLSVEHRVLSRD 340
Query: 137 EQAQKNARR 145
A+ A++
Sbjct: 341 PSAELEAKQ 349
Score = 48.9 bits (115), Expect = 8e-06
Identities = 35/106 (33%), Positives = 51/106 (48%), Gaps = 2/106 (1%)
Query: 14 LELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSR-GGDPDRCDIWGNTPLHFA 72
L LL E +N ++G TP LA G+LE + + G DP G TPLH A
Sbjct: 154 LRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAA 213
Query: 73 ASNGHAHCVSFLVN-FGANIFALDNDLQTPLDAAASREQNECVALL 117
A GH+ + +LV+ ++ D D T + AASR + ++ L
Sbjct: 214 AQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWL 259
Score = 35.4 bits (80), Expect = 0.097
Identities = 37/139 (26%), Positives = 57/139 (41%), Gaps = 11/139 (7%)
Query: 2 STRYHQAASDSYLELLKEATKRD---LNLSDEDGMTPTLLAAYHGNLEALE-IICSRGGD 57
+T H A++ +L L+ + + D G T LAA G+ E + ++ GGD
Sbjct: 71 ATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGD 130
Query: 58 PDRCDIWGNTPLHFAASNGHAHCVSFLV-NFGANIFALDNDLQTPLDAAASREQNECVAL 116
P G P+H+AA+ G + LV ++ + A + TPL A E
Sbjct: 131 PTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQY 190
Query: 117 L------DKAATAQNIMNP 129
L D A A + M P
Sbjct: 191 LVQECGADPHARAHDGMTP 209
Score = 32.3 bits (72), Expect = 0.82
Identities = 31/105 (29%), Positives = 43/105 (40%), Gaps = 5/105 (4%)
Query: 7 QAASDSYLELLKEATKRDL---NLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
QAA L++L+ L +L D P AA G L L + P
Sbjct: 8 QAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
Query: 64 W-GNTPLHFAASNGHAHCVSFLVN-FGANIFALDNDLQTPLDAAA 106
G TP H A++ GH C+ +L++ G + DN T L AA
Sbjct: 68 RNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAA 112
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 60.1 bits (144), Expect = 4e-09
Identities = 30/81 (37%), Positives = 47/81 (58%)
Query: 28 SDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNF 87
+D+ G T A+ +GN + ++++ G DP++ D GNTPLH AA H ++ L+
Sbjct: 139 ADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRG 198
Query: 88 GANIFALDNDLQTPLDAAASR 108
GA + ALD +TPL A S+
Sbjct: 199 GARVDALDRAGRTPLHLAKSK 219
Score = 43.9 bits (102), Expect = 3e-04
Identities = 34/132 (25%), Positives = 54/132 (40%), Gaps = 5/132 (3%)
Query: 39 AAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDL 98
+A ++E ++ + G DP D G T LHFA+ NG+ V L++ GA+ D
Sbjct: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
Query: 99 QTPLDAAASREQNECVALLDKAATAQNIMN-----PKKVTRLKEQAQKNARRQIKECERL 153
TPL AA + L + + ++ P + + K + Q E RL
Sbjct: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAVRL 236
Query: 154 QEKHQNKMAHTY 165
+ K M Y
Sbjct: 237 EVKQIIHMLREY 248
Score = 35.0 bits (79), Expect = 0.13
Identities = 23/64 (35%), Positives = 28/64 (43%), Gaps = 6/64 (9%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAAS------NGH 77
D N D G TP LAA ++ + + G D D G TPLH A S GH
Sbjct: 168 DPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGH 227
Query: 78 AHCV 81
A C+
Sbjct: 228 AQCL 231
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 59.7 bits (143), Expect = 5e-09
Identities = 39/141 (27%), Positives = 67/141 (47%), Gaps = 2/141 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H A + +++++ K ++ E G+TP +AA+ G++ + + G P+
Sbjct: 402 TPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
++ G T LH AA +G A V +LV GA + A D QTPL +A + + V L +
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521
Query: 121 ATAQNIMNPKKVTRLKEQAQK 141
+ N T L A++
Sbjct: 522 GASPNAATTSGYTPLHLSARE 542
Score = 58.9 bits (141), Expect = 8e-09
Identities = 41/142 (28%), Positives = 68/142 (47%), Gaps = 7/142 (4%)
Query: 6 HQAASDSYLELLKEATKRD--LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H AA + +++++ R+ +NLS++ G+TP LAA + E++ ++G D
Sbjct: 669 HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 728
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G TPLH G+ V+FL+ A + A + TPL AA + + +L
Sbjct: 729 MGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVL-----L 783
Query: 124 QNIMNPKKVTRLKEQAQKNARR 145
QN +P ++T A ARR
Sbjct: 784 QNNASPNELTVNGNTALGIARR 805
Score = 57.8 bits (138), Expect = 2e-08
Identities = 42/139 (30%), Positives = 64/139 (46%), Gaps = 2/139 (1%)
Query: 5 YHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCD 62
Y +AA +LE + K D+N+ +++G+ LA+ G++E + + R + D
Sbjct: 45 YLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAAT 104
Query: 63 IWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAAT 122
GNT LH A+ G A V LV GAN+ A + TPL AA E V L
Sbjct: 105 KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
Query: 123 AQNIMNPKKVTRLKEQAQK 141
+Q++ T L Q+
Sbjct: 165 SQSLATEDGFTPLAVALQQ 183
Score = 54.3 bits (129), Expect = 2e-07
Identities = 34/126 (26%), Positives = 64/126 (50%), Gaps = 2/126 (1%)
Query: 6 HQAASDSYLELLKEATKRDLNL--SDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H A+ + ++E++ E +R+ N+ + + G T +A+ G E ++++ + G + +
Sbjct: 79 HLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQ 138
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G TPL+ AA H V FL++ GA+ D TPL A + ++ V+LL + T
Sbjct: 139 NGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTK 198
Query: 124 QNIMNP 129
+ P
Sbjct: 199 GKVRLP 204
Score = 53.5 bits (127), Expect = 3e-07
Identities = 36/100 (36%), Positives = 53/100 (53%), Gaps = 7/100 (7%)
Query: 26 NLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD---RCDIWGNTPLHFAASNGHAHCVS 82
++ + G TP +AA++GN+ ++ +R D R DI TPLH A+ G+A+ V
Sbjct: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDI---TPLHVASKRGNANMVK 285
Query: 83 FLVNFGANIFALDNDLQTPLDAAASREQNECV-ALLDKAA 121
L++ GA I A D TPL A + V LLD+AA
Sbjct: 286 LLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA 325
Score = 51.6 bits (122), Expect = 1e-06
Identities = 34/135 (25%), Positives = 60/135 (44%), Gaps = 2/135 (1%)
Query: 3 TRYHQAASDSYLELLKEATK--RDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA E+++ + + +D TP ++A G + ++ + +G P+
Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G TPLH +A GH +FL++ GA++ TPL AA + E LL +
Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587
Query: 121 ATAQNIMNPKKVTRL 135
+ + + +T L
Sbjct: 588 SASPDAAGKSGLTPL 602
Score = 51.2 bits (121), Expect = 2e-06
Identities = 32/117 (27%), Positives = 54/117 (46%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFL 84
L+++ + G TP +AA +G LE ++ + PD G TPLH AA + L
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Query: 85 VNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQK 141
++ GA+ A + TPL AA + Q + L + N + + + + AQ+
Sbjct: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQE 674
Score = 49.7 bits (117), Expect = 5e-06
Identities = 47/169 (27%), Positives = 74/169 (43%), Gaps = 10/169 (5%)
Query: 3 TRYHQAASDSYLE----LLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDP 58
T H AA LE LL+++ D + + G+TP +AA++ N + ++ +G P
Sbjct: 567 TPLHVAAKYGKLEVANLLLQKSASPDA--AGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624
Query: 59 DRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLD 118
G TPLH AA + L+ +GA+ A+ + AA + V+LL
Sbjct: 625 HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684
Query: 119 KAATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKH---QNKMAHT 164
N+ N +T L AQ++ R + E Q H Q KM +T
Sbjct: 685 GRNANVNLSNKSGLTPLHLAAQED-RVNVAEVLVNQGAHVDAQTKMGYT 732
Score = 46.6 bits (109), Expect = 4e-05
Identities = 31/102 (30%), Positives = 47/102 (46%), Gaps = 2/102 (1%)
Query: 16 LLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASN 75
LL A D ++ +TP +A+ GN ++++ RG D G TPLH A +
Sbjct: 254 LLNRAAAVDFTARND--ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARS 311
Query: 76 GHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
GH V L++ A I + + +PL A + CV LL
Sbjct: 312 GHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLL 353
Score = 45.1 bits (105), Expect = 1e-04
Identities = 32/145 (22%), Positives = 62/145 (42%), Gaps = 2/145 (1%)
Query: 6 HQAASDSYLELLKEATKRDLNLSD--EDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H A +L ++ + ++ + D D +T +AA+ G+ + +++ + +P+ +
Sbjct: 339 HMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKAL 398
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATA 123
G TPLH A + L+ GA+I A+ TP+ AA V+ L +
Sbjct: 399 NGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 458
Query: 124 QNIMNPKKVTRLKEQAQKNARRQIK 148
N N + T L A+ ++
Sbjct: 459 PNTTNVRGETALHMAARSGQAEVVR 483
Score = 44.7 bits (104), Expect = 2e-04
Identities = 38/149 (25%), Positives = 57/149 (38%), Gaps = 13/149 (8%)
Query: 6 HQAASDSYLELLKEATKR-------------DLNLSDEDGMTPTLLAAYHGNLEALEIIC 52
H AA + Y L A K D N G+ LAA G+++ + ++
Sbjct: 625 HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684
Query: 53 SRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNE 112
R + + + G TPLH AA + LVN GA++ A TPL +
Sbjct: 685 GRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIK 744
Query: 113 CVALLDKAATAQNIMNPKKVTRLKEQAQK 141
V L + + N T L + AQ+
Sbjct: 745 IVNFLLQHSAKVNAKTKNGYTPLHQAAQQ 773
Score = 44.3 bits (103), Expect = 2e-04
Identities = 33/117 (28%), Positives = 53/117 (45%), Gaps = 2/117 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLSDE--DGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA + ++ K + N + + +G TP +A ++ +E++ G
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
G TP+H AA GH + VS L++ GA+ + +T L AA Q E V L
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Score = 42.0 bits (97), Expect = 0.001
Identities = 36/118 (30%), Positives = 47/118 (39%)
Query: 31 DGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGAN 90
D L AA G+LE G D + C+ G LH A+ GH VS L+ AN
Sbjct: 40 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 99
Query: 91 IFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNARRQIK 148
+ A T L A+ Q E V +L N + T L AQ+N +K
Sbjct: 100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVK 157
Score = 41.6 bits (96), Expect = 0.001
Identities = 33/122 (27%), Positives = 49/122 (40%), Gaps = 3/122 (2%)
Query: 3 TRYHQAASDSYLELLKEATKRD--LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H A+ ++K R ++ DG+TP A G+ + +E++ R
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAA-SREQNECVALLDK 119
G +PLH A H +CV L+ + + ND T L AA LLDK
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Query: 120 AA 121
A
Sbjct: 390 KA 391
Score = 40.0 bits (92), Expect = 0.004
Identities = 34/118 (28%), Positives = 48/118 (40%), Gaps = 5/118 (4%)
Query: 26 NLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLV 85
N + G TP L+A G+ + + G G TPLH AA G + L+
Sbjct: 526 NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585
Query: 86 NFGANIFALDNDLQTPLDAAASRE-QNECVALLDKAAT----AQNIMNPKKVTRLKEQ 138
A+ A TPL AA + Q + LLD+ A+ A+N P + K Q
Sbjct: 586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQ 643
Score = 38.9 bits (89), Expect = 0.009
Identities = 41/152 (26%), Positives = 64/152 (42%), Gaps = 34/152 (22%)
Query: 3 TRYHQAASDSYLELLKEATKRDLN--LSDEDGMTPTLLAAYHGNLEALEI---------- 50
T + AA +++LE++K + L+ EDG TP +A G+ + + +
Sbjct: 142 TPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKV 201
Query: 51 ------ICSRGGDPDRCDIW-------------GNTPLHFAASNGHAHCVSFLVNFGANI 91
I +R D + G TPLH AA G+ + + L+N A +
Sbjct: 202 RLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAV 261
Query: 92 -FALDNDLQTPLDAAASR-EQNECVALLDKAA 121
F ND+ TPL A+ R N LLD+ A
Sbjct: 262 DFTARNDI-TPLHVASKRGNANMVKLLLDRGA 292
Score = 37.0 bits (84), Expect = 0.033
Identities = 37/124 (29%), Positives = 54/124 (43%), Gaps = 5/124 (4%)
Query: 3 TRYHQAASDSYLELLKEATKRDL--NLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA ++ ++ + N ++ G T +AA G E + + G +
Sbjct: 435 TPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEA 494
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVA--LLD 118
TPLH +A G A V L+ GA+ A TPL +A RE +E VA LLD
Sbjct: 495 KAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSA-REGHEDVAAFLLD 553
Query: 119 KAAT 122
A+
Sbjct: 554 HGAS 557
Score = 32.0 bits (71), Expect = 1.1
Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 2/69 (2%)
Query: 16 LLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASN 75
LL+ + K +N ++G TP AA G+ + ++ P+ + GNT L A
Sbjct: 749 LLQHSAK--VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRL 806
Query: 76 GHAHCVSFL 84
G+ V L
Sbjct: 807 GYISVVDTL 815
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 59.7 bits (143), Expect = 5e-09
Identities = 45/169 (26%), Positives = 79/169 (46%), Gaps = 8/169 (4%)
Query: 26 NLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLV 85
N+ D G TP AAY G + + ++ DP+ D G T LH++ +NG+ + L+
Sbjct: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Query: 86 NFGANIFALDNDLQ--TPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQA---Q 140
+F A ++N+ + TPLD A E++E + + + A +I + + K QA
Sbjct: 510 DFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHG-ALSIAAIQDIAAFKIQAVYKG 568
Query: 141 KNARRQIKECERLQEKHQ--NKMAHTYSKEESGTLSSSKGTFSRSSPSN 187
R+ ++ + L KH+ K A +EE ++ R SP +
Sbjct: 569 YKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQQKGRRSPDS 617
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/131 (29%), Positives = 56/131 (42%), Gaps = 4/131 (3%)
Query: 2 STRYHQAASDSYLELLKEATKRDLNLSDED--GMTPTLLAAYHGNLEALEIICSRGGDPD 59
+T H AA ++ E +K K D D G T + AA G+ + L + S D D
Sbjct: 290 ATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID 349
Query: 60 --RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
D +G T LH AA +GH V L+ A + A D TPL A + + L
Sbjct: 350 INMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTL 409
Query: 118 DKAATAQNIMN 128
K ++++
Sbjct: 410 IKGGARVDLVD 420
Score = 47.4 bits (111), Expect = 2e-05
Identities = 48/158 (30%), Positives = 70/158 (44%), Gaps = 14/158 (8%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEII-CSRGGDPD 59
T H +A + E +K K D N+ D +G P AA H + A+ + C P
Sbjct: 151 TALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPT 210
Query: 60 RC-----DIWGNTPLHFAASNGHAHCVSFLVNF-GANIFALDNDLQTPLDAAASREQNEC 113
D G TPLHFA ++G+ V L ++ NI + DN +TPL AA +
Sbjct: 211 ESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQI 270
Query: 114 VALL---DKAATAQNIMNPKKVTRLKEQAQKNARRQIK 148
V LL +K+ T + + + T L AQ N +K
Sbjct: 271 VHLLLERNKSGTIPS--DSQGATPLHYAAQSNFAETVK 306
Score = 45.4 bits (106), Expect = 9e-05
Identities = 33/122 (27%), Positives = 49/122 (40%), Gaps = 2/122 (1%)
Query: 29 DEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFG 88
D+ G TP + L+ + + G D ++ D T LH AA G+ + L+
Sbjct: 45 DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104
Query: 89 ANIFALDNDLQTPLDAAASREQNECVALLDK--AATAQNIMNPKKVTRLKEQAQKNARRQ 146
AN D + TPL +C+ALL K A + + K T L A N
Sbjct: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEH 164
Query: 147 IK 148
+K
Sbjct: 165 VK 166
Score = 45.4 bits (106), Expect = 9e-05
Identities = 26/100 (26%), Positives = 47/100 (47%)
Query: 7 QAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGN 66
+ + D +L + D+N++D+ G T AA G++ ++++ D D+ +
Sbjct: 332 KGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKH 391
Query: 67 TPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAA 106
TPL A GH + L+ GA + +D D + L AA
Sbjct: 392 TPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Score = 44.3 bits (103), Expect = 2e-04
Identities = 36/135 (26%), Positives = 58/135 (42%), Gaps = 2/135 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLSDEDGM--TPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA ++ +K + + + D M TP A G+ + ++ + G D
Sbjct: 359 TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDL 418
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
D G++ LH+AA G+A L+ N D +TPL AA C+A+L +
Sbjct: 419 VDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEN 478
Query: 121 ATAQNIMNPKKVTRL 135
NI + + T L
Sbjct: 479 NADPNIQDKEGRTAL 493
Score = 42.7 bits (99), Expect = 6e-04
Identities = 32/113 (28%), Positives = 55/113 (48%), Gaps = 2/113 (1%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFL 84
++L D+DG + AA GN + +I+ +P+ D G TPL AA G+ +C++ L
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475
Query: 85 VNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIM--NPKKVTRL 135
+ A+ D + +T L + + + + LL A N M N ++ T L
Sbjct: 476 MENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPL 528
Score = 40.0 bits (92), Expect = 0.004
Identities = 29/98 (29%), Positives = 46/98 (46%), Gaps = 2/98 (2%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
D+N +D T LAA GN ++++ +R + + D+ TPLH + C++
Sbjct: 73 DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132
Query: 84 LVNFGA--NIFALDNDLQTPLDAAASREQNECVALLDK 119
L+ F A + D + QT L +A E V LL K
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK 170
Score = 35.0 bits (79), Expect = 0.13
Identities = 36/134 (26%), Positives = 57/134 (42%), Gaps = 9/134 (6%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLSDED--GMTPTLLAAYHGNLEALEIICS--RGGDP 58
T H AA +K R N +D MTP L H + + L ++ G+
Sbjct: 83 TALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEV 142
Query: 59 DRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECV---- 114
D D T LH++A + V L+ +NI D + + PL AA+ + V
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVR 202
Query: 115 ALLDKAATAQNIMN 128
+LD AA ++++N
Sbjct: 203 CILD-AAPTESLLN 215
Score = 33.9 bits (76), Expect = 0.28
Identities = 23/80 (28%), Positives = 37/80 (46%), Gaps = 1/80 (1%)
Query: 39 AAYHGNLEALE-IICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDND 97
AA +G+ AL+ +I D+ D +G TPL + C L+ GA++ D+
Sbjct: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
Query: 98 LQTPLDAAASREQNECVALL 117
+T L AA + + LL
Sbjct: 81 QRTALHLAAQKGNYRFMKLL 100
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 59.7 bits (143), Expect = 5e-09
Identities = 45/169 (26%), Positives = 79/169 (46%), Gaps = 8/169 (4%)
Query: 26 NLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLV 85
N+ D G TP AAY G + + ++ DP+ D G T LH++ +NG+ + L+
Sbjct: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Query: 86 NFGANIFALDNDLQ--TPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQA---Q 140
+F A ++N+ + TPLD A E++E + + + A +I + + K QA
Sbjct: 510 DFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHG-ALSIAAIQDIAAFKIQAVYKG 568
Query: 141 KNARRQIKECERLQEKHQ--NKMAHTYSKEESGTLSSSKGTFSRSSPSN 187
R+ ++ + L KH+ K A +EE ++ R SP +
Sbjct: 569 YKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQQKGRRSPDS 617
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/131 (29%), Positives = 56/131 (42%), Gaps = 4/131 (3%)
Query: 2 STRYHQAASDSYLELLKEATKRDLNLSDED--GMTPTLLAAYHGNLEALEIICSRGGDPD 59
+T H AA ++ E +K K D D G T + AA G+ + L + S D D
Sbjct: 290 ATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID 349
Query: 60 --RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
D +G T LH AA +GH V L+ A + A D TPL A + + L
Sbjct: 350 INMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTL 409
Query: 118 DKAATAQNIMN 128
K ++++
Sbjct: 410 IKGGARVDLVD 420
Score = 47.4 bits (111), Expect = 2e-05
Identities = 48/158 (30%), Positives = 70/158 (44%), Gaps = 14/158 (8%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEII-CSRGGDPD 59
T H +A + E +K K D N+ D +G P AA H + A+ + C P
Sbjct: 151 TALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPT 210
Query: 60 RC-----DIWGNTPLHFAASNGHAHCVSFLVNF-GANIFALDNDLQTPLDAAASREQNEC 113
D G TPLHFA ++G+ V L ++ NI + DN +TPL AA +
Sbjct: 211 ESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQI 270
Query: 114 VALL---DKAATAQNIMNPKKVTRLKEQAQKNARRQIK 148
V LL +K+ T + + + T L AQ N +K
Sbjct: 271 VHLLLERNKSGTIPS--DSQGATPLHYAAQSNFAETVK 306
Score = 45.4 bits (106), Expect = 9e-05
Identities = 33/122 (27%), Positives = 49/122 (40%), Gaps = 2/122 (1%)
Query: 29 DEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFG 88
D+ G TP + L+ + + G D ++ D T LH AA G+ + L+
Sbjct: 45 DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104
Query: 89 ANIFALDNDLQTPLDAAASREQNECVALLDK--AATAQNIMNPKKVTRLKEQAQKNARRQ 146
AN D + TPL +C+ALL K A + + K T L A N
Sbjct: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEH 164
Query: 147 IK 148
+K
Sbjct: 165 VK 166
Score = 45.4 bits (106), Expect = 9e-05
Identities = 26/100 (26%), Positives = 47/100 (47%)
Query: 7 QAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGN 66
+ + D +L + D+N++D+ G T AA G++ ++++ D D+ +
Sbjct: 332 KGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKH 391
Query: 67 TPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAA 106
TPL A GH + L+ GA + +D D + L AA
Sbjct: 392 TPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Score = 44.3 bits (103), Expect = 2e-04
Identities = 36/135 (26%), Positives = 58/135 (42%), Gaps = 2/135 (1%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLSDEDGM--TPTLLAAYHGNLEALEIICSRGGDPDR 60
T H AA ++ +K + + + D M TP A G+ + ++ + G D
Sbjct: 359 TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDL 418
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
D G++ LH+AA G+A L+ N D +TPL AA C+A+L +
Sbjct: 419 VDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEN 478
Query: 121 ATAQNIMNPKKVTRL 135
NI + + T L
Sbjct: 479 NADPNIQDKEGRTAL 493
Score = 42.7 bits (99), Expect = 6e-04
Identities = 32/113 (28%), Positives = 55/113 (48%), Gaps = 2/113 (1%)
Query: 25 LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFL 84
++L D+DG + AA GN + +I+ +P+ D G TPL AA G+ +C++ L
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475
Query: 85 VNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIM--NPKKVTRL 135
+ A+ D + +T L + + + + LL A N M N ++ T L
Sbjct: 476 MENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPL 528
Score = 40.0 bits (92), Expect = 0.004
Identities = 29/98 (29%), Positives = 46/98 (46%), Gaps = 2/98 (2%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
D+N +D T LAA GN ++++ +R + + D+ TPLH + C++
Sbjct: 73 DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132
Query: 84 LVNFGA--NIFALDNDLQTPLDAAASREQNECVALLDK 119
L+ F A + D + QT L +A E V LL K
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK 170
Score = 35.0 bits (79), Expect = 0.13
Identities = 36/134 (26%), Positives = 57/134 (42%), Gaps = 9/134 (6%)
Query: 3 TRYHQAASDSYLELLKEATKRDLNLSDED--GMTPTLLAAYHGNLEALEIICS--RGGDP 58
T H AA +K R N +D MTP L H + + L ++ G+
Sbjct: 83 TALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEV 142
Query: 59 DRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECV---- 114
D D T LH++A + V L+ +NI D + + PL AA+ + V
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVR 202
Query: 115 ALLDKAATAQNIMN 128
+LD AA ++++N
Sbjct: 203 CILD-AAPTESLLN 215
Score = 33.9 bits (76), Expect = 0.28
Identities = 23/80 (28%), Positives = 37/80 (46%), Gaps = 1/80 (1%)
Query: 39 AAYHGNLEALE-IICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDND 97
AA +G+ AL+ +I D+ D +G TPL + C L+ GA++ D+
Sbjct: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
Query: 98 LQTPLDAAASREQNECVALL 117
+T L AA + + LL
Sbjct: 81 QRTALHLAAQKGNYRFMKLL 100
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 59.7 bits (143), Expect = 5e-09
Identities = 43/137 (31%), Positives = 67/137 (48%), Gaps = 4/137 (2%)
Query: 3 TRYHQAASDSYLELL----KEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDP 58
T H AA ++ +L ++ L+ D+ G T AA HG L+AL+ + G D
Sbjct: 126 TLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDH 185
Query: 59 DRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLD 118
+ D GNT LH AA GH + LV+ G ++ + + T L +AA +CV LL
Sbjct: 186 NVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLL 245
Query: 119 KAATAQNIMNPKKVTRL 135
+A + N + K ++ L
Sbjct: 246 RAGSTVNALTQKNLSCL 262
Score = 51.6 bits (122), Expect = 1e-06
Identities = 39/142 (27%), Positives = 64/142 (45%), Gaps = 2/142 (1%)
Query: 3 TRYHQAASDSYLELLK--EATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T +H+AA L+ L + D N+ D++G T LAA G++ L+ + G D +
Sbjct: 161 TAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEE 220
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
+ G T LH AA H CV L+ G+ + AL + L AA + +L A
Sbjct: 221 QNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHA 280
Query: 121 ATAQNIMNPKKVTRLKEQAQKN 142
N+++ + + L + N
Sbjct: 281 GGCANVVDHQGASPLHLAVRHN 302
Score = 48.1 bits (113), Expect = 1e-05
Identities = 38/143 (26%), Positives = 63/143 (44%), Gaps = 4/143 (2%)
Query: 3 TRYHQAASDSY---LELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
T H AA S+ ++LL A +N + ++ AA G+ + ++ GG +
Sbjct: 227 TALHSAAGGSHPDCVQLLLRAGST-VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCAN 285
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDK 119
D G +PLH A + V L+N +++ A+DN QTPL AA + +L
Sbjct: 286 VVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLI 345
Query: 120 AATAQNIMNPKKVTRLKEQAQKN 142
A N+ + + T L + N
Sbjct: 346 AGVDLNLRDKQGKTALAVAVRSN 368
Score = 35.4 bits (80), Expect = 0.097
Identities = 24/95 (25%), Positives = 38/95 (40%)
Query: 26 NLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLV 85
N+ D G +P LA H + ++ + D + D TPLH AA + L+
Sbjct: 285 NVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLL 344
Query: 86 NFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
G ++ D +T L A V ++ KA
Sbjct: 345 IAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379
Score = 34.3 bits (77), Expect = 0.22
Identities = 24/92 (26%), Positives = 42/92 (45%), Gaps = 12/92 (13%)
Query: 6 HQAASDSYLELLKEATKRDLNLSDED------------GMTPTLLAAYHGNLEALEIICS 53
H AA + + ++ + + + +ED GM LL+A+ G+L L+I+ +
Sbjct: 53 HWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVN 112
Query: 54 RGGDPDRCDIWGNTPLHFAASNGHAHCVSFLV 85
G G T LH AA GH ++F++
Sbjct: 113 SGAKIHCESKDGLTLLHCAAQKGHVPVLAFIM 144
Score = 30.0 bits (66), Expect = 4.1
Identities = 18/62 (29%), Positives = 27/62 (43%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
D+N D TP LAA H + +++ G D + D G T L A + H V
Sbjct: 316 DVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDM 375
Query: 84 LV 85
++
Sbjct: 376 II 377
>gi|118498337 HECT domain containing 1 [Homo sapiens]
Length = 2610
Score = 59.3 bits (142), Expect = 6e-09
Identities = 45/144 (31%), Positives = 69/144 (47%), Gaps = 9/144 (6%)
Query: 24 DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSF 83
++N D+ G T A+ G E +E +C RG D +R ++ LH+AA G
Sbjct: 388 EVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVNRGQ--RSSSLHYAACFGRPQVAKT 445
Query: 84 LVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNA 143
L+ GAN D D +TPLD A R +E VA+L + M P V + ++ +K+
Sbjct: 446 LLRHGANPDLRDEDGKTPLDKARERGHSEVVAILQSPG---DWMCP--VNKGDDKKKKDT 500
Query: 144 RRQIKECERLQEKHQNKMAHTYSK 167
+ +EC + K +MA Y K
Sbjct: 501 NKDEEECN--EPKGDPEMAPIYLK 522
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 59.3 bits (142), Expect = 6e-09
Identities = 47/185 (25%), Positives = 84/185 (45%), Gaps = 20/185 (10%)
Query: 3 TRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
T H A ++ + E++ R LN+ D + T + A + I+ G DP+
Sbjct: 82 TALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNL 141
Query: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
D+ GNT LH+A N + L+ + ANI A + D TPL A S ++ + V L
Sbjct: 142 ADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFL--- 198
Query: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTL-SSSKGT 179
+K++A NA +++ +L +++ + +S + S ++ SS+ +
Sbjct: 199 --------------IKKKANVNAVDKLESSHQLISEYKEERIPKHSSQNSNSVDESSEDS 244
Query: 180 FSRSS 184
SR S
Sbjct: 245 LSRLS 249
Score = 40.4 bits (93), Expect = 0.003
Identities = 25/81 (30%), Positives = 41/81 (50%), Gaps = 3/81 (3%)
Query: 39 AAYHGNLEALE--IICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDN 96
AA GN+ ++ ++ + G DR D T LH A +NGH V+ LV+ + DN
Sbjct: 53 AASAGNVAKVQQILLLRKNGLNDR-DKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDN 111
Query: 97 DLQTPLDAAASREQNECVALL 117
+ +T L A ++ +C +L
Sbjct: 112 ENRTALMKAVQCQEEKCATIL 132
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 58.9 bits (141), Expect = 8e-09
Identities = 34/109 (31%), Positives = 55/109 (50%), Gaps = 2/109 (1%)
Query: 8 AASDSYLELLKEATKRDLNLSDED--GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWG 65
A+ + ++ +++E K +NL D G T + A Y G + +E++ S G +P ++
Sbjct: 78 ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137
Query: 66 NTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECV 114
P+ +AA GHA V L+ GA + D TPL AA + ECV
Sbjct: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECV 186
Score = 46.6 bits (109), Expect = 4e-05
Identities = 30/95 (31%), Positives = 48/95 (50%)
Query: 23 RDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVS 82
+D++ +E G TP ++AA GNLE ++ + G + + D+ T L A+ GH H V
Sbjct: 29 KDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVE 88
Query: 83 FLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
L+ G N+ D T L A + + + V LL
Sbjct: 89 ELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELL 123
Score = 45.8 bits (107), Expect = 7e-05
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 2/111 (1%)
Query: 16 LLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASN 75
LL+ K +N SD+ G TP + AA G+LE ++ + + G D D+ T L A
Sbjct: 156 LLQNGAK--VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKG 213
Query: 76 GHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNI 126
G+ V ++ N+ D D T L A+ E V L A T NI
Sbjct: 214 GYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI 264
Score = 42.0 bits (97), Expect = 0.001
Identities = 30/97 (30%), Positives = 48/97 (49%), Gaps = 2/97 (2%)
Query: 8 AASDSYLELLKEATKRD--LNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWG 65
A Y + +KE KR+ +NL+D+DG T ++A+ G+ E ++ + G + D G
Sbjct: 210 AVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSG 269
Query: 66 NTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPL 102
+T L A GH V L+ A+I D +T L
Sbjct: 270 DTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTAL 306
Score = 39.3 bits (90), Expect = 0.007
Identities = 35/117 (29%), Positives = 52/117 (44%), Gaps = 3/117 (2%)
Query: 8 AASDSYLELLKE--ATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWG 65
AA +LE +K A D++ + MT ++A G ++++ I R + + D G
Sbjct: 177 AARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDG 236
Query: 66 NTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECV-ALLDKAA 121
NT L A+ GH V L++ G + D T L A E V ALL K A
Sbjct: 237 NTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYA 293
Score = 38.9 bits (89), Expect = 0.009
Identities = 28/112 (25%), Positives = 47/112 (41%), Gaps = 2/112 (1%)
Query: 8 AASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWG 65
A ++E+++ ++ D+++ +D T A GN + I D + C G
Sbjct: 276 AVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDG 335
Query: 66 NTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
TPL A + V L++ GA + A+D TPL A + LL
Sbjct: 336 ETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELL 387
Score = 34.3 bits (77), Expect = 0.22
Identities = 22/63 (34%), Positives = 31/63 (49%)
Query: 44 NLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLD 103
N+ AL+ + + D D + G TPL AA G+ V L+ GAN D D T L
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 104 AAA 106
+A+
Sbjct: 77 SAS 79
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 58.9 bits (141), Expect = 8e-09
Identities = 41/113 (36%), Positives = 55/113 (48%), Gaps = 3/113 (2%)
Query: 8 AASDSYLELLKEATKRD-LNLSDEDGM--TPTLLAAYHGNLEALEIICSRGGDPDRCDIW 64
AA L +K+ + D +N D G TP LAA + NLE E + G D + D
Sbjct: 652 AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711
Query: 65 GNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
G PLH AAS GH + L+ + A + A D TPL AA + + + ALL
Sbjct: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALL 764
Score = 54.7 bits (130), Expect = 2e-07
Identities = 36/138 (26%), Positives = 67/138 (48%), Gaps = 2/138 (1%)
Query: 2 STRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
ST H AA + +++++ + D++ D+ + P A +G+ E E++ G +
Sbjct: 212 STPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVN 271
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDK 119
D+W TPLH AAS S L+++GA+ L+ ++ +D A + + E +A K
Sbjct: 272 AMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFK 331
Query: 120 AATAQNIMNPKKVTRLKE 137
+ VTR+K+
Sbjct: 332 GHSLLQAAREADVTRIKK 349
Score = 54.7 bits (130), Expect = 2e-07
Identities = 60/240 (25%), Positives = 101/240 (42%), Gaps = 24/240 (10%)
Query: 2 STRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
ST H AA + LE+ + + D+N D+ G+ P AA +G+++ ++ +
Sbjct: 680 STPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVN 739
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDK 119
D W TPLH AA G + L+ GA+ + + QTPLD ++ ++ ALL
Sbjct: 740 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA---DDVSALLTA 796
Query: 120 AATAQNIMNPKKV-TRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKG 178
A M P + + K Q R + L + S + +L + G
Sbjct: 797 A------MPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPS----SLSAASSLDNLSG 846
Query: 179 TFSRSSPSNASAPGTFGSLSKGIKDTFKIKFKKNKDTAEQVGKEGRSGQRNVMEVFREEE 238
+FS S S S+ GT G+ S K+ + F + G ++M++F E+
Sbjct: 847 SFSELS-SVVSSSGTEGASSLEKKEVPGVDFSITQFVR-------NLGLEHLMDIFEREQ 898
Score = 52.0 bits (123), Expect = 1e-06
Identities = 43/137 (31%), Positives = 65/137 (47%), Gaps = 7/137 (5%)
Query: 7 QAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWG- 65
Q +++ +LL+E ++L + + L AA G++E ++ +C+ R DI G
Sbjct: 471 QMGNENVQQLLQEG----ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCR-DIEGR 525
Query: 66 -NTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQ 124
+TPLHFAA V +L+ GA++ A D PL A S E LL K
Sbjct: 526 QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVV 585
Query: 125 NIMNPKKVTRLKEQAQK 141
N+ + K T L E A K
Sbjct: 586 NVADLWKFTPLHEAAAK 602
Score = 51.6 bits (122), Expect = 1e-06
Identities = 31/104 (29%), Positives = 51/104 (49%), Gaps = 2/104 (1%)
Query: 2 STRYHQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
ST H AA + + +++ + D++ D+ G+ P A +G+ E E++ G +
Sbjct: 527 STPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN 586
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLD 103
D+W TPLH AA+ G L+ GA+ + D TPLD
Sbjct: 587 VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLD 630
Score = 50.8 bits (120), Expect = 2e-06
Identities = 40/119 (33%), Positives = 56/119 (47%), Gaps = 4/119 (3%)
Query: 7 QAASDSYLELLKE-ATKRDLNLSDEDGM--TPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
+A + +E +K T +N D G TP AA G + +E + G + D
Sbjct: 30 EACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPL-DAAASREQNECVALLDKAA 121
G PLH A S GHA V+ L+ GA+ A DN TPL +AA + + C+ LL A
Sbjct: 90 GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGA 148
Score = 50.8 bits (120), Expect = 2e-06
Identities = 37/123 (30%), Positives = 57/123 (46%), Gaps = 2/123 (1%)
Query: 8 AASDSYLELLKEATKRDLNLSDEDGM--TPTLLAAYHGNLEALEIICSRGGDPDRCDIWG 65
A S + +++ T ++N DG TP LAA + ++ ++++ G D D
Sbjct: 185 ARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGD 244
Query: 66 NTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQN 125
PLH A S GH LV GA + A+D TPL AAS+ + E +LL
Sbjct: 245 LVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPT 304
Query: 126 IMN 128
++N
Sbjct: 305 LLN 307
Score = 48.9 bits (115), Expect = 8e-06
Identities = 32/106 (30%), Positives = 48/106 (45%), Gaps = 2/106 (1%)
Query: 2 STRYHQAASDSYLELLKEATKRDLNLS--DEDGMTPTLLAAYHGNLEALEIICSRGGDPD 59
ST H AA ++++ + N+ D+ G+ P A G+ E + ++ G DP+
Sbjct: 59 STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118
Query: 60 RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAA 105
D W TPLH AA G L+ GA + D +T LD A
Sbjct: 119 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
Score = 48.5 bits (114), Expect = 1e-05
Identities = 37/114 (32%), Positives = 52/114 (45%), Gaps = 3/114 (2%)
Query: 7 QAASDSYLELLKE-ATKRDLNLSDEDGM--TPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
+AA +E +K+ T + +N D +G TP AA + + +E + G D D
Sbjct: 498 EAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDK 557
Query: 64 WGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL 117
G PLH A S GH LV GA + D TPL AA++ + E LL
Sbjct: 558 GGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611
Score = 43.1 bits (100), Expect = 5e-04
Identities = 28/77 (36%), Positives = 34/77 (44%)
Query: 66 NTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQN 125
+TPLH AA V L+ GA++ A D PL A S E LL K N
Sbjct: 212 STPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVN 271
Query: 126 IMNPKKVTRLKEQAQKN 142
M+ + T L E A KN
Sbjct: 272 AMDLWQFTPLHEAASKN 288
Score = 41.6 bits (96), Expect = 0.001
Identities = 29/76 (38%), Positives = 36/76 (47%)
Query: 66 NTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQN 125
+TPLHFAA G V +L+ GAN+ A D+ PL A S E V LL + N
Sbjct: 59 STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118
Query: 126 IMNPKKVTRLKEQAQK 141
+ T L E A K
Sbjct: 119 ARDNWNYTPLHEAAIK 134
Score = 35.8 bits (81), Expect = 0.074
Identities = 36/148 (24%), Positives = 65/148 (43%), Gaps = 20/148 (13%)
Query: 3 TRYHQAASDSYLE-------LLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRG 55
T H AA+ Y + LL++ ++N ++ +TP +A+ + + +E++
Sbjct: 366 TALHCAAASPYPKRKQICELLLRKGA--NINEKTKEFLTPLHVASEKAHNDVVEVVVKHE 423
Query: 56 GDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGA--NIFAL---------DNDLQTPLDA 104
+ D G T LH AA GH L+++G NI +L + ++Q L
Sbjct: 424 AKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQE 483
Query: 105 AASREQNECVALLDKAATAQNIMNPKKV 132
S +E L +AA A ++ KK+
Sbjct: 484 GISLGNSEADRQLLEAAKAGDVETVKKL 511
Score = 35.0 bits (79), Expect = 0.13
Identities = 26/83 (31%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 67 TPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNI 126
TPLH A+ H V +V A + ALDN QT L AA + LL NI
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 127 MNPKKVTRLKEQAQKNARRQIKE 149
++ + T L + +N ++ ++E
Sbjct: 462 ISLQGFTAL-QMGNENVQQLLQE 483
Score = 31.2 bits (69), Expect = 1.8
Identities = 17/52 (32%), Positives = 30/52 (57%), Gaps = 1/52 (1%)
Query: 351 FLLSQHLEEFLPIFKREQIDLEALLLCSDEDLQSIQMQ-LGPRKKVLNAINR 401
F+ + LE + IF+REQI L+ L+ ++L+ I + G R K++ + R
Sbjct: 881 FVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVER 932
Score = 29.3 bits (64), Expect = 6.9
Identities = 31/135 (22%), Positives = 45/135 (33%), Gaps = 23/135 (17%)
Query: 6 HQAASDSYLELLKEATKR--DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDI 63
H A S + E++ + D N D TP AA G ++ ++ G +P +
Sbjct: 96 HNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNT 155
Query: 64 WGNTPLHF---------------------AASNGHAHCVSFLVNFGANIFALDNDLQTPL 102
G T L A S ++ L N A D TPL
Sbjct: 156 DGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPL 215
Query: 103 DAAASREQNECVALL 117
AA + + V LL
Sbjct: 216 HLAAGYNRVKIVQLL 230
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,307,815
Number of Sequences: 37866
Number of extensions: 770679
Number of successful extensions: 5712
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 342
Number of HSP's successfully gapped in prelim test: 174
Number of HSP's that attempted gapping in prelim test: 3375
Number of HSP's gapped (non-prelim): 1886
length of query: 417
length of database: 18,247,518
effective HSP length: 105
effective length of query: 312
effective length of database: 14,271,588
effective search space: 4452735456
effective search space used: 4452735456
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.