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Search of human proteins with 148612853
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148612853 ATP-binding cassette, sub-family F (GCN20), member
3 [Homo sapiens]
(709 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148612853 ATP-binding cassette, sub-family F (GCN20), member ... 1393 0.0
gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform... 441 e-123
gi|10947135 ATP-binding cassette, sub-family F, member 1 isoform... 439 e-123
gi|27881506 ATP-binding cassette, sub-family F, member 2 isoform... 420 e-117
gi|10947137 ATP-binding cassette, sub-family F, member 2 isoform... 420 e-117
gi|108773784 ATP-binding cassette, sub-family E, member 1 [Homo ... 66 1e-10
gi|108773782 ATP-binding cassette, sub-family E, member 1 [Homo ... 66 1e-10
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 59 2e-08
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 58 3e-08
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 57 8e-08
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 55 2e-07
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 55 2e-07
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 55 3e-07
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 53 9e-07
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 53 9e-07
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 53 9e-07
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 52 2e-06
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 52 2e-06
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 51 3e-06
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 51 3e-06
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 51 3e-06
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 50 6e-06
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 50 6e-06
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 50 7e-06
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 50 7e-06
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 49 1e-05
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 49 1e-05
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 49 1e-05
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 49 2e-05
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 49 2e-05
>gi|148612853 ATP-binding cassette, sub-family F (GCN20), member 3
[Homo sapiens]
Length = 709
Score = 1393 bits (3605), Expect = 0.0
Identities = 709/709 (100%), Positives = 709/709 (100%)
Query: 1 MATCAEILRSEFPEIDGQVFDYVTGVLHSGSADFESVDDLVEAVGELLQEVSGDSKDDAG 60
MATCAEILRSEFPEIDGQVFDYVTGVLHSGSADFESVDDLVEAVGELLQEVSGDSKDDAG
Sbjct: 1 MATCAEILRSEFPEIDGQVFDYVTGVLHSGSADFESVDDLVEAVGELLQEVSGDSKDDAG 60
Query: 61 IRAVCQRMYNTLRLAEPQSQGNSQVLLDAPIQLSKITENYDCGTKLPGLLKREQSSTVNA 120
IRAVCQRMYNTLRLAEPQSQGNSQVLLDAPIQLSKITENYDCGTKLPGLLKREQSSTVNA
Sbjct: 61 IRAVCQRMYNTLRLAEPQSQGNSQVLLDAPIQLSKITENYDCGTKLPGLLKREQSSTVNA 120
Query: 121 KKLEKAEARLKAKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRLESSGKNKSYDVRI 180
KKLEKAEARLKAKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRLESSGKNKSYDVRI
Sbjct: 121 KKLEKAEARLKAKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRLESSGKNKSYDVRI 180
Query: 181 ENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVE 240
ENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVE
Sbjct: 181 ENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVE 240
Query: 241 QEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEA 300
QEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEA
Sbjct: 241 QEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEA 300
Query: 301 DKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDV 360
DKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDV
Sbjct: 301 DKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDV 360
Query: 361 RAILWLENYLQTWPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERL 420
RAILWLENYLQTWPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERL
Sbjct: 361 RAILWLENYLQTWPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERL 420
Query: 421 LNQQREYEAQQQYRQHIQVFIDRFRYNANRASQVQSKLKMLEKLPELKPVDKESEVVMKF 480
LNQQREYEAQQQYRQHIQVFIDRFRYNANRASQVQSKLKMLEKLPELKPVDKESEVVMKF
Sbjct: 421 LNQQREYEAQQQYRQHIQVFIDRFRYNANRASQVQSKLKMLEKLPELKPVDKESEVVMKF 480
Query: 481 PDGFEKFSPPILQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLG 540
PDGFEKFSPPILQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLG
Sbjct: 481 PDGFEKFSPPILQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLG 540
Query: 541 DLAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPGRPEEEYRHQLGRYGIS 600
DLAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPGRPEEEYRHQLGRYGIS
Sbjct: 541 DLAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPGRPEEEYRHQLGRYGIS 600
Query: 601 GELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGGV 660
GELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGGV
Sbjct: 601 GELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGGV 660
Query: 661 ILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQYRALLQEQFRREGFL 709
ILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQYRALLQEQFRREGFL
Sbjct: 661 ILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQYRALLQEQFRREGFL 709
>gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform a
[Homo sapiens]
Length = 845
Score = 441 bits (1134), Expect = e-123
Identities = 246/587 (41%), Positives = 353/587 (60%), Gaps = 27/587 (4%)
Query: 124 EKAEARLKAKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRLESSGKNKSYDVRIENF 183
+K + +LK + E + +LK +N + + + S +++ LE++ D+++E F
Sbjct: 255 KKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENAS-----DIKLEKF 309
Query: 184 DVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEV 243
+S + L AD+ + GRRYGLVG NG GKTTLLK +A R+L +P +I +L EQEV
Sbjct: 310 SISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEV 369
Query: 244 AGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKA 303
D+TPA+Q+VL +D+ R LL ER L Q+ G + + A L ++Y +L A A
Sbjct: 370 VADETPAVQAVLRADTKRLKLLEEERRLQGQLEQG--DDTAAERLEKVYEELRATGAAAA 427
Query: 304 PARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAI 363
A+A ILAGLGF P+MQ +PT++FSGGWRMR++LARALF P LL+LDEPTN LD+ A+
Sbjct: 428 EAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAV 487
Query: 364 LWLENYLQTWPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQ 423
+WL NYLQ W T+L+VSHD+ FL+ + TDIIHL +QRL YRG++ TF K Q++
Sbjct: 488 IWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKEL 547
Query: 424 QREYEAQQ--------------QYRQHIQVFIDRFRYNANRASQVQSKLKMLEKLPELKP 469
++YE Q+ Q + + + R + R +Q + ++ PEL
Sbjct: 548 LKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEES----QEAPELLK 603
Query: 470 VDKESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGA 529
KE V FPD SPP+L L V F Y + +F L D++SRIC+VG NG
Sbjct: 604 RPKEYTVRFTFPDP-PPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGV 662
Query: 530 GKSTMLKLLLGDLAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPGRPEEE 589
GKST+L LL G L P G + LKIG+F+Q + EQL + + E L R F P ++
Sbjct: 663 GKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGF-NLPYQD 721
Query: 590 YRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEAL 649
R LGR+G+ + LSGGQK+RV FA++ P+ ILDEPTN+LD+E+I+AL
Sbjct: 722 ARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDAL 781
Query: 650 GRALNNFRGGVILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQYR 696
G A+N ++G VI+VSHD R I +LWV E V++++G F+ Y+
Sbjct: 782 GEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYK 828
Score = 68.6 bits (166), Expect = 2e-11
Identities = 76/320 (23%), Positives = 133/320 (41%), Gaps = 59/320 (18%)
Query: 413 IKSKQERLLNQQREYEAQQQYRQHIQVFIDRFRYNANRASQVQSKLKMLEKLPELKPVDK 472
+ K+++ L +Q EYE Q + + F + +++ S+ MLE ++K
Sbjct: 253 LSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQ---AEMSSRQAMLENASDIK---- 305
Query: 473 ESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAGKS 532
EKFS I + F +++ R R +VG NG GK+
Sbjct: 306 -----------LEKFS--ISAHGKELFVNADLYIVAGR---------RYGLVGPNGKGKT 343
Query: 533 TMLKLL--------------------LGDLAP-VRGIRHAH-RNLKIGYFSQHHVEQLDL 570
T+LK + + D P V+ + A + LK+ + QL+
Sbjct: 344 TLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQ 403
Query: 571 -NVSAVELLARKFP-------GRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFA 622
+ +A E L + + E + R L G E+ RP SGG + RV+ A
Sbjct: 404 GDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLA 463
Query: 623 QMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGGVILVSHDERFIRLVCRELWVCEG 682
+ P +LDEPTNHLD+ + L L +R +++VSHD+ F+ VC ++ +
Sbjct: 464 RALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDA 523
Query: 683 GGVTRVEGGFDQYRALLQEQ 702
+ G + ++ + Q++
Sbjct: 524 QRLHYYRGNYMTFKKMYQQK 543
Score = 65.1 bits (157), Expect = 2e-10
Identities = 77/323 (23%), Positives = 118/323 (36%), Gaps = 59/323 (18%)
Query: 121 KKLEKAEARLK-----AKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRL--ESSGKN 173
K+ EK E +LK K K++EK +T L ++ + +ES+ E +
Sbjct: 549 KQYEKQEKKLKELKAGGKSTKQAEK---QTKEALTRKQQKCRRKNQDEESQEAPELLKRP 605
Query: 174 KSYDVRIENFD-------------VSFG---DRVLLAGADVNLAWGRRYGLVGRNGLGKT 217
K Y VR D V+FG + L D + R +VG NG+GK+
Sbjct: 606 KEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGVGKS 665
Query: 218 TLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAA 277
TLL +L + P H + + G L + + L+R L Q
Sbjct: 666 TLLLLLTGKL--TPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQ--- 720
Query: 278 GRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLA 337
A L G + SGG + R+
Sbjct: 721 ----------------------------DARKCLGRFGLESHAHTIQICKLSGGQKARVV 752
Query: 338 LARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPSTILVVSHDRNFLNAIATDIIHL 397
A PD+L+LDEPTN LD+ +I L + + ++VVSHD + + +
Sbjct: 753 FAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVV 812
Query: 398 HSQRLDGYRGDFETFIKSKQERL 420
Q + GDFE + + E L
Sbjct: 813 EEQSVSQIDGDFEDYKREVLEAL 835
>gi|10947135 ATP-binding cassette, sub-family F, member 1 isoform b
[Homo sapiens]
Length = 807
Score = 439 bits (1129), Expect = e-123
Identities = 248/602 (41%), Positives = 358/602 (59%), Gaps = 32/602 (5%)
Query: 109 LLKREQSSTVNAKKLEKAEARLKAKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRLE 168
++K ++ +K +KAE + E + +LK +N + + + S +++ LE
Sbjct: 207 IIKEKEPPKQGKEKAKKAE-----QMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLE 261
Query: 169 SSGKNKSYDVRIENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSL 228
++ D+++E F +S + L AD+ + GRRYGLVG NG GKTTLLK +A R+L
Sbjct: 262 NAS-----DIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRAL 316
Query: 229 RVPAHISLLHVEQEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAEL 288
+P +I +L EQEV D+TPA+Q+VL +D+ R LL ER L Q+ G + + A L
Sbjct: 317 SIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQG--DDTAAERL 374
Query: 289 AEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDL 348
++Y +L A A A+A ILAGLGF P+MQ +PT++FSGGWRMR++LARALF P L
Sbjct: 375 EKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTL 434
Query: 349 LLLDEPTNMLDVRAILWLENYLQTWPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGD 408
L+LDEPTN LD+ A++WL NYLQ W T+L+VSHD+ FL+ + TDIIHL +QRL YRG+
Sbjct: 435 LMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGN 494
Query: 409 FETFIKSKQERLLNQQREYEAQQ--------------QYRQHIQVFIDRFRYNANRASQV 454
+ TF K Q++ ++YE Q+ Q + + + R + R +Q
Sbjct: 495 YMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQD 554
Query: 455 QSKLKMLEKLPELKPVDKESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKHVIFSRLSVS 514
+ ++ PEL KE V FPD SPP+L L V F Y + +F L
Sbjct: 555 EES----QEAPELLKRPKEYTVRFTFPDP-PPLSPPVLGLHGVTFGYQGQKPLFKNLDFG 609
Query: 515 ADLESRICVVGENGAGKSTMLKLLLGDLAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSA 574
D++SRIC+VG NG GKST+L LL G L P G + LKIG+F+Q + EQL + +
Sbjct: 610 IDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETP 669
Query: 575 VELLARKFPGRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYIL 634
E L R F P ++ R LGR+G+ + LSGGQK+RV FA++ P+ IL
Sbjct: 670 TEYLQRGF-NLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLIL 728
Query: 635 DEPTNHLDMETIEALGRALNNFRGGVILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQ 694
DEPTN+LD+E+I+ALG A+N ++G VI+VSHD R I +LWV E V++++G F+
Sbjct: 729 DEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFED 788
Query: 695 YR 696
Y+
Sbjct: 789 YK 790
Score = 67.8 bits (164), Expect = 3e-11
Identities = 61/226 (26%), Positives = 101/226 (44%), Gaps = 34/226 (15%)
Query: 511 LSVSADLE----SRICVVGENGAGKSTMLKLL--------------------LGDLAP-V 545
L V+ADL R +VG NG GK+T+LK + + D P V
Sbjct: 280 LFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAV 339
Query: 546 RGIRHAH-RNLKIGYFSQHHVEQLDL-NVSAVELLARKFP-------GRPEEEYRHQLGR 596
+ + A + LK+ + QL+ + +A E L + + E + R L
Sbjct: 340 QAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAG 399
Query: 597 YGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNF 656
G E+ RP SGG + RV+ A+ P +LDEPTNHLD+ + L L +
Sbjct: 400 LGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGW 459
Query: 657 RGGVILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQYRALLQEQ 702
R +++VSHD+ F+ VC ++ + + G + ++ + Q++
Sbjct: 460 RKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQK 505
Score = 65.1 bits (157), Expect = 2e-10
Identities = 77/323 (23%), Positives = 118/323 (36%), Gaps = 59/323 (18%)
Query: 121 KKLEKAEARLK-----AKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRL--ESSGKN 173
K+ EK E +LK K K++EK +T L ++ + +ES+ E +
Sbjct: 511 KQYEKQEKKLKELKAGGKSTKQAEK---QTKEALTRKQQKCRRKNQDEESQEAPELLKRP 567
Query: 174 KSYDVRIENFD-------------VSFG---DRVLLAGADVNLAWGRRYGLVGRNGLGKT 217
K Y VR D V+FG + L D + R +VG NG+GK+
Sbjct: 568 KEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGVGKS 627
Query: 218 TLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAA 277
TLL +L + P H + + G L + + L+R L Q
Sbjct: 628 TLLLLLTGKL--TPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQ--- 682
Query: 278 GRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLA 337
A L G + SGG + R+
Sbjct: 683 ----------------------------DARKCLGRFGLESHAHTIQICKLSGGQKARVV 714
Query: 338 LARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPSTILVVSHDRNFLNAIATDIIHL 397
A PD+L+LDEPTN LD+ +I L + + ++VVSHD + + +
Sbjct: 715 FAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVV 774
Query: 398 HSQRLDGYRGDFETFIKSKQERL 420
Q + GDFE + + E L
Sbjct: 775 EEQSVSQIDGDFEDYKREVLEAL 797
>gi|27881506 ATP-binding cassette, sub-family F, member 2 isoform a
[Homo sapiens]
Length = 623
Score = 420 bits (1080), Expect = e-117
Identities = 237/582 (40%), Positives = 357/582 (61%), Gaps = 15/582 (2%)
Query: 127 EARLKAKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRLESSGKNKSYDVRIENFDVS 186
E ++ K E + T LE+ +A +R + + +S N S DV I N ++
Sbjct: 36 EPQVAEKNEANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPN-STDVHIINLSLT 94
Query: 187 FGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGD 246
F + LL+ + L GRRYGL+G NG+GK+ LL + R + +P HI + H+ +E+
Sbjct: 95 FHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPS 154
Query: 247 DTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPAR 306
D L V+E D+ R +L +E E A E +E +L E+Y +LEE++ADKA R
Sbjct: 155 DKTPLHCVMEVDTERA-MLEKEAERLAH------EDAECEKLMELYERLEELDADKAEMR 207
Query: 307 ASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWL 366
AS IL GLGFTP MQ++ ++FSGGWRMR+ALARALF RP +LLLDEPTN LD+ A +WL
Sbjct: 208 ASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWL 267
Query: 367 ENYLQTWPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQQRE 426
E L+T+ +++VSH ++FLN + T+IIH+H+++L Y G+++ ++K++ E NQ +
Sbjct: 268 EEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKR 327
Query: 427 YEAQQQYRQHIQVFIDRFRY-NANRASQVQSKLKMLEKLPE---LKPVDKESEVVMKFPD 482
+ +Q H++ +I RF + +A A Q QSK K L+K+ + V + + FP
Sbjct: 328 FHWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPP 387
Query: 483 GFEKFSPPILQLDEVDFYYDPK-HVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGD 541
K PP++ + V F Y I++ L DL++R+ +VG NGAGKST+LKLL G+
Sbjct: 388 -CGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGE 446
Query: 542 LAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPG-RPEEEYRHQLGRYGIS 600
L P G+ H ++KIG + QH EQLDL++S +E + + +P + +EE R +GRYG++
Sbjct: 447 LLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLT 506
Query: 601 GELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGGV 660
G+ + P+ +LS GQK RV A + P+ LDEPTNHLD+ETI+AL A+N F GG+
Sbjct: 507 GKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGM 566
Query: 661 ILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQYRALLQEQ 702
+LVSHD R I+ V +E+WVCE +T+ G Y+ L+ +
Sbjct: 567 MLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSK 608
Score = 71.6 bits (174), Expect = 2e-12
Identities = 59/226 (26%), Positives = 96/226 (42%), Gaps = 43/226 (19%)
Query: 205 RYGLVGRNGLGKTTLLKMLATRSL------RVPAHISLLHVEQEVAGDDTPALQSVLESD 258
R LVG NG GK+TLLK+L L R +H+ + Q LQ L+ D
Sbjct: 425 RVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQH--------LQEQLDLD 476
Query: 259 SVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTP 318
S + + Y +++E E + I+ G T
Sbjct: 477 L-----------------------SPLEYMMKCYPEIKEKEEMRK------IIGRYGLTG 507
Query: 319 KMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPSTIL 378
K Q P R S G + R+ LA + P +L LDEPTN LD+ I L + + + ++
Sbjct: 508 KQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMM 567
Query: 379 VVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQQ 424
+VSHD + +A +I Q + + GD + + + +L++++
Sbjct: 568 LVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKLVDEE 613
>gi|10947137 ATP-binding cassette, sub-family F, member 2 isoform b
[Homo sapiens]
Length = 634
Score = 420 bits (1080), Expect = e-117
Identities = 237/582 (40%), Positives = 357/582 (61%), Gaps = 15/582 (2%)
Query: 127 EARLKAKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRLESSGKNKSYDVRIENFDVS 186
E ++ K E + T LE+ +A +R + + +S N S DV I N ++
Sbjct: 36 EPQVAEKNEANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPN-STDVHIINLSLT 94
Query: 187 FGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGD 246
F + LL+ + L GRRYGL+G NG+GK+ LL + R + +P HI + H+ +E+
Sbjct: 95 FHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPS 154
Query: 247 DTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPAR 306
D L V+E D+ R +L +E E A E +E +L E+Y +LEE++ADKA R
Sbjct: 155 DKTPLHCVMEVDTERA-MLEKEAERLAH------EDAECEKLMELYERLEELDADKAEMR 207
Query: 307 ASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWL 366
AS IL GLGFTP MQ++ ++FSGGWRMR+ALARALF RP +LLLDEPTN LD+ A +WL
Sbjct: 208 ASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWL 267
Query: 367 ENYLQTWPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQQRE 426
E L+T+ +++VSH ++FLN + T+IIH+H+++L Y G+++ ++K++ E NQ +
Sbjct: 268 EEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKR 327
Query: 427 YEAQQQYRQHIQVFIDRFRY-NANRASQVQSKLKMLEKLPE---LKPVDKESEVVMKFPD 482
+ +Q H++ +I RF + +A A Q QSK K L+K+ + V + + FP
Sbjct: 328 FHWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPP 387
Query: 483 GFEKFSPPILQLDEVDFYYDPK-HVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGD 541
K PP++ + V F Y I++ L DL++R+ +VG NGAGKST+LKLL G+
Sbjct: 388 -CGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGE 446
Query: 542 LAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPG-RPEEEYRHQLGRYGIS 600
L P G+ H ++KIG + QH EQLDL++S +E + + +P + +EE R +GRYG++
Sbjct: 447 LLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLT 506
Query: 601 GELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGGV 660
G+ + P+ +LS GQK RV A + P+ LDEPTNHLD+ETI+AL A+N F GG+
Sbjct: 507 GKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGM 566
Query: 661 ILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQYRALLQEQ 702
+LVSHD R I+ V +E+WVCE +T+ G Y+ L+ +
Sbjct: 567 MLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSK 608
Score = 71.6 bits (174), Expect = 2e-12
Identities = 59/226 (26%), Positives = 96/226 (42%), Gaps = 43/226 (19%)
Query: 205 RYGLVGRNGLGKTTLLKMLATRSL------RVPAHISLLHVEQEVAGDDTPALQSVLESD 258
R LVG NG GK+TLLK+L L R +H+ + Q LQ L+ D
Sbjct: 425 RVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQH--------LQEQLDLD 476
Query: 259 SVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTP 318
S + + Y +++E E + I+ G T
Sbjct: 477 L-----------------------SPLEYMMKCYPEIKEKEEMRK------IIGRYGLTG 507
Query: 319 KMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPSTIL 378
K Q P R S G + R+ LA + P +L LDEPTN LD+ I L + + + ++
Sbjct: 508 KQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMM 567
Query: 379 VVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQQ 424
+VSHD + +A +I Q + + GD + + + +L++++
Sbjct: 568 LVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKLVDEE 613
>gi|108773784 ATP-binding cassette, sub-family E, member 1 [Homo
sapiens]
Length = 599
Score = 66.2 bits (160), Expect = 1e-10
Identities = 119/537 (22%), Positives = 212/537 (39%), Gaps = 103/537 (19%)
Query: 203 GRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAG--DDTPALQSVLE--SD 258
G GLVG NG+GK+T LK+LA + ++ G DD P Q +L
Sbjct: 103 GEVLGLVGTNGIGKSTALKILAGK-------------QKPNLGKYDDPPDWQEILTYFRG 149
Query: 259 SVREDLLRR--ERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGF 316
S ++ + E +L A I + A + + L+ + K A ++ L
Sbjct: 150 SELQNYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQA---IVCQQLDL 206
Query: 317 TPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDV----RAILWLENYLQT 372
T ++++ + SGG R A A + D+ + DEP++ LDV +A + + + +
Sbjct: 207 T-HLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINP 265
Query: 373 WPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQQREYEAQQQ 432
I+VV HD + L+ ++ I L+ + +
Sbjct: 266 -DRYIIVVEHDLSVLDYLSDFICCLYG--------------------VPSAYGVVTMPFS 304
Query: 433 YRQHIQVFIDRFRYNANRASQVQSKLKMLEKLPELKPVDKESEVVM-KFPDGFEKFSPPI 491
R+ I +F+D + N + S ++ K+ E ++ ++ M K+P +K
Sbjct: 305 VREGINIFLDGYVPTENLRFRDAS---LVFKVAETANEEEVKKMCMYKYPGMKKKMGEFE 361
Query: 492 LQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRG---- 547
L + +F D E + ++GENG GK+T +++L G L P G
Sbjct: 362 LAIVAGEF---------------TDSEIMV-MLGENGTGKTTFIRMLAGRLKPDEGGEVP 405
Query: 548 -IRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPGRPEEEYRHQLGRYGISGELAM- 605
+ +++ KI S V Q LL K + Y H + L +
Sbjct: 406 VLNVSYKPQKISPKSTGSVRQ---------LLHEKI----RDAYTHPQFVTDVMKPLQIE 452
Query: 606 ----RPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNF----R 657
+ + +LSGG+ RVA A + Y++DEP+ +LD E R + F +
Sbjct: 453 NIIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAK 512
Query: 658 GGVILVSHDERFIRLVCRELWVCEG--------GGVTRVEGGFDQYRALLQEQFRRE 706
+V HD + + V +G + G +++ + L+ FRR+
Sbjct: 513 KTAFVVEHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEITFRRD 569
>gi|108773782 ATP-binding cassette, sub-family E, member 1 [Homo
sapiens]
Length = 599
Score = 66.2 bits (160), Expect = 1e-10
Identities = 119/537 (22%), Positives = 212/537 (39%), Gaps = 103/537 (19%)
Query: 203 GRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAG--DDTPALQSVLE--SD 258
G GLVG NG+GK+T LK+LA + ++ G DD P Q +L
Sbjct: 103 GEVLGLVGTNGIGKSTALKILAGK-------------QKPNLGKYDDPPDWQEILTYFRG 149
Query: 259 SVREDLLRR--ERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGF 316
S ++ + E +L A I + A + + L+ + K A ++ L
Sbjct: 150 SELQNYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQA---IVCQQLDL 206
Query: 317 TPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDV----RAILWLENYLQT 372
T ++++ + SGG R A A + D+ + DEP++ LDV +A + + + +
Sbjct: 207 T-HLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINP 265
Query: 373 WPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQQREYEAQQQ 432
I+VV HD + L+ ++ I L+ + +
Sbjct: 266 -DRYIIVVEHDLSVLDYLSDFICCLYG--------------------VPSAYGVVTMPFS 304
Query: 433 YRQHIQVFIDRFRYNANRASQVQSKLKMLEKLPELKPVDKESEVVM-KFPDGFEKFSPPI 491
R+ I +F+D + N + S ++ K+ E ++ ++ M K+P +K
Sbjct: 305 VREGINIFLDGYVPTENLRFRDAS---LVFKVAETANEEEVKKMCMYKYPGMKKKMGEFE 361
Query: 492 LQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRG---- 547
L + +F D E + ++GENG GK+T +++L G L P G
Sbjct: 362 LAIVAGEF---------------TDSEIMV-MLGENGTGKTTFIRMLAGRLKPDEGGEVP 405
Query: 548 -IRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPGRPEEEYRHQLGRYGISGELAM- 605
+ +++ KI S V Q LL K + Y H + L +
Sbjct: 406 VLNVSYKPQKISPKSTGSVRQ---------LLHEKI----RDAYTHPQFVTDVMKPLQIE 452
Query: 606 ----RPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNF----R 657
+ + +LSGG+ RVA A + Y++DEP+ +LD E R + F +
Sbjct: 453 NIIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAK 512
Query: 658 GGVILVSHDERFIRLVCRELWVCEG--------GGVTRVEGGFDQYRALLQEQFRRE 706
+V HD + + V +G + G +++ + L+ FRR+
Sbjct: 513 KTAFVVEHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEITFRRD 569
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 58.5 bits (140), Expect = 2e-08
Identities = 59/207 (28%), Positives = 92/207 (44%), Gaps = 31/207 (14%)
Query: 183 FDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVP----AHISLLH 238
F V DR + ++NL G+ L+G NG GKTT L ML L P A+IS
Sbjct: 539 FRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLT--GLFPPTSGRAYISGYE 596
Query: 239 VEQEVAGDDTPALQSVLESDSVREDL-LRRERELTAQIAAGRAEGSEAAELAEIYAKLEE 297
+ Q++ +R+ L L + ++ + AE YA+L+
Sbjct: 597 ISQDMV--------------QIRKSLGLCPQHDILF-------DNLTVAEHLYFYAQLKG 635
Query: 298 IEADKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNM 357
+ K P +L +G K + +R SGG R +L++ AL A +L+LDEPT+
Sbjct: 636 LSRQKCPEEVKQMLHIIGLEDKWNSR-SRFLSGGMRRKLSIGIALIAGSKVLILDEPTSG 694
Query: 358 LDV--RAILWLENYLQTWPSTILVVSH 382
+D R +W Q TI++ +H
Sbjct: 695 MDAISRRAIWDLLQRQKSDRTIVLTTH 721
Score = 50.1 bits (118), Expect = 7e-06
Identities = 71/281 (25%), Positives = 114/281 (40%), Gaps = 46/281 (16%)
Query: 173 NKSYDVRIENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPA 232
+K Y+ R+ V DR+ LA + G +GL+G NG GKTT KML
Sbjct: 1387 SKVYEQRVPLLAV---DRLSLA-----VQKGECFGLLGFNGAGKTTTFKMLTG------- 1431
Query: 233 HISLLHVEQEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIY 292
E+ + D + SD + +R+ Q A + E+ +Y
Sbjct: 1432 -------EESLTSGDAFVGGHRISSDVGK---VRQRIGYCPQFDA-LLDHMTGREMLVMY 1480
Query: 293 AKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLD 352
A+L I A L GL P + R +SGG + +L+ AL P ++ LD
Sbjct: 1481 ARLRGIPERHIGACVENTLRGLLLEPHANKL-VRTYSGGNKRKLSTGIALIGEPAVIFLD 1539
Query: 353 EPTNMLD--VRAILWLENYLQTWPS--TILVVSHDRNFLNAIATDIIHLHSQRLDGYRGD 408
EP+ +D R +LW + + S I++ SH A+ T + + +G
Sbjct: 1540 EPSTGMDPVARRLLW-DTVARARESGKAIIITSHSMEECEALCTRLAIM-------VQGQ 1591
Query: 409 FETF-----IKSK--QERLLNQQREYEAQQQYRQHIQVFID 442
F+ +KSK L + + E QQ+ + + F+D
Sbjct: 1592 FKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVD 1632
Score = 38.1 bits (87), Expect = 0.028
Identities = 38/159 (23%), Positives = 65/159 (40%), Gaps = 17/159 (10%)
Query: 523 VVGENGAGKSTMLKLLLGDLAPVRGIRH----------AHRNLKIGYFSQHHVEQLDLNV 572
++G NGAGK+T L +L G P G + +G QH + +L V
Sbjct: 564 LLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDNLTV 623
Query: 573 SAVELLARKFPG----RPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPC 628
+ + G + EE + L G+ + R LSGG + +++ +
Sbjct: 624 AEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRS-RFLSGGMRRKLSIGIALIAG 682
Query: 629 PNFYILDEPTNHLDMETIEALGRALNNFRGG--VILVSH 665
ILDEPT+ +D + A+ L + ++L +H
Sbjct: 683 SKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTH 721
Score = 36.6 bits (83), Expect = 0.082
Identities = 57/246 (23%), Positives = 97/246 (39%), Gaps = 36/246 (14%)
Query: 464 LPELKPV-DKESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKHVIFS--RLSVSADLESR 520
LPE + V D+ + ++ PD P++ + E+ Y+ + + + RLS++
Sbjct: 1355 LPEDQDVADERTRILAPSPDSL--LHTPLI-IKELSKVYEQRVPLLAVDRLSLAVQKGEC 1411
Query: 521 ICVVGENGAGKSTMLKLLLGDLAPVRG--IRHAHR--------NLKIGYFSQHHVEQLDL 570
++G NGAGK+T K+L G+ + G HR +IGY Q +
Sbjct: 1412 FGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHM 1471
Query: 571 NVSAVELLARKFPGRPEEEYRHQLGRYGISGELAMRPL----------ASLSGGQKSRVA 620
+ ++ + G PE RH G E +R L + SGG K +++
Sbjct: 1472 TGREMLVMYARLRGIPE---RH----IGACVENTLRGLLLEPHANKLVRTYSGGNKRKLS 1524
Query: 621 FAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFR---GGVILVSHDERFIRLVCREL 677
+ P LDEP+ +D L + R +I+ SH +C L
Sbjct: 1525 TGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRL 1584
Query: 678 WVCEGG 683
+ G
Sbjct: 1585 AIMVQG 1590
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 57.8 bits (138), Expect = 3e-08
Identities = 67/240 (27%), Positives = 99/240 (41%), Gaps = 52/240 (21%)
Query: 460 MLEKLPELKPVDKESEVVMKFPDGFEKFSPPILQLDEVDFYYD--PKHVIFSRLSVSADL 517
+LEK P + +E K PD E L+ EV F+Y P I LS+S +
Sbjct: 546 LLEKKPNIDSRSQEG----KKPDTCEGN----LEFREVSFFYPCRPDVFILRGLSLSIER 597
Query: 518 ESRICVVGENGAGKSTMLKLLLGDLAPVRG------IRHAHRNLK--------------- 556
+ VG +G GKST ++LL PV+G + N++
Sbjct: 598 GKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVL 657
Query: 557 --------IGYFSQHHVEQLD-LNVSAVELLARKFPGRPEEEYRHQLGRYGISGELAMRP 607
I Y V LD + +A F E+Y Q+G G
Sbjct: 658 FNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKG--------- 708
Query: 608 LASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGG--VILVSH 665
A LSGGQK R+A A+ + P +LDE T+ LD ++ + + AL+ R G ++V+H
Sbjct: 709 -AQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTH 767
Score = 51.2 bits (121), Expect = 3e-06
Identities = 68/257 (26%), Positives = 119/257 (46%), Gaps = 42/257 (16%)
Query: 164 ESRLESSGKNKSYDVRIENFDVSF-----GDRVLLAGADVNLAWGRRYGLVGRNGLGKTT 218
+SR + K + + +E +VSF D +L G +++ G+ VG +G GK+T
Sbjct: 554 DSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKST 613
Query: 219 LLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQS---------VLESDSVREDLLRRER 269
+++L + L P +L + + L+S VL + S+ E++ +
Sbjct: 614 SVQLL--QRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDN 671
Query: 270 ELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFS 329
+ E EAA A I++ +E + P + + + G + S
Sbjct: 672 SRVVPLD----EIKEAANAANIHSFIEGL-----PEKYNTQVGLKG----------AQLS 712
Query: 330 GGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPS--TILVVSHDRNFL 387
GG + RLA+ARAL +P +LLLDE T+ LD + +++ L + T LVV+H L
Sbjct: 713 GGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHR---L 769
Query: 388 NAI--ATDIIHLHSQRL 402
+AI A I+ LH+ ++
Sbjct: 770 SAIQNADLIVVLHNGKI 786
Score = 43.1 bits (100), Expect = 9e-04
Identities = 27/65 (41%), Positives = 36/65 (55%), Gaps = 2/65 (3%)
Query: 609 ASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGG--VILVSHD 666
A +SGGQK R+A A+ + P ILDE T+ LD E+ A+ AL G I+V+H
Sbjct: 78 AQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHR 137
Query: 667 ERFIR 671
IR
Sbjct: 138 LSTIR 142
Score = 39.3 bits (90), Expect = 0.013
Identities = 22/58 (37%), Positives = 36/58 (62%), Gaps = 2/58 (3%)
Query: 327 EFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQ--TWPSTILVVSH 382
+ SGG + R+A+ARAL P +L+LDE T+ LD + ++ L+ + T +VV+H
Sbjct: 79 QMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVAH 136
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 56.6 bits (135), Expect = 8e-08
Identities = 65/215 (30%), Positives = 96/215 (44%), Gaps = 41/215 (19%)
Query: 184 DVSFG-----DRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLH 238
DVSF DR +L G L G LVG NG GK+T+ +L ++L P +L
Sbjct: 472 DVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALL--QNLYQPTGGQVLL 529
Query: 239 VEQEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEI 298
E+ ++ + L S + S V ++ + + IA G L+
Sbjct: 530 DEKPISQYEHCYLHSQVVS--VGQEPVLFSGSVRNNIAYG----------------LQSC 571
Query: 299 EADKAPARASVILAGLGFTPKMQQ-------QPTREFSGGWRMRLALARALFARPDLLLL 351
E DK A A A F +M+ + + + G + RLA+ARAL P +L+L
Sbjct: 572 EDDKVMAAAQAAHAD-DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLIL 630
Query: 352 DEPTNMLDVRAILWLENYLQTWPS----TILVVSH 382
DE T+ LDV+ E LQ W S T+LV++H
Sbjct: 631 DEATSALDVQC----EQALQDWNSRGDRTVLVIAH 661
Score = 44.3 bits (103), Expect = 4e-04
Identities = 54/238 (22%), Positives = 102/238 (42%), Gaps = 30/238 (12%)
Query: 491 ILQLDEVDFYYD--PKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLL---------- 538
+++ +V F Y P + L+ + +VG NG+GKST+ LL
Sbjct: 467 VVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ 526
Query: 539 -LGDLAPVRGIRHAHRNLKIGYFSQHHV-------EQLDLNVSAVE----LLARKFPGRP 586
L D P+ H + + ++ Q V + + + E + A +
Sbjct: 527 VLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHAD 586
Query: 587 EEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETI 646
+ + G Y GE + L+ GQK R+A A+ + P ILDE T+ LD++
Sbjct: 587 DFIQEMEHGIYTDVGEKG----SQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
Query: 647 EALGRALNNFRGGVILVSHDERFIRLVCRELWVCEG--GGVTRVEGGFDQYRALLQEQ 702
+AL + V++++H + ++ + L + EG + +++ G D Y L+Q++
Sbjct: 643 QALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQEGQDLYSRLVQQR 700
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 55.5 bits (132), Expect = 2e-07
Identities = 64/219 (29%), Positives = 95/219 (43%), Gaps = 43/219 (19%)
Query: 184 DVSFG-----DRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLH 238
DVSF D ++L G L G LVG NG GK+T+ +L ++L P LL
Sbjct: 567 DVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALL--QNLYQPTGGQLL- 623
Query: 239 VEQEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAA--------GRAEGSEAAELAE 290
+ G P + R L Q+AA GR+ A
Sbjct: 624 ----LDGKPLPQYE---------------HRYLHRQVAAVGQEPQVFGRSLQENIAYGLT 664
Query: 291 IYAKLEEIEADKAPARASVILAGL--GFTPKMQQQPTREFSGGWRMRLALARALFARPDL 348
+EEI A + A ++GL G+ ++ + + + SGG R +ALARAL +P +
Sbjct: 665 QKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGS-QLSGGQRQAVALARALIRKPCV 723
Query: 349 LLLDEPTNMLDVRAILWLENYLQTWP-----STILVVSH 382
L+LD+ T+ LD + L +E L P S +L+ H
Sbjct: 724 LILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQH 762
Score = 43.1 bits (100), Expect = 9e-04
Identities = 62/300 (20%), Positives = 112/300 (37%), Gaps = 58/300 (19%)
Query: 430 QQQYRQHIQVFIDRFRYNANRASQVQSKLKMLEKLPELKPVDKESEVVMKFPDGFEKFSP 489
Q Q+ Q ++V + + + + L++ P P + + ++
Sbjct: 511 QMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLE---------- 560
Query: 490 PILQLDEVDFYYD--PKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRG 547
++Q +V F Y P ++ L+ + +VG NG+GKST+ LL P G
Sbjct: 561 GLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGG 620
Query: 548 I-------------RHAHRNL----------------KIGYFSQHHVEQLDLNVSAVELL 578
R+ HR + I Y ++ +AV+
Sbjct: 621 QLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSG 680
Query: 579 ARKFPGRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPT 638
A F + Y ++ G + LSGGQ+ VA A+ + P ILD+ T
Sbjct: 681 AHSFISGLPQGYDTEVDEAG----------SQLSGGQRQAVALARALIRKPCVLILDDAT 730
Query: 639 NHLD----METIEALGRALNNFRGGVILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQ 694
+ LD ++ + L + + V+L++ + L++ EGG + EGG Q
Sbjct: 731 SALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFL-EGGAIR--EGGTHQ 787
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 55.5 bits (132), Expect = 2e-07
Identities = 83/314 (26%), Positives = 132/314 (42%), Gaps = 53/314 (16%)
Query: 203 GRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSVLESDSVRE 262
G +GL+G NG GKTT KML + +GD T A +S+L + S
Sbjct: 1965 GECFGLLGVNGAGKTTTFKMLTGDTT-------------VTSGDATVAGKSILTNISEVH 2011
Query: 263 DLLRRERELTA--QIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKM 320
+ + A ++ GR E +YA+L + A++ A+ + LG T
Sbjct: 2012 QNMGYCPQFDAIDELLTGR-------EHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYA 2064
Query: 321 QQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQT---WPSTI 377
+SGG + +L+ A AL P L+LLDEPT +D +A L N + + +
Sbjct: 2065 DCL-AGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAV 2123
Query: 378 LVVSHDRNFLNAIAT--------------DIIHLHSQRLDGYRGDFETFIKSKQERLLNQ 423
++ SH A+ T I HL S+ DGY + IKS ++ LL
Sbjct: 2124 VLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMK--IKSPKDDLLPD 2181
Query: 424 QREYEAQQQYRQHIQVFIDRFRYNANRASQVQSKLKMLEKLPELKPVDKESEVVMKFPDG 483
E Q ++ + + R R+ QV S L ++ +L K+S ++
Sbjct: 2182 LNPVE--QFFQGNFPGSVQRERHYNMLQFQVSS--SSLARIFQLLLSHKDSLLI------ 2231
Query: 484 FEKFSPPILQLDEV 497
E++S LD+V
Sbjct: 2232 -EEYSVTQTTLDQV 2244
Score = 50.1 bits (118), Expect = 7e-06
Identities = 60/215 (27%), Positives = 89/215 (41%), Gaps = 27/215 (12%)
Query: 491 ILQLDEVD-FYYDPKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRG-- 547
IL+L E+ Y RL V ++G NGAGK+T K+L GD G
Sbjct: 1937 ILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDA 1996
Query: 548 ----------IRHAHRNLKIGYFSQHH-VEQLDLNVSAVELLARKFPGRPEEEYRHQLGR 596
I H+N+ GY Q +++L + L AR G P EE ++
Sbjct: 1997 TVAGKSILTNISEVHQNM--GYCPQFDAIDELLTGREHLYLYAR-LRGVPAEEIE-KVAN 2052
Query: 597 YGISGELAMRPLA-----SLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGR 651
+ I L + A + SGG K +++ A + CP +LDEPT +D + L
Sbjct: 2053 WSIKS-LGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWN 2111
Query: 652 AL-NNFRGG--VILVSHDERFIRLVCRELWVCEGG 683
+ + R G V+L SH +C L + G
Sbjct: 2112 VIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKG 2146
Score = 46.2 bits (108), Expect = 1e-04
Identities = 46/175 (26%), Positives = 78/175 (44%), Gaps = 23/175 (13%)
Query: 510 RLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRGI-----RHAHRNL-----KIGY 559
RL+++ +G NGAGK+T L +L G L P G R +L +G
Sbjct: 948 RLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGM 1007
Query: 560 FSQHHVEQLDLNVSAVELLARKFPGRPEEEYRHQL-------GRYGISGELAMRPLASLS 612
QH++ L V+ L + G+ +EE + ++ G + E A LS
Sbjct: 1008 CPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQ----DLS 1063
Query: 613 GGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGG--VILVSH 665
GG + +++ A + ILDEPT+ +D + ++ L +R G +I+ +H
Sbjct: 1064 GGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTH 1118
Score = 37.7 bits (86), Expect = 0.037
Identities = 41/153 (26%), Positives = 67/153 (43%), Gaps = 23/153 (15%)
Query: 209 VGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSVLESDSVREDL--LR 266
+G NG GKTT L +L L P ++L V G D D+VR+ L
Sbjct: 962 LGHNGAGKTTTLSILT--GLLPPTSGTVL-----VGGRDIET-----SLDAVRQSLGMCP 1009
Query: 267 RERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTR 326
+ L + AE YA+L+ ++A +L G K ++ +
Sbjct: 1010 QHNILFHHLTV--------AEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEE-AQ 1060
Query: 327 EFSGGWRMRLALARALFARPDLLLLDEPTNMLD 359
+ SGG + +L++A A +++LDEPT+ +D
Sbjct: 1061 DLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVD 1093
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 54.7 bits (130), Expect = 3e-07
Identities = 66/235 (28%), Positives = 94/235 (40%), Gaps = 56/235 (23%)
Query: 473 ESEVVMKFPDGF---EKFSPPILQLDEVDFYYD--PKHVIFSRLSVSADLESRICVVGEN 527
E E + F +G EK L+ V F Y P+ IF S+S S +VG +
Sbjct: 470 EREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPS 529
Query: 528 GAGKSTMLKLLLGDLAPVRGI----RHAHRNL-------KIGYFSQHHV----------- 565
G+GKST+L LLL P G H R L KIG SQ +
Sbjct: 530 GSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIA 589
Query: 566 -----------EQLDLNVSAVELLA--RKFPGRPEEEYRHQLGRYGISGELAMRPLASLS 612
E++ +A R FP + + +G G+ LS
Sbjct: 590 YGADDPSSVTAEEIQRVAEVANAVAFIRNFP----QGFNTVVGEKGVL----------LS 635
Query: 613 GGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGG--VILVSH 665
GGQK R+A A+ + P +LDE T+ LD E + AL+ G V++++H
Sbjct: 636 GGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAH 690
Score = 45.4 bits (106), Expect = 2e-04
Identities = 53/182 (29%), Positives = 80/182 (43%), Gaps = 23/182 (12%)
Query: 208 LVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSVL---ESDSVREDL 264
LVG +G GK+T+L +L ISL G D L V + +V ++
Sbjct: 525 LVGPSGSGKSTVLSLLLRLYDPASGTISL-------DGHDIRQLNPVWLRSKIGTVSQEP 577
Query: 265 LRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIE--ADKAPARASVILAGLGFTPKMQQ 322
+ + IA G + S EEI+ A+ A A A + GF + +
Sbjct: 578 ILFSCSIAENIAYGADDPSSVTA--------EEIQRVAEVANAVAFIRNFPQGFNTVVGE 629
Query: 323 QPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPS--TILVV 380
+ SGG + R+A+ARAL P +LLLDE T+ LD ++ L T+LV+
Sbjct: 630 KGVL-LSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVI 688
Query: 381 SH 382
+H
Sbjct: 689 AH 690
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 53.1 bits (126), Expect = 9e-07
Identities = 54/205 (26%), Positives = 87/205 (42%), Gaps = 26/205 (12%)
Query: 203 GRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDD-TPALQSVLESDSVR 261
G +GL+G NG GKT+ KML GD+ T ++ + SV
Sbjct: 2081 GECFGLLGVNGAGKTSTFKMLT--------------------GDESTTGGEAFVNGHSVL 2120
Query: 262 EDLLRRERELT-AQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKM 320
++LL+ ++ L + A E ++Y +L I L L T K
Sbjct: 2121 KELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELT-KY 2179
Query: 321 QQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPST---I 377
+P +SGG + +L+ A AL P + LDEPT +D +A +L N + T +
Sbjct: 2180 ADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSV 2239
Query: 378 LVVSHDRNFLNAIATDIIHLHSQRL 402
++ SH A+ T + + + RL
Sbjct: 2240 VLTSHSMEECEALCTRLAIMVNGRL 2264
Score = 49.3 bits (116), Expect = 1e-05
Identities = 46/181 (25%), Positives = 81/181 (44%), Gaps = 15/181 (8%)
Query: 500 YYDPKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRG--------IRHA 551
Y D K + ++LS++ + +G NGAGK+T + +L G P G IR
Sbjct: 1000 YKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTE 1059
Query: 552 HRNLK--IGYFSQHHVEQLDLNVSAVELLARKFPGRPEEEYRHQLGRYGISGELAMRP-- 607
++ +G QH+V L V + +EE R ++ + EL+ +
Sbjct: 1060 MDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHS 1119
Query: 608 -LASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGG--VILVS 664
+ +LSGG K +++ A + ILDEPT +D A+ + ++ G ++L +
Sbjct: 1120 LVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLST 1179
Query: 665 H 665
H
Sbjct: 1180 H 1180
Score = 40.4 bits (93), Expect = 0.006
Identities = 46/178 (25%), Positives = 76/178 (42%), Gaps = 18/178 (10%)
Query: 523 VVGENGAGKSTMLKLLLGDLAPVRG--IRHAHRNLK--------IGYFSQHHVEQLDLNV 572
++G NGAGK++ K+L GD + G + H LK +GY Q +L
Sbjct: 2086 LLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTA 2145
Query: 573 SAVELLARKFPGRPEEE----YRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPC 628
L + G ++ + L + ++ + A +P + SGG K +++ A +
Sbjct: 2146 REHLQLYTRLRGISWKDEARVVKWALEKLELT-KYADKPAGTYSGGNKRKLSTAIALIGY 2204
Query: 629 PNFYILDEPTNHLDMETIEAL-GRALNNFRGG--VILVSHDERFIRLVCRELWVCEGG 683
P F LDEPT +D + L L+ + G V+L SH +C L + G
Sbjct: 2205 PAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNG 2262
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 53.1 bits (126), Expect = 9e-07
Identities = 54/205 (26%), Positives = 87/205 (42%), Gaps = 26/205 (12%)
Query: 203 GRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDD-TPALQSVLESDSVR 261
G +GL+G NG GKT+ KML GD+ T ++ + SV
Sbjct: 2111 GECFGLLGVNGAGKTSTFKMLT--------------------GDESTTGGEAFVNGHSVL 2150
Query: 262 EDLLRRERELT-AQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKM 320
++LL+ ++ L + A E ++Y +L I L L T K
Sbjct: 2151 KELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELT-KY 2209
Query: 321 QQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPST---I 377
+P +SGG + +L+ A AL P + LDEPT +D +A +L N + T +
Sbjct: 2210 ADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSV 2269
Query: 378 LVVSHDRNFLNAIATDIIHLHSQRL 402
++ SH A+ T + + + RL
Sbjct: 2270 VLTSHSMEECEALCTRLAIMVNGRL 2294
Score = 49.3 bits (116), Expect = 1e-05
Identities = 46/181 (25%), Positives = 81/181 (44%), Gaps = 15/181 (8%)
Query: 500 YYDPKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRG--------IRHA 551
Y D K + ++LS++ + +G NGAGK+T + +L G P G IR
Sbjct: 1030 YKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTE 1089
Query: 552 HRNLK--IGYFSQHHVEQLDLNVSAVELLARKFPGRPEEEYRHQLGRYGISGELAMRP-- 607
++ +G QH+V L V + +EE R ++ + EL+ +
Sbjct: 1090 MDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHS 1149
Query: 608 -LASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGG--VILVS 664
+ +LSGG K +++ A + ILDEPT +D A+ + ++ G ++L +
Sbjct: 1150 LVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLST 1209
Query: 665 H 665
H
Sbjct: 1210 H 1210
Score = 40.4 bits (93), Expect = 0.006
Identities = 46/178 (25%), Positives = 76/178 (42%), Gaps = 18/178 (10%)
Query: 523 VVGENGAGKSTMLKLLLGDLAPVRG--IRHAHRNLK--------IGYFSQHHVEQLDLNV 572
++G NGAGK++ K+L GD + G + H LK +GY Q +L
Sbjct: 2116 LLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTA 2175
Query: 573 SAVELLARKFPGRPEEE----YRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPC 628
L + G ++ + L + ++ + A +P + SGG K +++ A +
Sbjct: 2176 REHLQLYTRLRGISWKDEARVVKWALEKLELT-KYADKPAGTYSGGNKRKLSTAIALIGY 2234
Query: 629 PNFYILDEPTNHLDMETIEAL-GRALNNFRGG--VILVSHDERFIRLVCRELWVCEGG 683
P F LDEPT +D + L L+ + G V+L SH +C L + G
Sbjct: 2235 PAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNG 2292
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 53.1 bits (126), Expect = 9e-07
Identities = 53/182 (29%), Positives = 79/182 (43%), Gaps = 24/182 (13%)
Query: 495 DEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRG-IRHAHR 553
D V F Y + S +S ++ +VG +G+GKST+++LL P +G I A +
Sbjct: 476 DNVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQ 535
Query: 554 NLK----------IGYFSQHHVEQLDLNVSAVELLARKFPGRPEEEYR-------HQL-- 594
N++ +G Q V L N LL PEE Y H
Sbjct: 536 NIQDVSLESLRRAVGVVPQDAV--LFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAIL 593
Query: 595 -GRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRAL 653
+G ++ R L LSGG+K RVA A+ + P + DE T+ LD T E + A+
Sbjct: 594 RMPHGYDTQVGERGL-KLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAM 652
Query: 654 NN 655
+
Sbjct: 653 KD 654
Score = 42.4 bits (98), Expect = 0.002
Identities = 42/178 (23%), Positives = 82/178 (46%), Gaps = 15/178 (8%)
Query: 182 NFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQ 241
+F+ G +VL +G + G++ +VG +G GK+T++++L P S+ Q
Sbjct: 479 HFEYIEGQKVL-SGISFEVPAGKKVAIVGGSGSGKSTIVRLLFR--FYEPQKGSIYLAGQ 535
Query: 242 EVAGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEAD 301
+ +L+ + V +D + + + G S E+YA A
Sbjct: 536 NIQDVSLESLRRAV--GVVPQDAVLFHNTIYYNLLYGNISASPE----EVYAV-----AK 584
Query: 302 KAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLD 359
A +++ G+ ++ ++ + SGG + R+A+ARA+ P ++L DE T+ LD
Sbjct: 585 LAGLHDAILRMPHGYDTQVGERGLK-LSGGEKQRVAIARAILKDPPVILYDEATSSLD 641
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 52.0 bits (123), Expect = 2e-06
Identities = 55/179 (30%), Positives = 79/179 (44%), Gaps = 20/179 (11%)
Query: 523 VVGENGAGKSTMLKLLLGDLAPVRG--IRHAHR--------NLKIGYFSQHH-VEQLDLN 571
++G NGAGK++ +++ GD RG + H +L +GY Q + +L
Sbjct: 1825 LLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTG 1884
Query: 572 VSAVELLARKFPGRPEEEYRHQLG----RYGISGELAMRPLASLSGGQKSRVAFAQMTMP 627
+ELLAR G PE + G R G+S A RP + SGG K ++A A +
Sbjct: 1885 REHLELLAR-LRGVPEAQVAQTAGSGLARLGLSW-YADRPAGTYSGGNKRKLATALALVG 1942
Query: 628 CPNFYILDEPTNHLDMETIEALGRA-LNNFRGG--VILVSHDERFIRLVCRELWVCEGG 683
P LDEPT +D L + L R G V+L SH +C L + G
Sbjct: 1943 DPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNG 2001
Score = 50.8 bits (120), Expect = 4e-06
Identities = 53/188 (28%), Positives = 81/188 (43%), Gaps = 31/188 (16%)
Query: 203 GRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSV---LESDS 259
G +GL+G NG GKT+ +M+ +L L VA + + A S+ +SD+
Sbjct: 1820 GECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVL--AGHSVAREPSAAHLSMGYCPQSDA 1877
Query: 260 VREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPK 319
+ E L RE E+ A+L + + A LA LG +
Sbjct: 1878 IFELLTGREH-------------------LELLARLRGVPEAQVAQTAGSGLARLGLS-W 1917
Query: 320 MQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPSTILV 379
+P +SGG + +LA A AL P ++ LDEPT +D A +L W S + V
Sbjct: 1918 YADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFL------WNSLLAV 1971
Query: 380 VSHDRNFL 387
V R+ +
Sbjct: 1972 VREGRSVM 1979
Score = 38.1 bits (87), Expect = 0.028
Identities = 47/170 (27%), Positives = 72/170 (42%), Gaps = 25/170 (14%)
Query: 193 LAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDT---P 249
L G ++ G +G NG GKTT L +L+ L P+ S + +V P
Sbjct: 824 LRGLSLDFYQGHITAFLGHNGAGKTTTLSILS--GLFPPSGGSAFILGHDVRSSMAAIRP 881
Query: 250 ALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASV 309
L V +V D+L + + GR +G AA + E D+
Sbjct: 882 HL-GVCPQYNVLFDMLTVDEHVWFY---GRLKGLSAAVVGP--------EQDR------- 922
Query: 310 ILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLD 359
+L +G K Q TR SGG + +L++A A +++LDEPT +D
Sbjct: 923 LLQDVGLVSKQSVQ-TRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVD 971
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 51.6 bits (122), Expect = 2e-06
Identities = 49/181 (27%), Positives = 84/181 (46%), Gaps = 26/181 (14%)
Query: 189 DRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKML-------ATRSLRVPAHISLLHVEQ 241
D +L G + + G+ LVG +G GK+T++++L A + L I L+V+
Sbjct: 1049 DIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQW 1108
Query: 242 EVAGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEAD 301
A + + +L S+ E++ + + E AA+ A I+A +E +
Sbjct: 1109 LRAHLGIVSQEPILFDCSIAENIAYGDNSRVVS----QEEIVRAAKEANIHAFIESL--- 1161
Query: 302 KAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVR 361
P + S + G + SGG + R+A+ARAL +P +LLLDE T+ LD
Sbjct: 1162 --PNKYSTKVGDKG----------TQLSGGQKQRIAIARALVRQPHILLLDEATSALDTE 1209
Query: 362 A 362
+
Sbjct: 1210 S 1210
Score = 48.1 bits (113), Expect = 3e-05
Identities = 46/175 (26%), Positives = 80/175 (45%), Gaps = 22/175 (12%)
Query: 192 LLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPAL 251
+L G ++ + G+ LVG +G GK+T ++++ + L P + Q++ + L
Sbjct: 409 ILKGLNLKVQSGQTVALVGNSGCGKSTTVQLM--QRLYDPTEGMVSVDGQDIRTINVRFL 466
Query: 252 QSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEAD----KAPARA 307
+ ++ S +E +L IA G E + EI ++E A K P +
Sbjct: 467 REIIGVVS-QEPVL-----FATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKF 520
Query: 308 SVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRA 362
++ G + SGG + R+A+ARAL P +LLLDE T+ LD +
Sbjct: 521 DTLVGERG----------AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 565
Score = 47.0 bits (110), Expect = 6e-05
Identities = 52/194 (26%), Positives = 82/194 (42%), Gaps = 24/194 (12%)
Query: 496 EVDFYYD--PKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRGI----R 549
EV F Y P + LS+ + +VG +G GKST+++LL P+ G
Sbjct: 1039 EVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDG 1098
Query: 550 HAHRNLKIGYFSQH----HVEQLDLNVSAVELLARKFPGR--PEEEYRHQLGRYGISGEL 603
+ L + + H E + + S E +A R +EE I +
Sbjct: 1099 KEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFI 1158
Query: 604 AMRPL----------ASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRAL 653
P LSGGQK R+A A+ + P+ +LDE T+ LD E+ + + AL
Sbjct: 1159 ESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEAL 1218
Query: 654 NNFRGG--VILVSH 665
+ R G I+++H
Sbjct: 1219 DKAREGRTCIVIAH 1232
Score = 44.3 bits (103), Expect = 4e-04
Identities = 47/206 (22%), Positives = 82/206 (39%), Gaps = 42/206 (20%)
Query: 492 LQLDEVDFYYDPKHV--IFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRGIR 549
L+ V F Y + I L++ + +VG +G GKST ++L+ P G+
Sbjct: 392 LEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMV 451
Query: 550 HAH----RNLKIGY------------------------FSQHHVEQLDLNVSAVELLARK 581
R + + + + + +V ++ + E A
Sbjct: 452 SVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYD 511
Query: 582 FPGRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHL 641
F + ++ +G G A LSGGQK R+A A+ + P +LDE T+ L
Sbjct: 512 FIMKLPHKFDTLVGERG----------AQLSGGQKQRIAIARALVRNPKILLLDEATSAL 561
Query: 642 DMETIEALGRALNNFRGG--VILVSH 665
D E+ + AL+ R G I+++H
Sbjct: 562 DTESEAVVQVALDKARKGRTTIVIAH 587
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 51.2 bits (121), Expect = 3e-06
Identities = 62/220 (28%), Positives = 89/220 (40%), Gaps = 37/220 (16%)
Query: 491 ILQLDEVDFYYDPKHV-IFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRG-- 547
IL++ E+ Y K R+ V ++G NGAGKS+ K+L GD RG
Sbjct: 1911 ILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDA 1970
Query: 548 ----------IRHAHRNLKIGYFSQHH-VEQLDLNVSAVELLARKFPGRPEEEYRHQLGR 596
I H+N+ GY Q + +L VE A G PE+E
Sbjct: 1971 FLNKNSILSNIHEVHQNM--GYCPQFDAITELLTGREHVEFFA-LLRGVPEKE------- 2020
Query: 597 YGISGELAMRPL----------ASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETI 646
G GE A+R L + SGG K +++ A + P LDEPT +D +
Sbjct: 2021 VGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKAR 2080
Query: 647 EALGR-ALNNFRGG--VILVSHDERFIRLVCRELWVCEGG 683
L AL+ + G V+L SH +C + + G
Sbjct: 2081 RFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNG 2120
Score = 43.5 bits (101), Expect = 7e-04
Identities = 53/208 (25%), Positives = 85/208 (40%), Gaps = 18/208 (8%)
Query: 474 SEVVMKFPDGFEKFSPPILQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAGKST 533
SE+ M+ K I L +V Y D V L+++ +G NGAGK+T
Sbjct: 884 SEICMEEEPTHLKLGVSIQNLVKV--YRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTT 941
Query: 534 MLKLLLGDLAPVRG--------IRHAHRNLK--IGYFSQHHVEQLDLNVSAVELLARKFP 583
+ +L G P G IR ++ +G QH+V L V +
Sbjct: 942 TMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLK 1001
Query: 584 GRPEEEYRHQLGRYGISGELAMRPLAS----LSGGQKSRVAFAQMTMPCPNFYILDEPTN 639
G E+ + ++ + + L L S LSGG + +++ A + ILDEPT
Sbjct: 1002 GLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTA 1061
Query: 640 HLDMETIEALGRALNNFRGG--VILVSH 665
+D + + L +R G +IL +H
Sbjct: 1062 GVDPYSRRGIWELLLKYRQGRTIILSTH 1089
Score = 43.1 bits (100), Expect = 9e-04
Identities = 48/216 (22%), Positives = 86/216 (39%), Gaps = 28/216 (12%)
Query: 152 EEASASQAGSRK----ESRLESSGKNKSYDVRIENFDVSFGD--RVLLAGADVNLAWGRR 205
E S GS + E +E + V I+N + D +V + G +N G+
Sbjct: 869 ESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQI 928
Query: 206 YGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQS--VLESDSVRED 263
+G NG GKTT + +L L P + + +++ + + Q+ V +V D
Sbjct: 929 TSFLGHNGAGKTTTMSILT--GLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFD 986
Query: 264 LLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQ 323
+L E + YA+L+ + A + +G +
Sbjct: 987 MLTVEEHIW------------------FYARLKGLSEKHVKAEMEQMALDVGLPSSKLKS 1028
Query: 324 PTREFSGGWRMRLALARALFARPDLLLLDEPTNMLD 359
T + SGG + +L++A A +++LDEPT +D
Sbjct: 1029 KTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVD 1064
Score = 41.6 bits (96), Expect = 0.003
Identities = 50/193 (25%), Positives = 79/193 (40%), Gaps = 35/193 (18%)
Query: 198 VNLAWGRRYGLVGRNGLGKTTLLKMLA--TRSLRVPAHI---SLLHVEQEVAGDDTPALQ 252
V + G +GL+G NG GK++ KML T R A + S+L EV + +
Sbjct: 1934 VGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQN----MG 1989
Query: 253 SVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILA 312
+ D++ E L RE E +A L + + +
Sbjct: 1990 YCPQFDAITELLTGREH-------------------VEFFALLRGVPEKEVGKVGEWAIR 2030
Query: 313 GLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQT 372
LG K ++ +SGG + +L+ A AL P ++ LDEPT +D +A +L
Sbjct: 2031 KLGLV-KYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFL------ 2083
Query: 373 WPSTILVVSHDRN 385
W + VV R+
Sbjct: 2084 WNCALSVVKEGRS 2096
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 51.2 bits (121), Expect = 3e-06
Identities = 42/137 (30%), Positives = 65/137 (47%), Gaps = 22/137 (16%)
Query: 521 ICVVGENGAGKSTMLKLLLGDLAPVRGIRHAHRNLKIGYFSQH---HVEQLDLNVSAVEL 577
+ VVG GAGKS++L +LG+LAP G+ H +I Y SQ L N+ L
Sbjct: 441 LAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG--RIAYVSQQPWVFSGTLRSNI----L 494
Query: 578 LARKFPGRPEEEYRHQLGRYGISGELAMRP----------LASLSGGQKSRVAFAQMTMP 627
+K+ +E Y + + +L + +LSGGQK+RV A+
Sbjct: 495 FGKKY---EKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQ 551
Query: 628 CPNFYILDEPTNHLDME 644
+ Y+LD+P + +D E
Sbjct: 552 DADIYLLDDPLSAVDAE 568
Score = 37.0 bits (84), Expect = 0.063
Identities = 63/265 (23%), Positives = 114/265 (43%), Gaps = 47/265 (17%)
Query: 161 SRKESRLESSGKNKSYDVRIENFDVSFGDRV----LLAGADVNLAWGRRYGLVGRNGLGK 216
S++ +L S GK V +++F +F D+ L G + G +VG G GK
Sbjct: 396 SQRNRQLPSDGKKM---VHVQDF-TAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
Query: 217 TTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSVLESDSVREDLL---RRERELTA 273
++LL A P+H L+ V +A + Q + S ++R ++L + E+E
Sbjct: 452 SSLLS--AVLGELAPSH-GLVSVHGRIA---YVSQQPWVFSGTLRSNILFGKKYEKERYE 505
Query: 274 QIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFSGGWR 333
++ +A L + LE+ + R + + SGG +
Sbjct: 506 KVI-------KACALKKDLQLLEDGDLTVIGDRGTTL------------------SGGQK 540
Query: 334 MRLALARALFARPDLLLLDEPTNMLDV---RAILWLENYLQTWPSTILVVSHDRNFLNAI 390
R+ LARA++ D+ LLD+P + +D R + L ++V+H +L A
Sbjct: 541 ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKA- 599
Query: 391 ATDIIHLHSQRLDGYRGDFETFIKS 415
A+ I+ L ++ +G + F+KS
Sbjct: 600 ASQILILKDGKM-VQKGTYTEFLKS 623
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 51.2 bits (121), Expect = 3e-06
Identities = 42/137 (30%), Positives = 65/137 (47%), Gaps = 22/137 (16%)
Query: 521 ICVVGENGAGKSTMLKLLLGDLAPVRGIRHAHRNLKIGYFSQH---HVEQLDLNVSAVEL 577
+ VVG GAGKS++L +LG+LAP G+ H +I Y SQ L N+ L
Sbjct: 441 LAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG--RIAYVSQQPWVFSGTLRSNI----L 494
Query: 578 LARKFPGRPEEEYRHQLGRYGISGELAMRP----------LASLSGGQKSRVAFAQMTMP 627
+K+ +E Y + + +L + +LSGGQK+RV A+
Sbjct: 495 FGKKY---EKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQ 551
Query: 628 CPNFYILDEPTNHLDME 644
+ Y+LD+P + +D E
Sbjct: 552 DADIYLLDDPLSAVDAE 568
Score = 41.2 bits (95), Expect = 0.003
Identities = 54/249 (21%), Positives = 103/249 (41%), Gaps = 61/249 (24%)
Query: 444 FRYNANRASQVQSKLKMLEKLPELKPVDKESEVVMKFPDGFEKFSPP------ILQLDEV 497
F++ ++++V++ + +E++ E ++KE+ P ++K PP ++ D V
Sbjct: 993 FQWCVRQSAEVENMMISVERVIEYTDLEKEA------PWEYQKRPPPAWPHEGVIIFDNV 1046
Query: 498 DFYYDPKH-VIFSRLSVSADLESRICVVGENGAGKSTMLKLL------------------ 538
+F Y P ++ L+ + ++ +VG GAGKS+++ L
Sbjct: 1047 NFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTT 1106
Query: 539 ---LGDL---------APVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVEL--LARKFPG 584
L DL PV +NL F++H E+L + V+L PG
Sbjct: 1107 EIGLHDLRKKMSIIPQEPVLFTGTMRKNL--DPFNEHTDEELWNALQEVQLKETIEDLPG 1164
Query: 585 RPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDME 644
+ + E L G ++ S GQ+ V A+ + I+DE T ++D
Sbjct: 1165 KMDTE----LAESG----------SNFSVGQRQLVCLARAILRKNQILIIDEATANVDPR 1210
Query: 645 TIEALGRAL 653
T E + + +
Sbjct: 1211 TDELIQKKI 1219
Score = 37.7 bits (86), Expect = 0.037
Identities = 60/272 (22%), Positives = 110/272 (40%), Gaps = 33/272 (12%)
Query: 182 NFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQ 241
NF S G ++L + + G+VGR G GK++L+ L L E
Sbjct: 1047 NFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISAL----------FRLSEPEG 1096
Query: 242 EVAGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEAD 301
++ D + L + ++ +E L + E++ L+E++
Sbjct: 1097 KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLK 1156
Query: 302 KA----PARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNM 357
+ P + LA G FS G R + LARA+ + +L++DE T
Sbjct: 1157 ETIEDLPGKMDTELAESG----------SNFSVGQRQLVCLARAILRKNQILIIDEATAN 1206
Query: 358 LDVRAILWLENYLQT--WPSTILVVSHDRNFLNAIATD-IIHLHSQRLDGYRGDFETFIK 414
+D R ++ ++ T+L ++H N + I +D I+ L S RL Y + ++
Sbjct: 1207 VDPRTDELIQKKIREKFAHCTVLTIAHRLNTI--IDSDKIMVLDSGRLKEYDEPY-VLLQ 1263
Query: 415 SKQE---RLLNQQREYEAQQQYRQHIQVFIDR 443
+K+ +++ Q + EA QV+ R
Sbjct: 1264 NKESLFYKMVQQLGKAEAAALTETAKQVYFKR 1295
Score = 37.0 bits (84), Expect = 0.063
Identities = 63/265 (23%), Positives = 114/265 (43%), Gaps = 47/265 (17%)
Query: 161 SRKESRLESSGKNKSYDVRIENFDVSFGDRV----LLAGADVNLAWGRRYGLVGRNGLGK 216
S++ +L S GK V +++F +F D+ L G + G +VG G GK
Sbjct: 396 SQRNRQLPSDGKKM---VHVQDF-TAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
Query: 217 TTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSVLESDSVREDLL---RRERELTA 273
++LL A P+H L+ V +A + Q + S ++R ++L + E+E
Sbjct: 452 SSLLS--AVLGELAPSH-GLVSVHGRIA---YVSQQPWVFSGTLRSNILFGKKYEKERYE 505
Query: 274 QIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFSGGWR 333
++ +A L + LE+ + R + + SGG +
Sbjct: 506 KVI-------KACALKKDLQLLEDGDLTVIGDRGTTL------------------SGGQK 540
Query: 334 MRLALARALFARPDLLLLDEPTNMLDV---RAILWLENYLQTWPSTILVVSHDRNFLNAI 390
R+ LARA++ D+ LLD+P + +D R + L ++V+H +L A
Sbjct: 541 ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKA- 599
Query: 391 ATDIIHLHSQRLDGYRGDFETFIKS 415
A+ I+ L ++ +G + F+KS
Sbjct: 600 ASQILILKDGKM-VQKGTYTEFLKS 623
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 50.4 bits (119), Expect = 6e-06
Identities = 55/244 (22%), Positives = 102/244 (41%), Gaps = 53/244 (21%)
Query: 167 LESSGKNKSYDVRIENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATR 226
++ G S VR F + D L G ++ G +VG+ G GK++LL L
Sbjct: 635 VKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 694
Query: 227 SLRVPAHI----SLLHVEQEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEG 282
+V H+ S+ +V Q Q+ +++DS+RE++L
Sbjct: 695 MDKVEGHVAIKGSVAYVPQ----------QAWIQNDSLRENIL----------------- 727
Query: 283 SEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTRE----FSGGWRMRLAL 338
+L E Y ++ +A +L L P + E SGG + R++L
Sbjct: 728 -FGCQLEEPYY--------RSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSL 778
Query: 339 ARALFARPDLLLLDEPTNMLDVRA-------ILWLENYLQTWPSTILVVSHDRNFLNAIA 391
ARA+++ D+ L D+P + +D ++ + L+ T ++V+H ++L +
Sbjct: 779 ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKN--KTRILVTHSMSYLPQVD 836
Query: 392 TDII 395
I+
Sbjct: 837 VIIV 840
Score = 42.4 bits (98), Expect = 0.002
Identities = 51/197 (25%), Positives = 78/197 (39%), Gaps = 33/197 (16%)
Query: 521 ICVVGENGAGKSTMLKLLLGDLAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLAR 580
+ VVG+ G GKS++L LL ++ V G H + Y Q Q D L
Sbjct: 674 VAVVGQVGCGKSSLLSALLAEMDKVEG--HVAIKGSVAYVPQQAWIQND------SLREN 725
Query: 581 KFPGRPEEE--YRHQLGRYGISGELAMRPLA----------SLSGGQKSRVAFAQMTMPC 628
G EE YR + + +L + P +LSGGQK RV+ A+
Sbjct: 726 ILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSN 785
Query: 629 PNFYILDEPTN--------HLDMETIEALGRALNNFRGGVILVSHDERFIRLVCRELWVC 680
+ Y+ D+P + H+ I G N R ILV+H ++ V ++ +
Sbjct: 786 ADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTR---ILVTHSMSYLPQV--DVIIV 840
Query: 681 EGGGVTRVEGGFDQYRA 697
GG G + + A
Sbjct: 841 MSGGKISEMGSYQELLA 857
Score = 31.2 bits (69), Expect = 3.5
Identities = 21/92 (22%), Positives = 47/92 (51%), Gaps = 14/92 (15%)
Query: 451 ASQVQSKLKMLEKLPELKPVDKESEVVMKFPDGFEKFSPPIL--QLDEVDF------YYD 502
+S++++ + +E+L E +KE+ P ++ +PP Q+ V+F Y +
Sbjct: 1251 SSEMETNIVAVERLKEYSETEKEA------PWQIQETAPPSSWPQVGRVEFRNYCLRYRE 1304
Query: 503 PKHVIFSRLSVSADLESRICVVGENGAGKSTM 534
+ ++V+ + ++ +VG GAGKS++
Sbjct: 1305 DLDFVLRHINVTINGGEKVGIVGRTGAGKSSL 1336
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 50.4 bits (119), Expect = 6e-06
Identities = 55/244 (22%), Positives = 102/244 (41%), Gaps = 53/244 (21%)
Query: 167 LESSGKNKSYDVRIENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATR 226
++ G S VR F + D L G ++ G +VG+ G GK++LL L
Sbjct: 635 VKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 694
Query: 227 SLRVPAHI----SLLHVEQEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEG 282
+V H+ S+ +V Q Q+ +++DS+RE++L
Sbjct: 695 MDKVEGHVAIKGSVAYVPQ----------QAWIQNDSLRENIL----------------- 727
Query: 283 SEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTRE----FSGGWRMRLAL 338
+L E Y ++ +A +L L P + E SGG + R++L
Sbjct: 728 -FGCQLEEPYY--------RSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSL 778
Query: 339 ARALFARPDLLLLDEPTNMLDVRA-------ILWLENYLQTWPSTILVVSHDRNFLNAIA 391
ARA+++ D+ L D+P + +D ++ + L+ T ++V+H ++L +
Sbjct: 779 ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKN--KTRILVTHSMSYLPQVD 836
Query: 392 TDII 395
I+
Sbjct: 837 VIIV 840
Score = 42.4 bits (98), Expect = 0.002
Identities = 51/197 (25%), Positives = 78/197 (39%), Gaps = 33/197 (16%)
Query: 521 ICVVGENGAGKSTMLKLLLGDLAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLAR 580
+ VVG+ G GKS++L LL ++ V G H + Y Q Q D L
Sbjct: 674 VAVVGQVGCGKSSLLSALLAEMDKVEG--HVAIKGSVAYVPQQAWIQND------SLREN 725
Query: 581 KFPGRPEEE--YRHQLGRYGISGELAMRPLA----------SLSGGQKSRVAFAQMTMPC 628
G EE YR + + +L + P +LSGGQK RV+ A+
Sbjct: 726 ILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSN 785
Query: 629 PNFYILDEPTN--------HLDMETIEALGRALNNFRGGVILVSHDERFIRLVCRELWVC 680
+ Y+ D+P + H+ I G N R ILV+H ++ V ++ +
Sbjct: 786 ADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTR---ILVTHSMSYLPQV--DVIIV 840
Query: 681 EGGGVTRVEGGFDQYRA 697
GG G + + A
Sbjct: 841 MSGGKISEMGSYQELLA 857
Score = 33.9 bits (76), Expect = 0.53
Identities = 48/234 (20%), Positives = 94/234 (40%), Gaps = 59/234 (25%)
Query: 451 ASQVQSKLKMLEKLPELKPVDKESEVVMKFPDGFEKFSPPIL--QLDEVDF------YYD 502
+S++++ + +E+L E +KE+ P ++ +PP Q+ V+F Y +
Sbjct: 1251 SSEMETNIVAVERLKEYSETEKEA------PWQIQETAPPSSWPQVGRVEFRNYCLRYRE 1304
Query: 503 PKHVIFSRLSVSADLESRICVVGENGAGKSTM----------------------LKLLLG 540
+ ++V+ + ++ +VG GAGKS++ K+ L
Sbjct: 1305 DLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLH 1364
Query: 541 DLA---------PVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPGRPEEEYR 591
DL PV + + + FSQ+ E++ ++ L + F ++
Sbjct: 1365 DLRFKITIIPQDPV--LFSGSLRMNLDPFSQYSDEEVWTSLELAHL--KDFVSALPDKLD 1420
Query: 592 HQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMET 645
H+ G +LS GQ+ V A+ + +LDE T +D+ET
Sbjct: 1421 HECAEGG----------ENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET 1464
Score = 32.0 bits (71), Expect = 2.0
Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Query: 329 SGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQTW--PSTILVVSHDRN 385
S G R + LARAL + +L+LDE T +D+ +++ ++T T+L ++H N
Sbjct: 1431 SVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLN 1489
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 50.1 bits (118), Expect = 7e-06
Identities = 53/200 (26%), Positives = 92/200 (46%), Gaps = 23/200 (11%)
Query: 504 KHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRG---IRH---------A 551
K + + +S+ ++G NGAGK+T+ K+L GD+ P G IR+ +
Sbjct: 1951 KIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDS 2010
Query: 552 HRNLKIGYFSQHHVEQLDLNVSAVELL--ARKFPGRPEEEYR---HQLGRYGISGELAMR 606
H +L +GY Q + LD V+ E L + G PE++ + H+L R R
Sbjct: 2011 HSSL-VGYCPQE--DALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDR 2067
Query: 607 PLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALN---NFRGGVILV 663
+ S G K +++ A + P+ +LDEP++ +D ++ L + ++ + VIL
Sbjct: 2068 ATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILT 2127
Query: 664 SHDERFIRLVCRELWVCEGG 683
SH +C L + G
Sbjct: 2128 SHSMEECEALCTRLAIMVNG 2147
Score = 49.3 bits (116), Expect = 1e-05
Identities = 51/200 (25%), Positives = 84/200 (42%), Gaps = 25/200 (12%)
Query: 198 VNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDT-PALQSVLE 256
+ + G +GL+G NG GKTT+ KML + +I + + + D+ +L
Sbjct: 1960 IGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCP 2019
Query: 257 SDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGF 316
+ +DL+ E L YA++ I +L L
Sbjct: 2020 QEDALDDLVTVEEHLY------------------FYARVHGIPEKDIKETVHKLLRRLHL 2061
Query: 317 TPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRA--ILW--LENYLQT 372
P + + T S G + +L+ A AL +P +LLLDEP++ +D ++ LW + +Q
Sbjct: 2062 MP-FKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN 2120
Query: 373 WPSTILVVSHDRNFLNAIAT 392
S IL SH A+ T
Sbjct: 2121 KCSVIL-TSHSMEECEALCT 2139
Score = 34.3 bits (77), Expect = 0.41
Identities = 18/59 (30%), Positives = 29/59 (49%)
Query: 165 SRLESSGKNKSYDVRIENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKML 223
S +E K+ + V + +G +V + ++N G L+G NG GKTT + ML
Sbjct: 1015 SNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISML 1073
Score = 30.8 bits (68), Expect = 4.5
Identities = 36/136 (26%), Positives = 59/136 (43%), Gaps = 17/136 (12%)
Query: 523 VVGENGAGKSTMLKLLLGDLAPVRGIRHAH-RNLK---------IGYFSQHHVEQLDLNV 572
++G NGAGK+T + +L G G + +++K +G QH V L
Sbjct: 1058 LLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTT 1117
Query: 573 SAVELL--ARKFP----GRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTM 626
LL + K P + EE + L G+ R + +LSGG K +++ + +
Sbjct: 1118 KEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKR-VGTLSGGMKRKLSISIALI 1176
Query: 627 PCPNFYILDEPTNHLD 642
ILDEP+ +D
Sbjct: 1177 GGSRVVILDEPSTGVD 1192
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 50.1 bits (118), Expect = 7e-06
Identities = 53/200 (26%), Positives = 92/200 (46%), Gaps = 23/200 (11%)
Query: 504 KHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRG---IRH---------A 551
K + + +S+ ++G NGAGK+T+ K+L GD+ P G IR+ +
Sbjct: 2269 KIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDS 2328
Query: 552 HRNLKIGYFSQHHVEQLDLNVSAVELL--ARKFPGRPEEEYR---HQLGRYGISGELAMR 606
H +L +GY Q + LD V+ E L + G PE++ + H+L R R
Sbjct: 2329 HSSL-VGYCPQE--DALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDR 2385
Query: 607 PLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALN---NFRGGVILV 663
+ S G K +++ A + P+ +LDEP++ +D ++ L + ++ + VIL
Sbjct: 2386 ATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILT 2445
Query: 664 SHDERFIRLVCRELWVCEGG 683
SH +C L + G
Sbjct: 2446 SHSMEECEALCTRLAIMVNG 2465
Score = 49.3 bits (116), Expect = 1e-05
Identities = 51/200 (25%), Positives = 84/200 (42%), Gaps = 25/200 (12%)
Query: 198 VNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDT-PALQSVLE 256
+ + G +GL+G NG GKTT+ KML + +I + + + D+ +L
Sbjct: 2278 IGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCP 2337
Query: 257 SDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGF 316
+ +DL+ E L YA++ I +L L
Sbjct: 2338 QEDALDDLVTVEEHLY------------------FYARVHGIPEKDIKETVHKLLRRLHL 2379
Query: 317 TPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRA--ILW--LENYLQT 372
P + + T S G + +L+ A AL +P +LLLDEP++ +D ++ LW + +Q
Sbjct: 2380 MP-FKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN 2438
Query: 373 WPSTILVVSHDRNFLNAIAT 392
S IL SH A+ T
Sbjct: 2439 KCSVIL-TSHSMEECEALCT 2457
Score = 34.3 bits (77), Expect = 0.41
Identities = 18/59 (30%), Positives = 29/59 (49%)
Query: 165 SRLESSGKNKSYDVRIENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKML 223
S +E K+ + V + +G +V + ++N G L+G NG GKTT + ML
Sbjct: 1333 SNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISML 1391
Score = 30.8 bits (68), Expect = 4.5
Identities = 36/136 (26%), Positives = 59/136 (43%), Gaps = 17/136 (12%)
Query: 523 VVGENGAGKSTMLKLLLGDLAPVRGIRHAH-RNLK---------IGYFSQHHVEQLDLNV 572
++G NGAGK+T + +L G G + +++K +G QH V L
Sbjct: 1376 LLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTT 1435
Query: 573 SAVELL--ARKFP----GRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTM 626
LL + K P + EE + L G+ R + +LSGG K +++ + +
Sbjct: 1436 KEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKR-VGTLSGGMKRKLSISIALI 1494
Query: 627 PCPNFYILDEPTNHLD 642
ILDEP+ +D
Sbjct: 1495 GGSRVVILDEPSTGVD 1510
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 49.3 bits (116), Expect = 1e-05
Identities = 49/206 (23%), Positives = 86/206 (41%), Gaps = 42/206 (20%)
Query: 492 LQLDEVDFYYDPKH--VIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRGIR 549
L+ ++V F Y + I L++ + +VG +G GKST ++L+ P G
Sbjct: 394 LEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTI 453
Query: 550 HAH----RNLKIGY------------------------FSQHHVEQLDLNVSAVELLARK 581
+ RN + Y + + +V ++ + E A +
Sbjct: 454 NIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE 513
Query: 582 FPGRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHL 641
F + +++ +G G A LSGGQK R+A A+ + P +LDE T+ L
Sbjct: 514 FIMKLPQKFDTLVGERG----------AQLSGGQKQRIAIARALVRNPKILLLDEATSAL 563
Query: 642 DMETIEALGRALNNFRGG--VILVSH 665
D E+ + AL+ R G I+++H
Sbjct: 564 DTESEAEVQAALDKAREGRTTIVIAH 589
Score = 47.0 bits (110), Expect = 6e-05
Identities = 45/175 (25%), Positives = 81/175 (46%), Gaps = 22/175 (12%)
Query: 192 LLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPAL 251
+L G ++ + G+ LVG +G GK+T ++++ + L P ++ Q++ + L
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLI--QRLYDPDEGTINIDGQDIRNFNVNYL 468
Query: 252 QSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEAD----KAPARA 307
+ ++ S +E +L + IA G + EI ++E A K P +
Sbjct: 469 REIIGVVS-QEPVL-----FSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKF 522
Query: 308 SVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRA 362
++ G + SGG + R+A+ARAL P +LLLDE T+ LD +
Sbjct: 523 DTLVGERG----------AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 567
Score = 45.4 bits (106), Expect = 2e-04
Identities = 60/237 (25%), Positives = 92/237 (38%), Gaps = 56/237 (23%)
Query: 470 VDKESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKH--VIFSRLSVSADLESRICVVGEN 527
+D SE +K PD FE + +EV F Y + + LS+ + +VG +
Sbjct: 1017 IDSYSEEGLK-PDKFEGN----ITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSS 1071
Query: 528 GAGKSTMLKLLLGDLAPVRG--------------------IRHAHRNL------------ 555
G GKST+++LL P+ G ++ L
Sbjct: 1072 GCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDC 1131
Query: 556 ----KIGYFSQHHVEQLDLNVSAVELL-ARKFPGRPEEEYRHQLGRYGISGELAMRPLAS 610
I Y V D VSA + F +Y ++G G
Sbjct: 1132 SIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKG----------TQ 1181
Query: 611 LSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGG--VILVSH 665
LSGGQK R+A A+ + P +LDE T+ LD E+ + + AL+ R G I+++H
Sbjct: 1182 LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAH 1238
Score = 43.5 bits (101), Expect = 7e-04
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 17/177 (9%)
Query: 192 LLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPAL 251
+L G + + G+ LVG +G GK+T++++L + + + Q + G
Sbjct: 1051 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQ----- 1105
Query: 252 QSVLESDSVREDLLRRERELTAQ----IAAGRAEGSEAAELAEIYAKLEEIEADKAPARA 307
E+ + LR + + +Q AE + + + ++ E + A KA A
Sbjct: 1106 ----EAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA-ANI 1160
Query: 308 SVILAGLG--FTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRA 362
+ L + ++ + T + SGG + R+A+ARAL +P +LLLDE T+ LD +
Sbjct: 1161 HPFIETLPHKYETRVGDKGT-QLSGGQKQRIAIARALIRQPQILLLDEATSALDTES 1216
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 49.3 bits (116), Expect = 1e-05
Identities = 49/206 (23%), Positives = 86/206 (41%), Gaps = 42/206 (20%)
Query: 492 LQLDEVDFYYDPKH--VIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRGIR 549
L+ ++V F Y + I L++ + +VG +G GKST ++L+ P G
Sbjct: 394 LEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTI 453
Query: 550 HAH----RNLKIGY------------------------FSQHHVEQLDLNVSAVELLARK 581
+ RN + Y + + +V ++ + E A +
Sbjct: 454 NIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE 513
Query: 582 FPGRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHL 641
F + +++ +G G A LSGGQK R+A A+ + P +LDE T+ L
Sbjct: 514 FIMKLPQKFDTLVGERG----------AQLSGGQKQRIAIARALVRNPKILLLDEATSAL 563
Query: 642 DMETIEALGRALNNFRGG--VILVSH 665
D E+ + AL+ R G I+++H
Sbjct: 564 DTESEAEVQAALDKAREGRTTIVIAH 589
Score = 48.1 bits (113), Expect = 3e-05
Identities = 60/230 (26%), Positives = 92/230 (40%), Gaps = 49/230 (21%)
Query: 470 VDKESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKH--VIFSRLSVSADLESRICVVGEN 527
+D SE +K PD FE + +EV F Y + + LS+ + +VG +
Sbjct: 970 IDSYSEEGLK-PDKFEGN----ITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSS 1024
Query: 528 GAGKSTMLKLLLGDLAPVRG-------------IRHAHRNL----------------KIG 558
G GKST+++LL P+ G ++ L I
Sbjct: 1025 GCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIA 1084
Query: 559 YFSQHHVEQLDLNVSAVELL-ARKFPGRPEEEYRHQLGRYGISGELAMRPLASLSGGQKS 617
Y V D VSA + F +Y ++G G LSGGQK
Sbjct: 1085 YGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKG----------TQLSGGQKQ 1134
Query: 618 RVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGG--VILVSH 665
R+A A+ + P +LDE T+ LD E+ + + AL+ R G I+++H
Sbjct: 1135 RIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAH 1184
Score = 47.0 bits (110), Expect = 6e-05
Identities = 45/175 (25%), Positives = 81/175 (46%), Gaps = 22/175 (12%)
Query: 192 LLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPAL 251
+L G ++ + G+ LVG +G GK+T ++++ + L P ++ Q++ + L
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLI--QRLYDPDEGTINIDGQDIRNFNVNYL 468
Query: 252 QSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEAD----KAPARA 307
+ ++ S +E +L + IA G + EI ++E A K P +
Sbjct: 469 REIIGVVS-QEPVL-----FSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKF 522
Query: 308 SVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRA 362
++ G + SGG + R+A+ARAL P +LLLDE T+ LD +
Sbjct: 523 DTLVGERG----------AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 567
Score = 45.4 bits (106), Expect = 2e-04
Identities = 47/178 (26%), Positives = 82/178 (46%), Gaps = 26/178 (14%)
Query: 192 LLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPAL 251
+L G + + G+ LVG +G GK+T++++L P ++L QE + L
Sbjct: 1004 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLL--ERFYDPLAGTVLLDGQEAKKLNVQWL 1061
Query: 252 QSVLESDSVREDLLRRERELTAQIAAG-------RAEGSEAAELAEIYAKLEEIEADKAP 304
++ L V ++ + + + IA G + E AA+ A I+ +E + P
Sbjct: 1062 RAQL--GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL-----P 1114
Query: 305 ARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRA 362
+ + G + SGG + R+A+ARAL +P +LLLDE T+ LD +
Sbjct: 1115 HKYETRVGDKG----------TQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES 1162
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 49.3 bits (116), Expect = 1e-05
Identities = 49/206 (23%), Positives = 86/206 (41%), Gaps = 42/206 (20%)
Query: 492 LQLDEVDFYYDPKH--VIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRGIR 549
L+ ++V F Y + I L++ + +VG +G GKST ++L+ P G
Sbjct: 394 LEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTI 453
Query: 550 HAH----RNLKIGY------------------------FSQHHVEQLDLNVSAVELLARK 581
+ RN + Y + + +V ++ + E A +
Sbjct: 454 NIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE 513
Query: 582 FPGRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHL 641
F + +++ +G G A LSGGQK R+A A+ + P +LDE T+ L
Sbjct: 514 FIMKLPQKFDTLVGERG----------AQLSGGQKQRIAIARALVRNPKILLLDEATSAL 563
Query: 642 DMETIEALGRALNNFRGG--VILVSH 665
D E+ + AL+ R G I+++H
Sbjct: 564 DTESEAEVQAALDKAREGRTTIVIAH 589
Score = 48.1 bits (113), Expect = 3e-05
Identities = 60/230 (26%), Positives = 92/230 (40%), Gaps = 49/230 (21%)
Query: 470 VDKESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKH--VIFSRLSVSADLESRICVVGEN 527
+D SE +K PD FE + +EV F Y + + LS+ + +VG +
Sbjct: 1017 IDSYSEEGLK-PDKFEGN----ITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSS 1071
Query: 528 GAGKSTMLKLLLGDLAPVRG-------------IRHAHRNL----------------KIG 558
G GKST+++LL P+ G ++ L I
Sbjct: 1072 GCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIA 1131
Query: 559 YFSQHHVEQLDLNVSAVELL-ARKFPGRPEEEYRHQLGRYGISGELAMRPLASLSGGQKS 617
Y V D VSA + F +Y ++G G LSGGQK
Sbjct: 1132 YGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKG----------TQLSGGQKQ 1181
Query: 618 RVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGG--VILVSH 665
R+A A+ + P +LDE T+ LD E+ + + AL+ R G I+++H
Sbjct: 1182 RIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAH 1231
Score = 47.0 bits (110), Expect = 6e-05
Identities = 45/175 (25%), Positives = 81/175 (46%), Gaps = 22/175 (12%)
Query: 192 LLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPAL 251
+L G ++ + G+ LVG +G GK+T ++++ + L P ++ Q++ + L
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLI--QRLYDPDEGTINIDGQDIRNFNVNYL 468
Query: 252 QSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEAD----KAPARA 307
+ ++ S +E +L + IA G + EI ++E A K P +
Sbjct: 469 REIIGVVS-QEPVL-----FSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKF 522
Query: 308 SVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRA 362
++ G + SGG + R+A+ARAL P +LLLDE T+ LD +
Sbjct: 523 DTLVGERG----------AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 567
Score = 45.4 bits (106), Expect = 2e-04
Identities = 47/178 (26%), Positives = 82/178 (46%), Gaps = 26/178 (14%)
Query: 192 LLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPAL 251
+L G + + G+ LVG +G GK+T++++L P ++L QE + L
Sbjct: 1051 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLL--ERFYDPLAGTVLLDGQEAKKLNVQWL 1108
Query: 252 QSVLESDSVREDLLRRERELTAQIAAG-------RAEGSEAAELAEIYAKLEEIEADKAP 304
++ L V ++ + + + IA G + E AA+ A I+ +E + P
Sbjct: 1109 RAQL--GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL-----P 1161
Query: 305 ARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRA 362
+ + G + SGG + R+A+ARAL +P +LLLDE T+ LD +
Sbjct: 1162 HKYETRVGDKG----------TQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES 1209
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 48.9 bits (115), Expect = 2e-05
Identities = 51/192 (26%), Positives = 86/192 (44%), Gaps = 33/192 (17%)
Query: 178 VRIENFDVSFGD-RVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKML------ATRSLRV 230
+ EN S+ D R L + G+ LVG +G GK+T+L++L ++ +R+
Sbjct: 590 IEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRI 649
Query: 231 PAHISLLHVEQEVAGDDTPALQS---VLESDSVREDLLRRERELTAQIAAGRAEGSEAAE 287
Q+++ +L+S V+ D+V + + ++ AG E AA+
Sbjct: 650 DG--------QDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQ 701
Query: 288 LAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPD 347
A I+ + I A R V GL + SGG + R+A+AR + P
Sbjct: 702 AAGIH---DAIMAFPEGYRTQVGERGL------------KLSGGEKQRVAIARTILKAPG 746
Query: 348 LLLLDEPTNMLD 359
++LLDE T+ LD
Sbjct: 747 IILLDEATSALD 758
Score = 48.1 bits (113), Expect = 3e-05
Identities = 55/212 (25%), Positives = 78/212 (36%), Gaps = 41/212 (19%)
Query: 472 KESEVVMKFPD-GFEKFSPPILQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAG 530
KE V P G +F ++ + V F Y +S + + +VG +GAG
Sbjct: 569 KEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAG 628
Query: 531 KSTMLKLLLG-----------DLAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLA 579
KST+L+LL D + + A IG Q V D +
Sbjct: 629 KSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRY-G 687
Query: 580 RKFPGRPEEE------------------YRHQLGRYGISGELAMRPLASLSGGQKSRVAF 621
R G E E YR Q+G G+ LSGG+K RVA
Sbjct: 688 RVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLK----------LSGGEKQRVAI 737
Query: 622 AQMTMPCPNFYILDEPTNHLDMETIEALGRAL 653
A+ + P +LDE T+ LD A+ +L
Sbjct: 738 ARTILKAPGIILLDEATSALDTSNERAIQASL 769
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 48.5 bits (114), Expect = 2e-05
Identities = 46/170 (27%), Positives = 71/170 (41%), Gaps = 17/170 (10%)
Query: 192 LLAGADVNLAW--GRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTP 249
++A D++L G +GL+G NG GK+T KML H + + +
Sbjct: 4734 IIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSA 4793
Query: 250 ALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASV 309
VL ++D L + LT E Y L I P A
Sbjct: 4794 GTAGVLIGYCPQQDAL--DELLTGW------------EHLYYYCSLRGIPRQCIPEVAGD 4839
Query: 310 ILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLD 359
++ L + P +SGG + +L+ A AL +PD+LLLDEP++ +D
Sbjct: 4840 LIRRLHLEAHADK-PVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMD 4888
Score = 42.7 bits (99), Expect = 0.001
Identities = 50/195 (25%), Positives = 86/195 (44%), Gaps = 17/195 (8%)
Query: 488 SPPILQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRG 547
S P + L V Y+ + LS++ + ++G NGAGK+T++ +L G P G
Sbjct: 3838 SAPGVTLVSVTKEYEGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSG 3897
Query: 548 -IRHAHRNL---------KIGYFSQHHVEQLDLNVSAVELL--ARKFPGRPEEEYRHQLG 595
I +NL ++G Q + +L V LL + K P ++E Q+
Sbjct: 3898 TIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVN 3957
Query: 596 RYGISGELAM---RPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRA 652
+ +L + +LSGG K +++ M +LDEPT+ +D + +L
Sbjct: 3958 QTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDI 4017
Query: 653 LNNFRGG--VILVSH 665
L +R G +I +H
Sbjct: 4018 LLKYREGRTIIFTTH 4032
Score = 41.6 bits (96), Expect = 0.003
Identities = 50/185 (27%), Positives = 79/185 (42%), Gaps = 28/185 (15%)
Query: 523 VVGENGAGKSTMLKLLLGDLAPVRGIRHA----------------HRNLKIGYFSQHHVE 566
++G NGAGKST K+L G+++ G HA + IGY Q +
Sbjct: 4752 LLGVNGAGKSTTFKMLNGEVSLTSG--HAIIRTPMGDAVDLSSAGTAGVLIGYCPQQ--D 4807
Query: 567 QLDLNVSAVELL-----ARKFPGRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAF 621
LD ++ E L R P + E L R A +P+A+ SGG K +++
Sbjct: 4808 ALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLST 4867
Query: 622 AQMTMPCPNFYILDEPTNHLDMETIEALGRA-LNNFRGG--VILVSHDERFIRLVCRELW 678
A + P+ +LDEP++ +D + L + + R G +L SH +C L
Sbjct: 4868 ALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLA 4927
Query: 679 VCEGG 683
+ G
Sbjct: 4928 IMVNG 4932
Score = 40.4 bits (93), Expect = 0.006
Identities = 51/206 (24%), Positives = 87/206 (42%), Gaps = 37/206 (17%)
Query: 208 LVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDT---------PALQSVLESD 258
L+G NG GKTT++ ML L P +++ + + D + P +L++
Sbjct: 3873 LLGTNGAGKTTIISMLT--GLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNL 3930
Query: 259 SVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTP 318
+VRE LL L A I A + E + ++ L++++ +
Sbjct: 3931 TVREHLL-----LFASIKAPQWTKKELHQ--QVNQTLQDVDLTQH--------------- 3968
Query: 319 KMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLD--VRAILWLENYLQTWPST 376
Q + TR SGG + +L+L A ++LDEPT+ +D R LW T
Sbjct: 3969 --QHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRT 4026
Query: 377 ILVVSHDRNFLNAIATDIIHLHSQRL 402
I+ +H + A++ + L RL
Sbjct: 4027 IIFTTHHLDEAEALSDRVAVLQHGRL 4052
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,862,424
Number of Sequences: 37866
Number of extensions: 1075116
Number of successful extensions: 5219
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 94
Number of HSP's successfully gapped in prelim test: 56
Number of HSP's that attempted gapping in prelim test: 4636
Number of HSP's gapped (non-prelim): 559
length of query: 709
length of database: 18,247,518
effective HSP length: 109
effective length of query: 600
effective length of database: 14,120,124
effective search space: 8472074400
effective search space used: 8472074400
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.