Guide to the Human Genome
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Search of human proteins with 14719835

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14719835 NLR family, pyrin domain containing 1 isoform 4
[Homo sapiens]
         (1399 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom...  2850   0.0  
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo...  2835   0.0  
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom...  2829   0.0  
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom...  2813   0.0  
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom...  2570   0.0  
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho...   488   e-137
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho...   461   e-129
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom...   461   e-129
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho...   461   e-129
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho...   440   e-123
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom...   434   e-121
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]     423   e-118
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H...   343   9e-94
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]      337   6e-92
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]       327   6e-89
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof...   327   6e-89
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]     323   5e-88
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]   322   2e-87
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso...   316   1e-85
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof...   316   1e-85
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]      296   7e-80
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]      281   3e-75
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]     252   2e-66
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]    250   8e-66
gi|7662404 caspase recruitment domain family, member 8 [Homo sap...   248   3e-65
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho...   144   5e-34
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]          130   7e-30
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]          130   7e-30
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]          130   7e-30
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]          130   7e-30

>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
            sapiens]
          Length = 1399

 Score = 2850 bits (7389), Expect = 0.0
 Identities = 1399/1399 (100%), Positives = 1399/1399 (100%)

Query: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
            MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60

Query: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
            YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120

Query: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
            IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180

Query: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
            AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240

Query: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
            PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300

Query: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
            PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360

Query: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
            FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420

Query: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
            EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480

Query: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
            FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540

Query: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
            TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600

Query: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
            ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660

Query: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
            GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720

Query: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
            CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780

Query: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
            PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840

Query: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
            TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900

Query: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS 960
            LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS
Sbjct: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS 960

Query: 961  VMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPE 1020
            VMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPE
Sbjct: 961  VMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPE 1020

Query: 1021 VVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRW 1080
            VVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRW
Sbjct: 1021 VVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRW 1080

Query: 1081 PNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFV 1140
            PNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFV
Sbjct: 1081 PNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFV 1140

Query: 1141 ALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIP 1200
            ALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIP
Sbjct: 1141 ALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIP 1200

Query: 1201 VTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKELELCYRSPGEDQLFSEFYVGHLGSGIRL 1260
            VTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKELELCYRSPGEDQLFSEFYVGHLGSGIRL
Sbjct: 1201 VTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKELELCYRSPGEDQLFSEFYVGHLGSGIRL 1260

Query: 1261 QVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVT 1320
            QVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVT
Sbjct: 1261 QVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVT 1320

Query: 1321 SVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPH 1380
            SVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPH
Sbjct: 1321 SVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPH 1380

Query: 1381 LIMELWEKGSKKGLLPLSS 1399
            LIMELWEKGSKKGLLPLSS
Sbjct: 1381 LIMELWEKGSKKGLLPLSS 1399


>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
            sapiens]
          Length = 1429

 Score = 2835 bits (7348), Expect = 0.0
 Identities = 1399/1429 (97%), Positives = 1399/1429 (97%), Gaps = 30/1429 (2%)

Query: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
            MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60

Query: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
            YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120

Query: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
            IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180

Query: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
            AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240

Query: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
            PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300

Query: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
            PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360

Query: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
            FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420

Query: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
            EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480

Query: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
            FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540

Query: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
            TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600

Query: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
            ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660

Query: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
            GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720

Query: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
            CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780

Query: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
            PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840

Query: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
            TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900

Query: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--- 957
            LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG   
Sbjct: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960

Query: 958  ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 990
                                       KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 961  TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020

Query: 991  ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1050
            ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
Sbjct: 1021 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1080

Query: 1051 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1110
            GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
Sbjct: 1081 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1140

Query: 1111 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1170
            PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
Sbjct: 1141 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1200

Query: 1171 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1230
            ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
Sbjct: 1201 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1260

Query: 1231 KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPP 1290
            KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPP
Sbjct: 1261 KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPP 1320

Query: 1291 ARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPS 1350
            ARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPS
Sbjct: 1321 ARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPS 1380

Query: 1351 QMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1399
            QMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
Sbjct: 1381 QMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1429


>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
            sapiens]
          Length = 1443

 Score = 2829 bits (7334), Expect = 0.0
 Identities = 1399/1443 (96%), Positives = 1399/1443 (96%), Gaps = 44/1443 (3%)

Query: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
            MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60

Query: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
            YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120

Query: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
            IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180

Query: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
            AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240

Query: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
            PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300

Query: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
            PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360

Query: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
            FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420

Query: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
            EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480

Query: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
            FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540

Query: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
            TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600

Query: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
            ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660

Query: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
            GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720

Query: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
            CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780

Query: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
            PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840

Query: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
            TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900

Query: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS 960
            LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS
Sbjct: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS 960

Query: 961  VMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPE 1020
            VMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPE
Sbjct: 961  VMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPE 1020

Query: 1021 VVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRW 1080
            VVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRW
Sbjct: 1021 VVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRW 1080

Query: 1081 PNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFV 1140
            PNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFV
Sbjct: 1081 PNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFV 1140

Query: 1141 ALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIP 1200
            ALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIP
Sbjct: 1141 ALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIP 1200

Query: 1201 VTSVVLLYHRVHPEEVTFHLYLIPSDCSIR------------------------------ 1230
            VTSVVLLYHRVHPEEVTFHLYLIPSDCSIR                              
Sbjct: 1201 VTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRY 1260

Query: 1231 --------------KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALV 1276
                          KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALV
Sbjct: 1261 TVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALV 1320

Query: 1277 KPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQ 1336
            KPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQ
Sbjct: 1321 KPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQ 1380

Query: 1337 EQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLP 1396
            EQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLP
Sbjct: 1381 EQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLP 1440

Query: 1397 LSS 1399
            LSS
Sbjct: 1441 LSS 1443


>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 1473

 Score = 2813 bits (7293), Expect = 0.0
 Identities = 1399/1473 (94%), Positives = 1399/1473 (94%), Gaps = 74/1473 (5%)

Query: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
            MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60

Query: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
            YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120

Query: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
            IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180

Query: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
            AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240

Query: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
            PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300

Query: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
            PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360

Query: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
            FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420

Query: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
            EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480

Query: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
            FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540

Query: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
            TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600

Query: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
            ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660

Query: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
            GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720

Query: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
            CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780

Query: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
            PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840

Query: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
            TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900

Query: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--- 957
            LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG   
Sbjct: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960

Query: 958  ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 990
                                       KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 961  TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020

Query: 991  ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1050
            ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
Sbjct: 1021 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1080

Query: 1051 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1110
            GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
Sbjct: 1081 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1140

Query: 1111 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1170
            PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
Sbjct: 1141 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1200

Query: 1171 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1230
            ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
Sbjct: 1201 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1260

Query: 1231 --------------------------------------------KELELCYRSPGEDQLF 1246
                                                        KELELCYRSPGEDQLF
Sbjct: 1261 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF 1320

Query: 1247 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1306
            SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
Sbjct: 1321 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1380

Query: 1307 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1366
            FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
Sbjct: 1381 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1440

Query: 1367 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1399
            KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
Sbjct: 1441 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1473


>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
            sapiens]
          Length = 1375

 Score = 2570 bits (6661), Expect = 0.0
 Identities = 1279/1357 (94%), Positives = 1279/1357 (94%), Gaps = 78/1357 (5%)

Query: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
            MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60

Query: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
            YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120

Query: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
            IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180

Query: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
            AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240

Query: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
            PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300

Query: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
            PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360

Query: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
            FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420

Query: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
            EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480

Query: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
            FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540

Query: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
            TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600

Query: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
            ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660

Query: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
            GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720

Query: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
            CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780

Query: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
            PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840

Query: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
            TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900

Query: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--- 957
            LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG   
Sbjct: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960

Query: 958  ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 990
                                       KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 961  TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020

Query: 991  ASHVAQANLKLLDVSKIFPIAEIA----EESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1046
            ASHVAQANLKLLDVSKIFPIAEIA    EESSPEVVPVELLCVPSPASQGDLHTKPLGTD
Sbjct: 1021 ASHVAQANLKLLDVSKIFPIAEIAGKSHEESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1080

Query: 1047 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1106
            DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL
Sbjct: 1081 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1140

Query: 1107 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1166
            GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK
Sbjct: 1141 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1200

Query: 1167 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1226
            PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD
Sbjct: 1201 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1260

Query: 1227 CSIR--------------------------------------------KELELCYRSPGE 1242
            CSIR                                            KELELCYRSPGE
Sbjct: 1261 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1320

Query: 1243 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1279
            DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG
Sbjct: 1321 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1357


>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
           sapiens]
          Length = 1061

 Score =  488 bits (1255), Expect = e-137
 Identities = 298/717 (41%), Positives = 413/717 (57%), Gaps = 46/717 (6%)

Query: 273 DFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHL---------IEIRDLFGPGLD 323
           + + ++T+LLL++       +P+  +     ++  RGH          I+I  LF P  +
Sbjct: 152 NLSHRYTRLLLVKE----HSNPMQVQQ--QLLDTGRGHARTVGHQASPIKIETLFEPDEE 205

Query: 324 TQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKV-VSLA 381
             EP R V++QGAAGIGKS LA +V   W  G+L+  RF ++FY +CRE+ QS    S+ 
Sbjct: 206 RPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQ 265

Query: 382 ELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLG 441
           +LI        AP+++++  PERLLFI+DG DE      +P    CL W + +P + LL 
Sbjct: 266 DLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLN 325

Query: 442 SLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAI 501
           SL+ K +LPE S LIT R TAL+ L   LE  R VE+LGFSE+ RKEYFY+YF +  QA 
Sbjct: 326 SLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAG 385

Query: 502 RAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQA 561
           + F  V+ N+ L+ +C VP V W+ CTCL QQ++    L  TS+TTT + + YL   +Q 
Sbjct: 386 QVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQP 445

Query: 562 QPLGPQL------RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH-P 614
           +P  P+L      R LCSLAA+G+W +K LF   DLRKHGLDG  +S FL M I Q+   
Sbjct: 446 KPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDIN 505

Query: 615 IPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTR 672
               YSFIHL FQEFFAAM Y+L E E G G       D+ + L  Y      F A T+R
Sbjct: 506 CERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQ----DVTRLLTEYAFSERSFLALTSR 561

Query: 673 FLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQ----LLLQPHSLESLHCLYETR 726
           FL GLL++E    +E     ++S     +L+QW+ S        LQ  SLE   CLYE +
Sbjct: 562 FLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQ 621

Query: 727 NKTFLTQVMAHFEEMGMC-VETDMELLVCTFCIKFSRHVKKLQLI--------EGRQHRS 777
            + F+ Q ++HF+ + +  + + ME +V +FC+K  R  + L L         E R   S
Sbjct: 622 EEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCS 681

Query: 778 TWSPTMVV-LFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPR 836
             + T++V L     + DAY + L + L    NL EL L  N+L    VK LC+ LR P 
Sbjct: 682 AGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPN 741

Query: 837 CLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKL 896
           C L+ LRL  C +++  C+DL+  L AN+ LT +DLS N +   G   LC+ LR P C+L
Sbjct: 742 CKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRL 801

Query: 897 QRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           Q +QL  C L S  CQ++ASVL  +P L ELDL  N L+D+G+RLLC+GLRHP C+L
Sbjct: 802 QMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRL 858



 Score =  145 bits (367), Expect = 2e-34
 Identities = 77/160 (48%), Positives = 101/160 (63%), Gaps = 2/160 (1%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L + L   +NL  +DLSGN +    +  LC+ LR P+C L+ ++L  C L +  C+++A 
Sbjct: 762 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 821

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            L  N  L ELDL+ N L D G + LCQ LR P C+L+ L L  C LT+  C +LAS LS
Sbjct: 822 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 881

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL--IRLG 957
            + SL+ELDL  N L D+GV LLCEGLRHP CKL  +RLG
Sbjct: 882 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLG 921



 Score =  145 bits (365), Expect = 3e-34
 Identities = 81/159 (50%), Positives = 103/159 (64%)

Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
           Q + SVL    +L ELDL+GN+L    ++ LC+ LR P C L TL L  C LTA  C +L
Sbjct: 817 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876

Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
           A  L  NQ+L ELDLS N L D G   LC+ LR P+CKLQ L+L  C L S  C+ L+ V
Sbjct: 877 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936

Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
           L A+ +L+ELDL  N+L D G+ LL EGL+HPAC+L +L
Sbjct: 937 LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKL 975



 Score =  139 bits (349), Expect = 2e-32
 Identities = 78/162 (48%), Positives = 100/162 (61%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T A    L S L V ++L+ELDLS N L    V  LC+ LR P C L+TLRL  C L +
Sbjct: 868  LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGS 927

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C+ L+  L+AN  L ELDLSFN L D G   L + L+ P+C+LQ+L L SCGLT+  C
Sbjct: 928  AACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKAC 987

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
            ++L   L  + +L +L L  N L D GVRLLC+ L HP CKL
Sbjct: 988  ENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKL 1029



 Score = 90.9 bits (224), Expect = 8e-18
 Identities = 53/122 (43%), Positives = 69/122 (56%)

Query: 803  VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
            VL+   NL+ELDLS N L    +  L + L+ P C L+ L L  CGLTA+ C++L F L 
Sbjct: 936  VLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLG 995

Query: 863  ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
             NQTLT+L L+ N L D G + LC+RL  P CKL+ L L    L       LA++    P
Sbjct: 996  INQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKP 1055

Query: 923  SL 924
             L
Sbjct: 1056 YL 1057



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 48/165 (29%), Positives = 75/165 (45%), Gaps = 6/165 (3%)

Query: 8   RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRA 66
           RL+ YLE L+  ELK+F+L L     +    G+ P    EK   +E+A  L+  +G + A
Sbjct: 12  RLSTYLEELEAVELKKFKLYLGTA--TELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69

Query: 67  WDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPWIHELPA 126
           W LAL T+E++  + L  + Q       + P  PS   LG+ S      V +    + P 
Sbjct: 70  WRLALSTFERINRKDLWERGQREDLVRDTPPGGPSS--LGNQS-TCLLEVSLVTPRKDPQ 126

Query: 127 GCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQ 171
              +   RR  R + D + R    ++ S  Y  L    +H +P Q
Sbjct: 127 ETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQ 171



 Score = 50.8 bits (120), Expect = 9e-06
 Identities = 35/98 (35%), Positives = 49/98 (50%), Gaps = 26/98 (26%)

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971
            + LA+ L  +P+L EL L +N L   GV+LLC+GLRHP CKL  L               
Sbjct: 703  EHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNL--------------- 747

Query: 972  EMSNSTSSLKRQRLGS----ERAASHVAQANLKLLDVS 1005
                    LKR R+ S    + +A+ +A  NL  +D+S
Sbjct: 748  -------RLKRCRISSSACEDLSAALIANKNLTRMDLS 778



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 27/84 (32%), Positives = 39/84 (46%), Gaps = 8/84 (9%)

Query: 769  LIEGRQHRSTWSPTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAV 825
            L EG QH     P   +   W+    +T    + L+  L + + L +L L+ N+L  + V
Sbjct: 961  LAEGLQH-----PACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGV 1015

Query: 826  KSLCKTLRRPRCLLETLRLAGCGL 849
            + LCK L  P C L  L L G  L
Sbjct: 1016 RLLCKRLSHPGCKLRVLWLFGMDL 1039


>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
           sapiens]
          Length = 1036

 Score =  461 bits (1187), Expect = e-129
 Identities = 282/692 (40%), Positives = 391/692 (56%), Gaps = 50/692 (7%)

Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262

Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322

Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382

Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442

Query: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502

Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562

Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622

Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI            
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682

Query: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805
                        K  RH+  +Q +      +  S  +V       +T ++ + LFSVL 
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738

Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865
            +++L ELDLS NSL    ++ LC+TL+ P C +  L L  CGL+ E C D++  L +NQ
Sbjct: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798

Query: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925
            L ELDLS N L D G + LC  L+   C L++L LVSC LTS CCQDLASVLS S SL 
Sbjct: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858

Query: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
            L + +N L D GV +LCE  ++P C L +LG
Sbjct: 859 RLYVGENALGDSGVAILCEKAKNPQCNLQKLG 890



 Score =  133 bits (334), Expect = 1e-30
 Identities = 78/186 (41%), Positives = 108/186 (58%), Gaps = 1/186 (0%)

Query: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
           VL   + L ELDLS N+L    ++ LC  L+   C L+ L L  C LT+  C+DLA  L 
Sbjct: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852

Query: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
            + +LT L +  N L D+G   LC++ + P C LQ+L LV+ GLTS CC  L+SVLS + 
Sbjct: 853 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912

Query: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDTGEMSNSTSSLK 981
           +L  L L+ N L D G++LLCEGL HP CKL  L   +  +T     D   +  S+ SL+
Sbjct: 913 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 972

Query: 982 RQRLGS 987
           +  LG+
Sbjct: 973 KLSLGN 978



 Score =  132 bits (331), Expect = 3e-30
 Identities = 73/166 (43%), Positives = 99/166 (59%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T A  Q L SVL  + +L  L +  N+L  S V  LC+  + P+C L+ L L   GLT+
Sbjct: 839  LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 898

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C  L+  L  NQ LT L L  N L D G K LC+ L  P CKLQ L+L +C LTS CC
Sbjct: 899  VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 958

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
             DL+++L++S SL++L L  N+L D+GV + CE L+  +C L  LG
Sbjct: 959  WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 48/133 (36%), Positives = 65/133 (48%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T      L SVL   +NL  L L GN+L    +K LC+ L  P C L+ L L  C LT+
Sbjct: 896  LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 955

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C DL+  L ++Q+L +L L  N L D G    C+ L+Q SC LQ L L       +  
Sbjct: 956  HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 1015

Query: 912  QDLASVLSASPSL 924
              L ++    P L
Sbjct: 1016 SALETLQEEKPEL 1028



 Score = 39.3 bits (90), Expect = 0.027
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68

Query: 68 DLALHTWEQMGLRSLCAQAQ 87
           +A+  +  +  R L  +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88


>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
           sapiens]
          Length = 1036

 Score =  461 bits (1187), Expect = e-129
 Identities = 282/692 (40%), Positives = 391/692 (56%), Gaps = 50/692 (7%)

Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262

Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322

Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382

Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442

Query: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502

Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562

Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622

Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI            
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682

Query: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805
                        K  RH+  +Q +      +  S  +V       +T ++ + LFSVL 
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738

Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865
            +++L ELDLS NSL    ++ LC+TL+ P C +  L L  CGL+ E C D++  L +NQ
Sbjct: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798

Query: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925
            L ELDLS N L D G + LC  L+   C L++L LVSC LTS CCQDLASVLS S SL 
Sbjct: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858

Query: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
            L + +N L D GV +LCE  ++P C L +LG
Sbjct: 859 RLYVGENALGDSGVAILCEKAKNPQCNLQKLG 890



 Score =  133 bits (334), Expect = 1e-30
 Identities = 78/186 (41%), Positives = 108/186 (58%), Gaps = 1/186 (0%)

Query: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
           VL   + L ELDLS N+L    ++ LC  L+   C L+ L L  C LT+  C+DLA  L 
Sbjct: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852

Query: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
            + +LT L +  N L D+G   LC++ + P C LQ+L LV+ GLTS CC  L+SVLS + 
Sbjct: 853 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912

Query: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDTGEMSNSTSSLK 981
           +L  L L+ N L D G++LLCEGL HP CKL  L   +  +T     D   +  S+ SL+
Sbjct: 913 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 972

Query: 982 RQRLGS 987
           +  LG+
Sbjct: 973 KLSLGN 978



 Score =  132 bits (331), Expect = 3e-30
 Identities = 73/166 (43%), Positives = 99/166 (59%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T A  Q L SVL  + +L  L +  N+L  S V  LC+  + P+C L+ L L   GLT+
Sbjct: 839  LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 898

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C  L+  L  NQ LT L L  N L D G K LC+ L  P CKLQ L+L +C LTS CC
Sbjct: 899  VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 958

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
             DL+++L++S SL++L L  N+L D+GV + CE L+  +C L  LG
Sbjct: 959  WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 48/133 (36%), Positives = 65/133 (48%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T      L SVL   +NL  L L GN+L    +K LC+ L  P C L+ L L  C LT+
Sbjct: 896  LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 955

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C DL+  L ++Q+L +L L  N L D G    C+ L+Q SC LQ L L       +  
Sbjct: 956  HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 1015

Query: 912  QDLASVLSASPSL 924
              L ++    P L
Sbjct: 1016 SALETLQEEKPEL 1028



 Score = 39.3 bits (90), Expect = 0.027
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68

Query: 68 DLALHTWEQMGLRSLCAQAQ 87
           +A+  +  +  R L  +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88


>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
           sapiens]
          Length = 979

 Score =  461 bits (1185), Expect = e-129
 Identities = 287/723 (39%), Positives = 404/723 (55%), Gaps = 51/723 (7%)

Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262

Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322

Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382

Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442

Query: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502

Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562

Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622

Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI            
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682

Query: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805
                        K  RH+  +Q +      +  S  +V       +T ++ + LFSVL 
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738

Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865
            +++L ELDLS NSL    ++ LC+TL+ P C +  L L  CGL+ E C D++  L +NQ
Sbjct: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798

Query: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925
            L ELDLS N L D G + LC  L+   C L++L LV+ GLTS CC  L+SVLS + +L 
Sbjct: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLT 858

Query: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDTGEMSNSTSSLKRQR 984
            L L+ N L D G++LLCEGL HP CKL  L   +  +T     D   +  S+ SL++  
Sbjct: 859 HLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLS 918

Query: 985 LGS 987
           LG+
Sbjct: 919 LGN 921



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 48/133 (36%), Positives = 65/133 (48%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T      L SVL   +NL  L L GN+L    +K LC+ L  P C L+ L L  C LT+
Sbjct: 839 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 898

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C DL+  L ++Q+L +L L  N L D G    C+ L+Q SC LQ L L       +  
Sbjct: 899 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 958

Query: 912 QDLASVLSASPSL 924
             L ++    P L
Sbjct: 959 SALETLQEEKPEL 971



 Score = 39.3 bits (90), Expect = 0.027
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68

Query: 68 DLALHTWEQMGLRSLCAQAQ 87
           +A+  +  +  R L  +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88


>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
           sapiens]
          Length = 979

 Score =  440 bits (1132), Expect = e-123
 Identities = 282/720 (39%), Positives = 396/720 (55%), Gaps = 45/720 (6%)

Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262

Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322

Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382

Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442

Query: 551 CLHYLAQALQAQ------PLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502

Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562

Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWV----PSLQLL 710
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622

Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL- 769
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI+    V+ L L 
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682

Query: 770 -------------IEGRQ--------HRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTR 808
                         EGR           S+ +     L R     +  + I   VL   +
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL-VLSSNQ 741

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
            L ELDLS N+L    ++ LC  L+   C L+ L L  C LT+  C+DLA  L  + +LT
Sbjct: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 801

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
            L +  N L D+G   LC++ + P C LQ+L LV+ GLTS CC  L+SVLS + +L  L 
Sbjct: 802 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 861

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDTGEMSNSTSSLKRQRLGS 987
           L+ N L D G++LLCEGL HP CKL  L   +  +T     D   +  S+ SL++  LG+
Sbjct: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGN 921



 Score =  132 bits (331), Expect = 3e-30
 Identities = 73/166 (43%), Positives = 99/166 (59%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A  Q L SVL  + +L  L +  N+L  S V  LC+  + P+C L+ L L   GLT+
Sbjct: 782 LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 841

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C  L+  L  NQ LT L L  N L D G K LC+ L  P CKLQ L+L +C LTS CC
Sbjct: 842 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 901

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
            DL+++L++S SL++L L  N+L D+GV + CE L+  +C L  LG
Sbjct: 902 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 48/133 (36%), Positives = 65/133 (48%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T      L SVL   +NL  L L GN+L    +K LC+ L  P C L+ L L  C LT+
Sbjct: 839 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 898

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C DL+  L ++Q+L +L L  N L D G    C+ L+Q SC LQ L L       +  
Sbjct: 899 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 958

Query: 912 QDLASVLSASPSL 924
             L ++    P L
Sbjct: 959 SALETLQEEKPEL 971



 Score = 39.3 bits (90), Expect = 0.027
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68

Query: 68 DLALHTWEQMGLRSLCAQAQ 87
           +A+  +  +  R L  +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88


>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
           sapiens]
          Length = 922

 Score =  434 bits (1115), Expect = e-121
 Identities = 274/689 (39%), Positives = 381/689 (55%), Gaps = 44/689 (6%)

Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262

Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322

Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382

Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442

Query: 551 CLHYLAQALQAQ------PLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502

Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562

Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWV----PSLQLL 710
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622

Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL- 769
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI+    V+ L L 
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682

Query: 770 -------------IEGRQ--------HRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTR 808
                         EGR           S+ +     L R     +  + I   VL   +
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL-VLSSNQ 741

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
            L ELDLS N+L    ++ LC  L+   C L+ L L   GLT+  C  L+  L  NQ LT
Sbjct: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLT 801

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
            L L  N L D G K LC+ L  P CKLQ L+L +C LTS CC DL+++L++S SL++L 
Sbjct: 802 HLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLS 861

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
           L  N+L D+GV + CE L+  +C L  LG
Sbjct: 862 LGNNDLGDLGVMMFCEVLKQQSCLLQNLG 890



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 48/133 (36%), Positives = 65/133 (48%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T      L SVL   +NL  L L GN+L    +K LC+ L  P C L+ L L  C LT+
Sbjct: 782 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 841

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C DL+  L ++Q+L +L L  N L D G    C+ L+Q SC LQ L L       +  
Sbjct: 842 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 901

Query: 912 QDLASVLSASPSL 924
             L ++    P L
Sbjct: 902 SALETLQEEKPEL 914



 Score = 39.3 bits (90), Expect = 0.027
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68

Query: 68 DLALHTWEQMGLRSLCAQAQ 87
           +A+  +  +  R L  +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88


>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
          Length = 1093

 Score =  423 bits (1088), Expect = e-118
 Identities = 256/651 (39%), Positives = 368/651 (56%), Gaps = 17/651 (2%)

Query: 326 EPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIG 385
           +P+IV+LQGAAG+GK+TL R+    W  G LY  RF++VFY + RE+ Q K  S A+LI 
Sbjct: 175 QPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLIS 234

Query: 386 KDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLG 445
           KD  +T  PI +I+ +P  LLFI+D  DE  +  +EP   LC  W+Q  P   L+ SLL 
Sbjct: 235 KDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLR 294

Query: 446 KTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFR 505
           K +LPEAS L+T R T  + L   L+   +VE+LG SE +R+EY Y++F D+R A++ F 
Sbjct: 295 KVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFS 354

Query: 506 LVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL------ 559
            +KSN+ L+++C VP V W ACTCL QQM++   +TLT +TTT L   Y++         
Sbjct: 355 SLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGG 414

Query: 560 -QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQ-EHPIPL 617
             + P   QLR LC +AA+GIW    +F  ++LR+ GL  + +S+F+   I+Q +     
Sbjct: 415 SPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYEN 474

Query: 618 SYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDLEKTLEAYGIHGLFGASTTRFLLG 676
            Y F HL  QEFFAAM Y+L+     G  S     DL+  L++             FL G
Sbjct: 475 CYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFG 534

Query: 677 LLSDEGEREMENIFHCRLSQ--GRNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTF 730
           LL+++  +++E  F+C++S      L+Q +  L        Q   LE  HCLYET++K F
Sbjct: 535 LLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAF 594

Query: 731 LTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWV 790
           ++Q M  F ++ + +   + LLV +FC+K  R ++ ++L            T +    W 
Sbjct: 595 ISQAMRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWD 654

Query: 791 PVTDAY-WQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL 849
                + WQ L SVL    +L+ELDL  ++L  SA+  L   LR P C L+ L L     
Sbjct: 655 GDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITF 714

Query: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSD 909
             + C+D++  L  N+ L  LDL  + + D G K LC+ L+ P CKLQ L+L SC LT  
Sbjct: 715 -PDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVF 773

Query: 910 CCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS 960
           CC ++++ L  S SL  L+L  NNL D GV+LLCE LRHP C L RL   S
Sbjct: 774 CCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLES 824



 Score =  128 bits (321), Expect = 4e-29
 Identities = 70/166 (42%), Positives = 98/166 (59%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + L   L   + L  L L+ N L    VK +   L+  +C L++L L  C  T+
Sbjct: 827 LTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTS 886

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              + L+  L  N++LT LDL  N L D G K LC   R PSC LQ L+L+ C LT+ CC
Sbjct: 887 LSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACC 946

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
            DLASV+  +P+L+ LDL  N+L D GV++LC+ LR+P C + RLG
Sbjct: 947 LDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLG 992



 Score =  124 bits (310), Expect = 8e-28
 Identities = 72/160 (45%), Positives = 89/160 (55%)

Query: 798  QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
            + L + L   ++L  LDL  N L  + VK LC   R P C L+ L L GC LT   C DL
Sbjct: 890  EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949

Query: 858  AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
            A  +  N  L  LDL  N L D G K LC  LR P+C +QRL L  CGLTS CCQDL+S 
Sbjct: 950  ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSA 1009

Query: 918  LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
            L  +  L +++L QN L   G+  L + L+ P CKL  LG
Sbjct: 1010 LICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLG 1049



 Score =  111 bits (278), Expect = 4e-24
 Identities = 71/182 (39%), Positives = 100/182 (54%), Gaps = 1/182 (0%)

Query: 807 TRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQT 866
           +++L  L+LS N+L    V+ LC+ LR P+C LE L L  CGLT   C+ L+  L +N+ 
Sbjct: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844

Query: 867 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE 926
           LT L L+ NVL D G K +   L+   C L+ L L  C  TS   + L++ L  + SL  
Sbjct: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904

Query: 927 LDLQQNNLDDVGVRLLCEGLRHPACKLIRLG-KPSVMTPTEGLDTGEMSNSTSSLKRQRL 985
           LDL  N L D GV+LLC+  RHP+C L  L     V+T    LD   +  +  +L+   L
Sbjct: 905 LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDL 964

Query: 986 GS 987
           G+
Sbjct: 965 GN 966



 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 53/147 (36%), Positives = 77/147 (52%), Gaps = 1/147 (0%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T+A    L SV+    NL+ LDL  N L    VK LC  LR P C ++ L L  CGLT+
Sbjct: 941  LTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTS 1000

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C+DL+  L  N+ L +++L+ N L   G   L + L+ P CKLQ L L       +  
Sbjct: 1001 LCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQ 1060

Query: 912  QDLASVLSASPSL-KELDLQQNNLDDV 937
            + L +V  ++P L  + D   +N +DV
Sbjct: 1061 KLLEAVGVSNPHLIIKPDCNYHNEEDV 1087



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 3/81 (3%)

Query: 9  LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGME-VASYLVAQYGEQRAW 67
          L  YLE L KEEL  F+L L  K       G TP    K +  E +A+ +   Y  ++AW
Sbjct: 15 LLLYLEELNKEELNTFKLFL--KETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAW 72

Query: 68 DLALHTWEQMGLRSLCAQAQE 88
           ++L  + +M L+ LC +A+E
Sbjct: 73 SVSLKIFGKMNLKDLCERAKE 93


>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
           sapiens]
          Length = 1043

 Score =  343 bits (879), Expect = 9e-94
 Identities = 240/768 (31%), Positives = 362/768 (47%), Gaps = 102/768 (13%)

Query: 299 SWP-DYV---EENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRG 354
           SWP D+V     ++    E++ L  P     + + ++L G AG+GK+TLA Q    W  G
Sbjct: 196 SWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANG 255

Query: 355 QLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE 414
            L+  RF +VFY SC ++   K  + AELI  D     API + +S+PE+LLFI+DG +E
Sbjct: 256 VLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEE 315

Query: 415 PGWVLQEPSSEL------CLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIP 468
              ++ E  SE       C  W Q  P   +L SLL K ++P A+ LIT +T  +++L  
Sbjct: 316 --IIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKA 373

Query: 469 SLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACT 528
           SL    +V++ GF+    + YF R+F D  +  +  + ++ N+ L+  C  P V W  C+
Sbjct: 374 SLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCS 433

Query: 529 CLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLG-------PQLRDLCSLAAEGIWQ 581
           CL Q   R   L   ++TTT+L  ++ +       +         Q R LCSLA EG+W 
Sbjct: 434 CLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWS 493

Query: 582 KKTLFSPDDLRKHGLDGAIISTFLKMGILQE-HPIPLSYSFIHLCFQEFFAAMSYVLEDE 640
               F+ +D    GL+   I +  +  ILQ+ +      +F HL FQEFFAAMS+VLE+ 
Sbjct: 494 MNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEP 553

Query: 641 KGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG-- 697
           +    HS    +++  L+   +    +      F  GLL+    RE+E+  HC++S    
Sbjct: 554 REFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVM 613

Query: 698 RNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLV 753
             L++W   L       LQ H L   HCL+E++ + F  +++    E+ + +  D EL  
Sbjct: 614 EELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQA 673

Query: 754 CTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDA--------YWQILFSVLK 805
            +FC+K  + + KL+L          S +  +L R + + +          W  + S L 
Sbjct: 674 SSFCLKHCKRLNKLRL----------SVSSHILERDLEILETSKFDSRMHAWNSICSTLV 723

Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC---------------------------- 837
              NL ELDLS + L  S+VK LC  L+ PRC                            
Sbjct: 724 TNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSK 783

Query: 838 -----------------LLETLRLAGC----------GLTAEDCKDLAFGLRANQTLTEL 870
                            +L+ LR + C           L+A  C+DLA  L + Q +T L
Sbjct: 784 LTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRL 843

Query: 871 DLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQ 930
            L FN L D G K LC  L  P C L+RL+L  C L +  C+ L+  L  + SL  L+L 
Sbjct: 844 CLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLS 903

Query: 931 QNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTGEMSNSTS 978
           +N+L D GV+ LCE L  P   L  L         EG   GE++N+ S
Sbjct: 904 KNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREG--CGELANALS 949



 Score =  122 bits (306), Expect = 2e-27
 Identities = 72/158 (45%), Positives = 91/158 (57%), Gaps = 1/158 (0%)

Query: 800  LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
            L   L   R+L  L+LS NSL    VK LC+ L RP   L++L L+GC  T E C +LA 
Sbjct: 887  LSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELAN 946

Query: 860  GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
             L  N  +  LDL  N L D G K LC+ L+ P   L  L L  C LT+ CCQ L SVLS
Sbjct: 947  ALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLS 1005

Query: 920  ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
            +S SL  L+L  N LD  GV++LC+ L+   C+L +LG
Sbjct: 1006 SSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG 1043



 Score =  118 bits (295), Expect = 5e-26
 Identities = 77/190 (40%), Positives = 103/190 (54%), Gaps = 5/190 (2%)

Query: 800  LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
            L S+  VTR    L L  N L    +K LC  L  P+C LE L L  C L A  CK L+ 
Sbjct: 834  LTSIQHVTR----LCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSD 889

Query: 860  GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
             L  N++LT L+LS N L D G K LC+ L +P   LQ L L  C  T + C +LA+ LS
Sbjct: 890  ALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALS 949

Query: 920  ASPSLKELDLQQNNLDDVGVRLLCEGLR-HPACKLIRLGKPSVMTPTEGLDTGEMSNSTS 978
             + ++K LDL +N+L D GV+LLCE L+ H A   + L K ++ T         +S+S S
Sbjct: 950  HNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKS 1009

Query: 979  SLKRQRLGSE 988
             +    LG+E
Sbjct: 1010 LVNLNLLGNE 1019



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 23/51 (45%), Positives = 31/51 (60%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETL 842
            +T A  Q LFSVL  +++L  L+L GN L    VK LCK L++  C L+ L
Sbjct: 992  LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042


>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
          Length = 991

 Score =  337 bits (863), Expect = 6e-92
 Identities = 254/828 (30%), Positives = 386/828 (46%), Gaps = 107/828 (12%)

Query: 216 YTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHP----WEPSVRESLC----STW 267
           + E+ ++  EK E    PWA +     +    L   H+P    WE ++   L       W
Sbjct: 26  FKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTLNLFLQINRKDLW 85

Query: 268 PWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW-----PD--YVEENRGHLIEIRDLFGP 320
               E+   K        R H +    L+         P+  Y E  +    E+ D +  
Sbjct: 86  TKAQEEMRNKLNPY----RKHMKETFQLIWEKETCLHVPEHFYKETMKNEYKELNDAYTA 141

Query: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSL 380
                    V+L+G  GIGK+TL R+V   W  G L+ DRF  VF+ +  E+      SL
Sbjct: 142 AA---RRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSL 198

Query: 381 AELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALL 440
            EL+ +D   +   I  I S+PER+LFI+DG ++  + LQ   ++L   W Q QP   +L
Sbjct: 199 LELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQL-KADLSDDWRQRQPMPIIL 257

Query: 441 GSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQA 500
            SLL K +LPE+S LI     A+Q     L   + +++LGFSES +K YF  +F ++ +A
Sbjct: 258 SSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKA 317

Query: 501 IRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQ 560
           ++ F  V+ N  L+ LC  P+  WL CTC+ Q+++R E L + S+ TT L   +L    +
Sbjct: 318 LKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFK 377

Query: 561 A--QPLGP-----QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH 613
           A  Q   P     +L+ LC+LAAEGIW    +FS  DLR++GL  +    ++ M +LQ  
Sbjct: 378 AGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRR 437

Query: 614 PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS---------NCIIDLEKTLEAYGIHG 664
                ++F+HLC QEF AAM Y+L+  K     +           ++  +  L   GI  
Sbjct: 438 GD--CFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQVGI-- 493

Query: 665 LFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL----ES 718
                   F+ G+ ++E    +E  F   LS+   + + Q + SL             E 
Sbjct: 494 --------FMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQEL 545

Query: 719 LHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL--------- 769
              L+ET+ K F+T+VM  FEE+ + +     L++ +FC+K  +H+  L++         
Sbjct: 546 FIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIFPDD 605

Query: 770 ----------------------------IEGRQHRSTWSPTMVVL----------FRWVP 791
                                       I   ++ S   P++ +L           R + 
Sbjct: 606 SGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI 665

Query: 792 VTDAYW---QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCG 848
            T  Y+     LF  +    +LK L L G SLS S ++ LC+TL+ P C +E L L  C 
Sbjct: 666 FTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCD 725

Query: 849 LTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTS 908
           +++E C+D+A  L  N  L  L L  N L D G   LC+ L+   C L+RL L+ C LTS
Sbjct: 726 ISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTS 785

Query: 909 DCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
             C  ++ VL  S SL  LDL  N L+D GV  LC  L+HP C +  L
Sbjct: 786 VSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIREL 833



 Score =  124 bits (310), Expect = 8e-28
 Identities = 66/155 (42%), Positives = 88/155 (56%)

Query: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
           VL  +++L  LDL  N+L  + V SLC  L+ P C +  L L GC LT++ CKD+A  L 
Sbjct: 794 VLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853

Query: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
            N  L  L L  N + D G + LC  L+ P CKL+ L L +C +T  CC D+A+ L A  
Sbjct: 854 CNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACK 913

Query: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
           +L+ L+L    LD   V +LCE L HP C L  LG
Sbjct: 914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLG 948



 Score =  122 bits (306), Expect = 2e-27
 Identities = 66/156 (42%), Positives = 86/156 (55%)

Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
           SVL     LK L L  N L    +  LC+ L+   C LE L L  C LT+  C  ++  L
Sbjct: 736 SVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVL 795

Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
             +++L+ LDL  N L D G   LC  L+ P C ++ L L+ C LTSD C+D+A+VL  +
Sbjct: 796 LCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICN 855

Query: 922 PSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
             LK L L  N + D GVR LC  L+HP CKL  LG
Sbjct: 856 GKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLG 891



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 44/123 (35%), Positives = 57/123 (46%)

Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
           +VL     LK L L  N +  + V+ LC  L+ P C LE L L  C +T   C D+A  L
Sbjct: 850 AVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAAL 909

Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
            A +TL  L+L +  L       LC+ L  P C LQ L L   G   +  + L SV    
Sbjct: 910 IACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKI 969

Query: 922 PSL 924
           P L
Sbjct: 970 PHL 972



 Score = 38.9 bits (89), Expect = 0.035
 Identities = 25/80 (31%), Positives = 41/80 (51%)

Query: 9  LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
          L  YL+ L+KEE  +F+ LL              A+ +K S  +VA  L   Y  ++AW+
Sbjct: 11 LLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWE 70

Query: 69 LALHTWEQMGLRSLCAQAQE 88
          + L+ + Q+  + L  +AQE
Sbjct: 71 VTLNLFLQINRKDLWTKAQE 90



 Score = 34.3 bits (77), Expect = 0.86
 Identities = 22/67 (32%), Positives = 31/67 (46%)

Query: 791 PVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
           P+T A    + + L   + L+ L+L   +L   AV  LC+ L  P C L+ L L   G  
Sbjct: 896 PITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFD 955

Query: 851 AEDCKDL 857
            E  K L
Sbjct: 956 EETQKIL 962


>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
          Length = 1062

 Score =  327 bits (837), Expect = 6e-89
 Identities = 242/747 (32%), Positives = 371/747 (49%), Gaps = 84/747 (11%)

Query: 330  VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
            V+L G AG+GK+TLA+++   W    L   +F++ FY SCREL++    S AEL+ +D  
Sbjct: 209  VVLYGPAGLGKTTLAQKLMLDWAEDNLI-HKFKYAFYLSCRELSRLGPCSFAELVFRDWP 267

Query: 390  ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
                 I  IL++  ++LF++DG DE G        ++C  W + +P   LLGSLL + +L
Sbjct: 268  ELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVML 327

Query: 450  PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
            P+A+ L+T R  AL++L    E+  ++ V GF E  R+ YF R+F DE QA+RAF L++S
Sbjct: 328  PKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRS 387

Query: 510  NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL-QAQPLGPQL 568
            N  L+ L   P V W+ CT L  QM++ E    T  T T L L +L     Q   L   L
Sbjct: 388  NAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGAL 447

Query: 569  RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLS-YSFIHLCFQ 627
            R L  LAA+G+W + ++   +DL + G+  + +  FL   IL++  +    YSFIHL FQ
Sbjct: 448  RTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQ 507

Query: 628  EFFAAMSYVL--EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTR---FLLGLLSDEG 682
            +F  A+ Y L  E+E+ R  H+  I D++K L   G+  L      +   +  GL +++ 
Sbjct: 508  QFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLS--GVERLRNPDLIQAGYYSFGLANEKR 565

Query: 683  EREMENIFHCRLSQGRNLMQWVPSLQLLLQ-PHSL-----ESLHCLYETRNKTFLTQVMA 736
             +E+E  F CR+S   ++ Q +    +  +  HS      E L CLYE++ +  + +VMA
Sbjct: 566  AKELEATFGCRMSP--DIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMA 623

Query: 737  HFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL---IEGRQHRSTWSPTMVVLFRWVPVT 793
             F+E+ + +   ++++  +FC+K  R+++K+ L    E      T S +   + R     
Sbjct: 624  QFKEISLHLNA-VDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQ 682

Query: 794  D--AYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC-------------- 837
                +W  L S+    ++L  L ++ + LS S V+ LC+ +    C              
Sbjct: 683  HMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPAD 742

Query: 838  -------------------------------LLETLR----------LAGCGLTAEDCKD 856
                                           L E LR          L  C  T +   D
Sbjct: 743  AHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWAD 802

Query: 857  LAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLAS 916
            L+  L  NQ+LT ++LS N L D GAK L   LR P C LQRL L +C LT   C+DLA+
Sbjct: 803  LSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAA 862

Query: 917  VLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEG-LDTGEMSN 975
            VL  S  L  L L +N + + GV+ LCEGLR+P CKL  L   +    ++G  D  ++  
Sbjct: 863  VLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQ 922

Query: 976  STSSLKRQRLGSERAASHVAQANLKLL 1002
              SSL    LG     +H+    +K L
Sbjct: 923  EKSSLLCLDLG----LNHIGVKGMKFL 945



 Score =  125 bits (313), Expect = 4e-28
 Identities = 70/161 (43%), Positives = 91/161 (56%)

Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
           T   W  L   L+V ++L  ++LS N L     K L  TLR P+C L+ L L  C LT  
Sbjct: 796 TTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEA 855

Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
           +CKDLA  L  ++ LT L L+ N + + G K LC+ LR P CKLQ L L +C +TSD C 
Sbjct: 856 NCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCC 915

Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           DL  +L    SL  LDL  N++   G++ LCE LR P C L
Sbjct: 916 DLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNL 956



 Score =  111 bits (277), Expect = 6e-24
 Identities = 65/155 (41%), Positives = 90/155 (58%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T+A  + L +VL V+R L  L L+ N + ++ VK LC+ LR P C L+TL L  C +T+
Sbjct: 852  LTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITS 911

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
            + C DL   L+   +L  LDL  N +   G K LC+ LR+P C L+ L L  C +    C
Sbjct: 912  DGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSC 971

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGL 946
            +DL S LS + SL  LDL QN L   GV++L E L
Sbjct: 972  EDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETL 1006



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 42/125 (33%), Positives = 60/125 (48%)

Query: 800  LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
            L  +L+   +L  LDL  N +    +K LC+ LR+P C L  L L GC +    C+DL  
Sbjct: 917  LTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCS 976

Query: 860  GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
             L  NQ+L  LDL  N L  +G K L + L   S  L+ L+L       +  + L  +  
Sbjct: 977  ALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEE 1036

Query: 920  ASPSL 924
             +P L
Sbjct: 1037 KNPQL 1041


>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
           1 [Homo sapiens]
          Length = 1009

 Score =  327 bits (837), Expect = 6e-89
 Identities = 243/702 (34%), Positives = 355/702 (50%), Gaps = 75/702 (10%)

Query: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
           F P L+ + PR      V+L G AG+GK+TLA++    W    L     ++ FY SC+EL
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215

Query: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
           ++    S AELI KD       I  IL++ +R+LF++DG+DE    PG ++Q+    +C 
Sbjct: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271

Query: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
            W + +P   LLGSLL + +LP A+ L+T R  AL++L    +Q  +V V GF E  R+ 
Sbjct: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331

Query: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
           YF R+F DE QA+RAF L++SN  L+ L   P V W+ CT L  QM++ E    T  T T
Sbjct: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391

Query: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
            L L +L     Q   L   LR L  LAA+G+W + ++F  +DL + G+  + +  FL  
Sbjct: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451

Query: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
            IL++  +    YSFIHL FQ+F  A+ Y LE E+G  R  H+  I D++K L   G   
Sbjct: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509

Query: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQL---LLQPHSL 716
           L      +   FL GL +++  +E+E  F CR+S    + L+Q    L     L      
Sbjct: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK 569

Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------- 769
           E L CLYE++ +     V+A F+E+ + +    E++ C+F +K  + ++KL L       
Sbjct: 570 EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF 629

Query: 770 ----------------------IEGRQH---------------RSTWSPTMVVLFRWVPV 792
                                 +E +Q                RST     V +    P 
Sbjct: 630 LENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPD 689

Query: 793 TDAYWQILFSVLKVTRNLKELDLSGN-SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           T AY     + +   + L  L L+G+     + +  LC  LR  +C L+ LRL G   T 
Sbjct: 690 T-AYRDFCLAFIG-KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATP 747

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
           E   +  + L+ANQ+L  L LS NVL D GA  L + + +P   LQ L L +C LT   C
Sbjct: 748 EQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASC 807

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           +DLA+VL  S  L  L L +N + D GV+ LCEGL +P CKL
Sbjct: 808 KDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKL 849



 Score =  113 bits (282), Expect = 1e-24
 Identities = 70/172 (40%), Positives = 91/172 (52%), Gaps = 3/172 (1%)

Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
           T   W   F VLK  ++LK L LS N L       L KT+ RP+  L+ L L  C LT  
Sbjct: 746 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 805

Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
            CKDLA  L  ++ LT L L+ N + D G K LC+ L  P CKLQ L L  C +T   C+
Sbjct: 806 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 865

Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL--IRLGKPSVM 962
            L+  L  + SL  LDL  N +   G+ +LC+ L +P C L  +RL   S+M
Sbjct: 866 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLM 916



 Score = 97.8 bits (242), Expect = 6e-20
 Identities = 65/167 (38%), Positives = 93/167 (55%), Gaps = 3/167 (1%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + L +VL V++ L  L L+ N +  + VK LC+ L  P C L+TL L  C +T 
Sbjct: 802 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 861

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C+ L+  L+   +LT LDLS N +   G   LCQ L  P+C L+ L+L SC L    C
Sbjct: 862 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 920

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRL 956
           Q L S L ++  L+ LDL QN+L   G+  L   LR    + K++RL
Sbjct: 921 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 967



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 48/156 (30%), Positives = 71/156 (45%), Gaps = 3/156 (1%)

Query: 769 LIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSL 828
           L EG  +      T+V+  +   +T    + L   L+   +L  LDLS N ++   +  L
Sbjct: 838 LCEGLSYPDCKLQTLVL--QQCSITKLGCRYLSEALQEACSLTNLDLSINQIARG-LWIL 894

Query: 829 CKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQR 888
           C+ L  P C L+ LRL  C L    C+ L   L +NQ L  LDL  N L  +G   L   
Sbjct: 895 CQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGV 954

Query: 889 LRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSL 924
           LRQ +  L+ L+L +     +  + L  V   +P L
Sbjct: 955 LRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKL 990


>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
          Length = 994

 Score =  323 bits (829), Expect = 5e-88
 Identities = 226/719 (31%), Positives = 357/719 (49%), Gaps = 100/719 (13%)

Query: 317 LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSK 376
           LF P    ++PR VI+QG  GIGK+TL  ++  AW   +++ DRF + FYF CREL +  
Sbjct: 138 LFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELP 197

Query: 377 VVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPA 436
             SLA+LI ++     API +I+S+PERLLF++D  +E    L EP S+LC    + +P 
Sbjct: 198 PTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPV 257

Query: 437 DALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTD 496
             LL SLL K +LPEAS LI  +    + L   +  +   +  GF+ES R  YF  +F D
Sbjct: 258 QVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKD 317

Query: 497 ERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLA 556
            ++A+ AF LV+ +++L+++C +P + W+ CT L Q+M++ + L LT ++TT++   ++ 
Sbjct: 318 PKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVF 377

Query: 557 QALQAQPL-GP------QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI 609
                +   GP      QL+ LCSLAAEG+W     F  DDLR++G+  A I   L   I
Sbjct: 378 NLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKI 437

Query: 610 LQEH-PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDL-----EKTLEAYGI 662
           L ++     SY F+H+C QEF AA+ Y+L+        +  C+ +L     EK   A+ I
Sbjct: 438 LLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWI 497

Query: 663 HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPH----SL 716
               G     FL GLL+ + + +++  F  +LSQ   + + Q + SL     P     SL
Sbjct: 498 --FLGC----FLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSL 551

Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKL------QLI 770
              +CL+E ++  F+ Q +   +E    +  +++L+V  +C+K+   ++KL         
Sbjct: 552 AIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFK 611

Query: 771 EGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCK 830
           +  +H ST   +++            W  + SVL  + +L+EL +  ++LS S   + C 
Sbjct: 612 KEDEHSSTSDYSLIC-----------WHHICSVLTTSGHLRELQVQDSTLSESTFVTWCN 660

Query: 831 TLRRPRCLLETLRLAGCGLTAE------------DCKDLAFGLRA--------------- 863
            LR P C L+ L +     + +            D K L+F L                 
Sbjct: 661 QLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNY 720

Query: 864 -----------------------------NQTLTELDLSFNVLTDAGAKHLCQRLRQPSC 894
                                        N+ LT L++S N L D G   LC+ L  P  
Sbjct: 721 PAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDT 779

Query: 895 KLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
            L  L L  C L+  CC+ ++ +L  + S++ LDL  N L D G++ LCE L+HP C L
Sbjct: 780 VLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCL 838



 Score =  140 bits (353), Expect = 9e-33
 Identities = 76/177 (42%), Positives = 106/177 (59%), Gaps = 2/177 (1%)

Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
           + +  +L   ++++ LDLS N L    +K+LC+ L+ P C L++L L  C +TA  C+DL
Sbjct: 797 EYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDL 856

Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
           A  L +NQ L  L +  N + D G + LC+ L    C+L+ L L  CGLTS CC+DLASV
Sbjct: 857 ASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916

Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--KPSVMTPTEGLDTGE 972
           L+ S +L++L+L  N LD  GV +LCE LRHP C L  LG  K      T+ L T E
Sbjct: 917 LTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAE 973



 Score =  110 bits (274), Expect = 1e-23
 Identities = 65/160 (40%), Positives = 94/160 (58%), Gaps = 1/160 (0%)

Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
           ++L  +L   + L  L++S N L  + V  LC+ L  P  +L  L LA C L+ + C+ +
Sbjct: 741 EVLAGLLTNNKKLTYLNVSCNQLD-TGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYI 799

Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
           +  L  N+++  LDLS NVL D G K LC+ L+ P C L  L LV C +T+  C+DLAS 
Sbjct: 800 SEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASA 859

Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
           L ++ +LK L +  N + DVGV+LLC  L H  C+L  LG
Sbjct: 860 LISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILG 899



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 46/110 (41%), Positives = 60/110 (54%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A  + L S L   +NLK L +  N +    V+ LC+ L    C LE L L  CGLT+
Sbjct: 848 ITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTS 907

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
             CKDLA  L  ++TL +L+L+ N L   G   LC+ LR P C LQ L L
Sbjct: 908 TCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGL 957



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 27/89 (30%), Positives = 48/89 (53%), Gaps = 1/89 (1%)

Query: 9  LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
          L  YLE LKKEE ++F+  L               + +K S  E+A+ L+  Y EQ+AW+
Sbjct: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70

Query: 69 LALHTWEQMGLRSLCAQA-QEGAGHSPSF 96
          + L  +++M  + LC +  +E  G++ ++
Sbjct: 71 ITLRIFQKMDRKDLCMKVMRERTGYTKTY 99



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 26/72 (36%), Positives = 36/72 (50%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L SVL  ++ L++L+L+ N+L H+ V  LC+ LR P C L+ L L       E    L  
Sbjct: 913 LASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTA 972

Query: 860 GLRANQTLTELD 871
               N  LT  D
Sbjct: 973 EEERNPNLTITD 984



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 40/146 (27%), Positives = 68/146 (46%), Gaps = 14/146 (9%)

Query: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDL----SFNVL 877
           H  +KSL +    P+  +++L +  C     + +D AF  +A   L E +     + +++
Sbjct: 532 HQCLKSLGER-GNPQGQVDSLAIFYCLF---EMQDPAFVKQAVNLLQEANFHIIDNVDLV 587

Query: 878 TDAGAKHLCQRLRQPSCKLQRL--QLVSCGLTSD----CCQDLASVLSASPSLKELDLQQ 931
             A     C  LR+    +Q +  +      TSD    C   + SVL+ S  L+EL +Q 
Sbjct: 588 VSAYCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQD 647

Query: 932 NNLDDVGVRLLCEGLRHPACKLIRLG 957
           + L +      C  LRHP+C+L +LG
Sbjct: 648 STLSESTFVTWCNQLRHPSCRLQKLG 673


>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
          Length = 1200

 Score =  322 bits (824), Expect = 2e-87
 Identities = 209/657 (31%), Positives = 339/657 (51%), Gaps = 34/657 (5%)

Query: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGK 386
           PR V+L G +GIGKS LAR++   W +G LY   F +VF+   RE+ + K  S+ E I +
Sbjct: 279 PRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISR 338

Query: 387 DGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGK 446
           +   + AP+ +I+SRPERLLFI+DG D+ G VL    ++LC  W++ QP   L+ SLL K
Sbjct: 339 EWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNN-DTKLCKDWAEKQPPFTLIRSLLRK 397

Query: 447 TILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRL 506
            +LPE+  ++T R    + L   +   R++ V G S   R          E Q  +  R 
Sbjct: 398 VLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRA 457

Query: 507 VKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGP 566
           + +N+EL   C VP V  L C  L  Q    E +   ++T T L   ++   L  + +  
Sbjct: 458 IMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVR 517

Query: 567 Q---------LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI-LQEHPIP 616
           +         L+  C +A EG+W +K++F  DDL   GL  + +     M I L +    
Sbjct: 518 RCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCE 577

Query: 617 LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKT-----LEAYGIHGLFGASTT 671
             Y+F HL  Q+F AA+ YVLE  +   + + C + +EKT     L+  G H +      
Sbjct: 578 EYYTFFHLSLQDFCAALYYVLEGLE--IEPALCPLYVEKTKRSMELKQAGFH-IHSLWMK 634

Query: 672 RFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPH------SLESLHCLY 723
           RFL GL+S++  R +E +  C +  G  + L+ WV  L    QP+      +L++ HCL+
Sbjct: 635 RFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLG--QQPNATTPGDTLDAFHCLF 692

Query: 724 ETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL----IEGRQHRSTW 779
           ET++K F+   +  F+E+ + +  +++L+  +FC++   +++K+++    I  R   +  
Sbjct: 693 ETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEA 752

Query: 780 SPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLL 839
            P + +  R   + +  W+   S+L    +L++LDL  + L+  A+K+LC  LR P C +
Sbjct: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812

Query: 840 ETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRL 899
           +TL      +T    + L   + AN+ L  L+L    L +   +  C+ L+ P C L+ L
Sbjct: 813 QTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871

Query: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
           +L  CGLT  C   ++ +L+ SPSLK L L  N + D GV  L + LR   C L +L
Sbjct: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKL 928



 Score =  137 bits (344), Expect = 9e-32
 Identities = 77/166 (46%), Positives = 94/166 (56%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T    Q L S L   R+L  L LS NSL +  V  LC+++R P C L+ L L  C L  
Sbjct: 935  ITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDT 994

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C  LA  L  N  LT L LS N + D G K LC+ +R+PSC LQ L+LV C LT+ CC
Sbjct: 995  AGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACC 1054

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
            + L+ V+S S  LK LDL  N L D GV  LCEGL+     L RLG
Sbjct: 1055 ESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLG 1100



 Score =  115 bits (288), Expect = 3e-25
 Identities = 65/162 (40%), Positives = 91/162 (56%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T A +  +  +L  + +LK L L+GN ++   V  L   LR  +C L+ L L  CG+TA
Sbjct: 878  LTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITA 937

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C+ LA  L +N++LT L LS N L + G   LC+ +R P C LQRL L  C L +  C
Sbjct: 938  TGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGC 997

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
              LA  L  +  L  L L  N ++D GV+LLCE +R P+C L
Sbjct: 998  GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHL 1039



 Score =  108 bits (271), Expect = 3e-23
 Identities = 60/148 (40%), Positives = 81/148 (54%)

Query: 810  LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
            L  L LS N +  + VK LC+ +R P C L+ L L  C LTA  C+ L+  +  ++ L  
Sbjct: 1010 LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKS 1069

Query: 870  LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
            LDL+ N L D G   LC+ L+Q +  L RL L +CGLTSDCC+ L+  LS +  L  L+L
Sbjct: 1070 LDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNL 1129

Query: 930  QQNNLDDVGVRLLCEGLRHPACKLIRLG 957
             QNN    G+  LC     P   L  +G
Sbjct: 1130 VQNNFSPKGMMKLCSAFACPTSNLQIIG 1157



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 39/110 (35%), Positives = 60/110 (54%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T A  + L  V+  +R+LK LDL+ N+L    V +LC+ L++   +L  L L  CGLT+
Sbjct: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
            + C+ L+  L  N+ LT L+L  N  +  G   LC     P+  LQ + L
Sbjct: 1109 DCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158



 Score = 39.3 bits (90), Expect = 0.027
 Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 4/95 (4%)

Query: 5   AWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ-YGE 63
           ++G   C  E L KEE + F+ LL  K+ S S++   P    + + +E  + L+ + YG 
Sbjct: 62  SYGLQWCLYE-LDKEEFQTFKELLKKKS-SESTTCSIPQFEIENANVECLALLLHEYYGA 119

Query: 64  QRAWDLALHTWEQMGLRSLCAQAQEG-AGHSPSFP 97
             AW  ++  +E M LR+L  +A++    HSP  P
Sbjct: 120 SLAWATSISIFENMNLRTLSEKARDDMKRHSPEDP 154


>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
           isoform 3 [Homo sapiens]
          Length = 1037

 Score =  316 bits (809), Expect = 1e-85
 Identities = 244/729 (33%), Positives = 357/729 (48%), Gaps = 101/729 (13%)

Query: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
           F P L+ + PR      V+L G AG+GK+TLA++    W    L     ++ FY SC+EL
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215

Query: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
           ++    S AELI KD       I  IL++ +R+LF++DG+DE    PG ++Q+    +C 
Sbjct: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271

Query: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
            W + +P   LLGSLL + +LP A+ L+T R  AL++L    +Q  +V V GF E  R+ 
Sbjct: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331

Query: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
           YF R+F DE QA+RAF L++SN  L+ L   P V W+ CT L  QM++ E    T  T T
Sbjct: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391

Query: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
            L L +L     Q   L   LR L  LAA+G+W + ++F  +DL + G+  + +  FL  
Sbjct: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451

Query: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
            IL++  +    YSFIHL FQ+F  A+ Y LE E+G  R  H+  I D++K L   G   
Sbjct: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509

Query: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQL---LLQPHSL 716
           L      +   FL GL +++  +E+E  F CR+S    + L+Q    L     L      
Sbjct: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK 569

Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------- 769
           E L CLYE++ +     V+A F+E+ + +    E++ C+F +K  + ++KL L       
Sbjct: 570 EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF 629

Query: 770 --------IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLS 821
                   ++    R T+  T+    R    +   W    S+     NLK L++  + LS
Sbjct: 630 LENYMDFELDIEFERCTYL-TIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLS 688

Query: 822 HSAVKSLCKTLRRPRCLLET---------------------------LRLAG-------- 846
            S+V+ LC  + R  C L+                            L LAG        
Sbjct: 689 DSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTM 748

Query: 847 ------------CGL----------TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKH 884
                       C L          T E   +  + L+ANQ+L  L LS NVL D GA  
Sbjct: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808

Query: 885 LCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
           L + + +P   LQ L L +C LT   C+DLA+VL  S  L  L L +N + D GV+ LCE
Sbjct: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868

Query: 945 GLRHPACKL 953
           GL +P CKL
Sbjct: 869 GLSYPDCKL 877



 Score =  113 bits (282), Expect = 1e-24
 Identities = 70/172 (40%), Positives = 91/172 (52%), Gaps = 3/172 (1%)

Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
           T   W   F VLK  ++LK L LS N L       L KT+ RP+  L+ L L  C LT  
Sbjct: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833

Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
            CKDLA  L  ++ LT L L+ N + D G K LC+ L  P CKLQ L L  C +T   C+
Sbjct: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893

Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL--IRLGKPSVM 962
            L+  L  + SL  LDL  N +   G+ +LC+ L +P C L  +RL   S+M
Sbjct: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLM 944



 Score = 97.8 bits (242), Expect = 6e-20
 Identities = 65/167 (38%), Positives = 93/167 (55%), Gaps = 3/167 (1%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + L +VL V++ L  L L+ N +  + VK LC+ L  P C L+TL L  C +T 
Sbjct: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C+ L+  L+   +LT LDLS N +   G   LCQ L  P+C L+ L+L SC L    C
Sbjct: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 948

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRL 956
           Q L S L ++  L+ LDL QN+L   G+  L   LR    + K++RL
Sbjct: 949 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 995



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 48/156 (30%), Positives = 71/156 (45%), Gaps = 3/156 (1%)

Query: 769  LIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSL 828
            L EG  +      T+V+  +   +T    + L   L+   +L  LDLS N ++   +  L
Sbjct: 866  LCEGLSYPDCKLQTLVL--QQCSITKLGCRYLSEALQEACSLTNLDLSINQIARG-LWIL 922

Query: 829  CKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQR 888
            C+ L  P C L+ LRL  C L    C+ L   L +NQ L  LDL  N L  +G   L   
Sbjct: 923  CQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGV 982

Query: 889  LRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSL 924
            LRQ +  L+ L+L +     +  + L  V   +P L
Sbjct: 983  LRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKL 1018


>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
           2 [Homo sapiens]
          Length = 980

 Score =  316 bits (809), Expect = 1e-85
 Identities = 244/729 (33%), Positives = 357/729 (48%), Gaps = 101/729 (13%)

Query: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
           F P L+ + PR      V+L G AG+GK+TLA++    W    L     ++ FY SC+EL
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215

Query: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
           ++    S AELI KD       I  IL++ +R+LF++DG+DE    PG ++Q+    +C 
Sbjct: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271

Query: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
            W + +P   LLGSLL + +LP A+ L+T R  AL++L    +Q  +V V GF E  R+ 
Sbjct: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331

Query: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
           YF R+F DE QA+RAF L++SN  L+ L   P V W+ CT L  QM++ E    T  T T
Sbjct: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391

Query: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
            L L +L     Q   L   LR L  LAA+G+W + ++F  +DL + G+  + +  FL  
Sbjct: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451

Query: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
            IL++  +    YSFIHL FQ+F  A+ Y LE E+G  R  H+  I D++K L   G   
Sbjct: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509

Query: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQL---LLQPHSL 716
           L      +   FL GL +++  +E+E  F CR+S    + L+Q    L     L      
Sbjct: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK 569

Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------- 769
           E L CLYE++ +     V+A F+E+ + +    E++ C+F +K  + ++KL L       
Sbjct: 570 EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF 629

Query: 770 --------IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLS 821
                   ++    R T+  T+    R    +   W    S+     NLK L++  + LS
Sbjct: 630 LENYMDFELDIEFERCTYL-TIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLS 688

Query: 822 HSAVKSLCKTLRRPRCLLET---------------------------LRLAG-------- 846
            S+V+ LC  + R  C L+                            L LAG        
Sbjct: 689 DSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTM 748

Query: 847 ------------CGL----------TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKH 884
                       C L          T E   +  + L+ANQ+L  L LS NVL D GA  
Sbjct: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808

Query: 885 LCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
           L + + +P   LQ L L +C LT   C+DLA+VL  S  L  L L +N + D GV+ LCE
Sbjct: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868

Query: 945 GLRHPACKL 953
           GL +P CKL
Sbjct: 869 GLSYPDCKL 877



 Score =  112 bits (280), Expect = 2e-24
 Identities = 67/164 (40%), Positives = 86/164 (52%), Gaps = 1/164 (0%)

Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
           T   W   F VLK  ++LK L LS N L       L KT+ RP+  L+ L L  C LT  
Sbjct: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833

Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
            CKDLA  L  ++ LT L L+ N + D G K LC+ L  P CKLQ L L  C +T   C+
Sbjct: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893

Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
            L+  L  + SL  LDL  N +   G+ +LC+ L +P C L  L
Sbjct: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHL 936



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 47/133 (35%), Positives = 71/133 (53%), Gaps = 1/133 (0%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + L +VL V++ L  L L+ N +  + VK LC+ L  P C L+TL L  C +T 
Sbjct: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C+ L+  L+   +LT LDLS N +   G   LCQ L  P+C L+ L+L +     +  
Sbjct: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIK 948

Query: 912 QDLASVLSASPSL 924
           + L  V   +P L
Sbjct: 949 KLLEEVKEKNPKL 961


>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
          Length = 892

 Score =  296 bits (759), Expect = 7e-80
 Identities = 240/745 (32%), Positives = 355/745 (47%), Gaps = 83/745 (11%)

Query: 276 QKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGA 335
           ++FT+LL+        ++ L     P+     R        LF    + + P  V+LQG 
Sbjct: 145 KRFTKLLIAPES-AAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVVLQGP 203

Query: 336 AGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVV-SLAELIGKDGTATPAP 394
           AGIGK+  A+++   W  G+LY  +    F+  C EL +     SLA+LI        AP
Sbjct: 204 AGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAP 263

Query: 395 IRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASF 454
           + Q+L++P+RLLFILDG DE    L  P +  C    +      +LG LL K +LP A  
Sbjct: 264 VPQMLAQPQRLLFILDGADELP-ALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALL 322

Query: 455 LITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELW 514
           L+T R  A   L   L   +  EV GFS+  +K+YFY++F DER+A RA+R VK N+ L+
Sbjct: 323 LVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLF 382

Query: 515 ALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPL--GPQL---- 568
           ALC VP+V W+ CT L QQ++    L+ TSKTTT++ L ++   L + P+  GP+L    
Sbjct: 383 ALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDL 442

Query: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST-FLKM----GILQEHPIPLSYSFIH 623
           R+LC LA EG+  ++  F+  +L +  L G+ + T FL      G+L+     ++Y FI 
Sbjct: 443 RNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETE---VTYQFID 499

Query: 624 LCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE 683
             FQEF AA+SY+LED       +  +  L +       H +    TTRFL GLLS E  
Sbjct: 500 QSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHLVL---TTRFLFGLLSAERM 556

Query: 684 REMENIFHCRLSQ--GRNLMQWV------------------PSLQLLLQP---------- 713
           R++E  F C +S+   +  ++WV                    L+   +P          
Sbjct: 557 RDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPN 616

Query: 714 HSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKKLQLIE 771
           + LE L+CLYET+   F+ Q +  F E+ +       M++ V ++C++     + L+LI 
Sbjct: 617 YPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLIS 676

Query: 772 GRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
                           R V   +   + L   L+ +       L G S S    K L  +
Sbjct: 677 ---------------CRLVAAQEKKKKSLGKRLQAS-------LGGGSSSQGTTKQLPAS 714

Query: 832 LRR--------PRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
           L          P C L +L L+ C L    C+DL+  LRA   LTEL L  N L++AG +
Sbjct: 715 LLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLR 774

Query: 884 HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLC 943
            L + L  P C++Q ++ V         Q L  +L  SP+L  LDL    L    V  LC
Sbjct: 775 MLSEGLAWPQCRVQTVR-VQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLC 833

Query: 944 EGLRHPACKLIRLGKPSVMTPTEGL 968
             L+H  C L  L   SV    + L
Sbjct: 834 AVLQHQGCGLQTLSLASVELSEQSL 858


>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
          Length = 1048

 Score =  281 bits (719), Expect = 3e-75
 Identities = 199/667 (29%), Positives = 327/667 (49%), Gaps = 48/667 (7%)

Query: 325 QEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELI 384
           ++P+ V +QGA GIGK+ LA++V   W R + Y  +    FYF C+E+ Q+   S +ELI
Sbjct: 201 RQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELI 260

Query: 385 GKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLL 444
            +    +   + +I+S+P++LL +LDG +E    L +   +L   W Q  P   LL SLL
Sbjct: 261 EQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLL 320

Query: 445 GKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF 504
            KT+LPEA+ LI  R T+ Q   P L+    V + GF+   + +YF  YF    +  +  
Sbjct: 321 SKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVL 380

Query: 505 RLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYL-------AQ 557
                N  L+++C VP V W+ C+ L QQM+R   LT +    T++ + Y+       A+
Sbjct: 381 SFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAE 440

Query: 558 ALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL------Q 611
               +    QL  LC LAA+ +W +K +   +DL +  LD   ++ FL M IL      +
Sbjct: 441 NFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEE 500

Query: 612 EHPIPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGAST 670
           +H     Y F  + FQEFFAA+ YVL   ++ +  H    +++++ + +      + +  
Sbjct: 501 DH-----YVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHM 555

Query: 671 TRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHS----LESLHCLYE 724
             FL G L++     +E  F C++S G  R L++ +P L     P       +  +CL+E
Sbjct: 556 GLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHE 615

Query: 725 TRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL-----------IEGR 773
            R + F++Q +  + ++ + +  + E+ V  FC+K  +++ +++L           +   
Sbjct: 616 IREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSS 675

Query: 774 QHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLR 833
            H  + +P    L RW       WQ L SV      L+ L ++ + L    +K+L   LR
Sbjct: 676 SHPGSEAPESNGLHRW-------WQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALR 728

Query: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
            P+C L+ L L     T  + +DL   L  NQ L  L++    +     K LC+ LR P 
Sbjct: 729 HPQCKLQKLLLRRVNSTMLN-QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPR 787

Query: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLL----CEGLRHP 949
           C+LQ L+L  C  T     DL + L  +  LK L L++N+L++ G   L     E L   
Sbjct: 788 CRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQLERLSIE 847

Query: 950 ACKLIRL 956
            C L +L
Sbjct: 848 NCNLTQL 854



 Score =  110 bits (275), Expect = 9e-24
 Identities = 73/207 (35%), Positives = 93/207 (44%), Gaps = 51/207 (24%)

Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLA------------ 845
           Q L  VL   ++L+ L++    +   AVK LC+ LR PRC L+ LRL             
Sbjct: 749 QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808

Query: 846 ---------------------------------------GCGLTAEDCKDLAFGLRANQT 866
                                                   C LT   C+ LA  LR ++ 
Sbjct: 809 GNNLQGNGHLKTLILRKNSLENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKM 868

Query: 867 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE 926
           LT L L+ N L D GAKH+   L    C LQRL L  C LT +CCQD+ S L  + +LK 
Sbjct: 869 LTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKS 928

Query: 927 LDLQQNNLDDVGVRLLCEGLRHPACKL 953
           LDL  N+L D GV LLCE L++P C L
Sbjct: 929 LDLSFNSLKDDGVILLCEALKNPDCTL 955



 Score =  108 bits (269), Expect = 5e-23
 Identities = 61/153 (39%), Positives = 84/153 (54%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T    + L S L+ ++ L  L L+ N+L     K +   L   RC L+ L L  C LT 
Sbjct: 851  LTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTF 910

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C+D+   L  N+TL  LDLSFN L D G   LC+ L+ P C LQ L+L +C  TS CC
Sbjct: 911  NCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICC 970

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
            Q +AS+L  +  L+ LDL +N +   G+  LCE
Sbjct: 971  QAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 62/211 (29%), Positives = 95/211 (45%), Gaps = 29/211 (13%)

Query: 709  LLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKK 766
            L+L+ +SLE+    Y +         +A  E + +  C  T +       C++ S+ +  
Sbjct: 821  LILRKNSLENCGAYYLS---------VAQLERLSIENCNLTQLTCESLASCLRQSKMLTH 871

Query: 767  LQLIE------GRQHRSTWS-------PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKEL 813
            L L E      G +H   W+       P   ++ R   +T    Q + S L   + LK L
Sbjct: 872  LSLAENALKDEGAKH--IWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSL 929

Query: 814  DLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLS 873
            DLS NSL    V  LC+ L+ P C L+ L L  C  T+  C+ +A  LR NQ L  LDLS
Sbjct: 930  DLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLS 989

Query: 874  FNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
             N +   G   LC+     S + +R +++ C
Sbjct: 990  KNAIGVYGILTLCEAF---SSQKKREEVIFC 1017



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 7/75 (9%)

Query: 12  YLEFLKKEELKEFQLLLANKAHSRSSSGETPA---QPEKTSGMEVASYLVAQYGEQRAWD 68
           Y+  +  EEL+ F+ LL  +     S+G  P    Q E  S  EV   L+ ++  +RAWD
Sbjct: 44  YMRNVSHEELQRFKQLLLTEL----STGTMPITWDQVETASWAEVVHLLIERFPGRRAWD 99

Query: 69  LALHTWEQMGLRSLC 83
           +  + +  M    +C
Sbjct: 100 VTSNIFAIMNCDKMC 114


>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
          Length = 655

 Score =  252 bits (643), Expect = 2e-66
 Identities = 176/493 (35%), Positives = 261/493 (52%), Gaps = 26/493 (5%)

Query: 253 HPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLI 312
           H +    RE +     W+    N ++ Q+LL+ +P   S + L    +P+   E+    +
Sbjct: 96  HDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSESPESLAC-PFPEQELES----V 150

Query: 313 EIRDLFGPG-LDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRE 371
            +  LF  G   +  P +V+LQG+AG GK+TLAR++   W  G LY  RF +VFY SC+E
Sbjct: 151 TVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKE 210

Query: 372 LAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWS 431
           +       L +L+        AP+ +IL +PERLLFILDG DE    LQ P  E  L   
Sbjct: 211 VVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDE----LQRPFEEK-LKKR 265

Query: 432 QPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFY 491
              P ++LL  L+ +  LP  S LIT R  AL+NL P L+QAR V +LGFSE  R  YF 
Sbjct: 266 GLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFS 325

Query: 492 RYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLC 551
            YFTDE+QA RAF +V+ N  L+  C VP + W+ C+ L  QM+R + +  T + +T + 
Sbjct: 326 SYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIF 385

Query: 552 LHYLAQALQAQPLG--------PQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST 603
           + Y++  L     G          LR LCSLAAEGI  ++ LF   +LRKH LDG  ++ 
Sbjct: 386 MAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAA 445

Query: 604 FLKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGR-GKHSNCIIDLEKTLEAYG 661
           FL     Q    I   YSF H+ FQ+FF AMSY++++++ R GK S    ++++ LE   
Sbjct: 446 FLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESR--REVQRLLEVKE 503

Query: 662 IHGLFGAS-TTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPHSLES 718
             G    + T +FLL +   +    +E  F  R+S    ++L  +   ++ +    + + 
Sbjct: 504 QEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDL 563

Query: 719 LHCLYETRNKTFL 731
              LYE + K  +
Sbjct: 564 EFSLYEAKIKNLV 576


>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
          Length = 1033

 Score =  250 bits (638), Expect = 8e-66
 Identities = 191/650 (29%), Positives = 309/650 (47%), Gaps = 41/650 (6%)

Query: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
           V L G    GK+ +       W +G+++ +   +V + +  E+ Q    SLAELI KD  
Sbjct: 149 VFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWP 208

Query: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
              API  ILS P++LLFIL+ +D   + L    S LC + +Q  P   LL SLL + + 
Sbjct: 209 DGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMA 268

Query: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
           P   FLI++R T   N+   L++      L  S   R+ YF  +F D ++A  A +LV  
Sbjct: 269 PGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHE 328

Query: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQP------ 563
           ++ L  LC V  + W+ CT L +QM +     L  +T T L  H+LA AL ++       
Sbjct: 329 DEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQ 388

Query: 564 --LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL-QEHPIPLSYS 620
             LG  L+ LC LAA G++     FS +DLR  G   A +S      IL   +     Y 
Sbjct: 389 YHLG-LLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYK 447

Query: 621 FIHLCFQEFFAAMSYVLEDEK-----GRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLL 675
           FIHL  QEF  A+++++         G  ++       EK  +    + +F      F+ 
Sbjct: 448 FIHLNVQEFCTAIAFLMAVPNYLIPSGSREYK------EKREQYSDFNQVF-----TFIF 496

Query: 676 GLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQ------PHSLESLHCLYETRNKT 729
           GLL+    + +E  F  +L    +   +       L        H +   +CLYE R + 
Sbjct: 497 GLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEE 556

Query: 730 FLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGR---QHRSTWSPTMVVL 786
           F+  ++    E+ + +++D +++V  +C+ +  H++ L+L   R          PT   +
Sbjct: 557 FVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQM 616

Query: 787 FRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAG 846
              V     YW+ + S+     +L+EL +  N L+  + + L K L    C L TL+L+ 
Sbjct: 617 KSLV-----YWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSY 671

Query: 847 CGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGL 906
              TA   +DL   L  N++LT L ++   ++      L   L +P+C++  L L+ C L
Sbjct: 672 VS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDL 730

Query: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
            +  C+++AS+L +  SL++L L  N L   G+ +LC+ L HP C LI L
Sbjct: 731 RASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISL 780



 Score =  111 bits (278), Expect = 4e-24
 Identities = 59/154 (38%), Positives = 85/154 (55%)

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
           +L++L LS N L    +  LC  L  P C L +L L  C LT   C  L   L  + TL 
Sbjct: 747 SLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLR 806

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
           +LDL  N L + G  H+   L  P+C+L+ L L  C  +SD CQ +A V++ +  L+ L+
Sbjct: 807 QLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLE 866

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVM 962
           +  N ++D G++LLC GLRHP C L+ +G    M
Sbjct: 867 IGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECM 900



 Score =  109 bits (273), Expect = 2e-23
 Identities = 64/168 (38%), Positives = 94/168 (55%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+     L  VL  +  L++LDL  N L +  V  +   L  P C LE L L+GC  ++
Sbjct: 787 LTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSS 846

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
           + C+ +A  +  N+ L  L++  N + DAG + LC  LR P+C L  + L  C LTS CC
Sbjct: 847 DICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACC 906

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKP 959
           + LASVL+ + +L+ L+L QN+L + GV  L E L  P C L  +G P
Sbjct: 907 RSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLP 954



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 42/127 (33%), Positives = 63/127 (49%)

Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
           Q +  V+     L+ L++  N +  + ++ LC  LR P C+L  + L  C LT+  C+ L
Sbjct: 850 QYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSL 909

Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
           A  L  N+TL  L+L  N L + G   L + L  P C L+ + L   GL +   Q L +V
Sbjct: 910 ASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTV 969

Query: 918 LSASPSL 924
               PSL
Sbjct: 970 KERKPSL 976



 Score = 34.7 bits (78), Expect = 0.66
 Identities = 18/58 (31%), Positives = 33/58 (56%), Gaps = 1/58 (1%)

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLD 969
           +++ S+     SL+EL +  N+L+ +  R+L + L H +CKL R  K S ++   G +
Sbjct: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKL-RTLKLSYVSTASGFE 679



 Score = 34.3 bits (77), Expect = 0.86
 Identities = 20/61 (32%), Positives = 32/61 (52%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A  + L SVL   + L+ L+L  N L +  V  L ++L  P C+L+ + L   GL  
Sbjct: 901 LTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNT 960

Query: 852 E 852
           +
Sbjct: 961 Q 961


>gi|7662404 caspase recruitment domain family, member 8 [Homo sapiens]
          Length = 431

 Score =  248 bits (633), Expect = 3e-65
 Identities = 151/382 (39%), Positives = 204/382 (53%), Gaps = 56/382 (14%)

Query: 1049 FWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLG- 1107
            F GP G V  E++DK  N Y V FP AG Y W  TGL F++R+ VTV I F  W Q L  
Sbjct: 56   FLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLAL 115

Query: 1108 EINPQHSWMVAGPLLDIKAEPG-AVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1166
            ++     W+V GPL D+ AEP  AV  +HLPHF++LQG  VD S F +AHFK EGM+LE 
Sbjct: 116  DLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQG-EVDVSWFLVAHFKNEGMVLEH 174

Query: 1167 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1226
            PARVE  + VLE+PSFS +G+LL++       IP+TS  L+Y+  HPE++ FHLYL+PSD
Sbjct: 175  PARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSD 234

Query: 1227 CSIRK------------------------------------------ELELCYRSPGEDQ 1244
              + K                                          EL+L YRSPGE Q
Sbjct: 235  ALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQ 294

Query: 1245 LFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQL 1304
             FS+FY G +   I+L++ +K+  TLVW+  VKP DL       PP       P      
Sbjct: 295  HFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPP-------PFSGAA- 346

Query: 1305 LHFVDQYREQLIARVTSVEVVLDKLH-GQVLSQEQYERVLAENTRPSQMRKLFSLSQSWD 1363
              FV +   QL AR+  ++ VLD L   +VL++ + E V  E TR S+   L S+ +   
Sbjct: 347  --FVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKG 404

Query: 1364 RKCKDGLYQALKETHPHLIMEL 1385
                D L++++ E  P+L+  L
Sbjct: 405  DLALDVLFRSISERDPYLVSYL 426


>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
           sapiens]
          Length = 287

 Score =  144 bits (364), Expect = 5e-34
 Identities = 79/156 (50%), Positives = 98/156 (62%)

Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
           Q + SVL    +L ELDL+GN+L    ++ LC+ LR P C L TL L  C LTA  C +L
Sbjct: 100 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159

Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
           A  L  NQ+L ELDLS N L D G   LC+ LR P+CKLQ L+L SCGLT+  C++L   
Sbjct: 160 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219

Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           L  + +L +L L  N L D GVRLLC+ L HP CKL
Sbjct: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKL 255



 Score =  144 bits (363), Expect = 6e-34
 Identities = 74/154 (48%), Positives = 97/154 (62%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L + L   +NL  +DLSGN +    +  LC+ LR P+C L+ ++L  C L +  C+++A 
Sbjct: 45  LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 104

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            L  N  L ELDL+ N L D G + LCQ LR P C+L+ L L  C LT+  C +LAS LS
Sbjct: 105 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 164

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
            + SL+ELDL  N L D+GV LLCEGLRHP CKL
Sbjct: 165 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198



 Score =  115 bits (287), Expect = 4e-25
 Identities = 61/135 (45%), Positives = 86/135 (63%), Gaps = 2/135 (1%)

Query: 819 SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLT 878
           S+S +  ++    L +PR   + L L  C +++  C+DL+  L AN+ LT +DLS N + 
Sbjct: 9   SVSPATQEAKAGGLLQPR--RQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVG 66

Query: 879 DAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVG 938
             G   LC+ LR P C+LQ +QL  C L S  CQ++ASVL  +P L ELDL  N L+D+G
Sbjct: 67  FPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLG 126

Query: 939 VRLLCEGLRHPACKL 953
           +RLLC+GLRHP C+L
Sbjct: 127 LRLLCQGLRHPVCRL 141



 Score =  103 bits (257), Expect = 1e-21
 Identities = 61/133 (45%), Positives = 77/133 (57%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A    L S L V ++L+ELDLS N L    V  LC+ LR P C L+TLRL  CGLTA
Sbjct: 151 LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTA 210

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
           + C++L F L  NQTLT+L L+ N L D G + LC+RL  P CKL+ L L    L     
Sbjct: 211 KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTH 270

Query: 912 QDLASVLSASPSL 924
             LA++    P L
Sbjct: 271 SRLAALRVTKPYL 283


>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  130 bits (328), Expect = 7e-30
 Identities = 70/162 (43%), Positives = 100/162 (61%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A   +L S L+    L+EL LS N L  + ++ LC+ L  P+C LE L+L  C L+A
Sbjct: 97  LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C+ LA  LRA     EL +S N + +AG + LCQ L+   C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           +DL  ++++  SL+EL L  N L DVG+  LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258



 Score =  129 bits (323), Expect = 3e-29
 Identities = 77/199 (38%), Positives = 112/199 (56%), Gaps = 1/199 (0%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + + S L+V   L EL+L  N L    V  + + L+ P C ++ L L  C LT 
Sbjct: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C  L+  LR   TL EL LS N+L DAG + LC+ L  P C+L++LQL  C L++  C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDT 970
           + LASVL A P  KEL +  N++++ GVR+LC+GL+   C+L  L   S  +T     D 
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 971 GEMSNSTSSLKRQRLGSER 989
             +  S +SL+   LGS +
Sbjct: 220 CGIVASKASLRELALGSNK 238



 Score =  126 bits (316), Expect = 2e-28
 Identities = 67/154 (43%), Positives = 91/154 (59%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L SVL+   + KEL +S N ++ + V+ LC+ L+   C LE L+L  CG+T+++C+DL  
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            + +  +L EL L  N L D G   LC  L  PS +L+ L +  CG+T+  C DL  VL 
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           A  SLKEL L  N L D G RLLCE L  P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315



 Score =  121 bits (304), Expect = 4e-27
 Identities = 67/157 (42%), Positives = 87/157 (55%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L  VL+   +LKEL L+GN L     + LC+TL  P C LE+L +  C  TA  C   + 
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            L  N+ L EL +S N L DAG + LCQ L QP   L+ L L  C ++   C  LA+ L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
           A+ SL+ELDL  N L D G+  L E +R P C L +L
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQL 432



 Score =  119 bits (297), Expect = 3e-26
 Identities = 78/214 (36%), Positives = 110/214 (51%), Gaps = 18/214 (8%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            VT    + L  ++    +L+EL L  N L    +  LC  L  P   L TL +  CG+TA
Sbjct: 211  VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
            + C DL   LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC  T+ CC
Sbjct: 271  KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971
               +SVL+ +  L EL +  N L+D GVR LC+GL  P          SV+      D  
Sbjct: 331  SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG---------SVLRVLWLADCD 381

Query: 972  EMSNSTSSLKRQRLGSERAASHVAQANLKLLDVS 1005
               +S SSL         AA+ +A  +L+ LD+S
Sbjct: 382  VSDSSCSSL---------AATLLANHSLRELDLS 406



 Score =  108 bits (270), Expect = 4e-23
 Identities = 61/148 (41%), Positives = 85/148 (57%), Gaps = 4/148 (2%)

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
           +++ LD+    LS +    L   L++     + +RL  CGLT   CKD++  LR N  L 
Sbjct: 4   DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
           EL+L  N L D G   + Q L+ PSCK+Q+L L +C LT   C  L+S L   P+L+EL 
Sbjct: 60  ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRL 956
           L  N L D G++LLCEGL  P C+L +L
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKL 147



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 49/124 (39%), Positives = 67/124 (54%)

Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
           SVL   R L EL +S N L  + V+ LC+ L +P  +L  L LA C ++   C  LA  L
Sbjct: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394

Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
            AN +L ELDLS N L DAG   L + +RQP C L++L L     + +    L ++    
Sbjct: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDK 454

Query: 922 PSLK 925
           PSL+
Sbjct: 455 PSLR 458



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)

Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
           P  V+   W+    V+D+    L + L    +L+ELDLS N L  + +  L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 838 LLETLRL 844
           LLE L L
Sbjct: 428 LLEQLVL 434


>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  130 bits (328), Expect = 7e-30
 Identities = 70/162 (43%), Positives = 100/162 (61%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A   +L S L+    L+EL LS N L  + ++ LC+ L  P+C LE L+L  C L+A
Sbjct: 97  LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C+ LA  LRA     EL +S N + +AG + LCQ L+   C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           +DL  ++++  SL+EL L  N L DVG+  LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258



 Score =  129 bits (323), Expect = 3e-29
 Identities = 77/199 (38%), Positives = 112/199 (56%), Gaps = 1/199 (0%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + + S L+V   L EL+L  N L    V  + + L+ P C ++ L L  C LT 
Sbjct: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C  L+  LR   TL EL LS N+L DAG + LC+ L  P C+L++LQL  C L++  C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDT 970
           + LASVL A P  KEL +  N++++ GVR+LC+GL+   C+L  L   S  +T     D 
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 971 GEMSNSTSSLKRQRLGSER 989
             +  S +SL+   LGS +
Sbjct: 220 CGIVASKASLRELALGSNK 238



 Score =  126 bits (316), Expect = 2e-28
 Identities = 67/154 (43%), Positives = 91/154 (59%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L SVL+   + KEL +S N ++ + V+ LC+ L+   C LE L+L  CG+T+++C+DL  
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            + +  +L EL L  N L D G   LC  L  PS +L+ L +  CG+T+  C DL  VL 
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           A  SLKEL L  N L D G RLLCE L  P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315



 Score =  121 bits (304), Expect = 4e-27
 Identities = 67/157 (42%), Positives = 87/157 (55%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L  VL+   +LKEL L+GN L     + LC+TL  P C LE+L +  C  TA  C   + 
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            L  N+ L EL +S N L DAG + LCQ L QP   L+ L L  C ++   C  LA+ L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
           A+ SL+ELDL  N L D G+  L E +R P C L +L
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQL 432



 Score =  119 bits (297), Expect = 3e-26
 Identities = 78/214 (36%), Positives = 110/214 (51%), Gaps = 18/214 (8%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            VT    + L  ++    +L+EL L  N L    +  LC  L  P   L TL +  CG+TA
Sbjct: 211  VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
            + C DL   LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC  T+ CC
Sbjct: 271  KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971
               +SVL+ +  L EL +  N L+D GVR LC+GL  P          SV+      D  
Sbjct: 331  SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG---------SVLRVLWLADCD 381

Query: 972  EMSNSTSSLKRQRLGSERAASHVAQANLKLLDVS 1005
               +S SSL         AA+ +A  +L+ LD+S
Sbjct: 382  VSDSSCSSL---------AATLLANHSLRELDLS 406



 Score =  108 bits (270), Expect = 4e-23
 Identities = 61/148 (41%), Positives = 85/148 (57%), Gaps = 4/148 (2%)

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
           +++ LD+    LS +    L   L++     + +RL  CGLT   CKD++  LR N  L 
Sbjct: 4   DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
           EL+L  N L D G   + Q L+ PSCK+Q+L L +C LT   C  L+S L   P+L+EL 
Sbjct: 60  ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRL 956
           L  N L D G++LLCEGL  P C+L +L
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKL 147



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 49/124 (39%), Positives = 67/124 (54%)

Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
           SVL   R L EL +S N L  + V+ LC+ L +P  +L  L LA C ++   C  LA  L
Sbjct: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394

Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
            AN +L ELDLS N L DAG   L + +RQP C L++L L     + +    L ++    
Sbjct: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDK 454

Query: 922 PSLK 925
           PSL+
Sbjct: 455 PSLR 458



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)

Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
           P  V+   W+    V+D+    L + L    +L+ELDLS N L  + +  L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 838 LLETLRL 844
           LLE L L
Sbjct: 428 LLEQLVL 434


>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  130 bits (328), Expect = 7e-30
 Identities = 70/162 (43%), Positives = 100/162 (61%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A   +L S L+    L+EL LS N L  + ++ LC+ L  P+C LE L+L  C L+A
Sbjct: 97  LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C+ LA  LRA     EL +S N + +AG + LCQ L+   C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           +DL  ++++  SL+EL L  N L DVG+  LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258



 Score =  129 bits (323), Expect = 3e-29
 Identities = 77/199 (38%), Positives = 112/199 (56%), Gaps = 1/199 (0%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + + S L+V   L EL+L  N L    V  + + L+ P C ++ L L  C LT 
Sbjct: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C  L+  LR   TL EL LS N+L DAG + LC+ L  P C+L++LQL  C L++  C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDT 970
           + LASVL A P  KEL +  N++++ GVR+LC+GL+   C+L  L   S  +T     D 
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 971 GEMSNSTSSLKRQRLGSER 989
             +  S +SL+   LGS +
Sbjct: 220 CGIVASKASLRELALGSNK 238



 Score =  126 bits (316), Expect = 2e-28
 Identities = 67/154 (43%), Positives = 91/154 (59%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L SVL+   + KEL +S N ++ + V+ LC+ L+   C LE L+L  CG+T+++C+DL  
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            + +  +L EL L  N L D G   LC  L  PS +L+ L +  CG+T+  C DL  VL 
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           A  SLKEL L  N L D G RLLCE L  P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315



 Score =  121 bits (304), Expect = 4e-27
 Identities = 67/157 (42%), Positives = 87/157 (55%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L  VL+   +LKEL L+GN L     + LC+TL  P C LE+L +  C  TA  C   + 
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            L  N+ L EL +S N L DAG + LCQ L QP   L+ L L  C ++   C  LA+ L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
           A+ SL+ELDL  N L D G+  L E +R P C L +L
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQL 432



 Score =  119 bits (297), Expect = 3e-26
 Identities = 78/214 (36%), Positives = 110/214 (51%), Gaps = 18/214 (8%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            VT    + L  ++    +L+EL L  N L    +  LC  L  P   L TL +  CG+TA
Sbjct: 211  VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
            + C DL   LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC  T+ CC
Sbjct: 271  KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971
               +SVL+ +  L EL +  N L+D GVR LC+GL  P          SV+      D  
Sbjct: 331  SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG---------SVLRVLWLADCD 381

Query: 972  EMSNSTSSLKRQRLGSERAASHVAQANLKLLDVS 1005
               +S SSL         AA+ +A  +L+ LD+S
Sbjct: 382  VSDSSCSSL---------AATLLANHSLRELDLS 406



 Score =  108 bits (270), Expect = 4e-23
 Identities = 61/148 (41%), Positives = 85/148 (57%), Gaps = 4/148 (2%)

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
           +++ LD+    LS +    L   L++     + +RL  CGLT   CKD++  LR N  L 
Sbjct: 4   DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
           EL+L  N L D G   + Q L+ PSCK+Q+L L +C LT   C  L+S L   P+L+EL 
Sbjct: 60  ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRL 956
           L  N L D G++LLCEGL  P C+L +L
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKL 147



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 49/124 (39%), Positives = 67/124 (54%)

Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
           SVL   R L EL +S N L  + V+ LC+ L +P  +L  L LA C ++   C  LA  L
Sbjct: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394

Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
            AN +L ELDLS N L DAG   L + +RQP C L++L L     + +    L ++    
Sbjct: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDK 454

Query: 922 PSLK 925
           PSL+
Sbjct: 455 PSLR 458



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)

Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
           P  V+   W+    V+D+    L + L    +L+ELDLS N L  + +  L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 838 LLETLRL 844
           LLE L L
Sbjct: 428 LLEQLVL 434


>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  130 bits (328), Expect = 7e-30
 Identities = 70/162 (43%), Positives = 100/162 (61%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A   +L S L+    L+EL LS N L  + ++ LC+ L  P+C LE L+L  C L+A
Sbjct: 97  LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C+ LA  LRA     EL +S N + +AG + LCQ L+   C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           +DL  ++++  SL+EL L  N L DVG+  LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258



 Score =  129 bits (323), Expect = 3e-29
 Identities = 77/199 (38%), Positives = 112/199 (56%), Gaps = 1/199 (0%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + + S L+V   L EL+L  N L    V  + + L+ P C ++ L L  C LT 
Sbjct: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C  L+  LR   TL EL LS N+L DAG + LC+ L  P C+L++LQL  C L++  C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDT 970
           + LASVL A P  KEL +  N++++ GVR+LC+GL+   C+L  L   S  +T     D 
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 971 GEMSNSTSSLKRQRLGSER 989
             +  S +SL+   LGS +
Sbjct: 220 CGIVASKASLRELALGSNK 238



 Score =  126 bits (316), Expect = 2e-28
 Identities = 67/154 (43%), Positives = 91/154 (59%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L SVL+   + KEL +S N ++ + V+ LC+ L+   C LE L+L  CG+T+++C+DL  
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            + +  +L EL L  N L D G   LC  L  PS +L+ L +  CG+T+  C DL  VL 
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           A  SLKEL L  N L D G RLLCE L  P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315



 Score =  121 bits (304), Expect = 4e-27
 Identities = 67/157 (42%), Positives = 87/157 (55%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L  VL+   +LKEL L+GN L     + LC+TL  P C LE+L +  C  TA  C   + 
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            L  N+ L EL +S N L DAG + LCQ L QP   L+ L L  C ++   C  LA+ L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
           A+ SL+ELDL  N L D G+  L E +R P C L +L
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQL 432



 Score =  119 bits (297), Expect = 3e-26
 Identities = 78/214 (36%), Positives = 110/214 (51%), Gaps = 18/214 (8%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            VT    + L  ++    +L+EL L  N L    +  LC  L  P   L TL +  CG+TA
Sbjct: 211  VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
            + C DL   LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC  T+ CC
Sbjct: 271  KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971
               +SVL+ +  L EL +  N L+D GVR LC+GL  P          SV+      D  
Sbjct: 331  SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG---------SVLRVLWLADCD 381

Query: 972  EMSNSTSSLKRQRLGSERAASHVAQANLKLLDVS 1005
               +S SSL         AA+ +A  +L+ LD+S
Sbjct: 382  VSDSSCSSL---------AATLLANHSLRELDLS 406



 Score =  108 bits (270), Expect = 4e-23
 Identities = 61/148 (41%), Positives = 85/148 (57%), Gaps = 4/148 (2%)

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
           +++ LD+    LS +    L   L++     + +RL  CGLT   CKD++  LR N  L 
Sbjct: 4   DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
           EL+L  N L D G   + Q L+ PSCK+Q+L L +C LT   C  L+S L   P+L+EL 
Sbjct: 60  ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRL 956
           L  N L D G++LLCEGL  P C+L +L
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKL 147



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 49/124 (39%), Positives = 67/124 (54%)

Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
           SVL   R L EL +S N L  + V+ LC+ L +P  +L  L LA C ++   C  LA  L
Sbjct: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394

Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
            AN +L ELDLS N L DAG   L + +RQP C L++L L     + +    L ++    
Sbjct: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDK 454

Query: 922 PSLK 925
           PSL+
Sbjct: 455 PSLR 458



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)

Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
           P  V+   W+    V+D+    L + L    +L+ELDLS N L  + +  L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 838 LLETLRL 844
           LLE L L
Sbjct: 428 LLEQLVL 434


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,204,486
Number of Sequences: 37866
Number of extensions: 2956969
Number of successful extensions: 10249
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 125
Number of HSP's that attempted gapping in prelim test: 9408
Number of HSP's gapped (non-prelim): 628
length of query: 1399
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1284
effective length of database: 13,892,928
effective search space: 17838519552
effective search space used: 17838519552
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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